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Sample records for schistosomiasis resource center

  1. The NIH-NIAID Schistosomiasis Resource Center at the Biomedical Research Institute: Molecular Redux

    PubMed Central

    Cody, James J.; Ittiprasert, Wannaporn; Miller, André N.; Henein, Lucie; Mentink-Kane, Margaret M.; Hsieh, Michael H.

    2016-01-01

    Schistosomiasis remains a health burden in many parts of the world. The complex life cycle of Schistosoma parasites and the economic and societal conditions present in endemic areas make the prospect of eradication unlikely in the foreseeable future. Continued and vigorous research efforts must therefore be directed at this disease, particularly since only a single World Health Organization (WHO)-approved drug is available for treatment. The National Institutes of Health (NIH)–National Institute of Allergy and Infectious Diseases (NIAID) Schistosomiasis Resource Center (SRC) at the Biomedical Research Institute provides investigators with the critical raw materials needed to carry out this important research. The SRC makes available, free of charge (including international shipping costs), not only infected host organisms but also a wide array of molecular reagents derived from all life stages of each of the three main human schistosome parasites. As the field of schistosomiasis research rapidly advances, it is likely to become increasingly reliant on omics, transgenics, epigenetics, and microbiome-related research approaches. The SRC has and will continue to monitor and contribute to advances in the field in order to support these research efforts with an expanding array of molecular reagents. In addition to providing investigators with source materials, the SRC has expanded its educational mission by offering a molecular techniques training course and has recently organized an international schistosomiasis-focused meeting. This review provides an overview of the materials and services that are available at the SRC for schistosomiasis researchers, with a focus on updates that have occurred since the original overview in 2008. PMID:27764112

  2. Schistosomiasis

    PubMed Central

    Tucker, Matthew S.; Karunaratne, Laksiri B.; Lewis, Fred A.; Freitas, Tori C.; Liang, Yung-san

    2014-01-01

    Schistosomiasis is the second most important parasitic disease in the world in terms of public health impact. Globally, it is estimated that the disease affects over 200 million people and is responsible for 200,000 deaths each year. The three major schistosomes infecting humans are Schistosoma mansoni, S. japonicum, and S. haematobium. Much immunological research has focused on schistosomiasis because of the pathological effects of the disease, which include liver fibrosis and bladder dysfunction. This Unit covers a wide range of aspects of maintaining the life cycles of these parasites, including preparation of schistosome egg antigen, maintenance of intermediate snail hosts, infection of the definitive and intermediate hosts, and others. The Unit primariiy focues on S. mansoni, but also includes coverage of S. japonicum and S. haematobium life cycles. PMID:18432750

  3. Language Resource Centers Program

    ERIC Educational Resources Information Center

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The Language Resource Centers (LRC) program provides grants to institutions of higher education to establish, strengthen, and operate resource centers that serve to improve the nation's capacity to teach and learn foreign languages. Eligible applicants are institutions of higher education. Duration of the grant is four years. Center activities…

  4. [Impact of water resource installations on the distribution of schistosomiasis and its intermediary hosts in Burkina Faso].

    PubMed

    Poda, Jean-Noël; Sondo, Blaise; Parent, Gérard

    2003-01-01

    Dams generally are a favourable biotope for the molluscs acting as intermediary hosts to schistosomiasis. The importance of the schistosomiasis endemic which follows depends on the interactions taking place between the parasites and their definitive (humans) and intermediary hosts. A preliminary sound knowledge of the prevailing epidemiological situations is therefore necessary to define an efficient programme to fight these infections. The extension of schistosomiasis following the installation of water resource facilities is significative of the part played by these hosts. In the hydroagricultural complex of Sourou, the prevalence of urinary schistosomiasis increased from 19% in 1954 to more than 70% in 1998-1999 in Guiédougou, the most ancient site. As to digestive schistosomiasis, almost unheard of until 1987, its prevalence ranged from 8% to 69% in 1998 in the villages located alongside the areas thus equipped. In the Kou Valley, the prevalence went up from 14% in 1957 to 80% in 1974 for urinary schistosomiasis and from 1.3% to 45% for intestinal schistosomiasis. The same tendencies are likely to appear in the hydraulic installations of Bagré, Ziga, and Kompienga. Dams thus constitute amplifying factors for the proliferation of species and for parasite-host interactions. All the actors (developers, populations and scientists) are faced with the challenge of finding a mean to control the development of schistosomiasis infections which are likely to seriously lessen the benefits expected from these hydraulic installations.

  5. Resource Centers; Some Ideas.

    ERIC Educational Resources Information Center

    Klitzke, Dwight Mark; Starkey, John

    Teachers, Principals, and other public school personnel interested in establishing learning resource centers are provided with guidelines and a framework within which they can structure their efforts. Professional literature, observation, and experimental trials serve as the sources from which observations are drawn. The advantages of the resource…

  6. Spatial patterns of schistosomiasis in Burkina Faso: relevance of human mobility and water resources development

    NASA Astrophysics Data System (ADS)

    Perez-Saez, Javier; Bertuzzo, Enrico; Frohelich, Jean-Marc; Mande, Theophile; Ceperley, Natalie; Sou, Mariam; Yacouba, Hamma; Maiga, Hamadou; Sokolow, Susanne; De Leo, Giulio; Casagrandi, Renato; Gatto, Marino; Mari, Lorenzo; Rinaldo, Andrea

    2015-04-01

    We study the spatial geography of schistosomiasis in the african context of Burkina Faso by means of a spatially explicit model of disease dynamics and spread. The relevance of our work lies in its ability to describe quantitatively a geographic stratification of the disease burden capable of reproducing important spatial differences, and drivers/controls of disease spread. Among the latters, we consider specifically the development and management of water resources which have been singled out empirically as an important risk factor for schistosomiasis. The model includes remotely acquired and objectively manipulated information on the distributions of population, infrastructure, elevation and climatic drivers. It also includes a general description of human mobility and addresses a first-order characterization of the ecology of the intermediate host of the parasite causing the disease based on maximum entropy learning of relevant environmenal covariates. Spatial patterns of the disease were analyzed about their disease-free equilibrium by proper extraction and mapping of suitable eigenvectors of the Jacobian matrix subsuming all stability properties of the system. Human mobility was found to be a primary control of both pathogen invasion success and of the overall distribution of disease burden. The effects of water resources development were studied by accounting for the (prior and posterior) average distances of human settlements from water bodies that may serve as suitable habitats to the intermediate host of the parasite. Water developments, in combination with human mobility, were quantitatively related to disease spread into regions previously nearly disease-free and to large-scale empirical incidence patterns. We concluded that while the model still needs refinements based on field and epidemiological evidence, the framework proposed provides a powerful tool for large-scale, long-term public health planning and management of schistosomiasis.

  7. The Web Resource Collaboration Center

    ERIC Educational Resources Information Center

    Dunlap, Joanna C.

    2004-01-01

    The Web Resource Collaboration Center (WRCC) is a web-based tool developed to help software engineers build their own web-based learning and performance support systems. Designed using various online communication and collaboration technologies, the WRCC enables people to: (1) build a learning and professional development resource that provides…

  8. Resource Centers for Gifted Education.

    ERIC Educational Resources Information Center

    Clark, Linda R.; And Others

    1995-01-01

    Shared Information Services is a state-operated network of four resource centers for gifted education in Indiana. The network provides support in the areas of program development, teacher education, classroom teaching resources, and program evaluation. A variety of library and technical assistance services is provided to teachers and others by…

  9. LEARNING AND INSTRUCTIONAL RESOURCES CENTER.

    ERIC Educational Resources Information Center

    THARP, CHARLES D.

    A DESCRIPTION OF THE INCEPTION, OBJECTIVES, OPERATION, EQUIPMENT, AND PERSONNEL OF THE LEARNING AND INSTRUCTIONAL RESOURCES CENTER OF THE UNIVERSITY OF MIAMI IS GIVEN. FACULTY COMMITTEES WERE APPOINTED AT THE UNIVERSITY OF MIAMI TO WORK OUT THE PHILOSOPHY OF A NEW DIVISION WITHIN THE UNIVERSITY WHICH WOULD MEET THE PROBLEMS OF THE INADEQUACY OF…

  10. Hepatobiliary Schistosomiasis

    PubMed Central

    Shaker, Yehia; Samy, Nervana; Ashour, Esmat

    2014-01-01

    Schistosomiasis is an ancient parasitic disease that has afflicted Egyptians since the time of the pharaohs. The disease is caused by lodged schistosome eggs in the host liver, evoking an immune response and leading in some patients to the development of hepatic granuloma and fibrosis. Here, we review the epidemiology, immunopathogenesis, and clinical profile of schistosomiasis. This information may aid in the development of more efficacious treatments and improved disease prognosis. PMID:26357627

  11. Hepatobiliary Schistosomiasis.

    PubMed

    Shaker, Yehia; Samy, Nervana; Ashour, Esmat

    2014-09-01

    Schistosomiasis is an ancient parasitic disease that has afflicted Egyptians since the time of the pharaohs. The disease is caused by lodged schistosome eggs in the host liver, evoking an immune response and leading in some patients to the development of hepatic granuloma and fibrosis. Here, we review the epidemiology, immunopathogenesis, and clinical profile of schistosomiasis. This information may aid in the development of more efficacious treatments and improved disease prognosis. PMID:26357627

  12. Pulmonary schistosomiasis.

    PubMed

    Hill, I R; Turk, E P

    1980-09-01

    Two cases are reported of the incidental finding of pulmonary schistosomiasis in the victims of a fatal aircraft accident. The presence of this disease had no bearing on the causation of the accident, but it gives insight into the potential hazards of dissemination of diseases by travellers. The finding also emphasises the value of routine postmortems and histology in all aircraft accident victims.

  13. MCLA-Berkshire Environmental Resource Center (BERC)

    SciTech Connect

    Monica Joslin

    2010-09-15

    The Berkshire Environmental Resource Center at the Massachusetts College of Liberal Arts was established in 2005 to advance student and faculty research, promote environmental awareness and preservation throughout the community, and serve as a resource center for students, faculty, and community members. The project proposed is to enhance programming and outreach.

  14. Long-term outcome after liver transplantation for hepatic schistosomiasis: a single-center experience over 15 years.

    PubMed

    El Moghazy, Walid; Kashkoush, Samy; O'hali, Wael; Abdallah, Khalid

    2015-01-01

    Our objective was to study the long-term outcomes of patients who had undergone liver transplantation because of schistosomiasis at our institute over the last 15 years. Four hundred forty-one patients underwent liver transplantation at our institute, and 14 did so for schistosomiasis. The survival of patients who underwent transplantation for schistosomiasis was compared with that of patients who underwent transplantation for other liver diseases. Survival curves were drawn via the Kaplan-Meier method and were compared with the log-rank test. P < 0.05 was considered significant. All 14 patients were male, and the average age was 56.8 ± 8.4 years. The average Model for End-Stage Liver Disease score was 18.2 ± 5.6, and the average Child-Pugh score was 10.6 ± 1.2. All patients had splenomegaly; pretransplant variceal bleeding occurred in 7 patients (50%), and portal vein thrombosis was diagnosed in 5 patients (36%). Patient survival was 75% 1 year after transplantation and 75% at the end of follow-up because no patients were lost after the first year. Patients who underwent transplantation for other causes achieved survival rates of 86% and 76% 1 and 10 years after transplantation, respectively. There was no significant survival difference between the 2 groups (P = 0.66). All patients who survived the early posttransplant period had functioning liver grafts with no reported diagnoses of schistosomiasis in the new grafts. In conclusion, liver transplantation for patients with schistosomiasis has a favorable outcome with no risk of reactivation.

  15. Efficacy of Myrrh in the treatment of schistosomiasis (haematobium and mansoni) in Ezbet El-Bakly, Tamyia Center, El-Fayoum Governorate, Egypt.

    PubMed

    Abo-Madyan, Ahmed A; Morsy, Tosson A; Motawea, Saad M

    2004-08-01

    Schistosomiasis remains a public health problem in Egypt, despite the continuous control effort. Most of the anti-schistosomal drugs have deleterious side effects or low efficacy. This necessitates a search for new safe and effective drug. A field survey was done in Ezbet El-Bakly (Tamyia Center) El-Fayoum Governorate to determine the magnitude of schistosomiasis haematobium and mansoni and to evaluate the efficacy of Mirazid (the oleo-resin extract from Myrrh of Commiphora molmol tree, family: Burseraceae) in the treatment of both types of schistosomiasis. Among the 1019 individuals parasitologically examined, the prevalence of S. haematobium and S. mansoni were 4.2% and 2.4% respectively and the geometric mean egg count (GMEC) were 33.2 eggs/10 ml urine and 113.3 eggs/gram stools. Most of the patients with haematobiasis and mansoniasis were <15 years (56.4% & 53.8%), males (56.4% & 53.8%) & illiterates (46.2% & 46.2%). All cases were treated by Myrrh (Mirazid) as two capsules (600 mg) on an empty stomach an hour before breakfast for six consecutive days and were followed up clinically and parasitologically by urine analysis by the sedimentation and nucleopore techniques and by hatching test and by stool analysis by sedimentation and Kato-Katz techniques and by hatching test. The parasitological cure rate after three months was 97.4% and 96.2% for S. haematobium and S. mansoni cases with the marvelous clinical cure without any side-effects. Patients not completely responded to a single course of treatment showed marked reduction of egg intensity. It is concluded that Mirazid proved to be safe and very effective in treatment of S. haematobium and S. mansoni infections under field conditions. PMID:15287168

  16. A model nursing computer resource center.

    PubMed

    Mueller, Sheryl S; Pullen, Richard L; McGee, K Sue

    2002-01-01

    Nursing graduates are required to demonstrate computer technology skills and critical reflective thinking skills in the workplace. The authors discuss a model computer resource center that enhances the acquisition of these requisite skills by students in both an associate degree and vocational nursing program. The computer resource center maximizes student learning and promotes faculty effectiveness and efficiency by a "full-service" approach to computerized testing, information technology instruction, online research, and interactive computer program practice. PMID:12023644

  17. A Model Learning Resource Center. Final Report.

    ERIC Educational Resources Information Center

    Crowley's Ridge Vocational Technical School, Forrest City, AR.

    Enrollees (aged 16-21) at Crowley's Ridge Vocational Technical School (Forrest City, Arkansas) had trouble mastering the vocational curriculum because they lacked academic skills in reading, mathematics, and language. Through research, it was determined that a Learning Resource Center could be the instructional tool that would remedy the academic…

  18. Museum Resources Center. Final Evaluation Report.

    ERIC Educational Resources Information Center

    Clinton County Board of Cooperative Educational Services, Ellenburg Depot, NY.

    This report describes and evaluates the Supplementary Educational Museum and Resource Center, ESEA Title III pilot project which began in 1967 and ended in 1971 for a four-county area. Major objectives of the program were to integrate field trips to museums and historic sites in social studies courses; to develop primary source materials; and to…

  19. The mouse resources at the RIKEN BioResource center.

    PubMed

    Yoshiki, Atsushi; Ike, Fumio; Mekada, Kazuyuki; Kitaura, Yasuyuki; Nakata, Hatsumi; Hiraiwa, Noriko; Mochida, Keiji; Ijuin, Maiko; Kadota, Masayo; Murakami, Ayumi; Ogura, Atsuo; Abe, Kuniya; Moriwaki, Kazuo; Obata, Yuichi

    2009-04-01

    Mice are one of the most important model organisms for studying biological phenomena and diseases processes in life sciences. The biomedical research community has succeeded in launching large scale strategic knockout mouse projects around the world. RIKEN BRC, a comprehensive government funded biological resource center was established in 2001. RIKEN BRC has been acting as the core facility for the mouse resources of the National BioResource Project (NBRP) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan since 2002. RIKEN BRC is a founding member of the Federation of International Mouse Resources (FIMRe) together with the Jackson Laboratory, the European Mouse Mutant Archive, and other centers, and has participated in the International Mouse Strain Resource (IMSR) to distribute mouse strains worldwide. With the support of the scientific community, RIKEN BRC has collected over 3,800 strains including inbred, transgenic, knockout, wild-derived, and ENU-induced mutant strains. Excellent mouse models for human diseases and gene functions from academic organizations and private companies are distributed through RIKEN BRC. To meet research and social needs, our mice will be rederived to a specific pathogen-free state, strictly monitored for their health, and accurately tested for their genetic modifications and backgrounds. Users can easily access our mouse resources through the internet and obtain the mouse strains for a minimal fee. Cryopreservation of embryos and sperm is used for efficient preservation of the increasing number of mouse resources. RIKEN BRC collaborates with FIMRe members to support Japanese scientists in the use of valuable mouse resources from around the world.

  20. Lewis Research Center earth resources program

    NASA Technical Reports Server (NTRS)

    Mark, H.

    1972-01-01

    The Lewis Research Center earth resources program efforts are in the areas of: (1) monitoring and rapid evaluation of water quality; (2) determining ice-type and ice coverage distribution to aid operations in a possible extension of the Great Lakes ice navigation and shipping season; (3) monitoring spread of crop viruses; and (4) extent of damage to strip mined areas as well as success of efforts to rehabilitate such areas for agriculture.

  1. A Theoretical Analysis of the Geography of Schistosomiasis in Burkina Faso Highlights the Roles of Human Mobility and Water Resources Development in Disease Transmission

    PubMed Central

    Perez-Saez, Javier; Mari, Lorenzo; Bertuzzo, Enrico; Casagrandi, Renato; Sokolow, Susanne H.; De Leo, Giulio A.; Mande, Theophile; Ceperley, Natalie; Froehlich, Jean-Marc; Sou, Mariam; Karambiri, Harouna; Yacouba, Hamma; Maiga, Amadou; Gatto, Marino; Rinaldo, Andrea

    2015-01-01

    We study the geography of schistosomiasis across Burkina Faso by means of a spatially explicit model of water-based disease dynamics. The model quantitatively addresses the geographic stratification of disease burden in a novel framework by explicitly accounting for drivers and controls of the disease, including spatial information on the distributions of population and infrastructure, jointly with a general description of human mobility and climatic/ecological drivers. Spatial patterns of disease are analysed by the extraction and the mapping of suitable eigenvectors of the Jacobian matrix subsuming the stability of the disease-free equilibrium. The relevance of the work lies in the novel mapping of disease burden, a byproduct of the parametrization induced by regional upscaling, by model-guided field validations and in the predictive scenarios allowed by exploiting the range of possible parameters and processes. Human mobility is found to be a primary control at regional scales both for pathogen invasion success and the overall distribution of disease burden. The effects of water resources development highlighted by systematic reviews are accounted for by the average distances of human settlements from water bodies that are habitats for the parasite’s intermediate host. Our results confirm the empirical findings about the role of water resources development on disease spread into regions previously nearly disease-free also by inspection of empirical prevalence patterns. We conclude that while the model still needs refinements based on field and epidemiological evidence, the proposed framework provides a powerful tool for large-scale public health planning and schistosomiasis management. PMID:26513655

  2. A Theoretical Analysis of the Geography of Schistosomiasis in Burkina Faso Highlights the Roles of Human Mobility and Water Resources Development in Disease Transmission.

    PubMed

    Perez-Saez, Javier; Mari, Lorenzo; Bertuzzo, Enrico; Casagrandi, Renato; Sokolow, Susanne H; De Leo, Giulio A; Mande, Theophile; Ceperley, Natalie; Froehlich, Jean-Marc; Sou, Mariam; Karambiri, Harouna; Yacouba, Hamma; Maiga, Amadou; Gatto, Marino; Rinaldo, Andrea

    2015-01-01

    We study the geography of schistosomiasis across Burkina Faso by means of a spatially explicit model of water-based disease dynamics. The model quantitatively addresses the geographic stratification of disease burden in a novel framework by explicitly accounting for drivers and controls of the disease, including spatial information on the distributions of population and infrastructure, jointly with a general description of human mobility and climatic/ecological drivers. Spatial patterns of disease are analysed by the extraction and the mapping of suitable eigenvectors of the Jacobian matrix subsuming the stability of the disease-free equilibrium. The relevance of the work lies in the novel mapping of disease burden, a byproduct of the parametrization induced by regional upscaling, by model-guided field validations and in the predictive scenarios allowed by exploiting the range of possible parameters and processes. Human mobility is found to be a primary control at regional scales both for pathogen invasion success and the overall distribution of disease burden. The effects of water resources development highlighted by systematic reviews are accounted for by the average distances of human settlements from water bodies that are habitats for the parasite's intermediate host. Our results confirm the empirical findings about the role of water resources development on disease spread into regions previously nearly disease-free also by inspection of empirical prevalence patterns. We conclude that while the model still needs refinements based on field and epidemiological evidence, the proposed framework provides a powerful tool for large-scale public health planning and schistosomiasis management.

  3. A Theoretical Analysis of the Geography of Schistosomiasis in Burkina Faso Highlights the Roles of Human Mobility and Water Resources Development in Disease Transmission.

    PubMed

    Perez-Saez, Javier; Mari, Lorenzo; Bertuzzo, Enrico; Casagrandi, Renato; Sokolow, Susanne H; De Leo, Giulio A; Mande, Theophile; Ceperley, Natalie; Froehlich, Jean-Marc; Sou, Mariam; Karambiri, Harouna; Yacouba, Hamma; Maiga, Amadou; Gatto, Marino; Rinaldo, Andrea

    2015-01-01

    We study the geography of schistosomiasis across Burkina Faso by means of a spatially explicit model of water-based disease dynamics. The model quantitatively addresses the geographic stratification of disease burden in a novel framework by explicitly accounting for drivers and controls of the disease, including spatial information on the distributions of population and infrastructure, jointly with a general description of human mobility and climatic/ecological drivers. Spatial patterns of disease are analysed by the extraction and the mapping of suitable eigenvectors of the Jacobian matrix subsuming the stability of the disease-free equilibrium. The relevance of the work lies in the novel mapping of disease burden, a byproduct of the parametrization induced by regional upscaling, by model-guided field validations and in the predictive scenarios allowed by exploiting the range of possible parameters and processes. Human mobility is found to be a primary control at regional scales both for pathogen invasion success and the overall distribution of disease burden. The effects of water resources development highlighted by systematic reviews are accounted for by the average distances of human settlements from water bodies that are habitats for the parasite's intermediate host. Our results confirm the empirical findings about the role of water resources development on disease spread into regions previously nearly disease-free also by inspection of empirical prevalence patterns. We conclude that while the model still needs refinements based on field and epidemiological evidence, the proposed framework provides a powerful tool for large-scale public health planning and schistosomiasis management. PMID:26513655

  4. United States Antarctic Resource Center (USARC)

    USGS Publications Warehouse

    ,

    2001-01-01

    The U.S. Antarctic Resource Center (USARC) is our Nation?s depository for Antarctic maps, charts, geodetic ground control, satellite images, aerial photographs, publications, slides, and video tapes. These resources are items produced by Antarctic Treaty nations in support of their activities in Antarctica and provided to the USARC in compliance with a standing resolution of the treaty providing for exchange of information. The U.S. Geological Survey (USGS) maintains these materials through an interagency cooperative agreement with the National Science Foundation (NSF), which also supports the USGS Antarctic Mapping Program. The USARC develops and maintains the Antarctic Web site (usarc.usgs.gov) and its supporting data bases, as well as providing access to other online digital data bases, such as the Atlas of Antarctic Resources.

  5. NASA Johnson Space Center Biomedical Research Resources

    NASA Technical Reports Server (NTRS)

    Paloski, W. H.

    1999-01-01

    Johnson Space Center (JSC) medical sciences laboratories constitute a national resource for support of medical operations and life sciences research enabling a human presence in space. They play a critical role in evaluating, defining, and mitigation the untoward effect of human adaption to space flight. Over the years they have developed the unique facilities and expertise required to perform: biomedical sample analysis and physiological performance tests supporting medical evaluations of space flight crew members and scientific investigations of the operationally relevant medical, physiological, cellular, and biochemical issues associated with human space flight. A general overview of these laboratories is presented in viewgraph form.

  6. Marshall Space Flight Center Telescience Resource Kit

    NASA Technical Reports Server (NTRS)

    Wade, Gina

    2016-01-01

    Telescience Resource Kit (TReK) is a suite of software applications that can be used to monitor and control assets in space or on the ground. The Telescience Resource Kit was originally developed for the International Space Station program. Since then it has been used to support a variety of NASA programs and projects including the WB-57 Ascent Vehicle Experiment (WAVE) project, the Fast Affordable Science and Technology Satellite (FASTSAT) project, and the Constellation Program. The Payloads Operations Center (POC), also known as the Payload Operations Integration Center (POIC), provides the capability for payload users to operate their payloads at their home sites. In this environment, TReK provides local ground support system services and an interface to utilize remote services provided by the POC. TReK provides ground system services for local and remote payload user sites including International Partner sites, Telescience Support Centers, and U.S. Investigator sites in over 40 locations worldwide. General Capabilities: Support for various data interfaces such as User Datagram Protocol, Transmission Control Protocol, and Serial interfaces. Data Services - retrieve, process, record, playback, forward, and display data (ground based data or telemetry data). Command - create, modify, send, and track commands. Command Management - Configure one TReK system to serve as a command server/filter for other TReK systems. Database - databases are used to store telemetry and command definition information. Application Programming Interface (API) - ANSI C interface compatible with commercial products such as Visual C++, Visual Basic, LabVIEW, Borland C++, etc. The TReK API provides a bridge for users to develop software to access and extend TReK services. Environments - development, test, simulations, training, and flight. Includes standalone training simulators.

  7. A Resource Center for Informal Science Education

    NASA Astrophysics Data System (ADS)

    Dickow, B.

    2011-12-01

    Informal science education (ISE) is playing an increasingly important role in how and where the public engages with science. A growing body of research is showing that people learn the majority of their science knowledge outside of school (Falk & Dierking, 2010). The ISE field includes a wide variety of sources, including the internet, TV programs, magazines, hobby clubs and museums, all sectors of the informal science education field. These experiences touch large numbers of people throughout their lifetimes. If you would like to share your research with the public, ISE can be an effective conduit for meaningful science communication. However, because the ISE field is so diverse, it can be overwhelming with its multiple entry points. If you already are part of an ISE initiative, knowing how to access the most useful resources easily can also be daunting. CAISE, the Center for Advancement of Informal Science Education, is a resource center for the ISE field funded by the National Science Foundation (NSF). CAISE can help connect you to the knowledge and people of ISE, through its website, products and in-person convenings. The proposed CAISE presentation will outline the diversity of the field and concisely present data that will make the case for the impact of ISE. We will focus on examples of successful programs that connect science with the public and that bring together AGU's science research community with practitioners and researchers within ISE. Pathways to various ISE resources in the form of current CAISE initiatives will be described as well. The presentation will include an interview section in which a CAISE staff member will ask questions of a scientist involved in an ISE initiative in order to detail one example of how ISE can be a valuable tool for engaging the public in science. Time for audience Q&A also will be included in the session.

  8. Community Involvement: A Case Study of the Education Resource Center.

    ERIC Educational Resources Information Center

    Wilson, Stephen; And Others

    The Education Resource Center (ERC) is a community-based teachers' resource center located in Chicago (Illinois). Its conceptual base is broader than that of a typical teachers center as ERC represents a community-based social movement with a wider orientation than teacher training. ERC's policy board reflects community organizations and the…

  9. Survey of Staff Perceptions of the AEL Resource Center.

    ERIC Educational Resources Information Center

    Cowley, Kimberly S.

    The Resource Center at the Appalachia Educational Laboratory (AEL), Inc., provides direct services to clients both within and outside AEL, as well as serving as a repository and distribution center for educational materials. Three main objectives were identified: to discover the extent to which staff use current components of the Resource Center;…

  10. Virtual Resources Centers and Their Role in Small Rural Schools.

    ERIC Educational Resources Information Center

    Freitas, Candido Varela de; Silva, Antonio Pedro da

    Virtual resources centers have been considered a pedagogical tool since the increasing development of electronic means allowed for the storage of huge amounts of information and its easy retrieval. Bearing in mind the need for enhancing the appearance of those centers, a discipline of "Management of Resources Centers" was included in a specialized…

  11. National Newborn Screening and Genetics Resource Center

    MedlinePlus

    ... GENERAL INFORMATION Conditions Screened by US Programs General Resources Genetics Birth Defects Hearing Screening FOR PROFESSIONALS ACT Sheets(ACMG) General Resources Newborn Screening Genetics Birth Defects FOR FAMILIES FAQs ...

  12. Adult Resource Center--A Community/University Project.

    ERIC Educational Resources Information Center

    Vegso, Kathryn A.

    Cooperative planning, based upon a decade of reentry programs for adults, culminated in the establishment of a public service known as the Adult Resource Center at the University of Akron (Ohio). Located in a renovated building between the campus and the downtown community, the Adult Resource Center serves as a liaison with social service…

  13. The Bilingual Resource Center; School Year 1974-1975.

    ERIC Educational Resources Information Center

    Mortensen, Erik

    This report presents a description and evaluation of the Bilingual Resource Center (BRC) funded under Title III of the Elementary and Secondary Education Act of 1965. This center functioned mainly as a clearinghouse, resource library, and dissemination unit on bilingual/bicultural education. The program's primary objectives were related to goals…

  14. CRC Career Resource Centers. Where Students Focus on the Future.

    ERIC Educational Resources Information Center

    Hubek, June; Zucca, Ida

    This handbook for educators is designed as a guide to planning, implementing, and evaluating a career resource center adaptable to all levels of education. It is divided into five sections. Section 1 discussed the major services of a career resource center and the benefits derived from these services. A step-by-step procedure on how to establish a…

  15. Educator Resource Center for NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Bridgford, Todd; Koltun, Nick R.

    2003-01-01

    The goal of the ERCN is to provide expertise and facilities to help educators access and utilize science, mathematics, and technology instructional products aligned with national standards and appropriate state frameworks and based on NASA s unique mission and results. The NASA Langley s Office of Education has established the service area for this ERC to be the five states of Kentucky, North Carolina, South Carolina, Virginia and West Virginia. This educational grant activity is associated with NASA s Mission to inspire the next generation of explorers.. .as only NASA can. The communication of NASA s knowledge is the prime role of this ERC. Functioning as a dissemination system of instructional materials and support for pre-college education programs we have met the NASA Education ERCN Program's goal. The following ERCN objectives have been accomplished: Demonstrate and facilitate the use of NASA educational products and technologies in print, video and web based formats. Examples include but are not limited to NASA approved Educator s Guides with Activities based on national standards for appropriate subjects and grade levels. We have demonstrated the use videotape series in analogue format and the new digital video instructional systems along with the use of NASA TV. The promotion of web page based resources such as the new NASA Portal web and the ability to download print resources is continuously facilitated in workshops. This objective has been completed by educator contacts that include on-site visits, phone requests, postal mail requests, e-mail requests, fax requests and workshops offered.

  16. Engaging with Schools: National Family Resource Centers

    ERIC Educational Resources Information Center

    Dewey, Eric; Mitchell, Erica

    2014-01-01

    More than one in four children in Tennessee live in poverty, and in Nashville the number creeps higher to one in three (Kids Count Data Center, 2012). Nearly three out of every four children in Metro Nashville Public Schools qualify for free and reduced lunch and are considered at risk (Tennessee Department of Education, 2013). This concentration…

  17. NASA Center for Computational Sciences: History and Resources

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The Nasa Center for Computational Sciences (NCCS) has been a leading capacity computing facility, providing a production environment and support resources to address the challenges facing the Earth and space sciences research community.

  18. The National Lending Library: Information Resource Center Extraordinaire

    ERIC Educational Resources Information Center

    Peck, Theodore P.

    1973-01-01

    This article provides a brief glimpse of the National Lending Library at Boston Spa in Yorkshire which is the primary bibliographic resource center for science and technology in Great Britain. (Author)

  19. Surgical pathology of schistosomiasis.

    PubMed Central

    Mohammed, Aminu Z.; Edino, Steven T.; Samaila, Adamu A.

    2007-01-01

    Schistosomiasis remains an important health problem in many tropical countries and is being seen with increasing frequency in immigrant populations and tourists in developed countries. The pattern of organ involvement and clinical presentation of schistosomiasis in 80 patients (male: female, 9:1) during a five-year period (2001-2005) was examined from archival histopathology records. The urinary bladder was the most common organ affected [50 (62.5%)]. Gastrointestinal, male and female genital schistosomiasis were detected in 12 (15%), eight (10%) and five (6.1%) cases, respectively. Hematuria was the most common presenting symptom [34 (42.5%)], and bladder cancer was the only malignancy found to be associated with the infection. A high clinical index of suspicion usually allows for a preoperative diagnosis where indicated and avoidance of radical surgery. While research for the development of an effective vaccine continues, a plea is made for the expansion of multinational control programs in sub-Saharan Africa. PMID:17534016

  20. Natural Resources at Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Phillips, Lynne

    2015-01-01

    Informative presentation on the purpose and need for an Ecological Program at the Kennedy Space Center. Includes the federal laws mandating the program followed by a description of many of the long term monitoring projects. Projects include wildlife surveying by observation as well as interactive surveys to collect basic animal data for analysis of trends in habitat use and ecosystem health. The program is designed for a broad range in audience from elementary to college level.

  1. Schistosomiasis control in China.

    PubMed

    Yuan, H C

    1995-01-01

    After three decades' efforts, schistosomiasis japonica were controlled in one-third (4/12) of endemic provinces and 68.2% (259/380) of endemic counties throughout the country. The remaining 121 endemic counties are located primarily in the lake and mountainous regions. The epidemiological and ecological features of the lake and mountainous areas are different from the other endemic areas. The major schistosomiasis control efforts in China can be characterized as follows: (1) Application of centralized leadership and management, since schistosomiasis control is a task not only of the Ministry of Public Health, but also of all local governments in the endemic areas; (2) Integration of actions taken by various departments or bureaus, such as agriculture, water conservation and public health; (3) Promotion of mass participation; (4) Organization of strong professional teams; (5) Raising sufficient funds. Strategies on schistosomiasis control applied in different areas are divided into three levels: (1) In the areas where the schistosomiasis has been successfully controlled, surveillance must be maintained and immediate action should be taken where new infections occur and/or vector snails are found, so that control can be reestablished quickly; (2) In the areas where schistosomiasis has been partially controlled, any residents and/or live-stock infected should be examined and treated promptly with due care, and environment modifying and/or mollusciding must be used to eliminate the remaining snails; (3) In the areas where transmission has not been controlled, the main strategy is to control morbidity.(ABSTRACT TRUNCATED AT 250 WORDS)

  2. National Regional Resource Center of Pennsylvania. Final Technical Report.

    ERIC Educational Resources Information Center

    Streissguth, William O.; Goode, Paul

    The final report covers activities of the National Regional Resource Center in the area of special education from 1970 through June 30, 1974. Reported is program emphasis on the development of a statewide diagnostic-prescriptive resource system including target classes (which served as data collection points and demonstration classes),…

  3. 76 FR 53885 - Patent and Trademark Resource Centers Metrics

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... United States Patent and Trademark Office Patent and Trademark Resource Centers Metrics ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office (USPTO), as part of its... following methods: E-mail: InformationCollection@uspto.gov . Include ``Patent and Trademark Resource...

  4. Instructional Technology and Learning Resource Center-Based Community Education.

    ERIC Educational Resources Information Center

    Brown, James W.

    A survey of nonformal community education activities was conducted to determine specific use of media for identified educational and informational purposes. The results presented in this report are intended to provide resource information to professionals and paraprofessionals who ultimately may be employed in Learning Resource Center-Based…

  5. Citrus conservation at the National Center for Genetic Resources Preservation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The USDA-ARS National Center for Genetic Resources Preservation maintains the base collection of genetic resources for the National Plant Germplasm System, a network of federal plant collections focused on conserving crops key to American agriculture. NCGRP research scientists have found ways to con...

  6. IYA Resources From The Harvard Smithsonian Center For Astrophysics

    NASA Astrophysics Data System (ADS)

    Reinfeld, Erika L.; Dussault, M. E.; Gould, R. R.; Steel, S. J.; Schneps, M. H.; Grainger, C. A.; Griswold, A.

    2008-05-01

    From museum exhibitions to professional development videos, the Science Education Department at the Harvard-Smithsonian Center for Astrophysics (CfA) has a long tradition of producing high quality education resources for students, teachers, and the public. This poster highlights new resources available to astronomers of all ages and backgrounds during the International Year of Astronomy. The MicroObservatory online telescope center will allow anyone with an email address to recapture the observations of Galileo on their own personal computers. The Beyond the Solar System professional development project follows in the footsteps of "A Private Universe" and "Minds of Our Own," providing new resources developed with the latest in scientific and educational research. And, in 2009, we will open a new traveling museum exhibition about black holes, featuring innovative new technologies, visualizations, and components designed with input from youth centers across the country. Learn more about these projects as the CfA continues to open the universe to new observers.

  7. [Schistosomiasis and acute appendicitis].

    PubMed

    Figueiredo, Jacinta; Santos, Ângela; Clemente, Horácio; Lourenço, Augusto; Costa, Sandra; Grácio, Maria Amélia; Belo, Silvana

    2014-01-01

    Acute appendicitis associated to Schistosoma haematobium and S. mansoni infection has been found in patients submitted to urgent appendectomy at the Hospital Américo Boavida in Luanda. Due to the high prevalence and morbidity caused by schistosomiasis (or bilharziasis) in the country, we suspect that the involvement of Schistosoma infection on appendicular pathology could be very frequent, in particular for those individuals more exposed to the parasite transmission. We report two clinical cases of acute appendicitis whose surgical specimens of the appendix revealed S. haematobium and S. mansoni eggs in histological samples. The reported patients live in endemic areas and have been exposed to schistosome during childhood, which may explain the infection's chronicity. Information of these clinical cases could be relevant, particularly for surgery specialists and clinical pathologists, due to the possibility of finding more patients with concurrent appendicitis and schistosomiasis.

  8. Immunology of schistosomiasis*

    PubMed Central

    1974-01-01

    This Memorandum, after summarizing the life cycle of the different species of human schistosome, reviews the present knowledge of the immunology of schistosomiasis. Each stage of the parasite contains antigen that may stimulate an immune response. However, at the moment there are no accepted serological in vitro tests that correlate with protection; this develops only after the host has experienced a living infection, which suggests that the stimulation of immunity is due to some metabolic process involving the release of protective antigen. The adult worm, however, seems to be able to escape the immune mechanism of the host. Specific antigens are also released by the eggs, and the immune response against these antigens seems to cause granuloma formation around the egg itself. The granuloma is the main lesion found in schistosomiasis. Evidence for protective immunity in experimental animals and man is reviewed, together with the possible mechanism by which the adult worm escapes the immune response of the host. A review of methods used for the diagnosis of schistosomiasis and a list of recommendations for further research are also included. PMID:4219757

  9. The Youth Resource Center--A Systems Approach.

    ERIC Educational Resources Information Center

    Aron, Robert D.; Gullotta, Thomas P.

    This paper describes the Youth Resource Center (YRC) of Glastonbury, Connecticut--a multifaceted treatment facility. The YRC is based on a Systems-Interaction (SI) model of service, which maintains that a system can be changed by intervention at any point in the system; consequently, the same goals can be achieved through various target groups or…

  10. Building an Information Resource Center for Competitive Intelligence.

    ERIC Educational Resources Information Center

    Martin, J. Sperling

    1992-01-01

    Outlines considerations in the design of a Competitive Intelligence Information Resource Center (CIIRC), which is needed by business organizations for effective strategic decision making. Discussed are user needs, user participation, information sources, technology and interface design, operational characteristics, and planning for implementation.…

  11. Electronic Commerce Resource Centers. An Industry--University Partnership.

    ERIC Educational Resources Information Center

    Gulledge, Thomas R.; Sommer, Rainer; Tarimcilar, M. Murat

    1999-01-01

    Electronic Commerce Resource Centers focus on transferring emerging technologies to small businesses through university/industry partnerships. Successful implementation hinges on a strategic operating plan, creation of measurable value for customers, investment in customer-targeted training, and measurement of performance outputs. (SK)

  12. Community Engagement and the Resource Centers for Minority Aging Research

    ERIC Educational Resources Information Center

    Sood, Johanna R.; Stahl, Sidney M.

    2011-01-01

    The National Institute on Aging created the Resource Centers for Minority Aging Research (RCMARs) to address infrastructure development intended to reduce health disparities among older adults. The overall goals of the RCMARs are to (a) increase the size of the cadre of researchers conducting research on issues related to minority aging; (b)…

  13. Incountry Resource Center Workshop. A Training Manual. No. T-48.

    ERIC Educational Resources Information Center

    PADCO, Inc., Washington, DC.

    Incountry Resource Centers (IRC) are vehicles for sharing technical information among persons working to further development goals, and the workshop described in this trainer's manual is designed to help local Peace Corps staff and/or volunteers to establish, expand, or improve an IRC appropriate to the needs and conditions of their country.…

  14. Resource Centers and Carrel Design: An Instructional Module.

    ERIC Educational Resources Information Center

    Wiley, Ann L.

    Basic considerations in the design of carrels and resource centers are covered in learner objectives, text, practice exercises, and answer sheets in this learning module. Topics addressed include factors influencing carrel design, workspace dimensions for writing carrels and electrically wired carrels, the proper distance from the chair seat to…

  15. Collection Development Policies for the RWC Learning Resources Center.

    ERIC Educational Resources Information Center

    Wilson, Lucy, Comp.

    This manual begins by providing background on the program, collection, and acquisition processes of the Raymond Walters College (RWC) Learning Resources Center. The next section describes collection development policies for: (1) the academic departments (Animal Health; Behavioral Sciences; Biology; Business and Economics; Chemistry; Dental…

  16. Multi-Cultural Resource Center Materials Handbook, Grades K-3.

    ERIC Educational Resources Information Center

    Gillespie, Mary F.; Barrientos, Anita

    This annotated bibliography cites multicultural materials whose themes correlate with basic concepts taught in the primary grades. The items are in the Multi-Cultural Resource Center of the Toledo, Ohio public schools. The purpose of the bibliography is to help teachers integrate materials into their classroom. Films, filmstrips, books, study…

  17. Community knowledge, attitudes and practices on schistosomiasis in western Kenya--the SCORE Project.

    PubMed

    Musuva, Rosemary M; Awiti, Alphonce; Omedo, Martin; Ogutu, Michael; Secor, W Evan; Montgomery, Susan P; Alaii, Jane; Mwinzi, Pauline N M

    2014-04-01

    In an effort to improve intervention strategies, community knowledge, attitudes, and practices on schistosomiasis were evaluated using focus group discussions involving 237 participants, in eight Schistosoma mansoni high prevalence districts in rural Nyanza Province, Kenya. The majority of participants reported having heard about schistosomiasis through schools, posters, radio announcements, and community gatherings. Participants had a variety of beliefs about contracting schistosomiasis, including associating it with dirty drinking water and uncooked or contaminated food. Avenues for seeking treatment included health centers, spiritual intervention, herbal treatments, and medicine shops, with health centers receiving the most mention. Barriers to schistosomiasis control included attitudes of community members toward the infection, especially misconceptions that lead to stigma and the perception that diagnosis and treatment are expensive. Schools were the most common avenue for receiving information, suggesting that the existing education infrastructure can be used for health education and improved sensitization about schistosomiasis control programs. PMID:24534810

  18. 34 CFR 669.1 - What is the Language Resource Centers Program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What is the Language Resource Centers Program? 669.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION LANGUAGE RESOURCE CENTERS PROGRAM General § 669.1 What is the Language Resource Centers Program? The Language Resource Centers Program makes awards, through grants...

  19. 34 CFR 669.1 - What is the Language Resource Centers Program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What is the Language Resource Centers Program? 669.1... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION LANGUAGE RESOURCE CENTERS PROGRAM General § 669.1 What is the Language Resource Centers Program? The Language Resource Centers Program makes awards, through grants...

  20. The NIH-NIAID Filariasis Research Reagent Resource Center

    PubMed Central

    Michalski, Michelle L.; Griffiths, Kathryn G.; Williams, Steven A.; Kaplan, Ray M.; Moorhead, Andrew R.

    2011-01-01

    Filarial worms cause a variety of tropical diseases in humans; however, they are difficult to study because they have complex life cycles that require arthropod intermediate hosts and mammalian definitive hosts. Research efforts in industrialized countries are further complicated by the fact that some filarial nematodes that cause disease in humans are restricted in host specificity to humans alone. This potentially makes the commitment to research difficult, expensive, and restrictive. Over 40 years ago, the United States National Institutes of Health–National Institute of Allergy and Infectious Diseases (NIH-NIAID) established a resource from which investigators could obtain various filarial parasite species and life cycle stages without having to expend the effort and funds necessary to maintain the entire life cycles in their own laboratories. This centralized resource (The Filariasis Research Reagent Resource Center, or FR3) translated into cost savings to both NIH-NIAID and to principal investigators by freeing up personnel costs on grants and allowing investigators to divert more funds to targeted research goals. Many investigators, especially those new to the field of tropical medicine, are unaware of the scope of materials and support provided by the FR3. This review is intended to provide a short history of the contract, brief descriptions of the fiilarial species and molecular resources provided, and an estimate of the impact the resource has had on the research community, and describes some new additions and potential benefits the resource center might have for the ever-changing research interests of investigators. PMID:22140585

  1. Annotated Resource List of Peace Education Resources Available from Wilmington College Peace Resource Center, Hiroshima/Nagasaki Memorial Collection.

    ERIC Educational Resources Information Center

    Wilmington Coll., OH. Peace Resource Center.

    Over 130 print and nonprint peace education resources for use with adult groups and elementary, secondary, and college students are described. Audiovisuals may be rented and books may be purchased from the Wilmington College (Ohio) Peace Resource Center. Audiovisuals, including slides, videotapes and videotape cassettes, and 16mm films, are…

  2. Amarillo National Resource Center for Plutonium 1999 plan

    SciTech Connect

    1999-01-30

    The purpose of the Amarillo National Resource Center for Plutonium is to serve the Texas Panhandle, the State of Texas and the US Department of Energy by: conducting scientific and technical research; advising decision makers; and providing information on nuclear weapons materials and related environment, safety, health, and nonproliferation issues while building academic excellence in science and technology. This paper describes the electronic resource library which provides the national archives of technical, policy, historical, and educational information on plutonium. Research projects related to the following topics are described: Environmental restoration and protection; Safety and health; Waste management; Education; Training; Instrumentation development; Materials science; Plutonium processing and handling; and Storage.

  3. Ultrasound assessment of schistosomiasis.

    PubMed

    Richter, J; Botelho, M C; Holtfreter, M C; Akpata, R; El Scheich, T; Neumayr, A; Brunetti, E; Hatz, C; Dong, Y; Dietrich, C F

    2016-07-01

    In 2000, the World Health Organization (WHO) issued an ultrasound field protocol for assessing the morbidity due to Schistosoma (S.) haematobium and S. mansoni. The experience with this classification has recently been reviewed systematically. The WHO protocol was well accepted worldwide. Here we review the use of ultrasound to assess the morbidity due to schistosomiasis with emphasis on easy, quick, and reproducible ways that can be used in the field. Findings obtained with high-end ultrasound scanners in the hospital setting that might eventually have applications in the field are also described. PMID:27429103

  4. Editors and author resource centers actively used by attendees

    NASA Astrophysics Data System (ADS)

    Major, Barbara

    2012-02-01

    At the 2011 Fall Meeting, as in previous years, the Editors Resource Center located on the second floor of Moscone West was buzzing with activity: editors talking with other editors, collaborating with associate editors, speaking with authors, and meeting with students. In addition, several editors took part in "Meet the Editor" informal sessions, a new feature introduced for the 2011 meeting to strengthen the partnership between authors and editors. The map "Where are you from?" (see photo), outside the Editors Resource Center, drew the attention of many attendees who were eager to place their colored dots on the map. The Author Resource Center, located in the AGU Marketplace, became a hub for AGU veteran authors and potential authors alike. Staff were there to answer both editorial and technical questions, especially the most frequent one: What happens after my paper is accepted? The running slideshow that described all aspects of the AGU publications program sparked a myriad of questions, which AGU staff were happy to answer.

  5. Strategies for developing biostatistics resources in an academic health center.

    PubMed

    Welty, Leah J; Carter, Rickey E; Finkelstein, Dianne M; Harrell, Frank E; Lindsell, Christopher J; Macaluso, Maurizio; Mazumdar, Madhu; Nietert, Paul J; Oster, Robert A; Pollock, Brad H; Roberson, Paula K; Ware, James H

    2013-04-01

    Biostatistics--the application of statistics to understanding health and biology-provides powerful tools for developing research questions, designing studies, refining measurements, analyzing data, and interpreting findings. Biostatistics plays an important role in health-related research, yet biostatistics resources are often fragmented, ad hoc, or oversubscribed within academic health centers (AHCs). Given the increasing complexity and quantity of health-related data, the emphasis on accelerating clinical and translational science, and the importance of conducting reproducible research, the need for the thoughtful development of biostatistics resources within AHCs is growing.In this article, the authors identify strategies for developing biostatistics resources in three areas: (1) recruiting and retaining biostatisticians, (2) efficiently using biostatistics resources, and (3) improving biostatistical contributions to science. AHCs should consider these three domains in building strong biostatistics resources, which they can leverage to support a broad spectrum of research. For each of the three domains, the authors describe the advantages and disadvantages of AHCs creating centralized biostatistics units rather than dispersing such resources across clinical departments or other research units. They also address the challenges that biostatisticians face in contributing to research without sacrificing their individual professional growth or the trajectory of their research teams. The authors ultimately recommend that AHCs create centralized biostatistics units because this approach offers distinct advantages both to investigators who collaborate with biostatisticians as well as to the biostatisticians themselves, and it is better suited to accomplish the research and education missions of AHCs.

  6. 34 CFR 464.1 - What is the State Literacy Resource Centers Program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM General § 464.1 What is the State Literacy Resource Centers Program? The State Literacy Resource...

  7. 34 CFR 464.1 - What is the State Literacy Resource Centers Program?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM General § 464.1 What is the State Literacy Resource Centers Program? The State Literacy Resource...

  8. 34 CFR 464.1 - What is the State Literacy Resource Centers Program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM General § 464.1 What is the State Literacy Resource Centers Program? The State Literacy Resource...

  9. 34 CFR 464.1 - What is the State Literacy Resource Centers Program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM General § 464.1 What is the State Literacy Resource Centers Program? The State Literacy Resource...

  10. 34 CFR 464.1 - What is the State Literacy Resource Centers Program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false What is the State Literacy Resource Centers Program...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM General § 464.1 What is the State Literacy Resource Centers Program? The State Literacy Resource...

  11. NASA Langley Teacher Resource Center at the Virginia Air and Space Center

    NASA Technical Reports Server (NTRS)

    Maher, Kim L.

    1999-01-01

    Nation's education goals through expanding and enhancing the scientific an technological competence of students and educators. To help disseminate NASA instructional materials and educational information, NASA's Education Division has established the Educator Resource Center Network. Through this network (ERCN), educators are provided the opportunity to receive free instructional information, materials, consultation, and training workshops on NASA educational products. The Office of Education at NASA Langley Research Center offers an extension of its Precollege Education program by supporting the NASA LARC Educator Resource Center at the Virginia Air & Space Center, the official visitor center for NASA LARC. This facility is the principal distribution point for educators in the five state service region that includes Virginia, West Virginia, Kentucky, North Carolina and South Carolina. The primary goal, to provide expertise and facilities to help educators access and utilize science, mathematics, and technology instructional products aligned with national standards and appropriate state frameworks and based on NASA's unique mission and results, has been accomplished. This ERC had 15,200 contacts and disseminated over 190,000 instructional items during the period of performance. In addition the manager attended 35 conferences, workshops, and educational meetings as an GR, presenter, or participant. The objective to demonstrate and facilitate the use of educational technologies has been accomplished through the following: The ERC's web page has been developed as a cyber-gateway to a multitude of NASA and other educational resources as well as to Our own database of current resource materials. NASA CORE CD-ROM technology is regularly demonstrated and promoted using the center's computers. NASA TV is available, demonstrated to educators, and used to facilitate the downlinking of NASA educational programming.

