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Sample records for sector mal drenado

  1. Constitutive Mutations of the Saccharomyces Cerevisiae Mal-Activator Genes Mal23, Mal43, Mal63, and Mal64

    PubMed Central

    Gibson, A. W.; Wojciechowicz, L. A.; Danzi, S. E.; Zhang, B.; Kim, J. H.; Hu, Z.; Michels, C. A.

    1997-01-01

    We report the sequence of several MAL-activator genes, including inducible, constitutive, and noninducible alleles of MAL23, MAL43, MAL63, and mal64. Constitutive alleles of MAL23 and MAL43 vary considerably from inducible alleles in their C-terminal domain, with many of the alterations clustered and common to both alleles. The 27 alterations from residues 238-461 of Mal43-C protein are sufficient for constitutivity, but the minimal number of alterations needed for the constitutive phenotype could not be determined. The sequence of mal64, a nonfunctional homologue of MAL63, revealed that Mal64p is 85% identical to Mal63p. Two mutations that activate mal64 and cause constitutivity are nonsense mutations resulting in truncated proteins of 306 and 282 residues. We conclude that the C-terminal region of the MAL-activator, from residues 283-470, contains a maltose-responsive negative regulatory domain, and that extensive mutation or deletion of the entire region causes loss of the negative regulatory function. Additionally, certain sequence elements in the region appear to be necessary for efficient induction of the full-length Mal63 activator protein. These studies highlight the role of ectopic recombination as an important mechanism of mutagenesis of the telomere-associated family of MAL loci. PMID:9258674

  2. Mal de Meleda.

    PubMed

    Urbina, F; Cristóbal, M C; Sandoval, R

    1995-10-01

    A case of mal de Meleda originating in Chile is reported. The patient had no history of consanguinity and cases could not be detected in four generations of the patient's family. The palmoplantar keratoderma was progrediens and transgrediens, with distant hyperkeratotic plaques of the knees and elbows. The nails, hair, and teeth were normal.

  3. Maltose-Dependent Transcriptional Regulation of the mal Regulon by MalR in Streptococcus pneumoniae.

    PubMed

    Afzal, Muhammad; Shafeeq, Sulman; Manzoor, Irfan; Kuipers, Oscar P

    2015-01-01

    The maltose regulon (mal regulon) has previously been shown to consist of the mal gene cluster (malMP, malXCD and malAR operons) in Streptococcus pneumoniae. In this study, we have further elucidated the complete mal regulon in S. pneumoniae D39 using microarray analyses and β-galactosidase assays. In addition to the mal gene cluster, the complete mal regulon of S. pneumoniae D39 consists of a pullulanase (PulA), a glucosidase (DexB), a glucokinase (RokB), a PTS component (PtsG) and an amylase (AmyA2). Our microarray studies and β-galactosidase assays further showed that the LacI-family transcriptional regulator MalR represses the expression of the mal regulon in the absence of maltose. Furthermore, the role of the pleiotropic transcriptional regulator CcpA in the regulation of the mal regulon in the presence of maltose was explored. Our microarray analysis with a ΔccpA strain showed that CcpA only represses the expression of the malXCD operon and the pulA gene in the presence of maltose. Hence, we extend the mal regulon now consisting of pulA, dexB, rokB, ptsG and amyA2 in addition to malMP, malXCD and malAR operons.

  4. Mal del pinto in Mexico*

    PubMed Central

    Marquez, Francisco; Rein, Charles R.; Arias, Oswaldo

    1955-01-01

    This report deals with the geographical distribution, prevalence, epidemiology, etiology, serological, clinical, and histopathological features, and treatment of mal del pinto, or pinta, in Mexico. Repository penicillin preparations (PAM and Panbiotic) have been found highly effective in the treatment of this endemic, non-venereal treponematosis. ImagesFIG. 1FIG. 2FIG. 3FIG. 4FIG. 5FIG. 6FIG. 7FIG. 8 PMID:13260889

  5. Virus Characterization by FFF-MALS Assay

    NASA Astrophysics Data System (ADS)

    Razinkov, Vladimer

    2009-03-01

    Adequate biophysical characterization of influenza virions is important for vaccine development. The influenza virus vaccines are produced from the allantoic fluid of developing chicken embryos. The process of viral replication produces a heterogeneous mixture of infectious and non-infectious viral particles with varying states of aggregation. The study of the relative distribution and behavior of different subpopulations and their inter-correlation can assist in the development of a robust process for a live virus vaccine. This report describes a field flow fractionation and multiangle light scattering (FFF-MALS) method optimized for the analysis of size distribution and total particle counts. A method using a combination of asymmetric flow field-flow fractionation (AFFFF) and multiangle light scattering (MALS) techniques has been shown to improve the estimation of virus particle counts and the amount of aggregated virus in laboratory samples. The FFF-MALS method was compared with several other methods such as transmission electron microscopy (TEM), atomic force microscopy (AFM), size exclusion chromatography followed by MALS (SEC-MALS), quantitative reverse transcription polymerase chain reaction (RT Q-PCR), median tissue culture dose (TCID(50)), and the fluorescent focus assay (FFA). The correlation between the various methods for determining total particle counts, infectivity and size distribution is reported. The pros and cons of each of the analytical methods are discussed.

  6. Regulation of the malic enzyme gene malE by the transcriptional regulator MalR in Corynebacterium glutamicum.

    PubMed

    Krause, Jens P; Polen, Tino; Youn, Jung-Won; Emer, Denise; Eikmanns, Bernhard J; Wendisch, Volker F

    2012-06-15

    Corynebacterium glutamicum is a Gram-positive nonpathogenic bacterium that is used for the biotechnological production of amino acids. Here, we investigated the transcriptional control of the malE gene encoding malic enzyme (MalE) in C. glutamicum ATCC 13032, which is known to involve the nitrogen regulator AmtR. Gel shift experiments using purified regulators RamA and RamB revealed binding of these regulators to the malE promoter. In DNA-affinity purification experiments a hitherto uncharacterized transcriptional regulator belonging to the MarR family was found to bind to malE promoter DNA and was designated as MalR. C. glutamicum cells overexpressing malR showed reduced MalE activities in LB medium or in minimal media with acetate, glucose, pyruvate or citrate. Deletion of malR positively affected MalE activities during growth in LB medium and minimal media with pyruvate, glucose or the TCA cycle dicarboxylates l-malate, succinate and fumarate. Transcriptional fusion analysis revealed elevated malE promoter activity in the malR deletion mutant during growth in pyruvate minimal medium suggesting that MalR acts as a repressor of malE. Purified MalR bound malE promoter DNA in gel shift experiments. Two MalR binding sites were identified in the malE promoter by mutational analysis. Thus, MalR contributes to the complex transcriptional control of malE which also involves RamA, RamB and AmtR.

  7. Mal de Debarquement (Sickness of Disembarkment)

    MedlinePlus

    ... that will counter the different, rhythmical shipboard movements. Adaptation to such movement is sometimes referred to as ... Shupak A. “Clinical features of mal de débarquement: adaptation and habituation to sea conditions.” Journal of Vestibular ...

  8. The Constitutive, Glucose-Repression-Insensitive Mutation of the Yeast MAL4 Locus Is an Alteration of the MAL43 Gene

    PubMed Central

    Charron, Maureen J.; Michels, Corinne A.

    1987-01-01

    Mutations resulting in constitutive production of maltase have been identified at each of the five MAL loci of Saccharomyces yeasts. Here we examine a dominant constitutive, glucose-repression-insensitive allele of the MAL4 locus (MAL4-C). Our results demonstrate that MAL4-C is an alteration in the MAL43 gene, which encodes the positive regulator of the MAL structural genes, and that its product is trans-acting. The MAL43 gene from the MAL4-C strain was cloned and integrated into a series of nonfermenting strains lacking a functional regulatory gene but carrying copies of the maltose permease and maltase structural genes. Expression of the maltase structural gene was both constitutive and insensitive to glucose repression in these transformants. The MAL4-C allele also results in constitutive expression of the unlinked MAL12 gene (encoding maltase) in this strain. In addition, the cloned MAL43 gene was shown to be dominant to the wild-type MAL63 gene. We also show that most of the glucose repression insensitivity of strains carrying the MAL4-C allele results from alteration of MAL43. PMID:3036644

  9. Effects of MAL61 and MAL62 overexpression on maltose fermentation of baker's yeast in lean dough.

    PubMed

    Zhang, Cui-Ying; Lin, Xue; Song, Hai-Yan; Xiao, Dong-Guang

    2015-08-01

    The predominant fermentable sugar in lean dough is maltose. To improve the leavening ability of baker's yeast in lean dough, maltose metabolism should be improved. Maltase (alpha-glucosidase, encoded by MAL62) and maltose permease (encoded by MAL61) are the major factors involved in maltose metabolism. The major rate-limiting factor in maltose metabolism and leavening ability of baker's yeast remains unclear. In this work, MAL61 and/or MAL62 overexpression strains were constructed to investigate the decisive factor for maltose metabolism of industrial baker's yeast in lean dough. Our results show that elevated maltose permease activity by MAL61 overexpression yielded less improvement in maltose fermentation compared to elevated maltase activity by MAL62 overexpression. Significant increase in maltase activity by MAL62 overexpression could result in a 44% increase in leavening ability of industrial baker's yeast in lean dough and a 39% increase in maltose metabolism in a medium containing glucose and maltose. Thus, maltase was the rate-limiting factor in maltose fermentation of industrial baker's yeast in lean dough. This study lays a foundation for breeding of industrial baker's yeast for quick dough leavening.

  10. Characterization and expression analysis of a maltose-utilizing (MAL) cluster in Aspergillus oryzae.

    PubMed

    Hasegawa, Sachiko; Takizawa, Masahiro; Suyama, Haruhiko; Shintani, Takahiro; Gomi, Katsuya

    2010-01-01

    Starch and maltooligosaccharides such as maltose and maltotriose induce the production of amylolytic enzymes including alpha-amylase in Aspergillus oryzae. A transcriptional activator gene amyR, required for maltose induction of amylolytic enzymes, has been cloned and characterized. The amyR gene deletion mutant showed significantly poor growth on starch medium but normal growth on maltose medium. This indicated the existence of another maltose-utilizing system, whose expression might not be controlled by amyR. We have identified a gene cluster homologous to the MAL cluster of Saccharomyces cerevisiae in the A. oryzae genome. The cluster consists of a MAL61 homolog (designated malP), a MAL62 homolog (designated malT), and a MAL63 homolog (designated malR). Overexpression of malT in A. oryzae resulted in a significant increase in intracellular alpha-glucosidase activity, and that of malP allowed S. cerevisiaemal61Delta to grow on maltose. The expression of both malP and malT genes was highly up-regulated in the presence of maltose, but malR expressed constitutively irrespective of carbon sources. Disruption of malR resulted in the loss of malP and malT expression and thus in restricted growth on maltose medium. In addition, a malP disruptant showed a significantly reduced expression of malT and malR and exhibited a growth defect on maltose similar to the malR disruptant. These results suggest that the MAL cluster of A. oryzae is responsible for the assimilation of maltose in A. oryzae.

  11. Agriculture Sectors

    EPA Pesticide Factsheets

    The Agriculture sectors comprise establishments primarily engaged in growing crops, raising animals, and harvesting fish and other animals. Find information on compliance, enforcement and guidance on EPA laws and regulations on the NAICS 111 & 112 sectors.

  12. Microbiologic Methods Utilized in the MAL-ED Cohort Study

    PubMed Central

    Houpt, Eric; Gratz, Jean; Kosek, Margaret; Zaidi, Anita K. M.; Qureshi, Shahida; Kang, Gagandeep; Babji, Sudhir; Mason, Carl; Bodhidatta, Ladaporn; Samie, Amidou; Bessong, Pascal; Barrett, Leah; Lima, Aldo; Havt, Alexandre; Haque, Rashidul; Mondal, Dinesh; Taniuchi, Mami; Stroup, Suzanne; McGrath, Monica; Lang, Dennis

    2014-01-01

    A central hypothesis of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is that enteropathogens contribute to growth faltering. To examine this question, the MAL-ED network of investigators set out to achieve 3 goals: (1) develop harmonized protocols to test for a diverse range of enteropathogens, (2) provide quality-assured and comparable results from 8 global sites, and (3) achieve maximum laboratory throughput and minimum cost. This paper describes the rationale for the microbiologic assays chosen and methodologies used to accomplish the 3 goals. PMID:25305291

  13. Microbiologic methods utilized in the MAL-ED cohort study.

    PubMed

    Houpt, Eric; Gratz, Jean; Kosek, Margaret; Zaidi, Anita K M; Qureshi, Shahida; Kang, Gagandeep; Babji, Sudhir; Mason, Carl; Bodhidatta, Ladaporn; Samie, Amidou; Bessong, Pascal; Barrett, Leah; Lima, Aldo; Havt, Alexandre; Haque, Rashidul; Mondal, Dinesh; Taniuchi, Mami; Stroup, Suzanne; McGrath, Monica; Lang, Dennis

    2014-11-01

    A central hypothesis of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is that enteropathogens contribute to growth faltering. To examine this question, the MAL-ED network of investigators set out to achieve 3 goals: (1) develop harmonized protocols to test for a diverse range of enteropathogens, (2) provide quality-assured and comparable results from 8 global sites, and (3) achieve maximum laboratory throughput and minimum cost. This paper describes the rationale for the microbiologic assays chosen and methodologies used to accomplish the 3 goals.

  14. Investigation of the malE promoter and MalR, a positive regulator of the maltose regulon, for an improved expression system in Sulfolobus acidocaldarius.

    PubMed

    Wagner, Michaela; Wagner, Alexander; Ma, Xiaoqing; Kort, Julia Christin; Ghosh, Abhrajyoti; Rauch, Bernadette; Siebers, Bettina; Albers, Sonja-Verena

    2014-02-01

    In this study, the regulator MalR (Saci_1161) of the TrmB family from Sulfolobus acidocaldarius was identified and was shown to be involved in transcriptional control of the maltose regulon (Saci_1660 to Saci_1666), including the ABC transporter (malEFGK), α-amylase (amyA), and α-glycosidase (malA). The ΔmalR deletion mutant exhibited a significantly decreased growth rate on maltose and dextrin but not on sucrose. The expression of the genes organized in the maltose regulon was induced only in the presence of MalR and maltose in the growth medium, indicating that MalR, in contrast to its TrmB and TrmB-like homologues, is an activator of the maltose gene cluster. Electrophoretic mobility shift assays revealed that the binding of MalR to malE was independent of sugars. Here we report the identification of the archaeal maltose regulator protein MalR, which acts as an activator and controls the expression of genes involved in maltose transport and metabolic conversion in S. acidocaldarius, and its use for improvement of the S. acidocaldarius expression system under the control of an optimized maltose binding protein (malE) promoter by promoter mutagenesis.

  15. Evolution of mal ABC transporter operons in the Thermococcales and Thermotogales

    PubMed Central

    2008-01-01

    Background The mal genes that encode maltose transporters have undergone extensive lateral transfer among ancestors of the archaea Thermococcus litoralis and Pyrococcus furiosus. Bacterial hyperthermophiles of the order Thermotogales live among these archaea and so may have shared in these transfers. The genome sequence of Thermotoga maritima bears evidence of extensive acquisition of archaeal genes, so its ancestors clearly had the capacity to do so. We examined deep phylogenetic relationships among the mal genes of these hyperthermophiles and their close relatives to look for evidence of shared ancestry. Results We demonstrate that the two maltose ATP binding cassette (ABC) transporter operons now found in Tc. litoralis and P. furiosus (termed mal and mdx genes, respectively) are not closely related to one another. The Tc. litoralis and P. furiosus mal genes are most closely related to bacterial mal genes while their respective mdx genes are archaeal. The genes of the two mal operons in Tt. maritima are not related to genes in either of these archaeal operons. They are highly similar to one another and belong to a phylogenetic lineage that includes mal genes from the enteric bacteria. A unique domain of the enteric MalF membrane spanning proteins found also in these Thermotogales MalF homologs supports their relatively close relationship with these enteric proteins. Analyses of genome sequence data from other Thermotogales species, Fervidobacterium nodosum, Thermosipho melanesiensis, Thermotoga petrophila, Thermotoga lettingae, and Thermotoga neapolitana, revealed a third apparent mal operon, absent from the published genome sequence of Tt. maritima strain MSB8. This third operon, mal3, is more closely related to the Thermococcales' bacteria-derived mal genes than are mal1 and mal2. F. nodosum, Ts. melanesiensis, and Tt. lettingae have only one of the mal1-mal2 paralogs. The mal2 operon from an unknown species of Thermotoga appears to have been horizontally

  16. Characterization of mal recombination plasmids cloned in Streptococcus pneumoniae

    SciTech Connect

    Stassi, D.L.; Lopez, P.; Espinosa, M.; Lacks, S.A.

    1981-01-01

    The malM locus of Streptococcus pneumoniae was cloned into one of the two PstI sites of the multicopy S. pneumoniae plasmid pMV158. To eliminate chromosomal transformants in the simultaneous selection for tetracycline resistance (coded by pMV158) and maltose utilization, the host cells contained a chromosomal deletion of the mal gene cluster. Two clones were isolated; one with a 3.3 kb insert (pLS70) which behaved like wild type with respect to maltose utilization, and another with a 2.9 kb insert (pLS69) which behaved as though it contained a down promoter mutation. Preliminary mapping of these clones by restriction analysis placed the 0.4kb deletion on a HindIII fragment in the interior of the chromosomal insert. The recombinant plasmids were able to transform over 50% of a recipient population to Mal/sup +/. Enzyme measurements of the clones indicated an overproduction of amylomaltase, constituting up to 10% of the total cellular protein, and supported the theory that the deletion in the pLS69 is in the promoter region. Protein analysis by polyacrylamide gel electrophoresis confirmed that the amylomaltase polypeptide was produced in large amounts in induced cells containing the pLS70. Another polypeptide, possibly a fragment of the phosphorylase or X protein of the mal gene cluster, was also produced to a similar extent.

  17. Sensing actin dynamics: Structural basis for G-actin-sensitive nuclear import of MAL

    SciTech Connect

    Hirano, Hidemi; Matsuura, Yoshiyuki

    2011-10-22

    Highlights: {yields} MAL has a bipartite NLS that binds to Imp{alpha} in an extended conformation. {yields} Mutational analyses verified the functional significance of MAL-Imp{alpha} interactions. {yields} Induced folding and NLS-masking by G-actins inhibit nuclear import of MAL. -- Abstract: The coordination of cytoskeletal actin dynamics with gene expression reprogramming is emerging as a crucial mechanism to control diverse cellular processes, including cell migration, differentiation and neuronal circuit assembly. The actin-binding transcriptional coactivator MAL (also known as MRTF-A/MKL1/BSAC) senses G-actin concentration and transduces Rho GTPase signals to serum response factor (SRF). MAL rapidly shuttles between the cytoplasm and the nucleus in unstimulated cells but Rho-induced depletion of G-actin leads to MAL nuclear accumulation and activation of transcription of SRF:MAL-target genes. Although the molecular and structural basis of actin-regulated nucleocytoplasmic shuttling of MAL is not understood fully, it is proposed that nuclear import of MAL is mediated by importin {alpha}/{beta} heterodimer, and that G-actin competes with importin {alpha}/{beta} for the binding to MAL. Here we present structural, biochemical and cell biological evidence that MAL has a classical bipartite nuclear localization signal (NLS) in the N-terminal 'RPEL' domain containing Arg-Pro-X-X-X-Glu-Leu (RPEL) motifs. The NLS residues of MAL adopt an extended conformation and bind along the surface groove of importin-{alpha}, interacting with the major- and minor-NLS binding sites. We also present a crystal structure of wild-type MAL RPEL domain in complex with five G-actins. Comparison of the importin-{alpha}- and actin-complexes revealed that the binding of G-actins to MAL is associated with folding of NLS residues into a helical conformation that is inappropriate for importin-{alpha} recognition.

  18. [Petit mal status epilepticus with unusual clinical manifestations].

    PubMed

    Savitskaia, O N; Karlov, V A; Gleĭzer, M A; Pmotskaia, E E

    1980-01-01

    A unique observation of an epileptic female examined in detail in a neurological clinic is presented. The patient was later hospitalized 3 times for disturbances of consciousness and extrapyramid disorders characterized by acute onset. An encephalographic examination carried out during such a state showed an epileptic status of atypic absence. The development of the Parkinsonian syndrome is regarded as a proof of the role of the caudate nucleus in the genesis of the petit mal epileptic status.

  19. Integrating electrodermal biofeedback into pharmacologic treatment of grand mal seizures

    PubMed Central

    Scrimali, Tullio; Tomasello, Damiana; Sciuto, Massimo

    2015-01-01

    Electrodermal activity (EDA) and electrodermal biofeedback, when integrated with pharmacologic treatments, indicate promising methods for the treatment of grand mal seizures. They can be used to monitor patient arousal and help patients learn new strategies to better cope with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can improve their quality of life. This article describes the scientific background of electrodermal monitoring and electrodermal biofeedback for patients affected by grand mal seizures. In this study, we have reported a clinical case study. The patient was treated for 2 years with electrodermal biofeedback to augment pharmacologic treatments. The trial has been designed in accordance with “n = 1 case study research”. Our results have shown that our methods could achieve a significant reduction in grand mal seizures and sympathetic arousal when applied. The patient under consideration was also relaxed and exhibited greater competency to cope with stress. Additionally, the patient’s sense of mastery and self-efficacy was enhanced. PMID:26029078

  20. Metals Sector

    EPA Pesticide Factsheets

    Find environmental regulatory information about the metals sector (NAICS 331 & 332), including NESHAPs for metal coatings, effluent guidelines for metal products, combustion compliance assistance, and information about foundry sand recycling.

  1. Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization

    PubMed Central

    Phelps, Edward A.; Templeman, Kellie L.; Thulé, Peter M.; García, Andrés J.

    2013-01-01

    Biofunctionalized polyethylene glycol maleimide (PEG-MAL) hydrogels were engineered as a platform to deliver pancreatic islets to the small bowel mesentery and promote graft vascularization. VEGF, a potent stimulator of angiogenesis, was incorporated into the hydrogel to be released in an on-demand manner through enzymatic degradation. PEG-MAL hydrogel enabled extended in vivo release of VEGF. Isolated rat islets encapsulated in PEG-MAL hydrogels remained viable in culture and secreted insulin. Islets encapsulated in PEG-MAL matrix and transplanted to the small bowel mesentery of healthy rats grafted to the host tissue and revascularized by 4 weeks. Addition of VEGF release to the PEG-MAL matrix greatly augmented the vascularization response. These results establish PEG-MAL engineered matrices as a vascular-inductive cell delivery vehicle and warrant their further investigation as islet transplantation vehicles in diabetic animal models. PMID:25787738

  2. Sequential Action of MalE and Maltose Allows Coupling ATP Hydrolysis to Translocation in the MalFGK2 Transporter.

    PubMed

    Bao, Huan; Dalal, Kush; Cytrynbaum, Eric; Duong, Franck

    2015-10-16

    ATP-binding cassette (ABC) transporters have evolved an ATP-dependent alternating-access mechanism to transport substrates across membranes. Despite important progress, especially in their structural analysis, it is still unknown how the substrate stimulates ATP hydrolysis, the hallmark of ABC transporters. In this study, we measure the ATP turnover cycle of MalFGK2 in steady and pre-steady state conditions. We show that (i) the basal ATPase activity of MalFGK2 is very low because the cleavage of ATP is rate-limiting, (ii) the binding of open-state MalE to the transporter induces ATP cleavage but leaves release of Pi limiting, and (iii) the additional presence of maltose stimulates release of Pi, and therefore increases the overall ATP turnover cycle. We conclude that open-state MalE stabilizes MalFGK2 in the outward-facing conformation until maltose triggers return to the inward-facing state for substrate and Pi release. This concerted action explains why ATPase activity of MalFGK2 depends on maltose, and why MalE is essential for transport.

  3. Portable device for detection of petit mal epilepsy

    NASA Technical Reports Server (NTRS)

    Smith, R. G.; Houge, J. C.; Webster, J. G.

    1979-01-01

    A portable device that analyzes the electroencephalogram to determine if petit mal epilepsy waveforms are present is developed and tested. Clinicians should find it useful in diagnosing seizure activity of their patients. The micropower, battery-operated, portable device indicates a seizure has occurred if three criteria are satisfied: (1) frequencies of 2.5-7 Hz, (2) large-amplitude waves, and (3) minimum number of waves per second. Levels and counts are adjustable, thus insuring high reliability against noise artifacts and permitting each subject to be individually fitted. The device has shown promise in giving the patient a possible mechanism of seizure control or suppression.

  4. Clustering and Lateral Concentration of Raft Lipids by the MAL Protein

    PubMed Central

    Magal, Lee Goldstein; Yaffe, Yakey; Shepshelovich, Jeanne; Aranda, Juan Francisco; del Carmen de Marco, Maria; Gaus, Katharina; Alonso, Miguel Angel

    2009-01-01

    MAL, a compact hydrophobic, four-transmembrane-domain apical protein that copurifies with detergent-resistant membranes is obligatory for the machinery that sorts glycophosphatidylinositol (GPI)-anchored proteins and others to the apical membrane in epithelia. The mechanism of MAL function in lipid-raft–mediated apical sorting is unknown. We report that MAL clusters formed by two independent procedures—spontaneous clustering of MAL tagged with the tandem dimer DiHcRED (DiHcRED-MAL) in the plasma membrane of COS7 cells and antibody-mediated cross-linking of FLAG-tagged MAL—laterally concentrate markers of sphingolipid rafts and exclude a fluorescent analogue of phosphatidylethanolamine. Site-directed mutagenesis and bimolecular fluorescence complementation analysis demonstrate that MAL forms oligomers via ϕxxϕ intramembrane protein–protein binding motifs. Furthermore, results from membrane modulation by using exogenously added cholesterol or ceramides support the hypothesis that MAL-mediated association with raft lipids is driven at least in part by positive hydrophobic mismatch between the lengths of the transmembrane helices of MAL and membrane lipids. These data place MAL as a key component in the organization of membrane domains that could potentially serve as membrane sorting platforms. PMID:19553470

  5. Discovery of an auto-regulation mechanism for the maltose ABC transporter MalFGK2.

    PubMed

    Bao, Huan; Duong, Franck

    2012-01-01

    The maltose transporter MalFGK(2), together with the substrate-binding protein MalE, is one of the best-characterized ABC transporters. In the conventional model, MalE captures maltose in the periplasm and delivers the sugar to the transporter. Here, using nanodiscs and proteoliposomes, we instead find that MalE is bound with high-affinity to MalFGK2 to facilitate the acquisition of the sugar. When the maltose concentration exceeds the transport capacity, MalE captures maltose and dissociates from the transporter. This mechanism explains why the transport rate is high when MalE has low affinity for maltose, and low when MalE has high affinity for maltose. Transporter-bound MalE facilitates the acquisition of the sugar at low concentrations, but also captures and dissociates from the transporter past a threshold maltose concentration. In vivo, this maltose-forced dissociation limits the rate of transport. Given the conservation of the substrate-binding proteins, this mode of allosteric regulation may be universal to ABC importers.

  6. The electronic structure and the ferromagnetic properties of [Cu(mal)(DMF)] n(mal=malonate dianion, DMF= N, N-dimethylformamide)

    NASA Astrophysics Data System (ADS)

    Yao, K. L.; Zhang, J. Q.; Liu, Z. L.; Gao, G. Y.; Li, Y. L.; Xi, D.; Ning, Q.

    We present first-principles study on the magnetic properties of the 3D metal-ligand coordination polymer [Cu(mal)(DMF)] n within the framework of density functional theory (DFT) by using the full-potential linearized augmented plane-wave (FP-LAPW) method. The total and partial density of states (DOS), the band structure, and the atomic spin magnetic moment of [Cu(mal)(DMF)] n are calculated. The calculation reveals that [Cu(mal)(DMF)] n is a ferromagnetic semiconductor. The calculated spin magnetic moment is about 1.000 μB per molecule, which is in agreement with experimental value.

  7. Developmental expression of the SRF co-activator MAL in brain: role in regulating dendritic morphology.

    PubMed

    Shiota, Jun; Ishikawa, Mitsuru; Sakagami, Hiroyuki; Tsuda, Masaaki; Baraban, Jay M; Tabuchi, Akiko

    2006-09-01

    The dynamic changes in dendritic morphology displayed by developing and mature neurons have stimulated interest in deciphering the signaling pathways involved. Recent studies have identified megakaryocytic acute leukemia (MAL), a serum response factor (SRF) co-activator, as a key component of a signaling pathway linking changes in the actin cytoskeleton to SRF-mediated transcription. To help define the role of this pathway in regulating dendritic morphology, we have characterized the pattern of MAL expression in the developing and adult brain, and have examined its role in regulating dendritic morphology in cultured cortical neurons. In histological studies of mouse brain, we found prominent expression of MAL in neurons in adult hippocampus and cerebral cortex. MAL immunostaining revealed localization of this protein in neuronal cell bodies and apical dendrites. During development, an increase in MAL expression occurs during the second post-natal week. Expression of dominant negative MAL constructs or MAL siRNA in cortical neurons grown in primary culture reduces the number of dendritic processes and decreases the basal level of SRF-mediated transcription. Taken together, these findings indicate that the MAL-SRF signaling pathway plays a key role in regulating dendritic morphology.

  8. MAL/VIP17, a New Player in the Regulation of NKCC2 in the Kidney

    PubMed Central

    Rizzo, Federica; Procino, Giuseppe; Basco, Davide; Valenti, Giovanna; Forbush, Biff; Schaeren-Wiemers, Nicole; Caplan, Michael J.; Svelto, Maria

    2010-01-01

    The renal-specific Na+-K+-2Cl− cotransporter (NKCC2) is the major salt transport pathway of the apical membrane of the mammalian thick ascending limb of Henle's loop. Here, we analyze the role of the tetraspan protein myelin and lymphocytes-associated protein (MAL)/VIP17 in the regulation of NKCC2. We demonstrated that 1) NKCC2 and MAL/VIP17 colocalize and coimmunoprecipitate in Lilly Laboratories cell porcine kidney cells (LLC-PK1) as well as in rat kidney medullae, 2) a 150-amino acid stretch of NKCC2 C-terminal tail is involved in the interaction with MAL/VIP17, 3) MAL/VIP17 increases the cell surface retention of NKCC2 by attenuating its internalization, and 4) this coincides with an increase in cotransporter phosphorylation. Interestingly, overexpression of MAL/VIP17 in the kidney of transgenic mice results in cysts formation in distal nephron structures consistent with the hypothesis that MAL/VIP17 plays an important role in apical sorting or in maintaining the stability of the apical membrane. The NKCC2 expressed in these mice was highly glycosylated and phosphorylated, suggesting that MAL/VIP17 also is involved in the stabilization of NKCC2 at the apical membrane in vivo. Thus, the involvement of MAL/VIP17 in the activation and surface expression of NKCC2 could play an important role in the regulated absorption of Na+ and Cl− in the kidney. PMID:20861303

  9. [Clonage of the "malA" region of "Escherichia coli" K12: nucleotide sequence of the regulatory region and the promoters, identification and purification of the MalT-activator protein (author's transl)].

    PubMed

    Raibaud, O; Débarbouillé, M; Cossart, P

    1982-01-01

    A 5,800-bp (base pair) HindIII-EcoRI DNA fragment containing malT, the positive regulator gene of the maltose regulon, and most of malP, the structural gene for maltodextrin phosphorylase, was cloned into pBR322. A sequence of 802 bp was established in a DNA segment containing the promotor for malPQ and the promoter for malT. A total of 611 bp separates the initiation codons for these two genes, which are transcribed in opposite directions. The malT product was identified as a 94,000 dalton polypeptide.

  10. Identification and characterization of MalA in the maltose/maltodextrin operon of Sulfolobus acidocaldarius DSM639.

    PubMed

    Choi, Kyoung-Hwa; Hwang, Sungmin; Cha, Jaeho

    2013-04-01

    A putative maltose/maltodextrin operon was found in the Sulfolobus acidocaldarius DSM639 genome. The gene cluster consisted of 7 genes (malA, trmB, amyA, malG, malF, malE, and malK). Here, we report the identification of MalA, which is responsible for the hydrolysis of maltose or maltodextrin to glucose in S. acidocaldarius. The transcription level of malA was increased 3-fold upon the addition of maltose or starch to the medium. Moreover, the α-glucosidase activity for maltose as a substrate in cell extracts of S. acidocaldarius DSM639 was also 11- and 10-fold higher during growth in YT medium (Brock's mineral salts, 0.1% [wt/vol] tryptone, and 0.005% [wt/vol] yeast extract) containing maltose or starch, respectively, than during growth on other sugars. The gene encoding MalA was cloned and expressed in S. acidocaldarius. The enzyme purified from the organism was a dodecamer in its active state and showed strong maltose-hydrolyzing activity at 100°C and pH 5.0. MalA was remarkably thermostable, with half-lives of 33.8 h, 10.6 h, and 1.8 h at 95°C, 100°C, and 105°C, respectively. Substrate specificity and kinetic studies of MalA with maltooligosaccharides indicated that MalA efficiently hydrolyzed maltose to maltopentaose, which is a typical characteristic of GH31-type α-glucosidases. However, glycogen or starch was not hydrolyzed. Reverse transcription-PCR, sugar uptake, and growth studies of the wild-type DSM639 and ΔmalEFG mutant on different sugars demonstrated that MalA located in the mal operon gene cluster is involved in maltose and starch metabolism in S. acidocaldarius.

  11. Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies

    PubMed Central

    Musazzi, Laura; Marrocco, Jordan

    2016-01-01

    Environmental stressors induce coping strategies in the majority of individuals. The stress response, involving the activation of the hypothalamic-pituitary-adrenocortical axis and the consequent release of corticosteroid hormones, is indeed aimed at promoting metabolic, functional, and behavioral adaptations. However, behavioral stress is also associated with fast and long-lasting neurochemical, structural, and behavioral changes, leading to long-term remodeling of glutamate transmission, and increased susceptibility to neuropsychiatric disorders. Of note, early-life events, both in utero and during the early postnatal life, trigger reprogramming of the stress response, which is often associated with loss of stress resilience and ensuing neurobehavioral (mal)adaptations. Indeed, adverse experiences in early life are known to induce long-term stress-related neuropsychiatric disorders in vulnerable individuals. Here, we discuss recent findings about stress remodeling of excitatory neurotransmission and brain morphology in animal models of behavioral stress. These changes are likely driven by epigenetic factors that lie at the core of the stress-response reprogramming in individuals with a history of perinatal stress. We propose that reprogramming mechanisms may underlie the reorganization of excitatory neurotransmission in the short- and long-term response to stressful stimuli. PMID:27057367

  12. malB region in Escherichia coli K-12: specialized transducing bacteriophages and first restriction map.

    PubMed Central

    Marchal, C; Greenblatt, J; Hofnung, M

    1978-01-01

    By starting from an Escherichia coli K-12 strain with a lambda phage integrated in the malB region, series of transducing phages carrying part or all of the malB region have been isolated. Genetic mapping of the transduced malB fragments was accomplished by complementation and recombination with known mutations in the region. By using the DNA of these phages, it was found that the malB region is cleaved by the restriction enzymes BglII, EcoRI, HaeII, HincII, SalI, and SstI, but not BamHI, HindIII, KpnI, PstI, XbaI, or XhoI. A physical map was constructed and tentatively correlated with the genetic map. Images PMID:363689

  13. Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells.

    PubMed

    Ventimiglia, Leandro N; Fernández-Martín, Laura; Martínez-Alonso, Emma; Antón, Olga M; Guerra, Milagros; Martínez-Menárguez, José Angel; Andrés, Germán; Alonso, Miguel A

    2015-08-01

    Exosomes secreted by T cells play an important role in coordinating the immune response. HIV-1 Nef hijacks the route of exosome secretion of T cells to modulate the functioning of uninfected cells. Despite the importance of the process, the protein machinery involved in exosome biogenesis is yet to be identified. In this study, we show that MAL, a tetraspanning membrane protein expressed in human T cells, is present in endosomes that travel toward the plasma membrane for exosome secretion. In the absence of MAL, the release of exosome particles and markers was greatly impaired. This effect was accompanied by protein sorting defects at multivesicular endosomes that divert the exosomal marker CD63 to autophagic vacuoles. Exosome release induced by HIV-1 Nef was also dependent on MAL expression. Therefore, MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells.

  14. MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

    PubMed Central

    Bijlard, Marjolein; de Jonge, Jenny C.; Klunder, Bert; Nomden, Anita; Hoekstra, Dick; Baron, Wia

    2016-01-01

    In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its premature compaction. MAL is a well-known regulator of polarized trafficking in epithelial cells, and given its presence in OLGs it was therefore of interest to investigate whether MAL played a similar role in PLP transport in OLGs, taking into account its timely expression in these cells. Our data revealed that premature expression of mCherry-MAL in oligodendrocyte progenitor cells interfered with terminal OLG differentiation, although myelin membrane formation per se was not impaired. In fact, also PLP transport to myelin membranes via the cell body plasma membrane was unaffected. However, the typical shift of PLP from TX-100-insoluble membrane domains to CHAPS-resistant, but TX-100-soluble membrane domains, seen in the absence of MAL expression, is substantially reduced upon expression of the MAL protein. Interestingly, not only in vitro, but also in developing brain a strongly diminished shift from TX-100 resistant to TX-100 soluble domains was observed. Consistently, the MAL-expression mediated annihilation of the typical membrane microdomain shift of PLP is also reflected by a loss of the characteristic surface expression profile of conformation-sensitive anti-PLP antibodies. Hence, these findings suggest that MAL is not involved in vesicular PLP trafficking to either the plasma membrane and/or the myelin membrane as such. Rather, we propose that MAL may regulate PLP’s distribution into distinct membrane microdomains that allow for lateral diffusion of PLP, directly from the plasma membrane to the myelin membrane once the myelin sheath has been assembled. PMID:27171274

  15. Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2.

    PubMed

    Weng, Jingwei; Gu, Shuo; Gao, Xin; Huang, Xuhui; Wang, Wenning

    2017-04-05

    Maltose transporter MalFGK2 is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily. Upon the binding of its periplasmic binding protein, MalE, the ATPase activity of MalFGK2 can be greatly enhanced. Crystal structures of the MalFGK2-MalE-maltose complex in a so-called "pretranslocation" ("pre-T") state with a partially closed conformation suggest that the formation of this MalE-stabilized intermediate state is a key step leading to the outward-facing catalytic state. On the contrary, crosslinking and fluorescence studies suggest that ATP binding alone is sufficient to promote the outward-facing catalytic state, thereby doubting the role of MalE binding. To clarify the role of MalE binding and to gain deeper understanding of the molecular mechanisms of MalFGK2, we calculated the free energy surfaces (FESs) related to the lateral motion in the presence and absence of MalE using atomistic metadynamics simulations. The results showed that, in the absence of MalE, laterally closing motion was energetically forbidden but, upon MalE binding, more closed conformations similar to the pre-T state become more stable. The significant effect of MalE binding on the free energy landscapes was in agreement with crystallographic studies and confirmed the important role of MalE in stabilizing the pre-T state. Our simulations also revealed that the allosteric effect of MalE stimulation originates from the MalE-binding-promoted vertical motion between MalF and MalG cores, which was further supported by MD simulation of the MalE-independent mutant MalF500.

  16. Regulatory Information By Sector

    EPA Pesticide Factsheets

    Find environmental regulatory, compliance, & enforcement information for various business, industry and government sectors, listed by NAICS code. Sectors include agriculture, automotive, petroleum manufacturing, oil & gas extraction & other manufacturing

  17. Substrate transport activation is mediated through second periplasmic loop of transmembrane protein MalF in maltose transport complex of Escherichia coli.

    PubMed

    Jacso, Tomas; Schneider, Erwin; Rupp, Bernd; Reif, Bernd

    2012-05-18

    In a recent study we described the second periplasmic loop P2 of the transmembrane protein MalF (MalF-P2) of the maltose ATP-binding cassette transporter (MalFGK(2)-E) as an important element in the recognition of substrate by the maltose-binding protein MalE. In this study, we focus on MalE and find that MalE undergoes a structural rearrangement after addition of MalF-P2. Analysis of residual dipolar couplings (RDCs) shows that binding of MalF-P2 induces a semiopen state of MalE in the presence and absence of maltose, whereas maltose is retained in the binding pocket. These data are in agreement with paramagnetic relaxation enhancement experiments. After addition of MalF-P2, an increased solvent accessibility for residues in the vicinity of the maltose-binding site of MalE is observed. MalF-P2 is thus not only responsible for substrate recognition, but also directly involved in activation of substrate transport. The observation that substrate-bound and substrate-free MalE in the presence of MalF-P2 adopts a similar semiopen state hints at the origin of the futile ATP hydrolysis of MalFGK(2)-E.

  18. Structure of the Major Apple Allergen Mal d 1

    PubMed Central

    2017-01-01

    More than 70% of birch pollen-allergic patients develop allergic cross-reactions to the major allergen found in apple fruits (Malus domestica), the 17.5 kDa protein Mal d 1. Allergic reactions against this protein result from initial sensitization to the major allergen from birch pollen, Bet v 1. Immunologic cross-reactivity of Bet v 1-specific IgE antibodies with Mal d 1 after apple consumption can subsequently provoke severe oral allergic syndromes. This study presents the three-dimensional NMR solution structure of Mal d 1 (isoform Mal d 1.0101, initially cloned from ‘Granny Smith’ apples). This protein is composed of a seven-stranded antiparallel β-sheet and three α-helices that form a large internal cavity, similar to Bet v 1 and other cross-reactive food allergens. The Mal d 1 structure provides the basis for elucidating the details of allergic cross-reactivity between birch pollen and apple allergens on a molecular level. PMID:28161953

  19. The bacterial flora of the skin surface following routine MAL-PDT.

    PubMed

    Bryld, Lars Eeik; Jemec, Gregor B E

    2006-01-01

    Photodynamic therapy using methylated 5-aminolevulate (MAL-PDT) appears to have an effect on non-neoplastic skin diseases, for example acne vulgaris and rosacea, for which antibiotics are sometimes used, and a possible antibiotic effect of PDT has previously been suggested. It does, however, also cause local immunosuppression and post-treatment barrier defects, which may promote infection. At the same time, PDT-induced therapeutic skin damage is sometimes confused with secondary bacterial infection by non-dermatologists. The possible changes in bacterial flora associated with MAL-PDT were therefore studied in 47 patients undergoing treatment. Skin swabs were taken immediately before applying the MAL and instantly after light irradiation. Bacterial growth was identified in 18 cases. No statistically significant changes were seen, either in the specific species found or the estimated bacterial density on the skin surface. The observations do not support the notion that routine MAL-PDT affects the bacterial flora of the skin in a clinically significant manner. Therefore, the possible antibacterial effect of routine MAL-PDT is probably not the main explanation of its apparent effect on non-neoplastic skin disease.

  20. Structural Basis for the Interconversion of Maltodextrins by MalQ, the Amylomaltase of Escherichia coli*

    PubMed Central

    Weiss, Simon C.; Skerra, Arne; Schiefner, André

    2015-01-01

    Amylomaltase MalQ is essential for the metabolism of maltose and maltodextrins in Escherichia coli. It catalyzes transglycosylation/disproportionation reactions in which glycosyl or dextrinyl units are transferred among linear maltodextrins of various lengths. To elucidate the molecular basis of transglycosylation by MalQ, we have determined three crystal structures of this enzyme, i.e. the apo-form, its complex with maltose, and an inhibitor complex with the transition state analog acarviosine-glucose-acarbose, at resolutions down to 2.1 Å. MalQ represents the first example of a mesophilic bacterial amylomaltase with known structure and exhibits an N-terminal extension of about 140 residues, in contrast with previously described thermophilic enzymes. This moiety seems unique to amylomaltases from Enterobacteriaceae and folds into two distinct subdomains that associate with different parts of the catalytic core. Intriguingly, the three MalQ crystal structures appear to correspond to distinct states of this enzyme, revealing considerable conformational changes during the catalytic cycle. In particular, the inhibitor complex highlights the requirement of both a 3-OH group and a 4-OH group (or α1–4-glycosidic bond) at the acceptor subsite +1 for the catalytically competent orientation of the acid/base catalyst Glu-496. Using an HPLC-based MalQ enzyme assay, we could demonstrate that the equilibrium concentration of maltodextrin products depends on the length of the initial substrate; with increasing numbers of glycosidic bonds, less glucose is formed. Thus, both structural and enzymatic data are consistent with the extremely low hydrolysis rates observed for amylomaltases and underline the importance of MalQ for the metabolism of maltodextrins in E. coli. PMID:26139606

  1. Spatio-temporal analysis of human electroencephalograms: Petit-mal epilepsy

    NASA Astrophysics Data System (ADS)

    Friedrich, R.; Uhl, C.

    An analysis of multigrid electroencephalograms (EEG) derived from two different persons suffering from petit-mal epilepsy is performed. Using a previously devised method for analyzing spatio-temporal patterns (Uhl, et al., Z. Phys. B 92 (1993) 211-219), we find a suitable mode decomposition of the EEG. Additionally, we are able to extract a three-dimensional dynamical system which describes the dynamics of the patterns as a kind of mode interaction. We show that the spike-wave behavior characteristic for petit-mal epilepsy arising in the dynamical system is related with Sil'nikov-type behavior of the mode dynamics.

  2. Expression of the Escherichia coli malPQ operon remains unaffected after drastic alteration of its promoter.

    PubMed Central

    Débarbouillé, M; Raibaud, O

    1983-01-01

    The malPQ operon, one of the three operons of the maltose regulon, is positively controlled by the product of gene malT. The starting point for malPQ transcription was deduced from experiments which involved a hybridization of in vivo-synthesized malPQ mRNA with adequate DNA probes, followed either by a digestion of nonhybridized DNA (S1 nuclease mapping) or by an extension of the hybridized probe (reverse transcriptase mapping). In the wild-type strain, this starting point was 37 nucleotides upstream from the initiation codon for malP. This analysis was also performed on a double mutant which contained both a 13-base pair deletion and a 3-base pair insertion in the promoter region. This double mutant expressed the malPQ operon exactly as the wild-type strain did, in a maltose-inducible manner. In this strain, the starting point for malPQ transcription was shifted 11 nucleotides downstream from the wild-type location. An analysis of these results suggests that (i) the binding site for the malT product is located upstream from the region which is severely altered in the double mutant, i.e., upstream from position -31; and (ii) the 30-base pair sequence which precedes the transcription starting point contains very few positions which are essential for promoter activity. Images PMID:6186658

  3. Rising Mal-Employment and the Great Recession: The Growing Disconnection between Recent College Graduates and the College Labor Market

    ERIC Educational Resources Information Center

    Fogg, Neeta P.; Harrington, Paul E.

    2011-01-01

    This article looks at the phenomenon of mal-employment among college graduates in the United States, beginning with an overview of labor-market trends and the effects of the Great Recession on the job-market experiences of young people, including recent college graduates. It then defines "mal-employment" and examines its incidence over…

  4. Apple (Malus domestica L. Borkh.) allergen Mal d 1: effect of cultivar, cultivation system, and storage conditions.

    PubMed

    Matthes, Anne; Schmitz-Eiberger, Michaela

    2009-11-25

    It has been reported on the basis of skin prick tests and gene expression studies that apple cultivars differ in their allergenic potential. Only a few studies have tried to measure the amount of the major apple allergen Mal d 1 so far. Mal d 1 belongs to the pathogenesis-related proteins, a family of proteins that are induced by pathogens and environmental stress. Due to cross-reactivity between Bet v 1 and proteins present in several plant-derived foods, birch pollen allergic patients develop food allergies, most frequently to apples. Mal d 1 content was quantified in different apple cultivars, cultivated at the research stations Klein-Altendorf and Bavendorf, dependent on cultivation method and storage conditions by sandwich-ELISA. Apple cultivars differ considerably in their Mal d 1 content. A high variability in Mal d 1 content was determined within one cultivar and between the two locations for the same apple cultivar. In most cases organically cultivated fruit showed lower Mal d 1 content in comparison to fruit from integrated production. At harvest the detected concentration of Mal d 1 was low, but during storage the Mal d 1 content increased significantly.

  5. Change in Myself-as-a-Learner Scale (MALS) Scores as Pupils Transfer to and Progress through Secondary School

    ERIC Educational Resources Information Center

    Norgate, Roger; Osborne, Cara; Warhurst, Amy

    2013-01-01

    Longitudinal changes in pupils' academic self-perception (as measured by Myself-As-a-Learner Scale [MALS]) were investigated between Year 6 and Year 10. The possibility of there being gender and attainment differences was also explored. There was a significant drop in mean MALS scores between Years 6 and 7. There was a further drop between Years 7…

  6. Outcomes and treatments of mal fractures caused by the split-crest technique in the mandible.

    PubMed

    Shibuya, Yasuyuki; Yabase, Akiko; Ishida, Suguru; Kobayashi, Masaki; Komori, Takahide

    2014-09-26

    In this study, we investigated cases of mal fracture occurring during the split-crest procedure. In all subjects (six patients), the free cortical bone segment caused by the mal fracture was carefully maintained in the lateral position without fixation using a titanium plate or screw. On pre- and postoperative multiplanar reconstruction CT, the average total alveolar increase was 5.0 mm in the lower portion 1 mm from the top of the alveolar ridge, and the average total alveolar increase in the lower portion 11 mm from the top of the alveolar ridge was 2.2 mm. A total of 11 dental implants were placed immediately at the same time as the split-crest procedure, while three dental implants were placed after a waiting period of 4-11 months from bone augmentation. During an average follow-up of 27.8 months, there were no complications or cases of failed implants. Consequently, among the patients who experienced mal fracture during the split-crest technique, a sufficient volume of alveolar bone was obtained without the need for rigid fixation of the free bone segment, and the dental implants placed within the area of the mal fracture showed a good prognosis.

  7. Crystal growth and characterization of LaMAl 11O 19 lanthanum aluminates

    NASA Astrophysics Data System (ADS)

    Laville, F.; Lejus, A. M.

    1983-10-01

    New magnetoplumbite-type lanthanum aluminates with the formula LaMAl 11O 19 (M 2+ = Ni 2+, Co 2+, Fe 2+, Mg 1- xMn x, 0≤ x ≤1, have been grown as large single crystals using the Verneuil process or the floating zone method. Some characteristics of these crystals are given.

  8. Mal de Meleda in Indonesia: Mutations in the SLURP1 gene appear to be ubiquitous.

    PubMed

    Taylor, Jessica A; Bondavalli, Davide; Monif, Mastura; Yap, Lee Mei; Winship, Ingrid

    2016-02-01

    Mal de Meleda is a rare autosomal recessive genodermatosis caused by mutations in the ARS B (SLURP1) gene, with possible founder effects in the Mediterranean and Adriatic regions. We report an affected individual from Indonesia without known consanguinity in the family, suggesting that SLURP1 gene mutations are ubiquitous. Recognition of the phenotype can be confirmed by genetic testing, thus facilitating genetic counselling.

  9. The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling.

    PubMed

    Sheedy, Frederick J; O'Neill, Luke A J

    2007-08-01

    Signaling by two of the most important bacteria-sensing TLRs, TLR2 and TLR4, involves two adaptor proteins, MyD88 adaptor-like (Mal) and Toll/IL-1 receptor (TIR) domain-containing adaptor-inducing IFN-beta (Trif)-related adaptor molecule (TRAM). Recently, new insights into the functioning of these two adapters have emerged. Mal is required by both TLRs to act as a bridge to recruit the adaptor MyD88, leading ultimately to NF-kappaB activation. Similarly, TRAM acts as a bridge to recruit TRIF to the TLR4 complex, leading to activation of the transcription factor IFN regulatory factor 3. Consistent with Mal and TRAM being key points of control, recent evidence suggests that they are subject to regulation by phosphorylation. Further, a variant in Mal in humans has been found to protect against multiple infectious diseases. Finally, another TIR domain-containing adaptor, sterile alpha and HEAT/armadillo motif protein (SARM), has been shown to act as an inhibitor of TRIF-dependent signaling. These recent discoveries add to the complexity of TLR signaling and highlight specific control mechanisms for TLR2 and TLR4 signaling.

  10. Comparison of the MTT1- and MAL31-like maltose transporter genes in lager yeast strains.

    PubMed

    Dietvorst, Judith; Walsh, Mike C; van Heusden, G Paul H; Steensma, H Yde

    2010-09-01

    Maltose transporter genes were isolated from four lager yeast strains and sequenced. All four strains contain at least two different types of maltose transporter genes, MTT1 and MAL31. In addition, 'long' 2.7 kb, and 'short' 2.4 kb, versions of each type exist. The size difference is caused by the insertion of two repeats of 147 bp into the promoter regions of the long versions of the genes. As a consequence of the insertion, two Mal63-binding sites move 294 bp away from the transcription initiation site. The 2.4- and 2.7-kb versions are further highly similar. Only the 2.4-kb versions and not the 2.7-kb versions of MTT1 could restore the rapid growth of lager yeast strain A15 on maltotriose in the presence of antimycin A. These results suggest that insertion of the two repeats into the promoter region of the 'long versions' of MTT1 genes led to a diminished expression of these genes. None of the tested long and short versions of the MAL31 genes were able to restore this growth. As the promoter regions of the MTT1 and MAL31 genes are identical, small differences in the protein sequence may be responsible for the different properties of these genes.

  11. Structural and mutational analyses of Aes, an inhibitor of MalT in Escherichia coli.

    PubMed

    Schiefner, André; Gerber, Kinga; Brosig, Alexander; Boos, Winfried

    2014-02-01

    The acyl esterase Aes effectively inhibits the transcriptional activity of MalT-the central activator of maltose and maltodextrin utilizing genes in Escherichia coli. To provide better insight into the nature of the interaction between Aes and MalT, we determined two different crystal structures of Aes-in its native form and covalently modified by a phenylmethylsulfonyl moiety at its active site serine. Both structures show distinct space groups and were refined to a resolution of 1.8 Å and 2.3 Å, respectively. The overall structure of Aes resembles a canonical α/β-hydrolase fold, which is extended by a funnel-like cap structure that forms the substrate-binding site. The catalytic triad of Aes, comprising residues Ser165, His292, and Asp262, is located at the bottom of this funnel. Analysis of the crystal-packing contacts of the two different space groups as well as analytical size-exclusion chromatography revealed a homodimeric arrangement of Aes. The Aes dimer adopts an antiparallel contact involving both the hydrolase core and the cap, with its twofold axis perpendicular to the largest dimension of Aes. To identify the surface area of Aes that is responsible for the interaction with MalT, we performed a structure-based alanine-scanning mutagenesis to pinpoint Aes residues that are significantly impaired in MalT inhibition, but still exhibit wild-type expression and enzymatic activity. These residues map to a shallow slightly concave surface patch of Aes at the opposite site of the dimerization interface and indicate the surface area that interacts with MalT.

