U.S. Population Data 1969-2016 - SEER Population Data

Cancer.gov

Download county population estimates used in SEER*Stat to calculate cancer incidence and mortality rates. The estimates are a modification of the U.S. Census Bureau's Population Estimates Program, in collaboration with National Center for Health Statistics.

Improved survival among older acute myeloid leukemia patients - a population-based study.

PubMed

Shah, Binay Kumar; Ghimire, Krishna Bilas

2014-07-01

Survival in acute myeloid leukemia (AML) has improved in younger patients over the last decade. This study was conducted to evaluate the relative survival rates in older AML patients over two decades in the US. We analyzed Surveillance, Epidemiology, and End Results (SEER) registry database to evaluate relative survival rate in older (≥ 75 years) AML population diagnosed during 1992-2009. We selected AML patients from 13 registries of SEER 18 database to compare RS during 1992-2000 and 2001-2009. The relative survival rates improved significantly during 2001-2009 compared to 1992-2000 for all age groups and sex. For young elderly patients (75-84 years) RS increased from 13.1 ± 0.8% to 17.4 ± 0.9% at one year Z-value = 3.98, p < 0.0001 and from 2.0 ± 0.4 to 2.6 ± 0.5%, Z-value = 3.61, p < 0.0005 at five years. Similarly, for very elderly (≥ 85 years) patients RS increased from 5.3 ± 1.0% to 8.0 ± 1.0%, Z-value = 3.03, p < 0.005 at one year, but no improvement seen at five years. The relative survival in elderly AML has increased significantly during 2001-2009 compared to 1992-2000.

Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries.

PubMed

Villano, J Lee; Propp, Jennifer M; Porter, Kimberly R; Stewart, Andrew K; Valyi-Nagy, Tibor; Li, Xinyu; Engelhard, Herbert H; McCarthy, Bridget J

2008-04-01

The exact incidence of pineal germ-cell tumors is largely unknown. The tumors are rare, and the number of patients with these tumors, as reported in clinical series, has been limited. The goal of this study was to describe pineal germ-cell tumors in a large number of patients, using data from available brain tumor databases. Three different databases were used: Surveillance, Epidemiology, and End Results (SEER) database (1973-2001); Central Brain Tumor Registry of the United States (CBTRUS; 1997-2001); and National Cancer Data Base (NCDB; 1985-2003). Tumors were identified using the International Classification of Diseases for Oncology, third edition (ICD-O-3), site code C75.3, and categorized according to histology codes 9060-9085. Data were analyzed using SAS/STAT release 8.2, SEER*Stat version 5.2, and SPSS version 13.0 software. A total of 1,467 cases of malignant pineal germ-cell tumors were identified: 1,159 from NCDB, 196 from SEER, and 112 from CBTRUS. All three databases showed a male predominance for pineal germ-cell tumors (>90%), and >72% of patients were Caucasian. The peak number of cases occurred in the 10- to 14-year age group in the CBTRUS data and in the 15- to 19-year age group in the SEER and NCDB data, and declined significantly thereafter. The majority of tumors (73%-86%) were germinomas, and patients with germinomas had the highest survival rate (>79% at 5 years). Most patients were treated with surgical resection and radiation therapy or with radiation therapy alone. The number of patients included in this study exceeds that of any study published to date. The proportions of malignant pineal germ-cell tumors and intracranial germ-cell tumors are in range with previous studies. Survival rates for malignant pineal germ-cell tumors are lower than results from recent treatment trials for intracranial germ-cell tumors, and patients that received radiation therapy in the treatment plan either with surgery or alone survived the longest.

Muddy Water? Variation in Reporting Receipt of Breast Cancer Radiation Therapy by Population-Based Tumor Registries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, Gary V.; Giordano, Sharon H.; Williams, Melanie

2013-07-15

Purpose: To evaluate, in the setting of breast cancer, the accuracy of registry radiation therapy (RT) coding compared with the gold standard of Medicare claims. Methods and Materials: Using Surveillance, Epidemiology, and End Results (SEER)–Medicare data, we identified 73,077 patients aged ≥66 years diagnosed with breast cancer in the period 2001-2007. Underascertainment (1 - sensitivity), sensitivity, specificity, κ, and χ{sup 2} were calculated for RT receipt determined by registry data versus claims. Multivariate logistic regression characterized patient, treatment, and geographic factors associated with underascertainment of RT. Findings in the SEER–Medicare registries were compared with three non-SEER registries (Florida, New York,more » and Texas). Results: In the SEER–Medicare registries, 41.6% (n=30,386) of patients received RT according to registry coding, versus 49.3% (n=36,047) according to Medicare claims (P<.001). Underascertainment of RT was more likely if patients resided in a newer SEER registry (odds ratio [OR] 1.70, 95% confidence interval [CI] 1.60-1.80; P<.001), rural county (OR 1.34, 95% CI 1.21-1.48; P<.001), or if RT was delayed (OR 1.006/day, 95% CI 1.006-1.007; P<.001). Underascertainment of RT receipt in SEER registries was 18.7% (95% CI 18.6-18.8%), compared with 44.3% (95% CI 44.0-44.5%) in non-SEER registries. Conclusions: Population-based tumor registries are highly variable in ascertainment of RT receipt and should be augmented with other data sources when evaluating quality of breast cancer care. Future work should identify opportunities for the radiation oncology community to partner with registries to improve accuracy of treatment data.« less

A new glacier inventory for 2009 reveals spatial and temporal variability in glacier response to atmospheric warming in the Northern Antarctic Peninsula, 1988-2009

NASA Astrophysics Data System (ADS)

Davies, B. J.; Carrivick, J. L.; Glasser, N. F.; Hambrey, M. J.; Smellie, J. L.

2011-12-01

The Northern Antarctic Peninsula has recently exhibited ice-shelf disintegration, glacier recession and acceleration. However, the dynamic response of land-terminating, ice-shelf tributary and tidewater glaciers has not yet been quantified or assessed for variability, and there are sparse published data for glacier classification, morphology, area, length or altitude. This paper firstly uses ASTER images from 2009 and a SPIRIT DEM from 2006 to classify the area, length, altitude, slope, aspect, geomorphology, type and hypsometry of 194 glaciers on Trinity Peninsula, Vega Island and James Ross Island. Secondly, this paper uses LANDSAT-4 and ASTER images from 1988 and 2001 and data from the Antarctic Digital Database (ADD) from 1997 to document glacier change 1988-2009. From 1988-2001, 90 % of glaciers receded, and from 2001-2009, 79 % receded. Glaciers on the western side of Trinity Peninsula retreated relatively little. On the eastern side of Trinity Peninsula, the rate of recession of ice-shelf tributary glaciers has slowed from 12.9 km2 a-1 (1988-2001) to 2.4 km2 a-1 (2001-2009). Tidewater glaciers on the drier, cooler Eastern Trinity Peninsula experienced fastest recession from 1988-2001, with limited frontal retreat after 2001. Land-terminating glaciers on James Ross Island also retreated fastest in the period 1988-2001. Large tidewater glaciers on James Ross Island are now declining in areal extent at rates of up to 0.04 km2 a-1. This east-west difference is largely a result of orographic temperature and precipitation gradients across the Antarctic Peninsula. Strong variability in tidewater glacier recession rates may result from the influence of glacier length, altitude, slope and hypsometry on glacier mass balance. High snowfall means that the glaciers on the Western Peninsula are not currently rapidly receding. Recession rates on the eastern side of Trinity Peninsula are slowing as the floating ice tongues retreat into the fjords and the glaciers reach a new dynamic equilibrium. The rapid glacier recession of tidewater glaciers on James Ross Island is likely to continue because of their low elevations and flat profiles. In contrast, the higher and steeper tidewater glaciers on the Eastern Antarctic Peninsula will attain more stable frontal positions after low-lying ablation areas are removed.

Development of National Program of Cancer Registries SAS Tool for Population-Based Cancer Relative Survival Analysis.

PubMed

Dong, Xing; Zhang, Kevin; Ren, Yuan; Wilson, Reda; O'Neil, Mary Elizabeth

2016-01-01

Studying population-based cancer survival by leveraging the high-quality cancer incidence data collected by the Centers for Disease Control and Prevention's National Program of Cancer Registries (NPCR) can offer valuable insight into the cancer burden and impact in the United States. We describe the development and validation of a SASmacro tool that calculates population-based cancer site-specific relative survival estimates comparable to those obtained through SEER*Stat. The NPCR relative survival analysis SAS tool (NPCR SAS tool) was developed based on the relative survival method and SAS macros developed by Paul Dickman. NPCR cancer incidence data from 25 states submitted in November 2012 were used, specifically cases diagnosed from 2003 to 2010 with follow-up through 2010. Decennial and annual complete life tables published by the National Center for Health Statistics (NCHS) for 2000 through 2009 were used. To assess comparability between the 2 tools, 5-year relative survival rates were calculated for 25 cancer sites by sex, race, and age group using the NPCR SAS tool and the National Cancer Institute's SEER*Stat 8.1.5 software. A module to create data files for SEER*Stat was also developed for the NPCR SAS tool. Comparison of the results produced by both SAS and SEER*Stat showed comparable and reliable relative survival estimates for NPCR data. For a majority of the sites, the net differences between the NPCR SAS tool and SEER*Stat-produced relative survival estimates ranged from -0.1% to 0.1%. The estimated standard errors were highly comparable between the 2 tools as well. The NPCR SAS tool will allow researchers to accurately estimate cancer 5-year relative survival estimates that are comparable to those produced by SEER*Stat for NPCR data. Comparison of output from the NPCR SAS tool and SEER*Stat provided additional quality control capabilities for evaluating data prior to producing NPCR relative survival estimates.

Impact of Extent of Surgery on Survival for Papillary Thyroid Cancer Patients Younger Than 45 Years

PubMed Central

Abdelgadir Adam, Mohamed; Pura, John; Goffredo, Paolo; Dinan, Michaela A.; Hyslop, Terry; Reed, Shelby D.; Scheri, Randall P.; Sosa, Julie A.

2015-01-01

Context: Papillary thyroid cancer (PTC) patients <45 years old are considered to have an excellent prognosis; however, current guidelines recommend total thyroidectomy for PTC tumors >1.0 cm, regardless of age. Objective: Our objective was to examine the impact of extent of surgery on overall survival (OS) in patients <45 years old with stage I PTC of 1.1 to 4.0 cm. Design, Setting, and Patients: Adult patients <45 years of age undergoing surgery for stage I PTC were identified from the National Cancer Data Base (NCDB, 1998–2006) and the Surveillance, Epidemiology, and End Results dataset (SEER, 1988–2006). Main Outcome Measure: Multivariable modeling was used to compare OS for patients undergoing total thyroidectomy vs lobectomy. Results: In total, 29 522 patients in NCDB (3151 lobectomy, 26 371 total thyroidectomy) and 13 510 in SEER (1379 lobectomy, 12 131 total thyroidectomy) were included. Compared with patients undergoing lobectomy, patients having total thyroidectomy more often had extrathyroidal and lymph node disease. At 14 years, unadjusted OS was equivalent between total thyroidectomy and lobectomy in both databases. After adjustment, OS was similar for total thyroidectomy compared with lobectomy across all patients with tumors of 1.1 to 4.0 cm (NCDB: hazard ratio = 1.45 [confidence interval = 0.88–2.51], P = 0.19; SEER: 0.95 (0.70–1.29), P = 0.75) and when stratified by tumor size: 1.1 to 2.0 cm (NCDB: 1.12 [0.50–2.51], P = 0.78; SEER: 0.95 [0.56–1.62], P = 0.86) and 2.1 to 4.0 cm (NCDB: 1.93 [0.88–4.23], P = 0.10; SEER: 0.94 [0.60–1.49], P = 0.80). Conclusions: After adjusting for patient and clinical characteristics, total thyroidectomy compared with thyroid lobectomy was not associated with improved survival for patients <45 years of age with stage I PTC of 1.1 to 4.0 cm. Additional clinical and pathologic factors should be considered when choosing extent of resection. PMID:25337927

A Low-Maintenance Approach to Improving Retention: Short On-Line Tutorials in Elementary Statistics

ERIC Educational Resources Information Center

Sargent, Carol Springer; Borthick, A. Faye; Lederberg, Amy R.; Haardorfer, Regine

2013-01-01

The struggle to get weak students to use learning support services plagues virtually all retention programs (Friedlander, 1980; Hodges, 2001; Karabenick & Knapp, 1988; Moore & LeDee, 2006; Simpson, Hynd, Nist, & Burrell, 1997; Webster & Dee, 1998). This study presents a cost-effective form of supplemental instruction (SI), in the form of on-line…

Regeneration and survival of whitebark pine after the 1988 Yellowstone fires

Treesearch

Diana F. Tomback; Anna W. Schoettle; Mario J. Perez; Kristen M. Grompone; Sabine Mellmann-Brown

2011-01-01

Successional whitebark pine (Pinus albicaulis) communities are dependent on fire and other disturbances for renewal (Arno 2001). Where whitebark pine regenerates results from cache site selection by Clark's nutcrackers (Nucifraga columbiana) in relation to the environmental tolerances of seeds and seedlings (Tomback 2001). After the 1988 Yellowstone fires, we...

Racial differences in colorectal cancer survival in the Detroit Metropolitan Area.

PubMed

Yan, Ben; Noone, Anne-Michelle; Yee, Cecilia; Banerjee, Mousumi; Schwartz, Kendra; Simon, Michael S

2009-08-15

Colorectal carcinoma is the second most common cause of cancer death with African Americans having lower survival compared with White Americans. The purpose of this study was to investigate the effect of demographics, clinical factors, and socioeconomic status (SES) on racial disparities in colorectal cancer survival in the Detroit Metropolitan Area. The study population included 9078 individuals with primary invasive colorectal cancer identified between 1988 and 1992 through the Surveillance, Epidemiology, and End Results (SEER) program. Demographics, clinical information, and survival were obtained through SEER. SES was categorized using occupation, educational level, and poverty status at the census tract level. Kaplan-Meier survival curves and Cox proportional hazards regression were used to compare overall survival by race. African Americans were more likely to be diagnosed with stage IV disease (P < .001), and to reside within poor census tracts (P < .001) compared with White Americans. Unadjusted analysis showed that African Americans had a significantly higher risk of death compared with their White American counterparts (hazards ratio [HR], 1.13; 95% confidence interval [CI], 1.07-1.20). After adjusting for age, marital status, sex, SES group, TNM stage, and treatment, race was no longer significantly associated with overall survival (HR, 1.00; 95% CI, 0.92-1.09). Similar results were seen with colorectal cancer-specific survival. Racial disparities in colorectal cancer survival dissipate after adjusting for other demographic and clinical factors. These results can potentially affect medical guidelines regarding screening and treatment, and possibly influence public health policies that can have a positive impact on equalizing racial differences in access to care.

Specific-conductance, water-temperature, and water-level data, San Francisco Bay, California, for water years 2001-2002

USGS Publications Warehouse

Buchanan, P.A.

2003-01-01

This article presents time-series plots of specific-conductance, water-temperature, and water-level data collected in San Francisco Bay during water years 2001 and 2002 (October 1, 2000, through September 30, 2002). Specific-conductance and water-temperature data were recorded at 15-minute intervals at the following US Geological Survey (USGS) locations (Figure 1): • Suisun Bay at Benicia Bridge, near Benicia, California (BEN) (site # 11455780) • Carquinez Strait at Carquinez Bridge, near Crockett, California (CARQ) (site # 11455820) • Napa River at Mare Island Causeway, near Vallejo, California (NAP) (site # 11458370) • San Pablo Strait at Point San Pablo, California (PSP) (site # 11181360) • San Pablo Bay at Petaluma River Channel Marker 9, California (SPB) (site # 380519122262901) • San Francisco Bay at Presidio Military Reservation, California (PRES) (site # 11162690) • San Francisco Bay at Pier 24, at San Francisco, California (P24) (site # 11162700) • San Francisco Bay at San Mateo Bridge, near Foster City, California (SMB) (site # 11162765). Water-level data were recorded only at PSP through January 1, 2001. Suspended-sediment concentration data also were collected at most of these sites and were published by Buchanan and Ganju (2003). The data from PSP, PRES, P24, and SMB were recorded by the California Department of Water Resources (DWR) before 1988, by the USGS National Research Program from 1988 to 1989, and by the USGSDWR cooperative program since 1990. BEN, CARQ, NAP, and SPB were established in 1998 by the USGS.

Avifaunal responses to fire in southwestern montane forests along a burn severity gradient

Treesearch

Natasha B. Kotliar; Patricia L. Kennedy; Kimberly Ferree

2007-01-01

The effects of burn severity on avian communities are poorly understood, yet this information is crucial to fire management programs. To quantify avian response patterns along a burn severity gradient, we sampled 49 random plots (2001-2002) at the 17351-ha Cerro Grande Fire (2000) in New Mexico, USA. Additionally, pre-fire avian surveys (1986- 1988, 1990) created a...

Variable glacier response to atmospheric warming, northern Antarctic Peninsula, 1988-2009

NASA Astrophysics Data System (ADS)

Davies, B. J.; Carrivick, J. L.; Glasser, N. F.; Hambrey, M. J.; Smellie, J. L.

2012-09-01

The northern Antarctic Peninsula has recently exhibited ice-shelf disintegration, glacier recession and acceleration. However, the dynamic response of land-terminating, ice-shelf tributary and tidewater glaciers has not yet been quantified or assessed for variability, and there are sparse data for glacier classification, morphology, area, length or altitude. This paper firstly classifies the area, length, altitude, slope, aspect, geomorphology, type and hypsometry of 194 glaciers on Trinity Peninsula, Vega Island and James Ross Island in 2009 AD. Secondly, this paper documents glacier change 1988-2009. In 2009, the glacierised area was 8140±262 km2. From 1988-2001, 90% of glaciers receded, and from 2001-2009, 79% receded. This equates to an area change of -4.4% for Trinity Peninsula eastern coast glaciers, -0.6% for western coast glaciers, and -35.0% for ice-shelf tributary glaciers from 1988-2001. Tidewater glaciers on the drier, cooler eastern Trinity Peninsula experienced fastest shrinkage from 1988-2001, with limited frontal change after 2001. Glaciers on the western Trinity Peninsula shrank less than those on the east. Land-terminating glaciers on James Ross Island shrank fastest in the period 1988-2001. This east-west difference is largely a result of orographic temperature and precipitation gradients across the Antarctic Peninsula, with warming temperatures affecting the precipitation-starved glaciers on the eastern coast more than on the western coast. Reduced shrinkage on the western Peninsula may be a result of higher snowfall, perhaps in conjunction with the fact that these glaciers are mostly grounded. Rates of area loss on the eastern side of Trinity Peninsula are slowing, which we attribute to the floating ice tongues receding into the fjords and reaching a new dynamic equilibrium. The rapid shrinkage of tidewater glaciers on James Ross Island is likely to continue because of their low elevations and flat profiles. In contrast, the higher and steeper tidewater glaciers on the eastern Antarctic Peninsula will attain more stable frontal positions after low-lying ablation areas are removed, reaching equilibrium more quickly.

47 CFR 1.2001 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 1 2011-10-01 2011-10-01 false Purpose. 1.2001 Section 1.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Implementation of the Anti-Drug Abuse Act of 1988 § 1.2001 Purpose. To determine eligibility for professional and/or commercial licenses...

47 CFR 1.2001 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Purpose. 1.2001 Section 1.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Implementation of the Anti-Drug Abuse Act of 1988 § 1.2001 Purpose. To determine eligibility for professional and/or commercial licenses...

Trends in the Utilization of Brachytherapy in Cervical Cancer in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Han, Kathy, E-mail: Kathy.Han@rmp.uhn.on.ca; Milosevic, Michael; Fyles, Anthony

2013-09-01

Purpose: To determine the trends in brachytherapy use in cervical cancer in the United States and to identify factors and survival benefits associated with brachytherapy treatment. Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 7359 patients with stages IB2-IVA cervical cancer treated with external beam radiation therapy (EBRT) between 1988 and 2009. Propensity score matching was used to adjust for differences between patients who received brachytherapy and those who did not from 2000 onward (after the National Cancer Institute alert recommending concurrent chemotherapy). Results: Sixty-three percent of the 7359 women received brachytherapy in combinationmore » with EBRT, and 37% received EBRT alone. The brachytherapy utilization rate has decreased from 83% in 1988 to 58% in 2009 (P<.001), with a sharp decline of 23% in 2003 to 43%. Factors associated with higher odds of brachytherapy use include younger age, married (vs single) patients, earlier years of diagnosis, earlier stage and certain SEER regions. In the propensity score-matched cohort, brachytherapy treatment was associated with higher 4-year cause-specific survival (CSS; 64.3% vs 51.5%, P<.001) and overall survival (OS; 58.2% vs 46.2%, P<.001). Brachytherapy treatment was independently associated with better CSS (hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.57-0.71), and OS (HR 0.66; 95% CI, 0.60 to 0.74). Conclusions: This population-based analysis reveals a concerning decline in brachytherapy utilization and significant geographic disparities in the delivery of brachytherapy in the United States. Brachytherapy use is independently associated with significantly higher CSS and OS and should be implemented in all feasible cases.« less

U.S. Datasets

Cancer.gov

Datasets for U.S. mortality, U.S. populations, standard populations, county attributes, and expected survival. Plus SEER-linked databases (SEER-Medicare, SEER-Medicare Health Outcomes Survey [SEER-MHOS], SEER-Consumer Assessment of Healthcare Providers and Systems [SEER-CAHPS]).

Is Mammography Useful in Older Women

DTIC Science & Technology

1999-06-01

mammography in women age 70 and older . Using the Linked Medicare-SEER Tumor Registry Database, created by the National Cancer Institute and the Health Care... Health Interview Survey) have documented that mammography use decreases with advancing age (11,21,22). In 1993, only 25% of women age 65 and older ...related health services research. The linked database contains cancer information on patients 65 years of age and older from NCI’s SEER Program and

47 CFR 1.2001 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 1 2014-10-01 2014-10-01 false Purpose. 1.2001 Section 1.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Implementation of the Anti-Drug Abuse Act of 1988 § 1.2001 Purpose. To determine eligibility for professional and...

47 CFR 1.2001 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 1 2013-10-01 2013-10-01 false Purpose. 1.2001 Section 1.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Implementation of the Anti-Drug Abuse Act of 1988 § 1.2001 Purpose. To determine eligibility for professional and...

47 CFR 1.2001 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 1 2012-10-01 2012-10-01 false Purpose. 1.2001 Section 1.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Implementation of the Anti-Drug Abuse Act of 1988 § 1.2001 Purpose. To determine eligibility for professional and...

Prognostic value of site-specific extra-hepatic disease in hepatocellular carcinoma: a SEER database analysis.

PubMed

Oweira, Hani; Petrausch, Ulf; Helbling, Daniel; Schmidt, Jan; Mehrabi, Arianeb; Schöb, Othmar; Giryes, Anwar; Abdel-Rahman, Omar

2017-07-01

We the prognostic value of site-specific extra-hepatic disease in hepatocellular carcinoma (HCC) patients registered within the surveillance, epidemiology and end results (SEER) database. SEER database (2010-2013) has been queried through SEER*Stat program to determine the prognosis of advanced HCC patients according to the site of extra-hepatic disease. Survival analysis has been conducted through Kaplan Meier analysis. A total of 4396 patients with stage IV HCC were identified in the period from 2010-2013 and they were included into this analysis. Patients with isolated regional lymph node involvement have better outcomes compared to patients with any other site of extra-hepatic disease (P < 0.0001 for both endpoints). Among patients with distant metastases, patients with bone metastases have better outcomes compared to patients with lung metastases (P < 0.0001 for both endpoints). Multivariate analysis revealed that younger age, normal alpha fetoprotein, single site of extra-hepatic disease, local treatment to the primary tumor and surgery to the metastatic disease were associated with better overall survival and liver cancer-specific survival. Within the limits of the current SEER analysis, HCC patients with isolated lung metastases seem to have worse outcomes compared to patients with isolated bone or regional nodal metastases.​.

Ask a SEER Registrar - SEER Registrars

Cancer.gov

First submit questions to your central registry as required and they will submit them to SEER. Use the form on this page to submit questions to SEER staff about coding cancer cases or SEER's reporting guideline materials. Coding and abstracting answers are on SEER Inquiry System website.

Comparing trends in cancer rates across overlapping regions.

PubMed

Li, Yi; Tiwari, Ram C

2008-12-01

Monitoring and comparing trends in cancer rates across geographic regions or over different time periods have been major tasks of the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) Program as it profiles healthcare quality as well as decides healthcare resource allocations within a spatial-temporal framework. A fundamental difficulty, however, arises when such comparisons have to be made for regions or time intervals that overlap, for example, comparing the change in trends of mortality rates in a local area (e.g., the mortality rate of breast cancer in California) with a more global level (i.e., the national mortality rate of breast cancer). In view of sparsity of available methodologies, this article develops a simple corrected Z-test that accounts for such overlapping. The performance of the proposed test over the two-sample "pooled"t-test that assumes independence across comparison groups is assessed via the Pitman asymptotic relative efficiency as well as Monte Carlo simulations and applications to the SEER cancer data. The proposed test will be important for the SEER * STAT software, maintained by the NCI, for the analysis of the SEER data.

Characterization of Fouling at Field Test Sites of the ONR Biofouling Program: Background Information and Results for 2006-2007

DTIC Science & Technology

2008-10-01

Crassostrea virginica, and Hydroides dianthus to fouling-release coatings. Biofouling 17:155-167. Meyer AE, Baier RE, King RW. 1988. Initial fouling...Truby K, Darkangelo Wood C. 2001. Variation in adhesion strength of Balanus eburneus, Crassostrea virginica, and Hydroides dianthus to fouling...strength of Balanus eburneus, Crassostrea virginica, and Hydroides dianthus to fouling-release coatings. Biofouling 17:155-167. Mook D. 1976. Studies of

A National-Level Validation of the New American Joint Committee on Cancer 8th Edition Subclassification of Stage IIA and B Anal Squamous Cell Cancer.