  12. Immunology of human schistosomiasis

    PubMed Central

    Colley, D G; Secor, W E

    2014-01-01

    There is a wealth of immunologic studies that have been carried out in experimental and human schistosomiasis that can be classified into three main areas: immunopathogenesis, resistance to reinfection and diagnostics. It is clear that the bulk of, if not all, morbidity due to human schistosomiasis results from immune-response-based inflammation against eggs lodged in the body, either as regulated chronic inflammation or resulting in fibrotic lesions. However, the exact nature of these responses, the antigens to which they are mounted and the mechanisms of the critical regulatory responses are still being sorted out. It is also becoming apparent that protective immunity against schistosomula as they develop into adult worms develops slowly and is hastened by the dying of adult worms, either naturally or when they are killed by praziquantel. However, as with anti-egg responses, the responsible immune mechanisms and inducing antigens are not clearly established, nor are any potential regulatory responses known. Finally, a wide variety of immune markers, both cellular and humoral, can be used to demonstrate exposure to schistosomes, and immunologic measurement of schistosome antigens can be used to detect, and thus diagnose, active infections. All three areas contribute to the public health response to human schistosome infections. PMID:25142505

  13. Biosecurity and Health Monitoring at the Zebrafish International Resource Center.

    PubMed

    Murray, Katrina N; Varga, Zoltán M; Kent, Michael L

    2016-07-01

    The Zebrafish International Resource Center (ZIRC) is a repository and distribution center for mutant, transgenic, and wild-type zebrafish. In recent years annual imports of new zebrafish lines to ZIRC have increased tremendously. In addition, after 15 years of research, we have identified some of the most virulent pathogens affecting zebrafish that should be avoided in large production facilities, such as ZIRC. Therefore, while importing a high volume of new lines we prioritize safeguarding the health of our in-house fish colony. Here, we describe the biosecurity and health-monitoring program implemented at ZIRC. This strategy was designed to prevent introduction of new zebrafish pathogens, minimize pathogens already present in the facility, and ensure a healthy zebrafish colony for in-house uses and shipment to customers.

  14. Maintenance of Zebrafish Lines at the European Zebrafish Resource Center

    PubMed Central

    Borel, Nadine; Ferg, Marco; Maier, Jana Viktoria; Strähle, Uwe

    2016-01-01

    Abstract We have established a European Zebrafish Resource Center (EZRC) at the KIT. This center not only maintains and distributes a large number of existing mutant and transgenic zebrafish lines but also gives zebrafish researchers access to screening services and technologies such as imaging and high-throughput sequencing, provided by the Institute of Toxicology and Genetics (ITG). The EZRC maintains and distributes the stock collection of the Nüsslein-Volhard laboratory, comprising over 2000 publicly released mutations, as frozen sperm samples. Within the framework of the ZF-HEALTH EU project, the EZRC distributes over 10,000 knockout mutations from the Sanger Institute (United Kingdom), as well as over 100 mutant and transgenic lines from other sources. In this article, we detail the measures we have taken to ensure the health of our fish, including hygiene, quarantine, and veterinary inspections. PMID:27351617

  15. New diagnostic tools in schistosomiasis.

    PubMed

    Utzinger, J; Becker, S L; van Lieshout, L; van Dam, G J; Knopp, S

    2015-06-01

    Schistosomiasis is a water-based parasitic disease that affects over 250 million people. Control efforts have long been in vain, which is one reason why schistosomiasis is considered a neglected tropical disease. However, since the new millennium, interventions against schistosomiasis are escalating. The initial impetus stems from a 2001 World Health Assembly resolution, urging member states to scale-up deworming of school-aged children with the anthelminthic drug praziquantel. Because praziquantel is safe, efficacious and inexpensive when delivered through the school platform, diagnosis before drug intervention was deemed unnecessary and not cost-effective. Hence, there was little interest in research and development of novel diagnostic tools. With the recent publication of the World Health Organization (WHO) Roadmap to overcome the impact of neglected tropical diseases in 2020, we have entered a new era. Elimination of schistosomiasis has become the buzzword and this has important ramifications for diagnostic tools. Indeed, measuring progress towards the WHO Roadmap and whether local elimination has been achieved requires highly accurate diagnostic assays. Here, we introduce target product profiles for diagnostic tools that are required for different stages of a schistosomiasis control programme. We provide an update of the latest developments in schistosomiasis diagnosis, including microscopic techniques, rapid diagnostic tests for antigen detection, polymerase chain reaction (PCR) assays and proxy markers for morbidity assessments. Particular emphasis is placed on challenges and solutions for new technologies to enter clinical practice.

  16. Aquaculture, husbandry, and shipping at the Zebrafish International Resource Center.

    PubMed

    Varga, Z M

    2016-01-01

    This chapter provides an overview of the Zebrafish International Resource Center (ZIRC) aquaculture systems, husbandry, and live fish shipping methods. The ZIRC has a recirculating water system with mechanical and biological filtration in its main fish facility, and a flow-through water system for its quarantine room. I describe basic husbandry methods for breeding, rearing larvae, feeding and shipping of fish. Whereas the procedures presented here are merely an overview and only the most essential methods are included, they offer starting points to set up, develop, refine, or troubleshoot methods in other fish facilities. PMID:27443942

  17. The ESRC: A Web-based Environmental Satellite Resource Center

    NASA Astrophysics Data System (ADS)

    Abshire, W. E.; Guarente, B.; Dills, P. N.

    2009-12-01

    The COMET® Program has developed an Environmental Satellite Resource Center (known as the ESRC), a searchable, database-driven Website that provides easy access to a wide range of useful information training materials on polar-orbiting and geostationary satellites. Primarily sponsored by the NPOESS Program and NOAA, the ESRC is a tool for users seeking reliable sources of satellite information, training, and data. First published in September 2008, and upgraded in April 2009, the site is freely available at: http://www.meted.ucar.edu/esrc. Additional contributions to the ESRC are sought and made on an ongoing basis. The ESRC was created in response to a broad community request first made in May 2006. The COMET Program was asked to develop the site to consolidate and simplify access to reliable, current, and diverse information, training materials, and data associated with environmental satellites. The ESRC currently includes over 400 significant resources from NRL, CIMSS, CIRA, NASA, VISIT, NESDIS, and EUMETSAT, and improves access to the numerous satellite resources available from COMET’s MetEd Website. The ESRC is designed as a community site where organizations and individuals around the globe can easily submit their resources via online forms by providing a small set of metadata. The ESRC supports languages other than English and multi-lingual character sets have been tested. COMET’s role is threefold: 1) maintain the site, 2) populate it with our own materials, including smaller, focused learning objects derived from our larger training modules, and 3) provide the necessary quality assurance and monitoring to ensure that all resources are appropriate and well described before being made available. Our presentation will demonstrate many of the features and functionality of searching for resources using the ESRC, and will outline the steps for users to make their own submissions. For the site to reach its full potential, submissions representing diverse

  18. Education resources of the National Center for Biotechnology Information.

    PubMed

    Cooper, Peter S; Lipshultz, Dawn; Matten, Wayne T; McGinnis, Scott D; Pechous, Steven; Romiti, Monica L; Tao, Tao; Valjavec-Gratian, Majda; Sayers, Eric W

    2010-11-01

    The National Center for Biotechnology Information (NCBI) hosts 39 literature and molecular biology databases containing almost half a billion records. As the complexity of these data and associated resources and tools continues to expand, so does the need for educational resources to help investigators, clinicians, information specialists and the general public make use of the wealth of public data available at the NCBI. This review describes the educational resources available at NCBI via the NCBI Education page (www.ncbi.nlm.nih.gov/Education/). These resources include materials designed for new users, such as About NCBI and the NCBI Guide, as well as documentation, Frequently Asked Questions (FAQs) and writings on the NCBI Bookshelf such as the NCBI Help Manual and the NCBI Handbook. NCBI also provides teaching materials such as tutorials, problem sets and educational tools such as the Amino Acid Explorer, PSSM Viewer and Ebot. NCBI also offers training programs including the Discovery Workshops, webinars and tutorials at conferences. To help users keep up-to-date, NCBI produces the online NCBI News and offers RSS feeds and mailing lists, along with a presence on Facebook, Twitter and YouTube.

  19. Database resources of the National Center for Biotechnology Information: update

    PubMed Central

    Wheeler, David L.; Church, Deanna M.; Edgar, Ron; Federhen, Scott; Helmberg, Wolfgang; Madden, Thomas L.; Pontius, Joan U.; Schuler, Gregory D.; Schriml, Lynn M.; Sequeira, Edwin; Suzek, Tugba O.; Tatusova, Tatiana A.; Wagner, Lukas

    2004-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI’s website. NCBI resources include Entrez, PubMed, PubMed Central, LocusLink, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, SARS Coronavirus Resource, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov. PMID:14681353

  20. 34 CFR 656.1 - What is the National Resource Centers Program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR FOREIGN LANGUAGE AND AREA STUDIES OR FOREIGN LANGUAGE AND INTERNATIONAL STUDIES General § 656.1 What is the National Resource Centers Program? Under the National Resource Centers Program for Foreign Language and Areas Studies...

  1. 34 CFR 656.1 - What is the National Resource Centers Program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE CENTERS PROGRAM FOR FOREIGN LANGUAGE AND AREA STUDIES OR FOREIGN LANGUAGE AND INTERNATIONAL STUDIES General § 656.1 What is the National Resource Centers Program? Under the National Resource Centers Program for Foreign Language and Areas Studies...

  2. 76 FR 40384 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... of Committee: National Center for Research Resources Special Emphasis Panel, NCRR Animal Resource... HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed... Person: Lee Warren Slice, PhD, Scientific Review Officer, Office of Review, National Center for...

  3. CAISE: A NSF Resource Center for Informal Science Education

    NASA Astrophysics Data System (ADS)

    Dickow, Benjamin

    2012-01-01

    Informal science education (ISE) is playing an increasingly important role in how and where the public engages with science. A growing body of research is showing that people learn the majority of their science knowledge outside of school (Falk & Dierking, 2010). The ISE field includes a wide variety of sources, including the internet, TV programs, magazines, hobby clubs and museums. These experiences touch large numbers of people throughout their lifetimes. If you would like to share your research with the public, ISE can be an effective conduit for meaningful science communication. However, because the ISE field is so diverse, it can be overwhelming with its multiple entry points. If you already are part of an ISE initiative, knowing how to access the most useful resources easily can also be daunting. CAISE, the Center for Advancement of Informal Science Education, is a resource center for the ISE field funded by the National Science Foundation (NSF). CAISE can help connect you to the knowledge and people of ISE, through its website, products and in-person convenings. The proposed CAISE presentation will outline the diversity of the field and concisely present data that will make the case for the impact of ISE. We will focus on examples of successful programs that connect science with the public and that bring together AAS's science research community with practitioners and researchers within ISE. Pathways to various ISE resources in the form of current CAISE initiatives will be described as well. The presentation will include an interview section in which a CAISE staff member will ask questions of a scientist involved in an ISE initiative in order to detail one example of how ISE can be a valuable tool for engaging the public in science. Time for audience Q&A also will be included in the session.

  4. Fluor Hanford ALARA Center is a D and D Resource

    SciTech Connect

    Waggoner, L.O.

    2008-01-15

    II. The ALARA Center staff routinely researches and tests new technology, sponsor vendor demonstrations, and redistribute tools, equipment and temporary shielding that may not be needed at one facility to another facility that needs it. The ALARA Center staff learns about new technology in several ways. This includes past radiological work experience, interaction with vendors, lessons learned, networking with other DOE sites, visits to the Hanford Technical Library, attendance at off-site conferences and ALARA Workshops. Personnel that contact the ALARA Center for assistance report positive results when they implement the tools, equipment and work practices recommended by the ALARA Center staff. This has translated to reduced exposure for workers and reduced the risk of contamination spread. For example: using a hydraulic shear on one job saved 16 Rem of exposure that would have been received if workers had used saws-all tools to cut piping in twenty-nine locations. Currently, the ALARA Center staff is emphasizing D and D techniques on size-reducing materials, decontamination techniques, use of remote tools/video equipment, capture ventilation, fixatives, using containments and how to find lessons learned. The ALARA Center staff issues a weekly report that discusses their interaction with the workforce and any new work practices, tools and equipment being used by the Hanford contractors. Distribution of this weekly report is to about 130 personnel on site and 90 personnel off site. This effectively spreads the word about ALARA throughout the DOE Complex. DOE EM-23, in conjunction with the D and D and Environmental Restoration work group of the Energy Facility Contractors Organization (EFCOG) established the Hanford ALARA Center as the D and D Hotline for companies who have questions about how D and D work is accomplished. The ALARA Center has become a resource to the nuclear industry and routinely helps contractors at other DOE Sites, power reactors, DOD sites, and

  5. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Wheeler, David L.; Barrett, Tanya; Benson, Dennis A.; Bryant, Stephen H.; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M.; DiCuccio, Michael; Edgar, Ron; Federhen, Scott; Geer, Lewis Y.; Helmberg, Wolfgang; Kapustin, Yuri; Kenton, David L.; Khovayko, Oleg; Lipman, David J.; Madden, Thomas L.; Maglott, Donna R.; Ostell, James; Pruitt, Kim D.; Schuler, Gregory D.; Schriml, Lynn M.; Sequeira, Edwin; Sherry, Stephen T.; Sirotkin, Karl; Souvorov, Alexandre; Starchenko, Grigory; Suzek, Tugba O.; Tatusov, Roman; Tatusova, Tatiana A.; Wagner, Lukas; Yaschenko, Eugene

    2006-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Retroviral Genotyping Tools, HIV-1, Human Protein Interaction Database, SAGEmap, Gene Expression Omnibus, Entrez Probe, GENSAT, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of the resources can be accessed through the NCBI home page at: . PMID:16381840

  6. Database resources of the National Center for Biotechnology Information.

    PubMed

    2016-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank(®) nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (PubMed Central (PMC), Bookshelf and PubReader), health (ClinVar, dbGaP, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen), genomes (BioProject, Assembly, Genome, BioSample, dbSNP, dbVar, Epigenomics, the Map Viewer, Nucleotide, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser and the Trace Archive), genes (Gene, Gene Expression Omnibus (GEO), HomoloGene, PopSet and UniGene), proteins (Protein, the Conserved Domain Database (CDD), COBALT, Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB) and Protein Clusters) and chemicals (Biosystems and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for most of these databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:26615191

  7. Database resources of the National Center for Biotechnology Information

    PubMed Central

    2015-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (Bookshelf, PubMed Central (PMC) and PubReader); medical genetics (ClinVar, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen); genes and genomics (BioProject, BioSample, dbSNP, dbVar, Epigenomics, Gene, Gene Expression Omnibus (GEO), Genome, HomoloGene, the Map Viewer, Nucleotide, PopSet, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser, Trace Archive and UniGene); and proteins and chemicals (Biosystems, COBALT, the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB), Protein Clusters, Protein and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for many of these databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov. PMID:25398906

  8. Database resources of the National Center for Biotechnology Information.

    PubMed

    2015-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank(®) nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (Bookshelf, PubMed Central (PMC) and PubReader); medical genetics (ClinVar, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen); genes and genomics (BioProject, BioSample, dbSNP, dbVar, Epigenomics, Gene, Gene Expression Omnibus (GEO), Genome, HomoloGene, the Map Viewer, Nucleotide, PopSet, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser, Trace Archive and UniGene); and proteins and chemicals (Biosystems, COBALT, the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB), Protein Clusters, Protein and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for many of these databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov.

  9. Database resources of the National Center for Biotechnology Information.

    PubMed

    2016-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank(®) nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (PubMed Central (PMC), Bookshelf and PubReader), health (ClinVar, dbGaP, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen), genomes (BioProject, Assembly, Genome, BioSample, dbSNP, dbVar, Epigenomics, the Map Viewer, Nucleotide, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser and the Trace Archive), genes (Gene, Gene Expression Omnibus (GEO), HomoloGene, PopSet and UniGene), proteins (Protein, the Conserved Domain Database (CDD), COBALT, Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB) and Protein Clusters) and chemicals (Biosystems and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for most of these databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov.

  10. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Sayers, Eric W.; Barrett, Tanya; Benson, Dennis A.; Bolton, Evan; Bryant, Stephen H.; Canese, Kathi; Chetvernin, Vyacheslav; Church, Deanna M.; DiCuccio, Michael; Federhen, Scott; Feolo, Michael; Fingerman, Ian M.; Geer, Lewis Y.; Helmberg, Wolfgang; Kapustin, Yuri; Landsman, David; Lipman, David J.; Lu, Zhiyong; Madden, Thomas L.; Madej, Tom; Maglott, Donna R.; Marchler-Bauer, Aron; Miller, Vadim; Mizrachi, Ilene; Ostell, James; Panchenko, Anna; Phan, Lon; Pruitt, Kim D.; Schuler, Gregory D.; Sequeira, Edwin; Sherry, Stephen T.; Shumway, Martin; Sirotkin, Karl; Slotta, Douglas; Souvorov, Alexandre; Starchenko, Grigory; Tatusova, Tatiana A.; Wagner, Lukas; Wang, Yanli; Wilbur, W. John; Yaschenko, Eugene; Ye, Jian

    2011-01-01

    In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI Web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central (PMC), Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Primer-BLAST, COBALT, Electronic PCR, OrfFinder, Splign, ProSplign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, dbVar, Epigenomics, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Trace Archive, Sequence Read Archive, Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART), IBIS, Biosystems, Peptidome, OMSSA, Protein Clusters and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:21097890

  11. Database resources of the National Center for Biotechnology Information

    PubMed Central

    2016-01-01

    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. Additional NCBI resources focus on literature (PubMed Central (PMC), Bookshelf and PubReader), health (ClinVar, dbGaP, dbMHC, the Genetic Testing Registry, HIV-1/Human Protein Interaction Database and MedGen), genomes (BioProject, Assembly, Genome, BioSample, dbSNP, dbVar, Epigenomics, the Map Viewer, Nucleotide, Probe, RefSeq, Sequence Read Archive, the Taxonomy Browser and the Trace Archive), genes (Gene, Gene Expression Omnibus (GEO), HomoloGene, PopSet and UniGene), proteins (Protein, the Conserved Domain Database (CDD), COBALT, Conserved Domain Architecture Retrieval Tool (CDART), the Molecular Modeling Database (MMDB) and Protein Clusters) and chemicals (Biosystems and the PubChem suite of small molecule databases). The Entrez system provides search and retrieval operations for most of these databases. Augmenting many of the web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of these resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. PMID:26615191

  12. Database resources of the National Center for Biotechnology Information

    PubMed Central

    Wheeler, David L.; Barrett, Tanya; Benson, Dennis A.; Bryant, Stephen H.; Canese, Kathi; Church, Deanna M.; DiCuccio, Michael; Edgar, Ron; Federhen, Scott; Helmberg, Wolfgang; Kenton, David L.; Khovayko, Oleg; Lipman, David J.; Madden, Thomas L.; Maglott, Donna R.; Ostell, James; Pontius, Joan U.; Pruitt, Kim D.; Schuler, Gregory D.; Schriml, Lynn M.; Sequeira, Edwin; Sherry, Steven T.; Sirotkin, Karl; Starchenko, Grigory; Suzek, Tugba O.; Tatusov, Roman; Tatusova, Tatiana A.; Wagner, Lukas; Yaschenko, Eugene

    2005-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data retrieval systems and computational resources for the analysis of data in GenBank and other biological data made available through NCBI's website. NCBI resources include Entrez, Entrez Programming Utilities, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD) and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized datasets. All of the resources can be accessed through the NCBI home page at http://www.ncbi.nlm.nih.gov. PMID:15608222

  13. Database resources of the National Center for Biotechnology

    PubMed Central

    Wheeler, David L.; Church, Deanna M.; Federhen, Scott; Lash, Alex E.; Madden, Thomas L.; Pontius, Joan U.; Schuler, Gregory D.; Schriml, Lynn M.; Sequeira, Edwin; Tatusova, Tatiana A.; Wagner, Lukas

    2003-01-01

    In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, PubMed, PubMed Central (PMC), LocusLink, the NCBITaxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR (e-PCR), Open Reading Frame (ORF) Finder, References Sequence (RefSeq), UniGene, HomoloGene, ProtEST, Database of Single Nucleotide Polymorphisms (dbSNP), Human/Mouse Homology Map, Cancer Chromosome Aberration Project (CCAP), Entrez Genomes and related tools, the Map Viewer, Model Maker (MM), Evidence Viewer (EV), Clusters of Orthologous Groups (COGs) database, Retroviral Genotyping Tools, SAGEmap, Gene Expression Omnibus (GEO), Online Mendelian Inheritance in Man (OMIM), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), and the Conserved Domain Architecture Retrieval Tool (CDART). Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov. PMID:12519941

  14. Argonne's Laboratory computing resource center : 2006 annual report.

    SciTech Connect

    Bair, R. B.; Kaushik, D. K.; Riley, K. R.; Valdes, J. V.; Drugan, C. D.; Pieper, G. P.

    2007-05-31

    Argonne National Laboratory founded the Laboratory Computing Resource Center (LCRC) in the spring of 2002 to help meet pressing program needs for computational modeling, simulation, and analysis. The guiding mission is to provide critical computing resources that accelerate the development of high-performance computing expertise, applications, and computations to meet the Laboratory's challenging science and engineering missions. In September 2002 the LCRC deployed a 350-node computing cluster from Linux NetworX to address Laboratory needs for mid-range supercomputing. This cluster, named 'Jazz', achieved over a teraflop of computing power (10{sup 12} floating-point calculations per second) on standard tests, making it the Laboratory's first terascale computing system and one of the 50 fastest computers in the world at the time. Jazz was made available to early users in November 2002 while the system was undergoing development and configuration. In April 2003, Jazz was officially made available for production operation. Since then, the Jazz user community has grown steadily. By the end of fiscal year 2006, there were 76 active projects on Jazz involving over 380 scientists and engineers. These projects represent a wide cross-section of Laboratory expertise, including work in biosciences, chemistry, climate, computer science, engineering applications, environmental science, geoscience, information science, materials science, mathematics, nanoscience, nuclear engineering, and physics. Most important, many projects have achieved results that would have been unobtainable without such a computing resource. The LCRC continues to foster growth in the computational science and engineering capability and quality at the Laboratory. Specific goals include expansion of the use of Jazz to new disciplines and Laboratory initiatives, teaming with Laboratory infrastructure providers to offer more scientific data management capabilities, expanding Argonne staff use of national

  15. Argonne's Laboratory Computing Resource Center 2009 annual report.

    SciTech Connect

    Bair, R. B.

    2011-05-13

    Now in its seventh year of operation, the Laboratory Computing Resource Center (LCRC) continues to be an integral component of science and engineering research at Argonne, supporting a diverse portfolio of projects for the U.S. Department of Energy and other sponsors. The LCRC's ongoing mission is to enable and promote computational science and engineering across the Laboratory, primarily by operating computing facilities and supporting high-performance computing application use and development. This report describes scientific activities carried out with LCRC resources in 2009 and the broad impact on programs across the Laboratory. The LCRC computing facility, Jazz, is available to the entire Laboratory community. In addition, the LCRC staff provides training in high-performance computing and guidance on application usage, code porting, and algorithm development. All Argonne personnel and collaborators are encouraged to take advantage of this computing resource and to provide input into the vision and plans for computing and computational analysis at Argonne. The LCRC Allocations Committee makes decisions on individual project allocations for Jazz. Committee members are appointed by the Associate Laboratory Directors and span a range of computational disciplines. The 350-node LCRC cluster, Jazz, began production service in April 2003 and has been a research work horse ever since. Hosting a wealth of software tools and applications and achieving high availability year after year, researchers can count on Jazz to achieve project milestones and enable breakthroughs. Over the years, many projects have achieved results that would have been unobtainable without such a computing resource. In fiscal year 2009, there were 49 active projects representing a wide cross-section of Laboratory research and almost all research divisions.

  16. Hepatic and Intestinal Schistosomiasis: Review

    PubMed Central

    Elbaz, Tamer; Esmat, Gamal

    2013-01-01

    Schistosomiasis is an endemic disease in Egypt caused by the trematode Schistosoma which has different species. Hepatic schistosomiasis represents the best known form of chronic disease with a wide range of clinical manifestations. The pathogenesis of schistosomiasis is related to the host cellular immune response. This leads to granuloma formation and neo angiogenesis with subsequent periportal fibrosis manifested as portal hypertension, splenomegaly and esophageal varices. Intestinal schistosomiasis is another well identified form of chronic schistosomal affection. Egg deposition and granuloma formation eventually leads to acute then chronic schistosomal colitis and is commonly associated with polyp formation. It frequently presents as abdominal pain, diarrhea, tenesmus and anal pain. Definite diagnosis of schistosomiasis disease depends on microscopy and egg identification. Marked progress regarding serologic diagnosis occurred with development of recent PCR techniques that can confirm schistosomal affection at any stage. Many antischistosomal drugs have been described for treatment, praziquantel being the most safe and efficient drug. Still ongoing studies try to develop effective vaccines with identification of many target antigens. Preventive programs are highly needed to control the disease morbidity and to break the cycle of transmission. PMID:25685451

  17. Still hope for schistosomiasis vaccine.

    PubMed

    Ricciardi, Alessandra; Ndao, Momar

    2015-01-01

    Schistosomiasis is a parasitic disease caused by helminths belonging to the Schistosoma genus. Approximately 700 million people are at risk of infection and 200 million people are currently infected. Schistosomiasis is the most important helminth infection, and treatment relies solely on the drug praziquantel. Worries of praziquantel resistance as well as high disease burden are only some of the justifications which support the development of a vaccine against schistosomiasis. To date, only 2 schistosome vaccines have made it into clinical trials: Sh28GST (Bilhvax) and Sm14. However, there are several vaccine candidates, such as TSP-2, sm-p8, and Sm-Cathepsin B, which are generating promising results in pre-clinical studies. Schistosomiasis vaccine development has been an uphill battle, and there are still several hurdles to overcome in the future. Fortunately, the research groups involved in the research for vaccine development have not abandoned their work. Furthermore, in the last few years, schistosomiasis has garnered some additional attention on a global scale due to its significant impact on public health.

  18. Hydrogen Data Book from the Hydrogen Analysis Resource Center

    DOE Data Explorer

    The Hydrogen Data Book contains a wide range of factual information on hydrogen and fuel cells (e.g., hydrogen properties, hydrogen production and delivery data, and information on fuel cells and fuel cell vehicles), and it also provides other data that might be useful in analyses of hydrogen infrastructure in the United States (e.g., demographic data and data on energy supply and/or infrastructure). ItÆs made available from the Hydrogen Analysis Resource Center along with a wealth of related information. The related information includes guidelines for DOE Hydrogen Program Analysis, various calculator tools, a hydrogen glossary, related websites, and analysis tools relevant to hydrogen and fuel cells. [From http://hydrogen.pnl.gov/cocoon/morf/hydrogen

  19. Technology for independence: a community-based resource center.

    PubMed

    Blanck, Peter; Ritchie, Heather; Schmeling, James; Klein, David

    2003-01-01

    Despite the prominence of the disability civil rights model--with its values of inclusion and empowerment--the majority of social and policy research conducted to date has not sufficiently included the perspective of persons with disabilities in the research process and as uniquely qualified researchers themselves. This article describes a new project, "Technology for Independence: A Community-Based Resource Center" (CBRC). Over a five-year period, the CBRC will attempt to enhance community and consumer-directed disability organizations to design, implement, and disseminate research that promotes access to and use of assistive technology (AT). The CBRC will use strategies such as leadership training, participatory action research, technical assistance, web-assisted training, and annual symposia. A primary goal of the CBRC is to increase the capacity of community organizations to conduct research on AT that is scientifically rigorous and relevant to disability services, policy, and law.

  20. Resource allocation in academic health centers: creating common metrics.

    PubMed

    Joiner, Keith A; Castellanos, Nathan; Wartman, Steven A

    2011-09-01

    Optimizing resource allocation is essential for effective academic health center (AHC) management, yet guidelines and principles for doing so in the research and educational arenas remain limited. To address this issue, the authors analyzed responses to the 2007-2008 Association of Academic Health Centers census using ratio analysis. The concept was to normalize data from an individual institution to that same institution, by creating a ratio of two separate values from the institution (e.g., total faculty FTEs/total FTEs). The ratios were then compared across institutions. Generally, this strategy minimizes the effect of institution size on the responses, size being the predominant limitation of using absolute values for developing meaningful metrics. In so doing, ratio analysis provides a range of responses that can be displayed in graphical form to determine the range and distribution of values. The data can then be readily scrutinized to determine where any given institution falls within the distribution. Staffing ratios and operating ratios from up to 54 institutions are reported. For ratios including faculty numbers in the numerator or denominator, the range of values is wide and minimally discriminatory, reflecting heterogeneity across institutions in faculty definitions. Values for financial ratios, in particular total payroll expense/total operating expense, are more tightly clustered, reflecting in part the use of units with a uniform definition (i.e., dollars), and emphasizing the utility of such ratios in decision guidelines. The authors describe how to apply these insights to develop metrics for resource allocation in the research and educational arenas. PMID:21785307

  1. Resource allocation in academic health centers: creating common metrics.

    PubMed

    Joiner, Keith A; Castellanos, Nathan; Wartman, Steven A

    2011-09-01

    Optimizing resource allocation is essential for effective academic health center (AHC) management, yet guidelines and principles for doing so in the research and educational arenas remain limited. To address this issue, the authors analyzed responses to the 2007-2008 Association of Academic Health Centers census using ratio analysis. The concept was to normalize data from an individual institution to that same institution, by creating a ratio of two separate values from the institution (e.g., total faculty FTEs/total FTEs). The ratios were then compared across institutions. Generally, this strategy minimizes the effect of institution size on the responses, size being the predominant limitation of using absolute values for developing meaningful metrics. In so doing, ratio analysis provides a range of responses that can be displayed in graphical form to determine the range and distribution of values. The data can then be readily scrutinized to determine where any given institution falls within the distribution. Staffing ratios and operating ratios from up to 54 institutions are reported. For ratios including faculty numbers in the numerator or denominator, the range of values is wide and minimally discriminatory, reflecting heterogeneity across institutions in faculty definitions. Values for financial ratios, in particular total payroll expense/total operating expense, are more tightly clustered, reflecting in part the use of units with a uniform definition (i.e., dollars), and emphasizing the utility of such ratios in decision guidelines. The authors describe how to apply these insights to develop metrics for resource allocation in the research and educational arenas.

  2. The Center for Computational Biology: resources, achievements, and challenges.

    PubMed

    Toga, Arthur W; Dinov, Ivo D; Thompson, Paul M; Woods, Roger P; Van Horn, John D; Shattuck, David W; Parker, D Stott

    2012-01-01

    The Center for Computational Biology (CCB) is a multidisciplinary program where biomedical scientists, engineers, and clinicians work jointly to combine modern mathematical and computational techniques, to perform phenotypic and genotypic studies of biological structure, function, and physiology in health and disease. CCB has developed a computational framework built around the Manifold Atlas, an integrated biomedical computing environment that enables statistical inference on biological manifolds. These manifolds model biological structures, features, shapes, and flows, and support sophisticated morphometric and statistical analyses. The Manifold Atlas includes tools, workflows, and services for multimodal population-based modeling and analysis of biological manifolds. The broad spectrum of biomedical topics explored by CCB investigators include the study of normal and pathological brain development, maturation and aging, discovery of associations between neuroimaging and genetic biomarkers, and the modeling, analysis, and visualization of biological shape, form, and size. CCB supports a wide range of short-term and long-term collaborations with outside investigators, which drive the center's computational developments and focus the validation and dissemination of CCB resources to new areas and scientific domains.

  3. Argonne Laboratory Computing Resource Center - FY2004 Report.

    SciTech Connect

    Bair, R.

    2005-04-14

    In the spring of 2002, Argonne National Laboratory founded the Laboratory Computing Resource Center, and in April 2003 LCRC began full operations with Argonne's first teraflops computing cluster. The LCRC's driving mission is to enable and promote computational science and engineering across the Laboratory, primarily by operating computing facilities and supporting application use and development. This report describes the scientific activities, computing facilities, and usage in the first eighteen months of LCRC operation. In this short time LCRC has had broad impact on programs across the Laboratory. The LCRC computing facility, Jazz, is available to the entire Laboratory community. In addition, the LCRC staff provides training in high-performance computing and guidance on application usage, code porting, and algorithm development. All Argonne personnel and collaborators are encouraged to take advantage of this computing resource and to provide input into the vision and plans for computing and computational analysis at Argonne. Steering for LCRC comes from the Computational Science Advisory Committee, composed of computing experts from many Laboratory divisions. The CSAC Allocations Committee makes decisions on individual project allocations for Jazz.

  4. The chronic enteropathogenic disease schistosomiasis.

    PubMed

    Olveda, David U; Olveda, Remigio M; McManus, Donald P; Cai, Pengfei; Chau, Thao N P; Lam, Alfred K; Li, Yuesheng; Harn, Donald A; Vinluan, Marilyn L; Ross, Allen G P

    2014-11-01

    Schistosomiasis is a chronic enteropathogenic disease caused by blood flukes of the genus Schistosoma. The disease afflicts approximately 240 million individuals globally, causing approximately 70 million disability-adjusted life years lost. Chronic infections with morbidity and mortality occur as a result of granuloma formation in the intestine, liver, or in the case of Schistosoma haematobium, the bladder. Various methods are utilized to diagnose and evaluate liver fibrosis due to schistosomiasis. Liver biopsy is still considered the gold standard, but it is invasive. Diagnostic imaging has proven to be an invaluable method in assessing hepatic morbidity in the hospital setting, but has practical limitations in the field. The potential of non-invasive biological markers, serum antibodies, cytokines, and circulating host microRNAs to diagnose hepatic fibrosis is presently undergoing evaluation. This review provides an update on the recent advances made with respect to gastrointestinal disease associated with chronic schistosomiasis.

  5. How To Develop a Resource Center for a Career Education Program.

    ERIC Educational Resources Information Center

    Eversole, Opal

    Intended to guide local school systems in the development of a resource center for a career education program, this booklet identifies three kinds of resources which should be included: Human resources, community resources, and material resources. Then in a question/answer format, the guide explains the basic steps in identifying all resources…

  6. Argonne's Laboratory Computing Resource Center : 2005 annual report.

    SciTech Connect

    Bair, R. B.; Coghlan, S. C; Kaushik, D. K.; Riley, K. R.; Valdes, J. V.; Pieper, G. P.

    2007-06-30

    Argonne National Laboratory founded the Laboratory Computing Resource Center in the spring of 2002 to help meet pressing program needs for computational modeling, simulation, and analysis. The guiding mission is to provide critical computing resources that accelerate the development of high-performance computing expertise, applications, and computations to meet the Laboratory's challenging science and engineering missions. The first goal of the LCRC was to deploy a mid-range supercomputing facility to support the unmet computational needs of the Laboratory. To this end, in September 2002, the Laboratory purchased a 350-node computing cluster from Linux NetworX. This cluster, named 'Jazz', achieved over a teraflop of computing power (10{sup 12} floating-point calculations per second) on standard tests, making it the Laboratory's first terascale computing system and one of the fifty fastest computers in the world at the time. Jazz was made available to early users in November 2002 while the system was undergoing development and configuration. In April 2003, Jazz was officially made available for production operation. Since then, the Jazz user community has grown steadily. By the end of fiscal year 2005, there were 62 active projects on Jazz involving over 320 scientists and engineers. These projects represent a wide cross-section of Laboratory expertise, including work in biosciences, chemistry, climate, computer science, engineering applications, environmental science, geoscience, information science, materials science, mathematics, nanoscience, nuclear engineering, and physics. Most important, many projects have achieved results that would have been unobtainable without such a computing resource. The LCRC continues to improve the computational science and engineering capability and quality at the Laboratory. Specific goals include expansion of the use of Jazz to new disciplines and Laboratory initiatives, teaming with Laboratory infrastructure providers to develop

  7. Rocky Mountain Regional Resource Center: An Overview. Volume I of III. Final Report.

    ERIC Educational Resources Information Center

    Buffmire, Judy Ann

    The first of three volumes on the Rocky Mountain Regional Resource Center provides an overview of the Center's functioning from its inception in 1970 through 1974. A perspective is provided on regional resource centers (RRC) in general, including such aspects as the educational system's link to an RRC and the relationship of the RRC to the…

  8. NASA Space Engineering Research Center for utilization of local planetary resources

    NASA Technical Reports Server (NTRS)

    Ramohalli, Kumar; Lewis, John S.

    1990-01-01

    The University of Arizona and NASA have joined to form the UA/NASA Space Engineering Research Center. The purpose of the Center is to discover, characterize, extract, process, and fabricate useful products from the extraterrestrial resources available in the inner solar system (the moon, Mars, and nearby asteroids). Individual progress reports covering the center's research projects are presented and emphasis is placed on the following topics: propellant production, oxygen production, ilmenite, lunar resources, asteroid resources, Mars resources, space-based materials processing, extraterrestrial construction materials processing, resource discovery and characterization, mission planning, and resource utilization.

  9. Use of Indicator Kriging to Investigate Schistosomiasis in Minas Gerais State, Brazil

    PubMed Central

    Guimarães, Ricardo J. P. S.; Freitas, Corina C.; Dutra, Luciano V.; Felgueiras, Carlos A.; Drummond, Sandra C.; Tibiriçá, Sandra H. C.; Oliveira, Guilherme; Carvalho, Omar S.

    2012-01-01

    Geographic Information Systems (GISs) are composed of useful tools to map and to model the spatial distribution of events that have geographic importance as schistosomiasis. This paper is a review of the use the indicator kriging, implemented on the Georeferenced Information Processing System (SPRING) to make inferences about the prevalence of schistosomiasis and the presence of the species of Biomphalaria, intermediate hosts of Schistosoma mansoni, in areas without this information, in the Minas Gerais State, Brazil. The results were two maps. The first one was a map of Biomphalaria species, and the second was a new map of estimated prevalence of schistosomiasis. The obtained results showed that the indicator kriging can be used to better allocate resources for study and control of schistosomiasis in areas with transmission or the possibility of disease transmission. PMID:22291716

  10. Significance and future role of microbial resource centers.

    PubMed

    Overmann, Jörg

    2015-06-01

    Isolated strains constitute the basis for microbial systematics as well as for numerous applications in biotechnology, pharmacology, agronomy and public health. Microbial resource centers (mBRCs) are institutions capable of safeguarding, maintaining and distributing authenticated microbial strains, their genomic DNA and the associated data in a quality-controlled manner. They allow the deposit and distribution of type strains that form the basis of microbial taxonomy. Beyond taxonomy, deposited strains enable follow-up scientific studies and lead to a significantly improved recognition of scientific work. Considerable added value is generated through the labor-intensive steps of enrichment, enrichment screening, isolation, characterization, conservation and long-term storage of microbial strains. Here, a microbial strain is calculated to attain a value of 9836 Euro through its isolation and another 918 Euro through its deposit, adding up to a total value of 10,754 Euro. mBRCs provide a highly cost-effective way of preserving this value of microbial strains. A considerable future challenge of mBRCs will be to secure a larger fraction of strains that are isolated in research labs worldwide. mBRCs provide the expert knowledge and the cultivation and preservation skills crucial to access the large fraction of uncharted microbial diversity. mBRCs also provide the expertise and support the depositors of microbial resources to meet new legal challenges after implementation of the Nagoya Protocol. A suitable roadmap is described that allows mBRCs to meet the new demands emerging in science, technology and economy through an integration of novel technology, expansion of their duties and establishing an improved global mBRC network.

  11. Schistosomiasis collection at NHM (SCAN)

    PubMed Central

    2012-01-01

    Background The Natural History Museum (NHM) is developing a repository for schistosomiasis-related material, the Schistosomiasis Collection at NHM (SCAN) as part of its existing Wolfson Wellcome Biomedical Laboratory (WWBL). This is timely because a major research and evaluation effort to understand control and move towards elimination of schistosomiasis in Africa has been initiated by the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE), resulting in the collection of many important biological samples, including larval schistosomes and snails. SCAN will collaborate with a number of research groups and control teams and the repository will acquire samples relevant to both immediate and future research interest. The samples collected through ongoing research and field activities, WWBL’s existing collections, and other acquisitions will be maintained over the long term and made available to the global research community for approved research purposes. Goals include: · Consolidation of the existing NHM schistosome and snail collections and transfer of specimens into suitable long-term storage systems for DNA retrieval, · Long-term and stable storage of specimens collected as part of on going field programmes initially in Africa especially relating to the SCORE research programmes, · Provision of access to snail and schistosome collections for approved research activities. PMID:22943137

  12. Amarillo National Resource Center for Plutonium. Quarterly technical progress report, May 1, 1997--July 31, 1997

    SciTech Connect

    1997-09-01

    Progress summaries are provided from the Amarillo National Center for Plutonium. Programs include the plutonium information resource center, environment, public health, and safety, education and training, nuclear and other material studies.

  13. The Right Stuff: Essential Resources for Managing Your Middle School Media Center.

    ERIC Educational Resources Information Center

    Manczuk, Suzanne

    1999-01-01

    Describes the following resources for managing a middle school media center: literature bibliographies with on-target middle school recommendations and useful annotations; resources for teaching primary sources; resources on censorship and banned books; basic Internet guides; copyright-law resources; information-literacy standards; and…

  14. An Instructional Resource Center in a Senior Dental Clinic.

    ERIC Educational Resources Information Center

    Berrong, Joseph M.; And Others

    1982-01-01

    Development of an instructional materials center and self-instructional materials on clinical dental procedures is described. The center is located near students' operatories and the student-tested programs were developed cost-effectively and relatively quickly. (MSE)

  15. National Maternal and Child Oral Health Resource Center

    MedlinePlus

    ... pregnant women, infants, children, adolescents, and their families. Fluoride Varnish: A Resource Guide (2nd ed.) This resource ... provides information about the use and application of fluoride varnish, including materials and organizations. Promoting Oral Health ...

  16. Developing a Resource Center in Consumer Education: An Annotated Bibliography.

    ERIC Educational Resources Information Center

    Garman, E. Thomas; And Others

    The rationale behind this annotated bibliography of over 1300 items is that every consumer education teacher needs numerous classroom resources to provide for the individual needs of his students, and these resources should be balanced in representing all content areas. The resource materials included, mostly booklets and pamphlets for classroom…

  17. Selected Resources for Drug Information Centers. Selected Reference Series 8, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    This listing of books, periodicals, organizations, and other resources in the field of drug abuse was compiled in response to requests by information centers for a guide into a large and expanding field. The resources should be helpful to both a new information center and an established one planning expansion. Not all materials are considered…

  18. Information Resources on Microcomputer Applications for Media Centers. A Selected ERIC Bibliography.

    ERIC Educational Resources Information Center

    McLaughlin, Pamela, Comp.

    Citations in this annotated bibliography were selected from the Educational Resources Information Center (ERIC) indexes, Current Index to Journals in Education (CIJE), and Resources in Education (RIE). Titles include: (1) "Computer Applications in the Library Media Center: An Introduction to Electronic Spreadsheets" (Keith E. Bernhard); (2)…

  19. 34 CFR 464.32 - How is a regional literacy resource center established and operated?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false How is a regional literacy resource center established... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM How Does a State Award Contracts? § 464.32 How is a regional literacy...

  20. 34 CFR 464.32 - How is a regional literacy resource center established and operated?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false How is a regional literacy resource center established... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM How Does a State Award Contracts? § 464.32 How is a regional literacy...

  1. 34 CFR 464.32 - How is a regional literacy resource center established and operated?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false How is a regional literacy resource center established... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM How Does a State Award Contracts? § 464.32 How is a regional literacy...

  2. 34 CFR 464.32 - How is a regional literacy resource center established and operated?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false How is a regional literacy resource center established... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM How Does a State Award Contracts? § 464.32 How is a regional literacy...

  3. 34 CFR 464.32 - How is a regional literacy resource center established and operated?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false How is a regional literacy resource center established... Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY RESOURCE CENTERS PROGRAM How Does a State Award Contracts? § 464.32 How is a regional literacy...

  4. Child care centers: a community resource for injury prevention.

    PubMed

    Stuy, M; Green, M; Doll, J

    1993-08-01

    Child passenger safety, a major public health concern, has been addressed by state laws mandating use of child restraint devices. Usage rates in poor and minority communities are disproportionately low. To determine the influence of the child care center within these communities to improve routine use, an educational clinical trial, based on social learning theory was designed. Two urban child care centers enrolling high-risk 2- through 6-year-old children were monitored for correct child restraint use during a 5-month educational intervention at one center. Key features of intervention programming included weekly, developmentally appropriate presentations by the staff to the children and documented parental awareness of the child care center's policy advisory regarding child restraint use. Results demonstrate statistically significant (p < .01) increases in use at the intervention center. This study finds that child care center policy and programming can be effective in promoting child passenger safety.

  5. Schistosomiasis in Travelers and Expatriates.

    PubMed

    Jelinek; Nothdurft; Löscher

    1996-09-01

    Background: Several outbreaks of schistosomiasis among travelers, expatriates, and military serviceman have been reported in recent years. Methods: The travel histories and anamnestic and clinical features of 62 patients with schistosomiasis, who presented to a German outpatient clinic specializing in infectious and tropical diseases, were investigated to identify risk factors that could lead to infection in travelers and expatriates. Results: All patients remembered incidents that led to a likely exposure to cercariae of Schistosoma sp. Fifty nine patients (95%) acquired infection in Africa, two (3%) in South America, and one each (2% each) in Iraq and the Mekong River, respectively. The highest proportion of infection (45%) was imported from West Africa. Patients returning from West Africa reported either contact with tributaries of the Niger (including freshwater pools in the Dogon country, Mali) or with waters of the Volta River, notably Lake Volta and/or its delta. Six patients (10%) acquired infection in little-visited areas such as Central Africa and the Congo Basin. East Africa (especially Lake Victoria) and Lake Malawi contributed 14 patients (22%) to our study group; a further nine patients (14%) became infected after contact with waters of the Zambezi River. Conclusions: The most sensitive method for detection of possible infection with schistosomiasis appeared to be a combination of thorough travel history and serologic testing by indirect hemagglutination (IHA), immunofluorescence antibody test (IFAT), and enzyme-linked immunosorbent assay (ELISA). Most infections were acquired by travelers on lengthy and adventurous journeys or by expatriates venturing outside their normal areas of activity. Most patients knew that they had traveled in an area endemic for schistosomiasis, but were uninformed about behavioral risks they had taken in specific settings. PMID:9815445

  6. Schistosomiasis in Travelers and Expatriates.

    PubMed

    Jelinek; Nothdurft; Löscher

    1996-09-01

    Background: Several outbreaks of schistosomiasis among travelers, expatriates, and military serviceman have been reported in recent years. Methods: The travel histories and anamnestic and clinical features of 62 patients with schistosomiasis, who presented to a German outpatient clinic specializing in infectious and tropical diseases, were investigated to identify risk factors that could lead to infection in travelers and expatriates. Results: All patients remembered incidents that led to a likely exposure to cercariae of Schistosoma sp. Fifty nine patients (95%) acquired infection in Africa, two (3%) in South America, and one each (2% each) in Iraq and the Mekong River, respectively. The highest proportion of infection (45%) was imported from West Africa. Patients returning from West Africa reported either contact with tributaries of the Niger (including freshwater pools in the Dogon country, Mali) or with waters of the Volta River, notably Lake Volta and/or its delta. Six patients (10%) acquired infection in little-visited areas such as Central Africa and the Congo Basin. East Africa (especially Lake Victoria) and Lake Malawi contributed 14 patients (22%) to our study group; a further nine patients (14%) became infected after contact with waters of the Zambezi River. Conclusions: The most sensitive method for detection of possible infection with schistosomiasis appeared to be a combination of thorough travel history and serologic testing by indirect hemagglutination (IHA), immunofluorescence antibody test (IFAT), and enzyme-linked immunosorbent assay (ELISA). Most infections were acquired by travelers on lengthy and adventurous journeys or by expatriates venturing outside their normal areas of activity. Most patients knew that they had traveled in an area endemic for schistosomiasis, but were uninformed about behavioral risks they had taken in specific settings.

  7. The Ethnic Heritage Learning Resource Center, 1975-1976.

    ERIC Educational Resources Information Center

    Hennessy, James J.

    The Ethnic Heritage Learning Center, designed to increase the reading skills of elementary students who are educationally and economically disadvantaged, is described in this paper. The major goal of the Center was to provide supplementary remedial reading instruction. In addition to the 250 students who were selected as a target group, the Center…

  8. Student-Centered Integrated Anatomy Resource Sessions at Alfaisal University

    ERIC Educational Resources Information Center

    Cowan, Michele; Arain, Nasir Nisar; Assale, Tawfic Samer Abu; Assi, Abdulelah Hassan; Albar, Raed Alwai; Ganguly, Paul K.

    2010-01-01

    Alfaisal University is a new medical school in Riyadh, Kingdom of Saudi Arabia that matriculates eligible students directly from high school and requires them to participate in a hybrid problem-based learning (PBL) curriculum. PBL is a well-established student-centered approach, and the authors have sought to examine if a student-centered,…

  9. Resource-Based Intervention: Success with Community-Centered Practices

    ERIC Educational Resources Information Center

    Torrey, Michelle Kerber; Leginus, Mary Anne; Cecere, Susan

    2011-01-01

    In this commentary the authors share their experiences on the design and implementation of community-centered early intervention programs in Prince George's County, MD. Their aim in designing community-centered programs was to provide infants and toddlers opportunities for learning, language, and motor development in natural environments with…

  10. Math Notes. The Clipboard Connection. Chapter I Resource Center Curriculum and Instruction.

    ERIC Educational Resources Information Center

    Advanced Technology, Inc., Indianapolis, IN.

    The "Clipboard Connection" is a methodology to facilitate the rapid circulation of relevant pre-existing materials from Chapter 1 Technical Assistance Centers of relevant materials from Chapter 1 Technical Assistance Centers (TACs) to their clients, teachers of educationally disadvantaged children in resource centers. Each "Clipboard Connection"…

  11. Constructing Student Learning through Faculty Development: Writing Experts, Writing Centers, and Faculty Resources

    ERIC Educational Resources Information Center

    Werner, Courtney L.

    2013-01-01

    In this article, the author explains how a writing center can be a potential host for housing writing instruction across the disciplines. She recommends writing centers act as hosts for various faculty development opportunities throughout the semester, and states that these centers can also hold faculty development resources and collaborative…

  12. Conquering schistosomiasis in China: the long march.

    PubMed

    Utzinger, Jürg; Zhou, Xiao-Nong; Chen, Ming-Gang; Bergquist, Robert

    2005-01-01

    The last half-century of schistosomiasis control activities in China have brought down the overall prevalence of human infection with Schistosoma japonicum to less than 10% of the level initially documented in the mid 1950s. Importantly, this reduction is not only, or even mainly, due to the advent of praziquantel in the 1970s and its subsequent dramatic fall in price. Instead, it is the result of a sustained, multifaceted national strategy, adapted to different eco-epidemiological settings, which has been versatile enough to permit subtle adjustments over time as the nature of the challenge changed. Consequently, prevalence has been falling relatively smoothly over the whole period rather than suddenly dropping when mass chemotherapy became feasible. Thus, early recognition of the huge public health and economic significance of the disease, and the corresponding political will to do something about it,underpinned this success. In addition, intersectoral collaboration and community participation played important roles in forming a sustained commitment to a working control strategy based on local resources. The unfolding story is presented from the early years' strong focus on snail control, by means of environmental management, to the last period of praziquantel-based morbidity control carried out under the 10-year World Bank Loan Project (WBLP). An important legacy of the WBLP is the understanding that a research component would sustain control measures and enable future progress. We are now witnessing the payoffs of this forward thinking in the form of a new promising class of drugs, improved diagnostics, and budding vaccine development in addition to novel ways of disease risk prediction and transmission control using satellite-based remote sensing. Different aspects of social and economic approaches are also covered and the importance of health promotion and education is emphasized. Issuing from the review is a set of recommendations, which might further

  13. In Vivo MRI Assessment of Experimental Schistosomiasis.

    PubMed

    Lambertucci, José Roberto; Mamede, Marcelo; Pereira, Thiago A

    2016-01-01

    A new study using magnetic resonance imaging (MRI) evaluated successfully the transverse relaxation time T2 as a non-invasive imaging biomarker for monitoring hepatic fibrogenesis in schistosomiasis. However, there are some drawbacks that need special attention. This preliminary data opens new opportunities to understand and monitor liver fibrosis in schistosomiasis and other fibrogenic diseases.