  12. Characterization of Saccharomyces cerevisiae strains from spontaneously fermented maize dough by profiles of assimilation, chromosome polymorphism, PCR and MAL genotyping.

    PubMed

    Hayford, A E; Jespersen, L

    1999-02-01

    Several isolates of Saccharomyces cerevisiae from indigenous spontaneously fermented maize dough have been characterized with the purpose of selecting appropriate starter cultures and methods for their subspecies typing. The techniques applied included assimilation of carbon compounds by the API ID 32 C kit, determination of chromosome profiles by PFGE, PCR and MAL genotyping. For the 48 isolates investigated, use of the API ID 32 C kit resulted in eight different assimilation profiles. The most common assimilation profile was the ability of 50% of the isolates to assimilate galactose, saccharose, DL-lactate, raffinose, maltose and glucose. Both chromosome and PCR profiles could be used for subspecies typing of the isolates and on this basis, the isolates were grouped into clusters. The discriminative power of the two techniques was equal; a few isolates not separated by their chromosome profiles could be separated by their PCR profiles and vice versa. Four different MAL genotypes were observed with MAL11 and MAL31 predominating. MAL11 was seen for all isolates whereas no evidence of MAL21 and MAL41 was observed. Based on the results obtained, a high number of Saccharomyces cerevisiae isolates were found to be involved throughout the spontaneous fermentation of maize dough. All methods included appeared to be suitable for subspecies typing. However, the discriminative power was highest for the PFGE and PCR techniques.

  13. Impact of sulfur and vitamin C on the allergenicity of Mal d 2 from apple (Malus domestica).

    PubMed

    Marzban, Gorji; Kinaciyan, Tamar; Maghuly, Fatemeh; Brunner, Richard; Gruber, Clemens; Hahn, Rainer; Jensen-Jarolim, Erika; Laimer, Margit

    2014-07-30

    Mal d 2 is a minor allergen from apple which shows a high conformational stability due to its eight conserved disulfide bridges. Chemical reduction of disulfide bridges and linearization of Mal d 2 lead to enhanced IgE reactivity in vitro and indicate a higher potential for allergenicity. Since food preservatives such as sulfur and vitamin C are reducing and denaturing agents, their influence on Mal d 2 allergenicity was verified by simulated food processing conditions. The immunoreactivity of purified Mal d 2 was investigated after different treatments in vitro and in vivo using IgG/IgE Western blotting, mediator-releasing cell assay, and skin prick and oral smear tests. The conformational changes of Mal d 2 upon addition of 1% and 5% vitamin C were also monitored by attenuated total reflectance Fourier transform infrared spectroscopy. The results show no positive skin and oral smear test reactivity to native, heated, or vitamin C-treated purified Mal d 2. Furthermore, the results confirm that sulfur in combination with heat treatment can influence the structural integrity and thus the allergenicity of Mal d 2, while vitamin C is too weak as a reducing agent to change allergenicity.

  14. Serine/threonine kinase 16 and MAL2 regulate constitutive secretion of soluble cargo in hepatic cells.

    PubMed

    In, Julie G; Striz, Anneliese C; Bernad, Antonio; Tuma, Pamela L

    2014-10-15

    MAL2 (myelin and lymphocyte protein 2) is thought to regulate at least two steps in the hepatic apical transcytotic pathway. As vesicle budding and delivery at each step are driven by complex machineries, we predicted that MAL2 participates in several large protein complexes with multiple binding partners. To identify novel MAL2 interactors, we performed split-ubiquitin yeast two-hybrid assays and identified STK16 (serine/threonine kinase 16) as a putative interactor which we verified morphologically and biochemically. As STK16 is a Golgi-associated constitutively active kinase implicated in regulating secretion and because of the massive constitutive secretory capacity of hepatic cells, we tested whether MAL2 and STK16 function in secretion. Expression of a dominant-negative kinase-dead STK16 mutant (E202A) or knockdown of MAL2 impaired secretion that correlated with decreased expression of albumin and haptoglobin. By using 19°C temperature blocks and lysosome deacidification, we determined that E202A expression or MAL2 knockdown did not interfere with albumin synthesis or processing, but led to albumin lysosomal degradation. We conclude that MAL2 and the constitutively active STK16 function to sort secretory soluble cargo into the constitutive secretory pathway at the TGN (trans-Golgi network) in polarized hepatocytes.

  15. The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin

    PubMed Central

    Oo, Myat Lin; Anrather, Josef; Schaeren-Wiemers, Nicole; Alonso, Miguel A.; Fischetti, Vincent A.; McClain, Mark S.; Vartanian, Timothy

    2015-01-01

    Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injury. ETX has been proposed as a potential causative agent for Multiple Sclerosis (MS), a human disease that begins with BBB breakdown and injury to myelin forming cells of the CNS. The receptor for ETX is unknown. Here we show that both binding of ETX to mammalian cells and cytotoxicity requires the tetraspan proteolipid Myelin and Lymphocyte protein (MAL). While native Chinese Hamster Ovary (CHO) cells are resistant to ETX, exogenous expression of MAL in CHO cells confers both ETX binding and susceptibility to ETX-mediated cell death. Cells expressing rat MAL are ~100 times more sensitive to ETX than cells expressing similar levels of human MAL. Insertion of the FLAG sequence into the second extracellular loop of MAL abolishes ETX binding and cytotoxicity. ETX is known to bind specifically and with high affinity to intestinal epithelium, renal tubules, brain endothelial cells and myelin. We identify specific binding of ETX to these structures and additionally show binding to retinal microvasculature and the squamous epithelial cells of the sclera in wild-type mice. In contrast, there is a complete absence of ETX binding to tissues from MAL knockout (MAL-/-) mice. Furthermore, MAL-/- mice exhibit complete resistance to ETX at doses in excess of 1000 times the symptomatic dose for wild-type mice. We conclude that MAL is required for both ETX binding and cytotoxicity. PMID:25993478

  16. The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin.

    PubMed

    Rumah, Kareem Rashid; Ma, Yinghua; Linden, Jennifer R; Oo, Myat Lin; Anrather, Josef; Schaeren-Wiemers, Nicole; Alonso, Miguel A; Fischetti, Vincent A; McClain, Mark S; Vartanian, Timothy

    2015-05-01

    Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injury. ETX has been proposed as a potential causative agent for Multiple Sclerosis (MS), a human disease that begins with BBB breakdown and injury to myelin forming cells of the CNS. The receptor for ETX is unknown. Here we show that both binding of ETX to mammalian cells and cytotoxicity requires the tetraspan proteolipid Myelin and Lymphocyte protein (MAL). While native Chinese Hamster Ovary (CHO) cells are resistant to ETX, exogenous expression of MAL in CHO cells confers both ETX binding and susceptibility to ETX-mediated cell death. Cells expressing rat MAL are ~100 times more sensitive to ETX than cells expressing similar levels of human MAL. Insertion of the FLAG sequence into the second extracellular loop of MAL abolishes ETX binding and cytotoxicity. ETX is known to bind specifically and with high affinity to intestinal epithelium, renal tubules, brain endothelial cells and myelin. We identify specific binding of ETX to these structures and additionally show binding to retinal microvasculature and the squamous epithelial cells of the sclera in wild-type mice. In contrast, there is a complete absence of ETX binding to tissues from MAL knockout (MAL-/-) mice. Furthermore, MAL-/- mice exhibit complete resistance to ETX at doses in excess of 1000 times the symptomatic dose for wild-type mice. We conclude that MAL is required for both ETX binding and cytotoxicity.

  17. Mineral Processing Sector

    EPA Pesticide Factsheets

    Find environmental regulatory and compliance information for the nonmetallic mineral processing sector (NAICS 327), including NESHAPs for asbestos and hazardous waste, and wastewater permit information.

  18. Ferromagnetic coupling in the three-dimensional malonato-bridged gadoliniumIII complex [Gd2(mal)3(H2O)6] (H2mal = malonic acid).

    PubMed

    Hernández-Molina, María; Ruiz-Pérez, Catalina; López, Trinidad; Lloret, Francesc; Julve, Miguel

    2003-09-08

    The novel gadolinium(III) complex of formula [Gd(2)(mal)(3)(H(2)O)(6)] (1) (H(2)mal = 1,3-propanedioic acid) has been prepared and characterized by X-ray diffraction analysis. Crystal data for 1: monoclinic, space group I2/a, a = 11.1064(10) A, b = 12.2524(10) A, c =13.6098(2) A, beta = 92.925(10) degrees, U = 1849.5(3) A(3), Z = 4. Compound 1 is a three-dimensional network made up of malonate-bridged gadolinium(III) ions where the malonate exhibits two bridging modes, eta(5)-bidentate + unidentate and eta(3):eta(3) + bis(unidentate). The gadolinium atom is nine-coordinate with three water molecules and six malonate oxygen atoms from three malonate ligands forming a distorted monocapped square antiprism. The shortest metal-metal separations are 4.2763(3) A [through the oxo-carboxylate bridge] and 6.541(3) A [through the carboxylate in the anti-syn coordination mode]. The value of the angle at the oxo-carboxylate atom is 116.8(2) degrees. Variable-temperature magnetic susceptibility measurements reveal the occurrence of a significant ferromagnetic interaction through the oxo-carboxylate pathway (J = +0.048(1) cm(-1), H = -JS(Gd(1)) x S(Gd(1a))).

  19. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    PubMed

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  20. Une localisation exceptionnelle de la tuberculose vertébrale Mal de Pott sous-occipital

    PubMed Central

    Yahyaoui, Sana; Majdoub, Senda; Zaghouani, Houneida; Fradj, Hosni Ben; Bakir, Dejla; Bouajina, Elyes; Kraiem, Chakib

    2013-01-01

    Le mal de Pott est la forme la plus commune de la tuberculose osseuse touchant essentiellement le rachis dorso-lombaire. La localisation sous-occipitale reste exceptionnelle. Le diagnostic de cette entité est le plus souvent tardif ce qui expose à des complications graves. Les radiographies standard ne sont parlantes qu’à un stade tardif de la maladie, d'où l'intérêt de l'imagerie moderne notamment la tomodensitométrie (TDM) et l'imagerie par résonance magnétique (IRM) qui permettent un diagnostic précoce. Nous rapportons un nouveau cas de tuberculose sous-occipitale. Le diagnostic était posé sur l'imagerie en coupe et confirmé histologiquement à la biopsie transorale. Sont rappelés les aspects en imagerie de cette localisation particulière du mal de Pott. PMID:23819005

  1. Maternal grand mal seizure leads to a surprising diagnosis of Dandy-Walker variant.

    PubMed

    Mendelson, Sherri G

    2011-01-01

    Pregnant women may present with abnormal symptoms that are assumed to be related to the pregnancy. The purpose of this case study is to examine an obstetric case that provides a wider view of a grand mal seizure in a perinatal patient with previously undiagnosed Dandy-Walker Variant. When a pregnant or newly postpartum woman has seizures, eclampsia may be the most the most likely diagnosis, but it may not be accurate.

  2. cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation.

    PubMed Central

    Alonso, M A; Weissman, S M

    1987-01-01

    We have isolated a human cDNA that is expressed in the intermediate and late stages of T-cell differentiation. The cDNA encodes a highly hydrophobic protein, termed MAL, that lacks a hydrophobic leader peptide sequence and contains four potential transmembrane domains separated by short hydrophilic segments. The predicted configuration of the MAL protein resembles the structure of integral proteins that form pores or channels in the plasma membrane and that are believed to act as transporters of water-soluble molecules and ions across the lipid bilayer. The presence of MAL mRNA in a panel of T-cell lines that express both the T-cell receptor and the T11 antigen suggests that MAL may be involved in membrane signaling in T cells activated via either T11 or T-cell receptor pathways. Images PMID:3494249

  3. Petit mal epilepsy and parkinsonian tremor: hypothesis of a common pacemaker.

    PubMed

    Buzsáki, G; Smith, A; Berger, S; Fisher, L J; Gage, F H

    1990-01-01

    Rhythmic oscillation in neuronal systems may serve physiological purposes or may interfere with normal functions of the brain. In disorders of petit mal epilepsy and parkinsonian tremor, centrally and peripherally observable rhythmic patterns are due to network oscillations of thalamocortical cells. This article reviews the afferent mechanisms that might be critically involved in controlling the ionic conductances of thalamic neurons in the behaving organism. We propose that during active behavior the subcortical aminergic and cholinergic inputs to the thalamus act as anti-burst and anti-oscillation mechanisms. We suggest further that the thalamopetal GABAergic inputs (pars reticulata of substantia nigra, entopeduncular nucleus, pallidum) are burst- and oscillation-promoting systems, whose output is controlled by the striatum. Experimental or disease-related decrease of the striatal dopamine levels is hypothesized to increase the efficacy of the GABAergic burst-promoting systems resulting in rhythmic network oscillation of thalamocortical neurons during rest. The recognition of the overlapping neuronal mechanisms in petit mal epilepsy and parkinsonian tremor, and the multistage control of thalamic oscillation suggests that drugs effectively used in petit mal attacks may be effective in levodopa-refractory parkinsonian tremor, and conversely, epileptic patients may benefit from drugs acting on the extrapyramidal system.

  4. The impact of catechin and epicatechin, total phenols and PPO activity on the Mal d 1 content in apple fruit.

    PubMed

    Kiewning, Daniela; Wollseifen, Rainer; Schmitz-Eiberger, Michaela

    2013-09-01

    The most important apple allergen in Central Europe and North America is Mal d 1. Apples are a very important source of secondary plant metabolites like polyphenols in human nutrition. It is known that oxidised phenols can bind proteins. These irreversible bindings can lead to a reduced allergenicity. The most important phenols in apple are epicatechin, catechin and their polymeric structures, which have been identified as substrates of the polyphenoloxidase (PPO). The aim of this study was to analyse the influence of naturally occurring catechin and epicatechin contents in apple on the allergenicity of apple fruits. Fruits of the cultivars 'Elstar', 'Diwa' and 'Boskoop' were harvested and stored for 8 and 12 weeks in a cold-chamber at 2 °C. Mal d 1-, catechin-, epicatechin- and total phenol content as well as the activity of PPO were determined. Correlation analysis showed that naturally occurring catechin as well as epicatechin has no impact on the Mal d 1 content of the tested cultivars: correlation coefficient ranged from -0.203 to 0.501 for the correlation between Mal d 1 and catechin. The results further indicated that the activity of PPO is more important than the content of total phenols to reduce the Mal d 1 level. If there is a high PPO activity, Mal d 1 could be reduced even if the total phenol concentration is low.

  5. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to the resurrected ancestor protein ancMALS of yeast maltases and isomaltases

    PubMed Central

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin; Aasamets, Anneli

    2016-01-01

    Abstract Saccharomyces cerevisiae maltases use maltose, maltulose, turanose and maltotriose as substrates, isomaltases use isomaltose, α‐methylglucoside and palatinose and both use sucrose. These enzymes are hypothesized to have evolved from a promiscuous α‐glucosidase ancMALS through duplication and mutation of the genes. We studied substrate specificity of the maltase protein MAL1 from an earlier diverged yeast, Ogataea polymorpha (Op), in the light of this hypothesis. MAL1 has extended substrate specificity and its properties are strikingly similar to those of resurrected ancMALS. Moreover, amino acids considered to determine selective substrate binding are highly conserved between Op MAL1 and ancMALS. Op MAL1 represents an α‐glucosidase in which both maltase and isomaltase activities are well optimized in a single enzyme. Substitution of Thr200 (corresponds to Val216 in S. cerevisiae isomaltase IMA1) with Val in MAL1 drastically reduced the hydrolysis of maltose‐like substrates (α‐1,4‐glucosides), confirming the requirement of Thr at the respective position for this function. Differential scanning fluorimetry (DSF) of the catalytically inactive mutant Asp199Ala of MAL1 in the presence of its substrates and selected monosaccharides suggested that the substrate‐binding pocket of MAL1 has three subsites (–1, +1 and +2) and that binding is strongest at the –1 subsite. The DSF assay results were in good accordance with affinity (K m) and inhibition (K i) data of the enzyme for tested substrates, indicating the power of the method to predict substrate binding. Deletion of either the maltase (MAL1) or α‐glucoside permease (MAL2) gene in Op abolished the growth of yeast on MAL1 substrates, confirming the requirement of both proteins for usage of these sugars. © 2016 The Authors. Yeast published by John Wiley & Sons, Ltd. PMID:26919272

  6. Three Dimensional Sector Design with Optimal Number of Sectors

    NASA Technical Reports Server (NTRS)

    Xue, Min

    2010-01-01

    In the national airspace system, sectors get overloaded due to high traffic demand and inefficient airspace designs. Overloads can be eliminated in some cases by redesigning sector boundaries. This paper extends the Voronoi-based sector design method by automatically selecting the number of sectors, allowing three-dimensional partitions, and enforcing traffic pattern conformance. The method was used to design sectors at Fort-Worth and Indianapolis centers for current traffic scenarios. Results show that new designs can eliminate overloaded sectors, although not in all cases, reduce the number of necessary sectors, and conform to major traffic patterns. Overall, the new methodology produces enhanced and efficient sector designs.

  7. Buildings Sector Analysis

    SciTech Connect

    Hostick, Donna J.; Nicholls, Andrew K.; McDonald, Sean C.; Hollomon, Jonathan B.

    2005-08-01

    A joint NREL, ORNL, and PNNL team conducted market analysis to help inform DOE/EERE's Weatherization and Intergovernmental Program planning and management decisions. This chapter presents the results of the market analysis for the Buildings sector.

  8. Construction Sector (NAICS 23)

    EPA Pesticide Factsheets

    Find environmental regulatory information for the construction sector, including the construction of buildings or engineering projects. This includes RCRA information for hazardous waste, refrigeration compliance, asbestos, effluent guidelines & lead laws

  9. Hybrid (laparoscopy + stent) treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS))

    PubMed Central

    Michalik, Maciej; Lech, Paweł; Majda, Kaja; Gutowski, Piotr

    2016-01-01

    Introduction Celiac trunk (CT) compression syndrome caused by the median arcuate ligament (MAL) is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT – the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. Aim To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Material and methods Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. Results In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. Conclusions The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis. PMID:28194242

  10. Generation of deletions in pneumococcal mal genes cloned in Bacillus subtilis.

    PubMed Central

    Lopez, P; Espinosa, M; Greenberg, B; Lacks, S A

    1984-01-01

    The pneumococcal recombinant plasmid pLS70, which contains two strong promoters for transcription of the malM and malX genes, is unstable when transferred to Bacillus subtilis, and it gives rise to deleted derivatives. Analysis of proteins produced by the deleted plasmids and restriction mapping of 29 different deletions showed that stabilization in B. subtilis was accompanied by deletions affecting both promoters. Plasmids containing even a single strong promoter were at a selective disadvantage. Nucleotide sequences surrounding the deletions in 10 plasmids were determined. Six different deletions occurred between directly repeated sequences of 3-13 base pairs in length, presumably by a recombination mechanism involving short homologies. Four deletions occurred between sites not contained within repeated sequences. A weak but significant similarity of an 11-base sequence was found surrounding these deletions and the corresponding points of junction in the progenitor plasmids. It is suggested that this sequence may be the recognition site for a topoisomerase-like enzyme that can produce deletions. Images PMID:6089185

  11. Assessment of Environmental Enteropathy in the MAL-ED Cohort Study: Theoretical and Analytic Framework

    PubMed Central

    Kosek, Margaret; Guerrant, Richard L.; Kang, Gagandeep; Bhutta, Zulfiqar; Yori, Pablo Peñataro; Gratz, Jean; Gottlieb, Michael; Lang, Dennis; Lee, Gwenyth; Haque, Rashidul; Mason, Carl J.; Ahmed, Tahmeed; Lima, Aldo; Petri, William A.; Houpt, Eric; Olortegui, Maribel Paredes; Seidman, Jessica C.; Mduma, Estomih; Samie, Amidou; Babji, Sudhir

    2014-01-01

    Individuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing world. PMID:25305293

  12. Bhaktapur, Nepal: the MAL-ED birth cohort study in Nepal.

    PubMed

    Shrestha, Prakash Sunder; Shrestha, Sanjaya Kumar; Bodhidatta, Ladaporn; Strand, Tor; Shrestha, Binob; Shrestha, Rita; Chandyo, Ram Krishna; Ulak, Manjeswori; Mason, Carl J

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study site in Nepal is located in the Bhaktapur municipality, 15 km east of Kathmandu, the capital city of Nepal. Bhaktapur, an ancient city famous for its traditional temples and buildings, is included on UNESCO's World Heritage List and is a major tourist attraction in Nepal. Nepal is a land-locked country located in South Asia between China and India with an area of 147 181 km(2), ranging from sea-level plains to Mount Everest, the world's highest peak. The total population as of the 2011 census was 26.6 million, with an average annual population growth rate of 1.4. Nepal is one of the world's least developed countries and is ranked 157 of 186 in the 2013 Human Development Report; one-third of the Nepali population lives below the poverty line. The current under-5 mortality rate is 54 per 1000 live births, the infant mortality rate is 46 per 1000 live births, and the neonatal mortality rate is 33 per 1000 live births. Vaccine coverage for all Expanded Program on Immunization vaccines is >80%. Among children, the most common diseases contributing to significant morbidity and mortality are acute respiratory infection and dehydration from severe diarrhea. In this article, we report on the geographic, demographic, and socioeconomic features of the Bhaktapur MAL-ED site and describe the data that informed our cohort recruitment strategy.

  13. Modeling environmental influences on child growth in the MAL-ED cohort study: opportunities and challenges.

    PubMed

    Richard, Stephanie A; McCormick, Benjamin J J; Miller, Mark A; Caulfield, Laura E; Checkley, William

    2014-11-01

    Although genetics, maternal undernutrition and low birth weight status certainly play a role in child growth, dietary insufficiency and infectious diseases are key risk factors for linear growth faltering during early childhood. A primary goal of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is to identify specific risk factors associated with growth faltering during the first 2 years of life; however, growth in early childhood is challenging to characterize because growth may be inherently nonlinear with age. In this manuscript, we describe some methods for analyzing longitudinal growth to evaluate both short- and long-term associations between risk factors and growth trajectories over the first 2 years of life across 8 resource-limited settings using harmonized protocols. We expect there will be enough variability within and between sites in the prevalence of risk factors and burden of linear growth faltering to allow us to distinguish some of the key pathways to linear growth faltering in the MAL-ED study.

  14. Assessment of environmental enteropathy in the MAL-ED cohort study: theoretical and analytic framework.

    PubMed

    Kosek, Margaret; Guerrant, Richard L; Kang, Gagandeep; Bhutta, Zulfiqar; Yori, Pablo Peñataro; Gratz, Jean; Gottlieb, Michael; Lang, Dennis; Lee, Gwenyth; Haque, Rashidul; Mason, Carl J; Ahmed, Tahmeed; Lima, Aldo; Petri, William A; Houpt, Eric; Olortegui, Maribel Paredes; Seidman, Jessica C; Mduma, Estomih; Samie, Amidou; Babji, Sudhir

    2014-11-01

    Individuals in the developing world live in conditions of intense exposure to enteric pathogens due to suboptimal water and sanitation. These environmental conditions lead to alterations in intestinal structure, function, and local and systemic immune activation that are collectively referred to as environmental enteropathy (EE). This condition, although poorly defined, is likely to be exacerbated by undernutrition as well as being responsible for permanent growth deficits acquired in early childhood, vaccine failure, and loss of human potential. This article addresses the underlying theoretical and analytical frameworks informing the methodology proposed by the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study to define and quantify the burden of disease caused by EE within a multisite cohort. Additionally, we will discuss efforts to improve, standardize, and harmonize laboratory practices within the MAL-ED Network. These efforts will address current limitations in the understanding of EE and its burden on children in the developing world.

  15. Methods of analysis of enteropathogen infection in the MAL-ED Cohort Study.

    PubMed

    Platts-Mills, James A; McCormick, Benjamin J J; Kosek, Margaret; Pan, William K; Checkley, William; Houpt, Eric R

    2014-11-01

    Studies of diarrheal etiology in low- and middle-income countries have typically focused on children presenting with severe symptoms to health centers and thus are best equipped to describe the pathogens capable of leading to severe diarrheal disease. The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study was designed to evaluate, via intensive community surveillance, the hypothesis that repeated exposure to enteropathogens has a detrimental effect on growth, vaccine response, and cognitive development, which are the primary outcome measures for this study. In the setting of multiple outcomes of interest, a longitudinal cohort design was chosen. Because many or even the majority of enteric infections are asymptomatic, the collection of asymptomatic surveillance stools was a critical element. However, capturing diarrheal stools additionally allowed for the determination of the principle causes of diarrhea at the community level as well as for a comparison between those enteropathogens associated with diarrhea and those that are associated with poor growth, diminished vaccine response, and impaired cognitive development. Here, we discuss the analytical methods proposed for the MAL-ED study to determine the principal causes of diarrhea at the community level and describe the complex interplay between recurrent exposure to enteropathogens and these critical long-term outcomes.

  16. Attachment of MAL32-encoded maltase on the outside of yeast cells improves maltotriose utilization.

    PubMed

    Dietvorst, J; Blieck, L; Brandt, R; Van Dijck, P; Steensma, H Y

    2007-01-01

    The fermentation of maltotriose, the second most abundant fermentable sugar in wort, is often incomplete during high-gravity brewing. Poor maltotriose consumption is due to environmental stress conditions during high-gravity fermentation and especially to a low uptake of this sugar by some industrial strains. In this study we investigated whether the use of strains with an alpha-glucosidase attached to the outside of the cell might be a possible way to reduce residual maltotriose. To this end, the N-terminal leader sequence of Kre1 and the carboxy-terminal anchoring domain of either Cwp2 or Flo1 were used to target maltase encoded by MAL32 to the cell surface. We showed that Mal32 displayed on the cell surface of Saccharomyces cerevisiae laboratory strains was capable of hydrolysis of alpha-1,4-linkages, and that it increased the ability of a strain lacking a functional maltose permease to grow on maltotriose. Moreover, the enzyme was also expressed and found to be active in an industrial strain. These data show that expressing a suitable maltase on the cell surface might provide a means of modifying yeast for more complete maltotriose utilization in brewing and other fermentation applications.

  17. Sector-scanning echocardiography

    NASA Technical Reports Server (NTRS)

    Henry, W. L.; Griffith, J. M.

    1975-01-01

    The mechanical sector scanner is described in detail, and its clinical application is discussed. Cross sectional images of the heart are obtained in real time using this system. The sector scanner has three major components: (a) hand held scanner, (b) video display, and (c) video recorder. The system provides diagnostic information in a wide spectrum of cardiac diseases, and it quantitates the severity of mitral stenosis by measurement of the mitral valve orifice area in diagnosing infants, children and adults with cyanotic congenital heart disease.

  18. Distinct mechanism of activation of two transcription factors, AmyR and MalR, involved in amylolytic enzyme production in Aspergillus oryzae.

    PubMed

    Suzuki, Kuta; Tanaka, Mizuki; Konno, Yui; Ichikawa, Takanori; Ichinose, Sakurako; Hasegawa-Shiro, Sachiko; Shintani, Takahiro; Gomi, Katsuya

    2015-02-01

    The production of amylolytic enzymes in Aspergillus oryzae is induced in the presence of starch or maltose, and two Zn2Cys6-type transcription factors, AmyR and MalR, are involved in this regulation. AmyR directly regulates the expression of amylase genes, and MalR controls the expression of maltose-utilizing (MAL) cluster genes. Deletion of malR gene resulted in poor growth on starch medium and reduction in α-amylase production level. To elucidate the activation mechanisms of these two transcription factors in amylase production, the expression profiles of amylases and MAL cluster genes under carbon catabolite derepression condition and subcellular localization of these transcription factors fused with a green fluorescent protein (GFP) were examined. Glucose, maltose, and isomaltose induced the expression of amylase genes, and GFP-AmyR was translocated from the cytoplasm to nucleus after the addition of these sugars. Rapid induction of amylase gene expression and nuclear localization of GFP-AmyR by isomaltose suggested that this sugar was the strongest inducer for AmyR activation. In contrast, GFP-MalR was constitutively localized in the nucleus and the expression of MAL cluster genes was induced by maltose, but not by glucose or isomaltose. In the presence of maltose, the expression of amylase genes was preceded by MAL cluster gene expression. Furthermore, deletion of the malR gene resulted in a significant decrease in the α-amylase activity induced by maltose, but had apparently no effect on the expression of α-amylase genes in the presence of isomaltose. These results suggested that activation of AmyR and MalR is regulated in a different manner, and the preceding activation of MalR is essential for the utilization of maltose as an inducer for AmyR activation.

  19. [Metabolism and elimination of ethosuximide in neonates whose mothers had petit mal].

    PubMed

    Tejerizo López, L C; de Santiago Obeso, J; Henríquez Esquiroz, J M; Pérez González, M C; Jorge Mendoza, J M

    1987-11-01

    In thirteen newborn infants of mothers affected with "petit mal" and treated with ethosuximide, submitted to artificial feeding with powdered milk, it was found that transplacental elimination of the drug occurred. Authors recorded daily serum concentration of ethosuximide and found that average life before it was totally eliminated was 80.62 +/- 7.24 hours. At the moment of birth serum concentration of mothers, and their newborn infants are similar due to transplacental by-pass. Through a lineal regression coefficient they find a relation between serum concentration in newborn infants and time passed from the moment of birth. This coefficient was negative and thus signified facility of the newborn to eliminate the drug. This result allows us to treat the mother adequately during anti-natal period with adequate dose to avoid subsequent epileptic attacks without producing toxicity in the newborn child.

  20. Infant feeding practices, dietary adequacy, and micronutrient status measures in the MAL-ED study.

    PubMed

    Caulfield, Laura E; Bose, Anuradha; Chandyo, Ram Krishna; Nesamvuni, Cebisa; de Moraes, Milena Lima; Turab, Ali; Patil, Crystal; Mahfuz, Mustafa; Ambikapathi, Ramya; Ahmed, Tahmeed

    2014-11-01

    The overall goal of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study is to evaluate the roles of repeated enteric infection and poor dietary intakes on the development of malnutrition, poor cognitive development, and diminished immune response. The use of 8 distinct sites for data collection from Latin America, sub-Saharan Africa, and South Asia allow for an examination of these relationships across different environmental contexts. Key to testing study hypotheses is the collection of appropriate data to characterize the dietary intakes and nutritional status of study children from birth through 24 months of age. The focus of the current article is on the collection of data to describe the nature and adequacy of infant feeding, energy and nutrient intakes, and the chosen indicators to capture micronutrient status in children over time.

  1. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    PubMed Central

    Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C. K.

    2014-01-01

    This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices. PMID:25165729

  2. Data extraction for complex meta-analysis (DECiMAL) guide.

    PubMed

    Pedder, Hugo; Sarri, Grammati; Keeney, Edna; Nunes, Vanessa; Dias, Sofia

    2016-12-13

    As more complex meta-analytical techniques such as network and multivariate meta-analyses become increasingly common, further pressures are placed on reviewers to extract data in a systematic and consistent manner. Failing to do this appropriately wastes time, resources and jeopardises accuracy. This guide (data extraction for complex meta-analysis (DECiMAL)) suggests a number of points to consider when collecting data, primarily aimed at systematic reviewers preparing data for meta-analysis. Network meta-analysis (NMA), multiple outcomes analysis and analysis combining different types of data are considered in a manner that can be useful across a range of data collection programmes. The guide has been shown to be both easy to learn and useful in a small pilot study.

  3. Sector Study Guideline

    DTIC Science & Technology

    1990-03-01

    LIMITS . . . . . . . . 8 5.1 Market Groups . ................ 8 5.2 Market Group A and the Level of Effort (LOE) Assessment...9 5.3 Market Groups B and Level of Effort (LOE) Assessment . . . . . . . . . 10 5.4 Market Group C and the Level of Effort Assessment 11 5.5... Market Groups Al, B1, C1 versus A2, B2, C2 (LOE) 11 6.0 AVAILABILITY OF INFORMATION . . . . . . . . . . . . . 12 7.0 OVERVIEW OF THE PROPOSED SECTOR

  4. Comparative in vivo study of precursors of PpIX (ALA and MAL) used topically in photodynamic therapy

    NASA Astrophysics Data System (ADS)

    Rego, Raquel F.; Inada, Natalia M.; Ferreira, Juliana; Araújo-Moreira, Fernando M.; Bagnato, Vanderlei S.

    2009-06-01

    The efficacy of Photodynamic Therapy (PDT) combined with aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) in treatment of cancer has been studied for over ten years. However, there is no established dose for the topical use of these drugs in PDT. The purpose of this study was the comparison of induced PDT response of ALAsense (5-aminolevulinic acid - ALA) and Metvix (methyl aminolevulinate - MAL). Depth of necrosis induced by PDT was analyzed in normal liver of male Wistar rats, using different light doses and topical application of both PpIX precursors - ALA and MAL. PDT was performed with a diode laser at 630 nm with different doses of light (20, 50, 100 and 200 J/cm2), and intensity of 250 mW/cm2. Depth of necrosis analysis was used to calculate the threshold dose for each drug. The results showed that MAL-PDT presented a better response than ALA-PDT, mainly due to formulation differences. Moreover, the ability of the ALA PpIX production was more efficient.

  5. Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL.

    PubMed

    Sengupta, Dola; Koblansky, Alicia; Gaines, Jennifer; Brown, Tim; West, A Phillip; Zhang, Dekai; Nishikawa, Tak; Park, Sung-Gyoo; Roop, R Martin; Ghosh, Sankar

    2010-01-15

    Gram-negative bacteria belonging to the Brucella species cause chronic infections that can result in undulant fever, arthritis, and osteomyelitis in humans. Remarkably, Brucella sp. genomes encode a protein, named TcpB, that bears significant homology with mammalian Toll/IL-1 receptor domains and whose expression causes degradation of the phosphorylated, signal competent form of the adapter MyD88-adapter-like (MAL). This effect of TcpB is mediated through its box 1 region and has no effect on other TLR adapter proteins such as MyD88 or TIR-domain containing adapter protein-inducing IFNbeta. TcpB also does not affect a mutant, signal-incompetent form of MAL that cannot be phosphorylated. Interestingly, the presence of TcpB leads to enhanced polyubiquitination of MAL, which is likely responsible for its accelerated degradation. A Brucella abortus mutant lacking TcpB fails to reduce levels of MAL in infected macrophages. Therefore, TcpB represents a unique pathogen-derived molecule that suppresses host innate-immune responses by specifically targeting an individual adapter molecule in the TLR signaling pathway for degradation.

  6. Chiral Dark Sector

    NASA Astrophysics Data System (ADS)

    Co, Raymond T.; Harigaya, Keisuke; Nomura, Yasunori

    2017-03-01

    We present a simple and natural dark sector model in which dark matter particles arise as composite states of hidden strong dynamics and their stability is ensured by accidental symmetries. The model has only a few free parameters. In particular, the gauge symmetry of the model forbids the masses of dark quarks, and the confinement scale of the dynamics provides the unique mass scale of the model. The gauge group contains an Abelian symmetry U (1 )D , which couples the dark and standard model sectors through kinetic mixing. This model, despite its simple structure, has rich and distinctive phenomenology. In the case where the dark pion becomes massive due to U (1 )D quantum corrections, direct and indirect detection experiments can probe thermal relic dark matter which is generically a mixture of the dark pion and the dark baryon, and the Large Hadron Collider can discover the U (1 )D gauge boson. Alternatively, if the dark pion stays light due to a specific U (1 )D charge assignment of the dark quarks, then the dark pion constitutes dark radiation. The signal of this radiation is highly correlated with that of dark baryons in dark matter direct detection.

  7. Functional expression and molecular characterization of Culex quinquefasciatus salivary α-glucosidase (MalI).

    PubMed

    Suthangkornkul, Rungarun; Sirichaiyakul, Phanthila; Sungvornyothin, Sungsit; Thepouyporn, Apanchanid; Svasti, Jisnuson; Arthan, Dumrongkiet

    2015-06-01

    Salivary α-glucosidases (MalI) have been much less characterized when compared with midgut α-glucosidases, which have been studied in depth. Few studies have been reported on the partial characterization of MalI, but no clear function has been ascribed. The aim of this study is to purify and characterize the recombinant Culex quinquefasciatus (CQ) α-glucosidase expressed in Pichia pastoris. The cDNA encoding mature Cx. quinquefasciatus α-glucosidase gene with polyhistidine tag (rCQMalIHis) was successfully cloned into the expression vector, pPICZαB, designated as pPICZαB/CQMalIHis. The activity of recombinant rCQMalIHis expressed in P. pastoris could be detected at 3.75U/ml, under optimal culture conditions. The purified rCQMalIHis showed a single band of molecular weight of approximately 92kDa on SDS-PAGE. After Endoglycosidase H digestion, a single band at 69kDa was found on SDS-PAGE analysis, suggesting that rCQMalIHis is a glycoprotein. Additionally, tryptic digestion and LC-MALDI MS/MS analysis suggested that the 69kDa band corresponds to the Cx. quinquefasciatus α-glucosidase. Thus, rCQMalIHis is a glycoprotein. The rCQMalIHis exhibited optimum pH and temperature at 5.5 and 35°C, respectively. The catalytic efficiency (kcat/Km) of the purified rCQMalIHis for maltotriose is higher than those for sucrose, maltotetraose, maltose and p-nitrophenyl-α-glucoside, indicating that the enzyme prefers maltotriose. Additionally, the rCQMalIHis is significantly inhibited by d-gluconic acid δ-lactone, but not by Mg(2+), Ca(2+) and EDTA. The rCQMalIHis is strongly inhibited by acarbose with IC50 67.8±5.6nM, but weakly inhibited by glucose with IC50 115.9±7.3mM.

  8. The sun's magnetic sector structure

    NASA Technical Reports Server (NTRS)

    Svalgaard, L.; Wilcox, J. M.; Scherrer, P. H.; Howard, R.

    1975-01-01

    The synoptic appearance of solar magnetic sectors is studied using 454 sector boundaries observed at earth during 1959-1973. The sectors are clearly visible in the photospheric magnetic field. Sector boundaries can be clearly identified as north-south running demarcation lines between regions of persistent magnetic polarity imbalances. These regions extend up to about 35 deg of latitude on both sides of the equator. They generally do not extend into the polar caps. The polar cap boundary can be identified as an east-west demarcation line marking the poleward limit of the sectors. The typical flux imbalance for a magnetic sector is about 4 x 10 to the 21st power Maxwells.

  9. Energy Sector Market Analysis

    SciTech Connect

    Arent, D.; Benioff, R.; Mosey, G.; Bird, L.; Brown, J.; Brown, E.; Vimmerstedt, L.; Aabakken, J.; Parks, K.; Lapsa, M.; Davis, S.; Olszewski, M.; Cox, D.; McElhaney, K.; Hadley, S.; Hostick, D.; Nicholls, A.; McDonald, S.; Holloman, B.

    2006-10-01

    This paper presents the results of energy market analysis sponsored by the Department of Energy's (DOE) Weatherization and International Program (WIP) within the Office of Energy Efficiency and Renewable Energy (EERE). The analysis was conducted by a team of DOE laboratory experts from the National Renewable Energy Laboratory (NREL), Oak Ridge National Laboratory (ORNL), and Pacific Northwest National Laboratory (PNNL), with additional input from Lawrence Berkeley National Laboratory (LBNL). The analysis was structured to identify those markets and niches where government can create the biggest impact by informing management decisions in the private and public sectors. The analysis identifies those markets and niches where opportunities exist for increasing energy efficiency and renewable energy use.

  10. Exploring Oman's Energy Sector

    NASA Astrophysics Data System (ADS)

    Al-Saqlawi, Juman; Madani, Kaveh; Mac Dowell, Niall

    2016-04-01

    Located in a region where over 40% of the world's oil and gas reserves lie and in a trend similar to that of its neighbors, Oman's economy has been reliant on crude oil export since the 1970's. Being aware of the dangers of this reliance along with the discovery of Natural Gas since the 1980s, the Omani government's policy of diversifying its economy has shifted its reliance on Oil to another fossil fuel, namely Natural Gas. Given that energy is the lifeline of Oman's economy, effective and efficient forward planning and policy development is essential for the country's current and future economic development. This presentation explores the current status of the energy sector in Oman from home production and import to eventual final uses. The presentation highlights the major issues with Oman's current energy policies and suggests various strategies that could be adopted by Oman for a more efficient and sustainable future.

  11. Maleimide Functionalized Poly(ε-caprolactone)-b-poly(ethylene glycol) (PCL-PEG-MAL): Synthesis, Nanoparticle Formation, and Thiol Conjugation

    PubMed Central

    Ji, Shengxiang; Zhu, Zhengxi; Hoye, Thomas R.; Macosko, Christopher W.

    2010-01-01

    Summary Carboxylic acid terminated poly(ε-caprolactone)s (PCL-COOHs) with narrow polydispersity were synthesized and coupled with poly(ethylene glycol) (HO-PEG-OH) to afford PCL-PEG-OH copolymers. The hydroxyl groups in the PCL-PEG-OHs were then converted to maleimide groups to afford maleimide terminated PCL-PEG-MALs that contained 70–90% maleimide functionality. Nanoparticles with maleimide functionality on their surfaces were prepared by impingement mixing. Particle sizes and size distributions were determined by dynamic light scattering. Conjugation of reduced glutathione with model maleimides and two MAL-functional nanoparticles was also demonstrated. The amount of accessible maleimide on the particle surface was measured using Ellman’s reagent to range between ~51–67%. PMID:21731402

  12. Uncertainty bounds using sector theory

    NASA Technical Reports Server (NTRS)

    Waszak, Martin R.; Schmidt, David K.

    1989-01-01

    An approach based on sector-stability theory can furnish a description of the uncertainty associated with the frequency response of a model, given sector-bounds on the individual parameters of the model. The application of the sector-based approach to the formulation of useful uncertainty descriptions for linear, time-invariant multivariable systems is presently explored, and the approach is applied to two generic forms of parameter uncertainty in order to investigate its advantages and limitations. The results obtained show that sector-uncertainty bounds can be used to evaluate the impact of parameter uncertainties on the frequency response of the design model.

  13. Determinants of road traffic injury among adult motorcyclists in Malé, Maldives.

    PubMed

    Waseela, Mariyam; Laosee, Orapin

    2015-04-01

    This study investigates the incidence of nonfatal road traffic injuries (RTIs) in Malé, the capital city of the Maldives, and identifies risk factors associated with RTIs. A cross-sectional descriptive study was conducted among young adult motorcyclists in 3 public areas. A total of 350 self-administered questionnaires were distributed to the motorcycle riders who visited the study areas between December 2012 and January 2013. The incidence of RTIs for the previous 12 months was 39.8% among the 294 respondents who returned a completed questionnaire. About half (49.6%) of those were caused by the riders. The majority of riders were male (96.6%). None of the motorcycle riders wore a helmet. RTIs had a significant association with sex, age, and attitude. Young riders were 1.6 times more likely to be involved in an RTI (adjusted odds ratio [AOR] = 1.67; 95% confidence interval [CI] = 0.94-2.95). Having a negative attitude about road safety was a risk factor of RTIs (AOR = 1.84; 95% CI = 1.11-3.03). Based on the results of the present study, it is important to promote safe riding attitudes in young riders.

  14. Disease surveillance methods used in the 8-site MAL-ED cohort study.

    PubMed

    Richard, Stephanie A; Barrett, Leah J; Guerrant, Richard L; Checkley, William; Miller, Mark A

    2014-11-01

    Describing the early life associations between infectious disease episodes and growth, cognitive development, and vaccine response in the first 2 years of life is one of the primary goals of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study. To collect high-resolution data during a critical early period of development, field staff visit each study participant at their house twice weekly from birth to 2 years of age to collect daily reported illness and treatment data from caregivers. Detailed infectious disease histories will not only allow us to relate the overall burden of infectious disease with the primary outcomes of the study, but will also allow us to describe the ages at which infectious diseases have the greatest effect on child health. In addition, twice-weekly visits allow for sample collection when diarrhea episodes are identified. This article describes the methods used to collect illness and treatment history data and discusses the a priori definitions of diarrhea and acute lower respiratory illness episodes.

  15. Introduction of the carbohydrate-activated promoter P(malK) for recombinant protein production.

    PubMed

    Boström, M; Larsson, G

    2002-07-01

    A production protocol for the use of the malK promoter was established. The protocol includes two phases: an initial fed-batch phase on glucose to reach a high cell density and a fed-batch phase on maltose for production of the desired recombinant protein. It is suggested that this cultivation scheme could be used for all promoters that are catabolite repressed by glucose and where growth and production need to be separated. The specific feature of this system is shown by its ability to control the rate of synthesis of the product protein, ss-galactosidase. In the production phase with a constant feed or an exponential feeding of 0.1 h(-1) it took 4 h longer to reach the maximum specific production rate than with the higher dilution rates of 0.25 h(-1) and 0.4 h(-1), respectively. In the above experiments a dilution rate of 0.3 h(-1) in the growth phase was used. The volumetric production of this system could furthermore be extended to 40 h. All protocol procedures so far tested resulted in the same maximum production rate, but reached in different lengths of time. It is argued that this system is particularly well suited for the production of proteins that have a complex structure and/or need to be produced in a soluble form or to be exported to the periplasm.

  16. Clinical features of mal de debarquement: adaptation and habituation to sea conditions.

    PubMed

    Gordon, C R; Spitzer, O; Doweck, I; Melamed, Y; Shupak, A

    1995-01-01

    A survey conducted among 116 crew members of seagoing vessels confirmed that mal de debarquement (M-D) is a transient feeling of swinging, swaying, unsteadiness, and disequilibrium. None of the subjects requested medical attention, although there were isolated cases in which a strong sensation of swinging and unsteadiness caused transient postural instability and impaired the ability to drive. In most cases, the sensation of M-D appeared immediately on disembarking and generally lasted a few hours. In addition, subjects usually described bouts or attacks of M-D associated with changes in body posture, head position, or with closing of the eyes. M-D was reported by 72% of our subjects. Sixty-six percent of subjects reported a high incidence following their first voyages. A significant positive correlation was found between M-D and seasickness susceptibility. The nature of M-D may be explained within the framework of multisensorimotor adaptation and habituation to a new or abnormal motion environment. It is suggested that M-D represents a dynamic, multisensorimotor form of CNS adaptive plasticity.

  17. Santa Clara de Nanay: the MAL-ED cohort in Peru.

    PubMed

    Yori, Pablo Peñataro; Lee, Gwenyth; Olórtegui, Maribel Paredes; Chávez, César Banda; Flores, Julian Torres; Vasquez, Angel Orbe; Burga, Rosa; Pinedo, Silvia Rengifo; Asayag, César Ramal; Black, Robert E; Caulfield, Laura E; Kosek, Margaret

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study communities in Peru are located in Loreto province, in a rural area 15 km from the city of Iquitos. This riverine population of approximately 5000 individuals is fairly representative of Loreto. The province lags behind the rest of the country in access to water and sanitation, per capita income, and key health indicators including infant mortality (43.0 vs 16.0 per 1000 nationwide) and under-5 mortality (60.6 vs 21.0 per 1000). Total fertility rates are higher than elsewhere in the country (4.3 vs 2.6). Nationwide, the prevalence of human immunodeficiency virus is estimated at 0.45%, the prevalence of tuberculosis is 117 per 100 000, and the incidence of malaria is 258 per 100 000. Stunting in this community is high, whereas acute undernutrition is relatively uncommon. The population suffers from high rates of diarrheal disease. Prevalent enteric pathogens include Ascaris, Giardia, enterotoxigenic Escherichia coli, Shigella, and Campylobacter.

  18. Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.

    PubMed Central

    Coulter, D. A.; Huguenard, J. R.; Prince, D. A.

    1990-01-01

    1. Succinimide derivatives can be either convulsant (tetramethylsuccinimide (TMS)), or anticonvulsant (ethosuximide (ES); alpha-methyl-alpha-phenylsuccinimide (MPS)). ES, an anticonvulsant succinimide, has previously been shown to block calcium currents of thalamic neurones, while the convulsant succinimide TMS blocks gamma-aminobutyric acid (GABA) responses in a similar fashion to the convulsant pentylenetetrazol (PTZ). 2. Using voltage-clamp techniques, we analysed the effects of the anticonvulsant succinimides ES and MPS and the convulsants TMS and PTZ on calcium currents of acutely isolated thalamic relay neurones of the rat. 3. MPS and ES reduced low-threshold calcium current (LTCC) in a voltage-dependent manner, without affecting steady-state inactivation. MPS was less potent than ES (IC50 of 1100 vs 200 microM) but greater in efficacy (100% maximal reduction vs 40% for ES). 4. PTZ had no effect on calcium currents, and TMS only reduced LTCC at very high concentrations, and did not occlude MPS effects when applied concurrently. 5. These results, which demonstrate that anticonvulsant, but not convulsant, succinimides block LTCC, provide additional support for the hypothesis that LTCC reduction is a mechanism of action of the anticonvulsant succinimides related to their effects in petit mal epilepsy. PMID:2169941

  19. Investigation of the physical properties of the tetragonal CeMAl4Si2 (M = Rh, Ir, Pt) compounds

    DOE PAGES

    Ghimire, N. J.; Ronning, F.; Williams, D. J.; ...

    2014-12-15

    The synthesis, crystal structure and physical properties studied by means of x-ray diffraction, magnetic, thermal and transport measurements of CeMAl4Si2 (M = Rh, Ir, Pt) are reported, along with the electronic structure calculations for LaMAl4Si2 (M = Rh, Ir, Pt). These materials adopt a tetragonal crystal structure (space group P4/mmm) comprised of BaAl4 blocks, separated by MAl2 units, stacked along the c-axis. Both CeRhAl4Si2 and CeIrAl4Si2 order antiferromagnetically below TN1 = 14 and 16 K, respectively, and undergo a second antiferromagnetic transitition at lower temperature (TN2 = 9 and 14 K, respectively). CePtAl4Si2 orders ferromagnetically below TC = 3 Kmore » with an ordered moment of μsat = 0.8 μB for a magnetic field applied perpendicular to the c-axis. Electronic structure calculations reveal quasi-2D character of the Fermi surface.« less

  20. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy.

    PubMed

    Kinaciyan, T; Nagl, B; Faustmann, S; Kopp, S; Wolkersdorfer, M; Bohle, B

    2016-02-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 μg induced oral allergy syndromes in 26.4%, 3.2 μg in 15.3%, 6.3 μg in 27.8%, 12.5 μg in 8.3%, 25 μg in 11.1%, and 50 μg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 μg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy.

  1. Pt-Mal-LHRH, a Newly Synthesized Compound Attenuating Breast Cancer Tumor Growth and Metastasis by Targeting Overexpression of the LHRH Receptor.

    PubMed

    Calderon, Lindsay E; Keeling, Jonathan K; Rollins, Joseph; Black, Carrie A; Collins, Kendall; Arnold, Nova; Vance, Diane E; Ndinguri, Margaret W

    2017-02-15

    A new targeting chemotherapeutic agent, Pt-Mal-LHRH, was synthesized by linking activated cisplatin to luteinizing hormone releasing hormone (LHRH). The compound's efficacy and selectivity toward 4T1 breast cancer cells were evaluated. Carboplatin was selected as the comparative platinum complex, since the Pt-Mal-LHRH malonate linker chelates platinum in a similar manner to carboplatin. Breast cancer and normal cell viability were analyzed by an MTT assay comparing Pt-Mal-LHRH with carboplatin. Cells were also treated with either Pt-Mal-LHRH or carboplatin to evaluate platinum uptake by ICP-MS and cell migration using an in vitro scratch-migration assay. Tumor volume and metastasis were evaluated using an in vivo 4T1 mouse tumor model. Mice were administered Pt-Mal-LHRH (carboplatin molar equivalent dosage) through ip injection and compared to those treated with carboplatin (5 (mg/kg)/week), no treatment, and LHRH plus carboplatin (unbound) controls. An MTT assay showed a reduction in cell viability (p < 0.01) in 4T1 and MDA-MB-231 breast cancer cells treated with Pt-Mal-LHRH compared to carboplatin. Pt-Mal-LHRH was confirmed to be cytotoxic by flow cytometry using a propidium iodide stain. Pt-Mal-LHRH displayed a 20-fold increase in 4T1 cellular uptake compared to carboplatin. There was a decrease (p < 0.0001) in 4T1 cell viability compared to 3T3 normal fibroblast cells. Treatment with Pt-Mal-LHRH also resulted in a significant decrease in cell-migration compared to carboplatin. In vivo testing found a significant reduction in tumor volume (p < 0.05) and metastatic tumor colonization in the lungs with Pt-Mal-LHRH compared to carboplatin. There was a slight decrease in lung weight and no difference in liver weight between treatment groups. Together, our data indicate that Pt-Mal-LHRH is a more potent and selective chemotherapeutic agent than untargeted carboplatin.

  2. Effect of component mal-rotation on knee loading in total knee arthroplasty using multi-body dynamics modeling under a simulated walking gait.

    PubMed

    Chen, Zhenxian; Wang, Ling; Liu, Yaxiong; He, Jiankang; Lian, Qin; Li, Dichen; Jin, Zhongmin

    2015-09-01

    Mal-rotation of the components in total knee arthorplasty (TKA) is a major cause of postoperative complications, with an increased propensity for implant loosening or wear leading to revision. A musculoskeletal multi-body dynamics model was used to perform a parametric study of the effects of the rotational mal-alignments in TKA on the knee loading under a simulated walking gait. The knee contact forces were found to be more sensitive to variations in the varus-valgus rotation of both the tibial and the femoral components and the internal-external rotation of the femoral component in TKA. The varus-valgus mal-rotation of the tibial or femoral component and the internal-external mal-rotation of the femoral component with a 5° variation were found to affect the peak medial contact force by 17.8-53.1%, the peak lateral contact force by 35.0-88.4% and the peak total contact force by 5.2-18.7%. Our findings support the clinical observations that a greater than 3° internal mal-rotation of the femoral component may lead to unsatisfactory pain levels and a greater than 3° varus mal-rotation of the tibial component may lead to medial bone collapse. These findings determined the quantitative effects of the mal-rotation of the components in TKA on the contact load. The effect of such mal-rotation of the components of TKA on the kinematics would be further addressed in future studies.