PubMed

Goffredo, Paolo; Garancini, Mattia; Robinson, Timothy J; Frakes, Jessica; Hoshi, Hisakazu; Hassan, Imran

2018-06-01

The 8th edition of the American Joint Committee on Cancer (AJCC) updated the staging system of anal squamous cell cancer (ASCC) by subdividing stage II into A (T2N0M0) and B (T3N0M0) based on a secondary analysis of the RTOG 98-11 trial. We aimed to validate this new subclassification utilizing two nationally representative databases. The National Cancer Database (NCDB) [2004-2014] and the Surveillance, Epidemiology, and End Results (SEER) database [1988-2013] were queried to identify patients with stage II ASCC. A total of 6651 and 2579 stage IIA (2-5 cm) and 1777 and 641 stage IIB (> 5 cm) patients were identified in the NCDB and SEER databases, respectively. Compared with stage IIB patients, stage IIA patients within the NCDB were more often females with fewer comorbidities. No significant differences were observed between age, race, receipt of chemotherapy and radiation, and mean radiation dose. Demographic, clinical, and pathologic characteristics were comparable between patients in both datasets. The 5-year OS was 72% and 69% for stage IIA versus 57% and 50% for stage IIB in the NCDB and SEER databases, respectively (p < 0.001). After adjustment for available demographic and clinical confounders, stage IIB was significantly associated with worse survival in both cohorts (hazard ratio 1.58 and 2.01, both p < 0.001). This study validates the new AJCC subclassification of stage II anal cancer into A and B based on size (2-5 cm vs. > 5 cm) in the general ASCC population. AJCC stage IIB patients represent a higher risk category that should be targeted with more aggressive/novel therapies.

SEER Linked Databases - SEER Datasets

Cancer.gov

SEER-Medicare database of elderly persons with cancer is useful for epidemiologic and health services research. SEER-MHOS has health-related quality of life information about elderly persons with cancer. SEER-CAHPS database has clinical, survey, and health services information on people with cancer.

Validation of prostate-specific antigen laboratory values recorded in Surveillance, Epidemiology, and End Results registries.

PubMed

Adamo, Margaret Peggy; Boten, Jessica A; Coyle, Linda M; Cronin, Kathleen A; Lam, Clara J K; Negoita, Serban; Penberthy, Lynne; Stevens, Jennifer L; Ward, Kevin C

2017-02-15

Researchers have used prostate-specific antigen (PSA) values collected by central cancer registries to evaluate tumors for potential aggressive clinical disease. An independent study collecting PSA values suggested a high error rate (18%) related to implied decimal points. To evaluate the error rate in the Surveillance, Epidemiology, and End Results (SEER) program, a comprehensive review of PSA values recorded across all SEER registries was performed. Consolidated PSA values for eligible prostate cancer cases in SEER registries were reviewed and compared with text documentation from abstracted records. Four types of classification errors were identified: implied decimal point errors, abstraction or coding implementation errors, nonsignificant errors, and changes related to "unknown" values. A total of 50,277 prostate cancer cases diagnosed in 2012 were reviewed. Approximately 94.15% of cases did not have meaningful changes (85.85% correct, 5.58% with a nonsignificant change of <1 ng/mL, and 2.80% with no clinical change). Approximately 5.70% of cases had meaningful changes (1.93% due to implied decimal point errors, 1.54% due to abstract or coding errors, and 2.23% due to errors related to unknown categories). Only 419 of the original 50,277 cases (0.83%) resulted in a change in disease stage due to a corrected PSA value. The implied decimal error rate was only 1.93% of all cases in the current validation study, with a meaningful error rate of 5.81%. The reasons for the lower error rate in SEER are likely due to ongoing and rigorous quality control and visual editing processes by the central registries. The SEER program currently is reviewing and correcting PSA values back to 2004 and will re-release these data in the public use research file. Cancer 2017;123:697-703. © 2016 American Cancer Society. © 2016 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.

SEER*Educate: Use of Abstracting Quality Index Scores to Monitor Improvement of All Employees.

PubMed

Potts, Mary S; Scott, Tim; Hafterson, Jennifer L

2016-01-01

Integral parts of the Seattle-Puget Sound's Cancer Surveillance System registry's continuous improvement model include the incorporation of SEER*Educate into its training program for all staff and analyzing assessment results using the Abstracting Quality Index (AQI). The AQI offers a comprehensive measure of overall performance in SEER*Educate, which is a Web-based application used to personalize learning and diagnostically pinpoint each staff member's place on the AQI continuum. The assessment results are tallied from 6 abstracting standards within 2 domains: incidence reporting and coding accuracy. More than 100 data items are aligned to 1 or more of the 6 standards to build an aggregated score that is placed on a continuum for continuous improvement. The AQI score accurately identifies those individuals who have a good understanding of how to apply the 6 abstracting standards to reliably generate high quality abstracts.

The effect of multiple primary rules on population-based cancer survival

PubMed Central

Weir, Hannah K.; Johnson, Christopher J.; Thompson, Trevor D.

2015-01-01

Purpose Different rules for registering multiple primary (MP) cancers are used by cancer registries throughout the world, making international data comparisons difficult. This study evaluates the effect of Surveillance, Epidemiology, and End Results (SEER) and International Association of Cancer Registries (IACR) MP rules on population-based cancer survival estimates. Methods Data from five US states and six metropolitan area cancer registries participating in the SEER Program were used to estimate age-standardized relative survival (RS%) for first cancers-only and all first cancers matching the selection criteria according to SEER and IACR MP rules for all cancer sites combined and for the top 25 cancer site groups among men and women. Results During 1995–2008, the percentage of MP cancers (all sites, both sexes) increased 25.4 % by using SEER rules (from 14.6 to 18.4 %) and 20.1 % by using IACR rules (from 13.2 to 15.8 %). More MP cancers were registered among females than among males, and SEER rules registered more MP cancers than IACR rules (15.8 vs. 14.4 % among males; 17.2 vs. 14.5 % among females). The top 3 cancer sites with the largest differences were melanoma (5.8 %), urinary bladder (3.5 %), and kidney and renal pelvis (2.9 %) among males, and breast (5.9 %), melanoma (3.9 %), and urinary bladder (3.4 %) among females. Five-year survival estimates (all sites combined) restricted to first primary cancers-only were higher than estimates by using first site-specific primaries (SEER or IACR rules), and for 11 of 21 sites among males and 11 of 23 sites among females. SEER estimates are comparable to IACR estimates for all site-specific cancers and marginally higher for all sites combined among females (RS 62.28 vs. 61.96 %). Conclusion Survival after diagnosis has improved for many leading cancers. However, cancer patients remain at risk of subsequent cancers. Survival estimates based on first cancers-only exclude a large and increasing number of MP cancers. To produce clinically and epidemiologically relevant and less biased cancer survival estimates, data on all cancers should be included in the analysis. The multiple primary rules (SEER or IACR) used to identify primary cancers do not affect survival estimates if all first cancers matching the selection criteria are used to produce site-specific survival estimates. PMID:23558444

Thyroid cancer incidence patterns in Sao Paulo, Brazil, and the U.S. SEER program, 1997-2008.

PubMed

Veiga, Lene H S; Neta, Gila; Aschebrook-Kilfoy, Briseis; Ron, Elaine; Devesa, Susan S

2013-06-01

Thyroid cancer incidence has risen steadily over the last few decades in most of the developed world, but information on incidence trends in developing countries is limited. Sao Paulo, Brazil, has one of the highest rates of thyroid cancer worldwide, higher than in the United States. We examined thyroid cancer incidence patterns using data from the Sao Paulo Cancer Registry (SPCR) in Brazil and the National Cancer Institute's Surveillance Epidemiology End Results (SEER) program in the United States. Data on thyroid cancer cases diagnosed during 1997-2008 were obtained from SPCR (n=15,892) and SEER (n=42,717). Age-adjusted and age-specific rates were calculated by sex and histology and temporal patterns were compared between the two populations. Overall incidence rates increased over time in both populations and were higher in Sao Paulo than in the United States among females (SPCR/SEER incidence rate ratio [IRR]=1.65) and males (IRR=1.23). Papillary was the most common histology in both populations, followed by follicular and medullary carcinomas. Incidence rates by histology were consistently higher in Sao Paulo than in the United States, with the greatest differences for follicular (IRR=2.44) and medullary (IRR=3.29) carcinomas among females. The overall female/male IRR was higher in Sao Paulo (IRR=4.17) than in SEER (IRR=3.10) and did not change over time. Papillary rates rose over time more rapidly in Sao Paulo (annual percentage change=10.3% among females and 9.6% among males) than in the United States (6.9% and 5.7%, respectively). Regardless of sex, rates rose faster among younger people (<50 years) in Sao Paulo, but among older people (≥50 years) in the United States. The papillary to follicular carcinoma ratio rose from <3 to >8 among both Sao Paulo males and females, in contrast to increases from 9 to 12 and from 6 to 7 among U.S.males and females, respectively. Increased diagnostic activity may be contributing to the notable rise in incidence, mainly for papillary type, in both populations, but it is not likely to be the only reason. Differences in iodine nutrition status between Sao Paulo and the U.S. SEER population might have affected the observed incidence patterns.

Thyroid Cancer Incidence Patterns in Sao Paulo, Brazil, and the U.S. SEER Program, 1997–2008

PubMed Central

Neta, Gila; Aschebrook-Kilfoy, Briseis; Ron, Elaine; Devesa, Susan S.

2013-01-01

Background Thyroid cancer incidence has risen steadily over the last few decades in most of the developed world, but information on incidence trends in developing countries is limited. Sao Paulo, Brazil, has one of the highest rates of thyroid cancer worldwide, higher than in the United States. We examined thyroid cancer incidence patterns using data from the Sao Paulo Cancer Registry (SPCR) in Brazil and the National Cancer Institute's Surveillance Epidemiology End Results (SEER) program in the United States. Methods Data on thyroid cancer cases diagnosed during 1997–2008 were obtained from SPCR (n=15,892) and SEER (n=42,717). Age-adjusted and age-specific rates were calculated by sex and histology and temporal patterns were compared between the two populations. Results Overall incidence rates increased over time in both populations and were higher in Sao Paulo than in the United States among females (SPCR/SEER incidence rate ratio [IRR]=1.65) and males (IRR=1.23). Papillary was the most common histology in both populations, followed by follicular and medullary carcinomas. Incidence rates by histology were consistently higher in Sao Paulo than in the United States, with the greatest differences for follicular (IRR=2.44) and medullary (IRR=3.29) carcinomas among females. The overall female/male IRR was higher in Sao Paulo (IRR=4.17) than in SEER (IRR=3.10) and did not change over time. Papillary rates rose over time more rapidly in Sao Paulo (annual percentage change=10.3% among females and 9.6% among males) than in the United States (6.9% and 5.7%, respectively). Regardless of sex, rates rose faster among younger people (<50 years) in Sao Paulo, but among older people (≥50 years) in the United States. The papillary to follicular carcinoma ratio rose from <3 to >8 among both Sao Paulo males and females, in contrast to increases from 9 to 12 and from 6 to 7 among U.S.males and females, respectively. Conclusions Increased diagnostic activity may be contributing to the notable rise in incidence, mainly for papillary type, in both populations, but it is not likely to be the only reason. Differences in iodine nutrition status between Sao Paulo and the U.S. SEER population might have affected the observed incidence patterns. PMID:23410185

SEER Bibliography

Cancer.gov

Search this database of articles and other publications produced by cancer registry staff and Surveillance Research Program staff. Search by author, title, date, and organization. Provides links to PubMed and abstracts.

SEER*Stat Software

Cancer.gov

If you have access to SEER Research Data, use SEER*Stat to analyze SEER and other cancer-related databases. View individual records and produce statistics including incidence, mortality, survival, prevalence, and multiple primary. Tutorials and related analytic software tools are available.

Prognostic factors for survival in patients with Ewing's sarcoma using the surveillance, epidemiology, and end results (SEER) program database.

PubMed

Duchman, Kyle R; Gao, Yubo; Miller, Benjamin J

2015-04-01

The current study aims to determine cause-specific survival in patients with Ewing's sarcoma while reporting clinical risk factors for survival. The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify patients with osseous Ewing's sarcoma from 1991 to 2010. Patient, tumor, and socioeconomic variables were analyzed to determine prognostic factors for survival. There were 1163 patients with Ewing's sarcoma identified in the SEER Program database. The 10-year cause-specific survival for patients with non-metastatic disease at diagnosis was 66.8% and 28.1% for patients with metastatic disease. Black patients demonstrated reduced survival at 10 years with an increased frequency of metastatic disease at diagnosis as compared to patients of other race, while Hispanic patients more frequently presented with tumor size>10cm. Univariate analysis revealed that metastatic disease at presentation, tumor size>10cm, axial tumor location, patient age≥20 years, black race, and male sex were associated with decreased cause-specific survival at 10 years. Metastatic disease at presentation, axial tumor location, tumor size>10cm, and age≥20 years remained significant in the multivariate analysis. Patients with Ewing's sarcoma have decreased cause-specific survival at 10 years when metastatic at presentation, axial tumor location, tumor size>10cm, and patient age≥20 years. Copyright © 2015 Elsevier Ltd. All rights reserved.

Modeling Dislocations and Disclinations with Finite Micropolar Elastoplasticity

DTIC Science & Technology

2006-02-01

substructures on flow stress ( Mughrabi , 1983, 1988, 2001; Berveiller et al ., 1993; Zaiser, 1998). Meyers and co-workers (Meyers and Ashworth, 1982... al . / International Journal of Plasticity 22 (2006) 210–256 211order gradients of elastic or plastic parts of the total deformation gradient may alone...polycrystals (Hughes et al ., 1997, 2003; Kuhl- mann-Wilsdorf, 1999; Butler et al ., 2000; Barton and Dawson, 2001; Hughes, 2001; Leffers, 2001). Also measured

The effect of multiple primary rules on cancer incidence rates and trends

PubMed Central

Weir, Hannah K.; Johnson, Christopher J.; Ward, Kevin C.; Coleman, Michel P.

2018-01-01

Purpose An examination of multiple primary cancers can provide insight into the etiologic role of genes, the environment, and prior cancer treatment on a cancer patient’s risk of developing a subsequent cancer. Different rules for registering multiple primary cancers (MP) are used by cancer registries throughout the world making data comparisons difficult. Methods We evaluated the effect of SEER and IARC/IACR rules on cancer incidence rates and trends using data from the SEER Program. We estimated age-standardized incidence rate (ASIR) and trends (1975–2011) for the top 26 cancer categories using joinpoint regression analysis. Results ASIRs were higher using SEER compared to IARC/IACR rules for all cancers combined (3 %) and, in rank order, melanoma (9 %), female breast (7 %), urinary bladder (6 %), colon (4 %), kidney and renal pelvis (4 %), oral cavity and pharynx (3 %), lung and bronchus (2 %), and non-Hodgkin lymphoma (2 %). ASIR differences were largest for patients aged 65+ years. Trends were similar using both MP rules with the exception of cancers of the urinary bladder, and kidney and renal pelvis. Conclusions The choice of multiple primary coding rules effects incidence rates and trends. Compared to SEER MP coding rules, IARC/IACR rules are less complex, have not changed over time, and report fewer multiple primary cancers, particularly cancers that occur in paired organs, at the same anatomic site and with the same or related histologic type. Cancer registries collecting incidence data using SEER rules may want to consider including incidence rates and trends using IARC/IACR rules to facilitate international data comparisons. PMID:26809509

Survival trends among patients with advanced renal cell carcinoma in the United States.

PubMed

Shah, Binay Kumar; Ghimire, Krishna Bilas

2015-01-01

Since the approval of sorafenib in December 2005, several targeted therapeutic agents have been approved by the FDA for the treatment of advanced renal cell carcinoma (RCC). This study was conducted to find out whether the improvements in survival of advanced RCC patients with targeted agents have translated into a survival benefit in a population-based cohort. We analyzed the SEER 18 (Surveillance, Epidemiology and End RESULTS) registry database to calculate the relative survival rates for advanced RCC patients during 2001-2009, 2001-2005, 2006-2007 and 2008-2009. We also evaluated the survival rates by age (<65 and ≥65 years) and sex. The total number of advanced RCC patients during 2001-2009, 2001-2005, 2006-2007 and 2008-2009 were 7,047, 4,059, 1,548 and 1,440, respectively. During 2001-2009, the 1- and 3-year relative survival rates were 26.7±0.6 and 10.0±0.4%, respectively. There was no significant difference in 1-year relative survival rates for patients diagnosed during 2006-2007 and 2008-2009 compared to those diagnosed during 2001-2005. Similarly, the 3-year survival rates for patients diagnosed during 2006-2007 were similar to those diagnosed during 2001-2005. This population-based study showed that there was no significant improvement in relative survival rates among advanced RCC patients in the era of targeted agents. © 2014 S. Karger AG, Basel.

Mortality and survival patterns of childhood lymphomas: geographic and age-specific patterns in Southern-Eastern European and SEER/US registration data.

PubMed

Karalexi, Maria A; Georgakis, Marios K; Dessypris, Nick; Ryzhov, Anton; Zborovskaya, Anna; Dimitrova, Nadya; Zivkovic, Snezana; Eser, Sultan; Antunes, Luis; Sekerija, Mario; Zagar, Tina; Bastos, Joana; Demetriou, Anna; Agius, Domenic; Florea, Margareta; Coza, Daniela; Bouka, Evdoxia; Dana, Helen; Hatzipantelis, Emmanuel; Kourti, Maria; Moschovi, Maria; Polychronopoulou, Sophia; Stiakaki, Eftichia; Pourtsidis, Apostolos; Petridou, Eleni Th

2017-12-01

Childhood (0-14 years) lymphomas, nowadays, present a highly curable malignancy compared with other types of cancer. We used readily available cancer registration data to assess mortality and survival disparities among children residing in Southern-Eastern European (SEE) countries and those in the United States. Average age-standardized mortality rates and time trends of Hodgkin (HL) and non-Hodgkin (NHL; including Burkitt [BL]) lymphomas in 14 SEE cancer registries (1990-2014) and the Surveillance, Epidemiology, and End Results Program (SEER, United States; 1990-2012) were calculated. Survival patterns in a total of 8918 cases distinguishing also BL were assessed through Kaplan-Meier curves and multivariate Cox regression models. Variable, rather decreasing, mortality trends were noted among SEE. Rates were overall higher than that in SEER (1.02/10 6 ), which presented a sizeable (-4.8%, P = .0001) annual change. Additionally, remarkable survival improvements were manifested in SEER (10 years: 96%, 86%, and 90% for HL, NHL, and BL, respectively), whereas diverse, still lower, rates were noted in SEE. Non-HL was associated with a poorer outcome and an amphi-directional age-specific pattern; specifically, prognosis was inferior in children younger than 5 years than in those who are 10 to 14 years old from SEE (hazard ratio 1.58, 95% confidence interval 1.28-1.96) and superior in children who are 5 to 9 years old from SEER/United States (hazard ratio 0.63, 95% confidence interval 0.46-0.88) than in those who are 10 to 14 years old. In conclusion, higher SEE lymphoma mortality rates than those in SEER, but overall decreasing trends, were found. Despite significant survival gains among developed countries, there are still substantial geographic, disease subtype-specific, and age-specific outcome disparities pointing to persisting gaps in the implementation of new treatment modalities and indicating further research needs. Copyright © 2016 John Wiley & Sons, Ltd.

Probability estimates for the unique childhood leukemia cluster in Fallon, Nevada, and risks near other U.S. Military aviation facilities.

PubMed Central

Steinmaus, Craig; Lu, Meng; Todd, Randall L; Smith, Allan H

2004-01-01

A unique cluster of childhood leukemia has recently occurred around the city of Fallon in Churchill County, Nevada. From 1999 to 2001, 11 cases were diagnosed in this county of 23,982 people. Exposures related to a nearby naval air station such as jet fuel or an infectious agent carried by naval aviators have been hypothesized as potential causes. The possibility that the cluster could be attributed to chance was also considered. We used data from the Surveillance, Epidemiology, and End Results Program (SEER) to examine the likelihood that chance could explain this cluster. We also used SEER and California Cancer Registry data to evaluate rates of childhood leukemia in other U.S. counties with military aviation facilities. The age-standardized rate ratio (RR) in Churchill County was 12.0 [95% confidence interval (CI), 6.0-21.4; p = 4.3 times symbol 10(-9)]. A cluster of this magnitude would be expected to occur in the United States by chance about once every 22,000 years. The age-standardized RR for the five cases diagnosed after the cluster was first reported was 11.2 (95% CI, 3.6-26.3). In contrast, the incidence rate was not increased in all other U.S. counties with military aviation bases (RR = 1.04; 95% CI, 0.97-1.12) or in the subset of rural counties with military aviation bases (RR = 0.72; 95% CI, 0.48-1.08). These findings suggest that the Churchill County cluster was unlikely due to chance, but no general increase in childhood leukemia was found in other U.S. counties with military aviation bases. PMID:15121523

The SEER Readability Technique: How Practicable is It?

ERIC Educational Resources Information Center

Duffelmeyer, Frederick A.

1982-01-01

Evaluates the practicability of the Singer Eyeball Estimate of Readability (SEER) techniques with 32 college students. Reveals that only two of the students met SEER's criterion for being considered acceptable judges. Concludes that the criterion is overly stringent and proposes a revised criterion designed to make the SEER technique more…

Risk Factors for Cancer | Did You Know?

Cancer.gov

Age, weight, exposure to carcinogens, and genetics can increase the risk of developing cancer. Learn more from this Did You Know? video produced by NCI's Surveillance, Epidemiology, and End Results (SEER) program.

Comparison of prognostic nomograms based on different nodal staging systems in patients with resected gastric cancer.

PubMed

Wang, Zi-Xian; Qiu, Miao-Zhen; Jiang, Yu-Ming; Zhou, Zhi-Wei; Li, Guo-Xin; Xu, Rui-Hua

2017-01-01

Purpose: Previous studies addressing the optimal nodal staging system in patients with resected gastric cancer have shown inconsistent results, and the optimal system for development of prognostic nomograms remains unclear. In this study, we compared prognostic nomograms based on the metastatic lymph node (MLN) count, lymph node ratio (LNR), and log odds of metastatic lymph nodes (LODDS) to predict the 5-year overall survival in patients with resected gastric cancer. Methods: We analysed 15,320 patients with resected gastric cancer in the Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2010. Missing data were handled using multiple imputation. When assessed as a continuous covariate with restricted cubic splines, each MLN, LNR, and LODDS variable was incorporated into a nomogram with other significant prognosticators to predict the 5-year overall survival. A two-centre Chinese dataset (1,595 cases) was used as external validation data. Results: The discriminatory abilities of the MLN-, LNR-, and LODDS-based nomograms were comparable (concordance indices: 0.744, 0.741, and 0.744, respectively, in the SEER set, P > 0.152 for all pairwise comparisons; 0.715, 0.712, and 0.713, respectively, in the Chinese set, P > 0.445 for all pairwise comparisons). The discriminatory abilities of the three nomograms were all superior to the American Joint Committee on Cancer (AJCC) TNM classification (concordance indices: 0.713, P < 0.001 for all in the SEER set; and 0.693, P < 0.001 for all in the Chinese set). The discriminatory abilities of the nomograms were comparable regardless of the number of nodes examined. Moreover, decision curve analyses indicated similar net benefits of using the nomograms. Conclusion: MLN-, LNR-, and LODDS should be considered equally in the development of multivariate prognostic models and nomograms to refine the prediction of survival among patients with resected gastric cancer.

Impact of age on the survival of patients with liver cancer: an analysis of 27,255 patients in the SEER database.

PubMed

Zhang, Wenjie; Sun, Beicheng

2015-01-20

The risk of liver cancer (LC) is regarded as age dependent. However, the influence of age on its prognosis is controversial. The aim of our study was to compare the long-term survival of younger versus older patients with LC. In this retrospective study, we searched Surveillance, Epidemiology, and End-RESULTS (SEER) population-based data and identified 27,255 patients diagnosed with LC between 1988 and 2003. These patients were categorized into younger (45 years and under) and older age (over 45 years of age) groups. Five-year cancer specific survival data was obtained. Kaplan-Meier methods and multivariable Cox regression models were used to analyze long-term survival outcomes and risk factors. There were significant differences between groups with regards to pathologic grading, histologic type, stage, and tumor size (p < 0.001). The 5-year liver cancer specific survival (LCSS) rates in the younger and older age groups were 14.5% and 8.4%, respectively (p < 0.001 by univariate and multivariate analysis). A stratified analysis of age on cancer survival showed only localized and regional stages to be validated as independent predictors, but not for advanced stages. Compared to older patients, younger patients with LC have a higher LCSS after surgery, despite the poorer biological behavior of this carcinoma.

Retinoblastoma incidence patterns in the US Surveillance, Epidemiology, and End Results program.

PubMed

Wong, Jeannette R; Tucker, Margaret A; Kleinerman, Ruth A; Devesa, Susan S

2014-04-01

IMPORTANCE Several studies have found no temporal or demographic differences in the incidence of retinoblastoma except for age at diagnosis, whereas other studies have reported variations in incidence by sex and race/ethnicity. OBJECTIVE To examine updated US retinoblastoma incidence patterns by sex, age at diagnosis, laterality, race/ethnicity, and year of diagnosis. DESIGN, SETTING, AND PARTICIPANTS The Surveillance, Epidemiology, and End Results (SEER) databases were examined for retinoblastoma incidence patterns by demographic and tumor characteristics. We studied 721 children in SEER 18 registries, 659 in SEER 13 registries, and 675 in SEER 9 registries. MAIN OUTCOMES AND MEASURES Incidence rates, incidence rate ratios (IRRs), and annual percent changes in rates. RESULTS During 2000-2009 in SEER 18, there was a significant excess of total retinoblastoma among boys compared with girls (IRR, 1.18; 95% CI, 1.02 to 1.36), in contrast to earlier reports of a female predominance. Bilateral retinoblastoma among white Hispanic boys was significantly elevated relative to white non-Hispanic boys (IRR, 1.81; 95% CI, 1.22 to 2.79) and white Hispanic girls (IRR, 1.75; 95% CI, 1.11 to 2.91) because of less rapid decreases in bilateral rates since the 1990s among white Hispanic boys than among the other groups. Retinoblastoma rates among white non-Hispanics decreased significantly since 1992 among those younger than 1 year and since 1998 among those with bilateral disease. CONCLUSIONS AND RELEVANCE Although changes in the availability of prenatal screening practices for retinoblastoma may have contributed to these incidence patterns, further research is necessary to determine their actual effect on the changing incidence of retinoblastoma in the US population. In addition, consistent with other cancers, an excess of retinoblastoma diagnosed in boys suggests a potential effect of sex on cancer origin.

Using cancer registries to assess the accuracy of primary liver or intrahepatic bile duct cancer as the underlying cause of death, 1999-2010.

PubMed

Polednak, Anthony P

2013-01-01

Inaccuracies in primary liver cancer (ie, excluding intrahepatic bile duct [IHBD]) or IHBD cancer as the underlying cause of death on the death certificate vs the cancer site in a cancer registry should be considered in surveillance of mortality rates in the population. Concordance between cancer site on the death record (1999-2010) and diagnosis (1973-2010) in the database for 9 cancer registries of the Surveillance, Epidemiology, and End Results (SEER) Program was examined for decedents with only 1 cancer recorded. Overreporting of deaths coded to liver cancer (ie, lack of confirmation in SEER) was largely balanced by underreporting (ie, a cancer site other than liver cancer in SEER). For IHBD cancer, overreporting was much more frequent than underreporting. Using modified rates, based on the most accurate numerators available, had little impact on trends for liver cancer in the SEER population, which were similar to trends for the entire US population based on routine statistics. An increase in the death rate for IHBD cancer, however, was no longer evident after modification. The findings support the use of routine data on underlying cause of death for surveillance of trends in death rates for liver cancer but not for IHBD cancer. Additional population-based cancer registries could potentially be used for surveillance of recent and future trends in mortality rates from these cancers.