  14. Schistosomiasis in non-endemic countries.

    PubMed

    Coltart, Cordelia; Whitty, Christopher J M

    2015-02-01

    Schistosomiasis is one of the major parasitic diseases of the tropics, causing acute and long-term clinical syndromes. Almost all schistosomiasis is now imported from sub-Saharan Africa. This article summarises the aetiology, clinical presentation, diagnosis and management of schistosomiaisis for clinicians in non-endemic countries.

  15. [Post-transmission Schistosomiasis: the Problem of Hepatic Fibrosis].

    PubMed

    Wang, Yong

    2015-12-01

    Hepatic fibrosis caused by schistosomiasis japonica is becoming an important issue in areas when the transmission of schitosomiasis has been interrupted. Schistosomiasis control programme should therefore be adjusted to involve the routine monitoring and intervention of hepatic fibrosis of schistosomiasis in those areas with effective transmission control, to inhibit the development of advanced schistosomiasis.

  16. A Cross-sectional Serological Study of Cysticercosis, Schistosomiasis, Toxocariasis and Echinococcosis in HIV-1 Infected People in Beira, Mozambique

    PubMed Central

    Noormahomed, Emilia Virginia; Nhacupe, Noémia; Mascaró-Lazcano, Carmen; Mauaie, Manuel Natane; Buene, Titos; Funzamo, Carlos Abel; Benson, Constance Ann

    2014-01-01

    Background Helminthic infections are highly endemic in Mozambique, due to limited access to healthcare and resources for disease prevention. Data on the subclinical prevalence of these diseases are scarce due to the fact that an immunological and imaging diagnosis is not often available in endemic areas. We conducted a cross-sectional study on HIV1+ patients from Beira city in order to determine the seroprevalence of cysticercosis, schistosomiasis, toxocariasis and echinoccocosis and its possible interaction with HIV infection. Methodology/Principal Findings Patients (601) were voluntarily recruited at the Ponta Gea Health Center and their demographic and clinical data were recorded (including CD4+ cell count and antiretroviral regimen). Mean age was 39.7 years, 378 (62.9%) were women and 223 (37.1%) were men. Four hundred seventy-five (475) patients (79%) were already on highly active antiretroviral therapy (HAART), and 90 started therapy after being enrolled in the study. For serological testing we used a Multiplex Western Blot IgG from LDBIO Diagnostics. The overall seroprevalence was 10.2% for cysticercosis, 23% for schistosomiasis, 7.3% for toxocariasis and 17.3% for echinococcosis. Conclusions/Significance Neither age nor the CD4+ count were significantly associated with the seroprevalence of the helminths studied. However, patients with CD4+ between 200–500/µl had a higher seroprevalence to all helminths than those with less than 200/µl cells/and those with more than 500 cells/µl. Female gender was significantly associated with cysticercosis and schistosomiasis, and being in HAART with toxocariasis. Headache was significantly associated with cysticercosis and toxocariasis. There was no association between epilepsy and seropositivity to any of the parasites. The study concluded that a clear understanding of the prevalence and manifestations of these coinfections, how best to diagnose subclinical cases, and how to manage diseases with concomitant

  17. Maternal schistosomiasis: a growing concern in sub-Saharan Africa

    PubMed Central

    Salawu, Oyetunde T; Odaibo, Alexander B

    2014-01-01

    Schistosomiasis remains one of the most important tropical parasitic infections threatening millions of lives in endemic areas. Cases of infections due to Schistosoma spp, the diecious digenetic trematodes have been on the increase over the last decades. While considerable efforts have been made to reduce infections and morbidities in most endemic areas, these efforts seem to be tailored only towards a specific group (school-based resources). This bias towards school children in epidemiological studies has also been observed in various research efforts in sub-Saharan Africa, thus making it difficult to produce a reliable estimate of the extent of infection in other strata of the population at risk. In recent times, attention has been drawn to Schistosoma spp infections in infants and preschool children, while studies on epidemiology of maternal schistosomiasis still suffer neglect. Considering the potential morbidity of Schistosoma infections on the mothers, fetuses, and neonates, as evidenced in some animal models and human case studies, more attention is solicited in all areas of observational studies and clinical trials, for maternal schistosomiasis with the aim of providing relevant data and information for effective management of the disease during pregnancy. PMID:25223633

  18. Educational Resources Information Center (ERIC) File Partition Study: Final Report.

    ERIC Educational Resources Information Center

    Hull, Cynthia C.; Wanger, Judith

    A study to provide the National Center for Educational Communication (NCE) with information that could be useful in making the ERIC data base more relevant to the needs of educators and more efficiently usable by them is discussed. Specific purposes of this project were to use an empirical field-survey study as an armature around which to: (1)…

  19. Is a Materials Resource Center Right for You?

    ERIC Educational Resources Information Center

    Peters, Tom

    2004-01-01

    When a commercial pilot steps into the cockpit of an airplane, it has been serviced by a host of personnel and will be supported by many more from takeoff to landing. In more and more places, when an elementary school teacher steps into inquiry-centered science instruction, his or her materials have been carefully prepared by a team of experts,…

  20. A New Reference Resource: The Interactive Media Center.

    ERIC Educational Resources Information Center

    Pilkington, Laura A.

    1993-01-01

    Reviews the literature on the cost effectiveness of computer-assisted instruction in libraries and describes a case study of the Interactive Media Center at the State University of New York at Albany that shows continuously increasing use. Useful applications of interactive multimedia are described, and suggestions for further research are…

  1. Library Schools: Resource Laboratories for School Media Centers.

    ERIC Educational Resources Information Center

    Main, Linda

    1987-01-01

    Discusses the development of automated management systems for school library media centers. Suggests that schools of library and information science establish microcomputer laboratories containing state-of-the-art library management software and hardware that could be used for field work, inservices, and conferences. (TW)

  2. Catalog: Wilmington College Peace Resource Center. Revised Edition.

    ERIC Educational Resources Information Center

    Wilmington Coll., OH. Peace Resource Center.

    A bibliography of low-cost peace education resources for individuals and organizations, this catalogue lists audio-visual materials, archival materials, and books. The audio-visual materials and the books are grouped into some or all of the following categories: atomic bombings, nuclear war, the arms race, anti-war, civil defense, peace education,…

  3. Human Schistosomiasis: Clinical Perspective: Review

    PubMed Central

    Barsoum, Rashad S.; Esmat, Gamal; El-Baz, Tamer

    2013-01-01

    The clinical manifestations of schistosomiasis pass by acute, sub acute and chronic stages that mirror the immune response to infection. The later includes in succession innate, TH1 and TH2 adaptive stages, with an ultimate establishment of concomitant immunity. Some patients may also develop late complications, or suffer the sequelae of co-infection with other parasites, bacteria or viruses. Acute manifestations are species-independent; occur during the early stages of invasion and migration, where infection-naivety and the host’s racial and genetic setting play a major role. Sub acute manifestations occur after maturity of the parasite and settlement in target organs. They are related to the formation of granulomata around eggs or dead worms, primarily in the lower urinary tract with Schistosoma haematobium, and the colon and rectum with Schistosoma mansoni, Schistosoma japonicum, Schistosoma intercalatum and Schistosoma mekongi infection. Secondary manifestations during this stage may occur in the kidneys, liver, lungs or other ectopic sites. Chronic morbidity is attributed to the healing of granulomata by fibrosis and calcification at the sites of oval entrapment, deposition of schistosomal antigen-antibody complexes in the renal glomeruli or the development of secondary amyloidosis. Malignancy may complicate the chronic lesions in the urinary bladder or colon. Co-infection with salmonella or hepatitis viruses B or C may confound the clinical picture of schistosomiasis, while the latter may have a negative impact on the course of other co-infections as malaria, leishmaniasis and HIV. Prevention of schistosomiasis is basically geared around education and periodic mass treatment, an effective vaccine being still experimental. Praziquantel is the drug of choice in the treatment of active infection by any species, with a cure rate of 80%. Other antischistosomal drugs include metrifonate for S. haematobium, oxamniquine for S. mansoni and Artemether and, possibly

  4. [Schistosomiasis endemic in Burkina Faso].

    PubMed

    Poda, J N; Traoré, A; Sondo, B K

    2004-02-01

    Burkina Faso, through the works of many teams of the OCCGE based in Bobo-Dioulasso, has signi-ficant data on several tropical endemics of which schistosomiasis. With the complementary works, it appears to be possible to establish a distribution of the schistosomiasis which reveals its importance. It will be the first stage of the planned national control program. The parasitologic data-gathering which covers the period of 1951 to 2000, used all the standard techniques. It is about Kato-Kartz and MIF for the intestinal schistosomiasis, centrifugation, filtration, serology reagent strips, macroscopy of urines and echography of the urinary system for the urinary schistosomiasis. All the eleven medical areas of the country have many sites submitted to parasitologic investigation. As regard the distribution of the two parasites involved with man (Schistosoma haematobium and S. mansoni), the data of prevalence (1% to 100%) and their distribution confirm their endemicity and the focal transmission. S. mansoni is located in eight medical areas particularly in the South and the West. S. haematobium is present in all the eleven medical areas of the country. In hydraulic planning as Sourou where the prevalences went from 23% to 70% for S. haematobium and from 0% to 69% for S. mansoni between 1987 and 1998. The situation requires a continuous monitoring. The spatial distribution of the six species of intermediate hosts shows that Bulinus truncatus and B. senegalensis Soudano-Sahelian species are present in all the ecological zones. B. globosus and Biomphalaria pfeifferi meet preferentially in the southern half of the country which reinforces the observation according to which the 14th northern parallel is often considered as the limit of septentrional extension of these two species. The other species Bulinus forskalii and B umbilicatus could have preference areas. All the species show a certain affinity with a type of biotope. The rarity and temporary aquatic systems lead to a

  5. Web application for simplifying access to computer center resources and information.

    2013-05-01

    Lorenz is a product of the ASC Scientific Data Management effort. Lorenz is a web-based application designed to help computer centers make information and resources more easily available to their users.

  6. Amarillo National Resource Center for Plutonium quarterly technical progress report, August 1--October 31, 1998

    SciTech Connect

    1998-11-01

    This paper describes activities of the Center under the following topical sections: Electronic resource library; Environmental restoration and protection; Health and safety; Waste management; Communication program; Education program; Training; Analytical development; Materials science; Plutonium processing and handling; and Storage.

  7. Amarillo National Resource Center for Plutonium. Quarterly technical progress report, February 1, 1998--April 30, 1998

    SciTech Connect

    1998-06-01

    Activities from the Amarillo National Resource Center for Plutonium are described. Areas of work include materials science of nuclear and explosive materials, plutonium processing and handling, robotics, and storage.

  8. 15 CFR 291.4 - National industry-specific pollution prevention and environmental compliance resource centers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... sources of information which will be used to create the informational foundation of the resource center... sources will be external. Factors that may be considered include: Strength of core competency in...

  9. 15 CFR 291.4 - National industry-specific pollution prevention and environmental compliance resource centers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... sources of information which will be used to create the informational foundation of the resource center... sources will be external. Factors that may be considered include: Strength of core competency in...

  10. Use of IKONOS Data for Mapping Cultural Resources of Stennis Space Center, Mississippi

    NASA Technical Reports Server (NTRS)

    Spruce, Joseph P.; Giardino, Marco

    2002-01-01

    Cultural resource surveys are important for compliance with Federal and State law. Stennis Space Center (SSC) in Mississippi is researching, developing, and validating remote sensing and Geographical Information System (GIS) methods for aiding cultural resource assessments on the center's own land. The suitability of IKONOS satellite imagery for georeferencing scanned historic maps is examined in this viewgraph presentation. IKONOS data can be used to map historic buildings and farmland in Gainsville, MS, and plan archaeological surveys.

  11. 34 CFR 464.30 - With whom must a State contract to establish a State literacy resource center?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... literacy resource center? 464.30 Section 464.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY... establish a State literacy resource center? (a) To establish a new State literacy resource center,...

  12. 34 CFR 464.30 - With whom must a State contract to establish a State literacy resource center?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... literacy resource center? 464.30 Section 464.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY... establish a State literacy resource center? (a) To establish a new State literacy resource center,...

  13. 34 CFR 464.30 - With whom must a State contract to establish a State literacy resource center?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... literacy resource center? 464.30 Section 464.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY... establish a State literacy resource center? (a) To establish a new State literacy resource center,...

  14. 34 CFR 464.30 - With whom must a State contract to establish a State literacy resource center?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... literacy resource center? 464.30 Section 464.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY... establish a State literacy resource center? (a) To establish a new State literacy resource center,...

  15. 34 CFR 464.30 - With whom must a State contract to establish a State literacy resource center?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... literacy resource center? 464.30 Section 464.30 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE LITERACY... establish a State literacy resource center? (a) To establish a new State literacy resource center,...

  16. Parents and Instruction. The Clipboard Connection. Chapter I Resource Center Curriculum and Instruction.

    ERIC Educational Resources Information Center

    Advanced Technology, Inc., Indianapolis, IN.

    The "Clipboard Connection" is a methodology to facilitate the rapid circulation of relevant pre-existing materials from Chapter 1 Technical Assistance Centers (TACs) to their clients, teachers of educationally disadvantaged children in resource centers. Each "Clipboard Connection" consists of a lead sheet summarizing the contents of the materials…

  17. Products Available. The Clipboard Connection. Chapter I Resource Center Curriculum and Instruction.

    ERIC Educational Resources Information Center

    Advanced Technology, Inc., Indianapolis, IN.

    The "Clipboard Connection" is a methodology to facilitate the rapid circulation of relevant pre-existing materials from Chapter 1 Technical Assistance Centers (TACs) to their clients, teachers of educationally disadvantaged children in resource centers. Each "Clipboard Connection" consists of a lead sheet summarizing the contents of the materials…

  18. The Reading Writing Connection. The Clipboard Connection. Chapter I Resource Center Curriculum and Instruction.

    ERIC Educational Resources Information Center

    Advanced Technology, Inc., Indianapolis, IN.

    The "Clipboard Connection" is a methodology to facilitate the rapid circulation of relevant pre-existing materials from Chapter 1 Technical Assistance Centers (TACs) to their clients, teachers of educationally disadvantaged children in resource centers. Each "Clipboard Connection" consists of a lead sheet summarizing the contents of the materials…

  19. Florida Community College at Jacksonville's Donald D. Zell Urban Resource Center.

    ERIC Educational Resources Information Center

    Florida Community Coll., Jacksonville. Urban Resource Center.

    The Donald D. Zell Urban Resource Center (URC) represents Florida Community College at Jacksonville's (FCCJ) commitment to a quality workforce for Northeast Florida. Through the use of state-of-the-art technology and progressive instructional methods, the Center is helping FCCJ students expand their potential and their value in the workplace. The…

  20. 76 FR 28443 - National Center for Research Resources; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Washingtonian Center, which was published in the Federal Register on May 3, 2011, 76 FR 85, page 24890. The... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Amended Notice...

  1. Using Language Corpora to Develop a Virtual Resource Center for Business English

    ERIC Educational Resources Information Center

    Ngo, Thi Phuong Le

    2015-01-01

    A Virtual Resource Center (VRC) has been brought into use since 2008 as an integral part of a task-based language teaching and learning program for Business English courses at Nantes University, France. The objective of the center is to enable students to work autonomously and individually on their language problems so as to improve their language…

  2. Teaching Ideas. The Clipboard Connection. Chapter I Resource Center Curriculum and Instruction.

    ERIC Educational Resources Information Center

    Advanced Technology, Inc., Indianapolis, IN.

    The "Clipboard Connection" is a methodology to facilitate the rapid circulation of relevant pre-existing materials from Chapter 1 Technical Assistance Centers (TACs) to their clients, teachers of educationally disadvantaged children in resource centers. Each "Clipboard Connection" consists of a lead sheet summarizing the contents of the materials…

  3. Feasibility Study of Resource-Use, Outdoor Education Center, Taylor County, Florida.

    ERIC Educational Resources Information Center

    Master Enterprises, Athens, GA.

    Extensive planning in relation to the establishment of an outdoor education center in the State of Florida is reported. The proposed outdoor education center, designed to enrich the public school program if instruction in such fields as conservation, recreation, and resource-use, is outlined. The report contains an account of socioeconomic…

  4. 77 FR 72868 - The Centers for Disease Control (CDC)/Health Resources and Services Administration (HRSA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ... HUMAN SERVICES Centers for Disease Control and Prevention The Centers for Disease Control (CDC)/Health Resources and Services Administration (HRSA) Advisory Committee on HIV, Viral Hepatitis and STD Prevention... (Pub. L. 92-463) of October 6, 1972, that the CDC/HRSA Advisory Committee on HIV, Viral Hepatitis...

  5. Indiana Career Resource Center. Annual Report. July 1, 1972-June 30, 1973.

    ERIC Educational Resources Information Center

    Indiana Univ., South Bend. Indiana Career Resource Center.

    A historical overview is given in the fourth annual report of the Indiana Career Resource Center. The Center has been involved in a variety of activities throughout the State, covering school activities, consultation programs; loaning of instructional materials, school workshops; interaction within the community, and publications and productions.…

  6. Special Education Diagnostic and Resource Center Project, 1967-68. ESEA Title III Evaluation Report.

    ERIC Educational Resources Information Center

    Wichita Unified School District 259, KS.

    The project provided for the 2nd year of operation of a special education diagnostic and resource center, special classes, and supportive services for handicapped children and youth between the ages of 3 and 21. Cooperation was obtained from existing community agencies, participating school districts, and local private practitioners. Center staff…

  7. The schistosomiasis problem in Nigeria.

    PubMed

    Ejezie, G C; Gemade, E I; Utsalo, S J

    1989-01-01

    Schistosomiasis is endemic in Nigeria as revealed by several prevalence studies but the degree of endemicity is low. The proliferation of several irrigation projects all over the country has stabilized the infection in Northern Nigeria while in the West rapid urbanisation, supply of portable water and mass chemotherapy have combined to reduce the prevalence rates. Human infection is measured by the determination of incidence, prevalence and intensity of infection. Heavy infections can rapidly be detected by use of urinalysis reagent strips to measure haematuria and protein levels in urine. The prevalence of severe pathological forms of the disease is very low and schistosomiasis is not associated with bacteriuria or hypertension in Nigeria, although isolated cases of ectopic lesions of the genitalis and uterus have been reported. Nodular filling defects occur early during infection, while bladder calcification comes at a later stage. The severity of the disease is related to the intensity of infection. Clinical trials with metrifonate and niridazole among other drugs have been carried out, with varying results. A new drug, praziquantel has been assessed and found suitable for mass use. Three methods of control include adequate provision of safe water, selective or targeted mass chemotherapy and use of molluscicides to kill the snails. Each method has its advantages and drawbacks, but the therapeutic approach is cheap, effects quicker result and treats the infected patients. PMID:2504814

  8. Amarillo National Resource Center for Plutonium quarterly technical progress report, August 1, 1997--October 31, 1997

    SciTech Connect

    1997-12-31

    This report summarizes activities of the Amarillo National Resource Center for Plutonium during the quarter. The report describes the Electronic Resource Library; DOE support activities; current and future environmental health and safety programs; pollution prevention and pollution avoidance; communication, education, training, and community involvement programs; and nuclear and other material studies, including plutonium storage and disposition studies.

  9. Amarillo National Resource Center for Plutonium quarterly technical progress report, February 1--April 30, 1997

    SciTech Connect

    1997-06-01

    This report contains short summaries of the activities carried out under the umbrella of the Amarillo National Resource Center for Plutonium. Studies are related to the Plutonium Information Resource; advisory functions; environmental, public health and safety; communication, education, and training; and nuclear and other material studies. Approximately 40 report summaries are presented. Several detailed reports are also included.

  10. ERIC Annual Report-1988. Summarizing the Accomplishments of the Educational Resources Information Center.

    ERIC Educational Resources Information Center

    Krekeler, Nancy A.; Stonehill, Robert M.; Thomas, Robert L.

    This is the second in a series of annual reports summarizing the activities and accomplishments of the Educational Resources Information Center (ERIC) program, which is funded and managed by the Office of Educational Resources and Improvement in the U.S. Department of Education. The report begins by presenting background information on ERIC's…

  11. 34 CFR 656.3 - What activities define a comprehensive or undergraduate National Resource Center?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false What activities define a comprehensive or undergraduate National Resource Center? 656.3 Section 656.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE...

  12. 34 CFR 656.3 - What activities define a comprehensive or undergraduate National Resource Center?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false What activities define a comprehensive or undergraduate National Resource Center? 656.3 Section 656.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE...

  13. 34 CFR 656.3 - What activities define a comprehensive or undergraduate National Resource Center?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What activities define a comprehensive or undergraduate National Resource Center? 656.3 Section 656.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION NATIONAL RESOURCE...

  14. 75 FR 49498 - National Center for Research Resources; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Meeting... hereby given of a meeting of the National Advisory Research Resources Council. The meeting will be open... accommodations, should notify the Contact Person listed below in advance of the meeting. The meeting will...

  15. Strategizing for the Future: Evolving Cultural Resource Centers in Higher Education

    ERIC Educational Resources Information Center

    Shek, Yen Ling

    2013-01-01

    Cultural resource centers have been an ongoing and integral component to creating a more welcoming campus climate for Students of Color since its establishment in the 1960s. While the racial dynamics may have changed, many of the challenges Students of Color faced on predominantly White campuses have not. Interestingly, cultural resource centers…

  16. Providing consumer health information in the rural setting: Planetree Health Resource Center's approach

    PubMed Central

    Spatz, Michele A.

    2000-01-01

    Both lifestyle and geography make the delivery of consumer health information in the rural setting unique. The Planetree Health Resource Center in The Dalles, Oregon, has served the public in a rural setting for the past eight years. It is a community-based consumer health library, affiliated with a small rural hospital, Mid-Columbia Medical Center. One task of providing consumer health information in rural environments is to be in relationship with individuals in the community. Integration into community life is very important for credibility and sustainability. The resource center takes a proactive approach and employs several different outreach efforts to deepen its relationship with community members. It also works hard to foster partnerships for improved health information delivery with other community organizations, including area schools. This paper describes Planetree Health Resource Center's approach to rural outreach. PMID:11055307

  17. [Schistosomiasis Control in Sub-Saharan Africa. Proceedings of a round table, Lisbon, Portugal, September 9, 2002].

    PubMed

    2004-02-01

    The Round Table organized by the Société de pathologie exotique during the 3rd European Congress on Tropical medicine and International Health held in Lisbon on September 9, 2002 has been attended by a hundred participants. Five communications were presented and followed by a debate concerning the main aspects of the epidemiology and the control of schistosomiasis in sub-Saharan Africa. The necessity of studying intermediate hosts to identify vectors, some of which being able to colonize new areas or to modify their susceptibility to parasites, has been emphasized. The population is infected during water contacts and Poda et al. showed the importance of water projects, necessary for the development of poor countries, but facilitating the transmission of schistosomiasis. Most current activities force the population to use stagnant water However, it is well known that children are more infected, with severe clinical and functional consequences. The contamination of the environment is linked to hygienic practices. Sow et al. demonstrated that usually recommended solutions are inappropriate. Latrines, for example, are notably sub-used by some at risk groups because culturally unsuitable and considered as avoiding discretion or comfort. Besides the technical improvement which can be proposed, education by the parents and the teachers must begin from the youngest age. Ernould et al. showed the strong heterogeneity of schistosomiasis transmission in water projects due notably to the distance between habitations and transmission sites as well as modalities of use and maintenance of the irrigation system. In this respect, the communication of Poda et al. showed that schistosomiasis was underestimated by the health system due to the lack of training of health staff, poor equipment of health centers and low awareness of both populations and political authorities. Garba et al. confirmed the efficiency of mass treatments with praziquantel, even with a low therapeutic coverage

  18. Morbidity control of schistosomiasis in China.

    PubMed

    Qing-Wu, Jiang; Li-Ying, Wang; Jia-Gang, Guo; Ming-Gang, Chen; Xiao-Nong, Zhou; Engels, Dirk

    2002-05-01

    After reviewing the schistosomiasis control program in China with focusing on the socio-economic impact on schistosomiasis endemicity, we introduce the promotion process of morbidity control strategy undertaken before and during the World Bank Loan Project (WBLP) on Schistosomiasis Control. We analyzed the data derived from case study of morbidity control for schistosomiasis, and evaluated the efficacy of chemotherapy. It is suggested that appropriate drug treatment declines worm burden and the intensity of infection as well as prevalence, but chemotherapy alone can hardly reduce the transmission because zoonotic Schistosoma japonicum infection has a great impact on the transmission of the disease. Therefore, the strategies in different (high, medium, and low) transmission areas during the maintenance stage were put forward in consideration of challenges in national control program in the future.

  19. Schistosomiasis: current epidemiology and management in travelers.

    PubMed

    Meltzer, Eyal; Schwartz, Eli

    2013-06-01

    Schistosomiasis is increasingly encountered among travelers returning from the tropics, mainly from Africa. Schistosoma-infected travelers have served as sentinels for the existence of unknown foci of transmission even outside Africa. Acute schistosomiasis (also termed Katayama syndrome) is the common manifestation among travelers and may follow exposure to any of the Schistosoma species. Neuroschistosomiasis is a rare complication but may result in severe disability. Diagnosis in travelers is hampered by the poor sensitivity of microscopy in urine and stool, especially during acute infections, while seroconversion may be delayed for a period of weeks. During acute schistosomiasis, symptomatic treatment is the only available therapy, while for chronic schistosomiasis, praziquantel is the only drug available, despite reports of emerging resistance to it. Since the potential for exposure to Schistosoma through travel will probably continue to increase, it is clear that new, sensitive diagnostic methods and drugs affecting the parasite in all its stages are needed. PMID:23568567

  20. Schistosomiasis therapeutics: whats in the pipeline?

    PubMed

    Trainor-Moss, Santiago; Mutapi, Francisca

    2016-01-01

    Schistosomiasis is a debilitating neglected tropical disease caused by schistosome worms. Global efforts to control schistosomiasis rely predominantly on mass drug administration of the drug praziquantel to populations at risk of infection. We review the history of schistosome drug development and the current position of schistosome drug research. We conclude that with no additional candidates currently in the anti-schistosome drug clinical trial pipeline, a practical and necessary approach is to optimise the health benefits from praziquantel. We offer suggestions of where and how this can be achieved. We also highlight knowledge gaps in the utility of praziquantel particularly in the treatment of chronic schistosomiasis, which includes fibrosis, organomegaly and cervical lesions associated with female genital schistosomiasis.

  1. Drugs for treating urinary schistosomiasis

    PubMed Central

    Kramer, Christine V; Zhang, Fan; Sinclair, David; Olliaro, Piero L

    2014-01-01

    Background Urinary schistosomiasis is caused by an intravascular infection with parasitic Schistosoma haematobium worms. The adult worms typically migrate to the venous plexus of the human bladder and excrete eggs which the infected person passes in their urine. Chronic infection can cause substantial morbidity and long-term complications as the eggs become trapped in human tissues causing inflammation and fibrosis. We summarised evidence of drugs active against the infection. This is new edition of a review first published in 1997. Objectives To evaluate the efficacy and safety of drugs for treating urinary schistosomiasis. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register, MEDLINE, CENTRAL, EMBASE and LILACS and reference lists of articles up to 23 May 2014. Selection criteria Randomized controlled trials (RCTs) of antischistosomal drugs and drug combinations compared to placebo, no intervention, or each other. Data collection and analysis Two researchers independently screened the records, extracted the data and assessed risk of bias. The primary efficacy outcomes were parasitological failure (defined as the continued presence of S. haematobium eggs in the urine at time points greater than one month after treatment), and percent reduction of egg counts from baseline. We presented dichotomous data as risk ratios (RR), and continuous data as mean difference (MD), alongside their 95% confidence intervals (CIs). Where appropriate we combined trials in meta analyses or tables. We assessed the quality of evidence using the GRADE approach. Main results We included 30 RCTs enrolling 8165 participants in this review. Twenty-four trials were conducted in children in sub-Saharan Africa, and 21 trials were over 20 years old. Many studies were assessed as being at unclear risk of bias due to inadequate descriptions of study methods. Praziquantel On average, a single 40 mg/kg dose of praziquantel reduced the proportion of people still

  2. The MMS Science Data Center: Operations, Capabilities, and Resource.

    NASA Astrophysics Data System (ADS)

    Larsen, K. W.; Pankratz, C. K.; Giles, B. L.; Kokkonen, K.; Putnam, B.; Schafer, C.; Baker, D. N.

    2015-12-01

    The Magnetospheric MultiScale (MMS) constellation of satellites completed their six month commissioning period in August, 2015 and began science operations. Science operations for the Solving Magnetospheric Acceleration, Reconnection, and Turbulence (SMART) instrument package occur at the Laboratory for Atmospheric and Space Physics (LASP). The Science Data Center (SDC) at LASP is responsible for the data production, management, distribution, and archiving of the data received. The mission will collect several gigabytes per day of particles and field data. Management of these data requires effective selection, transmission, analysis, and storage of data in the ground segment of the mission, including efficient distribution paths to enable the science community to answer the key questions regarding magnetic reconnection. Due to the constraints on download volume, this includes the Scientist-in-the-Loop program that identifies high-value science data needed to answer the outstanding questions of magnetic reconnection. Of particular interest to the community is the tools and associated website we have developed to provide convenient access to the data, first by the mission science team and, beginning March 1, 2016, by the entire community. This presentation will demonstrate the data and tools available to the community via the SDC and discuss the technologies we chose and lessons learned.

  3. The Information Commons: a model for (physical) digital resource centers.

    PubMed

    Duncan, J M

    1998-10-01

    Since its planning, construction, and opening in 1996, the Information Commons, located in The University of Iowa's Hardin Library for the Health Sciences, has served as a common ground for self-directed learning, information research, hands-on class sessions, and multimedia development. Initiatives launched from the Information Commons not only have helped increase the visibility of Hardin Library as an environment well equipped to support traditional research and education needs, but have promoted the library as a campus leader and viable partner in planning and delivering digital technologies effectively. Ongoing initiatives have focused on better integrating the library's services and resources with the curricula and research needs of the university's health sciences units. This paper describes the facility, its programmatic elements, and its impact on education, communication, and technology trends in an academic health sciences setting. Particular attention is paid to initiatives launched during the first two years of operation. This paper also discusses plans for expansion of the facility. PMID:9803303

  4. National Training Center Fort Irwin expansion area aquatic resources survey

    SciTech Connect

    Cushing, C.E.; Mueller, R.P.

    1996-02-01

    Biologists from Pacific Northwest National Laboratory (PNNL) were requested by personnel from Fort Irwin to conduct a biological reconnaissance of the Avawatz Mountains northeast of Fort Irwin, an area for proposed expansion of the Fort. Surveys of vegetation, small mammals, birds, reptiles, amphibians, and aquatic resources were conducted during 1995 to characterize the populations and habitats present with emphasis on determining the presence of any species of special concern. This report presents a description of the sites sampled, a list of the organisms found and identified, and a discussion of relative abundance. Taxonomic identifications were done to the lowest level possible commensurate with determining the status of the taxa relative to its possible listing as a threatened, endangered, or candidate species. Consultation with taxonomic experts was undertaken for the Coleoptera ahd Hemiptera. In addition to listing the macroinvertebrates found, the authors also present a discussion related to the possible presence of any threatened or endangered species or species of concern found in Sheep Creek Springs, Tin Cabin Springs, and the Amargosa River.

  5. Discriminating acute from chronic human schistosomiasis mansoni.

    PubMed

    Beck, Lílian; Van-Lüme, Daniele S M; Souza, Joelma R; Domingues, Ana L C; Favre, Tereza; Abath, Frederico G C; Montenegro, Silvia M L

    2008-01-01

    Specific immunoglobulin (IgA, IgG and IgM) responses to different antigen targets (soluble eggs antigen--SEA, soluble worm adult protein--SWAP and keyhole limpet hole--KLH) were measured by enzyme linked immunosorbent assay (ELISA) in patients with acute and chronic schistosomiasis, as well as patients without schistosomiasis. SEA IgA and KLH IgM presented high discriminatory powers to distinguish acute from chronic schistosomiasis, with calculated areas under the curve (AUCs) of 0.88 and 0.82, respectively, obtained from receiver operating characteristic (ROC) curve. On the other hand, these tests, particularly SEA IgA were not useful to distinguish schistosomiasis (including the acute and chronic forms) from individuals without this disease, but infected with other intestinal parasites (Ascaris lumbricoides, Trichuris trichiura and hookworm). By contrast, SWAP IgG and SEA IgG were able to discriminate schistosomiasis patients from healthy individuals and patients infected with other parasites (AUCs of 0.96 and 0.85, respectively). Thus, it is possible to use a combination of serological tests, such as SEA IgA and SWAP IgG, to simultaneously establish the diagnosis of schistosomiasis and discriminate the acute from the chronic forms of the disease.

  6. Addressing underutilization of consumer health information resource centers: a formative study*

    PubMed Central

    Kennedy, May G.; Kiken, Laura; Shipman, Jean P.

    2008-01-01

    Problem: Four consumer health information centers in Richmond, Virginia, provide one-on-one assistance in accessing health information. Because they may not be fully utilized at present, an exploratory marketing study of factors affecting usage of the centers was conducted. Method: Observers counted center passers-by and tracked their paths. Also, brief intercept interviews were conducted with people who had just used a center, people nearby who could have used one but did not, and people on the street. Finally, in-depth individual interviews were conducted with key informants. Results: There was a high degree of satisfaction with the centers among users. Nonusers universally endorsed the center concept. However, most passers-by did not even glance at the centers, and intercept interviewees suggested better signage and promoting the resource centers through various media channels. Key informants added suggestions about interpersonal strategies (e.g., physician referrals) for center usage promotion but cautioned that a large increase in traffic could not be accommodated without increasing staff size or shifting from a model of individualized service. Conclusions: Triangulating findings from multiple data collection methods can provide useful guidance for efforts to promote center utilization. At minimum, steps should be taken to make the largest centers more noticeable. Because center utilization is not only associated with consumer satisfaction with hospitals, but may also foster health literacy, both hospital-based and community-based usage promotion strategies may be warranted. All such promotional strategies should be audience-tested before they are adopted. PMID:18219380

  7. Schistosomiasis

    MedlinePlus

    ... zi-a), is a disease caused by parasitic worms. Infection with Schistosoma mansoni, S. haematobium , and S. japonicum causes ... or washing in contaminated water. Within several weeks, worms grow inside the blood vessels of the body ...

  8. Schistosomiasis

    MedlinePlus

    ... can get a schistosoma infection through contact with contaminated water. This parasite swims freely in open bodies ... disease is known to exist Been exposed to contaminated or possibly contaminated bodies of water

  9. Schistosomiasis transmission and environmental change: a spatio-temporal analysis in Porto de Galinhas, Pernambuco - Brazil

    PubMed Central

    2012-01-01

    Background In Brazil, schistosomiasis mansoni infection is an endemic disease that mainly affects the country’s rural populations who carry out domestic and social activities in rivers and water accumulations that provide shelter for the snails of the disease. The process of rural migration to urban centers and the disorderly occupation of natural environments by these populations from endemic areas have favored expansion of schistosomiasis to locations that had been considered to be disease-free. Based on environmental changes that have occurred in consequent to an occupation and urbanization process in the locality of Porto de Galinhas, the present study sought to identify the relationship between those chances, measure by remote-sensing techniques, and establish a new endemic area for schistosomiasis on the coast of Pernambuco State - Brazil. Methods To gather prevalence data, two parasitological census surveys were conducted (2000 and 2010) using the Kato-Katz technique. Two malacological surveys were also conducted in the same years in order to define the density and infection rate of the intermediate host. Based on these data, spatial analyses were done, resulting in maps of the risk of disease transmission. To ascertain the environmental changes that have occurred at the locality, images from the QuickBird satellite were analyzed, thus resulting in land use maps. Results Over this 10-year period, the foci of schistosomiasis became more concentrated in the Salinas district. This area was considered to be at the greatest risk of schistosomiasis transmission and had the highest prevalence rates over this period. The study illustrated that this was the area most affected by the environmental changes resulting from the disorderly urbanization process, which gave rise to unsanitary environments that favored the establishment and maintenance of foci of schistosomiasis transmission, thereby consolidating the process of expansion and endemization of this

  10. Data availability and the role of the earth resources observation systems data center

    NASA Technical Reports Server (NTRS)

    Watkins, A. H.

    1975-01-01

    With the launch of LANDSAT-1 in July 1972, and the follow-on launch of LANDSAT-2 in January of this year, routine availability of satellite imagery and electronic data of the earth's resources has become a reality. Federal data centers provide LANDSAT data to resource managers and the general public. These data centers have to date provided almost 500,000 frames of LANDSAT data at a cost of more than $2,000,000. Data from the LANDSAT satellite program, along with data and information from the Skylab manned program, are available over any location to anyone for the cost of reproduction.

  11. Workshop report: Schistosomiasis vaccine clinical development and product characteristics.

    PubMed

    Mo, Annie X; Colley, Daniel G

    2016-02-17

    A schistosomiasis vaccine meeting was organized to evaluate the utility of a vaccine in public health programs, to discuss clinical development paths, and to define basic product characteristics for desirable vaccines to be used in the context of schistosomiasis control and elimination programs. It was concluded that clinical evaluation of a schistosomiasis vaccine is feasible with appropriate trial design and tools. Some basic Preferred Product Characteristics (PPC) for a human schistosomiasis vaccine and for a veterinary vaccine for bovine use were also proposed.

  12. Testicular Schistosomiasis Mimicking Malignancy in a Child: A Case Report.

    PubMed

    Ekenze, Sebastian O; Modekwe, Victor O; Nzegwu, Martin A; Ekpemo, Samuel C; Ezomike, Uchechukwu O

    2015-08-01

    Schistosomiasis is an important communicable disease in the developing world. However, testicular schistosomiasis is an extremely rare condition. We report a case of testicular schistosomiasis mimicking testicular tumour in a 13 year old who presented with huge unilateral testicular mass. The dilemma encountered in the diagnosis and treatment of this child is presented to highlight the need for high index of suspicion of this pathology in children with testicular mass presenting from schistosomiasis-endemic areas.

  13. 2011 Year in review--Earth Resources Observation and Science Center

    USGS Publications Warehouse

    Johnson, Rebecca

    2012-01-01

    The USGS Earth Resources Observation and Science (EROS) Center's 2011 Year in Review is an annual report recounting the broad scope of the Center's 2011 accomplishments. The report covers preparations for the Landsat Data Continuity Mission (LDCM) launch, the ever-increasing use of free Landsat data, monitoring the effects of natural hazards, and more to emphasize the importance of innovation in using satellite data to study change over time.

  14. Schistosomiasis transmission and control in China.

    PubMed

    Zou, Lan; Ruan, Shigui

    2015-03-01

    In the last 60 years, great progress has been made in controlling and preventing schistosomiasis in China. However, due to the ecosystem changes caused by the construction of the Three Gorges Dams and the South-north Water Conversion Project, the effects of climate change, the scarcity of a highly sensitive surveillance and response system, schistosomiasis is still considered as a major public health problem and is listed among the top infectious diseases in the country prioritized for control and elimination. Based on the epidemiological pattern of schistosomiasis and ecological characteristics of the vector snail, endemic areas of schistosomiasis in China were categorized into three types: (i) plain region with waterway networks, (ii) mountainous and hilly regions, and (iii) marshland and lake regions. China aims to reach the criteria of transmission control threshold of less than 1% in the lake and marshland provinces and reach transmission interruption threshold in hilly provinces of Sichuan and Yunnan by the end of 2015. The purpose of this article is to use the deterministic model proposed in our earlier study in (Chen et al., 2010) to simulate the schistosomiasis infection data from other lake and marshland provinces, including Hunan, Jiangxi and Anhui. Our simulations demonstrate that the model can reasonably mimic the schistosomiasis infection data from these lake and marshland provinces. Thus, similar control and prevention measures can be designed and proposed for these provinces. We will also try to use the model to simulate the schistosomiasis infection data from Sichuan and Yunnan provinces in the mountainous and hilly regions where cattle farming is not as popular and important as in the lake and marshland provinces and find out that different control and prevention strategies are required.

  15. Mobilizing Learning Resources in a Transnational Classroom: Translocal and Digital Resources in a Community Technology Center

    ERIC Educational Resources Information Center

    Noguerón-Liu, Silvia

    2014-01-01

    Drawing from transnational and activity theory frameworks, this study analyzes the ways translocal flows shape learning in a community technology center serving adult immigrants in the US Southwest. It also explores students' constructions of the transnational nature of the courses they took, where they had access to both online and…

  16. A new asset for pathogen informatics--the Enteropathogen Resource Integration Center (ERIC), an NIAID Bioinformatics Resource Center for Biodefense and Emerging/Re-emerging Infectious Disease.

    PubMed

    Greene, John M; Plunkett, Guy; Burland, Valerie; Glasner, Jeremy; Cabot, Eric; Anderson, Brad; Neeno-Eckwall, Eric; Qiu, Yu; Mau, Bob; Rusch, Michael; Liss, Paul; Hampton, Thomas; Pot, David; Shaker, Matthew; Shaull, Lorie; Shetty, Panna; Shi, Chuan; Whitmore, Jon; Wong, Mary; Zaremba, Sam; Blattner, Frederick R; Perna, Nicole T

    2007-01-01

    ERIC (Enteropathogen Resource Information Center) is one of the National Institute of Allergy and Infectious Diseases (NIAID) Bioinformatics Resource Centers for Biodefense and Emerging/Re-emerging Infectious Disease. ERIC serves as a comprehensive information resource for five related pathogens: Yersinia enterocolitica, Yersinia pestis, diarrheagenic E. coli, Shigella spp., and Salmonella spp. ERIC integrates genomics, proteomics, biochemical and microbiological information to facilitate the interpretation and understanding of ERIC pathogens and select related non-pathogens for the advancement of diagnostics, therapeutics, and vaccines. ERIC (www.ericbrc.org) is evolving to provide state-of-the-art analysis tools and data types, such as genome sequencing, comparative genomics, genome polymorphisms, gene expression, proteomics, and pathways as well as expertly curated community genome annotation. Genome sequence and genome annotation data and a variety of analysis and tools for eight strains of Yersinia enterocolitica and Yersinia pestis pathogens (Yersinia pestis biovars Mediaevalis KIM, Mediaevalis 91001, Orientalis CO92, Orientalis IP275, Antiqua Angola, Antiqua Antiqua, Antiqua Nepal516, and Yersinia enterocolitica 8081) and two strains of Yersinia pseudotuberculosis (Yersinia pseudotuberculosis IP32953 and IP31758) are currently available through the ERIC portal. ERIC seeks to maintain a strong collaboration with the scientific community so that we can continue to identify and incorporate the latest research data, tools, and training to best meet the current and future needs of the enteropathogen research community. All tools and data developed under this NIAID contract will be freely available. Please contact info@ericbrc.org for more information.

  17. Advances in the Diagnosis of Human Schistosomiasis

    PubMed Central

    Weerakoon, Kosala G. A. D.; Gobert, Geoffrey N.; Cai, Pengfei

    2015-01-01

    SUMMARY Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis. PMID:26224883

  18. Advances in the Diagnosis of Human Schistosomiasis.

    PubMed

    Weerakoon, Kosala G A D; Gobert, Geoffrey N; Cai, Pengfei; McManus, Donald P

    2015-10-01

    Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis.

  19. 75 FR 23319 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... Transportation Resource Center Program AGENCY: Office of the Secretary of Transportation (OST), Office of Small... Funding Availability. SUMMARY: The Department of Transportation (DOT), Office of the Secretary (OST...: USDOT-OST-OSDBU-SBTRC2010-3. Catalog of Federal Domestic Assistance (CFDA) Number: 20.910 Assistance...

  20. 34 CFR 656.3 - What activities define a comprehensive or undergraduate National Resource Center?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... countries in which the modern foreign language taught is commonly used; (2) Resources for research and... other fields of study; or (3) Instruction and research on issues in world affairs that concern one or... that may contribute to the teaching and research of the Center; (e) Maintains important...

  1. 75 FR 48365 - Solicitation for a Cooperative Agreement-NIC Cost Containment Online Resource Center Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... National Institute of Corrections Solicitation for a Cooperative Agreement--NIC Cost Containment Online...: Solicitation for cooperative agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting.... The NIC Cost Containment Online Resource Center (CCORC) will be housed on the NIC Web site and...

  2. Selected References: The Middle School and Junior High. National Middle School Resource Center.

    ERIC Educational Resources Information Center

    Indiana State Dept. of Public Instruction, Indianapolis.

    This bibliography represents a revision of a previously distributed similar publication printed in the summer of 1974. It includes many items that are a part of the files of the Middle School Resource Center. These documents are starred. Materials in the bibliography are listed under the following categories: (1) books and booklets on the middle…

  3. Health Consultation & Resource Needs of Pre-Schools and Child Day Care Centers.

    ERIC Educational Resources Information Center

    Richardson, Silvana F.

    This study describes the state of health education programs and practices in child care centers in Rhode Island. The foci of the study were: (1) planned group health education activities; (2) staff ability to teach health topics; (3) availability of resources regarding health topics; (4) barriers to providing health instruction; (5) parental…

  4. 76 FR 54238 - National Center for Research Resources; Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Comparative Medicine Review...

  5. 76 FR 27337 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  6. 76 FR 369 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  7. 76 FR 24500 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  8. 75 FR 70934 - National Center For Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center For Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  9. 76 FR 55074 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  10. 75 FR 32187 - National Center for Research Resources: Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources: Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  11. 76 FR 54237 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  12. 76 FR 4121 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  13. 76 FR 78014 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  14. 76 FR 28055 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  15. 75 FR 26760 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  16. 75 FR 61768 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  17. 76 FR 54239 - National Center for Research Resources Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  18. 75 FR 57972 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  19. 75 FR 30040 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  20. 76 FR 24890 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  1. 76 FR 370 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  2. Measuring Malaysia School Resource Centers' Standards through iQ-PSS: An Online Management Information System

    ERIC Educational Resources Information Center

    Zainudin, Fadzliaton; Ismail, Kamarulzaman

    2010-01-01

    The Ministry of Education has come up with an innovative way to monitor the progress of 9,843 School Resource Centers (SRCs) using an online management information system called iQ-PSS (Quality Index of SRC). This paper aims to describe the data collection method and analyze the current state of SRCs in Malaysia and explain how the results can be…

  3. A Bibliography of Publications about the Educational Resources Information Center. (Covering the Period 1979-1984).

    ERIC Educational Resources Information Center

    Brandhorst, Ted, Ed.

    The result of a comprehensive search for documents about the Educational Resources Information Center (ERIC) published between 1979 and 1984, this bibliography lists 131 entries which approach ERIC in several different ways: documents of historical interest in the development of ERIC; "how to" items whose object is to initiate the user into the…

  4. Electronic Technology with Retarded Children: The Concept of the Training Resource Center

    ERIC Educational Resources Information Center

    Yonovitz, A.; Michaels, Robert

    1978-01-01

    To better serve the needs of severely retarded children within staff limitations, the Training Resource Center (TRC) at the Mansfield Training School (MTS) has devised certain electronic aids. TRC-developed equipment include the tangible reinforcement operant conditioning apparatus (TROCA), for audiological assessment, and a toilet training…

  5. The Role of the Learning Resources Center in Instruction. New Directions for Community Colleges, Number 71.

    ERIC Educational Resources Information Center

    Holleman, Margaret, Ed.

    1990-01-01

    With the availability of technologically advanced instructional delivery systems, and the educational reform efforts of state and federal governments, the role and importance of community college learning resource centers (LRC's) have expanded tremendously since their experimental beginnings in 1939. This volume contains the following articles…

  6. Personal Resources and Homelessness in Early Life: Predictors of Depression in Consumers of Homeless Multiservice Centers

    ERIC Educational Resources Information Center

    DeForge, Bruce R.; Belcher, John R.; O'Rourke, Michael; Lindsey, Michael A.

    2008-01-01

    This study explored the relationship between personal resources and previous adverse life events such as homelessness and depression. Participants were recruited from two church sponsored multisite social service centers in Anne Arundel County, Maryland. The interview included demographics and several standardized scales to assess history of…

  7. 76 FR 59709 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... proposals. Place: National Institutes of Health, One Democracy Plaza, 6701 Democracy Boulevard, Bethesda, MD... Review, National Center for Research Resources, NIH, 6701 Democracy Blvd, Room 1080, 1 Democracy Plaza... evaluate grant applications. Place: National Institutes of Health, One Democracy Plaza, 6701...

  8. 15 CFR 291.4 - National industry-specific pollution prevention and environmental compliance resource centers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false National industry-specific pollution... § 291.4 National industry-specific pollution prevention and environmental compliance resource centers... information on pollution prevention opportunities, regulatory compliance and technologies and techniques...

  9. 15 CFR 291.4 - National industry-specific pollution prevention and environmental compliance resource centers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false National industry-specific pollution... § 291.4 National industry-specific pollution prevention and environmental compliance resource centers... information on pollution prevention opportunities, regulatory compliance and technologies and techniques...

  10. 15 CFR 291.4 - National industry-specific pollution prevention and environmental compliance resource centers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false National industry-specific pollution... § 291.4 National industry-specific pollution prevention and environmental compliance resource centers... information on pollution prevention opportunities, regulatory compliance and technologies and techniques...

  11. An Experimental Learning Resources Center and a New Curriculum in the Social Sciences.

    ERIC Educational Resources Information Center

    Leeb, David

    At Mercer County Community College (New Jersey) an experimental learning resources center and a new curriculum in the social sciences were developed having primary objectives of: (1) keeping more minority-group students in school, (2) reducing their withdrawal rate, (3) developing assessment techniques accommodating inner-city populations, (4)…

  12. 75 FR 3741 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed...: February 17-18, 2010. Time: 8 a.m. to 5 p.m. Agenda: To provide concept review of proposed...

  13. National Institutes of Health Osteoporosis and Related Bone Diseases~National Resource Center

    MedlinePlus

    ... Language Publications (en español) | Asian-Language Publications NIH Osteoporosis and Related Bone Diseases ~ NIH National Resource Center ... Font Size | S S M M L L Bone Basics Osteoporosis Osteogenesis Imperfecta Paget’s Disease of Bone Related Topics ...

  14. Final Technical Report of the Illinois Regional Resource Center. June 1, 1974 Through November 30, 1977.

    ERIC Educational Resources Information Center

    Berjohn, Harold; Boker-Pfeiffer, Dea

    The final technical report on the Illinois Regional Resource Center (RRC) details project activities (1974 to 1977) concerning the programing and assessment of unexplained or undiagnosed handicaps. Summaries and evaluation information are presented on the following RRC efforts: state program development (including technical assistance activities);…

  15. ERIC Annual Report, 1995. Summarizing the Recent Accomplishments of the Educational Resources Information Center.

    ERIC Educational Resources Information Center

    Smarte, Lynn; Boston, Carol

    The Educational Resources Information Center (ERIC) is a federally funded, nationwide network designed to provide ready access to education information. Managed by the United States Department of Education's National Library of Education, ERIC consists of 16 clearinghouses, each devoted to a particular area of education, several adjunct…

  16. Successes and Challenges with SOS Samples at the National Center for Genetic Resources Preservation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The National Center for Genetic Resources Preservation (NCGRP) is a USDA, Agricultural Research Service facility located in Fort Collins, Colorado. NCGRP provides long term back-up services for plant, animal and microbe germplasm and is part of the National Plant Germplasm System and the National An...

  17. University of Cincinnati Alumni Association Career Resource Center Annual Report, September 1, 1979 - August 31, 1980.

    ERIC Educational Resources Information Center

    Iacono, Theresa R.

    The 1979-80 annual report of the University of Cincinnati Alumni Association's Career Resource Center (CRC) is presented. The CRC is designed to assist students, alumni, and community members in making more appropriate and meaningful choices about education beyond the high school level. Meetings are arranged between professionals and persons…

  18. 75 FR 52538 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  19. 76 FR 16797 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  20. 75 FR 54895 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  1. 76 FR 25700 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  2. 76 FR 6627 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  3. 76 FR 62814 - National Center For Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center For Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  4. 75 FR 80062 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  5. 75 FR 18216 - National Center for Research Resources; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice...

  6. 75 FR 80063 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  7. 76 FR 57748 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  8. 75 FR 52536 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  9. 76 FR 29254 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Center for Research Resources; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C....

