ISS National Laboratory Education Project: Enhancing and Innovating the ISS as an Educational Venue

NASA Technical Reports Server (NTRS)

Melvin, Leland D.

2011-01-01

The vision is to develop the ISS National Laboratory Education Project (ISS NLE) as a national resource for Science, Technology, Engineering and Mathematics (STEM) education, utilizing the unique educational venue of the International Space Station per the NASA Congressional Authorization Act of 2005. The ISS NLE will serve as an educational resource which enables educational activities onboard the ISS and in the classroom. The ISS NLE will be accessible to educators and students from kindergarten to post-doctoral studies, at primary and secondary schools, colleges and universities. Additionally, the ISS NLE will provide ISS-related STEM education opportunities and resources for learners of all ages via informal educational institutions and venues Though U.S. Congressional direction emphasized the involvement of U.S. students, many ISS-based educational activities have international student and educator participation Over 31 million students around the world have participated in several ISS-related education activities.

Evaluation of Revised International Staging System (R-ISS) for transplant-eligible multiple myeloma patients.

PubMed

González-Calle, Verónica; Slack, Abigail; Keane, Niamh; Luft, Susan; Pearce, Kathryn E; Ketterling, Rhett P; Jain, Tania; Chirackal, Sintosebastian; Reeder, Craig; Mikhael, Joseph; Noel, Pierre; Mayo, Angela; Adams, Roberta H; Ahmann, Gregory; Braggio, Esteban; Stewart, A Keith; Bergsagel, P Leif; Van Wier, Scott A; Fonseca, Rafael

2018-04-06

The International Myeloma Working Group has proposed the Revised International Staging System (R-ISS) for risk stratification of multiple myeloma (MM) patients. There are a limited number of studies that have validated this risk model in the autologous stem cell transplant (ASCT) setting. In this retrospective study, we evaluated the applicability and value for predicting survival of the R-ISS model in 134 MM patients treated with new agents and ASCT at the Mayo Clinic in Arizona and the University Hospital of Salamanca in Spain. The patients were reclassified at diagnosis according to the R-ISS: 44 patients (33%) had stage I, 75 (56%) had stage II, and 15 (11%) had stage III. After a median follow-up of 60 months, R-ISS assessed at diagnosis was an independent predictor for overall survival (OS) after ASCT, with median OS not reached, 111 and 37 months for R-ISS I, II and III, respectively (P < 0.001). We also found that patients belonging to R-ISS II and having high-risk chromosomal abnormalities (CA) had a significant shorter median OS than those with R-ISS II without CA: 70 vs. 111 months, respectively. Therefore, this study lends further support for the R-ISS as a reliable prognostic tool for estimating survival in transplant myeloma patients and suggests the importance of high-risk CA in the R-ISS II group.

ISS Local Environment Spectrometers (ISLES)

NASA Technical Reports Server (NTRS)

Krause, Linda Habash; Gilchrist, Brian E.

2014-01-01

In order to study the complex interactions between the space environment surrounding the ISS and the ISS surface materials, we propose to use lowcost, high-TRL plasma sensors on the ISS robotic arm to probe the ISS space environment. During many years of ISS operation, we have been able to condut effective (but not perfect) extravehicular activities (both human and robotic) within the perturbed local ISS space environment. Because of the complexity of the interaction between the ISS and the LEO space environment, there remain important questions, such as differential charging at solar panel junctions (the so-called "triple point" between conductor, dielectric, and space plasma), increased chemical contamination due to ISS surface charging and/or thruster activation, water dumps, etc, and "bootstrap" charging of insulating surfaces. Some compelling questions could synergistically draw upon a common sensor suite, which also leverages previous and current MSFC investments. Specific questions address ISS surface charging, plasma contactor plume expansion in a magnetized drifting plasma, and possible localized contamination effects across the ISS.

Interplanetary Transit Simulations Using the International Space Station

NASA Technical Reports Server (NTRS)

Charles, J. B.; Arya, Maneesh

2010-01-01

It has been suggested that the International Space Station (ISS) be utilized to simulate the transit portion of long-duration missions to Mars and near-Earth asteroids (NEA). The ISS offers a unique environment for such simulations, providing researchers with a high-fidelity platform to study, enhance, and validate technologies and countermeasures for these long-duration missions. From a space life sciences perspective, two major categories of human research activities have been identified that will harness the various capabilities of the ISS during the proposed simulations. The first category includes studies that require the use of the ISS, typically because of the need for prolonged weightlessness. The ISS is currently the only available platform capable of providing researchers with access to a weightless environment over an extended duration. In addition, the ISS offers high fidelity for other fundamental space environmental factors, such as isolation, distance, and accessibility. The second category includes studies that do not require use of the ISS in the strictest sense, but can exploit its use to maximize their scientific return more efficiently and productively than in ground-based simulations. In addition to conducting Mars and NEA simulations on the ISS, increasing the current increment duration on the ISS from 6 months to a longer duration will provide opportunities for enhanced and focused research relevant to long-duration Mars and NEA missions. Although it is currently believed that increasing the ISS crew increment duration to 9 or even 12 months will pose little additional risk to crewmembers, additional medical monitoring capabilities may be required beyond those currently used for the ISS operations. The use of the ISS to simulate aspects of Mars and NEA missions seems practical, and it is recommended that planning begin soon, in close consultation with all international partners.

Corporate sponsored education initiatives on board the ISS

NASA Astrophysics Data System (ADS)

Durham, Ian T.; Durham, Alyson S.; Pawelczyk, James A.; Brod, Lawrence B.; Durham, Thomas F.

1999-01-01

This paper proposes the creation of a corporate sponsored ``Lecture from Space'' program on board the International Space Station (ISS) with funding coming from a host of new technology and marketing spin-offs. This program would meld existing education initiatives in NASA with new corporate marketing techniques. Astronauts in residence on board the ISS would conduct short ten to fifteen minute live presentations and/or conduct interactive discussions carried out by a teacher in the classroom. This concept is similar to a program already carried out during the Neurolab mission on Shuttle flight STS-90. Building on that concept, the interactive simulcasts would be broadcast over the Internet and linked directly to computers and televisions in classrooms worldwide. In addition to the live broadcasts, educational programs and demonstrations can be recorded in space, and marketed and sold for inclusion in television programs, computer software, and other forms of media. Programs can be distributed directly into classrooms as an additional presentation supplement, as well as over the Internet or through cable and broadcast television, similar to the Canadian Discovery Channel's broadcasts of the Neurolab mission. Successful marketing and advertisement can eventually lead to the creation of an entirely new, privately run cottage industry involving the distribution and sale of educationally related material associated with the ISS that would have the potential to become truly global in scope. By targeting areas of expertise and research interest in microgravity, a large curriculum could be developed using space exploration as a unifying theme. Expansion of this concept could enhance objectives already initiated through the International Space University to include elementary and secondary school students. The ultimate goal would be to stimulate interest in space and space related sciences in today's youth through creative educational marketing initiatives while at the same time drawing funds almost entirely from the private sector.

[Retrospective computation of the ISS in multiple trauma patients: Potential pitfalls and limitations of findings in full body CT scans].

PubMed

Bogner, V; Brumann, M; Kusmenkov, T; Kanz, K G; Wierer, M; Berger, F; Mutschler, W

2016-03-01

The Injury Severity Score (ISS) is a well-established anatomical scoring system for polytraumatized patients. However, any inaccuracy in the Abbreviated Injury Score (AIS) directly increases the ISS impreciseness. Using the full body computed tomography (CT) scan report, ISS computation can be associated with certain pitfalls. This study evaluates interpretation variations depending on radiological reports and indicates requirements to reliably determine the ISS. The ISS of 81 polytraumatized patients was calculated based on the full body CT scan report. If an injury could not be attributed to a precise AIS cipher, the minimal and maximal ISS was computed. Real ISS included all conducted investigations, intraoperative findings, and final medical reports. The differences in ISS min, ISS max, and ISS real were evaluated using the Kruskal-Wallis test (p<0.05) and plotted in a linear regression analysis. Mean ISS min was 24.0 (± 0.7 SEM) points, mean ISS real 38.6 (±1.3 SEM) and mean ISS max was 48.3 (±1.4 SEM) points. All means were significantly different compared to one another (p<0.001). The difference between possible and real ISS showed a distinctive variation. Mean deviation was 9.7 (±0.9 SEM) points downward and 14.5 (±1.1 SEM) points upward. The difference between deviation to ISS min and ISS max was highly significant (p<0.001). Objectification of injury severity in polytraumatized patients using the ISS is an internationally well-established method in clinical and scientific settings. The full body CT scan report must meet distinct criteria and has to be written in acquaintance to the AIS scale if intended to be used for correct ISS computation.

The Military Injury Severity Score (mISS): A better predictor of combat mortality than Injury Severity Score (ISS).

PubMed

Le, Tuan D; Orman, Jean A; Stockinger, Zsolt T; Spott, Mary Ann; West, Susan A; Mann-Salinas, Elizabeth A; Chung, Kevin K; Gross, Kirby R

2016-07-01

The Military Injury Severity Score (mISS) was developed to better predict mortality in complex combat injuries but has yet to be validated. US combat trauma data from Afghanistan and Iraq from January 1, 2003, to December 31, 2014, from the US Department of Defense Trauma Registry (DoDTR) were analyzed. Military ISS, a variation of the ISS, was calculated and compared with standard ISS scores.Receiver operating characteristic curve, area under the curve, and Hosmer-Lemeshow statistics were used to discriminate and calibrate between mISS and ISS. Wilcoxon-Mann-Whitney, t test and χ tests were used, and sensitivity and specificity calculated. Logistic regression was used to calculate the likelihood of mortality associated with levels of mISS and ISS overall. Thirty thousand three hundred sixty-four patients were analyzed. Most were male (96.8%). Median age was 24 years (interquartile range [IQR], 21-29 years). Battle injuries comprised 65.3%. Penetrating (39.5%) and blunt (54.2%) injury types and explosion (51%) and gunshot wound (15%) mechanisms predominated. Overall mortality was 6.0%.Median mISS and ISS were similar in survivors (5 [IQR, 2-10] vs. 5 [IQR, 2-10]) but different in nonsurvivors, 30 (IQR, 16-75) versus 24 (IQR, 9-23), respectively (p < 0.0001). Military ISS and ISS were discordant in 17.6% (n = 5,352), accounting for 56.2% (n = 1,016) of deaths. Among cases with discordant severity scores, the median difference between mISS and ISS was 9 (IQR, 7-16); range, 1 to 59. Military ISS and ISS shared 78% variability (R = 0.78).Area under the curve was higher in mISS than in ISS overall (0.82 vs. 0.79), for battle injury (0.79 vs. 0.76), non-battle injury (0.87 vs. 0.86), penetrating (0.81 vs. 0.77), blunt (0.77 vs. 0.75), explosion (0.81 vs. 0.78), and gunshot (0.79 vs. 0.73), all p < 0.0001. Higher mISS and ISS were associated with higher mortality. Compared with ISS, mISS had higher sensitivity (81.2 vs. 63.9) and slightly lower specificity (80.2 vs. 85.7). Military ISS predicts combat mortality better than does ISS. Prognostic and epidemiologic study, level III.

Validating the Use of ICD-9 Code Mapping to Generate Injury Severity Scores

PubMed Central

Fleischman, Ross J.; Mann, N. Clay; Dai, Mengtao; Holmes, James F.; Wang, N. Ewen; Haukoos, Jason; Hsia, Renee Y.; Rea, Thomas; Newgard, Craig D.

2017-01-01

The Injury Severity Score (ISS) is a measure of injury severity widely used for research and quality assurance in trauma. Calculation of ISS requires chart abstraction, so it is often unavailable for patients cared for in nontrauma centers. Whether ISS can be accurately calculated from International Classification of Diseases, Ninth Revision (ICD-9) codes remains unclear. Our objective was to compare ISS derived from ICD-9 codes with those coded by trauma registrars. This was a retrospective study of patients entered into 9 U.S. trauma registries from January 2006 through December 2008. Two computer programs, ICDPIC and ICDMAP, were used to derive ISS from the ICD-9 codes in the registries. We compared derived ISS with ISS hand-coded by trained coders. There were 24,804 cases with a mortality rate of 3.9%. The median ISS derived by both ICDPIC (ISS-ICDPIC) and ICDMAP (ISS-ICDMAP) was 8 (interquartile range [IQR] = 4–13). The median ISS in the registry (ISS-registry) was 9 (IQR = 4–14). The median difference between either of the derived scores and ISS-registry was zero. However, the mean ISS derived by ICD-9 code mapping was lower than the hand-coded ISS in the registries (1.7 lower for ICDPIC, 95% CI [1.7, 1.8], Bland–Altman limits of agreement = −10.5 to 13.9; 1.8 lower for ICDMAP, 95% CI [1.7, 1.9], limits of agreement = −9.6 to 13.3). ICD-9-derived ISS slightly underestimated ISS compared with hand-coded scores. The 2 methods showed moderate to substantial agreement. Although hand-coded scores should be used when possible, ICD-9-derived scores may be useful in quality assurance and research when hand-coded scores are unavailable. PMID:28033134

International Space Station (ISS)

NASA Image and Video Library

2003-05-01

Aboard the International Space Station (ISS), the Russian Lada greenhouse provides home to an experiment that investigates plant development and genetics. Space grown peas have dried and "gone to seed." The crew of the ISS will soon harvest the seeds. Eventually some will be replanted onboard the ISS, and some will be returned to Earth for further study.

Exit Presentation Fall 2013

NASA Technical Reports Server (NTRS)

Yang, Qi Rong

2014-01-01

Our current International Space Station Probabilistic Risk Assessment (ISS PRA) model assumes all collisions between a visiting vehicle (VV) and the ISS result in worst case loss of the ISS crew and the vehicle (LOCV). Drawing results from the Mir-Progress collision, we know this assumption is inaccurate because that collision did not lead to LOCV. Therefore the PRA team is conducting a study to determine the likelihood of LOCV when a collision occurs between a VV and the ISS. Kinetic energy is calculated and converted to pounds of TNT for the moving VVs when they collide with the ISS. Different scenarios are evaluated to obtain collision related data such as translational kinetic energy and rotational kinetic energy. These calculated data are integrated into the results from the expert elicitation performed on the Mir- Progress collision. As a result of this study, the PRA model will now calculate the probability of a VV collision with ISS, the probability that collision will result in Loss of Soyuz Crew (LOC) or Loss of ISS Crew and Vehicle (LOCV).

Applications of the International Space Station Probabilistic Risk Assessment Model

NASA Technical Reports Server (NTRS)

Grant, Warren; Lutomski, Michael G.

2011-01-01

Recently the International Space Station (ISS) has incorporated more Probabilistic Risk Assessments (PRAs) in the decision making process for significant issues. Future PRAs will have major impact to ISS and future spacecraft development and operations. These PRAs will have their foundation in the current complete ISS PRA model and the current PRA trade studies that are being analyzed as requested by ISS Program stakeholders. ISS PRAs have recently helped in the decision making process for determining reliability requirements for future NASA spacecraft and commercial spacecraft, making crew rescue decisions, as well as making operational requirements for ISS orbital orientation, planning Extravehicular activities (EVAs) and robotic operations. This paper will describe some applications of the ISS PRA model and how they impacted the final decision. This paper will discuss future analysis topics such as life extension, requirements of new commercial vehicles visiting ISS.

Development and psychometric properties of the Inner Strength Scale.

PubMed

Lundman, Berit; Viglund, Kerstin; Aléx, Lena; Jonsén, Elisabeth; Norberg, Astrid; Fischer, Regina Santamäki; Strandberg, Gunilla; Nygren, Björn

2011-10-01

Four dimensions of inner strength were previously identified in a meta-theoretical analysis: firmness, creativity, connectedness, and flexibility. The aim of this study was to develop an Inner Strength Scale (ISS) based on those four dimensions and to evaluate its psychometric properties. An initial version of ISS was distributed for validation purpose with the Rosenberg Self-Esteem Scale, the resilience scale, and the sense of Coherence Scale. A convenience sample of 391 adults, aged 19-90 years participated. Principal component analysis (PCA) and confirmatory factor analysis (CFA) were used in the process of exploring, evaluating, and reducing the 63-item ISS to the 20-item ISS. Cronbach's alpha and test-retest were used to measure reliability. CFA showed satisfactory goodness-of-fit for the 20-item ISS. The analysis supported a fourfactor solution explaining 51% of the variance. Cronbach's alpha on the 20-item ISS was 0.86, and the test-retest showed stability over time (r=0.79). The ISS was found to be a valid and reliable instrument for capturing a multifaceted understanding of inner strength. Further tests of psychometric properties of the ISS will be performed in forthcoming studies. Copyright © 2011 Elsevier Ltd. All rights reserved.

Prevalence and Correlates of Insufficient Sleep Syndrome in Japanese Young Adults: A Web-Based Cross-Sectional Study.

PubMed

Morita, Yuko; Sasai-Sakuma, Taeko; Asaoka, Shoichi; Inoue, Yuichi

2015-10-15

This study investigated the prevalence and risk factors of insufficient sleep syndrome (ISS), and factors associated with daytime dysfunction in the disorder in Japanese young adults. In this cross-sectional study, a web-based questionnaire survey was used to assess demographic variables, sleep habits and quality, depressive symptoms, and health-related quality of life (HRQOL) in 2,276 participants aged 20-25. Eleven percent of participants were classified as having ISS. Multiple logistic regression analysis revealed that the presence of ISS was significantly associated with social status (student or full-time employee). The participants with ISS had significantly higher depression scores and lower mental component summary scores than healthy sleepers. In the participants with ISS, a delayed sleep-wake schedule was extracted as a factor associated with worse mental component summary. Results indicate a relatively high proportion of Japanese young adults suffer from ISS, and that the condition is associated with a social status of student or full-time employee. Moreover, a delayed sleep-wake schedule may lead to further deterioration of mental HRQOL in ISS-affected persons. © 2015 American Academy of Sleep Medicine.

Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project.

PubMed

Avet-Loiseau, H; Durie, B G M; Cavo, M; Attal, M; Gutierrez, N; Haessler, J; Goldschmidt, H; Hajek, R; Lee, J H; Sezer, O; Barlogie, B; Crowley, J; Fonseca, R; Testoni, N; Ross, F; Rajkumar, S V; Sonneveld, P; Lahuerta, J; Moreau, P; Morgan, G

2013-03-01

The combination of serum β2-microglobulin and albumin levels has been shown to be highly prognostic in myeloma as the International Staging System (ISS). The aim of this study was to assess the independent contributions of ISS stage and cytogenetic abnormalities in predicting outcomes. A retrospective analysis of international studies looking at both ISS and cytogenetic abnormalities was performed in order to assess the potential role of combining ISS stage and cytogenetics to predict survival. This international effort used the International Myeloma Working Group database of 12 137 patients treated worldwide for myeloma at diagnosis, of whom 2309 had cytogenetic studies and 5387 had analyses by fluorescent in situ hybridization (iFISH). Comprehensive analyses used 2642 patients with sufficient iFISH data available. Using the comprehensive iFISH data, combining both t(4;14) and deletion (17p), along with ISS stage, significantly improved the prognostic assessment in terms of progression-free survival and overall survival. The additional impact of patient age and use of high-dose therapy was also demonstrated. In conclusion, the combination of iFISH data with ISS staging significantly improves risk assessment in myeloma.

The value of the injury severity score in pediatric trauma: Time for a new definition of severe injury?

PubMed

Brown, Joshua B; Gestring, Mark L; Leeper, Christine M; Sperry, Jason L; Peitzman, Andrew B; Billiar, Timothy R; Gaines, Barbara A

2017-06-01

The Injury Severity Score (ISS) is the most commonly used injury scoring system in trauma research and benchmarking. An ISS greater than 15 conventionally defines severe injury; however, no studies evaluate whether ISS performs similarly between adults and children. Our objective was to evaluate ISS and Abbreviated Injury Scale (AIS) to predict mortality and define optimal thresholds of severe injury in pediatric trauma. Patients from the Pennsylvania trauma registry 2000-2013 were included. Children were defined as younger than 16 years. Logistic regression predicted mortality from ISS for children and adults. The optimal ISS cutoff for mortality that maximized diagnostic characteristics was determined in children. Regression also evaluated the association between mortality and maximum AIS in each body region, controlling for age, mechanism, and nonaccidental trauma. Analysis was performed in single and multisystem injuries. Sensitivity analyses with alternative outcomes were performed. Included were 352,127 adults and 50,579 children. Children had similar predicted mortality at ISS of 25 as adults at ISS of 15 (5%). The optimal ISS cutoff in children was ISS greater than 25 and had a positive predictive value of 19% and negative predictive value of 99% compared to a positive predictive value of 7% and negative predictive value of 99% for ISS greater than 15 to predict mortality. In single-system-injured children, mortality was associated with head (odds ratio, 4.80; 95% confidence interval, 2.61-8.84; p < 0.01) and chest AIS (odds ratio, 3.55; 95% confidence interval, 1.81-6.97; p < 0.01), but not abdomen, face, neck, spine, or extremity AIS (p > 0.05). For multisystem injury, all body region AIS scores were associated with mortality except extremities. Sensitivity analysis demonstrated ISS greater than 23 to predict need for full trauma activation, and ISS greater than 26 to predict impaired functional independence were optimal thresholds. An ISS greater than 25 may be a more appropriate definition of severe injury in children. Pattern of injury is important, as only head and chest injury drive mortality in single-system-injured children. These findings should be considered in benchmarking and performance improvement efforts. Epidemiologic study, level III.

ISS groups: are we speaking the same language?

PubMed

Rozenfeld, Michael; Radomislensky, Irina; Freedman, Laurence; Givon, Adi; Novikov, Iliya; Peleg, Kobi

2014-10-01

Despite ISS being a widely accepted tool for measuring injury severity, many researchers and practitioners use different partition of ISS into severity groups. The lack of uniformity in ISS use inhibits proper comparisons between different studies. Creation of ISS group boundaries based on single AIS value squares and their sums was proposed in 1988 during Major Trauma Study (MTOS) in the USA, but was not validated by analysis of large databases. A validation study analysing 316,944 patients in the Israeli National Trauma registry (INTR) and 249,150 patients in the American National Trauma Data Bases (NTDB). A binary algorithm (Classification and Regression Trees (CART)) was used to detect the most significantly different ISS groups and was also applied to original MTOS data. The division of ISS into groups by the CART algorithm was identical in both Trauma Registries and very similar to original division in the MTOS. For most samples, the recommended groups are 1-8, 9-14, 16-24 and 25-75, while in very large samples or in studies specifically targeting critical patients there is a possibility to divide the last group into 25-48 and 50-75 groups, with an option for further division into 50-66 and 75 groups. Using a statistical analysis of two very large databases of trauma patients, we have found that partitioning of ISS into groups based on their association with patient mortality enables us to establish clear cut-off points for these groups. We propose that the suggested partition of ISS into severity groups would be adopted as a standard in order to have a common language when discussing injury severity. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Exploring the value and role of integrated supportive science courses in the reformed medical curriculum iMED: a mixed methods study.

PubMed

Eisenbarth, Sophie; Tilling, Thomas; Lueerss, Eva; Meyer, Jelka; Sehner, Susanne; Guse, Andreas H; Guse Nee Kurré, Jennifer

2016-04-29

Heterogeneous basic science knowledge of medical students is an important challenge for medical education. In this study, the authors aimed at exploring the value and role of integrated supportive science (ISS) courses as a novel approach to address this challenge and to promote learning basic science concepts in medical education. ISS courses were embedded in a reformed medical curriculum. The authors used a mixed methods approach including four focus groups involving ISS course lecturers and students (two each), and five surveys of one student cohort covering the results of regular student evaluations including the ISS courses across one study year. They conducted their study at the University Medical Center Hamburg-Eppendorf between December 2013 and July 2014. Fourteen first-year medical students and thirteen ISS course lecturers participated in the focus groups. The authors identified several themes focused on the temporal integration of ISS courses into the medical curriculum, the integration of ISS course contents into core curriculum contents, the value and role of ISS courses, and the courses' setting and atmosphere. The integrated course concept was positively accepted by both groups, with participants suggesting that it promotes retention of basic science knowledge. Values and roles identified by focus group participants included promotion of basic understanding of science concepts, integration of foundational and applied learning, and maximization of students' engagement and motivation. Building close links between ISS course contents and the core curriculum appeared to be crucial. Survey results confirmed qualitative findings regarding students' satisfaction, with some courses still requiring optimization. Integration of supportive basic science courses, traditionally rather part of premedical education, into the medical curriculum appears to be a feasible strategy to improve medical students' understanding of basic science concepts and to increase their motivation and engagement.

Detection of Iss and Bor on the surface of Escherichia coli.

PubMed

Lynne, A M; Skyberg, J A; Logue, C M; Nolan, L K

2007-03-01

To confirm the presence of Iss and Bor on the outer membrane of Escherichia coli using Western blots of outer membrane protein (OMP) preparations and fluorescence microscopy, and explore the use of fluorescence microscopy for the detection of avian pathogenic E. coli (APEC) and diagnosis of avian colibacillosis. Knockout mutants of iss and bor were created using a one-step recombination of target genes with PCR-generated antibiotic resistance cassettes. Anti-Iss monoclonal antibodies (Mabs) that cross-react with Bor protein were used to study the mutants relative to the wild-type organism. These Mabs were used as reagents to study OMP preparations of the mutants with Western blotting and intact E. coli cells with fluorescence microscopy. Iss and Bor were detected in Western blots of OMP preparations of the wild type. Also, Iss was detected on Deltabor mutants, and Bor was detected on Deltaiss mutants. Iss and Bor were also detected on the surface of the intact, wild-type cells and mutants using fluorescence microscopy. These results demonstrate that Bor and Iss are exposed on E. coli's outer membrane where they may be recognized by the host's immune system. To our knowledge, this is the first report confirming Iss' location in the outer membrane of an E. coli isolate. Such surface exposure has implications for the use of these Mabs for APEC detection and colibacillosis control.

Microbiomes of the dust particles collected from the International Space Station and Spacecraft Assembly Facilities.

PubMed

Checinska, Aleksandra; Probst, Alexander J; Vaishampayan, Parag; White, James R; Kumar, Deepika; Stepanov, Victor G; Fox, George E; Nilsson, Henrik R; Pierson, Duane L; Perry, Jay; Venkateswaran, Kasthuri

2015-10-27

The International Space Station (ISS) is a unique built environment due to the effects of microgravity, space radiation, elevated carbon dioxide levels, and especially continuous human habitation. Understanding the composition of the ISS microbial community will facilitate further development of safety and maintenance practices. The primary goal of this study was to characterize the viable microbiome of the ISS-built environment. A second objective was to determine if the built environments of Earth-based cleanrooms associated with space exploration are an appropriate model of the ISS environment. Samples collected from the ISS and two cleanrooms at the Jet Propulsion Laboratory (JPL, Pasadena, CA) were analyzed by traditional cultivation, adenosine triphosphate (ATP), and propidium monoazide-quantitative polymerase chain reaction (PMA-qPCR) assays to estimate viable microbial populations. The 16S rRNA gene Illumina iTag sequencing was used to elucidate microbial diversity and explore differences between ISS and cleanroom microbiomes. Statistical analyses showed that members of the phyla Actinobacteria, Firmicutes, and Proteobacteria were dominant in the samples examined but varied in abundance. Actinobacteria were predominant in the ISS samples whereas Proteobacteria, least abundant in the ISS, dominated in the cleanroom samples. The viable bacterial populations seen by PMA treatment were greatly decreased. However, the treatment did not appear to have an effect on the bacterial composition (diversity) associated with each sampling site. The results of this study provide strong evidence that specific human skin-associated microorganisms make a substantial contribution to the ISS microbiome, which is not the case in Earth-based cleanrooms. For example, Corynebacterium and Propionibacterium (Actinobacteria) but not Staphylococcus (Firmicutes) species are dominant on the ISS in terms of viable and total bacterial community composition. The results obtained will facilitate future studies to determine how stable the ISS environment is over time. The present results also demonstrate the value of measuring viable cell diversity and population size at any sampling site. This information can be used to identify sites that can be targeted for more stringent cleaning. Finally, the results will allow comparisons with other built sites and facilitate future improvements on the ISS that will ensure astronaut health.

Impairments as measured by ISS do not greatly change between one and eight years after CRPS 1 diagnosis.

PubMed

Vaneker, Michiel; Wilder-Smith, Oliver H G; Schrombges, Patrick; Oerlemans, H Margreet

2006-10-01

Complex Regional Pain Syndrome type 1 (CRPS 1) is a potentially incapacitating complication in which pain seems to be the most disabling factor. We performed a late follow up study of a well-defined CRPS 1 population more than eight years after diagnosis. The relationships between early and late impairments were studied with a view to outcome prediction and to investigate possible differences in long-term impairments according to initial CRPS 1 subdiagnosis (i.e. "warm" or "cold", diagnosed according to skin temperature measured via infrared thermometer). We again measured patients using the Impairment Level SumScore (ISS) (T8). These data were compared with earlier ISS measurements at CRPS diagnosis (T0) and after one year's treatment (T1). Correlations were determined between these measures. Forty-five patients participated in the present study. Total median ISS improved by 55% (statistically/clinically significant) after one year's treatment (T1), and worsened (non-significantly) by 14% from T1 to T8 - without differences according to original subdiagnosis. ISS correlations were stronger for T1 vs. T8 than for T0 vs. T1 or T0 vs. T8, being strongest for the ISS factors related to pain. Considerable impairments, as measured by ISS, are still present over eight years after first CRPS 1 diagnosis. These do not greatly change between one and eight years post-diagnosis. ISS outcomes are similar for "cold" and "warm" CRPS 1 diagnostic subgroups. Component ISS scores associated with pain appear to possess greatest predictive power.

Microbial Existence in Controlled Habitats and Their Resistance to Space Conditions

PubMed Central

Venkateswaran, Kasthuri; La Duc, Myron T.; Horneck, Gerda

2014-01-01

The National Research Council (NRC) has recently recognized the International Space Station (ISS) as uniquely suitable for furthering the study of microbial species in closed habitats. Answering the NRC’s call for the study, in particular, of uncommon microbial species in the ISS, and/or of those that have significantly increased or decreased in number, space microbiologists have begun capitalizing on the maturity, speed, and cost-effectiveness of molecular/genomic microbiological technologies to elucidate changes in microbial populations in the ISS and other closed habitats. Since investigators can only collect samples infrequently from the ISS itself due to logistical reasons, Earth analogs, such as spacecraft-assembly clean rooms, are used and extensively characterized for the presence of microbes. Microbiologists identify the predominant, problematic, and extremophilic microbial species in these closed habitats and use the ISS as a testbed to study their resistance to extreme extraterrestrial environmental conditions. Investigators monitor the microbes exposed to the real space conditions in order to track their genomic changes in response to the selective pressures present in outer space (external to the ISS) and the spaceflight (in the interior of the ISS). In this review, we discussed the presence of microbes in space research-related closed habitats and the resistance of some microbial species to the extreme environmental conditions of space. PMID:25130881

Microbial existence in controlled habitats and their resistance to space conditions.

PubMed

Venkateswaran, Kasthuri; La Duc, Myron T; Horneck, Gerda

2014-09-17

The National Research Council (NRC) has recently recognized the International Space Station (ISS) as uniquely suitable for furthering the study of microbial species in closed habitats. Answering the NRC's call for the study, in particular, of uncommon microbial species in the ISS, and/or of those that have significantly increased or decreased in number, space microbiologists have begun capitalizing on the maturity, speed, and cost-effectiveness of molecular/genomic microbiological technologies to elucidate changes in microbial populations in the ISS and other closed habitats. Since investigators can only collect samples infrequently from the ISS itself due to logistical reasons, Earth analogs, such as spacecraft-assembly clean rooms, are used and extensively characterized for the presence of microbes. Microbiologists identify the predominant, problematic, and extremophilic microbial species in these closed habitats and use the ISS as a testbed to study their resistance to extreme extraterrestrial environmental conditions. Investigators monitor the microbes exposed to the real space conditions in order to track their genomic changes in response to the selective pressures present in outer space (external to the ISS) and the spaceflight (in the interior of the ISS). In this review, we discussed the presence of microbes in space research-related closed habitats and the resistance of some microbial species to the extreme environmental conditions of space.

Investigating the Response and Expansion of Plasma Plumes in a Mesosonic Plasma Using the Situational Awareness Sensor Suite for the ISS (SASSI)

NASA Technical Reports Server (NTRS)

Gilchrist, Brian E.; Hoegy, W. R.; Krause, L. Habash; Minow, J. I.; Coffey, V. N.

2014-01-01

To study the complex interactions between the space environment surrounding the International Space Station (ISS) and the ISS space vehicle, we are exploring a specialized suite of plasma sensors, manipulated by the Space Station Remote Manipulator System (SSRMS) to probe the near-ISS mesosonic plasma ionosphere moving past the ISS. It is proposed that SASSI consists of the NASA Marshall Space Flight Center's (MSFC's) Thermal Ion Capped Hemispherical Spectrometer (TICHS), Thermal Electron Capped Hemispherical Spectrometer (TECHS), Charge Analyzer Responsive to Local Oscillations (CARLO), the Collimated PhotoElectron Gun (CPEG), and the University of Michigan Advanced Langmuir Probe (ALP). There are multiple expected applications for SASSI. Here, we will discuss the study of fundamental plasma physics questions associated with how an emitted plasma plume (such as from the ISS Plasma Contactor Unit (PCU)) responds and expands in a mesosonic magnetoplasma as well as emit and collect current. The ISS PCU Xe plasma plume drifts through the ionosphere and across the Earth's magnetic field, resulting in complex dynamics. This is of practical and theoretical interest pertaining to contamination concerns (e.g. energetic ion scattering) and the ability to collect and emit current between the spacecraft and the ambient plasma ionosphere. This impacts, for example, predictions of electrodynamic tether current performance using plasma contactors as well as decisions about placing high-energy electric propulsion thrusters on ISS. We will discuss the required measurements and connection to proposed instruments for this study.

Opportunities for Utilizing the International Space Station for Studies of F2- Region Plasma Science and High Voltage Solar Array Interactions with the Plasma Environment

NASA Technical Reports Server (NTRS)

Minow, Joseph I.; Coffey, Victoria; Wright, Kenneth; Craven, Paul; Koontz, Steven

2010-01-01

The near circular, 51.6deg inclination orbit of the International Space Station (ISS) is maintained within an altitude range of approximately 300 km to 400 km providing an ideal platform for conducting in-situ studies of space weather effects on the mid and low-latitude F-2 region ionosphere. The Floating Potential Measurement Unit (FPMU) is a suite of instruments installed on the ISS in August 2006 which includes a Floating Potential Probe (FPP), a Plasma Impedance Probe (PIP), a Wide-sweep Langmuir Probe (WLP), and a Narrow-sweep Langmuir Probe (NLP). The primary purpose for deploying the FPMU is to characterize ambient plasma temperatures and densities in which the ISS operates and to obtain measurements of the ISS potential relative to the space plasma environment for use in characterizing and mitigating spacecraft charging hazards to the vehicle and crew. In addition to the engineering goals, data from the FPMU instrument package is available for collaborative multi-satellite and ground based instrument studies of the F-region ionosphere during both quiet and disturbed periods. Finally, the FPMU measurements supported by ISS engineering telemetry data provides a unique opportunity to investigate interactions of the ISS high voltage (160 volt) solar array system with the plasma environment. This presentation will provide examples of FPMU measurements along the ISS orbit including night-time equatorial plasma density depletions sampled near the peak electron density in the F2-region ionosphere, charging phenomenon due to interaction of the ISS solar arrays with the plasma environment, and modification of ISS charging due to visiting vehicles demonstrating the capabilities of the FPMU probes for monitoring mid and low latitude plasma processes as well as vehicle interactions with the plasma environment.

Interplanetary Transit Simulations Using the International Space Station

NASA Technical Reports Server (NTRS)

Charles, John B.; Arya, M.; Kundrot, C. E.

2010-01-01

We evaluated the space life sciences utility of the International Space Station (ISS) to simulate the outbound transit portion of missions to Mars and Near Earth Asteroids (NEA) to investigate biomedical and psychological aspects of such transits, to develop and test space operation procedures compatible with communication delays and outages, and to demonstrate and validate technologies and countermeasures. Two major categories of space life sciences activities can capitalize on ISS capabilities. The first includes studies that require ISS (or a comparable facility), typically for access to prolonged weightlessness. The second includes studies that do not strictly require ISS but can exploit it to maximize their scientific return more efficiently and productively than in ground-based simulations. For these studies, ISS offers a high fidelity analog for fundamental factors on future missions, such as crew composition, mission control personnel, operational tasks and workload, real-world risk, and isolation, and can mimic the effects of distance and limited accessibility. In addition to conducting Mars- and NEA-transit simulations on 6-month ISS increments, extending the current ISS increment duration from 6 months to 9 or even 12 months will provide opportunities for enhanced and focused research relevant to long duration Mars and NEA missions. Increasing the crew duration may pose little additional risk to crewmembers beyond that currently accepted on 6-month increments, but additional medical monitoring capabilities will be required beyond those currently used for ISS operations. Finally, while presenting major logistical challenges, such a simulation followed by a post-landing simulation of Mars exploration could provide quantitative evidence of capabilities in an actual mission. Thus, the use of ISS to simulate aspects of Mars and NEA missions seems practical. If it were to be implemented without major disruption of on-going ISS activities, then planning should begin soon, in close consultation with all international partners.

Mortality following helicopter versus ground transport of injured children.

PubMed

Polites, Stephanie F; Zielinski, Martin D; Fahy, Aodhnait S; Wagie, Amy E; Moir, Christopher R; Jenkins, Donald H; Zietlow, Scott P; Habermann, Elizabeth B

2017-05-01

Injured children may be transported to trauma centers by helicopter air ambulance (HAA); however, a benefit in outcomes to this expensive resource has not been consistently shown in the literature and there is concern that HAA is over-utilized. A study that adequately controls for selection biases in transport mode is needed to determine which injured children benefit from HAA. The purpose of this study was to determine if HAA impacts mortality differently in minimally and severely injured children and if there are predictors of over-triage of HAA in children that can be identified. Children ≤18 years of age transported by HAA or ground ambulance (GA) from scene to a trauma center were identified from the 2010-2011 National Trauma Data Bank. Analysis was stratified by Injury Severity Score (ISS) into low ISS (≤15) and high ISS (>15) groups. Following propensity score matching of HAA to GA patients, conditional multivariable logistic regression was performed to determine if transport mode independently impacted mortality in each stratum. Rates and predictors of over-triage of HAA were also determined. Transport by HAA occurred in 8218 children (5574 low ISS, 2644 high ISS) and by GA in 35305 (30506 low ISS, 4799 high ISS). Overall mortality was greater in HAA patients (4.0 vs 1.4%, p<0.001). After propensity score matching, mortality was equivalent between HAA and GA for low ISS patients (0.2 vs 0.2%, p=0.82) but, for high ISS patients, mortality was lower in HAA (9.0 vs 11.1% p=0.014). On multivariable analysis, HAA was associated with decreased mortality in high ISS patients (OR=0.66, p=0.017) but not in low ISS patients (OR=1.13, p=0.73). Discharge within 24h of HAA transport occurred in 36.5% of low ISS patients versus 7.4% high ISS patients (p<0.001). Based on a national cohort adjusted for nonrandom assignment of transport mode, a survival benefit to HAA transport exists only for severely injured children with ISS >15. Many children with minor injuries are transported by helicopter despite frequent dismissal within 24h and no mortality benefit. Copyright © 2016 Elsevier Ltd. All rights reserved.

Recombinant Iss as a potential vaccine for avian colibacillosis.

PubMed

Lynne, Aaron M; Kariyawasam, Subhashinie; Wannemuehler, Yvonne; Johnson, Timothy J; Johnson, Sara J; Sinha, Avanti S; Lynne, Dorie K; Moon, Harley W; Jordan, Dianna M; Logue, Catherine M; Foley, Steven L; Nolan, Lisa K

2012-03-01

Avian pathogenic Escherichia coli (APEC) cause colibacillosis, a disease which is responsible for significant losses in poultry. Control of colibacillosis is problematic due to the restricted availability of relevant antimicrobial agents and to the frequent failure of vaccines to protect against the diverse range of APEC serogroups causing disease in birds. Previously, we reported that the increased serum survival gene (iss) is strongly associated with APEC strains, but not with fecal commensal E. coli in birds, making iss and the outer membrane protein it encodes (Iss) candidate targets for colibacillosis control procedures. Preliminary studies in birds showed that their immunization with Iss fusion proteins protected against challenge with two of the more-commonly occurring APEC serogroups (O2 and O78). Here, the potential of an Iss-based vaccine was further examined by assessing its effectiveness against an additional and widely occurring APEC serogroup (O1) and its ability to evoke both a serum and mucosal antibody response in immunized birds. In addition, tissues of selected birds were subjected to histopathologic examination in an effort to better characterize the protective response afforded by immunization with this vaccine. Iss fusion proteins were administered intramuscularly to four groups of 2-wk-old broiler chickens. At 2 wk postimmunization, chickens were challenged with APEC strains of the O1, O2, or O78 serogroups. One week after challenge, chickens were euthanatized, necropsied, any lesions consistent with colibacillosis were scored, and tissues from these birds were taken aseptically. Sera were collected pre-immunization, postimmunization, and post-challenge, and antibody titers to Iss were determined by enzyme-linked immunosorbent assay (ELISA). Also, air sac washings were collected to determine the mucosal antibody response to Iss by ELISA. During the observation period following challenge, 3/12 nonimmunized chickens, 1/12 chickens immunized with 10 microg of GST-Iss, and 1/12 chickens immunized with 50 microg of GST-Iss died when challenged with the O78 strain. No other deaths occurred. Immunized chickens produced a serum and mucosal antibody response to Iss and had significantly lower lesion scores than nonimmunized chickens following challenge, regardless of the challenge strain. This study expands on our previous report of the value of Iss as an immunoprotective antigen and demonstrates that immunization with Iss can provide significant protection of chickens against challenge with three different E. coli strains.

The Future of New Discoveries on the International Space Station

NASA Technical Reports Server (NTRS)

Schlagheck, Ronald; Trach, Brian

2000-01-01

The Materials Science program is one of the five Microgravity research disciplines in NASA's Human Exploration and Development of Space (HEDS). This research uses the low gravity environment to obtain the fundamental understanding of various phenomena effects and it's relationship to structure, processing, and properties of materials. The International Space Station (ISS) will complete the first major assembly phase within the next year thus providing the opportunity for on-orbit research and scientific utilization in early 2001. Research will become routine as the final Space Station configuration is completed. Accommodations will support a variety of Materials Science payload hardware both in the US and international partner modules. This paper addresses the current scope of the flight investigator program that will utilize the various capabilities on ISS. The type of research and classification of materials that are addressed using multiple types of flight apparatus will be explained. The various flight and ground facilities that are used to support the NASA program are described. The early utilization schedule for the materials science payloads with associated hardware will be covered. The Materials Science Research Facility and related international experiment modules serves as the foundation for this capability. The potential applications and technologies obtained from the Materials Science program are described.

Clarifying the learning experiences of healthcare professionals with in situ and off-site simulation-based medical education: a qualitative study

PubMed Central

Sørensen, Jette Led; Navne, Laura Emdal; Martin, Helle Max; Ottesen, Bent; Albrecthsen, Charlotte Krebs; Pedersen, Berit Woetmann; Kjærgaard, Hanne; van der Vleuten, Cees

2015-01-01

Objective To examine how the setting in in situ simulation (ISS) and off-site simulation (OSS) in simulation-based medical education affects the perceptions and learning experience of healthcare professionals. Design Qualitative study using focus groups and content analysis. Participants Twenty-five healthcare professionals (obstetricians, midwives, auxiliary nurses, anaesthesiologists, a nurse anaesthetist and operating theatre nurse) participated in four focus groups and were recruited due to their exposure to either ISS or OSS in multidisciplinary obstetric emergencies in a randomised trial. Setting Departments of obstetrics and anaesthesia, Rigshospitalet, Copenhagen, Denmark. Results Initially participants preferred ISS, but this changed after the training when the simulation site became of less importance. There was a strong preference for simulation in authentic roles. These perceptions were independent of the ISS or OSS setting. Several positive and negative factors in simulation were identified, but these had no relation to the simulation setting. Participants from ISS and OSS generated a better understanding of and collaboration with the various health professionals. They also provided individual and team reflections on learning. ISS participants described more experiences that would involve organisational changes than the OSS participants did. Conclusions Many psychological and sociological aspects related to the authenticity of the learning experience are important in simulation, but the physical setting of the simulation as an ISS and OSS is the least important. Based on these focus groups OSS can be used provided that all other authenticity elements are taken into consideration and respected. The only difference was that ISS had an organisational impact and ISS participants talked more about issues that would involve practical organisational changes. ISS and OSS participants did, however, go through similar individual and team learning experiences. PMID:26443655

Evolution of the iss gene in Escherichia coli.

PubMed

Johnson, Timothy J; Wannemuehler, Yvonne M; Nolan, Lisa K

2008-04-01

The increased serum survival gene iss has long been recognized for its role in extraintestinal pathogenic Escherichia coli (ExPEC) virulence. iss has been identified as a distinguishing trait of avian ExPEC but not of human ExPEC. This gene has been localized to large virulence plasmids and shares strong similarities with the bor gene from bacteriophage lambda. Here, we demonstrate that three alleles of iss occur among E. coli isolates that appear to have evolved from a common lambda bor precursor. In addition to the occurrence of iss on the ColV/BM virulence plasmids, at least two iss alleles occur within the E. coli chromosome. One of these alleles (designated type 3) was found to occur in the genomes of all currently sequenced ExPEC strains on a similar prophage element that also harbors the Sit iron and manganese transport system. When the prevalence of the three iss types was examined among 487 E. coli isolates, the iss type 3 gene was found to occur at a high frequency among ExPEC isolates, irrespective of the host source. The plasmid-borne iss allele (designated type 1) was highly prevalent among avian pathogenic E. coli and neonatal meningitis-associated E. coli isolates but not among uropathogenic E. coli isolates. This study demonstrates the evolution of iss in E. coli and provides an additional tool for discriminating among E. coli pathotypes through the differentiation of the three iss allele types and bor.

Validity of Soccer Injury Data from the National Collegiate Athletic Association's Injury Surveillance System

PubMed Central

Kucera, Kristen L.; Marshall, Stephen W.; Bell, David R.; DiStefano, Michael J.; Goerger, Candice P.; Oyama, Sakiko

2011-01-01

Context: Few validation studies of sport injury-surveillance systems are available. Objective: To determine the validity of a Web-based system for surveillance of collegiate sport injuries, the Injury Surveillance System (ISS) of the National Collegiate Athletic Association's (NCAA). Design: Validation study comparing NCAA ISS data from 2 fall collegiate sports (men's and women's soccer) with other types of clinical records maintained by certified athletic trainers. Setting: A purposive sample of 15 NCAA colleges and universities that provided NCAA ISS data on both men's and women's soccer for at least 2 years during 2005–2007, stratified by playing division. Patients or Other Participants: A total of 737 men's and women's soccer athletes and 37 athletic trainers at these 15 institutions. Main Outcome Measure(s): The proportion of injuries captured by the NCAA ISS (capture rate) was estimated by comparing NCAA ISS data with the other clinical records on the same athletes maintained by the athletic trainers. We reviewed all athletic injury events resulting from participation in NCAA collegiate sports that resulted in 1 day or more of restricted activity in games or practices and necessitated medical care. A capture-recapture analysis estimated the proportion of injury events captured by the NCAA ISS. Agreement for key data fields was also measured. Results: We analyzed 664 injury events. The NCAA ISS captured 88.3% (95% confidence interval = 85.9%, 90.8%) of all time-lost medical-attention injury events. The proportion of injury events captured by the NCAA ISS was higher in Division I (93.8%) and Division II (89.6%) than in Division III (82.3%) schools. Agreement between the NCAA ISS data and the non–NCAA ISS data was good for the majority of data fields but low for date of full return and days lost from sport participation. Conclusions: The overall capture rate of the NCAA ISS was very good (88%) in men's and women's soccer for this period. PMID:22488136

Defining major trauma using the 2008 Abbreviated Injury Scale.

PubMed

Palmer, Cameron S; Gabbe, Belinda J; Cameron, Peter A

2016-01-01

The Injury Severity Score (ISS) is the most ubiquitous summary score derived from Abbreviated Injury Scale (AIS) data. It is frequently used to classify patients as 'major trauma' using a threshold of ISS >15. However, it is not known whether this is still appropriate, given the changes which have been made to the AIS codeset since this threshold was first used. This study aimed to identify appropriate ISS and New Injury Severity Score (NISS) thresholds for use with the 2008 AIS (AIS08) which predict mortality and in-hospital resource use comparably to ISS >15 using AIS98. Data from 37,760 patients in a state trauma registry were retrieved and reviewed. AIS data coded using the 1998 AIS (AIS98) were mapped to AIS08. ISS and NISS were calculated, and their effects on patient classification compared. The ability of selected ISS and NISS thresholds to predict mortality or high-level in-hospital resource use (the need for ICU or urgent surgery) was assessed. An ISS >12 using AIS08 was similar to an ISS >15 using AIS98 in terms of both the number of patients classified major trauma, and overall major trauma mortality. A 10% mortality level was only seen for ISS 25 or greater. A NISS >15 performed similarly to both of these ISS thresholds. However, the AIS08-based ISS >12 threshold correctly classified significantly more patients than a NISS >15 threshold for all three severity measures assessed. When coding injuries using AIS08, an ISS >12 appears to function similarly to an ISS >15 in AIS98 for the purposes of identifying a population with an elevated risk of death after injury. Where mortality is a primary outcome of trauma monitoring, an ISS >12 threshold could be adopted to identify major trauma patients. Level II evidence--diagnostic tests and criteria. Copyright © 2015 Elsevier Ltd. All rights reserved.

End-Point Variability Is Not Noise in Saccade Adaptation

PubMed Central

Herman, James P.; Cloud, C. Phillip; Wallman, Josh

2013-01-01

When each of many saccades is made to overshoot its target, amplitude gradually decreases in a form of motor learning called saccade adaptation. Overshoot is induced experimentally by a secondary, backwards intrasaccadic target step (ISS) triggered by the primary saccade. Surprisingly, however, no study has compared the effectiveness of different sizes of ISS in driving adaptation by systematically varying ISS amplitude across different sessions. Additionally, very few studies have examined the feasibility of adaptation with relatively small ISSs. In order to best understand saccade adaptation at a fundamental level, we addressed these two points in an experiment using a range of small, fixed ISS values (from 0° to 1° after a 10° primary target step). We found that significant adaptation occurred across subjects with an ISS as small as 0.25°. Interestingly, though only adaptation in response to 0.25° ISSs appeared to be complete (the magnitude of change in saccade amplitude was comparable to size of the ISS), further analysis revealed that a comparable proportion of the ISS was compensated for across conditions. Finally, we found that ISS size alone was sufficient to explain the magnitude of adaptation we observed; additional factors did not significantly improve explanatory power. Overall, our findings suggest that current assumptions regarding the computation of saccadic error may need to be revisited. PMID:23555763

Effect of growth hormone treatment on craniofacial growth in children: Idiopathic short stature versus growth hormone deficiency.

PubMed

Choi, Sung-Hwan; Fan, Dong; Hwang, Mi-Soo; Lee, Hee-Kyung; Hwang, Chung-Ju

2017-04-01

Few studies have evaluated craniofacial growth in boys and girls with idiopathic short stature (ISS) during growth hormone (GH) treatment. The aim of this study was to evaluate the effect of GH treatment on craniofacial growth in children with ISS, compared with those with growth hormone deficiency (GHD). This study included 36 children (mean age, 11.3 ± 1.8 years) who were treated with GH consecutively. Lateral cephalograms were analyzed before and 2 years after start of GH treatment. There were no significant differences in age and sex between ISS and GHD groups and the reference group from semilongitudinal study (10 boys and 8 girls from each group). Before treatment, girls with ISS showed a skeletal Class II facial profile compared with the GHD and reference groups (p = 0.003). During GH treatment, the amount of maxillary length increased beyond norm in the ISS and GHD groups in boys (p = 0.035) > 3 standard deviation score (SDS). Meanwhile, mandibular ramus height (p = 0.001), corpus length, and total mandibular length (p = 0.007 for both) increased more in girls with ISS than in girls with GHD. Lower and total anterior facial heights increased more in girls with ISS than in girls with GHD (p = 0.021 and p = 0.007, respectively), > 7-11 SDS. GH should be administered carefully when treating girls with ISS, because GH treatment has great effects on vertical overgrowth of the mandible and can result in longer face. Copyright © 2016. Published by Elsevier B.V.

Immune response to recombinant Escherichia coli Iss protein in poultry.

PubMed

Lynne, Aaron M; Foley, Steven L; Nolan, Lisa K

2006-06-01

Colibacillosis accounts for significant losses to the poultry industry, and control efforts are hampered by limited understanding of the mechanisms used by avian pathogenic Escherichia coli (APEC) to cause disease. We have found that the presence of the increased serum survival gene (iss) is strongly associated with APEC but not with commensal E. coli, making iss, and the protein it encodes (Iss), candidate targets of colibacillosis control procedures. To assess the potential of Iss to elicit a protective response in chickens against APEC challenge, Iss fusion proteins were produced and administered subcutaneously to four groups of 2-wk-old specific-pathogen-free leghorn chickens. At 4 wk postimmunization, birds were challenged with APEC from serogroups 02 and 078 via intramuscular injection. At 2 wk postchallenge, birds were necropsied, and lesions consistent with colibacillosis were scored. Also, sera were collected from the birds pre- and postimmunization, and antibody titers to Iss were determined. Immunized birds produced a humoral response to Iss, and they had significantly lower lesion scores than the unimmunized control birds following challenge with both APEC strains. Birds that received the smallest amount of immunogen had the lowest lesion scores. Although further study will be needed to confirm the value of Iss as an immunoprotective antigen, these preliminary data suggest that Iss may have the potential to elicit significant protection in birds against heterologous E. coli challenge.

The effect of growth hormone treatment on height in children with idiopathic short stature.

PubMed

Jeong, Hwal Rim; Shim, Young Seok; Lee, Hae Sang; Hwang, Jin Soon

2014-07-01

Idiopathic short stature (ISS) is short stature of unknown cause. In 2003, the Food and Drug Administration (FDA) approved the use of growth hormone (GH) for ISS. Several studies have evaluated the effect of GH in children with ISS, in whom improved growth velocities and height standard deviation scores (SDS) have been reported. However, clinical variables influence the height improvement. This study aimed to evaluate the effects of GH treatment on ISS and to analyze clinical factors associated with growth velocity. This study was conducted retrospectively. Subjects diagnosed with ISS at Ajou University Hospital were divided into two groups, an ISS with GH-treatment group (n=34) and an ISS control group (n=36). All children were prepubertal, and aged <10 years. We reviewed their auxological data, laboratory findings, and bone age. Growth velocity of the GH-treatment group exceeded that of controls by 3.37 cm/year (95% CI, 2.78-3.95). At baseline, the mean SDS for height in the treatment and control groups were equivalent (-2.25 ± 0.29 and -2.22 ± 0.31, respectively). However, after 1 year, the height of the GH-treated group exceeded that of the control group by 0.73 SDS (95% CI, 0.57-0.88). A negative correlation was found between age and growth velocity in the GH-treatment group. GH treatment increased short-term growth velocity and height SDS of Korean children with ISS. Age was identified as the single most important factor correlated with growth velocity in GH treatment.

The Effect of Inschool Suspension on the Academic Progress of High School Science and English Students.

ERIC Educational Resources Information Center

Silvey, Donald F.

This paper presents findings of a study that explored the effects of assignment to an inschool suspension (ISS) program on high school students' academic performance. The study compared the before- and after-ISS grades in English and science of 32 ninth- and tenth-grade students who had spent a minimum of 5 days in an ISS program during a 6-week…

International Space Station (ISS) Plasma Contactor Unit (PCU) Utilization Plan Assessment Update

NASA Technical Reports Server (NTRS)

Hernandez-Pellerano, Amri; Iannello, Christopher J.; Garrett, Henry B.; Ging, Andrew T.; Katz, Ira; Keith, R. Lloyd; Minow, Joseph I.; Willis, Emily M.; Schneider, Todd A.; Whittlesey, Edward J.;

Integration Assessment of Visiting Vehicle Induced Electrical Charging of the International Space Station Structure

NASA Technical Reports Server (NTRS)

Kramer, Leonard; Kerslake, Thomas W.; Galofaro, Joel T.

2010-01-01

The International Space Station (ISS) undergoes electrical charging in low Earth orbit (LEO) due to positively biased, exposed conductors on solar arrays that collect electrical charges from the space plasma. Exposed solar array conductors predominately collect negatively charged electrons and thus drive the metal ISS structure electrical ground to a negative floating potential (FP) relative to plasma. This FP is variable in location and time as a result of local ionospheric conditions. ISS motion through Earth s magnetic field creates an addition inductive voltage up to 20 positive and negative volts across ISS structure depending on its attitude and location in orbit. ISS Visiting Vehicles (VVs), such as the planned Orion crew exploration vehicle, contribute to the ISS plasma charging processes. Upon physical contact with ISS, the current collection properties of VVs combine with ISS. This is an ISS integration concern as FP must be controlled to minimize arcing of ISS surfaces and ensure proper management of extra vehicular activity crewman shock hazards. This report is an assessment of ISS induced charging from docked Orion vehicles employing negatively grounded, 130 volt class, UltraFlex (ATK Space Systems) solar arrays. To assess plasma electron current collection characteristics, Orion solar cell test coupons were constructed and subjected to plasma chamber current collection measurements. During these tests, coupon solar cells were biased between 0 and 120 V while immersed in a simulated LEO plasma. Tests were performed using several different simulated LEO plasma densities and temperatures. These data and associated theoretical scaling of plasma properties, were combined in a numerical model which was integrated into the Boeing Plasma Interaction Model. It was found that the solar array design for Orion will not affect the ISS FP by more than about 2 V during worst case charging conditions. This assessment also motivated a trade study to determine acceptable plasma electron current levels that can be collected by a single or combined fleet of ISS-docked VVs.

An Evaluation of In-School Suspension Programs.

ERIC Educational Resources Information Center

Siskind, Theresa G.; And Others

Findings of a study that determined the effectiveness of the Berkeley County (South Carolina) in-school suspension (ISS) program are presented in this paper. Methodology involved personal interviews conducted with the ISS director and ISS teacher in 8 middle and 8 high schools in the county, a total of 16 principals and 16 teachers. Findings…

Plant Development and Genetics Experiment

NASA Technical Reports Server (NTRS)

2003-01-01

Aboard the International Space Station (ISS), the Russian Lada greenhouse provides home to an experiment that investigates plant development and genetics. Space grown peas have dried and 'gone to seed.' The crew of the ISS will soon harvest the seeds. Eventually some will be replanted onboard the ISS, and some will be returned to Earth for further study.

Optimizing the utility of military injury surveillance systems: a qualitative study within the Australian Defence Force.

PubMed

McKinnon, Adam D; Ozanne-Smith, Joan; Pope, Rodney

2009-05-01

Injury prevention guided by robust injury surveillance systems (ISS's) can effectively reduce military injury rates, but ISS's depend on human interaction. This study examined experiences and requirements of key users of the Australian Defence Force (ADF) ISS to determine whether the operation of the ISS was optimal, whether there were any shortcomings, and if so, how these shortcomings might be addressed. Semistructured interviews were conducted with 18 Australian Defence Department participants located throughout Australia. Grounded theory methods were used to analyze data by developing an understanding of processes and social phenomena related to injury surveillance systems within the military context. Interviews were recorded and professionally transcribed and information contained in the transcripts was analyzed using NVivo. Key themes relating to the components of an injury surveillance system were identified from the analysis. A range of processes and sociocultural factors influence the utility of military ISS's. These are discussed in detail and should be considered in the future design and operation of military ISS's to facilitate optimal outcomes for injury prevention.

Mid-Latitude Ionospheric Disturbances Due to Geomagnetic Storms at ISS Altitudes

NASA Technical Reports Server (NTRS)

Minow, Joseph I.; Willis, Emily M.; Parker, Linda Neergaard

2014-01-01

Spacecraft charging of the International Space Station (ISS) is dominated by the interaction of the high voltage US solar arrays with the F2-region ionospheric plasma environment. We are working to fully understand the charging behavior of the ISS solar arrays and determine how well future charging behavior can be predicted from in-situ measurements of plasma density and temperature. One aspect of this work is a need to characterize the magnitude of electron density and temperature variations that may be encountered at ISS orbital altitudes (approximately 400 km), the latitudes over which they occur, and the time periods for which the disturbances persist. We will present preliminary results from a study of ionospheric disturbances in the "mid-latitude" region defined as the approximately 30 - 60 degree extra-equatorial magnetic latitudes sampled by ISS. The study is focused on geomagnetic storm periods because they are well known drivers for disturbances in the high-latitude and mid-latitude ionospheric plasma. Changes in the F2 peak electron density obtained from ground based ionosonde records are compared to in-situ electron density and temperature measurements from the CHAMP and ISS spacecraft at altitudes near, or above, the F2 peak. Results from a number of geomagnetic storms will be presented and their potential impact on ISS charging will be discussed.

Survival time estimation using Injury Severity Score (ISS) in homicide cases.

PubMed

Cros, Jérôme; Alvarez, Jean-Claude; Sbidian, Emilie; Charlier, Philippe; de la Grandmaison, Geoffroy Lorin

2013-12-10

The aim of our study was to assess the value of ISS to estimate survival time in a retrospective study of all homicidal deaths in the Western suburbs of Paris between 1994 and 2008. Stab wounds were the most common cause of death. Survival time between assault and death, determined in 107 cases out of 511 homicide cases, ranged from 0 min to 25 days (mean 39 h). There was an overall significant association between the survival time and the ISS score. ISS and survival time were strongly associated with male victims and a clear trend was seen with women. Regarding the type of wounds, a trend was seen with gunshot wounds and blunt injuries, but not with stab wounds. There was no influence of blood toxicological results and resuscitation attempts. Overall, ISS was a good predictor of a survival under 30 min. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

ISS-An Electronic Syndromic Surveillance System for Infectious Disease in Rural China

PubMed Central

Yan, Weirong; Palm, Lars; Lu, Xin; Nie, Shaofa; Xu, Biao; Zhao, Qi; Tao, Tao; Cheng, Liwei; Tan, Li; Dong, Hengjin; Diwan, Vinod K.

2013-01-01

Background syndromic surveillance system has great advantages in promoting the early detection of epidemics and reducing the necessities of disease confirmation, and it is especially effective for surveillance in resource poor settings. However, most current syndromic surveillance systems are established in developed countries, and there are very few reports on the development of an electronic syndromic surveillance system in resource-constrained settings. Objective this study describes the design and pilot implementation of an electronic surveillance system (ISS) for the early detection of infectious disease epidemics in rural China, complementing the conventional case report surveillance system. Methods ISS was developed based on an existing platform ‘Crisis Information Sharing Platform’ (CRISP), combining with modern communication and GIS technology. ISS has four interconnected functions: 1) work group and communication group; 2) data source and collection; 3) data visualization; and 4) outbreak detection and alerting. Results As of Jan. 31st 2012, ISS has been installed and pilot tested for six months in four counties in rural China. 95 health facilities, 14 pharmacies and 24 primary schools participated in the pilot study, entering respectively 74256, 79701, and 2330 daily records into the central database. More than 90% of surveillance units at the study sites are able to send daily information into the system. In the paper, we also presented the pilot data from health facilities in the two counties, which showed the ISS system had the potential to identify the change of disease patterns at the community level. Conclusions The ISS platform may facilitate the early detection of infectious disease epidemic as it provides near real-time syndromic data collection, interactive visualization, and automated aberration detection. However, several constraints and challenges were encountered during the pilot implementation of ISS in rural China. PMID:23626853

ISS--an electronic syndromic surveillance system for infectious disease in rural China.

PubMed

Yan, Weirong; Palm, Lars; Lu, Xin; Nie, Shaofa; Xu, Biao; Zhao, Qi; Tao, Tao; Cheng, Liwei; Tan, Li; Dong, Hengjin; Diwan, Vinod K

2013-01-01

Syndromic surveillance system has great advantages in promoting the early detection of epidemics and reducing the necessities of disease confirmation, and it is especially effective for surveillance in resource poor settings. However, most current syndromic surveillance systems are established in developed countries, and there are very few reports on the development of an electronic syndromic surveillance system in resource-constrained settings. This study describes the design and pilot implementation of an electronic surveillance system (ISS) for the early detection of infectious disease epidemics in rural China, complementing the conventional case report surveillance system. ISS was developed based on an existing platform 'Crisis Information Sharing Platform' (CRISP), combining with modern communication and GIS technology. ISS has four interconnected functions: 1) work group and communication group; 2) data source and collection; 3) data visualization; and 4) outbreak detection and alerting. As of Jan. 31(st) 2012, ISS has been installed and pilot tested for six months in four counties in rural China. 95 health facilities, 14 pharmacies and 24 primary schools participated in the pilot study, entering respectively 74,256, 79,701, and 2330 daily records into the central database. More than 90% of surveillance units at the study sites are able to send daily information into the system. In the paper, we also presented the pilot data from health facilities in the two counties, which showed the ISS system had the potential to identify the change of disease patterns at the community level. The ISS platform may facilitate the early detection of infectious disease epidemic as it provides near real-time syndromic data collection, interactive visualization, and automated aberration detection. However, several constraints and challenges were encountered during the pilot implementation of ISS in rural China.

Diversity in immunological synapse structure

PubMed Central

Thauland, Timothy J; Parker, David C

2010-01-01

Immunological synapses (ISs) are formed at the T cell–antigen-presenting cell (APC) interface during antigen recognition, and play a central role in T-cell activation and in the delivery of effector functions. ISs were originally described as a peripheral ring of adhesion molecules surrounding a central accumulation of T-cell receptor (TCR)–peptide major histocompatibility complex (pMHC) interactions. Although the structure of these ‘classical’ ISs has been the subject of intense study, non-classical ISs have also been observed under a variety of conditions. Multifocal ISs, characterized by adhesion molecules dispersed among numerous small accumulations of TCR–pMHC, and motile ‘immunological kinapses’ have both been described. In this review, we discuss the conditions under which non-classical ISs are formed. Specifically, we explore the profound effect that the phenotypes of both T cells and APCs have on IS structure. We also comment on the role that IS structure may play in T-cell function. PMID:21039474

The Era of International Space Station Utilization Begins: Research Strategy, International Collaboration, and Realized Potential

NASA Technical Reports Server (NTRS)

Thumm, Tracy; Robinson, Julie A.; Ruttley, Tara; Johnson-Green, Perry; Karabadzhak, George; Nakamura, Tai; Sorokin, Igor V.; Zell, Martin; Jean, Sabbagh

2010-01-01

With the assembly of the International Space Station (ISS) nearing completion and the support of a full-time crew of six, a new era of utilization for research is beginning. For more than 15 years, the ISS international partnership has weathered financial, technical and political challenges proving that nations can work together to complete assembly of the largest space vehicle in history. And while the ISS partners can be proud of having completed one of the most ambitious engineering projects ever conceived, the challenge of successfully using the platform remains. During the ISS assembly phase, the potential benefits of space-based research and development were demonstrated; including the advancement of scientific knowledge based on experiments conducted in space, development and testing of new technologies, and derivation of Earth applications from new understanding. The configurability and human-tended capabilities of the ISS provide a unique platform. The international utilization strategy is based on research ranging from physical sciences, biology, medicine, psychology, to Earth observation, human exploration preparation and technology demonstration. The ability to complete follow-on investigations in a period of months allows researchers to make rapid advances based on new knowledge gained from ISS activities. During the utilization phase, the ISS partners are working together to track the objectives, accomplishments, and the applications of the new knowledge gained. This presentation will summarize the consolidated international results of these tracking activities and approaches. Areas of current research on ISS with strong international cooperation will be highlighted including cardiovascular studies, cell and plant biology studies, radiation, physics of matter, and advanced alloys. Scientific knowledge and new technologies derived from research on the ISS will be realized through improving quality of life on Earth and future spaceflight endeavours. Extension of the ISS through 2020 and beyond will insure that the benefits of research will be achievable for the International Partnership.

Tensile and shear loading of four fcc high-entropy alloys: A first-principles study

NASA Astrophysics Data System (ADS)

Li, Xiaoqing; Schönecker, Stephan; Li, Wei; Varga, Lajos K.; Irving, Douglas L.; Vitos, Levente

2018-03-01

Ab initio density-functional calculations are used to investigate the response of four face-centered-cubic (fcc) high-entropy alloys (HEAs) to tensile and shear loading. The ideal tensile and shear strengths (ITS and ISS) of the HEAs are studied by employing first-principles alloy theory formulated within the exact muffin-tin orbital method in combination with the coherent-potential approximation. We benchmark the computational accuracy against literature data by studying the ITS under uniaxial [110] tensile loading and the ISS for the [11 2 ¯] (111 ) shear deformation of pure fcc Ni and Al. For the HEAs, we uncover the alloying effect on the ITS and ISS. Under shear loading, relaxation reduces the ISS by ˜50 % for all considered HEAs. We demonstrate that the dimensionless tensile and shear strengths are significantly overestimated by adopting two widely used empirical models in comparison with our ab initio calculations. In addition, our predicted relationship between the dimensionless shear strength and shear instability are in line with the modified Frenkel model. Using the computed ISS, we derive the half-width of the dislocation core for the present HEAs. Employing the ratio of ITS to ISS, we discuss the intrinsic ductility of HEAs and compare it with a common empirical criterion. We observe a strong linear correlation between the shear instability and the ratio of ITS to ISS, whereas a weak positive correlation is found in the case of the empirical criterion.