Early-season, Low-dose Applications of Endothall to Selectively Control Curlyleaf Pondweed in Minnesota Lakes

DTIC Science & Technology

2008-06-01

aquatic plants ( Westerdahl and Getsinger 1988). The mode of action for endothall has been described as a contact-type herbicide that may cause rapid...pondweed (Netherland et al. 1991, 2000; Madsen 1997a; Pennington et al. 2001; Poovey et al. 2002; Skogerboe et al. 2004; Westerdahl and Getsinger 1988...31:3-16. Westerdahl , H. E., and K. D. Getsinger (eds.). 1988. Aquatic plant identification and herbicide use guide; Vol. II: Aquatic plants and

SEER Data & Software

Cancer.gov

Options for accessing datasets for incidence, mortality, county populations, standard populations, expected survival, and SEER-linked and specialized data. Plus variable definitions, documentation for reporting and using datasets, statistical software (SEER*Stat), and observational research resources.

48 CFR 22.403-4 - Department of Labor regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Department of Labor... 22.403 and Reorganization Plan No. 14 of 1950 (3 CFR 1949-53 Comp., p. 1007), the Secretary of Labor..., Feb. 18, 1988, as amended at 66 FR 2141, Jan. 10, 2001; 66 FR 53480, Oct. 22, 2001] ...

SEER Abstracting Tool (SEER*Abs)

Cancer.gov

With this customizable tool, registrars can collect and store data abstracted from medical records. Download the software and find technical support and reference manuals. SEER*Abs has features for creating records, managing abstracting work and data, accessing reference data, and integrating edits.

MindSeer: a portable and extensible tool for visualization of structural and functional neuroimaging data.

PubMed

Moore, Eider B; Poliakov, Andrew V; Lincoln, Peter; Brinkley, James F

2007-10-15

Three-dimensional (3-D) visualization of multimodality neuroimaging data provides a powerful technique for viewing the relationship between structure and function. A number of applications are available that include some aspect of 3-D visualization, including both free and commercial products. These applications range from highly specific programs for a single modality, to general purpose toolkits that include many image processing functions in addition to visualization. However, few if any of these combine both stand-alone and remote multi-modality visualization in an open source, portable and extensible tool that is easy to install and use, yet can be included as a component of a larger information system. We have developed a new open source multimodality 3-D visualization application, called MindSeer, that has these features: integrated and interactive 3-D volume and surface visualization, Java and Java3D for true cross-platform portability, one-click installation and startup, integrated data management to help organize large studies, extensibility through plugins, transparent remote visualization, and the ability to be integrated into larger information management systems. We describe the design and implementation of the system, as well as several case studies that demonstrate its utility. These case studies are available as tutorials or demos on the associated website: http://sig.biostr.washington.edu/projects/MindSeer. MindSeer provides a powerful visualization tool for multimodality neuroimaging data. Its architecture and unique features also allow it to be extended into other visualization domains within biomedicine.

Tissues from population-based cancer registries: a novel approach to increasing research potential.

PubMed

Goodman, Marc T; Hernandez, Brenda Y; Hewitt, Stephen; Lynch, Charles F; Coté, Timothy R; Frierson, Henry F; Moskaluk, Christopher A; Killeen, Jeffrey L; Cozen, Wendy; Key, Charles R; Clegg, Limin; Reichman, Marsha; Hankey, Benjamin F; Edwards, Brenda

2005-07-01

Population-based cancer registries, such as those included in the Surveillance, Epidemiology, and End-Results (SEER) Program, offer tremendous research potential beyond traditional surveillance activities. We describe the expansion of SEER registries to gather formalin-fixed, paraffin-embedded tissue from cancer patients on a population basis. Population-based tissue banks have the advantage of providing an unbiased sampling frame for evaluating the public health impact of genes or protein targets that may be used for therapeutic or diagnostic purposes in defined communities. Such repositories provide a unique resource for testing new molecular classification schemes for cancer, validating new biologic markers of malignancy, prognosis and progression, assessing therapeutic targets, and measuring allele frequencies of cancer-associated genetic polymorphisms or germline mutations in representative samples. The assembly of tissue microarrays will allow for the use of rapid, large-scale protein-expression profiling of tumor samples while limiting depletion of this valuable resource. Access to biologic specimens through SEER registries will provide researchers with demographic, clinical, and risk factor information on cancer patients with assured data quality and completeness. Clinical outcome data, such as disease-free survival, can be correlated with previously validated prognostic markers. Furthermore, the anonymity of the study subject can be protected through rigorous standards of confidentiality. SEER-based tissue resources represent a step forward in true, population-based tissue repositories of tumors from US patients and may serve as a foundation for molecular epidemiology studies of cancer in this country.

Cancer Incidence in the U.S. Military Population: Comparison with Rates from the SEER Program

PubMed Central

Zhu, Kangmin; Devesa, Susan S.; Wu, Hongyu; Zahm, Shelia H.; Jatoi, Ismail; Anderson, William F.; Peoples, George; Maxwell, Larry G.; Granger, Elder; Potter, John F.; McGlynn, Katherine A.

2009-01-01

The U.S. active-duty military population may differ from the U.S. general population in its exposure to cancer risk factors and access to medical care. Yet, it is not known if cancer incidence rates differ between these two populations. We therefore compared the incidence of four cancers common in U.S. adults (lung, colorectum, prostate, and breast cancers) and two cancers more common in U.S. young adults (testicular and cervical cancers) in the military and general populations. Data from the Department of Defense's Automated Central Tumor Registry (ACTUR) and the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) nine cancer registries for the years 1990-2004 for persons aged 20-59 years were analyzed. Incidence rates were significantly lower in the military population for colorectal cancer in white men, lung cancer in white and black men and white women, and cervical cancer in black women. In contrast, incidence rates of breast and prostate cancers were significantly higher in the military among both whites and blacks. Incidence rates of testicular cancer did not differ between ACTUR and SEER. Although the numbers of diagnoses among military personnel were relatively small for temporal trend analysis, we found a more prominent increase in prostate cancer in ACTUR than in SEER. Overall, these results suggest that cancer patterns may differ between military and non-military populations. Further studies are needed to confirm these findings and explore contributing factors. PMID:19505907

Marital status, treatment, and survival in patients with glioblastoma multiforme: a population based study.

PubMed

Chang, Susan M; Barker, Fred G

2005-11-01

Social factors influence cancer treatment choices, potentially affecting patient survival. In the current study, the authors studied the interrelations between marital status, treatment received, and survival in patients with glioblastoma multiforme (GM), using population-based data. The data source was the Surveillance, Epidemiology, and End Results (SEER) Public Use Database, 1988-2001, 2004 release, all registries. Multivariate logistic, ordinal, and Cox regression analyses adjusted for demographic and clinical variables were used. Of 10,987 patients with GM, 67% were married, 31% were unmarried, and 2% were of unknown marital status. Tumors were slightly larger at the time of diagnosis in unmarried patients (49% of unmarried patients had tumors larger than 45 mm vs. 45% of married patients; P = 0.004, multivariate analysis). Unmarried patients were less likely to undergo surgical resection (vs. biopsy; 75% of unmarried patients vs. 78% of married patients) and were less likely to receive postoperative radiation therapy (RT) (70% of unmarried patients vs. 79% of married patients). On multivariate analysis, the odds ratio (OR) for resection (vs. biopsy) in unmarried patients was 0.88 (95% confidence interval [95% CI], 0.79-0.98; P = 0.02), and the OR for RT in unmarried patients was 0.69 (95% CI, 0.62-0.77; P < 0.001). Unmarried patients more often refused both surgical resection and RT. Unmarried patients who underwent surgical resection and RT were found to have a shorter survival than similarly treated married patients (hazard ratio for unmarried patients, 1.10; P = 0.003). Unmarried patients with GM presented with larger tumors, were less likely to undergo both surgical resection and postoperative RT, and had a shorter survival after diagnosis when compared with married patients, even after adjustment for treatment and other prognostic factors. (c) 2005 American Cancer Society.

Survival rate variation with different histological subtypes of poor prognostic male anal squamous cell carcinoma: a population-based study.

PubMed

Wan, Zihao; Huang, Zhihao; Vikash, Vikash; Rai, Kelash; Vikash, Sindhu; Chen, Liaobin; Li, Jingfeng

2017-10-13

The prognosis of male anal squamous cell carcinoma (MASCC) and female anal squamous cell carcinoma (FASCC) is variable. The influence of tumor subtype on the survival rate and gender is poorly known. Our study is the largest population-based study and aims to outline the difference in survival between MASCC and FASCC patients. A retrospective population-based study was performed to compare the disease-specific mortalities (DSMs) between genders related to the tumor subtypes. The Surveillance, Epidemiology, and End Results (SEER) program database was employed to obtain the data from January 1988 to December 2014. A total of 4,516, (3,249 males and 1,267 females), patients with anal squamous cell carcinomas (ASCC) were investigated. The 5-year DSMs were 24.18% and 18.08% for men and women, respectively. The univariate analysis of the male basaloid squamous cell carcinoma (BSCC) and cloacogenic carcinoma (CC) patients demonstrated higher DSMs (P <0.001). Moreover, in the multivariate analysis, BSCC and CC were associated with soaring DSMs in male patients (P < 0.05). In the cohort of BSCC and CC patients, male patients demonstrated a considerable decrease in survival rate compared to females. A more precise classification of ASCC and individualized management for MASCC are warranted.

No consistent relationship of glioblastoma incidence and cytomegalovirus seropositivity in whites, blacks, and Hispanics.

PubMed

Lehrer, Steven; Green, Sheryl; Ramanathan, Lakshmi; Rosenzweig, Kenneth; Labombardi, Vincent

2012-03-01

Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly cytomegalovirus (CMV). In one report, 80% of patients with newly diagnosed glioblastoma multiforme had detectable cytomegalovirus DNA in their peripheral blood, while sero-positive normal donors and other surgical patients did not exhibit detectable virus. However, another study reported that five glioblastoma patients showed no circulating CMV detected either with RT-PCR or blood culture. We utilized Cytomegalovirus Seroprevalence in the United States data from the National Health and Nutrition Examination Surveys, 1988-2004. Glioblastoma Incidence Rates 2004-2008 by race and gender are from Cancer of the Brain and Other Nervous System - SEER Stat Fact Sheets (http://seer.cancer.gov/statfacts/html/brain.html). Statistical significance was determined from published 95% confidence intervals. CMV seroprevalence rates are not consistently related to glioblastoma incidence rates. CMV seroprevalence is significantly lower in whites than in blacks or Hispanics (Mexican Americans), while glioblastoma incidence is higher. However, both CMV seroprevalence and glioblastoma incidence are higher in Hispanics than in blacks. CMV seroprevalence rates are significantly higher in women, 55.5% (53.3-57.7, mean ± 95% CI) than men, 45.2% (42.4-48.0), although glioblastoma is more common in men. A possible CMV-glioblastoma association cannot be readily substantiated with CMV seropositivity rates.

Variable & Recode Definitions - SEER Documentation

Cancer.gov

Resources that define variables and provide documentation for reporting using SEER and related datasets. Choose from SEER coding and staging manuals plus instructions for recoding behavior, site, stage, cause of death, insurance, and several additional topics. Also guidance on months survived, calculating Hispanic mortality, and site-specific surgery.

Informatics research using publicly available pathology data.

PubMed

Berman, Jules J

2011-01-24

The day has not arrived when pathology departments freely distribute their collected anatomic and clinical data for research purposes. Nonetheless, several valuable public domain data sets are currently available, from the U.S. Government. Two public data sets of special interest to pathologists are the SEER (the U.S. National Cancer Institute's Surveillance, Epidemiology and End Results program) public use data files, and the CDC (Center for Disease Control and Prevention) mortality files. The SEER files contain about 4 million de-identified cancer records, dating from 1973. The CDC mortality files contain approximately 85 million de-identified death records, dating from 1968. This editorial briefly describes both data sources, how they can be obtained, and how they may be used for pathology research.

Catalog of earthquake hypocenters at Alaskan volcanoes: January 1, 2000 through December 31, 2001

USGS Publications Warehouse

Dixon, James P.; Stihler, Scott D.; Power, John A.; Tytgat, Guy; Estes, Steve; Moran, Seth C.; Paskievitch, John; McNutt, Stephen R.

2002-01-01

The Alaska Volcano Observatory (AVO), a cooperative program of the U.S. Geological Survey, the Geophysical Institute of the University of Alaska Fairbanks, and the Alaska Division of Geological and Geophysical Surveys, has maintained seismic monitoring networks at potentially active volcanoes in Alaska since 1988 (Power and others, 1993; Jolly and others, 1996; Jolly and others, 2001). The primary objectives of this program are the seismic surveillance of active, potentially hazardous, Alaskan volcanoes and the investigation of seismic processes associated with active volcanism. This catalog reflects the status and evolution of the seismic monitoring program, and presents the basic seismic data for the time period January 1, 2000, through December 31, 2001. For an interpretation of these data and previously recorded data, the reader should refer to several recent articles on volcano related seismicity on Alaskan volcanoes in Appendix G.The AVO seismic network was used to monitor twenty-three volcanoes in real time in 2000-2001. These include Mount Wrangell, Mount Spurr, Redoubt Volcano, Iliamna Volcano, Augustine Volcano, Katmai Volcanic Group (Snowy Mountain, Mount Griggs, Mount Katmai, Novarupta, Trident Volcano, Mount Mageik, Mount Martin), Aniakchak Crater, Pavlof Volcano, Mount Dutton, Isanotski Peaks, Shishaldin Volcano, Fisher Caldera, Westdahl Peak, Akutan Peak, Makushin Volcano, Great Sitkin Volcano, and Kanaga Volcano (Figure 1). AVO located 1551 and 1428 earthquakes in 2000 and 2001, respectively, on and around these volcanoes.Highlights of the catalog period (Table 1) include: volcanogenic seismic swarms at Shishaldin Volcano between January and February 2000 and between May and June 2000; an eruption at Mount Cleveland between February and May 2001; episodes of possible tremor at Makushin Volcano starting March 2001 and continuing through 2001, and two earthquake swarms at Great Sitkin Volcano in 2001.This catalog includes: (1) earthquake origin times, hypocenters, and magnitudes with summary statistics describing the earthquake location quality; (2) a description of instruments deployed in the field and their locations; (3) a description of earthquake detection, recording, analysis, and data archival systems; (4) station parameters and velocity models used for earthquake locations; (5) a summary of daily station usage throughout the catalog period; and (6) all HYPOELLIPSE files used to determine the earthquake locations presented in this report.

SEER Cancer Registry Biospecimen Research: Yesterday and Tomorrow

PubMed Central

Altekruse, Sean F.; Rosenfeld, Gabriel E.; Carrick, Danielle M.; Pressman, Emilee J.; Schully, Sheri D.; Mechanic, Leah E.; Cronin, Kathleen A.; Hernandez, Brenda Y.; Lynch, Charles F.; Cozen, Wendy; Khoury, Muin J.; Penberthy, Lynne T.

2014-01-01

The National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) registries have been a source of biospecimens for cancer research for decades. Recently, registry-based biospecimen studies have become more practical, with the expansion of electronic networks for pathology and medical record reporting. Formalin-fixed paraffin-embedded specimens are now used for next-generation sequencing and other molecular techniques. These developments create new opportunities for SEER biospecimen research. We evaluated 31 research articles published during 2005–2013 based on author confirmation that these studies involved linkage of SEER data to biospecimens. Rather than providing an exhaustive review of all possible articles, our intent was to indicate the breadth of research made possible by such a resource. We also summarize responses to a 2012 questionnaire that was broadly distributed to the NCI intra- and extramural biospecimen research community. This included responses from 30 investigators who had used SEER biospecimens in their research. The survey was not intended to be a systematic sample, but instead to provide anecdotal insight on strengths, limitations, and the future of SEER biospecimen research. Identified strengths of this research resource include biospecimen availability, cost, and annotation of data, including demographic information, stage, and survival. Shortcomings include limited annotation of clinical attributes such as detailed chemotherapy history and recurrence, and timeliness of turnaround following biospecimen requests. A review of selected SEER biospecimen articles, investigator feedback, and technological advances reinforced our view that SEER biospecimen resources should be developed. This would advance cancer biology, etiology, and personalized therapy research. PMID:25472677

The role of poverty rate and racial distribution in the geographic clustering of breast cancer survival among older women: a geographic and multilevel analysis.

PubMed

Schootman, Mario; Jeffe, Donna B; Lian, Min; Gillanders, William E; Aft, Rebecca

2009-03-01

The authors examined disparities in survival among women aged 66 years or older in association with census-tract-level poverty rate, racial distribution, and individual-level factors, including patient-, treatment-, and tumor-related factors, utilization of medical care, and mammography use. They used linked data from the 1992-1999 Surveillance, Epidemiology, and End Results (SEER) programs, 1991-1999 Medicare claims, and the 1990 US Census. A geographic information system and advanced statistics identified areas of increased or reduced breast cancer survival and possible reasons for geographic variation in survival in 2 of the 5 SEER areas studied. In the Detroit, Michigan, area, one geographic cluster of shorter-than-expected breast cancer survival was identified (hazard ratio (HR) = 1.60). An additional area where survival was longer than expected approached statistical significance (HR = 0.4; P = 0.056). In the Atlanta, Georgia, area, one cluster of shorter- (HR = 1.81) and one cluster of longer-than-expected (HR = 0.72) breast cancer survival were identified. Stage at diagnosis and census-tract poverty (and patient's race in Atlanta) explained the geographic variation in breast cancer survival. No geographic clusters were identified in the 3 other SEER programs. Interventions to reduce late-stage breast cancer, focusing on areas of high poverty and targeting African Americans, may reduce disparities in breast cancer survival in the Detroit and Atlanta areas.

Characterizing inflammatory breast cancer among Arab Americans in the California, Detroit and New Jersey Surveillance, Epidemiology and End Results (SEER) registries (1988-2008).

PubMed

Hirko, Kelly A; Soliman, Amr S; Banerjee, Mousumi; Ruterbusch, Julie; Harford, Joe B; Chamberlain, Robert M; Graff, John J; Merajver, Sofia D; Schwartz, Kendra

2013-12-01

Inflammatory breast cancer (IBC) is characterized by an apparent geographical distribution in incidence, being more common in North Africa than other parts of the world. Despite the rapid growth of immigrants to the United States from Arab nations, little is known about disease patterns among Arab Americans because a racial category is rarely considered for this group. The aim of this study was to advance our understanding of the burden of IBC in Arab ethnic populations by describing the proportion of IBC among different racial groups, including Arab Americans from the Detroit, New Jersey and California Surveillance, Epidemiology and End Results (SEER) registries. We utilized a validated Arab surname algorithm to identify women of Arab descent from the SEER registries. Differences in the proportion of IBC out of all breast cancer and IBC characteristics by race and menopausal status were evaluated using chi-square tests for categorical variables, t-tests and ANOVA tests for continuous variables, and log-rank tests for survival data. We modeled the association between race and IBC among all women with breast cancer using hierarchical logistic regression models, adjusting for individual and census tract-level variables. Statistically significant differences in the proportion of IBC out of all breast cancers by race were evident. In a hierarchical model, adjusting for age, estrogen and progesterone receptor, human epidermal growth receptor 2, registry and census-tract level education, Arab-Americans (OR=1.5, 95% CI=1.2,1.9), Hispanics (OR=1.2, 95% CI=1.1,1.3), Non-Hispanic Blacks (OR=1.3, 95% CI=1.2, 1.4), and American Indians/Alaskans (OR=1.9, 95% CI=1.1, 3.4) had increased odds of IBC, while Asians (OR=0.6, 95% CI=0.6, 0.7) had decreased odds of IBC as compared to Non-Hispanic Whites. IBC may be more common among certain minority groups, including Arab American women. Understanding the descriptive epidemiology of IBC by race may generate hypotheses about risk factors for this aggressive disease. Future research should focus on etiologic factors that may explain these differences.

Non-Rhabdomyosarcoma Soft Tissue Sarcomas in Children: A Surveillance, Epidemiology, and End Results Analysis Validating COG Risk Stratifications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Waxweiler, Timothy V., E-mail: timothy.waxweiler@ucdenver.edu; Rusthoven, Chad G.; Proper, Michelle S.

Purpose: Non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) are a heterogeneous group of sarcomas that encompass over 35 histologies. With an incidence of ∼500 cases per year in the United States in those <20 years of age, NRSTS are rare and therefore difficult to study in pediatric populations. We used the large Surveillance, Epidemiology, and End Results (SEER) database to validate the prognostic ability of the Children's Oncology Group (COG) risk classification system and to define patient, tumor, and treatment characteristics. Methods and Materials: From SEER data from 1988 to 2007, we identified patients ≤18 years of age with NRSTS. Data for age, sex,more » year of diagnosis, race, registry, histology, grade, primary size, primary site, stage, radiation therapy, and survival outcomes were analyzed. Patients with nonmetastatic grossly resected low-grade tumors of any size or high-grade tumors ≤5 cm were considered low risk. Cases of nonmetastatic tumors that were high grade, >5 cm, or unresectable were considered intermediate risk. Patients with nodal or distant metastases were considered high risk. Results: A total of 941 patients met the review criteria. On univariate analysis, black race, malignant peripheral nerve sheath (MPNST) histology, tumors >5 cm, nonextremity primary, lymph node involvement, radiation therapy, and higher risk group were associated with significantly worse overall survival (OS) and cancer-specific survival (CSS). On multivariate analysis, MPNST histology, chemotherapy-resistant histology, and higher risk group were significantly poor prognostic factors for OS and CSS. Compared to low-risk patients, intermediate patients showed poorer OS (hazard ratio [HR]: 6.08, 95% confidence interval [CI]: 3.53-10.47, P<.001) and CSS (HR: 6.27; 95% CI: 3.44-11.43, P<.001), and high-risk patients had the worst OS (HR: 13.35, 95% CI: 8.18-21.76, P<.001) and CSS (HR: 14.65, 95% CI: 8.49-25.28, P<.001). Conclusions: The current COG risk group stratification for children with NRSTS has been validated with a large number of children in the SEER database.« less

Cancer incidence among Arab Americans in California, Detroit, and New Jersey SEER registries.

PubMed

Bergmans, Rachel; Soliman, Amr S; Ruterbusch, Julie; Meza, Rafael; Hirko, Kelly; Graff, John; Schwartz, Kendra

2014-06-01

We calculated cancer incidence for Arab Americans in California; Detroit, Michigan; and New Jersey, and compared rates with non-Hispanic, non-Arab Whites (NHNAWs); Blacks; and Hispanics. We conducted a study using population-based data. We linked new cancers diagnosed in 2000 from the Surveillance, Epidemiology, and End Results Program (SEER) to an Arab surname database. We used standard SEER definitions and methodology for calculating rates. Population estimates were extracted from the 2000 US Census. We calculated incidence and rate ratios. Arab American men and women had similar incidence rates across the 3 geographic regions, and the rates were comparable to NHNAWs. However, the thyroid cancer rate was elevated among Arab American women compared with NHNAWs, Hispanics, and Blacks. For all sites combined, for prostate and lung cancer, Arab American men had a lower incidence than Blacks and higher incidence than Hispanics in all 3 geographic regions. Arab American male bladder cancer incidence was higher than that in Hispanics and Blacks in these regions. Our results suggested that further research would benefit from the federal recognition of Arab Americans as a specified ethnicity to estimate and address the cancer burden in this growing segment of the population.

Towards the Development of an Academic Word List for Applied Linguistics Research Articles

ERIC Educational Resources Information Center

Khani, Reza; Tazik, Khalil

2013-01-01

Academic vocabulary, as the most challenging aspect of language learning in EAP and ESP contexts, has received much attention in the last few decades (e.g. Laufer, 1988; Sutarsyah, et al., 1994; Laufer and Nation, 1999; Coxhead, 2000; Nation, 2001a, 2001b; Wang et al., 2008; Martinez et al., 2009). The major attainments of these studies were…

Seer 2008 Session III Discussant Remarks

ERIC Educational Resources Information Center

Medina, Jacquie

2009-01-01

Three research abstracts dealt with program outcomes and the factors that affect them. Morgan (2008) dealt with the potential influence of sensation-seeking personality traits on perceived risk and perceived competence in adventure experiences. Two abstracts by Bobilya, Akey, and Mitchell, Jr. (2008) and Austin, Martin, Mittelstaedt, Schanning,…

Development of a Cost Estimation Process for Human Systems Integration Practitioners During the Analysis of Alternatives

DTIC Science & Technology

2010-12-01

processes. Novice estimators must often use of these complicated cost estimation tools (e.g., ACEIT , SEER-H, SEER-S, PRICE-H, PRICE-S, etc.) until...However, the thesis will leverage the processes embedded in cost estimation tools such as the Automated Cost Estimating Integration Tool ( ACEIT ) and the

The Impact of Intensity Modulated Radiation Therapy on Hospitalization Outcomes in the SEER-Medicare Population With Anal Squamous Cell Carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pollom, Erqi L., E-mail: erqiliu@stanford.edu; Wang, Guanying; Harris, Jeremy P.

Purpose: We examined the impact of intensity modulated radiation therapy (IMRT) on hospitalization rates in the Surveillance, Epidemiology, and End Results (SEER)–Medicare population with anal squamous cell carcinoma (SCC). Methods and Materials: We performed a retrospective cohort study using the SEER-Medicare database. We identified patients with nonmetastatic anal SCC diagnosed between 2001 and 2011 and treated with chemoradiation therapy. We assessed the relation between IMRT and first hospitalization by use of a multivariate competing-risk model, as well as instrumental variable analysis, using provider IMRT affinity as our instrument. Results: Of the 1165 patients included in our study, 458 (39%) receivedmore » IMRT. IMRT use increased over time and was associated more with regional and provider characteristics than with patient characteristics. The 3- and 6-month cumulative incidences of first hospitalization were 41.9% (95% confidence interval [CI], 37.3%-46.4%) and 47.6% (95% CI, 43.0%-52.2%), respectively, for the IMRT cohort and 46.7% (95% CI, 43.0%-50.4%) and 52.1% (95% CI, 48.4%-55.7%), respectively, for the non-IMRT cohort. IMRT was associated with a decreased hazard of first hospitalization compared with 3-dimensional radiation techniques (hazard ratio, 0.70; 95% CI, 0.58-0.84; P=.0002). Instrumental variable analysis suggested an even greater reduction in hospitalizations with IMRT after controlling for unmeasured confounders. There was a trend toward improved overall survival with IMRT, with an adjusted hazard ratio of 0.77 (95% CI, 0.59-1.00; P=.05). Conclusions: The use of IMRT is associated with reduced hospitalizations in elderly patients with anal SCC. Further work is warranted to understand the long-term health and cost impact of IMRT, particularly for patient subgroups most at risk of toxicity and hospitalization.« less

Improved survival of baby boomer women with early-stage uterine cancer: A Surveillance, Epidemiology and End Results (SEER) Study.