  10. The LGBT Campus Resource Center Director: The New Profession in Student Affairs.

    ERIC Educational Resources Information Center

    Sanlo, Ronni L.

    2000-01-01

    Lesbian Gay Bisexual Transgender Campus Resource Centers (LGBT CRCs) are new service units in the field of student affairs. Study surveys LGBT CRC directors to learn about their education, salary, operating budgets, and other pertinent issues with which to identify and document a growing new profession. (Contains 14 references and two tables.)…

  11. 34 CFR 656.3 - What activities define a comprehensive or undergraduate National Resource Center?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... countries in which the modern foreign language taught is commonly used; (2) Resources for research and... other fields of study; or (3) Instruction and research on issues in world affairs that concern one or... that may contribute to the teaching and research of the Center; (e) Maintains important...

  12. Problem-Solving Research: Strategic Engagement in Community Development and the Resource Center for Raza Planning.

    ERIC Educational Resources Information Center

    Cordova, Teresa

    2002-01-01

    The Resource Center for Raza Planning (RCRP) at the University of New Mexico helps Mexican American college students use research to meet the needs of their communities. The formation and early development of RCRP are described, followed by its work on policy and planning related to community economic development. Implications for universities…

  13. Turning Russian specialized microbial culture collections into resource centers for biotechnology.

    PubMed

    Ivshina, Irena B; Kuyukina, Maria S

    2013-11-01

    Specialized nonmedical microbial culture collections contain unique bioresources that could be useful for biotechnology companies. Cooperation between collections and companies has suffered from shortcomings in infrastructure and legislation, hindering access to holdings. These challenges may be overcome by the transformation of collections into national bioresource centers and integration into international microbial resource networks.

  14. Potential of Sentinel Satellites for Schistosomiasis Monitoring

    NASA Astrophysics Data System (ADS)

    Li, C.-R.; Tang, L.-L.; Niu, H.-B.; Zhou, X.-N.; Liu, Z.-Y.; Ma, L.-L.; Zhou, Y.-S.

    2012-04-01

    Schistosomiasis is a parasitic disease that menaces human health. In terms of impact this disease is second only to malaria as the most devastating parasitic disease. Oncomelania hupensis is the unique intermediate host of Schistosoma, and hence monitoring and controlling of the number of oncomelania is key to reduce the risk of schistosomiasis transmission. Remote sensing technology can real-timely access the large-scale environmental factors related to oncomelania breeding and reproduction, such as temperature, moisture, vegetation, soil, and rainfall, and can also provide the efficient information to determine the location, area, and spread tendency of oncomelania. Many studies show that the correlation coefficient between oncomelania densities and remote sensing environmental factors depends largely on suitable and high quality remote sensing data used in retrieve environmental factors. Research achievements on retrieving environmental factors (which are related to the living, multiplying and transmission of oncomelania) by multi-source remote data are shown firstly, including: (a) Vegetation information (e.g., Modified Soil-Adjusted Vegetation Index, Normalized Difference Moisture Index, Fractional Vegetation Cover) extracted from optical remote sensing data, such as Landsat TM, HJ-1A/HSI image; (b) Surface temperature retrieval from Thermal Infrared (TIR) and passive-microwave remote sensing data; (c) Water region, soil moisture, forest height retrieval from synthetic aperture radar data, such as Envisat SAR, DLR's ESAR image. Base on which, the requirements of environmental factor accuracy for schistosomiasis monitoring will be analyzed and summarized. Our work on applying remote sensing technique to schistosomiasis monitoring is then presented. The fuzzy information theory is employed to analyze the sensitivity and feasibility relation between oncomelania densities and environmental factors. Then a mechanism model of predicting oncomelania distribution and

  15. Mental health resources for LGBT collegians: a content analysis of college counseling center Web sites.

    PubMed

    Wright, Paul J; McKinley, Christopher J

    2011-01-01

    This study content analyzed a randomly selected stratified national sample of 203 four-year United States colleges' counseling center Web sites to assess the degree to which such sites feature information and reference services for lesbian, gay, bisexual, and transgender (LGBT) collegians. Results revealed that LGBT-targeted communications were infrequent. For instance, fewer than one third of counseling center Web sites described individual counseling opportunities for LGBT students, fewer than 11% mentioned group counseling opportunities, and fewer than 6% offered a university crafted pamphlet with information about LGBT issues and resources. Findings are interpreted within the context of prior LGBT student health research.

  16. Financing Family Resource Centers: A Guide to Sources and Strategies. Starting Points: Meeting the Needs of Our Youngest Children.

    ERIC Educational Resources Information Center

    Watson, Sara; Westheimer, Miriam

    Noting that family resource centers (FRC) embody the comprehensive approach needed to respect families and meet their needs for providing their children with a healthy, nurturing beginning, and that financing issues fundamentally affect how responsive family resource centers will be to the needs of the people they serve, this guide was developed…

  17. Amarillo National Resource Center for Plutonium. Quarterly technical progress report, November 1, 1997--January 31, 1998

    SciTech Connect

    1998-03-01

    This report provides information on projects conducted by the Amarillo National Resource Center for Plutonium, a consortium of Texas A&M University, Texas Tech University, and the University of Texas. Progress is reported for four major areas: (1) plutonium information resource; (2) environmental, safety, and health; (3) communication, education, training, and community involvement; and (4) nuclear and other material studies. Environmental, safety, and health projects reported include a number of studies on high explosives. Progress reported for nuclear material studies includes storage and waste disposal investigations.

  18. Dynamics of spatial clustering of schistosomiasis in the Yangtze River Valley at the end of and following the World Bank Loan Project.

    PubMed

    Hu, Yi; Xiong, Chenglong; Zhang, Zhijie; Luo, Can; Ward, Michael; Gao, Jie; Zhang, Lijuan; Jiang, Qingwu

    2014-06-01

    The 10-year (1992-2001) World Bank Loan Project (WBLP) contributed greatly to schistosomiasis control in China. However, the re-emergence of schistosomiasis in recent years challenged the long-term progress of the WBLP strategy. In order to gain insight in the long-term progress of the WBLP, the spatial pattern of the epidemic was investigated in the Yangtze River Valley between 1999-2001 and 2007-2008. Two spatial cluster methods were jointly used to identify spatial clusters of cases. The magnitude and number of clusters varied during 1999-2001. It was found that prevalence of schistosomiasis had been greatly reduced and maintained at a low level during 2007-2008, with little change. Besides, spatial clusters most frequently occurred within 16 counties in the Dongting Lake region and within 5 counties in the Poyang Lake region. These findings precisely pointed out the prior places for future public health planning and resource allocation of schistosomiasis.

  19. Western Mineral and Environmental Resources Science Center--providing comprehensive earth science for complex societal issues

    USGS Publications Warehouse

    Frank, David G.; Wallace, Alan R.; Schneider, Jill L.

    2010-01-01

    Minerals in the environment and products manufactured from mineral materials are all around us and we use and come into contact with them every day. They impact our way of life and the health of all that lives. Minerals are critical to the Nation's economy and knowing where future mineral resources will come from is important for sustaining the Nation's economy and national security. The U.S. Geological Survey (USGS) Mineral Resources Program (MRP) provides scientific information for objective resource assessments and unbiased research results on mineral resource potential, production and consumption statistics, as well as environmental consequences of mining. The MRP conducts this research to provide information needed for land planners and decisionmakers about where mineral commodities are known and suspected in the earth's crust and about the environmental consequences of extracting those commodities. As part of the MRP scientists of the Western Mineral and Environmental Resources Science Center (WMERSC or 'Center' herein) coordinate the development of national, geologic, geochemical, geophysical, and mineral-resource databases and the migration of existing databases to standard models and formats that are available to both internal and external users. The unique expertise developed by Center scientists over many decades in response to mineral-resource-related issues is now in great demand to support applications such as public health research and remediation of environmental hazards that result from mining and mining-related activities. Western Mineral and Environmental Resources Science Center Results of WMERSC research provide timely and unbiased analyses of minerals and inorganic materials to (1) improve stewardship of public lands and resources; (2) support national and international economic and security policies; (3) sustain prosperity and improve our quality of life; and (4) protect and improve public health, safety, and environmental quality. The MRP

  20. Schistosomiasis-associated kidney disease: A review

    PubMed Central

    da Silva, Geraldo Bezerra; Duarte, Daniella Bezerra; Barros, Elvino José Guardão; Daher, Elizabeth De Francesco

    2013-01-01

    Schistosomiasis is a parasitic disease caused by organisms from the genus Schistosoma. The disease is endemic in tropical areas, where there are currently millions of people living in areas with transmission risk. Schistosomiasis-associated kidney disease is not frequently described in literature. The disease has a chronic evolution, with variable severity. Glomerulonephritis is described in 10-12% in autopsy studies. Proteinuria is reported in 20% of patients with S. mansoni infection. Schistosomal glomerulopathy generally occur in young patients, male, with hepato-splenomegaly. The glomerular lesion in schistosomiasis has an immunological nature. Antigens from the parasite seem to be related to glomerulopathy and have been found in the sera of humans and animals infected by the S. mansoni. Vesical involvement is common in the infection by S. haematobium, a parasitic disease prevalent in African countries. In the S. haematobium infection, hematuria and dysuria can be observed due to inflammation and ulceration in the bladder mucosa, generaly occuring 3 to 4 months after primary infection. Specific antiparasitic treatment is indicated to all patients infected by Schistosoma. There are 2 drugs available for treatment, praziquantel and oxamniquine. We revise the general aspects of the disease and describe the features of renal involvement in schistosomiasis.

  1. Vaccines and diagnostics for zoonotic schistosomiasis japonica.

    PubMed

    You, Hong; McManus, Donald P

    2015-02-01

    Schistosomiasis is one of the most prevalent, insidious and serious of the tropical parasitic diseases. Although the effective anthelmintic drug, praziquantel, is widely available and cheap, it does not protect against re-infection, drug-resistant schistosome may evolve and mass drug administration programmes based around praziquantel are probably unsustainable long term. Whereas protective anti-schistosome vaccines are not yet available, the zoonotic nature of Schistosoma japonicum provides a novel approach for developing a transmission-blocking veterinary vaccine in domestic animals, especially bovines, which are major reservoir hosts, being responsible for up to 90% of environmental egg contamination in China and the Philippines. However, a greater knowledge of schistosome immunology is required to understand the processes associated with anti-schistosome protective immunity and to reinforce the rationale for vaccine development against schistosomiasis japonica. Importantly as well, improved diagnostic tests, with high specificity and sensitivity, which are simple, rapid and able to diagnose light S. japonicum infections, are required to determine the extent of transmission interruption and the complete elimination of schistosomiasis following control efforts. This article discusses aspects of the host immune response in schistosomiasis, the current status of vaccine development against S. japonicum and reviews approaches for diagnosing and detecting schistosome infections in mammalian hosts.

  2. Schistosomiasis: The World's Number One Health Problem

    ERIC Educational Resources Information Center

    Mallon, Elizabeth J.

    1977-01-01

    Provides an informative discussion of the disease called schistosomiasis. The discussion covers environmental factors contributing to the disease, its symptoms, the disease organism and its vectors, and treatment of the disease. The author points out the need for water and soil pollution control in disease prone areas. (MR)

  3. New library buildings: the University of Michigan Medical Library and Learning Resource Center.

    PubMed Central

    Wulff, L Y; Calhoun, J G

    1984-01-01

    The University of Michigan opened a new medical library in July 1980. The five-story structure combines the library with a learning-resources center. Overall, the building has operated smoothly and has been well accepted. The combining of two facilities designed to support the teaching and learning objectives of the health sciences curriculum will ensure long-term cooperation between them. Images PMID:6199067

  4. Moderate and high endemicity of schistosomiasis is a predictor of the endemicity of soil-transmitted helminthiasis: a systematic review.

    PubMed

    Yajima, A; Gabrielli, A F; Montresor, A; Engels, D

    2011-02-01

    The authors conducted a systematic literature review with the following aims: to investigate how frequently soil-transmitted helminthiasis (STH) infections are endemic where schistosomiasis is present; and to assess the correlation between the risk level of schistosomiasis and that of STH. Among 155 sites on which data were collected and analyzed, schistosomiasis was present in 130, all of which were also co-endemic for STH, whereas 25 sites were endemic only for STH. Ninety percent (117 out of 130) of the areas eligible for preventive chemotherapy (PC) against schistosomiasis are also eligible for PC against STH. This fact provides managers of control programmes with the operationally important indication that use of available information on endemicity of schistosomiasis is a valid tool to predict the presence of STH in the same geographical area and to estimate the need of PC for STH. The implementation of this tool is expected to save financial and human resources and help accelerate the scale-up of PC throughout the world.

  5. Evaluation of a fungal collection as certified reference material producer and as a biological resource center.

    PubMed

    Forti, Tatiana; Souto, Aline da S S; do Nascimento, Carlos Roberto S; Nishikawa, Marilia M; Hubner, Marise T W; Sabagh, Fernanda P; Temporal, Rosane Maria; Rodrigues, Janaína M; da Silva, Manuela

    2016-01-01

    Considering the absence of standards for culture collections and more specifically for biological resource centers in the world, in addition to the absence of certified biological material in Brazil, this study aimed to evaluate a Fungal Collection from Fiocruz, as a producer of certified reference material and as Biological Resource Center (BRC). For this evaluation, a checklist based on the requirements of ABNT ISO GUIA34:2012 correlated with the ABNT NBR ISO/IEC17025:2005, was designed and applied. Complementing the implementation of the checklist, an internal audit was performed. An evaluation of this Collection as a BRC was also conducted following the requirements of the NIT-DICLA-061, the Brazilian internal standard from Inmetro, based on ABNT NBR ISO/IEC 17025:2005, ABNT ISO GUIA 34:2012 and OECD Best Practice Guidelines for BRCs. This was the first time that the NIT DICLA-061 was applied in a culture collection during an internal audit. The assessments enabled the proposal for the adequacy of this Collection to assure the implementation of the management system for their future accreditation by Inmetro as a certified reference material producer as well as its future accreditation as a Biological Resource Center according to the NIT-DICLA-061. PMID:26991280

  6. Renewable Resources: a national catalog of model projects. Volume 3. Southern Solar Energy Center Region

    SciTech Connect

    1980-07-01

    This compilation of diverse conservation and renewable energy projects across the United States was prepared through the enthusiastic participation of solar and alternate energy groups from every state and region. Compiled and edited by the Center for Renewable Resources, these projects reflect many levels of innovation and technical expertise. In many cases, a critique analysis is presented of how projects performed and of the institutional conditions associated with their success or failure. Some 2000 projects are included in this compilation; most have worked, some have not. Information about all is presented to aid learning from these experiences. The four volumes in this set are arranged in state sections by geographic region, coinciding with the four Regional Solar Energy Centers. The table of contents is organized by project category so that maximum cross-referencing may be obtained. This volume includes information on the Southern Solar Energy Center Region. (WHK)

  7. Renewable Resources: a national catalog of model projects. Volume 1. Northeast Solar Energy Center Region

    SciTech Connect

    1980-07-01

    This compilation of diverse conservation and renewable energy projects across the United States was prepared through the enthusiastic participation of solar and alternate energy groups from every state and region. Compiled and edited by the Center for Renewable Resources, these projects reflect many levels of innovation and technical expertise. In many cases, a critique analysis is presented of how projects performed and of the institutional conditions associated with their success or failure. Some 2000 projects are included in this compilation; most have worked, some have not. Information about all is presented to aid learning from these experiences. The four volumes in this set are arranged in state sections by geographic region, coinciding with the four Regional Solar Energy Centers. The table of contents is organized by project category so that maximum cross-referencing may be obtained. This volume includes information on the Northeast Solar Energy Center Region. (WHK).

  8. Demonstration house and resource center for appropriate technology. Final report, October 1, 1981-June 30, 1982

    SciTech Connect

    Not Available

    1983-04-18

    The Thoreau Center was developed as an effective demonstration for appropriate technology in Des Moines, Iowa. Efforts included: (1) physical improvements for which funding was granted: insulation of walls of the brick house from inside, and painting of walls with vapor-barrier paint; construction of a batch-type or breadbox solar hot water pre-heating system; construction of a variety of window insulation treatments for all windows; evaluation of the Center's energy use over a three year (4th year included as well) period; insulation of basement (office) space using several alternative methods; investigation of various projects, such as the originally proposed greywater system and ceiling fans; and continued emphasis on winterization and low-cost conservation methods such as caulking, weatherstripping, waterheater insulation, lowered thermostat, etc. Services of the Resource Center Library which were supported through grant funds are summarized.

  9. Perspective: Strategies for Developing Biostatistics Resources in an Academic Health Center

    PubMed Central

    Welty, Leah J.; Carter, Rickey E.; Finkelstein, Dianne; Harrell, Frank E.; Lindsell, Christopher J.; Macaluso, Maurizio; Mazumdar, Madhu; Nietert, Paul J.; Oster, Robert A.; Pollock, Brad H.; Roberson, Paula K.; Ware, James H.

    2013-01-01

    Biostatistics—the application of statistics to understanding health and biology—provides powerful tools for developing research questions, designing studies, refining measurements, analyzing data, and interpreting findings. Biostatistics plays an important role in health-related research, yet biostatistics resources are often fragmented, ad hoc, or oversubscribed within academic health centers (AHCs). Given the increasing complexity and quantity of health-related data, the emphasis on accelerating clinical and translational science, and the importance of conducting reproducible research, the need for the thoughtful development of biostatistics resources within AHCs is growing. In this article, the authors identify strategies for developing biostatistics resources in three areas: (1) recruiting and retaining biostatisticians; (2) efficiently using biostatistics resources; and (3) improving biostatistical contributions to science. AHCs should consider these three domains in building strong biostatistics resources, which they can leverage to support a broad spectrum of research. For each of the three domains, the authors describe the advantages and disadvantages of AHCs creating centralized biostatistics units rather than dispersing such resources across clinical departments or other research units. They also address the challenges biostatisticians face in contributing to research without sacrificing their individual professional growth or the trajectory of their research team. The authors ultimately recommend that AHCs create centralized biostatistics units, as this approach offers distinct advantages both to investigators who collaborate with biostatisticians as well as to the biostatisticians themselves, and it is better suited to accomplish the research and education missions of AHCs. PMID:23425984

  10. Resources

    MedlinePlus

    ... Breastfeeding - resources Bulimia - resources Burns - resources Cancer - resources Cerebral palsy - resources Celiac disease - resources Child abuse - resources Chronic fatigue syndrome - resources Chronic pain - ...

  11. [Natural environment and schistosomiasis transmission in Poyang Lake region].

    PubMed

    Lv, Shang-Biao; Lin, Dan-Dan

    2014-10-01

    Schistosomiasis is closely related to natural environmental factors. The changes of environmental factors, such as temperature, hydrology, vegetation, soil etc., all impact the scope and extent of schistosomiasis transmission. Poyang Lake is the largest freshwater lake and one of the major endemic areas with schistosomiasis in China. With global warming, the implementation of the Three Gorges Dam operation, and the Poyang Lake Ecological Economic Planning, the natural environment in Poyang Lake area has been and will continue to change, especially, the water environment and climate environment, which are more closely related to the schistosomiasis transmission. These changes, to some extent, have affected and will continue to affect the prevalence and transmission of schistosomiasis. This article reviews the relationship between the natural environment and its changes and schistosomiasis transmission in the Poyang Lake region.

  12. Evaluation of an ELISA test in past and present schistosomiasis.

    PubMed

    Azab, M E; Zakaria, S; Hussein, H M; Abdel-Hamid, M Y; el Kader, S A; Kamel, A M

    1993-08-01

    An enzyme linked immunosorbent assay (ELISA) was evaluated in relation to an indirect haemagglutination (IHA) test in schistosomiasis patients who were classified by clinical, sonographic and direct methods of diagnosis. Sensitivities of ELISA and IHA respectively proved to be 100% and 69.23% in acute simple intestinal schistosomiasis; 95.5% and 90.4% in chronic active schistosomiasis patients; 86.06% and 67.41% in patients with past history of exposure; 80% and 64.28% in patients with hepatosplenomegaly with past history of schistosomiasis, and 96% and 80% in patients with hepatic fibrosis as shown by sonar. It was apparent that ELISA is more sensitive than IHA in acute simple schistosomiasis in patients with past history of exposure, those with bilharzial hepatosplenomegaly and those with hepatic fibrosis. Both tests were nearly equally sensitive in chronic active schistosomiasis.

  13. [Natural environment and schistosomiasis transmission in Poyang Lake region].

    PubMed

    Lv, Shang-Biao; Lin, Dan-Dan

    2014-10-01

    Schistosomiasis is closely related to natural environmental factors. The changes of environmental factors, such as temperature, hydrology, vegetation, soil etc., all impact the scope and extent of schistosomiasis transmission. Poyang Lake is the largest freshwater lake and one of the major endemic areas with schistosomiasis in China. With global warming, the implementation of the Three Gorges Dam operation, and the Poyang Lake Ecological Economic Planning, the natural environment in Poyang Lake area has been and will continue to change, especially, the water environment and climate environment, which are more closely related to the schistosomiasis transmission. These changes, to some extent, have affected and will continue to affect the prevalence and transmission of schistosomiasis. This article reviews the relationship between the natural environment and its changes and schistosomiasis transmission in the Poyang Lake region. PMID:25782262

  14. Drugs for treating urinary schistosomiasis

    PubMed Central

    Kramer, Christine V; Zhang, Fan; Sinclair, David; Olliaro, Piero L

    2014-01-01

    Background Urinary schistosomiasis is caused by an intravascular infection with parasitic Schistosoma haematobium worms. The adult worms typically migrate to the venous plexus of the human bladder and excrete eggs which the infected person passes in their urine. Chronic infection can cause substantial morbidity and long-term complications as the eggs become trapped in human tissues causing inflammation and fibrosis. We summarised evidence of drugs active against the infection. This is new edition of a review first published in 1997. Objectives To evaluate the efficacy and safety of drugs for treating urinary schistosomiasis. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register, MEDLINE, CENTRAL, EMBASE and LILACS and reference lists of articles up to 23 May 2014. Selection criteria Randomized controlled trials (RCTs) of antischistosomal drugs and drug combinations compared to placebo, no intervention, or each other. Data collection and analysis Two researchers independently screened the records, extracted the data and assessed risk of bias. The primary efficacy outcomes were parasitological failure (defined as the continued presence of S. haematobium eggs in the urine at time points greater than one month after treatment), and percent reduction of egg counts from baseline. We presented dichotomous data as risk ratios (RR), and continuous data as mean difference (MD), alongside their 95% confidence intervals (CIs). Where appropriate we combined trials in meta analyses or tables. We assessed the quality of evidence using the GRADE approach. Main results We included 30 RCTs enrolling 8165 participants in this review. Twenty-four trials were conducted in children in sub-Saharan Africa, and 21 trials were over 20 years old. Many studies were assessed as being at unclear risk of bias due to inadequate descriptions of study methods. Praziquantel On average, a single 40 mg/kg dose of praziquantel reduced the proportion of people still

  15. [Road map for transmission interruption of schistosomiasis in China].

    PubMed

    Zhou, Xiao-Nong; Jiang, Qing-Wu; Guo, Jia-Gang; Lin, Dan-Dan; Zhu, Rong; Yang, Guo-Jing; Yang, Kun; Li, Shi-Zhu; Xu, Jing

    2012-02-01

    Based on the transmission status of schistosomiasis in People's Republic of China, the challenges and road map for achieving the transmission interruption of schistosomiasis by 2020 in the country was discussed, particularly focused on elimination strategy, surveillance and response approaches, and key technique needs in the three stages, e.g. pre-elimination, elimination and post-elimination stages. Recommendation of strengthening studies on transmission threshold and technological innovation at the low transmission level of schistosomiasis japonica were put forward.

  16. [Implementation of precision control to achieve the goal of schistosomiasis elimination in China].

    PubMed

    Zhou, Xiao-nong

    2016-02-01

    The integrated strategy for schistosomiasis control with focus on infectious source control, which has been implemented since 2004, accelerated the progress towards schistosomiasis control in China, and achieved transmission control of the disease across the country by the end of 2015, which achieved the overall objective of the Mid- and Long-term National Plan for Prevention and Control of Schistosomiasis (2004-2015) on schedule. Then, the goal of schistosomiasis elimination by 2025 was proposed in China in 2014. To achieve this new goal on schedule, we have to address the key issues, and implement precision control measures with more precise identification of control targets, so that we are able to completely eradicate the potential factors leading to resurgence of schistosomiasis transmission and enable the achievement of schistosomiasis elimination on schedule. Precision schistosomiasis control, a theoretical innovation of precision medicine in schistosomiasis control, will provide new insights into schistosomiasis control based on the conception of precision medicine. This paper describes the definition, interventions and the role of precision schistosomiasis control in the elimination of schistosomiasis in China, and demonstrates that sustainable improvement of professionals and integrated control capability at grass-root level is a prerequisite to the implementation of schistosomiasis control, precision schistosomiasis control is a key to the further implementation of the integrated strategy for schistosomiasis control with focus on infectious source control, and precision schistosomiasis control is a guarantee of curing schistosomiasis patients and implementing schistosomiasis control program and interventions. PMID:27356396

  17. [Implementation of precision control to achieve the goal of schistosomiasis elimination in China].

    PubMed

    Zhou, Xiao-nong

    2016-02-01

    The integrated strategy for schistosomiasis control with focus on infectious source control, which has been implemented since 2004, accelerated the progress towards schistosomiasis control in China, and achieved transmission control of the disease across the country by the end of 2015, which achieved the overall objective of the Mid- and Long-term National Plan for Prevention and Control of Schistosomiasis (2004-2015) on schedule. Then, the goal of schistosomiasis elimination by 2025 was proposed in China in 2014. To achieve this new goal on schedule, we have to address the key issues, and implement precision control measures with more precise identification of control targets, so that we are able to completely eradicate the potential factors leading to resurgence of schistosomiasis transmission and enable the achievement of schistosomiasis elimination on schedule. Precision schistosomiasis control, a theoretical innovation of precision medicine in schistosomiasis control, will provide new insights into schistosomiasis control based on the conception of precision medicine. This paper describes the definition, interventions and the role of precision schistosomiasis control in the elimination of schistosomiasis in China, and demonstrates that sustainable improvement of professionals and integrated control capability at grass-root level is a prerequisite to the implementation of schistosomiasis control, precision schistosomiasis control is a key to the further implementation of the integrated strategy for schistosomiasis control with focus on infectious source control, and precision schistosomiasis control is a guarantee of curing schistosomiasis patients and implementing schistosomiasis control program and interventions.

  18. Medical Image Resource Center--making electronic teaching files from PACS.

    PubMed

    Lim, C C Tchoyoson; Yang, Guo Liang; Nowinski, Wieslaw L; Hui, Francis

    2003-12-01

    A picture archive and communications system (PACS) is a rich source of images and data suitable for creating electronic teaching files (ETF). However, the potential for PACS to support nonclinical applications has not been fully realized: at present there is no mechanism for PACS to identify and store teaching files; neither is there a standardized method for sharing such teaching images. The Medical Image Resource Center (MIRC) is a new central image repository that defines standards for data exchange among different centers. We developed an ETF server that retrieves digital imaging and communication in medicine (DICOM) images from PACS, and enables users to create teaching files that conform to the new MIRC schema. We test-populated our ETF server with illustrative images from the clinical case load of the National Neuroscience Institute, Singapore. Together, PACS and MIRC have the potential to benefit radiology teaching and research.

  19. Medical Image Resource Center--making electronic teaching files from PACS.

    PubMed

    Lim, C C Tchoyoson; Yang, Guo Liang; Nowinski, Wieslaw L; Hui, Francis

    2003-12-01

    A picture archive and communications system (PACS) is a rich source of images and data suitable for creating electronic teaching files (ETF). However, the potential for PACS to support nonclinical applications has not been fully realized: at present there is no mechanism for PACS to identify and store teaching files; neither is there a standardized method for sharing such teaching images. The Medical Image Resource Center (MIRC) is a new central image repository that defines standards for data exchange among different centers. We developed an ETF server that retrieves digital imaging and communication in medicine (DICOM) images from PACS, and enables users to create teaching files that conform to the new MIRC schema. We test-populated our ETF server with illustrative images from the clinical case load of the National Neuroscience Institute, Singapore. Together, PACS and MIRC have the potential to benefit radiology teaching and research. PMID:14747933

  20. A qualitative evaluation of school-based family resource and youth service centers.

    PubMed

    Kalafat, J; Illback, R J

    1998-08-01

    As part of the Kentucky Education Reform Act, school-based Family Resource/Youth Service Centers were commissioned to address those poverty-related issues that attenuate children and youths' coming to school prepared to learn. The centers had flexible mandates and were to adapt their service profiles to local urban, suburban and rural communities. A variety of grounded, inductive qualitative strategies were employed in an implementation evaluation that yielded profiles or domains of program elements, and descriptions of implementation strategies and impact on participants. These program descriptors were considered accurate by program personnel, formed the basis for training new program coordinators, and have served as reliable predictors of educational outcomes for program participants, thus affirming the utility of the qualitative evaluation approaches. PMID:9772732

  1. In-situ resource utilization activities at the NASA Space Engineering Research Center

    NASA Technical Reports Server (NTRS)

    Ramohalli, Kumar

    1992-01-01

    The paper describes theoretical and experimental research activities at the NASA Space Engineering Research Center aimed at realizing significant cost savings in space missions through the use of locally available resources. The fundamental strategy involves idea generation, scientific screening, feasibility demonstrations, small-scale process plant design, extensive testing, scale-up to realistic production rates, associated controls, and 'packaging', while maintaining sufficient flexibility to respond to national needs in terms of specific applications. Aside from training, the principal activities at the Center include development of a quantitative figure-of-merit to quickly assess the overall mission impact of individual components that constantly change with advancing technologies, extensive tests on a single-cell test bed to produce oxygen from carbon dioxide, and the use of this spent stream to produce methane.

  2. The impact of schistosomiasis on human nutrition.

    PubMed

    Stephenson, L

    1993-01-01

    This article reviews studies that examine the negative effects of urinary and intestinal schistosomiasis on the following nutritional parameters in humans: urinary and faecal blood and iron loss, anaemia and haemoglobin levels, proteinuria, child growth and adult protein-energy status, physical fitness, physical activity, appetite and symptomatology. The conclusions reached are (1) that community-level treatment and control of schistosomiasis in areas where the infection, protein-energy malnutrition, and anaemia are common are to be encouraged and are likely to improve child growth, appetite, physical fitness and activity levels and to decrease anaemia and symptoms of the infection, and (2) that further studies are needed to determine how much and by what means decreases in and treatment of schistosomal infection may improve nutritional status, cognitive and school performance and attendance, and work capacity and productivity in communities with different amounts of parasitism and malnutrition.

  3. Fiscal Year 1990 program report: New Hampshire Water Resources Research Center

    SciTech Connect

    Ballestero, T.P.

    1991-08-01

    The report covers the activities of the New Hampshire Water Resource Research Center for the period July 1, 1990 through June 30, 1991. The projects include: effects of the forest land application of municipal wastewater treatment plant sludge, the analysis of how contaminants attach to lake sediments, oil spill response plans on the Piscataqua River, literature review of motor boat and personal water craft on environmental quality, performance evaluation of point-of-entry treatment units for gasoline-contaminated ground waters and automation of a portable pressure filtration system for community water supplies.

  4. Inbound Call Centers and Emotional Dissonance in the Job Demands – Resources Model

    PubMed Central

    Molino, Monica; Emanuel, Federica; Zito, Margherita; Ghislieri, Chiara; Colombo, Lara; Cortese, Claudio G.

    2016-01-01

    Background: Emotional labor, defined as the process of regulating feelings and expressions as part of the work role, is a major characteristic in call centers. In particular, interacting with customers, agents are required to show certain emotions that are considered acceptable by the organization, even though these emotions may be different from their true feelings. This kind of experience is defined as emotional dissonance and represents a feature of the job especially for call center inbound activities. Aim: The present study was aimed at investigating whether emotional dissonance mediates the relationship between job demands (workload and customer verbal aggression) and job resources (supervisor support, colleague support, and job autonomy) on the one hand, and, on the other, affective discomfort, using the job demands-resources model as a framework. The study also observed differences between two different types of inbound activities: customer assistance service (CA) and information service. Method: The study involved agents of an Italian Telecommunication Company, 352 of whom worked in the CA and 179 in the information service. The hypothesized model was tested across the two groups through multi-group structural equation modeling. Results: Analyses showed that CA agents experience greater customer verbal aggression and emotional dissonance than information service agents. Results also showed, only for the CA group, a full mediation of emotional dissonance between workload and affective discomfort, and a partial mediation of customer verbal aggression and job autonomy, and affective discomfort. Conclusion: This study’s findings contributed both to the emotional labor literature, investigating the mediational role of emotional dissonance in the job demands-resources model, and to call center literature, considering differences between two specific kinds of inbound activities. Suggestions for organizations and practitioners emerged in order to identify

  5. Health monitoring and disease prevention at the Zebrafish International Resource Center.

    PubMed

    Varga, Z M; Murray, K N

    2016-01-01

    In this chapter we review the components of the fish health program at the Zebrafish International Resource Center. We describe health-monitoring strategies to assess individual and colony health, practices to prevent the spread of pathogens within the fish colony, and a biosecurity program designed to prevent entry of new fish pathogens. While this program is designed for a facility on a recirculating water system with expectations of high volumes of import and export, many of the components can be directly applied or modified for application in facilities of different sizes and with other programmatic goals.

  6. Science center capabilities to monitor and investigate Michigan’s water resources, 2016

    USGS Publications Warehouse

    Giesen, Julia A.; Givens, Carrie E.

    2016-09-06

    Michigan faces many challenges related to water resources, including flooding, drought, water-quality degradation and impairment, varying water availability, watershed-management issues, stormwater management, aquatic-ecosystem impairment, and invasive species. Michigan’s water resources include approximately 36,000 miles of streams, over 11,000 inland lakes, 3,000 miles of shoreline along the Great Lakes (MDEQ, 2016), and groundwater aquifers throughout the State.The U.S. Geological Survey (USGS) works in cooperation with local, State, and other Federal agencies, as well as tribes and universities, to provide scientific information used to manage the water resources of Michigan. To effectively assess water resources, the USGS uses standardized methods to operate streamgages, water-quality stations, and groundwater stations. The USGS also monitors water quality in lakes and reservoirs, makes periodic measurements along rivers and streams, and maintains all monitoring data in a national, quality-assured, hydrologic database.The USGS in Michigan investigates the occurrence, distribution, quantity, movement, and chemical and biological quality of surface water and groundwater statewide. Water-resource monitoring and scientific investigations are conducted statewide by USGS hydrologists, hydrologic technicians, biologists, and microbiologists who have expertise in data collection as well as various scientific specialties. A support staff consisting of computer-operations and administrative personnel provides the USGS the functionality to move science forward. Funding for USGS activities in Michigan comes from local and State agencies, other Federal agencies, direct Federal appropriations, and through the USGS Cooperative Matching Funds, which allows the USGS to partially match funding provided by local and State partners.This fact sheet provides an overview of the USGS current (2016) capabilities to monitor and study Michigan’s vast water resources. More

  7. Northwest Climate Science Center: Integrating Regional Research, Conservation and Natural Resource Management

    NASA Astrophysics Data System (ADS)

    Mote, P.; Bisbal, G.

    2012-12-01

    The Northwest Climate Science Center (NW CSC) was established in 2010, among the first three of eight regional Climate Science Centers created by the Department of the Interior (DOI). The NW CSC is supported by an academic consortium (Oregon State University, University of Idaho, and the University of Washington), which has the capacity to generate and coordinate decision-relevant science related to climate, thus serving stakeholders across the Pacific Northwest region. The NW CSC has overlapping boundaries with three Landscape Conservation Cooperatives (LCCs): the Great Northern, the Great Basin, and the North Pacific. Collaboration between the NW CSC and these three LCCs addresses the highest priority regional climate science needs of Northwest natural and cultural resource managers. Early in 2012, the NW CSC released its first Strategic Plan for the period 2012-2015. The plan offers a practical blueprint for operation and describes five core services that the NW CSC provides to the Northwest community. These core services emphasize (a) bringing together the regional resource management and science communities to calibrate priorities and ensure efficient integration of climate science resources and tools when addressing practical issues of regional significance; (b) developing and implementing a stakeholder-driven science agenda which highlights the NW CSC's regional leadership in generating scenarios of the future environment of the NW; (c) supporting and training graduate students at the three consortium universities, including through an annual 'Climate science boot camp'; (d) providing a platform for effective climate-change-related communication among scientists, resource managers, and the general public; and (e) national leadership in data management and climate scenario development.

  8. Introducing National Center for Genome Resources (NCGR) Informatics (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema

    Crow, John [National Center for Genome Resources

    2016-07-12

    John Crow from the National Center for Genome Resources discusses his organization's informatics at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  9. Introducing National Center for Genome Resources (NCGR) Informatics (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    SciTech Connect

    Crow, John

    2012-06-01

    John Crow from the National Center for Genome Resources discusses his organization's informatics at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  10. Increasing the reach: Involving local Muslim religious teachers in a behavioral intervention to eliminate urogenital schistosomiasis in Zanzibar.

    PubMed

    Celone, Mike; Person, Bobbie; Ali, Said M; Lyimo, Jameelat H; Mohammed, Ulfat A; Khamis, Alippo N; Mohammed, Yussra S; Mohammed, Khalfan A; Rollinson, David; Knopp, Stefanie

    2016-11-01

    In Zanzibar, United Republic of Tanzania, Madrassa schools are influential institutions, where children and adults can learn about the interpretation of the Koran. We aimed to explore the involvement of Madrassa teachers for behavior change interventions in a randomized operational research trial designed to investigate the impact of multiple approaches to eliminate urogenital schistosomiasis transmission from Zanzibar. Madrassa teachers performing in the 30 communities of the behavior change study arm were trained in new interactive and participatory teaching methods by the local behavioral team and provided with schistosomiasis-teaching tools for teaching about transmission and prevention in their Madrassa. In July 2014, in a qualitative research study, we conducted 25 semi-structured interviews with Madrassa teachers to find out how they perceived their involvement in interventions against schistosomiasis. In 2014, 5926 among the 8497 registered Madrassa students in 30 communities on Unguja and Pemba islands received health education and participated in interactive behavior change exercises about schistosomiasis. Madrassa teachers reported that they valued their inclusion in the study and the opportunity to educate their students about schistosomiasis transmission, prevention, and treatment. They also perceived personal and community benefits as a result of their training and strongly supported the inclusion of additional Madrassa teachers in future intervention activities. Madrassa teachers are influential in the Zanzibari society, and hence are important change agents within our community-level behavioral intervention. They might constitute an untapped resource that can help to expand and increase acceptance of and participation in schistosomiasis and other neglected tropical disease control activities in African Muslim communities. PMID:27498244

  11. Water-based interventions for schistosomiasis control

    PubMed Central

    Evan Secor, William

    2014-01-01

    Mass drug administration with praziquantel is the mainstay of programs for the control of schistosomiasis morbidity. However, there is a growing recognition that treatment alone will not be sufficient for eventually effecting elimination and that additional measures will be required to interrupt transmission. In the absence of a safe and an effective vaccine for human schistosomiasis, the strategies to reduce infection levels will necessarily involve some interventions that affect the water-related stages of the schistosome life cycle: by reducing exposure to infectious water, by moderating availability of the intermediate snail host, or by decreasing contamination of water with egg-containing excreta. While much research on the importance of water on schistosomiasis has been performed, advances in these areas have perhaps languished with the ready availability of a cost-effective treatment. As some endemic areas near a shift to an elimination goal, a better understanding of water-based interventions that can be used alone or in concert with treatment will be needed. Reinvigoration of laboratory, field, and human behavioral aspects of this research now will ensure that the appropriate strategies are available by the time their implementation becomes necessary. PMID:25175875

  12. Ultrasonography of gallbladder abnormalities due to schistosomiasis.

    PubMed

    Richter, Joachim; Azoulay, Daniel; Dong, Yi; Holtfreter, Martha C; Akpata, Robert; Calderaro, Julien; El-Scheich, Tarik; Breuer, Matthias; Neumayr, Andreas; Hatz, Christoph; Kircheis, Gerald; Botelho, Monica C; Dietrich, Christoph F

    2016-08-01

    After malaria, schistosomiasis remains the most important tropical parasitic disease in large parts of the world. Schistosomiasis has recently re-emerged in Southern Europe. Intestinal schistosomiasis is caused by most Schistosoma (S.) spp. pathogenic to humans and leads to chronic inflammation and fibrosis of the colon as well as to liver fibrosis. Gallbladder abnormalities usually occur in patients with advanced hepatic portal fibrosis due to Schistosoma mansoni infection. Occasionally, gallbladder abnormalities have been seen also in children and occurring without associated overt liver abnormalities.The specific S. mansoni-induced gallbladder abnormalities detectable by ultrasound include typical hyperechogenic wall thickening with external gallbladder wall protuberances. The luminal wall surface is smooth. The condition is usually clinically silent although some cases of symptomatic cholecystitis have been described. The ultrasonographic Murphy response is negative. Gallbladder contractility is impaired but sludge and calculi occur rarely. Contrary to other trematodes such as liver flukes, S. mansoni does not obstruct the biliary tract. Advanced gallbladder fibrosis is unlikely to reverse after therapy.

  13. Performance evaluation of data center service localization based on virtual resource migration in software defined elastic optical network.

    PubMed

    Yang, Hui; Zhang, Jie; Ji, Yuefeng; Tan, Yuanlong; Lin, Yi; Han, Jianrui; Lee, Young

    2015-09-01

    Data center interconnection with elastic optical network is a promising scenario to meet the high burstiness and high-bandwidth requirements of data center services. In our previous work, we implemented cross stratum optimization of optical network and application stratums resources that allows to accommodate data center services. In view of this, this study extends the data center resources to user side to enhance the end-to-end quality of service. We propose a novel data center service localization (DCSL) architecture based on virtual resource migration in software defined elastic data center optical network. A migration evaluation scheme (MES) is introduced for DCSL based on the proposed architecture. The DCSL can enhance the responsiveness to the dynamic end-to-end data center demands, and effectively reduce the blocking probability to globally optimize optical network and application resources. The overall feasibility and efficiency of the proposed architecture are experimentally verified on the control plane of our OpenFlow-based enhanced SDN testbed. The performance of MES scheme under heavy traffic load scenario is also quantitatively evaluated based on DCSL architecture in terms of path blocking probability, provisioning latency and resource utilization, compared with other provisioning scheme.

  14. Human Resources Center: An Innovation in Education; General Job Functions (Unofficial); General Plan for Curriculum Organization; Early Childhood Education.

    ERIC Educational Resources Information Center

    Pontiac City School District, MI.

    The Human Resources Center in Pontiac, Michigan is an educational institution designed to help develop talents and human potential from early childhood through adulthood. The Center offers a new approach to the problems of urban communities through comprehensive planning; education is made to serve a broader role than it has in the past.…

  15. 75 FR 78997 - Centers for Disease Control and Prevention/Health Resources and Services Administration (CDC/HRSA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... HUMAN SERVICES Centers for Disease Control and Prevention Centers for Disease Control and Prevention/Health Resources and Services Administration (CDC/HRSA) Advisory Committee on HIV and STD Prevention and...-463) of October 6, 1972, that the CDC/HRSA Advisory Committee on HIV and STD Prevention and...

  16. 76 FR 22708 - Centers for Disease Control and Prevention/Health Resources and Services Administration (CDC/HRSA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... HUMAN SERVICES Centers for Disease Control and Prevention Centers for Disease Control and Prevention/Health Resources and Services Administration (CDC/HRSA) Advisory Committee on HIV and STD Prevention and... related to prevention and control of HIV/AIDS and other STDs, the support of health care services...

  17. The Contribution of Background Variables, Internal and External Resources to Life Satisfaction among Adolescents in Residential Treatment Centers

    ERIC Educational Resources Information Center

    Lipschitz-Elhawi, Racheli; Itzhaky, Haya; Michal, Hefetz

    2008-01-01

    The article deals with the contribution of background variables (gender, years of residence in a treatment center, and family status), internal resource (self-esteem), and external resources (peer, family and significant other support, sense of belonging to the community) to life satisfaction among adolescents living in residential treatment…

  18. Role of microRNAs in schistosomes and schistosomiasis.

    PubMed

    Zhu, Lihui; Liu, Jinming; Cheng, Guofeng

    2014-01-01

    Schistosomes, a class of parasitic trematode worms, cause schistosomiasis. Accumulating evidence suggests that microRNAs (miRNAs)-small, non-coding RNAs that are known to play critical regulatory roles in many organisms-may be involved in schistosome development and sexual maturation, as well as the pathogenesis of schistosomiasis. Schistosoma miRNAs, such as Bantam and miR-10, may be involved in the pathological processes of schistosomiasis, and recent studies suggest that schistosome-specific miRNAs (e.g., Bantam, miR-3479-3p) in the bloodstream of a final host could be used as biomarkers for schistosomiasis diagnosis. Furthermore, aberrant miRNAs, such as miR-223 and miR-454, can be produced by a host in response to schistosome infection, and these miRNAs may contribute to the pathogenesis of schistosomiasis-associated liver injury. Here, we summarize recent progress evaluating the relationship between schistosome miRNAs and schistosomiasis and discuss how these miRNAs can mediate the pathogenesis of schistosomiasis and be used as biomarkers for schistosomiasis diagnosis.

  19. Cryopreservation and in vitro fertilization at the Zebrafish International Resource Center

    PubMed Central

    Carmichael, Carrie; Westerfield, Monte; Varga, Zoltán M.

    2009-01-01

    In recent decades, laboratories throughout the world generated several thousand mutant, transgenic, and wild-type zebrafish lines and more lines continue to be produced. At the same time, relatively little effort has been expended to develop reliable, high-throughput, standardized, long-term cryopreservation storage methods, even though laboratories and the research community as a whole struggle to maintain the large number of lines alive. Safe and reliable methods for maintaining these valuable genetic resources are vital for future biomedical research. Cryopreservation is the most efficient method for large-scale, long-term storage of important genetic materials. It extends the time offspring can be produced from individual fish, reduces the need to maintain live populations, and can prevent catastrophic loss of irreplaceable research lines. Cryopreservation is also the most cost-effective alternative for maintaining genetic resources because it reduces costs for animal and facility maintenance, personnel, and space. In addition, it provides novel opportunities to develop new types of research using large numbers of lines. For example, several genetic strategies, such as TILLING or enhancer and gene trapping, depend on the use of cryopreservation to bypass generations of live organisms until a strain is revived for research. In this chapter, we describe and discuss the current cryopreservation method used at the Zebrafish International Resource Center. This method is derived from the initial protocol developed for zebrafish over 20 years ago that has recently been refined (1). PMID:19378097

  20. Questionnaires for rapid screening of schistosomiasis in sub-Saharan Africa.

    PubMed Central

    Lengeler, Christian; Utzinger, Jürg; Tanner, Marcel

    2002-01-01

    New initiatives are aiming to reduce the global burden of schistosomiasis, mainly through the large-scale application of chemotherapy. To target chemotherapy effectively, rapid assessment procedures are needed for identifying high-risk communities that are foci for the disease. In this review, we examine the development and validation of simple school questionnaires for screening communities for Schistosoma haematobium and S. mansoni rapidly and inexpensively. The focus is on sub-Saharan Africa, where 85% of the current schistosomiasis burden is concentrated. For more than a decade, the questionnaire approach has been validated in 10 countries, with 133 880 children interviewed in 1282 schools, and with 54 996 children examined for S. haematobium. The questionnaires were well accepted, highly reliable, and of low cost. The success of the questionnaires is explained by the fact that S. haematobium infections were easily perceived through the presence of blood in urine. Evidence from 48 258 children interviewed in 545 schools indicated that reported blood in stools and bloody diarrhoea are valuable indicators for community diagnosis of S. mansoni. However, the diagnostic performance of the questionnaires for S. mansoni was weaker than for S. haematobium, and although these results are encouraging, the questionnaires need additional validation. Recently, questionnaires were extended from community to individual diagnosis and showed considerable promise. Questionnaires are now available for promptly defining the magnitude of schistosomiasis in a large area, which will allow limited resources for morbidity control to be allocated optimally. PMID:11984610

  1. Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution

    PubMed Central

    UTZINGER, J.; RASO, G.; BROOKER, S.; DE SAVIGNY, D.; TANNER, M.; ØRNBJERG, N.; SINGER, B. H.; N’GORAN, E. K.

    2009-01-01

    SUMMARY In May 2001, the World Health Assembly (WHA) passed a resolution which urged member states to attain, by 2010, a minimum target of regularly administering anthelminthic drugs to at least 75% and up to 100% of all school-aged children at risk of morbidity. The refined global strategy for the prevention and control of schistosomiasis and soil-transmitted helminthiasis was issued in the following year and large-scale administration of anthelminthic drugs endorsed as the central feature. This strategy has subsequently been termed ‘preventive chemotherapy’. Clearly, the 2001 WHA resolution led the way for concurrently controlling multiple neglected tropical diseases. In this paper, we recall the schistosomiasis situation in Africa in mid-2003. Adhering to strategic guidelines issued by the World Health Organization, we estimate the projected annual treatment needs with praziquantel among the school-aged population and critically discuss these estimates. The important role of geospatial tools for disease risk mapping, surveillance and predictions for resource allocation is emphasised. We clarify that schistosomiasis is only one of many neglected tropical diseases and that considerable uncertainties remain regarding global burden estimates. We examine new control initiatives targeting schistosomiasis and other tropical diseases that are often neglected. The prospect and challenges of integrated control are discussed and the need for combining biomedical, educational and engineering strategies and geospatial tools for sustainable disease control are highlighted. We conclude that, for achieving integrated and sustainable control of neglected tropical diseases, a set of interventions must be tailored to a given endemic setting and fine-tuned over time in response to the changing nature and impact of control. Consequently, besides the environment, the prevailing demographic, health and social systems contexts need to be considered. PMID:19906318

  2. Update on Genomic Databases and Resources at the National Center for Biotechnology Information.

    PubMed

    Tatusova, Tatiana

    2016-01-01

    The National Center for Biotechnology Information (NCBI), as a primary public repository of genomic sequence data, collects and maintains enormous amounts of heterogeneous data. Data for genomes, genes, gene expressions, gene variation, gene families, proteins, and protein domains are integrated with the analytical, search, and retrieval resources through the NCBI website, text-based search and retrieval system, provides a fast and easy way to navigate across diverse biological databases.Comparative genome analysis tools lead to further understanding of evolution processes quickening the pace of discovery. Recent technological innovations have ignited an explosion in genome sequencing that has fundamentally changed our understanding of the biology of living organisms. This huge increase in DNA sequence data presents new challenges for the information management system and the visualization tools. New strategies have been designed to bring an order to this genome sequence shockwave and improve the usability of associated data.

  3. Update on Genomic Databases and Resources at the National Center for Biotechnology Information.

    PubMed

    Tatusova, Tatiana

    2016-01-01

    The National Center for Biotechnology Information (NCBI), as a primary public repository of genomic sequence data, collects and maintains enormous amounts of heterogeneous data. Data for genomes, genes, gene expressions, gene variation, gene families, proteins, and protein domains are integrated with the analytical, search, and retrieval resources through the NCBI website, text-based search and retrieval system, provides a fast and easy way to navigate across diverse biological databases.Comparative genome analysis tools lead to further understanding of evolution processes quickening the pace of discovery. Recent technological innovations have ignited an explosion in genome sequencing that has fundamentally changed our understanding of the biology of living organisms. This huge increase in DNA sequence data presents new challenges for the information management system and the visualization tools. New strategies have been designed to bring an order to this genome sequence shockwave and improve the usability of associated data. PMID:27115625

  4. Mars Atmospheric In Situ Resource Utilization Projects at the Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Muscatello, A. C.; Hintze, P. E.; Caraccio, A. J.; Bayliss, J. A.; Karr, L. J.; Paley, M. S.; Marone, M. J.; Gibson, T. L.; Surma, J. M.; Mansell, J. M.; Lunn, G. M.; Devor, R. W.; Berggren, M.