  3. Partnership in Sector Wide Approaches

    ERIC Educational Resources Information Center

    Tolley, Hilary

    2011-01-01

    Within the context of bilateral support to the education sector in Tonga and the Solomon Islands, this paper will explore how the discourse of "partnership" has been interpreted and activated within the Sector wide approach (SWAp). In concentrating particularly on the relationship between the respective Ministries of Education and New…

  4. Early interruption of exclusive breastfeeding: results from the eight-country MAL-ED study.

    PubMed

    Patil, Crystal L; Turab, Ali; Ambikapathi, Ramya; Nesamvuni, Cebisa; Chandyo, Ram Krishna; Bose, Anuradha; Islam, M Munirul; Ahmed, A M Shamsir; Olortegui, Maribel Paredes; de Moraes, Milena Lima; Caulfield, Laura E

    2015-05-01

    We report the infant feeding experiences in the first month of life for 2,053 infants participating in "Malnutrition and Enteric Infections: Consequences for Child Health and Development" (MAL-ED). Eight sites (in Bangladesh, India, Nepal, Pakistan, Brazil, Peru, South Africa, Tanzania), each followed a cohort of children from birth (by day 17), collecting detailed information on infant feeding practices, diet and illness episodes. Mothers were queried twice weekly regarding health status, breastfeeding and the introduction (or no) of non-breast milk liquids and foods. Here, our goal is to describe the early infant feeding practices in the cohort and evaluate factors associated with termination of exclusive breastfeeding in the first month of life. With data from enrollment to a visit at 28-33 days of life, we characterized exclusive, predominant or partial breastfeeding (using a median of 6-9 visits per child across the sites). Only 6 of 2,053 infants were never breastfed. By one month, the prevalences of exclusive breastfeeding were < 60% in 6 of 8 sites, and of partial breastfeeding (or no) were > 20% in 6 of 8 sites. Logistic regression revealed that prelacteal feeding (given to 4-63% of infants) increased the likelihood of partial breastfeeding (Odds Ratio (OR): 1.48 (95% confidence interval (CI): 1.04, 2.10), as did the withholding of colostrum (2-16% of infants) (OR: 1.63:1.01, 2.62), and being a first-time mother (OR: 1.38:1.10, 1.75). Our results reveal diversity across these sites, but an overall trend of early transition away from exclusive breastfeeding in the first month of life. Interventions which introduce or reinforce the WHO/UNICEF Ten Steps for Successful Breastfeeding are needed in these sites to improve breastfeeding initiation, to reinforce exclusive breastfeeding and delay introduction of non-breast milk foods and/or liquids.

  5. Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome.

    PubMed

    Dai, Mingjia; Cohen, Bernard; Smouha, Eric; Cho, Catherine

    2014-01-01

    The mal de debarquement syndrome (MdDS), a continuous feeling of swaying, rocking, and/or bobbing, generally follows travel on the sea. The associated symptoms cause considerable distress. The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. Results in monkeys and humans suggested that MdDS was caused by maladaptation of the vestibulo-ocular reflex (VOR) to roll of the head during rotation. We studied 24 subjects with persistent MdDS (3 males, 21 females; 19.1 ± 33 months). Physical findings included body oscillation at 0.2 Hz, oscillating vertical nystagmus when the head was rolled from side-to-side in darkness, and unilateral rotation during the Fukuda stepping test. We posited that the maladapted rocking and the physical symptoms could be diminished or extinguished by readapting the VOR. Subjects were treated by rolling the head from side-to-side while watching a rotating full-field visual stimulus. Seventeen of the 24 subjects had a complete or substantial recovery on average for approximately 1 year. Six were initially better, but the symptoms recurred. One subject did not respond to treatment. Thus, readaptation of the VOR has led to a cure or substantial improvement in 70% of the subjects with MdDS. We conclude that the adaptive processes associated with roll-while-rotating are responsible for producing MdDS, and that the symptoms can be reduced or resolved by readapting the VOR.

  6. 50 CFR 648.87 - Sector allocation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Fixed Gear Sector, as defined in § 648.87(d)(1) or (2), joins a new sector, or fishes pursuant to the... in a sector may only fish in a particular stock area, as specified in paragraphs (b)(1)(ii)(A... that sector to fish under the provisions of the common pool or in another sector in the year...

  7. Thermal relics in hidden sectors

    SciTech Connect

    Feng, Jonathan L; Tu, Huitzu; Yu, Hai-Bo E-mail: huitzut@uci.edu

    2008-10-15

    Dark matter may be hidden, with no standard model gauge interactions. At the same time, in WIMPless models (WIMP: weakly interacting massive particles) with hidden matter masses proportional to hidden gauge couplings squared, the hidden dark matter's thermal relic density may naturally be in the right range, preserving the key quantitative virtue of WIMPs. We consider this possibility in detail. We first determine model-independent constraints on hidden sectors from big bang nucleosynthesis and the cosmic microwave background. Contrary to conventional wisdom, large hidden sectors are easily accommodated. A flavour-free version of the standard model is allowed if the hidden sector is just 30% colder than the observable sector after reheating. Alternatively, if the hidden sector contains a one-generation version of the standard model with characteristic mass scale below 1 MeV, even identical reheating temperatures are allowed. We then analyse hidden sector freeze-out in detail for a concrete model, solving the Boltzmann equation numerically and explaining the results from both observable and hidden sector points of view. We find that WIMPless dark matter does indeed obtain the correct relic density for masses in the range keV{approx}

  8. Temperature compensation for miniaturized magnetic sector

    NASA Technical Reports Server (NTRS)

    Sinha, Mahadeva P. (Inventor)

    2002-01-01

    Temperature compensation for a magnetic sector used in mass spectrometry. A high temperature dependant magnetic sector is used. This magnetic sector is compensated by a magnetic shunt that has opposite temperature characteristics to those of the magnet.

  9. Textile Manufacturing Sector (NAICS 313)

    EPA Pesticide Factsheets

    Find environmental regulatory and compliance information for the textile and leather manufacturing sector, including NESHAPs for leather tanning and fabric printing, and small business guidance for RCRA hazardous waste requirements.

  10. Chemical Manufacturing Sector (NAICS 325)

    EPA Pesticide Factsheets

    find EPA regulatory information for the chemical manufacturing sector, including NESHAPs, the SNAP program for ozone depleting substances,effluent guidelines, and new and existing chemicals testing requirements under TSCA.

  11. Wood and Paper Manufacturing Sectors

    EPA Pesticide Factsheets

    Find EPA regulatory information for the wood product and paper manufacturing sectors, including paper, pulp and lumber. Information includes NESHAPs and effluent guidelines for pulp and paper rulemaking, and compliance guidelines

  12. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    PubMed Central

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  13. Tuberculose ostéoarticulaire (mal de Pott exclu): à propos de 120 cas à Abidjan

    PubMed Central

    Gbané-Koné, Mariam; Koné, Samba; Ouali, Boubacar; Djaha, Kouassi Jean -Mermoz; Akoli, Ekoya Ondzala; Nseng, Ingrid Nseng; Eti, Edmond; Daboiko, Jean Claude; Touré, Stanislas André; Kouakou, N'zué Marcel

    2015-01-01

    Introduction La tuberculose ostéoarticulaire (TOA) représente 2 à 5% de l'ensemble des tuberculoses. Elle demeure d'actualité surtout dans les pays à forte endémicité tuberculeuse. L'objectif était de déterminer la prévalence, les aspects topographiques, radiologiques de la TOA en milieu hospitalier ivoirien. Méthodes Les auteurs rapportent une expérience de 11 ans, à travers une étude rétrospective de 120 dossiers de patients atteints de la tuberculose ostéoarticulaire (le mal de Pott est exclu de cette étude). N'ont pas été inclus dans l’étude les dossiers ne comportant pas d'imagerie. Résultats L'atteinte extra vertébrale représentait 09,2% de la tuberculose ostéoarticulaire. Il s'agissait de 54 hommes et 66 femmes, l’âge moyen était de 43,13 ans. On notait 123 cas d'ostéoarthrites, et 8 cas d'ostéites des os plats. L'atteinte des membres inférieurs prédominait dans 91,87% des cas. La hanche était la première localisation (45,04%), suivie du genou (25,19%). Les atteintes étaient multifocales dans 20% des cas. L'atteinte osseuse était associée à une tuberculose pulmonaire dans 05,83% des cas. Des localisations inhabituelles ont été rapportées: poignet (n = 2), branches ischiopubiennes (n = 4), atteinte sternoclaviculaire (n = 4), médiopieds (n = 2). Les lésions radiologiques étaient avancées (stades III et IV) dans 55,73% des cas. A la TDM, la prévalence des abcès était de 77%. Un geste chirurgical a été réalisé sur 16 articulations (2 épaules, 13 genoux, une cheville). Conclusion La TOA des membres est peu fréquente contrairement à l'atteinte vertébrale. La hanche est la principale localisation. Le retard au diagnostic explique l’étendue des lésions anatomoradiologiques. PMID:26587129

  14. An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation

    PubMed Central

    Matsuo, Yuzy; Maurer, Sebastian P.; Yukawa, Masashi; Zakian, Silva; Singleton, Martin R.; Surrey, Thomas

    2016-01-01

    ABSTRACT Dynamic microtubule plus-ends interact with various intracellular target regions such as the cell cortex and the kinetochore. Two conserved families of microtubule plus-end-tracking proteins, the XMAP215, ch-TOG or CKAP5 family and the end-binding 1 (EB1, also known as MAPRE1) family, play pivotal roles in regulating microtubule dynamics. Here, we study the functional interplay between fission yeast Dis1, a member of the XMAP215/TOG family, and Mal3, an EB1 protein. Using an in vitro microscopy assay, we find that purified Dis1 autonomously tracks growing microtubule ends and is a bona fide microtubule polymerase. Mal3 recruits additional Dis1 to microtubule ends, explaining the synergistic enhancement of microtubule dynamicity by these proteins. A non-canonical binding motif in Dis1 mediates the interaction with Mal3. X-ray crystallography shows that this new motif interacts in an unconventional configuration with the conserved hydrophobic cavity formed within the Mal3 C-terminal region that typically interacts with the canonical SXIP motif. Selectively perturbing the Mal3–Dis1 interaction in living cells demonstrates that it is important for accurate chromosome segregation. Whereas, in some metazoans, the interaction between EB1 and the XMAP215/TOG family members requires an additional binding partner, fission yeast relies on a direct interaction, indicating evolutionary plasticity of this critical interaction module. PMID:27872152

  15. Short Summary European Reports on Retail Sector, Motor Vehicle Repair and Sales Sector, Food and Beverages Sector.

    ERIC Educational Resources Information Center

    European Centre for the Development of Vocational Training, Berlin (Germany).

    This document is composed of European synthesis reports on retail trade, the agro-food sector, and the motor vehicle sales and repair sector. They are based on the most important findings of the European report and the 12 national reports for each sector. Section 1, "Retail Sector," deals in part 1 with the structure of retailing in the…

  16. Experience and BCC subtypes as determinants of MAL-PDT response: preliminary results of a national Brazilian project.

    PubMed

    Ramirez, Dora P; Kurachi, Cristina; Inada, Natalia M; Moriyama, Lilian T; Salvio, Ana G; Vollet Filho, José D; Pires, Layla; Buzzá, Hilde H; de Andrade, Cintia Teles; Greco, Clovis; Bagnato, Vanderlei S

    2014-03-01

    Non-melanoma skin cancer is the most prevalent cancer type in Brazil and worldwide. Photodynamic therapy (PDT) is a noninvasive technique with excellent cosmetic outcome and good curative results, when used for the initial stages of skin cancer. A Brazilian program was established to determine the efficacy of methyl aminolevulinate (MAL)-PDT, using Brazilian device and drug. The equipment is a dual device that combines the photodiagnosis, based on widefield fluorescence, and the treatment at 630nm. A protocol was defined for the treatment of basal cell carcinoma with 20% MAL cream application. The program also involves the training of the medical teams at different Brazilian regions, and with distinct facilities and previous PDT education. In this report we present the partial results of 27 centers with 366 treated BCC lesions in 294 patients. A complete response (CR) was observed in 76.5% (280/366). The better response was observed for superficial BCC, with CR 160 lesions (80.4%), when compared with nodular or pigmented BCC. Experienced centers presented CR of 85.8% and 90.6% for superficial and nodular BCC respectively. A high influence of the previous doctor experience on the CR values was observed, especially due to a better tumor selection.

  17. Long-term follow-up of metil aminolevulinate (MAL)-PDT in difficult-to-treat cutaneous Bowen's disease.

    PubMed

    Cavicchini, Stefano; Serini, Stefano Maria; Fiorani, Roberta; Girgenti, Valentina; Ghislanzoni, Massimo; Sala, Francesco

    2011-08-01

    Bowen's disease (BD) is a form of intraepidermal squamous cell carcinoma, which is clinically characterized by gradually enlarging, well-demarcated erythematous plaques with irregular borders and surface crusting or scaling, affecting primarily the elderly. BD often presents with lesions difficult to treat with standard therapy as surgery, cryosurgery, or 5-fluorouracil (5-FU) for the risk of significantly poor cosmetic outcome, failure rate, and adverse events, related mainly to the age of the patients. Topical PDT with methyl aminolevulinate (MAL) represents a valid and approved therapy for BD lesions in many cases, especially for lesions located at poor healing sites or for large patches of disease, due to its high efficacy coupled with good tolerability and tissue-sparing attitude. In this study, we sought to investigate the efficacy, safety, and cosmetic outcome of MAL-PDT in a series of patients with BD lesions which were challenging to treat for clinical, surgical, and patient-related reasons, such as size of the lesion, difficult surgical approach for anatomical sites, or age of patients and request of the best cosmetic result. We also performed a long-term follow-up to assess recurrence rates and eventual late-onset adverse events.

  18. Physical properties of the Ce2MAl7Ge4 heavy-fermion compounds (M=Co,Ir,Ni,Pd)

    DOE PAGES

    Ghimire, N. J.; Cary, S. K.; Eley, S.; ...

    2016-05-23

    Here, we report the synthesis, crystal structure, and characterization by means of single-crystal x-ray diffraction, neutron powder diffraction, and magnetic, thermal, and transport measurements of the new heavy-fermion compounds Ce2MAl7Ge4 (M=Co,Ir,Ni,Pd). These compounds crystallize in a noncentrosymmetric tetragonal space group Pmore » $$\\bar{4}$$21m, consisting of layers of square nets of Ce atoms separated by Ge-Al and M-Al-Ge blocks. Ce2CoAl7Ge4,Ce2IrAl7Ge4, and Ce2NiAl7Ge4 order magnetically below TM=1.8, 1.6, and 0.8 K, respectively. There is no evidence of magnetic ordering in Ce2PdAl7Ge4 down to 0.4 K. Furthermore, the small amount of entropy released in the magnetic state of Ce2MAl7Ge4 (M = Co, Ir, Ni) and the reduced specific heat jump at TM suggest a strong Kondo interaction in these materials. Ce2PdAl7Ge4 shows non-Fermi liquid behavior, possibly due to the presence of a nearby quantum critical point.« less

  19. Mal3, the Schizosaccharomyces pombe homolog of EB1, is required for karyogamy and for promoting oscillatory nuclear movement during meiosis.

    PubMed

    Polakova, Silvia; Benko, Zsigmond; Zhang, Lijuan; Gregan, Juraj

    2014-01-01

    Two successive rounds of chromosome segregation following a single round of DNA replication enable the production of haploid gametes during meiosis. In the fission yeast Schizosaccharomyces pombe, karyogamy is the process where the nuclei from 2 haploid cells fuse to create a diploid nucleus, which then undergoes meiosis to produce 4 haploid spores. By screening a collection of S. pombe deletion strains, we found that the deletion of 2 genes, mal3 and mto1, leads to the production of asci containing up to 8 spores. Here, we show that Mal3, the fission yeast member of the EB1 family of conserved microtubule plus-end tracking proteins, is required for karyogamy, oscillatory nuclear movement, and proper segregation of chromosomes during meiosis. In the absence of Mal3, meiosis frequently initiates before the completion of karyogamy, thus producing up to 8 nuclei in a single ascus. Our results provide new evidence that fission yeast can initiate meiosis prior to completing karyogamy.

  20. 50 CFR 648.87 - Sector allocation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Fixed Gear Sector, as defined in § 648.87(d)(1) or (2), joins a new sector, or fishes pursuant to the...) Areas that can be fished. Vessels in a sector may only fish in a particular stock area, as specified in... penalty shall be applied to any member permit/vessel that leaves that sector to fish under the...

  1. 50 CFR 648.87 - Sector allocation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Fixed Gear Sector, as defined in § 648.87(d)(1) or (2), joins a new sector, or fishes pursuant to the...) Areas that can be fished. Vessels in a sector may only fish in a particular stock area, as specified in... penalty shall be applied to any member permit/vessel that leaves that sector to fish under the...

  2. Spatially Enabling the Health Sector

    PubMed Central

    Weeramanthri, Tarun Stephen; Woodgate, Peter

    2016-01-01

    Spatial information describes the physical location of either people or objects, and the measured relationships between them. In this article, we offer the view that greater utilization of spatial information and its related technology, as part of a broader redesign of the architecture of health information at local and national levels, could assist and speed up the process of health reform, which is taking place across the globe in richer and poorer countries alike. In making this point, we describe the impetus for health sector reform, recent developments in spatial information and analytics, and current Australasian spatial health research. We highlight examples of uptake of spatial information by the health sector, as well as missed opportunities. Our recommendations to spatially enable the health sector are applicable to high- and low-resource settings. PMID:27867933

  3. Network topology of economic sectors

    NASA Astrophysics Data System (ADS)

    Djauhari, Maman A.; Gan, Siew Lee

    2016-09-01

    A lot of studies dealing with stock network analysis, where each individual stock is represented by a univariate time series of its closing price, have been published. In these studies, the similarity of two different stocks is quantified using a Pearson correlation coefficient on the logarithmic price returns. In this paper, we generalize the notion of similarity between univariate time series into multivariate time series which might be of different dimensions. This allows us to deal with economic sector network analysis, where the similarity between economic sectors is defined using Escoufier’s vector correlation RV. To the best of our knowledge, there is no study dealing with this notion of economic sector similarity. Two examples of data from the New York stock exchange will be presented and discussed, and some important results will be highlighted.

  4. Economic Indicators of the Farm Sector. Farm Sector Review, 1986.

    ERIC Educational Resources Information Center

    Economic Research Service (USDA), Washington, DC.

    This report contains 44 tables and 23 figures, along with narrative summaries, that provide an overall view of the farm sector in the United States in 1986. Some of the findings highlighted in the report are the following: (1) farmers spent less to produce their crops and livestock in 1986; (2) government payments to farmers increased, but prices…

  5. Inter-Sectoral Educational Planning.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    This book contains papers discussing inter-sectoral educational planning in countries belonging to the Organisation for Economic Co-operation and Development (OECD). Intersectoral educational planning is interpreted as educational policy formation by any country which takes into consideration influences generated by that country's social and…

  6. Infanticide in Limbic (?) Psychotic Trigger Reaction in a man with jacksonian and petit mal (?) seizures: "kindling" by traumatic experiences.

    PubMed

    Pontius, A A

    1990-12-01

    A tenth case (a subtype of complex partial seizures) is proposed as a Limbic (?) Psychotic Trigger Reaction. Upon crying, an infant girl was hit fatally by her devoted father while he was off anticonvulsants prescribed for Jacksonian and petit mal (?) seizures with "porencephalic cyst involving motor cortex and limbic system." Crying revived traumatic memories of frequently repeated ("kindling") experiences of his mother crying when hit by his father, in turn sometimes hit by patient while helping the mother. Hitting also had been helpful (cognitive mismatch between helpful and harmful hitting) during the victim's accidental choking 11 days earlier. This had occurred on the same day his distant mother died. Two days later he attempted suicide with anticonvulsants. Symptoms of the well remembered, unmotivated infanticide included flat affect, olfactory and command hallucinations, and delusions of grandeur (his mother leaving him millions and power).

  7. Mal-Lys: prediction of lysine malonylation sites in proteins integrated sequence-based features with mRMR feature selection

    PubMed Central

    Xu, Yan; Ding, Ya-Xin; Ding, Jun; Wu, Ling-Yun; Xue, Yu

    2016-01-01

    Lysine malonylation is an important post-translational modification (PTM) in proteins, and has been characterized to be associated with diseases. However, identifying malonyllysine sites still remains to be a great challenge due to the labor-intensive and time-consuming experiments. In view of this situation, the establishment of a useful computational method and the development of an efficient predictor are highly desired. In this study, a predictor Mal-Lys which incorporated residue sequence order information, position-specific amino acid propensity and physicochemical properties was proposed. A feature selection method of minimum Redundancy Maximum Relevance (mRMR) was used to select optimal ones from the whole features. With the leave-one-out validation, the value of the area under the curve (AUC) was calculated as 0.8143, whereas 6-, 8- and 10-fold cross-validations had similar AUC values which showed the robustness of the predictor Mal-Lys. The predictor also showed satisfying performance in the experimental data from the UniProt database. Meanwhile, a user-friendly web-server for Mal-Lys is accessible at http://app.aporc.org/Mal-Lys/. PMID:27910954

  8. Step-by-step thermal transformations of a new porous coordination polymer [(H{sub 2}O){sub 5}CuBa(Me{sub 2}mal){sub 2}]{sub n} (Me{sub 2}mal{sup 2-}=dimethylmalonate): Thermal degradation to barium cuprate

    SciTech Connect

    Zauzolkova, Natalya; Dobrokhotova, Zhanna; Lermontov, Anatoly; Zorina, Ekaterina; Emelina, Anna; Bukov, Mikhail; Sidorov, Aleksey; Kiskin, Mikhail; Bogomyakov, Artem; Lytvynenko, Anton; Kolotilov, Sergey; Velikodnyi, Yuriy; Kovba, Maksim

    2013-01-15

    The reactions of CuSO{sub 4}{center_dot}5H{sub 2}O, dimethylmalonic acid and Ba(OH){sub 2}{center_dot}H{sub 2}O (Cu: H{sub 2}Me{sub 2}mal: Ba=1: 2: 2) in aqueous and aqueous-ethanol solutions (H{sub 2}O: EtOH=1: 1) resulted in formation of 3D-porous coordination polymers [(H{sub 2}O){sub 3}({mu}-H{sub 2}O){sub 2}CuBa({mu}{sub 3}-Me{sub 2}mal)(Me{sub 2}mal)]{sub n} (1) and [({mu}-H{sub 2}O)CuBa({mu}{sub 3}-Me{sub 2}mal)({mu}{sub 4}-Me{sub 2}mal)]{sub n} (2), respectively. It has been shown that compound 2 was an intermediate in the thermal degradation of compound 1. Thorough studies of solid-state thermolysis of 1 and 2 allowed to detect formation of coordination polymer [CuBa({mu}{sub 4}-Me{sub 2}mal)({mu}{sub 5}-Me{sub 2}mal)]{sub n} (3), structure of which was determined by X-ray powder diffraction. It has been found that the channels in polymer 3 were accessible for guest molecules (MeOH). Theoretical estimation of methanol diffusion barrier was carried out. Complete solid-phase thermolysis of 1 and 2 leads to a mixture of BaCuO{sub 2}, BaCO{sub 3}, and CuO. Special conditions for obtaining of a crystalline phase of pure cubic BaCuO{sub 2} were determined. - Graphical abstract: Step-by-step transformation of new coordination polymer [(H{sub 2}O){sub 5}CuBa(Me{sub 2}mal){sub 2}]{sub n} to [(H{sub 2}O)CuBa(Me{sub 2}mal){sub 2}]{sub n} and [CuBa(Me{sub 2}mal){sub 2}]{sub n} were performed. Dehydration of initial compound leads to structural changes of 12-membered ring fragment. All compounds have porous structure. The final product of thermal decomposition is crystalline phase of individual cubic BaCuO{sub 2}. Highlights: Black-Right-Pointing-Pointer New 3D-polymers [(H{sub 2}O){sub 5}CuBa(Me{sub 2}mal){sub 2}]{sub n} and [(H{sub 2}O)CuBa(Me{sub 2}mal){sub 2}]{sub n} were synthesized. Black-Right-Pointing-Pointer Thermal analysis showed step-by-step transformations of [(H{sub 2}O){sub 5}CuBa(Me{sub 2}mal){sub 2}]{sub n}. Black-Right-Pointing-Pointer Crystalline

  9. A Comparison of Diarrheal Severity Scores in the MAL-ED Multisite Community-Based Cohort Study

    PubMed Central

    Lee, Gwenyth O.; Richard, Stephanie A.; Kang, Gagandeep; Houpt, Eric R.; Seidman, Jessica C.; Pendergast, Laura L.; Bhutta, Zulfiqar A.; Ahmed, Tahmeed; Mduma, Estomih R.; Lima, Aldo A.; Bessong, Pascal; Jennifer, Mats Steffi; Hossain, Md. Iqbal; Chandyo, Ram Krishna; Nyathi, Emanuel; Lima, Ila F.; Pascal, John; Soofi, Sajid; Ladaporn, Bodhidatta; Guerrant, Richard L.; Caulfield, Laura E.; Black, Robert E.; Kosek, Margaret N.

    2016-01-01

    ABSTRACT Objectives: There is a lack of consensus on how to measure diarrheal severity. Within the context of a multisite, prospective cohort study, we evaluated the performance of a modified Vesikari score (MAL-ED), 2 previously published scores (Clark and CODA [a diarrheal severity score (Community DiarrheA) published by Lee et al]), and a modified definition of moderate-to-severe diarrhea (MSD) based on dysentery and health care worker diagnosed dehydration. Methods: Scores were built using maternally reported symptoms or fieldworker-reported clinical signs obtained during the first 7 days of a diarrheal episode. The association between these and the risk of hospitalization were tested using receiver operating characteristic analysis. Severity scores were also related to illness etiology, and the likelihood of the episode subsequently becoming prolonged or persistent. Results: Of 10,159 episodes from 1681 children, 143 (4.0%) resulted in hospitalization. The area under the curve of each score as a predictor of hospitalization was 0.84 (95% confidence interval: 0.81, 0.87) (Clark), 0.85 (0.82, 0.88) (MAL-ED), and 0.87 (0.84, 0.89) (CODA). Severity was also associated with etiology and episode duration. Although families were more likely to seek care for severe diarrhea, approximately half of severe cases never reached the health system. Conclusions: Community-based diarrheal severity scores are predictive of relevant child health outcomes. Because they require no assumptions about health care access or utilization, they are useful in refining estimates of the burden of diarrheal disease, in estimating the effect of disease control interventions, and in triaging children for referral in low- and middle-income countries in which the rates of morbidity and mortality after diarrhea remain high. PMID:27347723

  10. Printed sectoral horn power combiner

    NASA Astrophysics Data System (ADS)

    Boccia, Luigi; Emanuele, Antonio; Shamsafar, Alireza; Arnieri, Emilio; Amendola, Giandomenico

    2015-02-01

    In this work, it is presented a new configuration of planar power combiner/divider based on an H-plane sectoral horn antenna. This component is proposed to realise the basic building blocks of printed power-combining amplifiers. It will be shown how the sectoral horn elements can be implemented on substrate integrated waveguide and multilayer printed circuit board technologies, thus obtaining a high integration level. In the following, the design procedure will be described reporting an example of an 11-stage power divider/combiner in C-band. A prototype has been fabricated, and the measured results compared with the numerical model. Experimental results are in good agreement with theoretical expectations showing a single-stage efficiency of about 90% and a bandwidth of 40%.

  11. Sectoral shifts and aggregate unemployment

    SciTech Connect

    Loungani, P.

    1986-01-01

    Some recent research has taken the view that sectoral or industry-specific shocks significantly affect aggregate unemployment by increasing the amount of inter-industry labor reallocation required. The empirical evidence for this view rests on the finding that during the 1950s - and again during the 1970s - there was a positive correlation between aggregate unemployment and the dispersion of employment growth rates. This thesis demonstrates that this correlation arises largely because oil price shocks affect both unemployment and the dispersion of employment growth. Once the dispersion due to oil shocks is accounted for, the residual dispersion in employment has very low explanatory power for unemployment. Since the dispersion index does not measure pure sectoral shifts, an alternate measure of dispersion is developed that serves as a better proxy for the amount of inter-industry labor reallocation required each period. Estimates using this measure suggest that, during the 1950s, temporary increases in the relative price of oil were responsible for generating the observed correlation. On the other hand, sectoral shifts were important during the 1970s; in particular, the 1973 oil price increase has had significant reallocative effects on the economy. This contention is subjected to further tests by looking at the time-series behavior of employment in durable-goods industries and also by following the inter-industry movements of workers over time through the use of panel data.

  12. Energy Sector Impacts and Opportunities

    NASA Astrophysics Data System (ADS)

    Newmark, R. L.; Macknick, J.; Martinez, A.; Hallett, K. C.

    2011-12-01

    The power sector is the largest user of freshwater in the U.S. The dominant use of water in power plants is for steam cycle cooling. The current portfolio of electricity generating technologies in the U.S. has highly regionalized and technology-specific requirements for water. Certain areas employ once-through cooling technologies with high withdrawals and low consumptive uses, whereas other areas employ recirculating cooling technologies with relatively low withdrawals but high consumptive uses. As water availability differs widely throughout the nation, assessments of water withdrawal and consumption impacts from the power sector must have a high geographic resolution and consider regional differences. The U.S. electricity portfolio is likely to evolve in coming years, shaped by various energy policies and economic drivers on both the national and regional level, which will impact power sector water demands. It is likely that the U.S. will continue to decarbonize its electricity industry, leading to more low-carbon technologies. However, many low-carbon technologies, such as coal with carbon capture and storage, nuclear, and concentrated solar power, can use more water than the current electricity portfolio average. National- and state-level water policies have been proposed (and enacted) that affect cooling system choices for power plants, with resulting implications for water use as well as power plant installed and operating costs and reliability. Energy policy analyses that do not consider power plant cooling system impacts may miss an important component power plant siting decisions. Similarly, water policies that do not take into consideration potential impacts on power plant operations or comprehensive regional water budget impacts may have deleterious effects on the energy industry. Analysis of future energy scenarios that incorporate technology options and constraints as well as different policies can provide useful insights about likely changes to both

  13. Business and AIDS: sectoral challenges and opportunities.

    PubMed

    Weston, Mark D; Churchyard, Gavin J; Mametja, David; McIntyre, James A; Randera, Fazel

    2007-07-01

    The Business and AIDS think tank held in Durban, South Africa, in June 2006, included a discussion of the policies with which different types of employer could address HIV/AIDS in southern Africa. Breakout groups discussed the role of large and small private sector firms, the public sector, and parastatal organizations. They made recommendations for policies, programmes and future research for each sector.

  14. Dynamically Evolving Sectors for Convective Weather Impact

    NASA Technical Reports Server (NTRS)

    Drew, Michael C.

    2010-01-01

    A new strategy for altering existing sector boundaries in response to blocking convective weather is presented. This method seeks to improve the reduced capacity of sectors directly affected by weather by moving boundaries in a direction that offers the greatest capacity improvement. The boundary deformations are shared by neighboring sectors within the region in a manner that preserves their shapes and sizes as much as possible. This reduces the controller workload involved with learning new sector designs. The algorithm that produces the altered sectors is based on a force-deflection mesh model that needs only nominal traffic patterns and the shape of the blocking weather for input. It does not require weather-affected traffic patterns that would have to be predicted by simulation. When compared to an existing optimal sector design method, the sectors produced by the new algorithm are more similar to the original sector shapes, resulting in sectors that may be more suitable for operational use because the change is not as drastic. Also, preliminary results show that this method produces sectors that can equitably distribute the workload of rerouted weather-affected traffic throughout the region where inclement weather is present. This is demonstrated by sector aircraft count distributions of simulated traffic in weather-affected regions.

  15. Sectoral approaches to improve regional carbon budgets

    SciTech Connect

    Smith, Pete; Nabuurs, Gert-Jan; Marland, Gregg

    2008-06-01

    Humans utilise about 40% of the earth s net primary production (NPP) but the products of this NPP are often managed by different sectors, with timber and forest products managed by the forestry sector and food and fibre products from croplands and grasslands managed by the agricultural sector. Other significant anthropogenic impacts on the global carbon cycle include human utilization of fossil fuels and impacts on less intensively managed systems such as peatlands, wetlands and permafrost. A great deal of knowledge, expertise and data is available within each sector. We describe the contribution of sectoral carbon budgets to our understanding of the global carbon cycle. Whilst many sectors exhibit similarities for carbon budgeting, some key differences arise due to differences in goods and services provided, ecology, management practices used, landmanagement personnel responsible, policies affecting land management, data types and availability, and the drivers of change. We review the methods and data sources available for assessing sectoral carbon budgets, and describe some of key data limitations and uncertainties for each sector in different regions of the world. We identify the main gaps in our knowledge/data, show that coverage is better for the developed world for most sectors, and suggest how sectoral carbon budgets could be improved in the future. Research priorities include the development of shared protocols through site networks, a move to full carbon accounting within sectors, and the assessment of full greenhouse gas budgets.

  16. Macroscopic theory of dark sector

    NASA Astrophysics Data System (ADS)

    Meierovich, Boris

    A simple Lagrangian with squared covariant divergence of a vector field as a kinetic term turned out an adequate tool for macroscopic description of the dark sector. The zero-mass field acts as the dark energy. Its energy-momentum tensor is a simple additive to the cosmological constant [1]. Space-like and time-like massive vector fields describe two different forms of dark matter. The space-like massive vector field is attractive. It is responsible for the observed plateau in galaxy rotation curves [2]. The time-like massive field displays repulsive elasticity. In balance with dark energy and ordinary matter it provides a four parametric diversity of regular solutions of the Einstein equations describing different possible cosmological and oscillating non-singular scenarios of evolution of the universe [3]. In particular, the singular big bang turns into a regular inflation-like transition from contraction to expansion with the accelerate expansion at late times. The fine-tuned Friedman-Robertson-Walker singular solution corresponds to the particular limiting case at the boundary of existence of regular oscillating solutions in the absence of vector fields. The simplicity of the general covariant expression for the energy-momentum tensor allows to analyse the main properties of the dark sector analytically and avoid unnecessary model assumptions. It opens a possibility to trace how the additional attraction of the space-like dark matter, dominating in the galaxy scale, transforms into the elastic repulsion of the time-like dark matter, dominating in the scale of the Universe. 1. B. E. Meierovich. "Vector fields in multidimensional cosmology". Phys. Rev. D 84, 064037 (2011). 2. B. E. Meierovich. "Galaxy rotation curves driven by massive vector fields: Key to the theory of the dark sector". Phys. Rev. D 87, 103510, (2013). 3. B. E. Meierovich. "Towards the theory of the evolution of the Universe". Phys. Rev. D 85, 123544 (2012).

  17. Malonate-containing manganese(III) complexes: synthesis, crystal structure, and magnetic properties of AsPh4[Mn(mal)2(H2O)2].

    PubMed

    Delgado, Fernando S; Kerbellec, Nicolas; Ruiz-Pérez, Catalina; Cano, Joan; Lloret, Francesc; Julve, Miguel

    2006-02-06

    The novel manganese(III) complexes PPh4[Mn(mal)2(H2O)2] (1) and AsPh4[Mn(mal)2(H2O)2] (2) (PPh4+ = tetraphenylphosphonium cation, AsPh4+ = tetraphenylarsonium cation, and H2mal = malonic acid) have been prepared, and the structure of 2 was determined by X-ray diffraction analysis. 2 is a mononuclear complex whose structure is made up of trans-diaquabis(malonato)manganate(III) units and tetraphenylarsonium cations. Two crystallographically independent manganese(III) ions (Mn(1) and Mn(2)) occur in 2 that exhibit elongated octahedral surroundings with four oxygen atoms from two bidentate malonate groups in equatorial positions (Mn(1)-O = 1.923(6) and 1.9328(6) A and Mn(2)-O = 1.894(6) and 1.925(6) A) and two trans-coordinated water molecules in the axial sites (Mn(1)-Ow = 2.245(6) A and Mn(2)-Ow = 2.268(6) A). The [Mn(mal)2(H2O)2]- units are linked through hydrogen bonds involving the free malonate-oxygen atoms and the coordinated water molecules to yield a quasi-square-type anionic layer growing in the ab plane. The shortest intralayer metal-metal separations are 7.1557(7) and 7.1526(7) A (through the edges of the square). The anionic sheets are separated from each other by layers of AsPh4+ where sextuple- and double-phenyl embraces occur. The magnetic behavior of 1 and 2 in the temperature range 1.9-290 K reveals the occurrence of weak intralayer ferromagnetic interactions (J = +0.081(1) (1) and +0.072(2) cm(-1) (2)). These values are compared to those of the weak antiferromagnetic coupling [J = -0.19(1) cm(-1)], which is observed in the chain compound K2[Mn(mal)2(MeOH)2][Mn(mal)2] (3), where the exchange pathway involves the carboxyate-malonate bridge in the anti-syn conformation. The structure of 3 was reported elsewhere. Theoretical calculations on fragment models of 2 and 3 were performed to analyze and substantiate both the nature and magnitude of the magnetic couplings observed.

  18. Probing the string winding sector

    NASA Astrophysics Data System (ADS)

    Aldazabal, Gerardo; Mayo, Martín; Nuñez, Carmen

    2017-03-01

    We probe a slice of the massive winding sector of bosonic string theory from toroidal compactifications of Double Field Theory (DFT). This string subsector corresponds to states containing one left and one right moving oscillators. We perform a generalized Kaluza Klein compactification of DFT on generic 2 n-dimensional toroidal constant backgrounds and show that, up to third order in fluctuations, the theory coincides with the corresponding effective theory of the bosonic string compactified on n-dimensional toroidal constant backgrounds, obtained from three-point amplitudes. The comparison between both theories is facilitated by noticing that generalized diffeomorphisms in DFT allow to fix generalized harmonic gauge conditions that help in identifying the physical degrees of freedom. These conditions manifest as conformal anomaly cancellation requirements on the string theory side. The explicit expression for the gauge invariant effective action containing the physical massless sector (gravity+antisymmetric+gauge+ scalar fields) coupled to towers of generalized Kaluza Klein massive states (corresponding to compact momentum and winding modes) is found. The action acquires a very compact form when written in terms of fields carrying O( n, n) indices, and is explicitly T-duality invariant. The global algebra associated to the generalized Kaluza Klein compactification is discussed.

  19. Responsible leader behavior in health sectors.

    PubMed

    Longest, Beaufort

    2017-02-06

    Purpose The purpose of this paper is to expand attention to responsible leader behavior in the world's health sectors by explaining how this concept applies to health sectors, considering why health sector leaders should behave responsibly, reviewing how they can do so, and asserting potential impact through an applied example. Design/methodology/approach This paper is a viewpoint, reflecting conceptualizations rooted in leadership literature which are then specifically applied to health sectors. A definition of responsible leader behavior is affirmed and applied specifically in health sectors. Conceptualizations and viewpoints about practice of responsible leader behavior in health sectors and potential consequences are then discussed and asserted. Findings Leadership failures and debacles found in health, but more so in other sectors, have led leadership researchers to offer insights, many of them empirical, into the challenges of leadership especially by more clearly delineating responsible leader behavior. Practical implications Much of what has been learned in the research about responsible leader behavior offers pathways for health sector leaders to more fully practice responsible leadership. Social implications This paper asserts and provides a supporting example that greater levels of responsible leader behavior in health sectors hold potentially important societal benefits. Originality/value This paper is the first to apply emerging conceptualizations and early empirical findings about responsible leader behavior specifically to leaders in health sectors.

  20. Structure, spectroscopy, and theory calculations of mononuclear mixed-ligand copper(II) complex with malonate and 2-propylimidazole, [Cu(mal)(PIM) 2(H 2O)

    NASA Astrophysics Data System (ADS)

    Peng, Xian; Cui, Guang-Hua; Li, De-Jie; Wu, Shang-Zhuo; Yu, Ya-Mei

    2010-05-01

    A mononuclear copper(II) complex, [Cu(mal)(PIM) 2(H 2O)] (1) [mal = malonate dianion, PIM = 2-propylimidazole] has been synthesized and characterized by elemental analysis, IR, UV-Vis, TG-DTA, and single crystal X-ray diffraction. The center Cu(II) atom in the complex has a distorted square-pyramidal geometry, being coordinated by two nitrogen atoms and three oxygen atoms. Density Functional Theory (DFT) with the B3LYP method and time-dependent DFT calculations were performed to provide insight into the structural, electronic, and electronic spectroscopic properties of the complex 1, and the UV-Vis spectrum of the title compound has been discussed on this basis. All the absorption bands in UV-Vis spectrum are mostly π/( P, σ) → d x2-y2 ligand-to-metal charge transfer (LMCT) transition, together with partial d → d ligand field (LF) transition.

  1. Quality and disinfection trials of consumption water in storage reservoirs for rural area in the Marrakech region (Assif El Mal).

    PubMed

    Aziz, Faissal; Mandi, Laila; Boussaid, Abdellatif; Boraam, Fatima; Ouazzani, Naaila

    2013-03-01

    Traditional reservoirs for water storage are important systems of water supply in rural areas of Morocco. These reservoirs are fed by rainwater and/or directly from rivers through open channels; the stored water is used without any treatment as drinking water by the surrounding population. The present study aimed to assess the physicochemical and bacteriological quality of stored water and the corresponding sediment in six traditional reservoirs (R1 to R6) located in the rural municipality of Assif El Mal. We tested two inexpensive methods of disinfecting the stored water: chlorination and solar disinfection in bottles. The results show a rise of organic and mineral concentrations. Regarding bacteriological quality, a critical contamination level was detected (8 × 10(5) CFU/100 ml in water and 9 × 10(7) CFU/g in sediment) according to the 2002 Moroccan Standards for drinking water (0 CFU/100 ml). In the disinfection tests, chlorine disinfection removed all studied germs after just 1 hour, and the solar exposure process removed the majority of bacteria (after 3 hours) except those with a resistant form (Clostridia).

  2. Genetic threshold hypothesis of neocortical spike-and-wave discharges in the rat: An animal model of petit mal epilepsy

    SciTech Connect

    Vadasz, C.; Fleischer, A.; Carpi, D.; Jando, G.

    1995-02-27

    Neocortical high-voltage spike-and-wave discharges (HVS) in the rat are an animal model of petit mal epilepsy. Genetic analysis of total duration of HVS (s/12 hr) in reciprocal F1 and F2 hybrids of F344 and BN rats indicated that the phenotypic variability of HVS cannot be explained by simple, monogenic Mendelian model. Biometrical analysis suggested the presence of additive, dominance, and sex-linked-epistatic effects, buffering maternal influence, and heterosis. High correlation was observed between average duration (s/episode) and frequency of occurrence of spike-and-wave episodes (n/12 hr) in parental and segregating generations, indicating that common genes affect both duration and frequency of the spike-and-wave pattern. We propose that both genetic and developmental - environmental factors control an underlying quantitative variable, which, above a certain threshold level, precipitates HVS discharges. These findings, together with the recent availability of rat DNA markers for total genome mapping, pave the way to the identification of genes that control the susceptibility of the brain to spike-and-wave discharges. 67 refs., 3 figs., 5 tabs.

  3. The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT

    NASA Astrophysics Data System (ADS)

    Tyrrell, Jessica; Campbell, Sandra; Curnow, Alison

    2009-06-01

    This study employed a commercially available, non-invasive, fluorescence imaging system (Dyaderm, Biocam, Germany), to measure protoporphyrin IX (PpIX) concentration at several different stages during clinical dermatological methyl aminolevulinate photodynamic therapy (MAL-PDT). We validated the system prior to use to ensure that the PpIX changes witnessed were accurate and not due to environmental or user induced artifacts. The system was then employed to acquire color (morphological) and fluorescent (physiological) images simultaneously during dermatological PDT. Clinical data was collected from a range of licensed dermatological conditions (actinic keratosis, Bowen's disease and superficial basal cell carcinoma) during initial and subsequent PDT treatment cycles. The initial clinical data indicated that each type of licensed lesion considered responded in a similar manner following the application of Metvix (Galderma, U.K.) and the subsequent light irradiation (Aktilite, Galderma, U.K.). Images acquired three hours after Metvix application showed a significant increase in PpIX concentration within the lesion (P < 0.05), whilst PpIX levels in the surrounding normal tissue remained unaltered. After irradiation, the PpIX concentration was significantly decreased and returned to a level similar to the initial concentration originally observed. Lesions that received subsequent treatment cycles accumulated significantly less PpIX (P < 0.05) prior to irradiation.

  4. Genetic threshold hypothesis of neocortical spike-and-wave discharges in the rat: an animal model of petit mal epilepsy.

    PubMed

    Vadász, C; Carpi, D; Jando, G; Kandel, A; Urioste, R; Horváth, Z; Pierre, E; Vadi, D; Fleischer, A; Buzsáki, G

    1995-02-27

    Neocortical high-voltage spike-and-wave discharges (HVS) in the rat are an animal model of petit mal epilepsy. Genetic analysis of total duration of HVS (s/12 hr) in reciprocal F1 and F2 hybrids of F344 and BN rats indicated that the phenotypic variability of HVS cannot be explained by a simple, monogenic Mendelian model. Biometrical analysis suggested the presence of additive, dominance, and sex-linked-epistatic effects, buffering maternal influence, and heterosis. High correlation was observed between average duration (s/episode) and frequency of occurrence of spike-and-wave episodes (n/12 hr) in parental and segregating generations, indicating that common genes affect both duration and frequency of the spike-and-wave pattern. We propose that both genetic and developmental-environmental factors control an underlying quantitative variable, which, above a certain threshold level, precipitates HVS discharges. These findings, together with the recent availability of rat DNA markers for total genome mapping, pave the way to the identification of genes that control the susceptibility of the brain to spike-and-wave discharges.

  5. Investigation of the physical properties of the tetragonal CeMAl4Si2 (M = Rh, Ir, Pt) compounds

    SciTech Connect

    Ghimire, N. J.; Ronning, F.; Williams, D. J.; Scott, B. L.; Luo, Yongkang; Thompson, J. D.; Bauer, E. D.

    2014-12-15

    The synthesis, crystal structure and physical properties studied by means of x-ray diffraction, magnetic, thermal and transport measurements of CeMAl4Si2 (M = Rh, Ir, Pt) are reported, along with the electronic structure calculations for LaMAl4Si2 (M = Rh, Ir, Pt). These materials adopt a tetragonal crystal structure (space group P4/mmm) comprised of BaAl4 blocks, separated by MAl2 units, stacked along the c-axis. Both CeRhAl4Si2 and CeIrAl4Si2 order antiferromagnetically below TN1 = 14 and 16 K, respectively, and undergo a second antiferromagnetic transitition at lower temperature (TN2 = 9 and 14 K, respectively). CePtAl4Si2 orders ferromagnetically below TC = 3 K with an ordered moment of μsat = 0.8 μB for a magnetic field applied perpendicular to the c-axis. Electronic structure calculations reveal quasi-2D character of the Fermi surface.

  6. TLR4-MyD88/Mal-NF-kB axis is involved in infection of HSV-2 in human cervical epithelial cells.

    PubMed

    Liu, Hongya; Chen, Kai; Feng, Wenqiang; Wu, Xinxing; Li, Hui

    2013-01-01

    We have established an in vitro HSV-2 acute infection model with Human cervical epithelial (HCE cells, the primary target and natural host cells for HSV-2) to investigate the role of TLRs-mediated innate immune response to HSV-2. In current study, we found that HSV-2 infection induced activity of NF-kB reporter and expression of cytokines are TLR4-dependent using approaches with shRNA and TLR4 antagonist. Knockdown experiments demonstrated that the adaptor molecules MyD88 and Mal of the TLRs signaling pathway are required in the HSV-2 induced TLR4-dependent NF-kB activation in HCE cells. Western blot assay suggested that knockdown of TLR4 decreased the phosphorylation of IRAK1 and inhibitor of NF-kB (IkB-α) upon HSV-2 infection. Finally, decreased expression of either TLR4 or MyD88/Mal alone or both significantly abolished productions of IL-6 and IFN-β by ELISA analysis. Taken together, our results from the in vitro infection model reveal for the first time that there exists the pathway via TLR4-Mal/MyD88-IRAK1-NF-kB axis in human cervical epithelial cells in response to HSV-2 infection.

  7. Transglycosylation properties of maltodextrin glucosidase (MalZ) from Escherichia coli and its application for synthesis of a nigerose-containing oligosaccharide

    SciTech Connect

    Song, Kyung-Mo; Shim, Jae-Hoon; Park, Jong-Tae; Kim, Sung-Hee; Kim, Young-Wan; Boos, Winfried; Park, Kwan-Hwa

    2010-06-18

    The transglycosylation reaction of maltodextrin glucosidase (MalZ) cloned and purified from Escherichia coli K12 was characterized and applied to the synthesis of branched oligosaccharides. Purified MalZ preferentially catalyzed the hydrolysis of maltodextrin, {gamma}-cyclodextrin (CD), and cycloamylose (CA). In addition, when the enzyme was incubated with 5% maltotriose (G3), a series of transfer products were produced. The resulting major transfer products, annotated as T1, T2, and T3, were purified and their structures were determined by TLC, MALDI-TOF/MS, {sup 13}C NMR, and enzymatic analysis. T1 was identified as a novel compound, maltosyl {alpha}-1,3-maltose, whereas T2 and T3 were determined to be isopanose and maltosyl-{alpha}-1,6-maltose, respectively. These results indicated that MalZ transferred sugar moiety mainly to C-3 or C-6-OH of glucose of the acceptor molecule. To obtain highly concentrated transfer products, the enzyme was reacted with 10% liquefied cornstarch, and then glucose and maltose were removed by immobilized yeast. The T1 content of the resulting reaction mixture reached 9.0%. The mixture of T1 containing a nigerose moiety can have an immunopotentiating effect on the human body and may be a potential functional sugar stuff.

  8. Analysis of the Free Energy Landscapes for the Opening-Closing Dynamics of the Maltose Transporter ATPase MalK2 Using Enhanced-Sampling Molecular Dynamics Simulation.

    PubMed

    Hsu, Wei-Lin; Furuta, Tadaomi; Sakurai, Minoru

    2015-07-30

    Protein dynamics are considered significant for many physiological processes, such as metabolism, biomolecular recognition, and the regulation of several vital cellular processes. Due to their flexibility, proteins may stay in different substates with or without the existence of the cognate substrates. To describe these phenomena, two models have been proposed: the "induced fit" and the "conformational selection" mechanisms. In this study, we used MalK2, the subunits that mainly include the nucleotide-binding domains (NBDs) of the maltose transporter from Escherichia coli, as a target to understand the NBD dimerization mechanism. Accelerated and conventional molecular dynamics have been performed. The results revealed that Mg-ATP binding to MalK2 led to a significant change in the free energy profile and thus stabilized the closed conformation. On the contrary, when Mg-ATP was removed, the open conformation would be favored. The fact that ligand binding induces a drastic free energy change leads to a significant inference: MalK2 dimerization would occur through the induced-fit mechanism rather than the conformational selection mechanism. This study sheds new light on the NBD dimerization mechanism and would be of wide applicability to other ABC transporters.

  9. Research Frontiers in Public Sector Performance Measurement

    NASA Astrophysics Data System (ADS)

    Zhonghua, Cai; Ye, Wang

    In "New Public Management" era, performance measurement has been widely used in managerial practices of public sectors. From the content and features of performance measurement, this paper aims to explore inspirations on Chinese public sector performance measurement, which based on a review of prior literatures including influencial factors, methods and indicators of public sector performance evaluation. In the end, arguments are presented in this paper pointed out the direction of future researches in this field.

  10. Security Force Assistance and Security Sector Reform

    DTIC Science & Technology

    2013-09-01

    development, and planning, 63 Shultz: Security Force Assistance and Security Sector Reform budgeting and management are critical in reforming a defense...and Security Sector Reform Richard H. Shultz, Jr. JSOU Report 13-5 September 2013 Joint Special Operations University 7701 Tampa Point Boulevard...Assistance and Security Sector Reform 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK

  11. Healthcare and Social Assistance Sector (NAICS 62)

    EPA Pesticide Factsheets

    Environmental regulations and information for the Healthcare sector, including doctor's offices, hospitals, and medical laboratories. Includes information about dental amalgam wastewater, sterilizers, and medical waste.

  12. MALS: an efficient strategy for multiple site-directed mutagenesis employing a combination of DNA amplification, ligation and suppression PCR

    PubMed Central

    Fushan, Alexey A; Drayna, Dennis T

    2009-01-01

    Background Multiple approaches for the site-directed mutagenesis (SDM) have been developed. However, only several of them are designed for simultaneous introduction of multiple nucleotide alterations, and these are time consuming. In addition, many of the existing multiple SDM methods have technical limitations associated with type and number of mutations that can be introduced, or are technically demanding and require special chemical reagents. Results In this study we developed a quick and efficient strategy for introduction of multiple complex mutations in a target DNA without intermediate subcloning by using a combination of connecting SDM and suppression PCR. The procedure consists of sequential rounds, with each individual round including PCR amplification of target DNA with two non-overlapping pairs of oligonucleotides. The desired mutation is incorporated at the 5' end of one or both internal oligonucleotides. DNA fragments obtained during amplification are mixed and ligated. The resulting DNA mixture is amplified with external oligonucleotides that act as suppression adapters. Suppression PCR limits amplification to DNA molecules representing full length target DNA, while amplification of other types of molecules formed during ligation is suppressed. To create additional mutations, an aliquot of the ligation mixture is then used directly for the next round of mutagenesis employing internal oligonucleotides specific for another region of target DNA. Conclusion A wide variety of complex multiple mutations can be generated in a short period of time. The procedure is rapid, highly efficient and does not require special chemical reagents. Thus, MALS represents a powerful alternative to the existing methods for multiple SDM. PMID:19778447

  13. Three-dimensional corrective osteotomies of mal-united clavicles--is the contralateral anatomy a reliable template for reconstruction?