PubMed

Elshaikh, Mohamed A; Ruterbusch, Julie; Cote, Michele L; Cattaneo, Richard; Munkarah, Adnan R

2013-11-01

To study the prognostic impact of baby boomer (BB) generation on survival end-points of patients with early-stage endometrial carcinoma (EC). Data were obtained from the SEER registry between 1988-2009. Inclusion criteria included women who underwent hysterectomy for stage I-II EC. Patients were divided into two birth cohorts: BB (women born between 1946 and 1964) and pre-boomers (PB) (born between 1926 and 1945). A total of 30,956 patients were analyzed. Considering that women in the PB group were older than those of the BB generation, the statistical analysis was limited to women 50-59 years of age at the time of diagnosis (n=11,473). Baby boomers had a significantly higher percentage of endometrioid histology (p<0.0001), higher percentage of African American women (p<0.0001), lower tumor grade (p<0.0001), higher number of dissected lymph nodes (LN) (p<0.0001), and less utilization of adjuvant radiation therapy (p=0.0003). Overall survival was improved in women in the BB generation compared to the PB generation (p=0.0003) with a trend for improved uterine cancer-specific survival (p=0.0752). On multivariate analysis, birth cohort (BB vs. PB) was not a significant predictor of survival end-points. Factors predictive of survival included: tumor grade, FIGO stage, African-American race, and increased number of dissected LN. Our study suggests that the survival of BB women between 50-60 years of age is better compared to women in the PB generation. As more BB patients are diagnosed with EC, further research is warranted.

AIM-120 Advanced Medium Range Air-to-Air Missile (AMRAAM)

DTIC Science & Technology

2013-12-01

lilA (DAB) DAE Program Review Start Production Deliveries Complete DAOT&E (Air Force) Complete IOT &E!Captive Ca ... Initial EQuipage Milestone... IOT &E OCT 1983 N/A N/A OCT 1983 Certification FEB 1986 FEB 1986 AUG 1986 FEB 1986 Milestone IIIA (DAB) JUN 1987 JUN 1987 DEC 1987 JUN 1987 DAE...Program Review MAY 1988 MAY 1988 NOV 1988 MAY 1988 Start Production Deliveries SEP 1988 SEP 1988 MAR 1989 SEP 1988 Complete D/ IOT &E (Air Force) JAN 1989 JAN

Use of Stereotactic Radiosurgery for Brain Metastases From Non-Small Cell Lung Cancer in the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halasz, Lia M., E-mail: lhalasz@uw.edu; Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts; Weeks, Jane C.

2013-02-01

Purpose: The indications for treatment of brain metastases from non-small cell lung cancer (NSCLC) with stereotactic radiosurgery (SRS) remain controversial. We studied patterns, predictors, and cost of SRS use in elderly patients with NSCLC. Methods and Materials: Using the Surveillance, Epidemiology, and End Results-Medicare (SEER-Medicare) database, we identified patients with NSCLC who were diagnosed with brain metastases between 2000 and 2007. Our cohort included patients treated with radiation therapy and not surgical resection as initial treatment for brain metastases. Results: We identified 7684 patients treated with radiation therapy within 2 months after brain metastases diagnosis, of whom 469 (6.1%) casesmore » had billing codes for SRS. Annual SRS use increased from 3.0% in 2000 to 8.2% in 2005 and varied from 3.4% to 12.5% by specific SEER registry site. After controlling for clinical and sociodemographic characteristics, we found SRS use was significantly associated with increasing year of diagnosis, specific SEER registry, higher socioeconomic status, admission to a teaching hospital, no history of participation in low-income state buy-in programs (a proxy for Medicaid eligibility), no extracranial metastases, and longer intervals from NSCLC diagnosis. The average cost per patient associated with radiation therapy was 2.19 times greater for those who received SRS than for those who did not. Conclusions: The use of SRS in patients with metastatic NSCLC increased almost 3-fold from 2000 to 2005. In addition, we found significant variations in SRS use across SEER registries and socioeconomic quartiles. National practice patterns in this study suggested both a lack of consensus and an overall limited use of the approach among elderly patients before 2008.« less

Dedifferentiated chondrosarcoma: A survival analysis of 159 cases from the SEER database (2001-2011).

PubMed

Strotman, Patrick K; Reif, Taylor J; Kliethermes, Stephanie A; Sandhu, Jasmin K; Nystrom, Lukas M

2017-08-01

Dedifferentiated chondrosarcoma is a rare malignancy with reported 5-year overall survival rates ranging from 7% to 24%. The purpose of this investigation is to determine the overall survival of dedifferentiated chondrosarcoma in a modern patient series and how it is impacted by patient demographics, tumor characteristics, and surgical treatment factors. This is a retrospective review of the Surveillance, Epidemiology, and End Results (SEER) database from 2001 to 2011. Kaplan Meier analyses were used for overall and disease-specific survival. Univariable and multivariable cox regression models were used to identify prognostic factors. Five year overall- and disease-specific survival was 18% (95% CI: 12-26%) and 28% (95% CI: 18-37%), respectively. Individuals with extremity tumors had a worse prognosis than individuals with a primary tumor in the chest wall or axial skeleton (HR 0.20, 95% CI: 0.07-0.56; P = 0.002 and HR 0.60, 95% CI: 0.36-0.99; P = 0.04, respectively). Patients with AJCC stage III or IV disease (HR 2.51, 95% CI: 1.50-4.20; P = 0.001), tumors larger than 8 cm (HR 2.17, 95% CI: 1.11-4.27; P = 0.046), metastatic disease at diagnosis (HR 3.25, 95% CI: 1.98-5.33; P < 0.001), and those treated without surgical resection (amputation: HR 0.43, 95% CI 0.23-0.80; P = 0.01; limb salvage/non-amputation resection: HR 0.41, 95% CI: 0.24-0.69; P = 0.001) had a significant increase in risk of mortality. The overall prognosis of dedifferentiated chondrosarcoma is poor with a 5-year overall survival of 18%. Patients with a primary tumor located in the chest wall had a better prognosis. Tumors larger than 8 cm, presence of metastases at diagnosis, and treatment without surgical resection were significant predictors of mortality. © 2017 Wiley Periodicals, Inc.

Comparison of quadrant-specific breast cancer incidence trends in the United States and England between 1975 and 2013.

PubMed

Bright, C J; Rea, D W; Francis, A; Feltbower, R G

2016-10-01

UK breast cancer incidence rates suggest that upper outer quadrant (UOQ) cancers have risen disproportionately compared with other areas over time. We aimed to provide a comparison of the trend in quadrant-specific breast cancer incidence between the United States (US) and England, and determine whether a disproportionate UOQ increase is present. Surveillance Epidemiology and End Results (SEER) cancer registry data were obtained on 630,007 female breast cancers from 1975 to 2013. English cancer registry data were obtained on 1,121,134 female breast cancers from 1979 to 2013. Temporal incidence changes were analysed using negative binomial regression. Interaction terms determined whether incidence changes were similar between sites. English breast cancer incidence in the UOQ rose significantly from 13% to 28% from 1979 to 2013 whereas no significant increase was observed among SEER data. The significant interaction between quadrant and year of diagnosis (p<0.001) in both SEER and English data indicates that breast cancer incidence in each quadrant changed at a different rate. Incidence in the UOQ rose disproportionately compared to the nipple (SEER IRR=0.81, p<0.001; England IRR=0.78, p<0.001) and axillary tail (SEER IRR=0.87, p=0.018; England IRR=0.69, p<0.001) in both SEER and England. In addition, incidence rose disproportionately in the UOQ compared to non-site-specific tumours in England (Overlapping lesions IRR=0.81, p=0.002; NOS IRR=0.78, p<0.001). The proportion of non-site-specific tumours was substantially higher in England than SEER throughout the study period (62% in England; 39% in SEER). Breast cancer incidence in the UOQ increased disproportionately compared to non-site-specific tumours in England but not in SEER, likely due to the decrease in non-site-specific tumours observed in England over time. There may be real differences in incidence between the two countries, possibly due to differences in aetiology, but is much more likely to be an artefact of changing data collection methods and improvements in site coding in either country. Copyright © 2016 Elsevier Ltd. All rights reserved.

Survival rate variation with different histological subtypes of poor prognostic male anal squamous cell carcinoma: a population-based study

PubMed Central

Rai, Kelash; Vikash, Sindhu; Chen, Liaobin; Li, Jingfeng

2017-01-01

Background and objective The prognosis of male anal squamous cell carcinoma (MASCC) and female anal squamous cell carcinoma (FASCC) is variable. The influence of tumor subtype on the survival rate and gender is poorly known. Our study is the largest population-based study and aims to outline the difference in survival between MASCC and FASCC patients. Methods A retrospective population-based study was performed to compare the disease-specific mortalities (DSMs) between genders related to the tumor subtypes. The Surveillance, Epidemiology, and End Results (SEER) program database was employed to obtain the data from January 1988 to December 2014. Results A total of 4,516, (3,249 males and 1,267 females), patients with anal squamous cell carcinomas (ASCC) were investigated. The 5-year DSMs were 24.18% and 18.08% for men and women, respectively. The univariate analysis of the male basaloid squamous cell carcinoma (BSCC) and cloacogenic carcinoma (CC) patients demonstrated higher DSMs (P <0.001). Moreover, in the multivariate analysis, BSCC and CC were associated with soaring DSMs in male patients (P < 0.05). Conclusions In the cohort of BSCC and CC patients, male patients demonstrated a considerable decrease in survival rate compared to females. A more precise classification of ASCC and individualized management for MASCC are warranted. PMID:29137429

Cancer Incidence Among Arab Americans in California, Detroit, and New Jersey SEER Registries

PubMed Central

Bergmans, Rachel; Ruterbusch, Julie; Meza, Rafael; Hirko, Kelly; Graff, John; Schwartz, Kendra

2014-01-01

Objectives. We calculated cancer incidence for Arab Americans in California; Detroit, Michigan; and New Jersey, and compared rates with non-Hispanic, non-Arab Whites (NHNAWs); Blacks; and Hispanics. Methods. We conducted a study using population-based data. We linked new cancers diagnosed in 2000 from the Surveillance, Epidemiology, and End Results Program (SEER) to an Arab surname database. We used standard SEER definitions and methodology for calculating rates. Population estimates were extracted from the 2000 US Census. We calculated incidence and rate ratios. Results. Arab American men and women had similar incidence rates across the 3 geographic regions, and the rates were comparable to NHNAWs. However, the thyroid cancer rate was elevated among Arab American women compared with NHNAWs, Hispanics, and Blacks. For all sites combined, for prostate and lung cancer, Arab American men had a lower incidence than Blacks and higher incidence than Hispanics in all 3 geographic regions. Arab American male bladder cancer incidence was higher than that in Hispanics and Blacks in these regions. Conclusions. Our results suggested that further research would benefit from the federal recognition of Arab Americans as a specified ethnicity to estimate and address the cancer burden in this growing segment of the population. PMID:24825237

Incidence and survival of sebaceous carcinoma in the United States.

PubMed

Tripathi, Raghav; Chen, Zhengyi; Li, Li; Bordeaux, Jeremy S

2016-12-01

Information on risk factors, epidemiology, and clinical characteristics of sebaceous carcinoma (SC) is limited. We sought to analyze trends in SC in the United States from 2000 through 2012. We used data from the 18 registries of the Surveillance, Epidemiology, and End Results (SEER) Program from 2000 to 2012 to calculate the cause of death, relative frequencies/incidences, 5-/10-year Kaplan-Meier survival, hazard ratios, and incidence rates for SC. Each parameter was analyzed by age, location of occurrence (ocular/extraocular), race, sex, and SEER registry. Overall incidence was 0.32 (male) and 0.16 (female) per 100,000 person-years. Incidence significantly increased, primarily because of an increase among men. Incidence among whites was almost 3 times the rate among non-whites. Male sex (P < .0001), black race (P = .01), and extraocular anatomic location (P < .0001) were associated with significantly higher all-cause mortality. However, overall case-specific mortality for SC decreased significantly. Underregistration of patients in SEER registries, lack of verification of individual diagnoses, and low levels of staging data because of low stage-classification rate are limitations. The overall incidence of SC is increasing significantly. Male sex, black race, and extraocular occurrences are associated with significantly greater mortality. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Mars at 43 Million Miles From Earth

NASA Image and Video Library

2001-06-26

NASA Earth-orbiting Hubble Space Telescope took the picture on June 26, 2001 when Mars was approximately 43 million miles 68 million km from Earth -- the closest Mars has ever been to Earth since 1988.

Impact of Environmental Compliance Costs on U.S. Refining Profitability 1995-2001

EIA Publications

2003-01-01

This report assesses the effects of pollution abatement requirements on the financial performance of U.S. petroleum refining and marketing operations during the 1995 to 2001 period. This study is a follow-up to the October 1997 publication entitled The Impact of Environmental Compliance Costs on U.S. Refining Profitability, that focused on the financial impacts of U.S. refining pollution abatement investment requirements in the 1988 to1995 period.

Development, Feasibility, and Small-Scale Implementation of a Web-Based Prognostic Tool—Surveillance, Epidemiology, and End Results Cancer Survival Calculator

PubMed Central

2017-01-01

Background Population datasets and the Internet are playing an ever-growing role in the way cancer information is made available to providers, patients, and their caregivers. The Surveillance, Epidemiology, and End Results Cancer Survival Calculator (SEER*CSC) is a Web-based cancer prognostic tool that uses SEER data, a large population dataset, to provide physicians with highly valid, evidence-based prognostic estimates for increasing shared decision-making and improving patient-provider communication of complex health information. Objective The aim of this study was to develop, test, and implement SEER*CSC. Methods An iterative approach was used to develop the SEER*CSC. Based on input from cancer patient advocacy groups and physicians, an initial version of the tool was developed. Next, providers from 4 health care delivery systems were recruited to do formal usability testing of SEER*CSC. A revised version of SEER*CSC was then implemented in two health care delivery sites using a real-world clinical implementation approach, and usage data were collected. Post-implementation follow-up interviews were conducted with site champions. Finally, patients from two cancer advocacy groups participated in usability testing. Results Overall feedback of SEER*CSC from both providers and patients was positive, with providers noting that the tool was professional and reliable, and patients finding it to be informational and helpful to use when discussing their diagnosis with their provider. However, use during the small-scale implementation was low. Reasons for low usage included time to enter data, not having treatment options in the tool, and the tool not being incorporated into the electronic health record (EHR). Patients found the language in its current version to be too complex. Conclusions The implementation and usability results showed that participants were enthusiastic about the use and features of SEER*CSC, but sustained implementation in a real-world clinical setting faced significant challenges. As a result of these findings, SEER*CSC is being redesigned with more accessible language for a public facing release. Meta-tools, which put different tools in context of each other, are needed to assist in understanding the strengths and limitations of various tools and their place in the clinical decision-making pathway. The continued development and eventual release of prognostic tools should include feedback from multidisciplinary health care teams, various stakeholder groups, patients, and caregivers. PMID:28729232

Health Disparities Calculator (HD*Calc) - SEER Software

Cancer.gov

Statistical software that generates summary measures to evaluate and monitor health disparities. Users can import SEER data or other population-based health data to calculate 11 disparity measurements.

Cancer Registrar Training - SEER Registrars

Cancer.gov

View questions and answers about becoming a cancer registrar, plus training materials for cancer registration and surveillance, including SEER*Educate and information about an annual training event for advanced topics.

A prognostic index for predicting lymph node metastasis in minor salivary gland cancer.

PubMed

Lloyd, Shane; Yu, James B; Ross, Douglas A; Wilson, Lynn D; Decker, Roy H

2010-01-01

Large studies examining the clinical and pathological factors associated with nodal metastasis in minor salivary gland cancer are lacking in the literature. Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 2,667 minor salivary gland cancers with known lymph node status from 1988 to 2004. Univariate and multivariate analyses were conducted to identify factors associated with the use of neck dissection, the use of external beam radiation therapy, and the presence of cervical lymph node metastases. Four hundred twenty-six (16.0%) patients had neck nodal involvement. Factors associated with neck nodal involvement on univariate analysis included increasing age, male sex, increasing tumor size, high tumor grade, T3-T4 stage, adenocarcinoma or mucoepidermoid carcinomas, and pharyngeal site of primary malignancy. On multivariate analysis, four statistically significant factors were identified, including male sex, T3-T4 stage, pharyngeal site of primary malignancy, and high-grade adenocarcinoma or high-grade mucoepidermoid carcinomas. The proportions (and 95% confidence intervals) of patients with lymph node involvement for those with 0, 1, 2, 3, and 4 of these prognostic factors were 0.02 (0.01-0.03), 0.09 (0.07-0.11), 0.17 (0.14-0.21), 0.41 (0.33-0.49), and 0.70 (0.54-0.85), respectively. Grade was a significant predictor of metastasis for adenocarcinoma and mucoepidermoid carcinoma but not for adenoid cystic carcinoma. A prognostic index using the four clinicopathological factors listed here can effectively differentiate patients into risk groups of nodal metastasis. The precision of this index is subject to the limitations of SEER data and should be validated in further clinical studies.

Postmastectomy radiation therapy for lymph node-negative, locally advanced breast cancer after modified radical mastectomy: analysis of the NCI Surveillance, Epidemiology, and End Results database.

PubMed

Yu, James B; Wilson, Lynn D; Dasgupta, Tina; Castrucci, William A; Weidhaas, Joanne B

2008-07-01

The role of postmastectomy radiotherapy (PMRT) for lymph node-negative locally advanced breast carcinoma (T3N0M0) after modified radical mastectomy (MRM) with regard to improvement in survival remains an area of controversy. The 1973-2004 National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) database was examined for patients with T3N0M0 ductal, lobular, or mixed ductal and lobular carcinoma of the breast who underwent MRM, treated from 1988-2003. Patients who were men, who had positive lymph nodes, who survived < or =6 months, for whom breast cancer was not the first malignancy, who had nonbeam radiation, intraoperative or preoperative radiation were excluded. The average treatment effect of PMRT on mortality was estimated with a propensity score case-matched analysis. In all, 1777 patients were identified; 568 (32%) patients received PMRT. Median tumor size was 6.3 cm. The median number of lymph nodes examined was 14 (range, 1-49). Propensity score matched case-control analysis showed no improvement in overall survival with the delivery of PMRT in this group. Older patients, patients with ER- disease (compared with ER+), and patients with high-grade tumors (compared with well differentiated) had increased mortality. The use of PMRT for T3N0M0 breast carcinoma after MRM is not associated with an increase in overall survival. It was not possible to analyze local control in this study given the limitations of the SEER database. The impact of potential improvement in local control as it relates to overall survival should be the subject of further investigation. (Copyright) 2008 American Cancer Society.

Assessing the utility of cancer-registry-processed cause of death in calculating cancer-specific survival.

PubMed

Hu, Chung-Yuan; Xing, Yan; Cormier, Janice N; Chang, George J

2013-05-15

Cancer registries use algorithms to process cause of death (COD) data from death certificates, but uncertainties remain regarding the accuracy and utility of those data in calculating cancer-specific survival (CSS). Because it is impractical to reconfirm the COD through meticulous review of the primary medical records, the observed cancer deaths could be compared with the number of attributed deaths, as estimated by using a relative survival (RS) approach, to determine utility in CSS estimation. Six major cancer types were evaluated using Surveillance, Epidemiology, and End Results (SEER) data (1988-1999 cohort). The COD utility was quantified by using the observed-to-expected ratio (O/E ratio) approach, which was calculated as the SEER-documented observed number of cancer-specific deaths divided by the number of expected deaths attributed to the malignancies as estimated using a RS approach. Favorable utility would have an O/E ratio close to 1. In total, 338,445 patients were identified; and their O/E ratios were 0.97, 0.98, 0.90, 1.07, 1.02, and 0.92 for breast, colorectal, lung, melanoma, prostate, and pancreas cancer, respectively. O/E ratios varied slightly with patients' age, race, and tumor stage, but not by sex. CSS for patients with lung cancer appeared to be overestimated considerably. Patients with multiple cancer diagnoses had poor O/E ratios compared with those who had only 1 cancer. The utility of COD in calculating CSS depended variously on the risk of cancer-related mortality and nontumor factors. However, the impact of this variation on CSS generally was small. The current results indicated that the COD assigned by cancer registries has acceptable validity, and CSS is considered an acceptable surrogate for RS in most circumstances. Copyright © 2013 American Cancer Society.

Racial differences in cervical cancer survival in the Detroit metropolitan area.

PubMed

Movva, Sujana; Noone, Anne-Michelle; Banerjee, Mousumi; Patel, Divya A; Schwartz, Kendra; Yee, Cecilia L; Simon, Michael S

2008-03-15

African-American (AA) women have lower survival rates from cervical cancer compared with white women. The objective of this study was to examine the influence of socioeconomic status (SES) and other variables on racial disparities in overall survival among women with invasive cervical cancer. One thousand thirty-six women (705 white women and 331 AA women) who were diagnosed with primary invasive cancer of the cervix between 1988 and 1992 were identified through the Metropolitan Detroit Cancer Surveillance System (MDCSS), a registry in the Surveillance, Epidemiology, and End Results (SEER) database. Pathology, treatment, and survival data were obtained through SEER. SES was categorized by using occupation, poverty, and educational status at the census tract level. Cox proportional hazards models were used to compare overall survival between AA women and white women adjusting for sociodemographics, clinical presentation, and treatment. AA women were more likely to present at an older age (P<.001), with later stage disease (P<.001), and with squamous histology (P=.01), and they were more likely to reside in a census tract categorized as Working Poor (WP) (P<.001). After multivariate adjustment, race no longer had a significant impact on survival. Women who resided in a WP census tract had a higher risk of death than women from a Professional census tract (P=.05). There was a significant interaction between disease stage and time with the effect of stage on survival attenuated after 6 years. In this study, factors that affected access to medical care appeared to have a more important influence than race on the long-term survival of women with invasive cervical cancer. Copyright (c) 2008 American Cancer Society.

A Prognostic Index for Predicting Lymph Node Metastasis in Minor Salivary Gland Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lloyd, Shane; Yu, James B.; Ross, Douglas A.

2010-01-15

Purpose: Large studies examining the clinical and pathological factors associated with nodal metastasis in minor salivary gland cancer are lacking in the literature. Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 2,667 minor salivary gland cancers with known lymph node status from 1988 to 2004. Univariate and multivariate analyses were conducted to identify factors associated with the use of neck dissection, the use of external beam radiation therapy, and the presence of cervical lymph node metastases. Results: Four hundred twenty-six (16.0%) patients had neck nodal involvement. Factors associated with neck nodal involvement on univariatemore » analysis included increasing age, male sex, increasing tumor size, high tumor grade, T3-T4 stage, adenocarcinoma or mucoepidermoid carcinomas, and pharyngeal site of primary malignancy. On multivariate analysis, four statistically significant factors were identified, including male sex, T3-T4 stage, pharyngeal site of primary malignancy, and high-grade adenocarcinoma or high-grade mucoepidermoid carcinomas. The proportions (and 95% confidence intervals) of patients with lymph node involvement for those with 0, 1, 2, 3, and 4 of these prognostic factors were 0.02 (0.01-0.03), 0.09 (0.07-0.11), 0.17 (0.14-0.21), 0.41 (0.33-0.49), and 0.70 (0.54-0.85), respectively. Grade was a significant predictor of metastasis for adenocarcinoma and mucoepidermoid carcinoma but not for adenoid cystic carcinoma. Conclusions: A prognostic index using the four clinicopathological factors listed here can effectively differentiate patients into risk groups of nodal metastasis. The precision of this index is subject to the limitations of SEER data and should be validated in further clinical studies.« less

Validated Competing Event Model for the Stage I-II Endometrial Cancer Population

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carmona, Ruben; Gulaya, Sachin; Murphy, James D.

2014-07-15

Purpose/Objectives(s): Early-stage endometrial cancer patients are at higher risk of noncancer mortality than of cancer mortality. Competing event models incorporating comorbidity could help identify women most likely to benefit from treatment intensification. Methods and Materials: 67,397 women with stage I-II endometrioid adenocarcinoma after total hysterectomy diagnosed from 1988 to 2009 were identified in Surveillance, Epidemiology, and End Results (SEER) and linked SEER-Medicare databases. Using demographic and clinical information, including comorbidity, we sought to develop and validate a risk score to predict the incidence of competing mortality. Results: In the validation cohort, increasing competing mortality risk score was associated with increasedmore » risk of noncancer mortality (subdistribution hazard ratio [SDHR], 1.92; 95% confidence interval [CI], 1.60-2.30) and decreased risk of endometrial cancer mortality (SDHR, 0.61; 95% CI, 0.55-0.78). Controlling for other variables, Charlson Comorbidity Index (CCI) = 1 (SDHR, 1.62; 95% CI, 1.45-1.82) and CCI >1 (SDHR, 3.31; 95% CI, 2.74-4.01) were associated with increased risk of noncancer mortality. The 10-year cumulative incidences of competing mortality within low-, medium-, and high-risk strata were 27.3% (95% CI, 25.2%-29.4%), 34.6% (95% CI, 32.5%-36.7%), and 50.3% (95% CI, 48.2%-52.6%), respectively. With increasing competing mortality risk score, we observed a significant decline in omega (ω), indicating a diminishing likelihood of benefit from treatment intensification. Conclusion: Comorbidity and other factors influence the risk of competing mortality among patients with early-stage endometrial cancer. Competing event models could improve our ability to identify patients likely to benefit from treatment intensification.« less

Annual Statistical Report, 1988. Client Assistance Program, Protection & Advocacy System for Persons with Mental Illness, Protection & Advocacy System for Persons with Developmental Disabilities.

ERIC Educational Resources Information Center

National Association of Protection and Advocacy Systems, Washington, DC.

The report summarizes: (1) 1988 program data for state Protection and Advocacy Systems for persons with developmental disabilities and persons with mental illness, and (2) 1988 program data for Client Assistance Programs. The data are derived from reports from 56 states and territories. In addition to nationwide data totals, each state's…

Inaccuracies in oral cavity-pharynx cancer coded as the underlying cause of death on U.S. death certificates, and trends in mortality rates (1999-2010).