    2016-01-01

    The atmosphere of Mars, which is approximately 95% carbon dioxide (CO2), is a rich resource for the human exploration of the red planet, primarily by the production of rocket propellants and oxygen for life support. Three recent projects led by NASA's Kennedy Space Center have been investigating the processing of CO2. The first project successfully demonstrated the Mars Atmospheric Processing Module (APM), which freezes CO2 with cryocoolers and combines sublimated CO2 with hydrogen to make methane and water. The second project absorbs CO2 with Ionic Liquids and electrolyzes it with water to make methane and oxygen, but with limited success so far. A third project plans to recover up to 100% of the oxygen in spacecraft respiratory CO2. A combination of the Reverse Water Gas Shift reaction and the Boudouard reaction eventually fill the reactor up with carbon, stopping the process. A system to continuously remove and collect carbon is under construction.

  5. Mars Atmospheric In Situ Resource Utilization Projects at the Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Muscatello, Anthony; Hintze, Paul; Meier, Anne; Bayliss, Jon; Karr, Laurel; Paley, Steve; Marone, Matt; Gibson, Tracy; Surma, Jan; Mansell, Matt; Lunn, Griffin; Devor, Robert; Berggren, Mark

    2016-01-01

    The atmosphere of Mars, which is 96 percent carbon dioxide (CO2), is a rich resource for the human exploration of the red planet, primarily by the production of rocket propellants and oxygen for life support. Three recent projects led by NASAs Kennedy Space Center have been investigating the processing of CO2. The first project successfully demonstrated the Mars Atmospheric Processing Module (APM), which freezes CO2 with cryocoolers and combines sublimated CO2 with hydrogen to make methane and water. The second project absorbs CO2 with Ionic Liquids and electrolyzes it with water to make methane and oxygen, but with limited success so far. A third project plans to recover up to 100 of the oxygen in spacecraft respiratory CO2. A combination of the Reverse Water Gas Shift reaction and the Boudouard reaction eventually fill the reactor up with carbon, stopping the process. A system to continuously remove and collect carbon has been tested with encouraging results.

  6. Earth Resources Observation and Science (EROS) Center - Who We Are and What We Do

    USGS Publications Warehouse

    ,

    2008-01-01

    To understand our planet at local, regional, national, and global scales, people need information about Earth's land surfaces and how they are changing. Land remote sensing is the key to gathering this information. Satellites that capture detailed images of Earth's continents, islands, and coastlines are and have been EROS' primary source of remotely sensed data since the Center opened in 1973. EROS is probably best known as the USGS receiving station for Landsat satellite images. However, we acquire data and images from many other satellites, as well as from other kinds of remote sensing instruments. Roughly 1.5 terabytes* of information arrive at EROS every day to become part of the largest civilian archive of remotely sensed land data in the world. The archive represents a perfectly preserved 70-year record of Earth's land surfaces and serves as an invaluable resource for documenting how they have changed over time. *One terabyte = 1,000 gigabytes

  7. The DoD Joint Pathology Center as a Resource for Researchers.

    PubMed

    Butler, David A; Baker, Thomas P

    2015-10-01

    The Department of Defense's Joint Pathology Center (JPC) is the world's largest collection of human pathology specimens, comprising some 7.4 million accessions. The biorepository, which began during the Civil War as a collection of materials obtained from medical and surgical procedures performed by Army physicians, houses specimens and associated data obtained for diagnostic purposes. It also holds several collections of specimens from military personnel who shared a common, service-related exposure or medical condition. This article, which is excerpted and adapted from the 2012 Institute of Medicine report "Future Uses of the Department of Defense JPC Biorepository,"1 summarizes information on the repository, its past uses, and the future operational issues and challenges that the JPC faces as it develops a concept of operations that will allow it to move forward as a resource for researchers. PMID:26444897

  8. Perceived autonomy and self-care resources among senior center users.

    PubMed

    Matsui, Miho; Capezuti, Elizabeth

    2008-01-01

    Personal autonomy-the ability to make freely self-directed choices in one's life-is considered critical to an older person's quality of life. Informed by model and role-modeling nursing theory, this descriptive, correlational study examined the relationship of perceived enactment of autonomy to self-care resources, both internal (age, race, functional ability) and external (social support, living arrangements, community-based service utilization, and service satisfaction) among 120 older adults from 6 Manhattan senior centers. Participants demonstrated positive perceived autonomy. Study participants used a variety of community-based services, and their satisfaction with the services was significantly linked to autonomy. Using multiple linear regression model, the only significant predictors of perceived autonomy were race (white > nonwhite), service satisfaction, and social support. Nursing strategies such as providing information that promotes informed decision making and encouraging independence, as well as working collaboratively with members of an older persons' social network, can enhance an older persons' autonomy. PMID:18394515

  9. Informatics in radiology (infoRAD): multimedia extension of medical imaging resource center teaching files.

    PubMed

    Yang, Guo Liang; Aziz, Aamer; Narayanaswami, Banukumar; Anand, Ananthasubramaniam; Lim, C C Tchoyoson; Nowinski, Wieslaw Lucjan

    2005-01-01

    A new method has been developed for multimedia enhancement of electronic teaching files created by using the standard protocols and formats offered by the Medical Imaging Resource Center (MIRC) project of the Radiological Society of North America. The typical MIRC electronic teaching file consists of static pages only; with the new method, audio and visual content may be added to the MIRC electronic teaching file so that the entire image interpretation process can be recorded for teaching purposes. With an efficient system for encoding the audiovisual record of on-screen manipulation of radiologic images, the multimedia teaching files generated are small enough to be transmitted via the Internet with acceptable resolution. Students may respond with the addition of new audio and visual content and thereby participate in a discussion about a particular case. MIRC electronic teaching files with multimedia enhancement have the potential to augment the effectiveness of diagnostic radiology teaching.

  10. Schistosomiasis in the Democratic Republic of Congo: a literature review.

    PubMed

    Madinga, Joule; Linsuke, Sylvie; Mpabanzi, Liliane; Meurs, Lynn; Kanobana, Kirezi; Speybroeck, Niko; Lutumba, Pascal; Polman, Katja

    2015-01-01

    Schistosomiasis is a poverty-related parasitic infection, leading to chronic ill-health. For more than a century, schistosomiasis has been known to be endemic in certain provinces of the Democratic Republic of Congo (DRC). However, a clear overview on the status of the disease within the country is currently lacking, which is seriously hampering control. Here, we review the available information on schistosomiasis in DRC of the past 60 years. Findings and data gaps are discussed in the perspective of upcoming control activities.An electronic literature search via PubMed complemented by manual search of non-peer-reviewed articles was conducted up to January 2015. The search concerned all relevant records related to schistosomiasis in the DRC from January 1955 onwards. A total of 155 records were found, of which 30 met the inclusion criteria. Results were summarized by geographical region, mapped, and compared with those reported sixty years ago. The available data reported schistosomiasis in some areas located in 10 of the 11 provinces of DRC. Three species of Schistosoma were found: S. mansoni, S. haematobium and S. intercalatum. The prevalence of schistosomiasis varied greatly between regions and between villages, with high values of up to 95 % observed in some communities. The overall trend over 60 years points to the spread of schistosomiasis to formerly non-endemic areas. The prevalence of schistosomiasis has increased in rural endemic areas and decreased in urban/peri-urban endemic areas of Kinshasa. Hepatosplenomegaly, urinary tract lesions and anaemia were commonly reported in schistosomiasis endemic areas but not always associated with infection status.The present review confirms that schistosomiasis is still endemic in DRC. However, available data are scattered across time and space and studies lack methodological uniformity, hampering a reliable estimation of the current status of schistosomiasis in DRC. There is a clear need for updated prevalence data

  11. Schistosomiasis in the Democratic Republic of Congo: a literature review.

    PubMed

    Madinga, Joule; Linsuke, Sylvie; Mpabanzi, Liliane; Meurs, Lynn; Kanobana, Kirezi; Speybroeck, Niko; Lutumba, Pascal; Polman, Katja

    2015-11-19

    Schistosomiasis is a poverty-related parasitic infection, leading to chronic ill-health. For more than a century, schistosomiasis has been known to be endemic in certain provinces of the Democratic Republic of Congo (DRC). However, a clear overview on the status of the disease within the country is currently lacking, which is seriously hampering control. Here, we review the available information on schistosomiasis in DRC of the past 60 years. Findings and data gaps are discussed in the perspective of upcoming control activities.An electronic literature search via PubMed complemented by manual search of non-peer-reviewed articles was conducted up to January 2015. The search concerned all relevant records related to schistosomiasis in the DRC from January 1955 onwards. A total of 155 records were found, of which 30 met the inclusion criteria. Results were summarized by geographical region, mapped, and compared with those reported sixty years ago. The available data reported schistosomiasis in some areas located in 10 of the 11 provinces of DRC. Three species of Schistosoma were found: S. mansoni, S. haematobium and S. intercalatum. The prevalence of schistosomiasis varied greatly between regions and between villages, with high values of up to 95 % observed in some communities. The overall trend over 60 years points to the spread of schistosomiasis to formerly non-endemic areas. The prevalence of schistosomiasis has increased in rural endemic areas and decreased in urban/peri-urban endemic areas of Kinshasa. Hepatosplenomegaly, urinary tract lesions and anaemia were commonly reported in schistosomiasis endemic areas but not always associated with infection status.The present review confirms that schistosomiasis is still endemic in DRC. However, available data are scattered across time and space and studies lack methodological uniformity, hampering a reliable estimation of the current status of schistosomiasis in DRC. There is a clear need for updated prevalence data

  12. Rapid mapping of schistosomiasis and other neglected tropical diseases in the context of integrated control programmes in Africa

    PubMed Central

    BROOKER, S.; KABATEREINE, N. B.; GYAPONG, J. O.; STOTHARD, J. R.; UTZINGER, J.

    2009-01-01

    SUMMARY There is growing interest and commitment to the control of schistosomiasis and other so-called neglected tropical diseases (NTDs). Resources for control are inevitably limited, necessitating assessment methods that can rapidly and accurately identify and map high-risk communities so that interventions can be targeted in a spatially-explicit and cost-effective manner. Here, we review progress made with (i) mapping schistosomiasis across Africa using available epidemiological data and more recently, climate-based risk prediction; (ii) the development and use of morbidity questionnaires for rapid identification of high-risk communities of urinary schistosomiasis; and (iii) innovative sampling-based approaches for intestinal schistosomiasis, using the lot quality assurance sampling technique. Experiences are also presented for the rapid mapping of other NTDs, including onchocerciasis, loiasis and lymphatic filariasis. Future directions for an integrated rapid mapping approach targeting multiple NTDs simultaneously are outlined, including potential challenges in developing an integrated survey tool. The lessons from the mapping of human helminth infections may also be relevant for the rapid mapping of malaria as its control efforts are intensified. PMID:19450373

  13. Community Coordinated Modeling Center: A Powerful Resource in Space Science and Space Weather Education

    NASA Astrophysics Data System (ADS)

    Chulaki, A.; Kuznetsova, M. M.; Rastaetter, L.; MacNeice, P. J.; Shim, J. S.; Pulkkinen, A. A.; Taktakishvili, A.; Mays, M. L.; Mendoza, A. M. M.; Zheng, Y.; Mullinix, R.; Collado-Vega, Y. M.; Maddox, M. M.; Pembroke, A. D.; Wiegand, C.

    2015-12-01

    Community Coordinated Modeling Center (CCMC) is a NASA affiliated interagency partnership with the primary goal of aiding the transition of modern space science models into space weather forecasting while supporting space science research. Additionally, over the past ten years it has established itself as a global space science education resource supporting undergraduate and graduate education and research, and spreading space weather awareness worldwide. A unique combination of assets, capabilities and close ties to the scientific and educational communities enable this small group to serve as a hub for raising generations of young space scientists and engineers. CCMC resources are publicly available online, providing unprecedented global access to the largest collection of modern space science models (developed by the international research community). CCMC has revolutionized the way simulations are utilized in classrooms settings, student projects, and scientific labs and serves hundreds of educators, students and researchers every year. Another major CCMC asset is an expert space weather prototyping team primarily serving NASA's interplanetary space weather needs. Capitalizing on its unrivaled capabilities and experiences, the team provides in-depth space weather training to students and professionals worldwide, and offers an amazing opportunity for undergraduates to engage in real-time space weather monitoring, analysis, forecasting and research. In-house development of state-of-the-art space weather tools and applications provides exciting opportunities to students majoring in computer science and computer engineering fields to intern with the software engineers at the CCMC while also learning about the space weather from the NASA scientists.

  14. Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni

    PubMed Central

    Pereira, Thiago Almeida; Syn, Wing-Kin; Amâncio, Frederico Figueiredo; Cunha, Pedro Henrique Diniz; Caporali, Julia Fonseca Morais; Trindade, Guilherme Vaz de Melo; Santos, Elisângela Trindade; Souza, Márcia Maria; Andrade, Zilton Araújo; Witek, Rafal P; Secor, William Evan; Pereira, Fausto Edmundo Lima; Lambertucci, José Roberto; Diehl, Anna Mae

    2016-01-01

    Background Symptomatic acute schistosomiasis mansoni is a systemic hypersensitivity reaction against the migrating schistosomula and mature eggs after a primary infection. The mechanisms involved in the pathogenesis of acute schistosomiasis are not fully elucidated. Osteopontin has been implicated in granulomatous reactions and in acute hepatic injury. Our aims were to evaluate if osteopontin plays a role in acute Schistosoma mansoni infection in both human and experimentally infected mice and if circulating OPN levels could be a novel biomarker of this infection. Methodology/Principal Findings Serum/plasma osteopontin levels were measured by ELISA in patients with acute (n = 28), hepatointestinal (n = 26), hepatosplenic (n = 39) schistosomiasis and in uninfected controls (n = 21). Liver osteopontin was assessed by immunohistochemistry in needle biopsies of 5 patients. Sera and hepatic osteopontin were quantified in the murine model of schistosomiasis mansoni during acute (7 and 8 weeks post infection, n = 10) and chronic (30 weeks post infection, n = 8) phase. Circulating osteopontin levels are increased in patients with acute schistosomiasis (p = 0.0001). The highest levels of OPN were observed during the peak of clinical symptoms (7–11 weeks post infection), returning to baseline level once the granulomas were modulated (>12 weeks post infection). The plasma levels in acute schistosomiasis were even higher than in hepatosplenic patients. The murine model mirrored the human disease. Macrophages were the major source of OPN in human and murine acute schistosomiasis, while the ductular reaction maintains OPN production in hepatosplenic disease. Soluble egg antigens from S. mansoni induced OPN expression in primary human kupffer cells. Conclusions/Significance S. mansoni egg antigens induce the production of OPN by macrophages in the necrotic-exudative granulomas characteristic of acute schistosomiasis mansoni. Circulating OPN levels are upregulated in human and

  15. A Microfiltration Device for Urogenital Schistosomiasis Diagnostics

    PubMed Central

    Xiao, Yuan; Lu, Yi; Hsieh, Michael; Liao, Joseph; Wong, Pak Kin

    2016-01-01

    Schistosomiasis is a parasitic disease affecting over 200 million people worldwide. This study reports the design and development of a microfiltration device for isolating schistosome eggs in urine for rapid diagnostics of urogenital schistosomiasis. The design of the device comprises a linear array of microfluidic traps to immobilize and separate schistosome eggs. Sequential loading of individual eggs is achieved autonomously by flow resistance, which facilitates observation and enumeration of samples with low-abundance targets. Computational fluid dynamics modeling and experimental characterization are performed to optimize the trapping performance. By optimizing the capture strategy, the trapping efficiency could be achieved at 100% with 300 μl/min and 83% with 3000 μl/min, and the filtration procedure could be finished within 10 min. The trapped eggs can be either recovered for downstream analysis or preserved in situ for whole-mount staining. On-chip phenotyping using confocal laser fluorescence microscopy identifies the microstructure of the trapped schistosome eggs. The device provides a novel microfluidic approach for trapping, counting and on-chip fluorescence characterization of urinal Schistosoma haematobium eggs for clinical and investigative application. PMID:27124499

  16. The Menace of Schistosomiasis in Nigeria: Knowledge, Attitude, and Practices Regarding Schistosomiasis among Rural Communities in Kano State

    PubMed Central

    Dawaki, Salwa; Al-Mekhlafi, Hesham M.; Ithoi, Init; Ibrahim, Jamaiah; Abdulsalam, Awatif M.; Ahmed, Abdulhamid; Sady, Hany; Nasr, Nabil A.; Atroosh, Wahib M.

    2015-01-01

    Background Schistosomiasis is one of the most common neglected tropical diseases, especially in the developing countries in Africa, Asia and South America, with Nigeria having the greatest number of cases of schistosomiasis worldwide. This community-based study aims to evaluate the knowledge, attitude and practices (KAP) regarding schistosomiasis among rural Hausa communities in Kano State, Nigeria. Methods A cross-sectional study was carried out among 551 participants from Hausa communities in five local government areas in Kano State, North Central Nigeria. Demographic, socioeconomic and environmental information as well as KAP data were collected using a pre-tested questionnaire. Moreover, faecal and urine samples were collected and examined for the presence of Schistosoma mansoni and S. haematobium eggs respectively. Results The overall prevalence of schistosomiasis was 17.8%, with 8.9% and 8.3% infected with S. mansoni and S. haematobium respectively, and 0.5% had co-infection of both species. Moreover, 74.5% of the participants had prior knowledge about schistosomiasis with 67.0% of them how it is transmitted and 63.8% having no idea about the preventive measures. Three-quarters of the respondents considered schistosomiasis a serious disease while their practices to prevent infections were still inadequate, with only 34.7% of them seeking treatment from clinics/hospitals. Significant associations between the KAP and age, gender, education and employment status were reported. Multiple logistic regression analysis revealed that age, gender, history of infection and educational level of the respondents were the most important factors significantly associated with the KAP on schistosomiasis among this population. Conclusions Schistosomiasis is still prevalent among Hausa communities in Nigeria and participants’ knowledge about the disease was poor. Mass drug administration, community mobilization and health education regarding the cause, transmission and

  17. The International Center for Integrated Water Resources Management (ICIWaRM): The United States' Contribution to UNESCO IHP's Global Network of Water Centers

    NASA Astrophysics Data System (ADS)

    Logan, W. S.

    2015-12-01

    The concept of a "category 2 center"—i.e., one that is closely affiliated with UNESCO, but not legally part of UNESCO—dates back many decades. However, only in the last decade has the concept been fully developed. Within UNESCO, the International Hydrological Programme (IHP) has led the way in creating a network of regional and global water-related centers.ICIWaRM—the International Center for Integrated Water Resources Management—is one member of this network. Approved by UNESCO's General Conference, the center has been operating since 2009. It was designed to fill a niche in the system for a center that was backed by an institution with on-the-ground water management experience, but that also had strong connections to academia, NGOs and other governmental agencies. Thus, ICIWaRM is hosted by the US Army Corps of Engineers' Institute for Water Resources (IWR), but established with an internal network of partner institutions. Three main factors have contributed to any success that ICIWaRM has achieved in its global work: A focus on practical science and technology which can be readily transferred. This includes the Corps' own methodologies and models for planning and water management, and those of our university and government partners. Collaboration with other UNESCO Centers on joint applied research, capacity-building and training. A network of centers needs to function as a network, and ICIWaRM has worked together with UNESCO-affiliated centers in Chile, Brazil, Paraguay, the Dominican Republic, Japan, China, and elsewhere. Partnering with and supporting existing UNESCO-IHP programs. ICIWaRM serves as the Global Technical Secretariat for IHP's Global Network on Water and Development Information in Arid Lands (G-WADI). In addition to directly supporting IHP, work through G-WADI helps the center to frame, prioritize and integrate its activities. With the recent release of the United Nation's 2030 Agenda for Sustainable Development, it is clear that

  18. ESL Resource Center. An Annotated Bibliography of Selected Resources for Vocational Preparation for Limited English Proficient Students.

    ERIC Educational Resources Information Center

    Binder, Andrea, Comp.; And Others

    This annotated bibliography contains publication data and information on the content and availability of 58 resource materials that are recommended for use in vocational preparation programs for individuals with limited English proficiency. Descriptions of the resource materials are organized into sections on the following topics: English as a…

  19. Heuristic Evaluation of Online COPD Respiratory Therapy and Education Video Resource Center

    PubMed Central

    Chaney, Beth; Chaney, Don

    2014-01-01

    Abstract Purpose: Because of limited accessibility to pulmonary rehabilitation programs, patients with chronic obstructive pulmonary disease (COPD) are infrequently provided with patient education resources. To help educate patients with COPD on how to live a better life with diminished breathing capacity, we developed a novel social media resource center containing COPD respiratory therapy and education videos called “COPDFlix.” Methodology: A heuristic evaluation of COPDFlix was conducted as part of a larger study to determine whether the prototype was successful in adhering to formal Web site usability guidelines for older adults. A purposive sample of three experts, with expertise in Web design and health communications technology, was recruited (a) to identify usability violations and (b) to propose solutions to improve the functionality of the COPDFlix prototype. Each expert evaluated 18 heuristics in four categories of task-based criteria (i.e., interaction and navigation, information architecture, presentation design, and information design). Seventy-six subcriteria across these four categories were assessed. Quantitative ratings and qualitative comments from each expert were compiled into a single master list, noting the violated heuristic and type/location of problem(s). Results: Sixty-one usability violations were identified across the 18 heuristics. Evaluators rated the majority of heuristic subcriteria as either a “minor hindrance” (n=32) or “no problem” (n=132). Moreover, only 2 of the 18 heuristic categories were noted as “major” violations, with mean severity scores of ≥3. Conclusions: Mixed-methods data analysis helped the multidisciplinary research team to categorize and prioritize usability problems and solutions, leading to 26 discrete design modifications within the COPDFlix prototype. PMID:24650318

  20. Potential schistosomiasis foci in China: a prospective study for schistosomiasis surveillance and response.

    PubMed

    Qian, Ying-Jun; Li, Shi-Zhu; Xu, Jing; Yang, Kun; Huang, Yi-Xin; Cao, Zhi-Guo; Miu, Feng; Dang, Hui; Zhang, Li-Juan; Zhang, Li; Wang, Qiang; Bergquist, Robert; Zhou, Xiao-Nong

    2015-01-01

    Schistosomiasis japonica was endemic in 12 provinces (including municipalities and autonomous regions) in the People's Republic of China (PR China). Despite the tremendous decrease of schistosomiasis incidence after almost 60 years of control, the distribution of snail-breeding sites has not been reduced significantly. In order to verify current transmission risks and identify the potential establishment of new foci of schistosomiasis driven by environmental changes, we conducted surveillance in selected risk areas of three provinces: Jiangsu, Anhui and Shandong from 2008 to 2010 in addition to routine snail surveillance. We investigated populations and possible reservoirs in sentinel sites and report that the total number of new acute cases did not diminish further in spite of ongoing control activities. In Anhui Province the local count compared to the national count was 43% (19/44) in 2008, 33% (25/75) in 2009 and 40% (17/42) in 2010. In all, 31.58 km(2) areas of snail breeding sites were newly detected nationwide through the year 2008-2010, of which the proportion of Anhui was 42% (5.03/11.98) in 2008, 95% (8.39/8.79) in 2009 and 79% (8.52/10.81) in 2010. Sentinel surveillance showed eight, nine and five confirmed cases of acute schistosomiasis in mobile populations (fishermen, migrant workers) in 2008, 2009 and 2010, respectively. All these cases were detected in Chaohu County, which must therefore be deemed an area at risk. We conclude that continuous surveillance with an emphasis on snails must be enhanced in potential risk areas in PR China.

  1. Uptake of Mass Drug Administration Programme for Schistosomiasis Control in Koome Islands, Central Uganda

    PubMed Central

    Tuhebwe, Doreen; Bagonza, James; Kiracho, Elizabeth Ekirapa; Yeka, Adoke; Elliott, Alison M.; Nuwaha, Fred

    2015-01-01

    Introduction Schistosomiasis is one of the neglected tropical diseases targeted for elimination in Uganda through the Mass Drug Administration (MDA) programme. Praziquantel has been distributed using community resource persons in fixed sites and house-to-house visits; however the uptake is still below target coverage. In 2011/2012 MDA exercise, uptake stood at 50% yet WHO target coverage is 75% at community level. We assessed the uptake of MDA and the associated factors in Koome Islands, Central Uganda. Methods In March 2013, we conducted a mixed methods cross sectional study in 15 randomly selected villages. We interviewed a total of 615 respondents aged 18 years and above using semi structured questionnaires and five key informants were also purposively selected. Univariate and multivariate analysis was done. MDA uptake was defined as self reported swallowing of praziquantel during the last (2012) MDA campaign. We conducted key informant interviews with Ministry of Health, district health personnel and community health workers. Results Self reported uptake of praziquantel was 44.7% (275/615), 95% confidence interval (CI) 40.8–48.7%. Of the 275 community members who said they had swallowed praziquantel, 142 (51.6%) reported that they had developed side effects. Uptake of MDA was more likely if the respondent was knowledgeable about schistosomiasis transmission and prevention (adjusted odds ratio [AOR] 1.85, 95% CI 1.22–2.81) and reported to have received health education from the health personnel (AOR 5.95, 95% CI 3.67–9.65). Service delivery challenges such as drug shortages and community health worker attrition also influenced MDA in Koome Islands. Conclusions Uptake of MDA for schistosomiasis control in Koome was sub optimal. Lack of knowledge about schistosomiasis transmission and prevention, inadequate health education and drug shortages are some of the major factors associated with low uptake. These could be addressed through routine health education

  2. Lessons Learned from Creating the Public Earthquake Resource Center at CERI

    NASA Astrophysics Data System (ADS)

    Patterson, G. L.; Michelle, D.; Johnston, A.

    2004-12-01

    The Center for Earthquake Research and Information (CERI) at the University of Memphis opened the Public Earthquake Resource Center (PERC) in May 2004. The PERC is an interactive display area that was designed to increase awareness of seismology, Earth Science, earthquake hazards, and earthquake engineering among the general public and K-12 teachers and students. Funding for the PERC is provided by the US Geological Survey, The NSF-funded Mid America Earthquake Center, and the University of Memphis, with input from the Incorporated Research Institutions for Seismology. Additional space at the facility houses local offices of the US Geological Survey. PERC exhibits are housed in a remodeled residential structure at CERI that was donated by the University of Memphis and the State of Tennessee. Exhibits were designed and built by CERI and US Geological Survey staff and faculty with the help of experienced museum display subcontractors. The 600 square foot display area interactively introduces the basic concepts of seismology, real-time seismic information, seismic network operations, paleoseismology, building response, and historical earthquakes. Display components include three 22" flat screen monitors, a touch sensitive monitor, 3 helicorder elements, oscilloscope, AS-1 seismometer, life-sized liquefaction trench, liquefaction shake table, and building response shake table. All displays include custom graphics, text, and handouts. The PERC website at www.ceri.memphis.edu/perc also provides useful information such as tour scheduling, ask a geologist, links to other institutions, and will soon include a virtual tour of the facility. Special consideration was given to address State science standards for teaching and learning in the design of the displays and handouts. We feel this consideration is pivotal to the success of any grass roots Earth Science education and outreach program and represents a valuable lesson that has been learned at CERI over the last several

  3. A case of female urogenital schistosomiasis presenting as viral warts.

    PubMed

    Samuel, M I; Taylor, C

    2015-07-01

    Schistosomiasis is uncommon in the UK but is found in migrant populations and in those who travel to areas of endemic schistosomiasis. Apparent clinical symptoms may occur long after the patient has left an endemic area. Female urogenital schistosomiasis (arising from infection by Schistosoma haematobium, endemic in Africa and the Middle East) may show a variety of lesions in the female genital tract, some of which may be misdiagnosed as viral warts. One such case is presented here. A young woman presented with lesions on the labia minora suspected to be viral warts which had not responded to treatment with cryotherapy. Biopsy of the lesions and spun urine microscopy revealed S. haematobium eggs. The lesions resolved following treatment with praziquantel. Clinicians should also be aware of the high rate of urogenital schistosomiasis in women from endemic areas, which is associated with urogynaecological morbidity and also increases the risk of acquisition of HIV infection.

  4. Predation of schistosomiasis vector snails by ostracoda (crustacea)

    USGS Publications Warehouse

    Sohn, I.G.; Kornicker, L.S.

    1972-01-01

    An ostracod species of Cypretta is an effective predator in laboratory experiments on 1- to 3-day-old Biomphalaria glabrata, a vector snail of the blood fluke that causes the tropical and subtropical disease schistosomiasis.

  5. Microbial cultivation and the role of microbial resource centers in the omics era.

    PubMed

    Prakash, Om; Shouche, Yogesh; Jangid, Kamlesh; Kostka, Joel E

    2013-01-01

    Despite tremendous advances in microbial ecology over the past two decades, traditional cultivation methods have failed to grow ecologically more relevant microorganisms in the laboratory, leading to a predominance of weed-like species in the world's culture collections. In this review, we highlight the gap between culture-based and culture-independent methods of microbial diversity analysis, especially in investigations of slow growers, oligotrophs, and fastidious and recalcitrant microorganisms. Furthermore, we emphasize the importance of microbial cultivation and the acquisition of the cultivation-based phenotypic data for the testing of hypotheses arising from genomics and proteomics approaches. Technical difficulties in cultivating novel microorganisms and how modern approaches have helped to overcome these limitations are highlighted. After cultivation, adequate preservation without changes in genotypic and phenotypic features of these microorganisms is necessary for future research and training. Hence, the contribution of microbial resource centers in the handling, preservation, and distribution of this novel diversity is discussed. Finally, we explore the concept of microbial patenting and requisite guidelines of the "Budapest Treaty" for establishment of an International Depositary Authority.

  6. The Illinois Regional Resource Center Diagnostic Teaching Model: A Systems Approach to Assessment and Programming for Children with Unexplained Handicaps.

    ERIC Educational Resources Information Center

    Preston-Hinsdale, Kirsten; And Others

    Presented is the Illinois Regional Resource Center's Manual for Diagnostic Teachers which is designed to provide a model for assessment, individualized educational planning, optimal placement, and short and long range follow-up of children (3-21 years old) with unexplained learning problems. Section 1 provides an introduction to the…

  7. Selecting Diverse Resources of Native American Perspective for the Curriculum Center: Children's Literature, Leveled Readers, and Social Studies Curriculum

    ERIC Educational Resources Information Center

    Meyer, Nadean

    2011-01-01

    Biased and inaccurate information about Native Americans continue in children's resources and remain in many of today's curriculum centers. While Native American students remain a minority in schools, accurate information is vital for understanding contemporary society and our history by both Native and non-Native students. Many states including…

  8. The Regional Resource Center (RRC) Network Accountability Report Executive Summary: The First RRC Network Performance Measurement Look

    ERIC Educational Resources Information Center

    Federal Resource Center for Special Education, 2005

    2005-01-01

    The Regional Resource Center (RRC) program mission is to strengthen the capacity of state systems of education and early intervention to improve results for infants, toddlers, children and youth with disabilities and their families. It is one of the longest and most successful technical assistance projects of the Office of Special Education…

  9. A Study of the Continuing Education Interests of Illinois Community College Library and Learning Resource Center Personnel. Summary Report.

    ERIC Educational Resources Information Center

    Means, Robert P.

    The survey of the professional continuing education needs and interests of Illinois public and private community college library/learning resource center personnel which is summarized was conducted by the Illinois Library Association in conjunction with the development of better continuing education programs for its membership. Major findings…

  10. Homing in on Our Customers: How the Praxair Information Resource Center Reevaluated and Implemented a New Marketing Strategy.

    ERIC Educational Resources Information Center

    Megaridis, Crystal S.

    Work request statistics have been tracked at the Praxair Information Resource Center (IRC) for nearly a decade. After a gradual and steady increase of work requests over the years, the work requested of the IRC reached a plateau in 1999 that lasted approximately 1 year. Work request statistics during the winter of 2000, however, indicated a shift…

  11. "Anchors Away!" Implementing Program-Wide Positive Behavior Supports at the Visiting Nurses Association Child Care and Family Resource Center

    ERIC Educational Resources Information Center

    Muscott, Howard Steven; Pomerleau, Tina; Dupuis, Sherry

    2009-01-01

    Early childhood programs are growing increasingly concerned about the number of preschoolers exhibiting challenging behavior. This case study describes how educators at the Visiting Nurses Association Child Care and Family Resource Center program addressed this concern by implementing the systems, data, and practices of Program-Wide Positive…

  12. Prioritization of Malus accessions for collection cryopreservation at the USDA-ARS National Center for Genetic Resources Preservation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The USDA-ARS National Plant Germplasm System maintains a grafted collection of apple accessions representing 49 taxa in Geneva, NY. Dormant buds of many of these accessions have been routinely cryopreserved at the USDA-ARS National Center for Genetic Resources Preservation (NCGRP) in Fort Collins, C...

  13. The Amarillo National Resource Center for Plutonium. Quarterly progress detailed report, 1 November 1996--31 January 1997

    SciTech Connect

    1997-03-01

    Progress for this quarter is given for each of the following Center programs: (1) plutonium information resource; (2) advisory function (DOE and state support); (3) environmental, public health and safety; (3) communication, education, and training; and (4) nuclear and other material studies. Both summaries of the activities and detailed reports are included.

  14. An On-Line Information Management System for Resources for Staff Development for the Professional Development Center Network.

    ERIC Educational Resources Information Center

    Monroe, Eula Ewing

    The Professional Development Center Network (PDC), a consortium of twenty public school districts, parochial schools, and Western Kentucky University, seeks to identify and secure resources to assist in the design and delivery of activities appropriate to the educational development of individual staff members through the online Information…

  15. Macrophages are required for host survival in experimental urogenital schistosomiasis

    PubMed Central

    Fu, Chi-Ling; Odegaard, Justin I.; Hsieh, Michael H.

    2015-01-01

    Urogenital schistosomiasis, Schistosoma haematobium worm infection, afflicts millions of people with egg-triggered, fibrotic bladder granulomata. Despite the significant global impact of urogenital schistosomiasis, the mechanisms of bladder granulomogenesis and fibrosis are ill defined due to the prior lack of tractable animal models. We combined a mouse model of urogenital schistosomiasis with macrophage-depleting liposomal clodronate (LC) to define how macrophages mediate bladder granulomogenesis and fibrosis. Mice were injected with eggs purified from infected hamsters or vehicle prepared from uninfected hamster tissues (xenoantigen and injection trauma control). Empty liposomes were controls for LC: 1) LC treatment resulted in fewer bladder egg granuloma-infiltrating macrophages, eosinophils, and T and B cells, lower bladder and serum levels of eotaxin, and higher bladder concentrations of IL-1α and chemokines (in a time-dependent fashion), confirming that macrophages orchestrate leukocyte infiltration of the egg-exposed bladder; 2) macrophage-depleted mice exhibited greater weight loss and bladder hemorrhage postegg injection; 3) early LC treatment postegg injection resulted in profound decreases in bladder fibrosis, suggesting differing roles for macrophages in fibrosis over time; and 4) LC treatment also led to egg dose-dependent mortality, indicating that macrophages prevent death from urogenital schistosomiasis. Thus, macrophages are a potential therapeutic target for preventing or treating the bladder sequelae of urogenital schistosomiasis.—Fu, C.-L., Odegaard, J. I., Hsieh, M. H. Macrophages are required for host survival in experimental urogenital schistosomiasis. PMID:25351984

  16. Enhancing collaboration between China and African countries for schistosomiasis control.

    PubMed

    Xu, Jing; Yu, Qing; Tchuenté, Louis-Albert Tchuem; Bergquist, Robert; Sacko, Moussa; Utzinger, Jürg; Lin, Dan-Dan; Yang, Kun; Zhang, Li-Juan; Wang, Qiang; Li, Shi-Zhu; Guo, Jia-Gang; Zhou, Xiao-Nong

    2016-03-01

    Schistosomiasis remains an important public health issue, with a large number of cases reported across sub-Saharan Africa, and parts of Asia and Latin America. China was once highly endemic, but has made substantial progress and is moving towards elimination of schistosomiasis. Meanwhile, despite long-term, repeated, school-based chemotherapy in many African countries, more than 90% of all schistosomiasis cases are concentrated in Africa, and hence, this continent constitutes the key challenge for schistosomiasis control. Opportunities and issues for international collaboration in the fight against schistosomiasis are outlined with a focus on China's experiences, including the role of public health authorities and intersectoral collaboration, use of new and effective snail control approaches and diagnostic tools adapted to the specific stage of control, as well as the strengthening of risk mapping and surveillance-response mechanisms. Training courses targeting African governmental officials and professionals, coupled with field visits of African scientists and control programme managers to China, and vice versa, are considered important for improved schistosomiasis control and elimination. The crucial question remains whether the Chinese experience can be translated and applied in African countries to improve the effectiveness of health interventions and scale-up.

  17. Spinal Cord Schistosomiasis: Two Different Outcomes

    PubMed Central

    Alsomaili, Mohammed; Abulaban, Ahmad A.

    2016-01-01

    Spinal cord schistosomiasis is difficult to diagnose in nonendemic areas. We report the clinical profile of 2 young Saudi males who presented with myelopathy. The first patient arrived at our hospital relatively late, i.e. 3 months following the presentation of initial symptoms, and had received both pulse steroid therapy and a plasma exchange. Praziquantel was administered late and the patient did not recover. The second case presented early, i.e. within around 8 weeks of initial symptoms. This patient received praziquantel without any kind of steroid and had a complete recovery. We concluded that prompt recognition and early treatment with praziquantel is crucial for a better outcome. The role of steroids in these cases still needs to be proven. PMID:27293404

  18. PARASITES AND POVERTY: THE CASE OF SCHISTOSOMIASIS

    PubMed Central

    King, Charles H.

    2009-01-01

    Simultaneous and sequential transmission of multiple parasites, and their resultant overlapping chronic infections, are facts of life in many underdeveloped rural areas. These represent significant but often poorly-measured health and economic burdens for affected populations. For example, the chronic inflammatory process associated with long-term schistosomiasis contributes to anaemia and undernutrition, which, in turn, can lead to growth stunting, poor school performance, poor work productivity, and continued poverty. To date, most national and international programs aimed at parasite control have not considered the varied economic and ecological factors underlying multi-parasite transmission, but some are beginning to provide a coordinated approach to control. In addition, interest is emerging in new studies for the re-evaluation and recalibration of the health burden of helminthic parasite infection. Their results should highlight the strong potential of integrated parasite control in efforts for poverty reduction. PMID:19962954

  19. [Appropriate technology: a driver to eliminate schistosomiasis in China. In- sights gained from the First Forum on Schistosomiasis Control in China].

    PubMed

    Hong, Qing-biao; Wen, Li-yong; Zhong, Bo; Yang, Hai-tao; Li, Shi-zhu; Liang, You-sheng; Zhang, Shi-qing; Ren, Guang-hui; Lin, Dan-dan; Sun, Le-ping; Zhou, Xiao-nong

    2015-10-01

    This paper described the First Forum on Schistosomiasis Control in China. With "Appropriate technology is essential to schistosomiasis prevention and control" as the topic, the forum shared the main interventions and experiences for schistosomiasis control and elimination, exhibited the recent achievements gained from the development of appropriate technology for schistosomiasis control, showed the technical support of appropriate technology for schistosomiasis elimination, and proposed the priority for the future research and development of appropriate technology for schistosomiasis control and elimination in China. It is considered that the forum builds a bridge for communicating information between the administrative sectors and specialized prevention and control institutions, between research institutions and manufactures, and between experts/professors and grassroots professional staff, and provides a platform to communicate the national schistosomiasis control knowledge of China.

  20. The retention of health human resources in primary healthcare centers in Lebanon: a national survey

    PubMed Central

    2012-01-01

    Background Critical shortages of health human resources (HHR), associated with high turnover rates, have been a concern in many countries around the globe. Of particular interest is the effect of such a trend on the primary healthcare (PHC) sector; considered a cornerstone in any effective healthcare system. This study is a rare attempt to investigate PHC HHR work characteristics, level of burnout and likelihood to quit as well as the factors significantly associated with staff retention at PHC centers in Lebanon. Methods A cross-sectional design was utilized to survey all health providers at 81 PHC centers dispersed in all districts of Lebanon. The questionnaire consisted of four sections: socio-demographic/ professional background, organizational/institutional characteristics, likelihood to quit and level of professional burnout (using the Maslach-Burnout Inventory). A total of 755 providers completed the questionnaire (60.5% response rate). Bivariate analyses and multinomial logistic regression were used to determine factors associated with likelihood to quit. Results Two out of five respondents indicated likelihood to quit their jobs within the next 1–3 years and an additional 13.4% were not sure about quitting. The top three reasons behind likelihood to quit were poor salary (54.4%), better job opportunities outside the country (35.1%) and lack of professional development (33.7%). A U-shaped relationship was observed between age and likelihood to quit. Regression analysis revealed that high levels of burnout, lower level of education and low tenure were all associated with increased likelihood to quit. Conclusions The study findings reflect an unstable workforce and are not conducive to supporting an expanded role for PHC in the Lebanese healthcare system. While strategies aiming at improving staff retention would be important to develop and implement for all PHC HHR; targeted retention initiatives should focus on the young-new recruits and allied health

  1. The Counseling Center: An Undervalued Resource in Recruitment, Retention, and Risk Management

    ERIC Educational Resources Information Center

    Bishop, John B.

    2010-01-01

    A primary responsibility for directors of college and university counseling centers is to explain to various audiences the multiple ways such units are of value to their institutions. This article reviews the history of how counseling center directors have been encouraged to develop and describe the work of their centers. Often overlooked are the…

  2. Organizing a Successful Family Center in Your School. A Resource Guide. Revised 2005

    ERIC Educational Resources Information Center

    Wisconsin Department of Public Instruction, 2005

    2005-01-01

    This booklet was developed to help school staff members, parents, and community leaders understand how family centers can promote family participation and strengthen their schools. It also serves as a guide to establishing family centers. The term, family center, is used throughout this booklet, although many schools prefer to call their center…

  3. Massachusetts Water Resource Research Center: Annual program report, 1988 (FY 1987)

    SciTech Connect

    Not Available

    1988-12-01

    The Massachusetts Water Resources Research Center program for 1987-88 (Federal Fiscal Year FY87) focused on several research areas of high priority for the state and New England region: acid deposition impacts, the minimization of nitrate contamination of groundwater from on-site wastewater treatment, the pricing of drinking water to meet future infrastructure needs, and the proposed diversion of water from a ''Wild and Scenic'' river. Three WRIP Projects were begun in FY87. One evaluates cloud and fog acidity in central Massachusetts, another evaluates the use of peat in rural sewage disposal systems to minimize nitrate contamination of groundwater, and the third will determine the true cost of water so that utilities may appropriately plan for new sources or infrastructure renovation. The Cooperative Aquatic Research Program (CARP) funded five projects; four were acid deposition-related projects. Phase III of the Acid Rain Monitoring Project continued monitoring 500 randomly selected and 300 special interest surface waters quarterly and will continue into its fourth year of the ten year program. Investigation of the role of acid deposition in enhancing microorganisms in lake sediment that may play a role in methylating heavy metals such as mercury continued. Similarly, the study of mechanisms of control of aluminum mobility in watersheds subjected to acid deposition and the study of the impact of acid deposition on salamander communities were continued. Research on the role of sulfate reduction in lakes as a natural mechanism for neutralizing acidity funded in its first year by WRIP, has been continued. All but the Acid Rain Monitoring Project are to be completed in 1988.

  4. [Application of high resolution remote sensing technology in research of schistosomiasis surveillance].

    PubMed

    Xue, Jing-bo; Zhang, Li-juan; Wang, Qiang; Lu, Yan-xin; Li, Shi-zhu

    2015-10-01

    Schistosomiasis is closely related to environmental factors, the changes of environmental factors, such as vegetation, temperature, hydrology and soil, could impact the transmission of the disease. The environmental factors associated with schistosomiasis could be extracted by remote sensing technology quickly and precisely, and be applied to monitor the schistosomiasis transmission. The studies on high resolution remote sensing technology applied in the research of schistosomiasis are reviewed in this paper.

  5. Schistosomiasis and the risk of bladder cancer in Alexandria, Egypt.

    PubMed

    Bedwani, R; Renganathan, E; El Kwhsky, F; Braga, C; Abu Seif, H H; Abul Azm, T; Zaki, A; Franceschi, S; Boffetta, P; La Vecchia, C

    1998-04-01

    The relationship between history of schistosomiasis and bladder cancer risk was investigated using data from a case-control study conducted between January 1994 and July 1996 in Alexandria, Egypt. Cases were 190 subjects with incident, histologically confirmed invasive cancer of the bladder, and controls were 187 subjects admitted to hospital for acute, non-neoplastic, non-urinary tract conditions. Eighty-six cases (45%) vs 69 controls (37%) reported a history of urinary schistosomiasis. The corresponding multivariate odds ratio (OR) of bladder cancer -- after allowance for age, sex, education, smoking, other urinary infections and high-risk occupations -- was 1.72 (95% confidence interval (CI) 1.0-2.9). The ORs were 0.22 (95% CI 0.1-0.4) for intestinal schistosomiasis and 0.32 (95% CI 0.1-1.9) for schistosomiasis of other types. The OR for urinary schistosomiasis was higher in subjects who were younger at first diagnosis (OR of 3.3 for <15 years) and in those with a long time since first diagnosis (OR of 3.0 for > or = 35 years). The ORs were 15.8 for male ever-smokers with a history of urinary schistosomiasis, compared with never-smokers without such a history, and 3.2 for men ever-infected with urinary Schistosoma haematobium and ever-employed in high-risk occupations, compared with those never-infected and with no high-risk occupational history. This study confirms that clinical history of urinary schistosomiasis is significantly, but modestly, associated with increased bladder cancer risk, explaining some 16% of bladder cancer cases in this Egyptian population.

  6. COMMUNITY CO-DESIGNED SCHISTOSOMIASIS CONTROL INTERVENTIONS FOR SCHOOL-AGED CHILDREN IN ZANZIBAR.

    PubMed

    Person, B; Knopp, S; Ali, S M; A'kadir, F M; Khamis, A N; Ali, J N; Lymo, J H; Mohammed, K A; Rollinson, D

    2016-09-01

    Top-down biomedical interventions to control schistosomiasis in sub-Saharan Africa have had limited success, primarily because they fail to engage with the social, political, economic and ecological contexts in which they are delivered. Despite the call to foster community engagement and to adapt interventions to local circumstances, programmes have rarely embraced such an approach. This article outlines a community co-designed process, based upon Human-Centered Design, to demonstrate how this approach works in practice. It is based on initial work undertaken by social science researchers, public health practitioners and community members from the Zanzibar Islands, Tanzania, between November 2011 and December 2013. During the process, 32 community members participated in a qualitative and quantitative data-driven workshop where they interpreted data on local infections from S. haematobium and co-designed interventions with the assistance of a facilitator trained in the social sciences. These interventions included the implementation of novel school-based education and training, the identification of relevant safe play activities and events at local schools, the installation of community-designed urinals for boys and girls and the installation of community-designed laundry-washing platforms to reduce exposure to cercariae-contaminated fresh water. It is suggested that the a community co-designed process, drawing from Human-Centered Design principles and techniques, enables the development of more sustainable and effective interventions for the control of schistosomiasis. PMID:27428066

  7. Spatiotemporal Patterns of Schistosomiasis-Related Deaths, Brazil, 2000-2011.

    PubMed

    Martins-Melo, Francisco Rogerlândio; Pinheiro, Marta Cristhiany Cunha; Ramos, Alberto Novaes; Alencar, Carlos Henrique; Bezerra, Fernando Schemelzer de Moraes; Heukelbach, Jorg

    2015-10-01

    We analyzed spatiotemporal patterns of 8,756 schistosomiasis-related deaths in Brazil during 2000-2011 and identified high-risk clusters of deaths, mainly in highly schistosomiasis-endemic areas along the coast of Brazil's Northeast Region. Schistosomiasis remains a neglected public health problem with a high number of deaths in disease-endemic and emerging focal areas.

  8. Resources to Support Ethical Practice in Evaluation: An Interview with the Director of the National Center for Research and Professional Ethics

    ERIC Educational Resources Information Center

    Goodyear, Leslie

    2012-01-01

    Where do evaluators find resources on ethics and ethical practice? This article highlights a relatively new online resource, a centerpiece project of the National Center for Professional and Research Ethics (NCPRE), which brings together information on best practices in ethics in research, academia, and business in an online portal and center. It…

  9. The role of climate on prevalence or eradication of vesical schistosomiasis in Khuzestan Province of Iran.

    PubMed

    Hamidinia, Dariush; Maraghi, Sharif; Azimi, Farideh; Ai, Armin; Shirian, Sadegh

    2016-06-01

    Climate is defined as the combination of climate and air elements of a given region which is usually measured for a period of decades. De-marton climate classification has been established based on many factors, including elements such as temperature and rainfall. Vesicle schistosomiasis is a parasitic disease caused by Schistosoma haematobium. This parasite lives in the blood vessels of the bladder. The parasite can cause hematuria in human and if not treated properly can lead to vesicale carcinoma. The parasite is distributed only in certain parts of the province and it is highly dispersed along the rivers of Dez, Karkheh and Karun with high emissions. In 1970, the prevalence of infection in infected foci was 23.8 %. Campaign against the parasite began in 1958 but it did not encompass all centers of infection. Preventive measures include diagnosis and treatment of patients, public health promotion, health education, drying swamps and ponds, improving the environment, cementing the irrigation canals, and the use of moluscocide eventually leads to changing the ecological and conditions of parasite and snail inhabits. Application of preventive measures resulted in the reduction of infection level to 0.7 % in 1979. By continuing struggle and intensifying preventive measures and changing ecological and climatic environment, in 2008, the examination of 3400 urine samples of students in Andimeshk district revealed no cases of the vesical schistosomiasis. It is concluded that S. haematobium and vesical schistosomiasis is eliminated from Khuzestan province southwest Iran, but the disease is still prevalent in neighboring Iran's western border country (Iraq) and due to the special conditions of its facilities and the traffic between the two countries, it is necessary to control and eradicate the disease in Iraq by using the experiences of Iran in eliminating the disease. PMID:27413310

  10. David Grant Medical Center energy use baseline and integrated resource assessment

    SciTech Connect

    Richman, E.E.; Hoshide, R.K.; Dittmer, A.L.

    1993-04-01

    The US Air Mobility Command (AMC) has tasked Pacific Northwest Laboratory (PNL) with supporting the US Department of Energy (DOE) Federal Energy Management Program's (FEMP) mission to identify, evaluate, and assist in acquiring all cost-effective energy resource opportunities (EROs) at the David Grant Medical Center (DGMC). This report describes the methodology used to identify and evaluate the EROs at DGMC, provides a life-cycle cost (LCC) analysis for each ERO, and prioritizes any life-cycle cost-effective EROs based on their net present value (NPV), value index (VI), and savings to investment ratio (SIR or ROI). Analysis results are presented for 17 EROs that involve energy use in the areas of lighting, fan and pump motors, boiler operation, infiltration, electric load peak reduction and cogeneration, electric rate structures, and natural gas supply. Typical current energy consumption is approximately 22,900 MWh of electricity (78,300 MBtu), 87,600 kcf of natural gas (90,300 MBtu), and 8,300 gal of fuel oil (1,200 MBtu). A summary of the savings potential by energy-use category of all independent cost-effective EROs is shown in a table. This table includes the first cost, yearly energy consumption savings, and NPV for each energy-use category. The net dollar savings and NPV values as derived by the life-cycle cost analysis are based on the 1992 federal discount rate of 4.6%. The implementation of all EROs could result in a yearly electricity savings of more than 6,000 MWh or 26% of current yearly electricity consumption. More than 15 MW of billable load (total billed by the utility for a 12-month period) or more than 34% of current billed demand could also be saved. Corresponding natural gas savings would be 1,050 kcf (just over 1% of current consumption). Total yearly net energy cost savings for all options would be greater than $343,340. This value does not include any operations and maintenance (O M) savings.

  11. David Grant Medical Center energy use baseline and integrated resource assessment

    SciTech Connect

    Richman, E.E.; Hoshide, R.K.; Dittmer, A.L.