    PubMed

    Hingsammer, Andreas M; Lazaros, Vlachopoulos; Dominik, Meyer C; Fürnstahl, Philipp

    2015-10-01

    In computer-assisted preoperative planning of corrective osteotomies, the unaffected contralateral bone often serves as three-dimensional template for the reconstruction of mal-united bones. Before applying this approach to new anatomy such as the clavicle bone, it is important to study asymmetry between the sides. The purpose of this study was to investigate bilateral symmetry of the clavicle in healthy cadavers using three-dimensional measurement techniques. Bilateral symmetry of 102 clavicles (51 cadavers, mean age: 52.19 years, 37 male) was measured based on three-dimensional models reconstructed from computed tomography. Besides length, volume, and surface, the side-differences were evaluated by considering the mirrored left clavicle as the reconstruction template and the right clavicle as the one that will be realigned by osteotomy. The relative transformation between the aligned segments was measured to express the difference with to three-dimensional translation and rotation. The same procedure was repeated using mean-sized clavicles, one for each gender, as the template. The contralateral side was a significant more accurate reconstruction template compared to a mean-sized clavicle (P < 0.001). Nevertheless, an average side-differences with respect to rotation and translation of 8.79° ± 5.2° and 3.5 mm ± 2.7 mm, respectively. The left clavicles were significant (P = 0.001) longer with 154 mm compared to the right ones (151 mm). Three-dimensional differences between the left and right clavicles exist, but can be considered as small. Therefore, the contralateral side appears to be a reliable reconstruction template, in particular compared to a mean-sized clavicle.

  14. Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys.

    PubMed

    Young, Mark A; Malavalli, Ashok; Winslow, Nancy; Vandegriff, Kim D; Winslow, Robert M

    2007-06-01

    Maleimide-polyethylene glycol-modified (MalPEG) hemoglobin, 4.3 g/dL (MP4; Hemospan), is a hemoglobin-based oxygen carrier consisting of human hemoglobin (Hb) modified with maleimide polyethylene glycol. This study evaluates the potential toxicity and hemodynamic actions of a single dose of MP4 administered by exchange transfusion to rhesus monkeys. Monkeys were administered MP4 (21 mL/kg, or approximately 30% of estimated blood volume) or an equivalent volume of lactated Ringer's solution (LR). In the toxicity study, blood samples were obtained predose and 3, 7, and 13 days after dosing for clinical chemistry and hematology. Animals were euthanized for complete necropsy and histopathology on day 3 or day 13. A separate group of animals was used for evaluation of arterial pressure, core temperature, and electrocardiogram, by telemetry, for 7 days after dosing with MP4. The results demonstrate no significant toxicity, with only modest, transient elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) on day 3. Mild anemia caused by hemodilution was observed at each time point in both groups, but to a slightly greater degree in the MP4-treated animals. Histologic observations included foamy or vacuolated macrophages in the spleen and marrow of the sternum, rib, and femur, representing the accumulation of test article or a metabolite. In the telemetry study, no changes occurred in arterial pressure, heart rate, or electrocardiogram attributable to administration of MP4 at any time for 7 days after administration. These results demonstrate that MP4 is safe and is without hemodynamic effects when administered as an exchange transfusion of 30% of estimated blood volume.

  15. Cost effectiveness of OptiMal® rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil

    PubMed Central

    2010-01-01

    Background In areas with limited structure in place for microscopy diagnosis, rapid diagnostic tests (RDT) have been demonstrated to be effective. Method The cost-effectiveness of the Optimal® and thick smear microscopy was estimated and compared. Data were collected on remote areas of 12 municipalities in the Brazilian Amazon. Data sources included the National Malaria Control Programme of the Ministry of Health, the National Healthcare System reimbursement table, hospitalization records, primary data collected from the municipalities, and scientific literature. The perspective was that of the Brazilian public health system, the analytical horizon was from the start of fever until the diagnostic results provided to patient and the temporal reference was that of year 2006. The results were expressed in costs per adequately diagnosed cases in 2006 U.S. dollars. Sensitivity analysis was performed considering key model parameters. Results In the case base scenario, considering 92% and 95% sensitivity for thick smear microscopy to Plasmodium falciparum and Plasmodium vivax, respectively, and 100% specificity for both species, thick smear microscopy is more costly and more effective, with an incremental cost estimated at US$549.9 per adequately diagnosed case. In sensitivity analysis, when sensitivity and specificity of microscopy for P. vivax were 0.90 and 0.98, respectively, and when its sensitivity for P. falciparum was 0.83, the RDT was more cost-effective than microscopy. Conclusion Microscopy is more cost-effective than OptiMal® in these remote areas if high accuracy of microscopy is maintained in the field. Decision regarding use of rapid tests for diagnosis of malaria in these areas depends on current microscopy accuracy in the field. PMID:20937094

  16. Private Sector Contracting and Democratic Accountability

    ERIC Educational Resources Information Center

    DiMartino, Catherine; Scott, Janelle

    2013-01-01

    Public officials are increasingly contracting with the private sector for a range of educational services. With much of the focus on private sector accountability on cost-effectiveness and student performance, less attention has been given to shifts in democratic accountability. Drawing on data from the state of New York, one of the most active…

  17. Do Sectoral Training Funds Stimulate Training?

    ERIC Educational Resources Information Center

    Kamphuis, Pascal; Glebbeek, Arie C.; Van Lieshout, Harm

    2010-01-01

    Sectoral levelling funds are an arrangement aimed at alleviating a well-known theoretical problem of underinvestment in worker training because of free-rider behaviour of firms. In the Netherlands, collective agreements require firms to participate in such funds in a number of sectors. Using a comprehensive dataset of Dutch firms, we attempt to…

  18. Entrepreneurship Education: Towards an Industry Sector Approach

    ERIC Educational Resources Information Center

    Richardson, Ita; Hynes, Briga

    2008-01-01

    Purpose: The purpose of this paper is to consider the requirements for an industry sector approach to entrepreneurship education--the information and communications technology (ICT) sector. A modified Process Framework for Entrepreneurship Education is presented focusing specifically on ICT. The primary components of the Process Framework are…

  19. Motivating the Private vs. Public Sector Managers.

    ERIC Educational Resources Information Center

    Khojasteh, Mak

    1993-01-01

    A questionnaire on intrinsic/extrinsic rewards received 362 responses from 380 managers. Pay and security were greater motivators for private than for public sector managers. Recognition had higher motivating potential in the public sector. Both groups were motivated by achievement and advancement. (SK)

  20. 33 CFR 84.17 - Horizontal sectors.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.17 Horizontal sectors. (a)(1... intensities. The intensities shall decrease to reach practical cut-off between 1 and 3 degrees outside the prescribed sectors. (2) For sternlights and masthead lights and at 22.5 degrees abaft the beam for...

  1. 33 CFR 84.19 - Vertical sectors.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... required intensity of electric lights as fitted shall be maintained on the horizontal. (d) In the case of... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.19 Vertical sectors. (a) The vertical sectors of electric lights as fitted, with the exception of lights on sailing vessels underway...

  2. 33 CFR 84.19 - Vertical sectors.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... required intensity of electric lights as fitted shall be maintained on the horizontal. (d) In the case of... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.19 Vertical sectors. (a) The vertical sectors of electric lights as fitted, with the exception of lights on sailing vessels underway...

  3. 33 CFR 84.19 - Vertical sectors.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... required intensity of electric lights as fitted shall be maintained on the horizontal. (d) In the case of... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.19 Vertical sectors. (a) The vertical sectors of electric lights as fitted, with the exception of lights on sailing vessels underway...

  4. 33 CFR 84.19 - Vertical sectors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... required intensity of electric lights as fitted shall be maintained on the horizontal. (d) In the case of... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.19 Vertical sectors. (a) The vertical sectors of electric lights as fitted, with the exception of lights on sailing vessels underway...

  5. 33 CFR 84.17 - Horizontal sectors.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.17 Horizontal sectors. (a)(1... intensities. The intensities shall decrease to reach practical cut-off between 1 and 3 degrees outside the prescribed sectors. (2) For sternlights and masthead lights and at 22.5 degrees abaft the beam for...

  6. 33 CFR 84.19 - Vertical sectors.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... required intensity of electric lights as fitted shall be maintained on the horizontal. (d) In the case of... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.19 Vertical sectors. (a) The vertical sectors of electric lights as fitted, with the exception of lights on sailing vessels underway...

  7. 33 CFR 84.17 - Horizontal sectors.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... RULES ANNEX I: POSITIONING AND TECHNICAL DETAILS OF LIGHTS AND SHAPES § 84.17 Horizontal sectors. (a)(1... intensities. The intensities shall decrease to reach practical cut-off between 1 and 3 degrees outside the prescribed sectors. (2) For sternlights and masthead lights and at 22.5 degrees abaft the beam for...

  8. FORCE Sectoral Survey on European Retail Trade.

    ERIC Educational Resources Information Center

    Bertzeletou, Tina

    1993-01-01

    A sectoral survey focused on ways in which vocational training plans are formulated and analysis of the cost effectiveness of continuing vocational training at the company level. It examined techniques applied to developing continuing vocational training and improving access. National surveys carried out for the retail trade sector revealed…

  9. National Electric Sector Cybersecurity Organization Resource (NESCOR)

    SciTech Connect

    None, None

    2014-06-30

    The goal of the National Electric Sector Cybersecurity Organization Resource (NESCOR) project was to address cyber security issues for the electric sector, particularly in the near and mid-term. The following table identifies the strategies from the DOE Roadmap to Achieve Energy Delivery Systems Cybersecurity published in September 2011 that are applicable to the NESCOR project.

  10. Dark Sectors 2016 Workshop: Community Report

    SciTech Connect

    Alexander, Jim; et al.

    2016-08-30

    This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years.

  11. 50 CFR 648.87 - Sector allocation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... new sector, or fishes pursuant to the provisions of the common pool. (i) GB cod PSC for permits... only fish in a particular stock area, as specified in paragraphs (b)(1)(ii)(A) through (F) of this... penalty shall be applied to any member permit/vessel that leaves that sector to fish under the...

  12. Youth Employment in the Hospitality Sector.

    ERIC Educational Resources Information Center

    Schiller, Bradley R.

    A study used data from the National Longitudinal Surveys of Youth to analyze the long-term effects of hospitality industry employment on youth. The subsample extracted for the study included all youth who were aged 16-24 in 1980 and employed in the civilian sector for pay at any time in the year. Statistics indicated the hospitality sector was…

  13. Mixed-Sector Tertiary Education. Research Overview

    ERIC Educational Resources Information Center

    Moodie, Gavin

    2012-01-01

    This research overview provides the key messages arising from two related projects investigating tertiary education institutions that have recently begun to offer tertiary programs outside the sector of their initial establishment and the sector of the majority of their enrolments. These are TAFE institutes offering higher education programs,…

  14. The Economic Effects of a Booming Sector.

    ERIC Educational Resources Information Center

    Corden, W. M.

    1983-01-01

    Since the 1970s, economists have recognized that a booming export sector of the economy can have unfortunate consequences for other sectors and lead to both appreciation of that nation's currency and a weakening position for its exports. A model to stimulate the effects of this situation is discussed. (IS)

  15. Labor in the Public and Nonprofit Sectors.

    ERIC Educational Resources Information Center

    Hamermesh, Daniel S., Ed.

    Originally presented at a Conference on Labor in Nonprofit Industry and Government held at Princeton University, the studies are the first to provide an economic discussion of the public sector labor market. Melvin Reder examines the effect of the absence of the profit motive on employment and wage determination in the public sector. Orley…

  16. Education and Human Resources Sector Assessment Manual.

    ERIC Educational Resources Information Center

    Pigozzi, Mary Joy; Cieutat, Victor J.

    This manual endorses and adopts the sector-assessment approach for planning and managing the allocation of educational resources. Chapter 1 presents the manual's goals. Chapter 2 describes the manual's content and information sources, explains the term "sector assessment," identifies the groups that benefit from recommendations made by…

  17. Dimensions of the Independent Sector: A Statistical Profile. Second Edition.

    ERIC Educational Resources Information Center

    Hodgkinson, Virginia Ann; Weitzman, Murray S.

    The second in a biennial series of statistical profiles of the independent sector (voluntary sector, third sector, or nonprofit sector) describes and charts the activities of groups and individuals associated with this sector. Included are voluntary organizations, foundations, the social responsibility programs of corporations, and people who…

  18. Air Traffic Sector Configuration Change Frequency

    NASA Technical Reports Server (NTRS)

    Chatterji, Gano B.; Drew, Michael

    2010-01-01

    A Mixed Integer Linear Programming method is used for creating sectors in Fort Worth, Cleveland, and Los Angeles centers based on several days of good-weather traffic data. The performance of these sectors is studied when they are subjected to traffic data from different days. Additionally, the advantage of using different sector designs at different times of day with varying traffic loads is examined. Specifically, traffic data from 10 days are used for design, and 47 other days are played back to test if the traffic-counts stay below the design values used in creating the partitions. The primary findings of this study are as follows. Sectors created with traffic from good-weather days can be used on other good-weather days. Sector configurations created with two hours of traffic can be used for 6 to 12 hours without exceeding the peak-count requirement. Compared to using a single configuration for the entire day, most of the sector-hour reduction is achieved by using two sector configurations -one during daytime hours and one during nighttime hours.

  19. Acid deposition research in the private sector

    SciTech Connect

    Kinsman, J.D.; Wisniewski, J.; Nelson, J.

    1984-02-01

    Acid deposition research funded by the private sector since 1980 is reviewed. Types of studies (e.g., atmospheric processes, emissions and monitoring, environmental effects) supported by the private sector during this period are overviewed. The specific industries/organizations (e.g., electric utility industry, environmental interest groups) funding reserach during 1980-1982 are discussed, with relation to the number of studies supported and funds (by year) provided by each. Finally, 13 research projects supported by the private sector and initiated by December 1983, each at greater than $1 million, are described.

  20. Grand Mal Seizure

    MedlinePlus

    ... generalized tonic-clonic seizure — features a loss of consciousness and violent muscle contractions. It's the type of ... seizures have two stages: Tonic phase. Loss of consciousness occurs, and the muscles suddenly contract and cause ...

  1. Crystallization, data collection and data processing of maltose-binding protein (MalE) from the phytopathogen Xanthomonas axonopodis pv. citri.

    PubMed

    Souza, C S; Ferreira, L C S; Thomas, L; Barbosa, J A R G; Balan, A

    2009-02-01

    Maltose-binding protein is the periplasmic component of the ABC transporter responsible for the uptake of maltose/maltodextrins. The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. The crystal belonged to the primitive hexagonal space group P6(1)22, with unit-cell parameters a = 123.59, b = 123.59, c = 304.20 A, and contained two molecules in the asymetric unit. It diffracted to 2.24 A resolution.

  2. Daylight photodynamic therapy with MAL cream for large-scale photodamaged skin based on the concept of 'actinic field damage': recommendations of an international expert group.

    PubMed

    Philipp-Dormston, W G; Sanclemente, G; Torezan, L; Tretti Clementoni, M; Le Pillouer-Prost, A; Cartier, H; Szeimies, R M; Bjerring, P

    2016-01-01

    Conventional PDT (c-PDT) is a widely used and approved non-invasive treatment for actinic keratosis (AK). Recent clinical, histological and immunohistochemical observations have shown that c-PDT with methyl aminolevulinate (MAL) may also partially reverse the signs of photodamage. However, pain and the need for special light source equipment are limiting factors for its use, especially in the treatment of large areas. More recently, daylight PDT (DL-PDT) has been shown to be similar to c-PDT in the treatment of AK, nearly painless and more convenient to perform. To establish consensus on recommendations for the use of MAL DL-PDT in patients with large-scale photodamaged skin. The expert group was comprised of eight dermatologists. Consensus was developed based on the personal experience of the experts in c-PDT and DL-PDT, and results of an extensive literature review. MAL DL-PDT for large areas of photodamaged skin was evaluated and recommendations based on broad clinical experience were provided. As supported by evidence-based data from multicentre studies conducted in Australia and Europe, the authors defined the concept of 'actinic field damage' which refers to photodamage associated with actinic epidermal dysplasia, and provide comprehensive guidelines for the optimal use of DL-PDT in the treatment of actinic field damage. The authors concluded that MAL DL-PDT has a similar efficacy to c-PDT at 3-month (lesion complete response rate of 89% vs. 93% in the Australian study and 70% vs. 74% in the European study (95% C.I. = [-6.8;-0.3] and [-9.5;2.4] respectively) and 6-month follow-ups (97% maintenance of complete lesion response) in the treatment of AKs. The authors agree that DL-PDT is not only efficacious but also nearly pain-free and easy to perform, and therefore results in high patient acceptance especially for the treatment of areas of actinic field damage.

  3. 77 FR 21989 - Critical Infrastructure Private Sector Clearance Program Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... SECURITY Critical Infrastructure Private Sector Clearance Program Request AGENCY: National Protection and... information provided. SUPPLEMENTARY INFORMATION: The Critical Infrastructure Private Sector Clearance Program (PSCP) sponsors clearances for private sector partners who are responsible for critical...

  4. Multi-Sector Sustainability Browser (MSSB)

    EPA Pesticide Factsheets

    A browser which lets the user navigate through text and graphics and understand the interrelationship among four key sectors of a community crucial to sustainability: Land Use, Buildings and Infrastructure, Transportation, and Materials Management.

  5. Climate Leadership in the Financial Sector Webinar

    EPA Pesticide Factsheets

    Financial sector winners from the 2015 Climate Leadership Awards discuss best practices and challenges faced by their corporations based on their experience of attempting to reduce greenhouse gas emissions and address climate risk.

  6. Occupational health scenario of Indian informal sector

    PubMed Central

    NAG, Anjali; VYAS, Heer; NAG, Pranab

    2016-01-01

    Workers in the Indian informal sector are engaged with different occupations. These occupations involve varied work related hazards. These occupational hazards are a consequent risk to health. The study aimed to determine occupational health scenario in the Indian Informal sector. One thousand eleven hundred twenty two workers from five different occupations namely weaving (handloom and power loom), construction, transportation, tobacco processing and fish processing were assessed by interviewer administered health questionnaire. Workers suffered from musculo-skeletal complaints, respiratory health hazards, eye problems and skin related complaints. There was a high prevalence of self-reported occupational health problems in the selected sectors. The study finds that workers have occupational exposures to multiple hazards. The absence of protective guards aggrevate their health condition. The study attempts to draws an immediate attention on the existing health scenario of the Indian Informal sector. PMID:26903262

  7. Oil and Gas Extraction Sector (NAICS 211)

    EPA Pesticide Factsheets

    Environmental regulatory information for oil and gas extraction sectors, including oil and natural gas drilling. Includes information about NESHAPs for RICE and stationary combustion engines, and effluent guidelines for synthetic-based drilling fluids

  8. Automotive Sectors (NAICS 336, 4231, 8111)

    EPA Pesticide Factsheets

    Find regulatory, compliance, and enforcement information for environmental laws and regulations for the automotive sectors, which includes transportation equipment manufacturing, and establishments involved in repair and maintenance services for vehicles

  9. Ship and Boat Building Sector (NAICS 3336)

    EPA Pesticide Factsheets

    Find environmental regulatory and compliance information for the shipbuilding sector (NAICS 3336), including NESHAPs and air toxics regulations, nonroad engines and vehicles, managing used oil, and polluted runoff from marinas and boating areas.

  10. Market Report for the Industrial Sector, 2009

    SciTech Connect

    Sastri, Bhima; Brueske, Sabine; de los Reyes, Pamela; Jamison, Keith; Justiniano, Mauricio; Margolis, Nancy; Monfort, Joe; Raghunathan, Anand; Sabouni, Ridah

    2009-07-01

    This report provides an overview of trends in industrial-sector energy use. It focuses on some of the largest and most energy-intensive industrial subsectors and several emerging technologies that could transform key segments of industry.

  11. Pharmaceutical and Medicine Manufacturing Sector (NAICS 3254)

    EPA Pesticide Factsheets

    Find environmental regulatory and compliance information for the pharmaceutical manufacturing sector, including essential uses of CFCs, NESHAP for pharmaceutical production, effluent guidelines for wastewater and management of hazardous waste.

  12. Building recycling rates through the informal sector.

    PubMed

    Wilson, David C; Araba, Adebisi O; Chinwah, Kaine; Cheeseman, Christopher R

    2009-02-01

    Many developing country cities aspire to modern waste management systems, which are associated with relatively high recycling rates of clean, source separated materials. Most already have informal sector recycling systems, which are driven solely by the revenues derived from selling recovered materials, even though they are saving the formal sector money by reducing waste quantities. There is clear potential for 'win-win' co-operation between the formal and informal sectors, as providing support to the informal sector, to build recycling rates and to address some of the social issues could reduce the overall costs of waste management for the formal sector. This paper shows that recycling rates already achieved by the informal sector can be quite high, typically in the range from 20% to 50%; often up to half of this is in the form of clean, source separated materials collected directly from households and businesses by itinerant waste buyers. Four country case studies provide a number of lessons on how this solid foundation could be used to build high recycling rates of clean materials.

  13. Building recycling rates through the informal sector

    SciTech Connect

    Wilson, David C.; Araba, Adebisi O.; Chinwah, Kaine; Cheeseman, Christopher R.

    2009-02-15

    Many developing country cities aspire to modern waste management systems, which are associated with relatively high recycling rates of clean, source separated materials. Most already have informal sector recycling systems, which are driven solely by the revenues derived from selling recovered materials, even though they are saving the formal sector money by reducing waste quantities. There is clear potential for 'win-win' co-operation between the formal and informal sectors, as providing support to the informal sector, to build recycling rates and to address some of the social issues could reduce the overall costs of waste management for the formal sector. This paper shows that recycling rates already achieved by the informal sector can be quite high, typically in the range from 20% to 50%; often up to half of this is in the form of clean, source separated materials collected directly from households and businesses by itinerant waste buyers. Four country case studies provide a number of lessons on how this solid foundation could be used to build high recycling rates of clean materials.

  14. Cyclical absenteeism among private sector, public sector and self-employed workers.

    PubMed

    Pfeifer, Christian

    2013-03-01

    This research note analyzes differences in the number of absent working days and doctor visits and in their cyclicality between private sector, public sector and self-employed workers. For this purpose, I used large-scale German survey data for the years 1995 to 2007 to estimate random effects negative binomial (count data) models. The main findings are as follows. (i) Public sector workers have on average more absent working days than private sector and self-employed workers. Self-employed workers have fewer absent working days and doctor visits than dependent employed workers. (ii) The regional unemployment rate is on average negatively correlated with the number of absent working days among private and public sector workers as well as among self-employed men. The correlations between regional unemployment rate and doctor visits are only significantly negative among private sector workers.

  15. Discovering potential serological biomarker for chronic Hepatitis B Virus-related hepatocellular carcinoma in Chinese population by MAL-associated serum glycoproteomics analysis

    PubMed Central

    Liu, Tianhua; Liu, Denghe; Liu, Riqiang; Jiang, Hucong; Yan, Guoquan; Li, Wei; Sun, Lu; Zhang, Shu; Liu, Yinkun; Guo, Kun

    2017-01-01

    The accuracy of current biomarkers for the diagnosis of hepatocellular carcinoma (HCC), especially chronic Hepatitis B Virus (HBV)-related HCC, is limited. Recent progress in glycoproteomics has provided a novel platform for screening novel serological biomarkers of HCC. In this study, lectin affinity chromatography by Maackia amurensis lectin (MAL) and iTRAQ combined with mass spectrometric analysis were performed to enrich and identify the glycoprotein fractions in serum samples from HBV-related HCC patients and from healthy controls. Seventeen differential MAL-associated glycoproteins were identified. Among them, Galectin 3 binding protein (Gal-3BP) was selected for further evaluated by ELISA analysis and showed a high diagnostic potential of HBV-related HCC, with the AUC of 0.898 and a sensitivity, specificity and accuracy of 80.00%, 93.75% and 86.88%, respectively. Moreover, we constructed a predictive model through the combined use of serum Gal-3BP and Alpha Fetoprotein (AFP), which improved the sensitivity (from 87.5% to 95%), specificity (from 93.75% to 95%) and accuracy (from 90.63% to 95%) of diagnosing early HCC. These data suggested serum Gal-3BP level is a promising biomarker to identify HBV-related HCC and the combined use of serum Gal-3BP and AFP improves the diagnostic potential of HBV-HCC compared with AFP alone in current clinical practice. PMID:28079114

  16. Phase stability, elastic anisotropy and electronic structure of cubic MAl2 (M = Mg, Ca, Sr and Ba) Laves phases from first-principles calculations

    NASA Astrophysics Data System (ADS)

    Kong, Yuanyuan; Duan, Yonghua; Ma, Lishi; Li, Runyue

    2016-10-01

    By performing first-principles calculations within the generalized gradient approximation, the phase stability, elastic constant and anisotropy, and density of states of cubic C15-type MAl2 (M = Mg, Ca, Sr and Ba) Laves phases have been investigated. Optimized equilibrium lattice parameters and formation enthalpies agree well with the available experimental data. Elastic constants C ij have been evaluated, and these C15-type MAl2 Laves phases are mechanically stable due to the meeting of C ij to the mechanical stability criteria. Polycrystalline elastic moduli have been deduced from elastic constants by Voigt-Reuss-Hill approximation. Plastic properties were characterized via values of B/G, Poisson’s ratio ν and Cauchy pressure (C 12-C 44). The elastic anisotropy has been considered by several anisotropy indexes (A U , A Z , A shear and A comp), anisotropy of shear modulus, and 3D surface constructions of bulk and Young’s moduli. Additionally, the sound velocity anisotropy and Debye temperature were predicted. Finally, electronic structures were carried out to reveal the underlying phase stability mechanism of these Laves phases.

  17. Postpartum Depressive Symptoms Across Time and Place: Structural Invariance of the Self-Reporting Questionnaire Among Women from the International, Multi-Site MAL-ED Study

    PubMed Central

    Pendergast, Laura L.; Scharf, Rebecca J.; Rasmussen, Zeba A.; Seidman, Jessica C.; Schaefer, Barbara A.; Svensen, Erling; Tofail, Fahmida; Koshy, Beena; Kosek, Margaret; Rasheed, Muneera A.; Roshan, Reeba; Maphula, Angelina; Shrestha, Rita; Murray-Kolb, Laura E.

    2014-01-01

    Background The Self-Reporting Questionnaire (SRQ) is a screening instrument that has been shown to be an effective measure of depression in postpartum women and is widely used in developing nations. Methods The SRQ was administered to 2,028 mothers from eight nations at two time points: one and six months postpartum. All data were obtained from the Interactions of Malnutrition and Enteric Infections: Consequences for Child Health and Development (MAL-ED) study. The sample included women from MAL-ED sites in Bangladesh, Brazil, India, Nepal, Pakistan, Peru, South Africa, and Tanzania. This study examined three aspects of validity of SRQ scores including (a) structural validity, (b) cross-cultural invariance, and (c) invariance over time. Results A 16-item, one-factor structure with items reflecting somatic symptoms removed was deemed to be superior to the original structure in this postpartum population. Although differential item functioning (DIF) across sites was evident, the one-factor model was a good fit to the data from seven sites, and the structure was invariant across the one- and six-month time points. Limitations Findings are based on data from self-report scales. No information about the clinical status of the participants was available. Conclusions Overall, findings support the validity of a modified model of the SRQ among postpartum women. Somatic symptoms (e.g., headaches, not sleeping well) may not reflect internalizing problems in a postpartum population. Implications for researchers and practitioners are discussed. PMID:24981251

  18. Private sector joins family planning effort.

    PubMed

    1989-12-01

    Projects supported by the Directorate for Population (S&T/POP) of the U.S. Agency for International Development and aimed at increasing for-profit private sector involvement in providing family planning services and products are described. Making products commercially available through social-marketing partnerships with the commercial sector, USAID has saved $1.1 million in commodity costs from Brazil, Dominican Republic, Ecuador, Indonesia, and Peru. Active private sector involvement benefits companies, consumers, and donors through increased corporate profits, healthier employees, improved consumer access at lower cost, and the possibility of sustained family planning programs. Moreover, private, for-profit companies will be able to meet service demands over the next 20 years where traditional government and donor agency sources would fail. Using employee surveys and cost-benefit analyses to demonstrate expected financial and health benefits for businesses and work forces, S&T/POP's Technical Information on Population for the Private Sector (TIPPS) project encourages private companies in developing countries to invest in family planning and maternal/child health care for their employees. 36 companies in 9 countries have responded thus far, which examples provided from Peru and Zimbabwe. The Enterprise program's objectives are also to increase the involvement of for-profit companies in delivering family planning services, and to improve the efficiency and effectiveness of private volunteer organizations in providing services. Projects have been started with mines, factories, banks, insurance companies, and parastatals in 27 countries, with examples cited from Ghana and Indonesia. Finally, the Social Marketing for Change project (SOMARC) builds demand and distributes low-cost contraceptives through commercial channels especially to low-income audiences. Partnerships have been initiated with the private sector in 17 developing countries, with examples provided from

  19. Real-life practice study of the clinical outcome and cost-effectiveness of photodynamic therapy using methyl aminolevulinate (MAL-PDT) in the management of actinic keratosis and basal cell carcinoma.

    PubMed

    Annemans, Lieven; Caekelbergh, Karin; Roelandts, Rik; Boonen, Hugo; Leys, Christoph; Nikkels, Arjen F; van Den Haute, V; van Quickenborne, L; Verhaeghe, Evelien; Leroy, Bernard

    2008-01-01

    Clinical trials have shown that photodynamic therapy using methyl aminolevulinate (MAL-PDT) is an effective treatment for actinic keratosis (AK), and nodular and superficial basal cell carcinoma (nBCC and sBCC) unsuitable for other available therapies. Economic evaluation models have shown that it is a cost effective intervention as well. The objectives of this prospective, observational, one arm study were (i) to verify in a real-life practice study the results obtained in previous clinical trials with MAL-PDT in the treatment of AK, nBCC and sBCC; (ii) to calculate the real-life cost of treatment and validate predictions from an economic evaluation model. Patients with AK and/or BCC were selected according to Belgian reimbursement criteria for treatment with MAL-PDT. Clinical response, cosmetic outcome and tolerability were assessed. MAL-PDT cost was calculated and compared to published model cost data. Data were collected from 247 patients (117 AK, 130 BCC). A complete clinical response was obtained for 83% of AK (85/102) and BCC (97/116) patients. A good or excellent cosmetic outcome was obtained for 95% of AK patients and 93% of BCC patients. Tolerability was good: only 2 patients withdrew for adverse events. Clinical results were similar to previous studies. Total cost of care per patient was euro 381 for AK, euro 318 for nBCC, and euro 298 for sBCC. Total cost per lesion was euro 58 for AK (identical to model prediction), euro 316 for nBCC and euro 178 for sBCC (both within 20% of model prediction). The clinical results of MAL-PDT in this real-life practice study confirm those demonstrated in previous clinical trials. Costs calculated from this study confirm predicted cost-effectiveness in the original model for MAL-PDT in the management of AK and BCC.

  20. Nanotechnology in agri-food sector.

    PubMed

    Kumari, Avnesh; Yadav, Sudesh Kumar

    2014-01-01

    The emergence of nanotechnology developments using nanodevices/nanomaterials opens up potential novel applications in agriculture and food sector. Smart delivery systems, biosensors, and nanoarrays are being designed to solve the problems faced in agriculture sector. Similarly, food sector is also benefited through the use of smart biosensors, packaging materials, and nanonutraceuticals. Despite the great potential of nanotechnology in agri-food sector, people are ambiguous about use in food applications because of suspected potential health risks and environmental concerns. Nanoparticles, due to their unique characteristics, including small size, shape, high surface area, charge, chemical properties, solubility and degree of agglomeration can cross cell boundaries or pass directly from the lungs into the blood stream and ultimately reach to all of the organs in the body. This is the reason why they may pose higher risk than the same mass and material of larger particles. In this paper, we have made an attempt to give an overview of nanotechnology developments in agri-food sector, risks associated with nanomaterials and toxicity regulations for policy framework.

  1. Coupling the inflationary sector to matter

    NASA Astrophysics Data System (ADS)

    Kallosh, Renata; Linde, Andrei; Wrase, Timm

    2016-04-01

    We describe the coupling of matter fields to an inflationary sector of supergravity, the inflaton Φ and a stabilizer S, in models where the Kähler potential has a flat inflaton direction. Such models include, in particular, advanced versions of the hyperbolic α-attractor models with a flat inflaton direction Kähler potential, providing a good fit to the observational data. If the superpotential is at least quadratic in the matter fields U i , with restricted couplings to the inflaton sector, we prove that under certain conditions: i) The presence of the matter fields does not affect a successful inflationary evolution. ii) There are no tachyons in the matter sector during and after inflation. iii) The matter masses squared are higher than 3 H 2 during inflation. The simplest class of theories satisfying all required conditions is provided by models with a flat direction Kähler potential, and with the inflaton Φ and a stabilizer S belonging to a hidden sector, so that matter fields have no direct coupling to the inflationary sector in the Kähler potential and in the superpotential.

  2. [The creation of the informal sector in urban areas].

    PubMed

    Papayungan, M M

    1984-12-01

    The development of the informal sector of the economy in urban areas of Indonesia is analyzed. The author notes that this sector is dominated by high rates of migration from rural areas, limited employment opportunities for the unskilled in the modern sector, and a demand for low-priced services and products from the informal sector. (summary in ENG)

  3. Hospital expenses in a sector model.

    PubMed Central

    Friedman, B; Pliska, S R

    1985-01-01

    This review summarizes the capabilities and contributions of quantitative sector models for understanding trends in hospital expenses and the effects thereon of various public policies. After some brief historical notes on the use of analogous models in other policy areas, the general classes of national, partial, and narrow health sector models are introduced with special attention to method of validation and behavioral structure. Fourteen published models, described and critically reviewed with regard to these criteria, are assessed for their individual application to important policy and behavioral issues. Suggestions are offered for improvements and new initiatives in the use of sector models both in forecasting and in the study of procompetitive policies and reimbursement rule changes. PMID:3918960

  4. Strengthening health systems by health sector reforms

    PubMed Central

    Senkubuge, Flavia; Modisenyane, Moeketsi; Bishaw, Tewabech

    2014-01-01

    Background The rising burden of disease and weak health systems are being compounded by the persistent economic downturn, re-emerging diseases, and violent conflicts. There is a growing recognition that the global health agenda needs to shift from an emphasis on disease-specific approaches to strengthening of health systems, including dealing with social, environmental, and economic determinants through multisectoral responses. Methods A review and analysis of data on strengthening health sector reform and health systems was conducted. Attention was paid to the goal of health and interactions between health sector reforms and the functions of health systems. Further, we explored how these interactions contribute toward delivery of health services, equity, financial protection, and improved health. Findings Health sector reforms cannot be developed from a single global or regional policy formula. Any reform will depend on the country's history, values and culture, and the population's expectations. Some of the emerging ingredients that need to be explored are infusion of a health systems agenda; development of a comprehensive policy package for health sector reforms; improving alignment of planning and coordination; use of reliable data; engaging ‘street level’ policy implementers; strengthening governance and leadership; and allowing a holistic and developmental approach to reforms. Conclusions The process of reform needs a fundamental rather than merely an incremental and evolutionary change. Without radical structural and systemic changes, existing governance structures and management systems will continue to fail to address the existing health problems. PMID:24560261

  5. Implementing Montessori Education in the Public Sector.

    ERIC Educational Resources Information Center

    Kahn, David, Ed.

    This book on implementing Montessori education in the public sector begins with a historical and social overview that reveals the usefulness of Montessori pedagogy as a means of national public school reform. The second chapter discusses equipment needed for Montessori schools, the scope and sequence of curriculum used, and minimal expectations…

  6. Parallel Education and Defining the Fourth Sector.

    ERIC Educational Resources Information Center

    Chessell, Diana

    1996-01-01

    Parallel to the primary, secondary, postsecondary, and adult/community education sectors is education not associated with formal programs--learning in arts and cultural sites. The emergence of cultural and educational tourism is an opportunity for adult/community education to define itself by extending lifelong learning opportunities into parallel…

  7. Marketing in the Australian Higher Education Sector

    ERIC Educational Resources Information Center

    Favaloro, Chrissa

    2015-01-01

    This article examines domestic marketing in the Australian higher education sector, specifically, the marketing investment patterns of universities and their levels of student growth as a return on marketing investment. Marketing expenditure by universities has risen 23 per cent in the five years to 2013, with several institutions allocating in…

  8. Multi-sectoral interventions for healthy growth.

    PubMed

    Casanovas, Ma del Carmen; Lutter, Chessa K; Mangasaryan, Nune; Mwadime, Robert; Hajeebhoy, Nemat; Aguilar, Ana Maria; Kopp, Ciro; Rico, Luis; Ibiett, Gonzalo; Andia, Doris; Onyango, Adelheid W

    2013-09-01

    The risk of stunted growth and development is affected by the context in which a child is born and grows. This includes such interdependent influences as the political economy, health and health care, education, society and culture, agriculture and food systems, water and sanitation, and the environment. Here, we briefly review how factors linked with the key sectors can contribute to healthy growth and reduced childhood stunting. Emphasis is placed on the role of agriculture/food security, especially family farming; education, particularly of girls and women; water, sanitation, and hygiene and their integration in stunting reduction strategies; social protection including cash transfers, bearing in mind that success in this regard is linked to reducing the gap between rich and poor; economic investment in stunting reduction including the work with the for-profit commercial sector balancing risks linked to marketing foods that can displace affordable and more sustainable alternatives; health with emphasis on implementing comprehensive and effective health care interventions and building the capacity of health care providers. We complete the review with examples of national and subnational multi-sectoral interventions that illustrate how critical it is for sectors to work together to reduce stunting.

  9. Rabi multi-sector reservoir simulation model

    SciTech Connect

    Bruijnzeels, C.; O`Halloran, C.

    1995-12-31

    To ensure optimum ultimate recovery of the 46 meter thick oil rim of the Rabi Field in Gabon, a full field simulation model was required. Due to it`s size and complexity, with local cusping, coning and geological circumstances dominating individual well behavior, a single full field model would be too large for existing hardware. A method was developed to simulate the full field with 5 separate sector models, whilst allowing the development in one sector model to have an effect on the boundary conditions of another sector. In this manner, the 13 x 4.5 km field could be simulated with a horizontal well spacing down to 175 meter. This paper focuses on the method used to attach single 3-phase tank cells to a sector simulation grid in order to represent non-simulated parts of the field. It also describes the history matching methodology and how to run a multisector model in forecasting mode. This method can be used for any reservoir, where size and complexity require large reservoir simulation models that normally could not be modeled within the constraints of available computer facilities. Detailed studies can be conducted on specific parts of a field, whilst allowing for dynamic flow and pressure effects caused by the rest of the field.

  10. Indigenous Students in the Tertiary Education Sector

    ERIC Educational Resources Information Center

    Bandias, Susan; Fuller, Don; Larkin, Steven

    2014-01-01

    Important recent objectives of indigenous education policy in Australia have been aimed at redressing indigenous economic and social disadvantage through increasing student retention, progression and completion rates in both compulsory and post-compulsory education. The two sectors of the tertiary education system, vocational education and…

  11. Benchmarking for the Learning and Skills Sector.

    ERIC Educational Resources Information Center

    Owen, Jane

    This document is designed to introduce practitioners in the United Kingdom's learning and skills sector to the principles and practice of benchmarking. The first section defines benchmarking and differentiates metric, diagnostic, and process benchmarking. The remainder of the booklet details the following steps of the benchmarking process: (1) get…

  12. Quality Assurance in Ontario's Postsecondary Education Sector

    ERIC Educational Resources Information Center

    Klassen, Tim

    2012-01-01

    It is generally accepted that Canadian postsecondary education enjoys an international reputation for quality. However, Canada does not have an accepted, national framework to understand, measure, or clearly define the actual quality of the postsecondary education sector. In this, Canada is seen as unique when compared with other developed…

  13. [Organization and technology in the catering sector].

    PubMed

    Tinarelli, Arnaldo

    2014-01-01

    The catering industry is a service characterized by a contract between customer and supplier. In institutional catering industry, the customer is represented by public administration; in private catering industry, the customer is represented by privates. The annual catering trades size is about 6.74 billions of euros, equally distributed between health sector (hospitals, nursing homes), school sector and business sector (ivorkplace food service), with the participation of nearly 1.200 firms and 70.000 workers. Major services include off-premises catering (food prepared away from the location where it's served) and on-premises catering (meals prepared and served at the same place). Several tools and machineries are used during both warehousing and food refrigerating operations, and during preparation, cooking, packaging and transport of meals. In this sector, injuries, rarely resulting serious or deadly, show a downward trend in the last years. On the contrary, the number of occupational diseases shows an upward trend. About the near future, the firms should become global outsourcer, able to provide other services as cleaning, transport and maintenance. In addition, they should invest in innovation: from tools and machineries technology to work organization; from factory lay-out to safely and health in the workplaces.

  14. Competitiveness measurement system in the advertising sector.

    PubMed

    Poveda-Bautista, Rocío; García-Melón, Mónica; Baptista, Doris C

    2013-01-01

    In this paper a new approach to find indicators that can be used to measure companies' competitiveness and performance in an efficient and reliable way is presented. The aim is to assist managers of companies within a specific industrial sector by providing information about their relative position in the market so as to define better action plans that may improve the company's performance. The approach combines the use of the Analytic Network Process, a multicriteria decision method, with the Balanced Scorecard. It allows the definition of a number of competitiveness indicators based on the performance and setting of the advertising sector. In this way it is possible to obtain a Competitiveness Index that allows a company to know its relative position with respect to other companies in the sector, and establish a ranking of the companies ordered by their competitiveness level. A case study in the advertising industry of Venezuela is provided. Results show that improvement plans for the agencies analyzed should promote creativity, innovation and the use of new technologies, as a particular form of innovation. These factors were considered to be the most relevant indicators in the advertising sector. The participating experts agreed that the methodology is useful and an improvement over current competitiveness assessment methods.

  15. Public Sector Bargaining and Strikes. Second Edition.

    ERIC Educational Resources Information Center

    Public Service Research Council, Vienna, VA.

    It is the opinion of the authors of this position paper that collective bargaining in the public sector causes an increase in strikes and employee unrest, resulting in a diminution of public services. The authors assert that public employee collective bargaining means giving unions the power to control government through intimidation of the…

  16. Educational Assistance to the Urban Informal Sector.

    ERIC Educational Resources Information Center

    Oxenham, John

    1984-01-01

    The urban informal sector are the adolescents and adults of cities in developing countries who have had little or no education and expend much inventiveness and energy to avoid starvation, while working in activities such as pedlar or shoeshiner. What educational assistance could and should be provided for them is discussed. (RM)

  17. Yukawa sector in SO(10) (Abstract)

    SciTech Connect

    Melfo, A.

    2007-10-03

    Grand Unified Theories based on the group SO(10) generically provide interesting and testable relations between the charged fermions and neutrino sector masses and mixings. In the light of the recent neutrino data, we reexamine these relations both in supersymmetric and non-supersymmetric models, and give a brief review of their present status.

  18. Developing a Defense Sector Assessment Rating Tool

    DTIC Science & Technology

    2010-01-01

    kms/details.cfm?ord279=title&q279=Public+Oversight&lng=en&id=95396 & nav1 = 5 “Conducting an Assessment,” in Coleen Rausch, ed., Combating Serious Crimes... 5 Section One: Characteristics of the Defense Sector... 5 Section Two: Assessment of Defense Institutions and Processes

  19. 50 CFR 648.87 - Sector allocation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Sector allocation. 648.87 Section 648.87 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES Management Measures for the NE Multispecies and Monkfish Fisheries §...

  20. [Eco-efficiency of Jiaozuo industry sectors].

    PubMed

    Du, Yan-chun; Jiang, Pan; Mao, Jian-su; Xu, Lin-yu

    2011-05-01

    Jiaozuo city was taken as a representative industry city and its industry energy consumption and industry emissions such as wastewater,solid waste, SO2, dust and so on were selected as corresponding environmental loads. The contribution rate to the environmental loads and eco-efficiencies of Jiaozuo industry sectors were analyzed quantitatively. The results show that, the industry sector with the highest energy eco-efficiency is Mining and Processing of Ferrous Metal Ores (FMM), 43.19 x 10(4) yuan x tce(-1), and its contribution rate is 0.003%; the one with the highest wastewater-related eco-efficiency is Manufacture of Transport Equipment (TRM), 3.58 x 10(4) yuan x t(-1), and its contribution rate is 0.0001%; the one with the highest solid waste-related eco-efficiency is Manufacture of Special Purpose Machinery( SMM), 323.22 x 10(4) yuan x t(-1), and its contribution rate is 0.005%; the one with the highest SO2 emission-related eco-efficiency is Manufacture of Special Purpose Machinery (SMM), 19.74 x 10(4) yuan x kg(-1), and its contribution rate is 0.0001%; the one with the highest dust emission-related eco-efficiency is Manufacture of Rubber (RUM), 6.75 x 10(4) yuan x kg(-1), and its contribution rate is 0.001%. It can be seen that the industry sector with high value of eco-efficiency always contributes less to its environmental load, which results that the industry sectors with high eco-efficiencies only play a weak role in leading the overall industry eco-efficiency. A succinct distance index (SDI) was proposed to estimate the differences between Jiaozuo and China average for their eco-efficiency of every industrial sector. The values of SDI range from -1 to 63.45, and the absolute value of SDI with positive value is much greater than that with negative value, which indicates that the values of eco-efficiencies for the advanced industry sectors of Jiaozuo city are much higher than those for China's industry sectors average.

  1. Site-related near-infrared luminescence in MAl{sub 12}O{sub 19} (M = Ca, Sr, Ba):Fe{sup 3+} phosphors

    SciTech Connect

    Li, Y.J.; Ma, Y.Y.; Ye, S.; Hu, G.P.; Zhang, Q.Y.

    2014-03-01

    Graphical abstract: - Highlights: • Intense 700–850 nm NIR emissions in MAl{sub 12}O{sub 19} (M = Ca, Sr, Ba):1%Fe{sup 3+} has been obtained. • The NIR emissions can be ascribed to the octahedral Fe{sup 3+} sites. • The site symmetry of Fe{sup 3+} in CA{sub 6} and SA{sub 6} may be lower than that in BA{sub 6}. • The phosphors may be potentially applied in the high-resolution bioimaging. - Abstract: Intense and broad near-infrared (NIR) photoluminescence (PL) peaks locating at 777, 808 and 810 nm is observed for BaAl{sub 12}O{sub 19} (BA{sub 6}):1%Fe{sup 3+}, CaAl{sub 12}O{sub 19} (CA{sub 6}):1%Fe{sup 3+} and SrAl{sub 12}O{sub 19} (SA{sub 6}):1%Fe{sup 3+}, respectively. Electron paramagnetic resonance (EPR) spectra show that Fe{sup 3+} ions substitute for the different types of Al{sup 3+} sites simultaneously. Meanwhile, the luminescence of Fe{sup 3+} in MAl{sub 12}O{sub 19} (M = Ca, Sr and Ba) are ascribed to octahedral Fe{sup 3+}. In addition, the site symmetry of Fe{sup 3+} in CA{sub 6}/SA{sub 6} is lower compared with BA{sub 6}, deduced from the photoluminescence excitation (PLE), EPR and Fourier-transform infrared (FT-IR) spectra. These phosphors can be considered as good candidates for the applications in the field of high-resolution bioimaging.

  2. China's industrial sector in an international context

    SciTech Connect

    Price, Lynn; Worrell, Ernst; Martin, Nathan; Lehman, Bryan; Sinton, Jonathan

    2000-05-01

    The industrial sector accounts for 40% of global energy use. In 1995, developing countries used an estimated 48 EJ for industrial production, over one-third of world total industrial primary energy use (Price et al., 1998). Industrial output and energy use in developing countries is dominated by China, India, and Brazil. China alone accounts for about 30 EJ (National Bureau of Statistics, 1999), or about 23% of world industrial energy use. China's industrial sector is extremely energy-intensive and accounted for almost 75% of the country's total energy use in 1997. Industrial energy use in China grew an average of 6.6% per year, from 14 EJ in 1985 to 30 EJ in 1997 (Sinton et al., 1996; National Bureau of Statistics, 1999). This growth is more than three times faster than the average growth that took place in the world during the past two decades. The industrial sector can be divided into light and heavy industry, reflecting the relative energy-intensity of the manufacturing processes. In China, about 80% of the energy used in the industrial sector is consumed by heavy industry. Of this, the largest energy-consuming industries are chemicals, ferrous metals, and building materials (Sinton et al., 1996). This paper presents the results of international comparisons of production levels and energy use in six energy-intensive subsectors: iron and steel, aluminum, cement, petroleum refining, ammonia, and ethylene. The sectoral analysis results indicate that energy requirements to produce a unit of raw material in China are often higher than industrialized countries for most of the products analyzed in this paper, reflecting a significant potential to continue to improve energy efficiency in heavy industry.

  3. Universal Industrial Solution and Industrial Sectors Module for Pulp and Paper Sector

    EPA Science Inventory

    Increased concerns over air pollution and its detrimental effects on health have called for more stringent emission reduction strategies in the industrial sector. However, stringent regulatory policies can potentially adversely affect domestic and international trade. Therefore E...

  4. Supersymmetric extended string field theory in NSn sector and NSn - 1-R sector

    NASA Astrophysics Data System (ADS)

    Asano, Masako; Kato, Mitsuhiro

    2016-09-01

    We construct a class of quadratic gauge invariant actions for extended string fields defined on the tensor product of open superstring state space for multiple open string Neveu-Schwarz (NS) sectors with or without one Ramond (R) sector. The basic idea is the same as for the bosonic extended string field theory developed by the authors [1]. The theory for NSn sector and NS n - 1-R sector contains general n-th rank tensor fields and (n - 1)-th rank spinor-tensor fields in the massless spectrum respectively. In principle, consistent gauge invariant actions for any generic type of 10-dimensional massive or massless tensor or spinor-tensor fields can be extracted from the theory. We discuss some simple examples of bosonic and fermionic massless actions.

  5. Environmental performance policy indicators for the public sector: the case of the defence sector.

    PubMed

    Ramos, Tomás B; Alves, Inês; Subtil, Rui; Joanaz de Melo, João

    2007-03-01

    The development of environmental performance policy indicators for public services, and in particular for the defence sector, is an emerging issue. Despite a number of recent initiatives there has been little work done in this area, since the other sectors usually focused on are agriculture, transport, industry, tourism and energy. This type of tool can be an important component for environmental performance evaluation at policy level, when integrated in the general performance assessment system of public missions and activities. The main objective of this research was to develop environmental performance policy indicators for the public sector, specifically applied to the defence sector. Previous research included an assessment of the environmental profile, through the evaluation of how environmental management practices have been adopted in this sector and an assessment of environmental aspects and impacts. This paper builds upon that previous research, developing an indicator framework--SEPI--supported by the selection and construction of environmental performance indicators. Another aim is to discuss how the current environmental indicator framework can be integrated into overall performance management. The Portuguese defence sector is presented and the usefulness of this methodology demonstrated. Feasibility and relevancy criteria are applied to evaluate the set of indicators proposed, allowing indicators to be scored and indicators for the policy level to be obtained.

  6. Benefits Assessment of Algorithmically Combining Generic High Altitude Airspace Sectors

    NASA Technical Reports Server (NTRS)

    Bloem, Michael; Gupta, Pramod; Lai, Chok Fung; Kopardekar, Parimal

    2009-01-01

    In today's air traffic control operations, sectors that have traffic demand below capacity are combined so that fewer controller teams are required to manage air traffic. Controllers in current operations are certified to control a group of six to eight sectors, known as an area of specialization. Sector combinations are restricted to occur within areas of specialization. Since there are few sector combination possibilities in each area of specialization, human supervisors can effectively make sector combination decisions. In the future, automation and procedures will allow any appropriately trained controller to control any of a large set of generic sectors. The primary benefit of this will be increased controller staffing flexibility. Generic sectors will also allow more options for combining sectors, making sector combination decisions difficult for human supervisors. A sector-combining algorithm can assist supervisors as they make generic sector combination decisions. A heuristic algorithm for combining under-utilized air space sectors to conserve air traffic control resources has been described and analyzed. Analysis of the algorithm and comparisons with operational sector combinations indicate that this algorithm could more efficiently utilize air traffic control resources than current sector combinations. This paper investigates the benefits of using the sector-combining algorithm proposed in previous research to combine high altitude generic airspace sectors. Simulations are conducted in which all the high altitude sectors in a center are allowed to combine, as will be possible in generic high altitude airspace. Furthermore, the algorithm is adjusted to use a version of the simplified dynamic density (SDD) workload metric that has been modified to account for workload reductions due to automatic handoffs and Automatic Dependent Surveillance Broadcast (ADS-B). This modified metric is referred to here as future simplified dynamic density (FSDD). Finally

  7. Co-operation of π⋯π, Cu(II)⋯π, carbonyl⋯π and hydrogen-bonding forces leading to the formation of water cluster mimics observed in the reassessed crystal structure of [Cu(mal)(phen)(H 2O)]2·3H 2O (H 2mal = malonic acid, phen = 1,10-phenanthroline)

    NASA Astrophysics Data System (ADS)

    Choudhury, Somnath Ray; Lee, Hon Man; Hsiao, Tsun-Hung; Colacio, Enrique; Jana, Atish Dipankar; Mukhopadhyay, Subrata

    2010-04-01

    A copper(II) malonate complex with formula [Cu(mal)(phen)(H 2O)] 2·3H 2O ( 1) [H 2mal = malonic acid, phen = 1,10-phenanthroline] has been synthesized and its crystal structure has been re-determined with an improved R value (the compound 1 was originally synthesized and crystallographically characterized by Kwik et al. with R = 0.047, see: J. Chem. Soc. Dalton Trans. (1986) 2529) with the water hydrogen atom positions located. This has led to the revelation that the water molecules organize around the carboxylate group of the malonate ligand forming tetramer, hexamer and octameric water cluster mimics. These cooperative hydrogen-bonding forces and various π-forces (π⋯π, Cu(II)⋯π, carbonyl⋯π) involving 1,10-phenanthroline aromatic rings determine the overall packing of the molecular units in the unit cell. There exists two identical monomers in the asymmetric unit with Z// = 2. TG measurements reveal the loss of water molecules that are all released at 120 °C. The water sorption/desorption process is reversible as supported by FTIR spectroscopic and XRPD studies.

  8. Top partner probes of extended Higgs sectors

    NASA Astrophysics Data System (ADS)

    Kearney, John; Pierce, Aaron; Thaler, Jesse

    2013-08-01

    Natural theories of the weak scale often include fermionic partners of the top quark. If the electroweak symmetry breaking sector contains scalars beyond a single Higgs doublet, then top partners can have sizable branching ratios to these extended Higgs sector states. In fact, top partner decays may provide the most promising discovery mode for such scalars, especially given the large backgrounds to direct and associated production. In this paper, we present a search strategy for top partner decays to a charged Higgs boson and a bottom quark, focusing on the case where the charged Higgs dominantly decays to third-generation quarks to yield a multi- b final state. We also discuss ways to extend this search to exotic neutral scalars decaying to bottom quark pairs.