Shuttle/ISS EMU Failure History and the Impact on Advanced EMU Portable Life Support System (PLSS) Design

NASA Technical Reports Server (NTRS)

Campbell, Colin

2015-01-01

As the Shuttle/ISS EMU Program exceeds 35 years in duration and is still supporting the needs of the International Space Station (ISS), a critical benefit of such a long running program with thorough documentation of system and component failures is the ability to study and learn from those failures when considering the design of the next generation space suit. Study of the subject failure history leads to changes in the Advanced EMU Portable Life Support System (PLSS) schematic, selected component technologies, as well as the planned manner of ground testing. This paper reviews the Shuttle/ISS EMU failure history and discusses the implications to the AEMU PLSS.

Shuttle/ISS EMU Failure History and the Impact on Advanced EMU PLSS Design

NASA Technical Reports Server (NTRS)

Campbell, Colin

2011-01-01

As the Shuttle/ISS EMU Program exceeds 30 years in duration and is still successfully supporting the needs of the International Space Station (ISS), a critical benefit of such a long running program with thorough documentation of system and component failures is the ability to study and learn from those failures when considering the design of the next generation space suit. Study of the subject failure history leads to changes in the Advanced EMU Portable Life Support System (PLSS) schematic, selected component technologies, as well as the planned manner of ground testing. This paper reviews the Shuttle/ISS EMU failure history and discusses the implications to the AEMU PLSS.

Shuttle/ISS EMU Failure History and the Impact on Advanced EMU PLSS Design

NASA Technical Reports Server (NTRS)

Campbell, Colin

2015-01-01

As the Shuttle/ISS EMU Program exceeds 30 years in duration and is still supporting the needs of the International Space Station (ISS), a critical benefit of such a long running program with thorough documentation of system and component failures is the ability to study and learn from those failures when considering the design of the next generation space suit. Study of the subject failure history leads to changes in the Advanced EMU Portable Life Support System (PLSS) schematic, selected component technologies, as well as the planned manner of ground testing. This paper reviews the Shuttle/ISS EMU failure history and discusses the implications to the AEMU PLSS.

Utilizing ISS Camera Systems for Scientific Analysis of Lightning Characteristics and Comparison with ISS-LIS and GLM

NASA Technical Reports Server (NTRS)

Schultz, Christopher J.; Lang, Timothy J.; Leake, Skye; Runco, Mario, Jr.; Blakeslee, Richard J.

2017-01-01

Video and still frame images from cameras aboard the International Space Station (ISS) are used to inspire, educate, and provide a unique vantage point from low-Earth orbit that is second to none; however, these cameras have overlooked capabilities for contributing to scientific analysis of the Earth and near-space environment. The goal of this project is to study how geo referenced video/images from available ISS camera systems can be useful for scientific analysis, using lightning properties as a demonstration.

Acquisition of the Korean Imperfective Aspect Markers "-ko iss-" and "-a iss-" by Japanese Learners: A Multiple-Factor Account

ERIC Educational Resources Information Center

Ryu, Ju-Yeon; Horie, Kaoru; Shirai, Yasuhiro

2015-01-01

Although cross-linguistic research on second language tense-aspect acquisition has uncovered universal tendencies concerning the association between verbal semantics and tense-aspect markers, it is still unclear what mechanisms underlie this link. This study investigates the acquisition of two imperfective aspect markers ("-ko iss-" and…

Changing to AIS 2005 and agreement of injury severity scores in a trauma registry with scores based on manual chart review.

PubMed

Stewart, Kenneth E; Cowan, Linda D; Thompson, David M

2011-09-01

The Abbreviated Injury Scale (AIS) recently underwent a major revision from AIS 98 to AIS 05. AIS injury codes form the basis of widely used injury severity scores such as the injury severity score (ISS). ISS thresholds are often used in trauma case definitions and ISS is widely used in injury research to adjust for injury severity. This study evaluated changes from AIS 98 to AIS 05, the changes' effect on ISS distributions, and presents an application of the results. Injury descriptions from medical records of 137 randomly selected patients in the Oklahoma Trauma Registry (OTR) were obtained. A single trained coder used AIS 98 and AIS 05 to code each injury. ISS values were calculated and grouped into 4 categories: 1-8, 9-14, 16-24, >24. Paired ISS was compared using Kappa statistics and tests of symmetry. We identified common injury diagnoses for which AIS severity changed between versions. Estimates of the proportion of patients changing ISS groups were applied to the entire OTR to assess the impact on reporting and on a model for reimbursement. OTR AIS 98 and manual AIS 98-based ISS values had a weighted Kappa of 0.71. OTR AIS 98 and manual AIS 05-based ISS values had a Kappa of 0.58. Manual AIS 98 and manual AIS 05 ISS had the highest Kappa of 0.81, however, though the scores differed by only 1 ISS category, there were 30 discordant pairs. The distribution of these discordant pairs was not symmetrical (Bowker's S=30; df=6; p<0.0001) with AIS 05-based ISS values consistently shifted to a lower ISS category. Reductions in AIS severity and ISS values using AIS 05 were common for extremity fractures and thorax injuries. The results suggest fewer patients would be reported to the OTR or be eligible for reimbursement. Changing from AIS 98 to AIS 05 injury coding resulted in systematic changes in AIS codes and ISS. Specific injuries and body regions were differentially affected. Trauma registries and injury researchers that use AIS based injury coding can use this information to evaluate the potential impact of changes in AIS 2005. Copyright © 2010 Elsevier Ltd. All rights reserved.

Comparison and phylogenetic analysis of the ISS gene in two predominant avian pathogenic E. coli serogroups isolated from avian colibacillosis in Iran.

PubMed

Zahraei Salehi, Taghi; Derakhshandeh, Abdollah; Tadjbakhsh, Hasan; Karimi, Vahid

2013-02-01

The ISS (increased serum survival) gene and its protein product (ISS) of avian pathogenic Escherichia coli (APEC) are important characteristics of resistance to the complement system. The aims of this study were to clone, sequence and characterize sequence diversity of the ISS gene between two predominant serogroups in Iran and among those previously deposited in Genbank. The ISS gene of 309 bp from the APEC χ1390 strain was amplified by PCR, cloned and sequenced using pTZ57R/T vector. The ISS gene from the χ1390 strain has 100% identity among different serogroups of APEC in different geographical regions throughout the world. Phylogenetic analysis shows two different phylogenic groups among the different strains. Strong association of nucleotide sequences among different E. coli strains suggests that it may be a conserved gene and could be a suitable antigen to control and detect avian pathogenic E. coli, at least in our region. Currently, our group is working on the ISS protein as candidate vaccine in SPF poultry. Copyright © 2012 Elsevier Ltd. All rights reserved.

Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group

PubMed Central

Palumbo, Antonio; Avet-Loiseau, Hervé; Oliva, Stefania; Lokhorst, Henk M.; Goldschmidt, Hartmut; Rosinol, Laura; Richardson, Paul; Caltagirone, Simona; Lahuerta, Juan José; Facon, Thierry; Bringhen, Sara; Gay, Francesca; Attal, Michel; Passera, Roberto; Spencer, Andrew; Offidani, Massimo; Kumar, Shaji; Musto, Pellegrino; Lonial, Sagar; Petrucci, Maria T.; Orlowski, Robert Z.; Zamagni, Elena; Morgan, Gareth; Dimopoulos, Meletios A.; Durie, Brian G.M.; Anderson, Kenneth C.; Sonneveld, Pieter; San Miguel, Jésus; Cavo, Michele; Rajkumar, S. Vincent; Moreau, Philippe

2015-01-01

Purpose The clinical outcome of multiple myeloma (MM) is heterogeneous. A simple and reliable tool is needed to stratify patients with MM. We combined the International Staging System (ISS) with chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) to evaluate their prognostic value in newly diagnosed MM (NDMM). Patients and Methods Clinical and laboratory data from 4,445 patients with NDMM enrolled onto 11 international trials were pooled together. The K-adaptive partitioning algorithm was used to define the most appropriate subgroups with homogeneous survival. Results ISS, CA, and LDH data were simultaneously available in 3,060 of 4,445 patients. We defined the following three groups: revised ISS (R-ISS) I (n = 871), including ISS stage I (serum β2-microglobulin level < 3.5 mg/L and serum albumin level ≥ 3.5 g/dL), no high-risk CA [del(17p) and/or t(4;14) and/or t(14;16)], and normal LDH level (less than the upper limit of normal range); R-ISS III (n = 295), including ISS stage III (serum β2-microglobulin level > 5.5 mg/L) and high-risk CA or high LDH level; and R-ISS II (n = 1,894), including all the other possible combinations. At a median follow-up of 46 months, the 5-year OS rate was 82% in the R-ISS I, 62% in the R-ISS II, and 40% in the R-ISS III groups; the 5-year PFS rates were 55%, 36%, and 24%, respectively. Conclusion The R-ISS is a simple and powerful prognostic staging system, and we recommend its use in future clinical studies to stratify patients with NDMM effectively with respect to the relative risk to their survival. PMID:26240224

Space hands-on universe telescope and orbiting wide-angle light-collector telescope to be built on the Japanese experiment module exposure facility of the international space station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takahashi, Y.; Ebisuzaki, T.; Pennypacker, C.

1999-01-01

A concept study to build great observatories on, and deploy from, the ISS is presented. Use of the ISS infra-structure including robotic arms and astronauts{close_quote} EVA would permit a construction of very large optical telescopes. We envisage that the second phase of the ISS after its initial construction can landmark a new era for both ISS and Space Sciences. Ultimately, this study would plan a 10-or 20-meter class space telescope. For its first step, we envisioned an immediate extension of the Exposed Facility of ISS for building a {open_quotes}Work-bench{close_quotes} for this purpose. Initial activities can begin with two modest-sized telescopesmore » soon after the ISS construction. These early missions being studied are space Hands-On Universe Telescope (SHOUT) and Orbiting Wide-angle Light-collector (OWL). SHOUT is a 1-m telescope for science education. It will be built and adjusted on the exposure module of the Japanese Experiment Module (JEM) of the International Space Station by using a robotic arm and the EVA of astronauts. We also seek the possibility to release it from ISS after its perfection on orbit, so that it is free from the vibrations and gas contaminations on and around the ISS. SHOUT is an engineering prototype of 10-m Space Telescope (Space SUBARU Telescope). It would be scaled from the Space-SUBARU telescope so that the testing with the SHOUT would warrant the required specifications for the 10-meter Space-SUBARU construction on the ISS. The goal of the test with the SHOUT is to warrant a spatial resolution of 0.01 arc-seconds using the active/adaptive optics. It will test the following three major engineering challenges: (1) active/adaptive optics in space; (2) building of large structures by astronauts; and (3) release of a spacecraft from ISS to a free-flying orbit. The present feasibility study for the next generation great observatories that are to be built on the JEM Exposure Facility (EF) has been already funded by the Japan Space Forum, under the auspices of the National Space Development Agency (NASDA) of Japan. Included in this study are SHOUT, Space SUBARU telescope as well as OWL, Large Area gamma-ray Telescope (LAGT), and Space Submilimeter and Infrared Telescope (S-SIT). {copyright} {ital 1999 American Institute of Physics.}« less

The Challenges and Opportunities of a Commercial Astronaut Mission to the ISS

NASA Astrophysics Data System (ADS)

Mirra, C.; Carl, S.

2002-01-01

ISS flight opportunities for ESA astronauts are considered as a vital source to meet the objectives (utilisation, operation and political), which Europe has established in participating to the International Space Station programme. Recent internal ESA assessments have demonstrated that, in order to satisfy the objectives drawn in the ESA ISS Exploitation programme, a rate of three flights per year for European Astronauts should be maintained as minimum objective. Since the establishment of a single European Astronaut Corps and having regard of the ISS flight opportunities provided through national space agencies, the current European astronauts flight rate is rather lower than the above three flights per year. In order to improve this situation, in the context of the activation of the ESA ISS Commercialisation programme, the Agency contracted Intospace to develop the conditions for the establishment of ESA astronaut missions with the financial support of both ESA and the private sector or, in future, the latter only. The study led to the definition of a "commercial astronaut", as a member of the European Astronaut Corp that will be assigned the responsibility to perform research and commercial space projects in a given ISS mission scenario. This paper will present the recent outcomes of a detailed study phase, including highlights on possible implementation of a private sector-supported astronaut mission to the ISS.

Lessons Learned for Cx PRACA. Constellation Program Problem Reporting, Analysis and Corrective Action Process and System

NASA Technical Reports Server (NTRS)

Kelle, Pido I.; Ratterman, Christian; Gibbs, Cecil

2009-01-01

This slide presentation reviews the Constellation Program Problem Reporting, Analysis and Corrective Action Process and System (Cx PRACA). The goal of the Cx PRACA is to incorporate Lessons learned from the Shuttle, ISS, and Orbiter programs by creating a single tool for managing the PRACA process, that clearly defines the scope of PRACA applicability and what must be reported, and defines the ownership and responsibility for managing the PRACA process including disposition approval authority. CxP PRACA is a process, supported by a single information gathering data module which will be integrated with a single CxP Information System, providing interoperability, import and export capability making the CxP PRACA a more effective and user friendly technical and management tool.

Assessment and Control of Spacecraft Charging Risks on the International Space Station

NASA Technical Reports Server (NTRS)

Koontz, Steve; Edeen, Marybeth; Spetch, William; Dalton, Penni; Keening, Thomas

2003-01-01

Electrical interactions between the F2 region ionospheric plasma and the 160V photovoltaic (PV) electrical power system on the International Space Station (ISS) can produce floating potentials (FP) on the ISS conducting structure of greater magnitude than are usually observed on spacecraft in low-Earth orbit. Flight through the geomagnetic field also causes magnetic induction charging of ISS conducting structure. Charging processes resulting from interaction of ISS with auroral electrons may also contribute to charging albeit rarely. The magnitude and frequency of occurrence of possibly hazardous charging events depends on the ISS assembly stage (six more 160V PV arrays will be added to ISS), ISS flight configuration, ISS position (latitude and longitude), and the natural variability in the ionospheric flight environment. At present, ISS is equipped with two plasma contactors designed to control ISS FP to within 40 volts of the ambient F2 plasma. The negative-polarity grounding scheme utilized in the ISS 160V power system leads, naturally, to negative values of ISS FP. A negative ISS structural FP leads to application of electrostatic fields across the dielectrics that separate conducting structure from the ambient F2 plasma, thereby enabling dielectric breakdown and arcing. Degradation of some thermal control coatings and noise in electrical systems can result. Continued review and evaluation of the putative charging hazards, as required by the ISS Program Office, revealed that ISS charging could produce a risk of electric shock to the ISS crew during extra vehicular activity. ISS charging risks are being evaluated in ongoing ISS charging measurements and analysis campaigns. The results of ISS charging measurements are combined with a recently developed detailed model of the ISS charging process and an extensive analysis of historical ionospheric variability data, to assess ISS charging risks using Probabilistic Risk Assessment (PRA) methods. The PRA analysis (estimated frequency of occurrence and severity of the charging hazards) are then used to select the hazard control strategy that provides the best overall safety and mission success environment for ISS and the ISS crew. This paper presents: 1) a summary of ISS spacecraft charging analysis, measurements, observations made to date, 2) plans for future ISS spacecraft charging measurement campaigns, and 3) a detailed discussion of the PRA strategy used to assess ISS spacecraft charging risks and select charging hazard control strategies

Assessment and Control of International Space Station Spacecraft Charging Risks

NASA Astrophysics Data System (ADS)

Koontz, S.; Edeen, M.; Spetch, W.; Dalton, P.; Keeping, T.; Minow, J.

2003-12-01

Electrical interactions between the F2 region ionospheric plasma and the 160V photovoltaic (PV) electrical power system on the International Space Station (ISS) can produce floating potentials (FP) on ISS conducting structure of greater magnitude than are usually observed on spacecraft in low-Earth orbit. Flight through the geomagnetic field also causes magnetic induction charging of ISS conducting structure. Charging processes resulting from interaction of ISS with auroral electrons may also contribute to charging, albeit rarely. The magnitude and frequency of occurrence of possibly hazardous charging events depends on the ISS assembly stage (six more 160V PV arrays will be added to ISS), ISS flight configuration, ISS position (latitude and longitude), and the natural variability in the ionospheric flight environment. At present, ISS is equipped with two plasma contactors designed to control ISS FP to within 40 volts of the ambient F2 plasma. The negative-polarity grounding scheme utilized in the ISS 160V power system leads, naturally, to negative values of ISS FP. A negative ISS structural FP leads to application of electrostatic fields across the dielectrics that separate conducting structure from the ambient F2 plasma, thereby enabling dielectric breakdown and arcing. Degradation of some thermal control coatings and noise in electrical systems can result. Continued review and evaluation of the putative charging hazards, as required by the ISS Program Office, revealed that ISS charging could produce a risk of electric shock to the ISS crew during extra vehicular activity. ISS charging risks are being evaluated in ongoing ISS charging measurements and analysis campaigns. The results of ISS charging measurements are combined with a recently developed detailed model of the ISS charging process and an extensive analysis of historical ionospheric variability data, to assess ISS charging risks using Probabilistic Risk Assessment (PRA) methods. The PRA analysis (estimated frequency of occurrence and severity of the charging hazards) are then used to select the hazard control strategy that provides the best overall safety and mission success environment for ISS and the ISS crew. This paper presents: 1) a summary of ISS spacecraft charging analysis, measurements, observations made to date, 2) plans for future ISS spacecraft charging measurement campaigns, and 3) a detailed discussion of the PRA strategy used to assess ISS spacecraft charging risks and select charging hazard control strategies.

School-Wide Discipline Policies: In-School Suspension in One Middle School.

ERIC Educational Resources Information Center

Chung, Gloria; Paul, Rachel

One of the more perplexing problems facing middle schools is the use of in-school suspension (ISS). So as to understand better the effects of this practice, one middle school's ISS program was studied and evaluated. Current research on ISS polices and practices is limited, and there is little evidence that supports its use or reform; however, in…

Cricothyroidotomy In Situ Simulation Curriculum (CRIC Study): Training Residents for Rare Procedures.

PubMed

Petrosoniak, Andrew; Ryzynski, Agnes; Lebovic, Gerald; Woolfrey, Karen

2017-04-01

Technical skill acquisition for rare procedures can be challenging given the few real-life training opportunities. In situ simulation (ISS), a training technique that takes place in the actual workplace, is a promising method to promote environmental fidelity for rare procedures. This study evaluated a simulation-based technical skill curriculum for cricothyroidotomy using deliberate practice, followed by an ISS evaluation session. Twenty emergency medicine residents participated in a two-part curriculum to improve cricothryoidotomy performance. A pretest established participant baseline technical skill. The training session consisted of two parts, didactic teaching followed by deliberate practice using a task-training manikin. A posttest consisted of an unannounced, high-fidelity ISS, during an emergency department shift. The primary outcome was the mean performance time between the pretest and posttest sessions. Skill performance was also evaluated using a checklist scale and global rating scale. Cricothyroidotomy performance time improved significantly from pretest to posttest sessions (mean difference, 59 seconds; P < 0.0001). Both checklist and global rating scales improved significantly from the pretest to the posttest with a mean difference of 1.82 (P = 0.002) and 6.87 (P = 0.0025), respectively. Postcourse survey responses were favorable for both the overall curriculum experience and the unannounced ISS. This pilot study demonstrated that unannounced ISS is feasible and can be used to effectively measure cricothyroidotomy performance among EM residents. After a two-part training session consisting of didactic learning and deliberate practice, improved cricothyroidotomy skill performance was observed during an unannounced ISS in the emergency department. The integration of ISS in cricothyroidotomy training represents a promising approach; however, further study is needed to establish its role.

ISS and Space Environment Interactions in Event of Plasma Contactor Failure

NASA Technical Reports Server (NTRS)

Carruth, M. R., Jr.; Munafo, Paul M. (Technical Monitor)

2000-01-01

The International Space Station (ISS), illustrated in Figure 1, will be the largest, highest power spacecraft placed in orbit. Because of this the design of the electrical power system diverged markedly from previous systems. The solar arrays will operate at 160 V and the power distribution voltage will be 120 V. The structure is grounded to the negative side of the solar arrays so under the right circumstances it is possible to drive the ISS potential very negative. A plasma contactor has been added to the ISS to provide control of the ISS structure potential relative to the ambient plasma. The ISS requirement is that the ISS structure not be greater than 40 V positive or negative of local plasma. What are the ramifications of operating large structures with such high voltage power systems? The application of a plasma contactor on ISS controls the potential between the structure and the local plasma, preventing degrading effects. It is conceivable that there can be situations where the plasma contactor might be non-functional. This might be due to lack of power, the need to turn it off during some of the build-up sequences, the loss of functionality for both plasma contactors before a replacement can be installed, and similar circumstances. A study was undertaken to understand how important it is to have the contactor functioning and how long it might be off before unacceptable degradation to ISS could occur.

International Space Station (ISS) External Thermal Control System (ETCS) Loop A Pump Module (PM) Jettison Options Assessment

NASA Technical Reports Server (NTRS)

Murri, Daniel G.; Dwyer Cianciolo, Alicia; Shidner, Jeremy D.; Powell, Richard W.

2014-01-01

On December 11, 2013, the International Space Station (ISS) experienced a failure of the External Thermal Control System (ETCS) Loop A Pump Module (PM). To minimize the number of extravehicular activities (EVA) required to replace the PM, jettisoning the faulty pump was evaluated. The objective of this study was to independently evaluate the jettison options considered by the ISS Trajectory Operations Officer (TOPO) and to provide recommendations for safe jettison of the ETCS Loop A PM. The simulation selected to evaluate the TOPO options was the NASA Engineering and Safety Center's (NESC) version of Program to Optimize Simulated Trajectories II (POST2) developed to support another NESC assessment. The objective of the jettison analysis was twofold: (1) to independently verify TOPO posigrade and retrograde jettison results, and (2) to determine jettison guidelines based on additional sensitivity, trade study, and Monte Carlo (MC) analysis that would prevent PM recontact. Recontact in this study designates a propagated PM trajectory that comes within 500 m of the ISS propagated trajectory. An additional simulation using Systems Tool Kit (STK) was run for independent verification of the POST2 simulation results. Ultimately, the ISS Program removed the PM jettison option from consideration. However, prior to the Program decision, the retrograde jettison option remained part of the EVA contingency plan. The jettison analysis presented showed that, in addition to separation velocity/direction and the atmosphere conditions, the key variables in determining the time to recontact the ISS is highly dependent on the ballistic number (BN) difference between the object being jettisoned and the ISS.

Preliminary Findings from the SHERE ISS Experiment

NASA Technical Reports Server (NTRS)

Hall, Nancy R.; McKinley, Gareth H.; Erni, Philipp; Soulages, Johannes; Magee, Kevin S.

2009-01-01

The Shear History Extensional Rheology Experiment (SHERE) is an International Space Station (ISS) glovebox experiment designed to study the effect of preshear on the transient evolution of the microstructure and viscoelastic tensile stresses for monodisperse dilute polymer solutions. The SHERE experiment hardware was launched on Shuttle Mission STS-120 (ISS Flight 10A) on October 22, 2007, and 20 fluid samples were launched on Shuttle Mission STS-123 (ISS Flight 10/A) on March 11, 2008. Astronaut Gregory Chamitoff performed experiments during Increment 17 on the ISS between June and September 2008. A summary of the ten year history of the hardware development, the experiment's science objectives, and Increment 17's flight operations are discussed in the paper. A brief summary of the preliminary science results is also discussed.

MISSE-X: An ISS External Platform for Space Environmental Studies in the Post-Shuttle Era

NASA Technical Reports Server (NTRS)

Thibeault, Sheila A.; Cooke, Stuart A.; Ashe, Melissa P.; Saucillo, Rudolph J.; Murphy, Douglas G.; deGroh, Kim K.; Jaworske, Donald A.; Nguyen, Quang-Viet

2011-01-01

Materials International Space Station Experiment-X (MISSE-X) is a proposed International Space Station (ISS) external platform for space environmental studies designed to advance the technology readiness of materials and devices critical for future space exploration. The MISSE-X platform will expand ISS utilization by providing experimenters with unprecedented low-cost space access and return on investment (ROI). As a follow-on to the highly successful MISSE series of ISS experiments, MISSE-X will provide advances over the original MISSE configurations including incorporation of plug-and-play experiments that will minimize return mass requirements in the post-Shuttle era, improved active sensing and monitoring of the ISS external environment for better characterization of environmental effects, and expansion of the MISSE-X user community through incorporation of new, customer-desired capabilities. MISSE-X will also foster interest in science, technology, engineering, and math (STEM) in primary and secondary schools through student collaboration and participation.1,2

Food System Trade Study for a Near-Term Mars Mission

NASA Technical Reports Server (NTRS)

Levri, Julie; Luna, Bernadette (Technical Monitor)

2000-01-01

This paper evaluates several food system options for a near-term Mars mission, based on plans for the 120-day BIO-Plex test. Food systems considered in the study are based on the International Space Station (ISS) Assembly Phase and Assembly Complete food systems. The four systems considered are: 1) ISS assembly phase food system (US portion) with individual packaging without salad production; 2) ISS assembly phase food system (US portion) with individual packaging, with salad production; 3) ISS assembly phase food system (US portion) with bulk packaging, with salad production; 4) ISS assembly complete food system (US portion) with bulk packaging with salad and refrigeration/freezing. The food system options are assessed using equivalent system mass (ESM), which evaluates each option based upon the mass, volume, power, cooling and crewtime requirements that are associated with each food system option. However, since ESM is unable to elucidate the differences in psychological benefits between the food systems, a qualitative evaluation of each option is also presented.

Mitigation of EMU Cut Glove Hazard from Micrometeoroid and Orbital Debris Impacts on ISS Handrails

NASA Technical Reports Server (NTRS)

Ryan, Shannon; Christiansen, Eric L.; Davis, Bruce A.; Ordonez, Erick

2009-01-01

Recent cut damages sustained on crewmember gloves during extravehicular activity (ISS) onboard the International Space Station (ISS) have been caused by contact with sharp edges or a pinch point according to analysis of the damages. One potential source are protruding sharp edged crater lips from micrometeoroid and orbital debris (MMOD) impacts on metallic handrails along EVA translation paths. A number of hypervelocity impact tests were performed on ISS handrails, and found that mm-sized projectiles were capable of inducing crater lip heights two orders of magnitude above the minimum value for glove abrasion concerns. Two techniques were evaluated for mitigating the cut glove hazard of MMOD impacts on ISS handrails: flexible overwraps which act to limit contact between crewmember gloves and impact sites, and; alternate materials which form less hazardous impact crater profiles. In parallel with redesign efforts to increase the cut resilience of EMU gloves, the modifications to ISS handrails evaluated in this study provide the means to significantly reduce cut glove risk from MMOD impact craters

Burden of disease of reoperations in instrumental spinal surgeries in Germany.

PubMed

Jacob, Christian; Annoni, Elena; Haas, Jennifer Scarlet; Braun, Sebastian; Winking, Michael; Franke, Jörg

2016-03-01

To estimate the incidence of instrumental spinal surgeries (ISS) and consecutive reoperations and to calculate the related resource utilization and costs. ISS and subsequent reoperations were identified retrospectively using surgery codes in claims data. The study period included January 01, 2009 to December 31, 2011. The reoperation rate was calculated for 1 year after the primary ISS. Resource utilization and costs were analyzed by group comparison. A total of 3316 incident ISS patients were identified in 2010 with an annual reoperation rate of 9.98% (95% CI 8.98-11.02%). Mean costs per patient were €11,331 per ISS and €11,370 per reoperation, with €8432 directly attributed to the reoperation and €2938 to additional resources. Costs of ISS and subsequent reoperations have a significant impact on health insurances budgets. The annual cost of reoperations exceeds the direct cost of the primary surgery driven by the need for further inpatient and outpatient care.

In-stent stenosis after stent-assisted coiling: incidence, predictors and clinical outcomes of 435 cases.

PubMed

Chalouhi, Nohra; Drueding, Ross; Starke, Robert M; Jabbour, Pascal; Dumont, Aaron S; Gonzalez, L Fernando; Rosenwasser, Robert; Tjoumakaris, Stavropoula

2013-03-01

Neuroform and Enterprise are widely used self-expanding stents designed to treat wide-necked intracranial aneurysms. To assess the incidence, clinical significance, predictors, and outcomes of in-stent stenosis (ISS). Angiographic studies and hospital records were retrospectively reviewed for 435 patients treated between 2005 and 2011 in our institution. A multivariable regression analysis was conducted to determine the predictors of ISS. The Neuroform stent was used in 264 patients (60.7%) and the Enterprise in 171 patients (39.3%). A total of 11 patients (2.5%) demonstrated some degree of ISS during the follow-up period at a mean time point of 4.2 months (range, 2-12 months). The stenosis was mild (< 50%) in 8 patients (1.8%), moderate (50-75%) in 2 patients (0.5%), and severe (> 75%) in 1 patient (0.2%). No patients were symptomatic or required further intervention. There was complete ISS resolution in 2 patients, partial resolution in 2 patients, and no change in 5 patients on follow-up angiography. Patients developing ISS were significantly younger than those without ISS (40.3 vs. 54.9 years; P < .001). ISS rates were 2.7% with the Neuroform and 2.3% with the Enterprise stent (P = .6). In multivariable analysis, younger patient age (odds ratio = 0.92; P = .008), carotid ophthalmic aneurysm location (odds ratio = 7.7; P =0.01), and carotid terminus aneurysm location (odds ratio = 8.1; P = .009) were strong independent predictors of ISS. The type of stent was not a predictive factor. Neuroform and Enterprise ISS is an uncommon, often transient, and clinically benign complication. Younger patients and those harboring anterior circulation aneurysms located at ophthalmic and carotid terminus locations are more likely to develop ISS.

Comprehensive evaluation of the revised international staging system in multiple myeloma patients treated with novel agents as a primary therapy.

PubMed

Cho, Hyungwoo; Yoon, Dok Hyun; Lee, Jung Bok; Kim, Sung-Yong; Moon, Joon Ho; Do, Young Rok; Lee, Jae Hoon; Park, Yong; Lee, Ho Sup; Eom, Hyeon Seok; Shin, Ho-Jin; Min, Chang-Ki; Kim, Jin Seok; Jo, Jae-Cheol; Kang, Hye Jin; Mun, Yeung-Chul; Lee, Won Sik; Lee, Je-Jung; Suh, Cheolwon; Kim, Kihyun

2017-12-01

The revised International Staging System (R-ISS) has recently been developed to improve the risk stratification of multiple myeloma (MM) patients over the ISS. We assessed the R-ISS in MM patients who were treated with novel agents as a primary therapy and evaluated its discriminative power and ability to reclassify patients from the ISS. A total of 514 newly diagnosed MM patients treated with novel agents including thalidomide, bortezomib, and lenalidomide as a primary therapy were included in this retrospective analysis. With a median follow-up duration of 42.3 months (range, 40.5-44.1), the median overall survival (OS) was 61.0 months. There was a significant difference in median OS (not reached, 60.9, and 50.1 months for stages 1, 2, and 3, respectively, P < 0.001) among the three stages of R-ISS. The C-statistic was significantly greater for R-ISS than for ISS (0.769 vs. 0.696, P < 0.001). The event NRI was -0.08 (95% confidence interval [CI], -0.18-0.01) and the non-event NRI was 0.05 (95% CI, -0.03-0.10), resulting in a total NRI of -0.03 (95% CI, -0.14-0.08, P = 0.602). The R-ISS performs well and has significantly better discriminative power than the ISS in MM patients treated with novel agents as a primary therapy. However, it does not better reclassify patients from the ISS, suggesting that there is still room to improve the staging system. Moreover, new statistical measures for assessing and quantifying the risk prediction of new prognostic models are necessary in future studies. © 2017 Wiley Periodicals, Inc.

Modeling Ionosphere Environments: Creating an ISS Electron Density Tool

NASA Technical Reports Server (NTRS)

Gurgew, Danielle N.; Minow, Joseph I.

2011-01-01

The International Space Station (ISS) maintains an altitude typically between 300 km and 400 km in low Earth orbit (LEO) which itself is situated in the Earth's ionosphere. The ionosphere is a region of partially ionized gas (plasma) formed by the photoionization of neutral atoms and molecules in the upper atmosphere of Earth. It is important to understand what electron density the spacecraft is/will be operating in because the ionized gas along the ISS orbit interacts with the electrical power system resulting in charging of the vehicle. One instrument that is already operational onboard the ISS with a goal of monitoring electron density, electron temperature, and ISS floating potential is the Floating Potential Measurement Unit (FPMU). Although this tool is a valuable addition to the ISS, there are limitations concerning the data collection periods. The FPMU uses the Ku band communication frequency to transmit data from orbit. Use of this band for FPMU data runs is often terminated due to necessary observation of higher priority Extravehicular Activities (EVAs) and other operations on ISS. Thus, large gaps are present in FPMU data. The purpose of this study is to solve the issue of missing environmental data by implementing a secondary electron density data source, derived from the COSMIC satellite constellation, to create a model of ISS orbital environments. Extrapolating data specific to ISS orbital altitudes, we model the ionospheric electron density along the ISS orbit track to supply a set of data when the FPMU is unavailable. This computer model also provides an additional new source of electron density data that is used to confirm FPMU is operating correctly and supplements the original environmental data taken by FPMU.

The Value of Injury Severity Score and Abbreviated Injury Scale in the Management of Traumatic Injuries of Parenchymal Abdominal Organs.

PubMed

Grandić, Leo; Olić, Ivna; Pogorelić, Zenon; Mrklić, Ivana; Perko, Zdravko

2017-09-01

The aim of this study was to investigate the influence of etiology, types of injury, levels of consciousness and the Injury Severity Score (ISS) and Abbreviated Injury Scale (AIS) values on the selection of treatment modality and survival in patients with injuries of parenchymal abdominal organs. Case records of 224 patients treated for traumatic injury of parenchymal abdominal organs from January 2003 until December 2015 were reviewed. Th e values of ISS and AIS of injury severity were calculated and compared to the values obtained according to the etiology, state of consciousness and survival. Of the 224 patients, 172 (76.8%) were treated by surgical approach and 52 (23.2%) were treated conservatively. Th e mean patient age was 40.1}18.3 years. Th ere were 97 (43.3%) polytrauma cases. Of the 224 injured patients, 143 (63.8%) were treated with transfusions of blood products. Two hundred and six (92%) patients survived. Th e mean AIS and ISS values were significantly lower in patients that survived (AIS=3; ISS=28) than in those that died (AIS=5; ISS=34) (p< 0.001). There was a statistically significant difference in AIS and ISS values between conscious (AIS=2.7; ISS=25.9) and unconscious (AIS=3.2; ISS=33) patients (p< 0.001). Of the 224 patients that did not survive, 18 (8%) were hemodynamically unstable. Survival depended on hemodynamic stability at admission; the ISS and AIS values were associated with the injuries and state of consciousness at admission. Hemodynamic stability, state of consciousness, and ISS and AIS values were the quality predictors of survival after abdominal traumatic injury.

Close-up view Pea pods in Russian Lada greenhouse

NASA Image and Video Library

2003-05-12

ISS007-E-05295 (May 2003) --- Inside the Russian Lada greenhouse, these peas have dried and “gone to seed.” They are part of an experiment to investigate plant development and genetics. The crew of the International Space Station (ISS) will soon harvest the seeds. Eventually, some will be re-planted onboard the ISS and some will be returned to Earth for further study.

iss047e066248

NASA Image and Video Library

2016-04-19

ISS047e066248 (04/19/2016) --- NASA astronaut and Expedition 47 Flight Engineer Jeff Williams works with the Wet Lab RNA SmartCycler on-board the International Space Station. Wetlab RNA SmartCycler is a research platform for conducting real-time quantitative gene expression analysis aboard the ISS. The system enables spaceflight genomic studies involving a wide variety of biospecimen types in the unique microgravity environment of space.

Utilizing ISS Camera Systems for Scientific Analysis of Lightning Characteristics and comparison with ISS-LIS and GLM

NASA Astrophysics Data System (ADS)

Schultz, C. J.; Lang, T. J.; Leake, S.; Runco, M.; Blakeslee, R. J.

2017-12-01

Video and still frame images from cameras aboard the International Space Station (ISS) are used to inspire, educate, and provide a unique vantage point from low-Earth orbit that is second to none; however, these cameras have overlooked capabilities for contributing to scientific analysis of the Earth and near-space environment. The goal of this project is to study how georeferenced video/images from available ISS camera systems can be useful for scientific analysis, using lightning properties as a demonstration. Camera images from the crew cameras and high definition video from the Chiba University Meteor Camera were combined with lightning data from the National Lightning Detection Network (NLDN), ISS-Lightning Imaging Sensor (ISS-LIS), the Geostationary Lightning Mapper (GLM) and lightning mapping arrays. These cameras provide significant spatial resolution advantages ( 10 times or better) over ISS-LIS and GLM, but with lower temporal resolution. Therefore, they can serve as a complementarity analysis tool for studying lightning and thunderstorm processes from space. Lightning sensor data, Visible Infrared Imaging Radiometer Suite (VIIRS) derived city light maps, and other geographic databases were combined with the ISS attitude and position data to reverse geolocate each image or frame. An open-source Python toolkit has been developed to assist with this effort. Next, the locations and sizes of all flashes in each frame or image were computed and compared with flash characteristics from all available lightning datasets. This allowed for characterization of cloud features that are below the 4-km and 8-km resolution of ISS-LIS and GLM which may reduce the light that reaches the ISS-LIS or GLM sensor. In the case of video, consecutive frames were overlaid to determine the rate of change of the light escaping cloud top. Characterization of the rate of change in geometry, more generally the radius, of light escaping cloud top was integrated with the NLDN, ISS-LIS and GLM to understand how the peak rate of change and the peak area of each flash aligned with each lightning system in time. Flash features like leaders could be inferred from the video frames as well. Testing is being done to see if leader speeds may be accurately calculated under certain circumstances.

[Predictive quality of the injury severity score in the systematic use of cranial MRI].

PubMed

Woischneck, D; Lerch, K; Kapapa, T; Skalej, M; Firsching, R

2010-09-01

The ABBREVIATED INJURY SCORE (AIS) for the head is mostly coded on the basis of cranial computed tomography (CT). It defines, to a large extent, the predictive potency of the INJURY SEVERITY SCORE (ISS). The present study investigates whether the predictive capacity of the ISS can be improved by the systematic use of data from cranial MRI. 167 patients, who had been in a coma for at least 24 hours following trauma, underwent an MRI examination within 8 days. All had been found to have an intracranial injury on initial CT. 49 % had also suffered extracranial injuries. The GLASGOW OUTCOME SCALE (GOS) was determined 6 months post trauma. AIS, ISS and GOS values were rated as ordinal measurements. A contingency table was used as the statistical method of analysis, with a significance assumed as p < 0.05 (Chi (2) test). The median ISS based on CT was 16 and did not correlate with the GOS. 63 % of the patients revealed brain stem lesions on MRI. If these were coded with an AIS of 5, the median ISS increased significantly to 29. Thus, the correlation to the GOS was now significant. At ISS scores of 5-9, 18 % of the patients died; at scores of 50-54 the rate of favourable treatment outcomes still amounted to 50 %. Since it is now known that brain stem lesions can also have a favourable prognosis, the AIS coding was modified and adapted to the mortality of the singular types of lesion. Hence the median ISS again decreased to 16. The correlation to the GOS was significant, and the predictive potency of the ISS further improved. The prognostic potency of the REVISED INJURY SEVERITY CLASSIFICATION (RISC) score was improved by use of adapted MRI data. If visible brain stem lesions on MRI were coded according to the AIS guidelines, there was a significant increase in the ISS which correlated significantly to the GOS. If the AIS coding was adjusted to the prognostic significance of individual brain stem lesions, there was a further improvement in the prognostic potency of the ISS. The study encourages the inclusion of data obtained from MRI diagnostics in the ISS calculation. There are alternative ways. © Georg Thieme Verlag KG Stuttgart · New York.

Comparison of antibiotic resistance, biofilm formation and conjugative transfer of Staphylococcus and Enterococcus isolates from International Space Station and Antarctic Research Station Concordia.

PubMed

Schiwon, Katarzyna; Arends, Karsten; Rogowski, Katja Marie; Fürch, Svea; Prescha, Katrin; Sakinc, Türkan; Van Houdt, Rob; Werner, Guido; Grohmann, Elisabeth

2013-04-01

The International Space Station (ISS) and the Antarctic Research Station Concordia are confined and isolated habitats in extreme and hostile environments. The human and habitat microflora can alter due to the special environmental conditions resulting in microbial contamination and health risk for the crew. In this study, 29 isolates from the ISS and 55 from the Antarctic Research Station Concordia belonging to the genera Staphylococcus and Enterococcus were investigated. Resistance to one or more antibiotics was detected in 75.8 % of the ISS and in 43.6 % of the Concordia strains. The corresponding resistance genes were identified by polymerase chain reaction in 86 % of the resistant ISS strains and in 18.2 % of the resistant Concordia strains. Plasmids are present in 86.2 % of the ISS and in 78.2 % of the Concordia strains. Eight Enterococcus faecalis strains (ISS) harbor plasmids of about 130 kb. Relaxase and/or transfer genes encoded on plasmids from gram-positive bacteria like pIP501, pRE25, pSK41, pGO1 and pT181 were detected in 86.2 % of the ISS and in 52.7 % of the Concordia strains. Most pSK41-homologous transfer genes were detected in ISS isolates belonging to coagulase-negative staphylococci. We demonstrated through mating experiments that Staphylococcus haemolyticus F2 (ISS) and the Concordia strain Staphylococcus hominis subsp. hominis G2 can transfer resistance genes to E. faecalis and Staphylococcus aureus, respectively. Biofilm formation was observed in 83 % of the ISS and in 92.7 % of the Concordia strains. In conclusion, the ISS isolates were shown to encode more resistance genes and possess a higher gene transfer capacity due to the presence of three vir signature genes, virB1, virB4 and virD4 than the Concordia isolates.

CRISIS UNDER THE RADAR: ILLICIT AMPHETAMINE USE IS REACHING EPIDEMIC PROPORTIONS AND CONTRIBUTING TO RESOURCE OVER-UTILIZATION AT A LEVEL 1 TRAUMA CENTER.

PubMed

Gemma, Vincent A; Chapple, Kristina A; Goslar, Pamela W; Israr, Sharjeel; Petersen, Scott R; Weinberg, Jordan A

2018-05-21

Trauma centers reported illicit amphetamine use in approximately 10% of trauma admissions in the previous decade. From experience at a trauma center located in a southwestern metropolis, our perception is that illicit amphetamine use is on the rise, and that these patients utilize in-hospital resources beyond what would be expected for their injuries. The purpose of this study was to document the incidence of illicit amphetamine use among our trauma patients and to evaluate its impact on resource utilization. We conducted a retrospective cohort study using 7 consecutive years of data (starting July 2010) from our institution's trauma registry. Toxicology screenings were used to categorize patients into one of three groups: illicit amphetamine, other drugs, or drug free. Adjusted linear and logistic regression models were used to predict hospital cost, length of stay, ICU admission and ventilation between drug groups. Models were conducted with combined injury severity (ISS) and then repeated for ISS <9, ISS 9-15 and ISS 16 and above. 8,589 patients were categorized into the following three toxicology groups: 1255 (14.6%) illicit amphetamine, 2214 (25.8%) other drugs, and 5120 (59.6%) drug free. Illicit amphetamine use increased threefold over the course of the study (from 7.85% to 25.0% of annual trauma admissions). Adjusted linear models demonstrated that illicit amphetamine among patients with ISS<9 was associated with 4.6% increase in hospital cost (P=.019) and 7.4% increase in LOS (P=.043). Logistic models revealed significantly increased odds of ventilation across all ISS groups and increased odds of ICU admission when all ISS groups were combined (P=.001) and within the ISS<9 group (P=.002). Hospital resource utilization of amphetamine patients with minor injuries is significant. Trauma centers with similar epidemic growth in proportion of amphetamine patients face a potentially significant resource strain relative to other centers. Prognostic and Epidemiological LEVEL OF EVIDENCE: III.

Design and Performance Evaluation of a UWB Communication and Tracking System for Mini-AERCam

NASA Technical Reports Server (NTRS)

Barton, Richard J.

2005-01-01

NASA Johnson Space Center (JSC) is developing a low-volume, low-mass, robotic free-flying camera known as Mini-AERCam (Autonomous Extra-vehicular Robotic Camera) to assist the International Space Station (ISS) operations. Mini-AERCam is designed to provide astronauts and ground control real-time video for camera views of ISS. The system will assist ISS crewmembers and ground personnel to monitor ongoing operations and perform visual inspections of exterior ISS components without requiring extravehicular activity (EAV). Mini-AERCam consists of a great number of subsystems. Many institutions and companies have been involved in the R&D for this project. A Mini-AERCam ground control system has been studied at Texas A&M University [3]. The path planning and control algorithms that direct the motions of Mini-AERCam have been developed through the joint effort of Carnegie Mellon University and the Texas Robotics and Automation Center [5]. NASA JSC has designed a layered control architecture that integrates all functions of Mini-AERCam [8]. The research described in this report is part of a larger effort focused on the communication and tracking subsystem that is designed to perform three major tasks: 1. To transmit commands from ISS to Mini-AERCam for control of robotic camera motions (downlink); 2. To transmit real-time video from Mini-AERCam to ISS for inspections (uplink); 3. To track the position of Mini-AERCam for precise motion control. The ISS propagation environment is unique due to the nature of the ISS structure and multiple RF interference sources [9]. The ISS is composed of various truss segments, solar panels, thermal radiator panels, and modules for laboratories and crew accommodations. A tracking system supplemental to GPS is desirable both to improve accuracy and to eliminate the structural blockage due to the close proximity of the ISS which could at times limit the number of GPS satellites accessible to the Mini-AERCam. Ideally, the tracking system will be a passive component of the communication system which will need to operate in a time-varying multipath environment created as the robot camera moves over the ISS structure. In addition, due to many interference sources located on the ISS, SSO, LEO satellites and ground-based transmitters, selecting a frequency for the ISS and Mini-AERCam link which will coexist with all interferers poses a major design challenge. To meet all of these challenges, ultrawideband (UWB) radio technology is being studied for use in the Mini-AERCam communication and tracking subsystem. The research described in this report is focused on design and evaluation of passive tracking system algorithms based on UWB radio transmissions from mini-AERCam.

ISS and TPD study of the adsorption and interaction of CO and H2 on polycrystalline Pt

NASA Technical Reports Server (NTRS)

Melendez, Orlando; Hoflund, Gar B.; Schryer, David R.

1990-01-01

The adsorption and interaction of CO and H2 on polycrystalline Pt has been studied using ion scattering spectroscopy (ISS) and temperature programmed desorption (TPD). The ISS results indicate that the initial CO adsorption on Pt takes place very rapidly and saturates the Pt surface with coverage close to a monolayer. ISS also shows that the CO molecules adsorb at an angular orientation from the surface normal and perhaps parallel to the surface. A TPD spectrum obtained after coadsorbing C-12 O-16 and C-13 O-18 on Pt shows no isotopic mixing, which is indicative of molecular CO adsorption. TPD spectra obtained after coadsorbing H2 and CO on polycrystalline Pt provides evidence for the formation of a CO-H surface species.

The International Design Study for the Neutrino Factory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Long, K.

2008-02-21

The International Design Study for a future Neutrino Factory and super-beam facility (the ISS) established the physics case for a high-precision programme of long-baseline neutrino-oscillation measurements. The ISS also identified baseline specifications for the Neutrino Factory accelerator complex and the neutrino detector systems. This paper summarises the objectives of the International Design Study for the Neutrino Factory (the IDS-NF). The IDS-NF will build on the work of the ISS to deliver a Reference Design Report for the Neutrino Factory by 2012/13 and an Interim Design Report by 2010/11.

The International Space Station Supports International Polar Year (IPY)

NASA Technical Reports Server (NTRS)

Evans, Cynthia A.; Pettit, Donald R.

2007-01-01

Every day, ISS astronauts photograph designated sites and dynamic events on the Earth's surface using digital cameras equipped with a variety of lenses. Depending on observation parameters, astronauts can collect high resolution (4-6 m pixel size) or synoptic views (lower resolution but covering very large areas) digital data in 3 (red-green-blue) color bands. ISS crews have daily opportunities to document a variety of high-latitude phenomena. Although lighting conditions, ground track and other viewing parameters change with orbital precessions and season, the 51.6o orbital inclination and 400 km altitude of the ISS provide the crew an unique vantage point for collecting image-based data of polar phenomena, including surface observations to roughly 65o latitude, and upper atmospheric observations that reach nearly to the poles. During the 2007-2009 timeframe of the IPY, polar observations will become a scientific focus for the CEO experiment; the experiment is designated ISS-IPY. We solicit requests from scientists for observations from the ISS that are coordinated with or complement ground-based polar studies. The CEO imagery website for ISS-IPY provides an on-line form that allows IPY investigators to interact with CEO scientists and define their imagery requests. This information is integrated into daily communications with the ISS astronauts about their Earth Observations targets. All data collected are cataloged and posted on the website for downloading and assimilation into IPY projects. Examples of imagery and detailed information about scientific observations from the ISS can also be downloaded from the ISS-IPY web site.

International Space Station: becoming a reality.

PubMed

David, L

1999-07-01

An overview of the development of the International Space Station (ISS) is presented starting with a brief history of space station concepts from the 1960's to the decision to build the present ISS. Other topics discussed include partnerships with Japan, Canada, ESA countries, and Russia; design changes to the ISS modules, the use of the ISS for scientific purposes and the application of space research to medicine on Earth; building ISS modules on Earth, international funding for Russian components, and the political aspects of including Russia in critical building plans. Sidebar articles examine commercialization of the ISS, multinational efforts in the design and building of the ISS, emergency transport to Earth, the use of robotics in ISS assembly, application of lessons learned from the Skylab project to the ISS, initial ISS assembly in May 1999, planned ISS science facilities, and an overview of space stations in science fiction.

Opportunities for Science on the ISS: A Unique Laboratory Environment

NASA Technical Reports Server (NTRS)

Kugler, Justin; Edeen, Marybeth

2010-01-01

This slide presentation reviews the opportunities for scientific discoveries on the International Space Station (ISS). With the crew tended, and availability of long-term studies and the capabilities of the ISS (i.e. microgravity, exposure to the thermosphere and observations at high altitude and velocity) there are many examples of scientific experiments. There are several examples showing that microgravity is different from the effects of gravity.

Concept for a Lunar Transfer Vehicle for Small Satellite Delivery to the Moon from the International Space Station

NASA Technical Reports Server (NTRS)

Elliott, John; Alkalai, Leon

2010-01-01

The International Space Station (ISS) has developed as a very capable center for scientific research in Lower Earth Orbit. An additional potential of the ISS that has not thus far been exploited, is the use of this orbiting plat-form for the assembly and launching of vehicles that could be sent to more distant destinations. This paper reports the results of a recent study that looked at an architecture and conceptual flight system design for a lunar transfer vehicle (LTV) that could be delivered to the ISS in segments, assembled, loaded with payload and launched from the ISS with the objective of delivering multiple small and micro satellites to lunar orbit. The design of the LTV was optimized for low cost and high payload capability, as well as ease of assembly. The resulting design would use solar electric propulsion (SEP) to carry a total payload mass of 250 kg from the ISS to a 100 km lunar orbit. A preliminary concept of operations was developed considering currently available delivery options and ISS capabili-ties that should prove flexible enough to accommodate a variety of payloads and missions. This paper will present an overview of the study, including key trades, mission and flight system design, and notional operational concept.

Problems in the Context Evaluation of Individualized Courses

ERIC Educational Resources Information Center

Plomp, Tjeerd; Van der Meer, Adri

1977-01-01

The development of the Individualized Study System (ISS) in The Netherlands from 1970 to 1975 is reviewed and a case study for first-year engineering is described. A classification of ISS courses illustrates the complexity of the system, with advice offered on the management of individualized study systems. (Author/LBH)

Prognostic scales ISS-RTS-TRISS, PRISM, APACHE II and PTS in decision support of treatment children with severe mechanical trauma.

PubMed

Vasilyeva, I V; Shvirev, S L; Arseniev, S B; Zarubina, T V

2013-01-01

The aim of the present study is to assess a possibility and validity of prognostic scales ISS-RTS-TRISS, PRISM, APACHE II and PTS to be used for the automated calculation in decision support when treating children with severe mechanical traumas. The mentioned scales are used in the Hospital Information System (HIS) MEDIALOG. The retrospective study was conducted using clinical and physiological data collected at the admission and during the first 24 hours of hospitalization in 166 patients. Scales PRISM, APACHE II, ISS-RTS-TRISS were used for calculating the severity of injury and for prognosis in death outcomes. Scale PTS was used for evaluating the severity index only. Our research has shown that ISS-RTS-TRISS has excellent discrimination ability, PRISM and APACHE II prognostic scales have acceptable discrimination ability; moreover, they all have significant calibration ability. PTS scale has acceptable discrimination ability. It has been showed that automated calculation scales ISS-RTS-TRISS, PRISM, APACHE II and PTS are useful for assessing outcomes in children with severe mechanical trauma.

The development of lighting countermeasures for sleep disruption and circadian misalignment during spaceflight.

PubMed

Brainard, George C; Barger, Laura K; Soler, Robert R; Hanifin, John P

2016-11-01

The review addresses the development of a new solid-state lighting system for the International Space Station (ISS) that is intended to enhance the illumination of the working and living environment of astronauts and to improve sleep, circadian entrainment, and daytime alertness. Spaceflight missions often expose astronauts and mission support ground crews to atypical sleep-wake cycles and work schedules. A recent, extensive study describes the sleep characteristics and use of sleep-promoting pharmaceuticals in astronauts before, during, and after spaceflight. The acceptability, feasibility, and efficacy of the new ISS solid-state lighting systems are currently being tested in ground-based, analog studies. Installation of this lighting system on the ISS is scheduled to begin later this year. In-flight testing of this lighting system is planned to take place during ISS spaceflight expeditions. If the new ISS lighting system is capable of improving circadian entrainment and sleep during spaceflight, it should enhance astronaut health, performance, well-being, and safety. Such an advance would open the door to future lighting applications for humans living on Earth.

Foale conducts MSG setup for PFMI experiment in U.S. Lab during Expedition 8

NASA Image and Video Library

2003-11-28

ISS008-E-06301 (28 November 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, installs equipment in the Microgravity Science Glovebox (MSG) for the Pore Formation and Mobility Investigation (PFMI) experiment in the Destiny laboratory on the International Space Station (ISS). This experiment studies how bubbles form in metal and crystal samples, thus deteriorating the samples’ strength and usefulness in experiments.

Foale conducts MSG setup for PFMI experiment in U.S. Lab during Expedition 8

NASA Image and Video Library

2003-11-28

ISS008-E-06309 (28 November 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, installs equipment in the Microgravity Science Glovebox (MSG) for the Pore Formation and Mobility Investigation (PFMI) experiment in the Destiny laboratory on the International Space Station (ISS). This experiment studies how bubbles form in metal and crystal samples, thus deteriorating the samples’ strength and usefulness in experiments.

Foale conducts MSG setup for PFMI experiment in U.S. Lab during Expedition 8

NASA Image and Video Library

2003-11-28

ISS008-E-06300 (28 November 2003) --- Astronaut C. Michael Foale, Expedition 8 mission commander and NASA ISS science officer, installs equipment in the Microgravity Science Glovebox (MSG) for the Pore Formation and Mobility Investigation (PFMI) experiment in the Destiny laboratory on the International Space Station (ISS). This experiment studies how bubbles form in metal and crystal samples, thus deteriorating the samples’ strength and usefulness in experiments.

Space Weather Monitoring for ISS Space Environments Engineering and Crew Auroral Observations

NASA Technical Reports Server (NTRS)

Minow, Joseph; Pettit, Donald R.; Hartman, William A.

2012-01-01

Today s presentation describes how real time space weather data is used by the International Space Station (ISS) space environments team to obtain data on auroral charging of the ISS vehicle and support ISS crew efforts to obtain auroral images from orbit. Topics covered include: Floating Potential Measurement Unit (FPMU), . Auroral charging of ISS, . Real ]time space weather monitoring resources, . Examples of ISS auroral charging captured from space weather events, . ISS crew observations of aurora.

Advanced Cosmic-ray Composition Experiment for Space Station: ISS accommodation study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wefel, John P.

1999-01-22

ACCESS--Advanced Cosmic-ray Composition Experiment for Space Station--was selected as a new Mission Concept under NRA 96-OSS-03, with the goal of combining calorimeter and transition radiation techniques to provide measurements of cosmic rays from Hydrogen through Nickel up to energies approaching the 'knee' in the cosmic ray all particle spectrum, plus providing measurements of the Z>28 (Ultra-Heavy) nuclei at all energies. An instrument to perform such an investigation is undergoing an ISS/STS Accommodation Study at JSC. The instrument concept, the mission plan, and the accommodation issues for an ISS attached payload which include, in part, the carrier, ISS Site, thermal control,more » power, data and operations are described and the current status of these issues, for an ACCESS Mission, is summarized.« less

Validation of the Intrinsic Spirituality Scale (ISS) with Muslims.

PubMed

Hodge, David R; Zidan, Tarek; Husain, Altaf

2015-12-01

This study validates an existing spirituality measure--the intrinsic spirituality scale (ISS)--for use with Muslims in the United States. A confirmatory factor analysis was conducted with a diverse sample of self-identified Muslims (N = 281). Validity and reliability were assessed along with criterion and concurrent validity. The measurement model fit the data well, normed χ2 = 2.50, CFI = 0.99, RMSEA = 0.07, and SRMR = 0.02. All 6 items that comprise the ISS demonstrated satisfactory levels of validity (λ > .70) and reliability (R2 > .50). The Cronbach's alpha obtained with the present sample was .93. Appropriate correlations with theoretically linked constructs demonstrated criterion and concurrent validity. The results suggest the ISS is a valid measure of spirituality in clinical settings with the rapidly growing Muslim population. The ISS may, for instance, provide an efficient screening tool to identify Muslims that are particularly likely to benefit from spiritually accommodative treatments. (c) 2015 APA, all rights reserved).

Spheres: from Ground Development to ISS Operations

NASA Technical Reports Server (NTRS)

Katterhagen, A.

2016-01-01

SPHERES (Synchronized Position Hold Engage and Reorient Experimental Satellites) is an internal International Space Station (ISS) Facility that supports multiple investigations for the development of multi-spacecraft and robotic control algorithms. The SPHERES National Lab Facility aboard ISS is managed and operated by NASA Ames Research Center (ARC) at Moffett Field California. The SPHERES Facility on ISS consists of three self-contained eight-inch diameter free-floating satellites which perform the various flight algorithms and serve as a platform to support the integration of experimental hardware. SPHERES has served to mature the adaptability of control algorithms of future formation flight missions in microgravity (6 DOF (Degrees of Freedom) / long duration microgravity), demonstrate key close-proximity formation flight and rendezvous and docking maneuvers, understand fault diagnosis and recovery, improve the field of human telerobotic operation and control, and lessons learned on ISS have significant impact on ground robotics, mapping, localization, and sensing in three-dimensions - among several other areas of study.

International Polar Year Observations From the International Space Station

NASA Technical Reports Server (NTRS)

Pettit, Donald R.; Runco, Susan; Byrne, Gregory; Willis, Kim; Heydorn, James; Stefanov, William L.; Wilkinson, M. Justin; Trenchard, Michael

2006-01-01

Astronauts aboard the International Space Station (ISS) have several opportunities each day to observe and document high-latitude phenomena. Although lighting conditions, ground track and other viewing parameters change with orbital precessions and season, the 51.6 degree orbital inclination and 400 km altitude of the ISS provide the crew an excellent vantage point for collecting image-based data for IPY investigators. To date, the database of imagery acquired by the Crew Earth Observations (CEO) experiment aboard the ISS (http://eol.jsc.nasa.gov) contains more than 12,000 images of high latitude (above 50 degrees) events such as aurora, mesospheric clouds, sea-ice, high-latitude plankton blooms, volcanic eruptions, and snow cover. The ISS Program will formally participate in IPY through an activity coordinated through CEO entitled Synchronized Observations of Polar Mesospheric Clouds, Aurora and Other Large-scale Polar Phenomena from the ISS and Ground Sites. The activity will augment the existing collection of Earth images taken from the ISS by focusing astronaut observations on polar phenomena. NASA s CEO experiment will solicit requests by IPY investigators for ISS observations that are coordinated with or complement ground-based polar studies. The CEO imagery website (http://eol.jsc.nasa.gov) will provide an on-line form for IPY investigators to interact with CEO scientists and define their imagery requests. This information will be integrated into daily communications with the ISS crews about their Earth Observations targets. All data collected will be cataloged and posted on the website for downloading and assimilation into IPY projects.

Quantitative optical frequency domain imaging assessment of in-stent structures in patients with ST-segment elevation myocardial infarction: impact of imaging sampling rate.

PubMed

Muramatsu, Takashi; García-García, Hector M; Lee, Il Soo; Bruining, Nico; Onuma, Yoshinobu; Serruys, Patrick W

2012-01-01

The impact of the sampling rate (SR) of optical frequency domain imaging (OFDI) on quantitative assessment of in-stent structures (ISS) such as plaque prolapse and thrombus remains unexplored. OFDI after stenting was performed in ST-segment elevation myocardial infarction (STEMI) patients using a TERUMO OFDI system (Terumo Europe, Leuven, Belgium) with 160 frames/s and pullback speed of 20 mm/s. A total of 126 stented segments were analyzed. ISS were classified as either attached or non-attached to stent area boundaries. The volume, mean area and largest area of ISS were assessed according to 4 frequencies of SR, corresponding to distances between the analyzed frames of 0.125, 0.25, 0.50 and 1.0 mm. ISS volume was calculated by integrating cross-sectional ISS areas multiplied by each sampling distance using the disk summation method. The volume and mean area of ISS became significantly larger, while the largest area became significantly smaller as sampling distance became larger (1.11 mm(2) for 0.125 mm vs. 1.00 mm(2) for 1.0 mm, P for trend=0.036). In addition, variance of difference was positively associated with increasing width of sampling distance. Quantification of ISS is significantly influenced by the applied frequency of SR. This should be taken into account when designing future OFDI studies in which quantitative assessment of ISS is critical for the evaluation of STEMI patients.

SHOX mutations in idiopathic short stature and Leri-Weill dyschondrosteosis: frequency and phenotypic variability.

PubMed

Jorge, Alexander A L; Souza, Silvia C; Nishi, Miriam Y; Billerbeck, Ana E; Libório, Débora C C; Kim, Chong A; Arnhold, Ivo J P; Mendonca, Berenice B

2007-01-01

The frequency of SHOX mutations in children with idiopathic short stature (ISS) has been found to be variable. We analysed the SHOX gene in children with ISS and Leri-Weill dyschondrosteosis (LWD) and evaluated the phenotypic variability in patients harbouring SHOX mutations. Sixty-three ISS, nine LWD children and 21 affected relatives. SHOX gene deletion was evaluated by fluorescence in situ hybridization (FISH), Southern blotting and segregation study of polymorphic marker. Point mutations were assessed by direct DNA sequencing. None of the ISS patients presented SHOX deletions, but two (3.2%) presented heterozygous point mutations, including the novel R147H mutation. However, when ISS patients were selected by sitting height : height ratio (SH/H) for age > 2 SD, mutation frequency detection increased to 22%. Eight (89%) LWD patients had SHOX deletions, but none had point mutations. Analysis of the other relatives in the families carrying SHOX mutations identified 14 children and 17 adult patients. A broad phenotypic variability was observed in all families regarding short stature severity and Madelung deformities. However, the presence of disproportional height, assessed by SH/H, was observed in all children and 82% of adult patients, being the most common feature in our patients with SHOX mutations. Patients with SHOX mutations present a broad phenotypic variability. SHOX mutations are very frequent in LWD (89%), in opposition to ISS (3.2%) in our cohort. The use of SH/H SDS as a selection criterion increases the frequency of SHOX mutation detection to 22% and should be used for selecting ISS children to undergo SHOX mutation molecular studies.

Common exon 3 polymorphism of the GH receptor (GHR) gene and effect of GH therapy on growth in Korean children with idiopathic short stature (ISS).

PubMed

Ko, Jung Min; Park, Jung Young; Yoo, Han-Wook

2009-01-01

A human GH receptor (GHR) gene exon 3 polymorphism (d3-GHR) has been reported to be associated with responsiveness to GH therapy. We assessed the frequencies of this polymorphism in Korean control and idiopathic short stature (ISS) populations, and analysed short-term growth response to GH therapy according to GHR-exon 3 genotypes in Korean children with ISS. This was a retrospective study in 158 ISS children. Auxological and endocrine parameters were measured, and the GHR-exon 3 genotype was analysed. Allelic frequencies of GHR-exon 3 genotype were compared between the ISS group and a control group. GH had been administered for 62 patients, 52 of whom remained prepubertal after the first follow-up year. Changes in height velocity (HV) and IGF-1 and IGFBP-3 concentrations following GH therapy were compared in patients with these genotypes. There was no difference in GHR-exon 3 genotype frequency between ISS and control groups of Koreans. However, the fl/fl genotype was more frequent in Koreans than in Caucasians. ISS children with d3-GHR showed a significantly higher increment in HV (P = 0.002) and a marginally significant increment in IGF-1 concentration (P = 0.064) at the first year of GH therapy. fl-GHR was more frequently detected in a Korean population than in Caucasians. The growth promotion efficacy of GH therapy differed significantly between ISS patients with and without the d3-GHR allele. These findings indicate that the GHR-exon 3 polymorphism can affect the growth promoting efficacy of short-term GH therapy in Korean children with ISS.

Liquid Structures and Physical Properties -- Ground Based Studies for ISS Experiments

NASA Technical Reports Server (NTRS)

Kelton, K. F.; Bendert, J. C.; Mauro, N. A.

2012-01-01

Studies of electrostatically-levitated supercooled liquids have demonstrated strong short- and medium-range ordering in transition metal and alloy liquids, which can influence phase transitions like crystal nucleation and the glass transition. The structure is also related to the liquid properties. Planned ISS experiments will allow a deeper investigation of these results as well as the first investigations of a new type of coupling in crystal nucleation in primary crystallizing liquids, resulting from a linking of the stochastic processes of diffusion with interfacial-attachment. A brief description of the techniques used for ground-based studies and some results relevant to planned ISS investigations are discussed.

Hitchhiker On Space Station

NASA Technical Reports Server (NTRS)

Daelemans, Gerard; Goldsmith, Theodore

1999-01-01

The NASA/GSFC Shuttle Small Payloads Projects Office (SSPPO) has been studying the feasibility of migrating Hitchhiker customers past present and future to the International Space Station via a "Hitchhiker like" carrier system. SSPPO has been tasked to make the most use of existing hardware and software systems and infrastructure in its study of an ISS based carrier system. This paper summarizes the results of the SSPPO Hitchhiker on International Space Station (ISS) study. Included are a number of "Hitchhiker like" carrier system concepts that take advantage of the various ISS attached payload accommodation sites. Emphasis will be given to a HH concept that attaches to the Japanese Experiment Module - Exposed Facility (JEM-EF).

Orbiter Capability for Providing Water to the International Space Station according to the Most Probable Flight Attitudes

NASA Technical Reports Server (NTRS)

Dunaway, Brian; Edeen, Marybeth

2000-01-01

Water to be generated by, delivered to, and processed by the International Space Station (ISS) is a critical Environmental Control and Life Support (ECLS) element, especially for the early ISS missions. A significant portion of the water required by the ISS shall be provided by the Shuttle Transportation System (STS) Orbiter. The balance of water generated by the Orbiter Fuel Cells (FC), minus that water consumed by the Orbiter Flash Evaporator System (FES) and crew, is available for transfer to the ISS. During later missions, crew respired and perspired water, as well as effluent water from the Orbiter LiOH canisters, will be collected as condensate and available for transfer to the ISS. Orbiter radiator performance provides the most variance in determining the amount of net Orbiter water available for transfer to the ISS. As radiator performance decreases, the dependence upon the FES (and FC water) increases for rejecting Orbiter waste heat. Generally, radiator performance decreases as the ISS assembly size increases (especially as solar arrays are added), and also as beta angle increases. ISS solar array deployment necessitates the use of models with articulating solar arrays (for Earth local-vertical attitudes), as array position dramatically affects Orbiter radiator performance. Recent developments in the relaxation of beta angle limitations have also increased the complexity and difficulty of providing water to the ISS. Other factors that may hinder the ability to transfer water are the number of empty Contingency Water Containers (CWCs) available, duration of open-hatch time, crew activity timeline, and full CWC storage capability. A parametric study has been accomplished that provides a quick-reference table for determining expected water generation rates for ISS missions 2A.2 through 7A.1. An hourly Orbiter water generation rate is reported according to a matrix that consists of: (1) (six) significant changes in ISS assembly configuration; (2) (four) beta angles (0 deg. , +37 deg., +53 deg. , and +75 deg.); (3) the (three) most representative ISS attitudes (XPOP-O, XPOP-180 and +XVV); (4) (four) Orbiter radiator configurations (both stowed, starboard deployed, port deployed, and both deployed) and (5) the (two) conditions (radiator inlet temperatures and fuel cell power) most consistent with sleep and wake periods. Those permutations of higher probability of occurrence than others have been identified. Another parametric study has been accomplished that provides a quick-reference table for determining expected water generation rates for ISS assembly complete missions. An hourly Orbiter water generation rate is reported according to a matrix that consists of: (1) (seven) beta angles (-75 deg., -60 deg., -30 deg., 0 deg., +30 deg., +60 deg., and +75 deg.); (2) the (nine) PYR angles that define the corners of the envelope; (3) (four) Orbiter radiator configurations (both stowed, starboard deployed, port deployed, and both deployed) and (4) the (two) conditions (radiator inlet temperatures and fuel cell power) most consistent with sleep and wake periods.