PubMed

Polednak, Anthony P

2014-08-01

To enhance surveillance of mortality from oral cavity-pharynx cancer (OCPC) by considering inaccuracies in the cancer site coded as the underlying cause of death on death certificates vs. cancer site in a population-based cancer registry (as the gold standard). A database was used for 9 population-based cancer registries of the Surveillance, Epidemiology and End Results (SEER) Program, including deaths in 1999-2010 for patients diagnosed in 1973-2010. Numbers of deaths and death rates for OCPC in the SEER population were modified for apparent inaccuracies in the cancer site coded as the underlying cause of death. For age groups <65 years, deaths from OCPC were underestimated by 22-35% by using unmodified (vs. modified) numbers, but temporal declines in death rates were still evident in the SEER population and were similar to declines using routine mortality data for the entire U.S. population. Deaths were underestimated by about 70-80% using underlying cause for tonsillar cancers, strongly associated with human papillomavirus (HPV) infection, but a lack of decline in death rates was still evident. Routine mortality statistics based on underlying cause of death underestimate OCPC deaths but demonstrate trends in OCPC death rates that require continued surveillance in view of increasing incidence rates for HPV-related OCPC. Copyright © 2014 Elsevier Ltd. All rights reserved.

Trends in atmospheric ammonium concentrations in relation to atmospheric sulfate and local agriculture.

PubMed

Kelly, Victoria R; Lovett, Gary M; Weathers, Kathleen C; Likens, Gene E

2005-06-01

Ammonium (NH(4)(+)) concentrations in air and precipitation at the Institute of Ecosystem Studies (IES) in southeastern New York, USA declined over an 11-year period from 1988 to 1999, but increased from 1999 to 2001. These trends in particulate NH(4)(+) correlated well with trends in particulate SO(4)(2-) over the 1988-2001 period. The NH(4)(+) trends were not as well correlated with local cattle and milk production, which declined continuously throughout the period. This suggests that regional transport of SO(4)(2-) may have a greater impact on concentrations of NH(4)(+) and subsequent deposition than local agricultural emissions of NH(3). Ammonium concentrations in precipitation correlated significantly with precipitation SO(4)(2-) concentrations for the 1984-2001 period although NH(4)(+) in precipitation increased after 1999 and SO(4)(2-) in precipitation continued to decline after 1999. The correlation between NH(4)(+) and SO(4)(2-) was stronger for particulates than for precipitation. Particulate NH(4)(+) concentrations were also correlated with particulate SO(4)(2-) concentrations at 31 of 35 eastern U.S. CASTNet sites that had at least 10 years of data. Air concentrations of NH(4)(+) and SO(4)(2-) were more strongly correlated at the sites that were located within an agricultural landscape than in forested sites. At most of the sites there was either no trend or a decrease in NH(4)(+) dry deposition during the 1988-2001 period. The sites that showed an increasing trend in NH(4)(+) dry deposition were generally located in the southeastern U.S. The results of this study suggest that, in the northeastern U.S., air concentrations of NH(4)(+) and subsequent deposition may be more closely linked to SO(4)(2-) and thus SO(2) emissions than with NH(3) emissions. These results also suggest that reductions in S emissions have reduced NH(4)(+) transport to and NH(4)(+)-N deposition in the Northeast.

Software Used to Generate Cancer Statistics - SEER Cancer Statistics

Cancer.gov

Videos that highlight topics and trends in cancer statistics and definitions of statistical terms. Also software tools for analyzing and reporting cancer statistics, which are used to compile SEER's annual reports.

Breast-cancer-specific mortality in patients treated based on the 21-gene assay: a SEER population-based study.

PubMed

Petkov, Valentina I; Miller, Dave P; Howlader, Nadia; Gliner, Nathan; Howe, Will; Schussler, Nicola; Cronin, Kathleen; Baehner, Frederick L; Cress, Rosemary; Deapen, Dennis; Glaser, Sally L; Hernandez, Brenda Y; Lynch, Charles F; Mueller, Lloyd; Schwartz, Ann G; Schwartz, Stephen M; Stroup, Antoinette; Sweeney, Carol; Tucker, Thomas C; Ward, Kevin C; Wiggins, Charles; Wu, Xiao-Cheng; Penberthy, Lynne; Shak, Steven

2016-01-01

The 21-gene Recurrence Score assay is validated to predict recurrence risk and chemotherapy benefit in hormone-receptor-positive (HR+) invasive breast cancer. To determine prospective breast-cancer-specific mortality (BCSM) outcomes by baseline Recurrence Score results and clinical covariates, the National Cancer Institute collaborated with Genomic Health and 14 population-based registries in the the Surveillance, Epidemiology, and End Results (SEER) Program to electronically supplement cancer surveillance data with Recurrence Score results. The prespecified primary analysis cohort was 40-84 years of age, and had node-negative, HR+, HER2-negative, nonmetastatic disease diagnosed between January 2004 and December 2011 in the entire SEER population, and Recurrence Score results ( N =38,568). Unadjusted 5-year BCSM were 0.4% ( n =21,023; 95% confidence interval (CI), 0.3-0.6%), 1.4% ( n =14,494; 95% CI, 1.1-1.7%), and 4.4% ( n =3,051; 95% CI, 3.4-5.6%) for Recurrence Score <18, 18-30, and ⩾31 groups, respectively ( P <0.001). In multivariable analysis adjusted for age, tumor size, grade, and race, the Recurrence Score result predicted BCSM ( P <0.001). Among patients with node-positive disease (micrometastases and up to three positive nodes; N =4,691), 5-year BCSM (unadjusted) was 1.0% ( n =2,694; 95% CI, 0.5-2.0%), 2.3% ( n =1,669; 95% CI, 1.3-4.1%), and 14.3% ( n =328; 95% CI, 8.4-23.8%) for Recurrence Score <18, 18-30, ⩾31 groups, respectively ( P <0.001). Five-year BCSM by Recurrence Score group are reported for important patient subgroups, including age, race, tumor size, grade, and socioeconomic status. This SEER study represents the largest report of prospective BCSM outcomes based on Recurrence Score results for patients with HR+, HER2-negative, node-negative, or node-positive breast cancer, including subgroups often under-represented in clinical trials.

SEER*Explorer

Cancer.gov

This interactive website provides access to cancer statistics (rates and trends) for a cancer site by gender, race, calendar year, stage, and histology. Users can create custom graphs and tables, download data and images, download SEER*Stat sessions, and share results.

Standard Populations (Millions) for Age-Adjustment - SEER Population Datasets

Cancer.gov

Download files containing standard population data for use in statististical software. The files contain the same data distributed with SEER*Stat software. You can also view the standard populations, either 19 age groups or single ages.

New Opportunities for Cancer Health Services Research: Linking the SEER-Medicare Data to the Nursing Home Minimum Data Set.

PubMed

Thomas, Kali S; Boyd, Eric; Mariotto, Angela B; Penn, Dolly C; Barrett, Michael J; Warren, Joan L

2018-02-02

The Surveillance, Epidemiology and End Results (SEER)-Medicare data combine clinical information from population-based cancer registries with Medicare claims. These data have been used in many studies to understand cancer screening, treatment, outcomes, and costs. However, until recently, these data included limited information related to the characteristics and outcomes of cancer patients residing in or admitted to nursing homes. To provide an overview of the new linkage between SEER-Medicare data and the Minimum Data Set (MDS), a nursing home resident assessment instrument detailing residents' physical, psychological, and psychosocial functioning as well as any therapies or treatments received. This is a descriptive, retrospective cohort study. Persons in SEER-Medicare diagnosed with cancer from 2004 to 2013 were linked to the 2011-2014 MDS, with 17% of SEER-Medicare patients linked to the MDS data. During 2011-2014, we identified 318,617 cancer patients receiving care in a nursing home and 256,947 cancer patients newly admitted to a total of 10,953 nursing homes. Of these patients, approximately two thirds were Medicare fee-for-service beneficiaries. The timing from cancer diagnoses to nursing home admission varied by cancer. In total, 93% of all patients were admitted directly to a nursing home from an acute care hospital. The majority of patients were cognitively intact, 21% reported some level of depression, and 9% had severe functional limitations. The new SEER-Medicare-MDS dataset provides a valuable resource for understanding the postacute and long-term care experiences of cancer patients receiving care in United States' nursing homes.

Improved Survival With Radiation Therapy in Stage I-II Primary Mediastinal B Cell Lymphoma: A Surveillance, Epidemiology, and End Results Database Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackson, Matthew W., E-mail: matthew.jackson@ucdenver.edu; Rusthoven, Chad G.; Jones, Bernard L.

Background: Primary mediastinal B cell lymphoma (PMBCL) is an uncommon lymphoma for which trials are few with small patient numbers. The role of radiation therapy (RT) after standard immunochemotherapy for early-stage disease has never been studied prospectively. We used the Surveillance, Epidemiology, and End Results (SEER) database to evaluate PMBCL and the impact of RT on outcomes. Methods and Materials: We queried the SEER database for patients with stage I-II PMBCL diagnosed from 2001 to 2011. Retrievable data included age, gender, race (white/nonwhite), stage, extranodal disease, year of diagnosis, and use of RT as a component of definitive therapy. Kaplan-Meier overallmore » survival (OS) estimates, univariate (UVA) log-rank and multivariate (MVA) Cox proportional hazards regression analyses were performed. Results: Two hundred fifty patients with stage I-II disease were identified, with a median follow-up time of 39 months (range, 3-125 months). The median age was 36 years (range, 18-89 years); 61% were female; 76% were white; 45% had stage I disease, 60% had extranodal disease, and 55% were given RT. The 5-year OS for the entire cohort was 86%. On UVA, OS was improved with RT (hazard ratio [HR] 0.446, P=.029) and decreased in association with nonwhite race (HR 2.70, P=.006). The 5-year OS was 79% (no RT) and 90% (RT). On MVA, white race and RT remained significantly associated with improved OS (P=.007 and .018, respectively). The use of RT decreased over time: 61% for the 67 patients whose disease was diagnosed from 2001 to 2005 and 53% in the 138 patients treated from 2006 to 2010. Conclusion: This retrospective population-based analysis is the largest PMBCL dataset to date and demonstrates a significant survival benefit associated with RT. Nearly half of patients treated in the United States do not receive RT, and its use appears to be declining. In the absence of phase 3 data, the use of RT should be strongly considered for its survival benefit in early-stage disease.« less

Structures and Dynamics Division research and technology plans for FY 1988 and accomplishments for FY 1987

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1988-01-01

Presented are the Objectives, FY 1988 Plans, Approach, and FY 1988 Milestones for the Structures and Dynamics Division (Langley Research Center) research programs. FY 1987 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Secular trends in fruit intake among Danish schoolchildren, 1988 to 2006: Changing habits or methodological artefacts?

PubMed Central

Rasmussen, Mette; Krølner, Rikke; Svastisalee, Chalida Mae; Due, Pernille; Holstein, Bjørn Evald

2008-01-01

Background Intermittent monitoring of fruit and vegetable intake at the population level is essential for the evaluation and planning of national dietary interventions. Yet, only a limited number of studies on time trends in fruit and vegetable intake among children and adolescents have been published internationally. In Denmark, national comprehensive campaigns to enhance fruit and vegetable consumption were initiated in 2001. This paper describes secular trends in fruit intake among Danish adolescents by six comparable school surveys from 1988 to 2006. The paper demonstrates and discusses the consequences of measurement changes introduced in long-term trend analyses. Methods We used Danish data from the international Health Behaviour in School-aged Children (HBSC) study collected in 1988, 1991, 1994, 1998, 2002 and 2006. Analyses were conducted on comparable questionnaire-based data from students aged 11, 13 and 15 total (n = 23,871) from a random sample of schools. Data on fruit intake were measured by a food frequency questionnaire. Due to changes in number of response categories beween surveys, different cut-points were analysed. Results The prevalence of students eating fruit at least once daily ranged from 78.3% among 13-year-old girls in 1988 to 17.3% among 15-year-old boys in 2002. Based on the six data collections, analyses of trends showed a significant decrease in prevalence of students eating fruit at least once daily from 1988 to 2002 (all p-values < 0.0001). In all age and gender groups, a significant increase in intake occurred between 2002 and 2006 (all p-values < 0.0065). Analyses of alternative cut-points revealed similar results. Conclusion Fruit consumption among Danish schoolchildren decreased from 1988 to 2002 with an increase since 2002. We suggest that the increase may be attributable to a nation-wide initiative conducted in Denmark since 2001 to increase the intake of fruit and vegetables in the population. Still, the results imply that a substantial proportion of Danish schoolchildren do not meet the nationally recommended daily intake of fruit. Our analyses indicate that the observed trends are not solely caused by methodological biases related to changes in measurements. PMID:18237390

MindSeer: a portable and extensible tool for visualization of structural and functional neuroimaging data

PubMed Central

Moore, Eider B; Poliakov, Andrew V; Lincoln, Peter; Brinkley, James F

2007-01-01

Background Three-dimensional (3-D) visualization of multimodality neuroimaging data provides a powerful technique for viewing the relationship between structure and function. A number of applications are available that include some aspect of 3-D visualization, including both free and commercial products. These applications range from highly specific programs for a single modality, to general purpose toolkits that include many image processing functions in addition to visualization. However, few if any of these combine both stand-alone and remote multi-modality visualization in an open source, portable and extensible tool that is easy to install and use, yet can be included as a component of a larger information system. Results We have developed a new open source multimodality 3-D visualization application, called MindSeer, that has these features: integrated and interactive 3-D volume and surface visualization, Java and Java3D for true cross-platform portability, one-click installation and startup, integrated data management to help organize large studies, extensibility through plugins, transparent remote visualization, and the ability to be integrated into larger information management systems. We describe the design and implementation of the system, as well as several case studies that demonstrate its utility. These case studies are available as tutorials or demos on the associated website: . Conclusion MindSeer provides a powerful visualization tool for multimodality neuroimaging data. Its architecture and unique features also allow it to be extended into other visualization domains within biomedicine. PMID:17937818

Basinsoft, a computer program to quantify drainage basin characteristics

USGS Publications Warehouse

Harvey, Craig A.; Eash, David A.

2001-01-01

In 1988, the USGS began developing a program called Basinsoft. The initial program quantified 16 selected drainage basin characteristics from three source-data layers that were manually digitized from topographic maps using the versions of ARC/INFO, Fortran programs, and prime system Command Programming Language (CPL) programs available in 1988 (Majure and Soenksen, 1991). By 1991, Basinsoft was enhanced to quantify 27 selected drainage-basin characteristics from three source-data layers automatically generated from digital elevation model (DEM) data using a set of Fortran programs (Majure and Eash, 1991: Jenson and Dominique, 1988). Due to edge-matching problems encountered in 1991 with the preprocessing

Summary Stage 2018 - SEER

Cancer.gov

Access this manual of codes and coding instructions for the summary stage field for cases diagnosed January 1, 2018 and forward. 2018 version applies to every site and/or histology combination, including lymphomas and leukemias. Historically, also called General Staging, California Staging, and SEER Staging.

Risk of cardiac death among cancer survivors in the United States: a SEER database analysis.

PubMed

Abdel-Rahman, Omar

2017-09-01

Population-based data on the risk of cardiac death among cancer survivors are needed. This scenario was evaluated in cancer survivors (>5 years) registered within the Surveillance, Epidemiology and End Results (SEER) database. The SEER database was queried using SEER*Stat to determine the frequency of cardiac death compared to other causes of death; and to determine heart disease-specific and cancer-specific survival rates in survivors of each of the 10 most common cancers in men and women in the SEER database. For cancer-specific survival rate, the highest rates were related to thyroid cancer survivors; while the lowest rates were related to lung cancer survivors. For heart disease-specific survival rate, the highest rates were related to thyroid cancer survivors; while the lowest rates were related to both lung cancer survivors and urinary bladder cancer survivors. The following factors were associated with a higher likelihood of cardiac death: male gender, old age at diagnosis, black race and local treatment with radiotherapy rather than surgery (P < 0.0001 for all parameters). Among cancer survivors (>5 years), cardiac death is a significant cause of death and there is a wide variability among different cancers in the relative importance of cardiac death vs. cancer-related death.

Calibration and Validation of the COCOMO II.1997.0 Cost/Schedule Estimating Model to the Space and Missile Systems Center Database

DTIC Science & Technology

1997-09-01

Daly chose five models (REVIC, PRICE-S, SEER, System-4, and SPQR /20) to estimate schedule for 21 separate projects from the Electronic System Division...PRICE-S, two variants of COCOMO, System-3, SPQR /20, SASET, SoftCost-Ada) to 11 eight Ada specific programs. Ada was specifically designed for and is

DOE Office of Scientific and Technical Information (OSTI.GOV)

Apte, Michael G.; Norman, Bourassa; Faulkner, David

An improved HVAC system for portable classrooms was specified to address key problems in existing units. These included low energy efficiency, poor control of and provision for adequate ventilation, and excessive acoustic noise. Working with industry, a prototype improved heat pump air conditioner was developed to meet the specification. A one-year measurement-intensive field-test of ten of these IHPAC systems was conducted in occupied classrooms in two distinct California climates. These measurements are compared to those made in parallel in side by side portable classrooms equipped with standard 10 SEER heat pump air conditioner equipment. The IHPAC units were found tomore » work as designed, providing predicted annual energy efficiency improvements of about 36 percent to 42 percent across California's climate zones, relative to 10 SEER units. Classroom ventilation was vastly improved as evidenced by far lower indoor minus outdoor CO2 concentrations. TheIHPAC units were found to provide ventilation that meets both California State energy and occupational codes and the ASHRAE minimum ventilation requirements; the classrooms equipped with the 10 SEER equipment universally did not meet these targets. The IHPAC system provided a major improvement in indoor acoustic conditions. HVAC system generated background noise was reduced in fan-only and fan and compressor modes, reducing the nose levels to better than the design objective of 45 dB(A), and acceptable for additional design points by the Collaborative on High Performance Schools. The IHPAC provided superior ventilation, with indoor minus outdoor CO2 concentrations that showed that the Title 24 minimum ventilation requirement of 15 CFM per occupant was nearly always being met. The opposite was found in the classrooms utilizing the 10 SEER system, where the indoor minus outdoor CO2 concentrations frequently exceeded levels that reflect inadequate ventilation. Improved ventilation conditions in the IHPAC lead to effective removal of volatile organic compounds and aldehydes, on average lowering the concentrations by 57 percent relative to the levels in the 10 SEER classrooms. The average IHPAC to 10 SEER formaldehyde ratio was about 67 percent, indicating only a 33 percent reduction of this compound in indoor air. The IHPAC thermal control system provided less variability in occupied classroom temperature than the 10 SEER thermostats. The average room temperatures in all seasons tended to be slightly lower in the IHPAC classrooms, often below the lower limit of the ASHRAE 55 thermal comfort band. State-wide and national energy modeling provided conservative estimates of potential energy savings by use of the IHPAC system that would provide payback a the range of time far lower than the lifetime of the equipment. Assuming electricity costs of $0.15/kWh, the perclassroom range of savings is from about $85 to $195 per year in California, and about $89 to $250 per year in the U.S., depending upon the city. These modelsdid not include the non-energy benefits to the classrooms including better air quality and acoustic conditions that could lead to improved health and learning in school. Market connection efforts that were part of the study give all indication that this has been a very successful project. The successes include the specification of the IHPAC equipment in the CHPS portable classroom standards, the release of a commercial product based on the standards that is now being installed in schools around the U.S., and the fact that a public utility company is currently considering the addition of the technology to its customer incentive program. These successes indicate that the IHPAC may reach its potential to improve ventilation and save energy in classrooms.« less

Short-term predictions in forex trading

NASA Astrophysics Data System (ADS)

Muriel, A.

2004-12-01

Using a kinetic equation that is used to model turbulence (Physica A, 1985-1988, Physica D, 2001-2003), we redefine variables to model the time evolution of the foreign exchange rates of three major currencies. We display live and predicted data for one period of trading in October, 2003.

The Nature of Imagination in Education for Sustainability

ERIC Educational Resources Information Center

Jensen, Sally

2015-01-01

The importance of imagination in education has a significant history (Egan, 1986, 2001; Eisner, 1976; Greene, 1988; Steiner, 1954; Warnock, 1976); however, scholarship is often theoretical, and the involvement of imagination in understanding sustainability is often overlooked (Jones, 1995; Judson, 2010; Stewart, 2009). Imagination has rarely been…

49 CFR 171.7 - Reference material.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Equipped Freight Car and Intermodal Equipment, 1988 174.55; 174.63. AAR Specifications for Design... Pamphlet C-8, Standard for Requalification of DOT-3HT Cylinder Design, 1985 180.205; 180.209. CGA Pamphlet C-11, Recommended Practices for Inspection of Compressed Gas Cylinders at Time of Manufacture, 2001...

49 CFR 171.7 - Reference material.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Car and Intermodal Equipment, 1988 174.55; 174.63. AAR Specifications for Design, Fabrication and... Pamphlet C-8, Standard for Requalification of DOT-3HT Cylinder Design, 1985 180.205; 180.209. CGA Pamphlet C-11, Recommended Practices for Inspection of Compressed Gas Cylinders at Time of Manufacture, 2001...

Cancer Survival in California Hispanic Farmworkers, 1988-2001

ERIC Educational Resources Information Center

Dodge, Jennifer L.; Mills, Paul K.; Riordan, Deborah G.

2007-01-01

Context: Although epidemiologic studies have identified elevated cancer risk in farmworkers for some cancer types, little is known about cancer survival in this population. Purpose: To determine if cancer survival differs between a Hispanic farmworker population and the general Hispanic population in California. Methods: Hispanic United Farm…

Results of the 1988 NASA/JPL balloon flight solar cell calibration program

NASA Technical Reports Server (NTRS)

Anspaugh, B. E.; Weiss, R. S.

1988-01-01

The 1988 solar cell calibration balloon flight was successfully completed on August 7, 1988, meeting all objectives of the program. Forty-eight modules were carried to an altitude of 118,000 ft (36.0 km). The calibrated cells can now be used as reference standards in simulator testing of cells and arrays.

77 FR 39748 - Computer Matching and Privacy Protection Act of 1988; Report of Matching Program: RRB and State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-05

... RAILROAD RETIREMENT BOARD Computer Matching and Privacy Protection Act of 1988; Report of Matching.... General The Computer Matching and Privacy Protection Act of 1988 (Pub. L. 100-503), amended the Privacy... of an existing computer matching program due to expire on August 12, 2012. SUMMARY: The Privacy Act...

Characteristics and Outcomes of Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma Versus Those With Classical Hodgkin Lymphoma: A Population-Based Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerber, Naamit K.; Atoria, Coral L.; Elkin, Elena B.

Purpose: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is rare, comprising approximately 5% of all Hodgkin lymphoma (HL) cases. Patients with NLPHL tend to have better prognoses than those with classical HL (CHL). Our goal was to assess differences in survival between NLPHL and CHL patients, controlling for differences in patient and disease characteristics. Methods and Materials: Using data from the population-based Surveillance, Epidemiology and End Results (SEER) cancer registry program, we identified patients diagnosed with pathologically confirmed HL between 1988 and 2010. Results: We identified 1,162 patients with NLPHL and 29,083 patients with CHL. With a median follow-up of 7 years, 5- andmore » 10-year overall survival (OS) rates were 91% and 83% for NLPHL, respectively, and 81% and 74% for CHL, respectively. After adjusting for all available characteristics, NLPHL (vs CHL) was associated with higher OS (hazard ratio [HR]: 0.62, P<.01) and disease-specific survival (DSS; HR: 0.48, P<.01). The male predominance of NLPHL, compared to CHL, as well as the more favorable prognostic features in NLPHL patients are most pronounced in NLPHL patients <20 years old. Among all NLPHL patients, younger patients were less likely to receive radiation, and radiation use has declined by 40% for all patients from 1988 to 2010. Receipt of radiation was associated with better OS (HR: 0.64, P=.03) and DSS (HR: 0.45, P=.01) in NLPHL patients after controlling for available baseline characteristics. Other factors associated with OS and DSS in NLPHL patients are younger age and early stage. Conclusions: Our results in a large population dataset demonstrated that NLPHL patients have improved prognosis compared to CHL patients, even after accounting for stage and baseline characteristics. Use of radiation is declining among NLPHL patients despite an association in this series between radiation and better DSS and OS. Unique treatment strategies for NLPHL are warranted in both early and advanced stage disease.« less

Survival Analyses and Prognosis of Plasma Cell Myeloma and Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorders

PubMed Central

Rosenberg, Aaron S.; Ruthazer, Robin; Paulus, Jessica K.; Kent, David M.; Evens, Andrew M.; Klein, Andreas K.

2016-01-01

Background Multiple myeloma/plasmacytoma-like post-transplant lymphoproliferative disorder (PTLD-MM) is a rare complication of solid organ transplant. Case series have shown variable outcomes and survival data in the modern era are lacking. Methods A cohort of 212 PTLD-MM patients was identified in the Scientific Registry of Transplant Recipients between 1999-2011. Overall survival (OS) was estimated using the Kaplan-Meier method and the effects of treatment and patient characteristics on OS evaluated with Cox proportional hazards models. OS in 185 PTLD-MM patients was compared with 4048 matched controls with multiple myeloma (SEER-MM) derived from SEER. Results Men comprised 71% of patients; extramedullary disease was noted in 58%. Novel therapeutic agents were used in 19% of patients (more commonly 2007-2011 versus 1999-2006 (P=0.01)), reduced immunosuppression in 55%, and chemotherapy in 32%. Median OS was 2.4 years, and improved in the later time period (aHR 0.64, P=0.05). Advanced age, creatinine>2, Caucasian race and use of OKT3 were associated with inferior OS in multivariable analysis. OS of PTLD-MM is significantly inferior to SEER-MM patients (aHR 1.6, p<0.001). Improvements in OS over time differed between PTLD-MM and SEER-MM. Median OS of patients diagnosed 2000-2005 was shorter for PTLD-MM than SEER-MM patients (18 vs 47 months P<0.001). There was no difference among those diagnosed 2006-2010 (44 mo vs median not reached P=0.5) (interaction P=0.08). Conclusions Age at diagnosis, elevated creatinine, Caucasian race and OKT3 were associated with inferior survival in patients with PTLD-MM. Survival of PTLD-MM is inferior to SEER-MM, though significant improvements in survival have been documented. PMID:27771291

The health care experience of patients with cancer during the last year of life: Analysis of the SEER-CAHPS data set.