  9. Advanced metering techniques in the federal sector

    SciTech Connect

    Szydlowski, R.F.; Chvala, W.D. Jr.; Halverson, M.A.

    1994-12-01

    The lack of utility metering in the federal sector has hampered introduction of direct billing of individual activities at most military installations. Direct billing will produce accountability for the amount of energy used and is a positive step toward self-directed energy conservation. For many installations, automatic meter reading (AMR) is a cost-effective way to increase the number of meters while reducing labor requirements and providing energy conservation analysis capabilities. The communications technology used by some of the AMR systems provides other demand-side management (DSM) capabilities. This paper summarizes the characteristics and relative merits of several AMR/DSM technologies that may be appropriate for the federal sector. A case study of an AMR system being installed at Fort Irwin, California, describes a cost-effective two-way radio communication system used for meter reading and load control.

  10. Approximate flavor symmetries in the lepton sector

    SciTech Connect

    Rasin, A. ); Silva, J.P. )

    1994-01-01

    Approximate flavor symmetries in the quark sector have been used as a handle on physics beyond the standard model. Because of the great interest in neutrino masses and mixings and the wealth of existing and proposed neutrino experiments it is important to extend this analysis to the leptonic sector. We show that in the seesaw mechanism the neutrino masses and mixing angles do not depend on the details of the right-handed neutrino flavor symmetry breaking, and are related by a simple formula. We propose several [ital Ansa]$[ital uml]---[ital tze] which relate different flavor symmetry-breaking parameters and find that the MSW solution to the solar neutrino problem is always easily fit. Further, the [nu][sub [mu]-][nu][sub [tau

  11. Fine-scale characteristics of interplanetary sector

    NASA Technical Reports Server (NTRS)

    Behannon, K. W.; Neubauer, F. M.; Barnstoff, H.

    1980-01-01

    The structure of the interplanetary sector boundaries observed by Helios 1 within sector transition regions was studied. Such regions consist of intermediate (nonspiral) average field orientations in some cases, as well as a number of large angle directional discontinuities (DD's) on the fine scale (time scales 1 hour). Such DD's are found to be more similar to tangential than rotational discontinuities, to be oriented on average more nearly perpendicular than parallel to the ecliptic plane to be accompanied usually by a large dip ( 80%) in B and, with a most probable thickness of 3 x 10 to the 4th power km, significantly thicker previously studied. It is hypothesized that the observed structures represent multiple traversals of the global heliospheric current sheet due to local fluctuations in the position of the sheet. There is evidence that such fluctuations are sometimes produced by wavelike motions or surface corrugations of scale length 0.05 - 0.1 AU superimposed on the large scale structure.

  12. Muon dynamics in a toroidal sector magnet

    SciTech Connect

    Gallardo, J.C.; Fernow, R.C.; Palmer, R.B.

    1998-01-01

    The present scenario for the cooling channel in a high brightness muon collider calls for a quasi-continuous solenoidal focusing channel. The beam line consists of a periodic array of hydrogen absorbers immersed in a solenoid with alternating focusing field and rf linacs at the zero field points. Solenoids and toroidal sectors have a natural place in muon collider design given the large emittance of the beam and consequently, the large transverse momentum of the initial pion beam or the decay muon beam. Bent solenoids as shown were studied for use at the front end of the machine, as part of the capture channel and more recently as part of a diagnostic setup to measure the position and momentum of muons. The authors present a Hamiltonian formulation of muon dynamics in toroidal sector solenoids (bent solenoid).

  13. Obstacles to Private Sector Activities in Africa,

    DTIC Science & Technology

    1983-01-01

    Finance Corporation (IFC), a World Bank affiliate, has declared its intention to step up its programs to assist the private sector in Africa. Many...and much of it is financed by I the rue Monsieur [the aid Ministry]. In many ways, therefore, France’s "progressive" approach to North-South relations...and the BCEAO together provide a unique and efficient financial system that offers external financing , French-style banking practices, and guarantees

  14. Learning from Transforming the Commercial Sector

    DTIC Science & Technology

    2002-01-01

    that large-scale institutional transformation is indeed ongoing. Several emerging phenomena characterize this trend. Intellectual Capital In the...importance and the new source of wealth is intellectual capital . This il- luminates an underlying shift in as- sumptions: critical assets of an organi- zation...the private sector that base their operating as- sumptions on intellectual capital . Their structures and practices differ from traditional approaches

  15. Experimental Searches for Dark Sector Phenomena

    NASA Astrophysics Data System (ADS)

    Alexander, Jim

    2017-01-01

    We summarize the state of experimental searches for Dark Sector dark matter, focussing on current and planned experiments that look for evidence of dark photon production. The accessible dark photon masses range from about 1 MeV to about 1 GeV, cover several orders of magnitude in the dimensionless coupling constant to normal matter. Experiments include fixed target and collider experiments, seeking inclusive or exclusive final state signatures, produced from either leptonic and hadronic initial states.

  16. Management by missions in the healthcare sector.

    PubMed

    Fonseca Pires, J; Rey, C; Más-Machuca, M; Bastons, M

    2016-01-01

    This article discusses the importance of the mission statement in the healthcare sector. It's also argued that only formal declaration of the mission it's insufficient to the appropriate professional coordination of doctors, nurses and managers. It's proposed a systematic approach to facilitate the introduction of the mission within the systems of the organization, what is called "Management by missions." It promotes horizontal and vertical integration between doctors, nurses and managers. Criteria that ensure this integration are specified.

  17. 77 FR 44641 - Critical Infrastructure Private Sector Clearance Program Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... SECURITY Critical Infrastructure Private Sector Clearance Program Request AGENCY: National Protection and... comments concerning Reinstatement, with change, of a previously approved ICR for the Critical... sector partners who are responsible for critical infrastructure protection but would not otherwise...

  18. 76 FR 57723 - Electricity Sector Cybersecurity Risk Management Process Guideline

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... Electricity Sector Cybersecurity Risk Management Process Guideline AGENCY: Department of Energy. ACTION... to publish the Electricity Sector Cybersecurity Risk Management Process Guideline. The guideline describes a risk management process that is targeted to the specific needs of electricity...

  19. Attribution of climate forcing to economic sectors.

    PubMed

    Unger, Nadine; Bond, Tami C; Wang, James S; Koch, Dorothy M; Menon, Surabi; Shindell, Drew T; Bauer, Susanne

    2010-02-23

    A much-cited bar chart provided by the Intergovernmental Panel on Climate Change displays the climate impact, as expressed by radiative forcing in watts per meter squared, of individual chemical species. The organization of the chart reflects the history of atmospheric chemistry, in which investigators typically focused on a single species of interest. However, changes in pollutant emissions and concentrations are a symptom, not a cause, of the primary driver of anthropogenic climate change: human activity. In this paper, we suggest organizing the bar chart according to drivers of change-that is, by economic sector. Climate impacts of tropospheric ozone, fine aerosols, aerosol-cloud interactions, methane, and long-lived greenhouse gases are considered. We quantify the future evolution of the total radiative forcing due to perpetual constant year 2000 emissions by sector, most relevant for the development of climate policy now, and focus on two specific time points, near-term at 2020 and long-term at 2100. Because sector profiles differ greatly, this approach fosters the development of smart climate policy and is useful to identify effective opportunities for rapid mitigation of anthropogenic radiative forcing.

  20. Decentralising the health sector: issues in Brazil.

    PubMed

    Collins, C; Araujo, J; Barbosa, J

    2000-06-01

    The health sector in Brazil has undergone important changes, particularly with the development of the Unified Health System (SUS). Decentralisation is an important principle of SUS and advances have been made in transferring responsibilities and resources to the local government units, known as municipios. This article describes the changes introduced, focusing on the system of municipio classification and the funding mechanisms introduced through the basic operating rule (BOR) of 1996. The paper then moves on to analysing three key issues of decentralisation in Brazil that are related to the policy process, the system of decentralisation and the output of decentralisation. Firstly, the formal process by which decisions on health sector reform are made is discussed with particular attention being paid to the negotiated and relatively open policy space. Secondly, the role of the states is discussed within the decentralised system. Thirdly, the impact of decentralisation on equity is discussed with particular reference to the resourcing of the Municipal Health Funds. The article concludes by emphasising the political nature of health sector decentralisation and the need to develop the conditions for effectiveness in decentralisation programmes.

  1. Attribution of climate forcing to economic sectors

    PubMed Central

    Unger, Nadine; Bond, Tami C.; Wang, James S.; Koch, Dorothy M.; Menon, Surabi; Shindell, Drew T.; Bauer, Susanne

    2010-01-01

    A much-cited bar chart provided by the Intergovernmental Panel on Climate Change displays the climate impact, as expressed by radiative forcing in watts per meter squared, of individual chemical species. The organization of the chart reflects the history of atmospheric chemistry, in which investigators typically focused on a single species of interest. However, changes in pollutant emissions and concentrations are a symptom, not a cause, of the primary driver of anthropogenic climate change: human activity. In this paper, we suggest organizing the bar chart according to drivers of change—that is, by economic sector. Climate impacts of tropospheric ozone, fine aerosols, aerosol-cloud interactions, methane, and long-lived greenhouse gases are considered. We quantify the future evolution of the total radiative forcing due to perpetual constant year 2000 emissions by sector, most relevant for the development of climate policy now, and focus on two specific time points, near-term at 2020 and long-term at 2100. Because sector profiles differ greatly, this approach fosters the development of smart climate policy and is useful to identify effective opportunities for rapid mitigation of anthropogenic radiative forcing. PMID:20133724

  2. HSCT Sector Combustor Evaluations for Demonstration Engine

    NASA Technical Reports Server (NTRS)

    Greenfield, Stuart; Heberling, Paul; Kastl, John; Matulaitis, John; Huff, Cynthia

    2004-01-01

    In LET Task 10, critical development issues of the HSCT lean-burn low emissions combustor were addressed with a range of engineering tools. Laser diagnostics and CFD analysis were applied to develop a clearer understanding of the fuel-air premixing process and premixed combustion. Subcomponent tests evaluated the emissions and operability performance of the fuel-air premixers. Sector combustor tests evaluated the performance of the integrated combustor system. A 3-cup sector was designed and procured for laser diagnostics studies at NASA Glenn. The results of these efforts supported the earlier selection of the Cyclone Swirler as the pilot stage premixer and the IMFH (Integrated Mixer Flame Holder) tube as the main stage premixer of the LPP combustor. In the combustor system preliminary design subtask, initial efforts to transform the sector combustor design into a practical subscale engine combustor met with significant challenges. Concerns about the durability of a stepped combustor dome and the need for a removable fuel injection system resulted in the invention and refinement of the MRA (Multistage Radial Axial) combustor system in 1994. The MRA combustor was selected for the HSR Phase II LPP subscale combustor testing in the CPC Program.

  3. Abnormal economics in the health sector.

    PubMed

    Hsaio, W C

    1995-01-01

    The implosion of centrally-planned economies has led to a widespread and uncritical belief that a free market is the best mechanism for structuring the economic and social sectors. Many international agencies have pushed this belief on the developing nations. This paper offers a critical analysis of the effectiveness of using free market principles to structure the health sector. We try to answer two questions: in what spheres can the market operate freely? In what spheres is government action required? According to economic theory, the market is only appropriate for producing and distributing private goods. This study analyzed health care and subdivides it into three categories (public, merit, and private goods) to clarify where the market has a legitimate role. Next, we analyze two of the five markets in the health sector--financing and delivery--and assess the respective roles of the market and government Competitive markets have certain prerequisites. We identify the major market failures by evaluating where these conditions are not satisfied. Next, we draw on international experience to ascertain the seriousness of those failures and the capacity of government action to correct them. Lessons are drawn for developing nations about the appropriateness of market strategies to finance and deliver health care.

  4. Dark matter freeze-out in a nonrelativistic sector

    NASA Astrophysics Data System (ADS)

    Pappadopulo, Duccio; Ruderman, Joshua T.; Trevisan, Gabriele

    2016-08-01

    A thermally decoupled hidden sector of particles, with a mass gap, generically enters a phase of cannibalism in the early Universe. The Standard Model sector becomes exponentially colder than the hidden sector. We propose the cannibal dark matter framework, where dark matter resides in a cannibalizing sector with a relic density set by 2-to-2 annihilations. Observable signals of cannibal dark matter include a boosted rate for indirect detection, new relativistic degrees of freedom, and warm dark matter.

  5. New Technologies to Assist Training in Hospitality Sector

    ERIC Educational Resources Information Center

    Balta, Sabah

    2007-01-01

    Hospitality sector needs new technological training tools, which can assist to improve sector employees' skills and services quality. The sector might be more interactive when these technological training tools used on the job-training program. This study addresses to issue of illumination of new technologic tools that enforce training in which…

  6. 22 CFR 139.8 - Target economic sectors.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Target economic sectors. 139.8 Section 139.8... § 139.8 Target economic sectors. Job/Training under the IPPCTP will be authorized for preferred economic... authorized to approve different employers in different economic sectors....

  7. Elements of a Knowledge Management Guide for Public Sector Organizations

    ERIC Educational Resources Information Center

    Harris, Mark Cameron

    2013-01-01

    This study explored the factors that are critical to the success of public (government) sector knowledge management initiatives and the lessons from private sector knowledge management and organizational learning that apply in the public sector. The goal was to create a concise guide, based on research-validated success factors, to aid government…

  8. 22 CFR 139.8 - Target economic sectors.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Target economic sectors. 139.8 Section 139.8... § 139.8 Target economic sectors. Job/Training under the IPPCTP will be authorized for preferred economic... authorized to approve different employers in different economic sectors....

  9. 22 CFR 139.8 - Target economic sectors.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Target economic sectors. 139.8 Section 139.8... § 139.8 Target economic sectors. Job/Training under the IPPCTP will be authorized for preferred economic... authorized to approve different employers in different economic sectors....

  10. 22 CFR 139.8 - Target economic sectors.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Target economic sectors. 139.8 Section 139.8... § 139.8 Target economic sectors. Job/Training under the IPPCTP will be authorized for preferred economic... authorized to approve different employers in different economic sectors....

  11. 22 CFR 139.8 - Target economic sectors.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Target economic sectors. 139.8 Section 139.8... § 139.8 Target economic sectors. Job/Training under the IPPCTP will be authorized for preferred economic... authorized to approve different employers in different economic sectors....

  12. Accounting for School-Sector Differences in University Entrance Performance

    ERIC Educational Resources Information Center

    Marks, Gary

    2009-01-01

    School-sector differences in student performance are often viewed as largely reflecting the intake characteristics of students and having little to do with differences in the provision of teaching and learning between school sectors. The contrary view is that school-sector differences show that non-government schools "add value" to…

  13. The private sector's role in public sector genetically engineered crop projects.

    PubMed

    Potrykus, Ingo

    2010-11-30

    There is widespread interest within academia to work on public good genetically engineered (GE) projects to the benefit of the poor, especially to use GE-technology to contribute to food security. Not a single product from this work has reached the market. The major cause is GE-regulation, which prevents use of the technology for public good beyond proof-of-concept (Potrykus, I. (2010) Lessons from the Humanitarian Golden Rice project: Regulation prevents development of public good GE-products (these Proceedings)). There is, however, another key problem responsible for the lack of deployment of public good GE-plants: the public sector is incompetent and disinterested for work beyond proof-of-concept, and has neither capability nor funding to develop GE-plant products and introduce them to growers and consumers. The private sector has the expertise for both and in the right circumstances can be ready to support the public sector in public good enterprises. Public-private-partnerships are the best solution so far, to advance exploitation of GE-technology to the benefit of the poor. Public-private-partnerships are viable, however, only, if there is mutual interest from the private sector and initiative and funding from the public sector.

  14. Spectroscopic Properties of Novel Aromatic Metal Clusters: NaM4 (M=Al, Ga, In) and their Cations and Anions

    SciTech Connect

    Balasubramanian, K; Zhao, C

    2004-03-17

    The ground and several excited states of metal aromatic clusters, namely NaM4 and NaM{sub 4}{sup {+-}} (M=Al, Ga, In) clusters have been investigated by employing complete activespace self-consistent-field (CASSCF) followed by Multi-reference singles and doubles configuration interaction (MRSDCI) computations that included up to 10 million configurations and other methods. The ground states NaM{sub 4}{sup -} of aromatic anions are found to be symmetric C{sub 4v} ({sup 1}A{sub 1}) electronic states with ideal square pyramid geometries. While the ground state of NaIn4 is also predicted to be a symmetric C{sub 4v} ({sup 2}A{sub 1}) square pyramid, the ground state of the NaAl4 cluster is found to have a C{sub 2v} ({sup 2}A{sub 1}) pyramid with a rhombus base and the ground state of NaGa{sub 4} possesses a C{sub 2v} ({sup 2}A{sub 1}) pyramid with a rectangle base. In general these structures exhibit 2 competing geometries, viz., an ideal C{sub 4v} structure and a distorted rhomboidal or rectangular pyramid structure (C{sub 2v}). All of the ground states of the NaM{sub 4}{sup +} (M= Al, Ga, In) cations are computed to be C{sub 2v} ({sup 3}A{sub 2}) pyramids with rhombus bases. The equilibrium geometries, vibrational frequencies, dissociation energies, adiabatic ionization potentials, adiabatic electron affinities for the electronic states of NaM{sub 4} (M=Al, Ga, In) and their ions are computed and compared with experimental results and other theoretical calculations. On the basis of our computed excited states energy separations, we have tentatively suggested assignments to the observed X and A states in the anion photoelectron spectra of Al{sub 4}Na{sup -} reported by Li et al. The X state can be assigned to a C{sub 2v} ({sup 2}A{sub 1}) rhomboidal pyramid. The A state observed in the anion spectrum is assigned to the first excited state ({sup 2}B{sub 1}) of the neutral NaAl{sub 4} with the C{sub 4v} symmetry. The assignments of the excited states are consistent with

  15. Correction of vitamin D deficiency using sublingually administered vitamin D2 in a Crohn's disease patient with mal-absorption and a new ileostomy.

    PubMed

    McCullough, Patrick; Heaney, Robert

    2016-12-31

    Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2. A 58 year-old white female was admitted with a new ileostomy following partial bowel resection due to complications from Crohn's disease. She was found to be severely vitamin D deficient at the time of admission, with a level of 6.1ng/ml on hospital day 3. Her treatment with vitamin D was delayed for a few days. She was initially treated with 5000 units of vitamin D3 orally twice a day for 3days (days 7-10). After discussion with the patient and obtaining her consent, vitamin D3 was stopped, and she was then treated with a total of 8 doses of 50,000 units of vitamin D2 administered sublingually. She was given the first 3 doses on alternating days (days 11, 13, 15), and then 5 more doses on consecutive days (days 17-21). The rise in her 25-hydroxyvitamin D level in response to treatment with sublingual vitamin D2 was significant. On day 10, after receiving 3days of orally administered vitamin D3, her level was 9.8ng/ml. One week later, after receiving 3 sublingual doses of vitamin D2, it rose to 20.3ng/ml. It was then measured on alternating days twice over the next 4days, and it rose to 45.5ng/ml, and then to 47.4ng/ml on the day of discharge to home. The major finding of this study is that sublingual administration of vitamin D2 appears to

  16. Public-Private Partnerships in China's Urban Water Sector

    NASA Astrophysics Data System (ADS)

    Zhong, Lijin; Mol, Arthur P. J.; Fu, Tao

    2008-06-01

    During the past decades, the traditional state monopoly in urban water management has been debated heavily, resulting in different forms and degrees of private sector involvement across the globe. Since the 1990s, China has also started experiments with new modes of urban water service management and governance in which the private sector is involved. It is premature to conclude whether the various forms of private sector involvement will successfully overcome the major problems (capital shortage, inefficient operation, and service quality) in China’s water sector. But at the same time, private sector involvement in water provisioning and waste water treatments seems to have become mainstream in transitional China.

  17. Counting (green) jobs in Queensland's waste and recycling sector.

    PubMed

    Davis, Georgina

    2013-09-01

    The waste and recycling sector has been identified as a green industry and, as such, jobs within this sector may be classed as 'green jobs'. Many governments have seen green jobs as a way of increasing employment, particularly during the global financial crisis. However, the methods used to define and quantify green jobs directly affect the quantification of these green jobs. In December 2010, Queensland introduced a waste strategy that stated intent to increase green jobs within the waste sector. This article discusses the milieu and existing issues associated with quantifying green jobs within Queensland's waste and recycling sector, and provides a review of the survey that has sought to quantify the true size of the Queensland industry sector. This research has identified nearly 5500 jobs in Queensland's private waste management and recycling sector, which indicates that official data do not accurately reflect the true size of the sector.

  18. Financial development and sectoral CO2 emissions in Malaysia.

    PubMed

    Maji, Ibrahim Kabiru; Habibullah, Muzafar Shah; Saari, Mohd Yusof

    2017-03-01

    The paper examines the impacts of financial development on sectoral carbon emissions (CO2) for environmental quality in Malaysia. Since the financial sector is considered as one of the sectors that will contribute to Malaysian economy to become a developed country by 2020, we utilize a cointegration method to investigate how financial development affects sectoral CO2 emissions. The long-run results reveal that financial development increases CO2 emissions from the transportation and oil and gas sector and reduces CO2 emissions from manufacturing and construction sectors. However, the elasticity of financial development is not significant in explaining CO2 emissions from the agricultural sector. The results for short-run elasticities were also consistent with the long-run results. We conclude that generally, financial development increases CO2 emissions and reduces environmental quality in Malaysia.

  19. Sustainable fuel for the transportation sector

    PubMed Central

    Agrawal, Rakesh; Singh, Navneet R.; Ribeiro, Fabio H.; Delgass, W. Nicholas

    2007-01-01

    A hybrid hydrogen-carbon (H2CAR) process for the production of liquid hydrocarbon fuels is proposed wherein biomass is the carbon source and hydrogen is supplied from carbon-free energy. To implement this concept, a process has been designed to co-feed a biomass gasifier with H2 and CO2 recycled from the H2-CO to liquid conversion reactor. Modeling of this biomass to liquids process has identified several major advantages of the H2CAR process. (i) The land area needed to grow the biomass is <40% of that needed by other routes that solely use biomass to support the entire transportation sector. (ii) Whereas the literature estimates known processes to be able to produce ≈30% of the United States transportation fuel from the annual biomass of 1.366 billion tons, the H2CAR process shows the potential to supply the entire United States transportation sector from that quantity of biomass. (iii) The synthesized liquid provides H2 storage in an open loop system. (iv) Reduction to practice of the H2CAR route has the potential to provide the transportation sector for the foreseeable future, using the existing infrastructure. The rationale of using H2 in the H2CAR process is explained by the significantly higher annualized average solar energy conversion efficiency for hydrogen generation versus that for biomass growth. For coal to liquids, the advantage of H2CAR is that there is no additional CO2 release to the atmosphere due to the replacement of petroleum with coal, thus eliminating the need to sequester CO2. PMID:17360377

  20. Sustainable fuel for the transportation sector.

    PubMed

    Agrawal, Rakesh; Singh, Navneet R; Ribeiro, Fabio H; Delgass, W Nicholas

    2007-03-20

    A hybrid hydrogen-carbon (H(2)CAR) process for the production of liquid hydrocarbon fuels is proposed wherein biomass is the carbon source and hydrogen is supplied from carbon-free energy. To implement this concept, a process has been designed to co-feed a biomass gasifier with H(2) and CO(2) recycled from the H(2)-CO to liquid conversion reactor. Modeling of this biomass to liquids process has identified several major advantages of the H(2)CAR process. (i) The land area needed to grow the biomass is <40% of that needed by other routes that solely use biomass to support the entire transportation sector. (ii) Whereas the literature estimates known processes to be able to produce approximately 30% of the United States transportation fuel from the annual biomass of 1.366 billion tons, the H(2)CAR process shows the potential to supply the entire United States transportation sector from that quantity of biomass. (iii) The synthesized liquid provides H(2) storage in an open loop system. (iv) Reduction to practice of the H(2)CAR route has the potential to provide the transportation sector for the foreseeable future, using the existing infrastructure. The rationale of using H(2) in the H(2)CAR process is explained by the significantly higher annualized average solar energy conversion efficiency for hydrogen generation versus that for biomass growth. For coal to liquids, the advantage of H(2)CAR is that there is no additional CO(2) release to the atmosphere due to the replacement of petroleum with coal, thus eliminating the need to sequester CO(2).

  1. Sustainable fuel for the transportation sector

    SciTech Connect

    Agrawal, R.; Singh, N.R.; Ribeiro, F.H.; Delgass, W.N.

    2007-03-20

    A hybrid hydrogen-carbon (H{sub 2}CAR) process for the production of liquid hydrocarbon fuels is proposed wherein biomass is the carbon source and hydrogen is supplied from carbon-free energy. To implement this concept, a process has been designed to co-feed a biomass gasifier with H{sub 2} and CO{sub 2} recycled from the H{sub 2}-CO to liquid conversion reactor. Modeling of this biomass to liquids process has identified several major advantages of the H{sub 2}CAR process. The land area needed to grow the biomass is <40% of that needed by other routes that solely use biomass to support the entire transportation sector. Whereras the literature estimates known processes to be able to produce {approx}30% of the United States transportation fuel from the annual biomass of 1.366 billion tons, the H{sub 2}CAR process shows the potential to supply the entire United States transportation sector from that quantity of biomass. The synthesized liquid provides H{sub 2} storage in an open loop system. Reduction to practice of the H{sub 2}CAR route has the potential to provide the transportation sector for the foreseeable future, using the existing infrastructure. The rationale of using H{sub 2} in the H{sub 2}CAR process is explained by the significantly higher annualized average solar energy conversion efficiency for hydrogen generation versus that for biomass growth. For coal to liquids, the advantage of H{sub 2}CAR is that there is no additional CO{sub 2} release to the atmosphere due to the replacement of petroleum with coal, thus eliminating the need to sequester CO{sub 2}.

  2. Transferring technology to the public sector.

    NASA Technical Reports Server (NTRS)

    Alper, M. E.

    1972-01-01

    Approximately four years ago the Jet Propulsion Laboratory, under NASA sponsorship, began to devote some of its resources to examining ways to transfer space technology to the civil sector. As experience accumulated under this program, certain principles basic to success in technology transfer became apparent. An adequate definition of each problem must be developed before any substantial effort is expended on a solution. In most instances, a source of funds other than the potential user is required to support the problem definition phase of the work. Sensitivity to the user's concerns and effective interpersonal communications between the user and technical personnel are essential to success.

  3. Airlift Recirculation Well Final Report - Southern Sector

    SciTech Connect

    White, R.M.

    1999-05-18

    Chlorinated solvents used in the A/M-Area at the Savannah River Site (SRS) from 1952-1982 have contaminated the groundwater under the site. To comply with the requirements of the current SCDHEC Part B Permit, this plume is being addressed by a multi-phase program under the direction of the Environmental Restoration Division at SRS. This report details the first phase of this program, the containment of the portion of the plume greater than 500 ppb (TCE) within the Southern Sector of the A/M Area.

  4. Interacting dark sector with transversal interaction

    SciTech Connect

    Chimento, Luis P.; Richarte, Martín G.

    2015-03-26

    We investigate the interacting dark sector composed of dark matter, dark energy, and dark radiation for a spatially flat Friedmann-Robertson-Walker (FRW) background by introducing a three-dimensional internal space spanned by the interaction vector Q and solve the source equation for a linear transversal interaction. Then, we explore a realistic model with dark matter coupled to a scalar field plus a decoupled radiation term, analyze the amount of dark energy in the radiation era and find that our model is consistent with the recent measurements of cosmic microwave background anisotropy coming from Planck along with the future constraints achievable by CMBPol experiment.

  5. In vivo subcellular localization of Mal de Río Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions.

    PubMed

    Maroniche, Guillermo A; Mongelli, Vanesa C; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar; del Vas, Mariana

    2012-09-01

    The in vivo subcellular localization of Mal de Río Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and α-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.

  6. Palmoplantar keratoderma of the Gamborg-Nielsen type is caused by mutations in the SLURP1 gene and represents a variant of Mal de Meleda.

    PubMed

    Zhao, Linshu; Vahlquist, Anders; Virtanen, Marie; Wennerstrand, Lena; Lind, Lisbet K; Lundström, Anita; Hellström Pigg, Maritta

    2014-11-01

    Palmoplantar keratoderma of the Gamborg-Nielsen type (PPK-GN) is a rare autosomal recessive skin disorder described in patients from Sweden. Mal de Meleda (MDM) is also a rare autosomal recessive inherited PPK first reported in 5 families from the island of Meleda. The 2 conditions phenotypically overlap and are characterised by palmoplantar erythematous hyperkeratotic plaques. The genetic background giving rise to PPK-GN has hitherto been unknown, whereas MDM is known to be caused by mutations in the gene encoding secreted Ly-6/uPAR-related protein 1, SLURP-1. In the present study we scrutinised individuals affected by PPK-GN for mutations in the SLURP1 gene and identified 2 different mutations. Fourteen Swedish patients were homozygous for a previously described mutation, c.43T>C, while one individual was a compound heterozygote with one copy of a novel mutation, c.280T>A, in addition to one copy of the c.43T>C mutation. Hereby we confirm that PPK-GN is an allelic variant of MDM.

  7. Provenance of the Permian Malužiná Formation sandstones (Malé Karpaty Mountains, Western Carpathians): evidence of garnet and tourmaline mineral chemistry

    NASA Astrophysics Data System (ADS)

    Vďačný, Marek; Bačík, Peter

    2015-04-01

    The chemistry of detrital garnets (almandine; spessartine-, grossular-, and pyrope-rich almandine; andradite) and mostly dravitic tourmalines from three sandstone samples of the Permian Malužiná Formation in the northern part of the Malé Karpaty Mts (Western Carpathians, SW Slovakia) reveals a great variability of potential source rocks. They comprise (1) low-grade regionally metamorphosed rocks (metacherts, blue schists, metapelites and metapsammites), (2) contact-thermal metamorphic calcareous rocks (skarns or rodingites), (3) garnet-bearing mica schists and gneisses resulting from the regional metamorphism of argillaceous sediments, (4) amphibolites and metabasic sub-ophiolitic rocks, (5) granulites, (6) Li-poor granites and their associated pegmatites and aplites as well as (7) rhyolites. Consequently, the post-Variscan, rift-related sedimentary basin of the Malužiná Formation originated in the vicinity of a low- to high-grade crystalline basement with granitic rocks. Such lithological types of metamorphic and magmatic rocks are characteristic for the Variscan terranes of the Central Western Carpathians (Tatricum and Veporicum Superunits).

  8. Evidence for a major susceptibility locus at 11q22.1-23.3 has been detected in a large Chinese family with pure grand mal epilepsy.

    PubMed

    Yang, Mao Sheng; Wang, Xue Feng; Qin, Wei; Feng, Guo Yin; He, Lin

    2003-08-07

    Pure grand mal epilepsy (PGME) is a common subtype of idiopathic generalized epilepsy (IGE) with an unclear mode of inheritance. Several studies with the multiple families have provided evidence for the disorder to be linked to chromosome 8q24 and 8p. In this work, we performed an autosomal-wide scan linkage analysis using microsatellite markers in a large Chinese family with PGME and found seven markers with likelihood of odds (LOD), scores >/=1.0 (theta=0) in chromosome 11q22.1-23.3. The highest LOD score for two-point and multi-point linkage analysis are 1.99 (theta=0) at marker D11S4159 and 2.18 between markers D11S1782 and D11S3178, respectively, which reached the level of a suggested positive linkage LOD score (Z>/=1.9), under an autosomal dominant manner of inheritance with a penetrance of 65% but no significant positive LOD score (Z>/=3.3) was found after high density of microsatellite markers used in the regions. Obviously, our data do not support the linkage of the disease to chromosome 8q24 and 8p but implicate that chromosome 11q22.1-23.3 may be a new locus linked to PGME, which indicates the existence of genetic heterogeneity in the disorder.

  9. Aflatoxin exposure during the first 36 months of life was not associated with impaired growth in Nepalese children: An extension of the MAL-ED study

    PubMed Central

    Hsu, Hui-Husan; Chandyo, Ram Krishna; Shrestha, Binob; Bodhidatta, Ladaporn; Tu, Yu-Kang; Gong, Yun-Yun; Egner, Patricia A.; Ulak, Manjeswori; Groopman, John D.; Wu, Felicia

    2017-01-01

    Exposure to aflatoxin, a mycotoxin common in many foods, has been associated with child growth impairment in sub-Saharan Africa. To improve our understanding of growth impairment in relation to aflatoxin and other risk factors, we assessed biospecimens collected in Nepalese children at 15, 24, and 36 months of age for aflatoxin exposure. Children (N = 85) enrolled in the Bhaktapur, Nepal MAL-ED study encompassed the cohort analysed in this study. Exposure was assessed through a plasma biomarker of aflatoxin exposure: the AFB1-lysine adduct. The aflatoxin exposures in the study participants were compared to anthropometrics at each time period (length-for-age [LAZ], weight-for-age [WAZ], and weight-for-length [WLZ] z-scores), growth trajectories over time, age, and breastfeeding status. Results demonstrated chronic aflatoxin exposure in this cohort of children, with a geometric mean of 3.62 pg AFB1-lysine/mg albumin. However, the chronic aflatoxin exposure in this cohort was not significantly associated with anthropometric z-scores, growth trajectories, age, or feeding status, based on the available time points to assess aflatoxin exposure. Low mean levels of aflatoxin exposure and infrequent occurrence of stunting, wasting, or underweight z-score values in this cohort are possible contributing factors to a lack of evidence for an association. Further research is needed to examine whether a threshold dose of aflatoxin exists that could induce child growth impairment. PMID:28212415

  10. In vivo subcellular localization of Mal de Rio Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions

    SciTech Connect

    Maroniche, Guillermo A.; Mongelli, Vanesa C.; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar

    2012-09-01

    The in vivo subcellular localization of Mal de Rio Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and {alpha}-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.

  11. A quantum Monte Carlo study on electron correlation in all-metal aromatic clusters MAl4(-) (M = Li, Na, K, Rb, Cu, Ag and Au).

    PubMed

    Brito, Bráulio Gabriel A; Hai, G-Q; Teixeira Rabelo, J N; Cândido, Ladir

    2014-05-14

    Using fixed-node diffusion quantum Monte Carlo (FN-DMC) simulation we investigate the electron correlation in all-metal aromatic clusters MAl4(-) (with M = Li, Na, K, Rb, Cu, Ag and Au). The electron detachment energies and electron affinities of the clusters are obtained. The vertical electron detachment energies obtained from the FN-DMC calculations are in very good agreement with the available experimental results. Calculations are also performed within the Hartree-Fock approximation, density-functional theory (DFT), and the couple-cluster (CCSD(T)) method. From the obtained results, we analyse the impact of the electron correlation effects in these bimetallic clusters and find that the correlation of the valence electrons contributes significantly to the detachment energies and electron affinities, varying between 20% and 50% of their total values. Furthermore, we discuss the electron correlation effects on the stability of the clusters as well as the accuracy of the DFT and CCSD(T) calculations in the present systems.

  12. The etiology, risk factors, and interactions of enteric infections and malnutrition and the consequences for child health and development study (MAL-ED): description of the Tanzanian site.

    PubMed

    Mduma, Estomih R; Gratz, Jean; Patil, Crystal; Matson, Kristine; Dakay, Mary; Liu, Sarah; Pascal, John; McQuillin, Lauren; Mighay, Emmanuel; Hinken, Elizabeth; Ernst, Alexandra; Amour, Caroline; Mvungi, Regisiana; Bayyo, Eliwaza; Zakaria, Yeconia; Kivuyo, Sokoine; Houpt, Eric R; Svensen, Erling

    2014-11-01

    The Haydom, Tanzania, site (TZH) of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) Study is in north-central Tanzania, 300 km from the nearest urban center. TZH is in a remote rural district where most of the population are agropastoralists and grow maize as the staple food. The average household size is 7. The average woman achieves a parity of 6 and has 1 child death. Socioeconomic indicators are poor, with essentially no household having access to electricity, piped water, or improved sanitary facilities (compared with 14%, 7%, and 12%, respectively, reported nationally). The Demographic Health Survey Tanzania 2004 indicated that the region had high rates of stunting and underweight (40% and 31% of children aged <5 years had a height-for-age z score and weight-for-age z score, respectively, of <-2 ) and an under-5 child mortality rate of 5.8%. Human immunodeficiency virus prevalence among 18-month-old children is <0.5%. TZH represents a remote rural African population with profound poverty and malnutrition, but a strong community-based research infrastructure.

  13. Aflatoxin exposure during the first 36 months of life was not associated with impaired growth in Nepalese children: An extension of the MAL-ED study.

    PubMed

    Mitchell, Nicole J; Hsu, Hui-Husan; Chandyo, Ram Krishna; Shrestha, Binob; Bodhidatta, Ladaporn; Tu, Yu-Kang; Gong, Yun-Yun; Egner, Patricia A; Ulak, Manjeswori; Groopman, John D; Wu, Felicia

    2017-01-01

    Exposure to aflatoxin, a mycotoxin common in many foods, has been associated with child growth impairment in sub-Saharan Africa. To improve our understanding of growth impairment in relation to aflatoxin and other risk factors, we assessed biospecimens collected in Nepalese children at 15, 24, and 36 months of age for aflatoxin exposure. Children (N = 85) enrolled in the Bhaktapur, Nepal MAL-ED study encompassed the cohort analysed in this study. Exposure was assessed through a plasma biomarker of aflatoxin exposure: the AFB1-lysine adduct. The aflatoxin exposures in the study participants were compared to anthropometrics at each time period (length-for-age [LAZ], weight-for-age [WAZ], and weight-for-length [WLZ] z-scores), growth trajectories over time, age, and breastfeeding status. Results demonstrated chronic aflatoxin exposure in this cohort of children, with a geometric mean of 3.62 pg AFB1-lysine/mg albumin. However, the chronic aflatoxin exposure in this cohort was not significantly associated with anthropometric z-scores, growth trajectories, age, or feeding status, based on the available time points to assess aflatoxin exposure. Low mean levels of aflatoxin exposure and infrequent occurrence of stunting, wasting, or underweight z-score values in this cohort are possible contributing factors to a lack of evidence for an association. Further research is needed to examine whether a threshold dose of aflatoxin exists that could induce child growth impairment.

  14. Repression vs. activation of MOX, FMD, MPP1 and MAL1 promoters by sugars in Hansenula polymorpha: the outcome depends on cell's ability to phosphorylate sugar.

    PubMed

    Suppi, Sandra; Michelson, Tiina; Viigand, Katrin; Alamäe, Tiina

    2013-03-01

    A high-throughput approach was used to assess the effect of mono- and disaccharides on MOX, FMD, MPP1 and MAL1 promoters in Hansenula polymorpha. Site-specifically designed strains deficient for (1) hexokinase, (2) hexokinase and glucokinase, (3) maltose permease or (4) maltase were used as hosts for reporter plasmids in which β-glucuronidase (Gus) expression was controlled by these promoters. The reporter strains were grown on agar plates containing varied carbon sources and Gus activity was measured in permeabilized cells on microtitre plates. We report that monosaccharides (glucose, fructose) repress studied promoters only if phosphorylated in the cell. Glucose-6-phosphate was proposed as a sugar repression signalling metabolite for H. polymorpha. Intriguingly, glucose and fructose strongly activated expression from these promoters in strains lacking both hexokinase and glucokinase, indicating that unphosphorylated monosaccharides have promoter-derepressing effect. We also show that maltose and sucrose must be internalized and split into monosaccharides to exert repression on MOX promoter. We demonstrate that at yeast growth on glucose-containing agar medium, glucose-limitation is rapidly created that promotes derepression of methanol-specific promoters and that derepression is specifically enhanced in hexokinase-negative strain. We recommend double kinase-negative and hexokinase-negative mutants as hosts for heterologous protein production from MOX and FMD promoters.

  15. Functional and biochemical properties of Mal de Río Cuarto virus (Fijivirus, Reoviridae) P9-1 viroplasm protein show further similarities to animal reovirus counterparts.

    PubMed

    Maroniche, Guillermo A; Mongelli, Vanesa C; Peralta, Andrea V; Distéfano, Ana J; Llauger, Gabriela; Taboga, Oscar A; Hopp, Esteban H; del Vas, Mariana

    2010-09-01

    Mal de Río Cuarto virus (MRCV) is a plant virus of the genus Fijivirus within the family Reoviridae that infects several monocotyledonous species and is transmitted by planthoppers in a persistent and propagative manner. Other members of the family replicate in viral inclusion bodies (VIBs) termed viroplasms that are formed in the cytoplasm of infected plant and insect cells. In this study, the protein coded by the first ORF of MRCV segment S9 (P9-1) was shown to establish cytoplasmic inclusion bodies resembling viroplasms after transfection of Spodoptera frugiperda insect cells. In accordance, MRCV P9-1 self-associates giving rise to high molecular weight complexes when expressed in bacteria. Strong self-interaction was also evidenced by yeast two-hybrid assays. Furthermore, biochemical characterization showed that MRCV P9-1 bound single stranded RNA and had ATPase activity. Finally, the MRCV P9-1 region required for the formation of VIB-like structures was mapped to the protein carboxy-terminal half. This extensive functional and biochemical characterization of MRCV P9-1 revealed further similarities between plant and animal reovirus viroplasm proteins.

  16. [Molecular aspects of allergy to plant products. Part II. Pathogenesis-related proteins (PRs), apple allergenicity governed by Mal d 1 gene].

    PubMed

    Bokszczanin, Kamila Ł; Przybyła, Andrzej A

    2012-03-01

    Of the plant allergens listed in the Official Allergen Database of the International Union of Immunological Societies, approximately 25% belong to the group of pathogenesis-related proteins (PRs). They have been classified into 17 PR families based on similarities in their amino acid sequence, enzymatic activities, or other functional properties. Plant-derived allergens have been identified with sequence similarities to PR families 2, 3, 4, 5, 8, 10, and 14. The main birch allergen in northern Europe is a class 10 (PR-10) protein from the European white birch (Betula pendula) termed Bet v 1. Pollen of other Fagales species contains PR-10 homologues that share epitopes with Bet v 1, as do several fruits, nuts and vegetables. Among the plant food fruits of the Rosaceae family are the most frequently responsible for allergenic reactions. It is documented, that approximately 2% of European population is allergic to apples. The article presents molecular characterization of PR-10 proteins with regard to their structure and function as well as apple Mal d 1 gene-determined allergenicity.

  17. Geochemistry of amphibolites and related graphitic gneisses from the Suchý and Malá Magura Mountains (central Western Carpathians) - evidence for relics of the Variscan ophiolite complex

    NASA Astrophysics Data System (ADS)

    Ivan, Peter; Méres, Štefan

    2015-10-01

    Three small bodies of amphibolites and associated graphitic gneisses from the Suchý and Malá Magura Mountains (Tatric Megaunit, central Western Carpathians) have been studied by petrographic and geochemical methods. Isolated, fault-bounded bodies first hundreds of meters in size are located in the complex of the Early Paleozoic paragneisses and migmatites intruded by the Lower Carboniferous granitoid rocks. Amphibolites (locally actinolite schists) were formed from effusive basalts, dolerites or isotropic gabbros hydrothermally altered and veined before the regional metamorphic transformation. Distribution of the trace elements relatively immobile during the metamorphic alteration (HFSE, REE, Cr, V, Sc) is similar to E-MORB type in the Malá Magura Mountain or to N-MORB/E-MORB types in the Suchý Mountain. Graphitic gneisses to metacherts are rich in silica (up to 88 wt. %) and Ctot, poor in other major element contents and display negative Ce-anomaly, enrichment in HREE, V, Cr and U. They were probably originally deposited as non-carbonate and silica-rich deep-sea sediments in anoxic conditions. The oceanic provenance of amphibolites and related graphitic gneisses clearly indicates their oceanic crust affinity and identity with the uppermost part of the ophiolite sequence. Ophiolite bodies from the Suchý and Malá Magura Mountains are supposed to be relic fault blocks identical with the Upper Devonian Pernek Group which represents a Variscan ophiolite nappe preserved to large extent in the Malé Karpaty Mountains located in the Tatric Megaunit further to the southwest. All these ophiolite relics are vestiges of the original ophiolite suture created by oceanic closure in the Lower Carboniferous.

  18. Magnetic coupling through the carbon skeleton of malonate in two polymorphs of ([Cu(bpy)(H2O)][Cu(bpy)(mal)(H2O)])(ClO4)2 (H2mal = malonic acid; bpy = 2,2'-bipyridine).

    PubMed

    Ruiz-Pérez, C; Hernández-Molina, M; Lorenzo-Luis, P; Lloret, F; Cano, J; Julve, M

    2000-08-21

    Two polymorphic malonato-bridged copper(II) complexes of formula ([Cu(bpy)(H2O)][Cu(bpy)(mal)(H2O)])-(ClO4)2 (1 and 2) (bpy = 2,2'-bipyridine and mal = malonate dianion) have been prepared and their structures solved by X-ray diffraction methods. Compound 1 crystallizes in the monoclinic space group P2(1)/a, with a = 23.743(3) A, b = 9.7522(5) A, c = 27.731(2) A, beta = 114.580(10) degrees, and Z = 4. Compound 2 crystallizes in the orthorhombic space group Pbcn, with a = 23.700(5) A, b = 25.162(5) A, c = 9.693(5) A, and Z = 4. The structures of 1 and 2 are made up of uncoordinated perchlorate anions and malonate-bridged zigzag copper(II) chains grouped in an isosceles triangle running parallel to the b (1) and c (2) axes. These chains are built by a [Cu(bpy)(mal)(H2O)] unit acting as bis-monodentate ligand toward two [Cu(bpy)(H2O)] adjacent units through its OCCCO skeleton in an anti-anti conformation, whereas the OCO carboxylate bridges exhibit the anti-syn conformation. Compounds 1 and 2 contain four crystallographically independent copper(II) atoms, but the environment of all of them is distorted square pyramidal: the axial position is occupied by a water molecule, whereas the equatorial plane is formed by a chelating bpy and either a bidentate malonate or two carboxylate oxygens from two malonate groups. The equatorial Cu-O(mal) (1.911(4)-1.978(4) (1) and 1.897(5)-1.991(4) A (2)) and Cu-N(bpy) (1.983(4)-2.008(5) (1) and 1.971(6)-2.007(6) A (2)) bonds are somewhat shorter than the axial Cu-O(w) one (2.257(5)-2.524(5) (1) and 2.236(5)-2.505(6) A (2)). The angles subtended at the copper atom by the chelating bpy vary in the ranges 80.9(2)-81.8(2) degrees (1) and 80.4(2)-82.1(2) degrees (2), values which are somewhat smaller than those of the chelating malonate (80.4(2)-82.1(2) degrees (1) and 93.0(2)-93.6(2) degrees (2)). The intrachain copper-copper separations through the OCCCO fragment are 8.227(1) (1) and 8.206(2) A (2), whereas those through the OCO bridging

  19. [Health, hospitality sector and tobacco industry].

    PubMed

    Abella Pons, Francesc; Córdoba Garcia, Rodrigo; Suárez Bonel, Maria Pilar

    2012-11-01

    To present the strategies used by the tobacco industry to meet government regulatory measures of its products. To demonstrate the relationship between tobacco industry and the hospitality sector. Note that the arguments and strategies used routinely by the hospitality industry have been previously provided by the tobacco industry. Location of key documents by meta-search, links to declassified documents, specific websites of the tobacco and hospitality industry, news sources and published articles in health journals. This review reveals the close relationship between tobacco industry and hospitality sector. It highlights the strategies carried out by the tobacco industry, including strategic hoarding of information, public relations, lobbying, consultation program, smoker defence groups, building partnerships, intimidation and patronage. The arguments and strategies used by the hospitality industry to match point by point that used by the tobacco industry. These arguments are refutable from the point of view of public health as it is scientifically proven that totally smoke-free environments are the only way to protect non-smokers from tobacco smoke exposure and its harmful effects on health.

  20. Emissions from India's transport sector: Statewise synthesis

    NASA Astrophysics Data System (ADS)

    Ramachandra, T. V.; Shwetmala

    A decentralized emission inventories are prepared for road transport sector of India in order to design and implement suitable technologies and policies for appropriate mitigation measures. Globalization and liberalization policies of the government in 90's have increased the number of road vehicles nearly 92.6% from 1980-1981 to 2003-2004. These vehicles mainly consume non-renewable fossil fuels, and are a major contributor of green house gases, particularly CO 2 emission. This paper focuses on the statewise road transport emissions (CO 2, CH 4, CO, NO x, N 2O, SO 2, PM and HC), using region specific mass emission factors for each type of vehicles. The country level emissions (CO 2, CH 4, CO, NO x, N 2O, SO 2 and NMVOC) are calculated for railways, shipping and airway, based on fuel types. In India, transport sector emits an estimated 258.10 Tg of CO 2, of which 94.5% was contributed by road transport (2003-2004). Among all the states and Union Territories, Maharashtra's contribution is the largest, 28.85 Tg (11.8%) of CO 2, followed by Tamil Nadu 26.41 Tg (10.8%), Gujarat 23.31 Tg (9.6%), Uttar Pradesh 17.42 Tg (7.1%), Rajasthan 15.17 Tg (6.22%) and, Karnataka 15.09 Tg (6.19%). These six states account for 51.8% of the CO 2 emissions from road transport.

  1. The private sector, international development and NCDs

    PubMed Central

    2011-01-01

    This article addresses an area that has been largely underserved by the development community, and one in which there is a particularly good opportunity for the private sector to take a lead in making a difference to employees, customers and local communities: chronic, non-communicable diseases (NCDs). It highlights the extent of the epidemic of NCDs in developing countries, sets out the 'business case' for the private sector to act on NCDs, and gives examples of initiatives by business to ensure that the healthy choice really is an easier choice for employees, consumers and local communities. It makes the case that, to be genuinely sustainable, businesses should be addressing health as a core part of what they do and, by working in partnership - as called for by the Millennium Development Goals - they can make a real difference and become part of the solution. Identifying ways in which this can be done should form a key part both of planning for, and action after, the UN High-level Meeting on NCDs, to be held in September 2011. PMID:21798001

  2. The private sector, international development and NCDs.

    PubMed

    Hancock, Christine; Kingo, Lise; Raynaud, Olivier

    2011-07-28

    This article addresses an area that has been largely underserved by the development community, and one in which there is a particularly good opportunity for the private sector to take a lead in making a difference to employees, customers and local communities: chronic, non-communicable diseases (NCDs). It highlights the extent of the epidemic of NCDs in developing countries, sets out the 'business case' for the private sector to act on NCDs, and gives examples of initiatives by business to ensure that the healthy choice really is an easier choice for employees, consumers and local communities. It makes the case that, to be genuinely sustainable, businesses should be addressing health as a core part of what they do and, by working in partnership - as called for by the Millennium Development Goals - they can make a real difference and become part of the solution. Identifying ways in which this can be done should form a key part both of planning for, and action after, the UN High-level Meeting on NCDs, to be held in September 2011.

  3. Discovering Preferential Patterns in Sectoral Trade Networks.

    PubMed

    Cingolani, Isabella; Piccardi, Carlo; Tajoli, Lucia

    2015-01-01

    We analyze the patterns of import/export bilateral relations, with the aim of assessing the relevance and shape of "preferentiality" in countries' trade decisions. Preferentiality here is defined as the tendency to concentrate trade on one or few partners. With this purpose, we adopt a systemic approach through the use of the tools of complex network analysis. In particular, we apply a pattern detection approach based on community and pseudocommunity analysis, in order to highlight the groups of countries within which most of members' trade occur. The method is applied to two intra-industry trade networks consisting of 221 countries, relative to the low-tech "Textiles and Textile Articles" and the high-tech "Electronics" sectors for the year 2006, to look at the structure of world trade before the start of the international financial crisis. It turns out that the two networks display some similarities and some differences in preferential trade patterns: they both include few significant communities that define narrow sets of countries trading with each other as preferential destinations markets or supply sources, and they are characterized by the presence of similar hierarchical structures, led by the largest economies. But there are also distinctive features due to the characteristics of the industries examined, in which the organization of production and the destination markets are different. Overall, the extent of preferentiality and partner selection at the sector level confirm the relevance of international trade costs still today, inducing countries to seek the highest efficiency in their trade patterns.

  4. The AIDS threat and the private sector.

    PubMed

    Moore, D

    1999-01-01

    While commercial sector managers throughout southern Africa have invested considerable funds to ensure that reaching the year 2000 does not disrupt the routine functioning of their computer systems, they are failing to address the considerable damage which HIV/AIDS will likely inflict upon companies' human resources. How these managers address AIDS in the workplace will determine whether their companies survive the first decade of the 21st century. Based upon the most recently available statistics, the Metropolitan-Doyle model, developed in 1988 to produce estimates of the progression of HIV/AIDS in South Africa, projects that as of 1999, 11% of South Africa's work force is infected with HIV and an estimated 0.6% are sick with AIDS. The percentages of the country's work force projected to have HIV and to be sick due to AIDS in 2010 are 21% and 2.9%, respectively. The direct costs of AIDS will be felt through rising employee benefit and medical insurance costs, and there will also be numerous indirect costs in the workplace. Management and labor need to work together to find a proactive, holistic solution to the AIDS crisis facing South Africa. The indirect costs of HIV/AIDS to the commercial sector and the elements of a holistic solution to the AIDS problem are discussed.

  5. Environmental management in North American mining sector.

    PubMed

    Asif, Zunaira; Chen, Zhi

    2016-01-01

    This paper reviews the environmental issues and management practices in the mining sector in the North America. The sustainable measures on waste management are recognized as one of the most serious environmental concerns in the mining industry. For mining activities, it will be no surprise that the metal recovery reagents and acid effluents are a threat to the ecosystem as well as hazards to human health. In addition, poor air quality and ventilation in underground mines can lead to occupational illness and death of workers. Electricity usage and fuel consumption are major factors that contribute to greenhouse gases. On the other hand, many sustainability challenges are faced in the management of tailings and disposal of waste rock. This paper aims to highlight the problems that arise due to poor air quality and acid mine drainage. The paper also addresses some of the advantages and limitations of tailing and waste rock management that still have to be studied in context of the mining sector. This paper suggests that implementation of suitable environmental management tools like life cycle assessment (LCA), cleaner production technologies (CPTs), and multicriteria decision analysis (MCD) are important as it ultimately lead to improve environmental performance and enabling a mine to focus on the next stage of sustainability.

  6. Hidden sector DM models and Higgs physics

    SciTech Connect

    Ko, P.