International Space Station (ISS) Anomalies Trending Study. Volume II; Appendices

NASA Technical Reports Server (NTRS)

Beil, Robert J.; Brady, Timothy K.; Foster, Delmar C.; Graber, Robert R.; Malin, Jane T.; Thornesbery, Carroll G.; Throop, David R.

2015-01-01

The NASA Engineering and Safety Center (NESC) set out to utilize data mining and trending techniques to review the anomaly history of the International Space Station (ISS) and provide tools for discipline experts not involved with the ISS Program to search anomaly data to aid in identification of areas that may warrant further investigation. Additionally, the assessment team aimed to develop an approach and skillset for integrating data sets, with the intent of providing an enriched data set for discipline experts to investigate that is easier to navigate, particularly in light of ISS aging and the plan to extend its life into the late 2020s. This document contains the Appendices to the Volume I report.

International Space Station (ISS) Anomalies Trending Study

NASA Technical Reports Server (NTRS)

Beil, Robert J.; Brady, Timothy K.; Foster, Delmar C.; Graber, Robert R.; Malin, Jane T.; Thornesbery, Carroll G.; Throop, David R.

2015-01-01

The NASA Engineering and Safety Center (NESC) set out to utilize data mining and trending techniques to review the anomaly history of the International Space Station (ISS) and provide tools for discipline experts not involved with the ISS Program to search anomaly data to aid in identification of areas that may warrant further investigation. Additionally, the assessment team aimed to develop an approach and skillset for integrating data sets, with the intent of providing an enriched data set for discipline experts to investigate that is easier to navigate, particularly in light of ISS aging and the plan to extend its life into the late 2020s. This report contains the outcome of the NESC Assessment.

A microbial survey of the International Space Station (ISS)

PubMed Central

Lang, Jenna M.; Coil, David A.; Neches, Russell Y.; Brown, Wendy E.; Cavalier, Darlene; Severance, Mark; Hampton-Marcell, Jarrad T.; Gilbert, Jack A.

2017-01-01

Background Modern advances in sequencing technology have enabled the census of microbial members of many natural ecosystems. Recently, attention is increasingly being paid to the microbial residents of human-made, built ecosystems, both private (homes) and public (subways, office buildings, and hospitals). Here, we report results of the characterization of the microbial ecology of a singular built environment, the International Space Station (ISS). This ISS sampling involved the collection and microbial analysis (via 16S rDNA PCR) of 15 surfaces sampled by swabs onboard the ISS. This sampling was a component of Project MERCCURI (Microbial Ecology Research Combining Citizen and University Researchers on ISS). Learning more about the microbial inhabitants of the “buildings” in which we travel through space will take on increasing importance, as plans for human exploration continue, with the possibility of colonization of other planets and moons. Results Sterile swabs were used to sample 15 surfaces onboard the ISS. The sites sampled were designed to be analogous to samples collected for (1) the Wildlife of Our Homes project and (2) a study of cell phones and shoes that were concurrently being collected for another component of Project MERCCURI. Sequencing of the 16S rDNA genes amplified from DNA extracted from each swab was used to produce a census of the microbes present on each surface sampled. We compared the microbes found on the ISS swabs to those from both homes on Earth and data from the Human Microbiome Project. Conclusions While significantly different from homes on Earth and the Human Microbiome Project samples analyzed here, the microbial community composition on the ISS was more similar to home surfaces than to the human microbiome samples. The ISS surfaces are species-rich with 1,036–4,294 operational taxonomic units (OTUs per sample). There was no discernible biogeography of microbes on the 15 ISS surfaces, although this may be a reflection of the small sample size we were able to obtain. PMID:29492330

A microbial survey of the International Space Station (ISS).

PubMed

Lang, Jenna M; Coil, David A; Neches, Russell Y; Brown, Wendy E; Cavalier, Darlene; Severance, Mark; Hampton-Marcell, Jarrad T; Gilbert, Jack A; Eisen, Jonathan A

2017-01-01

Modern advances in sequencing technology have enabled the census of microbial members of many natural ecosystems. Recently, attention is increasingly being paid to the microbial residents of human-made, built ecosystems, both private (homes) and public (subways, office buildings, and hospitals). Here, we report results of the characterization of the microbial ecology of a singular built environment, the International Space Station (ISS). This ISS sampling involved the collection and microbial analysis (via 16S rDNA PCR) of 15 surfaces sampled by swabs onboard the ISS. This sampling was a component of Project MERCCURI (Microbial Ecology Research Combining Citizen and University Researchers on ISS). Learning more about the microbial inhabitants of the "buildings" in which we travel through space will take on increasing importance, as plans for human exploration continue, with the possibility of colonization of other planets and moons. Sterile swabs were used to sample 15 surfaces onboard the ISS. The sites sampled were designed to be analogous to samples collected for (1) the Wildlife of Our Homes project and (2) a study of cell phones and shoes that were concurrently being collected for another component of Project MERCCURI. Sequencing of the 16S rDNA genes amplified from DNA extracted from each swab was used to produce a census of the microbes present on each surface sampled. We compared the microbes found on the ISS swabs to those from both homes on Earth and data from the Human Microbiome Project. While significantly different from homes on Earth and the Human Microbiome Project samples analyzed here, the microbial community composition on the ISS was more similar to home surfaces than to the human microbiome samples. The ISS surfaces are species-rich with 1,036-4,294 operational taxonomic units (OTUs per sample). There was no discernible biogeography of microbes on the 15 ISS surfaces, although this may be a reflection of the small sample size we were able to obtain.

Observed Coupling Between the International Space Station PCU Plasma and a FPMU Langmuir Probe Facilitated by the Geomagnetic Field

NASA Technical Reports Server (NTRS)

Hartman, William; Koontz, Steven L.

2010-01-01

Electrical charging of the International Space Station (ISS) is a matter of serious concern resulting from the possibility of vehicle arcing and electrical shock hazard to crew during extravehicular activity (EVA). A Plasma Contactor Unit (PCU) was developed and integrated into ISS in order to control the ISS floating potential, thereby, minimize vehicle charging and associated hazards. One of the principle factors affecting ISS electrical charging is the ionosphere plasma state (i.e., electron temperature and density). To support ISS electrical charging studies a Floating Potential Monitoring Unit (FPMU) is also integrated into ISS in order to measure the ionosphere properties using Langmuir probes (LP). The FPMU was located on the Starboard side of ISS. The PCU is located near the center of ISS with its plasma exhaust pointed to port. From its integration on ISS in 2006 through November of 2009, the FPMU data exhibited nominal characteristics during PCU operation. On November 21, 2009 the FPMU was relocated from the Starboard location to a new Port location. After relocation significant enhanced noise was observed in both the LP current-voltage sweeps and the derived electron temperature data. The enhanced noise only occurred when the PCU was in discharge and at unique and repeatable locations of the ISS orbit. The cause of this enhanced noise was investigated. It was found that there is coupling occurring between the PCU plasma and the FPMU LP. In this paper we shall 1) present the on-orbit data and the presence of enhanced noise, 2) demonstrate that the coupling of the PCU plasma and the FPMU measurements is geomagnetically organized, 3) show that coupling of the PCU plasma and the FPMU is primarily due to and driven by particle-wave interaction and 4) show that the ionosphere conditions are adequate for Alfven waves to be generated by the PCU plasma.

Assessment of the Impacts of ACLS on the ISS Life Support System Using Dynamic Simulations in V-HAB

NASA Technical Reports Server (NTRS)

Putz, Daniel; Olthoff, Claas; Ewert, Michael; Anderson, Molly

2016-01-01

The Advanced Closed Loop System (ACLS) is currently under development by Airbus Defense and Space and is slated for launch to the International Space Station (ISS) in 2017. The addition of new hardware into an already complex system such as the ISS life support system (LSS) always poses operational risks. It is therefore important to understand the impacts ACLS will have on the existing systems to ensure smooth operations for the ISS. This analysis can be done by using dynamic computer simulations and one possible tool for such a simulation is the Virtual Habitat (V-HAB). Based on MATLAB, V-HAB has been under development at the Institute of Astronautics of the Technical University of Munich (TUM) since 2004 and in the past has been successfully used to simulate the ISS life support systems. The existing V-HAB ISS simulation model treated the interior volume of the space station as one large, ideally-stirred container. This model was improved to allow the calculation of the atmospheric composition inside individual modules of the ISS by splitting it into twelve distinct volumes. The virtual volumes are connected by a simulation of the inter-module ventilation flows. This allows for a combined simulation of the LSS hardware and the atmospheric composition aboard the ISS. A dynamic model of ACLS is added to the ISS Simulation and several different operating modes for both ACLS and the existing ISS life support systems are studied and the impacts of ACLS on the rest of the system are determined. The results suggest that the US, Russian and ACLS CO2 systems can operate at the same time without impeding each other. Furthermore, based on the results of this analysis, the US and ACLS Sabatier systems can be operated in parallel as well to a achieve a very low CO2 concentration in the cabin atmosphere.

Assessment of the Impacts of ACLS on the ISS Life Support System using Dynamic Simulations in V-HAB

NASA Technical Reports Server (NTRS)

Puetz, Daniel; Olthoff, Claas; Ewert, Michael K.; Anderson, Molly S.

2016-01-01

The Advanced Closed Loop System (ACLS) is currently under development by Airbus Defense and Space and is slated for launch to the International Space Station (ISS) in 2017. The addition of new hardware into an already complex system such as the ISS life support system (LSS) always poses operational risks. It is therefore important to understand the impacts ACLS will have on the existing systems to ensure smooth operations for the ISS. This analysis can be done by using dynamic computer simulations and one possible tool for such a simulation is Virtual Habitat (V-HAB). Based on Matlab (Registered Trademark) V-HAB has been under development at the Institute of Astronautics of the Technical University Munich (TUM) since 2006 and in the past has been successfully used to simulate the ISS life support systems. The existing V-HAB ISS simulation model treated the interior volume of the space station as one large ideally-stirred container. This model was improved to allow the calculation of the atmospheric composition inside the individual modules of the ISS by splitting it into ten distinct volumes. The virtual volumes are connected by a simulation of the inter-module ventilation flows. This allows for a combined simulation of the LSS hardware and the atmospheric composition aboard the ISS. A dynamic model of ACLS is added to the ISS simulation and different operating modes for both ACLS and the existing ISS life support systems are studied to determine the impacts of ACLS on the rest of the system. The results suggest that the US, Russian and ACLS CO2 systems can operate at the same time without impeding each other. Furthermore, based on the results of this analysis, the US and ACLS Sabatier systems can be operated in parallel as well to achieve the highest possible CO2 recycling together with a low CO2 concentration.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e308288 - iss042e309536). Shows Earth views taken from a window aboard the International Space Station (ISS).

Inner strength in relation to age, gender and culture among old people--a cross-sectional population study in two Nordic countries.

PubMed

Viglund, Kerstin; Jonsén, Elisabeth; Lundman, Berit; Strandberg, Gunilla; Nygren, Björn

2013-01-01

The theoretical framework for the study was the Model of Inner Strength, and the Inner Strength Scale (ISS)developed based on the Model was used. The aim was to examine inner strength in relation to age, gender and culture among old people in Sweden and Finland. This study forms part of the GErontological Regional DAtabase (GERDA)-Botnia project that investigates healthy ageing with focus on the dignity, social participation and health of old people. The participants (N = 6119) were 65-, 70-, 75- and 80-year old and living in two counties in Sweden or Finland. The ISS consists of 20 items relating to four interrelated dimensions of inner strength, according to the Model of Inner Strength. The range of possible ISS scores is 20-120, a higher score denoting higher inner strength. The result showed that the 65-year-old participants had the highest mean ISS score, with a decrease in score for every subsequent age. The lowest score was achieved by the 80-year-old participants. Women had slightly but significantly higher mean ISS scores than men. Only small differences were found between the counties. The study population came from Sweden and Finland; still, despite the different backgrounds, patterns in the distribution of inner strength were largely similar. The present study provides basic and essential information about inner strength in a population of old people.

The impact of the AIS 2005 revision on injury severity scores and clinical outcome measures.

PubMed

Salottolo, Kristin; Settell, April; Uribe, Phyllis; Akin, Shelley; Slone, Denetta Sue; O'Neal, Erika; Mains, Charles; Bar-Or, David

2009-09-01

The abbreviated injury scale (AIS) was updated in 2005 from the AIS 1998 version. The purpose of this study is to describe the effects of this change on injury severity scoring and outcome measures. Analyses were performed on all trauma patients consecutively admitted over a 6-month period at two geographically separate Level I trauma centers. Injuries were manually double-coded according to the AIS 05 and the AIS 98. Changes in AIS, ISS, and new ISS (NISS) were analysed using paired t-tests. Apparent differences in outcome by ISS strata (<16, 16-24, >24) were compared for AIS 05 versus AIS 98 using the Wald-type statistic. Lastly, the percent of patients with a change in ISS strata are reported. There were 2250 patients included in the study. Nearly half (46.4%) of AIS codes changed, resulting in a different AIS score for 18.9% of all codes. The mean ISS was significantly lower using the AIS 05 (11.7) versus the AIS 98 (13.3, p<0.001). Similarly, the mean NISS was significantly lower (16.3 versus 18.7, p<0.001). In the ISS strata 16-24 an apparent increase in mortality, length of stay, and percent of patients not discharged home was observed for the AIS 05 versus AIS 98. Changes in outcome measures for this stratum were as follows (AIS 98 versus AIS 05): mortality, 4.3% versus 7.7% (p=0.002); hospital length of stay, 5.2 days versus 7.3 days (p<0.001); percent of patients not discharged home, 39.2% versus 49.3% (p<0.001). Finally, there was a 20.5% reduction in patients with an ISS>or=16 and a 26.2% reduction in patients with an ISS>or=25 using the AIS 05. The AIS revision had a significant impact on overall injury severity measures, clinical outcome measures, and percent of patients in each ISS strata. Therefore, the AIS revision affects the ability to directly compare data generated using AIS 05 and AIS 98 which has implications in trauma research, reimbursement and ACS accreditation.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2014-09-29

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss041e37762 - iss041e39788). Shows Earth and aurora views. Partial views of ISS in and out of view.

Impact of the severity of trauma on early retirement.

PubMed

Kuhlman, Michael Bilde; Lohse, Nicolai; Sørensen, Anne Marie; Larsen, Claus Falck; Christensen, Karl Bang; Steinmetz, Jacob

2014-03-01

To assess the association between Injury Severity Score (ISS) and subsequent risk of early retirement. Observational cohort study with follow-up based on prospectively collected data. Hospital-based data were linked to national register data on pension reception and vital status. Level-one urban trauma centre. Patients aged 18-64 years entering the trauma centre in Copenhagen during 1999-2007 who were alive after three days were followed until early retirement, death or emigration. Primary outcome was early retirement, defined as receiving disability pension (unintentional) or voluntary early retirement pension (intentional) before the regular age of retirement (65 years). Relative risk of early retirement according to ISS (low, ISS 1-15 vs. high, ISS 16-75) was assessed using Cox proportional hazards regression, adjusted for age and gender. Of all 6687 patients admitted to the trauma centre, a total of 1722 trauma patients were included and followed for a median of 6.2 years (interquartile range (IQR) 3.7-9.1). Of these, 1305 (75.8%) were males, median age was 35.0 years (IQR 25.4-46.5), and median ISS was 16 (IQR 9-25). Three hundred and twenty-two patients retired during follow-up. Patients with high ISS, compared to patients with low ISS, had an increased risk of early retirement, adjusted hazard ratio 2.60 (95% confidence interval (CI) 2.05-3.30; p<0.001). Relative increase in retirement risk was 1.04 (95% CI 1.03-1.05) per ISS point and 1.03 (95% CI 1.03-1.04) per year older. Gender was not found to be a significant risk factor (p=0.69). Five-year absolute risks of early retirement were 9.9% (95% CI 7.8-12.0%) for the low ISS group and 24.6% (95% CI 21.6-27.5%) for the high ISS group. The risk of early retirement is 2.6 times higher in severely injured patients (ISS 16-75) than the risk in low to moderately injured patients (ISS 1-15) and they have a high absolute 5-year risk as well. Early, targeted interventions to assist with return to work might be able to reduce this risk. Copyright © 2013 Elsevier Ltd. All rights reserved.

The International Scoring System (ISS) for multiple myeloma remains a robust prognostic tool independently of patients' renal function.

PubMed

Dimopoulos, M A; Kastritis, E; Michalis, E; Tsatalas, C; Michael, M; Pouli, A; Kartasis, Z; Delimpasi, S; Gika, D; Zomas, A; Roussou, M; Konstantopoulos, K; Parcharidou, A; Zervas, K; Terpos, E

2012-03-01

The International Staging System (ISS) is the most widely used staging system for patients with multiple myeloma (MM). However, serum β2-microglobulin increases in renal impairment (RI) and there have been concerns that ISS-3 stage may include 'up-staged' MM patients in whom elevated β2-microglobulin reflects the degree of renal dysfunction rather than tumor load. In order to assess the impact of RI on the prognostic value of ISS, we analyzed 1516 patients with symptomatic MM and the degree of RI was classified according to the Kidney Disease Outcomes Quality Initiative-Chronic Kidney Disease (CKD) criteria. Forty-eight percent patients had stages 3-5 CKD while 29% of patients had ISS-1, 38% had ISS-2 and 33% ISS-3. The frequency and severity of RI were more common in ISS-3 patients. RI was associated with inferior survival in univariate but not in multivariate analysis. When analyzed separately, ISS-1 and ISS-2 patients with RI had inferior survival in univariate but not in multivariate analysis. In ISS-3 MM patients, RI had no prognostic impact either in univariate or multivariate analysis. Results were similar, when we analyzed only patients with Bence-Jones >200 mg/day. ISS remains unaffected by the degree of RI, even in patients with ISS-3, which includes most patients with renal dysfunction.

Individualized Study Systems in Theory and Practice

ERIC Educational Resources Information Center

van der Klauw, C. F.; Plomp, Tj

1974-01-01

After a short characterization of individualized study systems (ISS) and a survey of the number and subject fields of individualized courses in the USA and Europe, the construction and evaluation of an ISS system in freshman mathematics at the Twente University of Technology, in the Netherlands, is discussed. (Editor)

Whole metagenome profiles of particulates collected from the International Space Station

DOE PAGES

Be, Nicholas A.; Avila-Herrera, Aram; Allen, Jonathan E.; ...

2017-07-17

Background The built environment of the International Space Station (ISS) is a highly specialized space in terms of both physical characteristics and habitation requirements. It is unique with respect to conditions of microgravity, exposure to space radiation, and increased carbon dioxide concentrations. Additionally, astronauts inhabit a large proportion of this environment. The microbial composition of ISS particulates has been reported; however, its functional genomics, which are pertinent due to potential impact of its constituents on human health and operational mission success, are not yet characterized. Methods This study examined the whole metagenome of ISS microbes at both species- and gene-levelmore » resolution. Air filter and dust samples from the ISS were analyzed and compared to samples collected in a terrestrial cleanroom environment. Furthermore, metagenome mining was carried out to characterize dominant, virulent, and novel microorganisms. The whole genome sequences of select cultivable strains isolated from these samples were extracted from the metagenome and compared. Results Species-level composition in the ISS was found to be largely dominated by Corynebacterium ihumii GD7, with overall microbial diversity being lower in the ISS relative to the cleanroom samples. When examining detection of microbial genes relevant to human health such as antimicrobial resistance and virulence genes, it was found that a larger number of relevant gene categories were observed in the ISS relative to the cleanroom. Strain-level cross-sample comparisons were made for Corynebacterium, Bacillus, and Aspergillus showing possible distinctions in the dominant strain between samples. Conclusion Species-level analyses demonstrated distinct differences between the ISS and cleanroom samples, indicating that the cleanroom population is not necessarily reflective of space habitation environments. Lastly, the overall population of viable microorganisms and the functional diversity inherent to this unique closed environment are of critical interest with respect to future space habitation. Observations and studies such as these will be important to evaluating the conditions required for long-term health of human occupants in such environments.« less

Whole metagenome profiles of particulates collected from the International Space Station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Be, Nicholas A.; Avila-Herrera, Aram; Allen, Jonathan E.

Background The built environment of the International Space Station (ISS) is a highly specialized space in terms of both physical characteristics and habitation requirements. It is unique with respect to conditions of microgravity, exposure to space radiation, and increased carbon dioxide concentrations. Additionally, astronauts inhabit a large proportion of this environment. The microbial composition of ISS particulates has been reported; however, its functional genomics, which are pertinent due to potential impact of its constituents on human health and operational mission success, are not yet characterized. Methods This study examined the whole metagenome of ISS microbes at both species- and gene-levelmore » resolution. Air filter and dust samples from the ISS were analyzed and compared to samples collected in a terrestrial cleanroom environment. Furthermore, metagenome mining was carried out to characterize dominant, virulent, and novel microorganisms. The whole genome sequences of select cultivable strains isolated from these samples were extracted from the metagenome and compared. Results Species-level composition in the ISS was found to be largely dominated by Corynebacterium ihumii GD7, with overall microbial diversity being lower in the ISS relative to the cleanroom samples. When examining detection of microbial genes relevant to human health such as antimicrobial resistance and virulence genes, it was found that a larger number of relevant gene categories were observed in the ISS relative to the cleanroom. Strain-level cross-sample comparisons were made for Corynebacterium, Bacillus, and Aspergillus showing possible distinctions in the dominant strain between samples. Conclusion Species-level analyses demonstrated distinct differences between the ISS and cleanroom samples, indicating that the cleanroom population is not necessarily reflective of space habitation environments. Lastly, the overall population of viable microorganisms and the functional diversity inherent to this unique closed environment are of critical interest with respect to future space habitation. Observations and studies such as these will be important to evaluating the conditions required for long-term health of human occupants in such environments.« less

A comparison of the Injury Severity Score and the Trauma Mortality Prediction Model.

PubMed

Cook, Alan; Weddle, Jo; Baker, Susan; Hosmer, David; Glance, Laurent; Friedman, Lee; Osler, Turner

2014-01-01

Performance benchmarking requires accurate measurement of injury severity. Despite its shortcomings, the Injury Severity Score (ISS) remains the industry standard 40 years after its creation. A new severity measure, the Trauma Mortality Prediction Model (TMPM), uses either the Abbreviated Injury Scale (AIS) or DRG International Classification of Diseases-9th Rev. (ICD-9) lexicons and may better quantify injury severity compared with ISS. We compared the performance of TMPM with ISS and other measures of injury severity in a single cohort of patients. We included 337,359 patient records with injuries reliably described in both the AIS and the ICD-9 lexicons from the National Trauma Data Bank. Five injury severity measures (ISS, maximum AIS score, New Injury Severity Score [NISS], ICD-9-Based Injury Severity Score [ICISS], TMPM) were computed using either the AIS or ICD-9 codes. These measures were compared for discrimination (area under the receiver operating characteristic curve), an estimate of proximity to a model that perfectly predicts the outcome (Akaike information criterion), and model calibration curves. TMPM demonstrated superior receiver operating characteristic curve, Akaike information criterion, and calibration using either the AIS or ICD-9 lexicons. Calibration plots demonstrate the monotonic characteristics of the TMPM models contrasted by the nonmonotonic features of the other prediction models. Severity measures were more accurate with the AIS lexicon rather than ICD-9. NISS proved superior to ISS in either lexicon. Since NISS is simpler to compute, it should replace ISS when a quick estimate of injury severity is required for AIS-coded injuries. Calibration curves suggest that the nonmonotonic nature of ISS may undermine its performance. TMPM demonstrated superior overall mortality prediction compared with all other models including ISS whether the AIS or ICD-9 lexicons were used. Because TMPM provides an absolute probability of death, it may allow clinicians to communicate more precisely with one another and with patients and families. Disagnostic study, level I; prognostic study, level II.

Whole metagenome profiles of particulates collected from the International Space Station.

PubMed

Be, Nicholas A; Avila-Herrera, Aram; Allen, Jonathan E; Singh, Nitin; Checinska Sielaff, Aleksandra; Jaing, Crystal; Venkateswaran, Kasthuri

2017-07-17

The built environment of the International Space Station (ISS) is a highly specialized space in terms of both physical characteristics and habitation requirements. It is unique with respect to conditions of microgravity, exposure to space radiation, and increased carbon dioxide concentrations. Additionally, astronauts inhabit a large proportion of this environment. The microbial composition of ISS particulates has been reported; however, its functional genomics, which are pertinent due to potential impact of its constituents on human health and operational mission success, are not yet characterized. This study examined the whole metagenome of ISS microbes at both species- and gene-level resolution. Air filter and dust samples from the ISS were analyzed and compared to samples collected in a terrestrial cleanroom environment. Furthermore, metagenome mining was carried out to characterize dominant, virulent, and novel microorganisms. The whole genome sequences of select cultivable strains isolated from these samples were extracted from the metagenome and compared. Species-level composition in the ISS was found to be largely dominated by Corynebacterium ihumii GD7, with overall microbial diversity being lower in the ISS relative to the cleanroom samples. When examining detection of microbial genes relevant to human health such as antimicrobial resistance and virulence genes, it was found that a larger number of relevant gene categories were observed in the ISS relative to the cleanroom. Strain-level cross-sample comparisons were made for Corynebacterium, Bacillus, and Aspergillus showing possible distinctions in the dominant strain between samples. Species-level analyses demonstrated distinct differences between the ISS and cleanroom samples, indicating that the cleanroom population is not necessarily reflective of space habitation environments. The overall population of viable microorganisms and the functional diversity inherent to this unique closed environment are of critical interest with respect to future space habitation. Observations and studies such as these will be important to evaluating the conditions required for long-term health of human occupants in such environments.

Assessment and Control of Spacecraft Charging Risks on the International Space Station

NASA Technical Reports Server (NTRS)

Koontz, Steve; Valentine, Mark; Keeping, Thomas; Edeen, Marybeth; Spetch, William; Dalton, Penni

2004-01-01

The International Space Station (ISS) operates in the F2 region of Earth's ionosphere, orbiting at altitudes ranging from 350 to 450 km at an inclination of 51.6 degrees. The relatively dense, cool F2 ionospheric plasma suppresses surface charging processes much of the time, and the flux of relativistic electrons is low enough to preclude deep dielectric charging processes. The most important spacecraft charging processes in the ISS orbital environment are: 1) ISS electrical power system interactions with the F2 plasma, 2) magnetic induction processes resulting from flight through the geomagnetic field and, 3) charging processes that result from interaction with auroral electrons at high latitude. Recently, the continuing review and evaluation of putative ISS charging hazards required by the ISS Program Office revealed that ISS charging could produce an electrical shock hazard to the ISS crew during extravehicular activity (EVA). ISS charging risks are being evaluated in an ongoing measurement and analysis campaign. The results of ISS charging measurements are combined with a recently developed model of ISS charging (the Plasma Interaction Model) and an exhaustive analysis of historical ionospheric variability data (ISS Ionospheric Specification) to evaluate ISS charging risks using Probabilistic Risk Assessment (PRA) methods. The PRA combines estimates of the frequency of occurrence and severity of the charging hazards with estimates of the reliability of various hazard controls systems, as required by NASA s safety and risk management programs, to enable design and selection of a hazard control approach that minimizes overall programmatic and personnel risk. The PRA provides a quantitative methodology for incorporating the results of the ISS charging measurement and analysis campaigns into the necessary hazard reports, EVA procedures, and ISS flight rules required for operating ISS in a safe and productive manner.

Prediction, Measurement, and Control of Spacecraft Charging Hazards on the International Space Station(ISS)

NASA Astrophysics Data System (ADS)

Koontz, Steve; Alred, John; Ellison, Amy; Patton, Thomas; Minow, Joseph; Spetch, William

2010-09-01

Orbital inclination, 51.6 degrees, and altitude range, 300 to 400 km,(low-Earth orbit or LEO) determine the ISS spacecraft charging environment. Specific interactions of the ISS electrical power system and metallic structure with the Earth’s ionospheric plasma and the geomagnetic field dominate spacecraft charging processes for ISS. ISS also flies through auroral electron streams at high latitudes. In this paper, we report the character of ISS spacecraft charging processes in Earth’s ionosphere, the results of measurement and modelling of the subject charging processes, and the safety issues for ISS itself as well as for ISS interoperability with respect to extra vehicular activity(EVA) and visiting vehicle proximity operations.

The Abbreviated Injury Scale and its correlation with preventable traumatic accidental deaths: a study from South Delhi.

PubMed

Rautji, R; Bhardwaj, D N; Dogra, T D

2006-04-01

Anatomic trauma scoring systems are fundamental to trauma research. The Abbreviated Injury Scale (AIS) and its derivative, the Injury Severity Score (ISS), are the most frequently used scales. In a prospective study, 400 autopsies of road traffic accident victims performed between January 2002 and December 2003 were coded according to the AIS and ISS methods. All the cases were classified into different injury groups according to the Injury Severity Scale. Fifty-eight cases (14.5%) were assigned an ISS value of <25; 244 (61%) cases were valued between 25-49; 38 cases (9.5%) were valued between 50-74 and 60 (15%) cases had a value of 75. On analysis of medical care, in cases with ISS<50, about 96% of the victims did not receive optimal care quickly enough with a lack of pre-hospital resuscitation measures and lengthy transportation time to hospital being of major importance.

Exploration-Related Research on ISS: Connecting Science Results to Future Missions

NASA Technical Reports Server (NTRS)

Rhatigan, Jennifer L.; Robinson, Julie A.; Sawin, Charles F.

2005-01-01

In January, 2004, the U.S. President announced The Vision for Space Exploration, and charged the National Aeronautics and Space Administration (NASA) with using the International Space Station (ISS) for research and technology targeted at supporting U.S. space exploration goals. This paper describes: What we have learned from the first four years of research on ISS relative to the exploration mission; The on-going research being conducted in this regard; and Our current understanding of the major exploration mission risks that the ISS can be used to address. Specifically, we discuss research carried out on the ISS to determine the mechanisms by which human health is affected on long-duration missions, and to develop countermeasures to protect humans from the space environment. These bioastronautics experiments are key enablers of future long duration human exploration missions. We also discuss how targeted technological developments can enable mission design trade studies. We discuss the relationship between the ultimate number of human test subjects available on the ISS to the quality and quantity of scientific insight that can be used to reduce health risks to future explorers. We discuss the results of NASA's efforts over the past year to realign the ISS research programs to support a product-driven portfolio that is directed towards reducing the major risks of exploration missions. The fundamental challenge to science on ISS is completing experiments that answer key questions in time to shape design decisions for future exploration. In this context, exploration relevant research must do more than be conceptually connected to design decisions - it must become a part of the mission design process.

Clinical and molecular evaluation of SHOX/PAR1 duplications in Leri-Weill dyschondrosteosis (LWD) and idiopathic short stature (ISS).

PubMed

Benito-Sanz, S; Barroso, E; Heine-Suñer, D; Hisado-Oliva, A; Romanelli, V; Rosell, J; Aragones, A; Caimari, M; Argente, J; Ross, J L; Zinn, A R; Gracia, R; Lapunzina, P; Campos-Barros, A; Heath, K E

2011-02-01

Léri-Weill dyschondrosteosis (LWD) is a skeletal dysplasia characterized by disproportionate short stature and the Madelung deformity of the forearm. SHOX mutations and pseudoautosomal region 1 deletions encompassing SHOX or its enhancers have been identified in approximately 60% of LWD and approximately 15% of idiopathic short stature (ISS) individuals. Recently SHOX duplications have been described in LWD/ISS but also in individuals with other clinical manifestations, thus questioning their pathogenicity. The objective of the study was to investigate the pathogenicity of SHOX duplications in LWD and ISS. Multiplex ligation-dependent probe amplification is routinely used in our unit to analyze for SHOX/pseudoautosomal region 1 copy number changes in LWD/ISS referrals. Quantitative PCR, microsatellite marker, and fluorescence in situ hybridization analysis were undertaken to confirm all identified duplications. During the routine analysis of 122 LWD and 613 ISS referrals, a total of four complete and 10 partial SHOX duplications or multiple copy number (n > 3) as well as one duplication of the SHOX 5' flanking region were identified in nine LWD and six ISS cases. Partial SHOX duplications appeared to have a more deleterious effect on skeletal dysplasia and height gain than complete SHOX duplications. Importantly, no increase in SHOX copy number was identified in 340 individuals with normal stature or 104 overgrowth referrals. MLPA analysis of SHOX/PAR1 led to the identification of partial and complete SHOX duplications or multiple copies associated with LWD or ISS, suggesting that they may represent an additional class of mutations implicated in the molecular etiology of these clinical entities.

ISS/IDS Detector Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cervera-Villanueva, A.

2008-02-21

This article summarises the results obtained by the detector working group of the 'International Scooping Study' (ISS) of a future neutrino oscillations facility. Special emphasis is put on far detectors, for which some of the main issues are identified. A detector R and D strategy in the context of the 'International Design Study' (IDS) for a neutrino factory is also presented.

Study of the leptin levels and its gene polymorphisms in patients with idiopathic short stature and growth hormone deficiency.

PubMed

Su, Pen-Hua; Yang, Shun-Fa; Yu, Ju-Shan; Chen, Suh-Jen; Chen, Jia-Yuh

2012-08-01

Leptin levels may regulate fat metabolism, skeletal growth, and puberty. Leptin gene variants affect risk of obesity, cancer, but their effect on onset of growth hormone deficiency (GHD) and idiopathic short stature (ISS) is unknown. We tested the hypothesis that the phenotype of GHD and ISS may be associated with polymorphism in the leptin gene. The prevalence of a single nucleotide polymorphism (SNP) in the leptin gene (LEP) promoter at -2548 and the leptin and insulin growth factor-1 (IGF-1) concentrations in GHD and ISS were compared to those of healthy controls. IGF-1 and leptin concentrations were significantly lower in both the GHD and ISS groups than in the control group. The ISS and GHD groups had a significantly different distribution of SNP alleles at the LEP -2548 (P = 0.010). Individuals with LEP -2548A/G or G/G genotype in ISS group (47.5%) showed a significantly lower weight and body mass index (BMI) (but not leptin levels) than individuals carrying the A/A genotype (52.5%). LEP -2548A/A in GHD patients (65.8%) was associated with lower weight, BMI, leptin concentrations than those of individuals carrying the A/G or G/G genotype (34.2%). These data suggest that the LEP -2548A polymorphism may associate with the weight and BMI of the children with ISS and GHD.

The injury severity score or the new injury severity score for predicting mortality, intensive care unit admission and length of hospital stay: experience from a university hospital in a developing country.

PubMed

Tamim, Hala; Al Hazzouri, Adina Zeki; Mahfoud, Ziad; Atoui, Maria; El-Chemaly, Souheil

2008-01-01

Limited research has been performed to compare the predictive abilities of the injury severity score (ISS) and the new ISS (NISS) in the developing world. From January 2001 until January 2003 all trauma patients admitted to the American University of Beirut Medical Centre were enrolled. The statistical performance of the ISS/NISS in predicting mortality, admission to the intensive care unit (ICU) and length of hospital stay (LOS dichotomised as <10 or > or =10 days) was evaluated using receiver operating characteristic and the Hosmer-Lemeshow calibration statistic. A total of 891 consecutive patients were enrolled. The ISS and NISS were equivalent in predicting survival, and both performed better in patients younger than 65 years of age. However, the ISS predicted ICU admission and LOS better than the NISS. However, these predictive abilities were lower for the geriatric trauma patients aged 65 years and above compared to the other age groups. There are conflicting results in the literature about the abilities of ISS and NISS to predict mortality. However, this is the first study to report that ISS has a superior ability in predicting both LOS and ICU admission. The scoring of trauma severity may need to be individualised to different countries and trauma systems.

The impact of specialist trauma service on major trauma mortality.

PubMed

Wong, Ting Hway; Lumsdaine, William; Hardy, Benjamin M; Lee, Keegan; Balogh, Zsolt J

2013-03-01

Trauma services throughout the world have had positive effects on trauma-related mortality. Australian trauma services are generally more consultative in nature rather than the North American model of full trauma admission service. We hypothesized that the introduction of a consultative specialist trauma service in a Level I Australian trauma center would reduce mortality of the severely injured. A 10-year retrospective study (January 1, 2002-December 31, 2011) was performed on all trauma patients admitted with an Injury Severity Score (ISS) > 15. Patients were identified from the trauma registry, and data for age, sex, mechanism of injury, ISS, survival to discharge, and length of stay were collected. Mortality was examined for patients with severe injury (ISS > 15) and patients with critical injury (ISS > 24) and compared for the three periods: 2002-2004 (without trauma specialist), 2005-2007 (with trauma specialist), and 2008-2011 (with specialist trauma service). A total of 3,869 severely injured (ISS > 15) trauma patients were identified during the 10-year period. Of these, 2,826 (73%) were male, 1,513 (39%) were critically injured (ISS > 24), and more than 97% (3,754) were the victim of blunt trauma. Overall mortality decreased from 12.4% to 9.3% (relative risk, 0.75) from period one to period three and from 25.4% to 20.3% (relative risk, 0.80) for patients with critical injury. A 0.46% per year decrease (p = 0.018) in mortality was detected (odds ratio, 0.63; p < 0.001). For critically injured (ISS > 24), the trend was (0.61% per year; odds ratio, 0.68; p = 0.039). The introduction of a specialist trauma service decreased the mortality of patients with severe injury, the model of care should be considered to implement state- and nationwide in Australia. Epidemiologic study, level III.

Scoring of anatomic injury after trauma: AIS 98 versus AIS 90--do the changes affect overall severity assessment?

PubMed

Skaga, Nils O; Eken, Torsten; Hestnes, Morten; Jones, J Mary; Steen, Petter A

2007-01-01

Although several changes were implemented in the 1998 update of the abbreviated injury scale (AIS 98) versus the previous AIS 90, both are still used worldwide for coding of anatomic injury in trauma. This could possibly invalidate comparisons between systems using different AIS versions. Our aim was to evaluate whether the use of different coding dictionaries affected estimation of Injury Severity Score (ISS), New Injury Severity Score (NISS) and probability of survival (Ps) according to TRISS in a hospital-based trauma registry. In a prospective study including 1654 patients from Ulleval University Hospital, a Norwegian trauma referral centre, patients were coded according to both AIS 98 and AIS 90. Agreement between the classifications of ISS, NISS and Ps according to TRISS methodology was estimated using intraclass correlation coefficients (ICC) with 95% CI. ISS changed for 378 of 1654 patients analysed (22.9%). One hundred and forty seven (8.9%) were coded differently due to different injury descriptions and 369 patients (22.3%) had a change in ISS value in one or more regions due to the different scoring algorithm for skin injuries introduced in AIS 98. This gave a minimal change in mean ISS (14.74 versus 14.54). An ICC value of 0.997 (95% CI 0.9968-0.9974) for ISS indicates excellent agreement between the scoring systems. There were no significant changes in NISS and Ps. There was excellent agreement for the overall population between ISS, NISS and Ps values obtained using AIS 90 and AIS 98 for injury coding. Injury descriptions for hypothermia were re-introduced in the recently published AIS 2005. We support this change as coding differences due to hypothermia were encountered in 4.3% of patients in the present study.

iss047e012492

NASA Image and Video Library

2016-03-21

ISS047e012492 (03/21/2016) --- NASA astronaut Tim Kopra stows hardware from the OASIS experiment aboard the International Space Station. OASIS, which stands for Observation and Analysis of Smectic Islands In Space, studies the unique behavior of liquid crystals in microgravity.

Q-PCR based bioburden assessment of drinking water throughout treatment and delivery to the International Space Station

NASA Technical Reports Server (NTRS)

Newcombe, David; Stuecker, Tara; La Duc, Myron; Venkateswaran, Kasthuri

2005-01-01

Previous studies indicated evidence of opportunistic pathogens samples obtained during missions to the International Space Station (ISS). This study utilized TaqMan quantitative PCR to determine specific gene abundance in potable and non-potable ISS waters. Probe and primer sets specific to the small subunit rRNA genes were used to elucidate overall bacterial rRNA gene numbers. while those specific for Burkholderia cepacia and Stenotrophomonas maltophilia were optimized and used to probe for the presence of these two opportunistic pathogens. This research builds upon previous microbial diversity studies of ISS water and demonstrates the utility of Q-PCR tool to examine water quality.

Developing a burn injury severity score (BISS): adding age and total body surface area burned to the injury severity score (ISS) improves mortality concordance.

PubMed

Cassidy, J Tristan; Phillips, Michael; Fatovich, Daniel; Duke, Janine; Edgar, Dale; Wood, Fiona

2014-08-01

There is limited research validating the injury severity score (ISS) in burns. We examined the concordance of ISS with burn mortality. We hypothesized that combining age and total body surface area (TBSA) burned to the ISS gives a more accurate mortality risk estimate. Data from the Royal Perth Hospital Trauma Registry and the Royal Perth Hospital Burns Minimum Data Set were linked. Area under the receiver operating characteristic curve (AUC) measured concordance of ISS with mortality. Using logistic regression models with death as the dependent variable we developed a burn-specific injury severity score (BISS). There were 1344 burns with 24 (1.8%) deaths, median TBSA 5% (IQR 2-10), and median age 36 years (IQR 23-50). The results show ISS is a good predictor of death for burns when ISS≤15 (OR 1.29, p=0.02), but not for ISS>15 (ISS 16-24: OR 1.09, p=0.81; ISS 25-49: OR 0.81, p=0.19). Comparing the AUCs adjusted for age, gender and cause, ISS of 84% (95% CI 82-85%) and BISS of 95% (95% CI 92-98%), demonstrated superior performance of BISS as a mortality predictor for burns. ISS is a poor predictor of death in severe burns. The BISS combines ISS with age and TBSA and performs significantly better than the ISS. Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved.

International Research Results and Accomplishments From the International Space Station

NASA Technical Reports Server (NTRS)

Ruttley, Tara M.; Robinson, Julie A.; Tate-Brown, Judy; Perkins, Nekisha; Cohen, Luchino; Marcil, Isabelle; Heppener, Marc; Hatton, Jason; Tasaki, Kazuyuki; Umemura, Sayaka;

International Research Results and Accomplishments From the International Space Station - A New Compilation

NASA Technical Reports Server (NTRS)

Ruttley, Tara; Robinson, Julie A.; Tate-Brown, Judy; Perkins, Nekisha; Cohen, Luchino; Marcil, Isabelle; Heppener, Marc; Hatton, Jason; Tasaki, Kazuyuki; Umemura, Sayaka;

Environmental "Omics" of International Space Station: Insights, Significance, and Consequences

NASA Astrophysics Data System (ADS)

Venkateswaran, Kasthuri

2016-07-01

The NASA Space Biology program funded two multi-year studies to catalogue International Space Station (ISS) environmental microbiome. The first Microbial Observatory (MO) experiment will generate a microbial census of the ISS surfaces and atmosphere using advanced molecular microbial community analysis "omics" techniques, supported by traditional culture-based methods and state-of-the art molecular techniques. The second MO experiment will measure presence of viral and select bacterial and fungal pathogens on ISS surfaces and correlate their presence on crew. The "omics" methodologies of the MO experiments will serve as the foundation for an extensive microbial census, offering significant insight into spaceflight-induced changes in the populations of beneficial and potentially harmful microbes. The safety of crewmembers and the maintenance of hardware are the primary goals for monitoring microorganisms in this closed habitat. The statistical analysis of the ISS microbiomes showed that three bacterial phyla dominated both in ISS and Earth cleanrooms, but varied in their abundances. While members of Actinobacteria were predominant on ISS, Proteobacteria dominated the Earth cleanrooms. Alpha diversity estimators indicated a significant drop in viable microbial diversity. To better characterize the shared community composition among samples, beta-diversity metrics analysis were conducted. At the bacterial species level characterization, the microbial community composition is strongly associated with sampling site. Results of the study indicate significant differences between ISS and Earth cleanroom microbiomes in terms of community structure and composition. Bacterial strains isolated from ISS surfaces were also tested for their resistance to nine antibiotics using conventional disc method and Vitek 2 system. Most of the Staphylococcus aureus strains were resistant to penicillin. Five strains were specifically resistant to erythromycin and the ermA gene was also detected. The nine-erythromycin sensitive S. aureus strains exhibited spontaneous mutation when rifampin was tested. Some of the S. aureus strains tolerated gentamycin and tobramycin but cefazolin, cefoxitin, ciprofloxacin and oxacillin inhibited the growth of the S. aureus. Whole genome sequencing (WGS) of 21 ISS strains, exhibiting resistance to various antibiotics, was carried out. The antibiotic resistant genes deduced from the WGS were compared with the resistomes generated directly from the gene pool of the environmental samples. Using a targeted amplification panel consisting of over 500 antimicrobial resistance genes, we were able to confirm the results of the phenotypic assays. Specifically, the presence of multiple β-lactamase genes was observed. The class A β-lactamase genes, tem-1 (ampicillin-resistance) and ctx-M-14 (cefotaxime conferring gene), were found in multiple sites of ISS. In addition, presence of mecA gene (penicillin clusters) was confirmed in several sampling locations from both ISS flights. Finally, the existence of the ermA gene (erythromycin) was established. These results suggest widespread and consistent distribution of multiple antibiotic resistance genes throughout the ISS. The resistome data generated via molecular methods will be extremely important in determining the microbial significance to the crew health and the ISS maintenance. These data sets will be placed in the NASA GeneLab bioinformatics environment - consisting of a database, computational tools, and improved methods - that would subsequently be made open to the scientific research community to encourage innovation.

Correlation of ISS Electric Potential Variations with Mission Operations

NASA Technical Reports Server (NTRS)

Willis, Emily M.; Minow, Joseph I.; Parker, Linda Neergaard

2014-01-01

Spacecraft charging on the International Space Station (ISS) is caused by a complex combination of the low Earth orbit plasma environment, space weather events, operations of the high voltage solar arrays, and changes in the ISS configuration and orbit parameters. Measurements of the ionospheric electron density and temperature along the ISS orbit and variations in the ISS electric potential are obtained from the Floating Potential Measurement Unit (FPMU) suite of four plasma instruments (two Langmuir probes, a Floating Potential Probe, and a Plasma Impedance Probe) on the ISS. These instruments provide a unique capability for monitoring the response of the ISS electric potential to variations in the space environment, changes in vehicle configuration, and operational solar array power manipulation. In particular, rapid variations in ISS potential during solar array operations on time scales of tens of milliseconds can be monitored due to the 128 Hz sample rate of the Floating Potential Probe providing an interesting insight into high voltage solar array interaction with the space plasma environment. Comparing the FPMU data with the ISS operations timeline and solar array data provides a means for correlating some of the more complex and interesting ISS electric potential variations with mission operations. In addition, recent extensions and improvements to the ISS data downlink capabilities have allowed more operating time for the FPMU than ever before. The FPMU was operated for over 200 days in 2013 resulting in the largest data set ever recorded in a single year for the ISS. In this paper we provide examples of a number of the more interesting ISS charging events observed during the 2013 operations including examples of rapid charging events due to solar array power operations, auroral charging events, and other charging behavior related to ISS mission operations.

Correlation of ISS Electric Potential Variations with Mission Operations

NASA Technical Reports Server (NTRS)

Willis, Emily M.; Minow, Joseph I.; Parker, Linda Neergaard

2014-01-01

Spacecraft charging on the International Space Station (ISS) is caused by a complex mix of the low Earth orbit plasma environment, space weather events, operations of the high voltage solar arrays, and changes in the ISS configuration and orbit parameters. Measurements of the ionospheric electron density and temperature along the ISS orbit and variations in the ISS electric potential are obtained from the Floating Potential Measurement Unit (FPMU) suite of four plasma instruments (two Langmuir probes, a Floating Potential Probe, and a Plasma Impedance Probe) on the ISS. These instruments provide a unique capability for monitoring the response of the ISS electric potential to variations in the space environment, changes in vehicle configuration, and operational solar array power manipulation. In particular, rapid variations in ISS potential during solar array operations on time scales of tens of milliseconds can be monitored due to the 128 Hz sample rate of the Floating Potential Probe providing an interesting insight into high voltage solar array interaction with the space plasma environment. Comparing the FPMU data with the ISS operations timeline and solar array data provides a means for correlating some of the more complex and interesting ISS electric potential variations with mission operations. In addition, recent extensions and improvements to the ISS data downlink capabilities have allowed more operating time for the FPMU than ever before. The FPMU was operated for over 200 days in 2013 resulting in the largest data set ever recorded in a single year for the ISS. This presentation will provide examples of a number of the more interesting ISS charging events observed during the 2013 operations including examples of rapid charging events due to solar array power operations, auroral charging events, and other charging behavior related to ISS mission operations.

Exercise Countermeasures on ISS: Summary and Future Directions.

PubMed

Loerch, Linda H

2015-12-01

The first decade of the International Space Station Program (ISS) yielded a wealth of knowledge regarding the health and performance of crewmembers living in microgravity for extended periods of time. The exercise countermeasures hardware suite evolved during the last decade to provide enhanced capabilities that were previously unavailable to support human spaceflight, resulting in attenuation of cardiovascular, muscle, and bone deconditioning. The ability to protect crew and complete mission tasks in the autonomous exploration environment will be a critical component of any decision to proceed with manned exploration initiatives.The next decade of ISS habitation promises to be a period of great scientific utilization that will yield both the tools and technologies required to safely explore the solar system. Leading countermeasure candidates for exploration class missions must be studied methodically on ISS over the next decade to ensure protocols and systems are highly efficient, effective, and validated. Lessons learned from the ISS experience to date are being applied to the future, and international cooperation enables us to maximize this exceptional research laboratory.

ISS Radiation Shielding and Acoustic Simulation Using an Immersive Environment

NASA Technical Reports Server (NTRS)

Verhage, Joshua E.; Sandridge, Chris A.; Qualls, Garry D.; Rizzi, Stephen A.

2002-01-01

The International Space Station Environment Simulator (ISSES) is a virtual reality application that uses high-performance computing, graphics, and audio rendering to simulate the radiation and acoustic environments of the International Space Station (ISS). This CAVE application allows the user to maneuver to different locations inside or outside of the ISS and interactively compute and display the radiation dose at a point. The directional dose data is displayed as a color-mapped sphere that indicates the relative levels of radiation from all directions about the center of the sphere. The noise environment is rendered in real time over headphones or speakers and includes non-spatial background noise, such as air-handling equipment, and spatial sounds associated with specific equipment racks, such as compressors or fans. Changes can be made to equipment rack locations that produce changes in both the radiation shielding and system noise. The ISSES application allows for interactive investigation and collaborative trade studies between radiation shielding and noise for crew safety and comfort.

Gateway Architecture: A Major "Flexible Path" Step to the Moon and Mars After the International Space Station?

NASA Technical Reports Server (NTRS)

Thronson, Harley; Talay, Ted

2010-01-01

With NASA's commitment to the International Space Station (ISS) now all but certain for at least through the coming decade, serious consideration may be given to extended US in-space operations in the 2020s, when presumably the ISS will exceed its sell by date. Indeed, both ESA and Roscosmos, in addition to their unambiguous current commitment to ISS, have published early concept studies for extended post-ISS habitation (e.g., http://www.esa.int/esaHS/index.html, http://www.russianspaceweb.com/opsek.html and references therein). In the US, engineers and scientists have for a decade been working both within and outside NASA to assess one consistent candidate for long-term post-ISS habitation and operations, although interrupted by changing priorities for human space flight, Congressional direction, and constrained budgets. The evolving work of these groups is described here, which may have renewed relevance with the recent completion of a major review of the nation s human space flight program.

The Low Earth Orbit validation of a dynamic and anisotropic trapped radiation model through ISS measurements

NASA Astrophysics Data System (ADS)

Badavi, Francis F.; Nealy, John E.; Wilson, John W.

2011-10-01

The International Space Station (ISS) provides the proving ground for future long duration human activities in space. Ionizing radiation measurements in ISS form the ideal tool for the experimental validation of radiation environmental models, nuclear transport code algorithms and nuclear reaction cross sections. Indeed, prior measurements on the Space Transportation System (STS; Shuttle) have provided vital information impacting both the environmental models and the nuclear transport code development by requiring dynamic models of the Low Earth Orbit (LEO) environment. Previous studies using Computer Aided Design (CAD) models of the evolving ISS configurations with Thermo-Luminescent Detector (TLD) area monitors, demonstrated that computational dosimetry requires environmental models with accurate non-isotropic as well as dynamic behavior, detailed information on rack loading, and an accurate six degree of freedom (DOF) description of ISS trajectory and orientation. It is imperative that we understand ISS exposures dynamically for crew career planning, and insure that the regulatory requirements of keeping exposure as low as reasonably achievable (ALARA) are adequately implemented. This is especially true as ISS nears some form of completion with increasing complexity, resulting in a larger drag coefficient, and requiring operation at higher altitudes with increased exposure rates. In this paper ISS environmental model is configured for 11A (circa mid 2005), and uses non-isotropic and dynamic geomagnetic transmission and trapped proton models. ISS 11A and LEO model validations are important steps in preparation for the design and validation for the next generation manned vehicles. While the described cutoff rigidity, trapped proton and electron formalisms as coded in a package named GEORAD (GEOmagnetic RADiation) and a web interface named OLTARIS (On-line Tool for the Assessment of Radiation in Space) are applicable to the LEO, Medium Earth Orbit (MEO) and Geosynchronous Earth Orbit (GEO) at quiet solar periods, in this report, the validation of the models using available measurements are limited to STS and ISS nominal operational altitudes (300-400 km) range at LEO where the dominant fields within the vehicle are the trapped proton and attenuated Galactic Cosmic Ray (GCR) ions. The described formalism applies to trapped electron at LEO, MEO and GEO as well. Due to the scarcity of available electron measurements, the trapped electron capabilities of the GEORAD are not discussed in this report, but are accessible through OLTARIS web interface. GEORAD and OLTARIS interests are in the study of long term effects (i.e. a meaningful portion of solar cycle). Therefore, GEORAD does not incorporate any short term external field contribution due to solar activity. Finally, we apply these environmental models to selected target points within ISS 6A (circa early 2001), 7A (circa late 2001), and 11A during its passage through the South Atlantic Anomaly (SAA) to assess the validity of the environmental models at ISS altitudes.

Progress Towards a Microgravity CFD Validation Study Using the ISS SPHERES-SLOSH Experiment

NASA Technical Reports Server (NTRS)

Storey, Jedediah M.; Kirk, Daniel; Marsell, Brandon (Editor); Schallhorn, Paul (Editor)

2017-01-01

Understanding, predicting, and controlling fluid slosh dynamics is critical to safety and improving performance of space missions when a significant percentage of the spacecrafts mass is a liquid. Computational fluid dynamics simulations can be used to predict the dynamics of slosh, but these programs require extensive validation. Many CFD programs have been validated by slosh experiments using various fluids in earth gravity, but prior to the ISS SPHERES-Slosh experiment1, little experimental data for long-duration, zero-gravity slosh existed. This paper presents the current status of an ongoing CFD validation study using the ISS SPHERES-Slosh experimental data.

Progress Towards a Microgravity CFD Validation Study Using the ISS SPHERES-SLOSH Experiment

NASA Technical Reports Server (NTRS)

Storey, Jed; Kirk, Daniel (Editor); Marsell, Brandon (Editor); Schallhorn, Paul (Editor)

2017-01-01

Understanding, predicting, and controlling fluid slosh dynamics is critical to safety and improving performance of space missions when a significant percentage of the spacecrafts mass is a liquid. Computational fluid dynamics simulations can be used to predict the dynamics of slosh, but these programs require extensive validation. Many CFD programs have been validated by slosh experiments using various fluids in earth gravity, but prior to the ISS SPHERES-Slosh experiment, little experimental data for long-duration, zero-gravity slosh existed. This paper presents the current status of an ongoing CFD validation study using the ISS SPHERES-Slosh experimental data.

Encapsulating Immunostimulatory CpG Oligonucleotides in Listeriolysin O-Liposomes Promotes a Th1-Type Response and CTL Activity

PubMed Central

Andrews, Chasity D.; Huh, Myung-Sook; Patton, Kathryn; Higgins, Debbie; Van Nest, Gary; Ott, Gary; Lee, Kyung-Dall

2013-01-01

Immunostimulatory sequences (ISS) are short DNA sequences containing unmethylated CpG dimers that have multiple effects on the host immune system, including the ability to stimulate antigen-specific cytotoxic T lymphocytes (CTLs) and drive Th1-type immune responses. Listeriolysin O (LLO)-containing pH-sensitive liposomes have been shown to efficiently deliver macromolecules to the cytosol of APCs and efficiently stimulate CTLs. We hypothesized that encapsulating ISS-oligodeoxyribonucleotides (ODNs) in this delivery system would enhance the cell-mediated immune response and skew Th1-type responses in protein antigen-based vaccination utilizing LLO-liposomes. In vitro studies indicated that co-encapsulation of ISS in LLO-liposomes engendered activation of the NF-κB pathway while maintaining the efficient cytosolic delivery of antigen mediated by the co-encapsulated LLO. Antigen-specific CTL responses monitored by using the model antigen ovalbumin (OVA) in mice were enhanced when mice were immunized with OVA and ISS-ODN-containing LLO-liposomes compared with those immunized with either OVA-containing LLO-liposomes or OVA-ISS conjugates. The enhanced immune responses were of the Th1-type as monitored by the robust OVA-specific IgG2a induction and the OVA CD8 peptide-stimulated IFN-γ secretion. Our study suggests that including ISS-ODN in LLO-containing pH-sensitive liposomes yields a vaccine delivery system that enhances the cell-mediated immune response and skews this response toward the Th1-type. PMID:22376145

Combustion, Complex Fluids, and Fluid Physics Experiments on the ISS

NASA Technical Reports Server (NTRS)

Motil, Brian; Urban, David

2012-01-01

From the very early days of human spaceflight, NASA has been conducting experiments in space to understand the effect of weightlessness on physical and chemically reacting systems. NASA Glenn Research Center (GRC) in Cleveland, Ohio has been at the forefront of this research looking at both fundamental studies in microgravity as well as experiments targeted at reducing the risks to long duration human missions to the moon, Mars, and beyond. In the current International Space Station (ISS) era, we now have an orbiting laboratory that provides the highly desired condition of long-duration microgravity. This allows continuous and interactive research similar to Earth-based laboratories. Because of these capabilities, the ISS is an indispensible laboratory for low gravity research. NASA GRC has been actively involved in developing and operating facilities and experiments on the ISS since the beginning of a permanent human presence on November 2, 2000. As the lead Center for combustion, complex fluids, and fluid physics; GRC has led the successful implementation of the Combustion Integrated Rack (CIR) and the Fluids Integrated Rack (FIR) as well as the continued use of other facilities on the ISS. These facilities have supported combustion experiments in fundamental droplet combustion; fire detection; fire extinguishment; soot phenomena; flame liftoff and stability; and material flammability. The fluids experiments have studied capillary flow; magneto-rheological fluids; colloidal systems; extensional rheology; pool and nucleate boiling phenomena. In this paper, we provide an overview of the experiments conducted on the ISS over the past 12 years.

Cargo Commercial Orbital Transportation Services Environmental Control and Life Support Integration

NASA Technical Reports Server (NTRS)

Duchesne, Stephanie; Thacker, Karen; Williams, Dave

2012-01-01

The International Space Station s (ISS) largest crew and cargo resupply vehicle, the Space Shuttle, retired in 2011. To help augment ISS resupply and return capability, NASA announced a project to promote the development of Commercial Orbital Transportation Services (COTS) for the ISS in January of 2006. By December of 2008, NASA entered into space act agreements with SpaceX and Orbital Sciences Corporation for COTS development and ISS Commercial Resupply Services (CRS). The intent of CRS is to fly multiple resupply missions each year to ISS with SpaceX s Dragon vehicle providing resupply and return capabilities and Orbital Science Corporation s Cygnus vehicle providing resupply capability to ISS. The ISS program launched an integration effort to ensure that these new commercial vehicles met the requirements of the ISS vehicle and ISS program needs. The Environmental Control and Life Support System (ECLSS) requirements cover basic cargo vehicle needs including maintaining atmosphere, providing atmosphere circulation, and fire detection and suppression. The ISS-COTS integration effort brought unique challenges combining NASA s established processes and design knowledge with the commercial companies new initiatives and limited experience with human space flight. This paper will discuss the ISS ECLS COTS integration effort including challenges, successes, and lessons learned.

Commercial Orbital Transportation Cargo Services Environmental Control and Life Support Integration

NASA Technical Reports Server (NTRS)

Duchesne, Stephanie; Williams, Dave; Orozco, Nicole; Philistine, Cynthia

2010-01-01

The International Space Station s (ISS) largest crew and cargo resupply vehicle, the Space Shuttle, will retire in 2011. To help augment ISS resupply and return capability, NASA announced a project to promote the development of Commercial Orbital Transportation Services (COTS) for the ISS in January of 2006. By December of 2008, NASA entered into space act agreements with SpaceX and Orbital Sciences Corporation for COTS development and ISS Commercial Resupply Services (CRS). The intent of CRS is to fly multiple resupply missions each year to ISS with SpaceX s Dragon vehicle providing resupply and return capabilities and Orbital Science Corporation s Cygnus vehicle providing resupply capability to ISS. The ISS program launched an integration effort to ensure that these new commercial vehicles met the requirements of the ISS vehicle and ISS program needs. The Environmental Control and Life Support System (ECLSS) requirements cover basic cargo vehicle needs including maintaining atmosphere, providing atmosphere circulation, and fire detection and suppression. The ISS-COTS integration effort brought unique challenges combining NASA s established processes and design knowledge with the commercial companies new initiatives and limited experience with human space flight. This paper will discuss the ISS ECLS COTS integration effort including challenges, successes, and lessons learned.

The International Space Station (ISS) Education Accomplishments and Opportunities

NASA Technical Reports Server (NTRS)

Alleyne, Camille W.; Blue, Regina; Mayo, Susan

2012-01-01

The International Space Station (ISS) has the unique ability to capture the imaginations of both students and teachers worldwide and thus stands as an invaluable learning platform for the advancement of proficiency in research and development and education. The presence of humans on board ISS for the past ten years has provided a foundation for numerous educational activities aimed at capturing that interest and motivating study in the sciences, technology, engineering and mathematics (STEM) disciplines which will lead to an increase in quality of teachers, advancements in research and development, an increase in the global reputation for intellectual achievement, and an expanded ability to pursue unchartered avenues towards a brighter future. Over 41 million students around the world have participated in ISS-related activities since the year 2000. Projects such as the Amateur Radio on International Space Station (ARISS) and Earth Knowledge Acquired by Middle School Students (EarthKAM), among others, have allowed for global student, teacher, and public access to space through radio contacts with crewmembers and student image acquisition respectively. . With planned ISS operations at least until 2020, projects like the aforementioned and their accompanying educational materials will be available to enable increased STEM literacy around the world. Since the launch of the first ISS element, a wide range of student experiments and educational activities have been performed by each of the international partner agencies: National Aeronautics and Space Administration (NASA), Canadian Space Agency (CSA), European Space Agency (ESA), Japan Aerospace Exploration Agency (JAXA) and Russian Federal Space Agency (Roscosmos). Additionally, a number of non-participating countries, some under commercial agreements, have also participated in Station-related activities. Many of these programs still continue while others are being developed and added to the station crewmembers tasks on a regular basis. These diverse student experiments and programs fall into one of the following categories: student-developed experiments; students performing classroom versions of ISS experiments; students participating in ISS investigator experiments; students participating in ISS engineering education; education demonstrations and cultural activities. This paper summarizes some of the main student experiments and educational activities that have been conducted on the ISS. It also highlights some upcoming projects.

Space Weather Monitoring for ISS Geomagnetic Storm Studies

NASA Technical Reports Server (NTRS)

Minow, Joseph I.; Parker, Neergaard

2013-01-01

The International Space Station (ISS) space environments community utilizes near real time space weather data to support a variety of ISS engineering and science activities. The team has operated the Floating Potential Measurement Unit (FPMU) suite of plasma instruments (two Langmuir probes, a floating potential probe, and a plasma impedance probe) on ISS since 2006 to obtain in-situ measurements of plasma density and temperature along the ISS orbit and variations in ISS frame potential due to electrostatic current collection from the plasma environment (spacecraft charging) and inductive (vxB) effects from the vehicle motion across the Earth s magnetic field. An ongoing effort is to use FPMU for measuring the ionospheric response to geomagnetic storms at ISS altitudes and investigate auroral charging of the vehicle as it passes through regions of precipitating auroral electrons. This work is challenged by restrictions on FPMU operations that limit observation time to less than about a third of a year. As a result, FPMU campaigns ranging in length from a few days to a few weeks are typically scheduled weeks in advance for ISS engineering and payload science activities. In order to capture geomagnetic storm data under these terms, we monitor near real time space weather data from NASA, NOAA, and ESA sources to determine solar wind disturbance arrival times at Earth likely to be geoeffective (including coronal mass ejections and high speed streams associated with coronal holes) and activate the FPMU ahead of the storm onset. Using this technique we have successfully captured FPMU data during a number of geomagnetic storm periods including periods with ISS auroral charging. This presentation will describe the strategies and challenges in capturing FPMU data during geomagnetic storms, the near real time space weather resources utilized for monitoring the space weather environment, and provide examples of auroral charging data obtained during storm operations.

Is the growth outcome of children with idiopathic short stature and isolated growth hormone deficiency following treatment with growth hormone and a luteinizing hormone-releasing hormone agonist superior to that obtained by GH alone?

PubMed

Colmenares, Ana; González, Laura; Gunczler, Peter; Lanes, Roberto

2012-01-01

The aim of this study was to evaluate the effect of combined therapy with growth hormone (GH) and luteinizing hormone-releasing hormone agonist (LHRHa) on the near-final height (NFH) of children with idiopathic short stature (ISS) and growth hormone deficiency (GHD) in early puberty. A retrospective analysis of 20 patients with ISS and 9 patients with GHD treated with combined therapy was undertaken. Twelve children with ISS and ten with GHD, treated with GH alone, served as controls. Patients were matched at baseline for chronological age, bone age, height standard deviation score (SDS), and pubertal development. Patients with ISS or GHD treated with combined therapy improved both their predicted adult height (PAH) at 2 years of therapy (ISS, p < 0.001; GHD, p = 0.03) and their NFH (ISS, p < 0.05; GHD, p = 0.05). Treatment with combined therapy did not generate additional benefits on the PAH after 2 years of therapy (ISS children, an increase of 7.9 +/- 4.9 cm with combined therapy vs. 7.3 +/- 6.0 cm with GH; GHD children, an increase of 6.8 +/- 7.8 cm with combined therapy vs. 5 +/- 5.9 cm with GH). The total height gain SDS was higher in patients treated with GH alone compared with those with combined therapy, but the difference was not significant (ISS children, a gain of 2.4 SDS with GH vs. 0.8 SDS with combined therapy; GHD children, a gain of 1.8 SDS with GH vs. 0.6 SDS with combined therapy). Although 2 years of combined treatment with GH and LHRHa improved the PAH and the NFH of ISS and GHD patients in early puberty, this improvement was not significant compared with that observed in similar subjects treated with GH alone.

Re-Engineering the ISS Payload Operations Control Center During Increased Utilization and Critical Onboard Events

NASA Technical Reports Server (NTRS)

Marsh, Angela L.; Dudley, Stephanie R. B.

2014-01-01

With an increase in the utilization and hours of payload operations being executed onboard the International Space Station (ISS), upgrading the NASA Marshall Space Flight Center (MSFC) Huntsville Operations Support Center (HOSC) ISS Payload Control Area (PCA) was essential to gaining efficiencies and assurance of current and future payload health and science return. PCA houses the Payload Operations Integration Center (POIC) responsible for the execution of all NASA payloads onboard the ISS. POIC Flight Controllers are responsible for the operation of voice, stowage, command, telemetry, video, power, thermal, and environmental control in support of ISS science experiments. The methodologies and execution of the PCA refurbishment were planned and performed within a four month period in order to assure uninterrupted operation of ISS payloads and minimal impacts to payload operations teams. To vacate the PCA, three additional HOSC control rooms were reconfigured to handle ISS realtime operations, Backup Control Center (BCC) to Mission Control in Houston, simulations, and testing functions. This involved coordination and cooperation from teams of ISS operations controllers, multiple engineering and design disciplines, management, and construction companies performing an array of activities simultaneously and in sync delivering a final product with no issues that impacted the schedule. For each console operator discipline, studies of Information Technology (IT) tools and equipment layouts, ergonomics, and lines of sight were performed. Infusing some of the latest IT into the project was an essential goal in ensuring future growth and success of the ISS payload science returns. Engineering evaluations led to a state of the art media wall implementation and more efficient ethernet cabling distribution providing the latest products and the best solution for the POIC. These engineering innovations led to cost savings for the project. Constraints involved in the management of the project included executing over 450 crew-hours of ISS real-time payload operations including a major onboard communications upgrade, SpaceX un-berth, a Soyuz launch, roll-out of ISS live video and interviews from the POIC, annual BCC certification and hurricane season, and ISS simulations and testing. Continuous ISS payload operations were possible during the PCA facility modifications with the reconfiguration of four control rooms and standup of two temporary control areas. Another major restriction to the project was an ongoing facility upgrade that included a NASA Headquarters mandated replacement of all electrical and mechanical systems and replacement of an external generator. These upgrades required a facility power outage during the PCA upgrades. The project also encompassed console layout designs and ordering, amenities selections and ordering, excessing of old equipment, moves, disposal of old IT equipment, camera installations, facility tour re-schedules, and contract justifications. These were just some of the tasks needed for a successful project.