PubMed

Halpern, Michael T; Urato, Matthew P; Kent, Erin E

2017-01-01

Providing high-quality medical care for individuals with cancer during their last year of life involves a range of challenges. An important component of high-quality care during this critical period is ensuring optimal patient satisfaction. The objective of the current study was to assess factors influencing health care ratings among individuals with cancer within 1 year before death. The current study used the Surveillance, Epidemiology, and End Results (SEER)-Consumer Assessment of Healthcare Providers and Systems (CAHPS) data set, a new data resource linking patient-reported information from the CAHPS Medicare Survey with clinical information from the National Cancer Institute's SEER program. The study included 5102 Medicare beneficiaries diagnosed with cancer who completed CAHPS between 1998 and 2011 within 1 year before their death. Multivariable logistic regression analyses examined associations between patient demographic and insurance characteristics with 9 measures of health care experience. Patients with higher general or mental health status were significantly more likely to indicate excellent experience with nearly all measures examined. Sex, race/ethnicity, and education also were found to be significant predictors for certain ratings. Greater time before death predicted an increased likelihood of higher ratings for health plan and specialist physician. Clinical characteristics were found to have few significant associations with experience of care. Individuals in fee-for-service Medicare plans (vs Medicare Advantage) had a greater likelihood of excellent experience with health plans, getting care quickly, and getting needed care. Among patients with cancer within 1 year before death, experience with health plans, physicians, and medical care were found to be associated with sociodemographic, insurance, and clinical characteristics. These findings provide guidance for the development of programs to improve the experience of care among individuals with cancer. Cancer 2017;123:336-344. © 2016 American Cancer Society. © 2016 American Cancer Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Analysis of Stage and Clinical/Prognostic Factors for Lung Cancer from SEER Registries: AJCC Staging and Collaborative Stage Data Collection System

PubMed Central

Chen, Vivien W.; Ruiz, Bernardo A.; Hsieh, Mei-Chin; Wu, Xiao-Cheng; Ries, Lynn; Lewis, Denise R.

2014-01-01

Introduction The American Joint Committee on Cancer (AJCC) 7th edition introduced major changes in the staging of lung cancer, including Tumor (T), Node (N), Metastasis (M) (TNM) system and new stage/prognostic site-specific factors (SSFs), collected under the Collaborative Stage Version 2 (CSv2) Data Collection System. The intent was to improve the stage precision which could guide treatment options and ultimately lead to better survival. This report examines stage trends, the change in stage distributions from the AJCC 6th to the 7th edition, and findings of the prognostic SSFs for 2010 lung cancer cases. Methods Data were from the November 2012 submission of 18 Surveillance, Epidemiology, and End Results (SEER) Program population-based registries. A total of 344 797 cases of lung cancer, diagnosed in 2004–2010, were analyzed. Results The percentages of small tumors and early stage lung cancer cases increased from 2004 to 2010. The AJCC 7th edition, implemented for 2010 diagnosis year, subclassified tumor size and reclassified multiple tumor nodules, pleural effusions, and involvement of tumors in the contralateral lung, resulting in a slight decrease in stage IB and stage IIIB and a small increase in stage IIA and stage IV. Overall about 80% of cases remained the same stage group in AJCC 6th and 7th editions. About 21% of lung cancer patients had separate tumor nodules in the ipsilateral (same) lung, and 23% of the surgically resected patients had visceral pleural invasion, both adverse prognostic factors. Conclusion It is feasible for high quality population-based registries such as the SEER Program to collect more refined staging and prognostic SSFs that allows better categorization of lung cancer patients with different clinical outcomes and to assess their survival. PMID:25412390

Provider-Based Research Networks Demonstrate Greater Hospice Use for Minority Patients With Lung Cancer

PubMed Central

Penn, Dolly C.; Stitzenberg, Karyn B.; Cobran, Ewan K.; Godley, Paul A.

2014-01-01

Purpose: The Community Clinical Oncology Program (CCOP) and Minority-Based Community Clinical Oncology Program (MBCCOP) are provider-based research networks (PBRN) that improve minority enrollment in cancer-focused clinical trials. We hypothesized that affiliation with a PBRN may also mitigate racial differences in hospice enrollment for patients with lung cancer. Methods: We used the SEER-Medicare data, linked to the National Cancer Institute's CCOP program data, to identify all patients (≥ age 65 years) with lung cancer, diagnosed from 2001 to 2007. We defined clinical treatment settings as CCOP, MBCCOP, academic, or community-affiliated and used multivariable logistic regression analysis to determine factors associated with hospice enrollment. Results: Forty-one thousand eight hundred eighty-five (55.1%) patients with lung cancer enrolled in hospice before death. Approximately 55% of CCOP, 57% of MBCCOP, 57% of academic, and 52% of community patients enrolled. Patients who were more likely to enroll were female (odds ratio [OR], 1.36; 95% CI, 1.31 to 1.40); ≥ age 79 years (OR, 1.11; 95%CI, 1.06 to 1.16); white; lived in more educated areas; had minimal comorbidities; and had distant disease. Asian and black patients in academic (41.1% and 50.4%, respectively) and community practices (35.2% and 43.4%, respectively) were less likely to enroll in hospice compared with white patients (academic, 58.8%; community, 53.1%). However, hospice enrollment was equivalent for black and white patients in MBCCOP (59.5% v 57.2%) and CCOP (52.2% v 56.3%) practices. Conclusion: Minority patients with lung cancer receiving treatment in cancer-focused PBRN- affiliated practices have greater hospice enrollment than those treated in academic and community practices. PMID:24781367

OpinionSeer: interactive visualization of hotel customer feedback.

PubMed

Wu, Yingcai; Wei, Furu; Liu, Shixia; Au, Norman; Cui, Weiwei; Zhou, Hong; Qu, Huamin

2010-01-01

The rapid development of Web technology has resulted in an increasing number of hotel customers sharing their opinions on the hotel services. Effective visual analysis of online customer opinions is needed, as it has a significant impact on building a successful business. In this paper, we present OpinionSeer, an interactive visualization system that could visually analyze a large collection of online hotel customer reviews. The system is built on a new visualization-centric opinion mining technique that considers uncertainty for faithfully modeling and analyzing customer opinions. A new visual representation is developed to convey customer opinions by augmenting well-established scatterplots and radial visualization. To provide multiple-level exploration, we introduce subjective logic to handle and organize subjective opinions with degrees of uncertainty. Several case studies illustrate the effectiveness and usefulness of OpinionSeer on analyzing relationships among multiple data dimensions and comparing opinions of different groups. Aside from data on hotel customer feedback, OpinionSeer could also be applied to visually analyze customer opinions on other products or services.

Use of External Beam Radiotherapy Is Associated With Reduced Incidence of Second Primary Head and Neck Cancer: A SEER Database Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rusthoven, Kyle; Chen Changhu; Raben, David

2008-05-01

Purpose: Patients with head and neck cancer have a significant risk of developing a second primary cancer of the head and neck. We hypothesized that treatment with external beam radiotherapy (RT) might reduce this risk, because RT can eradicate occult foci of second head and neck cancer (HNCA). Methods and Materials: The data of patients with Surveillance, Epidemiology, and End Results Historic Stage A localized squamous cell carcinoma of the oral cavity, larynx, and pharynx were queried using the Surveillance, Epidemiology, and End Results database. For patients treated with or without RT, the incidence of second HNCA was determined andmore » compared using the log-rank method. Cox proportional hazards analysis was performed for each site, evaluating the influence of covariates on the risk of second HNCA. Results: Between 1973 and 1997, 27,985 patients were entered with localized HNCA. Of these patients, 44% had received RT and 56% had not. The 15-year incidence of second HNCA was 7.7% with RT vs. 10.5% without RT (hazard ratio 0.71, p <0.0001). The effect of RT was more profound in patients diagnosed between 1988 and 1997 (hazard ratio 0.53, p <0.0001) and those with pharynx primaries (hazard ratio 0.47, p <0.0001). On multivariate analysis, RT was associated with a reduced risk of second HNCA for pharynx (p <0.0001) and larynx (p = 0.04) tumors. For oral cavity primaries, RT was associated with an increased risk of second HNCA in patients treated before 1988 (p <0.001), but had no influence on patients treated between 1988 and 1997 (p = 0.91). Conclusion: For localized HNCA, RT is associated with a reduced incidence of second HNCA. These observations are consistent with the eradication of microscopic foci of second HNCA with external beam RT.« less

METRO Achievement Program: Summer 1988. External Evaluation Report.

ERIC Educational Resources Information Center

Thompson, Denise R.

This document comprises an evaluation of the 1988 METRO Achievement Program, a summer educational program to help develop the academic potential of primarily Black and Hispanic girls entering the seventh and eighth grades in Chicago. The 5-week program included the following components: (1) mathematics, science, and communication skills classes;…

40 CFR 52.1988 - Air contaminant discharge permits.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 4 2013-07-01 2013-07-01 false Air contaminant discharge permits. 52.1988 Section 52.1988 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Oregon § 52.1988 Air contaminant...

Area-level variations in cancer care and outcomes.

PubMed

Keating, Nancy L; Landrum, Mary Beth; Lamont, Elizabeth B; Bozeman, Samuel R; McNeil, Barbara J

2012-05-01

: Substantial regional variations in health-care spending exist across the United States; yet, care and outcomes are not better in higher-spending areas. Most studies have focused on care in fee-for-service Medicare; whether spillover effects exist in settings without financial incentives for more care is unknown. : We studied care for cancer patients in fee-for-service Medicare and the Veterans Health Administration (VA) to understand whether processes and outcomes of care vary with area-level Medicare spending. : An observational study using logistic regression to assess care by area-level measures of Medicare spending. : Patients with lung, colorectal, or prostate cancers diagnosed during 2001-2004 in Surveillance, Epidemiology, and End Results (SEER) areas or the VA. The SEER cohort included fee-for-service Medicare patients aged older than 65 years. : Recommended and preference-sensitive cancer care and mortality. : In fee-for-service Medicare, higher-spending areas had higher rates of recommended care (curative surgery and adjuvant chemotherapy for early-stage non-small-cell lung cancer and chemotherapy for stage III colon cancer) and preference-sensitive care (chemotherapy for stage IV lung and colon cancer and primary treatment of local/regional prostate cancer) and had lower lung cancer mortality. In the VA, we observed minimal variation in care by area-level Medicare spending. : Our findings suggest that intensity of care for Medicare beneficiaries is not driving variations in VA care, despite some overlap in physician networks. Although the Dartmouth Atlas work has been of unprecedented importance in demonstrating variations in Medicare spending, new measures may be needed to better understand variations in other populations.

Site Environmental Report for Calendar Year 2001. DOE Operations at The Boeing Company, Rocketdyne Propulsion & Power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rutherford, Phil; Samuels, Sandy; Leee, Majelle

2002-09-01

This Annual Site Environmental Report (ASER) for 2001 describes the environmental conditions related to work performed for the Department of Energy (DOE) at Area IV of the Boeing Rocketdyne Santa Susana Field Laboratory (SSFL). In the past, these operations included development, fabrication, and disassembly of nuclear reactors, reactor fuel, and other radioactive materials under the former Atomics International (AI) Division. Other activities included the operation of large-scale liquid metal facilities for testing of liquid metal fast breeder components at the Energy Technology Engineering Center (ETEC), a government-owned, company-operated test facility within Area IV. All nuclear work was terminated in 1988,more » and subsequently, all radiological work has been directed toward decontamination and decommissioning (D&D) of the previously used nuclear facilities and associated site areas. Closure of the sodium test facilities began in 1996. Results of the radiological monitoring program for the calendar year of 2001 continue to indicate that there are no significant releases of radioactive material from Area IV of SSFL. All potential exposure pathways are sampled and/or monitored, including air, soil, surface water, groundwater, direct radiation, transfer of property (land, structures, waste), and recycling. All radioactive wastes are processed for disposal at DOE disposal sites and other sites approved by DOE and licensed for radioactive waste. Liquid radioactive wastes are not released into the environment and do not constitute an exposure pathway. No structural debris from buildings, released for unrestricted use, was transferred to municipal landfills or recycled in 2001.« less

Empirical studies assessing the quality of health information for consumers on the world wide web: a systematic review.

PubMed

Eysenbach, Gunther; Powell, John; Kuss, Oliver; Sa, Eun-Ryoung

The quality of consumer health information on the World Wide Web is an important issue for medicine, but to date no systematic and comprehensive synthesis of the methods and evidence has been performed. To establish a methodological framework on how quality on the Web is evaluated in practice, to determine the heterogeneity of the results and conclusions, and to compare the methodological rigor of these studies, to determine to what extent the conclusions depend on the methodology used, and to suggest future directions for research. We searched MEDLINE and PREMEDLINE (1966 through September 2001), Science Citation Index (1997 through September 2001), Social Sciences Citation Index (1997 through September 2001), Arts and Humanities Citation Index (1997 through September 2001), LISA (1969 through July 2001), CINAHL (1982 through July 2001), PsychINFO (1988 through September 2001), EMBASE (1988 through June 2001), and SIGLE (1980 through June 2001). We also conducted hand searches, general Internet searches, and a personal bibliographic database search. We included published and unpublished empirical studies in any language in which investigators searched the Web systematically for specific health information, evaluated the quality of Web sites or pages, and reported quantitative results. We screened 7830 citations and retrieved 170 potentially eligible full articles. A total of 79 distinct studies met the inclusion criteria, evaluating 5941 health Web sites and 1329 Web pages, and reporting 408 evaluation results for 86 different quality criteria. Two reviewers independently extracted study characteristics, medical domains, search strategies used, methods and criteria of quality assessment, results (percentage of sites or pages rated as inadequate pertaining to a quality criterion), and quality and rigor of study methods and reporting. Most frequently used quality criteria used include accuracy, completeness, readability, design, disclosures, and references provided. Fifty-five studies (70%) concluded that quality is a problem on the Web, 17 (22%) remained neutral, and 7 studies (9%) came to a positive conclusion. Positive studies scored significantly lower in search (P =.02) and evaluation (P =.04) methods. Due to differences in study methods and rigor, quality criteria, study population, and topic chosen, study results and conclusions on health-related Web sites vary widely. Operational definitions of quality criteria are needed.

Registrar Staging Assistant (SEER*RSA) - SEER

Cancer.gov

Use this site for cases diagnosed 2018 and forward to code Extent of Disease 2018, Summary Stage 2018, Site-Specific Data Items, and Grade. Use it for 2016 and 2017 cases to determine UICC TNM 7th edition stage, Collaborative Stage v.02.05.50, and Site-Specific predictive and prognostic factors.

The World Trade Center Attack: Similarities to the 1988 earthquake in Armenia: time to teach the public life-supporting first aid?

PubMed Central

Crippen, David

2001-01-01

On 7 December 1988, a severe earthquake hit in Armenia, a former republic of the Soviet Union (USSR); on 11 September 2001, a manmade attack of similar impact hit New York City. These events share similar implications for the role of the uninjured survivor. With basic training, the uninjured survivors could save lives without tools or resuscitation equipment. This article makes the case for teaching life-supporting first aid to the public in the hope that one day, should another such incident occur, they would be able to preserve injured victims until formal rescue occurs. PMID:11737915

Computer Courseware Evaluations. January 1988 to December 1988. Volume VIII.

ERIC Educational Resources Information Center

Riome, Carol-Anne, Comp.

The eighth in a series, this report reviews microcomputer software authorized by the Alberta (Canada) Department of Education from January 1988 through December 1988. This edition provides detailed evaluations of 40 authorized programs for teaching business education, computer literacy, databases, file management, French, information retrieval,…

Multidisciplinary clinic approach improves overall survival outcomes of patients with metastatic germ-cell tumors.

PubMed

Albany, C; Adra, N; Snavely, A C; Cary, C; Masterson, T A; Foster, R S; Kesler, K; Ulbright, T M; Cheng, L; Chovanec, M; Taza, F; Ku, K; Brames, M J; Hanna, N H; Einhorn, L H

2018-02-01

To report our experience utilizing a multidisciplinary clinic (MDC) at Indiana University (IU) since the publication of the International Germ Cell Cancer Collaborative Group (IGCCCG), and to compare our overall survival (OS) to that of the National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) Program. We conducted a retrospective analysis of all patients with metastatic germ-cell tumor (GCT) seen at IU from 1998 to 2014. A total of 1611 consecutive patients were identified, of whom 704 patients received an initial evaluation by our MDC (including medical oncology, pathology, urology and thoracic surgery) and started first-line chemotherapy at IU. These 704 patients were eligible for analysis. All patients in this cohort were treated with cisplatin-etoposide-based combination chemotherapy. We compared the progression-free survival (PFS) and OS of patients treated at IU with that of the published IGCCCG cohort. OS of the IU testis cancer primary cohort (n = 622) was further compared with the SEER data of 1283 patients labeled with 'distant' disease. The Kaplan-Meier method was used to estimate PFS and OS. With a median follow-up of 4.4 years, patients with good, intermediate, and poor risk disease by IGCCCG criteria treated at IU had 5-year PFS of 90%, 84%, and 54% and 5-year OS of 97%, 92%, and 73%, respectively. The 5-year PFS for all patients in the IU cohort was 79% [95% confidence interval (CI) 76% to 82%]. The 5-year OS for the IU cohort was 90% (95% CI 87% to 92%). IU testis cohort had 5-year OS 94% (95% CI 91% to 96%) versus 75% (95% CI 73% to 78%) for the SEER 'distant' cohort between 2000 and 2014, P-value <0.0001. The MDC approach to GCT at high-volume cancer center associated with improved OS outcomes in this contemporary dataset. OS is significantly higher in the IU cohort compared with the IGCCCG and SEER 'distant' cohort. © The Author 2017. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Outcomes after diagnosis of mycosis fungoides and Sézary syndrome before 30 years of age: a population-based study.

PubMed

Ai, Weiyun Z; Keegan, Theresa H; Press, David J; Yang, Juan; Pincus, Laura B; Kim, Youn H; Chang, Ellen T

2014-07-01

Mycosis fungoides and Sézary syndrome (MF/SS) are rare in children and young adults, and thus the incidence and outcomes in this patient population are not well studied. To assess the incidence and outcomes of MF/SS in patients diagnosed before 30 years of age. Retrospective study of 2 population-based cancer registries-the California Cancer Registry (n = 204) and 9 US cancer registries of the Surveillance, Epidemiology, and End Results program (SEER 9; n = 195)-for patients diagnosed with MF/SS before 30 years of age. Overall survival was calculated by the Kaplan-Meier method. The risk of a second cancer was assessed by calculating the standard incidence ratio (SIR) comparing observed cancer incidence in patients with MF/SS with the expected incidence in the age-, sex-, and race-standardized general population. The incidence of MF/SS is rare before 30 years of age, with an incidence rate of 0.05 per 100,000 persons per year before age 20 years and 0.12 per 100,000 persons per year between ages 20 and 29 years in the California Cancer Registry. At 10 years, patients with MF/SS had an overall survival of 94.3% (95% CI, 89.6%-97.2%) in the California Cancer Registry and 88.9% (95% CI, 82.4%-93.2%) in SEER 9. In SEER 9, there was a significant excess risk of all types of second cancers combined (SIR, 3.40; 95% CI, 1.55-6.45), particularly lymphoma (SIR, 12.86; 95% CI, 2.65-37.59) and melanoma (SIR, 9.31; 95% CI, 8.75-33.62). In the California Cancer Registry, the SIR for risk of all types of second cancers was similar to that in SEER 9 (SIR, 3.45; 95% CI, 0.94-8.83), although not statistically significant. Young patients with MF/SS have a favorable outcome, despite a strong suggestion of an increased risk of second primary cancers. Prolonged follow-up is warranted to definitively assess their risk of developing second cancers in a lifetime.

Breast-cancer-specific mortality in patients treated based on the 21-gene assay: a SEER population-based study

PubMed Central

Petkov, Valentina I; Miller, Dave P; Howlader, Nadia; Gliner, Nathan; Howe, Will; Schussler, Nicola; Cronin, Kathleen; Baehner, Frederick L; Cress, Rosemary; Deapen, Dennis; Glaser, Sally L; Hernandez, Brenda Y; Lynch, Charles F; Mueller, Lloyd; Schwartz, Ann G; Schwartz, Stephen M; Stroup, Antoinette; Sweeney, Carol; Tucker, Thomas C; Ward, Kevin C; Wiggins, Charles; Wu, Xiao-Cheng; Penberthy, Lynne; Shak, Steven

2016-01-01

The 21-gene Recurrence Score assay is validated to predict recurrence risk and chemotherapy benefit in hormone-receptor-positive (HR+) invasive breast cancer. To determine prospective breast-cancer-specific mortality (BCSM) outcomes by baseline Recurrence Score results and clinical covariates, the National Cancer Institute collaborated with Genomic Health and 14 population-based registries in the the Surveillance, Epidemiology, and End Results (SEER) Program to electronically supplement cancer surveillance data with Recurrence Score results. The prespecified primary analysis cohort was 40–84 years of age, and had node-negative, HR+, HER2-negative, nonmetastatic disease diagnosed between January 2004 and December 2011 in the entire SEER population, and Recurrence Score results (N=38,568). Unadjusted 5-year BCSM were 0.4% (n=21,023; 95% confidence interval (CI), 0.3–0.6%), 1.4% (n=14,494; 95% CI, 1.1–1.7%), and 4.4% (n=3,051; 95% CI, 3.4–5.6%) for Recurrence Score <18, 18–30, and ⩾31 groups, respectively (P<0.001). In multivariable analysis adjusted for age, tumor size, grade, and race, the Recurrence Score result predicted BCSM (P<0.001). Among patients with node-positive disease (micrometastases and up to three positive nodes; N=4,691), 5-year BCSM (unadjusted) was 1.0% (n=2,694; 95% CI, 0.5–2.0%), 2.3% (n=1,669; 95% CI, 1.3–4.1%), and 14.3% (n=328; 95% CI, 8.4–23.8%) for Recurrence Score <18, 18–30, ⩾31 groups, respectively (P<0.001). Five-year BCSM by Recurrence Score group are reported for important patient subgroups, including age, race, tumor size, grade, and socioeconomic status. This SEER study represents the largest report of prospective BCSM outcomes based on Recurrence Score results for patients with HR+, HER2-negative, node-negative, or node-positive breast cancer, including subgroups often under-represented in clinical trials. PMID:28721379

Ambient air emissions of polycyclic aromatic hydrocarbons and female breast cancer incidence in US.

PubMed

Stults, William Parker; Wei, Yudan

2018-05-05

To examine ambient air pollutants, specifically polycyclic aromatic hydrocarbons (PAHs), as a factor in the geographic variation of breast cancer incidence seen in the US, we conducted an ecological study involving counties throughout the US to examine breast cancer incidence in relation to PAH emissions in ambient air. Age-adjusted incidence rates of female breast cancer from the surveillance, epidemiology, and end results (SEER) program of the US National Cancer Institute were collected and analyzed using SEER*Stat 8.3.2. PAH emissions data were obtained from the Environmental Protection Agency. Linear regression analysis was performed using SPSS 23 software for Windows to analyze the association between PAH emissions and breast cancer incidence, adjusting for potential confounders. Age-adjusted incidence rates of female breast cancer were found being significantly higher in more industrialized metropolitan SEER regions over the years of 1973-2013 as compared to less industrialized regions. After adjusting for sex, race, education, socioeconomic status, obesity, and smoking prevalence, PAH emission density was found to be significantly associated with female breast cancer incidence, with the adjusted β of 0.424 (95% CI 0.278, 0.570; p < 0.0001) for emissions from all sources and of 0.552 (95% CI 0.278, 0.826; p < 0.0001) for emissions from traffic source. This study suggests that PAH exposure from ambient air could play a role in the increased breast cancer risk among women living in urban areas of the US. Further research could provide insight into breast cancer etiology and prevention.

49 CFR 171.7 - Reference material.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., 1988, into § 174.55; 174.63. (3) AAR Specifications for Design, Fabrication and Construction of Freight... Edition), into § 172.400a. (8) CGA Pamphlet C-8, Standard for Requalification of DOT-3HT Cylinder Design... Compressed Gas Cylinders at Time of Manufacture, 2001, Third Edition, into § 178.35. (10) CGA Pamphlet C-12...

Do British Columbia's Recent Education Policy Changes Enhance Professionalism among Teachers?

ERIC Educational Resources Information Center

Grimmett, Peter P.; D'Amico, Laura

2008-01-01

Beginning with the Sullivan Royal Commission on Education in 1988, British Columbia (BC) teachers experienced a policy context that led to a decade of intense professional learning around innovative instructional strategies and curriculum. From 2001 on, the policy context changed considerably. There has been a flurry of changes designed to bring…

EMERITUS: An Engineer-Manager’s Evaluation, Review Improvement Tool

DTIC Science & Technology

1990-05-01

Donald L., "Excerpts from - Management Time: who’s Got The Monkey?," Harvard Business Review (March - April, 1987), p. 25. Peters, Thomas J., and...Management Conference, from AT to JZ, (24-26 October 1988), p. 116-119. 59 The Samuel Neaman Institute--Technion Report, "Engineering Education 2001

Fatality Analysis Reporting System, General Estimates System: 2001 Data Summary.

ERIC Educational Resources Information Center

2003

The Fatality Analysis Reporting System (FARS), which became operational in 1975, contains data on a census of fatal traffic crashes within the 50 states, the District of Columbia, and Puerto Rico. The General Estimates System (GES), which began in 1988, provides data from a nationally representative probability sample selected from all…

76 FR 20870 - Protective Regulations for Killer Whales in the Northwest Region Under the Endangered Species Act...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-14

... spent foraging and significant increase in overall time spent traveling when vessels were present within... 1988; Forest 2001; Morton and Symonds 2002; Courbis 2004; Bejder et al. 2006); altering travel patterns... swimming faster, adopting less predictable travel paths, making shorter or longer dives, moving into open...

49 CFR 171.7 - Reference material.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Intermodal Equipment, 1988, into § 174.55; 174.63. (3) AAR Specifications for Design, Fabrication and... Edition), into § 172.400a. (8) CGA Pamphlet C-8, Standard for Requalification of DOT-3HT Cylinder Design... Compressed Gas Cylinders at Time of Manufacture, 2001, Third Edition, into § 178.35. (10) CGA Pamphlet C-12...

Curriculum Gatekeeping in Global Education: Global Educators' Perspectives

ERIC Educational Resources Information Center

Bailey, Robert W.

2013-01-01

Teaching social studies from a global perspective has been resisted by many since its inception (Kirkwood, 2009). Critics have labeled the theory anti-American and unpatriotic (Schlafly, 1986; Burack, 2001). Others are concerned with its shifting perspectives and apparent lack of core facts (Finn, 1988). Over time, some critics have changed their…

10 CFR 430.3 - Materials incorporated by reference.

Code of Federal Regulations, 2014 CFR

2014-01-01

....2. (18) ANSI Z21.88-2009 (CSA 2.33-2009), (“ANSI Z21.88”), Vented Gas Fireplace Heaters, Fifth... approved October 18, 1988, and reaffirmed June 20, 2009. ANSI approved October 20, 1998 and reaffirmed June...) ASHRAE 41.1-1986 (Reaffirmed 2001), Standard Method for Temperature Measurement, approved February 18...

Changes in the prevalence of vocal symptoms among teachers during a twelve-year period.