    2014-06-24

    We present an extension of the standard model to dark sector with an unbroken local dark U(1){sub X} symmetry. Including various singlet portal interactions provided by the standard model Higgs, right-handed neutrinos and kinetic mixing, we show that the model can address most of phenomenological issues (inflation, neutrino mass and mixing, baryon number asymmetry, dark matter, direct/indirect dark matter searches, some scale scale puzzles of the standard collisionless cold dark matter, vacuum stability of the standard model Higgs potential, dark radiation) and be regarded as an alternative to the standard model. The Higgs signal strength is equal to one as in the standard model for unbroken U(1){sub X} case with a scalar dark matter, but it could be less than one independent of decay channels if the dark matter is a dark sector fermion or if U(1){sub X} is spontaneously broken, because of a mixing with a new neutral scalar boson in the models.

  7. Configuring Airspace Sectors with Approximate Dynamic Programming

    NASA Technical Reports Server (NTRS)

    Bloem, Michael; Gupta, Pramod

    2010-01-01

    In response to changing traffic and staffing conditions, supervisors dynamically configure airspace sectors by assigning them to control positions. A finite horizon airspace sector configuration problem models this supervisor decision. The problem is to select an airspace configuration at each time step while considering a workload cost, a reconfiguration cost, and a constraint on the number of control positions at each time step. Three algorithms for this problem are proposed and evaluated: a myopic heuristic, an exact dynamic programming algorithm, and a rollouts approximate dynamic programming algorithm. On problem instances from current operations with only dozens of possible configurations, an exact dynamic programming solution gives the optimal cost value. The rollouts algorithm achieves costs within 2% of optimal for these instances, on average. For larger problem instances that are representative of future operations and have thousands of possible configurations, excessive computation time prohibits the use of exact dynamic programming. On such problem instances, the rollouts algorithm reduces the cost achieved by the heuristic by more than 15% on average with an acceptable computation time.

  8. Mathematical Models for the Education Sector, A Survey. (Les Modeles Mathematiques du Sector Enseignement.) Technical Report.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    The purposes of this volume are to report a survey of current practice in the construction and use of mathematical models for the education sector: to identify the most important technical and substantive problems confronting the model-building effort; and to bridge the gap between the advancing research pursuit of model-building and the lagging…

  9. Prevalence of maltreatment among youths in public sectors of care.

    PubMed

    Miller, Elizabeth A; Green, Amy E; Fettes, Danielle L; Aarons, Gregory A

    2011-08-01

    Few studies have investigated the prevalence of maltreatment among youths in public sectors of care despite the critical public health concern and the burden of suffering on such youths. The current study examined the prevalence of multiple types of maltreatment across five public sectors of care. Youths aged 11-18 (n = 1,135) enrolled in one of five public sectors of care reported on their maltreatment history using the Childhood Trauma Questionnaire. Across all sectors, 78% of youth reported experiencing at least moderate levels of maltreatment with the majority (58%) reporting multiple types of maltreatment. The prevalence of maltreatment was highest for youths involved in the alcohol/drug (86%) and child welfare (85%) sectors, and lowest in the serious emotional disturbance sector (72%). Logistic regressions were conducted to examine differences in the likelihood of multiple types of maltreatment by sector affiliation, controlling for the effects of gender, race/ethnicity, and age. The results indicate that rates of maltreatment across sectors do not differ greatly from those in child welfare. The high incidence of maltreatment across all sectors, not solely child welfare, indicates that all youth in public sectors of care should be screened for a history of maltreatment when they enter into care.

  10. Health sector reform and public sector health worker motivation: a conceptual framework.

    PubMed

    Franco, Lynne Miller; Bennett, Sara; Kanfer, Ruth

    2002-04-01

    Motivation in the work context can be defined as an individual's degree of willingness to exert and maintain an effort towards organizational goals. Health sector performance is critically dependent on worker motivation, with service quality, efficiency, and equity, all directly mediated by workers' willingness to apply themselves to their tasks. Resource availability and worker competence are essential but not sufficient to ensure desired worker performance. While financial incentives may be important determinants of worker motivation, they alone cannot and have not resolved all worker motivation problems. Worker motivation is a complex process and crosses many disciplinary boundaries, including economics, psychology, organizational development, human resource management, and sociology. This paper discusses the many layers of influences upon health worker motivation: the internal individual-level determinants, determinants that operate at organizational (work context) level, and determinants stemming from interactions with the broader societal culture. Worker motivation will be affected by health sector reforms which potentially affect organizational culture, reporting structures, human resource management, channels of accountability, types of interactions with clients and communities, etc. The conceptual model described in this paper clarifies ways in which worker motivation is influenced and how health sector reform can positively affect worker motivation. Among others, health sector policy makers can better facilitate goal congruence (between workers and the organizations they work for) and improved worker motivation by considering the following in their design and implementation of health sector reforms: addressing multiple channels for worker motivation, recognizing the importance of communication and leadership for reforms, identifying organizational and cultural values that might facilitate or impede implementation of reforms, and understanding that reforms

  11. A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 1: inflammatory and aesthetic indications.

    PubMed

    Calzavara-Pinton, Pier Giacomo; Rossi, Maria Teresa; Aronson, Erica; Sala, Raffaella

    2013-01-01

    Experimental investigations have demonstrated that photodynamic therapy (PDT) with methyl aminolevulinate (MAL) may be a useful treatment in several inflammatory skin disorders and aesthetic indications. To assess the effectiveness, tolerability and safety of off-label MAL-PDT in daily clinical practice in 20 Italian hospital centers, a retrospective observational study of medical records of patients treated for off-label inflammatory and aesthetic indications was carried out. In all patients standard treatment options had been either ineffective, unacceptably toxic, or medically contraindicated. Clinical data regarding 221 patients affected by 22 different diseases were collected. The most common off-label indication was acne vulgaris, with >75% improvement in 72.8% of patients. Other disorders of the sebaceous gland, i.e. acne rosacea, hidradenitis suppurativa and sebaceous hyperplasia, were less responsive. Alopecia areata did not show any improvement. Granuloma annulare and necrobiosis lipoidica showed marked or moderate response in the majority of treated patients. The rate of patients with complete remission was lower for inflammatory skin disorders with hyperkeratosis, i.e. psoriasis (6/17) and porokeratosis (3/16). The efficacy for lichenoid dermatoses was dependent on the clinical variant (erosive and scleroatrophic were more responsive than hypertrophic). Only 1 of 6 patients with Zoon balanitis had a marked improvement. MAL-PDT of venous leg ulcers, photo-aging and hypertrophic scars led to a marked remission in 3/5, 3/6 and 5/8 patients, respectively. The treatment had to be interrupted because of strong pain and burning in 24 patients. Long term adverse events were not registered. Most patients with marked improvement had lasting remission with overall excellent cosmetic outcomes. The present findings demonstrate a high interest in off-label uses of MAL-PDT for inflammatory skin disorders. According to the observed clinical responses, safety, and

  12. Effect of Dynamic Sector Boundary Changes on Air Traffic Controllers

    NASA Technical Reports Server (NTRS)

    Jung, Jaewoo; Lee, Paul; Kessell, Angela; Homola, Jeff; Zelinski, Shannon

    2010-01-01

    The effect of dynamic sector boundary changes on air traffic controller workload was investigated with data from a human-in-the-loop simulation. Multiple boundary changes were made during simulated operations, and controller rating of workload was recorded. Analysis of these data showed an increase of 16.9% in controller workload due to boundary changes. This increased workload was correlated with the number of aircraft handoffs and change in sector volume. There was also a 12.7% increase in average workload due to the changed sector design after boundary changes. This increase was correlated to traffic flow crossing points getting closer to sector boundaries and an increase in the number of flights with short dwell time in a sector. This study has identified some of the factors that affect controller workload when sector boundaries are changed, but more research is needed to better understand their relationships.

  13. Child and Adolescent Obesity and Employment Sector in Urban China

    PubMed Central

    Li, Yi; Zimmer, Zachary

    2013-01-01

    Despite its importance as a part of the economic reform in China, sectoral employment has been overlooked as a potential determinant of child and adolescent obesity (CAO). Using large-scale longitudinal data from surveys conducted from 1989 to 2006, this paper examines the relationship between the sector in which a parent is employed and CAO, with the sector being based on ownership and categorised as either state or non-state. Analyses of over 1,700 children and adolescents show that children and adolescents whose parents work in the state sector are less likely to be obese. Patterns of sectoral employment's effect are robust across time periods, in fixed-effects models, and across multiple measures of obesity. Additionally, the paper shows that socioeconomic characteristics of the parent, such as income, education, and occupation, typically thought to be important predictors of CAO, are not as important when the parental working sector is included in the models. PMID:24298293

  14. Interacting vacuum energy in the dark sector

    SciTech Connect

    Chimento, L. P.; Carneiro, S.

    2015-03-26

    We analyse three cosmological scenarios with interaction in the dark sector, which are particular cases of a general expression for the energy flux from vacuum to matter. In the first case the interaction leads to a transition from an unstable de Sitter phase to a radiation dominated universe, avoiding in this way the initial singularity. In the second case the interaction gives rise to a slow-roll power-law inflation. Finally, the third scenario is a concordance model for the late-time universe, with the vacuum term decaying into cold dark matter. We identify the physics behind these forms of interaction and show that they can be described as particular types of the modified Chaplygin gas.

  15. Supersymmetric leptogenesis with a light hidden sector

    SciTech Connect

    De Simone, Andrea; Garny, Mathias; Ibarra, Alejandro; Weniger, Christoph E-mail: mathias.garny@ph.tum.de E-mail: christoph.weniger@desy.de

    2010-07-01

    Supersymmetric scenarios incorporating thermal leptogenesis as the origin of the observed matter-antimatter asymmetry generically predict abundances of the primordial elements which are in conflict with observations. In this paper we propose a simple way to circumvent this tension and accommodate naturally thermal leptogenesis and primordial nucleosynthesis. We postulate the existence of a light hidden sector, coupled very weakly to the Minimal Supersymmetric Standard Model, which opens up new decay channels for the next-to-lightest supersymmetric particle, thus diluting its abundance during nucleosynthesis. We present a general model-independent analysis of this mechanism as well as two concrete realizations, and describe the relevant cosmological and astrophysical bounds and implications for this dark matter scenario. Possible experimental signatures at colliders and in cosmic-ray observations are also discussed.

  16. Occupational Hazards in the Thai Healthcare Sector.

    PubMed

    Tipayamongkholgul, Mathuros; Luksamijarulkul, Pipat; Mawn, Barbara; Kongtip, Pornpimol; Woskie, Susan

    2016-05-01

    Healthcare personnel work in vulnerable conditions that can adversely impact physical and/or mental health. This paper aims to synthesize the state of knowledge on work-related illnesses, injuries, and risks experienced by Thai healthcare workers. We found that Thai healthcare personnel, like others worldwide, are at risk for injury related to needle sticks and sharp instruments; infectious diseases due to biological hazards exposure such as airborne pathogens and patient secretions; muscle pain due to workload and long duration of work; and psychological disorders related to stressful working conditions. Because detailed surveillance data are limited for the Thai healthcare workforce, we recommend that additional surveillance data on Thai healthcare workers' health outcomes be collected. Future research efforts should also focus on evidence-based interventions in order to develop methods to prevent and treat occupational health injuries and illnesses acquired in the workplace for Thai healthcare sector workers.

  17. Interacting vacuum energy in the dark sector

    NASA Astrophysics Data System (ADS)

    Chimento, L. P.; Carneiro, S.

    2015-03-01

    We analyse three cosmological scenarios with interaction in the dark sector, which are particular cases of a general expression for the energy flux from vacuum to matter. In the first case the interaction leads to a transition from an unstable de Sitter phase to a radiation dominated universe, avoiding in this way the initial singularity. In the second case the interaction gives rise to a slow-roll power-law inflation. Finally, the third scenario is a concordance model for the late-time universe, with the vacuum term decaying into cold dark matter. We identify the physics behind these forms of interaction and show that they can be described as particular types of the modified Chaplygin gas.

  18. Solar Photovoltaic Financing: Residential Sector Deployment

    SciTech Connect

    Coughlin, J.; Cory, K.

    2009-03-01

    This report presents the information that homeowners and policy makers need to facilitate PV financing at the residential level. The full range of cash payments, bill savings, and tax incentives is covered, as well as potentially available solar attribute payments. Traditional financing is also compared to innovative solutions, many of which are borrowed from the commercial sector. Together, these mechanisms are critical for making the economic case for a residential PV installation, given its high upfront costs. Unfortunately, these programs are presently limited to select locations around the country. By calling attention to these innovative initiatives, this report aims to help policy makers consider greater adoption of these models to benefit homeowners interested installing a residential PV system.

  19. Utility Sector Impacts of Reduced Electricity Demand

    SciTech Connect

    Coughlin, Katie

    2014-12-01

    This report presents a new approach to estimating the marginal utility sector impacts associated with electricity demand reductions. The method uses publicly available data and provides results in the form of time series of impact factors. The input data are taken from the Energy Information Agency's Annual Energy Outlook (AEO) projections of how the electric system might evolve in the reference case, and in a number of side cases that incorporate different effciency and other policy assumptions. The data published with the AEO are used to define quantitative relationships between demand-side electricity reductions by end use and supply-side changes to capacity by plant type, generation by fuel type and emissions of CO2, Hg, NOx and SO2. The impact factors define the change in each of these quantities per unit reduction in site electricity demand. We find that the relative variation in these impacts by end use is small, but the time variation can be significant.

  20. Search for Dark Sector at BESIII

    NASA Astrophysics Data System (ADS)

    Guo, Yuping

    The BESIII experiment, a low-energy high-intensity frontier running in tau-charm energy region, provides good opportunity for the search of the exotic particles predicted in new physics models in dark sector scenario. Using data samples taken at the peak of J/ψ, ψ(2S), and ψ(3770), some of the highlights including the search for the dark photon using initial state radiation reactions e+e- → γISRe+e- and e+e- → γISRμ+μ-, the search for CP-odd light Higgs boson A0 in J/ψ → γA0, and the search for invisible decays of η and η' are presented.

  1. Long-term migration of the solar sector structure

    NASA Technical Reports Server (NTRS)

    Wolff, C. L.; Heath, D. F.

    1979-01-01

    The magnetic sector boundaries on the sun and in the solar wind are shown to have a high correlation with winter low pressure systems on earth. The vorticity-area index typically declines by about 10% during several days centered on the time when a sector boundary sweeps past the earth. Evidence that both the sector structure and solar activity levels can be understood as being under the influence of the same regular, internal solar mechanism is presented.

  2. The interplanetary and solar magnetic field sector structures, 1962 - 1968

    NASA Technical Reports Server (NTRS)

    Jones, D. E.

    1972-01-01

    The interplanetary magnetic field sector structure was observed from late 1962 through 1968. During this time it has been possible to study the manner in which the sector pattern and its relation to the photospheric magnetic field configuration changes from solar minimum to solar maximum. Observations were also made relating sector boundaries to specific regions on the solar disk. These and other observations related to the solar origin of the interplanetary field are briefly reviewed.

  3. Discovering Preferential Patterns in Sectoral Trade Networks

    PubMed Central

    Cingolani, Isabella; Piccardi, Carlo; Tajoli, Lucia

    2015-01-01

    We analyze the patterns of import/export bilateral relations, with the aim of assessing the relevance and shape of “preferentiality” in countries’ trade decisions. Preferentiality here is defined as the tendency to concentrate trade on one or few partners. With this purpose, we adopt a systemic approach through the use of the tools of complex network analysis. In particular, we apply a pattern detection approach based on community and pseudocommunity analysis, in order to highlight the groups of countries within which most of members’ trade occur. The method is applied to two intra-industry trade networks consisting of 221 countries, relative to the low-tech “Textiles and Textile Articles” and the high-tech “Electronics” sectors for the year 2006, to look at the structure of world trade before the start of the international financial crisis. It turns out that the two networks display some similarities and some differences in preferential trade patterns: they both include few significant communities that define narrow sets of countries trading with each other as preferential destinations markets or supply sources, and they are characterized by the presence of similar hierarchical structures, led by the largest economies. But there are also distinctive features due to the characteristics of the industries examined, in which the organization of production and the destination markets are different. Overall, the extent of preferentiality and partner selection at the sector level confirm the relevance of international trade costs still today, inducing countries to seek the highest efficiency in their trade patterns. PMID:26485163

  4. Characterizing the development of sectoral gross domestic product composition.

    PubMed

    Lutz, Raphael; Spies, Michael; Reusser, Dominik E; Kropp, Jürgen P; Rybski, Diego

    2013-07-01

    We consider the sectoral composition of a country's gross domestic product (GDP), i.e., the partitioning into agrarian, industrial, and service sectors. Exploring a simple system of differential equations, we characterize the transfer of GDP shares between the sectors in the course of economic development. The model fits for the majority of countries providing four country-specific parameters. Relating the agrarian with the industrial sector, a data collapse over all countries and all years supports the applicability of our approach. Depending on the parameter ranges, country development exhibits different transfer properties. Most countries follow three of eight characteristic paths. The types are not random but show distinct geographic and development patterns.

  5. Conic sectors for sampled-data feedback systems

    NASA Technical Reports Server (NTRS)

    Thompson, P. M.; Stein, G.; Athans, M.

    1983-01-01

    The conic-sector analysis of the closed-loop stability and robustness of a multivariable-analog-system controller based on sampled-data feedback compensation is investigated. Conic sectors and sampled-data feedback systems are defined, and the existence of a conic sector containing a sampled-data operator is established mathematically. An example is presented to prove that the conic sector is computable and gives sufficient conditions of closed-loop stability. A procedure for determining sampled-data-operator gain is also derived.

  6. Reheating the Standard Model from a hidden sector

    NASA Astrophysics Data System (ADS)

    Tenkanen, Tommi; Vaskonen, Ville

    2016-10-01

    We consider a scenario where the inflaton decays to a hidden sector thermally decoupled from the visible Standard Model sector. A tiny portal coupling between the hidden and the visible sectors later heats the visible sector so that the Standard Model degrees of freedom come to dominate the energy density of the Universe before big bang nucleosynthesis. We find that this scenario is viable, although obtaining the correct dark matter abundance and retaining successful big bang nucleosynthesis is not obvious. We also show that the isocurvature perturbations constituted by a primordial Higgs condensate are not problematic for the viability of the scenario.

  7. Synthesis and structure of In(IO{sub 3}){sub 3} and vibrational spectroscopy of M(IO{sub 3}){sub 3} (M=Al, Ga, In)

    SciTech Connect

    Ngo, Nhan; Kalachnikova, Katrina; Assefa, Zerihun; Haire, Richard G.; Sykora, Richard E. . E-mail: rsykora@jaguar1.usouthal.edu

    2006-12-15

    The reaction of Al, Ga, or In metals and H{sub 5}IO{sub 6} in aqueous media at 180{sup o}C leads to the formation of Al(IO{sub 3}){sub 3}, Ga(IO{sub 3}){sub 3,} or In(IO{sub 3}){sub 3}, respectively. Single-crystal X-ray diffraction experiments have shown In(IO{sub 3}){sub 3} contains the Te{sub 4}O{sub 9}-type structure, while both Al(IO{sub 3}){sub 3} and Ga(IO{sub 3}){sub 3} are known to exhibit the polar Fe(IO{sub 3}){sub 3}-type structure. Crystallographic data for In(IO{sub 3}){sub 3}, trigonal, space group R3-bar , a=9.7482(4)A, c=14.1374(6)A, V=1163.45(8) Z=6, R(F)=1.38% for 41 parameters with 644 reflections with I>2{sigma}(I). All three iodate structures contain group 13 metal cations in a distorted octahedral coordination environment. M(IO{sub 3}){sub 3} (M=Al, Ga) contain a three-dimensional network formed by the bridging of Al{sup 3+} or Ga{sup 3+} cations by iodate anions. With In(IO{sub 3}){sub 3}, iodate anions bridge In{sup 3+} cations in two-dimensional layers. Both materials contain distorted octahedral holes in their structures formed by terminal oxygen atoms from the iodate anions. The Raman spectra have been collected for these metal iodates; In(IO{sub 3}){sub 3} was found to display a distinctively different vibrational profile than Al(IO{sub 3}){sub 3} or Ga(IO{sub 3}){sub 3}. Hence, the Raman profile can be used as a rapid diagnostic tool to discern between the different structural motifs.

  8. Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1-24 Months in the MAL-ED Study.

    PubMed

    McCormick, Benjamin J J; Lee, Gwenyth O; Seidman, Jessica C; Haque, Rashidul; Mondal, Dinesh; Quetz, Josiane; Lima, Aldo A M; Babji, Sudhir; Kang, Gagandeep; Shrestha, Sanjaya K; Mason, Carl J; Qureshi, Shahida; Bhutta, Zulfiqar A; Olortegui, Maribel Paredes; Yori, Pablo Peñataro; Samie, Amidou; Bessong, Pascal; Amour, Caroline; Mduma, Estomih; Patil, Crystal L; Guerrant, Richard L; Lang, Dennis R; Gottlieb, Michael; Caulfield, Laura E; Kosek, Margaret N

    2017-02-08

    Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from fecal samples collected during the first 2 years of each child's life. A total of 22,846 stool samples were processed during the longitudinal sampling of 2,076 children 0-24 months of age. Linear mixed models were constructed to examine the relationship between biomarker concentrations and recent food intake, symptoms of illness, concurrent enteropathogen infection, and socioeconomic status. Average concentrations of MPO, NEO, and AAT were considerably higher than published references for healthy adults. The concentration of each biomarker tended to decrease over the first 2 years of life and was highly variable between samples from each individual child. Both MPO and AAT were significantly elevated by recent breast milk intake. All three biomarkers were associated with pathogen presence, although the strength and direction varied by pathogen. The interpretation of biomarker concentrations is subject to the context of their collection. Herein, we identify that common factors (age, breast milk, and enteric infection) influence the concentration of these biomarkers. Within the context of low- and middle-income communities, we observe concentrations that indicate gut abnormalities, but more appropriate reference standards are needed.

  9. Establishment of novel in vitro mouse chief cell and SPEM cultures identifies MAL2 as a marker of metaplasia in the stomach.

    PubMed

    Weis, Victoria G; Petersen, Christine P; Mills, Jason C; Tuma, Pamela L; Whitehead, Robert H; Goldenring, James R

    2014-10-15

    Oxyntic atrophy in the stomach leads to chief cell transdifferentiation into spasmolytic polypeptide expressing metaplasia (SPEM). Investigations of preneoplastic metaplasias in the stomach are limited by the sole reliance on in vivo mouse models, owing to the lack of in vitro models for distinct normal mucosal lineages and metaplasias. Utilizing the Immortomouse, in vitro cell models of chief cells and SPEM were developed to study the characteristics of normal chief cells and metaplasia. Chief cells and SPEM cells isolated from Immortomice were cultured and characterized at both the permissive (33°C) and the nonpermissive temperature (39°C). Clones were selected on the basis of their transcriptional expression of specific stomach lineage markers (named ImChief and ImSPEM) and protein expression and growth were analyzed. The transcriptional expression profiles of ImChief and ImSPEM cells were compared further by using gene microarrays. ImChief cells transcriptionally express most chief cell markers and contain pepsinogen C and RAB3D-immunostaining vesicles. ImSPEM cells express the SPEM markers TFF2 and HE4 and constitutively secrete HE4. Whereas ImChief cells cease proliferation at the nonpermissive temperature, ImSPEM cells continue to proliferate at 39°C. Gene expression profiling of ImChief and ImSPEM revealed myelin and lymphocyte protein 2 (MAL2) as a novel marker of SPEM lineages. Our results indicate that the expression and proliferation profiles of the novel ImChief and ImSPEM cell lines resemble in vivo chief and SPEM cell lineages. These cell culture lines provide the first in vitro systems for studying the molecular mechanisms of the metaplastic transition in the stomach.

  10. Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study

    PubMed Central

    Amour, Caroline; Gratz, Jean; Mduma, Estomih; Svensen, Erling; Rogawski, Elizabeth T.; McGrath, Monica; Seidman, Jessica C.; McCormick, Benjamin J. J.; Shrestha, Sanjaya; Samie, Amidou; Mahfuz, Mustafa; Qureshi, Shahida; Hotwani, Aneeta; Babji, Sudhir; Trigoso, Dixner Rengifo; Lima, Aldo A. M.; Bodhidatta, Ladaporn; Bessong, Pascal; Ahmed, Tahmeed; Shakoor, Sadia; Kang, Gagandeep; Kosek, Margaret; Guerrant, Richard L.; Lang, Dennis; Gottlieb, Michael; Houpt, Eric R.; Platts-Mills, James A.

    2016-01-01

    Background. Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life. Methods. Children were actively followed up until 24 months of age. Diarrheal and nondiarrheal stool samples were collected and tested by enzyme immunoassay for Campylobacter. Stool and blood samples were assayed for markers of intestinal permeability and inflammation. Results. A total of 1892 children had 7601 diarrheal and 26 267 nondiarrheal stool samples tested for Campylobacter. We describe a high prevalence of infection, with most children (n = 1606; 84.9%) having a Campylobacter-positive stool sample by 1 year of age. Factors associated with a reduced risk of Campylobacter detection included exclusive breastfeeding (risk ratio, 0.57; 95% confidence interval, .47–.67), treatment of drinking water (0.76; 0.70–0.83), access to an improved latrine (0.89; 0.82–0.97), and recent macrolide antibiotic use (0.68; 0.63–0.74). A high Campylobacter burden was associated with a lower length-for-age Z score at 24 months (−1.82; 95% confidence interval, −1.94 to −1.70) compared with a low burden (−1.49; −1.60 to −1.38). This association was robust to confounders and consistent across sites. Campylobacter infection was also associated with increased intestinal permeability and intestinal and systemic inflammation. Conclusions. Campylobacter was prevalent across diverse settings and associated with growth shortfalls. Promotion of exclusive breastfeeding, drinking water treatment, improved latrines, and targeted antibiotic treatment may reduce the burden of Campylobacter infection and improve growth in children in these settings. PMID:27501842

  11. Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1–24 Months in the MAL-ED Study

    PubMed Central

    McCormick, Benjamin J. J.; Lee, Gwenyth O.; Seidman, Jessica C.; Haque, Rashidul; Mondal, Dinesh; Quetz, Josiane; Lima, Aldo A. M.; Babji, Sudhir; Kang, Gagandeep; Shrestha, Sanjaya K.; Mason, Carl J.; Qureshi, Shahida; Bhutta, Zulfiqar A.; Olortegui, Maribel Paredes; Yori, Pablo Peñataro; Samie, Amidou; Bessong, Pascal; Amour, Caroline; Mduma, Estomih; Patil, Crystal L.; Guerrant, Richard L.; Lang, Dennis R.; Gottlieb, Michael; Caulfield, Laura E.; Kosek, Margaret N.

    2017-01-01

    Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from fecal samples collected during the first 2 years of each child's life. A total of 22,846 stool samples were processed during the longitudinal sampling of 2,076 children 0–24 months of age. Linear mixed models were constructed to examine the relationship between biomarker concentrations and recent food intake, symptoms of illness, concurrent enteropathogen infection, and socioeconomic status. Average concentrations of MPO, NEO, and AAT were considerably higher than published references for healthy adults. The concentration of each biomarker tended to decrease over the first 2 years of life and was highly variable between samples from each individual child. Both MPO and AAT were significantly elevated by recent breast milk intake. All three biomarkers were associated with pathogen presence, although the strength and direction varied by pathogen. The interpretation of biomarker concentrations is subject to the context of their collection. Herein, we identify that common factors (age, breast milk, and enteric infection) influence the concentration of these biomarkers. Within the context of low- and middle-income communities, we observe concentrations that indicate gut abnormalities, but more appropriate reference standards are needed. PMID:27994110

  12. Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)

    SciTech Connect

    Morita, Tsuyoshi; Mayanagi, Taira; Sobue, Kenji

    2007-10-01

    RhoA is a crucial regulator of stress fiber and focal adhesion formation through the activation of actin nucleation and polymerization. It also regulates the nuclear translocation of myocardin-related transcription factor-A and -B (MRTF-A/B, MAL or MKL 1/2), which are co-activators of serum response factor (SRF). In dominant-negative MRTF-A (DN-MRTF-A)-expressing NIH 3T3 cell lines, the expressions of several cytoskeletal/focal adhesion genes were down-regulated, and the formation of stress fiber and focal adhesion was severely diminished. MRTF-A/B-knockdown cells also exhibited such cytoskeletal defects. In reporter assays, both RhoA and MRTF-A enhanced promoter activities of these genes in a CArG-box-dependent manner, and DN-MRTF-A inhibited the RhoA-mediated activation of these promoters. In dominant-negative RhoA (RhoA-N19)-expressing NIH 3T3 cell lines, the nuclear translocation of MRTF-A/B was predominantly prevented, resulting in the reduced expression of cytoskeletal/focal adhesion proteins. Further, constitutive-active MRTF-A/B increased the expression of endogenous cytoskeletal/focal adhesion proteins, and thereby rescued the defective phenotype of stress fibers and focal adhesions in RhoA-N19 expressing cells. These results indicate that MRTF-A/B act as pivotal mediators of stress fiber and focal adhesion formation via the transcriptional regulation of a subset of cytoskeletal/focal adhesion genes.

  13. Public-Sector Information Security: A Call to Action for Public-Sector CIOs

    DTIC Science & Technology

    2007-11-02

    Objectives ........................14 Recommendation 4: Develop Security Metrics ............................16 Recommendation 5 : Develop Enterprise-IT...us, especially if they understand it better than we do.… 4. They will attack the seams of our technology infrastructure.… 5 . Our technology, like our...sure unwanted intrusions, security breaches, penetrations, and vulnerabilities. The reporting E X E C U T I V E S U M M A R Y 5 PUBLIC-SECTOR

  14. 75 FR 70725 - Spectrum Policy Seminar for the Utility Sector

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-18

    ... Spectrum Policy Seminar for the Utility Sector AGENCY: Department of Energy. ACTION: Notice of public... . One recommendation in the report was to provide more information to the utility sector on spectrum... grid technologies. At this spectrum policy seminar, senior officials from the Federal...

  15. Sector Growth Demonstration in the Chesapeake Bay Watershed

    EPA Pesticide Factsheets

    EPA continues to work with the Bay states and DC to adress areas of concern identified in the final reports. EPA has asked each state and DC to prepare a Sector Load Growth Demonstration using the Sector Load Growth techical memorandum as a guide.

  16. Reflections on the Tertiary Education Sector in Australia. Conference Paper

    ERIC Educational Resources Information Center

    Karmel, Tom

    2009-01-01

    The split between higher education and vocational education and training (VET) in Australia is not clean. This paper discusses a number of aspects of this tertiary education sector: the Australian Qualifications Framework (AQF), which describes the qualifications offered by the three education sectors: schools, higher education and VET; student…

  17. General view of Sector Four Compound, looking north. Antenna Array ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General view of Sector Four Compound, looking north. Antenna Array is in background, behind Communications Antennas, Receiver Building, and Water Storage Tank - Over-the-Horizon Backscatter Radar Network, Tulelake Radar Site Receive Sector Four Antenna Array, Unnamed Road West of Double Head Road, Tulelake, Siskiyou County, CA

  18. 50 CFR 270.14 - Update of sector participant data.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Update of sector participant data. 270.14 Section 270.14 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... § 270.14 Update of sector participant data. The Council will submit to NMFS at the end of each...

  19. 50 CFR 270.14 - Update of sector participant data.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Update of sector participant data. 270.14 Section 270.14 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... § 270.14 Update of sector participant data. The Council will submit to NMFS at the end of each...

  20. 50 CFR 270.14 - Update of sector participant data.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Update of sector participant data. 270.14 Section 270.14 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... § 270.14 Update of sector participant data. The Council will submit to NMFS at the end of each...

  1. 50 CFR 270.14 - Update of sector participant data.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Update of sector participant data. 270.14 Section 270.14 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... § 270.14 Update of sector participant data. The Council will submit to NMFS at the end of each...

  2. Probing the non-minimal Higgs sector at the SSC

    SciTech Connect

    Gunion, J.F.; Haber, H.E.; Komamiya, S.; Yamamoto, H.; Barbaro-Galtieri, A.

    1987-11-01

    Non-minimal Higgs sectors occur in the Standard Model with more than one Higgs doublet, as well as in theories that go beyond the Standard Model. In this report, we discuss how Higgs search strategies must be altered, with respect to the Standard Model approaches, in order to probe the non-minimal Higgs sectors at the SSC.

  3. Pay Premiums for Economic Sector and Race: A Decomposition.

    ERIC Educational Resources Information Center

    Daymont, Thomas N.

    Using data from the older men's file of the National Longitudinal Surveys, two issues related to the labor market implications of dual economy theory were examined: variations in rates of pay among economic sectors (competitive, monopoly, and public) and variation in relative opportunities for blacks across sectors. The primary analytical problem…

  4. General view of Sector Six Compound, looking east. Water Storage ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General view of Sector Six Compound, looking east. Water Storage Tank is at left - Over-the-Horizon Backscatter Radar Network, Tulelake Radar Site Receive Sector Six Water Storage Plant, Unnamed Road West of Double Head Road, Tulelake, Siskiyou County, CA

  5. Oblique view of Sector Five Compound, looking southwest. Water Tank ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Oblique view of Sector Five Compound, looking southwest. Water Tank to right, Receiver Building to left, antenna array in background - Over-the-Horizon Backscatter Radar Network, Tulelake Radar Site Receive Sector Five Water Storage Tank, Unnamed Road West of Double Head Road, Tulelake, Siskiyou County, CA

  6. Oblique view of Sector Four Compound, looking southwest. Water Storage ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Oblique view of Sector Four Compound, looking southwest. Water Storage Tank in center behind fence, in front of Receiver Building - Over-the-Horizon Backscatter Radar Network, Tulelake Radar Site Receive Sector Four Water Storage Facility, Unnamed Road West of Double Head Road, Tulelake, Siskiyou County, CA

  7. General view of Sector Four Compound looking northwest. Water Storage ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General view of Sector Four Compound looking northwest. Water Storage Tank is at right, Receiver Building in center, and Communications Antennas at left - Over-the-Horizon Backscatter Radar Network, Tulelake Radar Site Receive Sector Four Water Storage Facility, Unnamed Road West of Double Head Road, Tulelake, Siskiyou County, CA

  8. Adults with Cognitive Disabilities in the Technical Sector

    ERIC Educational Resources Information Center

    Gronsky, Stacy A.

    2015-01-01

    Given the number of jobs created in the technical sector (Casserly, 2012), it is essential to identify how adults with cognitive disabilities can be best supported in professional environments and evolving sectors. Some career paths and jobs can be more understanding of learning disabilities than others (Nicholas, 2011). This is dependent not only…

  9. Gearing Up: An Interim Report on the Sectoral Employment Initiative.

    ERIC Educational Resources Information Center

    Elliott, Mark; Roder, Anne; King, Elisabeth; Stillman, Joseph

    A study assessed the first two years of a three-year initiative to test the potential of extending sectoral employment strategies among 10 organizations, most of which were new to the sectoral employment field. Five organizations increasing low-income workers' access to good jobs were ARCH; PhAME; Training, Inc.; WIRE-Net; and Project QUEST. Five…

  10. A Guide to Discipline in the Public Sector.

    ERIC Educational Resources Information Center

    Seidman, Joel

    This monograph was prepared as an initial effort in development of a body of material for training public sector managers. It sets forth the basic principles of grievance arbitration covering discipline in the public sector. Major sections are devoted to the topics of just or proper cause for discipline, due process, the nature of discipline, and…

  11. Wage Gaps Between the Public and Private Sectors in Spain.

    ERIC Educational Resources Information Center

    Lassibille, Gerard

    1998-01-01

    Estimates separate earnings equations by employment sector and gender in Spain and identifies returns to human capital, based on 1990-91 household survey data. Public wages are higher, and civil servants more highly educated. However, the public sector pays lower returns to education and experience. Earnings advantage is largest for least skilled…

  12. Foreign direct investment in the electricity sector: the Indian perspective

    SciTech Connect

    Sharma, A.K.; Vohra, Ekta

    2008-08-15

    So far, India is losing out in the competition against other emerging economies to attract more foreign direct investment to its electricity sector. This is in large part because the Indian approach towards power sector reforms is more haphazard than the more orderly and sensitive growth model of Singapore and Latin American economies. (author)

  13. Electric power sector in Mexico: Past, present, and future developments

    SciTech Connect

    Arriola, E. )

    1994-06-01

    This article reviews electric power sector development in Mexico. The topics of the article include the historic aspects of the development of a national interconnected system, current power demand and system capacity, electric energy exports and imports, expected growth and generation projects under construction, and future development of the electric power sector under the new law.

  14. 21 CFR 26.72 - Sectoral contact points.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Sectoral contact points. 26.72 Section 26.72 Food...Frameworkâ Provisions § 26.72 Sectoral contact points. Each party shall appoint and confirm in writing contact points to be responsible for activities under subparts A and B of this part....

  15. 21 CFR 26.72 - Sectoral contact points.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Sectoral contact points. 26.72 Section 26.72 Food...Frameworkâ Provisions § 26.72 Sectoral contact points. Each party shall appoint and confirm in writing contact points to be responsible for activities under subparts A and B of this part....

  16. 21 CFR 26.72 - Sectoral contact points.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Sectoral contact points. 26.72 Section 26.72 Food...Frameworkâ Provisions § 26.72 Sectoral contact points. Each party shall appoint and confirm in writing contact points to be responsible for activities under subparts A and B of this part....

  17. 21 CFR 26.72 - Sectoral contact points.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Sectoral contact points. 26.72 Section 26.72 Food...Frameworkâ Provisions § 26.72 Sectoral contact points. Each party shall appoint and confirm in writing contact points to be responsible for activities under subparts A and B of this part....

  18. 21 CFR 26.72 - Sectoral contact points.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Sectoral contact points. 26.72 Section 26.72 Food...Frameworkâ Provisions § 26.72 Sectoral contact points. Each party shall appoint and confirm in writing contact points to be responsible for activities under subparts A and B of this part....

  19. Sector Distinctions and the Privatization of Public Education Policymaking

    ERIC Educational Resources Information Center

    Lubienski, Christopher

    2016-01-01

    Current trends indicate declining distinctions between "public" and "private" sectors in education. Reformers see sector barriers as unnecessary impediments to innovation, distracting attention and effort from "what works". This analysis questions whether trends in education policy are simply a natural evolution away…

  20. Accelerators in various sectors of the world economy

    NASA Astrophysics Data System (ADS)

    Chernyaev, A. P.; Varzar', S. M.; Borschegovskaya, P. Y.; Belousov, A. V.; Bliznyuk, U. A.

    2016-12-01

    Ionizing radiation is widely being used in medicine and agricultural and industrial sectors. Its sources are X-ray tubes, natural and manmade isotopes, and accelerators. This paper presents data on accelerator facilities operating in various sectors of the world economy.

  1. Quality in the Australian VET Sector: What Has Been Happening?

    ERIC Educational Resources Information Center

    Harris, Roger

    2015-01-01

    VET (vocational education and training) is a fascinating sector. Aligned closely with the labour market and sandwiched between two major sectors, it is continually buffeted by political winds, susceptible to the ideologies of different governments. Often labelled the "poor cousin", debates continue to rage about its quality. This paper…

  2. Partnerships with the Public Sector: Vocational Education Resource Package.

    ERIC Educational Resources Information Center

    Evaluation and Training Inst., Los Angeles, CA.

    Designed to assist community college administrators and faculty in enhancing vocational education programs and services, this resource package contains information on successful partnership programs between California Community Colleges (CCC) and public sector entities. Following a brief overview of public sector partnerships, the report presents…

  3. ICT and Web Technology Based Innovations in Education Sector

    ERIC Educational Resources Information Center

    Sangeeta Namdev, Dhamdhere

    2012-01-01

    ICT made real magic and drastic changes in all service sectors along with higher education and library practices and services. The academic environment is changing from formal education to distance and online learning mode because of ICT. Web technology and mobile technology has made great impact on education sector. The role of Open Access,…

  4. Convective Weather Forecast Accuracy Analysis at Center and Sector Levels

    NASA Technical Reports Server (NTRS)

    Wang, Yao; Sridhar, Banavar

    2010-01-01

    This paper presents a detailed convective forecast accuracy analysis at center and sector levels. The study is aimed to provide more meaningful forecast verification measures to aviation community, as well as to obtain useful information leading to the improvements in the weather translation capacity models. In general, the vast majority of forecast verification efforts over past decades have been on the calculation of traditional standard verification measure scores over forecast and observation data analyses onto grids. These verification measures based on the binary classification have been applied in quality assurance of weather forecast products at the national level for many years. Our research focuses on the forecast at the center and sector levels. We calculate the standard forecast verification measure scores for en-route air traffic centers and sectors first, followed by conducting the forecast validation analysis and related verification measures for weather intensities and locations at centers and sectors levels. An approach to improve the prediction of sector weather coverage by multiple sector forecasts is then developed. The weather severe intensity assessment was carried out by using the correlations between forecast and actual weather observation airspace coverage. The weather forecast accuracy on horizontal location was assessed by examining the forecast errors. The improvement in prediction of weather coverage was determined by the correlation between actual sector weather coverage and prediction. observed and forecasted Convective Weather Avoidance Model (CWAM) data collected from June to September in 2007. CWAM zero-minute forecast data with aircraft avoidance probability of 60% and 80% are used as the actual weather observation. All forecast measurements are based on 30-minute, 60- minute, 90-minute, and 120-minute forecasts with the same avoidance probabilities. The forecast accuracy analysis for times under one-hour showed that the errors in

  5. The impact of oil price on Malaysian sector indices

    NASA Astrophysics Data System (ADS)

    Ismail, Mohd Tahir; Luan, Yeap Pei; Ee, Ong Joo

    2015-12-01

    In this paper, vector error correction model (VECM) has been utilized to model the dynamic relationships between world crude oil price and the sector indices of Malaysia. The sector indices have been collected are covering the period Jan 1998 to Dec 2013. Surprisingly, our investigations show that oil price changes do not Granger-cause any of the sectors in all of Malaysia. However, sector indices of Food Producer and Utilities are found to be the cause of the changes in world crude oil prices. Furthermore, from the results of variance decomposition, very high percentage of shocks is explained by world crude oil price itself over the 12 months and small impact from other sector indices.

  6. The Mexican petrochemical sector in the NAFTA negotiations

    SciTech Connect

    Kessel, G.; Kim, C.S.

    1993-12-31

    Since 1985, there have been important changes in the Mexican petrochemical sector, including trade liberalization, deregulation and the elimination of subsidies. NAFTA represents another step towards liberalization of the sector. Given the low tariffs currently applied to international trade among the three nations, the authors do not anticipate major impacts of NAFTA on trade flows. Nevertheless, the elimination of restrictions to foreign investment is expected to increase capital flows into the sector and to promote productivity increases. On the other hand, the new barriers to trade in petrochemical feedstocks and the restrictions on private investment in infrastructure may negatively affect the sector`s growth, making it necessary to adjust domestic regulations to improve the performance of Pemex. 12 refs., 4 tabs.

  7. How to Effect Change Through Cross-sector Collaboration

    NASA Astrophysics Data System (ADS)

    Ellis, R.; Elinich, K.; Johnson, R.; Allen, L. B.; Crowley, K. J.; Bachrach, E.

    2014-12-01

    Collaboration is important for effecting large-scale changes, but it is difficult, time-consuming, and requires sustained effort on the part of all collaborating parties. Collaboration among organizations within a single sector (education, policy, or advocacy, for example) is easier than collaboration across sectors, where differences in language, expertise, expectations, and goals can be barriers to shared outcomes. Improving our collective response to climate change is an outcome shared across sectors, providing an opportunity for cross-sector collaboration. The Climate and Urban System Partnership is a network of cross-sector organizations in four cities, with each city forming a local Community of Practice, a group of learners coming together to try new things and learn from each other. We present findings from the first two years of this CCEP-II project, including results from learning sciences, evaluation, and design studies in Pittsburgh, New York, Washington, DC, and Philadelphia.

  8. Venus ionopause 'clouds' and IMF sector boundaries

    NASA Astrophysics Data System (ADS)

    Luhmann, Janet G.; Russell, C. T.; Wei, Hanying; Ma, Yingjuan; Zhang, Tielong; McEnulty, T.

    Disconnected or partially connected structures observed by the PVO Langmuir Probe near the ionopause of Venus were called 'clouds' by Brace et al. (1980). These authors speculated that the loss of atmosphere represented by these features could be significant compared to other loss processes. Russell et al. (1982) subsequently showed that the clouds occurred together with sharp rotations in the magnetic field. They suggested that the extreme draping of the interplanetary field that occurs near the ionopause at the draping poles could exert JxB forces sufficient to pull the ionospheric plasma in the cloud tailward and out into the heliosphere. But in 1991, Ong et al. demonstrated via analysis of many clouds that they are not generally seen in the polar regions of the draped magnetosheath field. Instead they occur at times when the interplanetary magnetic field undergoes a sudden rotation, as in interplanetary field sector boundaries. We discuss the statistics of such rotations at the orbit of Venus and their frequency as a function of solar cycle. Whether they enable or enhance escape or not requires simulation studies, but this study calls attention to the potential importance of time dependent external conditions.

  9. Alignment limit of the NMSSM Higgs sector

    DOE PAGES

    Carena, Marcela; Haber, Howard E.; Low, Ian; ...

    2016-02-17

    The Next-to-Minimal Supersymmetric extension of the Standard Model (NMSSM) with a Higgs boson of mass 125 GeV can be compatible with stop masses of order of the electroweak scale, thereby reducing the degree of fine-tuning necessary to achieve electroweak symmetry breaking. Moreover, in an attractive region of the NMSSM parameter space, corresponding to the \\alignment limit" in which one of the neutral Higgs fields lies approximately in the same direction in field space as the doublet Higgs vacuum expectation value, the observed Higgs boson is predicted to have Standard- Model-like properties. We derive analytical expressions for the alignment conditions andmore » show that they point toward a more natural region of parameter space for electroweak symmetry breaking, while allowing for perturbativity of the theory up to the Planck scale. Additionally, the alignment limit in the NMSSM leads to a well defined spectrum in the Higgs and Higgsino sectors, and yields a rich and interesting Higgs boson phenomenology that can be tested at the LHC. Here, we discuss the most promising channels for discovery and present several benchmark points for further study.« less

  10. Alignment limit of the NMSSM Higgs sector

    SciTech Connect

    Carena, Marcela; Haber, Howard E.; Low, Ian; Shah, Nausheen R.; Wagner, Carlos E. M.

    2016-02-17

    The Next-to-Minimal Supersymmetric extension of the Standard Model (NMSSM) with a Higgs boson of mass 125 GeV can be compatible with stop masses of order of the electroweak scale, thereby reducing the degree of fine-tuning necessary to achieve electroweak symmetry breaking. Moreover, in an attractive region of the NMSSM parameter space, corresponding to the \\alignment limit" in which one of the neutral Higgs fields lies approximately in the same direction in field space as the doublet Higgs vacuum expectation value, the observed Higgs boson is predicted to have Standard- Model-like properties. We derive analytical expressions for the alignment conditions and show that they point toward a more natural region of parameter space for electroweak symmetry breaking, while allowing for perturbativity of the theory up to the Planck scale. Additionally, the alignment limit in the NMSSM leads to a well defined spectrum in the Higgs and Higgsino sectors, and yields a rich and interesting Higgs boson phenomenology that can be tested at the LHC. Here, we discuss the most promising channels for discovery and present several benchmark points for further study.

  11. Latin American petroleum sector at crossroads

    SciTech Connect

    Williams, B.

    1992-07-06

    This paper reports that Latin America's petroleum industry stands at a precarious crossroads of change. Fundamental changes of democratization, privatization, and economic reform that have marked South America's petroleum sectors since the late 1980s are seeping into other Latin American regions. An unprecedented return of capital that had fled the region in the 1980s - Latin America's lost decade - is under way in full force. That demonstrates the improved credibility of the region's economic reform programs, reports the Inter-American Development Bank (IDB). Even as those reform efforts marked progress in South America in 1991, however, that progress has been threatened in 1992 by political scandal, government crisis, and environmental controversy. Just as the fitful transition to capitalism in the former U.S.S.R. has threatened to collapse the former Soviet republics into chaos because of its economic fallout, so has economic reform in such nations as Brazil, Peru, and Venezuela stumbled. On the other hand, privatization continues apace in Argentina and Mexico. Those Latin American nations and others caught in the rising tide of privatization pulled by an increasingly market oriented global economy continue to avow their commitment to economic reform.

  12. Employment of Geoscientists in the Private Sector

    NASA Astrophysics Data System (ADS)

    Russell, J. L.

    2001-05-01

    In the private sector, major employers of geoscientists engage in diverse activities ranging from resource exploration and extraction, assessment of geologic hazards, and determination of environmental impacts. These firms actively recruit, from the breadth of geoscience disciplines, technically qualified individuals with the ability to make pragmatic decisions in the context of multidisciplinary teams that commonly include non-scientists. Moreover, they expect applicants to communicate effectively verbally and in writing, as well as demonstrate skills and experience in integrating field investigations, conducting laboratory studies, and accomplishing computer modeling. These applicants should be capable of simultaneously working in multiple projects which are rapidly evolving. Successful recruiting and employment requires interactions between the job applicant and potential employer conducted with honesty and integrity. Resumes and associated transmittal letters should be directed to specific employers based on the applicant's review of information on the firm from the Internet and other sources. "Shotgun" or blanket approaches are seldom productive. Participation in pertinent professional societies, internships, and summer employment can provide valuable experiences and opportunities for networking with potential employers.

  13. Alternate-Fueled Combustor-Sector Emissions

    NASA Technical Reports Server (NTRS)

    Saxena, Nikita T.; Thomas, Anna E.; Shouse, Dale T.; Neuroth, Craig; Hendricks, Robert C.; Lynch, Amy; Frayne, Charles W.; Stutrud, Jeffrey S.; Corporan, Edwin; Hankins, Terry

    2013-01-01

    In order to meet rapidly growing demand for fuel, as well as address environmental concerns, the aviation industry has been testing alternate fuels for performance and technical usability in commercial and military aircraft. In order to make alternate fuels (and blends) a viable option for aviation, the fuel must be able to perform at a similar or higher level than traditional petroleum fuel. They also attempt to curb harmful emissions, and therefore a truly effective alternate fuel would emit at or under the level of currently used fuel. This report analyzes data from gaseous and particulate emissions of an aircraft combustor sector. The data were evaluated at various inlet conditions, including variation in pressure and temperature, fuel-to-air ratios, and percent composition of alternate fuel. Traditional JP-8+100 data were taken as a baseline, and blends of JP-8+100 with synthetic-paraffinic-kerosene (SPK) fuel (Fischer-Tropsch (FT)) were used for comparison. Gaseous and particulate emissions, as well as flame luminosity, were assessed for differences between FT composition of 0, 50, and 100 percent. The data show that SPK fuel (an FT-derived fuel) had slightly lower harmful gaseous emissions, and smoke number information corroborated the hypothesis that SPK-FT fuels are cleaner burning fuels.

  14. Antineutrino Oscillations in the Atmospheric Sector

    SciTech Connect

    Himmel, Alexander I.

    2011-05-01

    This thesis presents measurements of the oscillations of muon antineutrinos in the atmospheric sector, where world knowledge of antineutrino oscillations lags well behind the knowledge of neutrinos, as well as a search for vμ → $\\bar{v}$μ transitions. Differences between neutrino and antineutrino oscillations could be a sign of physics beyond the Standard Model, including non-standard matter interactions or the violation of CPT symmetry. These measurements leverage the sign-selecting capabilities of the magnetized steel-scintillator MINOS detectors to analyze antineutrinos from the NuMI beam, both when it is in neutrino-mode and when it is in antineutrino-mode. Antineutrino oscillations are observed at |Δ$\\bar{m}$atm 2| = (3.36-0.40+0.46(stat) ± 0.06(syst)) x 10-3 eV2 and sin2(2$\\bar{θ}$23) = 0.860-0.12+0.11(stat) ± 0.01(syst). The oscillation parameters measured for antineutrinos and those measured by MINOS for neutrinos differ by a large enough margin that the chance of obtaining two values as discrepant as those observed is only 2%, assuming the two measurements arise from the same underlying mechanism, with the same parameter values. No evidence is seen for neutrino-to-antineutrino transitions.

  15. Scenario development in China's electricity sector

    SciTech Connect

    Steenhof, P.A.; Fulton, W.

    2007-07-15

    The continuing growth of China's electricity sector will affect global environmental and economic sustainability due to its impacts on greenhouse gas emissions and global resource depletion. In 2005, the generation of electricity in China resulted in the emissions of 2290 million metric tonnes of carbon dioxide (approximately 53% of the nation's total) and required 779 million metric tonnes of coal (approximately 50% of China's total coal consumption). These figures are expected to increase with China's economic growth. In order to gauge the range in which fuel consumption and CO{sub 2} emissions could grow a scenario-based conceptual model has been developed by the authors (published in this journal). The application and analysis of this shows that under a business as usual (BAU) scenario, electricity generation could contribute upwards of 56% of China's energy related greenhouse gas emissions by 2020. Meanwhile, consumption of coal will also increase, growing to nearly 60% of total national demand by 2020. However, variations in a number of key drivers could produce significant deviation from the BAU scenario. With accelerated economic output, even with greater technological advances and greater potential to bring natural gas on stream, carbon dioxide emissions would rise 10% above the BAU. Alternatively, in a scenario where China's economy grows at a tempered pace, less investment would be available for advanced technologies, developing natural gas infrastructure, or nuclear energy. In this scenario, reduced economic growth and electricity demand would thereby be countered by reduced efficiency and a higher contribution of coal.

  16. Absence Seizure (Petit Mal Seizure)

    MedlinePlus

    ... Staff Absence seizures involve brief, sudden lapses of consciousness. They're more common in children than adults. ... have seizures, the brain's usual electrical activity is altered. During an absence seizure, these electrical signals repeat ...

  17. Focal mechanisms of micro-earthquakes in the Dobrá Voda seismoactive area in the Malé Karpaty Mts. (Little Carpathians), Slovakia

    NASA Astrophysics Data System (ADS)

    Fojtíková, Lucia; Vavryčuk, Václav; Cipciar, Andrej; Madarás Malé, Ján

    2010-09-01

    plunge downwards from the horizontal plane. The retrieved maximum compression lies along the belt of the Malé Karpaty Mts. The local tectonic stress reflects complex tectonic conditions in the area. The presence of tensile faulting might point to an extensional stress regime in the area.