International Space Station Human Behavior and Performance Competency Model: Volume II

NASA Technical Reports Server (NTRS)

Schmidt, Lacey

2008-01-01

This document further defines the behavioral markers identified in the document "Human Behavior and Performance Competency Model" Vol. I. The Human Behavior and Performance (HBP) competencies were recommended as requirements to participate in international long duration missions, and form the basis for determining the HBP training curriculum for long duration crewmembers. This document provides details, examples, knowledge areas, and affective skills to support the use of the HBP competencies in training and evaluation. This document lists examples and details specific to HBP competencies required of astronauts/cosmonauts who participate in ISS expedition and other international long-duration missions. Please note that this model does not encompass all competencies required. While technical competencies are critical for crewmembers, they are beyond the scope of this document. Additionally, the competencies in this model (and subsequent objectives) are not intended to limit the internal activities or training programs of any international partner.

ISS Charging Hazards and Low Earth Orbit Space Weather Effects

NASA Technical Reports Server (NTRS)

Minow, Joseph; Parker, L.; Coffey, V.; Wright K.; Koontz, S.; Edwards, D.

2008-01-01

Current collection by high voltage solar arrays on the International Space Station (ISS) drives the vehicle to negative floating potentials in the low Earth orbit daytime plasma environment. Pre-flight predictions of ISS floating potentials Phi greater than |-100 V| suggested a risk for degradation of dielectric thermal control coatings on surfaces in the U.S. sector due to arcing and an electrical shock hazard to astronauts during extravehicular activity (EVA). However, hazard studies conducted by the ISS program have demonstrated that the thermal control material degradation risk is effectively mitigated during the lifetime of the ISS vehicle by a sufficiently large ion collection area present on the vehicle to balance current collection by the solar arrays. To date, crew risk during EVA has been mitigated by operating one of two plasma contactors during EVA to control the vehicle potential within Phi less than or equal to |-40 V| with a backup process requiring reorientation of the solar arrays into a configuration which places the current collection surfaces into wake. This operation minimizes current collection by the solar arrays should the plasma contactors fail. This paper presents an analysis of F-region electron density and temperature variations at low and midlatitudes generated by space weather events to determine what range of conditions represent charging threats to ISS. We first use historical ionospheric plasma measurements from spacecraft operating at altitudes relevant to the 51.6 degree inclination ISS orbit to provide an extensive database of F-region plasma conditions over a variety of solar cycle conditions. Then, the statistical results from the historical data are compared to more recent in-situ measurements from the Floating Potential Measurement Unit (FPMU) operating on ISS in a campaign mode since its installation in August, 2006.

Mid-Latitude Ionospheric Disturbances Due to Geomagnetic Storms at ISS Altitudes

NASA Technical Reports Server (NTRS)

Minow, Joseph I.; Willis, Emily M.; Neergaard Parker, Linda

2014-01-01

Spacecraft charging of the International Space Station (ISS) is dominated by interaction of the US high voltage solar arrays with the F2-region ionosphere plasma environment. ISS solar array charging is enhanced in a high electron density environment due to the increased thermal electron currents to the edges of the solar cells. High electron temperature environments suppress charging due to formation of barrier potentials on the charged solar cell cover glass that restrict the charging currents to the cell edge [Mandell et al., 2003]. Environments responsible for strong solar array charging are therefore characterized by high electron densities and low electron temperatures. In support of the ISS space environmental effects engineering community, we are working to understand a number of features of solar array charging and to determine how well future charging behavior can be predicted from in-situ plasma density and temperature measurements. One aspect of this work is a need to characterize the magnitude of electron density and temperature variations that occur at ISS orbital altitudes (approximately 400 km) over time scales of days, the latitudes over which significant variations occur, and the time periods over which the disturbances persist once they start. This presentation provides examples of mid-latitude electron density and temperature disturbances at altitudes relevant to ISS using data sets and tools developed for our ISS plasma environment study. "Mid-latitude" is defined as the extra-tropical region between approx. 30 degrees to approx. 60 degrees magnetic latitude sampled by ISS over its 51.6 degree inclination orbit. We focus on geomagnetic storm periods because storms are well known drivers for disturbances in the ionospheric plasma environment.

GNSS-Reflectometry aboard ISS with GEROS: Investigation of atmospheric propagation effects

NASA Astrophysics Data System (ADS)

Zus, F.; Heise, S.; Wickert, J.; Semmling, M.

2015-12-01

GEROS-ISS (GNSS rEflectometry Radio Occultation and Scatterometry) is an ESA mission aboard the International Space Station (ISS). The main mission goals are the determination of the sea surface height and surface winds. Secondary goals are monitoring of land surface parameters and atmosphere sounding using GNSS radio occultation measurements. The international scientific study GARCA (GNSS-Reflectometry Assessment of Requirements and Consolidation of Retrieval Algorithms), funded by ESA, is part of the preparations for GEROS-ISS. Major goals of GARCA are the development of an end2end Simulator for the GEROS-ISS measurements (GEROS-SIM) and the evaluation of the error budget of the GNSS reflectometry measurements. In this presentation we introduce some of the GARCA activities to quantify the influence of the ionized and neutral atmosphere on the altimetric measurements, which is a major error source for GEROS-ISS. At first, we analyse, to which extend the standard linear combination of interferometric paths at different carrier frequencies can be used to correct for the ionospheric propagation effects. Second, we make use of the tangent-linear version of our ray-trace algorithm to propagate the uncertainty of the underlying refractivity profile into the uncertainty of the interferometric path. For comparison the sensitivity of the interferometric path with respect to the sea surface height is computed. Though our calculations are based on a number of simplifying assumptions (the Earth is a sphere, the atmosphere is spherically layered and the ISS and GNSS satellite orbits are circular) some general conclusions can be drawn. In essence, for elevation angles above -5° at the ISS the higher-order ionospheric errors and the uncertaintiy of the inteferometric path due to the uncertainty of the underlying refractivity profile are small enough to distinguish a sea surface height of ± 0.5 m.

Effect of Growth Hormone on Final Height in Children with Idiopathic Short Stature: A UAE, Eastern Region Experience

PubMed Central

Mreish, Shireen; Kaplan, Walid; Chedid, Fares

2017-01-01

Objectives The use of growth hormone (GH) in idiopathic short stature (ISS) has been a subject of debate for the past two decades. We sought to assess the effect of GH on final height (FH) in patients with ISS in our region, which has a high consanguinity rate, and compare it to the effect observed in GH deficient (GHD) patients. Methods We conducted a retrospective chart review from 1 January 2005 to 31 December 2013 for patients with ISS or GHD from the local United Arab Emirates population who received GH treatment and were followed-up regularly in our clinic. The change in height Z-score at 12 months and FH were assessed within each group and between the two groups. Results Twenty-one patients with ISS and 29 patients with GHD were studied. There was a significant change in height Z-score at 12 months and FH in both groups (p < 0.001). The improvement in the ISS group was comparable to the response seen in GHD patients at 12 months (0.5±0.3 standard deviation score (SDS), and 0.5±0.4 SDS, respectively; p = 0.540). The effect on FH was better in ISS group than the GHD group of all etiologies (1.3±0.6 SDS vs. 0.9±0.7 SDS, respectively; p = 0.050), there was no difference between the ISS and the subgroup of idiopathic GHD (1.3±0.5 SDS and 1.2±0.8 SDS, respectively). Conclusions In our local population, GH has a positive effect on the short-term growth and FH of children with ISS to the same extent that has been observed in children with idiopathic GH deficiency. PMID:29218122

Capabilities, Calibration, and Impact of the ISS-RAD Fast Neutron Detector

NASA Technical Reports Server (NTRS)

Leitgab, Martin

2015-01-01

In the current NASA crew radiation health risk assessment framework, estimates for the neutron contributions to crew radiation exposure largely rely on simulated data with sizeable uncertainties due to the lack of experimental measurements inside the ISS. Integrated in the ISS-RAD instrument, the ISS-RAD Fast Neutron Detector (FND) will deploy to the ISS on one of the next cargo supply missions. Together with the ISS-RAD Charged Particle Detector, the FND will perform, for the first time, routine and precise direct neutron measurements inside the ISS between 0.5 and 80 MeV. The measurements will close the NASA Medical Operations Requirement to monitor neutrons inside the ISS and impact crew radiation health risk assessments by reducing uncertainties on the neutron contribution to crew exposure, enabling more efficient mission planning. The presentation will focus on the FND detection mechanism, calibration results and expectations about the FND's interaction with the mixed radiation field inside the ISS.

Application of IRTAM to Support ISS Program Safety

NASA Technical Reports Server (NTRS)

Hartman, William A.; Schmidl, William D.; Mikatarian, Ronald; Koontz, Steven; Galkin, Ivan

2017-01-01

The International Space Station (ISS) orbits near the F-peak of the ionosphere (approximately 400 km altitude). Generally, satellites orbiting at this altitude would have a floating potential (FP) of approximately -1 V due to the electron temperature (Te). However, the ISS has 8 large negatively grounded 160 V solar array wings (SAW) that collect a significant electron current from the ionosphere. This current drives the ISS FP much more negative during insolation and is highly dependent on the electron density (Ne). Also, due to the size of the ISS, magnetic inductance caused by the geomagnetic field produces a delta potential up to 40 V across the truss, possibly producing positive potentials. During Extravehicular Activity (EVA) the negative FP can lead to an arcing hazard when it exceeds -45.5 V, and the positive FP can produce a DC current high enough to stimulate the astronaut's muscles and also cause a hazard. Data collected from the Floating Potential Monitoring Unit (FPMU) have shown that the probability of either of these hazards occurring during times with quiet to moderately disturbed geomagnetic activity is low enough to no longer be considered a risk. However, a study of the ionosphere Ne during severe geomagnetic storm activity has shown that the Ne can be enhanced by a factor of 6 in the ISS orbit. As a result, the ISS Safety Review Panel (SRP) requires that ionospheric conditions be monitored using the FPMU in conjunction with the ISS Plasma Interaction Model (PIM) to determine if a severe geomagnetic storm could result in a plasma environment that could produce a hazard. A 'Real-Time' plasma hazard assessment process was developed to support ISS Program real-time decision making providing constraint relief information for EVAs planning and operations. This process incorporates 'real time' ionospheric conditions, ISS solar arrays' orientation, ISS flight attitude, and where the EVA will be performed on the ISS. This assessment requires real time data that is presently provided by the FPMU including ISS floating potential, along with ionospheric Ne and Te, in order to determine the present environment. Once the present environment conditions are known to be either above, below, or near the current IRI values, the IRI is used to forecast what the environment could become in the event of a severe geomagnetic storm. If the FPMU should fail, the Space Environments team needs another source of data which is utilized to support a short-term forecast for EVAs. The IRI Real-Time Assimilative Mapping (IRTAM) model is an ionospheric model that uses real time measurements from approximately 70 digisondes to produce foF2 and hmF2 global maps in 15 minute cadence. The Boeing Space Environments team has used the IRI coefficients produced in IRTAM to calculate the Ne along the ISS orbital track. The results of the IRTAM model have been compared to FPMU measurements and show excellent agreement (figure 1). IRTAM has been identified as a potential FPMU back-up system will be used as a backup for the FPMU to support the ISS Program following completion of an FPMU/IRTAM validation campaign.

Input-to-state stability of time-varying nonlinear discrete-time systems via indefinite difference Lyapunov functions.

PubMed

Li, Huijuan; Liu, Anping; Zhang, Linli

2018-06-01

In this paper, we propose new sufficient criteria for input-to-state stability (ISS) of time-varying nonlinear discrete-time systems via indefinite difference Lyapunov functions. The proposed sufficient conditions for ISS of system are more relaxed than for ISS with respect to Lyapunov functions with negative definite difference. We prove system is ISS by two methods. The first way is to prove system is ISS by indefinite difference ISS Lyapunov functions. The second method is to prove system is ISS via introducing an auxiliary system and indefinite difference robust Lyapunov functions. The comparison of the sufficient conditions for ISS obtained via the two methods is discussed. The effectiveness of our results is illustrated by three numerical examples. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

[The importance of Injury Severity Score (ISS) in the management of thoracolumbar burst fracture].

PubMed

Rezende, Rodrigo; Avanzi, Osmar

2009-02-01

There are few publications which relate the injury severity score (ISS) to the thoracolumbar burst fractures. For that reason and for the frequency in which they occur, we have evaluated the severity of the trauma in these patients. We have evaluated 190 burst fractures in the spinal cord according to Denis, using the codes of Abbreviated Injury Scales (AIS) for the calculation of the ISS, which uses the three parts of the human body with major severity. These lesions are a squared number and the results are summed up. Among 190 cases evaluated, the median value of the ISS was 13 and the average was 14,4. Males presented a higher ISS than females. The young adult patients presented an average and a median value of the ISS higher than the old patients. The higher the ISS is, the longer the hospitalization period is, except for the patients with the ISS over 35. The fractures in thoracic level show the ISS higher than the rest. The ISS is directly related to surgical treatment and mortality. The ISS values which were found show that a less severe trauma can cause a burst thoracic or lumbar spinal cord fracture. The value of the ISS has not shown correlation to the sex and the fracture level, but it is proportional to the hospitalization period, the surgical treatment and the mortality rate. This result shows a value which is inversely proportional to the age of the patients.

Space Shuttle Program (SSP) Dual Docked Operations (DDO)

NASA Technical Reports Server (NTRS)

Sills, Joel W., Jr.; Bruno, Erica E.

2016-01-01

This document describes the concept definition, studies, and analysis results generated by the Space Shuttle Program (SSP), International Space Station (ISS) Program (ISSP), and Mission Operations Directorate for implementing Dual Docked Operations (DDO) during mated Orbiter/ISS missions. This work was performed over a number of years. Due to the ever increasing visiting vehicle traffic to and from the ISS, it became apparent to both the ISSP and the SSP that there would arise occasions where conflicts between a visiting vehicle docking and/or undocking could overlap with a planned Space Shuttle launch and/or during docked operations. This potential conflict provided the genesis for evaluating risk mitigations to gain maximum flexibility for managing potential visiting vehicle traffic to and from the ISS and to maximize launch and landing opportunities for all visiting vehicles.

Achieving synergy between chemical oxidation and stabilization in a contaminated soil.

PubMed

Srivastava, Vipul J; Hudson, Jeffrey Michael; Cassidy, Daniel P

2016-07-01

Eight in situ solidification/stabilization (ISS) amendments were tested to promote in situ chemical oxidation (ISCO) with activated persulfate (PS) in a contaminated soil. A 3% (by weight) dose of all ISS amendments selected for this study completely activated a 1.5% dose of PS within 3 h by raising temperatures above 30 °C (heat activation) and/or increasing pH above 10.5 (alkaline activation). Heat is released by the reaction of CaO with water, and pH increases because this reaction produces Ca(OH)2. Heat activation is preferred because it generates 2 mol of oxidizing radicals per mole of PS, whereas alkaline activation releases only 1. The relative contribution of heat vs. alkaline activation increased with CaO content of the ISS amendment, which was reflected by enhanced contaminant oxidation with increasing CaO content, and was confirmed by comparing to controls promoting purely heat or alkaline (NaOH) activation. The test soil was contaminated with benzene, toluene, ethylbenzene, and xylenes (BTEX) and polycyclic aromatic hydrocarbons (PAH), particularly naphthalene (NAP). ISS-activated PS oxidized between 47% and 84% of the BTEX & NAP, and between 13% and 33% of the higher molecular weight PAH. ISS-activated PS reduced the leachability of BTEX & NAP by 76%-91% and of the 17 PAH by 83%-96%. Combined ISCO/ISS reduced contaminant leachability far than ISCO or ISS treatments alone, demonstrating the synergy that is possible with combined remedies. Copyright © 2016 Elsevier Ltd. All rights reserved.

SHOX gene defects and selected dysmorphic signs in patients of idiopathic short stature and Léri-Weill dyschondrosteosis.

PubMed

Hirschfeldova, K; Solc, R; Baxova, A; Zapletalova, J; Kebrdlova, V; Gaillyova, R; Prasilova, S; Soukalova, J; Mihalova, R; Lnenicka, P; Florianova, M; Stekrova, J

2012-01-10

The aim of the study was to analyze frequency of SHOX gene defects and selected dysmorphic signs in patients of both idiopathic short stature (ISS) and Léri-Weill dyschondrosteosis (LWD), all derived from the Czech population. Overall, 98 subjects were analyzed in the study. Inclusion criteria were the presence of short stature (-2.0 SD), in combination with at least one of the selected dysmorphic signs for the ISS+ group; and the presence of Madelung deformity, without positive karyotyping for the LWD+ group. Each proband was analyzed by use of P018 MLPA kit, which covers SHOX and its regulatory sequences. Additionally, mutational analysis was done of the coding portions of the SHOX. Both extent and breakpoint localizations in the deletions/duplications found were quite variable. Some PAR1 rearrangements were detected, without obvious phenotypic association. In the ISS+ group, MLPA analysis detected four PAR1 deletions associated with a SHOX gene defect, PAR1 duplication with an ambiguous effect, and two SHOX mutations (13.7%). In the LWD+ group, MLPA analysis detected nine deletions in PAR1 region, with a deleterious effect on SHOX, first reported case of isolated SHOX enhancer duplication, and SHOX mutation (68.8%). In both ISS+ and LWD+ groups were positivity associated with a disproportionately short stature; in the ISS+ group, in combination with muscular hypertrophy. It seems that small PAR1 rearrangements might be quite frequent in the population. Our study suggests disproportionateness, especially in combination with muscular hypertrophy, as relevant indicators of ISS to be the effect of SHOX defect. Copyright © 2011 Elsevier B.V. All rights reserved.

Analyzing an Aging ISS

NASA Technical Reports Server (NTRS)

Scharf, R.

2014-01-01

The ISS External Survey integrates the requirements for photographic and video imagery of the International Space Station (ISS) for the engineering, operations, and science communities. An extensive photographic survey was performed on all Space Shuttle flights to the ISS and continues to be performed daily, though on a level much reduced by the limited available imagery. The acquired video and photo imagery is used for both qualitative and quantitative assessments of external deposition and contamination, surface degradation, dynamic events, and MMOD strikes. Many of these assessments provide important information about ISS surfaces and structural integrity as the ISS ages. The imagery is also used to assess and verify the physical configuration of ISS structure, appendages, and components.

Integrated Project Management: A Case Study in Integrating Cost, Schedule, Technical, and Risk Areas

NASA Technical Reports Server (NTRS)

Smith, Greg

2004-01-01

This viewgraph presentation describes a case study as a model for integrated project management. The ISS Program Office (ISSPO) developed replacement fluid filtration cartridges in house for the International Space Station (ISS). The presentation includes a step-by-step procedure and organizational charts for how the fluid filtration problem was approached.

iss051e029016

NASA Image and Video Library

2017-04-28

iss051e029016 (4/28/2017) --- Crew members on the International Space Station completed a new session of the Genes in Space 2 investigation. Spaceflight causes many changes to the human body, including alterations in DNA and a weakened immune system. This study uses a new technology to study DNA in space to try and safeguard crew health. Credits: NASA

iss051e044502

NASA Image and Video Library

2017-05-17

iss051e044502 (5/17/2017) --- Crew members on the International Space Station completed a new session of the Genes in Space 2 investigation. Spaceflight causes many changes to the human body, including alterations in DNA and a weakened immune system. This study uses a new technology to study DNA in space to try and safeguard crew health. Credits: NASA

iss051e044497

NASA Image and Video Library

2017-05-17

iss051e044497 (5/17/2017) --- Crew members on the International Space Station completed a new session of the Genes in Space 2 investigation. Spaceflight causes many changes to the human body, including alterations in DNA and a weakened immune system. This study uses a new technology to study DNA in space to try and safeguard crew health. Credits: NASA

Benchmark Studies of the Effectiveness of Structural and Internal Materials as Radiation Shielding for the International Space Station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, J.; Zeitlin, C.; Cucinotta, F.A.

2002-05-09

Accelerator-based measurements and model calculations have been used to study the heavy ion radiation transport properties of materials in use on the International Space Station (ISS). Samples of the ISS aluminum outer hull were augmented with various configurations of internal wall material and polyethylene. The materials were bombarded with high energy Fe ions characteristic of a significant part of the Galactic Cosmic Ray (GCR) heavy ion spectrum. Transmitted primary ions and charged fragments produced in nuclear collisions in the materials were measured near the beam axis, and a model was used to extrapolate from the data to lower beam energiesmore » and to a lighter ion. For the materials and ions studied, at incident particle energies from 1037 MeV/nucleon down to at least 600 MeV/nucleon, nuclear fragmentation reduces the average dose and dose equivalent per incident ion. At energies below 400 MeV/nucleon, the calculation predicts that as material is added, increased ionization energy loss produces increases in some dosimetric quantities. These limited results suggest that the addition of modest amounts of polyethylene or similar material to the interior of the ISS will reduce the dose to ISS crews from space radiation; however the radiation transport properties of ISS materials should be evaluated with a realistic space radiation field.« less

Benchmark studies of the effectiveness of structural and internal materials as radiation shielding for the international space station.

PubMed

Miller, J; Zeitlin, C; Cucinotta, F A; Heilbronn, L; Stephens, D; Wilson, J W

2003-03-01

Accelerator-based measurements and model calculations have been used to study the heavy-ion radiation transport properties of materials in use on the International Space Station (ISS). Samples of the ISS aluminum outer hull were augmented with various configurations of internal wall material and polyethylene. The materials were bombarded with high-energy iron ions characteristic of a significant part of the galactic cosmic-ray (GCR) heavy-ion spectrum. Transmitted primary ions and charged fragments produced in nuclear collisions in the materials were measured near the beam axis, and a model was used to extrapolate from the data to lower beam energies and to a lighter ion. For the materials and ions studied, at incident particle energies from 1037 MeV/nucleon down to at least 600 MeV/nucleon, nuclear fragmentation reduces the average dose and dose equivalent per incident ion. At energies below 400 MeV/nucleon, the calculation predicts that as material is added, increased ionization energy loss produces increases in some dosimetric quantities. These limited results suggest that the addition of modest amounts of polyethylene or similar material to the interior of the ISS will reduce the dose to ISS crews from space radiation; however, the radiation transport properties of ISS materials should be evaluated with a realistic space radiation field. Copyright 2003 by Radiation Research Society

iss047e134605

NASA Image and Video Library

2016-05-30

ISS047e134605 (05/30/2016) --- ESA (European Space Agency) astronaut Tim Peake uses hardware for the Vascular Echo experiment. As humans get older on Earth, arteries stiffen and this causes an increase in blood pressure (hypertension) and elevates the risk for cardiovascular disease. Recently, it has been observed that some crew members returning from the International Space Station (ISS) have much stiffer arteries than when they went into space. The results from studying these changes could provide insight into potential countermeasures to help maintain crew member health, and quality of life for everyone.

International Space Station as a Base Camp for Exploration Beyond Low Earth Orbit

NASA Technical Reports Server (NTRS)

Raftery, Michael; Hoffman, Jeffrey

2011-01-01

The idea for using the International Space Station (ISS) as platform for exploration has matured in the past year and the concept continues to gain momentum. ISS provides a robust infrastructure which can be used to test systems and capabilities needed for missions to the Moon, Mars, asteroids and other potential destinations. International cooperation is a critical enabler and ISS has already demonstrated successful management of a large multi-national technical endeavor. Systems and resources needed for expeditions can be aggregated and thoroughly tested at ISS before departure thus providing wide operational flexibility and the best assurance of mission success. A small part of ISS called an Exploration Platform (ISS-EP) can be placed at Earth-Moon Libration point 1 (EML1) providing immediate benefits and flexibility for future exploration missions. We will show how ISS and the ISS-EP can be used to reduce risk and improve the operational flexibility for missions beyond low earth orbit. Life support systems and other technology developed for ISS can be evolved and adapted to the ISS-EP and other exploration spacecraft. New technology, such as electric propulsion and advanced life support systems can be tested and proven at ISS as part of an incremental development program. Commercial companies who are introducing transportation and other services will benefit with opportunities to contribute to the mission since ISS will serve as a focal point for the commercialization of low earth orbit services. Finally, we will show how use of ISS provides immediate benefits to the scientific community because its capabilities are available today and certain critical aspects of exploration missions can be simulated.

Productivity of Mizuna Cultivated in the Space Greenhouse Onboard the Russian Module of the Iss

NASA Astrophysics Data System (ADS)

Levinskikh, Margarita; Sychev, Vladimir; Podolsky, Igor; Bingham, Gail; Moukhamedieva, Lana

As stipulated by the science program of research into the processes of growth, development, metabolism and reproduction of higher plants in microgravity in view of their potential use in advanced life support systems, five experiments on Mizuna plants (Brassica rapa var. nipponisica) were performed using the Lada space greenhouse onboard the ISS Russian Module (RM) during Expeditions ISS-5, 17 and 20-22. One of the goals of the experiments was to evaluate the productivity of Mizuna plants grown at different levels of ISS RM air contamination. Mizuna plants were cultivated for 31 - 36 days when exposed to continuous illumination. The root growing medium was made of Turface enriched with a controlled release fertilizer Osmocote. In the course of the flight experiments major parameters of plant cultivation, total level of ISS RM air contamination and plant microbiological status were measured. The grown plants were returned to Earth as fresh or frozen samples. After the three last vegetation cycles the plants were harvested, packed and frozen at -80 0C in the MELFI freezer on the ISS U.S. Module and later returned to Earth onboard Space Shuttle. It was found that the productivity and morphometric (e.g., plant height and mass, number of leaves) parameters of the plants grown in space did not differ from those seen in ground controls. The T coefficient, which represents the total contamination level of ISS air), was 4 (ISS-5), 22 (ISS-17), 55 (ISS-20), 22 (ISS-21) and 28 (ISS-22) versus the norm of no more than 5. In summary, a significant increase in the total contamination level of the ISS RM air did not reduce the productivity of the leaf vegetable plant used in the flight experiments.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e190769 - iss042e191096). Shows Earth views. Solar Array Wing (SAW) in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e330173 - iss042e331530). Shows Earth views. Solar Array Wing (SAW) in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e238532 - iss042e239150). Shows Earth views. Solar Array Wing (SAW) in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e177446 - iss042e178444 ). Shows Earth views. Solar Array Wing (SAW) in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e110489 - iss042e111902). Shows Earth views. Solar Array Wing (SAW) in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e212874 - iss042e213080). Shows Earth views. Solar Array Wing (SAW) in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e285752 - iss042e286830). Shows Earth views. Solar Array Wing (SAW) in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e116561 - iss042e117265). Shows Earth views. Solar Array Wing (SAW) in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (iss042e071550 - iss042e072050). Shows Earth views over Africa, Sinai, Saudi Arabia, Jordan and Israel.

Comparison of response to 2-years' growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observational studies.

PubMed

Lee, Peter A; Sävendahl, Lars; Oliver, Isabelle; Tauber, Maithé; Blankenstein, Oliver; Ross, Judith; Snajderova, Marta; Rakov, Viatcheslav; Pedersen, Birgitte Tønnes; Christesen, Henrik Thybo

2012-07-12

Few studies have compared the response to growth hormone (GH) treatment between indications such as isolated growth hormone deficiency (IGHD), born small for gestational age (SGA), idiopathic short stature (ISS), and multiple pituitary hormone deficiency (MPHD). The aim of this analysis of data, collected from two large ongoing observational outcome studies, was to evaluate growth and insulin-like growth factor-I (IGF-I) response data for children of short stature with IGHD, MPHD, SGA, or ISS following two years of treatment with the recombinant GH product Norditropin® (Novo Nordisk A/S, Bagsværd, Denmark). Analysis of auxologic data from two ongoing prospective observational studies, NordiNet® International Outcomes Study (NordiNet® IOS) and NovoNet®/American Norditropin® Web-enabled Research (ANSWER) Program®. 4,582 children aged <18 years were included: IGHD, n = 3,298; SGA, n = 678; ISS, n = 334; and MPHD, n = 272. After two years' GH treatment, change in height standard deviation score (SDS) was +1.03 in SGA and +0.84 in ISS vs. +0.97 in IGHD (p = 0.047; p < 0.001 vs. IGHD, respectively). Height gain was comparable between IGHD and MPHD. In pre-pubertal children vs. total population, height SDS change after two years was: IGHD, +1.24 vs. +0.97; SGA, +1.17 vs. +1.03; ISS, +1.04 vs. +0.84; and MPHD, +1.16 vs. +0.99 (all p < 0.001). After two years' GH treatment, change in height SDS was greater in SGA and less in ISS, compared with IGHD; the discrepancy in responses may be due to the disease nature or confounders (i.e. age). Height SDS increase was greatest in pre-pubertal children, supporting early treatment initiation to optimize growth outcomes.

Observations of Transient ISS Floating Potential Variations During High Voltage Solar Array Operations

NASA Technical Reports Server (NTRS)

Willis, Emily M.; Minow, Joseph I.; Parker, Linda N.; Pour, Maria Z. A.; Swenson, Charles; Nishikawa, Ken-ichi; Krause, Linda Habash

2016-01-01

The International Space Station (ISS) continues to be a world-class space research laboratory after over 15 years of operations, and it has proven to be a fantastic resource for observing spacecraft floating potential variations related to high voltage solar array operations in Low Earth Orbit (LEO). Measurements of the ionospheric electron density and temperature along the ISS orbit and variations in the ISS floating potential are obtained from the Floating Potential Measurement Unit (FPMU). In particular, rapid variations in ISS floating potential during solar array operations on time scales of tens of milliseconds can be recorded due to the 128 Hz sample rate of the Floating Potential Probe (FPP) pro- viding interesting insight into high voltage solar array interaction with the space plasma environment. Comparing the FPMU data with the ISS operations timeline and solar array data provides a means for correlating some of the more complex and interesting transient floating potential variations with mission operations. These complex variations are not reproduced by current models and require further study to understand the underlying physical processes. In this paper we present some of the floating potential transients observed over the past few years along with the relevant space environment parameters and solar array operations data.

Ghrelin plasma levels in patients with idiopathic short stature.

PubMed

Iñiguez, Germán; Román, Rossana; Youlton, Ronald; Cassorla, Fernando; Mericq, Verónica

2011-02-01

Novel molecular insights have suggested that ghrelin may be involved in the pathogenesis of some forms of short stature. Recently, growth hormone secretagogue receptor (GHSR) mutations that segregate with short stature have been reported. To study plasma ghrelin levels in prepubertal patients with idiopathic short stature (ISS). Fasting total plasma ghrelin levels (radioimmunoassay) in 41 prepubertal patients with ISS (18 females, age 7.9 ± 0.5 years) compared with 42 age- and sex-matched controls (27 females, age 8.0 ± 0.3 years) with normal height. In a subset of 28 patients, the ghrelin receptor was sequenced. ISS patients exhibited a higher level of ghrelin (1,458 ± 137 vs. 935 ± 55 pg/ml, p < 0.01) and similar IGF-I levels (-0.66 ± 1.29 vs. -0.32 ± 0.78 SDS) compared to controls. Ten patients with ISS had ghrelin levels greater than +2 SDS compared to controls. These patients did not differ in height, BMI or IGF-I SDS compared to ISS patients with ghrelin levels within the normal range. Molecular analysis of GHSR did not show any mutations, but showed some polymorphisms. These results suggest that in ISS patients, short stature does not appear to be frequently caused by abnormalities in ghrelin signaling. Copyright © 2010 S. Karger AG, Basel.

Integrated Atmosphere Resource Recovery and Environmental Monitoring Technology Demonstration for Deep Space Exploration

NASA Technical Reports Server (NTRS)

Perry, Jay L.; Abney, Morgan B.; Knox, James C.; Parrish, Keith J.; Roman, Monserrate C.; Jan, Darrell L.

2012-01-01

Exploring the frontiers of deep space continues to be defined by the technological challenges presented by safely transporting a crew to and from destinations of scientific interest. Living and working on that frontier requires highly reliable and efficient life support systems that employ robust, proven process technologies. The International Space Station (ISS), including its environmental control and life support (ECLS) system, is the platform from which humanity's deep space exploration missions begin. The ISS ECLS system Atmosphere Revitalization (AR) subsystem and environmental monitoring (EM) technical architecture aboard the ISS is evaluated as the starting basis for a developmental effort being conducted by the National Aeronautics and Space Administration (NASA) via the Advanced Exploration Systems (AES) Atmosphere Resource Recovery and Environmental Monitoring (ARREM) Project.. An evolutionary approach is employed by the ARREM project to address the strengths and weaknesses of the ISS AR subsystem and EM equipment, core technologies, and operational approaches to reduce developmental risk, improve functional reliability, and lower lifecycle costs of an ISS-derived subsystem architecture suitable for use for crewed deep space exploration missions. The most promising technical approaches to an ISS-derived subsystem design architecture that incorporates promising core process technology upgrades will be matured through a series of integrated tests and architectural trade studies encompassing expected exploration mission requirements and constraints.

iss038e055240

NASA Image and Video Library

2014-02-24

ISS038-E-055240 (24 Feb. 2014) --- In the International Space Station's Destiny laboratory, NASA astronaut Mike Hopkins, Expedition 38 flight engineer, sets up the Advanced Colloids Experiment (ACE) housed in the Light Microscopy Module (LMM) inside the Fluids Integrated Rack. ACE studies microscopic particles suspended in a liquid.

ISS Training Best Practices and Lessons Learned

NASA Technical Reports Server (NTRS)

Barshi, Immanuel; Dempsey, Donna L.

2017-01-01

Training our crew members for long duration exploration-class missions (LDEM) will have to be qualitatively and quantitatively different from current training practices. However, there is much to be learned from the extensive experience NASA has gained in training crew members for missions on board the International Space Station (ISS). Furthermore, the operational experience on board the ISS provides valuable feedback concerning training effectiveness. Keeping in mind the vast differences between current ISS crew training and training for LDEM, the needs of future crew members, and the demands of future missions, this ongoing study seeks to document current training practices and lessons learned. The goal of the study is to provide input to the design of future crew training that takes as much advantage as possible of what has already been learned and avoids as much as possible past inefficiencies. Results from this study will be presented upon its completion. By researching established training principles, examining future needs, and by using current practices in spaceflight training as test beds, this research project is mitigating program risks and generating templates and requirements to meet future training needs.

ISS Training Best Practices and Lessons Learned

NASA Technical Reports Server (NTRS)

Dempsey, Donna L.; Barshi, Immanuel

2018-01-01

Training our crew members for long-duration Deep Space Transport (DST) missions will have to be qualitatively and quantitatively different from current training practices. However, there is much to be learned from the extensive experience NASA has gained in training crew members for missions on board the International Space Station (ISS). Furthermore, the operational experience on board the ISS provides valuable feedback concerning training effectiveness. Keeping in mind the vast differences between current ISS crew training and training for DST missions, the needs of future crew members, and the demands of future missions, this ongoing study seeks to document current training practices and lessons learned. The goal of the study is to provide input to the design of future crew training that takes as much advantage as possible of what has already been learned and avoids as much as possible past inefficiencies. Results from this study will be presented upon its completion. By researching established training principles, examining future needs, and by using current practices in spaceflight training as test beds, this research project is mitigating program risks and generating templates and requirements to meet future training needs.

Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice

PubMed Central

Killoran, Kristin E.; Miller, Amber D.; Uray, Karen S.; Weisbrodt, Norman W.; Pautler, Robia G.; Goyert, Sanna M.; van Rooijen, Nico

2014-01-01

Intestinal intussusception (ISS) commonly causes intestinal obstruction in children. One mechanism that has been proposed to cause ISS is inflammation-induced alteration of intestinal motility. We investigated whether innate inflammatory factors or altered motility is required for induction of ISS by LPS. We compared rates of ISS among BALB/c and C57BL/6 mice, mice lacking lymphocytes or depleted of phagocytes, or mice with defects in the Toll-like receptor 4 (TLR4) signaling pathway following administration of LPS or the Ca2+ analog MnCl2. At 6 or 2 h after administration of LPS or MnCl2, respectively, mice underwent image analysis to assess intestinal contraction rate or laparotomy to identify ISS. LPS-induced ISS (LPS-ISS) was observed in BALB/c mice, but not in C57BL/6 mice or any BALB/c mice with disruptions of TLR4 signaling. LPS-induced serum TNF-α, IL-6, and nitric oxide (NO) and intestinal NO levels were similar in BALB/c and C57BL/6 mice. The rate of LPS-ISS was significantly reduced in phagocyte-depleted, but not lymphocyte-deficient, mice. Intestinal contraction rates were reduced in LPS-ISS-susceptible BALB/c mice, but not in LPS-ISS-resistant C57BL/6 or TLR4 mutant mice, suggesting a role for reduced intestinal contraction rate in LPS-ISS susceptibility. This was tested with MnCl2, a Ca2+ antagonist that reduced intestinal contraction rates and induced ISS, irrespective of mouse strain. Therefore, LPS-ISS is initiated by innate immune signaling that requires TLR4 and phagocytes but may be independent of TNF-α, IL-6, and NO levels. Furthermore, alteration of intestinal motility, specifically, reduced intestinal contraction rate, is a key factor in the development of ISS. PMID:24407593

ISS And Space Environment Interactions Without Operating Plasma Contactor

NASA Technical Reports Server (NTRS)

Carruth, M. R., Jr.; Ferguson, Dale; Suggs,Rob; McCollum, Matt

2001-01-01

The International Space Station (ISS) will be the largest, highest power spacecraft placed in orbit. Because of this the design of the electrical power system diverged markedly from previous systems. The solar arrays will operate at 160 V and the power distribution voltage will be 120 V. The structure is grounded to the negative side of the solar arrays so under the right circumstances it is possible to drive the ISS potential very negative. A plasma contactor has been added to the ISS to provide control of the ISS structure potential relative to the ambient plasma. The ISS requirement is that the ISS structure not be greater than 40 V positive or negative of local plasma. What are the ramifications of operating large structures with such high voltage power systems? The application of a plasma contactor on ISS controls the potential between the structure and the local plasma, preventing degrading effects. It is conceivable that there can be situations where the plasma contactor might be non-functional. This might be due to lack of power, the need to turn it off during some of the build-up sequences, the loss of functionality for both plasma contactors before a replacement can be installed, similar circumstances. A study was undertaken to understand how important it is to have the contactor functioning and how long it might be off before unacceptable degradation to ISS could occur. The details of interaction effects on spacecraft have not been addressed until driven by design. This was true for ISS. If the structure is allowed to float highly negative impinging ions can sputter exposed conductors which can degrade the primary surface and also generate contamination due to the sputtered material. Arcing has been known to occur on solar arrays that float negative of the ambient plasma. This can also generate electromagnetic interference and voltage transients. Much of the ISS structure and pressure module surfaces exposed to space is anodized aluminum. The anodization thickness is very thin to provide the required solar absorptance and emittance. For conditions where ISS structure can charge negative a large percentage of the array voltage, the dielectric strength of this layer is low, and dielectric breakdown (arcing) can occur. The energy stored capacitively in the structure can be delivered to the arc. The mechanisms by which this energy is delivered and how much of the energy is available hasn't been fully quantified. Questions have been raised regarding the possibility of whether a sustained arc might result due to current collected by the solar arrays from local plasma. It was postulated that even if dielectric breakdown didn't occur, impacts due to micrometeoroids and space debris could penetrate thin layers of dielectric on ISS and initiate an arc due to the coupling provided by the dense local plasma produced by the impact. This was proven in experiments conducted jointly by MSFC and Auburn University. A target chamber with a simulated ionospheric plasma and a biased, anodized aluminum plate and a 1-microfarad capacitor was used. The plate was then impacted by 75-micron particles accelerated to orbital velocity. Arc discharges were sustained for higher voltages but a threshold appears below which no discharge was initiated. Most items without an exposed power system will float electrically near the local plasma potential. This is true of the Space Shuttle, an Astronaut on EVA, and similar items. The structure of ISS might be at a large negative voltage. Therefore, capacitively stored energy can be transferred during docking, installing external boxes and equipment and Astronaut contact with ISS structure. The circumstances of when this can happen and the resulting effects are evaluated in this study. Also, a crewmember on EVA might be in the vicinity of an arc. All safety aspects of such an encounter including charging, molten particles from the arc site and EMI have been evaluated. This paper will report on the total results of this study focussed on the 4A configuration, scheduled to be complete in November, 2000. Interactions such as arcing, debris induced arcs, sustained arcs, sputtering, contamination from sputtering and arcing, docking interactions and Astronaut safety issues will all be addressed.

ISS Utilization Potential for 2011-2020 and Beyond

NASA Astrophysics Data System (ADS)

Askew, R.; Chabrow, J.; Nakagawa, R.

The US concept for a permanent human presence in space as directed by President Ronald Reagan in 1984 was called Space Station Freedom. This was the precursor to the International Space Station (ISS) that now orbits the earth. The first element of the ISS, Zarya, was launched November 20, 1998. The launch of STS-133 provides the final component of the assembly, the Multi-Purpose Logistics Module (MPLM). During the assembly the ISS was utilized to the extent possible for the conduct of scientific research and technology development, and for the development of enhancements to the ISS capabilities. These activities have resulted in a significant database of lessons learned regarding operations, both of the ISS platform as well as in the conduct of research. For the coming decade utilization of the ISS will be impacted by how these lessons learned are used to improve operations. Access to the ISS and to its capabilities will determine the types of projects that can use the ISS. Perhaps the most critical limitation is the funds that must be invested by potential users of the ISS. This paper examines the elements that have been identified as impediments to utilization of the ISS by both basic researchers and by the private sector over the past decade and provides an assessment of which of these are likely to be satisfactorily altered and on what time scale.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e260338 - iss042e261334). Shows night time Earth views taken from the Cupola module.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

s time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e207712 - iss042e209132 ). Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e203119 - iss042e203971). Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e334978 - iss042e335976). Shows Earth views. Solar Array Wing (SAW) comes into view.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e324104 - iss042e325631). Shows Earth views. Soyuz and Progress spacecrafts come into view.

Exome sequencing and arrayCGH detection of gene sequence and copy number variation between ILS and ISS mouse strains.

PubMed

Dumas, Laura; Dickens, C Michael; Anderson, Nathan; Davis, Jonathan; Bennett, Beth; Radcliffe, Richard A; Sikela, James M

2014-06-01

It has been well documented that genetic factors can influence predisposition to develop alcoholism. While the underlying genomic changes may be of several types, two of the most common and disease associated are copy number variations (CNVs) and sequence alterations of protein coding regions. The goal of this study was to identify CNVs and single-nucleotide polymorphisms that occur in gene coding regions that may play a role in influencing the risk of an individual developing alcoholism. Toward this end, two mouse strains were used that have been selectively bred based on their differential sensitivity to alcohol: the Inbred long sleep (ILS) and Inbred short sleep (ISS) mouse strains. Differences in initial response to alcohol have been linked to risk for alcoholism, and the ILS/ISS strains are used to investigate the genetics of initial sensitivity to alcohol. Array comparative genomic hybridization (arrayCGH) and exome sequencing were conducted to identify CNVs and gene coding sequence differences, respectively, between ILS and ISS mice. Mouse arrayCGH was performed using catalog Agilent 1 × 244 k mouse arrays. Subsequently, exome sequencing was carried out using an Illumina HiSeq 2000 instrument. ArrayCGH detected 74 CNVs that were strain-specific (38 ILS/36 ISS), including several ISS-specific deletions that contained genes implicated in brain function and neurotransmitter release. Among several interesting coding variations detected by exome sequencing was the gain of a premature stop codon in the alpha-amylase 2B (AMY2B) gene specifically in the ILS strain. In total, exome sequencing detected 2,597 and 1,768 strain-specific exonic gene variants in the ILS and ISS mice, respectively. This study represents the most comprehensive and detailed genomic comparison of ILS and ISS mouse strains to date. The two complementary genome-wide approaches identified strain-specific CNVs and gene coding sequence variations that should provide strong candidates to contribute to the alcohol-related phenotypic differences associated with these strains.

Trauma with Injury Severity Score of 75: Are These Unsurvivable Injuries?

PubMed Central

Peng, Jin; Wheeler, Krista; Shi, Junxin; Groner, Jonathan Ira; Haley, Kathryn Jo; Xiang, Huiyun

2015-01-01

Trauma patients with an ISS=75 have been deliberately excluded from some trauma studies because they were assumed to have "unsurvivable injuries." This study aimed to assess the true mortality among patients with an ISS=75, and to examine the characteristics and primary diagnoses of these patients. Retrospective review of the 2006-2010 U.S. Nationwide Emergency Department Sample (NEDS) generated 2,815 patients with an ISS=75 for analysis, representing an estimated 13,569 patients in the country. Dispositions from the emergency department and hospital for these patients were tabulated by trauma center level. Survivors and non-survivors were compared using Pearson's chi-square test. Primary diagnosis codes of these patients were tabulated by mortality status. Overall, about 48.6% of patients with an ISS=75 were discharged alive, 25.8% died and 25.6% had unknown mortality status. The mortality risks of these patients did not vary significantly across different levels of trauma centers (15.6% vs. 13.0%, P = 0.16). Non-survivors were more likely than survivors to: be male (81.2% vs. 74.4%, P < 0.0001), be over 65 years (20.3% vs. 10.2%, P < 0.0001), be uninsured (33.8% vs. 19.1%), have at least one chronic condition (58.0% vs. 43.7%, P <0.0001), sustain life-threatening injuries (79.2% vs. 49.4%, P<0.0001), sustain penetrating injuries (42.0% vs. 25.9%, P<0.0001), and have injuries caused by motor vehicle crashes (32.9% vs. 21.1%, P<0.0001) or firearms (21.9% vs. 4.4%, P<0.0001). The most frequent diagnosis code was 862.8 (injury to multiple and unspecified intrathoracic organs, without mention of open wound into cavity). Our results revealed that at least half of patients with an ISS=75 survived, demonstrating that the rationale for excluding patients with an ISS=75 from analysis is not always justified. To avoid bias and inaccurate results, trauma researchers should examine the mortality status of patients with an ISS=75 before exclusion, and explicitly describe their method of generating ISS scores. PMID:26230931

Use of the International Space Station as an Exercise Physiology Lab

NASA Technical Reports Server (NTRS)

Ploutz-Snyder, Lori

2013-01-01

The International Space Station (ISS) is now in its prime utilization phase with great opportunity to use the ISS as a lab. With respect to exercise physiology there is considerable research opportunity. Crew members exercise for up to 2 hours per day using a cycle ergometer, treadmill, and advanced resistive exercise device (ARED). There are several ongoing exercise research studies by NASA, ESA and CSA. These include studies related to evaluation of new exercise prescriptions (SPRINT), evaluation of aerobic capacity (VO2max), biomechanics (Treadmill Kinematics), energy expenditure during spaceflight (Energy), evaluation of cartilage (Cartilage), and evaluation of cardiovascular health (Vascular). Examples of how ISS is used for exercise physiology research will be presented.

Comparison of Analytical and Numerical Performance Predictions for an International Space Station Node 3 Internal Active Thermal Control System Regenerative Heat Exchanger

NASA Technical Reports Server (NTRS)

Wise, Stephen A.; Holt, James M.

2002-01-01

The complexity of International Space Station (ISS) systems modeling often necessitates the concurrence of various dissimilar, parallel analysis techniques to validate modeling. This was the case with a feasibility and performance study of the ISS Node 3 Regenerative Heat Exchanger (RHX). A thermo-hydraulic network model was created and analyzed in SINDA/FLUINT. A less complex, closed form solution of the systems dynamics was created using an Excel Spreadsheet. The purpose of this paper is to provide a brief description of the modeling processes utilized, the results and benefits of each to the ISS Node 3 RHX study.

Comparison of Analytical and Numerical Performance Predictions for a Regenerative Heat Exchanger in the International Space Station Node 3 Internal Active Thermal Control System

NASA Technical Reports Server (NTRS)

Wise, Stephen A.; Holt, James M.; Turner, Larry D. (Technical Monitor)

2001-01-01

The complexity of International Space Station (ISS) systems modeling often necessitates the concurrence of various dissimilar, parallel analysis techniques to validate modeling. This was the case with a feasibility and performance study of the ISS Node 3 Regenerative Heat Exchanger (RHX). A thermo-hydraulic network model was created and analyzed in SINDA/FLUINT. A less complex, closed form solution of the system dynamics was created using Excel. The purpose of this paper is to provide a brief description of the modeling processes utilized, the results and benefits of each to the ISS Node 3 RHX study.

Evaluating the Medical Kit System for the International Space Station(ISS) - A Paradigm Revisited

NASA Technical Reports Server (NTRS)

Hailey, Melinda J.; Urbina, Michelle C.; Hughlett, Jessica L.; Gilmore, Stevan; Locke, James; Reyna, Baraquiel; Smith, Gwyn E.

2010-01-01

Medical capabilities aboard the International Space Station (ISS) have been packaged to help astronaut crew medical officers (CMO) mitigate both urgent and non-urgent medical issues during their 6-month expeditions. Two ISS crewmembers are designated as CMOs for each 3-crewmember mission and are typically not physicians. In addition, the ISS may have communication gaps of up to 45 minutes during each orbit, necessitating medical equipment that can be reliably operated autonomously during flight. The retirement of the space shuttle combined with ten years of manned ISS expeditions led the Space Medicine Division at the NASA Johnson Space Center to reassess the current ISS Medical Kit System. This reassessment led to the system being streamlined to meet future logistical considerations with current Russian space vehicles and future NASA/commercial space vehicle systems. Methods The JSC Space Medicine Division coordinated the development of requirements, fabrication of prototypes, and conducted usability testing for the new ISS Medical Kit System in concert with implementing updated versions of the ISS Medical Check List and associated in-flight software applications. The teams constructed a medical kit system with the flexibility for use on the ISS, and resupply on the Russian Progress space vehicle and future NASA/commercial space vehicles. Results Prototype systems were developed, reviewed, and tested for implementation. Completion of Preliminary and Critical Design Reviews resulted in a streamlined ISS Medical Kit System that is being used for training by ISS crews starting with Expedition 27 (June 2011). Conclusions The team will present the process for designing, developing, , implementing, and training with this new ISS Medical Kit System.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e211498 - iss042e212135). Shows Earth views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e162807 - iss042e163936). Shows Earth views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e210380 - iss042e211441). Shows Earth views. Solar Array Wing (SAW) in and out of view.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e193144 - iss042e194102). Shows Earth views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e209133 - iss042e210379). Shows Earth views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e215401 -iss042e215812). Shows Earth views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e290689 - iss042e291289). Shows Earth views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e249923 - iss042e250759). Shows Earth views. Space Station Remote Manipulator system (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e170341 - iss042e171462). Shows Earth views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e244330 - iss042e245101). Shows Earth views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

Identification, cloning and sequencing of Escherichia coli strain chi1378 (O78:K80) iss gene isolated from poultry colibacillosis in Iran.

PubMed

Derakhshandeh, A; Zahraei Salehi, T; Tadjbakhsh, H; Karimi, V

2009-09-01

To identify, clone and sequence the iss (increased serum survival) gene from E. coli strain chi1378 isolated from Iranian poultry and to predict its protein product, Iss. The iss gene from E. coli strain chi1378 was amplified and cloned into the pTZ57R/T vector and sequenced. From the DNA sequence, the Iss predictive protein was evaluated using bioinformatics. Iss from strain chi1378 had 100% identity with other E. coli serotypes and isolates from different origins and also 98% identity with E. coli O157:H7 Iss protein. Phylogenetic analysis showed no significant different phylogenic groups among E. coli strains. The strong association of predicted Iss protein among different E. coli strains suggests that it could be a good antigen to control and detect avian pathogenic E. coli (APEC). Because the exact pathogenesis and the role of virulence factors are unknown, the Iss protein could be used as a target for vaccination in the future, but further research is required.

A manic-depressive symptom self-report in optical scanable format.

PubMed

Glick, Henry A; McBride, Linda; Bauer, Mark S

2003-10-01

The Internal State Scale (ISS) is a self-report instrument that allows the simultaneous assessment of both manic and depressive symptoms in individuals with manic-depressive disorder. Prior work indicates that subscales are highly correlated with clinician ratings of mania and depression and provide a discriminant function that identifies individuals in manic/hypomanic, mixed, depressed, and euthymic mood states. A drawback to the ISS is that its items were developed in the visual analogue scale (VAS) format which is labor-intensive to score, particularly with repeat (e.g. daily) administration. A Likert-based format would allow quick and easy optical scanning for which scoring could be automated. To compare discriminating properties in Likert versus VAS format we re-analyzed previously collected data and collected new data: (a) VAS-based ISS scores from 86 subjects from a prior four-site study were re-analyzed by collapsing scores into 20 and then 10 Likert-based bins to assess loss of precision from collapsing scores, and (b) 24 additional subjects were administered the ISS in VAS and Likert formats to assess loss of precision due to instrument completion factors. Discriminant ability, including kappas and receiver operator characteristic curves, were unchanged across the two formats. Within-subjects reliability was uniformally high across formats. Likert-based scoring of the ISS can be used without loss of precision, thus making automated scoring of the ISS feasible. This format will be particularly useful for studies that require processing of large numbers of ISSs, such as those that collect frequent ratings over long periods of time and/or those that utilize large samples.

Deep Space Habitat Configurations Based On International Space Station Systems

NASA Technical Reports Server (NTRS)

Smitherman, David; Russell, Tiffany; Baysinger, Mike; Capizzo, Pete; Fabisinski, Leo; Griffin, Brand; Hornsby, Linda; Maples,Dauphne; Miernik, Janie

2012-01-01

A Deep Space Habitat (DSH) is the crew habitation module designed for long duration missions. Although humans have lived in space for many years, there has never been a habitat beyond low-Earth-orbit. As part of the Advanced Exploration Systems (AES) Habitation Project, a study was conducted to develop weightless habitat configurations using systems based on International Space Station (ISS) designs. Two mission sizes are described for a 4-crew 60-day mission, and a 4-crew 500-day mission using standard Node, Lab, and Multi-Purpose Logistics Module (MPLM) sized elements, and ISS derived habitation systems. These durations were selected to explore the lower and upper bound for the exploration missions under consideration including a range of excursions within the Earth-Moon vicinity, near earth asteroids, and Mars orbit. Current methods for sizing the mass and volume for habitats are based on mathematical models that assume the construction of a new single volume habitat. In contrast to that approach, this study explored the use of ISS designs based on existing hardware where available and construction of new hardware based on ISS designs where appropriate. Findings included a very robust design that could be reused if the DSH were assembled and based at the ISS and a transportation system were provided for its return after each mission. Mass estimates were found to be higher than mathematical models due primarily to the use of multiple ISS modules instead of one new large module, but the maturity of the designs using flight qualified systems have potential for improved cost, schedule, and risk benefits.

Deep Space Habitat Configurations Based on International Space Station Systems

NASA Technical Reports Server (NTRS)

Smitherman, David; Russell, Tiffany; Baysinger, Mike; Capizzo, Pete; Fabisinski, Leo; Griffin, Brand; Hornsby, Linda; Maples, Dauphne; Miernik, Janie

2012-01-01

A Deep Space Habitat (DSH) is the crew habitation module designed for long duration missions. Although humans have lived in space for many years, there has never been a habitat beyond low-Earth-orbit. As part of the Advanced Exploration Systems (AES) Habitation Project, a study was conducted to develop weightless habitat configurations using systems based on International Space Station (ISS) designs. Two mission sizes are described for a 4-crew 60-day mission, and a 4-crew 500-day mission using standard Node, Lab, and Multi-Purpose Logistics Module (MPLM) sized elements, and ISS derived habitation systems. These durations were selected to explore the lower and upper bound for the exploration missions under consideration including a range of excursions within the Earth-Moon vicinity, near earth asteroids, and Mars orbit. Current methods for sizing the mass and volume for habitats are based on mathematical models that assume the construction of a new single volume habitat. In contrast to that approach, this study explored the use of ISS designs based on existing hardware where available and construction of new hardware based on ISS designs where appropriate. Findings included a very robust design that could be reused if the DSH were assembled and based at the ISS and a transportation system were provided for its return after each mission. Mass estimates were found to be higher than mathematical models due primarily to the use of multiple ISS modules instead of one new large module, but the maturity of the designs using flight qualified systems have potential for improved cost, schedule, and risk benefits.

Comparison of SHOX and associated elements duplications distribution between patients (Lėri-Weill dyschondrosteosis/idiopathic short stature) and population sample.

PubMed

Hirschfeldova, Katerina; Solc, Roman

2017-09-05

The effect of heterozygous duplications of SHOX and associated elements on Lėri-Weill dyschondrosteosis (LWD) and idiopathic short stature (ISS) development is less distinct when compared to reciprocal deletions. The aim of our study was to compare frequency and distribution of duplications within SHOX and associated elements between population sample and LWD (ISS) patients. A preliminary analysis conducted on Czech population sample of 250 individuals compared to our previously reported sample of 352 ISS/LWD Czech patients indicated that rather than the difference in frequency of duplications it is the difference in their distribution. Particularly, there was an increased frequency of duplications residing to the CNE-9 enhancer in our LWD/ISS sample. To see whether the obtained data are consistent across published studies we made a literature survey to get published cases with SHOX or associated elements duplication and formed the merged LWD, the merged ISS, and the merged population samples. Relative frequency of particular region duplication in each of those merged samples were calculated. There was a significant difference in the relative frequency of CNE-9 enhancer duplications (11 vs. 3) and complete SHOX (exon1-6b) duplications (4 vs. 24) (p-value 0.0139 and p-value 0.000014, respectively) between the merged LWD sample and the merged population sample. We thus propose that partial SHOX duplications and small duplications encompassing CNE-9 enhancer could be highly penetrant alleles associated with ISS and LWD development. Copyright © 2017 Elsevier B.V. All rights reserved.

Thirsk in JPM

NASA Image and Video Library

2009-06-06

ISS020-E-007147 (6 June 2009) --- Canadian Space Agency astronaut Robert Thirsk, Expedition 20 flight engineer, performs an insertion of urine samples into the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) as part of the Nutritional Status Assessment (NUTRITION) study in the Japanese Kibo laboratory of the International Space Station.

Coleman prepares to insert samples into the MELFI

NASA Image and Video Library

2010-12-27

ISS026-E-023814 (27 Dec. 2010) --- NASA astronaut Catherine (Cady) Coleman, Expedition 26 flight engineer, works with the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) as part of the Nutritional Status Assessment (NUTRITION) study in the Japanese Kibo laboratory of the International Space Station.

Thirsk in JPM

NASA Image and Video Library

2009-06-06

ISS020-E-007140 (6 June 2009) --- Canadian Space Agency astronaut Robert Thirsk, Expedition 20 flight engineer, performs an insertion of urine samples into the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) as part of the Nutritional Status Assessment (NUTRITION) study in the Japanese Kibo laboratory of the International Space Station.

MELFI Urine Sample First Insertion

NASA Image and Video Library

2009-04-11

ISS019-E-005715 (11 April 2009) --- Astronaut Michael Barratt, Expedition 19/20 flight engineer, performs an insertion of urine samples into the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) as part of the Nutritional Status Assessment (NUTRITION) study in the Japanese Kibo laboratory of the International Space Station.

Photography of Coral Reefs from ISS

NASA Technical Reports Server (NTRS)

Robinson, Julie A.

2009-01-01

This viewgraph presentation reviews the uses of photography from the International Space Station (ISS) in studying Earth's coral reefs. The photographs include reefs in various oceans . The photographs have uses for science in assisting NASA mapping initiatives, distribution worldwide through ReefBase, and by biologist in the field.

Modeling International Space Station (ISS) Floating Potentials

NASA Technical Reports Server (NTRS)

Ferguson, Dale C.; Gardner, Barbara

2002-01-01

The floating potential of the International Space Station (ISS) as a function of the electron current collection of its high voltage solar array panels is derived analytically. Based on Floating Potential Probe (FPP) measurements of the ISS potential and ambient plasma characteristics, it is shown that the ISS floating potential is a strong function of the electron temperature of the surrounding plasma. While the ISS floating potential has so far not attained the pre-flight predicted highly negative values, it is shown that for future mission builds, ISS must continue to provide two-fault tolerant arc-hazard protection for astronauts on EVA.

A Dynamic/Anisotropic Low Earth Orbit (LEO) Ionizing Radiation Model

NASA Technical Reports Server (NTRS)

Badavi, Francis F.; West, Katie J.; Nealy, John E.; Wilson, John W.; Abrahms, Briana L.; Luetke, Nathan J.

2006-01-01

The International Space Station (ISS) provides the proving ground for future long duration human activities in space. Ionizing radiation measurements in ISS form the ideal tool for the experimental validation of ionizing radiation environmental models, nuclear transport code algorithms, and nuclear reaction cross sections. Indeed, prior measurements on the Space Transportation System (STS; Shuttle) have provided vital information impacting both the environmental models and the nuclear transport code development by requiring dynamic models of the Low Earth Orbit (LEO) environment. Previous studies using Computer Aided Design (CAD) models of the evolving ISS configurations with Thermo Luminescent Detector (TLD) area monitors, demonstrated that computational dosimetry requires environmental models with accurate non-isotropic as well as dynamic behavior, detailed information on rack loading, and an accurate 6 degree of freedom (DOF) description of ISS trajectory and orientation.

Neutral Orbital Altitude Density Effects on the International Space Station

NASA Technical Reports Server (NTRS)

Smith, O.E.; Adelfang, S. I.; Smith, R. E.

1997-01-01

One of the design requirements of the International Space Station (ISS) is that each year accelerations of one micro-g cannot be exceeded at the ISS internal payload location for 6 periods of not less than 30 consecutive days. Although there are other causes, this study deals only with the accelerations caused by atmospheric drag. The critical ambient neutral density, computed using the Marshall Engineering Thermosphere Model, required to produce accelerations of one micro-g on the ISS, is estimated using an atmospheric drag acceleration equation. Results show that the design requirements may be difficult to meet during periods of extremely high solar activity; the planned reboost and altitude strategies for the ISS may have to be revised to allow for the uncertainty in the prediction of neutral atmospheric density within the 100-day period established for orbital decay before reboost.

Re-Engineering the ISS Payload Operations Control Center During Increased Utilization and Critical Onboard Events

NASA Technical Reports Server (NTRS)

Dudley, Stephanie R. B.; Marsh, Angela L.

2014-01-01

With an increase in utilization and hours of payload operations being executed onboard the International Space Station (ISS), upgrading the NASA Marshall Space Flight Center (MSFC) Huntsville Operations Support Center (HOSC) ISS Payload Control Area (PCA) was essential to gaining efficiencies and assurance of current and future payload health and science return. PCA houses the Payload Operations Integration Center (POIC) responsible for the execution of all NASA payloads onboard the ISS. POIC Flight Controllers are responsible for the operation of voice, stowage, command, telemetry, video, power, thermal, and environmental control in support of ISS science experiments. The methodologies and execution of the PCA refurbishment were planned and performed within a four-month period in order to assure uninterrupted operation of ISS payloads and minimal impacts to payload operations teams. To vacate the PCA, three additional HOSC control rooms were reconfigured to handle ISS real-time operations, Backup Control Center (BCC) to Mission Control in Houston, simulations, and testing functions. This involved coordination and cooperation from teams of ISS operations controllers, multiple engineering and design disciplines, management, and construction companies performing an array of activities simultaneously and in sync delivering a final product with no issues that impacted the schedule. For each console operator discipline, studies of Information Technology (IT) tools and equipment layouts, ergonomics, and lines of sight were performed. Infusing some of the latest IT into the project was an essential goal in ensuring future growth and success of the ISS payload science returns. Engineering evaluations led to a state of the art Video Wall implementation and more efficient ethernet cabling distribution providing the latest products and the best solution for the POIC. These engineering innovations led to cost savings for the project. Constraints involved in the management of the project included executing over 450 crew-hours of ISS real-time payload operations including a major onboard communications upgrade, SpaceX un-berth, a Soyuz launch, roll-out of ISS live video and interviews from the POIC, annual BCC certification and hurricane season, and ISS simulations and testing. Continuous ISS payload operations were possible during the PCA facility modifications with the reconfiguration of four control rooms and standup of two temporary control areas. Another major restriction to the project was an ongoing facility upgrade that included a NASA Headquarters mandated replacement of all electrical and mechanical systems and replacement of an external generator. These upgrades required a facility power outage during the PCA upgrades. The project also encompassed console layout designs and ordering, amenities selections and ordering, excessing of old equipment, moves, disposal of old IT equipment, camera installations, facility tour re-schedules, and contract justifications. These were just some of the tasks needed for a successful project. This paper describes the logistics and lessons learned in upgrading a control center capability in the middle of complex real-time operations. Combining the efficiencies of controller interaction and new technology infusion were prime drivers for this upgrade to handle the increased utilization of science research on ISS. The success of this project could not jeopardize the current operations while these facility upgrades occurred.

International Space Station Utilization: Tracking Investigations from Objectives to Results

NASA Technical Reports Server (NTRS)

Ruttley, T. M.; Mayo, Susan; Robinson, J. A.

2011-01-01

Since the first module was assembled on the International Space Station (ISS), on-orbit investigations have been underway across all scientific disciplines. The facilities dedicated to research on ISS have supported over 1100 investigations from over 900 scientists representing over 60 countries. Relatively few of these investigations are tracked through the traditional NASA grants monitoring process and with ISS National Laboratory use growing, the ISS Program Scientist s Office has been tasked with tracking all ISS investigations from objectives to results. Detailed information regarding each investigation is now collected once, at the first point it is proposed for flight, and is kept in an online database that serves as a single source of information on the core objectives of each investigation. Different fields are used to provide the appropriate level of detail for research planning, astronaut training, and public communications. http://www.nasa.gov/iss-science/. With each successive year, publications of ISS scientific results, which are used to measure success of the research program, have shown steady increases in all scientific research areas on the ISS. Accurately identifying, collecting, and assessing the research results publications is a challenge and a priority for the ISS research program, and we will discuss the approaches that the ISS Program Science Office employs to meet this challenge. We will also address the online resources available to support outreach and communication of ISS research to the public. Keywords: International Space Station, Database, Tracking, Methods

Injury Severity Score coding: Data analyst v. emerging m-health technology.

PubMed

Spence, R T; Zargaran, E; Hameed, M; Fong, D; Shangguan, E; Martinez, R; Navsaria, P; Nicol, A

2016-09-08

The cost of Abbreviated Injury Scale (AIS) coding has limited its utility in areas of the world with the highest incidence of trauma. We hypothesised that emerging mobile health (m-health) technology could offer a cost-effective alternative to the current gold-standard AIS mechanism in a high-volume trauma centre in South Africa. A prospectively collected sample of consecutive patients admitted following a traumatic injury that required an operation during a 1-month period was selected for the study. AISs and Injury Severity Scores (ISSs) were generated by clinician-entered data using an m-health application (ISS eTHR) as well as by a team of AIS coders at Vancouver General Hospital, Canada (ISS VGH). Rater agreements for ISSs were analysed using Bland-Altman plots with 95% limits of agreement (LoA) and kappa statistics of the ISSs grouped into ordinal categories. Reliability was analysed using a two-way mixed-model intraclass correlation coefficient (ICC). Calibration and discrimination of univariate logistic regression models built to predict in-hospital complications using ISSs coded by the two methods were also compared. Fifty-seven patients were managed operatively during the study period. The mean age of the cohort was 27.2 years (range 14 - 62), and 96.3% were male. The mechanism of injury was penetrating in 93.4% of cases, of which 52.8% were gunshot injuries. The LoA fell within -8.6 - 9.4. The mean ISS difference was 0.4 (95% CI -0.8 - 1.6). The kappa statistic was 0.53. The ICC of the individual ISS was 0.88 (95% CI 0.81 - 0.93) and the categorical ISS was 0.81 (95% CI 0.68 - 0.87). Model performance to predict in-hospital complications using either the ISS eTHR or the ISS VGH was equivalent. ISSs calculated by the eTHR and gold-standard coding were comparable. Emerging m-health technology provides a cost-effective alternative for injury severity scoring.

International Space Station (ISS)

NASA Image and Video Library

2001-08-20

This image of the International Space Station (ISS) was photographed by one of the crewmembers of the STS-105 mission from the Shuttle Orbiter Discovery after separating from the ISS. The STS-105 mission was the 11th ISS assembly flight and its goals were the rotation of the ISS Expedition Two crew with Expedition Three crew, and the delivery of supplies utilizing the Italian-built Multipurpose Logistic Module (MPLM) Leonardo. Aboard Leonardo were six resupply stowage racks, four resupply stowage supply platforms, and two new scientific experiment racks, EXPRESS (Expedite the Processing of Experiments to the Space Station) Racks 4 and 5, which added science capabilities to the ISS. Another payload was the Materials International Space Station Experiment (MISSE), which included materials and other types of space exposure experiments mounted on the exterior of the ISS.

A comparison of "life threatening injury" concept in the Turkish Penal Code and trauma scoring systems.