PubMed

Simberg, Susanna; Sala, Eeva; Vehmas, Kirsti; Laine, Anneli

2005-03-01

Vocal symptoms and voice disorders among teachers were studied in 1988 using a questionnaire designed to obtain information on six vocal symptoms that had appeared during the past 2 years. Twelve percent of the 478 respondents reported vocal symptoms occurring weekly or more often. The study was repeated using the same questionnaire in 2001. The results of this second study (n=241) indicate that vocal symptoms had increased considerably. Twenty-nine percent of the teachers reported symptoms occurring weekly or more often, and 20% reported two symptoms or more occurring at least once a week, which is significantly more than in 1988. Accordingly, voice disorders are probably a growing problem among teachers. Several factors may explain these increases. In 2001, the teachers complained more often about increases in the size of their classes. Factors that disturbed normal work routines, such as noisy or misbehaving pupils, had also increased significantly. A growing number of misbehaving pupils probably cause increased background noise and stress and, thus, increase the vocal symptoms in teachers.

Long-Term Ethylene Oxide Exposure Trends in US Hospitals: Relationship With OSHA Regulatory and Enforcement Actions

PubMed Central

LaMontagne, Anthony D.; Oakes, J. Michael; Lopez Turley, Ruth N.

2004-01-01

Objectives. We assessed long-term trends in ethylene oxide (EtO) worker exposures for the purposes of exposure surveillance and evaluation of the impacts of the Occupational Safety and Health Administration (OSHA) 1984 and 1988 EtO standards. Methods. We obtained exposure data from a large commercial vendor and processor of EtO passive dosimeters. Personal samples (87 582 workshift [8-hr] and 46 097 short-term [15-min] samples) from 2265 US hospitals were analyzed for time trends from 1984 through 2001 and compared with OSHA enforcement data. Results. Exposures declined steadily for the first several years after the OSHA standards were set. Workshift exposures continued to taper off and have remained low and constant through 2001. However, since 1996, the probability of exceeding the short-term excursion limit has increased. This trend coincides with a decline in enforcement of the EtO standard. Conclusions. Results indicate the need for renewed intervention efforts to preserve gains made following the passage and implementation of the 1984 and 1988 EtO standards. PMID:15333324

Software Technology for Adaptable, Reliable Systems (STARS)

DTIC Science & Technology

1994-03-25

Tmeline(3), SECOMO(3), SEER(3), GSFC Software Engineering Lab Model(l), SLIM(4), SEER-SEM(l), SPQR (2), PRICE-S(2), internally-developed models(3), APMSS(1...3 " Timeline - 3 " SASET (Software Architecture Sizing Estimating Tool) - 2 " MicroMan 11- 2 * LCM (Logistics Cost Model) - 2 * SPQR - 2 * PRICE-S - 2

Causes of death in long-term lung cancer survivors: a SEER database analysis.

PubMed

Abdel-Rahman, Omar

2017-07-01

Long-term (>5 years) lung cancer survivors represent a small but distinct subgroup of lung cancer patients and information about the causes of death of this subgroup is scarce. The Surveillance, Epidemiology and End Results (SEER) database (1988-2008) was utilized to determine the causes of death of long-term survivors of lung cancer. Survival analysis was conducted using Kaplan-Meier analysis and multivariate analysis was conducted using a Cox proportional hazard model. Clinicopathological characteristics and survival outcomes were assessed for the whole cohort. A total of 78,701 lung cancer patients with >5 years survival were identified. This cohort included 54,488 patients surviving 5-10 years and 24,213 patients surviving >10 years. Among patients surviving 5-10 years, 21.8% were dead because of primary lung cancer, 10.2% were dead because of other cancers, 6.8% were dead because of cardiac disease and 5.3% were dead because of non-malignant pulmonary disease. Among patients surviving >10 years, 12% were dead because of primary lung cancer, 6% were dead because of other cancers, 6.9% were dead because of cardiac disease and 5.6% were dead because of non-malignant pulmonary disease. On multivariate analysis, factors associated with longer cardiac-disease-specific survival in multivariate analysis include younger age at diagnosis (p < .0001), white race (vs. African American race) (p = .005), female gender (p < .0001), right-sided disease (p = .003), adenocarcinoma (vs. large cell or small cell carcinoma), histology and receiving local treatment by surgery rather than radiotherapy (p < .0001). The probability of death from primary lung cancer is still significant among other causes of death even 20 years after diagnosis of lung cancer. Moreover, cardiac as well as non-malignant pulmonary causes contribute a considerable proportion of deaths in long-term lung cancer survivors.

Annual Program: Library Services and Construction Act, 1987-1988.

ERIC Educational Resources Information Center

South Carolina State Library, Columbia.

This report presents the 1978-1988 annual Library Services and Construction Act (LSCA) program for the South Carolina State Library. This program includes fiscal information and project descriptions for the following LCSA projects under Title I-Library Services: (1) Projects IA-General Administration; (2) IB-Library Interpretation; (3) IIA-General…

Opisthorchiasis control in Thailand.

PubMed

Jongsuksuntigul, P; Imsomboon, T

2003-11-01

History of opisthorchiasis control started in 1950 as a small scale helminthiasis control program in some high risk areas. Following a number of studies and trial projects of the Faculty of Tropical Medicine, Mahidol University, the national liver fluke control program has been developed and operated under several National Public Health Development Plans. Presently, the program is being operated in some provinces of the Central, and all provinces of the Northeast and North of Thailand. The main strategies for liver fluke control comprise of three interrelated approaches, namely stool examinations and treatment of positive cases with praziquantel for eliminating human host reservoir; health education for a promotion of cooked fish consumption to prevent infection, and the improvement of hygienic defecation for the interruption of disease transmission. Between 1984 and 1987, the positive rate of liver fluke infection was 63.6%. In 1988, the positive rate went down to 35.6%. Following the region wide control program started in 1989, the annual positive rates had subsequently decreased to 9.4% in the year 2001. The prevalence rate was remarkably high in the North and moderately high in the Northeast, while the prevalence in the Central region was considerably low and there was no evidence of disease transmission in the South.

A Program of Basic Research for High Power Switching and Other High Power Devices

DTIC Science & Technology

1989-05-23

Physics Topical Group/American Physical Society, Baltimore, Maryland, April 18-21, 1988, Bull. Am. Phys. Soc. 33, 1082 (1988). "New High Power Thyratrons...American Physical Society, Baltimore, Maryland, April 18-21, 1988, Bull. Am. Phys. Soc. 33, 1082 (1988). "A plasma lens candidate with highly stable...April 18-21, 1988, Bull. Am. Phys. Soc. 33. 1082 (1988). "New High Power Thyratrons for High Energy Physics Applications," W. Hartmann, G. Kirkman, M.A

Central nervous system tumours among adolescents and young adults (15-39 years) in Southern and Eastern Europe: Registration improvements reveal higher incidence rates compared to the US.

PubMed

Georgakis, Marios K; Panagopoulou, Paraskevi; Papathoma, Paraskevi; Tragiannidis, Athanasios; Ryzhov, Anton; Zivkovic-Perisic, Snezana; Eser, Sultan; Taraszkiewicz, Łukasz; Sekerija, Mario; Žagar, Tina; Antunes, Luis; Zborovskaya, Anna; Bastos, Joana; Florea, Margareta; Coza, Daniela; Demetriou, Anna; Agius, Domenic; Strahinja, Rajko M; Sfakianos, Georgios; Nikas, Ioannis; Kosmidis, Sofia; Razis, Evangelia; Pourtsidis, Apostolos; Kantzanou, Maria; Dessypris, Nick; Petridou, Eleni Th

2017-11-01

To present incidence of central nervous system (CNS) tumours among adolescents and young adults (AYAs; 15-39 years) derived from registries of Southern and Eastern Europe (SEE) in comparison to the Surveillance, Epidemiology and End Results (SEER), US and explore changes due to etiological parameters or registration improvement via evaluating time trends. Diagnoses of 11,438 incident malignant CNS tumours in AYAs (1990-2014) were retrieved from 14 collaborating SEE cancer registries and 13,573 from the publicly available SEER database (1990-2012). Age-adjusted incidence rates (AIRs) were calculated; Poisson and joinpoint regression analyses were performed for temporal trends. The overall AIR of malignant CNS tumours among AYAs was higher in SEE (28.1/million) compared to SEER (24.7/million). Astrocytomas comprised almost half of the cases in both regions, albeit the higher proportion of unspecified cases in SEE registries (30% versus 2.5% in SEER). Similar were the age and gender distributions across SEE and SEER with a male-to-female ratio of 1.3 and an overall increase of incidence by age. Increasing temporal trends in incidence were documented in four SEE registries (Greater Poland, Portugal North, Turkey-Izmir and Ukraine) versus an annual decrease in Croatia (-2.5%) and a rather stable rate in SEER (-0.3%). This first report on descriptive epidemiology of AYAs malignant CNS tumours in the SEE area shows higher incidence rates as compared to the United States of America and variable temporal trends that may be linked to registration improvements. Hence, it emphasises the need for optimisation of cancer registration processes, as to enable the in-depth evaluation of the observed patterns by disease subtype. Copyright © 2017 Elsevier Ltd. All rights reserved.

Malignancies in children and young adults on etanercept: summary of cases from clinical trials and post marketing reports.

PubMed

Hooper, Michele; Wenkert, Deborah; Bitman, Bojena; Dias, Virgil C; Bartley, Yessenia

2013-10-02

Malignancy risk may be increased in chronic inflammatory conditions that are mediated by tumor necrosis factor (TNF), such as juvenile idiopathic arthritis (JIA), but the role of TNF in human cancer biology is unclear. In response to a 2011 United States Food & Drug Administration requirement of TNF blocker manufacturers, we evaluated reporting rates of all malignancies in patients =30 years old who received the TNF blocker etanercept. All malignancies in etanercept-exposed patients aged =30 years from the Amgen clinical trial database (CTD) and postmarketing global safety database (PMD) were reviewed. PMD reporting rates were generated using exposure information based on commercial sources. Age-specific incidence rates of malignancy for the general US population were generated from the Surveillance Epidemiology and End Results (SEER) database v7.0.9. There were 2 malignancies in the CTD: 1 each in etanercept and placebo/comparator arms (both in patients 18-30 years old). Postmarketing etanercept exposure was 231,404 patient-years (62,379 patient-years in patients 0-17 years; 168,485 patient-years in patients 18-30 years). Reporting rates of malignancy per 100,000 patient-years in the PMD and incidence rates in SEER were 32.0 and 15.9, respectively, for patients 0-17 years and 46.9 and 42.1 for patients 18-30 years old. Reporting rates were higher than SEER incidence rates for Hodgkin lymphoma in the 0-17 years age group. PMD reporting rates per 100,000 patient-years and SEER incidence rates per 100,000 person-years for Hodgkin lymphoma were 9.54 and 0.9, respectively, for patients 0-17 years and 1.8 and 4.2 for patients 18-30 years old. There were =5 cases of leukemia, lymphoma, melanoma, thyroid, and cervical cancers. Leukemia, non-Hodgkin lymphoma, melanoma, thyroid cancer, and cervical cancer rates were similar in the PMD and SEER. Overall PMD malignancy reporting rates in etanercept-treated patients 0-17 years appeared higher than incidence rates in SEER, attributable to rates of Hodgkin lymphoma. Comparison to patients with similar burden of disease cannot be made; JIA, particularly very active disease, may be a risk factor for lymphoma. No increased malignancy reporting rate in the PMD relative to SEER was observed in the young-adult age group.

Molecular epidemiology of type 1 and 2 dengue viruses in Brazil from 1988 to 2001.

PubMed

Pires Neto, R J; Lima, D M; de Paula, S O; Lima, C M; Rocco, I M; Fonseca, B A L

2005-06-01

Dengue is a mosquito-borne viral infection that in recent decades has become a major international public health concern. Epidemic dengue fever reemerged in Brazil in 1981. Since 1990 more than one dengue virus serotype has been circulating in this tropical country and increasing rates of dengue hemorrhagic fever and dengue shock syndrome have been detected every year. Some evidence supports the association between the introduction of a new serotype and/or genotype in a region and the appearance of dengue hemorrhagic fever. In order to study the evolutionary relationships and possible detection of the introduction of new dengue virus genotypes in Brazil in the last years, we analyzed partial nucleotide sequences of 52 Brazilian samples of both dengue type 1 and dengue type 2 isolated from 1988 to 2001 from highly endemic regions. A 240-nucleotide-long sequence from the envelope/nonstructural protein 1 gene junction was used for phylogenetic analysis. After comparing the nucleotide sequences originally obtained in this study to those previously studied by others, and analyzing the phylogenetic trees, we conclude that, after the initial introduction of the currently circulating dengue-1 and dengue-2 genotypes in Brazil, there has been no evidence of introduction of new genotypes since 1988. The increasing number of dengue hemorrhagic fever cases seen in Brazil in the last years is probably associated with secondary infections or with the introduction of new serotypes but not with the introduction of new genotypes.

Columbia River Basin Fish and Wildlife Program Work Plan for Fiscal Year 1989.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration. Division of Fish and Wildlife.

1988-11-01

The FY 1989 Columbia River Basin Fish and Wildlife Program Work Plan (Work Plan) presents Bonneville Power Administration's plans for implementing the Columbia River Basin Fish and Wildlife Program (Program) in FY 1989. The Work Plan focuses on individual Action Items found in the 1987 Program for which Bonneville Power Administration (BPA) has determined that it has authority and responsibility to implement. Each of the entries in the Work Plan includes objectives, background, and progress to date in achieving those objectives, and a summary of plans for implementation in FY 1989. Most Action Items are implemented through one or moremore » BPA-funded projects. Each Action Item entry is followed by a list of completed, ongoing, and planned projects, along with objectives, results, schedules, and milestones for each project. The FY 1989 Work Plan emphasizes continuation of 113 projects, most of which involve protection, mitigation, or enhancement of anadromous fishery resources. BPA also plans to start 20 new projects in FY 1989. The number of ongoing FY 1988 projects to be continued in FY 1989 and the number of new projects planned to start in FY 1989 are based on current (September 7, 1988) procurement expectations. Several projects presently in BPA's procurement process are expected to be contracted by September 30, 1988, the last day of FY 1988. Although these projects have not yet started, they have been listed in the Work Plan as ongoing FY 1988 projects, based on projected start dates in late September 1988. Throughout the Work Plan, those projects with projected start dates in September 1988 have been noted.« less

Technical Report from Grant Recipient - City of Redlands

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giorgianni, Kathleen Margaret

2016-05-26

The goals and objectives of the HVAC upgrades are to replace equipment as old as twenty-three (23) years in five different facilities. The project will upgrade some facilities from SEER ratings of 9 to SEER ratings of 14 at a savings of 556 kilowatt hours per ton (savings depends on specific size of the system).

Urbanization in Zambia. An International Urbanization Survey Report to the Ford Foundation.

ERIC Educational Resources Information Center

Simmance, Alan J. F.

This report reviews the "Seers Report," which contained policy guidelines for modern development planning in Zambia, and compares its findings to recent findings during the period 1963-1970. The Seers Report found that Zambia was the most urbanized country in Africa south of the Sahara (excluding South Africa). This report finds that…

Reports of planetary geology and geophysics program, 1988

NASA Technical Reports Server (NTRS)

Holt, Henry E. (Editor)

1989-01-01

This is a compilation of abstracts of reports from Principal Investigators of NASA's Planetary Geology and Geophysics Program, Office of Space Science and Applications. The purpose is to document in summary form research work conducted in this program during 1988. Each report reflects significant accomplishments within the area of the author's funded grant or contract.

Summer Bilingual Program, 1988. OREA Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Rosenberg, Jan

The 1988 Summer Bilingual Program served 1,171 ninth- through twelfth-graders with limited English proficiency (LEP) at 10 New York City sites. Designed especially for the substantial number of LEP students who were overage for their grade, the program offered 14 English as a Second Language (ESL) and 17 bilingual content area classes in science,…

Follow-Up Survey of the 1988-1989 Radiography Graduates of Middlesex Community College.

ERIC Educational Resources Information Center

Spence, Weymouth

A graduate follow-up survey evaluated student outcomes for the radiography program at Middlesex Community College/Middlesex Memorial Hospital (Connecticut). The program prepares students for entry-level employment as radiographers. The questionnaire, based on input from program officials and respondents, was mailed to 14 1988 and 1989 graduates.…

Annual Program. Library Services and Construction Act, 1988-1989.

ERIC Educational Resources Information Center

South Carolina State Library, Columbia.

This report presents the 1988-1989 annual Library Services and Construction Act (LSCA) program for the South Carolina State Library. This program includes fiscal information and project descriptions for the following LSCA projects under Title I Library Services: (1) I-A, General Administration; (2) I-B, Library Interpretation; (3) II-A, General…

Coding completeness and quality of relative survival-related variables in the National Program of Cancer Registries Cancer Surveillance System, 1995-2008.

PubMed

Wilson, Reda J; O'Neil, M E; Ntekop, E; Zhang, Kevin; Ren, Y

2014-01-01

Calculating accurate estimates of cancer survival is important for various analyses of cancer patient care and prognosis. Current US survival rates are estimated based on data from the National Cancer Institute's (NCI's) Surveillance, Epidemiology, and End RESULTS (SEER) program, covering approximately 28 percent of the US population. The National Program of Cancer Registries (NPCR) covers about 96 percent of the US population. Using a population-based database with greater US population coverage to calculate survival rates at the national, state, and regional levels can further enhance the effective monitoring of cancer patient care and prognosis in the United States. The first step is to establish the coding completeness and coding quality of the NPCR data needed for calculating survival rates and conducting related validation analyses. Using data from the NPCR-Cancer Surveillance System (CSS) from 1995 through 2008, we assessed coding completeness and quality on 26 data elements that are needed to calculate cancer relative survival estimates and conduct related analyses. Data elements evaluated consisted of demographic, follow-up, prognostic, and cancer identification variables. Analyses were performed showing trends of these variables by diagnostic year, state of residence at diagnosis, and cancer site. Mean overall percent coding completeness by each NPCR central cancer registry averaged across all data elements and diagnosis years ranged from 92.3 percent to 100 percent. RESULTS showing the mean percent coding completeness for the relative survival-related variables in NPCR data are presented. All data elements but 1 have a mean coding completeness greater than 90 percent as was the mean completeness by data item group type. Statistically significant differences in coding completeness were found in the ICD revision number, cause of death, vital status, and date of last contact variables when comparing diagnosis years. The majority of data items had a coding quality greater than 90 percent, with exceptions found in cause of death, follow-up source, and the SEER Summary Stage 1977, and SEER Summary Stage 2000. Percent coding completeness and quality are very high for variables in the NPCR-CSS that are covariates to calculating relative survival. NPCR provides the opportunity to calculate relative survival that may be more generalizable to the US population.

Reconnecting to Mission: Connecticut College's Outreach to New London during the Claire Gaudiani Era

ERIC Educational Resources Information Center

Marthers, Paul

2009-01-01

During her presidency (1988-2001), Claire Gaudiani reconnected Connecticut College with New London, the college's home city, whose citizens through grassroots fund raising and donations of land established the college in 1911. Through an emphasis on service-learning, community outreach, and an education not for oneself as well as economic…

The Relationship between Student Leaders' Constructive Development, Their Leadership Identity, and Their Understanding of Leadership

ERIC Educational Resources Information Center

Sessa, Valerie I.; Ploskonka, Jillian; Alvarez, Elphys L.; Dourdis, Steven; Dixon, Christopher; Bragger, Jennifer D.

2016-01-01

The purpose of our research was to use Day, Harrison, and Halpin's, (2009) theory of leadership development as a premise to investigate how students' constructive development is related to their leader identity development and understanding of leadership. Baxter Magolda's Model of Epistemological Reflection (MER, 1988, 2001) was used to understand…

Risk of myeloid neoplasms after radiotherapy among older women with localized breast cancer: A population-based study

PubMed Central

Long, Jessica B.; Wang, Rong; Hu, Xin; Yu, James B.; Huntington, Scott F.; Abel, Gregory A.; Mougalian, Sarah S.; Podoltsev, Nikolai A.; Gore, Steven D.; Gross, Cary P.; Ma, Xiaomei; Davidoff, Amy J.

2017-01-01

Background There are inconsistent and limited data regarding the risk of myeloid neoplasms (MN) among breast cancer survivors who received radiotherapy (RT) in the absence of chemotherapy. Concern about subsequent MN might influence the decision to use adjuvant RT for women with localized disease. As patients with therapy-related MN have generally poor outcomes, the presumption of subsequent MN being therapy-related could affect treatment recommendations. Methods We used the Surveillance, Epidemiology, and End Results (SEER)–Medicare linked database to study older women with in-situ or stage 1–3 breast cancer diagnosed 2001–2009 who received surgery. Chemotherapy and RT were ascertained using Medicare claims, and new MN diagnoses were captured using both SEER registry and Medicare claims. We excluded women who received chemotherapy for initial treatment, and censored at receipt of subsequent chemotherapy. Competing-risk survival analysis was used to assess the association between RT and risk of subsequent MN adjusting for relevant characteristics. Results Median follow-up for 60,426 eligible patients was 68 months (interquartile range, 46 to 92 months), with 47.6% receiving RT. In total, 316 patients (0.52%) were diagnosed with MN; the cumulative incidence per 10,000 person-years was 10.6 vs 9.0 among RT-treated vs non-RT-treated women, respectively (p = .004); the increased risk of subsequent MN persisted in the adjusted analysis (hazard ratio = 1.36, 95% confidence interval: 1.03–1.80). The results were consistent in multiple sensitivity analyses. Conclusions Our data suggest that RT is associated with a significant risk of subsequent MN among older breast cancer survivors, though the absolute risk increase is very small. These findings suggest the benefits of RT outweigh the risks of development of subsequent MN. PMID:28902882

A System Dynamics Model of Serum Prostate-Specific Antigen Screening for Prostate Cancer.

PubMed

Palma, Anton; Lounsbury, David W; Schlecht, Nicolas F; Agalliu, Ilir

2016-02-01

Since 2012, US guidelines have recommended against prostate-specific antigen (PSA) screening for prostate cancer. However, evidence of screening benefit from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening trial and the European Randomized Study of Screening for Prostate Cancer has been inconsistent, due partly to differences in noncompliance and contamination. Using system dynamics modeling, we replicated the PLCO trial and extrapolated follow-up to 20 years. We then simulated 3 scenarios correcting for contamination in the PLCO control arm using Surveillance, Epidemiology, and End Results (SEER) incidence and survival data collected prior to the PSA screening era (scenario 1), SEER data collected during the PLCO trial period (1993-2001) (scenario 2), and data from the European trial's control arm (1991-2005) (scenario 3). In all scenarios, noncompliance was corrected using incidence and survival rates for men with screen-detected cancer in the PLCO screening arm. Scenarios 1 and 3 showed a benefit of PSA screening, with relative risks of 0.62 (95% confidence interval: 0.53, 0.72) and 0.70 (95% confidence interval: 0.59, 0.83) for cancer-specific mortality after 20 years, respectively. In scenario 2, however, there was no benefit of screening. This simulation showed that after correcting for noncompliance and contamination, there is potential benefit of PSA screening in reducing prostate cancer mortality. It also demonstrates the utility of system dynamics modeling for synthesizing epidemiologic evidence to inform public policy. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Quality assessment of lymph node sampling in rhabdomyosarcoma: A surveillance, epidemiology, and end results (SEER) program study.

PubMed

Lobeck, Inna; Dupree, Phylicia; Karns, Rebekah; Rodeberg, David; von Allmen, Daniel; Dasgupta, Roshni

2017-04-01

Lymph node sampling is integral in the management of extremity and paratesticular rhabdomyosarcoma (RMS). The aim of this study was to determine overall surgical compliance with treatment protocols and impact of nodal sampling outcomes in these tumors. A query of the surveillance, epidemiology, and end results program (SEER) database was performed from 2003 to 2008 for patients <19years of age with RMS. Data obtained included demographics, five-year survival and rate of nodal sampling. Analysis was performed utilizing chi-squared, Kaplan-Meier and hazard ratio modeling. Of 537 patients with extremity RMS, nodal sampling was performed in 25.7% (n=138). This lack of nodal sampling had a negative outcome on survival (p=0.004). Sixty five patients with paratesticular RMS aged greater than 10 were identified and also displayed low rates of lymph node sampling (47.7%, n=31). For paratesticular patients, a similar increase in survival was seen in patients who underwent nodal evaluation (p=0.024). Lymph node sampling is the standard of care in RMS. However, surgical compliance with treatment protocols is poor. Nodal evaluation correlated significantly with overall survival. These findings suggest a need for improved education among surgeons and oncologists regarding the need lymph node assessment in pediatric oncology patients. Evidence rating/classification: Prognosis study, Level III. Copyright © 2017 Elsevier Inc. All rights reserved.

Variation in prostate cancer treatment associated with population density of the county of residence.

PubMed

Cary, C; Odisho, A Y; Cooperberg, M R

2016-06-01

We sought to assess variation in the primary treatment of prostate cancer by examining the effect of population density of the county of residence on treatment for clinically localized prostate cancer and quantify variation in primary treatment attributable to the county and state level. A total 138 226 men with clinically localized prostate cancer in the Surveillance, Epidemiology and End Result (SEER) database in 2005 through 2008 were analyzed. The main association of interest was between prostate cancer treatment and population density using multilevel hierarchical logit models while accounting for the random effects of counties nested within SEER regions. To quantify the effect of county and SEER region on individual treatment, the percent of total variance in treatment attributable to county of residence and SEER site was estimated with residual intraclass correlation coefficients. Men with localized prostate cancer in metropolitan counties had 23% higher odds of being treated with surgery or radiation compared with men in rural counties, controlling for number of urologists per county as well as clinical and sociodemographic characteristics. Three percent (95% confidence interval (CI): 1.2-6.2%) of the total variation in treatment was attributable to SEER site, while 6% (95% CI: 4.3-9.0%) of variation was attributable to county of residence, adjusting for clinical and sociodemographic characteristics. Variation in treatment for localized prostate cancer exists for men living in different population-dense counties of the country. These findings highlight the importance of comparative effectiveness research to improve understanding of this variation and lead to a reduction in unwarranted variation.

NASA earth science and applications division: The program and plans for FY 1988-1989-1990

NASA Technical Reports Server (NTRS)

1988-01-01

Described here are the Division's research goals, priorities and emphases for the next several years and an outline of longer term plans. Included are highlights of recent accomplishments, current activities in FY 1988, research emphases in FY 1989, and longer term future plans. Data and information systems, the Geodynamics Program, the Land Processes Program, the Oceanic Processes Program, the Atmospheric Dynamics and Radiation Program, the Atmospheric Chemistry Program, and space flight programs are among the topic covered.