  18. Fifteen years of sector-wide approach (SWAp) in Bangladesh health sector: an assessment of progress

    PubMed Central

    Ahsan, Karar Zunaid; Streatfield, Peter Kim; Ijdi, Rashida -E-; Escudero, Gabriela Maria; Khan, Abdul Waheed; Reza, M M

    2016-01-01

    The Ministry of Health and Family Welfare (MOHFW) of the Government of Bangladesh embarked on a sector-wide approach (SWAp) modality for the health, nutrition and population (HNP) sector in 1998. This programmatic shift initiated a different set of planning disciplines and practices along with institutional changes in the MOHFW. Over the years, the SWAp modality has evolved in Bangladesh as the MOHFW has learnt from its implementation and refined the program design. This article explores the progress made, both in terms of achievement of health outcomes and systems strengthening results, since the implementation of the SWAp for Bangladesh’s health sector. Secondary analyses of survey data from 1993 to 2011 as well as a literature review of published and grey literature on health SWAp in Bangladesh was conducted for this assessment. Results of the assessment indicate that the MOHFW made substantial progress in health outcomes and health systems strengthening. SWAps facilitated the alignment of funding and technical support around national priorities, and improved the government’s role in program design as well as in implementation and development partner coordination. Notable systemic improvements have taken place in the country systems with regards to monitoring and evaluation, procurement and service provision, which have improved functionality of health facilities to provide essential care. Implementation of the SWAp has, therefore, contributed to an accelerated improvement in key health outcomes in Bangladesh over the last 15 years. The health SWAp in Bangladesh offers an example of a successful adaptation of such an approach in a complex administrative structure. Based on the lessons learned from SWAp implementation in Bangladesh, the MOHFW needs to play a stronger stewardship and regulatory role to reap the full benefits of a SWAp in its subsequent programming. PMID:26582744

  19. Reduction of Eu{sup 3+} to Eu{sup 2+} in MAl{sub 2}Si{sub 2}O{sub 8} (M=Ca, Sr, Ba) in air condition

    SciTech Connect

    Zhang Cuimiao; Yang Jun; Lin Cuikun; Li Chunxia; Lin Jun

    2009-07-15

    In general, the reduction of Eu{sup 3+} to Eu{sup 2+} in solids needs an annealing process in a reducing atmosphere. In this paper, it is of great interest and importance to find that the reduction of Eu{sup 3+} to Eu{sup 2+} can be realized in a series of alkaline-earth metal aluminum silicates MAl{sub 2}Si{sub 2}O{sub 8} (M=Ca, Sr, Ba) just in air condition. The Eu{sup 2+}-doped MAl{sub 2}Si{sub 2}O{sub 8} (M=Ca, Sr, Ba) powder samples were prepared in air atmosphere by Pechini-type sol-gel process. It was found that the strong band emissions of 4f{sup 6}5d{sup 1}-4f{sup 7} from Eu{sup 2+} were observed at 417, 404 and 373 nm in air-annealed CaAl{sub 2}Si{sub 2}O{sub 8}, SrAl{sub 2}Si{sub 2}O{sub 8} and BaAl{sub 2}Si{sub 2}O{sub 8}, respectively, under ultraviolet excitation although the Eu{sup 3+} precursors were employed. In addition, under low-voltage electron beam excitation, Eu{sup 2+}-doped MAl{sub 2}Si{sub 2}O{sub 8} also shows strong blue or ultraviolet emission corresponding to 4f{sup 6}5d{sup 1}-4f{sup 7} transition. The reduction mechanism from Eu{sup 3+} to Eu{sup 2+} in these compounds has been discussed in detail. - Graphical abstract: It is of great importance to find that the reduction of Eu{sup 3+} to Eu{sup 2+} can be realized in a series of alkaline-earth metal aluminum silicates MAl{sub 2}Si{sub 2}O{sub 8} (M=Ca, Sr, Ba) just in air condition.

  20. A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 2: oncologic and infectious indications.

    PubMed

    Calzavara-Pinton, Pier Giacomo; Rossi, Maria Teresa; Sala, Raffaella

    2013-01-01

    Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) has been suggested as a useful treatment option in a number of skin tumors, other than approved indications, and infections. However, evidence is poor because it is mainly supported by isolated case reports or small case series, often with conflicting results. To assess the effectiveness, tolerability and safety of off-label MAL-PDT in daily clinical practice in 20 Italian hospitals, a retrospective observational study of medical records of patients treated for off-label oncologic and infectious skin conditions was carried out. In all patients standard treatment options had been either ineffective, unacceptably toxic, or medically contraindicated. Clinical data from 145 patients were analyzed. Actinic cheilitis showed a complete remission (CR) in 27 out of 43 treated patients and CR was maintained at follow-up. CR was registered in 3 of 8, 5 of 8 and 10 of 17 treated patients who were affected by extra-mammary Paget's disease (EMPD), erythroplasia of Queyrat (QD), and invasive squamous cell carcinoma (SCC), respectively. Five out of 19 patients with cutaneous T cell lymphoma had a complete remission. Cutaneous B-cell lymphoma, malignant fibrous histiocytoma, mastocytosis and nevus sebaceous were not responsive. Warts were treated in 30 patients and 15 had a complete remission. However, periungueal and plantar lesions were much more responsive than flat and common lesions. Condylomata showed a CR in 2 out of 5 male patients but treatment was painful. Bowenoid papulosis showed only a partial improvement. Atypical mycobacteriosis and chronic cutaneous leishmaniasis were successfully treated. Submammary candidal intertrigo and interdigital intertrigo with Pseudomonas aeruginosa did not improve. Among off-label oncological uses of MAL-PDT, the therapy of actinic cheilitis was the most investigated and showed the best results. In addition, MAL-PDT was used successfully in the majority of patients with QD, EMPD

  1. Preliminary technology report for Southern Sector bioremediation

    SciTech Connect

    Brigmon, R.L.; White, R.; Hazen, T.C.; Jones, D.; Berry, C.

    1997-06-01

    This project was designed to demonstrate the potential of intrinsic bioremediation and phytoremediation in the Southern Sector of the A/M-Area at the Savannah River Site. A subsurface plume of trichloroethylene (TCE) and perchloroethylene (PCE) is present in the Lost Lake aquifer upgradient of the study site and is predicted to impact the area at some point in the future. The surface area along the Lost lake aquifer seep line where the plume is estimated to emerge was identified. Ten sites along the seep line were selected for biological, chemical, and contaminant treatability analyses. A survey was undertaken in this area to to quantify the microbial and plant population known to be capable of remediating TCE and PCE. The current groundwater quality upgradient and downgradient of the zone of influence was determined. No TCE or PCE was found in the soils or surface water from the area tested at this time. A TCE biodegradation treatability test was done on soil from the 10 selected locations. From an initial exposure of 25 ppm of TCE, eight of the samples biodegraded up to 99.9 percent of all the compound within 6 weeks. This biodegradation of TCE appears to be combination of aerobic and anaerobic microbial activity as intermediates that were detected in the treatability test include vinyl chloride (VC) and the dichloroethenes (DCE) 1,2-cis-dichloroethylene and 1,1-dichloroethylene. The TCE biological treatability studies were combines with microbiological and chemical analyses. The soils were found through immunological analysis with direct fluorescent antibodies (DFA) and microbiological analysis with direct fluorescent antibodies (DFA) and microbiological analysis to have a microbial population of methanotrophic bacteria that utilize the enzyme methane monooxygenase (MMO) and cometabolize TCE.

  2. Alternate-Fueled Combustion-Sector Emissions

    NASA Technical Reports Server (NTRS)

    Saxena, Nikita T.; Thomas, Anna E.; Shouse, Dale T.; Neuroth, Craig; Hendricks, Robert C.; Lynch, Amy; Frayne, Charles W.; Stutrud, Jeffrey S.; Corporan, Edwin; Hankins, Terry

    2012-01-01

    In order to meet rapidly growing demand for fuel, as well as address environmental concerns, the aviation industry has been testing alternate fuels for performance and technical usability in commercial and military aircraft. Currently, alternate aviation fuels must satisfy MIL-DTL- 83133F(2008) (military) or ASTM D 7566- Annex(2011) (commercial) standards and are termed drop-in fuel replacements. Fuel blends of up to 50% alternative fuel blended with petroleum (JP-8), which have become a practical alternative, are individually certified on the market. In order to make alternate fuels (and blends) a viable option for aviation, the fuel must be able to perform at a similar or higher level than traditional petroleum fuel. They also attempt to curb harmful emissions, and therefore a truly effective alternate fuel would emit at or under the level of currently used fuel. This paper analyzes data from gaseous and particulate emissions of an aircraft combustor sector. The data were evaluated at various inlet conditions, including variation in pressure and temperature, fuel-to-air ratios, and percent composition of alternate fuel. Traditional JP-8+100 data were taken as a baseline, and blends of JP- 8+100 with synthetic-paraffinic-kerosene (SPK) fuel (Fischer-Tropsch (FT)) were used for comparison. Gaseous and particulate emissions, as well as flame luminosity, were assessed for differences between FT composition of 0%, 50%, and 100%. The data showed that SPK fuel (a FT-derived fuel) had slightly lower harmful gaseous emissions, and smoke number information corroborated the hypothesis that SPK-FT fuels are cleaner burning fuels.

  3. Sectoral Economies, Economic Contexts, and Attitudes toward Immigration

    PubMed Central

    Donnelly, Michael J.

    2013-01-01

    Do economic considerations shape attitudes toward immigration? In this article, we consider the relationship between economic interests and immigration preferences by examining how developments in individuals' sectors of employment affect these views. Using survey data across European countries from 2002 to 2009 and employing new measures of industry-level exposure to immigration, we find that sectoral economies shape opinions about immigration. Individuals employed in growing sectors are more likely to support immigration than are those employed in shrinking sectors. Moreover, the economic context matters: Making use of the exogenous shock to national economies represented by the 2008 financial crisis, we show that sector-level inflows of immigrant workers have little effect on preferences when economies are expanding, but that they dampen support for immigration when economic conditions deteriorate and confidence in the economy declines. These sectoral effects remain even when controlling for natives' views about the impact of immigration on the national economy and culture. When evaluating immigration policy, individuals thus appear to take into account whether their sector of employment benefits economically from immigration. PMID:24363457

  4. Cross-Sector Impact Analysis of Industrial Efficiency Measures

    SciTech Connect

    Morrow, William; CreskoEngineering, Joe; Carpenter, Alberta; Masanet, Eric; Nimbalkar, Sachin U; Shehabi, Arman

    2013-01-01

    The industrial or manufacturing sector is a foundational component to all economic activity. In addition to being a large direct consumer of energy, the manufacturing sector also produces materials, products, and technologies that influence the energy use of other economic sectors. For example, the manufacturing of a lighter-weight vehicle component affects the energy required to ship that component as well as the fuel efficiency of the assembled vehicle. Many energy efficiency opportunities exist to improve manufacturing energy consumption, however comparisons of manufacturing sector energy efficiency investment opportunities tend to exclude any impacts that occur once the product leaves the factory. Expanding the scope of analysis to include energy impacts across different stages of product life-cycle can highlight less obvious opportunities and inform actions that create the greatest economy-wide benefits. We present a methodology and associated analysis tool (LIGHTEnUP Lifecycle Industry GHgas, Technology and Energy through the Use Phase) that aims to capture both the manufacturing sector energy consumption and product life-cycle energy consumption implications of manufacturing innovation measures. The tool architecture incorporates U.S. national energy use data associated with manufacturing, building operations, and transportation. Inputs for technology assessment, both direct energy saving to the manufacturing sector, and indirect energy impacts to additional sectors are estimated through extensive literature review and engineering methods. The result is a transparent and uniform system of comparing manufacturing and use-phase impacts of technologies.

  5. Has the Swap Influenced Aid Flows in the Health Sector?

    PubMed

    Sweeney, Rohan; Mortimer, Duncan

    2016-05-01

    The sector wide approach (SWAp) emerged during the 1990s as a mechanism for managing aid from the multiplicity of development partners that operate in the recipient country's health, education or agricultural sectors. Health SWAps aim to give increased control to recipient governments, allowing greater domestic influence over how health aid is allocated and facilitating allocative efficiency gains. This paper assesses whether health SWAps have increased recipient control of health aid via increased general sector-support and have facilitated (re)allocations of health aid across disease areas. Using a uniquely compiled panel data set of countries receiving development assistance for health over the period 1990-2010, we employ fixed effects and dynamic panel models to assess the impact of introducing a health SWAp on levels of general sector-support for health and allocations of health-sector aid across key funding silos (including HIV, 'maternal and child health' and 'sector-support'). Our results suggest that health SWAps have influenced health-sector aid flows in a manner consistent with increased recipient control and improvements in allocative efficiency.

  6. Behavioral economics perspectives on public sector pension plans.

    PubMed

    Beshears, John; Choi, James J; Laibson, David; Madrian, Brigitte C

    2011-04-01

    We describe the pension plan features of the states and the largest cities and counties in the U.S. Unlike in the private sector, defined benefit (DB) pensions are still the norm in the public sector. However, a few jurisdictions have shifted toward defined contribution (DC) plans as their primary savings plan, and fiscal pressures are likely to generate more movement in this direction. Holding fixed a public employee's work and salary history, we show that DB retirement income replacement ratios vary greatly across jurisdictions. This creates large variation in workers' need to save for retirement in other accounts. There is also substantial heterogeneity across jurisdictions in the savings generated in primary DC plans because of differences in the level of mandatory employer and employee contributions. One notable difference between public and private sector DC plans is that public sector primary DC plans are characterized by required employee or employer contributions (or both), whereas private sector plans largely feature voluntary employee contributions that are supplemented by an employer match. We conclude by applying lessons from savings behavior in private sector savings plans to the design of public sector plans.

  7. How does retiree health insurance influence public sector employee saving?

    PubMed

    Clark, Robert L; Mitchell, Olivia S

    2014-12-01

    Economic theory predicts that employer-provided retiree health insurance (RHI) benefits have a crowd-out effect on household wealth accumulation, not dissimilar to the effects reported elsewhere for employer pensions, Social Security, and Medicare. Nevertheless, we are unaware of any similar research on the impacts of retiree health insurance per se. Accordingly, the present paper utilizes a unique data file on respondents to the Health and Retirement Study, to explore how employer-provided retiree health insurance may influence net household wealth among public sector employees, where retiree healthcare benefits are still quite prevalent. Key findings include the following: Most full-time public sector employees anticipate having employer-provided health insurance coverage in retirement, unlike most private sector workers.Public sector employees covered by RHI had substantially less wealth than similar private sector employees without RHI. In our data, Federal workers had about $82,000 (18%) less net wealth than private sector employees lacking RHI; state/local workers with RHI accumulated about $69,000 (or 15%) less net wealth than their uninsured private sector counterparts.After controlling on socioeconomic status and differences in pension coverage, net household wealth for Federal employees was $116,000 less than workers without RHI and the result is statistically significant; the state/local difference was not.

  8. Behavioral economics perspectives on public sector pension plans

    PubMed Central

    BESHEARS, JOHN; CHOI, JAMES J.; LAIBSON, DAVID; MADRIAN, BRIGITTE C.

    2011-01-01

    We describe the pension plan features of the states and the largest cities and counties in the U.S. Unlike in the private sector, defined benefit (DB) pensions are still the norm in the public sector. However, a few jurisdictions have shifted toward defined contribution (DC) plans as their primary savings plan, and fiscal pressures are likely to generate more movement in this direction. Holding fixed a public employee’s work and salary history, we show that DB retirement income replacement ratios vary greatly across jurisdictions. This creates large variation in workers’ need to save for retirement in other accounts. There is also substantial heterogeneity across jurisdictions in the savings generated in primary DC plans because of differences in the level of mandatory employer and employee contributions. One notable difference between public and private sector DC plans is that public sector primary DC plans are characterized by required employee or employer contributions (or both), whereas private sector plans largely feature voluntary employee contributions that are supplemented by an employer match. We conclude by applying lessons from savings behavior in private sector savings plans to the design of public sector plans. PMID:21789032

  9. Dark matter and dark forces from a supersymmetric hidden sector

    NASA Astrophysics Data System (ADS)

    Andreas, S.; Goodsell, M. D.; Ringwald, A.

    2013-01-01

    We show that supersymmetric “dark force” models with gravity mediation are viable. To this end, we analyze a simple string-inspired supersymmetric hidden sector model that interacts with the visible sector via kinetic mixing of a light Abelian gauge boson with the hypercharge. We include all induced interactions with the visible sector such as neutralino mass mixing and the Higgs portal term. We perform a detailed parameter space scan comparing the produced dark matter relic abundance and direct-detection cross sections to current experiments.

  10. Theory and Motivations of Dark Sector Dark Matter and Forces

    NASA Astrophysics Data System (ADS)

    Schuster, Philip

    2017-01-01

    We present the theory and motivations underlying ``dark'' or ``hidden'' sector dark matter and new force scenarios. Dark sector scenarios with sub-GeV mass scales have attracted particular attention in the past several years, motivated in part by findings from direct detection, satellite, and LHC experiments, as well as precision measurements. Moreover, these scenarios offer some of the simplest and least explored possibilities for dark matter. As such, sub-GeV dark sector scenarios have become the focus of a broad and growing international program of experiments.

  11. The worldwide market for photovoltaics in the rural sector

    NASA Technical Reports Server (NTRS)

    Brainard, W. A.

    1982-01-01

    Attention is given to the assessment of results obtained by three NASA studies aimed at determining the global market for stand-alone photovoltaic (PV) power systems in the village power, cottage industry, and agricultural applications areas of the rural sector. An attempt was made to identify technical, social, and institutional barriers to PV system implementation, as well as the funding sources available to potential users. Country- and sector-specific results are discussed, and marketing strategies appropriate for each sector are suggested for the benefit of American PV products manufacturers.

  12. Brownfields Shifting Gears: Driving Toward Auto Sector Property Revitalization

    EPA Pesticide Factsheets

    This is an overview of community success stories. By building strong partnerships and setting priorities for recovery and revitalization, the public and private sectors are realizing a great deal of success in addressing idle industrial brownfields.

  13. India's growing clinical research sector: opportunity for global companies.

    PubMed

    Varawalla, Nermeen

    2007-06-01

    Backed by a compelling foundation of essential requirements necessary for effective clinical trial conduct, and aided by initiatives that address concerns of data quality, regulatory timelines and IP protection, the clinical development sector in India has experienced annual revenue growth rates of 25% in the past two to three years, and is poised to participate substantially in global drug development. As both clinical trial sponsors and CROs increase their research capabilities in India, the clinical development sector is facing challenges with staff resourcing and facilities. Existing initiatives in the clinical sector must continue, and further investment must be made by stakeholders to overcome the current limitations in sector growth. Furthermore, global organizations seeking to derive long-term sustainable revenue growth and competitive advantage in the global marketplace from their business units in India must establish an appropriate organizational culture and an effective intra-organizational and industry interface for their operations.

  14. Voluntary agreements in the industrial sector in China

    SciTech Connect

    Price, Lynn; Worrell, Ernst; Sinton, Jonathan

    2003-03-31

    China faces a significant challenge in the years ahead to continue to provide essential materials and products for a rapidly-growing economy while addressing pressing environmental concerns. China's industrial sector is heavily dependent on the country's abundant, yet polluting, coal resources. While tremendous energy conservation and environmental protection achievements were realized in the industrial sector in the past, there remains a great gulf between the China's level of energy efficiency and that of the advanced countries of the world. Internationally, significant energy efficiency improvement in the industrial sector has been realized in a number of countries using an innovative policy mechanism called Voluntary Agreements. This paper describes international experience with Voluntary Agreements in the industrial sector as well as the development of a pilot program to test the use of such agreements with two steel mills in Shandong Province, China.

  15. Printing and Related Support Activities Sector (NAICS 323)

    EPA Pesticide Factsheets

    Find environmental regulatory and compliance information for the printing sector, including NESHAPs for paper surface coating, RCRA hazardous waste guide for small business, and a pollution prevention guidance for lithographic and screen printing

  16. Questions and Answers About Alternatives in Each Sector

    EPA Pesticide Factsheets

    The following list of questions and answers provides an overview of the regulations governing the use of substitutes that are reviewed under the Significant New Alternatives Policy (SNAP) program in various industrial sectors.

  17. American Indian and Alaska Native Tribal Governments Sectors (NAICS 921150)

    EPA Pesticide Factsheets

    Find environmental regulatory information for Tribal Governments Sectors. Learn about American Indian Tribal laws and regulations, tribal drinking water programs, as well as greenhouse gas programs and NESHAPs for boilers and landfills

  18. Promoting a Veteran Workforce for the Water Sector

    EPA Pesticide Factsheets

    EPA signed a memorandum of understanding with the Department of Veterans Affairs to work jointly on promotional activities to help connect veterans with disabilities with career opportunities in the water sector.

  19. Mining (except Oil and Gas) Sector (NAICS 212)

    EPA Pesticide Factsheets

    EPA Regulatory and enforcement information for the mining sector, including metal mining & nonmetallic mineral mining and quarrying. Includes information about asbestos, coal mining, mountaintop mining, Clean Water Act section 404, and abandoned mine lands

  20. Elements affecting food waste in the food service sector.

    PubMed

    Heikkilä, Lotta; Reinikainen, Anu; Katajajuuri, Juha-Matti; Silvennoinen, Kirsi; Hartikainen, Hanna

    2016-10-01

    Avoidable food waste is produced in the food service sector, with significant ecological and economical impacts. In order to understand and explain better the complex issue of food waste a qualitative study was conducted on the reasons for its generation in restaurants and catering businesses. Research data were collected during three participatory workshops for personnel from three different catering sector companies in Finland. Based on synthesized qualitative content analysis, eight elements influencing production and reduction of food waste were identified. Results revealed the diversity of managing food waste in the food service sector and how a holistic approach is required to prevent and reduce it. It is crucial to understand that food waste is manageable and should be an integral component of the management system. The model of eight factors provides a framework for recognition and management of food waste in the food service sector.

  1. Fluorescence and phosphorescence properties of the low temperature forms of the MAl{sub 2}Si{sub 2}O{sub 8}:Eu{sup 2+} (M=Ca, Sr, Ba) compounds

    SciTech Connect

    Clabau, Frederic; Garcia, Alain; Bonville, Pierre; Gonbeau, Danielle; Le Mercier, Thierry; Deniard, Philippe; Jobic, Stephane

    2008-06-15

    The fluorescence and phosphorescence properties of Europium-doped MAl{sub 2}Si{sub 2}O{sub 8} (M=Ca, Sr, Ba) are reinvestigated and discussed on the basis of the propensity of an activator to agglomerate with an oxygen vacancy. Due to a stronger attraction of the anion vacancy towards Eu{sup 2+} cations going from BaAl{sub 2}Si{sub 2}O{sub 8} to SrAl{sub 2}Si{sub 2}O{sub 8} and CaAl{sub 2}Si{sub 2}O{sub 8} host lattices, the interpretation of the fluorescence spectra turns out to be less trivial in the Ca and Sr host lattices than in the Ba one and requests the account for Eu{sup 2+} cations lying at alkaline-earth sites with or without vacancy in their neighborhood. Phosphorescence in these compounds is highlighted. - Graphical abstract: The Eu{sup 2+}-doped MAl{sub 2}Si{sub 2}O{sub 8} (M=Ca, Sr, and Ba) aluminosilicates exhibit a bluish white luminescence, which can last several minutes after the removal of the excitation. The account for Eu{sup 2+} cations coupled with defects is required to explain fluorescence spectra.

  2. ERP System Implementation: An Oil and Gas Exploration Sector Perspective

    NASA Astrophysics Data System (ADS)

    Mishra, Alok; Mishra, Deepti

    Enterprise Resource Planning (ERP) systems provide integration and optimization of various business processes which leads to improved planning and decision quality, smoother coordination between business units resulting in higher efficiency, and quicker response time to customer demands and inquiries. This paper reports challenges, opportunities and outcome of ERP implementation in Oil & Gas exploration sector. This study will facilitate in understanding transition, constraints and implementation of ERP in this sector and also provide guidelines from lessons learned in this regard.

  3. Energy finance data warehouse: Tracking revenues through the power sector

    DOE PAGES

    Claire, Zeng; Hendrickson, Stephen; Lee, Sangkeun; ...

    2017-03-24

    Reliable data is needed to understand financial relationships in the power sector. However, relevant data acquisition and visualization can be a challenge due to the fragmented nature of the power sector. The Energy Policy and Systems Analysis office of the U.S. Department of Energy led a team of data scientists at Oak Ridge National Lab to collect revenue information from a variety of sources.

  4. Development of Greenhouse Gas Mitigation Options for Alberta's Energy Sector

    NASA Astrophysics Data System (ADS)

    Subramanyam, Veena

    Alberta is the third largest economy in Canada and is expected to grow significantly in the coming decade. The energy sector plays a major role in Alberta's economy. The objective of this research is to develop various greenhouse gas (GHG) mitigations scenarios in the energy demand and supply sectors for the Province of Alberta. This is done through an energy-environment planning and forecasting tool called Long Range Energy Alternative Planning system model (LEAP). By using LEAP, a sankey diagram for energy and emission flows for the Province of Alberta has been developed. A reference case also called as business-as-usual scenario was developed for a study period of 25 years (2005-2030). The GHG mitigation scenarios encompassed various demand and supply side scenarios. In the energy conversion sector, mitigation scenarios for renewable power generation and inclusion of supercritical, ultra-supercritical and integrated gasification combined cycle (IGCC) plants were investigated. In the oil and gas sector, GHG mitigation scenarios with carbon capture and sequestration (CCS) option were considered. In Alberta's residential and commercial sector 4-6 MT of CO2 equivalents per year of GHG mitigation could be achieved with efficiency improvement. In the industrial sector up to 40 MT of CO2 equivalents per year of GHG reduction could be achieved with efficiency improvement. In the energy conversion sector large GHG mitigation potential lies in the oil and gas sector and also in power plants with carbon capture and storage (CCS) option. The total GHG mitigation possible in the supply side option is between 20--70 MT CO2 equivalents per year.

  5. Interplanetary magnetic sector polarity inferred from polar geomagnetic field observations

    NASA Technical Reports Server (NTRS)

    Friis-Christensen, E.; Lassen, K.; Wilcox, J. M.; Gonzalez, W.; Colburn, D. S.

    1971-01-01

    In order to infer the interplanetary sector polarity from polar geomagnetic field diurnal variations, measurements were carried out at Godhavn and Thule (Denmark) Geomagnetic Observatories. The inferred interplanetary sector polarity was compared with the polarity observed at the same time by Explorer 33 and 35 magnetometers. It is shown that the polarity (toward or away from the sun) of the interplanetary magnetic field can be reliably inferred from observations of the polar cap geomagnetic fields.

  6. SSL Demonstration: Area Lighting, Yuma Sector Border Patrol Area, AZ

    SciTech Connect

    2015-05-28

    Along the Yuma Sector Border Patrol Area in Yuma, Arizona, the GATEWAY program conducted a trial demonstration in which the incumbent quartz metal halide area lighting was replaced with LED at three pole locations at the Yuma Sector Border Patrol Area in Yuma, Arizona. The retrofit was documented to better understand LED technology performance in high-temperature environments. This document is a summary brief of the Phase 1.0 and 1.1 reports previously published on this demonstration.

  7. A Comparison of Cross-Sector Cyber Security Standards

    SciTech Connect

    Robert P. Evans

    2005-09-01

    This report presents a review and comparison (commonality and differences) of three cross-sector cyber security standards and an internationally recognized information technology standard. The comparison identifies the security areas covered by each standard and reveals where the standards differ in emphasis. By identifying differences in the standards, the user can evaluate which standard best meets their needs. For this report, only cross-sector standards were reviewed.

  8. University-Private Sector Research Partnerships in the Innovation Ecosystem

    DTIC Science & Technology

    2008-11-01

    researches with the flexibility to engage in sabbaticals and career transitions between academia, government, and the private sector. The Federal government...to support these career paths among their faculty. These practices can also be integrated into the structure of Federally funded university research... careers in this sector. However, it is difficult to imagine how this workforce expansion and overall increase in research capacity can be maintained by

  9. The pharmaceutical sector inquiry: 'Hamlet' in a nutshell.

    PubMed

    den Exter, André

    2010-03-01

    In July 2009, the European Commission (DG Competition) published a Communication on the pharmaceutical sector. This inquiry was launched because there were some indications that competition in the pharmaceutical market in the European Union might not be working well. The report examines the reasons for the observed delay. This article analyses the outcomes from a critical standpoint, arguing in favour of enhanced 'soft law' accountability mechanisms in the pharmaceutical sector, defending conditional patenting and the introduction of a Community patent.

  10. Computer program for flat sector thrust bearing performance

    NASA Technical Reports Server (NTRS)

    Presler, A. F.; Etsion, I.

    1977-01-01

    A versatile computer program is presented which achieves a rapid, numerical solution of the Reynolds equation for a flat sector thrust pad bearing with either compressible or liquid lubricants. Program input includes a range in values of the geometric and operating parameters of the sector bearing. Performance characteristics are obtained from the calculated bearing pressure distribution. These are the load capacity, center of pressure coordinates, frictional energy dissipation, and flow rates of liquid lubricant across the bearing edges. Two sample problems are described.

  11. E-Learning Readiness in the Academic Sector of Thailand

    ERIC Educational Resources Information Center

    Laohajaratsang, Thanomporn

    2009-01-01

    As e-learning in the academic sector serves as a crucial driving force in the development of e-learning in Thailand, this article looks at e-learning readiness in Thailand with a focus on the academic sector. The article is divided into four parts: (1) a brief history of e-learning in Thailand; (2) the infrastructure related to e-learning…

  12. Security Sector Reform’s Utility in Conflict Prevention

    DTIC Science & Technology

    2013-12-10

    NUMBER Security Sector’s Reforms ’ Utility in Conflict Prevention 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...force assistance and foreign internal defense are only two components of security sector reform ; thus, the promise that they will prevent conflict is...dubious at best. This study examines the various approaches to security sector reform and then applies the U.S. government’s methodology to security

  13. Distributed Generation System Characteristics and Costs in the Buildings Sector

    EIA Publications

    2013-01-01

    The Energy Information Administration (EIA) works with technology experts to project the cost and performance of future residential and commercial sector photovoltaic (PV) and small wind installations rather than developing technology projections in-house. These reports have always been available by request. By providing the reports online, EIA is increasing transparency for the assumptions used for our Annual Energy Outlook buildings sector distributed generation projections.

  14. United States Industrial Sector Energy End Use Analysis

    SciTech Connect

    Shehabi, Arman; Morrow, William R.; Masanet, Eric

    2012-05-11

    The United States Department of Energy’s (DOE) Energy Information Administration (EIA) conducts the Manufacturing Energy Consumption Survey (MECS) to provide detailed data on energy consumption in the manufacturing sector. The survey is a sample of approximately 15,000 manufacturing establishments selected from the Economic Census - Manufacturing Sector. MECS provides statistics on the consumption of energy by end uses (e.g., boilers, process, electric drives, etc.) disaggregated by North American Industry Classification System (NAICS) categories. The manufacturing sector (NAICS Sector 31-33) consists of all manufacturing establishments in the 50 States and the District of Columbia. According to the NAICS, the manufacturing sector comprises establishments engaged in the mechanical, physical, or chemical transformation of materials, substances, or components into new products. The establishments are physical facilities such as plants, factories, or mills. For many of the sectors in the MECS datasets, information is missing because the reported energy use is less than 0.5 units or BTUs, or is withheld to avoid disclosing data for individual establishments, or is withheld because the standard error is greater than 50%. We infer what the missing information likely are using several approximations techniques. First, much of the missing data can be easily calculated by adding or subtracting other values reported by MECS. If this is not possible (e.g. two data are missing), we look at historic MECS reports to help identify the breakdown of energy use in the past and assume it remained the same for the current MECS. Lastly, if historic data is also missing, we assume that 3 digit NAICS classifications predict energy use in their 4, 5, or 6 digit NAICS sub-classifications, or vice versa. Along with addressing data gaps, end use energy is disaggregated beyond the specified MECS allocations using additional industry specific energy consumption data. The result is a

  15. Energy Sector Adaptation in Response to Water Scarcity

    NASA Astrophysics Data System (ADS)

    Johnson, N. A.; Fricko, O.; Parkinson, S.; Riahi, K.

    2015-12-01

    Global energy systems models have largely ignored the impacts of water scarcity on the energy sector and the related implications for climate change mitigation. However, significant water is required in the production of energy, including for thermoelectric power plant cooling, hydropower generation, irrigation for bioenergy, and the extraction and refining of liquid fuels. With a changing climate and expectations of increasing competition for water from the agricultural and municipal sectors, it is unclear whether sufficient water will be available where needed to support water-intensive energy technologies in the future. Thus, it is important that water use and water constraints are incorporated into energy systems models to better understand energy sector adaptation to water scarcity. The global energy systems model, MESSAGE, has recently been updated to quantify the water consumption and withdrawal requirements of the energy sector and now includes several cooling technologies for addressing water scarcity. This study introduces water constraints into the model to examine whether and how the energy sector can adapt to water scarcity over the next century. In addition, the implications for climate mitigation are evaluated under a scenario in which warming is limited to 2˚C over the pre-industrial level. Given the difficulty of introducing meaningful water constraints into global models, we use a simplistic approach and evaluate a series of scenarios in which the water available to the energy sector is systematically reduced. This approach allows for the evaluation of energy sector adaptations under various levels of water scarcity and can provide insight into how water scarcity, whether from climate change or competing demands, may impact the energy sector in different world regions. This study will provide insight into the following questions: How does the energy sector adapt to water scarcity in different regions? What are the costs associated with adaptation

  16. Genesis of the Assif El Mal Zn-Pb (Cu, Ag) vein deposit. An extension-related Mesozoic vein system in the High Atlas of Morocco. Structural, mineralogical, and geochemical evidence

    USGS Publications Warehouse

    Bouabdellah, M.; Beaudoin, G.; Leach, D.L.; Grandia, F.; Cardellach, E.

    2009-01-01

    The Assif El Mal Zn-Pb (Cu-Ag) vein system, located in the northern flank of the High Atlas of Marrakech (Morocco), is hosted in a Cambro-Ordovician volcaniclastic and metasedimentary sequence composed of graywacke, siltstone, pelite, and shale interlayered with minor tuff and mudstone. Intrusion of synorogenic to postorogenic Late Hercynian peraluminous granitoids has contact metamorphosed the host rocks giving rise to a metamorphic assemblage of quartz, plagioclase, biotite, muscovite, chlorite, amphibole, chloritoid, and garnet. The Assif El Mal Zn-Pb (Cu-Ag) mineralization forms subvertical veins with ribbon, fault breccia, cockade, comb, and crack and seal textures. Two-phase liquid-vapor fluid inclusions that were trapped during several stages occur in quartz and sphalerite. Primary inclusion fluids exhibit Th mean values ranging from 104??C to 198??C. Final ice-melting temperatures range from -8.1??C to -12.8??C, corresponding to salinities of ???15 wt.% NaCl equiv. Halogen data suggest that the salinity of the ore fluids was largely due to evaporation of seawater. Late secondary fluid inclusions have either Ca-rich, saline (26 wt.% NaCl equiv.), or very dilute (3.5 wt.% NaCl equiv.) compositions and homogenization temperatures ranging from 75??C to 150??C. The ??18O and ??D fluid values suggest an isotopically heterogeneous fluid source involving mixing between connate seawater and black-shale-derived organic waters. Low ??13CVPDB values ranging from -7.5??? to -7.7??? indicate a homogeneous carbon source, possibly organic matter disseminated in black shale hosting the Zn-Pb (Cu-Ag) veins. The calculated ??34SH2S values for reduced sulfur (22.5??? to 24.3???) are most likely from reduction of SO42- in trapped seawater sulfate or evaporite in the host rocks. Reduction of sulfate probably occurred through thermochemical sulfate reduction in which organic matter was oxidized to produce CO2 which ultimately led to precipitation of saddle dolomite with

  17. Genesis of the Assif El Mal Zn-Pb (Cu, Ag) vein deposit. An extension-related Mesozoic vein system in the High Atlas of Morocco. Structural, mineralogical, and geochemical evidence

    NASA Astrophysics Data System (ADS)

    Bouabdellah, Mohammed; Beaudoin, Georges; Leach, David L.; Grandia, Fidel; Cardellach, Esteve

    2009-08-01

    The Assif El Mal Zn-Pb (Cu-Ag) vein system, located in the northern flank of the High Atlas of Marrakech (Morocco), is hosted in a Cambro-Ordovician volcaniclastic and metasedimentary sequence composed of graywacke, siltstone, pelite, and shale interlayered with minor tuff and mudstone. Intrusion of synorogenic to postorogenic Late Hercynian peraluminous granitoids has contact metamorphosed the host rocks giving rise to a metamorphic assemblage of quartz, plagioclase, biotite, muscovite, chlorite, amphibole, chloritoid, and garnet. The Assif El Mal Zn-Pb (Cu-Ag) mineralization forms subvertical veins with ribbon, fault breccia, cockade, comb, and crack and seal textures. Two-phase liquid-vapor fluid inclusions that were trapped during several stages occur in quartz and sphalerite. Primary inclusion fluids exhibit T h mean values ranging from 104°C to 198°C. Final ice-melting temperatures range from -8.1°C to -12.8°C, corresponding to salinities of ˜15 wt.% NaCl equiv. Halogen data suggest that the salinity of the ore fluids was largely due to evaporation of seawater. Late secondary fluid inclusions have either Ca-rich, saline (26 wt.% NaCl equiv.), or very dilute (3.5 wt.% NaCl equiv.) compositions and homogenization temperatures ranging from 75°C to 150°C. The δ18O and δD fluid values suggest an isotopically heterogeneous fluid source involving mixing between connate seawater and black-shale-derived organic waters. Low δ13CVPDB values ranging from -7.5‰ to -7.7‰ indicate a homogeneous carbon source, possibly organic matter disseminated in black shale hosting the Zn-Pb (Cu-Ag) veins. The calculated δ34SH2S values for reduced sulfur (22.5‰ to 24.3‰) are most likely from reduction of SO4 2- in trapped seawater sulfate or evaporite in the host rocks. Reduction of sulfate probably occurred through thermochemical sulfate reduction in which organic matter was oxidized to produce CO2 which ultimately led to precipitation of saddle dolomite with

  18. Thermal dark matter from a highly decoupled sector

    SciTech Connect

    Berlin, Asher; Hooper, Dan; Krnjaic, Gordan

    2016-11-17

    It has recently been shown that if the dark matter is in thermal equilibrium with a sector that is highly decoupled from the Standard Model, it can freeze out with an acceptable relic abundance, even if the dark matter is as heavy as ~1–100 PeV. In such scenarios, both the dark and visible sectors are populated after inflation, but with independent temperatures. The lightest particle in the dark sector will be generically long-lived and can come to dominate the energy density of the Universe. Upon decaying, these particles can significantly reheat the visible sector, diluting the abundance of dark matter and thus allowing for dark matter particles that are much heavier than conventional WIMPs. In this study, we present a systematic and pedagogical treatment of the cosmological history in this class of models, emphasizing the simplest scenarios in which a dark matter candidate annihilates into hidden sector particles which then decay into visible matter through the vector, Higgs, or lepton portals. In each case, we find ample parameter space in which very heavy dark matter particles can provide an acceptable thermal relic abundance. We also discuss possible extensions of models featuring these dynamics.

  19. Thermal dark matter from a highly decoupled sector

    DOE PAGES

    Berlin, Asher; Hooper, Dan; Krnjaic, Gordan

    2016-11-17

    It has recently been shown that if the dark matter is in thermal equilibrium with a sector that is highly decoupled from the Standard Model, it can freeze out with an acceptable relic abundance, even if the dark matter is as heavy as ~1–100 PeV. In such scenarios, both the dark and visible sectors are populated after inflation, but with independent temperatures. The lightest particle in the dark sector will be generically long-lived and can come to dominate the energy density of the Universe. Upon decaying, these particles can significantly reheat the visible sector, diluting the abundance of dark mattermore » and thus allowing for dark matter particles that are much heavier than conventional WIMPs. In this study, we present a systematic and pedagogical treatment of the cosmological history in this class of models, emphasizing the simplest scenarios in which a dark matter candidate annihilates into hidden sector particles which then decay into visible matter through the vector, Higgs, or lepton portals. In each case, we find ample parameter space in which very heavy dark matter particles can provide an acceptable thermal relic abundance. We also discuss possible extensions of models featuring these dynamics.« less

  20. Sector mapping method for 3D detached retina visualization.

    PubMed

    Zhai, Yi-Ran; Zhao, Yong; Zhong, Jie; Li, Ke; Lu, Cui-Xin; Zhang, Bing

    2016-10-01

    A new sphere-mapping algorithm called sector mapping is introduced to map sector images to the sphere of an eyeball. The proposed sector-mapping algorithm is evaluated and compared with the plane-mapping algorithm adopted in previous work. A simulation that maps an image of concentric circles to the sphere of the eyeball and an analysis of the difference in distance between neighboring points in a plane and sector were used to compare the two mapping algorithms. A three-dimensional model of a whole retina with clear retinal detachment was generated using the Visualization Toolkit software. A comparison of the mapping results shows that the central part of the retina near the optic disc is stretched and its edges are compressed when the plane-mapping algorithm is used. A better mapping result is obtained by the sector-mapping algorithm than by the plane-mapping algorithm in both the simulation results and real clinical retinal detachment three-dimensional reconstruction.

  1. Commissioning the cryogenic system of the first LHC sector

    SciTech Connect

    Millet, F.; Claudet, S.; Ferlin, G.; Perin, A.; Riddone, G.; Serio, L.; Soubiran, M.; Tavian, L.; Ronayette, L.; Rabehl, R.; /Fermilab

    2007-12-01

    The LHC machine, composed of eight sectors with superconducting magnets and accelerating cavities, requires a complex cryogenic system providing high cooling capacities (18 kW equivalent at 4.5 K and 2.4 W at 1.8 K per sector produced in large cold boxes and distributed via 3.3-km cryogenic transfer lines). After individual reception tests of the cryogenic subsystems (cryogen storages, refrigerators, cryogenic transfer lines and distribution boxes) performed since 2000, the commissioning of the cryogenic system of the first LHC sector has been under way since November 2006. After a brief introduction to the LHC cryogenic system and its specificities, the commissioning is reported detailing the preparation phase (pressure and leak tests, circuit conditioning and flushing), the cool-down sequences including the handling of cryogenic fluids, the magnet powering phase and finally the warm-up. Preliminary conclusions on the commissioning of the first LHC sector will be drawn with the review of the critical points already solved or still pending. The last part of the paper reports on the first operational experience of the LHC cryogenic system in the perspective of the commissioning of the remaining LHC sectors and the beam injection test.

  2. Mitigation technologies and measures in energy sector of Kazakstan

    SciTech Connect

    Pilifosova, O.; Danchuk, D.; Temertekov, T.

    1996-12-31

    An important commitment in the UN Framework Convention on Climate Change is to conduct mitigation analysis and to communicate climate change measures and policies. In major part reducing CO{sub 2} as well as the other greenhouse gas emissions in Kazakstan, can be a side-product of measures addressed to increasing energy efficiency. Since such measures are very important for the national economy, mitigation strategies in the energy sector of Kazakstan are directly connected with the general national strategy of the energy sector development. This paper outlines the main measures and technologies in energy sector of Kazakstan which can lead to GHG emissions reduction and presents the results of current mitigation assessment. The mitigation analysis is addressed to energy production sector. A baseline and six mitigation scenarios were developed to evaluate the most attractive mitigation options, focusing on specific technologies which have been already included in sustainable energy programs. According to the baseline projection, Kazakstan`s CO{sub 2} emissions will not exceed their 1990 level until 2005. The potential for CO{sub 2} emission reduction is estimated to be about 11 % of the base line emission level by the end of considered period (in 2020). The main mitigation options in the energy production sector in terms of mitigation potential and technical and economical feasibility include rehabilitation of thermal power plants aimed to increasing efficiency, use of nuclear energy and further expansion in the use of hydro energy based on small hydroelectric power plants.

  3. Assessing global resource utilization efficiency in the industrial sector.

    PubMed

    Rosen, Marc A

    2013-09-01

    Designing efficient energy systems, which also meet economic, environmental and other objectives and constraints, is a significant challenge. In a world with finite natural resources and large energy demands, it is important to understand not just actual efficiencies, but also limits to efficiency, as the latter identify margins for efficiency improvement. Energy analysis alone is inadequate, e.g., it yields energy efficiencies that do not provide limits to efficiency. To obtain meaningful and useful efficiencies for energy systems, and to clarify losses, exergy analysis is a beneficial and useful tool. Here, the global industrial sector and industries within it are assessed by using energy and exergy methods. The objective is to improve the understanding of the efficiency of global resource use in the industrial sector and, with this information, to facilitate the development, prioritization and ultimate implementation of rational improvement options. Global energy and exergy flow diagrams for the industrial sector are developed and overall efficiencies for the global industrial sector evaluated as 51% based on energy and 30% based on exergy. Consequently, exergy analysis indicates a less efficient picture of energy use in the global industrial sector than does energy analysis. A larger margin for improvement exists from an exergy perspective, compared to the overly optimistic margin indicated by energy.

  4. Thermal dark matter from a highly decoupled sector

    NASA Astrophysics Data System (ADS)

    Berlin, Asher; Hooper, Dan; Krnjaic, Gordan

    2016-11-01

    It has recently been shown that if the dark matter is in thermal equilibrium with a sector that is highly decoupled from the Standard Model, it can freeze out with an acceptable relic abundance, even if the dark matter is as heavy as ˜1 - 100 PeV . In such scenarios, both the dark and visible sectors are populated after inflation, but with independent temperatures. The lightest particle in the dark sector will be generically long-lived and can come to dominate the energy density of the Universe. Upon decaying, these particles can significantly reheat the visible sector, diluting the abundance of dark matter and thus allowing for dark matter particles that are much heavier than conventional WIMPs. In this paper, we present a systematic and pedagogical treatment of the cosmological history in this class of models, emphasizing the simplest scenarios in which a dark matter candidate annihilates into hidden sector particles which then decay into visible matter through the vector, Higgs, or lepton portals. In each case, we find ample parameter space in which very heavy dark matter particles can provide an acceptable thermal relic abundance. We also discuss possible extensions of models featuring these dynamics.

  5. Trends in Private Sector Development in World Bank Education Projects. Policy Research Working Paper Series.

    ERIC Educational Resources Information Center

    Sosale, Shobhana

    The private sector is playing an increasingly important role in financing and providing educational services in many countries. (Often the term "private sector" encompasses households' out-of-pocket expenses rather than describing for-profit or not-for-profit sectors.) Private sector development has not arisen primarily through public…

  6. General and Partial Equilibrium Modeling of Sectoral Policies to Address Climate Change in the United States

    SciTech Connect

    Pizer, William; Burtraw, Dallas; Harrington, Winston; Newell, Richard; Sanchirico, James; Toman, Michael

    2003-03-31

    This document provides technical documentation for work using detailed sectoral models to calibrate a general equilibrium analysis of market and non-market sectoral policies to address climate change. Results of this work can be found in the companion paper, "Modeling Costs of Economy-wide versus Sectoral Climate Policies Using Combined Aggregate-Sectoral Model".

  7. The worldwide market for photovoltaics in the rural sector

    NASA Astrophysics Data System (ADS)

    Brainard, W. A.

    1982-09-01

    The worldwide market for stand-alone photovoltaic power systems in three specific segments of the rural sector were determined. The worldwide market for photovoltaic power systems for village power, cottage industry, and agricultural applications were addressed. The objectives of these studies were to: The market potential for small stand-alone photovoltaic power system in specific application areas was assessed. Technical, social and institutional barriers to PV utilization were identified. Funding sources available to potential users was also identified and marketing strategies appropriate for each sector were recommended to PV product manufacturers. The studies were prepared on the basis of data gathered from domestic sources and from field trips to representative countries. Both country-specific and sector-specific results are discussed, and broadly applicable barriers pertinent to international marketing of PV products are presented.

  8. The role of criminal law within the healthcare sector.

    PubMed

    Alhafaji, Yasmin

    2012-12-01

    Health is for most of us the most precious thing one can have. However, in practice situations occur where the patient is harmed within the healthcare institution. Traditionally, there are several ways to protect individuals in society: with civil, criminal and administrative procedures. Over the years in the Netherlands complaints procedures were established in which the complaints about healthcare providers' performance can be handled. Recently, there are some developments within the criminal law that concern the healthcare sector. Examples are: the establishment of the Public Prosecution Service's Expertise Center on Medical Matters, appointments of medical prosecutors. In addition, in legal literature suggestions are made that criminal law is nowadays applied in order to provide redress to the patients (relatives) and as a 'safety tool' that is to ensure security and to counter the risks within the healthcare sector. The article discusses the role of criminal law within the healthcare sector, and in particular, whether criminal procedure is suitable for handling complaints about healthcare.

  9. The worldwide market for photovoltaics in the rural sector

    NASA Technical Reports Server (NTRS)

    Brainard, W. A.

    1982-01-01

    The worldwide market for stand-alone photovoltaic power systems in three specific segments of the rural sector were determined. The worldwide market for photovoltaic power systems for village power, cottage industry, and agricultural applications were addressed. The objectives of these studies were to: The market potential for small stand-alone photovoltaic power system in specific application areas was assessed. Technical, social and institutional barriers to PV utilization were identified. Funding sources available to potential users was also identified and marketing strategies appropriate for each sector were recommended to PV product manufacturers. The studies were prepared on the basis of data gathered from domestic sources and from field trips to representative countries. Both country-specific and sector-specific results are discussed, and broadly applicable barriers pertinent to international marketing of PV products are presented.

  10. Prototype sector production for the STAR inner TPC upgrade

    NASA Astrophysics Data System (ADS)

    Yang, Chi; STAR Collaboration

    2017-01-01

    The STAR experiment at the Relativistic Heavy Ion Collider (RHIC) is upgrading the Inner TPC sectors (iTPC). By increasing the number of inner pad rows from 13 to 40 and renewing the inner sector wires, this major detector upgrade will improve the rapidity coverage from |η| < 1 to |η| < 1.5, provide better momentum resolution, and better energy loss (dE/dx) resolution. The iTPC upgrade is crucial to STAR Beam Energy Scan Phase II (BES- II) program, which will provide in-depth understanding on QCD phase diagram and in-medium modification. In this paper we report on progress on the iTPC sector construction. The iTPC module fabrication techniques and testing results from the first full size prototype are presented.

  11. Agricultural sector impacts of making ethanol from grain

    SciTech Connect

    Hertzmark, D.; Ray, D.; Parvin, G.

    1980-03-01

    This report presents the results of a model of the effects on the agricultural sector of producing ethanol from corn in the United States between 1979 and 1983. The model is aggregated at the national level, and results are given for all of the major food and feed crops, ethanol joint products, farm income, government payment, and agricultural exports. A stochastic simulation was performed to ascertain the impacts of yield and demand variations on aggregate performance figures. Results indicate minimal impacts on the agricultural sector for production levels of less than 1 billion gallons of ethanol per year. For higher production levels, corn prices will rise sharply, the agricultural sector will be more vulnerable to variations in yields and demands, and joint-product values will fall. Possibilities for ameliorating such effects are discussed, and such concepts as net energy and the biomass refinery are explored.

  12. Real & Financial Sectors, ``koq Financenaann..'' & Elbio Dagotto's Interactions

    NASA Astrophysics Data System (ADS)

    Maksoed, Wh-

    2016-10-01

    In conjunctions between PMRI/Pendidikan Matematika Realistik Indonesia fom Dr. RK Sembiring to ``ASTRANOMICS'': the New Reality in Business Aviation herewith provided `interaction between real & financial sector' and financialisation from Heinrich Bortis: ``the Real & Financial Sector of a Monetary Production Economy in the perspective of classical-Keynesian political economy'' ever specifies ``sector Riil'' from HE. Mr. Ir. Aburizal Bakrie. Instead describes the context of CMR/Colossal Magnetoresistance cq Carlos SLIM, the richest entrepreneur in the world 2014 also obtaines Dagotto & Tokura: ``Strongly correlated Electronic Materials: Present & Future'',MRS Bulletin, Nov, 2008. Ever existed of UN Secretary General Kofie Atta Annan, for Lih-AT TA-ruh di mana?'' are ```koq Financenaann..?'' in-between conjunctions. CMR are other notions of GiantMagnetoresistance from Fert & Grundberg who awarded with Nobel Prize in Physics, 2007. Heartfelt Gratitudes to HE. Mr. Prof. Ir. HANDOJO.

  13. Laparoscopic management of post-cholecystectomy sectoral artery pseudoaneurysm

    PubMed Central

    Panda, Nilanjan; Narasimhan, Mohan; Gunaraj, Alwin; Ardhanari, Ramesh

    2014-01-01

    Vascular injuries during laparoscopic cholecystectomy can occur similar to biliary injuries and mostly represented by intraoperative bleeding. Hepatic artery system pseudoaneurysm are rare. It occurs in the early or late postoperative course. Patients present with pallor, signs of haemobillia and altered liver function. We report a case of right posterior sectoral artery pseudoaneurysm detected 2 weeks after laparoscopic cholecystectomy and successfully repaired laparoscopically. We also describe how laparoscopic pringle clamping saved the conversion. The actively bleeding right posterior sectoral artery pseudoaneurysm was diagnosed by CT angiogram. Embolisation, usually the treatment of choice, would have risked liver insufficiency as hepatic artery proper was at risk because the origin the bleeding artery was just after its bifurcation. Isolated right hepatic artery embolisation can also cause hepatic insufficiency. To our knowledge this is the first reported case of laparoscopic repair of post-laparoscopic cholecystectomy bleeding sectoral artery pseudoaneurysm. PMID:24501508

  14. A fair day's wage? Perceptions of public sector pay.

    PubMed

    Furnham, Adrian; Stieger, Stefan; Haubner, Tanja; Voracek, Martin; Swami, Viren

    2009-12-01

    There is a scarcity of evidence pertaining to the general public's perception of public sector pay. Hence, in the present study, 161 women and 149 men were asked to estimate the wages 35 public sector professions should receive annually in the fictitious nation of Maldoria, based on a comparison value of an annual income of T10,000 for general practitioners. Analysis showed that only pilots were given a higher annual income than general practitioners; miners and local government workers were also provided with relatively high annual incomes. By contrast, newscasters were provided with the lowest annual income. Participants' sex did not affect these evaluations, and other demographic variables and public sector-related information of the participants were poor predictors of their evaluations. The implications of this research on public attitudes toward wage determination are discussed, and avenues for further research highlighted.