PubMed

Fedakar, Recep; Aydiner, Ahmet Hüsamettin; Ercan, Ilker

2007-07-01

To compare accuracy and to check the suitability of the Glasgow Coma Scale (GCS), the Revised Trauma Score (RTS), the Injury Severity Score (ISS), the New Injury Severity Score (NISS) and the Trauma and Injury Severity Score (TRISS), the scoring systems widely used in international trauma studies, in the evaluation of the "life threatening injury" concept established by the Turkish Penal Code. The age, sex, type of trauma, type and localizations of wounds, GCS, RTS, ISS, NISS and TRISS values, the decision of life threatening injury of 627 trauma patients admitted to Emergency Department of the Uludag University Medical School Hospital in year 2003 were examined. A life-threatening injury was present in 35.2% of the cases examined. GCS, RTS, ISS, NISS and TRISS confirmed the decision of life threatening injury with percentages of 74.8%, 76.9%, 88.7%, 86.6% and 68.6%, respectively. The best cut-off point 14 was determined in the ISS system with 79.6% sensitivity and 93.6% specificity. All of the cases with sole linear skull fracture officially decided as life threatening injury had an ISS of 5, a NISS of 6 and the best scores of GCS (15), RTS (7.8408) and TRISS (100%). ISS and NISS appeared to be the best trauma scoring systems that can be used for the decision of life threatening injury, compared with GCS, RTS and TRISS. Thus, ISS and NISS can be acceptable for using the evaluation of the life threatening injury concept established by the Turkish Penal Code.

Validating the Injury Severity Score (ISS) in different populations: ISS predicts mortality better among Hispanics and females.

PubMed

Bolorunduro, O B; Villegas, C; Oyetunji, T A; Haut, E R; Stevens, K A; Chang, D C; Cornwell, E E; Efron, D T; Haider, A H

2011-03-01

The Injury Severity Score (ISS) is the most commonly used measure of injury severity. The score has been shown to have excellent predictive capability for trauma mortality and has been validated in multiple data sets. However, the score has never been tested to see if its discriminatory ability is affected by differences in race and gender. This study is aimed at validating the ISS in men and women and in three different race/ethnic groups using a nationwide database. Retrospective analysis of patients age 18-64 y in the National Trauma Data Bank 7.0 with blunt trauma was performed. ISS was categorized as mild (<9,) moderate (9-15), severe (16-25), and profound (>25). Logistic regression was done to measure the relative odds of mortality associated with a change in ISS categories. The discriminatory ability was compared using the receiver operating characteristics curves (ROC). A P value testing the equality of the ROC curves was calculated. Age stratified analyses were also conducted. A total of 872,102 patients had complete data for the analysis on ethnicity, while 763,549 patients were included in the gender analysis. The overall mortality rate was 3.7%. ROC in Whites was 0.8617, in Blacks 0.8586, and in Hispanics 0.8869. Hispanics have a statistically significant higher ROC (P value < 0.001). Similar results were observed within each age category. ROC curves were also significantly higher in females than in males. The ISS possesses excellent discriminatory ability in all populations as indicated by the high ROCs. Copyright © 2011 Elsevier Inc. All rights reserved.

Preliminary Analysis of ISS Maintenance History and Implications for Supportability of Future Missions

NASA Technical Reports Server (NTRS)

Watson, Kevin J.; Robbins, William W.

2004-01-01

The International Space Station (ISS) enables the study of supportability issues associated with long-duration human spaceflight. The ISS is a large, complex spacecraft that must be maintained by its crew. In contrast to the Space Shuttle Orbiter vehicle, but similar to spacecraft that will be component elements of future missions beyond low-Earth orbit, ISS does not return to the ground for servicing and provisioning of spares is severely constrained by transportation limits. Although significant technical support is provided by ground personnel, all hands-on maintenance tasks are performed by the crew. It is expected that future missions to distant destinations will be further limited by lack of resupply opportunities and will, eventually, become largely independent of ground support. ISS provides an opportunity to begin learning lessons that will enable future missions to be successful. Data accumulated over the first several years of ISS operations have been analyzed to gain a better understanding of maintenance-related workload. This analysis addresses both preventive and corrective maintenance and includes all U.S segment core systems. Systems and tasks that are major contributors to workload are identified. As further experience accrues, lessons will be learned that will influence future system designs so that they require less maintenance and, when maintenance is required, it can be performed more efficiently. By heeding the lessons of ISS it will be possible to identify system designs that should be more robust and point towards advances in both technology and design that will offer the greatest return on investment.

Evaluation of the Revised International Staging System in an independent cohort of unselected patients with multiple myeloma

PubMed Central

Kastritis, Efstathios; Terpos, Evangelos; Roussou, Maria; Gavriatopoulou, Maria; Migkou, Magdalini; Eleutherakis-Papaiakovou, Evangelos; Fotiou, Despoina; Ziogas, Dimitrios; Panagiotidis, Ioannis; Kafantari, Eftychia; Giannouli, Stavroula; Zomas, Athanasios; Konstantopoulos, Konstantinos; Dimopoulos, Meletios A.

2017-01-01

The Revised International Staging System (R-ISS) was recently introduced in order to improve risk stratification over that provided by the widely used standard International Staging System. In addition to the parameters of the standard system, the R-ISS incorporates the presence of chromosomal abnormalities detected by interphase fluorescence in situ hybridization [t(4;14), t(14;16) and del17p] and elevated serum lactate dehydrogenase. The R-ISS was formulated on the basis of a large dataset of selected patients who had participated in clinical trials and has not been validated in an independent cohort of unselected patients. Thus, we evaluated the R-ISS in 475 consecutive, unselected patients, treated in a single center. Our patients were older and more often had severe renal dysfunction than those in the original publication on the R-ISS. As regards distribution by group, 18% had R-ISS-1, 64.5% R-ISS-2 and 18% R-ISS-3. According to R-ISS group, the 5-year survival rate was 77%, 53% and 19% for R-ISS-1, -2 and -3, respectively (P<0.001). The R-ISS could identify three groups with distinct outcomes among patients treated with or without autologous stem cell transplantation, among those treated with either bortezomib-based or immunomodulatory drug-based primary therapy and in patients ≤65, 66–75 or >75 years. However, in patients with severe renal dysfunction the distinction between groups was less clear. In conclusion, our data in consecutive, unselected patients, with differences in the characteristics and treatment approaches compared to the original International Myeloma Working Group cohort, verified that R-ISS is a robust tool for risk stratification of newly diagnosed patients with symptomatic myeloma. PMID:27789676

Initial Results from the Floating Potential Measurement Unit aboard the International Space Station

NASA Technical Reports Server (NTRS)

Wright, Kenneth H., Jr.; Swenson, Charles; Thompson, Don; Barjatya, Aroh; Koontz, Steven L.; Schneider, Todd; Vaughn, Jason; Minow, Joseph; Craven, Paul; Coffey, Victoria;

ISS Ammonia Leak Detection Through X-Ray Fluorescence

NASA Technical Reports Server (NTRS)

Camp, Jordan; Barthelmy, Scott; Skinner, Gerry

2013-01-01

Ammonia leaks are a significant concern for the International Space Station (ISS). The ISS has external transport lines that direct liquid ammonia to radiator panels where the ammonia is cooled and then brought back to thermal control units. These transport lines and radiator panels are subject to stress from micrometeorites and temperature variations, and have developed small leaks. The ISS can accommodate these leaks at their present rate, but if the rate increased by a factor of ten, it could potentially deplete the ammonia supply and impact the proper functioning of the ISS thermal control system, causing a serious safety risk. A proposed ISS astrophysics instrument, the Lobster X-Ray Monitor, can be used to detect and localize ISS ammonia leaks. Based on the optical design of the eye of its namesake crustacean, the Lobster detector gives simultaneously large field of view and good position resolution. The leak detection principle is that the nitrogen in the leaking ammonia will be ionized by X-rays from the Sun, and then emit its own characteristic Xray signal. The Lobster instrument, nominally facing zenith for its astrophysics observations, can be periodically pointed towards the ISS radiator panels and some sections of the transport lines to detect and localize the characteristic X-rays from the ammonia leaks. Another possibility is to use the ISS robot arm to grab the Lobster instrument and scan it across the transport lines and radiator panels. In this case the leak detection can be made more sensitive by including a focused 100-microampere electron beam to stimulate X-ray emission from the leaking nitrogen. Laboratory studies have shown that either approach can be used to locate ammonia leaks at the level of 0.1 kg/day, a threshold rate of concern for the ISS. The Lobster instrument uses two main components: (1) a microchannel plate optic (also known as a Lobster optic) that focuses the X-rays and directs them to the focal plane, and (2) a CCD (charge coupled device) focal plane detector that reads out the position and energy of the X-rays, allowing a determination of the leak location. The effective area of the detection system is approximately 2 cm(exp2) at 1 keV. The Lobster astrophysics instrument, designed for monitoring the sky for Xray transients, gives high sensitivity along with large field of view (30×30deg) and good spatial resolution (1 arc min). This offers a significant benefit for detecting ISS ammonia leaks, since the goal is to localize small leaks as efficiently as possible.

Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization.

PubMed

Xu, Y; Ehringer, M; Yang, F; Sikela, J M

2001-06-01

Inbred long-sleep (ILS) and short-sleep (ISS) mice show significant central nervous system-mediated differences in sleep time for sedative dose of ethanol and are frequently used as a rodent model for ethanol sensitivity. In this study, we have used complementary DNA (cDNA) array hybridization methodology to identify genes that are differentially expressed between the brains of ILS and ISS mice. To carry out this analysis, we used both the gene discovery array (GDA) and the Mouse GEM 1 Microarray. GDA consists of 18,378 nonredundant mouse cDNA clones on a single nylon filter. Complex probes were prepared from total brain mRNA of ILS or ISS mice by using reverse transcription and 33P labeling. The labeled probes were hybridized in parallel to the gene array filters. Data from GDA experiments were analyzed with SQL-Plus and Oracle 8. The GEM microarray includes 8,730 sequence-verified clones on a glass chip. Two fluorescently labeled probes were used to hybridize a microarray simultaneously. Data from GEM experiments were analyzed by using the GEMTools software package (Incyte). Differentially expressed genes identified from each method were confirmed by relative quantitative reverse transcription-polymerase chain reaction (RT-PCR). A total of 41 genes or expressed sequence tags (ESTs) display significant expression level differences between brains of ILS and ISS mice after GDA, GEM1 hybridization, and quantitative RT-PCR confirmation. Among them, 18 clones were expressed higher in ILS mice, and 23 clones were expressed higher in ISS mice. The individual gene or EST's function and mapping information have been analyzed. This study identified 41 genes that are differentially expressed between brains of ILS and ISS mice. Some of them may have biological relevance in mediation of phenotypic variation between ILS and ISS mice for ethanol sensitivity. This study also demonstrates that parallel gene expression comparison with high-density cDNA arrays is a rapid and efficient way to discover potential genes and pathways involved in alcoholism and alcohol-related physiologic processes.

The evil of good is better: Making the case for basic life support transport for penetrating trauma victims in an urban environment.

PubMed

Rappold, Joseph F; Hollenbach, Kathryn A; Santora, Thomas A; Beadle, Dania; Dauer, Elizabeth D; Sjoholm, Lars O; Pathak, Abhijit; Goldberg, Amy J

2015-09-01

Controversy remains over the ideal way to transport penetrating trauma victims in an urban environment. Both advance life support (ALS) and basic life support (BLS) transports are used in most urban centers. A retrospective cohort study was conducted at an urban Level I trauma center. Victims of penetrating trauma transported by ALS, BLS, or police from January 1, 2008, to November 31, 2013, were identified. Patient survival by mode of transport and by level of care received was analyzed using logistic regression. During the study period, 1,490 penetrating trauma patients were transported by ALS (44.8%), BLS (15.6%), or police (39.6%) personnel. The majority of injuries were gunshot wounds (72.9% for ALS, 66.8% for BLS, 90% for police). Median transport minutes were significantly longer for ALS (16 minutes) than for BLS (14.5 minutes) transports (p = 0.012). After adjusting for transport time and Injury Severity Score (ISS), among victims with an ISS of 0 to 30, there was a 2.4-fold increased odds of death (95% confidence interval [CI], 1.3-4.4) if transported by ALS as compared with BLS. With an ISS of greater than 30, this relationship did not exist (odds ratio, 0.9; 95% CI, 0.3-2.7). When examined by type of care provided, patients with an ISS of 0 to 30 given ALS support were 3.7 times more likely to die than those who received BLS support (95% CI, 2.0-6.8). Among those with an ISS of greater than 30, no relationship was evident (odds ratio, 0.9; 95% CI, 0.3-2.7). Among penetrating trauma victims with an ISS of 30 or lower, an increased odds of death was identified for those treated and/or transported by ALS personnel. For those with an ISS of greater than 30, no survival advantage was identified with ALS transport or care. Results suggest that rapid transport may be more important than increased interventions. Therapeutic study, level IV.

Nutrition and Repository: Insertion of Urine Sample into MELFI

NASA Image and Video Library

2009-04-18

ISS019-E-010170 (18 April 2009) --- Astronaut Michael Barratt, Expedition 19/20 flight engineer, performs an insertion of urine samples into the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) as part of the Nutritional Status Assessment (NUTRITION) study in the Japanese Kibo laboratory of the International Space Station.

Coleman prepares to insert samples into the MELFI

NASA Image and Video Library

2010-12-27

ISS026-E-023768 (27 Dec. 2010) --- NASA astronaut Catherine (Cady) Coleman, Expedition 26 flight engineer, prepares to insert samples into the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) as part of the Nutritional Status Assessment (NUTRITION) study in the Japanese Kibo laboratory of the International Space Station.

Nutrition and Repository: Insertion of Urine Sample into MELFI

NASA Image and Video Library

2009-04-18

ISS019-E-010165 (18 April 2009) --- Astronaut Michael Barratt, Expedition 19/20 flight engineer, performs an insertion of urine samples into the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) as part of the Nutritional Status Assessment (NUTRITION) study in the Japanese Kibo laboratory of the International Space Station.

Spaceflight Standard Measures

NASA Technical Reports Server (NTRS)

Zwart, Sara R.; Mullenax, Carol; Bloomberg, Jacob; Crucian, Brian; Lee, Stuart; Ott, Mark; Reschke, Millard; Smith, Scott; Stenger, Michael; Roma, Pete

2018-01-01

The main goal is to ensure that a minimal set of measures is consistently captured from all ISS crewmembers until the end of ISS to characterize the effects of space. The data from these measures will placed in an archive managed by HRP and can be made available to studies via data sharing agreements.

Carbon Dioxide Removal Troubleshooting aboard the International Space Station (ISS) during Space Shuttle (STS) Docked Operations

NASA Technical Reports Server (NTRS)

Matty, Christopher M.; Cover, John M.

2009-01-01

The International Space Station (ISS) represents a largely closed-system habitable volume which requires active control of atmospheric constituents, including removal of exhaled Carbon Dioxide (CO2). The ISS provides a unique opportunity to observe system requirements for (CO2) removal. CO2 removal is managed by the Carbon Dioxide Removal Assembly (CDRA) aboard the US segment of ISS and by Lithium Hydroxide (LiOH) aboard the Space Shuttle (STS). While the ISS and STS are docked, various methods are used to balance the CO2 levels between the two vehicles, including mechanical air handling and management of general crew locations. Over the course of ISS operation, several unexpected anomalies have occurred which have required troubleshooting, including possible compromised performance of the CDRA and LiOH systems, and possible imbalance in CO2 levels between the ISS and STS while docked. This paper will cover efforts to troubleshoot the CO2 removal systems aboard the ISS and docked STS.

Quantitative Risk Modeling of Fire on the International Space Station

NASA Technical Reports Server (NTRS)

Castillo, Theresa; Haught, Megan

2014-01-01

The International Space Station (ISS) Program has worked to prevent fire events and to mitigate their impacts should they occur. Hardware is designed to reduce sources of ignition, oxygen systems are designed to control leaking, flammable materials are prevented from flying to ISS whenever possible, the crew is trained in fire response, and fire response equipment improvements are sought out and funded. Fire prevention and mitigation are a top ISS Program priority - however, programmatic resources are limited; thus, risk trades are made to ensure an adequate level of safety is maintained onboard the ISS. In support of these risk trades, the ISS Probabilistic Risk Assessment (PRA) team has modeled the likelihood of fire occurring in the ISS pressurized cabin, a phenomenological event that has never before been probabilistically modeled in a microgravity environment. This paper will discuss the genesis of the ISS PRA fire model, its enhancement in collaboration with fire experts, and the results which have informed ISS programmatic decisions and will continue to be used throughout the life of the program.

International Space Station Configuration Analysis and Integration

NASA Technical Reports Server (NTRS)

Anchondo, Rebekah

2016-01-01

Ambitious engineering projects, such as NASA's International Space Station (ISS), require dependable modeling, analysis, visualization, and robotics to ensure that complex mission strategies are carried out cost effectively, sustainably, and safely. Learn how Booz Allen Hamilton's Modeling, Analysis, Visualization, and Robotics Integration Center (MAVRIC) team performs engineering analysis of the ISS Configuration based primarily on the use of 3D CAD models. To support mission planning and execution, the team tracks the configuration of ISS and maintains configuration requirements to ensure operational goals are met. The MAVRIC team performs multi-disciplinary integration and trade studies to ensure future configurations meet stakeholder needs.

Improving the Estimates of International Space Station (ISS) Induced K-Factor Failure Rates for On-Orbit Replacement Unit (ORU) Supportability Analyses

NASA Technical Reports Server (NTRS)

Anderson, Leif F.; Harrington, Sean P.; Omeke, Ojei, II; Schwaab, Douglas G.

2009-01-01

This is a case study on revised estimates of induced failure for International Space Station (ISS) on-orbit replacement units (ORUs). We devise a heuristic to leverage operational experience data by aggregating ORU, associated function (vehicle sub -system), and vehicle effective' k-factors using actual failure experience. With this input, we determine a significant failure threshold and minimize the difference between the actual and predicted failure rates. We conclude with a discussion on both qualitative and quantitative improvements the heuristic methods and potential benefits to ISS supportability engineering analysis.

Expedition 8 Crew Interview: Pedro Duque

NASA Technical Reports Server (NTRS)

2003-01-01

European Space Agency (ESA) astronaut Pedro Duque is interviewed in preparation for his flight to and eight day stay on the International Space Station (ISS) as part of the Cervantes mission. Duque arrived on the ISS with the Expedition 8 crew onboard a Soyuz TMA-3, the seventh Soyuz flight to the station. He departed from the ISS on a Soyuz TMA-2 with the Expedition 7 crew of the ISS. In the video, Duque answers questions on: the goals of his flight; his life and career path; the Columbus Module, which ESA will contribute to the ISS, the ride onboard a Soyuz, and the importance of the ISS.

Using the ISS as a Testbed to Prepare for the Next Generation of Space-Based Telescopes

NASA Technical Reports Server (NTRS)

Ess, Kim; Thronson, Harley; Boyles, Mark; Sparks, William; Postman, Marc; Carpenter, Kenneth

2012-01-01

The ISS provides a unique opportunity to develop the technologies and operational capabilities necessary to assemble future large space telescopes that may be used to investigate planetary systems around neighboring stars. Assembling telescopes in space is a paradigm-shifting approach to space astronomy. Using the ISS as a testbed will reduce the technical risks of implementing this major scientific facility, such as laser metrology and wavefront sensing and control (WFSC). The Optical Testbed and Integration on ISS eXperiment (OpTIIX) will demonstrate the robotic assembly of major components, including the primary and secondary mirrors, to mechanical tolerances using existing ISS infrastructure, and the alignment of the optical elements to a diffraction-limited optical system in space. Assembling the optical system and removing and replacing components via existing ISS capabilities, such as the Special Purpose Dexterous Manipulator (SPDM) or the ISS flight crew, allows for future experimentation and repair, if necessary. First flight on ISS for OpTIIX, a small 1.5 meter optical telescope, is planned for 2015. In addition to demonstration of key risk-retiring technologies, the OpTIIX program includes a public outreach program to show the broad value of ISS utilization.

Design And Testing of The Floating Potential Probe For ISS

NASA Technical Reports Server (NTRS)

Hillard, G. Barry; Ferguson, Dale C.

2001-01-01

Flight 4A was an especially critical mission for the International Space Station (ISS). For the first time, the high voltage solar arrays generated significant amounts of power and long predicted environmental interactions (high negative floating potential and concomitant dielectric charging) became serious concerns. Furthermore, the same flight saw the Plasma Contacting Unit (PCU) deployed and put into operation to mitigate and control these effects. The ISS program office has recognized the critical need to verify, by direct measurement, that ISS does not charge to unacceptable levels. A Floating Potential Probe (FPP) was therefore deployed on ISS to measure ISS floating potential relative to the surrounding plasma and to measure relevant plasma parameters. The primary objective of FPP is to verify that ISS floating potential does not exceed the specified level of 40 volts with respect to the ambient. Since it is expected that in normal operations the PCU will maintain ISS within this specification, it is equivalent to say that the objective of FPP is to monitor the functionality of the PCU. In this paper, we report on the design and testing of the ISS FPP. In a separate paper, the operations and results obtained so far by the FPP will be presented.

International Space Station Accomplishments Update: Scientific Discovery, Advancing Future Exploration, and Benefits Brought Home to Earth

NASA Technical Reports Server (NTRS)

Thumm, Tracy; Robinson, Julie A.; Alleyne, Camille; Hasbrook, Pete; Mayo, Susan; Johnson-Green, Perry; Buckley, Nicole; Karabadzhak, George; Kamigaichi, Shigeki; Umemura, Sayaka;

International space station accomplishments update: Scientific discovery, advancing future exploration, and benefits brought home to earth

NASA Astrophysics Data System (ADS)

Thumm, Tracy; Robinson, Julie A.; Alleyne, Camille; Hasbrook, Pete; Mayo, Susan; Buckley, Nicole; Johnson-Green, Perry; Karabadzhak, George; Kamigaichi, Shigeki; Umemura, Sayaka; Sorokin, Igor V.; Zell, Martin; Istasse, Eric; Sabbagh, Jean; Pignataro, Salvatore

2014-10-01

Throughout the history of the International Space Station (ISS), crews on board have conducted a variety of scientific research and educational activities. Well into the second year of full utilization of the ISS laboratory, the trend of scientific accomplishments and educational opportunities continues to grow. More than 1500 investigations have been conducted on the ISS since the first module launched in 1998, with over 700 scientific publications. The ISS provides a unique environment for research, international collaboration and educational activities that benefit humankind. This paper will provide an up to date summary of key investigations, facilities, publications, and benefits from ISS research that have developed over the past year. Discoveries in human physiology and nutrition have enabled astronauts to return from ISS with little bone loss, even as scientists seek to better understand the new puzzle of “ocular syndrome” affecting the vision of up to half of astronauts. The geneLAB campaign will unify life sciences investigations to seek genomic, proteomic and metabolomics of the effect of microgravity on life as a whole. Combustion scientists identified a new “cold flame” phenomenon that has the potential to improve models of efficient combustion back on Earth. A significant number of instruments in Earth remote sensing and astrophysics are providing new access to data or nearing completion for launch, making ISS a significant platform for understanding of the Earth system and the universe. In addition to multidisciplinary research, the ISS partnership conducts a myriad of student led research investigations and educational activities aimed at increasing student interest in science, technology, engineering and mathematics (STEM). Over the past year, the ISS partnership compiled new statistics of the educational impact of the ISS on students around the world. More than 43 million students, from kindergarten to graduate school, with more than 28 million teachers located in 49 countries have participated in some aspect of ISS educational activities. These activities include student-developed investigations, education competitions and classroom versions of ISS investigations, participating in ISS investigator experiments, ISS hardware development, educational demonstrations and cultural activities. Through the many inquiry-based educational activities, students and teachers are encouraged to participate in the ISS program thus motivating the next generation of students to pursue careers in STEM.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e103580 - iss042e104044). Shows night time Earth views. Solar Array Wing (SAW) and Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e196791 - iss042e197504). Shows Earth views. Day time views turn into night time views. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS 7A.1 Flight Control Team Photo in BFCR

NASA Image and Video Library

2001-08-17

JSC2001-02225 (17 August 2001) --- The members of the STS-105/ISS 7A.1 Orbit 2 team pose for a group portrait in the International Space Station (ISS) flight control room (BFCR) in Houston’s Mission Control Center (MCC). Orbit 2 flight director Rick LaBrode (front right) holds the STS-105 mission logo, and Astronaut Joan E. Higginbotham, ISS spacecraft communicator (CAPCOM), holds the ISS 7A.1 mission logo.

An Initial Strategy for Commercial Industry Awareness of the International Space Station

NASA Technical Reports Server (NTRS)

Jorgensen, Catherine A.

1999-01-01

While plans are being developed to utilize the ISS for scientific research, and human and microgravity experiments, it is time to consider the future of the ISS as a world-wide commercial marketplace developed from a government owned, operated and controlled facility. Commercial industry will be able to seize this opportunity to utilize the ISS as a unique manufacturing platform and engineering testbed for advanced technology. NASA has begun the strategic planning of the evolution and commercialization of the ISS. The Pre-Planned Program Improvement (P3I) Working Group at NASA is assessing the future ISS needs and technology plans to enhance ISS performance. Some of these enhancements will allow the accommodation of commercial applications and the Human Exploration and Development of Space mission support. As this information develops, it is essential to disseminate this information to commercial industry, targeting not only the private and public space sector but also the non-aerospace commercial industries. An approach is presented for early distribution of this information via the ISS Evolution Data book that includes ISS baseline system information, baseline utilization and operations plans, advanced technologies, future utilization opportunities, ISS evolution and Design Reference Missions (DRM). This information source and tool can be used as catalyst in the commercial world for the generation of ideas and options to enhance the current capabilities of the ISS.

Open for business: A New Approach to Commercialisation of the International Space Station

NASA Astrophysics Data System (ADS)

Master Of Space Studies 1998-1999 (MSS4) Class

2000-01-01

The International Space Station (ISS) is the result of collaboration between fifteen countries (IGA, 1998). Originally planned as a scientific facility, a shift in policy of the partners has recently occurred towards commercialisation of the Station. Open for Business: A New Approach to Commercialisation of the International Space Station is written in response to this policy shift. It sets out to identify the major constraints in which the potential commercial user must operate and proposes solutions for both commercial user and the partner space agencies to facilitate this commercialisation process. In a time when space-faring nations face reduced fiscal resources and increasing pressure from their constituencies to justify the huge costs of the ISS, commercialising utilisation seems a logical solution. Clearly, successful commercialisation can help recover some of the development and operating costs of the ISS. The structure of Open for Business is divided into two main parts. Part One is entitled ``Constraint and Solutions.'' It proposes new solutions to existing constraint to ISS commercialisation in areas of policy, law, technology and business. The conclusions of Part One are integrated and unified into A New Approach towards ISS commercialisation. This approach is then applied in Part Two to two case studies: the International Space Satellite Servicing Station (I4S) and protein crystallization. Open for Business then concludes with a recommended approach to the future of ISS commercialisation. .

Assessment of RFID Read Accuracy for ISS Water Kit

NASA Technical Reports Server (NTRS)

Chu, Andrew

2011-01-01

The Space Life Sciences Directorate/Medical Informatics and Health Care Systems Branch (SD4) is assessing the benefits Radio Frequency Identification (RFID) technology for tracking items flown onboard the International Space Station (ISS). As an initial study, the Avionic Systems Division Electromagnetic Systems Branch (EV4) is collaborating with SD4 to affix RFID tags to a water kit supplied by SD4 and studying the read success rate of the tagged items. The tagged water kit inside a Cargo Transfer Bag (CTB) was inventoried using three different RFID technologies, including the Johnson Space Center Building 14 Wireless Habitat Test Bed RFID portal, an RFID hand-held reader being targeted for use on board the ISS, and an RFID enclosure designed and prototyped by EV4.

Investigations of a simulated geomagnetic field experienced by the International Space Station on attentional performance

NASA Astrophysics Data System (ADS)

Del Seppia, C.; Mezzasalma, L.; Messerotti, M.; Cordelli, A.; Ghione, S.

2009-01-01

We have previously reported that the exposure to an abnormal magnetic field simulating the one encountered by the International Space Station (ISS) orbiting around the Earth may enhance autonomic response to emotional stimuli. Here we report the results of the second part of that study which tested whether this field also affects cognitive functions. Twenty-four volunteers participated in the study, 12 exposed to the natural geomagnetic field and 12 to the magnetic field encountered by ISS. The test protocol consisted of a set of eight tests chosen from a computerized test battery for the assessment of attentional performance. The duration of exposure was 90 min. No effect of exposure to ISS magnetic field was observed on attentional performance.

[Bone metabolism in human space flight and bed rest study].

PubMed

Ohshima, Hiroshi; Mukai, Chiaki

2008-09-01

Japanese Experiment Module "KIBO" is Japan's first manned space facility and will be operated as part of the international space station (ISS) . KIBO operations will be monitored and controlled from Tsukuba Space Center. In Japan, after the KIBO element components are fully assembled and activated aboard the ISS, Japanese astronauts will stay on the ISS for three or more months, and full-scale experiment operations will begin. Bone loss and renal stone are significant medical concerns for long duration human space flight. This paper will summarize the results of bone loss, calcium balance obtained from the American and Russian space programs, and ground-base analog bedrest studies. Current in-flight training program, nutritional recommendations and future countermeasure plans for station astronauts are also described.

NASA Education Activities on the International Space Station: A National Laboratory for Inspiring, Engaging, Educating and Employing the Next Generation

NASA Technical Reports Server (NTRS)

Severance, Mark T.; Tate-Brown, Judy; McArthur, Cynthia L.

2010-01-01

The International Space Station (ISS) National Lab Education Project has been created as a part of the ISS National Lab effort mandated by the U.S. Congress The project seeks to expand ISS education of activities so that they reach a larger number of students with clear educational metrics of accomplishments. This paper provides an overview of several recent ISS educational payloads and activities. The expected outcomes of the project, consistent with those of the NASA Office of Education, are also described. NASA performs numerous education activities as part of its ISS program. These cover the gamut from formal to informal educational opportunities in grades Kindergarten to grade 12, Higher Education (undergraduate and graduate University) and informal educational venues (museums, science centers, exhibits). Projects within the portfolio consist of experiments performed onboard the ISS using onboard resources which require no upmass, payloads flown to ISS or integrated into ISS cargo vehicles, and ground based activities that follow or complement onboard activities. Examples include ground based control group experiments, flight or experiment following lesson plans, ground based activities involving direct interaction with ISS or ground based activities considering ISS resources in their solution set. These projects range from totally NASA funded to projects which partner with external entities. These external agencies can be: other federal, state or local government agencies, commercial entities, universities, professional organizations or non-profit organizations. This paper will describe the recent ISS education activities and discuss the approach, outcomes and metrics associated with the projects.

Measurements of the neutron dose and energy spectrum on the International Space Station during expeditions ISS-16 to ISS-21.

PubMed

Smith, M B; Akatov, Yu; Andrews, H R; Arkhangelsky, V; Chernykh, I V; Ing, H; Khoshooniy, N; Lewis, B J; Machrafi, R; Nikolaev, I; Romanenko, R Y; Shurshakov, V; Thirsk, R B; Tomi, L

2013-01-01

As part of the international Matroshka-R and Radi-N experiments, bubble detectors have been used on board the ISS in order to characterise the neutron dose and the energy spectrum of neutrons. Experiments using bubble dosemeters inside a tissue-equivalent phantom were performed during the ISS-16, ISS-18 and ISS-19 expeditions. During the ISS-20 and ISS-21 missions, the bubble dosemeters were supplemented by a bubble-detector spectrometer, a set of six detectors that was used to determine the neutron energy spectrum at various locations inside the ISS. The temperature-compensated spectrometer set used is the first to be developed specifically for space applications and its development is described in this paper. Results of the dose measurements indicate that the dose received at two different depths inside the phantom is not significantly different, suggesting that bubble detectors worn by a person provide an accurate reading of the dose received inside the body. The energy spectra measured using the spectrometer are in good agreement with previous measurements and do not show a strong dependence on the precise location inside the station. To aid the understanding of the bubble-detector response to charged particles in the space environment, calculations have been performed using a Monte-Carlo code, together with data collected on the ISS. These calculations indicate that charged particles contribute <2% to the bubble count on the ISS, and can therefore be considered as negligible for bubble-detector measurements in space.

Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models

NASA Astrophysics Data System (ADS)

Badavi, Francis F.; Walker, Steven A.; Santos Koos, Lindsey M.

2015-04-01

The completion of the International Space Station (ISS) in 2011 has provided the space research community with an ideal evaluation and testing facility for future long duration human activities in space. Ionized and secondary neutral particles radiation measurements inside ISS form the ideal tool for validation of radiation environmental models, nuclear reaction cross sections and transport codes. Studies using thermo-luminescent detectors (TLD), tissue equivalent proportional counter (TPEC), and computer aided design (CAD) models of early ISS configurations confirmed that, as input, computational dosimetry at low Earth orbit (LEO) requires an environmental model with directional (anisotropic) capability to properly describe the exposure of trapped protons within ISS. At LEO, ISS encounters exposure from trapped electrons, protons and geomagnetically attenuated galactic cosmic rays (GCR). For short duration studies at LEO, one can ignore trapped electrons and ever present GCR exposure contributions during quiet times. However, within the trapped proton field, a challenge arises from properly estimating the amount of proton exposure acquired. There exist a number of models to define the intensity of trapped particles. Among the established trapped models are the historic AE8/AP8, dating back to the 1980s and the recently released AE9/AP9/SPM. Since at LEO electrons have minimal exposure contribution to ISS, this work ignores the AE8 and AE9 components of the models and couples a measurement derived anisotropic trapped proton formalism to omnidirectional output from the AP8 and AP9 models, allowing the assessment of the differences between the two proton models. The assessment is done at a target point within the ISS-11A configuration (circa 2003) crew quarter (CQ) of Russian Zvezda service module (SM), during its ascending and descending nodes passes through the south Atlantic anomaly (SAA). The anisotropic formalism incorporates the contributions of proton narrow pitch angle (PA) and east-west (EW) effects. Within SAA, the EW anisotropy results in different level of exposure to each side of the ISS Zvezda SM, allowing angular evaluation of the anisotropic proton spectrum. While the combined magnitude of PA and EW effects at LEO depends on a multitude of factors such as trapped proton energy, orientation and altitude of the spacecraft along the velocity vector, this paper draws quantitative conclusions on the combined anisotropic magnitude differences within ISS SM target point between AP8 and AP9 models.

Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models.

PubMed

Badavi, Francis F; Walker, Steven A; Santos Koos, Lindsey M

2015-04-01

The completion of the International Space Station (ISS) in 2011 has provided the space research community with an ideal evaluation and testing facility for future long duration human activities in space. Ionized and secondary neutral particles radiation measurements inside ISS form the ideal tool for validation of radiation environmental models, nuclear reaction cross sections and transport codes. Studies using thermo-luminescent detectors (TLD), tissue equivalent proportional counter (TPEC), and computer aided design (CAD) models of early ISS configurations confirmed that, as input, computational dosimetry at low Earth orbit (LEO) requires an environmental model with directional (anisotropic) capability to properly describe the exposure of trapped protons within ISS. At LEO, ISS encounters exposure from trapped electrons, protons and geomagnetically attenuated galactic cosmic rays (GCR). For short duration studies at LEO, one can ignore trapped electrons and ever present GCR exposure contributions during quiet times. However, within the trapped proton field, a challenge arises from properly estimating the amount of proton exposure acquired. There exist a number of models to define the intensity of trapped particles. Among the established trapped models are the historic AE8/AP8, dating back to the 1980s and the recently released AE9/AP9/SPM. Since at LEO electrons have minimal exposure contribution to ISS, this work ignores the AE8 and AE9 components of the models and couples a measurement derived anisotropic trapped proton formalism to omnidirectional output from the AP8 and AP9 models, allowing the assessment of the differences between the two proton models. The assessment is done at a target point within the ISS-11A configuration (circa 2003) crew quarter (CQ) of Russian Zvezda service module (SM), during its ascending and descending nodes passes through the south Atlantic anomaly (SAA). The anisotropic formalism incorporates the contributions of proton narrow pitch angle (PA) and east-west (EW) effects. Within SAA, the EW anisotropy results in different level of exposure to each side of the ISS Zvezda SM, allowing angular evaluation of the anisotropic proton spectrum. While the combined magnitude of PA and EW effects at LEO depends on a multitude of factors such as trapped proton energy, orientation and altitude of the spacecraft along the velocity vector, this paper draws quantitative conclusions on the combined anisotropic magnitude differences within ISS SM target point between AP8 and AP9 models. Copyright © 2015 The Committee on Space Research (COSPAR). All rights reserved.

ISS Expedition 42 Time Lapse Video of Earth

NASA Image and Video Library

2015-05-18

This time lapse video taken during ISS Expedition 42 is assembled from JSC still photo collection (still photos iss042e218184 - iss042e219070 ). Shows night time views over Egypt, Sinai, Saudi Arabia, Jordan and Israel. Space Station Remote Manipulator System (SSRMS) or Canadarm in foreground.

ISS Expedition 45 / 46 Underwater Crew Training

NASA Image and Video Library

2015-02-03

Underwater camera views of ISS Expedition 45 (Soyuz 42) crewmember Scott Kelly and ISS Expedition 46 (Soyuz 43) crewmember Kjell Lindgren during ISS Extravehicular Activity (EVA) Maintenance 9 Training (PMA/PMM Relocate) at JSC's Neutral Buoyancy Lab (NBL) Pool Deck at Sonny Carter Training Facility (SCTF). TIME magazine film crew filming activities.

ISS Efforts to Fully Utilize its Target Acquisition Capability Serves as an Analog for Future Laser Pointing Communications Systems

NASA Technical Reports Server (NTRS)

Jackson, Dan

2017-01-01

The ISS is an outstanding platform for developing, testing and refining laser communications systems for future exploration. A recent ISS project which improved ISS communications satellite acquisition performance proves the platform’s utility as a laser communications systems testbed.

Challenges in Evaluating Relationships Between Quantitative Data (Carbon Dioxide) and Qualitative Data (Self-Reported Visual Changes)

NASA Technical Reports Server (NTRS)

Mendez, C. M.; Foy, M.; Mason, S.; Wear, M. L.; Meyers, V.; Law, J.; Alexander, D.; Van Baalen, M.

2014-01-01

Understanding the nuances in clinical data is critical in developing a successful data analysis plan. Carbon dioxide (CO2) data are collected on board the International Space Station (ISS) in a continuous stream. Clinical data on ISS are primarily collected via conversations between individual crewmembers and NASA Flight Surgeons during weekly Private Medical Conferences (PMC). Law, et.al, 20141 demonstrated a statistically significant association between weekly average CO2 levels on ISS and self-reported headaches over the reporting period from March 14, 2001 to May 31, 2012. The purpose of this analysis is to describe the evaluation of a possible association between visual changes and CO2 levels on ISS and to discuss challenges in developing an appropriate analysis plan. METHODS & PRELIMINARY RESULTS: A first analysis was conducted following the same study design as the published work on CO2 and self-reported headaches1; substituting self-reported changes in visual acuity in place of self-reported headaches. The analysis demonstrated no statistically significant association between visual impairment characterized by vision symptoms self-reported during PMCs and ISS average CO2 levels over ISS missions. Closer review of the PMC records showed that vision outcomes are not well-documented in terms of clinical severity, timing of onset, or timing of resolution, perhaps due to the incipient nature of vision changes. Vision has been monitored in ISS crewmembers, pre- and post-flight, using standard optometry evaluations. In-flight visual assessments were limited early in the ISS program, primarily consisting of self-perceived changes reported by crewmembers. Recently, on-orbit capabilities have greatly improved. Vision data ranges from self-reported post-flight changes in visual acuity, pre- to postflight changes identified during fundoscopic examination, and in-flight progression measured by advanced on-orbit clinical imaging capabilities at predetermined testing intervals. In contrast, CO2 data are recorded in a continuous stream over time; however, for the initial analysis this data was categorized into weekly averages.

Ribo HRM--detection of inter- and intra-species polymorphisms within ribosomal DNA by high resolution melting analysis supported by application of artificial allelic standards.

PubMed

Masny, Aleksander; Jagiełło, Agata; Płucienniczak, Grażyna; Golab, Elzbieta

2012-09-01

Ribo HRM, a single-tube PCR and high resolution melting (HRM) assay for detection of polymorphisms in the large subunit ribosomal DNA expansion segment V, was developed on a Trichinella model. Four Trichinella species: T. spiralis (isolates ISS3 and ISS160), T. nativa (isolates ISS10 and ISS70), T. britovi (isolates ISS2 and ISS392) and T. pseudospiralis (isolates ISS13 and ISS1348) were genotyped. Cloned allelic variants of the expansion segment V were used as standards to prepare reference HRM curves characteristic for single sequences and mixtures of several cloned sequences imitating allelic composition detected in Trichinella isolates. Using the primer pair Tsr1 and Trich1bi, it was possible to amplify a fragment of the ESV and detect PCR products obtained from the genomic DNA of pools of larvae belonging to the four investigated species: T. pseudospiralis, T. spiralis, T. britovi and T. nativa, in a single tube Real-Time PCR reaction. Differences in the shape of the HRM curves of Trichinella isolates suggested the presence of differences between examined isolates of T. nativa, T. britovi and T. pseudospiralis species. No differences were observed between T. spiralis isolates. The presence of polymorphisms within the amplified ESV sequence fragment of T. nativa T. britovi and T. pseudospiralis was confirmed by sequencing of the cloned PCR products. Novel sequences were discovered and deposited in GenBank (GenBank IDs: JN971020-JN971027, JN120902.1, JN120903.1, JN120904.1, JN120906.1, JN120905.1). Screening the ESV region of Trichinella for polymorphism is possible using the genotyping assay Ribo HRM at the current state of its development. The Ribo HRM assay could be useful in phylogenetic studies of the Trichinella genus. Copyright © 2012 Elsevier B.V. All rights reserved.

Resilient microorganisms in dust samples of the International Space Station-survival of the adaptation specialists.

PubMed

Mora, Maximilian; Perras, Alexandra; Alekhova, Tatiana A; Wink, Lisa; Krause, Robert; Aleksandrova, Alina; Novozhilova, Tatiana; Moissl-Eichinger, Christine

2016-12-20

The International Space Station (ISS) represents a unique biotope for the human crew but also for introduced microorganisms. Microbes experience selective pressures such as microgravity, desiccation, poor nutrient-availability due to cleaning, and an increased radiation level. We hypothesized that the microbial community inside the ISS is modified by adapting to these stresses. For this reason, we analyzed 8-12 years old dust samples from Russian ISS modules with major focus on the long-time surviving portion of the microbial community. We consequently assessed the cultivable microbiota of these samples in order to analyze their extremotolerant potential against desiccation, heat-shock, and clinically relevant antibiotics. In addition, we studied the bacterial and archaeal communities from the stored Russian dust samples via molecular methods (next-generation sequencing, NGS) and compared our new data with previously derived information from the US American ISS dust microbiome. We cultivated and identified in total 85 bacterial, non-pathogenic isolates (17 different species) and 1 fungal isolate from the 8-12 year old dust samples collected in the Russian segment of the ISS. Most of these isolates exhibited robust resistance against heat-shock and clinically relevant antibiotics. Microbial 16S rRNA gene and archaeal 16S rRNA gene targeting Next Generation Sequencing showed signatures of human-associated microorganisms (Corynebacterium, Staphylococcus, Coprococcus etc.), but also specifically adapted extremotolerant microorganisms. Besides bacteria, the detection of archaeal signatures in higher abundance was striking. Our findings reveal (i) the occurrence of living, hardy microorganisms in archived Russian ISS dust samples, (ii) a profound resistance capacity of ISS microorganisms against environmental stresses, and (iii) the presence of archaeal signatures on board. In addition, we found indications that the microbial community in the Russian segment dust samples was different to recently reported US American ISS microbiota.

The VASIMR[registered trademark] VF-200-1 ISS Experiment as a Laboratory for Astrophysics

NASA Technical Reports Server (NTRS)

Glover Tim W.; Squire, Jared P.; Longmier, Benjamin; Cassady, Leonard; Ilin, Andrew; Carter, Mark; Olsen, Chris S.; McCaskill, Greg; Diaz, Franklin Chang; Girimaji, Sharath;

Expedition 8 Crew Interviews: C. Michael Foale - CDR

NASA Technical Reports Server (NTRS)

2003-01-01

C. Michael Foale, Commander of the Expedition 8 crew to the International Space Station (ISS), answers interview questions in this video. The questions cover: 1) The goals of the Expedition; 2) How his Mir experience prepared him for long-duration spaceflight; 3) The reaction the Columbia accident where he was training in Star City, Russia; 4) Why the rewards of spaceflight are worth the risks; 5) Why he wanted to become an astronaut; 6) His career path; 7) His influences; 8) His path of study; 9) His responsibilities on a mission; 10) What a Soyuz capsule is like; 11) What the oncoming and offgoing ISS crews will do together; 12) How the ISS science mission will be advanced during his stay; 13) Training and plans for extravehicular activity (EVA); 14) Return to Flight of Shuttle; 15) What is needed to make his mission a success; 16) The most valuable contribution of the ISS.

The VASIMR® VF-200-1 ISS Experiment as a Laboratory for Astrophysics

NASA Astrophysics Data System (ADS)

Glover, T.; Squire, J. P.; Longmier, B. W.; Carter, M. D.; Ilin, A. V.; Cassady, L. D.; Olsen, C. S.; Chang Díaz, F.; McCaskill, G. E.; Bering, E. A.; Garrison, D.; Girimaji, S.; Araya, D.; Morin, L.; Shebalin, J. V.

2010-12-01

The VASIMR® Flight Experiment (VF-200-1) will be tested in space aboard the International Space Station (ISS) in about four years. It will consist of two 100 kW parallel plasma engines with opposite magnetic dipoles, resulting in a near zero-torque magnetic system. Electrical energy will come from ISS at low power level, be stored in batteries and used to fire the engine at 200 kW. The VF-200-1 project will provide a unique opportunity on the ISS National Laboratory for astrophysicists and space physicists to study the dynamic evolution of an expanding and reconnecting plasma loop. Here, we review the status of the project and discuss our current plans for computational modeling and in situ observation of a dynamic plasma loop on an experimental platform in low-Earth orbit. The VF-200-1 project is still in the early stages of development and we welcome new collaborators.

AES Water Architecture Study Interim Results

NASA Technical Reports Server (NTRS)

Sarguisingh, Miriam J.

2012-01-01

The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems in order to enable NASA human exploration missions beyond low earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near term missions beyond LEO. The secondary objective is to continue to advance mid-readiness level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near and long term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit environmental control and life support systems (ECLSS) definition. This study is being performed in three phases. Phase I of this study established the scope of the study through definition of the mission requirements and constraints, as well as indentifying all possible WRS configurations that meet the mission requirements. Phase II of this study focused on the near term space exploration objectives by establishing an ISS-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

Leadership and Cultural Challenges in Operating the International Space Station

NASA Technical Reports Server (NTRS)

Clement, J. L.; Ritsher, J. B.; Saylor, S. A.; Kanas, N.

2006-01-01

Operating the International Space Station (ISS) involves an indefinite, continuous series of long-duration international missions, and this requires an unprecedented degree of cooperation across multiple sites, organizations, and nations. ISS flight controllers have had to find ways to maintain effective team performance in this challenging new context. The goal of this study was to systematically identify and evaluate the major leadership and cultural challenges faces by ISS flight controllers, and to highlight the approaches that they have found most effective to surmount these challenges. We conducted a qualitative survey using a semi-structured interview. Subjects included 14 senior NASA flight controllers who were chosen on the basis of having had substantial experience working with international partners. Data were content analyzed using an iterative process with multiple coders and consensus meetings to resolve discrepancies. To further explore the meaning of the interview findings, we also conducted some new analyses of data from a previous questionnaire study of Russian and American ISS mission control personnel. The interview data showed that respondents had substantial consensus on several leadership and cultural challenges and on key strategies for dealing with them, and they offered a wide range of specific tactics for implementing these strategies. Surprisingly few respondents offered strategies for addressing the challenge of working with team members whose native language is not American English. The questionnaire data showed that Americans think it is more important than Russians that mission control personnel speak the same dialect of one shared common language. Although specific to the ISS program, our results are consistent with recent management, cultural, and aerospace research. We aim to use our results to improve training for current and future ISS flight controllers.

Identification of the first recurrent PAR1 deletion in Léri-Weill dyschondrosteosis and idiopathic short stature reveals the presence of a novel SHOX enhancer.

PubMed

Benito-Sanz, Sara; Royo, Jose Luis; Barroso, Eva; Paumard-Hernández, Beatriz; Barreda-Bonis, Ana C; Liu, Pengfei; Gracía, Ricardo; Lupski, James R; Campos-Barros, Ángel; Gómez-Skarmeta, José Luis; Heath, Karen Elise

2012-07-01

SHOX, located in the pseudoautosomal region 1 (PAR1) of the sexual chromosomes, encodes a transcription factor implicated in human growth. Defects in SHOX or its enhancers have been observed in ∼60% of Leri-Weill dyschondrosteosis (LWD) patients, a skeletal dysplasia characterised by short stature and/or the characteristic Madelung deformity, and in 2-5% of idiopathic short stature (ISS). To identify the molecular defect in the remaining genetically undiagnosed LWD and ISS patients, this study screened previously unanalysed PAR1 regions in 124 LWD and 576 ISS probands. PAR1 screening was undertaken by multiplex ligation dependent probe amplification (MLPA). Copy number alterations were subsequently confirmed and delimited by locus-specific custom-designed MLPA, array comparative genomic hybridisation (CGH) and breakpoint junction PCR/sequencing. A recurrent PAR1 deletion downstream of SHOX spanning 47543 bp with identical breakpoints was identified in 19 LWD (15.3%) and 11 ISS (1.9%) probands, from 30 unrelated families. Eight evolutionarily conserved regions (ECRs 1-8) identified within the deleted sequence were evaluated for SHOX regulatory activity by means of chromosome conformation capture (3C) in chicken embryo limbs and luciferase reporter assays in human U2OS osteosarcoma cells. The 3C assay indicated potential SHOX regulatory activity by ECR1, which was subsequently confirmed to act as a SHOX enhancer, operating in an orientation and position independent manner, in human U2OS cells. This study has identified the first recurrent PAR1 deletion in LWD and ISS, which results in the loss of a previously uncharacterised SHOX enhancer. The loss of this enhancer may decrease SHOX transcription, resulting in LWD or ISS due to SHOX haploinsufficiency.

[Cost analysis of emergency room patients in the German diagnosis-related groups system. A practice relevant depiction subject to clinical parameters].

PubMed

Garving, C; Santosa, D; Bley, C; Pape, H-C

2014-08-01

Since the implementation of the diagnosis-related system there has been a continuous lack of finances in the treatment of multiple injured patients. The current investigation summarizes consecutive patients from a level I trauma centre and tests the hypothesis that an injury severity score (ISS) based reimbursement would be an improvement in the cost-effectiveness of this patient population. The study is based on multiple injured patients admitted to the emergency department in 2009. The ISS, intensive care unit (ICU) stay and cost data were recorded for every patient and two subgroups were formed: group I ISS < 16 and group II ISS ≥ 16. A total of 442 patients with an average age of 40.5 ± 9.1 years (ISS 12) were included. The average amount of coverage during an average length of stay of 13.15 ± 6.3 was -2,752 per patient. Patients in group I (n = 296, ISS 6.3) showed a value of -1,163 with an average length of stay of 8 ± 4.6 days. In group II (n = 146, ISS 23.6) the average amount of coverage was -5,973 during an average hospital stay of 23 ± 8.7 days. Improvements have been made with the recent adjustment of the reimbursement within the last year. Nevertheless, several factors identified in this study require additional adjustment: the ISS, the requirement of blood transfusion and the presence of additional chest trauma should be weighted in the calculation of reimbursement.

Systematic investigation of ion suppression and enhancement effects of fourteen stable-isotope-labeled internal standards by their native analogues using atmospheric-pressure chemical ionization and electrospray ionization and the relevance for multi-analyte liquid chromatographic/mass spectrometric procedures.

PubMed

Remane, Daniela; Wissenbach, Dirk K; Meyer, Markus R; Maurer, Hans H

2010-04-15

In clinical and forensic toxicology, multi-analyte procedures are very useful to quantify drugs and poisons of different classes in one run. For liquid chromatographic/tandem mass spectrometric (LC/MS/MS) multi-analyte procedures, often only a limited number of stable-isotope-labeled internal standards (SIL-ISs) are available. If an SIL-IS is used for quantification of other analytes, it must be excluded that the co-eluting native analyte influences its ionization. Therefore, the effect of ion suppression and enhancement of fourteen SIL-ISs caused by their native analogues has been studied. It could be shown that the native analyte concentration influenced the extent of ion suppression and enhancement effects leading to more suppression with increasing analyte concentration especially when electrospray ionization (ESI) was used. Using atmospheric-pressure chemical ionization (APCI), methanolic solution showed mainly enhancement effects, whereas no ion suppression and enhancement effect, with one exception, occurred when plasma extracts were used under these conditions. Such differences were not observed using ESI. With ESI, eleven SIL-ISs showed relevant suppression effects, but only one analyte showed suppression effects when APCI was used. The presented study showed that ion suppression and enhancement tests using matrix-based samples of different sources are essential for the selection of ISs, particularly if used for several analytes to avoid incorrect quantification. In conclusion, only SIL-ISs should be selected for which no suppression and enhancement effects can be observed. If not enough ISs are free of ionization interferences, a different ionization technique should be considered. 2010 John Wiley & Sons, Ltd.

Treating floodplain lakes of large rivers as study units for variables that vary within lakes; an evaluation using chlorophyll a and inorganic suspended solids data from floodplain lakes of the Upper Mississippi River

USGS Publications Warehouse

Gray, B.R.; Rogala, J.R.; Houser, J.N.

2013-01-01

Contiguous floodplain lakes ('lakes') have historically been used as study units for comparative studies of limnological variables that vary within lakes. The hierarchical nature of these studies implies that study variables may be correlated within lakes and that covariate associations may differ not only among lakes but also by spatial scale. We evaluated the utility of treating lakes as study units for limnological variables that vary within lakes based on the criteria of important levels of among-lake variation in study variables and the observation of covariate associations that vary among lakes. These concerns were selected, respectively, to ensure that lake signatures were distinguishable from within-lake variation and that lake-scale effects on covariate associations might provide inferences not available by ignoring those effects. Study data represented chlorophyll a (CHL) and inorganic suspended solids (ISS) data from lakes within three reaches of the Upper Mississippi River. Sampling occurred in summer from 1993 through 2005 (except 2003); numbers of lakes per reach varied from 7 to 19, and median lake area varied from 53 to 101 ha. CHL and ISS levels were modelled linearly, with lake, year and lake x year effects treated as random. For all reaches, the proportions of variation in CHL and ISS attributable to differences among lakes (including lake and lake x year effects) were substantial (range: 18%-73%). Finally, among-lake variation in CHL and ISS was strongly associated with covariates and covariate effects that varied by lakes or lake-years (including with vegetation levels and, for CHL, log(ISS)). These findings demonstrate the utility of treating floodplain lakes as study units for the study of limnological variables and the importance of addressing hierarchy within study designs when making inferences from data collected within floodplain lakes.

Thirsk inserts samples into MELFI in the JPM

NASA Image and Video Library

2009-06-07

ISS020-E-007156 (7 June 2009) --- Canadian Space Agency astronaut Robert Thirsk, Expedition 20 flight engineer, performs an insertion of urine samples into the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) as part of the Nutritional Status Assessment (NUTRITION) study in the Japanese Kibo laboratory of the International Space Station.

NUTRITION w/Repository into MELFI

NASA Image and Video Library

2009-07-30

ISS020-E-026348 (30 July 2009) --- Astronaut Tim Kopra, Expedition 20 flight engineer, smiles for the camera as he completes the task of placing samples taken for the Nutritional Status Assessment (NUTRITION) w/Repository study into the Minus Eighty Degree Laboratory Freezer for ISS (MELFI) in the Kibo laboratory of the International Space Station.

High School Completion of In-School Suspension Students.

ERIC Educational Resources Information Center

Johnston, Joanne S.

1989-01-01

Examines the high school completion rate of students in the class of 1988 assigned to an inschool suspension (ISS) program at some time during their high school career. Clearly, ISS students are high risks for school completion, as shown by this study's less than 50 percent completion rate. Nonetheless, such programs are essential. (MLH)

Using the International Space Station (ISS) Oxygen Generation Assembly (OGA) Is Not Feasible for Mars Transit

NASA Technical Reports Server (NTRS)

Jones, Harry W.

2016-01-01

A review of two papers on improving the International Space Station (ISS) Oxygen Generation Assembly (OGA) shows that it would not save substantial mass on a Mars transit. The ISS OGA requires redesign for satisfactory operation, even for the ISS. The planned improvements of the OGA for ISS would not be sufficient to make it suitable for Mars, because Mars transit life support has significantly different requirements than ISS. The OGA for Mars should have lower mass, better reliability and maintainability, greater safety, radiation hardening, and capability for quiescent operation. NASA's methodical, disciplined systems engineering process should be used to develop the appropriate system.

ISS Microgravity Environment

NASA Technical Reports Server (NTRS)

Laible, Michael R.

2011-01-01

The Microgravity performance assessment of the International Space Station (ISS) is comprised of a quasi-steady, structural dynamic and a vibro-acoustic analysis of the ISS assembly-complete vehicle configuration. The Boeing Houston (BHOU) Loads and Dynamics Team is responsible to verify compliance with the ISS System Specification (SSP 41000) and USOS Segment (SSP 41162) microgravity requirements. To verify the ISS environment, a series of accelerometers are on-board to monitor the current environment. This paper summarizes the results of the analysis that was performed for the Verification Analysis Cycle (VAC)-Assembly Complete (AC) and compares it to on-orbit acceleration values currently being reported. The analysis will include the predicted maximum and average environment on-board ISS during multiple activity scenarios

International Space Station (ISS) Orbital Replaceable Unit (ORU) Wet Storage Risk Assessment

NASA Technical Reports Server (NTRS)

Squire, Michael D.; Rotter, Henry A.; Lee, Jason; Packham, Nigel; Brady, Timothy K.; Kelly, Robert; Ott, C. Mark

2014-01-01

The International Space Station (ISS) Program requested the NASA Engineering and Safety Center (NESC) to evaluate the risks posed by the practice of long-term wet storage of ISS Environmental Control and Life Support (ECLS) regeneration system orbital replacement units (ORUs). The ISS ECLS regeneration system removes water from urine and humidity condensate and converts it into potable water and oxygen. A total of 29 ORUs are in the ECLS system, each designed to be replaced by the ISS crew when necessary. The NESC assembled a team to review the ISS ECLS regeneration system and evaluate the potential for biofouling and corrosion. This document contains the outcome of the evaluation.

Conducting On-orbit Gene Expression Analysis on ISS: WetLab-2

NASA Technical Reports Server (NTRS)

Parra, Macarena; Almeida, Eduardo; Boone, Travis; Jung, Jimmy; Lera, Matthew P.; Ricco, Antonio; Souza, Kenneth; Wu, Diana; Richey, C. Scott

2013-01-01

WetLab-2 will enable expanded genomic research on orbit by developing tools that support in situ sample collection, processing, and analysis on ISS. This capability will reduce the time-to-results for investigators and define new pathways for discovery on the ISS National Lab. The primary objective is to develop a research platform on ISS that will facilitate real-time quantitative gene expression analysis of biological samples collected on orbit. WetLab-2 will be capable of processing multiple sample types ranging from microbial cultures to animal tissues dissected on orbit. WetLab-2 will significantly expand the analytical capabilities onboard ISS and enhance science return from ISS.

Numerical Study of Ammonia Leak and Dispersion in the International Space Station

NASA Technical Reports Server (NTRS)

Son, Chang H.

2011-01-01

Management of off-nominal situations on-board the International Space Station (ISS) is important to its continuous operation. One situation of concern is an accidental release of a chemical into the ISS atmosphere. In particular, introduction of ammonia into the cabin atmosphere can occur via the interface heat exchangers (IFHX) between the external thermal control system containing ammonia and internal thermal control system that uses water as a coolant to remove heat from ISS subsystems. Breach of the water/ammonia barrier of the IFHX can lead to a catastrophic rupture. Once the liquid water/ammonia mixture exits the ITCS, it instantly vaporizes and mixes with the U.S. Laboratory cabin atmosphere that results in rapid contamination of the cabin. The goal of the study is to assess the amount of ammonia in the Russian Segment by the time the crew is able to isolate the U.S. Segment. A Computational Fluid Dynamics (CFD) model for an accurate prediction of airflow and ammonia transport in the frozen flow field within the assembly complete ISS cabin was developed. The localized effects of ammonia dispersion are examined and discussed.

Comparison of ISS, NISS, and RTS score as predictor of mortality in pediatric fall.

PubMed

Soni, Kapil Dev; Mahindrakar, Santosh; Gupta, Amit; Kumar, Subodh; Sagar, Sushma; Jhakal, Ashish

2017-01-01

Studies to identify an ideal trauma score tool representing prediction of outcomes of the pediatric fall patient remains elusive. Our study was undertaken to identify better predictor of mortality in the pediatric fall patients. Data was retrieved from prospectively maintained trauma registry project at level 1 trauma center developed as part of Multicentric Project-Towards Improving Trauma Care Outcomes (TITCO) in India. Single center data retrieved from a prospectively maintained trauma registry at a level 1 trauma center, New Delhi, for a period ranging from 1 October 2013 to 17 February 2015 was evaluated. Standard anatomic scores Injury Severity Score (ISS) and New Injury Severity Score (NISS) were compared with physiologic score Revised Trauma Score (RTS) using receiver operating curve (ROC). Heart rate and RTS had a statistical difference among the survivors to nonsurvivors. ISS, NISS, and RTS were having 50, 50, and 86% of area under the curve on ROCs, and RTS was statistically significant among them. Physiologically based trauma score systems (RTS) are much better predictors of inhospital mortality in comparison to anatomical based scoring systems (ISS and NISS) for unintentional pediatric falls.

SHOX gene and conserved noncoding element deletions/duplications in Colombian patients with idiopathic short stature.

PubMed

Sandoval, Gloria Tatiana Vinasco; Jaimes, Giovanna Carola; Barrios, Mauricio Coll; Cespedes, Camila; Velasco, Harvy Mauricio

2014-03-01

SHOX gene mutations or haploinsufficiency cause a wide range of phenotypes such as Leri Weill dyschondrosteosis (LWD), Turner syndrome, and disproportionate short stature (DSS). However, this gene has also been found to be mutated in cases of idiopathic short stature (ISS) with a 3-15% frequency. In this study, the multiplex ligation-dependent probe amplification (MLPA) technique was employed to determine the frequency of SHOX gene mutations and their conserved noncoding elements (CNE) in Colombian patients with ISS. Patients were referred from different centers around the county. From a sample of 62 patients, 8.1% deletions and insertions in the intragenic regions and in the CNE were found. This result is similar to others published in other countries. Moreover, an isolated case of CNE 9 duplication and a new intron 6b deletion in another patient, associated with ISS, are described. This is one of the first studies of a Latin American population in which deletions/duplications of the SHOX gene and its CNE are examined in patients with ISS.

SHOX gene and conserved noncoding element deletions/duplications in Colombian patients with idiopathic short stature

PubMed Central

Sandoval, Gloria Tatiana Vinasco; Jaimes, Giovanna Carola; Barrios, Mauricio Coll; Cespedes, Camila; Velasco, Harvy Mauricio

2014-01-01

SHOX gene mutations or haploinsufficiency cause a wide range of phenotypes such as Leri Weill dyschondrosteosis (LWD), Turner syndrome, and disproportionate short stature (DSS). However, this gene has also been found to be mutated in cases of idiopathic short stature (ISS) with a 3–15% frequency. In this study, the multiplex ligation-dependent probe amplification (MLPA) technique was employed to determine the frequency of SHOX gene mutations and their conserved noncoding elements (CNE) in Colombian patients with ISS. Patients were referred from different centers around the county. From a sample of 62 patients, 8.1% deletions and insertions in the intragenic regions and in the CNE were found. This result is similar to others published in other countries. Moreover, an isolated case of CNE 9 duplication and a new intron 6b deletion in another patient, associated with ISS, are described. This is one of the first studies of a Latin American population in which deletions/duplications of the SHOX gene and its CNE are examined in patients with ISS. PMID:24689071

ISS Plasma Interaction: Measurements and Modeling

NASA Technical Reports Server (NTRS)

Barsamian, H.; Mikatarian, R.; Alred, J.; Minow, J.; Koontz, S.

2004-01-01

Ionospheric plasma interaction effects on the International Space Station are discussed in the following paper. The large structure and high voltage arrays of the ISS represent a complex system interacting with LEO plasma. Discharge current measurements made by the Plasma Contactor Units and potential measurements made by the Floating Potential Probe delineate charging and magnetic induction effects on the ISS. Based on theoretical and physical understanding of the interaction phenomena, a model of ISS plasma interaction has been developed. The model includes magnetic induction effects, interaction of the high voltage solar arrays with ionospheric plasma, and accounts for other conductive areas on the ISS. Based on these phenomena, the Plasma Interaction Model has been developed. Limited verification of the model has been performed by comparison of Floating Potential Probe measurement data to simulations. The ISS plasma interaction model will be further tested and verified as measurements from the Floating Potential Measurement Unit become available, and construction of the ISS continues.

Automated Derivation of Complex System Constraints from User Requirements

NASA Technical Reports Server (NTRS)

Muery, Kim; Foshee, Mark; Marsh, Angela

2006-01-01

International Space Station (ISS) payload developers submit their payload science requirements for the development of on-board execution timelines. The ISS systems required to execute the payload science operations must be represented as constraints for the execution timeline. Payload developers use a software application, User Requirements Collection (URC), to submit their requirements by selecting a simplified representation of ISS system constraints. To fully represent the complex ISS systems, the constraints require a level of detail that is beyond the insight of the payload developer. To provide the complex representation of the ISS system constraints, HOSC operations personnel, specifically the Payload Activity Requirements Coordinators (PARC), manually translate the payload developers simplified constraints into detailed ISS system constraints used for scheduling the payload activities in the Consolidated Planning System (CPS). This paper describes the implementation for a software application, User Requirements Integration (URI), developed to automate the manual ISS constraint translation process.

International Space Station (ISS)

NASA Image and Video Library

2005-06-09

The STS-121 patch depicts the Space Shuttle docked with the International Space Station (ISS) in the foreground, overlaying the astronaut symbol with three gold columns and a gold star. The ISS is shown in the configuration that it was during the STS-121 mission. The background shows the nighttime Earth with a dawn breaking over the horizon. STS-121, ISS mission ULF1.1, was the final Shuttle Return to Flight test mission. This utilization and logistics flight delivered a multipurpose logistics module (MPLM) to the ISS with several thousand pounds of new supplies and experiments. In addition, some new orbital replacement units (ORUs) were delivered and stowed externally on the ISS on a special pallet. These ORUs are spares for critical machinery located on the outside of the ISS. During this mission the crew also carried out testing of Shuttle inspection and repair hardware, as well as evaluated operational techniques and concepts for conducting on-orbit inspection and repair.

[Time-evolution study on the cation exchange in the process of reinforcing slip soil by laser-induced breakdown spectroscopy].

PubMed

Liu, Lu-Wen; Zeng, Wei-Li; Zhu, Xiang-Fei; Wu, Jin-Quan; Lin, Zhao-Xiang

2014-03-01

In the present paper, the time evolution study on slip soils treated by different proportions of ionic soil stabilizer (ISS) water solution was conducted by the LIBS system and the relationship between the cation exchange and such engineering properties of reinforcing soil as plasticity index, cohesive force and coefficient of compressibility were analyzed. The results showed that the cation exchange velocity of the proportion of 1:200 ISS reinforcing soil is the fastest among the three proportions (1:100, 1:200 and 1:300) and the modification effect of engineering performance index is quite obvious. These studies provide an experimental basis for the ISS applied to curing project, and monitoring geotechnical engineering performance by LIBS technology also provides a new way of thinking for the curing project monitoring.

[Patient readmission for surgical site infection: integrative review].

PubMed

Machado, Lilian; Turrini, Ruth N T; Siqueira, Ana L

2013-02-01

Surgical site infections (SSI) represent an inherent risk after surgical procedures associated both to the surgical procedure and to the patient clinical conditions. To analyze in an integrative review the studies related to patient readmission due to SSI. The review was carried out by LILACS, CINHAL, MEDLINE and COCHRANE databases and articles published from 1966 to 2010 were selected. It was analyzed 13 studies classified as transversal (7), cohort (4) and longitudinal (2). Few studies analyzed only the readmissions related to the SSI. Time to define the readmission ranged from 28 to 90 days after surgery and studies related to orthopedic procedures were more frequent. The ISS readmission rates were lower than 5%. The main aetiological agents isolated from ISS were Staphylococcus aureus and coagulase-negative staphylococci. Monitoring readmissions due to SSI could contribute to dimension the occurrence of ISS post-discharge, once about half of the SSI post-discharge was diagnosed at the readmission moment.

On Crosslinguistic Variations in Imperfective Aspect: The Case of L2 Korean

ERIC Educational Resources Information Center

Lee, EunHee; Kim, Hae-Young

2007-01-01

This article examines the acquisition of Korean imperfective markers, the progressive "-ko iss-" and the resultative "-a iss-," with a view to understanding how tense/aspect morphology expands beyond prototype associations with inherent aspects of the verbs. We hypothesized that "-a iss-" will develop later than "-ko iss-," but that the…

Pettit uses a Grab Sample Container in the FGB during Expedition Six

NASA Image and Video Library

2003-01-22

ISS006-E-20835 (22 January 2003) --- Astronaut Donald R. Pettit, Expedition 6 NASA ISS science officer, holds a Grab Sample Container (GSC) in the functional cargo block (FGB), or Zarya, on the International Space Station (ISS). GSC is used for collecting air samples as part of ISS environmental monitoring.