    1993-04-01

    The US Air Mobility Command (AMC) has tasked Pacific Northwest Laboratory (PNL) with supporting the US Department of Energy (DOE) Federal Energy Management Program`s (FEMP) mission to identify, evaluate, and assist in acquiring all cost-effective energy resource opportunities (EROs) at the David Grant Medical Center (DGMC). This report describes the methodology used to identify and evaluate the EROs at DGMC, provides a life-cycle cost (LCC) analysis for each ERO, and prioritizes any life-cycle cost-effective EROs based on their net present value (NPV), value index (VI), and savings to investment ratio (SIR or ROI). Analysis results are presented for 17 EROs that involve energy use in the areas of lighting, fan and pump motors, boiler operation, infiltration, electric load peak reduction and cogeneration, electric rate structures, and natural gas supply. Typical current energy consumption is approximately 22,900 MWh of electricity (78,300 MBtu), 87,600 kcf of natural gas (90,300 MBtu), and 8,300 gal of fuel oil (1,200 MBtu). A summary of the savings potential by energy-use category of all independent cost-effective EROs is shown in a table. This table includes the first cost, yearly energy consumption savings, and NPV for each energy-use category. The net dollar savings and NPV values as derived by the life-cycle cost analysis are based on the 1992 federal discount rate of 4.6%. The implementation of all EROs could result in a yearly electricity savings of more than 6,000 MWh or 26% of current yearly electricity consumption. More than 15 MW of billable load (total billed by the utility for a 12-month period) or more than 34% of current billed demand could also be saved. Corresponding natural gas savings would be 1,050 kcf (just over 1% of current consumption). Total yearly net energy cost savings for all options would be greater than $343,340. This value does not include any operations and maintenance (O&M) savings.

  12. Design of schistosomiasis ontology (IDOSCHISTO) extending the infectious disease ontology.

    PubMed

    Camara, Gaoussou; Despres, Sylvie; Djedidi, Rim; Lo, Moussa

    2013-01-01

    Epidemiological monitoring of the schistosomiasis' spreading brings together many practitioners working at different levels of granularity (biology, host individual, host population), who have different perspectives (biology, clinic and epidemiology) on the same phenomenon. Biological perspective deals with pathogens (e.g. life cycle) or physiopathology while clinical perspective deals with hosts (e.g. healthy or infected host, diagnosis, treatment, etc.). In an epidemiological perspective corresponding to the host population level of granularity, the schistosomiasis disease is characterized according to the way (causes, risk factors, etc.) it spreads in this population over space and time. In this paper we provide an ontological analysis and design for the Schistosomiasis domain knowledge and spreading dynamics. IDOSCHISTO - the schistosomiasis ontology - is designed as an extension of the Infectious Disease Ontology (IDO). This ontology aims at supporting the schistosomiasis monitoring process during a spreading crisis by enabling data integration, semantic interoperability, for collaborative work on one hand and for risk analysis and decision making on the other hand. PMID:23920598

  13. Urinary schistosomiasis and malaria associated anemia in Ethiopia

    PubMed Central

    Deribew, Ketema; Tekeste, Zinaye; Petros, Beyene

    2013-01-01

    Objective To assess the prevalence of anemia in children with urinary schistosomiasis, malaria and concurrent infections by the two diseases. Methods Urine and blood samples were collected from 387 children (216 males and 171 females) to examine urinary schistosomiasis and malaria and to determine hemoglobin concentration at Hassoba and Hassoba Buri village in Amibara woreda, Afar region, Ethiopia. Results The overall prevalence of urinary schistosomiasis and Plasmodium falciparum malaria was 24.54% and 6.20% respectively. Only 2.84% of children carried concurrent infections of both parasites. There was high percentage of anemic patients (81.81%) in the coinfected cases than in either malaria (33.3%) or schistosomiasis (38.94%) cases. There was significantly low mean hemoglobin concentration in concurrently infected children than non-infected and single infected (P<0.05). The mean hemoglobin concentration between Plasmodium falciparum and S. haematobium infected children showed no significant difference (P>0.05). The level of hemoglobin was negatively correlated with the number of S. haematobium eggs/10 mL urine (r=-0.6) and malaria parasitemia (r=-0.53). Conclusions The study showed that anemia is higher in concurrently infected children than non-infected and single infected. Furthermore, level of hemoglobin was negatively correlated with the number of S. haematobium eggs and malaria parsitemia. Therefore, examination of hemoglobin status in patients co-infected with malaria and schistosomiasis is important to reduce the risk of anemia and to improve health of the community. PMID:23620856

  14. NASA Space Engineering Research Center for Utilization of Local Planetary Resources

    NASA Technical Reports Server (NTRS)

    Ramohalli, Kumar; Lewis, John S.

    1991-01-01

    In the processing of propellants, volatiles, and metals subject area, the following topics are discussed: reduction of lunar regolith; reduction of carbon dioxide; and reduction of carbonaceous materials. Other areas addressed include: (1) production of structural and refractory materials; (2) resource discovery and characterization; (3) system automation and optimization; and (4) database development. The majority of these topics are discussed with respect to the development of lunar and mars bases. Some main topics of interest include: asteroid resources, lunar resources, mars resources, materials processing, construction materials, propellant production, oxygen production, and space-based oxygen production plants.

  15. Report on the Activities of the Single Parent Resource Center, 1975-1976.

    ERIC Educational Resources Information Center

    Childcare Switchboard / Single Parent Resource Center, San Francisco, CA.

    This report provides a model for the provision of social services to single parents. The activities the center provides include drop-in support groups, workshops on single parent issues, a single parent magazine, individual counseling and community outreach. The report briefly specifies the goals of the center and the rationale behind its…

  16. How to Set Up a Resource Center to be Compatible with an Outdoor Program.

    ERIC Educational Resources Information Center

    Stilson, Jan

    A materials collection can provide indirect experiences that will supplement the direct learning experiences offered by an outdoor education nature center. The Instructional Materials Center at Lorado Taft Field Campus provides such multiple learning experiences as it offers print media as well as slides, films, tapes, and projection and field…

  17. Oversight on NIOSH: Educational Resource Centers. Hearing before the Subcommittee on Education and Labor. House of Representatives, Ninety-Ninth Congress, First Session, June 18, 1985.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Education and Labor.

    Educational Resource Centers (ERC), which are funded by the National Institute for Occupational Safety and Health, are considered in these hearings. Attention is directed to how four centers are fulfilling their mission, special programs at the centers, and possible future projects. ERCs, which are located at 15 regional public and private…

  18. Underutilization of Student-Centered Resources: Understanding Student Response to Supports for Improved Institutional Practice

    ERIC Educational Resources Information Center

    Craft, Rebecca W.

    2013-01-01

    Nationwide, students enrolled in community colleges respond to national surveys indicating that academic resources are very important, while at the same time failing to utilize those same resources. This study focused on identifying the reasons for this incongruity on the Terry Campus of Delaware Technical Community College. Using a sequential…

  19. Experimental schistosomiasis in primates in Tanzania

    PubMed Central

    Jordan, P.; von Lichtenberg, F.; Goatly, K. D.

    1967-01-01

    Laboratory infection of animals with Schistosoma haematobium is generally unsatisfactory as adult worms invariably inhabit the portal venous system rather than the vesical plexus as in man. However, it was thought that certain primates might prove more valuable for experimental studies of schistosomiasis than the usual laboratory animals. Baboons, Papio anubis, were therefore exposed to cercariae of S. haematobium and the pattern of egg excretion in stools and urine was followed quantitatively. Histological studies of various organs were made and it was found that although eggs were excreted in the faeces, they were also passed in the urine and that tissue changes in the bladder were similar to those found in human infections. It is suggested that the sequelae of S. haematobium infection found in man might develop in baboons and that the animal may be useful for studying their development in the laboratory. ImagesFIG. 3FIG. 8FIG. 11FIG. 4FIG. 10FIG. 9FIG. 6FIG. 7FIG. 5 PMID:4968348

  20. Epidemiology and control of human schistosomiasis in Tanzania

    PubMed Central

    2012-01-01

    In Tanzania, the first cases of schistosomiasis were reported in the early 19th century. Since then, various studies have reported prevalences of up to 100% in some areas. However, for many years, there have been no sustainable control programmes and systematic data from observational and control studies are very limited in the public domain. To cover that gap, the present article reviews the epidemiology, malacology, morbidity, and the milestones the country has made in efforts to control schistosomiasis and discusses future control approaches. The available evidence indicates that, both urinary and intestinal schistosomiasis are still highly endemic in Tanzania and cause significant morbidity.Mass drug administration using praziquantel, currently used as a key intervention measure, has not been successful in decreasing prevalence of infection. There is therefore an urgent need to revise the current approach for the successful control of the disease. Clearly, these need to be integrated control measures. PMID:23192005

  1. The challenges and strategies in schistosomiasis control program in China.

    PubMed

    Xianyi, Chen

    2002-05-01

    In spite of the great achievements gained in the national schistosomiasis control program during the last 5 decades, serious challenges for the control program exist due to the impact of biological factors, environmental facts and limitation of scientific technology, as well as shortages of socio-economic development in the endemic areas. This paper reviewed the experiences of the national control program, then the author considered it essential to put forward a newly sustainable strategy with an emphasis on the areas with high endemicity of schistosomiasis, on poverty-stricken areas, especially in the Western part of the People's Republic of China, when taking into account both the opportunities and challenges of the future. It is expected that the schistosomiasis control program with a sustainable strategy would promote local economic development in the People's Republic of China. PMID:12020901

  2. The Establishment and Function of Schistosomiasis Surveillance System Towards Elimination in The People's Republic of China.

    PubMed

    Zhang, L-J; Li, S-Z; Wen, L-Y; Lin, D-D; Abe, E M; Zhu, R; Du, Y; Lv, S; Xu, J; Webster, B L; Rollinson, D; Zhou, X-N

    2016-01-01

    Schistosoma japonicum is the main schistosome species in The People's Republic of China, causing intestinal schistosomiasis, a debilitating disease of public health importance. The People's Republic of China used to be heavily endemic with schistosomiasis, but great progress has been made through the vigorous efforts of the national control programmes in the last six decades. Presently, efforts are geared towards eliminating schistosomiasis from The People's Republic of China by the end of 2025 through effective schistosomiasis surveillance, an important component in the drive towards schistosomiasis elimination. Therefore, this article explicitly outlines the development and progress made in schistosomiasis surveillance since 1990 with a special focus on the new surveillance system in use. Although the surveillance system has steadily improved over the years, it is faced with many challenges. Hence, more efforts are needed to establish an effective and sensitive evaluation system for the national schistosomiasis elimination programme in The People's Republic of China. PMID:27137445

  3. St. Edward Mercy Medical Center, Fort Smith, AR. Human resource planning identifies institutional need, available personnel.

    PubMed

    Keith, J M

    1981-04-01

    Human resource planning, which allows health care facilities to identify future staffing needs and to project staffing availability, will increase as institutions seek to balance quality, costs, employees' needs.

  4. 76 FR 36556 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... Institutes of Health/NCRR/OR, Democracy 1, 6701 Democracy Blvd., 1064, Bethesda, MD 20892 (Virtual Meeting... Resources, or National Institutes of Health, 6701 Democracy Boulevard, 1 Democracy Plaza, Room 1064,...

  5. 76 FR 51995 - National Center for Research Resources; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    ...: National Institutes of Health/NCRR/OR, Democracy 1, 6701 Democracy Blvd., 1064, Bethesda, MD. (Virtual... for Research Resources, National Institutes of Health, 6701 Democracy Blvd., DEM. 1, Room 1064,...

  6. 75 FR 28262 - National Center for Research Resources; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... Health, NCRR, OR, One Democracy Plaza, 6701 Democracy Blvd., Rm. 1064, Bethesda, MD 20892. Contact Person... Resources, National Institutes of Health, 6701 Democracy Blvd., 1 Democracy Plaza, Rm. 1064, Bethesda,...

  7. Advancing survivorship care through the National Cancer Survivorship Resource Center: developing American Cancer Society guidelines for primary care providers.

    PubMed

    Cowens-Alvarado, Rebecca; Sharpe, Katherine; Pratt-Chapman, Mandi; Willis, Anne; Gansler, Ted; Ganz, Patricia A; Edge, Stephen B; McCabe, Mary S; Stein, Kevin

    2013-05-01

    The National Cancer Survivorship Resource Center (The Survivorship Center) began in 2010 as a collaboration between the American Cancer Society and the George Washington University Cancer Institute and was funded by the Centers for Disease Control and Prevention. The Survivorship Center aims to improve the overall health and quality of life of posttreatment cancer survivors. One key to addressing the needs of this ever-growing population is to develop clinical follow-up care guidelines that emphasize not only the importance of surveillance for cancer recurrence, but also address the assessment and management of the physical and psychosocial long-term and late effects that may result from having cancer and undergoing cancer treatment as well as highlight the importance of healthy behaviors that can reduce the risk of cancer recurrence, second primary cancers, and other chronic diseases. Currently, The Survivorship Center is coordinating the work of experts in oncology, primary care, and other health care professions to develop follow-up care guidelines for 10 priority cancer sites.

  8. [Role of the new version of the Control and Elimination Criteria for Schistosomiasis in acceleration of the schistosomiasis elimination program in China].

    PubMed

    Zhou, Xiao-Nong; Xu, Jing; Lin, Dan-Dan; Wang, Tian-Ping; Liang, You-Sheng; Zhong, Bo; Li, Shi-Zhu; Yang, Guo-Jing; Jiang, Qing-Wu

    2013-02-01

    Based on the historical background for revision of the Control and Elimination Criteria for Schistosomiasis for 6 times, and the role of the criteria in promotion of national schistosomiasis control program of China at various stages, the present study demonstrated the necessity of further revision of the control criteria in the current schistosomiasis elimination program. In addition, the background for revision of the novel version of the Control and Elimination Criteria for Schistosomiasis was illustrated based on literature review, retrospective survey, expert argumentation and index improvement.

  9. Epidemiology and control of schistosomiasis: present situation and priorities for further research*

    PubMed Central

    1978-01-01

    The article highlights specific aspects of the epidemiology of schistosomiasis where insufficient data are available on which to base appropriate control strategies. Emphasis is placed on the part that immunological techniques might play in improving the baseline epidemiological data. A study of acquired resistance to the disease is also important in relation to epidemiology and control. The clinical manifestations of the disease vary in different areas and further study of the relation between the clinical and pathological manifestations are therefore required. In relation to the intermediate host, the main priority for research concerns the definition of the location and time-patterns of transmission foci within any particular area: variations in transmission are of particular importance in relation to man-made water resources. Although chemotherapy will play an increasing role in control, its importance will depend on local conditions: coordinated and standardized trials are required of chemotherapeutic agents in different regions and in various defined groups of subjects. The effects of chemotherapy on immunity to reinfection and on immunopathology also require study. With all types of snail control—chemical, ecological, and biological—cost-effectiveness aspects are important. With chemicals, it is important to bear in mind other possible effects on the environment. In the field of water supplies and sanitation, several aspects are important in relation to schistosomiasis transmission and community involvement should be encouraged. PMID:308404

  10. Urban schistosomiasis and soil transmitted helminthiases in young school children in Dar es Salaam and Tanga, Tanzania, after a decade of anthelminthic intervention.

    PubMed

    Mwakitalu, Mbutolwe E; Malecela, Mwele N; Mosha, Franklin W; Simonsen, Paul E

    2014-05-01

    Rapid urbanization in resource poor countries often results in expansion of unplanned settlements with overcrowding and inadequate sanitation. These conditions potentially support transmission of schistosomiasis and soil transmitted helminths (STH), but knowledge on the occurrence, transmission and control of these infections in urban settings is limited. The present study assessed the status of urinary schistosomiasis and STH across two different-sized cities in Tanzania - Dar es Salaam and Tanga - after a decade of anthelminthic intervention. Primary school children were examined for parasite eggs in urine and stool. Questionnaires were administered to the children, and observations were made on the urban environments. The burden of urinary schistosomiasis and STH was found to be low in both cities (overall 1.2% in Dar es Salaam and 0.3% in Tanga for urinary schistosomiasis; overall <1% in Dar es Salaam and 1-2% in Tanga for each STH infection), and the identified cases showed no clear pattern of spatial distribution. The findings indicated that a marked decrease in prevalence of these infections had occurred in the two cities during recent years. The observed promising developments appeared to have been accomplished by implementation of drug based intervention programs, in combination with environmental change (fewer snail habitats) and generally improved levels of hygiene. Continued efforts, including anthelminthic treatment and health education, are important to maintain these positive achievements.

  11. 77 FR 42546 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-19

    ... June 15, 2012, 77 FR 36034. USDOT OSDBU is extending the closing date to allow eligible entities time... Center Program AGENCY: Department of Transportation (DOT), Office of the Secretary of Transportation (OST....martin@dot.gov . SUPPLEMENTARY INFORMATION: In the June 15, 2012 document (Notice No....

  12. 78 FR 70617 - Notice of Funding Availability for the Small Business Transportation Resource Center Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ... Center Program AGENCY: Department of Transportation (DOT), Office of the Secretary of Transportation (OST... (OST), Office of Small and Disadvantaged Business Utilization (OSDBU) announces the opportunity for; (1... Opportunity Number: USDOT-OST-OSDBU-SBTRC2014NWRSBTRC-1. Catalog of Federal Domestic Assistance (CFDA)...

  13. Rescuing the Childcare Center: One Community's Efforts to Manage Change through Generating and Coordinating Resources

    ERIC Educational Resources Information Center

    Yetmar, Jaclyn; Uhlenberg, Jill M.; May, Charles R.; Traw, Rick C.

    2006-01-01

    Childcare centers are business organizations and are subject to some of the same issues and problems as any small business. Many childcare administrators have little or no business training, and are unable to embrace change in order to help their programs survive economic problems. This article describes how one community saved their childcare…

  14. A Population-Family Planning Resource Center: A Community Educational Service

    ERIC Educational Resources Information Center

    Berde, Carol

    1974-01-01

    The author discusses a multi-media library and information center in population and family planning which is associated with a Planned Parenthood affiliate and provides many segments of the community with educational materials and services and strengthens the affiliate's programs. (Author)

  15. Family Literacy Project. Learning Centers for Parents and Children. A Resource Guide.

    ERIC Educational Resources Information Center

    Crocker, M. Judith, Ed.; And Others

    This guide is intended to help adult education programs establish family literacy programs and create Family Learning Centers in Cleveland Public Schools. The information should assist program coordinators in developing educational components that offer activities to raise the self-esteem of the parents and provide them with the knowledge and…

  16. Bilingual Program in a Community Correctional Center: Sharing Problems, Ideas, Experiences, and Resource Information.

    ERIC Educational Resources Information Center

    Pinton, Giorgio A.

    The bilingual education of adults in correctional institutions is discussed. The program specifically described is a bilingual/ESL (English as a second language) program for Puerto Rican adults in a Connecticut correctional center. The study has two sections: (1) the Puerto Rican adult in a penal institution; an explanation of his needs and an…

  17. NASA Space Engineering Research Center for utilization of local planetary resources

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Reports covering the period from 1 Nov. 1991 to 31 Oct. 1992 and documenting progress at the NASA Space Engineering Research Center are included. Topics covered include: (1) processing of propellants, volatiles, and metals; (2) production of structural and refractory materials; (3) system optimization discovery and characterization; (4) system automation and optimization; and (5) database development.

  18. Tribal Business Information Centers: A Wealth of New Resources for Indian Communities.

    ERIC Educational Resources Information Center

    Wakshul, Barbra

    1996-01-01

    Quanah Crossland Stamps, assistant administrator of the Small Business Administration, describes a pilot program establishing 17 reservation-based Tribal Business Information Centers (TBICs) in North Dakota, South Dakota, Montana, Wyoming, and the Navajo Nation. Managed by tribal colleges, TBICs offer business workshops, access to computer…

  19. Facility Management Child Care Resource Book. Child Care Operations Center of Expertise.

    ERIC Educational Resources Information Center

    General Services Administration, Washington, DC. Public Buildings Service.

    This guidebook provides maintenance and operations guidelines for managing General Services Administration (GSA) child care centers within the same standards and level of a GSA operated facility. Areas covered address cleaning standards and guidelines; equipment funding and inventory; maintenance of living environments and problem areas;…

  20. Center for fetal monkey gene transfer for heart, lung, and blood diseases: an NHLBI resource for the gene therapy community.

    PubMed

    Tarantal, Alice F; Skarlatos, Sonia I

    2012-11-01

    The goals of the National Heart, Lung, and Blood Institute (NHLBI) Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases are to conduct gene transfer studies in monkeys to evaluate safety and efficiency; and to provide NHLBI-supported investigators with expertise, resources, and services to actively pursue gene transfer approaches in monkeys in their research programs. NHLBI-supported projects span investigators throughout the United States and have addressed novel approaches to gene delivery; "proof-of-principle"; assessed whether findings in small-animal models could be demonstrated in a primate species; or were conducted to enable new grant or IND submissions. The Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases successfully aids the gene therapy community in addressing regulatory barriers, and serves as an effective vehicle for advancing the field.

  1. Amarillo National Resource Center for Plutonium. Quarterly technical progress report, May 1--July 31, 1998

    SciTech Connect

    1998-09-01

    Progress is reported on research projects related to the following: Electronic resource library; Environment, safety, and health; Communication, education, training, and community involvement; Nuclear and other materials; and Reporting, evaluation, monitoring, and administration. Technical studies investigate remedial action of high explosives-contaminated lands, radioactive waste management, nondestructive assay methods, and plutonium processing, handling, and storage.

  2. Yoga for Stress Management Program as a Complementary Alternative Counseling Resource in a University Counseling Center

    ERIC Educational Resources Information Center

    Milligan, Colleen K.

    2006-01-01

    A Yoga for Stress Management Program (YSMP) that served as a complementary alternative therapy resource was successfully implemented at a midsize, predominantly undergraduate university. It was offered in addition to traditional treatments for student mental health. Counselors, Residence Life staff, and faculty found that the program was useful…

  3. On the Cutting Edge of Change: The Community College Library/Learning Resource Center.

    ERIC Educational Resources Information Center

    Giles, Louise

    Community college libraries tend to be the pace setters for change in libraries. As the new media have been introduced into libraries, ways have been found to integrate them into the library to create multimedia resource collections. In addition to traditional library services, instructional design, materials production, computer operation,…

  4. Human Rights and Citizenship: A Community Resource Manual. Foreign Area Materials Center Occasional Publication 27.

    ERIC Educational Resources Information Center

    Nyquist, Corinne

    Human Rights Week (December 10-17) has been proclaimed by the U.S. President for a number of years because Bill of Rights Day (December 15) and Human Rights Day (December 10) are observed within a week's period. This comprehensive survey of resources for the study of human rights contains books, films, filmstrips, organizations, and learning…

  5. Overlap and Unique Titles in Selected Elementary School Media Centers with Implications for Resource Sharing.

    ERIC Educational Resources Information Center

    Kugel, Patricia M.

    This descriptive study investigated the numbers of unique and overlap titles in selected elementary schools which may influence resource-sharing decision making. A convenience sample of seven elementary schools in DeKalb County, Georgia, using the Follett Software Company's "Circulation Plus" system was used. Each school printed a shelf list…

  6. Agricultural Safety and Health: A Resource Guide. Rural Information Center Publication Series, No. 40. Revised Edition.

    ERIC Educational Resources Information Center

    Zimmerman, Joy, Comp.

    This guide lists resource materials that address agricultural occupational injuries and diseases and their prevention. Many of the entries were derived from the AGRICOLA database produced by the National Agricultural Library and include journal articles, books, government reports, training materials, and audiovisual materials. The first section…

  7. A Handbook of Resources for New Instructors at UTK from the Learning Research Center.

    ERIC Educational Resources Information Center

    Humphreys, W. Lee, Ed.; Wickersham, Barbara, Ed.

    Suggestions for graduate teaching assistants (TA) at the University of Tennessee, Knoxville, are offered. Information is provided on: the TA as a university employee, the instructor as a teacher/adviser, course management, classroom and evaluation concerns, and teaching resources. Definitions are offered for the graduate teaching assistant,…

  8. Multivalent anthelminthic vaccine to prevent hookworm and schistosomiasis.

    PubMed

    Hotez, Peter J; Bethony, Jeffrey M; Oliveira, Sergio Costa; Brindley, Paul J; Loukas, Alex

    2008-08-01

    Hookworm infection and schistosomiasis are two of the world's most important human parasitic infections, affecting hundreds of millions of people in developing countries. Measured together in disability-adjusted life years, hookworm infection and schistosomiasis rank closely behind malaria as the most prevalent human parasitic diseases. A major approach for the control of these two helminth infections relies on periodic, mass chemotherapy with anthelminthics. However, high rates of post-treatment reinfection, the declining efficacy with repeated treatment, rebound morbidity (in the case of schistosomiasis) and the potential for the emergence of anthelminthic drug resistance threaten the sustainability of mass drug administration as the only form of control. Hence, there is a strong rationale for developing a vaccine that simultaneously targets both hookworms and schistosomes because of similarities in the pathobiology of both parasites, the ability of both helminths to cause anemia and their coendemicity in sub-Saharan Africa, Brazil and East Asia. A multivalent anthelminthic vaccine for hookworm infection and schistosomiasis would represent an important new tool for combating disease and poverty.

  9. Schistosomiasis among Recreational Users of Upper Nile River, Uganda, 2007

    PubMed Central

    Brunette, Gary; Kapella, Bryan K.; McAuliffe, Isabel; Katongole-Mbidde, Edward; Li, Wenkai; Marano, Nina; Okware, Sam; Olsen, Sonja J.; Secor, W. Evan; Tappero, Jordan W.; Wilkins, Patricia P.; Montgomery, Susan P.

    2010-01-01

    After recreational exposure to river water in Uganda, 12 (17%) of 69 persons had evidence of schistosome infection. Eighteen percent self-medicated with praziquantel prophylaxis immediately after exposure, which was not appropriate. Travelers to schistosomiasis-endemic areas should consult a travel medicine physician. PMID:20409387

  10. Africa: Schistosomiasis in Africa and the Role of Environmental Education.

    ERIC Educational Resources Information Center

    Stapp, William B.

    1985-01-01

    Illustrates problems involved in controlling a public health disease (schistosomiasis) which is interwoven into a country's religious, economic, political, educational, and social systems. The strong relationship between the disease and development of irrigation systems is pointed out. A successful education and integrative program is described.…

  11. [Current risks in the introduction of schistosomiasis into French Guiana].

    PubMed

    Lalande, G; Picot, H

    1987-01-01

    At the moment, it seems unlikely that there is a possibility for schistosomiasis implantation in French Guiana. The reasons to this are both the number of the immigrants infested by Schistosoma mansoni which is quite low and the disappearance of the intermediate host Biomphalaria glabrata. The disappearance of the species may be a temporary one.

  12. Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series)

    PubMed Central

    2014-01-01

    Abstract Inflammation is associated with multiple forms of pulmonary arterial hypertension (PAH), including autoimmune (scleroderma) and infectious (HIV, schistosomiasis) etiologies. More than 200 million people worldwide are infected with Schistosoma, predominantly in Brazil, Africa, the Middle East, and South Asia. Schistosomiasis causes PAH in about 6.1% of those chronically infected and is particularly associated with the species Schistosoma mansoni. Treatment for schistosomiasis-associated PAH includes antihelminthic treatment, if active infection is present (although associated with little immediate benefit to the pulmonary hypertension), and then pharmacologic treatment with targeted pulmonary vascular therapies, including phosphodiesterase type 5 inhibitors and endothelin receptor antagonists. The pathophysiological mechanism by which this parasitic infection causes pulmonary hypertension is unknown but is unlikely to be simple mechanical obstruction of the pulmonary vasculature by parasite eggs. Preexisting hepatosplenic disease due to Schistosoma infection is likely important because of portopulmonary hypertension and/or because it allows egg embolization to the lung by portocaval shunts. Potential immune signaling originating in the periegg granulomas causing the pulmonary vascular disease includes the cytokines interleukin (IL)-4, IL-6, IL-13, and transforming growth factor β. Modulating these pathways may be possible targets for future therapy of schistosomiasis-associated PAH specifically, and study of this disease may provide novel insights into other inflammatory causes of PAH. PMID:25621148

  13. [Schistosomiasis in an ecotourism area in Minas Gerais State, Brazil].

    PubMed

    Massara, Cristiano Lara; Amaral, Graciela Larissa; Caldeira, Roberta Lima; Drummond, Sandra Costa; Enk, Martin Johannes; Carvalho, Omar dos Santos

    2008-07-01

    This paper discusses schistosomiasis transmission in São José da Serra, a village with a population of 500 in the county of Jaboticatubas, Minas Gerais State, Brazil. The area receives thousands of visitors a year for ecotourism. The study was motivated by a case of acute schistosomiasis involving a couple that spent the 2007 Carnival (Mardi Gras) holiday in the area. Stool tests from 268 local residents (53.6% of the population) showed that 35 (13%) were positive for the infection. A comparison with a previous survey (2005) in the same location showed an increase in the schistosomiasis-positive rate from 9.6% to 12.5%, among the 56 individuals who participated in both surveys. A malacological survey of 65 Biomphalaria glabrata snails showed one specimen (1.5%) eliminating cercariae. In a similar survey in 2005, no positive snail specimens were found. The study indicates that active schistosomiasis transmission is occurring in the area, and that integrated educational programs are needed for both the local community and tourists.

  14. NASA Langley Teacher Resource Center (TRC): Brochure and Home Page Design

    NASA Technical Reports Server (NTRS)

    Cogbill, Monet Leigh

    1995-01-01

    The NASA Langley Research Center's Educational Programs Officer, Marchelle D. Canright, gave me two main assignments to be completed by the end of the ten-week LARSS Program. These assignments were to redesign the NASA Langley Teacher Research Center (TRC) brochure and create new home page templates for the TRC and Office of Education. I worked with NASA Education Specialist, Jane George and the TRC director Nick Koltun for instruction in copmleting these assignments. The main objective of my assigned projects was to create designs that reflected NASA's educational goals, related to the TRC, and the Office of Education's desire for high aesthetics in their multimedia materials. The Office of Education did not just want their current TRC brochure and home page to be reworked, but; they wanted these items to be strong visual representations of the TRC's purpose.

  15. The Sharjah Center for Astronomy and Space Sciences (SCASS 2015): Concept and Resources

    NASA Astrophysics Data System (ADS)

    Naimiy, Hamid M. K. Al

    2015-08-01

    The Sharjah Center for Astronomy and Space Sciences (SCASS) was launched this year 2015 at the University of Sharjah in the UAE. The center will serve to enrich research in the fields of astronomy and space sciences, promote these fields at all educational levels, and encourage community involvement in these sciences. SCASS consists of:The Planetarium: Contains a semi-circle display screen (18 meters in diameter) installed at an angle of 10° which displays high-definition images using an advanced digital display system consisting of seven (7) high-performance light-display channels. The Planetarium Theatre offers a 200-seat capacity with seats placed at highly calculated angles. The Planetarium also contains an enormous star display (Star Ball - 10 million stars) located in the heart of the celestial dome theatre.The Sharjah Astronomy Observatory: A small optical observatory consisting of a reflector telescope 45 centimeters in diameter to observe the galaxies, stars and planets. Connected to it is a refractor telescope of 20 centimeters in diameter to observe the sun and moon with highly developed astronomical devices, including a digital camera (CCD) and a high-resolution Echelle Spectrograph with auto-giving and remote calibration ports.Astronomy, space and physics educational displays for various age groups include:An advanced space display that allows for viewing the universe during four (4) different time periods as seen by:1) The naked eye; 2) Galileo; 3) Spectrographic technology; and 4) The space technology of today.A space technology display that includes space discoveries since the launching of the first satellite in 1940s until now.The Design Concept for the Center (450,000 sq. meters) was originated by HH Sheikh Sultan bin Mohammed Al Qasimi, Ruler of Sharjah, and depicts the dome as representing the sun in the middle of the center surrounded by planetary bodies in orbit to form the solar system as seen in the sky.

  16. NASA Space Engineering Research Center for utilization of local planetary resources

    NASA Technical Reports Server (NTRS)

    1990-01-01

    In 1987, responding to widespread concerns about both the health of American space technology development and the academic preparation of 21st-century space professionals, NASA announced a nationwide competition to establish a number of Space Engineering Research Centers. These centers were to be founded on the campuses of nine Universities with strong Doctoral programs in Engineering. Over 115 proposals were received by NASA in November 1987. The University of Arizona's proposal was selected in May as one of the winners, with a budget of approximately $7 million guaranteed by NASA for a minimum funding period of five years. The role of the University of Arizona SERC is to develop the technologies necessary to produce a wide variety of useful products using the materials and sources of energy that occur naturally in near-Earth space. An additional purpose is to lower the cost and extend the scope of large-scale activities. A brief description of the Center's activities for the 1989-1990 period is presented.

  17. [Laboral health in Penitentiary Center of Chile: a look from policies of human resources].

    PubMed

    Güilgüiruca R, M; Herrera-Bascur, J

    2015-01-01

    This article examines the influence of human resources policies on occupational health variables, such as engagement and job satisfaction, with regard to Chilean prison employees. 80 workers at the Women's Prison of Iquique were evaluated and results show that 77% and 88 % have a moderate to high score in terms of engagement and job satisfaction respectively. The 24% variation in engagement of the workers studied can be explained by policies aimed at promoting personal interests, while 32% of the variation in job satisfaction could be explained by policies of self-efficacy and personal interests. The above data permits the assertion to be made that human resources policies have a role that is relevant and necessary to modify and improve the occupational health conditions of these public sector workers. PMID:25803113

  18. [Laboral health in Penitentiary Center of Chile: a look from policies of human resources].

    PubMed

    Güilgüiruca R, M; Herrera-Bascur, J

    2015-01-01

    This article examines the influence of human resources policies on occupational health variables, such as engagement and job satisfaction, with regard to Chilean prison employees. 80 workers at the Women's Prison of Iquique were evaluated and results show that 77% and 88 % have a moderate to high score in terms of engagement and job satisfaction respectively. The 24% variation in engagement of the workers studied can be explained by policies aimed at promoting personal interests, while 32% of the variation in job satisfaction could be explained by policies of self-efficacy and personal interests. The above data permits the assertion to be made that human resources policies have a role that is relevant and necessary to modify and improve the occupational health conditions of these public sector workers.

  19. Impact of human schistosomiasis in sub-Saharan Africa.

    PubMed

    Adenowo, Abiola Fatimah; Oyinloye, Babatunji Emmanuel; Ogunyinka, Bolajoko Idiat; Kappo, Abidemi Paul

    2015-01-01

    Schistosomiasis, a neglected tropical disease of poverty ranks second among the most widespread parasitic disease in various nations in sub-Saharan Africa. Neglected tropical diseases are causes of about 534,000 deaths annually in sub-Saharan Africa and an estimated 57 million disability-adjusted life-years are lost annually due to the neglected tropical diseases. The neglected tropical diseases exert great health, social and financial burden on economies of households and governments. Schistosomiasis has profound negative effects on child development, outcome of pregnancy, and agricultural productivity, thus a key reason why the "bottom 500 million" inhabitants of sub-Saharan Africa continue to live in poverty. In 2008, 17.5 million people were treated globally for schistosomiasis, 11.7 million of those treated were from sub-Saharan Africa. This enervating disease has been successfully eradicated in Japan, as well as in Tunisia. Morocco and some Caribbean Island countries have made significant progress on control and management of this disease. Brazil, China and Egypt are taking steps towards elimination of the disease, while most sub-Saharan countries are still groaning under the burden of the disease. Various factors are responsible for the continuous and persistent transmission of schistosomiasis in sub-Saharan Africa. These include climatic changes and global warming, proximity to water bodies, irrigation and dam construction as well as socio-economic factors such as occupational activities and poverty. The morbidity and mortality caused by this disease cannot be overemphasized. This review is an exposition of human schistosomiasis as it affects the inhabitants of various communities in sub-Sahara African countries. It is hoped this will bring a re-awakening towards efforts to combat this impoverishing disease in terms of vaccines development, alternative drug design, as well as new point-of-care diagnostics. PMID:25636189

  20. Time to set the agenda for schistosomiasis elimination.

    PubMed

    Rollinson, David; Knopp, Stefanie; Levitz, Sarah; Stothard, J Russell; Tchuem Tchuenté, Louis-Albert; Garba, Amadou; Mohammed, Khalfan A; Schur, Nadine; Person, Bobbie; Colley, Daniel G; Utzinger, Jürg

    2013-11-01

    It is time to raise global awareness to the possibility of schistosomiasis elimination and to support endemic countries in their quest to determine the most appropriate approaches to eliminate this persistent and debilitating disease. The main interventions for schistosomiasis control are reviewed, including preventive chemotherapy using praziquantel, snail control, sanitation, safe water supplies, and behaviour change strategies supported by information, education and communication (IEC) materials. Differences in the biology and transmission of the three main Schistosoma species (i.e. Schistosoma haematobium, S. mansoni and S. japonicum), which impact on control interventions, are considered. Sensitive diagnostic procedures to ensure adequate surveillance in areas attaining low endemicity are required. The importance of capacity building is highlighted. To achieve elimination, an intersectoral approach is necessary, with advocacy and action from local communities and the health community to foster cooperative ventures with engineers, the private sector, governments and non-governmental organizations specialized in water supply and sanitation. Examples of successful schistosomiasis control programmes are reviewed to highlight what has been learnt in terms of strategy for control and elimination. These include St. Lucia and other Caribbean islands, Brazil and Venezuela for S. mansoni; Saudi Arabia and Egypt for both S. mansoni and S. haematobium; Morocco, Tunisia, Algeria, Mauritius and the Islamic Republic of Iran for S. haematobium; Japan and the People's Republic of China for S. japonicum. Additional targets for elimination or even eradication could be the two minor human schistosome species S. guineenisis and S. intercalatum, which have a restricted distribution in West and Central Africa. The examples show that elimination of schistosomiasis is an achievable and desirable goal requiring full integration of preventive chemotherapy with the tools of transmission

  1. Impact of human schistosomiasis in sub-Saharan Africa.

    PubMed

    Adenowo, Abiola Fatimah; Oyinloye, Babatunji Emmanuel; Ogunyinka, Bolajoko Idiat; Kappo, Abidemi Paul

    2015-01-01

    Schistosomiasis, a neglected tropical disease of poverty ranks second among the most widespread parasitic disease in various nations in sub-Saharan Africa. Neglected tropical diseases are causes of about 534,000 deaths annually in sub-Saharan Africa and an estimated 57 million disability-adjusted life-years are lost annually due to the neglected tropical diseases. The neglected tropical diseases exert great health, social and financial burden on economies of households and governments. Schistosomiasis has profound negative effects on child development, outcome of pregnancy, and agricultural productivity, thus a key reason why the "bottom 500 million" inhabitants of sub-Saharan Africa continue to live in poverty. In 2008, 17.5 million people were treated globally for schistosomiasis, 11.7 million of those treated were from sub-Saharan Africa. This enervating disease has been successfully eradicated in Japan, as well as in Tunisia. Morocco and some Caribbean Island countries have made significant progress on control and management of this disease. Brazil, China and Egypt are taking steps towards elimination of the disease, while most sub-Saharan countries are still groaning under the burden of the disease. Various factors are responsible for the continuous and persistent transmission of schistosomiasis in sub-Saharan Africa. These include climatic changes and global warming, proximity to water bodies, irrigation and dam construction as well as socio-economic factors such as occupational activities and poverty. The morbidity and mortality caused by this disease cannot be overemphasized. This review is an exposition of human schistosomiasis as it affects the inhabitants of various communities in sub-Sahara African countries. It is hoped this will bring a re-awakening towards efforts to combat this impoverishing disease in terms of vaccines development, alternative drug design, as well as new point-of-care diagnostics.

  2. NASA Space Engineering Research Center for Utilization of Local Planetary Resources

    NASA Technical Reports Server (NTRS)

    Ramohalli, Kumar; Lewis, John S.

    1989-01-01

    Progress toward the goal of exploiting extraterrestrial resources for space missions is documented. Some areas of research included are as follows: Propellant and propulsion optimization; Automation of propellant processing with quantitative simulation; Ore reduction through chlorination and free radical production; Characterization of lunar ilmenite and its simulants; Carbothermal reduction of ilmenite with special reference to microgravity chemical reactor design; Gaseous carbonyl extraction and purification of ferrous metals; Overall energy management; and Information management for space processing.

  3. Nonfuel mineral resources in the United States-Mexico border region; a progress report on information available from the Center for Inter-American Mineral Resource Investigations (CIMRI)

    USGS Publications Warehouse

    Orris, G.J.; Page, N.J.; Staude, J.G.; Bolm, K.S.; Carbonaro, M.M.; Gray, Floyd; Long, K.R.

    1993-01-01

    The exploitation of minerals has played a significant role in population growth and development of the U.S.Mexico border region. Recent proposed changes in regulations related to mining in the United States and changes in mining and investment regulations in Mexico have led to increased mineral exploration and development in Mexico, especially in the border region. As a preliminary step in the study of the mineral industry of this area, the Center for Inter-American Mineral Resource Investigations (CIMRI) of the U.S. Geological Survey has compiled mine and occurrence data for nonfuel minerals in the border region. Analysis of this information indicates that a wide variety of metallic and industrial mineral commodities are present which can be used in agriculture, infrastructure, environmental improvement, and other industries. Therefore, mining will continue to play a significant role in the economy of this region.

  4. U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center-fiscal year 2010 annual report

    USGS Publications Warehouse

    Nelson, Janice S.

    2011-01-01

    The Earth Resources Observation and Science (EROS) Center is a U.S. Geological Survey (USGS) facility focused on providing science and imagery to better understand our Earth. The work of the Center is shaped by the earth sciences, the missions of our stakeholders, and implemented through strong program and project management, and application of state-of-the-art information technologies. Fundamentally, EROS contributes to the understanding of a changing Earth through 'research to operations' activities that include developing, implementing, and operating remote-sensing-based terrestrial monitoring capabilities needed to address interdisciplinary science and applications objectives at all levels-both nationally and internationally. The Center's programs and projects continually strive to meet, and where possible exceed, the changing needs of the USGS, the Department of the Interior, our Nation, and international constituents. The Center's multidisciplinary staff uses their unique expertise in remote sensing science and technologies to conduct basic and applied research, data acquisition, systems engineering, information access and management, and archive preservation to address the Nation's most critical needs. Of particular note is the role of EROS as the primary provider of Landsat data, the longest comprehensive global land Earth observation record ever collected. This report is intended to provide an overview of the scientific and engineering achievements and illustrate the range and scope of the activities and accomplishments at EROS throughout fiscal year (FY) 2010. Additional information concerning the scientific, engineering, and operational achievements can be obtained from the scientific papers and other documents published by EROS staff or by visiting our web site at http://eros.usgs.gov. We welcome comments and follow-up questions on any aspect of this Annual Report and invite any of our customers or partners to contact us at their convenience. To

  5. Establishment of the South-Eastern Norway Regional Health Authority Resource Center for Children with Prenatal Alcohol/Drug Exposure

    PubMed Central

    Løhaugen, Gro C. C.; Flak, Marianne Møretrø; Gerstner, Thorsten; Sundberg, Cato; Lerdal, Bjørn; Skranes, Jon

    2015-01-01

    This paper presents a new initiative in the South-Eastern Health Region of Norway to establish a regional resource center focusing on services for children and adolescents aged 2–18 years with prenatal exposure to alcohol or other drugs. In Norway, the prevalence of fetal alcohol spectrum (FAS) is not known but has been estimated to be between 1 and 2 children per 1000 births, while the prevalence of prenatal exposure to illicit drugs is unknown. The resource center is the first of its kind in Scandinavia and will have three main objectives: (1) provide hospital staff, community health and child welfare personnel, and special educators with information, educational courses, and seminars focused on the identification, diagnosis, and treatment of children with a history of prenatal alcohol/drug exposure; (2) provide specialized health services, such as diagnostic services and intervention planning, for children referred from hospitals in the South-Eastern Health Region of Norway; and (3) initiate multicenter studies focusing on the diagnostic process and evaluation of interventions. PMID:26692762

  6. Amarillo National Resource Center for plutonium. Work plan progress report, November 1, 1995--January 31, 1996

    SciTech Connect

    Cluff, D.

    1996-04-01

    The Center operates under a cooperative agreement between DOE and the State of Texas and is directed and administered by an education consortium. Its programs include developing peaceful uses for the materials removed from dismantled weapons, studying effects of nuclear materials on environment and public health, remedying contaminated soils and water, studying storage, disposition, and transport of Pu, HE, and other hazardous materials removed from weapons, providing research and counsel to US in carrying out weapons reductions in cooperation with Russia, and conducting a variety of education and training programs.

  7. The Radiation Safety Information Computational Center - A Resource for Training the Next Generation Engineer

    SciTech Connect

    Kirk, Bernadette Lugue

    2009-01-01

    RSICC came into existence in 1962 largely as a result of the report made by Alvin Weinbergand others to the Executive Office of the President of the United States on the 'information explosion' and the role of the technical community and government in its preservation and use. This report became known as the Weinberg Report. Its theme was 'Information is an integral part of science; without proper handling of information, science cannot function.' The report recommended the establishment of specialized information centers -'to digest and evaluate -to make condensations and reviews -thus saving the time of the individual research scientist and engineer.'

  8. [The evidences for formulation of schistosomiasis control and elimination criteria: results from a large scale of retrospective investigations].

    PubMed

    Zhou, Xiao-Nong; Wang, Tian-Ping; Lin, Dan-Dan; Wen, Li-Yong; Zhou, Bo; Xu, Jing; Li Shi-Zhu

    2014-10-01

    In this study, we summarized the results from the retrospective investigation on endemic situation of schistosomiasis that was implemented in nine provinces (autonomous region), China in 2009, demonstrated the role of these retrospective investigations in accelerating the progress of schistosomiasis control in China, and clarified the great significance of the investigation for summarizing the experiences for the control of schistosomiasis, and analyzing the changing patterns and affecting factors of endemic status of schistosomiasis in China. In addition, these retrospective investigations provide reliable evidence for revising the Criteria of Schistosomiasis Control and Elimination, and for the more accurate and scientific assessment of the effectiveness of schistosomiasis control in China.

  9. Engaging Community Stakeholders to Evaluate the Design, Usability, and Acceptability of a Chronic Obstructive Pulmonary Disease Social Media Resource Center

    PubMed Central

    Chaney, Beth; Chaney, Don; Paige, Samantha; Payne-Purvis, Caroline; Tennant, Bethany; Walsh-Childers, Kim; Sriram, PS; Alber, Julia

    2015-01-01

    Background Patients with chronic obstructive pulmonary disease (COPD) often report inadequate access to comprehensive patient education resources. Objective The purpose of this study was to incorporate community-engagement principles within a mixed-method research design to evaluate the usability and acceptability of a self-tailored social media resource center for medically underserved patients with COPD. Methods A multiphase sequential design (qual → QUANT → quant + QUAL) was incorporated into the current study, whereby a small-scale qualitative (qual) study informed the design of a social media website prototype that was tested with patients during a computer-based usability study (QUANT). To identify usability violations and determine whether or not patients found the website prototype acceptable for use, each patient was asked to complete an 18-item website usability and acceptability questionnaire, as well as a retrospective, in-depth, semistructured interview (quant + QUAL). Results The majority of medically underserved patients with COPD (n=8, mean 56 years, SD 7) found the social media website prototype to be easy to navigate and relevant to their self-management information needs. Mean responses on the 18-item website usability and acceptability questionnaire were very high on a scale of 1 (strongly disagree) to 5 (strongly agree) (mean 4.72, SD 0.33). However, the majority of patients identified several usability violations related to the prototype’s information design, interactive capabilities, and navigational structure. Specifically, 6 out of 8 (75%) patients struggled to create a log-in account to access the prototype, and 7 out of 8 patients (88%) experienced difficulty posting and replying to comments on an interactive discussion forum. Conclusions Patient perceptions of most social media website prototype features (eg, clickable picture-based screenshots of videos, comment tools) were largely positive. Mixed-method stakeholder feedback was

  10. Solar Technology Acceleration Center (SolarTAC): Solar Resource & Meteorological Assessment Project (SOLRMAP); Aurora, Colorado (Data)

    DOE Data Explorer

    Wilcox, S.; Andreas, A.

    2011-02-11

    Located in Colorado, near Denver International Airport, SolarTAC is a private, member-based, 74-acre outdoor facility where the solar industry tests, validates, and demonstrates advanced solar technologies. SolarTAC was launched in 2008 by a public-private consortium, including Midwest Research Institute (MRI). As a supporting member of SolarTAC, the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) has established a high quality solar and meteorological measurement station at this location. This Solar Resource and Meteorological Assessment Project (SOLRMAP) provides high quality measurements to support deployment of power projects in the United States. The no-funds-exchanged collaboration brings NREL solar resource assessment expertise together with industry needs for measurements. The end result is high quality data sets to support the financing, design, and monitoring of large scale solar power projects for industry in addition to research-quality data for NREL model development. NREL provides consultation for instrumentation and station deployment, along with instrument calibrations, data acquisition, quality assessment, data distribution, and summary reports. Industry participants provide equipment, infrastructure, and station maintenance.

  11. [Epidemic characteristics and security implications of Africa schistosomiasis on people who go to Africa].

    PubMed

    Pan, Xiang; Zhou, Yi-biao; Yang, Ya; Song, Xiu-xia; Jiang, Qing-wu

    2015-08-01

    With the economic globalization, and the economic and trade cooperation and cultural communication between China and African countries, more and more Chinese people go to Africa for work or travel. However, there is a quick increase of imported schistosomiasis patients who return from Africa. This paper analyzes the security implications of epidemic characteristics of Africa schistosomiasis on the people who go to Africa, and put forward several suggestions to help them to prevent from schistosomiasis. PMID:26767275

  12. [Epidemic characteristics and security implications of Africa schistosomiasis on people who go to Africa].

    PubMed

    Pan, Xiang; Zhou, Yi-biao; Yang, Ya; Song, Xiu-xia; Jiang, Qing-wu

    2015-08-01

    With the economic globalization, and the economic and trade cooperation and cultural communication between China and African countries, more and more Chinese people go to Africa for work or travel. However, there is a quick increase of imported schistosomiasis patients who return from Africa. This paper analyzes the security implications of epidemic characteristics of Africa schistosomiasis on the people who go to Africa, and put forward several suggestions to help them to prevent from schistosomiasis.

  13. Spatiotemporal Patterns of Schistosomiasis-Related Deaths, Brazil, 2000–2011

    PubMed Central

    Martins-Melo, Francisco Rogerlândio; Pinheiro, Marta Cristhiany Cunha; Ramos, Alberto Novaes; Alencar, Carlos Henrique; Bezerra, Fernando Schemelzer de Moraes

    2015-01-01

    We analyzed spatiotemporal patterns of 8,756 schistosomiasis-related deaths in Brazil during 2000–2011 and identified high-risk clusters of deaths, mainly in highly schistosomiasis-endemic areas along the coast of Brazil’s Northeast Region. Schistosomiasis remains a neglected public health problem with a high number of deaths in disease-endemic and emerging focal areas. PMID:26401716

  14. NATIONAL CARTOGRAPHIC INFORMATION CENTER: AN INFORMATION RESOURCE ON MAPPING PRODUCTS FOR THE NATION.

    USGS Publications Warehouse

    Stevens, Alan R.

    1985-01-01

    Since its inception in 1974 the National Cartographic Information Center (NCIC), US Geological Survey, has rapidly developed to become a focal point for providing information on the availability of cartographic data, including maps/charts, aerial photographs, satellite imagery, geodetic control, digital mapping data, map materials and related cartographic products. In early years NCIC concentrated its efforts on encoding and entering several major National Mapping Division record collections into its systems. NCIC is now stressing the acquisition of data from sources outside the National Mapping Division, including 37 Federal agencies and more than a thousand State and private institutions. A critical review has recently been conducted by NCIC of its systems with the aim of improving its efficiency and levels of operation. Several activities which resulted include improving its existing networks, refinement of digital data distribution, study of new storage media and related projects.

  15. Fiscal year 1986 program report: Rhode Island Water Resources Research Center

    SciTech Connect

    Poon, C.P.C.

    1987-07-01

    Water resources projects included a detailed partitioning of nitrogen in soil solution, turf clipping, and soil organic for various fertilizer rates; a better method of managing lawn turf to minimize nitrate contamination of ground water was found. Extensive studies showed chloride concentration for river baseflows in Rhode Island lower than the current EPA standards and advisory limits. Both road density and the subsoil layer under the highway in swamp areas were found to affect the chloride concentration. A numerical model of two-phase (gasoline/groundwater) immiscible fluid flow through soil was developed to predict gasoline movement in aquifer and for optimizing the pumping rates in a clean-up process. Effects of alum coagulant dosage, mixing intensity, and mixing time on direct water filtration performance and its optimization in sand filters were investigated.