  15. Dark matter antibaryons from a supersymmetric hidden sector

    NASA Astrophysics Data System (ADS)

    Blinov, Nikita; Morrissey, David E.; Sigurdson, Kris; Tulin, Sean

    2012-11-01

    The cosmological origin of both dark and baryonic matter can be explained through a unified mechanism called hylogenesis where baryon and antibaryon numbers are divided between the visible sector and a GeV-scale hidden sector, while the Universe remains net baryon symmetric. The “missing” antibaryons, in the form of exotic hidden states, are the dark matter. We study model-building, cosmological, and phenomenological aspects of this scenario within the framework of supersymmetry, which naturally stabilizes the light hidden sector and electroweak mass scales. Inelastic dark matter scattering on visible matter destroys nucleons, and nucleon decay searches offer a novel avenue for the direct detection of the hidden antibaryonic dark matter sea.

  16. Chile: pioneer in deregulation of the electric power sector

    SciTech Connect

    Rudnick, H. )

    1994-06-01

    This article examines the deregulation of the electric power sector in Chile. Chile was the leader in Latin America in the restructuring of the electric power sector, and its case merits particular analysis. Although a small system (70% of installed capacity is hydroelectric with 2,800 MW maximum demand in 1993), its development has been observed with interest by many institutions, particularly by the World Bank and most recently by other Latin American countries, and several countries have followed its steps. The Chilean 1982 electricity law was a worldwide pioneer in deregulating the electric power sector to create market conditions where generators compete to provide electrical energy to large consumers, sharing a transmission system open to all and paying fees for that system. The law formalized what had taken place in the country since 1978, several years before market approaches were formulated in the US and implemented in the United Kingdom.

  17. Priority mitigation measures in non-energy sector in Kazakstan

    SciTech Connect

    Mizina, S.V.; Pilifosova, O.V.; Gossen, E.F.

    1996-12-31

    Fulfilling the Commitments on UN FCCC through the U.S. Country Studies Program, Kazakstan has developed the national GHG Inventory, vulnerability and adaptation assessment and estimated the possibility of mitigation measures in certain sectors. Next step is developing National Climate Change Action Plan. That process includes such major steps as setting priorities in mitigation measures and technologies, their comprehensive evaluation, preparation implementation strategies, developing the procedure of incorporation of the National Action Plan into other development plans and programs. This paper presents programs and measures that can reduce GHG emissions in non-energy sector. Measures in land-use change and forestry, agriculture and coal mining are considered. Current situation in non-energy sector of Kazakstan is discussed. The amount of GHG emissions reduction and cost analysis presented in this paper was developed with the use of IPCC recommendations.

  18. Competences in demand within the Spanish agricultural engineering sector

    NASA Astrophysics Data System (ADS)

    Perdigones, Alicia; Valera, Diego Luis; Moreda, Guillermo Pedro; García, Jose Luis

    2014-09-01

    The Rural Engineering Department (Technical University of Madrid) ran three competence surveys during the 2006-2007 and 2007-2008 academic years and evaluated: (1) the competences gained by agricultural engineer's degree and agricultural technical engineer's degree students (360 respondents); (2) the competences demanded by agricultural employers (50 farming sector employers); (3) competences required by farming sector professionals and former students (70 professionals). The surveys show significant differences between what competences agricultural employers require of graduates and the competences they acquire during their agricultural engineering degree courses. Recruiters are looking for generic competences such as the ability to coordinate groups and place less importance on knowledge of engineering, biology, applied economics and legislation. Of the computer-related competences, those most in demand by sector professionals were related to the use of Microsoft Office/Excel (used by 79% of professionals). Surveys were used to redesign some subjects of the degrees.

  19. Impacts of climate change on the global forest sector

    USGS Publications Warehouse

    Perez-Garcia, J.; Joyce, L.A.; McGuire, A.D.; Xiao, X.

    2002-01-01

    The path and magnitude of future anthropogenic emissions of carbon dioxide will likely influence changes in climate that may impact the global forest sector. These responses in the global forest sector may have implications for international efforts to stabilize the atmospheric concentration of carbon dioxide. This study takes a step toward including the role of global forest sector in integrated assessments of the global carbon cycle by linking global models of climate dynamics, ecosystem processes and forest economics to assess the potential responses of the global forest sector to different levels of greenhouse gas emissions. We utilize three climate scenarios and two economic scenarios to represent a range of greenhouse gas emissions and economic behavior. At the end of the analysis period (2040), the potential responses in regional forest growing stock simulated by the global ecosystem model range from decreases and increases for the low emissions climate scenario to increases in all regions for the high emissions climate scenario. The changes in vegetation are used to adjust timber supply in the softwood and hardwood sectors of the economic model. In general, the global changes in welfare are positive, but small across all scenarios. At the regional level, the changes in welfare can be large and either negative or positive. Markets and trade in forest products play important roles in whether a region realizes any gains associated with climate change. In general, regions with the lowest wood fiber production cost are able to expand harvests. Trade in forest products leads to lower prices elsewhere. The low-cost regions expand market shares and force higher-cost regions to decrease their harvests. Trade produces different economic gains and losses across the globe even though, globally, economic welfare increases. The results of this study indicate that assumptions within alternative climate scenarios and about trade in forest products are important factors

  20. Electricity savings potentials in the residential sector of Bahrain

    SciTech Connect

    Akbari, H.; Morsy, M.G.; Al-Baharna, N.S.

    1996-08-01

    Electricity is the major fuel (over 99%) used in the residential, commercial, and industrial sectors in Bahrain. In 1992, the total annual electricity consumption in Bahrain was 3.45 terawatt-hours (TWh), of which 1.95 TWh (56%) was used in the residential sector, 0.89 TWh (26%) in the commercial sector, and 0.59 TWh (17%) in the industrial sector. Agricultural energy consumption was 0.02 TWh (less than 1%) of the total energy use. In Bahrain, most residences are air conditioned with window units. The air-conditioning electricity use is at least 50% of total annual residential use. The contribution of residential AC to the peak power consumption is even more significant, approaching 80% of residential peak power demand. Air-conditioning electricity use in the commercial sector is also significant, about 45% of the annual use and over 60% of peak power demand. This paper presents a cost/benefit analysis of energy-efficient technologies in the residential sector. Technologies studied include: energy-efficient air conditioners, insulating houses, improved infiltration, increasing thermostat settings, efficient refrigerators and freezers, efficient water heaters, efficient clothes washers, and compact fluorescent lights. We conservatively estimate a 32% savings in residential electricity use at an average cost of about 4 fils per kWh. (The subsidized cost of residential electricity is about 12 fils per kWh. 1000 fils = 1 Bahrain Dinar = US$ 2.67). We also discuss major policy options needed for implementation of energy-efficiency technologies.

  1. [Eco-efficiency of industry sectors for China].

    PubMed

    Mao, Jian-Su; Zeng, Run; Du, Yan-Chun; Jiang, Pan

    2010-11-01

    Industry is the main source of resource consumption and environmental emissions of China, and the analyzing of eco-efficiencies for industrial sectors may provide essential information for the restructure of industrial system and the improvement of environmental quality of China. The industry composition was analyzed and the relationship between the industry and its environment was established. The energy consumption and the main environmental emissions such as wastewater, solid waste, industry SO2, smog, dust were chosen as the environmental impact categories, the corresponding eco-efficiencies of industry were defined and estimated for China in 2007. The results are as follows: the energy efficiency is 615.5 x 10(4) yuan x ktce(-1), the wastewater and solid waste related eco-efficiencies are 54.3 x 10(4) yuan x kt(-1) and 1.9 x 10(4) yuan x t(-1), respectively; industry SO2, smog, dust related eco-efficiencies are 59.6 x 10(4), 169.2 x 10(4) and 184.6 x 10(4) yuan x t(-1), respectively. The eco-efficiencies of 39 industry sectors were analyzed extensively and the results showed that, the distribution of industrial sectors in above eco-efficiencies is uneven, and the order of industrial sector in industry will vary with industry sector and eco-efficiency category. Meanwhile, for the same category of eco-efficiency, the values for different industry sectors may change from centuplicate to several thousand folds, therefore a great possibility for the improvement of industry eco-efficiency is exist in the restructure of industry system.

  2. Exploring corruption in the South African health sector.

    PubMed

    Rispel, Laetitia C; de Jager, Pieter; Fonn, Sharon

    2016-03-01

    Recent scholarly attention has focused on weak governance and the negative effects of corruption on the provision of health services. Employing agency theory, this article discusses corruption in the South African health sector. We used a combination of research methods and triangulated data from three sources: Auditor-General of South Africa reports for each province covering a 9-year period; 13 semi-structured interviews with health sector key informants and a content analysis of print media reports covering a 3-year period. Findings from the Auditor-General reports showed a worsening trend in audit outcomes with marked variation across the nine provinces. Key-informants indicated that corruption has a negative effect on patient care and the morale of healthcare workers. The majority of the print media reports on corruption concerned the public health sector (63%) and involved provincial health departments (45%). Characteristics and complexity of the public health sector may increase its vulnerability to corruption, but the private-public binary constitutes a false dichotomy as corruption often involves agents from both sectors. Notwithstanding the lack of global validated indicators to measure corruption, our findings suggest that corruption is a problem in the South African healthcare sector. Corruption is influenced by adverse agent selection, lack of mechanisms to detect corruption and a failure to sanction those involved in corrupt activities. We conclude that appropriate legislation is a necessary, but not sufficient intervention to reduce corruption. We propose that mechanisms to reduce corruption must include the political will to run corruption-free health services, effective government to enforce laws, appropriate systems, and citizen involvement and advocacy to hold public officials accountable. Importantly, the institutionalization of a functional bureaucracy and public servants with the right skills, competencies, ethics and value systems and whose

  3. A carbon footprint simulation model for the cork oak sector.

    PubMed

    Demertzi, Martha; Paulo, Joana Amaral; Arroja, Luís; Dias, Ana Cláudia

    2016-10-01

    In the present study, a simulation model for the calculation of the carbon footprint of the cork oak sector (CCFM) is developed for the first time. A life cycle approach is adopted including the forest management, manufacturing, use and end-of-life stages. CCFM allows the user to insert the cork type used as raw material and its respective quantity and the distances in-between the various stages. The user can choose among different end-of-life destination options for the used cork products. The option of inserting different inputs, allows the use of the present simulation model for different cork oak systems, in different countries and with different conditions. CCFM allows the identification of the stages and products with the greatest carbon footprint and thus, a better management of the sector from an environmental perspective. The Portuguese cork oak sector is used as an application example of the model. The results obtained showed that the agglomeration industry is the hotspot for the carbon footprint of the cork sector mainly due to the production of the resins that are mixed with the cork granules for the production of agglomerated cork products. The consideration of the biogenic carbon emissions and sequestration of carbon at the forest in the carbon footprint, resulted to a great decrease of the sector's carbon footprint. Future actions for improvement are suggested in order to decrease the carbon footprint of the entire cork sector. It was found that by decreasing by 10% the emission factor of the agglomeration and transformation industries, substituting the transport trucks by more recent ones and by decreasing by 10% the cork products reaching the landfilling end-of-life destinations (while increasing the quantities reaching incineration and recycling), a decrease of the total CF (excluding the biogenic emissions and sequestration) of the entire cork industry by 10% can be achieved.

  4. Plasmon coupling in the double-sector structure

    NASA Astrophysics Data System (ADS)

    Qi, Jianxia; Miao, Runcai; Dong, Jun

    2017-03-01

    A silver nanostructure consisting of double sectors is proposed in this paper. In addition, the plasmon resonance and electric field enhancement have been investigated theoretically. It is found that, in this structure, the multiple resonances produce, which is tunable by the parameter of the structure. The localized electromagnetic fields can be produced at the tips of the structure. In addition, the enhanced electromagnetic fields can be observed between the sectors in a wide scale at the lower energy peak. The result of the investigation has great significance for the production of practical nanostructures and the improvement of possible applications.

  5. Dark Forces and Dark Matter in a Hidden Sector

    NASA Astrophysics Data System (ADS)

    Andreas, Sarah

    2012-01-01

    Hidden sectors in connection with GeV-scale dark forces and dark matter are not only a common feature of physics beyond the Standard Model such as string theory and SUSY but are also phenomenologically of great interest regarding recent astrophysical observations. The hidden photon in particular is also searched for and constrained by laboratory experiments, the current status of which will be presented here. Furthermore, several models of hidden sectors containing in addition a dark matter particle will be examined regarding their consistency with the dark matter relic abundance and direct detection experiments.

  6. Infrastructure opportunities in South America: Energy sector. Export trade information

    SciTech Connect

    1995-06-01

    The report, conducted by CG/LA, Inc., was funded by the U.S. Trade and Development Agency. The report was assembled for the South American Infrastructure Conference held in New Orleans. It contains a regional overview of infrastructure activities in ten countries represented at the conference. Also covered are project listings in five sectors, including Energy, Transportation, Environment, Telecommunications, and Industry. The study covers TDA case studies as well as project financeability. The ten countries covered in the report include the following: Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Paraguay, Peru, Uruguay, and Venezuela. This volume focuses on the Energy Sector in South America.

  7. Iris sector heterochromia as a marker for neural crest disease.

    PubMed

    Brazel, S M; Sullivan, T J; Thorner, P S; Clarke, M P; Hunter, W S; Morin, J D

    1992-02-01

    A 6-month-old female infant with biopsy-proved Hirschsprung's disease had associated sector heterochromia of the irides. The association between sector heterochromia and Hirschsprung's disease has been previously reported and both conditions have been ascribed to neural crest defects. Histologic characteristics of the ocular involvement have not previously been reported, to our knowledge. Histopathologic examination of the globes revealed decreased iris stroma, decreased pigmentation in the anterior stroma, and reduced numbers of pigment-producing cells in the affected areas. Both the ocular and gastrointestinal findings reflect abnormalities in tissues of neural crest origin.

  8. Non-linear analysis of moderately thick sector plates

    NASA Astrophysics Data System (ADS)

    Nath, Y.; Sharda, H. B.; Sharma, Ashish

    2005-10-01

    Non-linear static analysis of moderately thick sector plates under uniformly distributed loading is presented. Using the first-order shear deformation theory and Von Karman type non-linearity, the governing equations of equilibrium are developed and expressed in terms of displacement components. The Chebyshev polynomial is used for spatial discretization of the differential equations. An iterative incremental approach based on Newton-Raphson method is used for the solution. Convergence study is carried out. Effects of annularity, thickness ratio, sector angle and boundary conditions are investigated. Results are compared with those available from the literature.

  9. Methodology for Modeling Building Energy Performance across the Commercial Sector

    SciTech Connect

    Griffith, B.; Long, N.; Torcellini, P.; Judkoff, R.; Crawley, D.; Ryan, J.

    2008-03-01

    This report uses EnergyPlus simulations of each building in the 2003 Commercial Buildings Energy Consumption Survey (CBECS) to document and demonstrate bottom-up methods of modeling the entire U.S. commercial buildings sector (EIA 2006). The ability to use a whole-building simulation tool to model the entire sector is of interest because the energy models enable us to answer subsequent 'what-if' questions that involve technologies and practices related to energy. This report documents how the whole-building models were generated from the building characteristics in 2003 CBECS and compares the simulation results to the survey data for energy use.

  10. Private Sector Initiative Between the U.S. and Japan

    SciTech Connect

    1998-09-30

    OAK-A258 Private Sector Initiative Between the U.S. and Japan. This report for calendar years 1993 through September 1998 describes efforts performed under the Private Sector Initiatives contract. The report also describes those efforts that have continued with private funding after being initiated under this contract. The development of a pyrochemical process, called TRUMP-S, for partitioning actinides from PUREX waste, is described in this report. This effort is funded by the Central Research Institute of Electric Power Industry (CRIEPI), KHI, the United States Department of Energy, and Boeing.

  11. Energy productivity in the industrial sector: an econometric analysis

    SciTech Connect

    Roop, J.M.

    1983-01-01

    Energy productivity and energy intensity within the industrial sector of the economy are examined. Results suggest that relative prices and other economic factors can explain much of the variation in both energy productivity and energy intensity for manufacturing and mining and for the industrial sector as a whole. Cyclical factors, seasonal factors and trend variables are also useful in explaining variation in these data, both for annual and monthly time series. Of the variables examined, it appears that the relative price of energy is a highly significant factor in accounting for the difference between actual industrial energy intensity and that which might have been expected had pre-1973 trends continued.

  12. Sector field mass spectrometers in ICP-MS

    NASA Astrophysics Data System (ADS)

    Jakubowski, Norbert; Moens, Luc; Vanhaecke, Frank

    1998-11-01

    A new generation of sector field mass spectrometers, with improved analytical figures of merit at even lower prices, is commercially available, giving a strong impetus to the development of inductively coupled plasma mass spectrometry (ICP-MS) sector field instrument applications in the analytical community. It is the aim of this paper to give an overview of these instruments, to introduce some basic concepts, to discuss their peculiarities and performance, and to present some selected examples of analytical applications to demonstrate the `state of the art'.

  13. Privatizing responsibility: public sector reform under neoliberal government.

    PubMed

    Ilcan, Suzan

    2009-08-01

    In light of public sector reforms in Canada and elsewhere, this paper focuses on the shift of emphasis from social to private responsibilities and raises new questions about the forces of private enterprise and market-based partnerships. Under neoliberal governmental agendas, privatizing responsibility links to three main developments: the reconsideration of the relations of public and private; the mobilization of responsible citizenship; and the formation of a cultural mentality of rule that works alongside these developments. The research for this article is based on extensive analysis of policy documents and public sector reform initiatives, as well as interviews with Canadian federal public service employees.

  14. Creating Good Employment Opportunities for the Rural Sector

    PubMed Central

    Foster, Andrew D.

    2013-01-01

    This paper examines the potential for sector-specific productivity growth, human capital, credit markets, and infrastructure to contribute to the development of stable, well-paid employment in rural areas of low-income countries. Particular emphasis is placed on the way that different sectors of the rural economy interact with each other and with local and regional product markets. A simple theoretical framework and descriptive analysis of panel data from India suggests that more emphasis should be placed on increasing the production of goods that incorporate local agricultural products as inputs. PMID:25883938

  15. Building a Comprehensive Mill-Level Database for the Industrial Sectors Integrated Solutions (ISIS) Model of the U.S. Pulp and Paper Sector

    EPA Science Inventory

    The Industrial Sectors Integrated Solutions (ISIS) model for the pulp and paper sector is currently under development at the U.S. Environmental Protection Agency (EPA), and can be utilized to facilitate multi-pollutant sector-based analyses that are performed in conjunction with ...

  16. School Sector, School Poverty, and the Catholic School Advantage

    ERIC Educational Resources Information Center

    Hallinan, Maureen T.; Kubitschek, Warren N.

    2010-01-01

    Equality of educational opportunity is threatened by long-standing gaps in student achievement by race, gender, and student poverty, as well as by school sector and school poverty. The true magnitude of these gaps cannot be understood, however, unless these factors are considered simultaneously. While accounting for the effects of demographic…

  17. Hearing the signal of dark sectors with gravitational wave detectors

    NASA Astrophysics Data System (ADS)

    Jaeckel, Joerg; Khoze, Valentin V.; Spannowsky, Michael

    2016-11-01

    Motivated by advanced LIGO (aLIGO)'s recent discovery of gravitational waves, we discuss signatures of new physics that could be seen at ground- and space-based interferometers. We show that a first-order phase transition in a dark sector would lead to a detectable gravitational wave signal at future experiments, if the phase transition has occurred at temperatures few orders of magnitude higher than the electroweak scale. The source of gravitational waves in this case is associated with the dynamics of expanding and colliding bubbles in the early universe. At the same time we point out that topological defects, such as dark sector domain walls, may generate a detectable signal already at aLIGO. Both bubble and domain-wall scenarios are sourced by semiclassical configurations of a dark new physics sector. In the first case, the gravitational wave signal originates from bubble wall collisions and subsequent turbulence in hot plasma in the early universe, while the second case corresponds to domain walls passing through the interferometer at present and is not related to gravitational waves. We find that aLIGO at its current sensitivity can detect smoking-gun signatures from domain-wall interactions, while future proposed experiments including the fifth phase of aLIGO at design sensitivity can probe dark sector phase transitions.

  18. Where Is the Xerox Corporation of the LIS Sector?

    ERIC Educational Resources Information Center

    Gilchrist, Alan; Brockman, John

    1996-01-01

    Discusses barriers to the implementation of quality management in the library and information science sector in Europe. Topics include Total Quality Management and other business experiences, an information quality infrastructure, supplier/customer relations, customer satisfaction, and a European Quality Model. (LRW)

  19. Measuring Systemic and Climate Diversity in Ontario's University Sector

    ERIC Educational Resources Information Center

    Piché, Pierre Gilles

    2015-01-01

    This article proposes a methodology for measuring institutional diversity and applies it to Ontario's university sector. This study first used hierarchical cluster analysis, which suggested there has been very little change in diversity between 1994 and 2010 as universities were clustered in three groups for both years. However, by adapting…

  20. Managing risk selection incentives in health sector reforms.

    PubMed

    Puig-Junoy, J

    1999-01-01

    The object of the paper is to review theoretical and empirical contributions to the optimal management of risk selection incentives ('cream skimming') in health sector reforms. The trade-off between efficiency and risk selection is fostered in health sector reforms by the introduction of competitive mechanisms such as price competition or prospective payment systems. The effects of two main forms of competition in health sector reforms are observed when health insurance is mandatory: competition in the market for health insurance, and in the market for health services. Market and government failures contribute to the assessment of the different forms of risk selection employed by insurers and providers, as the effects of selection incentives on efficiency and their proposed remedies to reduce the impact of these perverse incentives. Two European (Netherlands and Spain) and two Latin American (Chile and Colombia) case studies of health sector reforms are examined in order to observe selection incentives, their effects on efficiency and costs in the health system, and regulation policies implemented in each country to mitigate incentives to 'cream skim' good risks.

  1. GLOBAL CHANGE RESEARCH NEWS #5: HEALTH SECTOR ASSESSMENT

    EPA Science Inventory

    The Health Sector Assessment is one of the three levels of the assessment process that is intended to answer four questions: (1) What is the current status of the nation's health, and what are current stresses on our health? (2) How might climate change affect the country's healt...

  2. Rehabilitation Counseling in the Private Sector: Implications for Graduate Education.

    ERIC Educational Resources Information Center

    Sales, Amos

    1979-01-01

    There are specific skill areas which are not addressed in present masters degree programs which could be addressed in terms of developing an effective specialty area in rehabilitation counseling in the private sector. These areas include knowledge of workers compensation, basic concepts in insurance, and understanding of law. (CT)

  3. Institutionalization of Information Security: Case of the Indonesian Banking Sector

    ERIC Educational Resources Information Center

    Nasution, Muhamad Faisal Fariduddin Attar

    2012-01-01

    This study focuses on the institutionalization of information security in the banking sector. This study is important to pursue since it explicates the internalization of information security governance and practices and how such internalization develops an organizational resistance towards security breach. The study argues that information…

  4. Supported Employment in the Public Sector: Procedural Issues in Implementation.

    ERIC Educational Resources Information Center

    Rhodes, Larry; Drum, Charles

    1989-01-01

    A survey of 10 states indicated the presence of hiring procedures that discourage or limit public-sector supported employment for persons having severe disabilities. Survey results, and recommendations for state system change to promote supported employment, are presented in 4 areas: civil service examination requirements, job classification…

  5. Private Sector Views of Vocational Education: A Statewide Employer Survey.

    ERIC Educational Resources Information Center

    Owens, Thomas R.; Monthey, Wanda

    A study examined the views of private sector employers in Oregon on vocational education. During the study, researchers mailed questionnaires to a stratified random sample of 1,500 employers throughout Oregon. In addition, they surveyed another 140 employers who were identified as hiring the largest numbers of vocational education completers in…

  6. 50 CFR 679.62 - Inshore sector cooperative allocation program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... vessel cooperative that applies for and receives an AFA inshore cooperative fishing permit under § 679.4... an official AFA inshore cooperative catch history for every inshore-sector endorsed AFA catcher... the vessel's official AFA inshore cooperative catch history for each subarea. A vessel's best 2...

  7. Sector strength and efficiency on developed and emerging financial markets

    NASA Astrophysics Data System (ADS)

    Fiedor, Paweł

    2014-11-01

    In this paper we analyse the importance of sectors and market efficiency on developed and emerging financial markets. To perform this we analyse New York Stock Exchange between 2004 and 2013 and Warsaw Stock Exchange between 2000 and 2013. To find out the importance of sectors we construct minimal spanning trees for annual time series consisting of daily log returns and calculate centrality measures for all stocks, which we then aggregate by sectors. Such analysis is of interest to analysts for whom the knowledge of the influence of particular groups of stocks to the market behaviour is crucial. We also analyse the predictability of price changes on those two markets formally, using the information-theoretic concept of entropy rate, to find out the differences in market efficiency between a developed and an emerging market, and between sectors themselves. We postulate that such analysis is important to the study of financial markets as it can contribute to the profitability of investments, particularly in the case of algorithmic trading.

  8. An overview of changing agendas in health sector reforms.

    PubMed

    Standing, Hilary

    2002-11-01

    This paper discusses health sector reforms and what they have meant for sexual and reproductive health advocacy in low-income countries. Beginning in the late 1980s, it outlines the main macro-economic shifts and policy trends which affect countries dependent on external aid and the main health sector reforms taking place. It then considers the implications of successive macro-economic and reform agendas for reproductive and sexual health advocacy. International debate today is focused on the conditions necessary for socio-economic development and the role of governments in these, and how to improve the performance of health sector bureaucracies and delivery systems. A critical challenge is how to re-negotiate the policy and financial space for sexual and reproductive health services within national health systems and at international level. Advocacy for sexual and reproductive health has to tread the line between a vision of reproductive health for all and action on priority conditions, which means articulating an informed view on needs and priorities. In pressing for greater funding for reproductive health, advocates need to find an appropriate balance between concern with health systems strengthening and service delivery and programmes, and create alliances with progressive health sector reformers.

  9. The Social Construction of Skills: A Hospitality Sector Perspective

    ERIC Educational Resources Information Center

    Baum, Tom

    2008-01-01

    This paper addresses the nature of skills in service work with specific reference to international tourism and its hospitality subsector. It explores the role of experiential factors (cultural, emotional and aesthetic) in equipping those entering work in the sector. The specific context of work in less developed countries and within migrant labour…

  10. Insurance Sector Dynamics: Towards Transformation into Learning Organization

    ERIC Educational Resources Information Center

    Barkur, Gopalakrishna; Varambally, K. V. M.; Rodrigues, Lewlyn L. R.

    2007-01-01

    Purpose: The purpose of this research is to study the influence of five critical factors on service quality in the insurance sector. Having studied the influence of these critical factors, an attempt has been made to obtain a generic solution to enhance the quality of service by proposing a holistic framework of learning organization. As…

  11. Reforming Mexico’s Energy Sector to Enhance Stability

    DTIC Science & Technology

    2011-10-27

    requirement to reform Mexico’s energy sector. Subsequent analysis demonstrates government ownership of Petroleos Mexico ( Pemex ) is the fundamental... Pemex , stability 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON Chairman... Pemex and Stability 8 Conclusions and Recommendations 13 Policy Implications 16 Bibliography

  12. Six Questions about The World Bank's 2020 Education Sector Strategy

    ERIC Educational Resources Information Center

    Shafiq, M. Najeeb

    2011-01-01

    Based on interviews with World Bank staff in April 2011, this article answers six questions about the World Bank's Education Sector Strategy 2020 (ESS 2020): (1) What is the ESS 2020? (2) What is it not? (3) How was the development process of the ESS 2020 different from that of past Strategies? (4) How are the policy recommendations of the ESS…

  13. Stability of the sectored morphology of polymer crystallites

    NASA Astrophysics Data System (ADS)

    Alageshan, Jaya Kumar; Hatwalne, Yashodhan; Muthukumar, Murugappan

    2016-09-01

    When an entangled interpenetrating collection of long flexible polymer chains dispersed in a suitable solvent is cooled to low enough temperatures, thin lamellar crystals form. Remarkably, these lamellae are sectored, with several growth sectors that have differing melting temperatures and growth kinetics, eluding so far an understanding of their origins. We present a theoretical model to explain this six-decade-old challenge by addressing the elasticity of fold surfaces of finite-sized lamella in the presence of disclination-type topological defects arising from anisotropic line tension. Entrapment of a disclination defect in a lamella results in sectors separated by walls, which are soliton solutions of a two-dimensional elliptic sine-Gordon equation. For flat square morphologies, exact results show that sectored squares are more stable than plain squares if the dimensionless anisotropic line tension parameter α =γa n/√{h4Kϕ } (γa n = anisotropic line tension, h4 = fold energy parameter, Kϕ = elastic constant for two-dimensional orientational deformation) is above a critical value, which depends on the size of the square.

  14. Exploring Ohio's Private Education Sector. School Survey Series

    ERIC Educational Resources Information Center

    Catt, Andrew D.

    2014-01-01

    Exploring Ohio's Private Education Sector is the second entry in the Friedman Foundation for Educational Choice's "School Survey Series." This report synthesizes information on Ohio's private schools collected by the U.S. Department of Education and the Ohio Department of Education (ODE). Two appendices provide supplementary tables and…

  15. Recent Progress in Search for Dark Sector Signatures

    NASA Astrophysics Data System (ADS)

    Deliyergiyev, Maksym

    2016-01-01

    Many difficulties are encountered when attempting to pinpoint a common origin for several observed astrophysical anomalies, and when assessing their tension with existing exclusion limits. These include systematic uncertainties affecting the operation of the detectors, our knowledge of their response, astrophysical uncertainties, and the broad range of particle couplings that can mediate interaction with a detector target. Particularly interesting astrophysical evidence has motivated a search for dark-photon, and focused our attention on a Hidden Valleys model with a GeV-scale dark sector that produces exciting signatures. Results from recent underground experiments are also considered. There is a `light' hidden sector (dark sector), present in many models of new physics beyond the Standard Model, which contains a colorful spectrum of new particles. Recently, it has been shown that this spectrum can give rise to unique signatures at colliders when the mass scale in the hidden sector is well below a TeV; as in Hidden Valleys, Stueckelberg extensions, and Unparticle models. These physics models produce unique signatures of collimated leptons at high energies. By studying these ephemeral particles we hope to trace the history of the Universe. Our present theories lead us to believe that there is something new just around the corner, which should be accessible at the energies made available by modern colliders.

  16. Industrial Sector Energy Efficiency Modeling (ISEEM) Framework Documentation

    SciTech Connect

    Karali, Nihan; Xu, Tengfang; Sathaye, Jayant

    2012-12-12

    The goal of this study is to develop a new bottom-up industry sector energy-modeling framework with an agenda of addressing least cost regional and global carbon reduction strategies, improving the capabilities and limitations of the existing models that allows trading across regions and countries as an alternative.

  17. Industrial Rehabilitation in the Public Sector: The Ohio Experience.

    ERIC Educational Resources Information Center

    Olsheski, Jerry; Growick, Bruce

    In 1979, Ohio passed a law creating a Rehabilitation Division within its Industrial Commission and authorizing the building of two comprehensive rehabilitation centers to serve disabled workers. Ohio provides industrial rehabilitation services almost entirely through the public sector. This paper describes industrial rehabilitation policies and…

  18. 76 FR 26603 - Reorganization of Sector North Carolina; Technical Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... Macon, NC, with a Marine Safety Unit (MSU) in Wilmington, NC, responsible for the Cape Fear River Marine... the Cape Fear River Marine Inspection and COTP Zones. The Coast Guard has now reorganized Sector North... Fear River Marine Inspection and COTP Zones. This reorganization is intended to improve...

  19. Information Studies for the Business Sector in Spanish Universities

    ERIC Educational Resources Information Center

    Canavate, Antonio Munoz; Hipola, Pedro

    2008-01-01

    The management of information in the business world constitutes a single consolidated area within undergraduate and graduate study programs in Librarianship and Information Science. This article describes information studies for the business sector within Spain, including the university programs known as Diplomatura in Librarianship and…

  20. Information Technology Training: Practices of Leading Private Sector Companies.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    The General Accounting Office (GAO) examined private-sector workforce training practices for information technology (IT) and non-IT professionals. Data were collected from the following sources: a literature review; discussions with academic and professional authorities; interviews with executives and managers at leading companies regarding their…

  1. School Effectiveness within the Public and Private Sectors.

    ERIC Educational Resources Information Center

    Willms, J. Douglas

    1984-01-01

    gh School and Beyond data are examined using an approach to multilevel data analysis that shows the diversity in school effectiveness within the public and private sectors and provides estimates of private schooling effects for different types of students in schools serving different demographic populations. (PN)

  2. Steering the South African Higher Education Sector towards Transformation

    ERIC Educational Resources Information Center

    Ntshoe, Isaac; De Villiers, Pierre

    2008-01-01

    This article explores the extent to which funding is used to steer the public higher education sector towards meeting the social, political and economic imperatives of post-1994 South Africa. It argues that the design of the funding framework influenced the direction of higher education after 1994, and that funding mechanisms explicitly or…

  3. Competition and Cooperation in South Africa's Biotechnology Sector

    ERIC Educational Resources Information Center

    Klerck, Gilton

    2005-01-01

    This article asserts that the normative, institutional and policy framework of an economy moulds the structure and performance of its innovation system. Three case studies of industry?higher education partnerships in South Africa's biotechnology sector challenge both the notion of a simple convergence within and between national innovation systems…

  4. 50 CFR 270.14 - Update of sector participant data.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Update of sector participant data. 270.14 Section 270.14 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISH AND SEAFOOD PROMOTION SPECIES-SPECIFIC SEAFOOD MARKETING...

  5. 50 CFR 270.6 - Sector participants eligible to vote.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Sector participants eligible to vote. 270.6 Section 270.6 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISH AND SEAFOOD PROMOTION SPECIES-SPECIFIC...

  6. White dwarfs constraints on dark sector models with light particles

    SciTech Connect

    Ubaldi, Lorenzo

    2014-06-24

    The white dwarf luminosity function is well understood in terms of standard model physics and leaves little room for exotic cooling mechanisms related to the possible existence of new weakly interacting light particles. This puts significant constraints on the parameter space of models that contain a massive dark photon and light dark sector particles.

  7. 77 FR 43498 - Federal Sector Equal Employment Opportunity

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1614 RIN Number 3046-AA73 Federal Sector Equal Employment Opportunity AGENCY: Equal Employment Opportunity Commission. ACTION: Final rule. SUMMARY: The Equal Employment Opportunity...

  8. The Social Cohesion Role of the Public Sector

    ERIC Educational Resources Information Center

    Capshaw, N. Clark

    2005-01-01

    Social cohesion, the "glue" that keeps a society together, is influenced by the various sectors or "pillars" of that society-educational institutions, social and religious institutions, business institutions, and government. In this article, the effect of the three branches of government (executive, legislative, and judicial) on social cohesion is…

  9. Corruption in Education Sector Development: A Suggestion for Anticipatory Strategy.

    ERIC Educational Resources Information Center

    Tanaka, Shinichiro

    2001-01-01

    Proposes an anticipatory strategy that will help protect education sector development from corruption. The strategy, which may exist as a "hidden agenda" within a project, focuses on diagnosing rather than redressing a system thought to be corrupt, adopting prevention rather than punishment, informal rather than formal approaches, and…

  10. Evaluating NASA Technology Programs in Terms of Private Sector Impacts

    NASA Technical Reports Server (NTRS)

    Greenberg, J. S.

    1984-01-01

    NASA is currently developing spacecraft technology for application to NASA scientific missions, military missions and commercial missions which are part of or form the basis of private sector business ventures. The justification of R&D programs that lead to spacecraft technology improvements encompasses the establishment of the benefits in terms of improved scientific knowledge that may result from new and/or improved NASA science missions, improved cost effectiveness of NASA and DOD missions and new or improved services that may be offered by the private sector (for example communications satellite services). It is with the latter of these areas that attention will be focused upon. In particular, it is of interest to establish the economic value of spacecraft technology improvements to private sector communications satellite business ventures. It is proposed to assess the value of spacecraft technology improvements in terms of the changes in cash flow and present value of cash flows, that may result from the use of new and/or improved spacecraft technology for specific types of private sector communications satellite missions (for example domestic point-to-point communication or direct broadcasting). To accomplish this it is necessary to place the new and/or improved technology within typical business scenarios and estimate the impacts of technical performance upon business and financial performance.

  11. Liberalization in the Danish waste sector: an institutional perspective.

    PubMed

    Kørnøv, Lone; Hill, Amanda Louise; Busck, Ole; Løkke, Søren

    2016-12-01

    The push for creating a more competitive and liberalized system for traditional public services, including waste management, has been on the European agenda since the late 1980s. In 2008, changes were made in EU waste legislation allowing source-separated industrial/commercial waste that is suitable for incineration to be traded within the European market. This change has had broad implications for the Danish waste sector, which is characterized by institutionalized municipal control with all streams of waste and municipal ownership of the major treatment facilities allowing the municipal sector to integrate combustible waste in local heat and power generation. This article, applying an institutional approach, maps the institutions and actors of the Danish waste sector and analyses how the regulatory as well as normative pressure to liberalize has been met and partly neutralized in the institutional and political context. The new Danish regulation of 2010 has thus accommodated the specific requirement for liberalization, but in fact only represents a very small step towards a market-based waste management system. On the one hand, by only liberalizing industrial/commercial waste, the Danish Government chose to retain the main features of the established waste system favouring municipal control and hence the institutionalized principles of decentralized enforcement of environmental legislation as well as welfare state considerations. On the other hand, this has led to a technological and financial deadlock, particularly when it comes to reaching the recycling targets of EU, which calls for further adjustments of the Danish waste sector.

  12. Incentives and Their Dynamics in Public Sector Performance Management Systems

    ERIC Educational Resources Information Center

    Heinrich, Carolyn J.; Marschke, Gerald

    2010-01-01

    We use the principal-agent model as a focal theoretical frame for synthesizing what we know, both theoretically and empirically, about the design and dynamics of the implementation of performance management systems in the public sector. In this context, we review the growing body of evidence about how performance measurement and incentive systems…

  13. Public Sector Transformation, Racial Inequality and Downward Occupational Mobility

    ERIC Educational Resources Information Center

    Wilson, George; Roscigno, Vincent J.; Huffman, Matt L.

    2013-01-01

    New "governance" reforms entailing shifts toward privatization have permeated the public sector over the last decade, possibly affecting workplace-based attainments. We examine the consequences of this reform for African American men, who during the civil rights era reached relative parity with whites. We analyze race-based inequities on one…

  14. Understanding Student Satisfaction and Loyalty in the UAE HE Sector

    ERIC Educational Resources Information Center

    Fernandes, Cedwyn; Ross, Kieran; Meraj, Mohammad

    2013-01-01

    Purpose: The purpose of this paper is to verify and estimate the impact of the antecedents of Programme satisfaction and to explore its link with student loyalty in the higher education (HE) sector in the United Arab Emirates (UAE). Design/methodology/approach: A Programme Experience Questionnaire (PEQ) was developed, based on the National Student…

  15. A proposed framework of big data readiness in public sectors

    NASA Astrophysics Data System (ADS)

    Ali, Raja Haslinda Raja Mohd; Mohamad, Rosli; Sudin, Suhizaz

    2016-08-01

    Growing interest over big data mainly linked to its great potential to unveil unforeseen pattern or profiles that support organisation's key business decisions. Following private sector moves to embrace big data, the government sector has now getting into the bandwagon. Big data has been considered as one of the potential tools to enhance service delivery of the public sector within its financial resources constraints. Malaysian government, particularly, has considered big data as one of the main national agenda. Regardless of government commitment to promote big data amongst government agencies, degrees of readiness of the government agencies as well as their employees are crucial in ensuring successful deployment of big data. This paper, therefore, proposes a conceptual framework to investigate perceived readiness of big data potentials amongst Malaysian government agencies. Perceived readiness of 28 ministries and their respective employees will be assessed using both qualitative (interview) and quantitative (survey) approaches. The outcome of the study is expected to offer meaningful insight on factors affecting change readiness among public agencies on big data potentials and the expected outcome from greater/lower change readiness among the public sectors.

  16. Impacts of Increased Diesel Penetration in the Transportation Sector, The

    EIA Publications

    1998-01-01

    Requested by the Office of Energy Efficiency and Renewable Energy, U.S. Department of Energy. Analyzes the impacts on petroleum prices, demand, and refinery operations of a projected increase in demand for diesel fuel stemming from greater penetration of diesel-fueled engines in the light-duty vehicle fleet of the U.S. transportation sector.

  17. Wage Differentials Between Federal Government and Private Sector Workers.

    ERIC Educational Resources Information Center

    Smith, Sharon Patricia

    This study examined the earnings and wage rate differentials between Federal government and private sector workers in 1960 and 1970 to consider the comparability of these workers and the application of the Comparability Doctrine in Federal pay policy during that period. Two types of earnings and wage rate equations were estimated by ordinary least…

  18. Third Sector Involvement in Public Education: The Israeli Case

    ERIC Educational Resources Information Center

    Berkovich, Izhak; Foldes, Vincent Jonathan

    2012-01-01

    Purpose: The purpose of this article is to address the involvement of third sector organizations in state public education in Israel, with emphasis on the decision-making processes affecting the geographic distribution of service provision. Design/methodology/approach: A collective case study approach was used to investigate non-governmental…

  19. Public sector administration of ecological economics systems using mediated modeling.

    PubMed

    van den Belt, Marjan; Kenyan, Jennifer R; Krueger, Elizabeth; Maynard, Alison; Roy, Matthew Galen; Raphael, Ian

    2010-01-01

    In today's climate of government outsourcing and multiple stakeholder involvement in public sector management and service delivery, it is more important than ever to rethink and redesign the structure of how policy decisions are made, implemented, monitored, and adapted to new realities. The traditional command-and-control approach is now less effective because an increasing amount of responsibility to deliver public goods and services falls on networks of nongovernment agencies. Even though public administrators are seeking new decision-making models in an increasingly more complex environment, the public sector currently only sparsely utilizes Mediated Modeling (MM). There is growing evidence, however, that by employing MM and similar tools, public interest networks can be better equipped to deal with their long-term viability while maintaining the short-term needs of their clients. However, it may require a shift in organizational culture within and between organizations to achieve the desired results. This paper explores the successes and barriers to implementing MM and similar tools in the public sector and offers insights into utilizing them through a review of case studies and interdisciplinary literature. We aim to raise a broader interest in MM and similar tools among public sector administrators at various administrative levels. We focus primarily, but not exclusively, on those cases operating at the interface of ecology and socio-economic systems.

  20. Teaching Chinese Students: Understanding Their Public Sector Paradigm

    ERIC Educational Resources Information Center

    Conrad, Cynthia; Coleman, Charles

    2011-01-01

    Teaching Chinese students in an American university can be both challenging and rewarding. Cultural and language differences can lead to some superficial confusion and interpretational problems. However, the vast differences in the ways Chinese students view the role of the public sector, as compared to the US, can mean that the instructors and…

  1. Political and Academic Linkages in Public Sector Policymaking

    ERIC Educational Resources Information Center

    Hill, LaVerne Williamson

    2006-01-01

    Decision making in the public sector encompasses many topics of interest to the academic researcher--environmental issues, health and human services, budget planning, and so on. Expertise in data collection and analysis is critical to the policy-making process and can be provided by academic researchers. But the "real world" policymaker…

  2. Terrorism and Security Issues Facing the Water Infrastructure Sector

    DTIC Science & Technology

    2010-03-16

    design, deploy, and test biological or other contamination warning systems at drinking water systems (see discussion of the Water Sector Initiative ( WSI ...on page 7). The FY2011 budget states that five full-scale pilots have been established and that future funding for WSI will be used for evaluation

  3. Private Sector Involvement in Urban School Reform. Emerging Themes

    ERIC Educational Resources Information Center

    Research for Action, 2004

    2004-01-01

    This document presents findings on the impact of privatization to date at a meeting at the Ford Foundation co hosted by the William Penn Foundation, Carnegie Corporation of New York, and Ford. Increasingly, the private sector (both for-profit and non-profit) is providing resources and alternative delivery models for urban public schools. Beyond…

  4. Constructions of Professional Identity in a Dynamic Higher Education Sector

    ERIC Educational Resources Information Center

    Lewis, Kenton

    2014-01-01

    The expansion and specialisation of "non-academic" higher education roles, in response to increased regulation, monitoring and measurement of the sector, can be attributed to a rise in neoliberal manageralism and globalisation. Such changes have challenged the professional status of the academy, potentially…

  5. The Practice of Evaluation in Public Sector Contexts: A Response

    ERIC Educational Resources Information Center

    Chouinard, Jill Anne

    2013-01-01

    In the original paper, it was argued that while there is an array of methods and methodologies available, their use is delimited by the culture of accountability that prevails in public sector institutions, a fact that is particularly problematic given the complexity and diversity of evaluation contexts today. This short rejoinder, to responses…

  6. Retrieval Bargaining: A Guide for Public Sector Labor Negotiations.

    ERIC Educational Resources Information Center

    Neal, Richard G.

    Retrieval bargaining is the process of removing, through collective bargaining, benefits won by employees in previous negotiations. This document treats the retrieval bargaining process, explaining first the factors that could make such cutback management techniques necessary in the public sector, including federal funding reductions, inflationary…

  7. 78 FR 39533 - Power Sector Carbon Pollution Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ... country, we can continue our progress in reducing power plant pollution, thereby improving public health... reduce power plant carbon pollution, building on actions already underway in States and the power sector, I hereby direct the following: Section 1. Flexible Carbon Pollution Standards for Power Plants....

  8. Compensation Rules for Climate Policy in the Electricity Sector

    ERIC Educational Resources Information Center

    Burtraw, Dallas; Palmer, Karen

    2008-01-01

    Most previous cap and trade programs have distributed emission allowances for free to incumbent producers. However, in the electricity sector the value of CO[subscript 2] allowances may be far in excess of costs to industry and giving them away to firms diverts allowance value from other purposes. Using a detailed simulation model, this paper…

  9. Information Technology and Value Creation in the Public Sector Organizations

    ERIC Educational Resources Information Center

    Pang, Min-Seok

    2011-01-01

    In this dissertation, I study the performance impact of information technology (IT) investments in the public sector. IT has been one of the key assets in public administration since the early MIS era. Even though the information systems (IS) discipline has witnessed a considerable amount of research efforts on the subject of IT business value for…

  10. Online Tutoring and Emotional Labour in the Private Sector

    ERIC Educational Resources Information Center

    Webb, Sue

    2012-01-01

    Purpose: What happens when computer software is designed to replace the teacher and the human role is to service the relationship between the software and the learner? Specifically, this paper aims to consider whether or not emotional labour is performed in contexts mediated by technology in the private sector. Design/methodology/approach: The…

  11. A New Approach to Grievance Handling in the Federal Sector

    ERIC Educational Resources Information Center

    Draznin, Julius N.

    1974-01-01

    A labor/management class, thought to be unique in the area of public sector labor relations and personnel work-study programs, its goal being to have each side come to know the other's position more clearly and with more understanding, is described. (Author/AJ)

  12. Is BTZ a separate superselection sector of CTMG?

    NASA Astrophysics Data System (ADS)

    Deser, S.; Franklin, J.

    2010-10-01

    We exhibit exact solutions of (positive) matter coupled to original “wrong G-sign” cosmological TMG. They all evolve to conical singularity, rather than to black hole - here negative mass - BTZ. This provides evidence that the latter constitute a separate “superselection” sector, one that unlike in GR, is not reachable by physical sources.

  13. State Sector Strategies: The New Workforce Development in the USA

    ERIC Educational Resources Information Center

    Lakes, Richard D.

    2012-01-01

    Neoliberal governments consider global business competitiveness to be thwarted by costly bureaucratic regulation and programme duplication. In an effort to downsize the costs of operating a state, the governors now streamline job training functions via a coordinated workforce and economic development effort known as sector strategies, with…

  14. [Cross-sectoral quality assurance in ambulatory care].

    PubMed

    Albrecht, Martin; Loos, Stefan; Otten, Marcus

    2013-01-01

    Overcoming rigid sectoral segmentation in healthcare has also become a health policy target in quality assurance. With the Act to Enhance Competition in Statutory Health Insurance (GKV-WSG) coming into effect, quality assurance measures are to be designed in a cross-sectoral fashion for in- and outpatient sectors equally. An independent institution is currently mandated to develop specific quality indicators for eleven indications. For three of these operating tests have already been commissioned by the Federal Joint Committee. This article depicts the major results of a feasibility study, including a compliance cost estimate, for the aforementioned indications of cross-sectoral quality assurance (cQA). In conclusion, a number of both practical and conceptual basic challenges are still to be resolved prior to the full implementation of cQA, such as a sufficient specification to activate documentation requirements and an inspection system capable of separating actual quality problems from documentary deficits. So far, a comprehensive cost-utility analysis of cQA has not been provided, in particular with comparison to existing QA systems. In order to optimise cost and utility of cQA an evidence-based approach is required for both the extension of cQA areas and for QA provisions.

  15. Chiral symmetry aspects in the open charm sector

    NASA Astrophysics Data System (ADS)

    Buchheim, T.; Hilger, T.; Kämpfer, B.

    2016-01-01

    QCD sum rules serve as tools to investigate changing hadronic properties in a hot and/or dense nuclear medium. The role of chiral symmetry breaking and restoration effects in a medium can be addressed also in the heavy-light meson sector. Thus, we consider Weinberg sum rules which refer to chiral partner mesons composed of a light and a heavy quark.

  16. Staffing Practices in the Private Sector in Sri Lanka

    ERIC Educational Resources Information Center

    Wickramasinghe, Vathsala

    2007-01-01

    Purpose: This paper seeks to present and discuss the findings of a study of staffing practices in the Sri Lankan private sector with particular reference to junior level managerial jobs. The scope of staffing practices consisted of six major areas, namely the usage of information from job analysis in staffing, the sources of labour, selection…

  17. Corporate Governance: Can Universities Learn from the Private Sector?

    ERIC Educational Resources Information Center

    Henze, Raphaela

    2010-01-01

    Corporate governance has several objectives: growth, transparency, leadership, social responsibility and trust, as well as the protection of shareholders and company assets. It also plays a key role in determining a company's control environment. In this article, the author takes a closer look at corporate governance in the private sector,…

  18. Ionospheric Superstorms: Polarization Terminator Effects in the Atlantic Sector

    NASA Astrophysics Data System (ADS)

    Foster, J. C.; Erickson, P. J.

    2007-12-01

    A combination of the stormtime penetration electric fields, the effect of the reduced magnetic field strength in the South Atlantic magnetic anomaly, and the geographic distortion of the magnetic field in the Atlantic sector contribute to the characteristics of the low-latitude polarization electric fields at the sunset terminator. This combination of effects leads to a strong localized enhancement of TEC at low-mid latitudes in the American sector during ionospheric superstorms. At dusk, the low-latitude polarization electric field effects begin on magnetic field lines when the E region at either end goes into darkness. We define the polarization terminator (PT) to be the locus of points at a given altitude for which the E-region shadow height at either end of the magnetic field line equals 100 km. Electric fields associated with the charge build-up in the conductivity-gradient region due to the effects of winds or penetration electric fields are directed perpendicular to the PT and increase in magnitude as the PT is approached from the dayside. The particular configuration of the magnetic field in the Atlantic sector creates a preferred longitude/Universal Time sector (western atlantic/ 21 UT) for the build-up of enhanced TEC on field lines inside the dusk plasmapause. The electric fields associated with the PT sweep up the plasmas of the equatorial anomaly crests and redistribute it into the mid-latitude SAPS channels, forming the high total content storm enhanced density (SED) plumes observed during strong storms in the American sector. This effect is most pronounced for northern hemisphere summer conditions, as experienced during the July 15/16, 2000 superstorm.

  19. Ionospheric Superstorms: Polarization Terminator Effects in the Atlantic Sector

    NASA Astrophysics Data System (ADS)

    Foster, John

    A combination of the stormtime penetration electric fields, the effect of the reduced magnetic field strength in the South Atlantic magnetic anomaly, and the geographic distortion of the magnetic field in the Atlantic sector contribute to the characteristics of the low-latitude polarization electric fields at the sunset terminator. This combination of effects leads to a strong localized enhancement of TEC at low-mid latitudes in the American sector during ionospheric superstorms. At dusk, the low-latitude polarization electric field effects begin on magnetic field lines when the E region at either end goes into darkness. We define the polarization terminator (PT) to be the locus of points at a given altitude for which the E-region shadow height at either end of the magnetic field line equals 100 km. Electric fields associated with the charge build-up in the conductivity-gradient region due to the effects of winds or penetration electric fields are directed perpendicular to the PT and increase in magnitude as the PT is approached from the dayside. The particular configuration of the magnetic field in the Atlantic sector creates a preferred longitude/Universal Time sector (western Atlantic/ 21 UT) for the build-up of enhanced TEC on field lines inside the dusk plasmapause. The electric fields associated with the PT sweep up the plasmas of the equatorial anomaly crests and redistribute it into the mid-latitude SAPS channels, forming the high total content storm enhanced density (SED) plumes observed during strong storms in the American sector. This effect is most pronounced for northern hemisphere summer conditions, as experienced during the July 15/16, 2000 superstorm.

  20. Women Using Physics: Alternate Career Paths, The Private Sector

    NASA Astrophysics Data System (ADS)

    Tams, Jessica

    2006-12-01

    For those who have spent their careers inside the safe walls of academia, the word is a little scary. Can I compete? Will I fit in? What do I need to know? Am I prepared? Will I succeed? While many would say: Yes! You are ready to excel! This isn’t actually the case. The private sector comes with many unanticipated shocks to many of us, especially women. This isn’t a group project. This session will discuss entering a quickly growing and competitive technical field and what one can do to prepare for continued success. Preparing and Entering the Private Sector * Women with technical skills are a desired part of the private workforcein general women posses stronger people skills, are more reliable and often more well rounded than their male counterparts. Key factors we will discuss to landing that first job: · Expand your knowledge base with current applications of technology · Preparing a solid employment pitch to highlight strengths: Overcoming stereotypes · Don’t show them your bad side: Why some student projects may hurt you · The private sector attitude toward performance and entry level expectations Excelling in the Private Sector * Now that we have landed a job * for better or worse we are now all about making money and exerting control. What to keep in mind while working in the private sector: · The formative first years: focus on your weaknesses and practice, practice, practice · Men & Women in the workplace: what women subconsciously do to hurt their careers · Politics: Working in a team environment · Polish & Detail & Reliabilit