Expedition 11 Science Officer and Flight Engineer John Phillips in Node 1/Unity

NASA Image and Video Library

2005-04-17

ISS011-E-05161 (17 April 2005) --- Astronaut John L. Phillips, Expedition 11 NASA ISS science officer and flight engineer, uses the ISS wet/dry vacuum cleaner assembly to catch floating debris from the top of a food can in the Unity node of the International Space Station (ISS).

Pettit uses a Grab Sample Container in the U.S. Laboratory during Expedition Six

NASA Image and Video Library

2003-01-22

ISS006-E-20834 (22 January 2003) --- Astronaut Donald R. Pettit, Expedition Six NASA ISS science officer, holds a Grab Sample Container (GSC) in the Destiny laboratory on the International Space Station (ISS). GSC is used for collecting air samples as part of ISS environmental monitoring.

SAGEIII-ISS L2 Lunar Data Release

Atmospheric Science Data Center

2018-01-12

... Space Station (SAGE III-ISS) Science Team and the NASA Langley Atmospheric Science Data Center (ASDC), announces the public ... Lunar Event Species Profiles (HDF-EOS) V5 (g3bssp)      doi: 10.5067/ISS/SAGEIII/LUNAR_HDF4_L2-V5.0 SAGE III/ISS L2 Lunar Event ...

Thermal Design and Analysis of an ISS Science Payload - SAGE III on ISS

NASA Technical Reports Server (NTRS)

Liles, Kaitlin, A. K.; Amundsen, Ruth M.; Davis, Warren T.; Carrillo, Laurie Y.

2017-01-01

The Stratospheric Aerosol and Gas Experiment III (SAGE III) instrument is the fifth in a series of instruments developed for monitoring aerosols and gaseous constituents in the stratosphere and troposphere. SAGE III will be launched in the SpaceX Dragon vehicle in 2017 and mounted to an external stowage platform on the International Space Station (ISS) to begin its three-year mission. The SAGE III thermal team at NASA Langley Research Center (LaRC) worked with ISS thermal engineers to ensure that SAGE III, as an ISS payload, would meet requirements specific to ISS and the Dragon vehicle. This document presents an overview of the SAGE III thermal design and analysis efforts, focusing on aspects that are relevant for future ISS payload developers. This includes development of detailed and reduced Thermal Desktop (TD) models integrated with the ISS and launch vehicle models, definition of analysis cases necessary to verify thermal requirements considering all mission phases from launch through installation and operation on-orbit, and challenges associated with thermal hardware selection including heaters, multi-layer insulation (MLI) blankets, and thermal tapes.

Derivation of Failure Rates and Probability of Failures for the International Space Station Probabilistic Risk Assessment Study

NASA Technical Reports Server (NTRS)

Vitali, Roberto; Lutomski, Michael G.

2004-01-01

National Aeronautics and Space Administration s (NASA) International Space Station (ISS) Program uses Probabilistic Risk Assessment (PRA) as part of its Continuous Risk Management Process. It is used as a decision and management support tool to not only quantify risk for specific conditions, but more importantly comparing different operational and management options to determine the lowest risk option and provide rationale for management decisions. This paper presents the derivation of the probability distributions used to quantify the failure rates and the probability of failures of the basic events employed in the PRA model of the ISS. The paper will show how a Bayesian approach was used with different sources of data including the actual ISS on orbit failures to enhance the confidence in results of the PRA. As time progresses and more meaningful data is gathered from on orbit failures, an increasingly accurate failure rate probability distribution for the basic events of the ISS PRA model can be obtained. The ISS PRA has been developed by mapping the ISS critical systems such as propulsion, thermal control, or power generation into event sequences diagrams and fault trees. The lowest level of indenture of the fault trees was the orbital replacement units (ORU). The ORU level was chosen consistently with the level of statistically meaningful data that could be obtained from the aerospace industry and from the experts in the field. For example, data was gathered for the solenoid valves present in the propulsion system of the ISS. However valves themselves are composed of parts and the individual failure of these parts was not accounted for in the PRA model. In other words the failure of a spring within a valve was considered a failure of the valve itself.

Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice.

PubMed

Haughey, Heather M; Kaiser, Alan L; Johnson, Thomas E; Bennett, Beth; Sikela, James M; Zahniser, Nancy R

2005-10-01

Altered noradrenergic neurotransmission is associated with depression and may contribute to drug abuse and alcoholism. Differential initial sensitivity to ethanol is an important predictor of risk for future alcoholism, making the inbred long-sleep (ILS) and inbred short-sleep (ISS) mice a useful model for identifying genes that may contribute to alcoholism. In this study, molecular biological, neurochemical, and behavioral approaches were used to test the hypothesis that the norepinephrine transporter (NET) contributes to the differences in ethanol-induced loss of righting reflex (LORR) in ILS and ISS mice. We used these mice to investigate the NET as a candidate gene contributing to this phenotype. The ILS and ISS mice carry different DNA haplotypes for NET, showing eight silent differences between allelic coding regions. Only the ILS haplotype is found in other mouse strains thus far sequenced. Brain regional analyses revealed that ILS mice have 30 to 50% lower [3H]NE uptake, NET binding, and NET mRNA levels than ISS mice. Maximal [3H]NE uptake and NET number were reduced, with no change in affinity, in the ILS mice. These neurobiological changes were associated with significant influences on the behavioral phenotype of these mice, as demonstrated by (1) a differential response in the duration of ethanol-induced LORR in ILS and ISS mice pretreated with a NET inhibitor and (2) increased ethanol-induced LORR in LXS recombinant inbred (RI) strains, homozygous for ILS in the NET chromosomal region (44-47 cM), compared with ISS homozygous strains. This is the first report to suggest that the NET gene is one of many possible genetic factors influencing ethanol sensitivity in ILS, ISS, and LXS RI mouse strains.

Usefulness of the abbreviated injury score and the injury severity score in comparison to the Glasgow Coma Scale in predicting outcome after traumatic brain injury.

PubMed

Foreman, Brandon P; Caesar, R Ruth; Parks, Jennifer; Madden, Christopher; Gentilello, Larry M; Shafi, Shahid; Carlile, Mary C; Harper, Caryn R; Diaz-Arrastia, Ramon R

2007-04-01

Assessment of injury severity is important in the management of patients with brain trauma. We aimed to analyze the usefulness of the head abbreviated injury score (AIS), the injury severity score (ISS), and the Glasgow Coma Scale (GCS) as measures of injury severity and predictors of outcome after traumatic brain injury (TBI). Data were prospectively collected from 410 patients with TBI. AIS, ISS, and GCS were recorded at admission. Subjects' outcomes after TBI were measured using the Glasgow Outcome Scale (GOS-E) at 12 months postinjury. Uni- and multivariate analyses were performed. Outcome information was obtained from 270 patients (66%). ISS was the best predictor of GOS-E (rs = -0.341, p < 0.001), followed by GCS score (rs = 0.227, p < 0.001), and head AIS (rs = -0.222, p < 0.001). When considered in combination, GCS score and ISS modestly improved the correlation with GOS-E (R = 0.335, p < 0.001). The combination of GCS score and head AIS had a similar effect (R = 0.275, p < 0.001). Correlations were stronger from patients 8). GCS score, AIS, and ISS are weakly correlated with 12-month outcome. However, anatomic measures modestly outperform GCS as predictors of GOS-E. The combination of GCS and AIS/ISS correlate with outcome better than do any of the three measures alone. Results support the addition of anatomic measures such as AIS and ISS in clinical studies of TBI. Additionally, most of the variance in outcome is not accounted for by currently available measures of injury severity.

Impact of remote monitoring on reducing the burden of inappropriate shocks related to implantable cardioverter-defibrillator lead fractures: insights from a French single-centre registry.

PubMed

Souissi, Zouheir; Guédon-Moreau, Laurence; Boulé, Stéphane; Kouakam, Claude; Finat, Loïc; Marquié, Christelle; Brigadeau, François; Wissocque, Ludivine; Mouton, Stéphanie; Montaigne, David; Klug, Didier; Kacet, Salem; Lacroix, Dominique

2016-06-01

Lead fractures in implantable cardioverter-defibrillator (ICD) patients may cause inappropriate shocks (ISs). An early diagnosis is essential to prevent adverse clinical events. Implantable cardioverter-defibrillator remote monitoring (RM) permits prompt detection of lead fracture. Limited data define the impact of RM on ISs specifically related to lead fracture. We sought to compare the number of ISs related to lead fracture in patients with vs. without RM follow-up. We checked the registry of our institution and collected, between July 2007 and June 2014, 115 cases of right ventricular lead fractures. All relevant data were documented from patients' files, device-interrogation printouts and electronic records, and remote transmissions databases when applicable. We assessed the ISs that were related to lead fracture. The first study endpoint was the number of ISs per shocked patient. Among the 82 patients with conventional follow-up (CFU) and the 33 patients with RM, a first IS occurred to 32.9% (n = 27) and 30.3% (n = 10, P = 0.83) of the patients, respectively. Shocked patients in the RM group underwent significantly fewer ISs with a mean of 6 ± 2 shocks per patient [median of 3.5 shocks (2-8)] than those in the CFU group with a mean of 18 ± 5 shocks per patient [median of 10 shocks (5-22), P = 0.03]. Remote monitoring helps to reduce the burden of ISs related to ICD lead fractures. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

Bubble-detector measurements of neutron radiation in the international space station: ISS-34 to ISS-37

PubMed Central

Smith, M. B.; Khulapko, S.; Andrews, H. R.; Arkhangelsky, V.; Ing, H.; Koslowksy, M. R.; Lewis, B. J.; Machrafi, R.; Nikolaev, I.; Shurshakov, V.

2016-01-01

Bubble detectors have been used to characterise the neutron dose and energy spectrum in several modules of the International Space Station (ISS) as part of an ongoing radiation survey. A series of experiments was performed during the ISS-34, ISS-35, ISS-36 and ISS-37 missions between December 2012 and October 2013. The Radi-N2 experiment, a repeat of the 2009 Radi-N investigation, included measurements in four modules of the US orbital segment: Columbus, the Japanese experiment module, the US laboratory and Node 2. The Radi-N2 dose and spectral measurements are not significantly different from the Radi-N results collected in the same ISS locations, despite the large difference in solar activity between 2009 and 2013. Parallel experiments using a second set of detectors in the Russian segment of the ISS included the first characterisation of the neutron spectrum inside the tissue-equivalent Matroshka-R phantom. These data suggest that the dose inside the phantom is ∼70 % of the dose at its surface, while the spectrum inside the phantom contains a larger fraction of high-energy neutrons than the spectrum outside the phantom. The phantom results are supported by Monte Carlo simulations that provide good agreement with the empirical data. PMID:25899609

International Space Station as Analog of Interplanetary Transit Vehicle For Biomedical Research

NASA Technical Reports Server (NTRS)

Charles, John B.

2012-01-01

Astronaut missions lasting up to six months aboard the International Space Station (ISS) have much in common with interplanetary flights, especially the outbound, Earth-to-Mars transit portion of a Mars mission. Utilization of ISS and other appropriate platforms to prepare for crewed expeditions to planetary destinations including Mars has been the work of NASA's Human Research Program (HRP) since 2005. HRP is charged specifically to understand and reduced the risks to astronaut health and performance in space exploration missions: everything HRP does and has done is directly related to that responsibility. Two major categories of human research have capitalized on ISS capabilities. The first category centers on the biomedical aspects of long-duration exposure to spaceflight factors, including prolonged weightlessness, radiation exposure, isolation and confinement, and actual risk to life and limb. These studies contribute to astronaut safety, health and efficiency on any long-duration missions, whether in low Earth orbit (LEO) or beyond. Qualitatively, weightlessness is weightlessness, whether in LEO or en route to Mars. The HRP sponsors investigations into losses in muscle and bone integrity, cardiovascular function, sensory-motor capability, immune capacity and psychosocial health, and development and demonstration of appropriate treatments and preventative measures. The second category includes studies that are focused on planetary expeditions beyond LEO. For these, ISS offers a high fidelity analog to investigate the combined effects of spaceflight factors (described above) plus the isolation and autonomy associated with simulated increasing distance from Earth. Investigations address crew cohesion, performance and workload, and mission control performance. The behavioral health and performance and space human factors aspects of planetary missions dominate this category. Work has already begun on a new investigation in this category which will examine the effects of a simulated lag in communications (mimicking that expected in transit to Mars) on astronaut performance aboard ISS. Extension of the current ISS increment duration from six months to nine or even twelve months would provide opportunities for expanded research relevant to long duration missions, albeit at the cost of fewer astronauts as subjects for those investigations. Given the possible limited access to ISS after 2020, if ISS is intended to facilitate future exploration missions, then the in-flight human investigations should focus on those that clearly enable future exploration missions.

Dynamical Conditions of Ice Supersaturation and Ice Nucleation in Convective Systems: A Comparative Analysis Between in Situ Aircraft Observations and WRF Simulations

NASA Technical Reports Server (NTRS)

D’Alessandro, John J.; Diao, Minghui; Wu, Chenglai; Liu, Xiaohong; Chen, Ming; Morrison, Hugh; Eidhammer, Trude; Jensen, Jorgen B.; Bansemer, Aaron; Zondlo, Mark A.;

The New Jettison Policy for the International Space Station

NASA Technical Reports Server (NTRS)

Johnson, Nicholas L.

2006-01-01

During more than seven years of operations by the International Space Station (ISS), approximately three dozen pieces of debris were released and subsequently cataloged by the U.S. Space Surveillance Network (SSN). The individual mass of these objects ranged from less than 1 kg to 70 kg. Although some of these debris were separated from the ISS accidentally, some were intentionally cast-off, especially the larger items. In addition, small operational satellites are candidates for launch from the ISS, such as the TNS-O satellite deployed from ISS in March 2005. Recently an official ISS Jettison Policy was developed to ensure that decisions to deliberately release objects in the future were based upon a complete evaluation of the benefits and risks to the ISS, other resident space objects, and people on the Earth. The policy identifies four categories of items which might be considered for release: (1) items that pose a safety issue for return on-board a visiting vehicle, (2) items that negatively impact ISS utilization, return, or on-orbit stowage manifests, (3) items that represent an EVA timeline savings, and (4) items that are designed for jettison. Some of the principal issues to be addressed during this evaluation process are the potential for the object to recontact the ISS within the first two days after jettison, the potential of the object to breakup prior to reentry, the ability of the SSN to track the object, and the risk to people on Earth from components which might survive reentry. This paper summarizes the history of objects released from ISS, examines the specifics of the ISS jettison policy, and addresses the overall impact of ISS debris on the space environment.

Dynamical conditions of ice supersaturation and ice nucleation in convective systems: A comparative analysis between in situ aircraft observations and WRF simulations

NASA Astrophysics Data System (ADS)

D'Alessandro, John J.; Diao, Minghui; Wu, Chenglai; Liu, Xiaohong; Chen, Ming; Morrison, Hugh; Eidhammer, Trude; Jensen, Jorgen B.; Bansemer, Aaron; Zondlo, Mark A.; DiGangi, Josh P.

2017-03-01

Occurrence frequency and dynamical conditions of ice supersaturation (ISS, where relative humidity with respect to ice (RHi) > 100%) are examined in the upper troposphere around convective activity. Comparisons are conducted between in situ airborne observations and the Weather Research and Forecasting model simulations using four double-moment microphysical schemes at temperatures ≤ -40°C. All four schemes capture both clear-sky and in-cloud ISS conditions. However, the clear-sky (in-cloud) ISS conditions are completely (significantly) limited to the RHi thresholds of the Cooper parameterization. In all of the simulations, ISS occurrence frequencies are higher by 3-4 orders of magnitude at higher updraft speeds (>1 m s-1) than those at the lower updraft speeds when ice water content (IWC) > 0.01 g m-3, while observations show smaller differences up to 1-2 orders of magnitude. The simulated ISS also occurs less frequently at weaker updrafts and downdrafts than observed. These results indicate that the simulations have a greater dependence on stronger updrafts to maintain/generate ISS at higher IWC. At lower IWC (≤0.01 g m-3), simulations unexpectedly show lower ISS frequencies at stronger updrafts. Overall, the Thompson aerosol-aware scheme has the closest magnitudes and frequencies of ISS >20% to the observations, and the modified Morrison has the closest correlations between ISS frequencies and vertical velocity at higher IWC and number density. The Cooper parameterization often generates excessive ice crystals and therefore suppresses the frequency and magnitude of ISS, indicating that it should be initiated at higher ISS (e.g., ≥25%).

The definition of polytrauma: variable interrater versus intrarater agreement--a prospective international study among trauma surgeons.

PubMed

Butcher, Nerida E; Enninghorst, Natalie; Sisak, Krisztian; Balogh, Zsolt J

2013-03-01

The international trauma community has recognized the lack of a validated consensus definition of "polytrauma." We hypothesized that using a subjective definition, trauma surgeons will not have substantial agreement; thus, an objective definition is needed. A prospective observational study was conducted between December 2010 and June 2011 (John Hunter Hospital, Level I trauma center). Inclusion criteria were all trauma call patients with subsequent intensive care unit admission. The study was composed of four stages as follows: (1) four trauma surgeons assessed patients until 24 hours, then coded as either "yes" or "no" for polytrauma, and results compared for agreement; (2) eight trauma surgeons representing the United States, Germany, and the Netherlands graded the same prospectively assessed patients and coded as either "yes" or "no" for polytrauma; (3) 12 months later, the original four trauma surgeons repeated assessment via data sheets to test intrarater variability; and (4) individual subjective definitions were compared with three anatomic scores, namely, (a) Injury Severity Score (ISS) of greater than 15, (b) ISS of greater 17, and (c) Abbreviated Injury Scale (AIS) score of greater than 2 in at least two ISS body regions. A total of 52 trauma patients were included. Results for each stage were as follows: (1) κ score of 0.50, moderate agreement; (2) κ score of 0.41, moderate agreement; (3) Rater 1 had moderate intrarater agreement (κ score, 0.59), while Raters 2, 3, 4 had substantial intrarater agreement (κ scores, 0.75, 0.66, and 0.71, respectively); and (4) none had most agreement with ISS of greater than 15 (κ score, 0.16), while both definitions ISS greater than 17 and Abbreviated Injury Scale (AIS) score of greater than 2 in at least two ISS body regions had on average fair agreement (κ scores, 0.27 and 0.39, respectively). Based on subjective assessments, trauma surgeons do not agree on the definition of polytrauma, with the subjective definition differing both within and across institutions.

Combustion, Complex Fluids, and Fluid Physics Experiments on the ISS

NASA Technical Reports Server (NTRS)

Motil, Brian; Urban, David

2012-01-01

From the very first days of human spaceflight, NASA has been conducting experiments in space to understand the effect of weightlessness on physical and chemically reacting systems. NASA Glenn Research Center (GRC) in Cleveland, Ohio has been at the forefront of this research looking at both fundamental studies in microgravity as well as experiments targeted at reducing the risks to long duration human missions to the moon, Mars, and beyond. In the current International Space Station (ISS) era, we now have an orbiting laboratory that provides the highly desired condition of long-duration microgravity. This allows continuous and interactive research similar to Earth-based laboratories. Because of these capabilities, the ISS is an indispensible laboratory for low gravity research. NASA GRC has been actively involved in developing and operating facilities and experiments on the ISS since the beginning of a permanent human presence on November 2, 2000. As the lead Center both Combustion, Fluid Physics, and Acceleration Measurement GRC has led the successful implementation of an Acceleration Measurement systems, the Combustion Integrated Rack (CIR), the Fluids Integrated Rack (FIR) as well as the continued use of other facilities on the ISS. These facilities have supported combustion experiments in fundamental droplet combustion fire detection fire extinguishment soot phenomena flame liftoff and stability and material flammability. The fluids experiments have studied capillary flow magneto-rheological fluids colloidal systems extensional rheology pool and nucleate boiling phenomena. In this paper, we provide an overview of the experiments conducted on the ISS over the past 12 years. We also provide a look to the future development. Experiments presented in combustion include areas such as droplet combustion, gaseous diffusion flames, solid fuels, premixed flame studies, fire safety, and super critical oxidation processes. In fluid physics, experiments are discussed in multiphase flows, capillary phenomena, and heat pipes. Finally in complex fluids, experiments in rheology and soft condensed materials will be presented.

Practicing for Mars: The International Space Station (ISS) as a Testbed

NASA Technical Reports Server (NTRS)

Korth, David H.

2014-01-01

Allows demonstration and development of exploration capabilities to help accomplish future missions sooner with less risk to crew and mission Characteristics of ISS as a testbed High fidelity human operations platform in LEO: Continuously operating habitat and active laboratory. High fidelity systems. Astronauts as test subjects. Highly experienced ground operations teams. Offers a controlled test environment.: Consequences to systems performance and decision making not offered in ground analogs International participation. Continuously improving system looking for new technology and ideas to improve operations. Technology Demos & Critical Systems Maturation. Human Health and Performance. Operations Simulations and Techniques. Exploration prep testing on ISS has been ongoing since 2012. Number of tests increasing with each ISS expedition. One Year Crew Expedition starting in Spring 2015. ROSCOSMOS and NASA are partnering on the Participating Crew are Mikhail Kornienko and Scott Kelly Majority of testing is an extension of current Human Biomedical Research investigations Plan for extending & expanding upon current operations techniques and tech demo studies ESA 10 Day Mission in Fall 2015 ESA astronaut focus on testing exploration technologies Many more opportunities throughout the life of ISS! 4/24/2014 david.h.korth@nasa.gov 4 Exploration testing

Temporal and spatial characteristics of cone degeneration in RCS rats.

PubMed

Huang, Yan Ming; Yin, Zheng Qin; Liu, Kang; Huo, Shu Jia

2011-03-01

The temporal and spatial characteristics of cone degeneration in the Royal College of Surgeons (RCS) rat were studied to provide information for treatment strategies of retinitis pigmentosa. Nonpigmented dystrophic RCS rats (RCS) and pigmented nondystrophic RCS rats (controls) were used. Cone processes were visualized with peanut agglutinin (PNA). Cone development appears to have been completed by postnatal day 21 (P21) in both the RCS and control rats. Signs of cone degeneration were obvious by P30, with shorter outer segments (OSs) and enlarged inner segments (ISs). At that time, 81.7% of the cones retained stained ISs. The rate of IS density decline was slower in the peripheral, nasal, and superior retina, and only 43.6% of the cones with ISs were present at P45. By P60, PNA-labeled cone ISs were distorted and restricted to the peripheral retina, and by P90, few cone pedicles were detected. Our findings indicate that therapeutic strategies aimed at rescuing cones in the degenerating retina should be applied before P21 and no later than P45 while substantial numbers of cones retain their ISs. Either the middle or peripheral regions of the nasal and superior retina are the best locations for transplantation strategies.

The Situational Awareness Sensor Suite for the ISS (SASSI): A Mission Concept to Investigate ISS Charging and Wake Effects

NASA Technical Reports Server (NTRS)

Krause, L. Habash; Minow, J. I.; Coffey, V. N.; Gilchrist, Brian E.; Hoegy, W. R.

2014-01-01

The complex interaction between the International Space Station (ISS) and the surrounding plasma environment often generates unpredictable environmental situations that affect operations. Examples of affected systems include extravehicular activity (EVA) safety, solar panel efficiency, and scientific instrument integrity. Models and heuristically-derived best practices are well-suited for routine operations, but when it comes to unusual or anomalous events or situations, especially those driven by space weather, there is no substitute for real-time monitoring. Space environment data collected in real-time (or near-real time) can be used operationally for both real-time alarms and data sources in assimilative models to predict environmental conditions important for operational planning. Fixed space weather instruments mounted to the ISS can be used for monitoring the ambient space environment, but knowing whether or not (or to what extent) the ISS affects the measurements themselves requires adequate space situational awareness (SSA) local to the ISS. This paper presents a mission concept to use a suite of plasma instruments mounted at the end of the ISS robotic arm to systematically explore the interaction between the Space Station structure and its surrounding environment. The Situational Awareness Sensor Suite for the ISS (SASSI) would be deployed and operated on the ISS Express Logistics Carrier (ELC) for long-term "survey mode" observations and the Space Station Remote Manipulator System (SSRMS) for short-term "campaign mode" observations. Specific areas of investigation include: 1) ISS frame and surface charging during perturbations of the local ISS space environment, 2) calibration of the ISS Floating Point Measurement Unit (FPMU), 3) long baseline measurements of ambient ionospheric electric potential structures, 4) electromotive force-induced currents within large structures moving through a magnetized plasma, and 5) wake-induced ion waves in both electrostatic (i.e. particles) and electromagnetic modes. SASSI will advance the understanding of plasma-boundary interaction phenomena, demonstrate a suite a sensors acting in concert to provide effective SSA, and validate and/or calibrate existing ISS space environment instruments and models.

iss056e014352

NASA Image and Video Library

2018-06-18

iss056e014352 (June 18, 2018) --- Flight Engineer Alexander Gerst of the European Space Agency (ESA) is in quasi-free-floating configuration for the GRASP study taking place inside Europe's Columbus laboratory module. The ESA-sponsored research is studying how the body adapts to the microgravity environment. GRASP uses virtual reality headsets as a way to understand how important gravity is, compared to the other senses, when reaching for an object.

Factor structure of the happiness-increasing strategies scales (H-ISS): activities and coping strategies in relation to positive and negative affect.

PubMed

Al Nima, Ali; Garcia, Danilo

2015-01-01

Background. Previous research (Tkach & Lyubomirsky, 2006) shows that there are eight general happiness-increasing strategies: social affiliation, partying, mental control, goal pursuit, passive leisure, active leisure, religion, and direct attempts. The present study investigates the factor structure of the happiness-increasing strategies scales (H-ISS) and their relationship to positive and negative affect. Method. The present study used participants' (N = 1,050 and age mean = 34.21 sd = 12.73) responses to the H-ISS in structural equation modeling analyses. Affect was measured using the Positive Affect Negative Affect Schedule. Results. After small modifications we obtained a good model that contains the original eight factors/scales. Moreover, we found that women tend to use social affiliation, mental control, passive leisure, religion, and direct attempts more than men, while men preferred to engage in partying and clubbing more than women. The H-ISS explained significantly the variance of positive affect (R (2) = .41) and the variance of negative affect (R (2) = .27). Conclusions. Our study is an addition to previous research showing that the factor structure of the happiness-increasing strategies is valid and reliable. However, due to the model fitting issues that arise in the present study, we give some suggestions for improving the instrument.

Analysis of ISS Plasma Interaction

NASA Technical Reports Server (NTRS)

Reddell, Brandon; Alred, John; Kramer, Leonard; Mikatarian, Ron; Minow, Joe; Koontz, Steve

2006-01-01

To date, the International Space Station (ISS) has been one of the largest objects flown in lower earth orbit (LEO). The ISS utilizes high voltage solar arrays (160V) that are negatively grounded leading to pressurized elements that can float negatively with respect to the plasma. Because laboratory measurements indicate a dielectric breakdown potential difference of 80V, arcing could occur on the ISS structure. To overcome the possibility of arcing and clamp the potential of the structure, two Plasma Contactor Units (PCUs) were designed, built, and flown. Also a limited amount of measurements of the floating potential for the present ISS configuration were made by a Floating Potential Probe (FPP), indicating a minimum potential of 24 Volts at the measurement location. A predictive tool, the ISS Plasma Interaction Model (PIM) has been developed accounting for the solar array electron collection, solar array mast wire and effective conductive area on the structure. The model has been used for predictions of the present ISS configuration. The conductive area has been inferred based on available floating potential measurements. Analysis of FPP and PCU data indicated distribution of the conductive area along the Russian segment of the ISS structure. A significant input to PIM is the plasma environment. The International Reference Ionosphere (IRI 2001) was initially used to obtain plasma temperature and density values. However, IRI provides mean parameters, leading to difficulties in interpretation of on-orbit data, especially at eclipse exit where maximum charging can occur. This limits our predicative capability. Satellite and Incoherent Scatter Radar (ISR) data of plasma parameters have also been collected. Approximately 130,000 electron temperature (Te) and density (Ne) pairs for typical ISS eclipse exit conditions have been extracted from the reduced Langmuir probe data flown aboard the NASA DE-2 satellite. Additionally, another 18,000 Te and Ne pairs of ISR data from several radar locations around the globe were used to assure consistency of the satellite data. PIM predictions for ISS charging made with this data correlated very well with FPP data, indicating that the general physics of spacecraft charging with high voltage solar arrays have been captured. The predictions also provided the probabilities of occurrences for ISS charging. These probabilities give a numerical measure of the number of times when the ISS will approach or exceed the vehicle plasma hazard conditions for each configuration. In this paper we shall present the interaction mechanisms between the ISS and the surrounding plasma and give an overview of the PIM components. PIM predictions are compared with available data followed by a discussion of the variability of plasma parameters and the conductive area on the ISS. The ISS PIM will be further tested and verified as data from the Floating Potential Measurement Unit become available, and construction of the ISS continues.

Space Environment Factors Affecting the Performance of International Space Station Materials: The First Two Years of Flight Operations

NASA Technical Reports Server (NTRS)

Koontz, Steven L.; Peldey, Michael; Mayeaux, Brian; Milkatarian, Ronald R.; Golden, John; Boeder, paul; Kern, John; Barsamian, Hagop; Alred, John; Soares, Carlos;

iss009e23888

NASA Image and Video Library

2004-09-20

ISS009-E-23888 (20 September 2004) --- Downtown Pittsburgh, with its swollen, muddy rivers, is featured in this image photographed from the International Space Station (ISS). Astronaut Edward M. (Mike) Fincke, Expedition 9 NASA ISS science officer and flight engineer, who is a native of Emsworth, captured this image with a digital camera at 5 p.m. on Monday, September 20, 2004.

Independent Assessment of Instrumentation for ISS On-Orbit NDE. Volume 1

NASA Technical Reports Server (NTRS)

Madaras, Eric I

2013-01-01

International Space Station (ISS) Structural and Mechanical Systems Manager, requested that the NASA Engineering and Safety Center (NESC) provide a quantitative assessment of commercially available nondestructive evaluation (NDE) instruments for potential application to the ISS. This work supports risk mitigation as outlined in the ISS Integrated Risk Management Application (IRMA) Watch Item #4669, which addresses the requirement for structural integrity after an ISS pressure wall leak in the event of a penetration due to micrometeoroid or debris (MMOD) impact. This document contains the outcome of the NESC assessment.

Biomedical Results of ISS Expeditions 1-12

NASA Technical Reports Server (NTRS)

Fogarty, Jennifer; Sams, Clarence F.

2007-01-01

A viewgraph presentation on biomedical data from International Space Station (ISS) Expeditions 1-12 is shown. The topics include: 1) ISS Expeditions 1-12; 2) Biomedical Data; 3) Physiological Assessments; 4) Bone Mineral Density; 5) Bone Mineral Density Recovery; 6) Orthostatic Tolerance; 7) Postural Stability Set of Sensory Organ Test 6; 8) Performance Assessment; 9) Aerobic Capacity of the Astronaut Corps; 10) Pre-flight Aerobic Fitness of ISS Astronauts; 11) In-flight and Post-flight Aerobic Capacity of the Astronaut Corps; and 12) ISS Functional Fitness Expeditions 1-12.

Independent Assessment of Instrumentation for ISS On-Orbit NDE. Volume 2; Appendices

NASA Technical Reports Server (NTRS)

Madaras, Eric I.

2013-01-01

International Space Station (ISS) Structural and Mechanical Systems Manager, requested that the NASA Engineering and Safety Center (NESC) provide a quantitative assessment of commercially available nondestructive evaluation (NDE) instruments for potential application to the ISS. This work supports risk mitigation as outlined in the ISS Integrated Risk Management Application (IRMA) Watch Item #4669, which addresses the requirement for structural integrity after an ISS pressure wall leak in the event of a penetration due to micrometeoroid or debris (MMOD) impact. This document contains the appendices the final report.

Solidifying Small Satellite Access to Orbit via the International Space Station (ISS): Cyclops' Deployment of the Lonestar SmallSat from the ISS

NASA Technical Reports Server (NTRS)

Hershey, Matthew P.; Newswander, Daniel R.; Evernden, Brent A.

2016-01-01

On January 29, 2016, the Space Station Integrated Kinetic Launcher for Orbital Payload Systems (SSIKLOPS), known as "Cyclops" to the International Space Station (ISS) community, deployed Lonestar from the ISS. The deployment of Lonestar, a collaboration between Texas A&M University and the University of Texas at Austin, continued to showcase the simplicity and reliability of the Cyclops deployment system. Cyclops, a NASA-developed, dedicated 10-100 kg class ISS SmallSat deployment system, utilizes the Japanese airlock and robotic systems to seamlessly insert SmallSats into orbit. This paper will illustrate Cyclops' successful deployment of Lonestar from the ISS as well as outline its concept of operations, interfaces, requirements, and processes.

Investigations of a simulated geomagnetic field experienced by the International Space Station on attentional performance.

PubMed

Del Seppia, Cristina; Mezzasalma, Lorena; Messerotti, Mauro; Cordelli, Alessandro; Ghione, Sergio

2009-01-01

We have previously reported that the exposure to an abnormal magnetic field simulating the one encountered by the International Space Station (ISS) orbiting around the Earth may enhance autonomic response to emotional stimuli. Here we report the results of the second part of that study which tested whether this field also affects cognitive functions. Twenty-four volunteers participated in the study, 12 exposed to the natural geomagnetic field and 12 to the magnetic field encountered by ISS. The test protocol consisted of a set of eight tests chosen from a computerized test battery for the assessment of attentional performance. The duration of exposure was 90 min. No effect of exposure to ISS magnetic field was observed on attentional performance. (c) 2008 Wiley-Liss, Inc.

Comparison of the RTS and ISS scores on prediction of survival chances in multiple trauma patients.

PubMed

Akhavan Akbari, G; Mohammadian, A

2012-01-01

Trauma represents the third cause of death after cardio vascular disease and tumors. Also in Iran, road accidents are one of the leading causes of death. Rapid evaluation of trauma severity and prediction of prognosis and mortality rate and probability of survival and rapid treatment of patients is necessary. One of the useful instruments for this is ISS and RTS scoring systems. This study evaluated 70 multi trauma patients in Fatemi trauma center affiliated to Ardabil University of medical science. This study was prospective study populations were 70 trauma patients admitted in Fatemi trauma center. During the II month, and patients data was collected by clinical evaluating of patients and follow up them and arranged as a questionnaire then related findings were evaluated by SPSS software. The average age of patients was 37.6±23.5 years and minimum and maximum age was 1 and 85 years. The most common involved group was 10-19 years (13 men and 1 woman). 81.4% of patients (57 cases were male) and 18.6% were female (13 cases). The most common causes of trauma was car accident with 64.2% frequency (43 cases) and then motorcycle accident with 16.4% frequency (11 cases) and all injured patient due to motorcycle accident compose the age group less than 40 years old. Also car accident had the highest frequency in both gender. Other causes of trauma were fall down with 13.5% frequency (9 cases) and under debris 5.9% (4 cases). Also from 70 studied patients, 67 cases (95.7%) had blunt trauma and 3 cases (4.3%) had penetrating trauma. The most penetrating trauma occurs in ages less than 50 years and was in the range of 30-50 years. The average RTS and ISS was 10.67±1.45 and 18.11±8.64, high and low scores of ISS existed in all age groups but a low score of RTS was highest in the children age group. The average length of ICU stay was 12.14±11.11 days. Overall mortality was 15.7 (11 cases). In this study, by the ISS increasing, the mortality rate also increased. But there is no relation between the mortality rate and RTS ratio. The ISS scoring system performed better than the RTS in predicting of mortality and probability of survival and the length of ICU stay and had high accuracy and can predict patients' outcome better by ISS measuring.

Effect of Intravenous Iron Supplementation on Acute Mountain Sickness: A Preliminary Randomized Controlled Study

PubMed Central

Ren, Xuewen; Zhang, Qiuying; Wang, Hao; Man, Chunyan; Hong, Heng; Chen, Li; Li, Tanshi; Ye, Ping

2015-01-01

Background The aim of this study was to assess the role of intravenous iron supplementation in the prevention of AMS. Material/Methods This was a randomized, double-blinded, placebo-controlled study. Forty-one (n=41) healthy Chinese low-altitude inhabitants living in Beijing, China (altitude of about 50 meters) were randomly assigned into intravenous iron supplementation (ISS group; n=21) and placebo (CON group; n=20) groups. Participants in the ISS group received iron sucrose supplement (200 mg) before flying to Lhasa, China (altitude of 4300 meters). Acute mountain sickness (AMS) severity was assessed with the Lake Louise scoring (LLS) system within 5 days after landing on the plateau (at high altitude). Routine check-ups, clinical biochemistry, and blood tests were performed before departure and 24 h after arrival. Results A total of 38 participants completed the study (ISS group: n=19; CON group: n=19). The rate of subjects with AMS (LLS>3) was lower in the ISS group compared with the CON group, but no significant differences were obtained (P>0.05). There were no differences in patients’ baseline characteristics. The physiological indices were similar in both groups except for serum iron concentrations (19.44±10.02 vs. 85.10±26.78 μmol/L) and transferrin saturation rates (28.20±12.14 vs. 68.34±33.12%), which were significantly higher in the ISS group (P<0.05). Finally, heart rate was identified as a contributing factor of LLS. Conclusions These preliminary findings suggest that intravenous iron supplementation has no significant protective effect on AMS in healthy Chinese low-altitude inhabitants. PMID:26175087

Sex differences associated with intermittent swim stress.

PubMed

Warner, Timothy A; Libman, Matthew K; Wooten, Katherine L; Drugan, Robert C

2013-11-01

Various animal models of depression have been used to seek a greater understanding of stress-related disorders. However, there is still a great need for novel research in this area, as many individuals suffering from depression are resistant to current treatment methods. Women have a higher rate of depression, highlighting the need to investigate mechanisms of sex differences. Therefore, we employed a new animal model to assess symptoms of depression, known as intermittent swim stress (ISS). In this model, the animal experiences 100 trials of cold water swim stress. ISS has already been shown to cause signs of behavioral depression in males, but has yet to be assessed in females. Following ISS exposure, we looked at sex differences in the Morris water maze and forced swim test. The results indicated a spatial learning effect only in the hidden platform task between male and female controls, and stressed and control males. A consistent spatial memory effect was only seen for males exposed to ISS. In the forced swim test, both sexes exposed to ISS exhibited greater immobility, and the same males and females also showed attenuated climbing and swimming, respectively. The sex differences could be due to different neural substrates for males and females. The goal of this study was to provide the first behavioral examination of sex differences following ISS exposure, so the stage of estrous cycle was not assessed for the females. This is a necessary future direction for subsequent experiments. The current article highlights the importance of sex differences in response to stress.

Cardiovascular and Cerebrovascular Control on Return from ISS

NASA Technical Reports Server (NTRS)

Hughson, Richard Lee; Shoemaker, Joel Kevin; Blaber, Andrew Philip; Arbeille, Philippe; Greaves, Danielle Kathleen

2008-01-01

Cardiovascular and Cerebrovascular Control on Return from ISS (CCISS) will study the effects of long-duration spaceflight on crew members' heart functions and their blood vessels that supply the brain. Learning more about the cardiovascular and cerebrovascular systems could lead to specific countermeasures that might better protect future space travelers. This experiment is collaborative with the Canadian Space Agency.

Enterprise: an International Commercial Space Station Option

NASA Astrophysics Data System (ADS)

Lounge, John M.

2002-01-01

In December 1999, the U.S. aerospace company SPACEHAB, Inc., (SPACEHAB) and the Russian aerospace company Rocket and Space Corporation Energia (RSC-Energia), initiated a joint project to establish a commercial venture on the International Space Station (ISS). The approach of this venture is to use private capital to build and attach a commercial habitable module (the "Enterprise Module") to the Russian Segment of the ISS. The module will become an element of the Russian Segment; in return, exclusive rights to use this module for commercial business will be granted to its developers. The Enterprise Module has been designed as a multipurpose module that can provide research accommodation, stowage and crew support services. Recent NASA budget decisions have resulted in the cancellation of NASA's ISS habitation module, a significant delay in its new ISS crew return vehicle, and a mandate to stabilize the ISS program. These constraints limit the ISS crew size to three people and result in very little time available for ISS research support. Since research activity is the primary reason this Space Station is being built, the ISS program must find a way to support a robust international research program as soon as possible. The time is right for a commercial initiative incorporating the Enterprise Module, outfitted with life support systems, and commercially procured Soyuz vehicles to provide the capability to increase ISS crew size to six by the end of 2005.

Bubble-detector measurements of neutron radiation in the international space station: ISS-34 to ISS-37.

PubMed

Smith, M B; Khulapko, S; Andrews, H R; Arkhangelsky, V; Ing, H; Koslowksy, M R; Lewis, B J; Machrafi, R; Nikolaev, I; Shurshakov, V

2016-02-01

Bubble detectors have been used to characterise the neutron dose and energy spectrum in several modules of the International Space Station (ISS) as part of an ongoing radiation survey. A series of experiments was performed during the ISS-34, ISS-35, ISS-36 and ISS-37 missions between December 2012 and October 2013. The Radi-N2 experiment, a repeat of the 2009 Radi-N investigation, included measurements in four modules of the US orbital segment: Columbus, the Japanese experiment module, the US laboratory and Node 2. The Radi-N2 dose and spectral measurements are not significantly different from the Radi-N results collected in the same ISS locations, despite the large difference in solar activity between 2009 and 2013. Parallel experiments using a second set of detectors in the Russian segment of the ISS included the first characterisation of the neutron spectrum inside the tissue-equivalent Matroshka-R phantom. These data suggest that the dose inside the phantom is ∼70% of the dose at its surface, while the spectrum inside the phantom contains a larger fraction of high-energy neutrons than the spectrum outside the phantom. The phantom results are supported by Monte Carlo simulations that provide good agreement with the empirical data. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Expedition 11 Science Officer and Flight Engineer John Phillips in Node 1/ Unity

NASA Image and Video Library

2005-04-17

ISS011-E-05163 (17 April 2005) --- Astronaut John L. Phillips, Expedition 11 NASA ISS science officer and flight engineer, poses for a photo with the ISS wet/dry vacuum cleaner assembly he used to catch floating debris from the top of a food can in the Unity node of the International Space Station (ISS).

Onboard Short Term Plan Viewer

NASA Technical Reports Server (NTRS)

Hall, Tim; LeBlanc, Troy; Ulman, Brian; McDonald, Aaron; Gramm, Paul; Chang, Li-Min; Keerthi, Suman; Kivlovitz, Dov; Hadlock, Jason

2011-01-01

Onboard Short Term Plan Viewer (OSTPV) is a computer program for electronic display of mission plans and timelines, both aboard the International Space Station (ISS) and in ISS ground control stations located in several countries. OSTPV was specifically designed both (1) for use within the limited ISS computing environment and (2) to be compatible with computers used in ground control stations. OSTPV supplants a prior system in which, aboard the ISS, timelines were printed on paper and incorporated into files that also contained other paper documents. Hence, the introduction of OSTPV has both reduced the consumption of resources and saved time in updating plans and timelines. OSTPV accepts, as input, the mission timeline output of a legacy, print-oriented, UNIX-based program called "Consolidated Planning System" and converts the timeline information for display in an interactive, dynamic, Windows Web-based graphical user interface that is used by both the ISS crew and ground control teams in real time. OSTPV enables the ISS crew to electronically indicate execution of timeline steps, launch electronic procedures, and efficiently report to ground control teams on the statuses of ISS activities, all by use of laptop computers aboard the ISS.

Experiments on water detritiation and cryogenic distillation at TLK; Impact on ITER fuel cycle subsystems interfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cristescu, I.; Cristescu, I. R.; Doerr, L.

2008-07-15

The ITER Isotope Separation System (ISS) and Water Detritiation System (WDS) should be integrated in order to reduce potential chronic tritium emissions from the ISS. This is achieved by routing the top (protium) product from the ISS to a feed point near the bottom end of the WDS Liquid Phase Catalytic Exchange (LPCE) column. This provides an additional barrier against ISS emissions and should mitigate the memory effects due to process parameter fluctuations in the ISS. To support the research activities needed to characterize the performances of various components for WDS and ISS processes under various working conditions and configurationsmore » as needed for ITER design, an experimental facility called TRENTA representative of the ITER WDS and ISS protium separation column, has been commissioned and is in operation at TLK The experimental program on TRENTA facility is conducted to provide the necessary design data related to the relevant ITER operating modes. The operation availability and performances of ISS-WDS have impact on ITER fuel cycle subsystems with consequences on the design integration. The preliminary experimental data on TRENTA facility are presented. (authors)« less

Global Precipitation Measurement (GPM) and International Space Station (ISS) Coordination for CubeSat Deployments to Minimize Collision Risk

NASA Technical Reports Server (NTRS)

Pawloski, James H.; Aviles, Jorge; Myers, Ralph; Parris, Joshua; Corley, Bryan; Hehn, Garrett; Pascucci, Joseph

2016-01-01

The Global Precipitation Measurement Mission (GPM) is a joint U.S. and Japan mission to observe global precipitation, extending the Tropical Rainfall Measuring Mission (TRMM), which was launched by H-IIA from Tanegashima in Japan on February 28TH, 2014 directly into its 407km operational orbit. The International Space Station (ISS) is an international human research facility operated jointly by Russia and the USA from NASA's Johnson Space Center (JSC) in Houston Texas. Mission priorities lowered the operating altitude of ISS from 415km to 400km in early 2105, effectively placing both vehicles into the same orbital regime. The ISS has begun a program of deployments of cost effective CubeSats from the ISS that allow testing and validation of new technologies. With a major new asset flying at the same effective altitude as the ISS, CubeSat deployments became a serious threat to GPM and therefore a significant indirect threat to the ISS. This paper describes the specific problem of collision threat to GPM and risk to ISS CubeSat deployment and the process that was implemented to keep both missions safe from collision and maximize their project goals.

Risk Mitigation Approach to Commercial Resupply to the International Space Station

NASA Technical Reports Server (NTRS)

Koons, Diane S.; Schreiber, Craig

2010-01-01

In August 2006, NASA awarded Space Act Agreements (SAAs) for Commercial Orbital Transportation Services (COTS) under the Commercial Crew and Cargo Project Office at Johnson Space Center. One of the goals of the SAAs is to facilitate U.S. private industry demonstration of cargo transportation capabilities, ultimately achieving reliable, cost effective access to low-Earth orbit (LEO). Each COTS provider is required to complete International Space Stations (ISS) Integration activities, which includes meeting the physical and functional interfaces and interface requirements between the ISS and COTS vehicles. These requirements focus on the areas of risk to the ISS during rendezvous and proximity operations, as well as the integration operations while the COTS vehicle is berthed to the ISS. On December 23, 2008, NASA awarded Commercial Resupply Service (CRS) contracts to provide resupply services to the ISS, following the Shuttle retirement. In addition to performing any ISS Integration activities, NASA will be performing independent assessments of the launch vehicle and orbital vehicle to evaluate the readiness of the contractor to deliver NASA cargo safely to the ISS. This paper will address the activities NASA Centers, both JSC and KSC, in the oversight and insight function over commercial visiting vehicles to the ISS.

Expedition 6 Crew Interviews: Don Pettit, Flight Engineer 2/ International Space Station (ISS) Science Officer (SO)

NASA Technical Reports Server (NTRS)

2002-01-01

Expedition 6 member Don Pettit (Flight Engineer 2/ International Space Station (ISS) Science Officer (SO)) is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut and his career path. Pettit, who had been training as a backup crewmember, discusses the importance of training backups for ISS missions. He gives details on the goals and significance of the ISS, regarding experiments in various scientific disciplines such as the life sciences and physical sciences. Pettit also comments on the value of conducting experiments under microgravity. He also gives an overview of the ISS program to date, including the ongoing construction, international aspects, and the routines of ISS crewmembers who inhabit the station for four months at a time. He gives a cursory description of crew transfer procedures that will take place when STS-113 docks with ISS to drop off Pettit and the rest of Expedition 6, and retrieve the Expedition 5 crew.

On-Orbit Propulsion System Performance of ISS Visiting Vehicles

NASA Technical Reports Server (NTRS)

Martin, Mary Regina M.; Swanson, Robert A.; Kamath, Ulhas P.; Hernandez, Francisco J.; Spencer, Victor

2013-01-01

The International Space Station (ISS) represents the culmination of over two decades of unprecedented global human endeavors to conceive, design, build and operate a research laboratory in space. Uninterrupted human presence in space since the inception of the ISS has been made possible by an international fleet of space vehicles facilitating crew rotation, delivery of science experiments and replenishment of propellants and supplies. On-orbit propulsion systems on both ISS and Visiting Vehicles are essential to the continuous operation of the ISS. This paper compares the ISS visiting vehicle propulsion systems by providing an overview of key design drivers, operational considerations and performance characteristics. Despite their differences in design, functionality, and purpose, all visiting vehicles must adhere to a common set of interface requirements along with safety and operational requirements. This paper addresses a wide variety of methods for satisfying these requirements and mitigating credible hazards anticipated during the on-orbit life of propulsion systems, as well as the seamless integration necessary for the continued operation of the ISS.

Organization and Management of the International Space Station (ISS) Multilateral Medical Operations

NASA Technical Reports Server (NTRS)

Duncan, J. M.; Bogomolov, V. V.; Castrucci, F.; Koike, Y.; Comtois, J. M.; Sargsyan, A. E.

2007-01-01

The goal of this work is to review the principles, design, and function of the ISS multilateral medical authority and the medical support system of the ISS Program. Multilateral boards and panels provide operational framework, direct, and supervise the ISS joint medical operational activities. The Integrated Medical Group (IMG) provides front-line medical support of the crews. Results of ongoing activities are reviewed weekly by physician managers. A broader status review is conducted monthly to project the state of crew health and medical support for the following month. All boards, panels, and groups function effectively and without interruptions. Consensus prevails as the primary nature of decisions made by all ISS medical groups, including the ISS medical certification board. The sustained efforts of all partners have resulted in favorable medical outcomes of the initial fourteen long-duration expeditions. The medical support system appears to be mature and ready for further expansion of the roles of all Partners, and for the anticipated increase in the size of ISS crews.

International Space Station in Orbit

NASA Technical Reports Server (NTRS)

2001-01-01

This image of the International Space Station (ISS) was photographed by one of the crewmembers of the STS-105 mission from the Shuttle Orbiter Discovery after deparating from the ISS. The STS-105 mission was the 11th ISS assembly flight and its goals were the rotation of the ISS Expedition Two crew with the Expedition Three crew, and the delivery of supplies utilizing the Italian-built Multipurpose Logistics Module (MPLM) Leonardo. Aboard Leonardo were six resupply stowage racks, four resupply stowage supply platforms, and two new scientific experiment racks, EXPRESS (Expedite the Processing of Experiments to the Space Station) Racks 4 and 5, which added science capabilities to the ISS. Another payload was the Materials International Space Station Experiment (MISSE), which included materials and other types of space exposure experiments mounted on the exterior of the ISS.

High spatial resolution infrared camera as ISS external experiment

NASA Astrophysics Data System (ADS)

Eckehard, Lorenz; Frerker, Hap; Fitch, Robert Alan

High spatial resolution infrared camera as ISS external experiment for monitoring global climate changes uses ISS internal and external resources (eg. data storage). The optical experiment will consist of an infrared camera for monitoring global climate changes from the ISS. This technology was evaluated by the German small satellite mission BIRD and further developed in different ESA projects. Compared to BIRD the presended instrument uses proven sensor advanced technologies (ISS external) and ISS on board processing and storage capabili-ties (internal). The instrument will be equipped with a serial interfaces for TM/TC and several relay commands for the power supply. For data processing and storage a mass memory is re-quired. The access to actual attitude data is highly desired to produce geo referenced maps-if possible by an on board processing.

Expanded Benefits for Humanity from the International Space Station

NASA Technical Reports Server (NTRS)

Rai, Amelia; Robinson, Julie A.; Tate-Brown, Judy; Buckley, Nicole; Zell, Martin; Tasaki, Kazuyuki; Karabadzhak, Georgy; Sorokin, Igor V.; Pignataro, Salvatore

2016-01-01

In 2012, the International Space Station (ISS) partnership published the updated International Space Station Benefits for Humanity, 2nd edition, a compilation of stories about the many benefits being realized in the areas of human health, Earth observations and disaster response, and global education. This compilation has recently been revised to include updated statistics on the impacts of the benefits, and new benefits that have developed since the first publication. Two new sections have also been added to the book, economic development of space and innovative technology. This paper will summarize the updates on behalf of the ISS Program Science Forum, made up of senior science representatives across the international partnership. The new section on "Economic Development of Space" highlights case studies from public-private partnerships that are leading to a new economy in low earth orbit (LEO). Businesses provide both transportation to the ISS as well as some research facilities and services. These relationships promote a paradigm shift of government-funded, contractor-provided goods and services to commercially-provided goods purchased by government agencies. Other examples include commercial firms spending research and development dollars to conduct investigations on ISS and commercial service providers selling services directly to ISS users. This section provides examples of ISS as a test bed for new business relationships, and illustrates successful partnerships. The second new section, Innovative Technology, merges technology demonstration and physical science findings that promise to return Earth benefits through continued research. Robotic refueling concepts for life extensions of costly satellites in geo-synchronous orbit have applications to robotics in industry on Earth. Flame behavior experiments reveal insight into how fuel burns in microgravity leading to the possibility of improving engine efficiency on Earth. Nanostructures and smart fluids are examples of materials improvements that are being developed using data from ISS. The publication also expands the benefits of research results in human health, environmental change and disaster response and in education activities developed to capture student imaginations in support of science, technology, engineering and mathematics, or STEM, education internationally. Applications to human health of the knowledge gained on ISS continues to grow and improve healthcare technologies and our understanding of human physiology. Distinct benefits return to Earth from the only orbiting multi-disciplinary laboratory of its kind. The ISS is a stepping stone for future space exploration by providing findings that develop LEO and improve life on our planet.

ISS mapped from ICD-9-CM by a novel freeware versus traditional coding: a comparative study.

PubMed

Di Bartolomeo, Stefano; Tillati, Silvia; Valent, Francesca; Zanier, Loris; Barbone, Fabio

2010-03-31

Injury severity measures are based either on the Abbreviated Injury Scale (AIS) or the International Classification of diseases (ICD). The latter is more convenient because routinely collected by clinicians for administrative reasons. To exploit this advantage, a proprietary program that maps ICD-9-CM into AIS codes has been used for many years. Recently, a program called ICDPIC trauma and developed in the USA has become available free of charge for registered STATA users. We compared the ICDPIC calculated Injury Severity Score (ISS) with the one from direct, prospective AIS coding by expert trauma registrars (dAIS). The administrative records of the 289 major trauma cases admitted to the hospital of Udine-Italy from 1 July 2004 to 30 June 2005 and enrolled in the Italian Trauma Registry were retrieved and ICDPIC-ISS was calculated. The agreement between ICDPIC-ISS and dAIS-ISS was assessed by Cohen's Kappa and Bland-Altman charts. We then plotted the differences between the 2 scores against the ratio between the number of traumatic ICD-9-CM codes and the number of dAIS codes for each patient (DIARATIO). We also compared the absolute differences in ISS among 3 groups identified by DIARATIO. The discriminative power for survival of both scores was finally calculated by ROC curves. The scores matched in 33/272 patients (12.1%, k 0.07) and, when categorized, in 80/272 (22.4%, k 0.09). The Bland-Altman average difference was 6.36 (limits: minus 22.0 to plus 34.7). ICDPIC-ISS of 75 was particularly unreliable. The differences increased (p < 0.01) as DIARATIO increased indicating incomplete administrative coding as a cause of the differences. The area under the curve of ICDPIC-ISS was lower (0.63 vs. 0.76, p = 0.02). Despite its great potential convenience, ICPIC-ISS agreed poorly with its conventionally calculated counterpart. Its discriminative power for survival was also significantly lower. Incomplete ICD-9-CM coding was a main cause of these findings. Because this quality of coding is standard in Italy and probably in other European countries, its effects on the performances of other trauma scores based on ICD administrative data deserve further research. Mapping ICD-9-CM code 862.8 to AIS of 6 is an overestimation.

Development and Execution of Autonomous Procedures Onboard the International Space Station to Support the Next Phase of Human Space Exploration

NASA Technical Reports Server (NTRS)

Beisert, Susan; Rodriggs, Michael; Moreno, Francisco; Korth, David; Gibson, Stephen; Lee, Young H.; Eagles, Donald E.

2013-01-01

Now that major assembly of the International Space Station (ISS) is complete, NASA's focus has turned to using this high fidelity in-space research testbed to not only advance fundamental science research, but also demonstrate and mature technologies and develop operational concepts that will enable future human exploration missions beyond low Earth orbit. The ISS as a Testbed for Analog Research (ISTAR) project was established to reduce risks for manned missions to exploration destinations by utilizing ISS as a high fidelity micro-g laboratory to demonstrate technologies, operations concepts, and techniques associated with crew autonomous operations. One of these focus areas is the development and execution of ISS Testbed for Analog Research (ISTAR) autonomous flight crew procedures intended to increase crew autonomy that will be required for long duration human exploration missions. Due to increasing communications delays and reduced logistics resupply, autonomous procedures are expected to help reduce crew reliance on the ground flight control team, increase crew performance, and enable the crew to become more subject-matter experts on both the exploration space vehicle systems and the scientific investigation operations that will be conducted on a long duration human space exploration mission. These tests make use of previous or ongoing projects tested in ground analogs such as Research and Technology Studies (RATS) and NASA Extreme Environment Mission Operations (NEEMO). Since the latter half of 2012, selected non-critical ISS systems crew procedures have been used to develop techniques for building ISTAR autonomous procedures, and ISS flight crews have successfully executed them without flight controller involvement. Although the main focus has been preparing for exploration, the ISS has been a beneficiary of this synergistic effort and is considering modifying additional standard ISS procedures that may increase crew efficiency, reduce operational costs, and raise the amount of crew time available for scientific research. The next phase of autonomous procedure development is expected to include payload science and human research investigations. Additionally, ISS International Partners have expressed interest in participating in this effort. The recently approved one-year crew expedition starting in 2015, consisting of one Russian and one U.S. Operating Segment (USOS) crewmember, will be used not only for long duration human research investigations but also for the testing of exploration operations concepts, including crew autonomy.

Expanded benefits for humanity from the International Space Station

NASA Astrophysics Data System (ADS)

Rai, Amelia; Robinson, Julie A.; Tate-Brown, Judy; Buckley, Nicole; Zell, Martin; Tasaki, Kazuyuki; Karabadzhak, Georgy; Sorokin, Igor V.; Pignataro, Salvatore

2016-09-01

In 2012, the International Space Station (ISS) (Fig. 1) partnership published the updated International Space Station Benefits for Humanity[1], a compilation of stories about the many benefits being realized in the areas of human health, Earth observations and disaster response, and global education. This compilation has recently been revised to include updated statistics on the impacts of the benefits, and new benefits that have developed since the first publication. Two new sections have also been added to the book, economic development of space and innovative technology. This paper will summarize the updates on behalf of the ISS Program Science Forum, made up of senior science representatives across the international partnership. The new section on "Economic Development of Space" highlights case studies from public-private partnerships that are leading to a new economy in low earth orbit (LEO). Businesses provide both transportation to the ISS as well as some research facilities and services. These relationships promote a paradigm shift of government-funded, contractor-provided goods and services to commercially-provided goods purchased by government agencies. Other examples include commercial firms spending research and development dollars to conduct investigations on ISS and commercial service providers selling services directly to ISS users. This section provides examples of ISS as a test bed for new business relationships, and illustrates successful partnerships. The second new section, "Innovative Technology," merges technology demonstration and physical science findings that promise to return Earth benefits through continued research. Robotic refueling concepts for life extensions of costly satellites in geo-synchronous orbit have applications to robotics in industry on Earth. Flame behavior experiments reveal insight into how fuel burns in microgravity leading to the possibility of improving engine efficiency on Earth. Nanostructures and smart fluids are examples of materials improvements that are being developed using data from ISS. The publication also expands the benefits of research results in human health, environmental change and disaster response and in education activities developed to capture student imaginations in support of science, technology, engineering and mathematics, or STEM, education internationally. Applications to human health of the knowledge gained on ISS continue to grow and improve healthcare technologies and our understanding of human physiology. Distinct benefits return to Earth from the only orbiting multi-disciplinary laboratory of its kind. The ISS is a stepping stone for future space exploration by providing findings that develop LEO and improve life on our planet.

Environmental Effects on ISS Materials Aging (1998 to 2008)

NASA Technical Reports Server (NTRS)

Alred, John; Dasgupta, Rajib; Koontz, Steve; Soares, Carlos; Golden, John

2009-01-01

The performance of ISS spacecraft materials and systems on prolonged exposure to the low- Earth orbit (LEO) space flight are reported in this paper. In-flight data, flight crew observations, and the results of ground-based test and analysis directly supporting programmatic and operational decision-making are described. The space flight environments definitions (both natural and induced) used for ISS design, material selection, and verification testing are shown, in most cases, to be more severe than the actual flight environment accounting, in part, for the outstanding performance of ISS as a long mission duration spacecraft. No significant ISS material or system failures have been attributed to spacecraft-environments interactions. Nonetheless, ISS materials and systems performance data is contributing to our understanding of spacecraft material interactions with the spaceflight environment so as to reduce cost and risk for future spaceflight projects and programs. Orbital inclination (51.6 deg) and altitude (nominally near 360 km) determine the set of natural environment factors affecting the functional life of materials and systems on ISS. ISS operates in an electrically conducting environment (the F2 region of Earth s ionosphere) with well-defined fluxes of atomic oxygen, other charged and neutral ionospheric plasma species, solar UV, VUV, and x-ray radiation as well as galactic cosmic rays, trapped radiation, and solar cosmic rays. The LEO micrometeoroid and orbital debris environment is an especially important determinant of spacecraft design and operations. The magnitude of several environmental factors varies dramatically with latitude and longitude as ISS orbits the Earth. The high latitude orbital environment also exposes ISS to higher fluences of trapped energetic electrons, auroral electrons, solar cosmic rays, and galactic cosmic rays than would be the case in lower inclination orbits, largely as a result of the overall shape and magnitude of the geomagnetic field. As a result, ISS exposure to many environmental factors can vary dramatically along a particular orbital ground track, and from one ground track to the next, during any 24-hour period. The induced environment results from ISS interactions with the natural environment as well as environmental factors produced by ISS itself and visiting vehicles fleet. Examples include ram-wake effects, hypergolic thruster plume impingement, materials out-gassing, venting and dumping of fluids, and specific photovoltaic (PV) power system interactions with the ionospheric plasma (7-11). Vehicle size (L) and velocity (V), combined with the magnitude and direction of the geomagnetic field (B) produce operationally significant magnetic induction voltages (VxB.L) in ISS conducting structure during flight through high latitudes (> +45deg) during each orbit. Finally, an induced ionizing radiation environment is produced by cosmic ray interaction with the relatively thick ISS structure and shielding materials. The intent of this review article is, therefore, to provide a summary of selected aspects and elements of the ISS vehicle with regard to LEO space environment effects, associated with the much larger and more complicated vehicle that ISS has become since 1998, but also with an eye towards performance life extension to the year 2016 and beyond.

The ISS flight of Richard Garriott: a template for medicine and science investigation on future spaceflight participant missions.

PubMed

Jennings, Richard T; Garriott, Owen K; Bogomolov, Valery V; Pochuev, Vladimir I; Morgun, Valery V; Garriott, Richard A

2010-02-01

A total of eight commercial spaceflight participants have launched to the International Space Station (ISS) on Soyuz vehicles. Based on an older mean age compared to career astronauts and an increased prevalence of medical conditions, spaceflight participants have provided the opportunity to learn about the effect of space travel on crewmembers with medical problems. The 12-d Soyuz TMA-13/12 ISS flight of spaceflight participant Richard Garriott included medical factors that required preflight intervention, risk mitigation strategies, and provided the opportunity for medical study on-orbit. Equally important, Mr. Garriott conducted extensive medical, scientific, and educational payload operations during the flight. These included 7 medical experiments and a total of 15 scientific projects such as protein crystal growth, Earth observations/photography, educational projects with schools, and amateur radio. The medical studies included the effect of microgravity on immune function, sleep, bone loss, corneal refractive surgery, low back pain, motion perception, and intraocular pressure. The overall mission success resulted from non-bureaucratic agility in mission planning, cooperation with investigators from NASA, ISS, International Partners, and the Korean Aerospace Research Institute, in-flight support and leadership from a team with spaceflight and Capcom experience, and overall mission support from the ISS program. This article focuses on science opportunities that suborbital and orbital spaceflight participant flights offer and suggests that the science program on Richard Garriott's flight be considered a model for future orbital and suborbital missions. The medical challenges are presented in a companion article.

Impact of Solar Array Position on ISS Vehicle Charging

NASA Technical Reports Server (NTRS)

Alred, John; Mikatarian, Ronald; Koontz, Steve

2006-01-01

The International Space Station (ISS), because of its large structure and high voltage solar arrays, has a complex plasma interaction with the ionosphere in low Earth orbit (LEO). This interaction of the ISS US Segment photovoltaic (PV) power system with the LEO ionospheric plasma produces floating potentials on conducting elements of the ISS structure relative to the local plasma environment. To control the ISS floating potentials, two Plasma Contactor Units (PCUs) are installed on the Z1 truss. Each PCU discharges accumulated electrons from the Space Station structure, thus reducing the potential difference between the ISS structure and the surrounding charged plasma environment. Operations of the PCUs were intended to keep the ISS floating potential to 40 Volts (Reference 1). Exposed dielectric surfaces overlying conducting structure on the Space Station will collect an opposite charge from the ionosphere as the ISS charges. In theory, when an Extravehicular Activity (EVA) crewmember is tethered to structure via the crew safety tether or when metallic surfaces of the Extravehicular Mobility Unit (EMU) come in contact with conducting metallic surfaces of the ISS, the EMU conducting components, including the perspiration-soaked crewmember inside, can become charged to the Space Station floating potential. The concern is the potential dielectric breakdown of anodized aluminum surfaces on the EMU producing an arc from the EMU to the ambient plasma, or nearby ISS structure. If the EMU arcs, an electrical current of an unknown magnitude and duration may conduct through the EVA crewmember, producing an unacceptable condition. This electrical current may be sufficient to startle or fatally shock the EVA crewmember (Reference 2). Hence, as currently defined by the EVA community, the ISS floating potential for all nominal and contingency EVA worksites and translation paths must have a magnitude less than 40 volts relative to the local ionosphere at all times during EVA. Arcing from the EMU is classified as a catastrophic hazard, which requires two-failure tolerant controls, i.e., three hazard controls. Each PCU is capable of maintaining the ISS floating potential below the requirement during EVA. The two PCUs provide a single failure tolerant control of ISS floating potential. In the event of the failure of one or two PCUs, a combination of solar array shunting and turning the solar arrays into their own wakes will be used to supply control of the plasma hazard (Reference 3). The purpose of this paper is to present on-orbit information that shows that ISS solar array placement with respect to the ISS velocity vector can control solar array plasma charging, and hence, provide an operational control for the plasma hazard. Also, this paper will present on-orbit information that shows that shunting of the ISS solar arrays can control solar array plasma charging, and hence, provide an additional operational control for the plasma hazard.

SpeedyTime_7-Minus_Eighty_Degrees_Laboratory_Freezer_for_ ISS

NASA Image and Video Library

2017-08-23

SpeedyTime 7 – Minus Eighty Degrees Laboratory Freezer for ISS Cutting-edge science is on the daily menu on board the International Space Station, but where do the astronauts store their lab results before they’re shipped back to Earth? In one of a dozen large freezers, of course: in this SpeedyTime segment, Expedition 52 flight engineer Jack Fischer shines a light on the MELFI, Minus Eighty Degrees Laboratory Freezer for ISS. _______________________________________ FOLLOW THE SPACE STATION! Twitter: https://twitter.com/Space_Station Facebook: https://www.facebook.com/ISS Instagram: https://instagram.com/iss/

Extravehicular Mobility Unit (EMU) / International Space Station (ISS) Coolant Loop Failure and Recovery

NASA Technical Reports Server (NTRS)

Lewis, John F.; Cole, Harold; Cronin, Gary; Gazda, Daniel B.; Steele, John

2006-01-01

Following the Colombia accident, the Extravehicular Mobility Units (EMU) onboard ISS were unused for several months. Upon startup, the units experienced a failure in the coolant system. This failure resulted in the loss of Extravehicular Activity (EVA) capability from the US segment of ISS. With limited on-orbit evidence, a team of chemists, engineers, metallurgists, and microbiologists were able to identify the cause of the failure and develop recovery hardware and procedures. As a result of this work, the ISS crew regained the capability to perform EVAs from the US segment of the ISS.

The Floating Potential Probe (FPP) for ISS: Operations and Initial Results

NASA Technical Reports Server (NTRS)

Ferguson, Dale C.; Hillard, G. Barry; Morton, Thomas L.