  16. Fort Collins Science Center Ecosystem Dynamics branch--interdisciplinary research for addressing complex natural resource issues across landscapes and time

    USGS Publications Warehouse

    Bowen, Zachary H.; Melcher, Cynthia P.; Wilson, Juliette T.

    2013-01-01

    The Ecosystem Dynamics Branch of the Fort Collins Science Center offers an interdisciplinary team of talented and creative scientists with expertise in biology, botany, ecology, geology, biogeochemistry, physical sciences, geographic information systems, and remote-sensing, for tackling complex questions about natural resources. As demand for natural resources increases, the issues facing natural resource managers, planners, policy makers, industry, and private landowners are increasing in spatial and temporal scope, often involving entire regions, multiple jurisdictions, and long timeframes. Needs for addressing these issues include (1) a better understanding of biotic and abiotic ecosystem components and their complex interactions; (2) the ability to easily monitor, assess, and visualize the spatially complex movements of animals, plants, water, and elements across highly variable landscapes; and (3) the techniques for accurately predicting both immediate and long-term responses of system components to natural and human-caused change. The overall objectives of our research are to provide the knowledge, tools, and techniques needed by the U.S. Department of the Interior, state agencies, and other stakeholders in their endeavors to meet the demand for natural resources while conserving biodiversity and ecosystem services. Ecosystem Dynamics scientists use field and laboratory research, data assimilation, and ecological modeling to understand ecosystem patterns, trends, and mechanistic processes. This information is used to predict the outcomes of changes imposed on species, habitats, landscapes, and climate across spatiotemporal scales. The products we develop include conceptual models to illustrate system structure and processes; regional baseline and integrated assessments; predictive spatial and mathematical models; literature syntheses; and frameworks or protocols for improved ecosystem monitoring, adaptive management, and program evaluation. The descriptions

  17. Final Report: Phase II Nevada Water Resources Data, Modeling, and Visualization (DMV) Center

    SciTech Connect

    Jackman, Thomas; Minor, Timothy; Pohll, Gregory

    2013-07-22

    Water is unquestionably a critical resource throughout the United States. In the semi-arid west -- an area stressed by increase in human population and sprawl of the built environment -- water is the most important limiting resource. Crucially, science must understand factors that affect availability and distribution of water. To sustain growing consumptive demand, science needs to translate understanding into reliable and robust predictions of availability under weather conditions that could be average but might be extreme. These predictions are needed to support current and long-term planning. Similar to the role of weather forecast and climate prediction, water prediction over short and long temporal scales can contribute to resource strategy, governmental policy and municipal infrastructure decisions, which are arguably tied to the natural variability and unnatural change to climate. Change in seasonal and annual temperature, precipitation, snowmelt, and runoff affect the distribution of water over large temporal and spatial scales, which impact the risk of flooding and the groundwater recharge. Anthropogenic influences and impacts increase the complexity and urgency of the challenge. The goal of this project has been to develop a decision support framework of data acquisition, digital modeling, and 3D visualization. This integrated framework consists of tools for compiling, discovering and projecting our understanding of processes that control the availability and distribution of water. The framework is intended to support the analysis of the complex interactions between processes that affect water supply, from controlled availability to either scarcity or deluge. The developed framework enables DRI to promote excellence in water resource management, particularly within the Lake Tahoe basin. In principle, this framework could be replicated for other watersheds throughout the United States. Phase II of this project builds upon the research conducted during

  18. Iowa State University's undergraduate minor, online graduate certificate and resource center in NDE

    NASA Astrophysics Data System (ADS)

    Bowler, Nicola; Larson, Brian F.; Gray, Joseph N.

    2014-02-01

    Nondestructive evaluation is a `niche' subject that is not yet offered as an undergraduate or graduate major in the United States. The undergraduate minor in NDE offered within the College of Engineering at Iowa State University (ISU) provides a unique opportunity for undergraduate aspiring engineers to obtain a qualification in the multi-disciplinary subject of NDE. The minor requires 16 credits of course work within which a core course and laboratory in NDE are compulsory. The industrial sponsors of Iowa State's Center for Nondestructive Evaluation, and others, strongly support the NDE minor and actively recruit students from this pool. Since 2007 the program has graduated 10 students per year and enrollment is rising. In 2011, ISU's College of Engineering established an online graduate certificate in NDE, accessible not only to campus-based students but also to practicing engineers via the web. The certificate teaches the fundamentals of three major NDE techniques; eddy-current, ultrasonic and X-ray methods. This paper describes the structure of these programs and plans for development of an online, coursework-only, Master of Engineering in NDE and thesis-based Master of Science degrees in NDE.

  19. Grant writing for childbirth educators: lessons learned from the resource center for young parents-to-be.

    PubMed

    Broussard, Brenda S; Broussard, Anne B

    2010-01-01

    Obtaining funding to support community-based childbirth education programs can be a challenge for childbirth educators who may have little grant-writing experience. This article was written by two nurse educators/nurse-midwives who have been involved for over 10 years with a grant-funded parenting and childbirth education program for pregnant teens. It reviews the background of the Resource Center for Young Parents-To-Be, suggests grant-funding sources, and explains the building of partnerships in the community. The basic steps involved in the grant-writing process are presented as well as the importance of follow-up evaluations and reports. Grant-writing skills and the ability to forge partnerships with other community organizations can be important tools for childbirth educators and health-care professionals. PMID:21197129

  20. The American Dental Association's Center for Evidence-Based Dentistry: a critical resource for 21st century dental practice.

    PubMed

    Frantsve-Hawley, Julie; Jeske, Arthur

    2011-02-01

    Through its website (http:// www.ada.org/prof/resources/ebd/index.asp), the American Dental Association's Center for Evidence-Based Dentistry offers dental health professionals access to systematic reviews of oral health-related research findings, as well as Clinical Recommendations, which summarize large bodies of scientific evidence in the form of practice recommendations, e.g., the use of professionally-applied topical fluoride and pit-and-fissure sealants. Another feature of the site of great practical importance to the practicing dentist is the Critical Summary, which is a concise review of an individual systematic review's methodology and findings, as well as the importance and context of the outcomes, and the strengths and weaknesses of the systematic review and its implications for dental practice.

  1. Spatio-Temporal Patterns of Schistosomiasis Japonica in Lake and Marshland Areas in China: The Effect of Snail Habitats

    PubMed Central

    Hu, Yi; Gao, Jie; Chi, Meina; Luo, Can; Lynn, Henry; Sun, Liqian; Tao, Bo; Wang, Decheng; Zhang, Zhijie; Jiang, Qingwu

    2014-01-01

    The progress of the integrated control policy for schistosomiasis implemented since 2005 in China, which is aiming at reducing the roles of bovines and humans as infection sources, may be challenged by persistent presence of infected snails in lake and marshland areas. Based on annual parasitologic data for schistosomiasis during 2004–2011 in Xingzi County, a spatio-temporal kriging model was used to investigate the spatio-temporal pattern of schistosomiasis risk. Results showed that environmental factors related to snail habitats can explain the spatio-temporal variation of schistosomiasis. Predictive maps of schistosomiasis risk illustrated that clusters of the disease fluctuated during 2004–2008; there was an extensive outbreak in 2008 and attenuated disease occurrences afterwards. An area with an annually constant cluster of schistosomiasis was identified. Our study suggests that targeting snail habitats located within high-risk areas for schistosomiasis would be an economic and sustainable way of schistosomiasis control in the future. PMID:24980498

  2. Spatio-temporal patterns of schistosomiasis japonica in lake and marshland areas in China: the effect of snail habitats.

    PubMed

    Hu, Yi; Gao, Jie; Chi, Meina; Luo, Can; Lynn, Henry; Sun, Liqian; Tao, Bo; Wang, Decheng; Zhang, Zhijie; Jiang, Qingwu

    2014-09-01

    The progress of the integrated control policy for schistosomiasis implemented since 2005 in China, which is aiming at reducing the roles of bovines and humans as infection sources, may be challenged by persistent presence of infected snails in lake and marshland areas. Based on annual parasitologic data for schistosomiasis during 2004-2011 in Xingzi County, a spatio-temporal kriging model was used to investigate the spatio-temporal pattern of schistosomiasis risk. Results showed that environmental factors related to snail habitats can explain the spatio-temporal variation of schistosomiasis. Predictive maps of schistosomiasis risk illustrated that clusters of the disease fluctuated during 2004-2008; there was an extensive outbreak in 2008 and attenuated disease occurrences afterwards. An area with an annually constant cluster of schistosomiasis was identified. Our study suggests that targeting snail habitats located within high-risk areas for schistosomiasis would be an economic and sustainable way of schistosomiasis control in the future.

  3. Screening Genetic Resources of Capsicum Peppers in Their Primary Center of Diversity in Bolivia and Peru.

    PubMed

    van Zonneveld, Maarten; Ramirez, Marleni; Williams, David E; Petz, Michael; Meckelmann, Sven; Avila, Teresa; Bejarano, Carlos; Ríos, Llermé; Peña, Karla; Jäger, Matthias; Libreros, Dimary; Amaya, Karen; Scheldeman, Xavier

    2015-01-01

    For most crops, like Capsicum, their diversity remains under-researched for traits of interest for food, nutrition and other purposes. A small investment in screening this diversity for a wide range of traits is likely to reveal many traditional varieties with distinguished values. One objective of this study was to demonstrate, with Capsicum as model crop, the application of indicators of phenotypic and geographic diversity as effective criteria for selecting promising genebank accessions for multiple uses from crop centers of diversity. A second objective was to evaluate the expression of biochemical and agromorphological properties of the selected Capsicum accessions in different conditions. Four steps were involved: 1) Develop the necessary diversity by expanding genebank collections in Bolivia and Peru; 2) Establish representative subsets of ~100 accessions for biochemical screening of Capsicum fruits; 3) Select promising accessions for different uses after screening; and 4) Examine how these promising accessions express biochemical and agromorphological properties when grown in different environmental conditions. The Peruvian Capsicum collection now contains 712 accessions encompassing all five domesticated species (C. annuum, C. chinense, C. frutescens, C. baccatum, and C. pubescens). The collection in Bolivia now contains 487 accessions, representing all five domesticates plus four wild taxa (C. baccatum var. baccatum, C. caballeroi, C. cardenasii, and C. eximium). Following the biochemical screening, 44 Bolivian and 39 Peruvian accessions were selected as promising, representing wide variation in levels of antioxidant capacity, capsaicinoids, fat, flavonoids, polyphenols, quercetins, tocopherols, and color. In Peru, 23 promising accessions performed well in different environments, while each of the promising Bolivian accessions only performed well in a certain environment. Differences in Capsicum diversity and local contexts led to distinct outcomes in

  4. Screening Genetic Resources of Capsicum Peppers in Their Primary Center of Diversity in Bolivia and Peru.

    PubMed

    van Zonneveld, Maarten; Ramirez, Marleni; Williams, David E; Petz, Michael; Meckelmann, Sven; Avila, Teresa; Bejarano, Carlos; Ríos, Llermé; Peña, Karla; Jäger, Matthias; Libreros, Dimary; Amaya, Karen; Scheldeman, Xavier

    2015-01-01

    For most crops, like Capsicum, their diversity remains under-researched for traits of interest for food, nutrition and other purposes. A small investment in screening this diversity for a wide range of traits is likely to reveal many traditional varieties with distinguished values. One objective of this study was to demonstrate, with Capsicum as model crop, the application of indicators of phenotypic and geographic diversity as effective criteria for selecting promising genebank accessions for multiple uses from crop centers of diversity. A second objective was to evaluate the expression of biochemical and agromorphological properties of the selected Capsicum accessions in different conditions. Four steps were involved: 1) Develop the necessary diversity by expanding genebank collections in Bolivia and Peru; 2) Establish representative subsets of ~100 accessions for biochemical screening of Capsicum fruits; 3) Select promising accessions for different uses after screening; and 4) Examine how these promising accessions express biochemical and agromorphological properties when grown in different environmental conditions. The Peruvian Capsicum collection now contains 712 accessions encompassing all five domesticated species (C. annuum, C. chinense, C. frutescens, C. baccatum, and C. pubescens). The collection in Bolivia now contains 487 accessions, representing all five domesticates plus four wild taxa (C. baccatum var. baccatum, C. caballeroi, C. cardenasii, and C. eximium). Following the biochemical screening, 44 Bolivian and 39 Peruvian accessions were selected as promising, representing wide variation in levels of antioxidant capacity, capsaicinoids, fat, flavonoids, polyphenols, quercetins, tocopherols, and color. In Peru, 23 promising accessions performed well in different environments, while each of the promising Bolivian accessions only performed well in a certain environment. Differences in Capsicum diversity and local contexts led to distinct outcomes in

  5. Screening Genetic Resources of Capsicum Peppers in Their Primary Center of Diversity in Bolivia and Peru

    PubMed Central

    van Zonneveld, Maarten; Ramirez, Marleni; Williams, David E.; Petz, Michael; Meckelmann, Sven; Avila, Teresa; Bejarano, Carlos; Peña, Karla; Jäger, Matthias; Libreros, Dimary; Amaya, Karen; Scheldeman, Xavier

    2015-01-01

    For most crops, like Capsicum, their diversity remains under-researched for traits of interest for food, nutrition and other purposes. A small investment in screening this diversity for a wide range of traits is likely to reveal many traditional varieties with distinguished values. One objective of this study was to demonstrate, with Capsicum as model crop, the application of indicators of phenotypic and geographic diversity as effective criteria for selecting promising genebank accessions for multiple uses from crop centers of diversity. A second objective was to evaluate the expression of biochemical and agromorphological properties of the selected Capsicum accessions in different conditions. Four steps were involved: 1) Develop the necessary diversity by expanding genebank collections in Bolivia and Peru; 2) Establish representative subsets of ~100 accessions for biochemical screening of Capsicum fruits; 3) Select promising accessions for different uses after screening; and 4) Examine how these promising accessions express biochemical and agromorphological properties when grown in different environmental conditions. The Peruvian Capsicum collection now contains 712 accessions encompassing all five domesticated species (C. annuum, C. chinense, C. frutescens, C. baccatum, and C. pubescens). The collection in Bolivia now contains 487 accessions, representing all five domesticates plus four wild taxa (C. baccatum var. baccatum, C. caballeroi, C. cardenasii, and C. eximium). Following the biochemical screening, 44 Bolivian and 39 Peruvian accessions were selected as promising, representing wide variation in levels of antioxidant capacity, capsaicinoids, fat, flavonoids, polyphenols, quercetins, tocopherols, and color. In Peru, 23 promising accessions performed well in different environments, while each of the promising Bolivian accessions only performed well in a certain environment. Differences in Capsicum diversity and local contexts led to distinct outcomes in

  6. A Summary of NASA Summer Faculty Fellowship Work in the E.O. Office and in the Educator Resources Center

    NASA Technical Reports Server (NTRS)

    Thompson, H. Wendell, Sr.

    2005-01-01

    The Office of Equal Opportunity supports a number of summer programs which are designed to: 1.) Increase the number of elementary and secondary students and teachers who are involved in NASA-related education opportunities; and 2.) Support higher education research capability and opportunities that attract and prepare increasing numbers of students and faculty for NASA-related careers. A part of my work in the E.O. office involved the evaluation of several of the programs in order to determine their level of success and to make recommendations for the improvement of those programs where necessary. As a part of the involvement with one of the programs, the PSTI, I had the great opportunity to interact with the students in a number of their sessions which involved problem-based learning in science, mathematics and technology. A summary of the evaluation of those programs is included in this report. The second part of my work involved assisting the coordinator of the Educator Resource Center at the Space and Rocket Center. I participated in space science workshops for in-service and pre-service teachers. There educational resources were made available to the participants including many hands-on activities that hey could take back to their classes. I participated in the three hour workshops that were offered on Tuesdays and Thursdays of each week, although there were workshops on other days. On Mondays, Wednesdays, and Fridays, I worked in the E.O. office. As a result of my work in the ERC, I developed a Directed Reading PowerPoint Lesson Plan Guide involving remote sensing entitled, Echo the Bat. This was based on a NASA published children's book entitled Echo The Bat, written by Ginger Butcher. I have included a description of the lesson in this report. A summary of the evaluations of several of the summer programs supported by the Equal Opportunity office are included in this report.

  7. Splenectomy Improves Hemostatic and Liver Functions in Hepatosplenic Schistosomiasis Mansoni

    PubMed Central

    Leite, Luiz Arthur Calheiros; Pimenta Filho, Adenor Almeida; Ferreira, Rita de Cássia dos Santos; da Fonseca, Caíque Silveira Martins; dos Santos, Bianka Santana; Montenegro, Silvia Maria Lucena; Lopes, Edmundo Pessoa de Almeida; Domingues, Ana Lúcia Coutinho; Owen, James Stuart; Lima, Vera Lucia de Menezes

    2015-01-01

    Background Schistosomiasis mansoni is a chronic liver disease, in which some patients (5–10%) progress to the most severe form, hepatosplenic schistosomiasis. This form is associated with portal hypertension and splenomegaly, and often episodes of gastrointestinal bleeding, even with liver function preserved. Splenectomy is a validated procedure to reduce portal hypertension following digestive bleeding. Here, we evaluate beneficial effects of splenectomy on blood coagulation factors and liver function tests in hepatosplenic schistosomiasis mansoni compared to non-operated patients. Methodology/Principal Findings Forty-five patients who had undergone splenectomy surgery were assessed by laboratory analyses and ultrasound examination and compared to a non-operated group (n = 55). Blood samples were obtained for liver function tests, platelet count and prothrombin time. Coagulation factors (II, VII, VIII, IX and X), protein C and antithrombin IIa, plasminogen activator inhibitor-1 were measured by routine photometric, chromogenic or enzyme-linked immunosorbent assays, while hyperfibrinolysis was defined by plasminogen activator inhibitor-1 levels. Both groups had similar age, gender and pattern of periportal fibrosis. Splenectomized patients showed significant reductions in portal vein diameter, alkaline phosphatase and bilirubin levels compared to non-operated patients, while for coagulation factors there were significant improvement in prothrombin, partial thromboplastin times and higher levels of factor VII, VIII, IX, X, protein C and plasminogen activator inhibitor-1. Conclusion/Significance This study shows that the decrease of flow pressure in portal circulation after splenectomy restores the capacity of hepatocyte synthesis, especially on the factor VII and protein C levels, and these findings suggest that portal hypertension in patients with hepatosplenic schistosomiasis influences liver functioning and the blood coagulation status. PMID:26267788

  8. U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center-Fiscal Year 2009 Annual Report

    USGS Publications Warehouse

    Nelson, Janice S.

    2010-01-01

    The Earth Resources Observation and Science (EROS) Center is a U.S. Geological Survey (USGS) facility focused on providing science and imagery to better understand our Earth. As part of the USGS Geography Discipline, EROS contributes to the Land Remote Sensing (LRS) Program, the Geographic Analysis and Monitoring (GAM) Program, and the National Geospatial Program (NGP), as well as our Federal partners and cooperators. The work of the Center is shaped by the Earth sciences, the missions of our stakeholders, and implemented through strong program and project management and application of state-of-the-art information technologies. Fundamentally, EROS contributes to the understanding of a changing Earth through 'research to operations' activities that include developing, implementing, and operating remote sensing based terrestrial monitoring capabilities needed to address interdisciplinary science and applications objectives at all levels-both nationally and internationally. The Center's programs and projects continually strive to meet and/or exceed the changing needs of the USGS, the Department of the Interior, our Nation, and international constituents. The Center's multidisciplinary staff uses their unique expertise in remote sensing science and technologies to conduct basic and applied research, data acquisition, systems engineering, information access and management, and archive preservation to address the Nation's most critical needs. Of particular note is the role of EROS as the primary provider of Landsat data, the longest comprehensive global land Earth observation record ever collected. This report is intended to provide an overview of the scientific and engineering achievements and illustrate the range and scope of the activities and accomplishments at EROS throughout fiscal year (FY) 2009. Additional information concerning the scientific, engineering, and operational achievements can be obtained from the scientific papers and other documents published by

  9. Service-aware resources integrated resilience for software defined data center networking based on IP over Flexi-Grid optical networks

    NASA Astrophysics Data System (ADS)

    Yang, Hui; Zhang, Jie; Zhao, Yongli; Cheng, Lei; Wu, Jialin; Ji, Yuefeng; Han, Jianrui; Lin, Yi; Lee, Young

    2015-01-01

    Due to the performance guarantee of low delay, huge bandwidth and high reliability at a low cost, IP over Flexi-Grid optical network is a very promising networking architecture applied to the interconnection of geographically distributed data centers. It can enable efficient resource utilization and support heterogeneous bandwidth demands in cost-effective, highly-available and energy-effective manner. In case of edge Flexi-Grid optical network node failure, to ensure a high-level quality of service (QoS) for user request after the failure becomes a research focus. In this paper, we propose a novel service-aware resources integrated resilience (SA-RIR) scheme for data center services in software defined data center networking architecture based on IP over Flexi-Grid optical networks. Different from previous works which restore the services just exploiting the optical stratum, the proposed scheme provides the resilience using the multiple stratums resources in case of the edge optical node failure. We quantitatively evaluate the feasibility and performances through the simulation under heavy traffic load scenario in terms of path blocking probability, path resilience latency and resource occupation rate with different failure rates. Simulation results show that, the SA-RIR scheme can enable joint optimization of IP network, Flexi-Grid optical network and data center application stratum resources, and enhance the data center service resilience responsiveness to the dynamic end-to-end demands.

  10. The research subject advocate at minority Clinical Research Centers: an added resource for protection of human subjects.

    PubMed

    Easa, David; Norris, Keith; Hammatt, Zoë; Kim, Kari; Hernandez, Esther; Kato, Kambrie; Balaraman, Venkataraman; Ho, Tammy; Shomaker, Samuel

    2005-01-01

    In early 2001, the National Institutes of Health (NIH) created the research subject advocate (RSA) position as an additional resource for human subjects protection at NIH-funded Clinical Research Centers (CRCs) to enhance the protection of human participants in clinical research studies. We describe the RSA position in the context of clinical research, with a particular emphasis on the role of the RSA in two of the five CRCs funded by the NIH Research Centers in Minority Institutions (RCMI) program. Through participation in protocol development, informed consent procedures, study implementation and follow-up with adverse events, the RSA works closely with research investigators and their staff to protect study participants. The RSA also conducts workshops, training and education sessions, and consultation with investigators to foster enhanced communication and adherence to ethical standards and safety regulations. Although we cannot yet provide substantive evidence of positive outcomes, this article illuminates the value of the RSA position in ensuring that safety of research participants is accorded the highest priority at CRCs. On the basis of initial results, we conclude that the RSA is an effective mechanism for achieving the NIH goal of maintaining the utmost scrutiny of protocols involving human subjects.

  11. Early lessons from schistosomiasis mass drug administration programs

    PubMed Central

    Secor, W. Evan

    2015-01-01

    Mass drug administration using praziquantel is the backbone of the current strategy for the control of schistosomiasis. As the theoretical plans have moved into practical application, certain challenges with this approach have surfaced, and it is likely that annual mass drug administration alone may not be sufficient to achieve program goals. However, mass drug administration is still the only available intervention that can be readily used in the wide variety of settings where schistosomiasis is endemic. The task then becomes how to improve this approach and identify what adjuncts to mass drug administration are effective, as programs move from morbidity control to elimination goals. Other aspects worthy of consideration include how best to employ new diagnostic tools to more easily identify where treatment is needed, and new formulations of praziquantel to extend the availability of treatment to all age groups. The aim of this review is to highlight both areas of challenge and of opportunity to improve the public health impact of schistosomiasis control programs. PMID:26937275

  12. Schistosomiasis in Egypt: A never-ending story?

    PubMed

    Othman, Ahmad A; Soliman, Rasha H

    2015-08-01

    Schistosomiasis has plagued the Egyptian population since the antiquity. The disease is still a public health problem in Egypt, despite the tendency of being overlooked. In the first part of this review, the past and current trends of schistosomiasis in Egypt are reviewed, including history, epidemiology, morbidity, therapy, and control of the disease. Most of these aspects are more or less relevant to other schistosome-endemic regions all over the world. As only one drug is currently available for individual treatment and preventive mass chemotherapy, the quest for complementary measures is urgently warranted. Indeed, one promising approach is the discovery of a vaccine. Herein, we point out the efforts of the Egyptian scientists to develop an efficacious and affordable vaccine against schistosomiasis - a step forward in the battle of elimination of Schistosoma infection. Based on the candidate vaccine antigens, four types of vaccine formulations are discussed: purified antigen vaccines, DNA constructs, attenuated cercariae, and excretory-secretory antigen vaccines. Finally, this review provides insights into this ancient seemingly long-lasting parasitic disease. PMID:25959770

  13. Potential impact of climate change on schistosomiasis transmission in China.

    PubMed

    Zhou, Xiao-Nong; Yang, Guo-Jing; Yang, Kun; Wang, Xian-Hong; Hong, Qing-Biao; Sun, Le-Ping; Malone, John B; Kristensen, Thomas K; Bergquist, N Robert; Utzinger, Jürg

    2008-02-01

    Appraisal of the present and future impact of climate change and climate variability on the transmission of infectious diseases is a complex but pressing public health issue. We developed a biology-driven model to assess the potential impact of rising temperature on the transmission of schistosomiasis in China. We found a temperature threshold of 15.4 degrees C for development of Schistosoma japonicum within the intermediate host snail (i.e., Oncomelania hupensis), and a temperature of 5.8 degrees C at which half the snail sample investigated was in hibernation. Historical data suggest that the occurrence of O. hupensis is restricted to areas where the mean January temperature is above 0 degrees C. The combination of these temperature thresholds, together with our own predicted temperature increases in China of 0.9 degrees C in 2030 and 1.6 degrees C in 2050 facilitated predictive risk mapping. We forecast an expansion of schistosomiasis transmission into currently non-endemic areas in the north, with an additional risk area of 783,883 km(2) by 2050, translating to 8.1% of the surface area of China. Our results call for rigorous monitoring and surveillance of schistosomiasis in a future warmer China. PMID:18256410

  14. Schistosomiasis in Egypt: A never-ending story?

    PubMed

    Othman, Ahmad A; Soliman, Rasha H

    2015-08-01

    Schistosomiasis has plagued the Egyptian population since the antiquity. The disease is still a public health problem in Egypt, despite the tendency of being overlooked. In the first part of this review, the past and current trends of schistosomiasis in Egypt are reviewed, including history, epidemiology, morbidity, therapy, and control of the disease. Most of these aspects are more or less relevant to other schistosome-endemic regions all over the world. As only one drug is currently available for individual treatment and preventive mass chemotherapy, the quest for complementary measures is urgently warranted. Indeed, one promising approach is the discovery of a vaccine. Herein, we point out the efforts of the Egyptian scientists to develop an efficacious and affordable vaccine against schistosomiasis - a step forward in the battle of elimination of Schistosoma infection. Based on the candidate vaccine antigens, four types of vaccine formulations are discussed: purified antigen vaccines, DNA constructs, attenuated cercariae, and excretory-secretory antigen vaccines. Finally, this review provides insights into this ancient seemingly long-lasting parasitic disease.

  15. Changing policy and practice in the control of pediatric schistosomiasis.

    PubMed

    Mutapi, Francisca

    2015-03-01

    Schistosomiasis is a chronic disease that affects ∼200 million people. The extended health impact of the disease has been estimated to exceed that of malaria or tuberculosis and to be nearer to that of HIV/AIDS. Within endemic areas, children carry the heaviest burden of infection. Infection/disease is controlled by the treatment of infected subjects with the anthelminthic drug praziquantel. Global initiatives from Partners of Parasite Control, including the World Health Organization (WHO), advocate regular school-based deworming strategies to reduce the development of severe morbidity, promote school-child health and development, and improve the cognitive potential of children. Until recently, preschool-aged children were excluded from schistosome treatment, creating a health inequity in affected populations. In 2010, the WHO updated their recommendations for the treatment of schistosomiasis in preschool-aged children (ie, children aged ≤5 years). This change was the culmination of several decades of research on schistosome epidemiology, immunology, and pathology in this age group. The recent development of a pediatric formulation of praziquantel (soon to enter clinical trials) should advance control efforts in preschool-aged children, with the goal of including these children in preventative chemotherapy (as currently occurs for soil-transmitted helminths). This review discusses the research work supporting the WHO revision of recommendations for treating preschool-aged children, as well as current barriers and knowledge gaps in pediatric schistosomiasis control.

  16. Transdermal evaporation delivery system of praziquantel for schistosomiasis japonicum chemotherapy.

    PubMed

    Wang, Lei; Zheng, Xinsheng; Fang, Yan; Wang, Yi; Duan, Cunzheng; Yao, Baoan

    2011-07-01

    A transdermal evaporation delivery system (TEDS) of praziquantel (PZQ) was developed by selecting ethylene glycol monophenyl ether as a nonvolatile component solvent and ethanol as a volatile component solvent to control efficiently the transmission and morbidity of the global schistosomiasis, providing a convenient administration system of PZQ for both humans and domestic animals. The solubility of PZQ in TEDS was more than 400 mg/mL when the ethanol concentration was 50% (w/w) in the solvent mixture at 32 °C, enabling to adapt requirements for the treatment of schistosomiasis. The highest serum drug concentration reached 35.93 µg/mL after transdermal administration of TEDS of PZQ in rabbits, being 6.3-fold higher than that after oral administration at the same dose. The TEDS of PZQ achieved treatment efficacy with the worm reduction of 100% when it was applied in the experimental treatment of Schistosoma japonicum in rabbits. The TEDS of PZQ that provides passive and nonocclusive delivery, having the inexpensive cost, low skin irritation rates, and precise dose of administration, should find application in the transmission control and chemotherapy of global schistosomiasis.

  17. Epidemiological features and control strategies of schistosomiasis japonica in China.

    PubMed

    Yuan, H C

    1993-08-01

    Schistosomiasis japonica in China has a long history and wide distribution. In the last three decades, great achievements have been obtained in schistosomiasis control. Among 12 formerly endemic provinces, municipalities, and autonomous regions, transmission has been successfully controlled in 2 provinces, 1 municipality and 1 autonomous region. Among 380 formerly endemic counties, transmission has been interrupted in 158 and is under control in 101. Most remaining endemic areas are located in marshlands, lake and mountainous regions. By the ecological and epidemiological features, the endemic areas in lake and mountainous regions can be classified into different categories. Infection is related to exposure to infected lake and ditch water. The inhabitant activities and level of education have much to do with the frequency of water contact. The density of the infected snail is the main index of determining the high-risk place in the mountain and lake regions, and livestock such as buffalo and pigs, the principal reservoir in the endemic areas. Properly arranged annual chemotherapy with praziquantel can reduce the prevalence rate of inhabitants and livestock. However, the prevalence rate can climb again rapidly. Therefore, a maintenance phase is urgently needed. Modification of the snail-ridden environment should be linked with agricultural development and construction of water conservancy. Surveillance should be strengthened in the area where schistosomiasis has been controlled.

  18. Spatio-temporal Transmission and Environmental Determinants of Schistosomiasis Japonica in Anhui Province, China

    PubMed Central

    Hu, Yi; Li, Rui; Bergquist, Robert; Lynn, Henry; Gao, Fenghua; Wang, Qizhi; Zhang, Shiqing; Sun, Liqian; Zhang, Zhijie; Jiang, Qingwu

    2015-01-01

    Background Schistosomiasis japonica still remains of public health and economic significance in China, especially in the lake and marshland areas along the Yangtze River Basin, where the control of transmission has proven difficult. In the study, we investigated spatio-temporal variations of S. japonicum infection risk in Anhui Province and assessed the associations of the disease with key environmental factors with the aim of understanding the mechanism of the disease and seeking clues to effective and sustainable schistosomiasis control. Methodology/Principal Findings Infection data of schistosomiasis from annual conventional surveys were obtained at the village level in Anhui Province, China, from 2000 to 2010 and used in combination with environmental data. The spatio-temporal kriging model was used to assess how these environmental factors affected the spatio-temporal pattern of schistosomiasis risk. Our results suggested that seasonal variation of the normalized difference vegetation index (NDVI), seasonal variation of land surface temperature at daytime (LSTD), and distance to the Yangtze River were negatively significantly associated with risk of schistosomiasis. Predictive maps showed that schistosomiasis prevalence remained at a low level and schistosomiasis risk mainly evolved along the Yangtze River. Schistosomiasis risk also followed a focal spatial pattern, fluctuating temporally with a peak (the largest spatial extent) in 2005 and then contracting gradually but with a scattered distribution until 2010. Conclusion The fitted spatio-temporal kriging model can capture variations of schistosomiasis risk over space and time. Combined with techniques of geographic information system (GIS) and remote sensing (RS), this approach facilitates and enriches risk modeling of schistosomiasis, which in turn helps to identify prior areas for effective and sustainable control of schistosomiasis in Anhui Province and perhaps elsewhere in China. PMID:25659112

  19. The EGI-Engage EPOS Competence Center - Interoperating heterogeneous AAI mechanisms and Orchestrating distributed computational resources

    NASA Astrophysics Data System (ADS)

    Bailo, Daniele; Scardaci, Diego; Spinuso, Alessandro; Sterzel, Mariusz; Schwichtenberg, Horst; Gemuend, Andre

    2016-04-01

    manage the use of the subsurface of the Earth. EPOS started its Implementation Phase in October 2015 and is now actively working in order to integrate multidisciplinary data into a single e-infrastructure. Multidisciplinary data are organized and governed by the Thematic Core Services (TCS) - European wide organizations and e-Infrastructure providing community specific data and data products - and are driven by various scientific communities encompassing a wide spectrum of Earth science disciplines. TCS data, data products and services will be integrated into the Integrated Core Services (ICS) system, that will ensure their interoperability and access to these services by the scientific community as well as other users within the society. The EPOS competence center (EPOS CC) goal is to tackle two of the main challenges that the ICS are going to face in the near future, by taking advantage of the technical solutions provided by EGI. In order to do this, we will present the two pilot use cases the EGI-EPOS CC is developing: 1) The AAI pilot, dealing with the provision of transparent and homogeneous access to the ICS infrastructure to users owning different kind of credentials (e.g. eduGain, OpenID Connect, X509 certificates etc.). Here the focus is on the mechanisms which allow the credential delegation. 2) The computational pilot, Improve the back-end services of an existing application in the field of Computational Seismology, developed in the context of the EC funded project VERCE. The application allows the processing and the comparison of data resulting from the simulation of seismic wave propagation following a real earthquake and real measurements recorded by seismographs. While the simulation data is produced directly by the users and stored in a Data Management System, the observations need to be pre-staged from institutional data-services, which are maintained by the community itself. This use case aims at exploiting the EGI FedCloud e-infrastructure for Data

  20. Geographic information systems as a tool for control program management for schistosomiasis in Egypt.

    PubMed

    Abdel-Rahman, M S; El-Bahy, M M; Malone, J B; Thompson, R A; El Bahy, N M

    2001-04-27

    During a 4-year study a geographic information system (GIS) risk model was constructed for predicting the relative risk of schistosomiasis in Kafr El-Sheikh governorate, Egypt. A 1-year 1990-1991 time series on diurnal temperature difference (dT) prepared from the advanced very high resolution radiometer (AVHRR) sensor on the NOAA-11 satellite was used to develop a regional risk model for the Nile delta based on thermal-hydrological domains. A May 15, 1990 Landsat TM scene (path 177, Row 38) was used to develop a local 'village-scale' environmental risk model based on higher resolution satellite sensor data (30 m picture element size at earth surface). Four of ten classes derived from a tasseled cap (Tcap) transformation of the Landsat TM scene were shown to be significantly related to a 5-year Schistosoma mansoni prevalence database from the Ministry of Health. A risk model was developed based on dT and the proportional area of the four Tcap classes in 5 km(2) buffer zones centered on rural health unit (RHU) reporting units. Available historical data on S. mansoni and its snail host Biomphalaria alexandrina, as well as recent field collected data were gathered and incorporated as separate themes. Model validation was done using data collected on snail population bionomics-infection rates, water quality, underground water table and cercariometry at 13 hydrologically representative sites. The role of soil type, water table and water quality was studied at 79 of 154 rural health unit sites. The model permitted retrieval of relevant data by RHU point location. For the first time in Egypt, the Kafr El-Sheikh GIS schistosoma prediction model can support MOH efforts to make more accurate control program decisions based on environmental predilection sites of endemic Schistosomiasis mansoni. PMID:11378141

  1. High rate of schistosomiasis in travelers after a brief exposure to the high-altitude Nyinambuga crater lake, Uganda.

    PubMed

    Lachish, Tamar; Tandlich, Moshik; Grossman, Tamar; Schwartz, Eli

    2013-11-01

    Travel-related schistosomiasis is usually associated with prolonged freshwater exposure. Until recently, Uganda's crater lakes were considered schistosomiasis free due to their high-altitude location. We describe an outbreak of acute schistosomiasis after a brief exposure (mean, 22 ± 9.5 minutes) to a high-altitude crater lake.

  2. Global assessment of schistosomiasis control over the past century shows targeting the snail intermediate host works best

    USGS Publications Warehouse

    Sokolow, Susanne H.; Wood, Chelsea L.; Jones, Isabel J.; Swartz, Scott J.; Lopez, Melina; Hsieh, Michael H.; Lafferty, Kevin D.; Kuris, Armand M.; Rickards, Chloe; De Leo, Giulio A.

    2016-01-01

    Snail control has been the most effective way to reduce schistosomiasis prevalence. Despite evidence that snail control leads to long-term disease reduction and elimination, most current schistosomiasis control efforts emphasize MDA using praziquantel over snail control. Combining drug-based control programs with affordable snail control seems the best strategy for eliminating schistosomiasis.

  3. A review of geographic information system and remote sensing with applications to the epidemiology and control of schistosomiasis in China.

    PubMed

    Yang, Guo-Jing; Vounatsou, Penelope; Zhou, Xiao-Nong; Utzinger, Jürg; Tanner, Marcel

    2005-01-01

    Geographic information system (GIS) and remote sensing (RS) technologies offer new opportunities for rapid assessment of endemic areas, provision of reliable estimates of populations at risk, prediction of disease distributions in areas that lack baseline data and are difficult to access, and guidance of intervention strategies, so that scarce resources can be allocated in a cost-effective manner. Here, we focus on the epidemiology and control of schistosomiasis in China and review GIS and RS applications to date. These include mapping prevalence and intensity data of Schistosoma japonicum at a large scale, and identifying and predicting suitable habitats for Oncomelania hupensis, the intermediate host snail of S. japonicum, at a small scale. Other prominent applications have been the prediction of infection risk due to ecological transformations, particularly those induced by floods and water resource developments, and the potential impact of climate change. We also discuss the limitations of the previous work, and outline potential new applications of GIS and RS techniques, namely quantitative GIS, WebGIS, and utilization of emerging satellite information, as they hold promise to further enhance infection risk mapping and disease prediction. Finally, we stress current research needs to overcome some of the remaining challenges of GIS and RS applications for schistosomiasis, so that further and sustained progress can be made to control this disease in China and elsewhere. PMID:16112638

  4. A review of geographic information system and remote sensing with applications to the epidemiology and control of schistosomiasis in China.

    PubMed

    Yang, Guo-Jing; Vounatsou, Penelope; Zhou, Xiao-Nong; Utzinger, Jürg; Tanner, Marcel

    2005-01-01

    Geographic information system (GIS) and remote sensing (RS) technologies offer new opportunities for rapid assessment of endemic areas, provision of reliable estimates of populations at risk, prediction of disease distributions in areas that lack baseline data and are difficult to access, and guidance of intervention strategies, so that scarce resources can be allocated in a cost-effective manner. Here, we focus on the epidemiology and control of schistosomiasis in China and review GIS and RS applications to date. These include mapping prevalence and intensity data of Schistosoma japonicum at a large scale, and identifying and predicting suitable habitats for Oncomelania hupensis, the intermediate host snail of S. japonicum, at a small scale. Other prominent applications have been the prediction of infection risk due to ecological transformations, particularly those induced by floods and water resource developments, and the potential impact of climate change. We also discuss the limitations of the previous work, and outline potential new applications of GIS and RS techniques, namely quantitative GIS, WebGIS, and utilization of emerging satellite information, as they hold promise to further enhance infection risk mapping and disease prediction. Finally, we stress current research needs to overcome some of the remaining challenges of GIS and RS applications for schistosomiasis, so that further and sustained progress can be made to control this disease in China and elsewhere.

  5. Spatial Analysis of Schistosomiasis in Hubei Province, China: A GIS-Based Analysis of Schistosomiasis from 2009 to 2013

    PubMed Central

    Chen, Yan-Yan; Huang, Xi-Bao; Xiao, Ying; Jiang, Yong; Shan, Xiao-wei; Zhang, Juan; Cai, Shun-Xiang; Liu, Jian-Bing

    2015-01-01

    Background Schistosomiasis remains a major public health problem in China. The major endemic areas are located in the lake and marshland regions of southern China, particularly in areas along the middle and low reach of the Yangtze River. Spatial analytical techniques are often used in epidemiology to identify spatial clusters in disease regions. This study assesses the spatial distribution of schistosomiasis and explores high-risk regions in Hubei Province, China to provide guidance on schistosomiasis control in marshland regions. Methods In this study, spatial autocorrelation methodologies, including global Moran’s I and local Getis–Ord statistics, were utilized to describe and map spatial clusters and areas where human Schistosoma japonicum infection is prevalent at the county level in Hubei province. In addition, linear logistic regression model was used to determine the characteristics of spatial autocorrelation with time. Results The infection rates of S. japonicum decreased from 2009 to 2013. The global autocorrelation analysis results on the infection rate of S. japonicum for five years showed statistical significance (Moran’s I > 0, P < 0.01), which suggested that spatial clusters were present in the distribution of S. japonicum infection from 2009 to 2013. Local autocorrelation analysis results showed that the number of highly aggregated areas ranged from eight to eleven within the five-year analysis period. The highly aggregated areas were mainly distributed in eight counties. Conclusions The spatial distribution of human S. japonicum infections did not exhibit a temporal change at the county level in Hubei Province. The risk factors that influence human S. japonicum transmission may not have changed after achieving the national criterion of infection control. The findings indicated that spatial–temporal surveillance of S. japonicum transmission plays a significant role on schistosomiasis control. Timely and integrated prevention should be

  6. The EGI-Engage EPOS Competence Center - Interoperating heterogeneous AAI mechanisms and Orchestrating distributed computational resources

    NASA Astrophysics Data System (ADS)

    Bailo, Daniele; Scardaci, Diego; Spinuso, Alessandro; Sterzel, Mariusz; Schwichtenberg, Horst; Gemuend, Andre

    2016-04-01

    manage the use of the subsurface of the Earth. EPOS started its Implementation Phase in October 2015 and is now actively working in order to integrate multidisciplinary data into a single e-infrastructure. Multidisciplinary data are organized and governed by the Thematic Core Services (TCS) - European wide organizations and e-Infrastructure providing community specific data and data products - and are driven by various scientific communities encompassing a wide spectrum of Earth science disciplines. TCS data, data products and services will be integrated into the Integrated Core Services (ICS) system, that will ensure their interoperability and access to these services by the scientific community as well as other users within the society. The EPOS competence center (EPOS CC) goal is to tackle two of the main challenges that the ICS are going to face in the near future, by taking advantage of the technical solutions provided by EGI. In order to do this, we will present the two pilot use cases the EGI-EPOS CC is developing: 1) The AAI pilot, dealing with the provision of transparent and homogeneous access to the ICS infrastructure to users owning different kind of credentials (e.g. eduGain, OpenID Connect, X509 certificates etc.). Here the focus is on the mechanisms which allow the credential delegation. 2) The computational pilot, Improve the back-end services of an existing application in the field of Computational Seismology, developed in the context of the EC funded project VERCE. The application allows the processing and the comparison of data resulting from the simulation of seismic wave propagation following a real earthquake and real measurements recorded by seismographs. While the simulation data is produced directly by the users and stored in a Data Management System, the observations need to be pre-staged from institutional data-services, which are maintained by the community itself. This use case aims at exploiting the EGI FedCloud e-infrastructure for Data

  7. [Schistosomiasis caused by Schistosoma mansoni in the Kou valley: Characterization of the transmission system and socioeconomic impact].

    PubMed

    Kpoda, Noëllie W; Sorgho, Herman; Poda, Jean-Noël; Ouédraogo, Jean Bosco; Kabré, Gustave B

    2013-01-01

    Schistosomiasis is one of the waterborne diseases which benefit from environmental and behavioral changes induced by the mobilization of surface water resources in Sahelian countries, such as Burkina Faso. Studies have established the existence of human schistosomiasis in the Kou valley, one of the oldest hydro-agricultural zones in the country. However, the role of population behavior in the transmission pattern of this disease and its socioeconomic impact in this valley are poorly understood. It is in response to these questions that this study was undertaken. The objectives of this study were to identify activities that exposed most of the Valley's population to infection by schistosomiasis, and to contribute knowledge on the consequences of this disease. The study was conducted in the cold dry season at the Kou Valley, located in the South Sudanese area of Burkina Faso. It has adopted the strategy of direct observation to examine host-parasites interactions. The study of the socioeconomic consequences of the infection has been first to identify subjects that actually carry the parasite by screening the population by the Kato-Katz method. These were then subjected to a questionnaire. Data were analyzed using Epi Info 6.4. This work has revealed six activities at risk of infection for the residents of the Valley with an increased risk of factor for rice farming, household activities and swimming. In view of these activities, women and young people seem to be most vulnerable to infection. This disease causes significant economic losses as a function of socio-professional categories of infected persons.

  8. Schistosomiasis mass drug administration in the Philippines: lessons learnt and the global implications.

    PubMed

    Inobaya, Marianette T; Olveda, Remigio M; Tallo, Veronica; McManus, Donald P; Williams, Gail M; Harn, Donald A; Li, Yuesheng; Chau, Thao N P; Olveda, David U; Ross, Allen G

    2015-01-01

    Schistosomiasis was first reported in the Philippines in 1906. A variety of treatments have been deployed to cure infection and to control the disease in the long-term. We discuss the journey to combat the disease in the Philippines and the lessons learnt which have implications for schistosomiasis control globally.

  9. Schistosomiasis mass drug administration in the Philippines: lessons learnt and the global implications.

    PubMed

    Inobaya, Marianette T; Olveda, Remigio M; Tallo, Veronica; McManus, Donald P; Williams, Gail M; Harn, Donald A; Li, Yuesheng; Chau, Thao N P; Olveda, David U; Ross, Allen G

    2015-01-01

    Schistosomiasis was first reported in the Philippines in 1906. A variety of treatments have been deployed to cure infection and to control the disease in the long-term. We discuss the journey to combat the disease in the Philippines and the lessons learnt which have implications for schistosomiasis control globally. PMID:25448635

  10. Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals.

    PubMed

    Mo, Annie X; Agosti, Jan M; Walson, Judd L; Hall, B Fenton; Gordon, Lance

    2014-01-01

    In March 2013, the National Institute of Allergy and Infectious Diseases and the Bill and Melinda Gates Foundation co-sponsored a meeting entitled "Schistosomiasis Elimination Strategy and Potential Role of a Vaccine in Achieving Global Health Goals" to discuss the potential role of schistosomiasis vaccines and other tools in the context of schistosomiasis control and elimination strategies. It was concluded that although schistosomiasis elimination in some focal areas may be achievable through current mass drug administration programs, global control and elimination will face several significant scientific and operational challenges, and will require an integrated approach with other, additional interventions. These challenges include vector (snail) control; environmental modification; water, sanitation, and hygiene; and other future innovative tools such as vaccines. Defining a clear product development plan that reflects a vaccine strategy as complementary to the existing control programs to combat different forms of schistosomiasis will be important to develop a vaccine effectively.

  11. [Application of Big Data Mining Technology in Monitoring and Early-warning of Schistosomiasis].

    PubMed

    Yang, Kun; Li, Shi-zhu

    2015-12-01

    The prevalence of schistosomiasis will soon be controlled to a low level in China. It is therefore imperative to establish a more sensitive and effective early warning system for schistosomiasis, so as to consolidate the achievements of the disease control. By covering four topics including the importance of early warning system for schistosomiasis and its research direction, as well as recent development in big data mining and its application in monitoring and early-warning of schistosomiasis, this review discusses the feasibility of data mining technology for monitoring and early warning of the disease. It is hoped that this technology would increase the efficacy of studies on monitoring and early warning, and promote the elimination of schistosomiasis in China.

  12. Transcatheter Closure of Atrial Septal Defects in a Center With Limited Resources: Outcomes and Short Term Follow-Up

    PubMed Central

    Putra, Sukman T.; Djer, Mulyadi M.; Idris, Nikmah S.; Samion, Hasri; Sastroasmoro, Sudigdo

    2015-01-01

    Background: Transcatheter closure of atrial septal defects (ASD) has been accepted world-wide as an alternative to surgical closure with excellent results. This interventional, non-surgical technique plays an important role in the treatment of ASD mostly in the developing world where resources are limited. Objectives: To report the outcomes and short term follow-up of transcatheter closure of ASD over a 12-year period at our institution with limited resources. Patients and Methods: This retrospective study included all patients with the diagnosis of secundum ASD and significant shunting (Qp/Qs > 1.5:1) as well as dilated right atrium and right ventricle who had transcatheter closure at Integrated Cardiovascular Center (PJT), Dr. Cipto Mangunkusumo Hospital between October 2002 and October 2014. One hundred fifty-two patients enrolled in this study were candidates for device closure. Right and left heart cardiac catheterization was performed before the procedure. All patients underwent physical examination, ECG, chest X-ray and transthoracal echocardiography (TTE) prior to device implantation. Results: A total of 152 patients with significant ASD underwent device implantation. Subjects’ age ranged from 0.63 to 69.6 years, with median 9.36 years and mean 16.30 years. They consisted of 33 (21.7%) males and 119 (78.3%) females, with mean body weight of 29.9 kg (range 8 to 75; SD 18.2). The device was successfully implanted in 150 patients where the majority of cases received the Amplatzer septal occluder (147/150; 98%) and the others received the Heart Lifetech ASD occluder (3/150, 2%), whereas two other cases were not suitable for device closure and we decided for surgical closure. The mean ASD size was 19.75 (range 14 - 25) mm. During the procedure, 5 (4.9%) patients had bradycardia and 3 (2.9%) patients had supraventricular tachycardia (SVT), all of which resolved. Conclusions: In our center with limited facilities and manpower, transcatheter closure of atrial

  13. Cultural resource survey report for construction of office building, driveway, and parking lot at the Stanford Linear Accelerator Center. Part 1

    SciTech Connect

    Perry, M.E.

    1995-01-01

    An Environmental Assessment and associated documentation is reported for the construction of an office building and parking lot in support of environmental management personnel activities. As part of the documentation process, the DOE determined that the proposed project constituted an undertaking as defined in Section 106 of the National Historic Preservation Act. In accordance with the regulations implementing Section 106 of the National Historic Preservation Act, a records and literature search and historic resource identification effort were carried out on behalf of the Stanford Linear Accelerator Center (SLAC). This report summarizes cultural resource literature and record searches and a historic resource identification effort.

  14. Teaching Sustainable Water Resources and Low Impact Development: A Project Centered Course for First-Year Undergraduates

    NASA Astrophysics Data System (ADS)

    Cianfrani, C. M.