2001-01-01

In this paper we report early results from the Floating Potential Probe (FPP) recently installed on the International Space Station (ISS). The data show that FPP properly measures the electrical potential of ISS structure with respect to the plasma it is flying through. FPP Langmuir probe data seem to give accurate measurements of the ambient plasma density, and are generally consistent with the IRI-90 model. FPP data are used to judge the performance of the ISS Plasma Contacting Units (PCUs), and to evaluate the extent of ISS charging in the absence of the PCUs.

Preliminary On-Orbit Neutron Dose Equivalent and Energy Spectrum Results from the ISS-RAD Fast Neutron Detector (FND)

NASA Technical Reports Server (NTRS)

Semones, Edward; Leitgab, Martin

2016-01-01

The ISS-RAD instrument was activated on ISS on February 1st, 2016. Integrated in ISS-RAD, the Fast Neutron Detector (FND) performs, for the first time on ISS, routine and precise direct neutron measurements between 0.5 and 8 MeV. Preliminary results for neutron dose equivalent and neutron flux energy distributions from online/on-board algorithms and offline ground analyses will be shown, along with comparisons to simulated data and previously measured neutron spectral data. On-orbit data quality and pre-launch analysis validation results will be discussed as well.

The ISS as a platform for a fully simulated mars voyage

NASA Astrophysics Data System (ADS)

Narici, Livio; Reitz, Guenther

2016-07-01

The ISS can mimic the impact of microgravity, radiation, living and psychological conditions that astronauts will face during a deep space cruise, for example to Mars. This suggests the ISS as the most valuable "analogue" for deep space exploration. NASA has indeed suggested a 'full-up deep space simulation on last available ISS Mission: 6/7 crew for one year duration; full simulation of time delays & autonomous operations'. This idea should be pushed further. It is indeed conceivable to use the ISS as the final "analogue", performing a real 'dry-run' of a deep space mission (such as a mission to Mars), as close as reasonably possible to what will be the real voyage. This Mars ISS dry run (ISS4Mars) would last 500-800 days, mimicking most of the challenges which will be undertaken such as length, isolation, food provision, decision making, time delays, health monitoring diagnostic and therapeutic actions and more: not a collection of "single experiments", but a complete exploration simulation were all the pieces will come together for the first in space simulated Mars voyage. Most of these challenges are the same that those that will be encountered during a Moon voyage, with the most evident exceptions being the duration and the communication delay. At the time of the Mars ISS dry run all the science and technological challenges will have to be mostly solved by dedicated works. These solutions will be synergistically deployed in the dry run which will simulate all the different aspects of the voyage, the trip to Mars, the permanence on the planet and the return to Earth. During the dry run i) There will be no arrivals/departure of spacecrafts; 2) Proper communications delay with ground will be simulated; 3) Decision processes will migrate from Ground to ISS; 4) Permanence on Mars will be simulated. Mars ISS dry run will use just a portion of the ISS which will be totally isolated from the rest of the ISS, leaving to the other ISS portions the task to provide the needed operational support for the ISS survival as well as the support for emergency situations. Beside helping in focusing the attention of the many space and space related programs to the quest for Mars, ISS4Mars will maintain a high level of attention of the funding institutions and provide an important focus for the general public. This talk will present the many scientific issues still open to be addressed (see for example the disciplinary reports of the THESEUS project#), some example of the challenging tests that could be performed, some of the operational challenges, as well as list some of the issues not likely/possible to be simulated. # http://www.theseus-eu.org

Coordination of International Risk-Reduction Investigations by the Multilateral Human Research Panel for Exploration

NASA Technical Reports Server (NTRS)

Charles, John B.; Bogomolov, Valery V.

2015-01-01

Effective use of the unique capabilities of the International Space Station (ISS) for risk reduction on future deep space missions involves preliminary work in analog environments to identify and evaluate the most promising techniques, interventions and treatments. This entails a consolidated multinational approach to biomedical research both on ISS and in ground analogs. The Multilateral Human Research Panel for Exploration (MHRPE) was chartered by the five ISS partners to recommend the best combination of partner investigations on ISS for risk reduction in the relatively short time available for ISS utilization. MHRPE will also make recommendations to funding agencies for appropriate preparatory analog work. In 2011, NASA's Human Research Program (HRP) and the Institute of Biomedical Problems (IBMP) of the Russian Academy of Science, acting for MHRPE, developed a joint US-Russian biomedical program for the 2015 one-year ISS mission (1YM) of American and Russian crewmembers. This was to evaluate the possibilities for multilateral research on ISS. An overlapping list of 16 HRP, 9 IBMP, 3 Japanese, 3 European and 1 Canadian investigations were selected to address risk-reduction goals in 7 categories: Functional Performance, Behavioral Health, Visual Impairment, Metabolism, Physical Capacity, Microbial and Human Factors. MHRPE intends to build on this bilateral foundation to recommend more fully-integrated multilateral investigations on future ISS missions commencing after the 1YM. MHRPE has also endorsed an on-going program of coordinated research on 6-month, one-year and 6-week missions ISS expeditions that is now under consideration by ISS managers. Preparatory work for these missions will require coordinated and collaborative campaigns especially in the psychological and psychosocial areas using analog isolation facilities in Houston, Köln and Moscow, and possibly elsewhere. The multilateral Human Analogs research working group (HANA) is the focal point of those planning discussions, with MHRPE coordinating between the national programs and then supporting implementation on ISS. Experience gained during preparations for the 1YM has identified improvements in both American and Russian processes to enable well-integrated investigations on all subsequent ISS expeditions. Among those is that the greatest efficiency is to be gained with investigations that are fully integrated from their conception, with co-principal investigators, a consolidated proposal and integrated plans for crewmember time and other flight-related resources. Analog investigations preceding future ISS expeditions will employ these lessons in efficiency to evaluate the techniques and tools to be validated aboard ISS. In this way, the resources and capabilities of ISS can be applied most efficiently to solving the problems facing astronauts of all nations in missions deep into the solar system.

Research on the International Space Station: Understanding Future Potential from Current Accomplishments

NASA Technical Reports Server (NTRS)

Robinson, Julie A.

2007-01-01

In November 2007, the International Space Station (ISS) will have supported seven years of continuous presence in space, with 15 Expeditions completed. These years have been characterized by the numerous technical challenges of assembly as well as operational and logistical challenges related to the availability of transportation by the Space Shuttle. During this period, an active set of early research objectives have also been accomplished alongside the assembly. This paper will review the research accomplishments on ISS to date, with the objective of drawing insights on the potential of future research following completion of ISS assembly. By the end of Expedition 15, an expected 121 U.S.-managed investigations will have been conducted on ISS, with 91 of these completed. Many of these investigations include multiple scientific objectives, with an estimated total of 334 scientists served. Through February 2007, 101 scientific publications have been identified. Another 184 investigations have been sponsored by ISS international partners, which independently track their scientists served and results publication. Through this survey of U.S. research completed on ISS, three different themes will be addressed: (1) How have constraints on transportation of mass to orbit affected the types of research successfully completed on the ISS to date? What lessons can be learned for increasing the success of ISS as a research platform during the period following the retirement of the Space Shuttle? (2) How have constraints on crew time for research during assembly and the active participation of crewmembers as scientists affected the types of research successfully completed on the ISS to date? What lessons can be learned for optimizing research return following the increase in capacity from 3 to 6 crewmembers (planned for 2009)? What lessons can be learned for optimizing research return after assembly is complete? (3) What do early research results indicate about the various scientific disciplines represented in investigations on ISS? Are there lessons specific to human research, technology development, life sciences, and physical sciences that can be used to increase future research accomplishments? Research has been conducted and completed on ISS under a set of challenging constraints during the past 7 years. The history of research accomplished on ISS during this time serves as an indicator of the value and potential of ISS when full utilization begins. By learning from our early experience in completing research on ISS, NASA and our partners can be positioned to optimize research returns as a full crew complement comes onboard, assembly is completed, and research begins in full.

Space Flight Resource Management for ISS Operations

NASA Technical Reports Server (NTRS)

Schmidt, Larry; Slack, Kelley; O'Keefe, William; Huning, Therese; Sipes, Walter; Holland, Albert

2011-01-01

This slide presentation reviews the International Space Station (ISS) Operations space flight resource management, which was adapted to the ISS from the shuttle processes. It covers crew training and behavior elements.

Exterior view of the ISS taken during EVA-3

NASA Image and Video Library

2011-05-25

ISS028-E-005416 (25 May 2011) --- The forward section of the space shuttle Endeavour is pictured with two components of the International Space Station (ISS) -- the Harmony node (left) and the European Space Agency's Columbus laboratory. Nine astronauts and cosmonauts continue to work inside the shirt-sleeve environment of the ISS and preparing for the final of four spacewalks on May 26.

ISS Has an Attitude! Determining ISS Attitude at the ISS Window Observational Research Facility (WORF) Using Landmarks

NASA Technical Reports Server (NTRS)

Runco, Susan K.; Pickard,Henry; Kowtha, Vijayanand; Jackson, Dan

2011-01-01

Universities and secondary schools can help solve a real issue for remote sensing from the ISS WORF through hands-on engineering and activities. Remote sensing technology is providing scientists with higher resolution, higher sensitivity sensors. Where is it pointing? - To take full advantage of these improved sensors, space platforms must provide commensurate improvements in attitude determination

IAF 15 Draft Paper

NASA Technical Reports Server (NTRS)

Menkin, Evgeny; Juillerat, Robert

2015-01-01

With the International Space Station Program transition from assembly to utilization, focus has been placed on the optimization of essential resources. This includes resources both resupplied from the ground and also resources produced by the ISS. In an effort to improve the use of two of these, the ISS Engineering teams, led by the ISS Program Systems Engineering and Integration Office, undertook an effort to modify the techniques use to perform several key on-orbit events. The primary purposes of this endeavor was to make the ISS more efficient in the use of the Russian-supplied fuel for the propulsive attitude control system and also to minimize the impacts to available ISS power due to the positioning of the ISS solar arrays. Because the ISS solar arrays are sensitive to several factors that are present when propulsive attitude control is used, they must be operated in a manner to protect them from damage. This results in periods of time where the arrays must be positioned, rather than autonomously tracking the sun, resulting in negative impacts to power generated by the solar arrays and consumed by both the ISS core systems and payload customers. A reduction in the number and extent of the events each year that require the ISS to use propulsive attitude control simultaneously accomplishes both these goals. Each instance where the ISS solar arrays normal sun tracking mode must be interrupted represent a need for some level of powerdown of equipment. As the magnitude of payload power requirements increases, and the efficiency of the ISS solar arrays decreases, these powerdowns caused by array positioning, will likely become more significant and could begin to negatively impact the payload operations. Through efforts such as this, the total number of events each year that require positioning of the arrays to unfavorable positions for power generation, in order to protect them against other constraints, are reduced. Optimization of propulsive events and transitioning some of them to non-propulsive CMG control significantly reduces propellant usage on the ISS leading to the reduction of the propellant delivery requirement. This results in move available upmass that can be used for delivering critical dry cargo, additional water, air, crew supplies and science experiments.

The features of radiation dose variations onboard ISS and Mir space station: comparative study.

PubMed

Tverskaya, L V; Panasyuk, M I; Reizman, S Ya; Sosnovets, E N; Teltsov, M V; Tsetlin, V V

2004-01-01

The dynamics of the ISS-measured radiation dose variations since August 2000 is studied. Use is made of the data obtained with the R-16 instrument, which consists of two ionization chambers behind different shielding thicknesses. The doses recorded during solar energetic particle (SEP) events are compared with the data obtained also by R-16 on Mir space station. The SEP events in the solar maximum of the current cycle make a much smaller contribution to the radiation dose compared with the October 1989 event recorded on Mir space station. In the latter event, the proton intensity was peaking during a strong magnetic storm. The storm-time effect of solar proton geomagnetic cutoff decreases on dose variations is estimated. The dose variations on Mir space stations due to formation of a new radiation belt of high-energy protons and electrons during a sudden commencement of March 24, 1991 storm are also studied. It was for the first time throughout the ISS and Mir dose measurement period that the counting rates recorded by both R-16 channels on ISS in 2001-2002 were nearly the same during some time intervals. This effect may arise from the decreases of relativistic electron fluxes in the outer radiation belt. c2004 COSPAR. Published by Elsevier Ltd. All rights reserved.

Docking Offset Between the Space Shuttle and the International Space Station and Resulting Impacts to the Transfer of Attitude Reference and Control

NASA Technical Reports Server (NTRS)

Helms, W. Jason; Pohlkamp, Kara M.

2011-01-01

The Space Shuttle does not dock at an exact 90 degrees to the International Space Station (ISS) x-body axis. This offset from 90 degrees, along with error sources within their respective attitude knowledge, causes the two vehicles to never completely agree on their attitude, even though they operate as a single, mated stack while docked. The docking offset can be measured in flight when both vehicles have good attitude reference and is a critical component in calculations to transfer attitude reference from one vehicle to another. This paper will describe how the docking offset and attitude reference errors between both vehicles are measured and how this information would be used to recover Shuttle attitude reference from ISS in the event of multiple failures. During STS-117, ISS on-board Guidance, Navigation and Control (GNC) computers began having problems and after several continuous restarts, the systems failed. The failure took the ability for ISS to maintain attitude knowledge. This paper will also demonstrate how with knowledge of the docking offset, the contingency procedure to recover Shuttle attitude reference from ISS was reversed in order to provide ISS an attitude reference from Shuttle. Finally, this paper will show how knowledge of the docking offset can be used to speed up attitude control handovers from Shuttle to ISS momentum management. By taking into account the docking offset, Shuttle can be commanded to hold a more precise attitude which better agrees with the ISS commanded attitude such that start up transients with the ISS momentum management controllers are reduced. By reducing start-up transients, attitude control can be transferred from Shuttle to ISS without the use of ISS thrusters saving precious on-board propellant, crew time and minimizing loads placed upon the mated stack.

Optimal Propellant Maneuver Flight Demonstrations on ISS

NASA Technical Reports Server (NTRS)

Bhatt, Sagar; Bedrossian, Nazareth; Longacre, Kenneth; Nguyen, Louis

2013-01-01

In this paper, first ever flight demonstrations of Optimal Propellant Maneuver (OPM), a method of propulsive rotational state transition for spacecraft controlled using thrusters, is presented for the International Space Station (ISS). On August 1, 2012, two ISS reorientations of about 180deg each were performed using OPMs. These maneuvers were in preparation for the same-day launch and rendezvous of a Progress vehicle, also a first for ISS visiting vehicles. The first maneuver used 9.7 kg of propellant, whereas the second used 10.2 kg. Identical maneuvers performed without using OPMs would have used approximately 151.1kg and 150.9kg respectively. The OPM method is to use a pre-planned attitude command trajectory to accomplish a rotational state transition. The trajectory is designed to take advantage of the complete nonlinear system dynamics. The trajectory choice directly influences the cost of the maneuver, in this case, propellant. For example, while an eigenaxis maneuver is kinematically the shortest path between two orientations, following that path requires overcoming the nonlinear system dynamics, thereby increasing the cost of the maneuver. The eigenaxis path is used for ISS maneuvers using thrusters. By considering a longer angular path, the path dependence of the system dynamics can be exploited to reduce the cost. The benefits of OPM for the ISS include not only reduced lifetime propellant use, but also reduced loads, erosion, and contamination from thrusters due to fewer firings. Another advantage of the OPM is that it does not require ISS flight software modifications since it is a set of commands tailored to the specific attitude control architecture. The OPM takes advantage of the existing ISS control system architecture for propulsive rotation called USTO control mode1. USTO was originally developed to provide ISS Orbiter stack attitude control capability for a contingency tile-repair scenario, where the Orbiter is maneuvered using its robotic manipulator relative to the ISS. Since 2005 USTO has been used for nominal ISS operations.

Characterizing ISS Charging Environments with On-Board Ionospheric Plasma Measurements

NASA Technical Reports Server (NTRS)

Minow, Jospeh I.; Craven, Paul D.; Coffey, Victoria N.; Schneider, Todd A.; Vaughn, Jason A.; Wright Jr, Kenneth; Parker, Paul D.; Mikatarian, Ronald R.; Kramer, Leonard; Hartman, William A.;

Specific abbreviated injury scale values are responsible for the underestimation of mortality in penetrating trauma patients by the injury severity score.

PubMed

Rowell, Susan E; Barbosa, Ronald R; Diggs, Brian S; Schreiber, Martin A; Holcomb, J B; Wade, C E; Brasel, K J; Vercruysse, G; MacLeod, J; Dutton, R P; Hess, J R; Duchesne, J C; McSwain, N E; Muskat, P; Johannigamn, J; Cryer, H M; Tillou, A; Cohen, M J; Pittet, J F; Knudson, P; De Moya, M A; Schreiber, M A; Tieu, B; Brundage, S; Napolitano, L M; Brunsvold, M; Sihler, K C; Beilman, G; Peitzman, A B; Zenait, M S; Sperry, J; Alarcon, L; Croce, M A; Minei, J P; Kozar, R; Gonzalez, E A; Stewart, R M; Cohn, S M; Mickalek, J E; Bulger, E M; Cotton, B A; Nunez, T C; Ivatury, R; Meredith, J W; Miller, P; Pomper, J; Marin, B

2011-08-01

The Injury Severity Score (ISS) is widely used as a method for rating severity of injury. The ISS is the sum of the squares of the three worst Abbreviated Injury Scale (AIS) values from three body regions. Patients with penetrating injuries tend to have higher mortality rates for a given ISS than patients with blunt injuries. This is thought to be secondary to the increased prevalence of multiple severe injuries in the same body region in patients with penetrating injuries, which the ISS does not account for. We hypothesized that the mechanism-based difference in mortality could be attributed to certain ISS ranges and specific AIS values by body region. Outcome and injury scoring data were obtained from transfused patients admitted to 23 Level I trauma centers. ISS values were grouped into categories, and a logistic regression model was created. Mortality for each ISS category was determined and compared with the ISS 1 to 15 group. An interaction term was added to evaluate the effect of mechanism. Additional logistic regression models were created to examine each AIS category individually. There were 2,292 patients in the cohort. An overall interaction between ISS and mechanism was observed (p = 0.049). Mortality rates between blunt and penetrating patients with an ISS between 25 and 40 were significantly different (23.6 vs. 36.1%; p = 0.022). Within this range, the magnitude of the difference in mortality was far higher for penetrating patients with head injuries (75% vs. 37% for blunt) than truncal injuries (26% vs. 17% for blunt). Penetrating trauma patients with an AIS head of 4 or 5, AIS abdomen of 3, or AIS extremity of 3 all had adjusted mortality rates higher than blunt trauma patients with those values. Significant differences in mortality between blunt and penetrating trauma patients exist at certain ISS and AIS category values. The mortality difference is greatest for head injured patients.

Integrating MBSE into Ongoing Projects: Requirements Validation and Test Planning for the ISS SAFER

NASA Technical Reports Server (NTRS)

Anderson, Herbert A.; Williams, Antony; Pierce, Gregory

2016-01-01

The International Space Station (ISS) Simplified Aid for Extra Vehicular Activity (EVA) Rescue (SAFER) is the spacewalking astronaut's final safety measure against separating from the ISS and being unable to return safely. Since the late 1990s, the SAFER has been a standard element of the spacewalking astronaut's equipment. The ISS SAFER project was chartered to develop a new block of SAFER units using a highly similar design to the legacy SAFER (known as the USA SAFER). An on-orbit test module was also included in the project to enable periodic maintenance/propulsion system checkout on the ISS SAFER. On the ISS SAFER project, model-based systems engineering (MBSE) was not the initial systems engineering (SE) approach, given the volume of heritage systems engineering and integration (SE&I) products. The initial emphasis was ensuring traceability to ISS program standards as well as to legacy USA SAFER requirements. The requirements management capabilities of the Cradle systems engineering tool were to be utilized to that end. During development, however, MBSE approaches were applied selectively to address specific challenges in requirements validation and test and verification (T&V) planning, which provided measurable efficiencies to the project. From an MBSE perspective, ISS SAFER development presented a challenge and an opportunity. Addressing the challenge first, the project was tasked to use the original USA SAFER operational and design requirements baseline, with a number of additional ISS program requirements to address evolving certification expectations for systems operating on the ISS. Additionally, a need to redesign the ISS SAFER avionics architecture resulted in a set of changes to the design requirements baseline. Finally, the project added an entirely new functionality for on-orbit maintenance. After initial requirements integration, the system requirements count was approaching 1000, which represented a growth of 4x over the original USA SAFER system. This presented the challenge - How to confirm that this new set of requirements set would result in the creation of the desired capability.

Material Testing in Support of the ISS Electrochemical Disinfection Feasibility Study

NASA Technical Reports Server (NTRS)

Rodriquez, Branelle; Shindo, David; Modica, Cathy

2012-01-01

Microbial contamination and subsequent growth in spacecraft water systems are constant concerns for missions involving human crews. The current potable water disinfectant for the International Space Station (ISS) is iodine; however, with the end of the Space Shuttle program, there is a need to develop redundant biocide systems that do not require regular up ]mass dependencies. Throughout the course of a year, four different electrochemical systems were investigated as a possible biocide for potable water on the ISS. Research has indicated that there is a wide variability with regards to efficacy in both concentration and exposure time of these disinfectants, therefore baseline efficacy values were established. This paper describes a series of tests performed in order to establish optimal concentrations and exposure times for four disinfectants against single and mixed species planktonic and biofilm bacteria. Results of the testing determined whether these electrochemical disinfection systems are able to produce a sufficient amount of chemical in both concentration and volume to act as a biocide for potable water on ISS.

Effect of simulated microgravity on growth and production of exopolymeric substances of Micrococcus luteus space and earth isolates.

PubMed

Mauclaire, Laurie; Egli, Marcel

2010-08-01

Microorganisms tend to form biofilms on surfaces, thereby causing deterioration of the underlaying material. In addition, biofilm is a potential health risk to humans. Therefore, microorganism growth is not only an issue on Earth but also in manned space habitats like the International Space Station (ISS). The aim of the study was to identify physiological processes relevant for Micrococcus luteus attachment under microgravity conditions. The results demonstrate that simulated microgravity influences physiological processes which trigger bacterial attachment and biofilm formation. The ISS strains produced larger amounts of exopolymeric substances (EPS) compared with a reference strain from Earth. In contrast, M. luteus strains were growing faster, and Earth as well as ISS isolates produced a higher yield of biomass under microgravity conditions than under normal gravity. Furthermore, microgravity caused a reduction of the colloidal EPS production of ISS isolates in comparison with normal gravity, which probably influences biofilm thickness and stability as well.

Severity of traumatic injuries predicting psychological outcomes: A surprising lack of empirical evidence.

PubMed

Boals, Adriel; Trost, Zina; Rainey, Evan; Foreman, Michael L; Warren, Ann Marie

2017-08-01

Despite widespread beliefs that trauma severity is related to levels of posttraumatic stress symptoms (PTSS), the empirical evidence to support such beliefs is lacking. In the current study we examined Injury Severity Score (ISS), a medical measure of event severity for physical injuries, in a sample of 460 patients admitted to a Level 1 Trauma Center. Results revealed no significant relationship between ISS and PTSS, depression, pain, and general physical and mental health at baseline, three months, and six months post-injury. However, at 12 months post-injury, ISS significantly predicted depression, pain, and physical health, but was unrelated to PTSS. The effect sizes of these relationships were small and would not remain significant if any adjustments for multiple comparisons were employed. We conclude that the relationship between ISS and PTSS is, at best, weak and inconsistent. The results are discussed in the broader picture of event severity and psychological outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

Insertion sequence diversity in archaea.

PubMed

Filée, J; Siguier, P; Chandler, M

2007-03-01

Insertion sequences (ISs) can constitute an important component of prokaryotic (bacterial and archaeal) genomes. Over 1,500 individual ISs are included at present in the ISfinder database (www-is.biotoul.fr), and these represent only a small portion of those in the available prokaryotic genome sequences and those that are being discovered in ongoing sequencing projects. In spite of this diversity, the transposition mechanisms of only a few of these ubiquitous mobile genetic elements are known, and these are all restricted to those present in bacteria. This review presents an overview of ISs within the archaeal kingdom. We first provide a general historical summary of the known properties and behaviors of archaeal ISs. We then consider how transposition might be regulated in some cases by small antisense RNAs and by termination codon readthrough. This is followed by an extensive analysis of the IS content in the sequenced archaeal genomes present in the public databases as of June 2006, which provides an overview of their distribution among the major archaeal classes and species. We show that the diversity of archaeal ISs is very great and comparable to that of bacteria. We compare archaeal ISs to known bacterial ISs and find that most are clearly members of families first described for bacteria. Several cases of lateral gene transfer between bacteria and archaea are clearly documented, notably for methanogenic archaea. However, several archaeal ISs do not have bacterial equivalents but can be grouped into Archaea-specific groups or families. In addition to ISs, we identify and list nonautonomous IS-derived elements, such as miniature inverted-repeat transposable elements. Finally, we present a possible scenario for the evolutionary history of ISs in the Archaea.

Methodology for Developing a Probabilistic Risk Assessment Model of Spacecraft Rendezvous and Dockings

NASA Technical Reports Server (NTRS)

Farnham, Steven J., II; Garza, Joel, Jr.; Castillo, Theresa M.; Lutomski, Michael

2011-01-01

In 2007 NASA was preparing to send two new visiting vehicles carrying logistics and propellant to the International Space Station (ISS). These new vehicles were the European Space Agency s (ESA) Automated Transfer Vehicle (ATV), the Jules Verne, and the Japanese Aerospace and Explorations Agency s (JAXA) H-II Transfer Vehicle (HTV). The ISS Program wanted to quantify the increased risk to the ISS from these visiting vehicles. At the time, only the Shuttle, the Soyuz, and the Progress vehicles rendezvoused and docked to the ISS. The increased risk to the ISS was from an increase in vehicle traffic, thereby, increasing the potential catastrophic collision during the rendezvous and the docking or berthing of the spacecraft to the ISS. A universal method of evaluating the risk of rendezvous and docking or berthing was created by the ISS s Risk Team to accommodate the increasing number of rendezvous and docking or berthing operations due to the increasing number of different spacecraft, as well as the future arrival of commercial spacecraft. Before the first docking attempt of ESA's ATV and JAXA's HTV to the ISS, a probabilistic risk model was developed to quantitatively calculate the risk of collision of each spacecraft with the ISS. The 5 rendezvous and docking risk models (Soyuz, Progress, Shuttle, ATV, and HTV) have been used to build and refine the modeling methodology for rendezvous and docking of spacecrafts. This risk modeling methodology will be NASA s basis for evaluating the addition of future ISS visiting spacecrafts hazards, including SpaceX s Dragon, Orbital Science s Cygnus, and NASA s own Orion spacecraft. This paper will describe the methodology used for developing a visiting vehicle risk model.

Orbiter Repair Maneuver Contingency Separation Methods and Analysis

NASA Technical Reports Server (NTRS)

Machula, Michael

2005-01-01

Repairing damaged thermal protection system tile requires the Space Shuttle to be oriented such that repair platform access from the International Space Station (ISS) is possible. To do this, the Space Shuttle uses the Orbiter Repair Maneuver (ORM), which utilizes the Shuttle Remote Manipulator System (SRMS) to rotate the Space Shuttle in relation to the ISS, for extended periods of time. These positions cause difficulties and challenges to performing a safe separation (no collision or thruster plume damage to sensitive ISS structures) should an inadvertent release occur or a contingency procedure require it. To help protect for an SRMS failure or other failures, a method for separating without collision and the ability to redock to ISS from the ORM configuration was needed. The contingency ORM separation solution elegantly takes advantage of orbital mechanics between ISS and the separating Space Shuttle. By pitching the ISS down approximately 45 degrees, in a majority of the ORM repair positions, the altitude difference between the ISS and Space Shuttle center of gravity is maximized. This altitude difference results in different orbital energies (orbital periods) causing objects to separate from each other without requiring translational firings. Using this method, a safe contingency ORM separation is made possible in many odd positions even though some separation positions point high powered thrusters directly at fragile ISS and Soyuz solar arrays. Documented in this paper are the development simulations and procedures of the contingency ORM separation and the challenges encountered with large constraints to work around. Lastly, a method of returning to redock with the ISS to pick up the stranded crew members (or transfer the final crew members) is explained as well as the thruster and ISS loads analysis.

Unique Capabilities of the Situational Awareness Sensor Suite for the ISS (SASSI) Mission Concept to Study the Equatorial Ionosphere

NASA Astrophysics Data System (ADS)

Habash Krause, L.; Gilchrist, B. E.; Minow, J. I.; Gallagher, D. L.; Hoegy, W. R.; Coffey, V. N.; Willis, E. M.

2014-12-01

We present an overview of a mission concept named Situational Awareness Sensor Suite for the ISS (SASSI) with a special focus here on low-latitude ionospheric plasma turbulence measurements relevant to equatorial spread-F. SASSI is a suite of sensors that improves Space Situational Awareness for the ISS local space environment, as well as unique ionospheric measurements and support active plasma experiments on the ISS. As such, the mission concept has both operational and basic research objectives. We will describe two compelling measurement techniques enabled by SASSI's unique mission architecture. That is, SASSI provides new abilities to 1) measure space plasma potentials in low Earth orbit over ~100 m relative to a common potential, and 2) to investigate multi-scale ionospheric plasma turbulence morphology simultaneously of both ~ 1 cm and ~ 10 m scale lengths. The first measurement technique will aid in the distinction of vertical drifts within equatorial plasma bubbles from the vertical motions of the bulk of the layer due to zonal electric fields. The second will aid in understanding ionospheric plasma turbulence cascading in scale sizes that affect over the horizon radar. During many years of ISS operation, we have conducted effective (but not perfect) human and robotic extravehicular activities within the space plasma environment surrounding the ISS structure. However, because of the complexity of the interaction between the ISS and the space environment, there remain important sources of unpredictable environmental situations that affect operations. Examples of affected systems include EVA safety, solar panel efficiency, and scientific instrument integrity. Models and heuristically-derived best practices are well-suited for routine operations, but when it comes to unusual or anomalous events or situations, there is no substitute for real-time monitoring. SASSI is being designed to deploy and operate a suite of low-cost, medium/high-TRL plasma sensors on the ISS Express Logistics Carrier for long-term observations and the Space Station Remote Manipulator System for short-term focused campaigns. The presentation will include a description of the instrument complement and an overview of the operations concept.

Determining the hospital trauma financial impact in a statewide trauma system.

PubMed

Mabry, Charles D; Kalkwarf, Kyle J; Betzold, Richard D; Spencer, Horace J; Robertson, Ronald D; Sutherland, Michael J; Maxson, Robert T

2015-04-01

There have been no comprehensive studies across an organized statewide trauma system using a standardized method to determine cost. Trauma financial impact includes the following costs: verification, response, and patient care cost (PCC). We conducted a survey of participating trauma centers (TCs) for federal fiscal year 2012, including separate accounting for verification and response costs. Patient care cost was merged with their trauma registry data. Seventy-five percent of the 2012 state trauma registry had data submitted. Each TC's reasonable cost from the Medicare Cost Report was adjusted to remove embedded costs for response and verification. Cost-to-charge ratios were used to give uniform PCC across the state. Median (mean ± SD) costs per patient for TC response and verification for Level I and II centers were $1,689 ($1,492 ± $647) and $450 ($636 ± $431) for Level III and IV centers. Patient care cost-median (mean ± SD) costs for patients with a length of stay >2 days rose with increasing Injury Severity Score (ISS): ISS <9: $6,787 ($8,827 ± $8,165), ISS 9 to 15: $10,390 ($14,340 ± $18,395); ISS 16 to 25: $15,698 ($23,615 ± $21,883); and ISS 25+: $29,792 ($41,407 ± $41,621), and with higher level of TC: Level I: $13,712 ($23,241 ± $29,164); Level II: $8,555 ($13,515 ± $15,296); and Levels III and IV: $8,115 ($10,719 ± $11,827). Patient care cost rose with increasing ISS, length of stay, ICU days, and ventilator days for patients with length of stay >2 days and ISS 9+. Level I centers had the highest mean ISS, length of stay, ICU days, and ventilator days, along with the highest PCC. Lesser trauma accounted for lower charges, payments, and PCC for Level II, III, and IV TCs, and the margin was variable. Verification and response costs per patient were highest for Level I and II TCs. Copyright © 2015 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

Abbreviated Injury Scale: not a reliable basis for summation of injury severity in trauma facilities?

PubMed

Ringdal, Kjetil G; Skaga, Nils Oddvar; Hestnes, Morten; Steen, Petter Andreas; Røislien, Jo; Rehn, Marius; Røise, Olav; Krüger, Andreas J; Lossius, Hans Morten

2013-05-01

Injury severity is most frequently classified using the Abbreviated Injury Scale (AIS) as a basis for the Injury Severity Score (ISS) and the New Injury Severity Score (NISS), which are used for assessment of overall injury severity in the multiply injured patient and in outcome prediction. European trauma registries recommended the AIS 2008 edition, but the levels of inter-rater agreement and reliability of ISS and NISS, associated with its use, have not been reported. Nineteen Norwegian AIS-certified trauma registry coders were invited to score 50 real, anonymised patient medical records using AIS 2008. Rater agreements for ISS and NISS were analysed using Bland-Altman plots with 95% limits of agreement (LoA). A clinically acceptable LoA range was set at ± 9 units. Reliability was analysed using a two-way mixed model intraclass correlation coefficient (ICC) statistics with corresponding 95% confidence intervals (CI) and hierarchical agglomerative clustering. Ten coders submitted their coding results. Of their AIS codes, 2189 (61.5%) agreed with a reference standard, 1187 (31.1%) real injuries were missed, and 392 non-existing injuries were recorded. All LoAs were wider than the predefined, clinically acceptable limit of ± 9, for both ISS and NISS. The joint ICC (range) between each rater and the reference standard was 0.51 (0.29,0.86) for ISS and 0.51 (0.27,0.78) for NISS. The joint ICC (range) for inter-rater reliability was 0.49 (0.19,0.85) for ISS and 0.49 (0.16,0.82) for NISS. Univariate linear regression analyses indicated a significant relationship between the number of correctly AIS-coded injuries and total number of cases coded during the rater's career, but no significant relationship between the rater-against-reference ISS and NISS ICC values and total number of cases coded during the rater's career. Based on AIS 2008, ISS and NISS were not reliable for summarising anatomic injury severity in this study. This result indicates a limitation in their use as benchmarking tools for trauma system performance. Copyright © 2012 Elsevier Ltd. All rights reserved.

iss056e009782

NASA Image and Video Library

2018-06-11

iss056e009782 (June 11, 2018) --- Expedition 56 Flight Engineer Alexander Gerst of the European Space Agency (ESA) is seated in the Columbus laboratory module participating in the Grip study. Grip is an ESA-sponsored experiment that is researching how the nervous system adapts to microgravity. Observations may improve the design of safer space habitats and help patients on Earth with neurological diseases.

Education Payload Operation - Kit D

NASA Technical Reports Server (NTRS)

Keil, Matthew

2009-01-01

Education Payload Operation - Kit D (EPO-Kit D) includes education items that will be used to support the live International Space Station (ISS) education downlinks and Education Payload Operation (EPO) demonstrations onboard the ISS. The main objective of EPO-Kit D supports the National Aeronautics and Space Administration (NASA) goal of attracting students to study and seek careers in science, technology, engineering, and mathematics.

Complete Closed Genome Sequence of Nontoxigenic Invasive Corynebacterium diphtheriae bv. mitis Strain ISS 3319.

PubMed

Azevedo Antunes, Camila; Richardson, Emily J; Quick, Joshua; Fuentes-Utrilla, Pablo; Isom, Georgia L; Goodall, Emily C; Möller, Jens; Hoskisson, Paul A; Mattos-Guaraldi, Ana Luiza; Cunningham, Adam F; Loman, Nicholas J; Sangal, Vartul; Burkovski, Andreas; Henderson, Ian R

2018-02-01

The genome sequence of the human pathogen Corynebacterium diphtheriae bv. mitis strain ISS 3319 was determined and closed in this study. The genome is estimated to have 2,404,936 bp encoding 2,257 proteins. This strain also possesses a plasmid of 1,960 bp. Copyright © 2018 Azevedo Antunes et al.

Information Security Analysis: A Study to Analyze the Extent to Which Information Security Systems Can Be Utilized to Prevent Intoxicated Individuals from Driving

ERIC Educational Resources Information Center

Pierre, Joseph D.

2011-01-01

Information security systems (ISS) have been designed to protect assets from damages and from unauthorized access internally as well as externally. This research is promising similar protection from ISS methods that could prevent intoxicated individuals under the influence of alcohol from driving. However, previous research has shown significant…

[Risk profiling in cancer surveillance in contaminated sites: an example from the ISS-AIRTUM collaborative study].

PubMed

Catelan, Dolores; Buzzoni, Carlotta; Coviello, Enzo; Crocetti, Emanuele; Pasetto, Roberto; Pirastu, Roberta; Biggeri, Annibale

2014-01-01

Epidemiological surveillance on high risk environmental areas or areas covered by cancer registration yields long inventories of relative risks. Summaries of the results' tables must be produced to identify priorities and tailor public health actions. The aim is, therefore, to draw conclusions from each area's disease profile, or from the area signature of each disease.With this inmind, we used data on cancer incidence from 17 Cancer Registries that participated in the ISS-AIRTUM (National Institute of Health-Italian Network of Cancer Registries) study, and we produced conditional and marginal rankings of areas/diseases using a multivariate hierarchical Bayesian model. In this context, it is important to obtain an uncertainty evaluation by calculating the credibility intervals of ranks. The areas marginal ranking shows a large overlapping of credibility intervals, such that it is not possible to speak of a limited number of ISS-AIRTUM areas as being particularly affected. Every ISS-AIRTUMarea, therefore,must be considered individually and ordering themby ranking of cancer incidence wouldn't be appropriate. Instead,marginal ranking of diseases highlights the impact of asbestos exposure in all the analyzed areas.

Charter for Systems Engineer Working Group

NASA Technical Reports Server (NTRS)

Suffredini, Michael T.; Grissom, Larry

2015-01-01

This charter establishes the International Space Station Program (ISSP) Mobile Servicing System (MSS) Systems Engineering Working Group (SEWG). The MSS SEWG is established to provide a mechanism for Systems Engineering for the end-to-end MSS function. The MSS end-to-end function includes the Space Station Remote Manipulator System (SSRMS), the Mobile Remote Servicer (MRS) Base System (MBS), Robotic Work Station (RWS), Special Purpose Dexterous Manipulator (SPDM), Video Signal Converters (VSC), and Operations Control Software (OCS), the Mobile Transporter (MT), and by interfaces between and among these elements, and United States On-Orbit Segment (USOS) distributed systems, and other International Space Station Elements and Payloads, (including the Power Data Grapple Fixtures (PDGFs), MSS Capture Attach System (MCAS) and the Mobile Transporter Capture Latch (MTCL)). This end-to-end function will be supported by the ISS and MSS ground segment facilities. This charter defines the scope and limits of the program authority and document control that is delegated to the SEWG and it also identifies the panel core membership and specific operating policies.

Outcome of In Situ Septoplasty and Extracorporeal Subtotal Septal Reconstruction in Crooked Noses: A Randomized Self-Controlled Study.

PubMed

Gode, Sercan; Benzer, Murat; Uslu, Mustafa; Kaya, Isa; Midilli, Rasit; Karci, Bulent

2018-02-01

Severe dorsal deviations in crooked noses are treated by either in situ septoplasty with asymmetric spreader grafts (ISS) or extracorporeal subtotal septal reconstruction (ECS). To our knowledge, except one retrospective study, there is no other that compares the objective and subjective results of these two treatment modalities. The aim of this study was to compare the aesthetic and functional outcomes of ECS and ISS in crooked noses. This study was carried out on 40 patients (ISS in 20 patients and ECS in 20 patients) who underwent external rhinoplasty surgery due to crooked noses between May 2014 and January 2016. While performing rhinoplasty on the patients, the decision of whether to use the ECS or ISS technique was randomized in a sequential fashion. Surgical outcomes were assessed and compared using the anthropometric measurement of photographs with Rhinobase software. Subjective assessments of nasal obstruction and aesthetic satisfaction were evaluated with a visual analog scale. There was a significant difference between rhinion deviation angle, supratip deviation angle (SDA) and tip deviation angle pre- and postoperatively in the ECS group, whereas in the ISS group, except SDA, all other postoperative angles were significantly improved from preoperative values (p = 0.218). The nasal tip projection in the ECS and ISS groups was 29.48, 31.5 preoperatively and 29.78, 31.26 postoperatively. The mean postoperative nasal tip projection value (p > 0.005) did not change significantly compared to the preoperative value in both groups. The mean postoperative value of nasolabial (p = 0.226) angle did not change significantly compared to the mean preoperative one in the ECS group. However, in the ISS group, the mean postoperative value of nasolabial (p = 0.001) angle significantly improved compared to the mean preoperative value. There was significant improvement in both groups, while improvements in both functional and aesthetic outcomes were much higher in the extracorporeal group. None of the patients had postoperative nasal obstruction that required revision surgery. One patient underwent revision rhinoplasty due to an irregularity on the nasal dorsum in the ECS group. This is the first study that compares subjective and objective aesthetic and functional outcomes of crooked nose surgery according to two common septoplasty techniques in a randomized self-controlled fashion. This study was effective in both objectively and subjectively comparing the functional and aesthetic aspect of the patients submitted to two common different techniques of treatment of nasal deviations in crooked nose patients. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Expedition Seven Science Officer Lu with laptop

NASA Image and Video Library

2003-07-16

ISS007-E-10478 (16 July 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, uses a computer in the Destiny laboratory on the International Space Station (ISS).

International Space Station (ISS)

NASA Image and Video Library

1994-09-21

Artist's concept of the final configuration of the International Space Station (ISS) Alpha. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide an unprecedented undertaking in scientific, technological, and international experimentation.

International Space Station (ISS)

NASA Image and Video Library

1994-04-20

An artist's concept of a fully deployed International Space Station (ISS) Alpha. The ISS-A is a multidisciplinary laboratory, technology test bed, and observatory that will provide an unprecedented undertaking in scientific, technological, and international experiments.

Development and Certification of Ultrasonic Background Noise Test (UBNT) System for use on the International Space Station (ISS)

NASA Technical Reports Server (NTRS)

Prosser, William H.; Madaras, Eric I.

2011-01-01

As a next step in the development and implementation of an on-board leak detection and localization system on the International Space Station (ISS), there is a documented need to obtain measurements of the ultrasonic background noise levels that exist within the ISS. This need is documented in the ISS Integrated Risk Management System (IRMA), Watch Item #4669. To address this, scientists and engineers from the Langley Research Center (LaRC) and the Johnson Space Center (JSC), proposed to the NASA Engineering and Safety Center (NESC) and the ISS Vehicle Office a joint assessment to develop a flight package as a Station Development Test Objective (SDTO) that would perform ultrasonic background noise measurements within the United States (US) controlled ISS structure. This document contains the results of the assessment

International Space Station Research Benefits for Humanity

NASA Technical Reports Server (NTRS)

Thumm, Tracy; Robinson, Julie A.; Johnson-Green, Perry; Buckley, Nicole; Karabadzhak, George; Nakamura, Tai; Kamigaichi, Shigeki; Sorokin, Igor V.; Zell, Martin; Fuglesang, Christer;

International Space Station Benefits for Humanity

NASA Technical Reports Server (NTRS)

Thumm, Tracy L.; Robinson, Julie A.; Buckley, Nicole; Johnson-Green, Perry; Kamigaichi, Shigeki; Karabadzhak, George; Nakamura, Tai; Sabbagh, Jean; Sorokin, Igor; Zell, Martin

2012-01-01

The ISS partnership has seen a substantial increase in research accomplished, crew efforts devoted to research, and results of ongoing research and technology development. The ISS laboratory is providing a unique environment for research and international collaboration that benefits humankind. Benefits come from the engineering development, the international partnership, and from the research results. Benefits can be of three different types: scientific discovery, applications to life on Earth, and applications to future exploration. Working across all ISS partners, we identified key themes where the activities on the ISS improve the lives of people on Earth--not only within the partner nations, but also in other nations of the world. Three major themes of benefits to life on earth emerged from our review: benefits to human health, education, and Earth observation and disaster response. Other themes are growing as use of the ISS continues. Benefits to human health range from advancements in surgical technology, improved telemedicine, and new treatments for disease. Earth observations from the ISS provide a wide range of observations that include: marine vessel tracking, disaster monitoring and climate change. The ISS participates in a number of educational activities aimed to inspire students of all ages to learn about science, technology, engineering and mathematics. To date over 63 countries have directly participated in some aspect of ISS research or education. In summarizing these benefits and accomplishments, ISS partners are also identifying ways to further extend the benefits to people in developing countries for the benefits of humankind.

A Year in the Life of International Space Station

NASA Technical Reports Server (NTRS)

Uri, John J.

2006-01-01

The past twelve months (October 2005 to September 2006) have been among the busiest in the life of the International Space Station (ISS), both in terms of on-orbit operations as well as future planning, for both ISS systems and research. The Expedition 12 and 13 crews completed their missions successfully, carrying out research for Russia, the United States, Europe and Japan, and bringing continuous ISS occupancy to nearly six years. The European Space Agency's (ESA) first Long Duration Mission on ISS is underway, involving significant international research. The Expedition 14 crew completed its training and is embarking on its own 6-month mission with a full slate of international research. Future crews are in training for their respective assembly and research missions. Shuttle flights resumed after a 10-month hiatus, delivering new research facilities and resuming assembly of ISS. ESA's Columbus research module was delivered to the Kennedy Space Center, joining Japan's Kibo research module already there. Following preflight testing, the two modules will launch in 2007 and 2008, respectively, joining Destiny as ISS's research infrastructure. A revised ISS configuration and assembly sequence were endorsed by all the Partners, with a reduced number of Shuttle flights, but for the first time including plans for post-Shuttle ISS operations after 2010. The new plan will pose significant challenges to the ISS research community. As Europe and Japan build their on-orbit research infrastructure, and long-term plans become firmer, the next 12 months should prove to be equally challenging and exciting.

Validation of a self-reported HIV symptoms list: the ISS-HIV symptoms scale.

PubMed

Bucciardini, Raffaella; Pugliese, Katherina; Francisci, Daniela; Costantini, Andrea; Schiaroli, Elisabetta; Cognigni, Miriam; Tontini, Chiara; Lucattini, Stefano; Fucili, Luca; Di Gregorio, Massimiliano; Mirra, Marco; Fragola, Vincenzo; Pompili, Sara; Murri, Rita; Vella, Stefano

2016-01-01

To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went through the following steps: (1) review of HIV/AIDS literature; (2) focus group; (3) pre-test analysis; (4) scale validation. The 22 symptoms of HIV-ISS symptoms scale were clustered in five factors: pain/general discomfort (7 items); depression/anxiety (4 items); emotional reaction/psychological distress (5 items); gastrointestinal discomfort (4 items); sexual discomfort (2 items). The internal consistence reliability was for all factors within the minimum accepted standard of 0.70. The results of this study provide a preliminary evidence of the reliability and validity of the ISS-HIV symptoms scale. In the new era where HIV infection has been transformed into a chronic diseases and patients are experiencing a complex range of symptoms, the ISS-HIV symptoms scale may represent an useful tool for a comprehensive symptom assessment with the advantage of being easy to fill out by patients and potentially attractive to physicians mainly because it is easy to understand and requires short time to interpret the results.

Microstructure and Macrosegregation Study of Directionally Solidified Al-7Si Samples Processed Terrestrially and Aboard the International Space Station

NASA Technical Reports Server (NTRS)

Angart, Samuel; Erdman, R. G.; Poirier, David R.; Tewari, S.N.; Grugel, R. N.

2014-01-01

This talk reports research that has been carried out under the aegis of NASA as part of a collaboration between ESA and NASA for solidification experiments on the International Space Station (ISS). The focus has been on the effect of convection on the microstructural evolution and macrosegregation in hypoeutectic Al-Si alloys during directional solidification (DS). The DS-experiments have been carried out under 1-g at Cleveland State University (CSU) and under low-g on the International Space Station (ISS). The thermal processing-history of the experiments is well defined for both the terrestrially-processed samples and the ISS-processed samples. We have observed that the primary dendrite arm spacings of two samples grown in the low-g environment of the ISS show good agreement with a dendrite-growth model based on diffusion controlled growth. The gravity-driven convection (i.e., thermosolutal convection) in terrestrially grown samples has the effect of decreasing the primary dendrite arm spacings and causes macrosgregation. In order to process DS-samples aboard the ISS, dendritic-seed crystals have to partially remelted in a stationary thermal gradient before the DS is carried out. Microstructural changes and macrosegregation effects during this period are described.

Furnishing spaceship environment: evaluation of bacterial biofilms on different materials used inside International Space Station.

PubMed

Perrin, Elena; Bacci, Giovanni; Garrelly, Laurent; Canganella, Francesco; Bianconi, Giovanna; Fani, Renato; Mengoni, Alessio

2018-05-08

Performed inside International Space Station (ISS) from 2011 to 2016, VIABLE (eValuatIon And monitoring of microBiofiLms insidE International Space Station) ISS was a long-lasting experiment aimed at evaluating the bacterial contamination on different surface space materials subjected to different pre-treatment, to provide useful information for future space missions. In this work, surfaces samples of the VIABLE ISS experiment were analyzed to determine both the total bacterial load (ATP-metry, qPCR) and the composition of the microbial communities (16S rRNA genes amplicon sequencing). Data obtained showed a low bacterial contamination of all the surfaces, with values in agreement with those allowed inside ISS, and with a taxonomic composition similar to those found in previous studies (Enterobacteriales, Bacillales, Lactobacillales and Actinomycetales). No pre-treatment or material effect were observed on both the bacterial load and the composition of the communities, but for both a slight effect of the position (expose/not expose to air) was observed. In conclusion, under the conditions used for VIABLE ISS, no material or pre-treatment seems to be better than others in terms of quantity and type of bacterial contamination. Copyright © 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

CHeCS (Crew Health Care Systems): International Space Station (ISS) Medical Hardware Catalog. Version 10.0

NASA Technical Reports Server (NTRS)

2011-01-01

The purpose of this catalog is to provide a detailed description of each piece of hardware in the Crew Health Care System (CHeCS), including subpacks associated with the hardware, and to briefly describe the interfaces between the hardware and the ISS. The primary user of this document is the Space Medicine/Medical Operations ISS Biomedical Flight Controllers (ISS BMEs).

The Inviting School Survey--Revised (ISS--R): A Survey for Measuring the Invitational Qualities (I.Q.) of the Total School Climate

ERIC Educational Resources Information Center

Smith, Kenneth H.

2005-01-01

This article describes the revised Inviting School Survey (ISS-R) which is a 50- item checklist based on the 100-item Inviting School Survey (Purkey & Schmidt, 1990, Purkey & Fuller, 1995). Both the original ISS and the ISS-R are designed for use by Grade Four students and above, teachers, school administrators and others associated with the…

ISS 7A.1 Flight Control Team Photo in BFCR

NASA Image and Video Library

2001-08-16

JSC2001-02229 (16 August 2001) --- The members of the STS-105/ISS 7A.1 Orbit 1 team pose for a group portrait in the International Space Station (ISS) flight control room (BFCR) in Houston’s Mission Control Center (MCC). Flight director Mark Ferring is kneeling as he holds the Expedition Three mission logo. Astronaut Stephanie D. Wilson, ISS spacecraft communicator (CAPCOM), is standing behind Ferring.

The Applicability of the International Staging System in Chinese Patients with Multiple Myeloma Receiving Bortezomib or Thalidomide-Based Regimens as Induction Therapy: A Multicenter Analysis

PubMed Central

Lu, Jing; Lu, Jin; Liu, Aijun; Fu, Weijun; Du, Juan; Huang, Xiaojun; Chen, Wenming; Hou, Jian

2015-01-01

The International Staging System (ISS) is the most important prognostic system for multiple myeloma (MM). It was identified in the era of conventional agents. The outcome of MM has significantly changed by novel agents. Thus the applicability of ISS system in the era of novel agents in Chinese patients needs to be demonstrated. We retrospectively analyzed the clinical outcomes and prognostic significance of ISS system in 1016 patients with newly diagnosed multiple myeloma in Chinese patients between 2008 and 2012, who received bortezomib- or thalidomide-based regimens as first-line therapy. The median overall survival (OS) of patients for ISS stages I/II/III was not reached/55.4 months/41.7 months (p < 0.001), and the median progression-free survival (PFS) was 30/29.5/25 months (p = 0.072), respectively. Statistically significant difference in survival was confirmed among three ISS stages in thalidomide-based group, but not between ISS stages I and II in bortezomib-based group. These findings suggest that ISS system can predict the survival in the era of novel agents in Chinese MM patients, and bortezomib may have the potential to partially overcome adverse effect of risk factors on survival, especially in higher stage of ISS system. PMID:26640799

Ambient mass density effects on the International Space Station (ISS) microgravity experiments

NASA Technical Reports Server (NTRS)

Smith, O. E.; Adelfang, S. I.; Smith, R. E.

1996-01-01

The Marshall engineering thermosphere model was specified by NASA to be used in the design, development and testing phases of the International Space Station (ISS). The mass density is the atmospheric parameter which most affects the ISS. Under simplifying assumptions, the critical ambient neutral density required to produce one micro-g on the ISS is estimated using an atmospheric drag acceleration equation. Examples are presented for the critical density versus altitude, and for the critical density that is exceeded at least once a month and once per orbit during periods of low and high solar activity. An analysis of the ISS orbital decay is presented.

Crew Transportation Technical Management Processes

NASA Technical Reports Server (NTRS)

Mckinnie, John M. (Compiler); Lueders, Kathryn L. (Compiler)

2013-01-01

Under the guidance of processes provided by Crew Transportation Plan (CCT-PLN-1100), this document, with its sister documents, International Space Station (ISS) Crew Transportation and Services Requirements Document (CCT-REQ-1130), Crew Transportation Technical Standards and Design Evaluation Criteria (CCT-STD-1140), Crew Transportation Operations Standards (CCT STD-1150), and ISS to Commercial Orbital Transportation Services Interface Requirements Document (SSP 50808), provides the basis for a National Aeronautics and Space Administration (NASA) certification for services to the ISS for the Commercial Provider. When NASA Crew Transportation System (CTS) certification is achieved for ISS transportation, the Commercial Provider will be eligible to provide services to and from the ISS during the services phase.

International Space Station (ISS)

NASA Image and Video Library

1998-01-01

This artist's concept depicts the completely assembled International Space Station (ISS) passing over Florida and the Bahamas. As a gateway to permanent human presence in space, the Space Station Program is to expand knowledge benefiting all people and nations. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation. Experiments to be conducted in the ISS include: microgravity research, Earth science, space science, life sciences, space product development, and engineering research and technology. The sixteen countries participating in the ISS are: United States, Russian Federation, Canada, Japan, United Kingdom, Germany, Italy, France, Norway, Netherlands, Belgium, Spain, Denmark, Sweden, Switzerland, and Brazil.

International Space Station (ISS)

NASA Image and Video Library

1998-01-01

This artist's digital concept depicts the completely assembled International Space Station (ISS) passing over Florida. As a gateway to permanent human presence in space, the Space Station Program is to expand knowledge benefiting all people and nations. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation. Experiments to be conducted in the ISS include: microgravity research, Earth science, space science, life sciences, space product development, and engineering research and technology. The sixteen countries participating the ISS are: United States, Russian Federation, Canada, Japan, United Kingdom, Germany, Italy, France, Norway, Netherlands, Belgium, Spain, Denmark, Sweden, Switzerland, and Brazil.

ISS NASA Social

NASA Image and Video Library

2013-02-20

Tara Ruttley, International Space Station Program Scientist, talks about the benefits of conducting science experiments on ISS at a NASA Social exploring science on the ISS at NASA Headquarters, Wednesday, Feb. 20, 2013 in Washington. Photo Credit: (NASA/Carla Cioffi)

Sexual arousal and desire: interrelations and responses to three modalities of sexual stimuli.

PubMed

Goldey, Katherine L; van Anders, Sari M

2012-09-01

Traditionally, sexual desire is understood to occur spontaneously, but more recent models propose that desire responds to sexual stimuli. To experimentally assess whether sexual stimuli increased sexual desire; to compare how sexual arousal and desire responded to three modalities of sexual stimuli: erotic story, unstructured fantasy, and the Imagined Social Situation Exercise (ISSE). In an online study, participants (128 women, 98 men) were randomly assigned to one of four arousal conditions (ISSE, story, fantasy, or neutral), and then completed desire measures. In the ISSE, participants imagined and wrote about a positive sexual encounter with a self-defined attractive person. Sexual arousal (perceived genital, psychological, and perceived autonomic), anxiety, positive and negative affect, and state sexual desire via self-report measures pre- and post-condition; "trait" desire via the Sexual Desire Inventory post-condition. All three sexual conditions significantly increased sexual arousal and positive affect compared with the neutral condition, with trends for higher arousal to unstructured fantasy than the ISSE or story conditions. Sexual conditions significantly increased scores on state measures of sexual desire. In addition, sexual context influenced measurement of "trait" solitary sexual desire in women, such that women reported significantly higher trait desire after the neutral and ISSE conditions vs. fantasy. Results highlight the responsiveness of sexual desire, problems with measurement of desire as a long-term trait, trade-offs of using the ISSE and other stimuli in sexuality research, and the need to address context in discussions of women's and men's desire. © 2012 International Society for Sexual Medicine.

STS-114 Flight Day 3 Highlights

NASA Technical Reports Server (NTRS)

2005-01-01

Video coverage of Day 3 includes highlights of STS-114 during the approach and docking of Discovery with the International Space Station (ISS). The Return to Flight continues with space shuttle crew members (Commander Eileen Collins, Pilot James Kelly, Mission Specialists Soichi Noguchi, Stephen Robinson, Andrew Thomas, Wendy Lawrence, and Charles Camarda) seen in onboard activities on the fore and aft portions of the flight deck during the orbiter's approach. Camarda sends a greeting to his family, and Collins maneuvers Discovery as the ISS appears steadily closer in sequential still video from the centerline camera of the Orbiter Docking System. The approach includes video of Discovery from the ISS during the orbiter's Rendezvous Pitch Maneuver, giving the ISS a clear view of the thermal protection systems underneath the orbiter. Discovery docks with the Destiny Laboratory of the ISS, and the shuttle crew greets the Expedition 11 crew (Commander Sergei Krikalev and NASA ISS Science Officer and Flight Engineer John Phillips) of the ISS onboard the station. Finally, the Space Station Remote Manipulator System hands the Orbiter Boom Sensor System to its counterpart, the Shuttle Remote Manipulator System.

ISS General Resource Reel

NASA Technical Reports Server (NTRS)

1998-01-01

This video is a collection of computer animations and live footage showing the construction and assembly of the International Space Station (ISS). Computer animations show the following: (1) ISS fly around; (2) ISS over a sunrise seen from space; (3) the launch of the Zarya Control Module; (4) a Proton rocket launch; (5) the Space Shuttle docking with Zarya and attaching Zarya to the Unity Node; (6) the docking of the Service Module, Zarya, and Unity to Soyuz; (7) the Space Shuttle docking to ISS and installing the Z1 Truss segment and the Pressurized Mating Adapter (PMA); (8) Soyuz docking to the ISS; (9) the Transhab components; and (10) a complete ISS assembly. Live footage shows the construction of Zarya, the Proton rocket, Unity Node, PMA, Service Module, US Laboratory, Italian Multipurpose Logistics Module, US Airlock, and the US Habitation Module. STS-88 Mission Specialists Jerry Ross and James Newman are seen training in the Neutral Buoyancy Laboratory (NBL). The Expedition 1 crewmembers, William Shepherd, Yuri Gidzenko, and Sergei Krikalev, are shown training in the Black Sea and at Johnson Space Flight Center for water survival.

Relationship Between Carbon Dioxide Levels and Reported Congestion and Headaches on the International Space Station

NASA Technical Reports Server (NTRS)

Cole, Robert; Wear, Mary; Young, Millennia; Cobel, Christopher; Mason, Sara

2017-01-01

Congestion is commonly reported during spaceflight, and most crewmembers have reported using medications for congestion during International Space Station (ISS) missions. Although congestion has been attributed to fluid shifts during spaceflight, fluid status reaches equilibrium during the first week after launch while congestion continues to be reported throughout long duration missions. Congestion complaints have anecdotally been reported in relation to ISS CO2 levels; this evaluation was undertaken to determine whether or not an association exists. METHODS: Reported headaches, congestion symptoms, and CO2 levels were obtained for ISS expeditions 2-31, and time-weighted means and single-point maxima were determined for 24-hour (24hr) and 7-day (7d) periods prior to each weekly private medical conference. Multiple imputation addressed missing data, and logistic regression modeled the relationship between probability of reported event of congestion or headache and CO2 levels, adjusted for possible confounding covariates. The first seven days of spaceflight were not included to control for fluid shifts. Data were evaluated to determine the concentration of CO2 required to maintain the risk of congestion below 1% to allow for direct comparison with a previously published evaluation of CO2 concentrations and headache. RESULTS: This study confirmed a previously identified significant association between CO2 and headache and also found a significant association between CO2 and congestion. For each 1-mm Hg increase in CO2, the odds of a crew member reporting congestion doubled. The average 7-day CO2 would need to be maintained below 1.5 mmHg to keep the risk of congestion below 1%. The predicted probability curves of ISS headache and congestion curves appear parallel when plotted against ppCO2 levels with congestion occurring at approximately 1mmHg lower than a headache would be reported. DISCUSSION: While the cause of congestion is multifactorial, this study showed congestion is associated with CO2 levels on ISS. Data from additional expeditions could be incorporated to further assess this finding. CO2 levels are also associated with reports of headaches on ISS. While it may be expected for astronauts with congestion to also complain of headaches, these two symptoms are commonly mutually exclusive. Furthermore, it is unknown if a temporal CO2 relationship exists between congestion and headache on ISS. CO2 levels were time-weighted for 24hr and 7d, and thus the time course of congestion leading to headache was not assessed; however, congestion could be an early CO2-related symptom when compared to headache. Future studies evaluating the association of CO2-related congestion leading to headache would be difficult due to the relatively stable daily CO2 levels on ISS currently, but a systematic study could be implemented on-orbit if desired.

Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma.

PubMed

Terpos, Evangelos; Matsaridis, Dimitris; Koutoulidis, Vassilis; Zagouri, Flora; Christoulas, Dimitrios; Fontara, Sophia; Panourgias, Evangelia; Gavriatopoulou, Maria; Kastritis, Efstathios; Dimopoulos, Meletios A; Moulopoulos, Lia A

2017-10-01

The aim of the study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with newly diagnosed multiple myeloma (MM) who were treated with novel anti-myeloma agents. We studied 60 previously untreated MM patients at diagnosis, 14 with smoldering MM (SMM) and 5 with MGUS. All patients underwent MRI of the thoracolumbar spine and pelvis before the administration of any kind of therapy, and DCE-MRI was performed. The MRI perfusion parameters evaluated were wash-in (WIN), washout (WOUT), time-to-peak (TTPK), time-to-maximum slope (TMSP), and the WIN/TMSP ratio. The following serum levels of angiogenic cytokines were measured on the day of MRI: VEGF, angiogenin (Ang), angiopoietin-1 (Angp-1), and -2 (Angp-2). Symptomatic MM patients had increased WIN compared to SMM (p < 0.05) and MGUS patients (p = 0.001). TTPK was decreased, and WIN/TMSP was increased in both symptomatic and SMM patients compared to MGUS patients (p < 0.05). Symptomatic MM patients had decreased TMSP compared to MGUS patients. The Angp-1/Angp-2 ratio was reduced in symptomatic MM compared to SMM (p = 0.017) and MGUS patients (p < 0.001). TTPK correlated with Angp-1/Angp-2 ratio and importantly with R-ISS. Patients with R-ISS-3 had lower TTPK median value (23 s, range 18-29 s) compared to patients with R-ISS-2 (48 s, range 27-68 s) and patients with R-ISS-1 MM (54 s, range 42-76 s; p ANOVA = 0.01). A subset of patients with low TTPK (lower quartile) had shorter time to progression compared to all other patients. These data suggest that certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the ratio of Angp-1/Angp-2.

Fundamental Space Biology-1: HHR and Incubator for ISS Space Life Sciences

NASA Astrophysics Data System (ADS)

Kirven-Brooks, M.; Fahlen, T.; Sato, K.; Reiss-Bubenheim, D.

The Space Station Biological Research Project (SSBRP) is developing an Incubator and a Habitat Holding Rack (HHR) to support life science experiments aboard the International Space Station (ISS). The HHR provides for cooling and power needs, and supports data transfer (including telemetry, commanding, video processing, Ethernet), video compression, and data and command storage). The Incubator is a habitat that provides for controlled temperature between +4 C and +45 C and air circulation. It has a set of connector ports for power, analog and digital sensors, and video pass-through to support experiment-unique hardware within the Incubator specimen chamber. The Incubator exchanges air with the ISS cabin. The Fundamental Space Biology-1 (FSB-1) Project will be delivering, the HHR and two Incubators to ISS. The two inaugural experiments to be conducted on ISS using this hardware will investigate the biological effects of the space environment on two model organisms, Saccharomyces cerevisiae (S. cerevisiae; yeast) and Caenorhabditis elegans (C. elegans; nematode). The {M}odel {Y}east {C}ultures {o}n {S}tation (MYCOS) experiment will support examination of the effect of microgravity and cosmic radiation on yeast biology. In the second series of experiments during the same increment, the effects of microgravity and space environment radiation on C. elegans will be examined. The {F}undamental Space Biology {I}ncubator {E}xperiment {R}esearch using {C}. {e}legans (FIERCE) study is designed to support a long duration, multi-generational study of nematodes. FIERCE on-orbit science operations will include video monitoring, sub-culturing and periodic fixation and freezing of samples. For both experiments, investigators will be solicited via an International Space Life Sciences Research Announcement. In the near future, the Centrifuge Accommodation Module will be delivered to ISS, which will house the SSBRP 2.5 m Centrifuge Rotor. The Incubator can be placed onto the Centrifuge Rotor, which is capable of supporting variable gravity experiments from microgravity through 2g.

Intermittent Short Sleep Results in Lasting Sleep Wake Disturbances and Degeneration of Locus Coeruleus and Orexinergic Neurons

PubMed Central

Zhu, Yan; Fenik, Polina; Zhan, Guanxia; Somach, Rebecca; Xin, Ryan; Veasey, Sigrid

2016-01-01

Study Objectives: Intermittent short sleep (ISS) is pervasive among students and workers in modern societies, yet the lasting consequences of repeated short sleep on behavior and brain health are largely unexplored. Wake-activated neurons may be at increased risk of metabolic injury across sustained wakefulness. Methods: To examine the effects of ISS on wake-activated neurons and wake behavior, wild-type mice were randomized to ISS (a repeated pattern of short sleep on 3 consecutive days followed by 4 days of recovery sleep for 4 weeks) or rested control conditions. Subsets of both groups were allowed a recovery period consisting of 4-week unperturbed activity in home cages with littermates. Mice were examined for immediate and delayed (following recovery) effects of ISS on wake neuron cell metabolics, cell counts, and sleep/wake patterns. Results: ISS resulted in sustained disruption of sleep/wake activity, with increased wakefulness during the lights-on period and reduced wake bout duration and wake time during the lights-off period. Noradrenergic locus coeruleus (LC) and orexinergic neurons showed persistent alterations in morphology, and reductions in both neuronal stereological cell counts and fronto-cortical projections. Surviving wake-activated neurons evidenced persistent reductions in sirtuins 1 and 3 and increased lipofuscin. In contrast, ISS resulted in no lasting injury to the sleep-activated melanin concentrating hormone neurons. Conclusions: Collectively these findings demonstrate for the first time that ISS imparts significant lasting disturbances in sleep/wake activity, degeneration of wake-activated LC and orexinergic neurons, and lasting metabolic changes in remaining neurons most consistent with premature senescence. Citation: Zhu Y, Fenik P, Zhan G, Somach R, Xin R, Veasey S. Intermittent short sleep results in lasting sleep wake disturbances and degeneration of locus coeruleus and orexinergic neurons. SLEEP 2016;39(8):1601–1611. PMID:27306266

Comparison of Two Digital Stethoscopes with the Traditional Stethoscope Used on International Space Station

NASA Technical Reports Server (NTRS)

Rasbury, Jack; Bascal, Kira; Ownby, Matt; McCulley, Phyllis; Paul, Bonnie

2004-01-01

A traditional stethoscope is currently flown on the International Space Station (ISS). The background noise on the ISS is much higher than a normal exam room, and the literature shows that traditional stethoscopes are unable to function effectively in high noise environments. Digital stethoscopes provide amplification which improves the audibility in a quiet environment. This study is designed to determine if digital stethoscopes offer any advantage over traditional stethoscopes in being able to identify normal and abnormal sounds in the ISS noise environment. Methods: An ISS noise simulation facility was created to reproduce ISS noise profiles by modifying pink noise with a software-based graphic equalizer. The files were played in a continuous loop on a computer, amplified through a high-end stereo system and adjusted using a sound level meter. Nine caregiver analogues were given the same auscultation lesson received by astronauts. They began testing by becoming familiar with normal and abnormal sounds on a Student Auscultation Manikin . They then used two digital stethoscopes and a traditional stethoscope identical to the one flown on the ISS to auscultate the manikin sounds in the noise facility. They identified the sounds on a questionnaire and picked which of the three stethoscopes they preferred. Results: Evaluators displayed equivalent accuracy in sound identification when using either the 3M model 4000 digital stethoscope or traditional stethoscope. However, the 3M was preferred 2 to 1 by the evaluators, primarily because of additional amplification of the sounds. Discussion: Although our results show that the current ISS stethoscope and the "best-of-breed" digital stethoscope provide essentially the same auscultation utility, the latter has the advantage of recording and transmitting sounds to a remote physician. Since the astronaut caregivers are non-physiCians, this capability may be worth the additional expense and effort needed to certify the digital stethoscope for flight.

Lu plays with a droplet of liquid

NASA Image and Video Library

2003-10-25

ISS007-E-17985 (2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, watches a water bubble float between him and the camera, showing his image refracted, on the International Space Station (ISS).

International Space Station (ISS)

NASA Image and Video Library

1995-04-17

International Cooperation Phase III: A Space Shuttle docked to the International Space Station (ISS) in this computer generated representation of the ISS in its completed and fully operational state with elements from the U.S., Europe, Canada, Japan, and Russia.

Expedition Six Flight Engineer Donald R. Pettit is loading software on PC in U.S. Lab

NASA Image and Video Library

2002-12-06

ISS006-E-07133 (9 December 2002) --- Astronaut Donald R. Pettit, Expedition 6 NASA ISS science officer, works to set up Pulmonary Function in Flight (PuFF) hardware in preparation for a Human Research Facility (HRF) experiment in the Destiny laboratory on the International Space Station (ISS). Expedition 6 is the fourth and final expedition crew to perform the HRF/PuFF Experiment on the ISS.

Expedition Six Flight Engineer Donald R. Pettit is loading software on PC in U.S. Lab

NASA Image and Video Library

2002-12-06

ISS006-E-07134 (9 December 2002) --- Astronaut Donald R. Pettit, Expedition Six NASA ISS science officer, works to set up Pulmonary Function in Flight (PuFF) hardware in preparation for a Human Research Facility (HRF) experiment in the Destiny laboratory on the International Space Station (ISS). Expedition Six is the fourth and final expedition crew to perform the HRF/PuFF Experiment on the ISS.

STS-106 ISS Overview Briefing

NASA Technical Reports Server (NTRS)

2000-01-01

Dwayne Brown, NASA Public Affairs, introduces Bob Cabana of NASA, Mikhail Sinelshikov of PKA, Vasily Tsibliev of GCTC, Steve Mozes of CSA, Ian Pryke of ESA, and Masaaki Komatsu of NASDA. Each man gives an overview of the status of the International Space Station (ISS), including details on the current configuration, future missions and what they will bring to the ISS, and each space agency's contribution to the ISS. They then answer questions from the press.

ISS Expedition 42 / 43 Crew Training Resource Reel (JSC-2641)

NASA Image and Video Library

2014-11-14

Media resource reel of ISS Expedition 42 / 43 Crew training activities. Includes footage of crew photo shots with Samantha Cristoforetti, Anton Shkaplerov and Terry Virts; Routine shots with Virts, ISS Expedition 43 crewmember Scott Kelly, Cristoforetti, ISS Expedition 41 / 42 crewmember Barry Wilmore; and Shklaplerov; T-38 Operations with Virts; Routine operations with Cristoforetti, Shkaplerov and Virts; Neutral Buoyancy Lab (NBL) with Cristoforetti and Kelly; and Emergency Scenatios with Virts, Cristoforetti and Shkaplerov.

International Space Station (ISS)

NASA Image and Video Library

2001-05-14

Astronaut James S. Voss, Expedition Two flight engineer, works with a series of cables on the EXPRESS Rack in the United State's Destiny laboratory on the International Space Station (ISS). The EXPRESS Rack is a standardized payload rack system that transports, stores, and supports experiments aboard the ISS. EXPRESS stands for EXpedite the PRocessing of Experiments to the Space Station, reflecting the fact that this system was developed specifically to maximize the Station's research capabilities. The EXPRESS Rack system supports science payloads in several disciplines, including biology, chemistry, physics, ecology, and medicine. With the EXPRESS Rack, getting experiments to space has never been easier or more affordable. With its standardized hardware interfaces and streamlined approach, the EXPRESS Rack enables quick, simple integration of multiple payloads aboard the ISS. The system is comprised of elements that remain on the ISS, as well as elements that travel back and forth between the ISS and Earth via the Space Shuttle.

Progress in Spacecraft Environment Interactions: International Space Station (ISS) Development and Operations

NASA Technical Reports Server (NTRS)

Koontz, Steve; Suggs, Robb; Schneider, Todd; Minow, Joe; Alred, John; Cooke, Bill; Mikatarian, Ron; Kramer, Leonard; Boeder, paul; Soares, Carlos

2007-01-01

The set of spacecraft interactions with the space flight environment that have produced the largest impacts on the design, verification, and operation of the International Space Station (ISS) Program during the May 2000 to May 2007 time frame are the focus of this paper. In-flight data, flight crew observations, and the results of ground-based test and analysis directly supporting programmatic and operational decision-making are reported as are the analysis and simulation efforts that have led to new knowledge and capabilities supporting current and future space explorations programs. The specific spacecraft-environment interactions that have had the greatest impact on ISS Program activities during the first several years of flight are: 1) spacecraft charging, 2) micrometeoroids and orbital debris effects, 3) ionizing radiation (both total dose to materials and single event effects [SEE] on avionics), 4) hypergolic rocket engine plume impingement effects, 5) venting/dumping of liquids, 6) spacecraft contamination effects, 7) neutral atmosphere and atomic oxygen effects, 8) satellite drag effects, and 9) solar ultraviolet effects. Orbital inclination (51.6deg) and altitude (nominally between 350 km and 460 km) determine the set of natural environment factors affecting the performance and reliability of materials and systems on ISS. ISS operates in the F2 region of Earth s ionosphere in well-defined fluxes of atomic oxygen, other ionospheric plasma species, solar UV, VUV, and x-ray radiation as well as galactic cosmic rays, trapped radiation, and solar cosmic rays. The micrometeoroid and orbital debris environment is an important determinant of spacecraft design and operations in any orbital inclination. The induced environment results from ISS interactions with the natural environment as well as environmental factors produced by ISS itself and visiting vehicles. Examples include ram-wake effects, hypergolic thruster plume impingement, materials out-gassing, venting and dumping of fluids, and specific photovoltaic (PV) power system interactions with the ionospheric plasma. Vehicle size (L) and velocity (v), combined with the magnitude and direction of the geomagnetic field (B) produce operationally significant magnetic induction voltages (VxB.L) in ISS conducting structure during high latitude flight (>+/- 45deg) during each orbit. In addition, ISS is a large vehicle and produces a deep wake structure from which both ionospheric plasma and neutrals species are largely excluded. ISS must fly in a very limited number of approved flight attitudes, so that exposure of a particular material or system to environmental factors depends upon: 1) location on ISS, 2) ISS flight configuration, 3) ISS flight attitude, and 4) variation of solar exposure (Beta angle), and hence thermal environment, with time. Finally, an induced ionizing radiation environment is produced by trapped radiation and solar/cosmic ray interactions with the relatively massive ISS structural shielding.

Role of the Space Station in Private Development of Space

NASA Astrophysics Data System (ADS)

Uhran, M. L.

2002-01-01

The International Space Station (ISS) is well underway in the assembly process and progressing toward completion. In February 2001, the United States laboratory "Destiny" was successfully deployed and the course of space utilization, for laboratory-based research and development (R&D) purposes, entered a new era - continuous on-orbit operations. By completion, the ISS complex will include pressurized laboratory elements from Europe, Japan, Russia and the U.S., as well as external platforms which can serve as observatories and technology development test beds serviced by a Canadian robotic manipulator. The international vision for a continuously operating, full service R&D complex in the unique environment of low-Earth orbit is becoming increasingly focused. This R&D complex will offer great opportunities for economic return as the basic research program proceeds on a global scale and the competitive advantages of the microgravity and ultravacuum environments are elucidated through empirical studies. In parallel, the ISS offers a new vantage point, both as a source for viewing of Earth and the Cosmos and as the subject of view for a global population that has grown during the dawning of the space age. In this regard, the ISS is both a working laboratory and a powerful symbol for human achievement in science and technology. Each of these aspects bears consideration as we seek to develop the beneficial attributes of space and pursue innovative approaches to expanding this space complex through private investment. Ultimately, the success of the ISS will be measured by the outcome at the end of its design lifetime. Will this incredible complex be de-orbited in a fiery finale, as have previous space platforms? Will another, perhaps still larger, space station be built through global government funding? Will the ISS ownership be transferred to a global, non-government organization for refurbishment and continuation of the mission on a privately financed basis? Steps taken by the ISS partnership today will effect the later outcome. This paper reviews the range of activities underway in the U.S., as well those being pursued on a multilateral basis across the partnership. It will report on the status of NASA planning for establishment of a non-governmental organization (NGO) to manage the U.S. share of ISS user resources and accommodations. This initiative is unprecedented for a human-rated space craft of ISS magnitude and represents an extraordinarily complex undertaking due to the multi-mission, multi-partner nature of the program. Nonetheless, major advances are scheduled for 2002, as a new NASA Administrator takes the helm and declares the study phase is over. On the global front, the ISS Partners have formed a Multilateral Commercialization Group (MCG) charged to develop Recommended Guidelines for ISS Commercial Activities. Areas such as advertising, merchandising, entertainment, and sponsorship are actively under consideration with plans to advance to the long-awaited decision phase. In conjunction with this project, the challenging issue of how to create, protect, and potentially market the ISS brand to the benefit of the Partners, as well as the scientific, technological and commercial users of the station, is approaching resolution. In the area of space product development, the NASA Commercial Space Centers are entering the era of the space station with new operating principles and practices that promise a focused and sustainable research and development program. This portfolio of seventeen cooperative agreements spans applications in biotechnology, agriculture, remote sensing, and advanced materials. The rate-limiting step has long been access to space and we now stand ready to seize the opportunities afforded by a continuously operating, full-service laboratory in orbit. Each of these initiatives will have a marked effect on evolution of the space station program from a commercial development perspective and each offers the potential to open up economic development of low-Earth orbit in the first half of the 21st century.

Benefits of International Collaboration on the International Space Station

NASA Technical Reports Server (NTRS)

Robinson, Julie A.; Hasbrook, Pete; Tate Brown, Judy; Thumm, Tracy; Cohen, Luchino; Marcil, Isabelle; De Parolis, Lina; Hatton, Jason; Umezawa, Kazuo; Shirakawa, Masaki;

Orthostatic Hypotension After Long-Duration Space Flight: NASA's Experiences from the International Space Station

NASA Technical Reports Server (NTRS)

Lee, Stuart M. C.; Feiveson, Alan H.; Stenger, Michael B.; Stein, Sydney P.; Platts, Steven H.

2011-01-01

Our laboratory previously reported that the incidence of orthostatic hypotension (OH) was greater after long- than short-duration spaceflight in astronauts who participated in Mir Space Station and Space Shuttle missions. To confirm and extend these findings, we retrospectively examined tilt test data from International Space Station (ISS) and Shuttle astronauts. We anticipated that the proportion of ISS astronauts experiencing OH would be high on landing day and the number of days to recover greater after long- than short-duration missions. Methods: Twenty ISS and 66 Shuttle astronauts participated in 10-min 80? head-up tilt tests 10 d before launch (L-10), on landing day (R+0) or 1 d after landing (R+1). Data from 5 ISS astronauts tested on R+0 or R+1 who used non-standard countermeasures were excluded. Many astronauts repeated the test 3 d (R+3) after landing. Fisher?s Exact Test was used to compare the ability of ISS and Shuttle astronauts to complete the tilt test on R+0. Cox regression was used to identify cardiovascular parameters that were associated with test completion across all tests, and mixed model analysis was used to compare the change and recovery rates between ISS and Shuttle astronauts. In these analyses, ISS data from R+0 and R+1 were pooled to provide sufficient statistical power. Results: The proportion of astronauts who completed the tilt test on R+0 without OH was less in ISS than in Shuttle astronauts (p=0.03). On R+0, only 2 of 6 ISS astronauts completed the test compared to 53 of 66 (80%) Shuttle astronauts. However, 8 of 9 ISS astronauts completed the test on R+1. On R+3, 13 of 15 (87%) of the ISS and 19 of 19 (100%) of the Shuttle astronauts completed the 10-min test. An index comprised of stroke volume and diastolic blood pressure provided a very good prediction of overall tilt survival. This index was altered by spaceflight similarly for both groups soon after landing (pooled R+0 and R+ 1), but ISS astronauts did not recover at the same rate as Shuttle astronauts (p=0.007). Conclusions: The proportion of ISS astronauts who could not complete the tilt test on R+0 due to OH (4 of 6) is similar to that reported in astronauts who flew on Mir (5 of 6). Further, cardiovascular parameters most closely associated with OH recover more slowly after long- compared to short-duration spaceflight.

NUTRITION w/Repository

NASA Image and Video Library

2009-06-06

ISS020-E-007566 (6 June 2009) --- European Space Agency astronaut Frank De Winne, Expedition 20 flight engineer, prepares to put samples in the Minus Eighty Laboratory Freezer for ISS (MELFI) in the Kibo laboratory of the International Space Station. Samples were taken as part of the Nutritional Status Assessment (Nutrition) with Repository experiment, a study done by NASA to date of human physiologic changes during long-duration spaceflight.

Training Information Service Specialists in the Less-Favoured Regions of the European Union (TRAIN-ISS): The Diploma/MSc Programme at the University of Sheffield.

ERIC Educational Resources Information Center

Owens, Ian; And Others

1997-01-01

The primary aim of the training information specialists (TRAIN-ISS) program at the University of Sheffield's Department of Information Studies was to train information service specialists from the less favored regions of the European Union. Describes the course design; selection of participants; student assessment, support, and placement; program…

Long-term changes in the density and structure of the human hip and spine after long-duration spaceflight

NASA Astrophysics Data System (ADS)

Dana Carpenter, R.; LeBlanc, Adrian D.; Evans, Harlan; Sibonga, Jean D.; Lang, Thomas F.

2010-07-01

To determine the long-term effects of long-duration spaceflight, we measured bone mineral density and bone geometry of International Space Station (ISS) crewmembers using quantitative computed tomography (QCT) before launch, immediately upon their return, one year after return, and 2-4.5 years after return from the ISS. Eight crew members (7 male, 1 female, mean age 45±4 years at start of mission) who spent an average of 181 days (range 161-196 days) aboard the ISS took part in the study. Integral bone mineral density (iBMD), trabecular BMD (tBMD), bone mineral content (BMC), and vertebral cross-sectional area (CSA) were measured in the lumbar spine, and iBMD, tBMD, cortical BMD (cBMD), BMC, CSA, volume, and femoral neck section modulus were measured in the hip. Spine iBMD was 95% of the average preflight value upon return from the ISS and reached its preflight value over the next 2-4.5 years. Spine tBMD was 97% of the average preflight value upon return from the ISS and tended to decrease throughout the course of the study. Vertebral CSA remained essentially unchanged throughout the study. Hip iBMD was 91% of the preflight value upon return from the ISS and was 95% of the preflight value after 2-4.5 years of recovery. Hip tBMD was 88% of the preflight value upon return and recovered to only 93% of the preflight value after 1 year. At the 2- to 4.5-year time point, average tBMD was 88% of the preflight value. During the recovery period the total volume and cortical bone volume in the hip reached values of 114% and 110% of their preflight values, respectively. The combination of age-related bone loss, long-duration spaceflight, and re-adaptation to the 1-g terrestrial environment presumably produced these changes. These long-term data suggest that skeletal changes that occur during long-duration spaceflight persist even after multiple years of recovery. These changes have important implications for the skeletal health of crew members, especially those who make repeat trips to space.

Requirements, Resource Planning and Management for Decrewing/Recrewing Scenarios of the International Space Station

NASA Technical Reports Server (NTRS)

Bach, David A.; Hasbrook, Peter V.; BBrand, Susan N.

2012-01-01

Following the failure of 44P on launch in August 2011, and the subsequent grounding of all Russian Soyuz rocket based launches, the ISS ground teams engaged in an effort to determine how long the ISS could remain crewed, what would be required to safely configure the ISS for decrewing, and what would be required to recrew the ISS upon resumption of Soyuz rocket launches if decrewing became necessary. This White Paper was written to capture the processes and lessons learned from real-time time events and to provide a reference and training document for ISS Program teams in the event decrewing of the ISS is needed. Through coordination meetings and assessments, teams identified six decrewing priorities for ground and crew operations. These priorities were integrated along with preflight priorities through the Increment replanning process. Additionally, the teams reviewed, updated, and implemented changes to the governing documentation for the configuration of the ISS for a contingency decrewing event. Steps were taken to identify critical items for disposal prior to decrewing, as well as identifying the required items to be strategically staged or flown with the astronauts and cosmonauts who would eventually recrew the ISS. After the successful launches and dockings of both 45P and 28S, the decrewing team transitioned to finalizing and publishing the documentation for standardizing the decrewing flight rules. With the continued launching of crews and cargo to the ISS, utilization and science is again a high priority, with the Increment pairs 29 and 30, and 31 and 32 reaching the milestone of at least 35 hours per week average utilization.

ISS Utilization for Exploration-Class Missions

NASA Technical Reports Server (NTRS)

FIncke, R.; Davis-Street, J.; Korth, D.

2006-01-01

Exercise countermeasures are the most commonly utilized approach for maintaining the health and performance of astronauts during spaceflight missions. However, International Space Station (ISS) exercise countermeasure hardware reliability and prescriptions are not at a point of departure to support exploration-class missions. The JSC Exercise Countermeasures Project (ECP) plans to use ISS as a research and hardware evaluation platform to define and validate improved exercise hardware, prescriptions, and monitoring strategies to support crewmember operations on the Moon and Mars. The ECP will partner with JSC's Space Medicine Division to standardize elements of ISS exercise prescriptions to better understand their efficacy and to propose modified prescriptions for implementation that may be used in the crew exploration vehicle and/or lunar habitat. In addition, evaluations of the ISS treadmill harness will be conducted to define and improve fit and function, and assess the next generation medical monitoring devices such as the portable unit for metabolic analysis and the muscle atrophy research and exercise system for completion of periodic fitness evaluations during lunar and Mars travel. Finally, biomechanical data from ISS crew exercise sessions will be obtained to better understand loading and restraint systems, and identify the physiologic requirements during ISS extravehicular activities that may be analogous to extended excursions from the lunar habitat. It is essential to optimize exercise prescriptions, hardware, and monitoring strategies for exploration initiatives using ISS as a platform before the planned retirement of the Shuttle in 2010 and the declining NASA emphasis on ISS to maximize knowledge before embarking on travel to the Moon and Mars.

Summary of 2006 to 2010 FPMU Measurements of International Space Station Frame Potential Variations

NASA Technical Reports Server (NTRS)

Minow, Joseph I.; Wright, Kenneth H., Jr.; Chandler, Michael O.; Coffey, Victoria N.; Craven, Paul D.; Schneider, Todd A.; Parker, Linda N.; Ferguson, Dale C.; Koontz, Steve L.; Alred, John W.

2010-01-01

Electric potential variations on the International Space Station (ISS) structure in low Earth orbit are dominated by contributions from interactions of the United States (US) 160 volt solar arrays with the relatively high density, low temperature plasma environment and inductive potentials generated by motion of the large vehicle across the Earth?s magnetic field. The Floating Potential Measurement Unit (FPMU) instrument suite comprising two Langmuir probes, a plasma impedance probe, and a floating potential probe was deployed in August 2006 for use in characterizing variations in ISS potential, the state of the ionosphere along the ISS orbit and its effect on ISS charging, evaluating effects of payloads and visiting vehicles, and for supporting ISS plasma hazard assessments. This presentation summarizes observations of ISS frame potential variations obtained from the FPMU from deployment in 2006 through the current time. We first describe ISS potential variations due to current collection by solar arrays in the day time sector of the orbit including eclipse exit and entry charging events, potential variations due to plasma environment variations in the equatorial anomaly, and visiting vehicles docked to the ISS structure. Next, we discuss potential variations due to inductive electric fields generated by motion of the vehicle across the geomagnetic field and the effects of external electric fields in the ionosphere. Examples of night time potential variations at high latitudes and their possible relationship to auroral charging are described and, finally, we demonstrate effects on the ISS potential due to European Space Agency and US plasma contactor devices.

High dose rates obtained outside ISS in June 2015 during SEP event

NASA Astrophysics Data System (ADS)

Dachev, T. P.; Tomov, B. T.; Matviichuk, Yu. N.; Dimitrov, Pl. G.; Bankov, N. G.

2016-06-01

The R3DR2 instrument performed measurements in the European Space Agency (ESA) EXPOSE-R2 platform outside the Russian "Zvezda" module of the International Space Station (ISS) in the period 24 October 2014-11 January 2016. It is the Liulin-type deposited energy spectrometer (DES) (Dachev et al., 2015a). Took place in November 2014, this was the first attempt to monitor a small solar energetic particle (SEP) event outside ISS using the Liulin-type DES (Dachev et al., 2015d). In this study, we describe the dosimetric characteristics of the largest SEP event, observed on 22 June 2015 with the R3DR2 instrument outside ISS. The main finding of this study is that SEP protons with a minimum energy of approximately 7 MeV at the surface of the R3DR2 detector produced high dose rates, reaching >5000 μGy h-1, while the inner radiation belt maximum dose was at the level of 2200 μGy h-1. If a virtual external vehicle activity (EVA) was performed in the same period of the SEP maximum on 22 June 2015, the doses obtained in the skin of cosmonauts/astronauts can reach 2.84 mGy after 6.5 h, which is similar to the average absorbed dose inside ISS for 15 days (Reitz et al., 2005). A comparison with other extreme events measured with Liulin-type instruments shows that SEPs similar to that observed on 22 June 2015 could be one of the most dangerous events for the cosmonauts/astronauts involved in EVA.

A Survey of Staphylococcus sp and its Methicillin Resistance aboard the International Space Station

NASA Technical Reports Server (NTRS)

Bassinger, V. J.; Fontenot, S. L.; Castro, V. A.; Ott, C.; Healy, M.; Pierson, D. L.

2004-01-01

Background: Within the past few years, methicillin-resistant Staphylococcus aureus has emerged in environments with susceptible hosts in close proximity, such as hospitals and nursing homes. As the International Space Station (ISS) represents a semi-closed environment with a high level of crewmember interaction, an evaluation of isolates of clinical and environmental Staphylococcus aureus and coagulase negative Staphylococcus was performed to determine if this trend was also present in astronauts occupying ISS or on surfaces of the space station itself. Methods: Identification of isolates was completed using VITEK (GPI cards, BioMerieux), 16S ribosomal DNA analysis (MicroSeq 500, ABI), and Rep-PCR DNA fingerprinting (Divemilab, Bacterial Barcodes). Susceptibility tests were performed using VITEK (GPS-105 cards, BioMerieux) and resistance characteristics were evaluated by testing for the presence of the mecA gene (PBP2' MRSA test kit, Oxoid). Results: Rep-PCR analysis indicated the transfer of S. aureus between crewmembers and between crewmembers and ISS surfaces. While a variety of S. aureus were identified from both the crewmembers and environment, evaluations of the microbial population indicated minimal methicillin resistance. Results of this study indicated that within the semi-closed ISS environment, transfer of bacteria between crewmembers and their environment has been occurring, although there was no indication of a high concentration of methicillin resistant Staphylococcus species. Conclusions: While this study suggests that the spread of methicillin resistant S. aureus is not currently a concern aboard ISS, the increasing incidence of Earth-based antibiotic resistance indicates a need for continued clinical and environmental monitoring.

Pettit works at the HRF workstation in Destiny during Expedition Six

NASA Image and Video Library

2003-01-02

ISS006-E-13995 (2 January 2003) --- Astronaut Donald R. Pettit, Expedition Six NASA ISS science officer, performs the Human Research Facility (HRF) Ultrasound functional checkout in the Destiny laboratory on the International Space Station (ISS).

Benefits of International Collaboration on the International Space Station

NASA Technical Reports Server (NTRS)

Hasbrook, Pete; Robinson, Julie A.; Brown Tate, Judy; Thumm, Tracy; Cohen, Luchino; Marcil, Isabelle; De Parolis, Lina; Hatton, Jason; Umezawa, Kazuo; Shirakawa, Masaki;

Expanding NASA and Roscosmos Scientific Collaboration on the International Space Station

NASA Technical Reports Server (NTRS)

Hasbrook, Pete

2016-01-01

The International Space Station (ISS) is a world-class laboratory orbiting in space. NASA and Roscosmos have developed a strong relationship through the ISS Program Partnership, working together and with the other ISS Partners for more than twenty years. Since 2013, based on a framework agreement between the Program Managers, NASA and Roscosmos are building a joint program of collaborative research on ISS. This international collaboration is developed and implemented in phases. Initially, members of the ISS Program Science Forum from NASA and TsNIIMash (representing Roscosmos) identified the first set of NASA experiments that could be implemented in the "near term". The experiments represented the research categories of Technology Demonstration, Microbiology, and Education. Through these experiments, the teams from the "program" and "operations" communities learned to work together to identify collaboration opportunities, establish agreements, and jointly plan and execute the experiments. The first joint scientific activity on ISS occurred in January 2014, and implementation of these joint experiments continues through present ISS operations. NASA and TsNIIMash have proceeded to develop "medium term" collaborations, where scientists join together to improve already-proposed experiments. A major success is the joint One-Year Mission on ISS, with astronaut Scott Kelly and cosmonaut Mikhail Kornienko, who returned from ISS in March, 2016. The teams from the NASA Human Research Program and the RAS Institute for Biomedical Problems built on their considerable experience to design joint experiments, learn to work with each other's protocols and processes, and share medical and research data. New collaborations are being developed between American and Russian scientists in complex fluids, robotics, rodent research and space biology, and additional human research. Collaborations are also being developed in Earth Remote Sensing, where scientists will share data from imaging systems mounted on ISS as well as other orbiting spacecraft to improve our understanding of the Earth and its climate. NASA and Roscosmos continue to encourage international scientific cooperation and expanded use of the ISS Laboratory. "Long-term", larger collaborations will achieve scientific objectives that no single national science team or agency can achieve on its own. The joint accomplishments achieved so far have paved the way for a stronger international scientific community and improved results and benefits from ISS.

The International Space Station and the Space Debris Environment: 10 Years On

NASA Technical Reports Server (NTRS)

Johnson, Nicholas; Klinkrad, Heiner

2009-01-01

For just over a decade the International Space Station (ISS), the most heavily protected vehicle in Earth orbit, has weathered the space debris environment well. Numerous hypervelocity impact features on the surface of ISS caused by small orbital debris and meteoroids have been observed. In addition to typical impacts seen on the large solar arrays, craters have been discovered on windows, hand rails, thermal blankets, radiators, and even a visiting logistics module. None of these impacts have resulted in any degradation of the operation or mission of the ISS. Validating the rate of small particle impacts on the ISS as predicted by space debris environment models is extremely complex. First, the ISS has been an evolving structure, from its original 20 metric tons to nearly 300 metric tons (excluding logistics vehicles) ten years later. Hence, the anticipated space debris impact rate has grown with the increasing size of ISS. Secondly, a comprehensive visual or photographic examination of the complete exterior of ISS has never been accomplished. In fact, most impact features have been discovered serendipitously. Further complications include the estimation of the size of an impacting particle without knowing its mass, velocity, and angle of impact and the effect of shadowing by some ISS components. Inadvertently and deliberately, the ISS has also been the source of space debris. The U.S. Space Surveillance Network officially cataloged 65 debris from ISS from November 1998 to November 2008: from lost cameras, sockets, and tool bags to intentionally discarded equipment and an old space suit. Fortunately, the majority of these objects fall back to Earth quickly with an average orbital lifetime of less than two months and a maximum orbital lifetime of a little more than 15 months. The cumulative total number of debris object-years is almost exactly 10, the equivalent of one piece of debris remaining in orbit for 10 years. An unknown number of debris too small to be tracked and cataloged have also been generated, but normally with even shorter orbital lifetimes. Finally, eight collision avoidance maneuvers have been performed to avoid potential collisions between ISS and large, tracked space debris. The most recent such maneuver was accomplished by ESA's Automated Transfer Vehicle, the Jules Verne, just three months before the 10th anniversary of the launch of ISS's first element.

STS-111 Crew Interviews: Ken Cockrell, Commander

NASA Technical Reports Server (NTRS)

2002-01-01

STS-111 Mission Commander Ken Cockrell is seen during this preflight interview, answering questions about his inspiration in becoming an astronaut and provides an overview of the mission. He discusses the following topics: the docking of the Endeavour Orbiter to the International Space Station (ISS), the delivery of the Mobile Base System (MBS) to the ISS, the crew transfer activities (the Expedition 5 crew is replacing the Expedition 4 crew on the ISS), the planned extravehicular activities (EVAs), and the installation of the MBS onto the ISS. Cockrell provides a detailed description of the MBS and its significance for the ISS. He also describes prelaunch activities, mission training and international cooperation during the mission.

Sorting variables for each case: a new algorithm to calculate injury severity score (ISS) using SPSS-PC.

PubMed

Linn, S

One of the more often used measures of multiple injuries is the injury severity score (ISS). Determination of the ISS is based on the abbreviated injury scale (AIS). This paper suggests a new algorithm to sort the AISs for each case and calculate ISS. The program uses unsorted abbreviated injury scale (AIS) levels for each case and rearranges them in descending order. The first three sorted AISs representing the three most severe injuries of a person are then used to calculate injury severity score (ISS). This algorithm should be useful for analyses of clusters of injuries especially when more patients have multiple injuries.

ISS Crew Transportation and Services Requirements Document

NASA Technical Reports Server (NTRS)

Lueders, Kathryn L. (Compiler)

2015-01-01

Under the guidance of processes provided by Crew Transportation Plan (CCT-PLN-1100), this document with its sister documents, Crew Transportation Technical Management Processes (CCT-PLN-1120), Crew Transportation Technical Standards and Design Evaluation Criteria (CCT-STD-1140), and Crew Transportation Operations Standards (CCT-STD-1150), and International Space Station (ISS) to Commercial Orbital Transportation Services Interface Requirements Document (SSP 50808), provides the basis for a National Aeronautics and Space Administration (NASA) certification for services to the ISS for the Commercial Provider. When NASA Crew Transportation System (CTS) certification is achieved for ISS transportation, the Commercial Provider will be eligible to provide services to and from the ISS during the services phase of the NASA Commercial Crew Program (CCP).

International Space Station (ISS)

NASA Image and Video Library

1998-01-01

This artist's concept depicts the completely assembled International Space Station (ISS) passing over the Straits of Gibraltar and the Mediterranean Sea. As a gateway to permanent human presence in space, the Space Station Program is to expand knowledge benefiting all people and nations. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide unprecedented undertakings in scientific, technological, and international experimentation. Experiments to be conducted in the ISS include: microgravity research, Earth science, space science, life sciences, space product development, and engineering research and technology. The sixteen countries participating the ISS are: United States, Russian Federation, Canada, Japan, United Kingdom, Germany, Italy, France, Norway, Netherlands, Belgium, Spain, Denmark, Sweden, Switzerland, and Brazil.

General Purpose Data-Driven Monitoring for Space Operations

NASA Technical Reports Server (NTRS)

Iverson, David L.; Martin, Rodney A.; Schwabacher, Mark A.; Spirkovska, Liljana; Taylor, William McCaa; Castle, Joseph P.; Mackey, Ryan M.

2009-01-01

As modern space propulsion and exploration systems improve in capability and efficiency, their designs are becoming increasingly sophisticated and complex. Determining the health state of these systems, using traditional parameter limit checking, model-based, or rule-based methods, is becoming more difficult as the number of sensors and component interactions grow. Data-driven monitoring techniques have been developed to address these issues by analyzing system operations data to automatically characterize normal system behavior. System health can be monitored by comparing real-time operating data with these nominal characterizations, providing detection of anomalous data signatures indicative of system faults or failures. The Inductive Monitoring System (IMS) is a data-driven system health monitoring software tool that has been successfully applied to several aerospace applications. IMS uses a data mining technique called clustering to analyze archived system data and characterize normal interactions between parameters. The scope of IMS based data-driven monitoring applications continues to expand with current development activities. Successful IMS deployment in the International Space Station (ISS) flight control room to monitor ISS attitude control systems has led to applications in other ISS flight control disciplines, such as thermal control. It has also generated interest in data-driven monitoring capability for Constellation, NASA's program to replace the Space Shuttle with new launch vehicles and spacecraft capable of returning astronauts to the moon, and then on to Mars. Several projects are currently underway to evaluate and mature the IMS technology and complementary tools for use in the Constellation program. These include an experiment on board the Air Force TacSat-3 satellite, and ground systems monitoring for NASA's Ares I-X and Ares I launch vehicles. The TacSat-3 Vehicle System Management (TVSM) project is a software experiment to integrate fault and anomaly detection algorithms and diagnosis tools with executive and adaptive planning functions contained in the flight software on-board the Air Force Research Laboratory TacSat-3 satellite. The TVSM software package will be uploaded after launch to monitor spacecraft subsystems such as power and guidance, navigation, and control (GN&C). It will analyze data in real-time to demonstrate detection of faults and unusual conditions, diagnose problems, and react to threats to spacecraft health and mission goals. The experiment will demonstrate the feasibility and effectiveness of integrated system health management (ISHM) technologies with both ground and on-board experiments.

Duque works at the MSG for PromISS 2 in the Lab during Expedition Seven / 8 OPS

NASA Image and Video Library

2003-10-27

ISS008-E-05026 (27 October 2003) --- European Space Agency (ESA) astronaut Pedro Duque (left) of Spain works with the Cervantes mission experiment PROMISS in the Microgravity Science Glovebox (MSG) in the Destiny laboratory on the International Space Station (ISS). This experiment will investigate the growth processes of proteins in weightless conditions. Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, is visible at right.

Advancing scoping study methodology: a web-based survey and consultation of perceptions on terminology, definition and methodological steps.

PubMed

O'Brien, Kelly K; Colquhoun, Heather; Levac, Danielle; Baxter, Larry; Tricco, Andrea C; Straus, Sharon; Wickerson, Lisa; Nayar, Ayesha; Moher, David; O'Malley, Lisa

2016-07-26

Scoping studies (or reviews) are a method used to comprehensively map evidence across a range of study designs in an area, with the aim of informing future research practice, programs and policy. However, no universal agreement exists on terminology, definition or methodological steps. Our aim was to understand the experiences of, and considerations for conducting scoping studies from the perspective of academic and community partners. Primary objectives were to 1) describe experiences conducting scoping studies including strengths and challenges; and 2) describe perspectives on terminology, definition, and methodological steps. We conducted a cross-sectional web-based survey with clinicians, educators, researchers, knowledge users, representatives from community-based organizations, graduate students, and policy stakeholders with experience and/or interest in conducting scoping studies to gain an understanding of experiences and perspectives on the conduct and reporting of scoping studies. We administered an electronic self-reported questionnaire comprised of 22 items related to experiences with scoping studies, strengths and challenges, opinions on terminology, and methodological steps. We analyzed questionnaire data using descriptive statistics and content analytical techniques. Survey results were discussed during a multi-stakeholder consultation to identify key considerations in the conduct and reporting of scoping studies. Of the 83 invitations, 54 individuals (65 %) completed the scoping questionnaire, and 48 (58 %) attended the scoping study meeting from Canada, the United Kingdom and United States. Many scoping study strengths were dually identified as challenges including breadth of scope, and iterative process. No consensus on terminology emerged, however key defining features that comprised a working definition of scoping studies included the exploratory mapping of literature in a field; iterative process, inclusion of grey literature; no quality assessment of included studies, and an optional consultation phase. We offer considerations for the conduct and reporting of scoping studies for researchers, clinicians and knowledge users engaging in this methodology. Lack of consensus on scoping terminology, definition and methodological steps persists. Reasons for this may be attributed to diversity of disciplines adopting this methodology for differing purposes. Further work is needed to establish guidelines on the reporting and methodological quality assessment of scoping studies.

Development of the Second Generation International Space Station (ISS) Total Organic Carbon Analyzer (TOCA)

NASA Technical Reports Server (NTRS)

Clements, Anna L.; Stinson, Richard G.; VanWie, Michael; Warren, Eric

2009-01-01

The second generation International Space Station (ISS) Total Organic Carbon Analyzer s (TOCA) function is to monitor concentrations of Total Organic Carbon (TOC) in ISS water samples. TOC is one measurement that provides a general indication of overall water quality by indicating the potential presence of hazardous chemicals. The data generated from the TOCA is used as a hazard control to assess the quality of the reclaimed and stored water supplies on-orbit and their suitability for crew consumption. This paper details the unique ISS Program requirements, the design of the ISS TOCA, and a brief description of the on-orbit concept-of-operations. The TOCA schematic will be discussed in detail along with specific information regarding key components. The ISS TOCA was designed as a non-toxic TOC analyzer that could be deployed in a flight ready package. This basic concept was developed through laboratory component level testing, two moderate fidelity integrated system breadboard prototypes, a flight-like full scale prototype, as well as lessons learned from the inadequacies of the first unit. The result: a new TOCA unit that is robust in design and includes special considerations to microgravity and the on-orbit ISS environment. TOCA meets the accuracy needs of the ISS Program with a 1,000 to 25,000 g/L range, accurate to within +/-25%.

An overview of NASA ISS human engineering and habitability: past, present, and future.

PubMed

Fitts, D; Architecture, B

2000-09-01

The International Space Station (ISS) is the first major NASA project to provide human engineering an equal system engineering an equal system engineering status to other disciplines. The incorporation and verification of hundreds of human engineering requirements applied across-the-board to the ISS has provided for a notably more habitable environment to support long duration spaceflight missions than might otherwise have been the case. As the ISS begins to be inhabited and become operational, much work remains in monitoring the effectiveness of the Station's built environment in supporting the range of activities required of a long-duration vehicle. With international partner participation, NASA's ISS Operational Habitability Assessment intends to carry human engineering and habitability considerations into the next phase of the ISS Program with constant attention to opportunities for cost-effective improvements that need to be and can be made to the on-orbit facility. Too, during its operations the ISS must be effectively used as an on-orbit laboratory to promote and expand human engineering/habitability awareness and knowledge to support the international space faring community with the data needed to develop future space vehicles for long-duration missions. As future space mission duration increases, the rise in importance of habitation issues make it imperative that lessons are captured from the experience of human engineering's incorporation into the ISS Program and applied to future NASA programmatic processes.

The European Astronaut Centre prepares for International Space Station operations.

PubMed

Messerschmid, E; Haignere, J P; Damian, K; Damann, V

2004-04-01

The European Space Agency (ESA) contribution to the International Space Station (ISS) goes much beyond the delivery of hardware like the Columbus Laboratory, its payloads and the Automated Transfer Vehicles. ESA Astronauts will be members of the ISS crew. ESA, according to its commitments as ISS international partner, will be responsible to provide training on its elements and payloads to all ISS crewmembers and medical support for ESA astronauts. The European Astronaut Centre (EAC) in Cologne has developed over more than a decade into the centre of expertise for manned space activities within ESA by contributing to a number of important co-operative spaceflight missions. This role will be significantly extended for ISS manned operations. Apart from its support to ESA astronauts and their onboard operations, EAC will have a key role in training all ISS astronauts on ESA elements and payloads. The medical support of ISS crew, in particular of ESA astronauts has already started. This paper provides an overview on status and further plans in building up this homebase function for ESA astronauts and on the preparation towards Training Readiness for ISS crew training at EAC, Cologne. Copyright 2001 by the European Space Agency. Published by the American Institute of Aeronautics and Astronautics, Inc., with permission. Released to IAF/IAA/AIAA to publish in all forms. c2003 Elsevier Ltd. All rights reserved.

Estimating injury severity using the Barell matrix

PubMed Central

Clark, D E; Ahmad, S

2006-01-01

Objective To determine whether the Barell matrix (Inj Prev 2002;8:91–6) could effectively categorize injuries by severity. Methods Injury diagnoses of cases in the 2002 US Nationwide Inpatient Sample were classified according to the Barell matrix. For each cell of the matrix, the authors used ICDMAP‐90 to determine the predominant Abbreviated Injury Score (AIS) and body region, and calculated the weighted proportion surviving (bPScell) among patients with any diagnosis in that cell. These findings were used to estimate maximum AIS (bAISmax), ISS (bISS), and the minimum or product of bPScell (bPSmin, bPSprod) for injured patients in the 1996–2000 US National Hospital Discharge Surveys. Case survival was determined for different scores, and outcome models using age, sex, comorbidity, mechanism, and bISS or bPSmin were compared to models using ISS calculated from ICDMAP‐90 (mISS) or using ICISS. Results Case survival decreased with increasing bAISmax or bISS; survival was closely approximated by bPSmin, and also increased monotonically with bPSprod. Outcome models using bISS or bPSmin were similar to those using mISS or ICISS. An Abbreviated Barell Categorization, with only four groups, was also effective. Conclusion Barell matrix categorization of administrative data allows severity scoring similar to that obtainable with ICDMAP‐90 or ICISS. PMID:16595426

Biomechanical Analysis of T2 Exercise

NASA Technical Reports Server (NTRS)

DeWitt, John K.; Ploutz-Snyder, Lori; Everett, Meghan; Newby, Nathaniel; Scott-Pandorf, Melissa; Guilliams, Mark E.

2010-01-01

Crewmembers regularly perform treadmill exercise on the ISS. With the implementation of T2 on ISS, there is now the capacity to obtain ground reaction force (GRF) data GRF data combined with video motion data allows biomechanical analyses to occur that generate joint torque estimates from exercise conditions. Knowledge of how speed and load influence joint torque will provide quantitative information on which exercise prescriptions can be based. The objective is to determine the joint kinematics, ground reaction forces, and joint kinetics associated with treadmill exercise on the ISS. This study will: 1) Determine if specific exercise speed and harness load combinations are superior to others in exercise benefit; and 2) Aid in the design of exercise prescriptions that will be most beneficial in maintaining crewmember health.

Relaxing USOS Solar Array Constraints for Russian Vehicle Undocking

NASA Technical Reports Server (NTRS)

Menkin, Evgeny; Schrock, Mariusz; Schrock, Rita; Zaczek, Mariusz; Gomez, Susan; Lee, Roscoe; Bennet, George

2011-01-01

With the retirement of Space Shuttle cargo delivery capability and the ten year life extension of the International Space Station (ISS) more emphasis is being put on preservation of the service life of ISS critical components. Current restrictions on the United States Orbital Segment (USOS) Solar Array (SA) positioning during Russian Vehicle (RV) departure from ISS nadir and zenith ports cause SA to be positioned in the plume field of Service Module thrusters and lead to degradation of SAs as well as potential damage to Sun tracking Beta Gimbal Assemblies (BGA). These restrictions are imposed because of the single fault tolerant RV Motion Control System (MCS), which does not meet ISS Safety requirements for catastrophic hazards and dictates 16 degree Solar Array Rotary Joint position, which ensures that ISS and RV relative motion post separation, does lead to collision. The purpose of this paper is to describe a methodology and the analysis that was performed to determine relative motion trajectories of the ISS and separating RV for nominal and contingency cases. Analysis was performed in three phases that included ISS free drift prior to Visiting Vehicle separation, ISS and Visiting Vehicle relative motion analysis and clearance analysis. First, the ISS free drift analysis determined the worst case attitude and attitude rate excursions prior to RV separation based on a series of different configurations and mass properties. Next, the relative motion analysis calculated the separation trajectories while varying the initial conditions, such as docking mechanism performance, Visiting Vehicle MCS failure, departure port location, ISS attitude and attitude rates at the time of separation, etc. The analysis employed both orbital mechanics and rigid body rotation calculations while accounting for various atmospheric conditions and gravity gradient effects. The resulting relative motion trajectories were then used to determine the worst case separation envelopes during the clearance analysis. Analytical models were developed individually for each stage and the results were used to build initial conditions for the following stages. In addition to the analysis approach, this paper also discusses the analysis results, showing worst case relative motion envelopes, the recommendations for ISS appendage positioning and the suggested approach for future analyses.

Estimation of plasma fibrinogen levels based on hemoglobin, base excess and Injury Severity Score upon emergency room admission

PubMed Central

2013-01-01

Introduction Fibrinogen plays a key role in hemostasis and is the first coagulation factor to reach critical levels in massively bleeding trauma patients. Consequently, rapid estimation of plasma fibrinogen (FIB) is essential upon emergency room (ER) admission, but is not part of routine coagulation monitoring in many centers. We investigated the predictive ability of the laboratory parameters hemoglobin (Hb) and base excess (BE) upon admission, as well as the Injury Severity Score (ISS), to estimate FIB in major trauma patients. Methods In this retrospective study, major trauma patients (ISS ≥16) with documented FIB analysis upon ER admission were eligible for inclusion. FIB was correlated with Hb, BE and ISS, alone and in combination, using regression analysis. Results A total of 675 patients were enrolled (median ISS 27). FIB upon admission correlated strongly with Hb, BE and ISS. Multiple regression analysis showed that Hb and BE together predicted FIB (adjusted R2 = 0.46; loge(FIB) = 3.567 + 0.223.Hb - 0.007.Hb2 + 0.044.BE), and predictive strength increased when ISS was included (adjusted R2 = 0.51; loge(FIB) = 4.188 + 0.243.Hb - 0.008.Hb2 + 0.036.BE - 0.031.ISS + 0.0003.ISS2). Of all major trauma patients admitted with Hb <12 g/dL, 74% had low (<200 mg/dL) FIB and 54% had critical (<150 mg/dL) FIB. Of patients admitted with Hb <10 g/dL, 89% had low FIB and 73% had critical FIB. These values increased to 93% and 89%, respectively, among patients with an admission Hb <8 g/dL. Sixty-six percent of patients with only a weakly negative BE (<−2 mmol/L) showed low FIB. Of patients with BE <−6 mmol/L upon admission, 81% had low FIB and 63% had critical FIB. The corresponding values for BE <−10 mmol/L were 89% and 78%, respectively. Conclusions Upon ER admission, FIB of major trauma patients shows strong correlation with rapidly obtainable, routine laboratory parameters such as Hb and BE. These two parameters might provide an insightful and rapid tool to identify major trauma patients at risk of acquired hypofibrinogenemia. Early calculation of ISS could further increase the ability to predict FIB in these patients. We propose that FIB can be estimated during the initial phase of trauma care based on bedside tests. PMID:23849249

Whitson holds the ADVASC Soybean plant growth experiment in the U.S. Laboratory

NASA Image and Video Library

2002-07-10

ISS005-E-07209 (10 July 2002) --- Astronaut Peggy A. Whitson, Expedition Five NASA ISS science officer, holds the Advanced Astroculture soybean plant growth experiment in the Destiny laboratory on the International Space Station (ISS).

ISS NASA Social

NASA Image and Video Library

2013-02-20

A NASA Social participant asks a question to the astronauts onboard the International Space Station in a live downlink from the ISS at a NASA Social exploring science on the ISS at NASA Headquarters, Wednesday, Feb. 20, 2013 in Washington. Photo Credit: (NASA/Carla Cioffi)

Flight Engineer Donald R. Pettit is troubleshooting the MSG in the U.S. Laboratory

NASA Image and Video Library

2003-02-27

ISS006-E-34567 (27 February 2003) --- Astronaut Donald R. Pettit, Expedition Six NASA ISS science officer, works on the Microgravity Science Glovebox (MSG) in the Destiny laboratory on the International Space Station (ISS).

Whitson working on the MSG in the U.S. Laboratory during Expedition Five on the ISS

NASA Image and Video Library

2002-09-11

ISS005-E-13706 (11 September 2002) --- Astronaut Peggy A. Whitson, Expedition Five flight engineer, works with the Microgravity Science Glovebox (MSG) in the Destiny laboratory on the International Space Station (ISS).

Whitson working on the MSG in the U.S. Laboratory during Expedition Five on the ISS

NASA Image and Video Library

2002-09-11

ISS005-E-13704 (11 September 2002) --- Astronaut Peggy A. Whitson, Expedition Five flight engineer, works with the Microgravity Science Glovebox (MSG) in the Destiny laboratory on the International Space Station (ISS).

Lu plays music with a keyboard in the Destiny module

NASA Image and Video Library

2003-10-26

ISS007-E-18033 (26 October 2003) --- Astronaut Edward T. Lu, Expedition 7 NASA ISS science officer and flight engineer, plays a musical keyboard during off-shift time in the Destiny laboratory on the International Space Station (ISS).

Assessment of demographic and pathoanatomic risk factors in recurrent patellofemoral instability.

PubMed

Hiemstra, Laurie Anne; Kerslake, Sarah; Lafave, Mark

2017-12-01

The WARPS/STAID classification employs clinical assessment of presenting features and anatomic characteristics to identify two distinct subsets of patients within the patellofemoral instability population. The purpose of this study was to further define the specific demographics and the prevalence of risky pathoanatomies in patients classified as either WARPS or STAID presenting with recurrent patellofemoral instability. A secondary purpose was to further validate the WARPS/STAID classification with the Banff Patella Instability Instrument (BPII), the Marx activity scale and the Patellar Instability Severity Score (ISS). A convenience sample of 50 patients with recurrent patellofemoral instability, including 25 WARPS and 25 STAID subtype patients, were assessed. Clinical data were collected including assessment of demographic risk factors (sex, BMI, bilaterality of symptoms, affected limb side and age at first dislocation) and pathoanatomic risk factors (TT-TG distance, patella height, patellar tilt, grade of trochlear dysplasia, Beighton score and rotational abnormalities of the tibia or femur). Patients completed the BPII and the Marx activity scale. The ISS was calculated from the clinical assessment data. Patients were stratified into the WARPS or STAID subtypes for comparative analysis. An independent t test was used to compare demographics, the pathoanatomic risk factors and subjective measures between the groups. Convergent validity was tested with a Pearson r correlation coefficient between the WARPS/STAID and ISS scores. Demographic risk factors statistically associated with a WARPS subtype included female sex, age at first dislocation and bilaterality. Pathoanatomic risk factors statistically associated with a WARPS subtype included trochlear dysplasia, TT-TG distance, generalized ligamentous laxity, patellar tilt and rotational abnormalities. The independent t test revealed a significant difference between the ISS scores: WARPS subtype (M = 4.4, SD = 1.1) and STAID subtype (M = 2.5, SD = 1.5); t(48) = 5.2, p < 0.001. The relationship between the WARPS/STAID and the ISS scores, measured using a Pearson r correlation coefficient, demonstrated a strong relationship: r = -0.61, n = 50, p < 0.001. This study has demonstrated statistically significant evidence that certain demographics and pathoanatomies are more prevalent in each of the WARPS and STAID patellofemoral instability subtypes. There was no difference in quality-of-life or activity level between the subtypes. The WARPS/STAID score demonstrated convergent validity to the ISS and divergent validity to the BPII score and the Marx activity scale. This study has further validated both the WARPS/STAID classification and the ISS of patients that present with recurrent patellofemoral instability. III.

Study of capability of microorganisms to develop on construction materials used in space objects

NASA Astrophysics Data System (ADS)

Rakova, N.; Svistunova, Y.; Novikova, N.

One of the most topical issues nowadays in the whole set of space research is the study of microbiological risks (medical, technical, technological). Experiments held onboard MIR station and International Space Station (ISS) clearly demonstrated capacity of microorganisms to contaminate the environment, equipment and belonging of habitual compartments of space objects. In this connection microorganisms-biodestructors play an important role. In their vital functioning they are capable of causing biological damage of different polymers, biocorrosion of metals which can lead to serious difficulties in performing long-term flights, namely the planned mission to Mars. Our purpose was to study capability of growth and reproduction of microorganisms on construction materials of various chemical composition as the first stage of biodestruction process. In our research we used "flight" strains of bacteria (Bacillus subtilus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Pseudomonas pumilus etc.) recovered from the ISS environment in several missions. For control we used "earth" bacteria species with typical properties. To model the environment of the ISS we took construction materials which are widely used in the interior and equipment of the ISS. The results we've obtained show that some microorganisms are capable of living and reproducing themselves on construction materials and their capability is more pronounced than that of the "earth" species. The best capability for growth and reproduction was characteristic of Bacillus subtilus.

Sexual satisfaction and quality of life in major depressive disorder before and after treatment with citalopram in the STAR*D study.

PubMed

Ishak, Waguih William; Christensen, Scott; Sayer, Gregory; Ha, Khanh; Li, Ning; Miller, Jamie; Nguyen, Jaidyn Mai; Cohen, Robert M

2013-03-01

Major depressive disorder (MDD) patients often experience impaired sexual satisfaction (ISS) and poor quality of life (QOL). Selective serotonin reuptake inhibitors (SSRIs), the first-line treatment for MDD, can cause sexual dysfunction, potentially worsening ISS and QOL. This study examined the impact of MDD and the SSRI citalopram on sexual satisfaction and QOL in level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial (July 2001-September 2006). A retrospective analysis was conducted of the change in sexual satisfaction, as measured by item 9 of the Quality of Life Enjoyment and Satisfaction Questionnaire, the primary outcome measure, in 2,280 patients with DSM-IV-TR-defined MDD who were treated with citalopram for 12 weeks. The Quick Inventory of Depressive Symptomatology-Self Report was used to evaluate the impact of depression ratings on impaired sexual satisfaction and on QOL. Impaired sexual satisfaction was present in 64.3% of MDD patients at pretreatment, but that percentage declined to 47.1% at posttreatment with citalopram (P < .0001). Those who achieved remission had less ISS and better QOL. The prevalence of ISS in remitters was 21.2% versus 61.3% in nonremitters (P < 10(-8)). The mean ± standard deviation score for remitters increased from 2.32 ± 1.16 to 3.44 ± 1.23 (P < 10(-8); Cohen d = 0.81 [large effect size]), whereas in nonremitters it increased only from 1.99 ± 1.08 to 2.19 ± 1.19 (P < 10(-8); Cohen d = 0.16). The difference between remitters and nonremitters was highly significant (P < 10(-8)). Regression analyses at pretreatment and posttreatment demonstrated significant associations between depressive symptoms and ISS (P < .0001) and between ISS and lower QOL (P < .0001) as well as an association between citalopram and increased probability of ISS and a poorer QOL in patients who continue to have moderate-to-severe depression. A majority of MDD patients have impaired sexual satisfaction, a symptom associated with poor QOL. Despite the sexual side effects of the SSR citalopram, treating depression to full remission was associated with improvements in sexual satisfaction and QOL. ClinicalTrials.gov identifier: NCT00021528. © Copyright 2013 Physicians Postgraduate Press, Inc.

Early Communication System (ECOMM) for ISS

NASA Technical Reports Server (NTRS)

Gaylor, Kent; Tu, Kwei

1999-01-01

The International Space Station (ISS) Early Communications System (ECOMM) was a Johnson Space Center (JSC) Avionic Systems Division (ASD) in-house developed communication system to provide early communications between the ISS and the Mission Control Center-Houston (MCC-H). This system allows for low rate commands (link rate of 6 kbps) to be transmitted through the Tracking and Data Relay Satellite System (TDRSS) from MCC-H to the ISS using TDRSS's S-band Single Access Forward (SSA/) link service. This system also allows for low rate telemetry (link rate of 20.48 kbps) to be transmitted from ISS to MCC-H through the TDRSS using TDRSS's S-band Single Access Return (SSAR) link service. In addition this system supports a JSC developed Onboard Communications Adapter (OCA) that allows for a two-way data exchange of 128 kbps between MCC-H and the ISS through TDRSS. This OCA data can be digital video/audio (two-way videoconference), and/or file transfers, and/or "white board". The key components of the system, the data formats used by the system to insure compatibility with the future ISS S-Band System, as well as how other vehicles may be able to use this system for their needs are discussed in this paper.

Using the ISS as a testbed to prepare for the next generation of space-based telescopes

NASA Astrophysics Data System (ADS)

Postman, Marc; Sparks, William B.; Liu, Fengchuan; Ess, Kim; Green, Joseph; Carpenter, Kenneth G.; Thronson, Harley; Goullioud, Renaud

2012-09-01

The infrastructure available on the ISS provides a unique opportunity to develop the technologies necessary to assemble large space telescopes. Assembling telescopes in space is a game-changing approach to space astronomy. Using the ISS as a testbed enables a concentration of resources on reducing the technical risks associated with integrating the technologies, such as laser metrology and wavefront sensing and control (WFS&C), with the robotic assembly of major components including very light-weight primary and secondary mirrors and the alignment of the optical elements to a diffraction-limited optical system in space. The capability to assemble the optical system and remove and replace components via the existing ISS robotic systems such as the Special Purpose Dexterous Manipulator (SPDM), or by the ISS Flight Crew, allows for future experimentation as well as repair if necessary. In 2015, first light will be obtained by the Optical Testbed and Integration on ISS eXperiment (OpTIIX), a small 1.5-meter optical telescope assembled on the ISS. The primary objectives of OpTIIX include demonstrating telescope assembly technologies and end-to-end optical system technologies that will advance future large optical telescopes.

The First Decade of ISS Exercise: Lessons Learned on Expeditions 1-25.

PubMed

Hayes, Judith

2015-12-01

Long-duration spaceflight results in musculoskeletal, cardiorespiratory, and sensorimotor deconditioning. Historically, exercise has been used as a countermeasure to mitigate these deleterious effects that occur as a consequence of microgravity exposures. The International Space Station (ISS) exercise community describes their approaches, biomedical surveillance, and lessons learned in the development of exercise countermeasure modalities and prescriptions for maintaining health and performance among station crews. This report is focused on the first 10 yr of ISS defined as Expeditions 1-25 and includes only crewmembers with missions > 30 d on ISS for all 5 partner agencies (United States, Russia, Europe, Japan, and Canada). All 72 cosmonauts and astronauts participated in the ISS exercise countermeasures program. This Supplement presents a series of papers that provide an overview of the first decade of ISS exercise from a multidisciplinary, multinational perspective to evaluate the initial countermeasure program and record its operational limitations and challenges. In addition, we provide results from standardized medical evaluations before, during, and after each mission. Information presented in this context is intended to describe baseline conditions of the ISS exercise program. This paper offers an introduction to the subsequent series of manuscripts.

Human engineering and habitability: the critical challenges for the International Space Station.

PubMed

Novak, J B

2000-09-01

As the duration of spaceflight increases, the impact of habitability on mission success becomes significant. Habitability is based on the qualities and capabilities of an environment that enable people to work and live. Poor habitability can impact productivity, safety, well-being, and performance. The International Space Station (ISS) Operational Habitability Project has been established to address the increased role of habitability for ISS. The primary objective of the project is to establish a pool of data from which opinions and decisions for judging and improving habitability on ISS will be generated. The main activities of the project are to: 1) collect and interpret data related to habitability on ISS; 2) identify Operational Habitability Lessons Learned; and 3) provide data summaries, judgments, and recommendations for the improvement of habitability. As an example, the ISS Operational Habitability Project has provided significant inputs to a current ISS issue regarding stowage. In this situation, a lack of prioritization on habitability resulted in a less than ideal situation. Operational Habitability data from previous missions was identified and summarized to provide inputs to assist in working the issues toward a resolution that supports habitability on ISS.

Implementation of a Water Flow Control System into the ISS'S Planned Fluids & Combustion Facility

NASA Technical Reports Server (NTRS)

Edwards, Daryl A.

2003-01-01

The Fluids and Combustion Facility (FCF) will become an ISS facility capable of performing basic combustion and fluids research. The facility consists of two independent payload racks specifically configured to support multiple experiments over the life of the ISS. Both racks will depend upon the ISS's Moderate Temperature Loop (MTL) for removing waste heat generated by the avionics and experiments operating within the racks. By using the MTL, constraints are imposed by the ISS vehicle on how the coolant resource is used. On the other hand, the FCF depends upon effective thermal control for maximizing life of the hardware and for supplying proper boundary conditions for the experiments. In the implementation of a design solution, significant factors in the selection of the hardware included ability to measure and control relatively low flow rates, ability to throttle flow within the time constraints of the ISS MTL, conserve energy usage, observe low mass and small volume requirements. An additional factor in the final design solution selection was considering how the system would respond to a loss of power event. This paper describes the method selected to satisfy the FCF design requirements while maintaining the constraints applied by the ISS vehicle.

Sustaining a Mature Risk Management Process: Ensuring the International Space Station for a Vibrant Future

NASA Technical Reports Server (NTRS)

Raftery, Michael; Carter-Journet, Katrina

2013-01-01

The International Space Station (ISS) risk management methodology is an example of a mature and sustainable process. Risk management is a systematic approach used to proactively identify, analyze, plan, track, control, communicate, and document risks to help management make risk-informed decisions that increase the likelihood of achieving program objectives. The ISS has been operating in space for over 14 years and permanently crewed for over 12 years. It is the longest surviving habitable vehicle in low Earth orbit history. Without a mature and proven risk management plan, it would be increasingly difficult to achieve mission success throughout the life of the ISS Program. A successful risk management process must be able to adapt to a dynamic program. As ISS program-level decision processes have evolved, so too has the ISS risk management process continued to innovate, improve, and adapt. Constant adaptation of risk management tools and an ever-improving process is essential to the continued success of the ISS Program. Above all, sustained support from program management is vital to risk management continued effectiveness. Risk management is valued and stressed as an important process by the ISS Program.

Occlusal Characteristics of Individuals with Growth Hormone Deficiency, Idiopathic Short Stature, and Russell-Silver Syndrome.

PubMed

Hodge, Natalia; Evans, Carla A; Simmons, Kirt E; Fadavi, Shahrbanoo; Viana, Grace

2015-01-01

The purpose of this study was to assess the occlusal characteristics of individuals with growth hormone deficiency (GHD), idiopathic short stature (ISS), and Russell-Silver syndrome (RSS), and compare them to the means of a normal population. Data about the stage of dentition, diastema, maxillary transverse deficiency, overjet, overbite, molar classification, and maxillary and mandibular crowding were obtained from orthodontic screening notes and standardized clinical exams of children with growth disorders seen at screening events. The prevalence of these occlusal characteristics was calculated and compared to the pooled mean of a normal population as determined by the National Health and Nutrition Examination Survey studies. Twenty RSS subjects and 16 subjects with GHD or ISS were studied. The RSS cohort presented statistically significant greater mean overbite as well as mandibular and maxillary crowding compared to the general population. Descriptive statistics were performed for the GHD and ISS group. Occlusal abnormalities are prevalent in children with growth disorders.

iss049e012018

NASA Image and Video Library

2016-09-27

ISS049e012018 (09/27/2016) --- Expedition 49 crewmember Kate Rubins of NASA works with the airlock inside of Kibo, the Japanese Experiment Module. Rubins was installing the Robotics External Leak Locator (RELL), a technology demonstration designed to locate external ISS ammonia (NH3) leaks.

Fincke holds an ammonia test strip while working in the U.S. Laboratory during EXP 9 / EXP 8

NASA Image and Video Library

2004-04-27

ISS008-E-22350 (27 April 2004) --- Astronaut Edward M. (Mike) Fincke, Expedition 9 NASA ISS science officer and flight engineer, works in the Destiny laboratory of the International Space Station (ISS).

Chiao watches a water bubble float in the SM taken during Expedition 10

NASA Image and Video Library

2005-01-15

ISS010-E-13569 (15 January 2005) --- Astronaut Leroy Chiao, Expedition 10 commander and NASA ISS science officer, watches a water bubble float between him and the camera, showing his image refracted, on the International Space Station (ISS).

International Space Station (ISS)

NASA Image and Video Library

1994-07-20

An artist's conception of what the final configuration of the International Space Station (ISS) will look like when it is fully built and deployed. The ISS is a multidisciplinary laboratory, technology test bed, and observatory that will provide an unprecedented undertaking in scientific, technological, and international experimentation.

Flight Engineer Donald R. Pettit exercises on the TVIS in the SM during Expedition Six

NASA Image and Video Library

2003-03-20

ISS006-E-45265 (20 March 2003) --- Astronaut Donald R. Pettit, Expedition 6 NASA ISS science officer, exercises on the Treadmill Vibration Isolation System (TVIS) in the Zvezda Service Module on the International Space Station (ISS).

Code of conduct for the International Space Station Crew. National Aeronautics and Space Administration (NASA). Interim final rule.

PubMed

2000-12-21

NASA is issuing new regulations entitled "International Space Station Crew," to implement certain provisions of the International Space Station (ISS) Intergovernmental Agreement (IGA) regarding ISS crewmembers' observance of an ISS Code of Conduct.

Duque works at the MSG for PromISS 2 in the Lab during Expedition Seven / 8 OPS

NASA Image and Video Library

2003-10-27

ISS008-E-05009 (27 October 2003) --- European Space Agency (ESA) astronaut Pedro Duque of Spain works with the Microgravity Science Glovebox (MSG) in the Destiny laboratory on the International Space Station (ISS).

ISS 7A.1 Flight Control Team Photo in BFCR

NASA Image and Video Library

2001-08-16

JSC2001-02227 (16 August 2001) --- The members of the STS-105/ISS 7A.1 Planning team pose for a group portrait in the International Space Station (ISS) flight control room (BFCR) in Houston’s Mission Control Center (MCC).

iss003e8406

NASA Image and Video Library

2001-12-12

ISS003-E-8406 (12 December 2001) --- Astronauts Frank L. Culbertson, Jr. (left), Expedition Three mission commander, and Daniel W. Bursch, Expedition Four flight engineer, work in the Zvezda Service Module on the International Space Station (ISS). The image was taken with a digital still camera.

AN-Type Fittings in the International Space System (ISS) Node 2 Ammonia System Technical Assessment Report

NASA Technical Reports Server (NTRS)

Cragg, Clinton H.; Dibbern, Andreas W.; Beil, Robert J.; Terrone, Mark; Rotter, Henry A.; Ernest, Steve; Frankenfield, Bruce; Solano, Paul

2009-01-01

Based on an anonymous request, an NESC Assessment Team was formed to investigate potential leakage problems from the ISS Program's Node 2 Anhydrous Ammonia System AN fittings. The Team's charter was to provide the ISS Program with a path to follow, which could include testing, to ensure the ISS Program felt confident that the AN fittings' leakage would not exceed specified limits in orbit. The findings from that assessment are contained in this document.

Distant view of the ISS as OV-104 makes its initial approach during STS-106

NASA Image and Video Library

2000-09-09

S106-E-5056 (10 September 2000) --- The International Space Station (ISS) is now in the view of the crew aboard the Space Shuttle Atlantis as evidenced in this electronic image. The last time astronauts saw the ISS, it was not sporting the recently-arriving Progress, which appears at the top in this perspective. Also, next to the Progress, appears the Zvezda service module, which had been delivered by a Proton rocket since the most recent human visit to ISS.

KSC ISS Logistics Support

NASA Technical Reports Server (NTRS)

Tellado, Joseph

2014-01-01

The presentation contains a status of KSC ISS Logistics Operations. It basically presents current top level ISS Logistics tasks being conducted at KSC, current International Partner activities, hardware processing flow focussing on late Stow operations, list of KSC Logistics POC's, and a backup list of Logistics launch site services. This presentation is being given at the annual International Space Station (ISS) Multi-lateral Logistics Maintenance Control Panel meeting to be held in Turin, Italy during the week of May 13-16. The presentatiuon content doesn't contain any potential lessons learned.

International Space Station (ISS)

NASA Image and Video Library

2001-08-12

In this photograph, Astronaut Susan Helms, Expedition Two flight engineer, is positioned near a large amount of water temporarily stored in the Unity Node aboard the International Space Station (ISS). Astronaut Helms accompanied the STS-105 crew back to Earth after having spent five months with two crewmates aboard the ISS. The 11th ISS assembly flight, the Space Shuttle Orbiter Discovery STS-105 mission was launched on August 10, 2001, and landed on August 22, 2001 at the Kennedy Space Center after the completion of the successful 12-day mission.

New Method for Updating Mean Time Between Failure for ISS Orbital Replaceable Units Consultation Report

NASA Technical Reports Server (NTRS)

Parsons, Vickie S.

2009-01-01

A request to conduct a peer review of the International Space Station (ISS) proposal to use Bayesian methodology for updating Mean Time Between Failure (MTBF) for ISS Orbital Replaceable Units (ORU) was submitted to the NASA Engineering and Safety Center (NESC) on September 20, 2005. The results were requested by October 20, 2005 in order to be available during the process of reworking the current ISS flight manifest. The results are included in this report.

ISS Plasma Environment: Status of CCMC Products for ISS Mission Ops

NASA Technical Reports Server (NTRS)

Minow, Joseph

2010-01-01

ISS Program currently using FPMU Ne, Te in-situ measurements to support operations and anomaly investigations. Working to acquire alternative data sources if FPMU is not available. Work is progressing on CCMC tools for low Earth orbit ionosphere characterization. Validation against FPMU data required before model output can be used for ISS operational support. MSFC plans to continue comparing CTIP output during FPMU campaigns. Results to date have been useful in identifying ionospheric origins of high latitude charging environments.

PHOTO DATE: 04-23-15.LOCATION: Bldg. 9NW - ISS Airlock Mockup .SUBJECT: Expedition 48/49 (Soyuz 47) crew members Kate Rubins and Takuya Onishi with Soyuz 49 crew member Peggy Whitson during ISS EVA P/P 1 training with instructor Grant Slusser.PHOTOGRAPHER: BILL STAFFORD

NASA Image and Video Library

2015-04-23

PHOTO DATE: 04-23-15 LOCATION: Bldg. 9NW - ISS Airlock Mockup SUBJECT: Expedition 48/49 (Soyuz 47) crew members Kate Rubins and Takuya Onishi with Soyuz 49 crew member Peggy Whitson during ISS EVA P/P 1 training with instructor Grant Slusser PHOTOGRAPHER: BILL STAFFORD