    2009-12-01

    Teaching Sustainable Water Resources and Low Impact Development: A Project Centered Course for First-Year Undergraduates Christina M. Cianfrani Assistant Professor, School of Natural Science, Hampshire College, 893 West Avenue, Amherst, MA 01002 Sustainable water resources and low impact development principles are taught to first-year undergraduate students using an applied design project sited on campus. All students at Hampshire College are required to take at least one natural science course during their first year as part of their liberal arts education. This requirement is often met with resistance from non-science students. However, ‘sustainability’ has shown to be a popular topic on campus and ‘Sustainable Water Resources’ typically attracts ~25 students (a large class size for Hampshire College). Five second- or third-year students are accepted in the class as advanced students and serve as project leaders. The first-year students often enter the class with only basic high school science background. The class begins with an introduction to global water resources issues to provide a broad perspective. The students then analyze water budgets, both on a watershed basis and a personal daily-use basis. The students form groups of 4 to complete their semester project. Lectures on low impact design principles are combined with group work sessions for the second half of the semester. Students tour the physical site located across the street from campus and begin their project with a site analysis including soils, landcover and topography. They then develop a building plan and identify preventative and mitigative measures for dealing with stormwater. Each group completes TR-55 stormwater calculations for their design (pre- and post-development) to show the state regulations for quantity will be met with their design. Finally, they present their projects to the class and prepare a formal written report. The students have produced a wide variety of creative

  15. Human Resource Center Directory.

    ERIC Educational Resources Information Center

    Southwestern Cooperative Educational Lab., Albuquerque, NM.

    A reference bank of persons with expertise in educational, socioeconomic, and cultural matters as they relate to non-English speaking Spanish-surnamed adults has been compiled. Approximately 700 persons residing in 33 states, Washington, D.C., Puerto Rico, the Virgin Islands, and Italy are listed. A brief resume of each person listed includes…

  16. [Eradication of schistosomiasis: a new target and a new task for the National Schistosomiasis Control Porgramme in the People's Republic of China].

    PubMed

    Lei, Zheng-long; Zhou, Xiao-Nong

    2015-02-01

    The achievements for the national schistosomiasis control programme in the People's Republic of China over the last 6 decades were reviewed, with an emphasis on the status and challenges to accomplish the tasks of "Workplan for the Mid- and Long-term of National Schistosomiasis Control Programme from 2004 to 2015". Four features of current national schistosomiasis control programme were identified in the new stage. First, the high prevalence areas have been shrunk, but few regions are still at the risks of schitosomiasis rebounding. Second, large areas with low prevalence of schistosomiasis will remain for a long time, so that the disease surveillance will be a long-term task. Third, more notable places will be in the high risk areas where more activities of human and livestock occurred, so that it is essential to implement the integrated control measures in those high risk areas. Fourth, the technologies using in the schistosomiasis eradication programme are delayed as expected, and more needs to accelerate the R&D programmes. It was recommended that sustained implementation of integrated control strategy with more emphasis on control of infectious sources has to be strengthened through enhanced regulation performance in addition to the aforementioned notifications, in order to eradicate schistosomiasis in a response to the newly formulated target of "making the 'God of Plague' to be sweep away from the history, and retuning the clear land/water and happy/healthy life to the people".

  17. Evaluation of Four Career Education Media Used by the Indiana Career Resource Center. Research and Evaluation Report Series. Report Number 2: Career Education/Career Development Study.

    ERIC Educational Resources Information Center

    Carmichael, Margaret; And Others

    One hundred and sixteen elementary educators in Indiana were asked for their opinions of four primary and elementary level career education media available from the Indiana Career Resource Center. The media were: 1) Developing Understanding of Self and Others (DUSO), a program of activities including listening, experimental, inquiry, and…

  18. An Analysis of the Learning Resources Center Student and Faculty Surveys, Spring, 1977. Office of Institutional Research Report #78-1.

    ERIC Educational Resources Information Center

    Scott, Norman H.; Zabek, Robert J.

    In spring 1977, the faculty and students of Wytheville Community College were surveyed in regard to their attitudes toward and use of the Learning Resource Center (LRC). The student survey revealed that of 330 respondents, 46% used the library one hour or more per week; 63% of 129 respondents suggested a greater emphasis during orientation on…

  19. Auxiliary Services for High Schools' Bilingual Program Resource and Training Center: Project ASHS, 1988-89. Evaluation Section Report. OREA Report.

    ERIC Educational Resources Information Center

    Berney, Tomi D.; Hriskos, Constantine

    Project ASHS' Bilingual Resource and Training Center served 2,075 limited-English-proficient students, some of whom had limited ability to read and write in their native languages, at 15 sites. Most participants were older students returning to school to complete high school diploma requirements and prepare for the General Equivalency Diploma. The…

  20. Novel Therapeutic and Prevention Approaches for Schistosomiasis: Review

    PubMed Central

    El Ridi, Rashika A.F.; Tallima, Hatem A.-M.

    2012-01-01

    Schistosomiasis is a debilitating disease affecting approximately 600 million people in 74 developing countries, with 800 million, mostly children at risk. To circumvent the threat of having praziquantel (PZQ) as the only drug used for treatment, several PZQ derivatives were synthesized, and drugs destined for other parasites were used with success. A plethora of plant-derived oils and extracts were found to effectively kill juvenile and adult schistosomes, yet none was progressed to pre- and clinical studies except an oleo-gum resin extracted from the stem of Commiphora molmol, myrrh, which action was challenged in several trials. We have proposed an essential fatty acid, a component of our diet and cells, the polyunsaturated fatty acid arachidonic acid (ARA) as a remedy for schistosomiasis, due to its ability to activate the parasite tegument-bound neutral sphingomyelinase, with subsequent hydrolysis of the apical lipid bilayer sphingomyelin molecules, allowing access of specific antibody molecules, and eventual worm attrition. This concept was convincingly supported using larval and adult Schistosoma mansoni and Schistosoma haematobium worms in in vitro experiments, and in vivo studies in inbred mice and outbred hamsters. Even if ARA proves to be an entirely effective and safe therapy for schistosomiasis, it will not prevent reinfection, and accordingly, the need for developing an effective vaccine remains an urgent priority. Our studies have supported the status of S. mansoni calpain, glutathione-S-transferase, aldolase, triose phosphate isomerase, glyceraldehyde 3-phosphate dehydrogenase, enolase, and 2-cys peroxiredoxin as vaccine candidates, as they are larval excreted-secreted products and, contrary to the surface membrane molecules, are entirely accessible to the host immune system effector elements. We have proposed that the use of these molecules, in conjunction with Th2 cytokines-inducing adjuvants for recruiting and activating eosinophils and basophils

  1. Environmental inducers of schistosomiasis mansoni in Campinas, Brazil.

    PubMed

    Anaruma Filho, Francisco; Sant'Ana, João Moreno; dos Santos, Rozely Ferreira; Castagna, Cláudio Luiz

    2010-11-01

    Human occupation/activity in the suburbs of the large cities in Brazil, together with high social vulnerability associated with poor living conditions, influence the dynamics of schistosomiasis mansoni as well as several other emerging and re-emerging diseases. Previous notification data surveys for Campinas, São Paulo state, Brazil, carried out by the Information System for Notification Disease, show that there are distinct prevalence differences across healthcare districts of the city. This paper supports the hypothesis that the distribution of schistosomiasis is not random and that the centralized location of cases are linked to human behaviour, in particular to human activities that interfere with basic landscape structure. This paper analyzes the spatial patterns of the parasitic worm Schistosoma mansoni and its intermediate host Biomphalaria comparing disease prevalence with natural conditions and the current pattern of territory occupation by the population. The spatial and hierarchical distribution of factors related to the environmental conditions and land use that indicate the risk for schistosomiasis has been surveyed. It was found that landscape characteristics define the areas at risk for this endemic disease and, as a result, a risk map comprising different risk classes was established. This risk map highlights the regions prone to become new foci for infection or that serves to maintain an existing focus. The research approach used attempts to introduce "geotechnology", i.e. a social application in which better knowledge about these foci, designated endemic "hot spots" can assist preventive public intervention measures in a way that is inexpensive and easy to handle.

  2. Linking Satellite Remote Sensing Based Environmental Predictors to Disease: AN Application to the Spatiotemporal Modelling of Schistosomiasis in Ghana

    NASA Astrophysics Data System (ADS)

    Wrable, M.; Liss, A.; Kulinkina, A.; Koch, M.; Biritwum, N. K.; Ofosu, A.; Kosinski, K. C.; Gute, D. M.; Naumova, E. N.

    2016-06-01

    90% of the worldwide schistosomiasis burden falls on sub-Saharan Africa. Control efforts are often based on infrequent, small-scale health surveys, which are expensive and logistically difficult to conduct. Use of satellite imagery to predictively model infectious disease transmission has great potential for public health applications. Transmission of schistosomiasis requires specific environmental conditions to sustain freshwater snails, however has unknown seasonality, and is difficult to study due to a long lag between infection and clinical symptoms. To overcome this, we employed a comprehensive 8-year time-series built from remote sensing feeds. The purely environmental predictor variables: accumulated precipitation, land surface temperature, vegetative growth indices, and climate zones created from a novel climate regionalization technique, were regressed against 8 years of national surveillance data in Ghana. All data were aggregated temporally into monthly observations, and spatially at the level of administrative districts. The result of an initial mixed effects model had 41% explained variance overall. Stratification by climate zone brought the R2 as high as 50% for major zones and as high as 59% for minor zones. This can lead to a predictive risk model used to develop a decision support framework to design treatment schemes and direct scarce resources to areas with the highest risk of infection. This framework can be applied to diseases sensitive to climate or to locations where remote sensing would be better suited than health surveys.

  3. Prevention and control of schistosomiasis: a current perspective

    PubMed Central

    Inobaya, Marianette T; Olveda, Remigio M; Chau, Thao NP; Olveda, David U; Ross, Allen GP

    2014-01-01

    Schistosomiasis is a neglected tropical disease that ranks second only to malaria in terms of human suffering in the tropics and subtropics. Five species are known to infect man and there are currently over 240 million people infected worldwide. The cornerstone of control to date has been mass drug administration with 40 mg/kg of praziquantel but there are problems with this approach. Human and bovine vaccines are in various stages of development. Integrated control, targeting the life cycle, is the only approach that will lead to sustainability and future elimination. PMID:25400499

  4. Schistosomiasis vaccines: Farewell to the God of Plague?

    PubMed

    Taylor, M G

    1994-10-01

    Control and even eradication of schistosomiasis have been achieved in some countries using integrated measures but this disease remains endemic in 74 countries with 600 million at risk of whom 200 million are currently infected. The application of control measures, particularly population-based chemotherapy, has in many countries greatly reduced the incidence of serious disease manifestations, but vaccines are urgently needed to supplement existing control measures. Great advances are being made in vaccine development and the first clinical trials are expected to begin shortly. PMID:7932921

  5. Schistosomiasis mansoni presenting as a cerebellar tumor: case report.

    PubMed

    Silva, Joacil Carlos da; Lima, Frederico de Melo Tavares de; Vidal, Cláudio Henrique; Azevedo Filho, Hildo Cirne Rocha de

    2007-09-01

    The Manson's schistosomiasis tumoral form rarely affects the brain. There are only 12 cases prior related with a mean age of 25 years and a male predominance. We describe a 16-year-old Brazilian Northeastern boy with a cerebellar mass lesion. The radiological aspect was considered compatible with glioma and a gross total resection was performed. Microscopic examination disclosed intraparenchymal granulomas surrounding Schistosoma mansoni eggs. The case is compared with the literature findings and some peculiar aspects of this trematode infection are reviewed. PMID:17952294

  6. National Institute of Nursing Research Centers of Excellence: a logic model for sustainability, leveraging resources, and collaboration to accelerate cross-disciplinary science.

    PubMed

    Dorsey, Susan G; Schiffman, Rachel; Redeker, Nancy S; Heitkemper, Margaret; McCloskey, Donna Jo; Weglicki, Linda S; Grady, Patricia A

    2014-01-01

    The National Institute of Nursing Research (NINR) Centers of Excellence program is a catalyst enabling institutions to develop infrastructure and administrative support for creating cross-disciplinary teams that bring multiple strategies and expertise to bear on common areas of science. Centers are increasingly collaborative with campus partners and reflect an integrated team approach to advance science and promote the development of scientists in these areas. The purpose of this paper is to present the NINR Logic Model for Center Sustainability. The components of the logic model were derived from the presentations and robust discussions at the 2013 NINR center directors' meeting focused on best practices for leveraging resources and collaboration as methods to promote center sustainability. Collaboration through development and implementation of cross-disciplinary research teams is critical to accelerate the generation of new knowledge for solving fundamental health problems. Sustainability of centers as a long-term outcome beyond the initial funding can be enhanced by thoughtful planning of inputs, activities, and leveraging resources across multiple levels.

  7. Shifts in the Spatiotemporal Dynamics of Schistosomiasis: A Case Study in Anhui Province, China

    PubMed Central

    Chen, Yue; Gao, Fenghua; Wang, Qizhi; Zhang, Shiqing; Zhang, Zhijie; Jiang, Qingwu

    2015-01-01

    Background The Chinese national surveillance system showed that the risk of Schistosoma japonicum infection fluctuated temporally. This dynamical change might indicate periodicity of the disease, and its understanding could significantly improve targeted interventions to reduce the burden of schistosomiasis. The goal of this study was to investigate how the schistosomiasis risk varied temporally and spatially in recent years. Methodology/Principal Findings Parasitological data were obtained through repeated cross-sectional surveys that were carried out during 1997-2010 in Anhui Province, East China. A multivariate autoregressive model, combined with principal oscillation pattern (POP) analysis, was used to evaluate the spatio-temporal variation of schistosomiasis risk. Results showed that the temporal changes of schistosomiasis risk in the study area could be decomposed into two sustained damped oscillatory modes with estimated period of approximately 2.5 years. The POPs associated with these oscillatory components showed that the pattern near the Yangtze River varied markedly and that the disease risk appeared to evolve in a Southwest/Northeast orientation. The POP coefficients showed decreasing tendency until 2001, then increasing during 2002-2005 and decaying afterwards. Conclusion The POP analysis characterized the variations of schistosomiasis risk over space and time and demonstrated that the disease mainly varied temporally along the Yangtze River. The schistosomiasis risk declined periodically with a temporal fluctuation. Whether it resulted from previous national control strategies on schistosomiasis needs further investigations. PMID:25881189

  8. Have You Heard of Schistosomiasis? Knowledge, Attitudes and Practices in Nampula Province, Mozambique

    PubMed Central

    Rassi, Christian; Kajungu, Dan; Martin, Sandrine; Arroz, Jorge; Tallant, Jamie; Zegers de Beyl, Celine; Counihan, Helen; Newell, James N.; Phillips, Anna; Whitton, Jane; Muloliwa, Artur Manuel; Graham, Kirstie

    2016-01-01

    Background Schistosomiasis is a parasitic disease which affects almost 300 million people worldwide each year. It is highly endemic in Mozambique. Prevention and control of schistosomiasis relies mainly on mass drug administration (MDA), as well as adoption of basic sanitation practices. Individual and community perceptions of schistosomiasis are likely to have a significant effect on prevention and control efforts. In order to establish a baseline to evaluate a community engagement intervention with a focus on schistosomiasis, a survey to determine knowledge, attitudes and practices relating to the disease was conducted. Methodology/Principal Findings A representative cross-sectional household survey was carried out in four districts of Nampula province, Mozambique. Interviews were conducted in a total of 791 households, using a structured questionnaire. While awareness of schistosomiasis was high (91%), correct knowledge of how it is acquired (18%), transmitted (26%) and prevented (13%) was low among those who had heard of the disease. Misconceptions, such as the belief that schistosomiasis is transmitted through sexual contact (27%), were common. Only about a third of those who were aware of the disease stated that they practiced a protective behaviour and only a minority of those (39%) reported an effective behaviour. Despite several rounds of MDA for schistosomiasis in the recent past, only a small minority of households with children reported that at least one of them had received a drug to treat the disease (9%). Conclusion/Significance Poor knowledge of the causes of schistosomiasis and how to prevent it, coupled with persisting misconceptions, continue to pose barriers to effective disease prevention and control. To achieve high levels of uptake of MDA and adoption of protective behaviours, it will be essential to engage individuals and communities, improving their understanding of the causes and symptoms of schistosomiasis, recommended prevention

  9. Revitalizing an Urban Community College Women's Resource Center: Kingsborough Community College--The City University of New York.

    ERIC Educational Resources Information Center

    Miller, Estelle

    This article describes the creation, administration, and services of an urban community college women's center. Information is provided on the center's advisory board charged with broadening the base of support, advising on policy formation, long-term planning, and program development. Strategies utilized to promote the center (e.g., publications,…

  10. A Study of Mars Dust Environment Simulation at NASA Johnson Space Center Energy Systems Test Area Resource Conversion Test Facility

    NASA Technical Reports Server (NTRS)

    Chen, Yuan-Liang Albert

    1999-01-01

    The dust environment on Mars is planned to be simulated in a 20 foot thermal-vacuum chamber at the Johnson Space Center, Energy Systems Test Area Resource Conversion Test Facility in Houston, Texas. This vacuum chamber will be used to perform tests and study the interactions between the dust in Martian air and ISPP hardware. This project is to research, theorize, quantify, and document the Mars dust/wind environment needed for the 20 foot simulation chamber. This simulation work is to support the safety, endurance, and cost reduction of the hardware for the future missions. The Martian dust environment conditions is discussed. Two issues of Martian dust, (1) Dust Contamination related hazards, and (2) Dust Charging caused electrical hazards, are of our interest. The different methods of dust particles measurement are given. The design trade off and feasibility were studied. A glass bell jar system is used to evaluate various concepts for the Mars dust/wind environment simulation. It was observed that the external dust source injection is the best method to introduce the dust into the simulation system. The dust concentration of 30 Mg/M3 should be employed for preparing for the worst possible Martian atmosphere condition in the future. Two approaches thermal-panel shroud for the hardware conditioning are discussed. It is suggested the wind tunnel approach be used to study the dust charging characteristics then to be apply to the close-system cyclone approach. For the operation cost reduction purpose, a dehumidified ambient air could be used to replace the expensive CO2 mixture for some tests.

  11. Integrating Place-based Science and Data into Hydrology and Geoscience Education Using the CUAHSI Water Data Center Resources

    NASA Astrophysics Data System (ADS)

    Arrigo, J. S.; Dalbotten, D. M.; Hooper, R. P.; Pollak, J.; Geosling, E.

    2014-12-01

    "All water is local." For geoscientist researchers and educators, this simple statement underlies potentially powerful ways to engage students around hydrologic and engineering concepts. Education research has given us strong insight into how students learn. Place-based education gives students a personal and geographical context to connect concepts and processes to their everyday lives. Data-driven exercises build inquiry and critical thinking skills. With the ubiquity of water, the critical roles it plays in earth systems, and its influence on ecosystems, climate, geologic processes, economies, and human health, integrating water data and place-based exercises into the classroom is an excellent opportunity to enhance student learning and stimulate interest in the geosciences. THE CUAHSI Water Data Center (WDC), established in 2013, is the culmination of a decade of work to adapt modern web services technology to work on time-series data (such as a gage record or water-quality series), the most common water data type. It provides unprecedented consolidated access to water quantity and quality data across the US (and increasingly across the world). This allows educators to craft learning exercises around key concepts and locations, from rote problem sets to more exploratory investigations. The web services technology used address key limitations - such as difficulty in discovering data, co-locating data, and download options and access- that have been identified as barriers to integrating real data in classroom exercises. This presentation discusses key aspects of the system, provides example exercises, and discusses how we seek to engage the community to effectively chart a path forward for further development of both the technological and education resources.

  12. Schistosomiasis--a century searching for chemotherapeutic drugs.

    PubMed

    Ribeiro-dos-Santos, Gabriela; Verjovski-Almeida, Sergio; Leite, Luciana C C

    2006-10-01

    Schistosomiasis affects 200 million individuals in underdeveloped and developing regions and is a growing concern for travelers worldwide. There has been evidence of resistance to the praziquantel-based therapy and reports of acute-disease manifestation; therefore, other drugs affecting different stages of the schistosome parasites life cycle and alternative therapeutic regimens should be developed and become accessible. The present review results from a comprehensive search in the scientific literature for substances and compounds tested in the past centennial for schistosomiasis therapy. We gathered over 40 drugs providing information on therapeutic action in humans or animal model, toxicity, susceptible Schistosoma stages, species, etc. The drugs were grouped according to their known metabolic effects on the parasite, whether they are on membrane structure and function, carbohydrate metabolism, protein synthesis and function, or on nucleic acid metabolism. We discuss the current knowledge of drug-target interactions, their mechanism of action and possible therapy combinations. Furthermore, based in the literature and in our own experience with large-scale Schistosoma mansoni genome and transcriptome analyses, we put forward several recently described gene products that are promising target candidates for existing or new drugs. PMID:16636847

  13. [Endemic status of schistosomiasis in People's Republic of China in 2014].

    PubMed

    Lei, Zheng-long; Zhang, Li-juan; Xu, Zhi-min; Dang, Hui; Xu, Jing; Lv, Shan; Cao, Chun-li; Li, Shi-zhu; Zhou, Xiao-nong

    2015-12-01

    This report presented the endemic status of schistosomiasis in the People's Republic of China at national level in 2014, and analyzed the data captured from the national schistosomiasis prevention and control system and 81 national schistosomiasis surveillance sites. Among the 12 provinces (municipality and autonomous region) endemic for schistosomiasis japonica in China, 5 provinces (municipality and autonomous region) of Shanghai, Zhejiang, Fujian, Guangdong and Guangxi had achieved transmission interruption, 4 provinces of Sichuan, Yunnan, Jiangsu and Hubei had achieved transmission control, and Anhui, Jiangxi and Hunan provinces were still at infection control until 2014. There were 453 counties (city, district) endemic for schistosomiasis, with 251 million residents, and 30,048 villages endemic for schistosomiasis, with 68 million 507 thousand and 3 hundred residents. Among the 453 endemic counties (city, district), 69.09% (313/453) and 29.80% (135/ 453) endemic counties (city, district) reached the transmission interruption and transmission control respectively while the number of counties (city, district) at the stage of infection control reduced from 34 in 2013 to 5 in 2014 (accounted for 1.10% of the total number of endemic counties, 5/53). Till 2014, 115,614 people were estimated to have schistosomiasis and only 2 acute schistosomiasis cases were reported. In addition, there were 30,880 advanced schistosomiasis cases documented in 2014. In 2014, a total of 9,461,348 individuals received schistosomiasis examinations and 8,270 persons were found stool positives with the reduction rate of 50.96% as compared to that (16,865 cases) in 2013. The Oncomelania hupensis snail survey was performed in 20 123 endemic villages in 2014, and the snails were detected in 5,653 villages, which accounted for 28.09% of total villages, with 13 newly detected villages with snails. The snail survey covered an area of 576,506.37 hm² and snails were found in an area of 364 324

  14. [Endemic status of schistosomiasis in People's Republic of China in 2014].

    PubMed

    Lei, Zheng-long; Zhang, Li-juan; Xu, Zhi-min; Dang, Hui; Xu, Jing; Lv, Shan; Cao, Chun-li; Li, Shi-zhu; Zhou, Xiao-nong

    2015-12-01

    This report presented the endemic status of schistosomiasis in the People's Republic of China at national level in 2014, and analyzed the data captured from the national schistosomiasis prevention and control system and 81 national schistosomiasis surveillance sites. Among the 12 provinces (municipality and autonomous region) endemic for schistosomiasis japonica in China, 5 provinces (municipality and autonomous region) of Shanghai, Zhejiang, Fujian, Guangdong and Guangxi had achieved transmission interruption, 4 provinces of Sichuan, Yunnan, Jiangsu and Hubei had achieved transmission control, and Anhui, Jiangxi and Hunan provinces were still at infection control until 2014. There were 453 counties (city, district) endemic for schistosomiasis, with 251 million residents, and 30,048 villages endemic for schistosomiasis, with 68 million 507 thousand and 3 hundred residents. Among the 453 endemic counties (city, district), 69.09% (313/453) and 29.80% (135/ 453) endemic counties (city, district) reached the transmission interruption and transmission control respectively while the number of counties (city, district) at the stage of infection control reduced from 34 in 2013 to 5 in 2014 (accounted for 1.10% of the total number of endemic counties, 5/53). Till 2014, 115,614 people were estimated to have schistosomiasis and only 2 acute schistosomiasis cases were reported. In addition, there were 30,880 advanced schistosomiasis cases documented in 2014. In 2014, a total of 9,461,348 individuals received schistosomiasis examinations and 8,270 persons were found stool positives with the reduction rate of 50.96% as compared to that (16,865 cases) in 2013. The Oncomelania hupensis snail survey was performed in 20 123 endemic villages in 2014, and the snails were detected in 5,653 villages, which accounted for 28.09% of total villages, with 13 newly detected villages with snails. The snail survey covered an area of 576,506.37 hm² and snails were found in an area of 364 324

  15. Global Assessment of Schistosomiasis Control Over the Past Century Shows Targeting the Snail Intermediate Host Works Best

    PubMed Central

    Sokolow, Susanne H.; Wood, Chelsea L.; Jones, Isabel J.; Lopez, Melina; Lafferty, Kevin D.; Kuris, Armand M.; Rickards, Chloe; De Leo, Giulio A.

    2016-01-01

    Background Despite control efforts, human schistosomiasis remains prevalent throughout Africa, Asia, and South America. The global schistosomiasis burden has changed little since the new anthelmintic drug, praziquantel, promised widespread control. Methodology We evaluated large-scale schistosomiasis control attempts over the past century and across the globe by identifying factors that predict control program success: snail control (e.g., molluscicides or biological control), mass drug administrations (MDA) with praziquantel, or a combined strategy using both. For data, we compiled historical information on control tactics and their quantitative outcomes for all 83 countries and territories in which: (i) schistosomiasis was allegedly endemic during the 20th century, and (ii) schistosomiasis remains endemic, or (iii) schistosomiasis has been "eliminated," or is "no longer endemic," or transmission has been interrupted. Principal Findings Widespread snail control reduced prevalence by 92 ± 5% (N = 19) vs. 37 ± 7% (N = 29) for programs using little or no snail control. In addition, ecological, economic, and political factors contributed to schistosomiasis elimination. For instance, snail control was most common and widespread in wealthier countries and when control began earlier in the 20th century. Conclusions/Significance Snail control has been the most effective way to reduce schistosomiasis prevalence. Despite evidence that snail control leads to long-term disease reduction and elimination, most current schistosomiasis control efforts emphasize MDA using praziquantel over snail control. Combining drug-based control programs with affordable snail control seems the best strategy for eliminating schistosomiasis. PMID:27441556

  16. [Propagating the Culture of Schistosomiasis Control and Promoting Its Sustainable Development in China].

    PubMed

    Wu, Guan-ling

    2015-12-01

    Great achievements have been gained in schistosomiasis control in China due to the last half-century endeavor. These achievements not only indicate the success in disease control, but also represent a particularly successful social practice with a unique cultural property. Inspite of the accumulating reports on schistosomiasis prevention and control experience, there is a need to sublimate the experience to the "cultural" level, as historically the value of cultural and spiritual merits goes far beyond that of the achievements. Although the strategy and technology will be enriched with time, the cultural spirit remains especially important for the long- term promotion of schistosomiasis control. This paper materially dissected the meaning of "China's culture for schistosomiasis control", i.e., people-first, government-oriented, science-respected, collective wisdom and efforts, and diversity-embracing.

  17. Applications of Spatial Technology in Schistosomiasis Control Programme in The People's Republic of China.

    PubMed

    Wang, X-Y; He, J; Yang, K; Liang, S

    2016-01-01

    Schistosomiasis, as the important parasitic disease, has caused serious threats to human health globally. The People's Republic of China has acquired significant achievements based on large-scale interventions and innovational technology. The spatial technology was introduced in 1980s and widely used in the study and control of schistosomiasis in The People's Republic of China. This chapter reviews the progress and application of spatial technology in schistosomiasis control by analysing the spatiotemporal pattern of and the impact of ecological changes on schistosomiasis transmission, which have provided the information to design and select the control strategy, and assisted the establishment of the monitoring and early warning system in The People's Republic of China, especially in the marshland and mountainous regions. PMID:27137446

  18. [Propagating the Culture of Schistosomiasis Control and Promoting Its Sustainable Development in China].

    PubMed

    Wu, Guan-ling

    2015-12-01

    Great achievements have been gained in schistosomiasis control in China due to the last half-century endeavor. These achievements not only indicate the success in disease control, but also represent a particularly successful social practice with a unique cultural property. Inspite of the accumulating reports on schistosomiasis prevention and control experience, there is a need to sublimate the experience to the "cultural" level, as historically the value of cultural and spiritual merits goes far beyond that of the achievements. Although the strategy and technology will be enriched with time, the cultural spirit remains especially important for the long- term promotion of schistosomiasis control. This paper materially dissected the meaning of "China's culture for schistosomiasis control", i.e., people-first, government-oriented, science-respected, collective wisdom and efforts, and diversity-embracing. PMID:27089766

  19. China-Africa and China-Asia Collaboration on Schistosomiasis Control: A SWOT Analysis.

    PubMed

    Xu, J; Bergquist, R; Qian, Y-J; Wang, Q; Yu, Q; Peeling, R; Croft, S; Guo, J-G; Zhou, X-N

    2016-01-01

    Schistosomiasis, a disease caused by a trematode, parasitic worm, is a worldwide public health problem. In spite of great progress with regard to morbidity control, even elimination of this infection in recent decades, there are still challenges to overcome in sub-Saharan Africa and endemic areas in Southeast Asia. Regarded as one of the most successful countries with respect to schistosomiasis control, The People's Republic of China has accumulated considerable experience and learnt important lessons in various local settings that could benefit schistosomiasis control in other endemic countries. Based on an analysis of conceived strengths, weaknesses, opportunities and threats (SWOT) of potential collaborative activities with regard to schistosomiasis in Africa and Asia, this article addresses the importance of collaborative efforts and explores the priorities that would be expected to facilitate the transfer of Chinese experience to low- and middle-income countries in Africa and Asia. PMID:27137455

  20. From Incidentaloma to Suspicion of Malignancy: The Diverse Clinical Presentation of Gonadal Schistosomiasis mansoni

    PubMed Central

    Almeida, Laiana do Carmo; de Oliveira, Marbele Guimarães; Castro Pereira, Fábio Meira; de Bessa Júnior, José

    2013-01-01

    Schistosomiasis is the second most widespread parasitic disease in the world, second only to malaria. The usual places the Schistosoma mansoni can be found in are the rectal and sigmoidal venules, as well as other segments of the large intestine of men. It may also be present in other ectopic topographies. Gonadal schistosomiasis is an unusual presentation of Schistosomiasis mansoni and its different clinical signs and symptoms disrupt correct diagnosis and culminate in surgical treatment that is, in most cases, unnecessary. In this study, we report four cases of gonadal Schistosomiasis mansoni, two in the ovary and two in the testicles. These cases were clinically investigated as a bacterial infection, a benign neoplasm, and a suspected cancer, whilst one of them was an incidentaloma. PMID:24392230

  1. China-Africa and China-Asia Collaboration on Schistosomiasis Control: A SWOT Analysis.

    PubMed

    Xu, J; Bergquist, R; Qian, Y-J; Wang, Q; Yu, Q; Peeling, R; Croft, S; Guo, J-G; Zhou, X-N

    2016-01-01

    Schistosomiasis, a disease caused by a trematode, parasitic worm, is a worldwide public health problem. In spite of great progress with regard to morbidity control, even elimination of this infection in recent decades, there are still challenges to overcome in sub-Saharan Africa and endemic areas in Southeast Asia. Regarded as one of the most successful countries with respect to schistosomiasis control, The People's Republic of China has accumulated considerable experience and learnt important lessons in various local settings that could benefit schistosomiasis control in other endemic countries. Based on an analysis of conceived strengths, weaknesses, opportunities and threats (SWOT) of potential collaborative activities with regard to schistosomiasis in Africa and Asia, this article addresses the importance of collaborative efforts and explores the priorities that would be expected to facilitate the transfer of Chinese experience to low- and middle-income countries in Africa and Asia.

  2. Applications of Spatial Technology in Schistosomiasis Control Programme in The People's Republic of China.

    PubMed

    Wang, X-Y; He, J; Yang, K; Liang, S

    2016-01-01

    Schistosomiasis, as the important parasitic disease, has caused serious threats to human health globally. The People's Republic of China has acquired significant achievements based on large-scale interventions and innovational technology. The spatial technology was introduced in 1980s and widely used in the study and control of schistosomiasis in The People's Republic of China. This chapter reviews the progress and application of spatial technology in schistosomiasis control by analysing the spatiotemporal pattern of and the impact of ecological changes on schistosomiasis transmission, which have provided the information to design and select the control strategy, and assisted the establishment of the monitoring and early warning system in The People's Republic of China, especially in the marshland and mountainous regions.

  3. Intestinal Schistosomiasis as Unusual Aetiology for Acute Appendicitis, Nowadays a Rising Disease in Western Countries

    PubMed Central

    López de Cenarruzabeitia, I.; Landolfi, S.; Armengol Carrasco, M.

    2012-01-01

    Intestinal schistosomiasis as unusual aetiology for acute appendicitis, nowadays a rising disease in western countries. Recent changes in global migration has led to an immigration growth in our scenario, upsurging people coming from endemic areas of schistosomiasis. Schistosomal appendicitis, seldom reported in developed countries, is now an expected incrising entity in our hospitals during the near future. Due to this circumstances, we believe that schistosomiasis should be consider as a rising source for acute appendicitis in western countries. In order to illustrate this point, we present a case of a 45-years-old black man, from Africa, was admitted via A&E because of acute abdominal pain, located in right lower quadrant. Acute appendicitis was suspected, and he underwent laparotomy and appendectomy. Pathological study by microscope revealed a gangrenous appendix with abscesses and parasitic ova into the submucosal layer of the appendix, suggesting Schistosomiasis. PMID:22792502

  4. Proteomic changes at 8 weeks after infection are associated with chronic liver pathology in experimental schistosomiasis.

    PubMed

    Manivannan, Bhagyashree; Jordan, T William; Secor, W Evan; La Flamme, Anne Camille

    2012-03-16

    Chronic Schistosoma mansoni infection can present as a moderate or severe disease, termed intestinal or hepatosplenic schistosomiasis, respectively. Similarly, either moderate splenomegaly or hypersplenomegaly syndrome develops in CBA/J mice by 20weeks of infection and is similar to intestinal or hepatosplenic schistosomiasis respectively. Using this mouse model and two-dimensional differential in gel electrophoresis, the liver proteomic signatures of uninfected mice and mice infected for 6, 8, 12, or 20weeks were compared, and significant protein spots identified using mass spectrometry. We found the greatest number of changes at 12weeks suggesting that this period represents the peak time of change. Pathway analysis identified specific proteins and pathways that correlated to the pathological changes indicative of severe disease, and these pathways were involved as early as 8weeks after infection. These findings provide insight into the development of severe liver pathology in schistosomiasis and may aid in developing biomarkers for hepatosplenic schistosomiasis.

  5. Repurposing pharma assets: an accelerated mechanism for strengthening the schistosomiasis drug development pipeline.

    PubMed

    Ramamoorthi, Roopa; Graef, Katy M; Dent, Jennifer

    2015-01-01

    Schistosomiasis, one of 17 diseases deemed to be neglected by the World Health Organization, has received little attention from the biopharmaceutical industry. Due to this, only a handful of drugs have been developed to treat schistosomiasis, with only one, praziquantel, used in most endemic regions. Growing concern over resistance coupled with praziquantel's incomplete efficacy across all stages of the Schistosoma platyhelminth life cycle highlights the urgent need for new drugs. The WIPO Re:Search consortium is a platform whereupon biopharmaceutical company compounds are being repurposed to efficiently and cost-effectively develop new drugs for neglected diseases such as schistosomiasis. This article summarizes recent clinical-stage efforts to identify new antischistosomals and highlights biopharmaceutical company compounds with potential for repurposing to treat schistosomiasis.

  6. Web-based therapeutic exercise resource center as a treatment for knee osteoarthritis: a prospective cohort pilot study

    PubMed Central

    2014-01-01

    Background Although beneficial effects of exercise in the management of knee osteoarthritis (OA) have been established, only 14 -18% of patients with knee OA receive an exercise from their primary care provider. Patients with knee OA cite lack of physician exercise advice as a major reason why they do not exercise to improve their condition. The purpose of this pilot study was to investigate use of a web-based Therapeutic Exercise Resource Center (TERC) as a tool to prescribe strength, flexibility and aerobic exercise as part of knee OA treatment. It was hypothesized that significant change in clinical outcome scores would result from patients’ use of the TERC. Methods Sixty five individuals diagnosed with mild/moderate knee OA based on symptoms and radiographs were enrolled through outpatient physician clinics. Using exercise animations to facilitate proper technique, the TERC assigned and progressed patients through multiple levels of exercise intensity based on exercise history, co-morbidities and a validated measure of pain and function. Subjects completed a modified short form WOMAC (mSF-WOMAC), World Health Organization Quality of Life (WHO-QOL) and Knee Self-Efficacy Scale (K-SES) at baseline and completion of the 8 week program, and a user satisfaction survey. Outcomes were compared over time using paired t-tests and effect sizes calculated using partial point biserial (pr). Results Fifty two participants completed the 8 week program with average duration of knee pain 8.0 ± 11.0 yrs (25 females; 61.0 ± 9.4 yrs; body mass index, 28.8 ± 6.3 kg/m2). During the study period, all outcome measures improved: mSF-WOMAC scores decreased (better pain and function) (p < .001; large effect, pr = 0.70); WHO-QOL physical scores increased (p = .015; medium effect, pr = 0.33); and K-SES scores increased (p < .001; large effect, pr = 0.54). No significant differences were found in study outcomes as a function of gender, age, BMI

  7. Cervical cytology as a diagnostic tool for female genital schistosomiasis: Correlation to cervical atypia and Schistosoma polymerase chain reaction

    PubMed Central

    Pillay, Pavitra; van Lieshout, Lisette; Taylor, Myra; Sebitloane, Motshedisi; Zulu, Siphosenkosi Gift; Kleppa, Elisabeth; Roald, Borghild; Kjetland, Eyrun Floerecke

    2016-01-01

    Background: Female genital schistosomiasis (FGS) is a tissue reaction to lodged ova of Schistosoma haematobium in the genital mucosa. Lesions can make the mucosa friable and prone to bleeding and discharge. Women with FGS may have an increased risk of HIV acquisition, and FGS may act as a cofactor in the development of cervical cancer. Objectives: To explore cytology as a method for diagnosing FGS and to discuss the diagnostic challenges in low-resource rural areas. The correlation between FGS and squamous cell atypia (SCA) is also explored and discussed. Cytology results are compared to Schistosoma polymerase chain reaction (PCR) in vaginal lavage and urine and in urine microscopy. Materials and Methods: In a clinical study, 394 women aged between 16 and 23 years from rural high schools in KwaZulu-Natal, South Africa, underwent structured interviews and the following laboratory tests: Cytology Papanicolaou (Pap) smears for S. haematobium ova and cervical SCA, real-time PCR for Schistosoma-specific DNA in vaginal lavage and urine samples, and urine microscopy for the presence of S. haematobium ova. Results: In Pap smears, S. haematobium ova were detected in 8/394 (2.0%). SCA was found in 107/394 (27.1%), seven of these had high-grade squamous intraepithelial lesion (HSIL). Schistosoma specific DNA was detected in 38/394 (9.6%) of vaginal lavages and in 91/394 (23.0%) of urines. Ova were found microscopically in 78/394 (19.7%) of urines. Conclusion: Schistosoma PCR on lavage was a better way to diagnose FGS compared to cytology. There was a significant association between S. haematobium ova in Pap smears and the other diagnostic methods. In low-resource Schistosoma-endemic areas, it is important that cytology screeners are aware of diagnostic challenges in the identification of schistosomiasis in addition to the cytological diagnosis of SCA. Importantly, in this study, three of eight urines were negative but showed Schistosoma ova in their Pap smear, and one of them

  8. [Diagnosis and treatment of bladder schistosomiasis from penitentiary primary care: case report].

    PubMed

    Bedoya del Campillo, A; Martínez-Carpio, P A; Leal, M J; Lleopart, N

    2012-01-01

    We describe a case of a patient from Senegal with voiding symptoms and microscopic hematuria diagnosed and treated for bladder schistosomiasis in the medical services of the Youth Prison in Barcelona. According to our information in the Medline database no bladder schistosomiasis cases have been seen in primary care outside endemic areas. Patients can be diagnosed and treated before referral to specialized care for further study of possible complications. PMID:22801651

  9. Canine schistosomiasis In North America: an underdiagnosed disease with an expanding distribution.

    PubMed

    Johnson, Eileen M

    2010-03-01

    Heterobilharzia americana, a digenean trematode in the family Schistosomatidae, is the etiologic agent of canine schistosomiasis in the southeastern United States. A few cases of canine schistosomiasis have been reported in Florida, Louisiana, North Carolina, Texas, and, recently, Kansas. The natural definitive host for the fluke is the raccoon; however, infections have been detected in nutrias, bobcats, mountain lions, opossums, white-tailed deer, swamp rabbits, armadillos, coyotes, red wolves, red wolf-coyote crosses, Brazilian tapirs, minks, and beavers. PMID:20473851

  10. Extent of morbidity associated with schistosomiasis infection in Malawi: a review paper.

    PubMed

    Mtethiwa, Austin H N; Nkwengulila, Gamba; Bakuza, Jared; Sikawa, Daniel; Kazembe, Abigail

    2015-01-01

    Data on the extent of the burden due to schistosomiasis is sparse in most Sub-Saharan African countries. However, this data is crucial for triggering medical attention. A review of extent of morbidity and determinants associated with schistosomiasis in Malawi was therefore conducted to quantify the infection in order to concretise the need for medical intervention. A systematic and traditional search strategy was used to find literature for the review, whilst exclusion and inclusion criteria were used to identify appropriate articles. Logistic regression curves of epidemiological model Y = (a + bx (c) )/(1 + bx (c) ) and the recommendation that schistosomiasis prevalence can be used to estimate morbidity were employed to quantify morbidity at various infection stages. Morbidity was quantified as a direct proportion of the population and the respective national schistosomiasis prevalence. Findings showed that both S. mansoni and S. haematobium are present in Malawi with the latter highly prevalent (50%). Furthermore, out of the estimated population of 16,829 million, approximately 8.4 million have schistosomiasis, with about 4.4 million of these aged 18 years and below. The most frequent manifestation is Katayama syndrome, while ascites is the lowest, impacting about 3.0 million and 960 individuals, respectively. Localised studies on association of schistosomiasis infection to risk factors such as occupation, age and gender found odds ratio (OR) ranging from 1.29 to 5.37. Morbidity due to schistosomiasis is high in Malawi. It is therefore recommended that a more detailed study on the determinants of high schistosomiasis and re-evaluation of the current control measures be conducted if the current morbidity statistics are to be remarkably reduced.

  11. [Impact of the three gorges dam construction on transmission of schistosomiasis in the reservoir area].

    PubMed

    Zhang, Hui-juan; Guo, Jia-gang

    2006-06-01

    Possible impact of ecological and social environmental changes due to the construction of the Three Gorges Dam on the transmission of schistosomiasis draws great attention of the health authority and publics. This article reviews the situation and progress of research on schistosomiasis transmission in reservoir area from three aspects: the possibility of snail spreading and breeding, imported infection sources and social behavioral factors of the people.

  12. Monitoring schistosomiasis risk in East China over space and time using a Bayesian hierarchical modeling approach

    PubMed Central

    Hu, Yi; Ward, Michael P.; Xia, Congcong; Li, Rui; Sun, Liqian; Lynn, Henry; Gao, Fenghua; Wang, Qizhi; Zhang, Shiqing; Xiong, Chenglong; Zhang, Zhijie; Jiang, Qingwu

    2016-01-01

    Schistosomiasis remains a major public health problem and causes substantial economic impact in east China, particularly along the Yangtze River Basin. Disease forecasting and surveillance can assist in the development and implementation of more effective intervention measures to control disease. In this study, we applied a Bayesian hierarchical spatio-temporal model to describe trends in schistosomiasis risk in Anhui Province, China, using annual parasitological and environmental data for the period 1997–2010. A computationally efficient approach–Integrated Nested Laplace Approximation–was used for model inference. A zero-inflated, negative binomial model best described the spatio-temporal dynamics of schistosomiasis risk. It predicted that the disease risk would generally be low and stable except for some specific, local areas during the period 2011–2014. High-risk counties were identified in the forecasting maps: three in which the risk remained high, and two in which risk would become high. The results indicated that schistosomiasis risk has been reduced to consistently low levels throughout much of this region of China; however, some counties were identified in which progress in schistosomiasis control was less than satisfactory. Whilst maintaining overall control, specific interventions in the future should focus on these refractive counties as part of a strategy to eliminate schistosomiasis from this region. PMID:27053447

  13. Monitoring schistosomiasis risk in East China over space and time using a Bayesian hierarchical modeling approach.

    PubMed

    Hu, Yi; Ward, Michael P; Xia, Congcong; Li, Rui; Sun, Liqian; Lynn, Henry; Gao, Fenghua; Wang, Qizhi; Zhang, Shiqing; Xiong, Chenglong; Zhang, Zhijie; Jiang, Qingwu

    2016-01-01

    Schistosomiasis remains a major public health problem and causes substantial economic impact in east China, particularly along the Yangtze River Basin. Disease forecasting and surveillance can assist in the development and implementation of more effective intervention measures to control disease. In this study, we applied a Bayesian hierarchical spatio-temporal model to describe trends in schistosomiasis risk in Anhui Province, China, using annual parasitological and environmental data for the period 1997-2010. A computationally efficient approach-Integrated Nested Laplace Approximation-was used for model inference. A zero-inflated, negative binomial model best described the spatio-temporal dynamics of schistosomiasis risk. It predicted that the disease risk would generally be low and stable except for some specific, local areas during the period 2011-2014. High-risk counties were identified in the forecasting maps: three in which the risk remained high, and two in which risk would become high. The results indicated that schistosomiasis risk has been reduced to consistently low levels throughout much of this region of China; however, some counties were identified in which progress in schistosomiasis control was less than satisfactory. Whilst maintaining overall control, specific interventions in the future should focus on these refractive counties as part of a strategy to eliminate schistosomiasis from this region.

  14. Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Schistosomiasis and pulmonary arterial hypertension.

    PubMed

    Butrous, Ghazwan

    2014-07-01

    Schistosomiasis is caused by infection with the parasite Schistosoma, which is a flat-worm or fluke. The dominant species are Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium. Schistosomiasis is the third most common parasitic disease in the world after malaria and amoebiasis. It is endemic in more than 70 countries affecting about 200 million people worldwide, of whom 80% are in sub-Saharan Africa. There are pockets of infection in north-eastern Brazil, near the Yangtze River in China, and some pockets in south East Asia. In the East Mediterranean regions, the Schistosoma have been reported in Iraq and Egypt as well as in Sudan. The latter has the highest infection rate nowadays, particularly in the Al Jazeera area, due to the poor Schistosoma control program. In the Arabian peninsula, schistosomiasis has been reported in southwest part of Saudi Arabia, mainly in the Asir province and Jizan province, which lay in the southwest corner of Saudi Arabia and directly north of the border with Yemen. The efforts to control schistosomiasis have been very successful in Saudi Arabia due to the irrigation system control. However, the infection is prone in Yemen, where the schistosomiasis control is much less strict. Thus as a result, the problem still exists due to transmigration of the populations from both countries. As a cause of pulmonary arterial hypertension (PAH), schistosomiasis is still under diagnosed and undertreated. This article with give a highlight about the pathophysiology of the disease and both diagnostic and therapeutic strategies. PMID:25076995

  15. Monitoring schistosomiasis risk in East China over space and time using a Bayesian hierarchical modeling approach.

    PubMed

    Hu, Yi; Ward, Michael P; Xia, Congcong; Li, Rui; Sun, Liqian; Lynn, Henry; Gao, Fenghua; Wang, Qizhi; Zhang, Shiqing; Xiong, Chenglong; Zhang, Zhijie; Jiang, Qingwu

    2016-01-01

    Schistosomiasis remains a major public health problem and causes substantial economic impact in east China, particularly along the Yangtze River Basin. Disease forecasting and surveillance can assist in the development and implementation of more effective intervention measures to control disease. In this study, we applied a Bayesian hierarchical spatio-temporal model to describe trends in schistosomiasis risk in Anhui Province, China, using annual parasitological and environmental data for the period 1997-2010. A computationally efficient approach-Integrated Nested Laplace Approximation-was used for model inference. A zero-inflated, negative binomial model best described the spatio-temporal dynamics of schistosomiasis risk. It predicted that the disease risk would generally be low and stable except for some specific, local areas during the period 2011-2014. High-risk counties were identified in the forecasting maps: three in which the risk remained high, and two in which risk would become high. The results indicated that schistosomiasis risk has been reduced to consistently low levels throughout much of this region of China; however, some counties were identified in which progress in schistosomiasis control was less than satisfactory. Whilst maintaining overall control, specific interventions in the future should focus on these refractive counties as part of a strategy to eliminate schistosomiasis from this region. PMID:27053447

  16. Alzheimer - resources

    MedlinePlus

    Resources - Alzheimer ... The following organizations are good resources for information on Alzheimer disease : Alzheimer's Association -- www.alz.org Alzheimer's Disease Education and Referral Center -- www.nia.nih.gov/alzheimers ...

  17. SIDS - resources

    MedlinePlus

    Resources - SIDS ... The following organizations are good resources for information on SIDS : American SIDS Institute -- www.sids.org Centers for Disease Control and Prevention -- www.cdc.gov/sids National ...

  18. Infertility - resources

    MedlinePlus

    Resources - infertility ... The following organizations are good resources for information on infertility : Centers for Disease Control and Prevention -- www.cdc/gov/reproductivehealth/infertility March of Dimes -- www.marchofdimes.com/ ...

  19. Assessing the influence of water level on schistosomiasis in Dongting Lake region before and after the construction of Three Gorges Dam.

    PubMed

    Li, Zhongwu; Nie, Xiaodong; Zhang, Yan; Huang, Jinquan; Huang, Bin; Zeng, Guangming

    2016-01-01

    Schistosomiasis is a severe public health problem in the Dongting Lake region, and its distribution, prevalence, and intensity of infection are particularly sensitive to environmental changes. In this study, the human and bovine schistosomiasis variations in the Dongting Lake region were studied from 1996 to 2010, and the relationships between schistosomiasis and water level were examined. Furthermore, based on these results, the potential effects of the Three Gorges Dam (TGD) on schistosomiasis were investigated. Results showed an increase in human schistosomiasis and in the scope of seriously affected regions, along with a decrease in bovine schistosomiasis. Human schistosomiasis was negatively correlated with water level during wet season (from May to October), particularly the average water level in October. This finding indicated that the decreasing water level may be highly related to the increasing of human schistosomiasis in the Dongting Lake region. Based on this result and the variation of schistosomiasis before and after the construction and operation of TGD, the impoundment of the Three Gorges reservoir is believed to decrease the water level and increase the contact between people and schistosomiasis. Therefore, the TGD, which is operated by regulating water and scheduling water operations, is not good for the control of human schistosomiasis in the Dongting Lake region. Although the extent of the influence of the TGD on schistosomiasis remains unclear, the influence of the TGD on preventing and controlling schistosomiasis should not be ignored.

  20. Assessing the influence of water level on schistosomiasis in Dongting Lake region before and after the construction of Three Gorges Dam.

    PubMed

    Li, Zhongwu; Nie, Xiaodong; Zhang, Yan; Huang, Jinquan; Huang, Bin; Zeng, Guangming

    2016-01-01

    Schistosomiasis is a severe public health problem in the Dongting Lake region, and its distribution, prevalence, and intensity of infection are particularly sensitive to environmental changes. In this study, the human and bovine schistosomiasis variations in the Dongting Lake region were studied from 1996 to 2010, and the relationships between schistosomiasis and water level were examined. Furthermore, based on these results, the potential effects of the Three Gorges Dam (TGD) on schistosomiasis were investigated. Results showed an increase in human schistosomiasis and in the scope of seriously affected regions, along with a decrease in bovine schistosomiasis. Human schistosomiasis was negatively correlated with water level during wet season (from May to October), particularly the average water level in October. This finding indicated that the decreasing water level may be highly related to the increasing of human schistosomiasis in the Dongting Lake region. Based on this result and the variation of schistosomiasis before and after the construction and operation of TGD, the impoundment of the Three Gorges reservoir is believed to decrease the water level and increase the contact between people and schistosomiasis. Therefore, the TGD, which is operated by regulating water and scheduling water operations, is not good for the control of human schistosomiasis in the Dongting Lake region. Although the extent of the influence of the TGD on schistosomiasis remains unclear, the influence of the TGD on preventing and controlling schistosomiasis should not be ignored. PMID:26661964