Annual progress report : for the period of January 2001 through December 2001 : Florida Transit Training Program (2001) : Florida Technical Assistance Program (2001)

DOT National Transportation Integrated Search

2001-01-01

The following progress report is intended to highlight the significant activities of the Florida Transit Training Program and Florida Technical Assistant Program for the 2001 year. Activities of the Florida Statewide Transit Training Program are pres...

State Profiles of the State-Administered Adult Education Program for Program Year 1988.

ERIC Educational Resources Information Center

Office of Vocational and Adult Education (ED), Washington, DC. Clearinghouse on Adult Education and Literacy.

These state profiles for Program Year 1988 contain information based on 1980 Census data and information taken from the Annual Financial and Statistical Reports submitted to the Department of Education by the states, Puerto Rico, and the Virgin Islands. State profiles are arranged alphabetically by state. For each state, these demographic…

School Community Education Program in New York City 1988-89. Volume II. OREA Evaluation Section Report.

ERIC Educational Resources Information Center

Guerrero, Frank; Abbott, Lori

This second volume of a four-volume evaluation of the 1988-89 New York City School Community Education Program (also known as the Umbrella Program) comprises reports evaluating nine innovative elementary school projects on social, ethnical, and environmental studies, four of which included staff development workshops. Evaluation sources included…

Fort Berthold Library Literacy Program. Final Performance Report, October 1, 1988-September 30, 1989.

ERIC Educational Resources Information Center

Fort Berthold Reservation Public Library, New Town, ND.

The report describes activities of the Fort Berthold Reservation Public Library (North Dakota) Literacy Program to meet six objectives for the 1988-89 project year. The program was designed specifically to promote literacy among three Native American tribes, the Mandan, Hidatsa, and Arikara. Objectives included acquisition of a library literacy…

78 FR 29786 - Computer Matching and Privacy Protection Act of 1988; Report of Matching Program: RRB and State...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-21

... RAILROAD RETIREMENT BOARD Computer Matching and Privacy Protection Act of 1988; Report of Matching...: Notice of a renewal of an existing computer matching program due to expire on May 24, 2013. SUMMARY: As... of its intent to renew an ongoing computer matching program. In this match, we provide certain...

Early estimates of SEER cancer incidence, 2014.

PubMed

Lewis, Denise Riedel; Chen, Huann-Sheng; Cockburn, Myles G; Wu, Xiao-Cheng; Stroup, Antoinette M; Midthune, Douglas N; Zou, Zhaohui; Krapcho, Martin F; Miller, Daniel G; Feuer, Eric J

2017-07-01

Cancer incidence rates and trends for cases diagnosed through 2014 using data reported to the Surveillance, Epidemiology, and End Results (SEER) program in February 2016 and a validation of rates and trends for cases diagnosed through 2013 and submitted in February 2015 using the November 2015 submission are reported. New cancer sites include the pancreas, kidney and renal pelvis, corpus and uterus, and childhood cancer sites for ages birth to 19 years inclusive. A new reporting delay model is presented for these estimates for more consistent results with the model used for the usual November SEER submissions, adjusting for the large case undercount in the February submission. Joinpoint regression methodology was used to assess trends. Delay-adjusted rates and trends were checked for validity between the February 2016 and November 2016 submissions. Validation revealed that the delay model provides similar estimates of eventual counts using either February or November submission data. Trends declined through 2014 for prostate and colon and rectum cancer for males and females, male and female lung cancer, and cervical cancer. Thyroid cancer and liver and intrahepatic bile duct cancer increased. Pancreas (male and female) and corpus and uterus cancer demonstrated a modest increase. Slight increases occurred for male kidney and renal pelvis, and for all childhood cancer sites for ages birth to 19 years. Evaluating early cancer data submissions, adjusted for reporting delay, produces timely and valid incidence rates and trends. The results of the current study support using delay-adjusted February submission data for valid incidence rate and trend estimates over several data cycles. Cancer 2017;123:2524-34. © 2017 American Cancer Society. © 2017 American Cancer Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Clinical correlates and prognostic value of different metastatic sites in patients with malignant melanoma of the skin: a SEER database analysis.

PubMed

Abdel-Rahman, Omar

2018-03-01

Population-based data on the clinical correlates and prognostic value of the pattern of metastases among patients with cutaneous melanoma are needed. Surveillance, Epidemiology and End Results (SEER) database (2010-2013) has been explored through SEER*Stat program. For each of six distant metastatic sites (bone, brain, liver, lung, distant lymph nodes, and skin/subcutaneous), relevant correlation with baseline characteristics were reported. Survival analysis has been conducted through Kaplan-Meier analysis, and multivariate analysis has been conducted through a Cox proportional hazard model. A total of 2691 patients with metastatic cutaneous melanoma were identified in the period from 2010 to 2013. Patients with isolated skin/subcutaneous metastases have the best overall and melanoma-specific survival (MSS) followed by patients with isolated distant lymph node metastases followed by patients with isolated lung metastases. Patients with isolated liver, bone, or brain metastases have the worst overall and MSS (p < .0001 for both end points). Multivariate analysis revealed that age more than 70 at diagnosis (p = .012); multiple sites of metastases (p <.0001), no surgery to the primary tumor (p <.0001), and no surgery to the metastatic disease (p < .0001) were associated with worse overall survival (OS). For MSS, nodal positivity (p = .038), multiple sites of metastases (p < .0001), no surgery to the primary tumor (p < .0001), and no surgery to the metastatic disease (p < .0001) were associated with worse survival. The prognosis of metastatic cutaneous melanoma patients differs considerably according to the site of distant metastases. Further prospective studies are required to evaluate the role of local treatment in the management of metastatic disease.

Conditional Survival in Pediatric Malignancies: Analysis of data from the Childhood Cancer Survivor Study and the Surveillance, Epidemiology and End Results Program

PubMed Central

Mertens, Ann C; Yong, Jian; Dietz, Andrew; Kreiter, Erin; Yasui, Yutaka; Bleyer, Archie; Armstrong, Gregory T; Robison, Leslie L; Wasilewski-Masker, Karen

2015-01-01

Background Long-term survivors of pediatric cancer are at risk for life-threatening late effects of their cancer. Previous studies have shown excesses in long-term mortality within high-risk groups defined by demographic and treatment characteristics. Methods To investigate conditional survival in a pediatric cancer population, we performed an analysis of conditional survival in the original Childhood Cancer Survivor Study (CCSS) cohort and the Surveillance, Epidemiology and End Results (SEER) database registry. The overall probability of death for patients in 5 years and 10 years after they survived 5, 10, 15, and 20 years since cancer diagnosis, and cause-specific death in 10 years for 5-year survivors were estimated using the cumulative incidence method. Results Among CCSS and SEER patients who were alive 5 years post cancer diagnosis, within each diagnosis group at least 92% are alive in the subsequent 5 years, except leukemia patients of whom only 88% of 5-year survivors remain alive in the subsequent 5 years. The probability of all-cause mortality in the next 10 years on patients who survived at least 5 years after diagnosis, was 8.8% in CCSS and 10.6% in SEER, approximately three quarter of which were due to neoplasms as causes of death. Conclusion The risk of death of pediatric cancer survivors in 10 years can vary between diagnosis groups by at most 12% even up to 20 years post diagnosis. This information is clinically important in counseling patients on their conditional survival, particularly when survivors are seen in long-term follow-up. PMID:25557134

Short-Term Outcomes of Screening Mammography Using Computer-Aided Detection

PubMed Central

Fenton, Joshua J.; Xing, Guibo; Elmore, Joann G.; Bang, Heejung; Chen, Steven L.; Lindfors, Karen K.; Baldwin, Laura-Mae

2013-01-01

Background Computer-aided detection (CAD) has rapidly diffused into screening mammography practice despite limited and conflicting data on its clinical effect. Objective To determine associations between CAD use during screening mammography and the incidence of ductal carcinoma in situ (DCIS) and invasive breast cancer, invasive cancer stage, and diagnostic testing. Design Retrospective cohort study. Setting Medicare program. Participants Women aged 67 to 89 years having screening mammography between 2001 and 2006 in U.S. SEER (Surveillance, Epidemiology and End Results) regions (409 459 mammograms from 163 099 women). Measurements Incident DCIS and invasive breast cancer within 1 year after mammography, invasive cancer stage, and diagnostic testing within 90 days after screening among women without breast cancer. Results From 2001 to 2006, CAD prevalence increased from 3.6% to 60.5%. Use of CAD was associated with greater DCIS incidence (adjusted odds ratio [OR], 1.17 [95% CI, 1.11 to 1.23]) but no difference in invasive breast cancer incidence (adjusted OR, 1.00 [CI, 0.97 to 1.03]). Among women with invasive cancer, CAD was associated with greater likelihood of stage I to II versus III to IV cancer (adjusted OR, 1.27 [CI, 1.14 to 1.41]). In women without breast cancer, CAD was associated with increased odds of diagnostic mammography (adjusted OR, 1.28 [CI, 1.27 to 1.29]), breast ultrasonography (adjusted OR, 1.07 [CI, 1.06 to 1.09]), and breast biopsy (adjusted OR, 1.10 [CI, 1.08 to 1.12]). Limitation Short follow-up for cancer stage, potential unmeasured confounding, and uncertain generalizability to younger women. Conclusion Use of CAD during screening mammography among Medicare enrollees is associated with increased DCIS incidence, the diagnosis of invasive breast cancer at earlier stages, and increased diagnostic testing among women without breast cancer. Primary Funding Source Center for Healthcare Policy and Research, University of California, Davis. PMID:23588746

Fall Chinook Salmon Spawning Ground Surveys in the Snake River Basin Upriver of Lower Granite Dam, Annual Report 2002.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garcia, Aaron P.; Bradbury, S.M.; Arnsberg, Billy D.

2003-09-01

Redd counts were used to document the spawning distribution of fall chinook salmon (Oncorhynchus tshawytscha) in the Snake River basin upriver of Lower Granite Dam. The first reported redd counts were from aerial searches conducted intermittently between 1959 and 1978 (Irving and Bjornn 1981, Witty 1988; Groves and Chandler 1996)(Appendix 1). In 1986, the Washington Department of Fish and Wildlife began an annual monitoring program that, in addition to the Snake River, included aerial searches of the Grande Ronde River the first year (Seidel and Bugert 1987), and the Imnaha River in subsequent years (Seidel et al. 1988; Bugert etmore » al. 1989-1991; Mendel et al. 1992). The U. S. Fish and Wildlife Service and Idaho Power Company began contributing to this effort in 1991 by increasing the number of aerial searches conducted each year and adding underwater searches in areas of the Snake River that were too deep to be searched from the air (Connor et al. 1993; Garcia et al. 1994a, 1994b, 1996-2001; Groves 1993; Groves and Chandler 1996). The Nez Perce Tribe added aerial searches in the Clearwater River basin beginning in 1988 (Arnsberg et. al 1992) and the Salmon River beginning in 1992. Currently searches are conducted cooperatively by the Nez Perce Tribe, Idaho Power Company, and U. S. Fish and Wildlife Service. Our objective for this report was to consolidate the findings from annual redd searches into a single document containing detailed information about the searches from the most recent spawning season, and summary information from previous years. The work conducted in 2002 was funded by the Bonneville Power Administration (Projects 1998-01-003 and 1994-03-400) and the Idaho Power Company.« less

NASA/ASEE Summer Faculty Fellowship Program: 1988 research reports

NASA Technical Reports Server (NTRS)

Anderson, Loren A. (Editor); Armstrong, Dennis W. (Editor)

1988-01-01

This contractor's report contains all sixteen final reports prepared by the participants in the 1988 Summer Faculty Fellowship Program. Reports describe research projects on a number of topics including controlled environments, robotics, cryogenic propellant storage, polymers, hydroponic culture, adaptive servocontrol, and computer aided design

Environmental Impact Statement. Volume 1. Proposed High Frequency Active Auroral Research Program

DTIC Science & Technology

1993-07-01

Proposed HAARP Facility and Potential Borrow Areas P-1 & P-2 Cultural Resources Survey Areas, 1988 - 1990 ....... 3-97 3.9-3 Potential Borrow Area A -1...Cultural Resou Survey Areas 1988 ..... 3-99 3.9-4 Potential Borrow Area A -4 Cultural Resource Survey Areas 1988 ...... 3-101 3.9-5 Potential Borrow Area A -5...1987 (5 holes) and 1988 (2 holes) (USACOE, 1987a; 1988 ), and a series of additional borings conducted in 1989 (Moolin and Associates, 1989). These

Malignancies in children and young adults on etanercept: summary of cases from clinical trials and post marketing reports

PubMed Central

2013-01-01

Background Malignancy risk may be increased in chronic inflammatory conditions that are mediated by tumor necrosis factor (TNF), such as juvenile idiopathic arthritis (JIA), but the role of TNF in human cancer biology is unclear. In response to a 2011 United States Food & Drug Administration requirement of TNF blocker manufacturers, we evaluated reporting rates of all malignancies in patients ≤30 years old who received the TNF blocker etanercept. Methods All malignancies in etanercept-exposed patients aged ≤30 years from the Amgen clinical trial database (CTD) and postmarketing global safety database (PMD) were reviewed. PMD reporting rates were generated using exposure information based on commercial sources. Age-specific incidence rates of malignancy for the general US population were generated from the Surveillance Epidemiology and End Results (SEER) database v7.0.9. Results There were 2 malignancies in the CTD: 1 each in etanercept and placebo/comparator arms (both in patients 18–30 years old). Postmarketing etanercept exposure was 231,404 patient-years (62,379 patient-years in patients 0–17 years; 168,485 patient-years in patients 18–30 years). Reporting rates of malignancy per 100,000 patient-years in the PMD and incidence rates in SEER were 32.0 and 15.9, respectively, for patients 0–17 years and 46.9 and 42.1 for patients 18–30 years old. Reporting rates were higher than SEER incidence rates for Hodgkin lymphoma in the 0-17 years age group. PMD reporting rates per 100,000 patient-years and SEER incidence rates per 100,000 person-years for Hodgkin lymphoma were 9.54 and 0.9, respectively, for patients 0–17 years and 1.8 and 4.2 for patients 18–30 years old. There were ≥5 cases of leukemia, lymphoma, melanoma, thyroid, and cervical cancers. Leukemia, non-Hodgkin lymphoma, melanoma, thyroid cancer, and cervical cancer rates were similar in the PMD and SEER. Conclusions Overall PMD malignancy reporting rates in etanercept-treated patients 0–17 years appeared higher than incidence rates in SEER, attributable to rates of Hodgkin lymphoma. Comparison to patients with similar burden of disease cannot be made; JIA, particularly very active disease, may be a risk factor for lymphoma. No increased malignancy reporting rate in the PMD relative to SEER was observed in the young-adult age group. PMID:24225257

Status of the flora and fauna on the Nevada Test Site, 1988. Results of continuing basic environmental monitoring, January--December 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunter, R.B.

1992-06-01

In 1987 the US Department of Energy (DOE) initiated a program to monitor the health of the Nevada Test Site (NTS) plants and animals in support of the National Environmental Protection Act. The program, part of DOE`s Basic Environmental Compliance and Monitoring Program (BECAMP), monitors perennial and ephemeral plants, the more common species of rodents and lizards, and the horses, deer, raptors and other large animals on the NTS. This is a report of data collected on these flora and fauna for the year 1988, the second year of monitoring.

The Bradford Papers Annual, Volume III, 1988.

ERIC Educational Resources Information Center

Robb, Gary M., Ed.

This annual collection promotes scholarly writing, applied research findings, and innovative programs and activities in experiential education. Topics of the 1988 papers include (1) "Gender Issues in Outdoor Adventure Programming" (Natalie L. Bartley and Daniel R. Williams) about the effects of outdoor leaders' gender, personality, soft skills…

NATIONAL SURVEY OF WIC PARTICIPANTS (NSWP)

EPA Science Inventory

The NSWP was the first national survey of WIC enrollees since 1988. Over that ten-year period, the WIC program vastly expanded, with the number of enrollees growing from approximately 3.4 million in 1988 to over 8 million in 1998. The Special Supplemental Nutrition Program for Wo...

Is Welfare Reform Responsible for Low Skilled Women's Declining Health Insurance Coverage in the 1990s?

ERIC Educational Resources Information Center

DeLeire, Thomas; Levine, Judith A.; Levy, Helen

2006-01-01

We use data from the 1989-2001 March Supplements to the Current Population Survey to determine whether welfare reform contributed to declines in health insurance coverage experienced by low-skilled women. Between 1988 and 2000, women with less than a high school education experienced an 8.0 percentage point decline in the probability of having…

A Comparative Analysis of Word Problems in Selected United States and Russian First Grade Textbooks

ERIC Educational Resources Information Center

Grishchenko, Svetlana

2009-01-01

The purpose of this study was to explore word problems as a subject matter in mathematics textbook curricula. The motivation for the study derived from the following evidence: (a) American students find some word problems are more difficult than others (Garcia, Jimenez, & Hess, 2006; Riley & Green, 1988; Stern, 2001), and (b) one of the…

Catastrophic fires in Russian forests

Treesearch

A. I. Sukhinin; D. J. McRae; B. J. Stocks; S. G. Conard; WeiMin Hao; A. J. Soja; D. Cahoon

2010-01-01

We evaluated the contribution of catastrophic fires to the total burned area and the amount of tree mortality in Russia since the 1970’s. Such fires occurred in the central regions of European Russia (1972, 1976, 1989, 2002, 2010), Khabarovsk krai (1976, 1988, 1998), Amur region (1997-2002), Republics of Yakutia and Tuva (2002), Magadan and Kamchatka oblast (1984, 2001...

Expanding the Private School Sector: Government Policy and Private Secondary Schools in Hong Kong, 1988-2001

ERIC Educational Resources Information Center

Cheung, Alan C. K.; Randall, E. Vance; Tam, Man-Kwan

2005-01-01

This paper addresses the extent to which government policy has helped increase the number and diversity of private secondary schools in Hong Kong, which, in turn, has expanded the options for parental choice. Five indicators were selected to measure this objective. They are as follows: (1) Number of private schools and students enrolled; (2) Types…

The Actualization of the Malaysian National Education Philosophy in Secondary Schools: Student and Teacher Perspectives

ERIC Educational Resources Information Center

Al-Hudawi, Shafeeq Hussain Vazhathodi; Fong, Rosy Lai Su; Musah, Mohammed Borhandden; Tahir, Lokman Mohd

2014-01-01

In the Malaysian context, all educational processes at the national level are envisioned by the National Education Philosophy (NEP). The NEP was formed in 1988 in line with the National Principles (Rukun Negara) with the ultimate aims of building a united and progressive society (Ministry of Education, 2001). However, there is uncertainty whether…

Cancer Incidence in the U.S. Military Population: Comparison with Rates from the SEER Program

DTIC Science & Technology

2009-06-08

reproductive his- tory such as age at first birth, parity, and use of contracep- tives. Military women may be more likely to use oral contraceptive ...analysis, 34% of active-duty women and 29% of women in the general population used oral contraceptive pills in the preceding 12 months. Oral... contraceptive pill use has been shown to increase the risk for breast cancer, particu- larly in younger women (33, 34). Military women are also more likely to

Healthcare experience among older cancer survivors: Analysis of the SEER-CAHPS dataset.

PubMed

Halpern, Michael T; Urato, Matthew P; Lines, Lisa M; Cohen, Julia B; Arora, Neeraj K; Kent, Erin E

2018-05-01

Little is known about factors affecting medical care experiences of cancer survivors. This study examined experience of care among cancer survivors and assessed associations of survivors' characteristics with their experience. We used a newly-developed, unique data resource, SEER-CAHPS (NCI's Surveillance Epidemiology and End Results [SEER] data linked to Medicare Consumer Assessment of Healthcare Providers and Systems [CAHPS] survey responses), to examine experiences of care among breast, colorectal, lung, and prostate cancer survivors age >66years who completed CAHPS >1year after cancer diagnosis and survived ≥1year after survey completion. Experience of care was assessed by survivor-provided scores for overall care, health plan, physicians, customer service, doctor communication, and aspects of care. Multivariable logistic regression models assessed associations of survivors' sociodemographic and clinical characteristics with care experience. Among 19,455 cancer survivors with SEER-CAHPS data, higher self-reported general-health status was significantly associated with better care experiences for breast, colorectal, and prostate cancer survivors. In contrast, better mental-health status was associated with better care experience for lung cancer survivors. College-educated and Asian survivors were less likely to indicate high scores for care experiences. Few differences in survivors' experiences were observed by sex or years since diagnosis. The SEER-CAHPS data resources allows assessment of factors influencing experience of cancer among U.S. cancer survivors. Higher self-reported health status was associated with better experiences of care; other survivors' characteristics also predicted care experience. Interventions to improve cancer survivors' health status, such as increased access to supportive care services, may improve experience of care. Copyright © 2017 Elsevier Ltd. All rights reserved.

Greater absolute risk for all subtypes of breast cancer in the US than Malaysia.

PubMed

Horne, Hisani N; Beena Devi, C R; Sung, Hyuna; Tang, Tieng Swee; Rosenberg, Philip S; Hewitt, Stephen M; Sherman, Mark E; Anderson, William F; Yang, Xiaohong R

2015-01-01

Hormone receptor (HR) negative breast cancers are relatively more common in low-risk than high-risk countries and/or populations. However, the absolute variations between these different populations are not well established given the limited number of cancer registries with incidence rate data by breast cancer subtype. We, therefore, used two unique population-based resources with molecular data to compare incidence rates for the 'intrinsic' breast cancer subtypes between a low-risk Asian population in Malaysia and high-risk non-Hispanic white population in the National Cancer Institute's surveillance, epidemiology, and end results 18 registries database (SEER 18). The intrinsic breast cancer subtypes were recapitulated with the joint expression of the HRs (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor-2 (HER2). Invasive breast cancer incidence rates overall were fivefold greater in SEER 18 than in Malaysia. The majority of breast cancers were HR-positive in SEER 18 and HR-negative in Malaysia. Notwithstanding the greater relative distribution for HR-negative cancers in Malaysia, there was a greater absolute risk for all subtypes in SEER 18; incidence rates were nearly 7-fold higher for HR-positive and 2-fold higher for HR-negative cancers in SEER 18. Despite the well-established relative breast cancer differences between low-risk and high-risk countries and/or populations, there was a greater absolute risk for HR-positive and HR-negative subtypes in the US than Malaysia. Additional analytical studies are sorely needed to determine the factors responsible for the elevated risk of all subtypes of breast cancer in high-risk countries like the United States.

Neuroblastoma among children in Southern and Eastern European cancer registries: Variations in incidence and temporal trends compared to US.

PubMed

Georgakis, Marios K; Dessypris, Nick; Baka, Margarita; Moschovi, Maria; Papadakis, Vassilios; Polychronopoulou, Sophia; Kourti, Maria; Hatzipantelis, Emmanuel; Stiakaki, Eftichia; Dana, Helen; Bouka, Evdoxia; Antunes, Luis; Bastos, Joana; Coza, Daniela; Demetriou, Anna; Agius, Domenic; Eser, Sultan; Gheorghiu, Raluca; Sekerija, Mario; Trojanowski, Maciej; Zagar, Tina; Zborovskaya, Anna; Ryzhov, Anton; Tragiannidis, Athanassios; Panagopoulou, Paraskevi; Steliarova-Foucher, Eva; Petridou, Eleni Th

2018-05-15

Neuroblastoma comprises the most common neoplasm during infancy (first year of life). Our study describes incidence of neuroblastoma in Southern-Eastern Europe (SEE), including - for the first time - the Nationwide Registry for Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST)/Greece, compared to the US population, while controlling for human development index (HDI). Age-adjusted incidence rates (AIR) were calculated for 1,859 childhood (0-14 years) neuroblastoma cases, retrieved from 13 collaborating SEE registries (1990-2016), and were compared to those of SEER/US (N = 3,166; 1990-2012); temporal trends were assessed using Poisson regression and Joinpoint analyses. The overall AIR was significantly lower in SEE (10.1/million) compared to SEER (11.7 per million); the difference was maximum during infancy (43.7 vs. 53.3 per million, respectively), when approximately one-third of cases were diagnosed. Incidence rates of neuroblastoma at ages <1 and 1-4 years were positively associated with HDI, whereas lower median age at diagnosis was correlated with higher overall AIR. Distribution of primary site and histology was similar in SEE and SEER. Neuroblastoma was slightly more common among males compared to females (male-to-female ratio: 1.1), mainly among SEE infants. Incidence trends decreased in infants in Slovenia, Cyprus and SEER and increased in Ukraine and Belarus. The lower incidence in SEE compared to SEER, especially in infants living in low HDI countries possibly indicates a lower level of overdiagnosis in SEE. Hence, increases in incidence rates in infancy noted in some subpopulations should be carefully monitored to avoid the unnecessary costs health impacts of tumors that could potentially spontaneously regress. © 2017 UICC.

Incidence and time trends of childhood lymphomas: findings from 14 Southern and Eastern European cancer registries and the Surveillance, Epidemiology and End Results, USA.

PubMed

Georgakis, Marios K; Karalexi, Maria A; Agius, Domenic; Antunes, Luis; Bastos, Joana; Coza, Daniela; Demetriou, Anna; Dimitrova, Nadya; Eser, Sultan; Florea, Margareta; Ryzhov, Anton; Sekerija, Mario; Žagar, Tina; Zborovskaya, Anna; Zivkovic, Snezana; Bouka, Evdoxia; Kanavidis, Prodromos; Dana, Helen; Hatzipantelis, Emmanuel; Kourti, Maria; Moschovi, Maria; Polychronopoulou, Sophia; Stiakaki, Eftichia; Kantzanou, Μaria; Pourtsidis, Apostolos; Petridou, Eleni Th

2016-11-01

To describe epidemiologic patterns of childhood (0-14 years) lymphomas in the Southern and Eastern European (SEE) region in comparison with the Surveillance, Epidemiology and End Results (SEER), USA, and explore tentative discrepancies. Childhood lymphomas were retrieved from 14 SEE registries (n = 4,702) and SEER (n = 4,416), diagnosed during 1990-2014; incidence rates were estimated and time trends were evaluated. Overall age-adjusted incidence rate was higher in SEE (16.9/10 6 ) compared to SEER (13.6/10 6 ), because of a higher incidence of Hodgkin (HL, 7.5/10 6 vs. 5.1/10 6 ) and Burkitt lymphoma (BL, 3.1 vs. 2.3/10 6 ), whereas the incidence of non-Hodgkin lymphoma (NHL) was overall identical (5.9/10 6 vs. 5.8/10 6 ), albeit variable among SEE. Incidence increased with age, except for BL which peaked at 4 years; HL in SEE also showed an early male-specific peak at 4 years. The male preponderance was more pronounced for BL and attenuated with increasing age for HL. Increasing trends were noted in SEER for total lymphomas and NHL, and was marginal for HL, as contrasted to the decreasing HL and NHL trends generally observed in SEE registries, with the exception of increasing HL incidence in Portugal; of note, BL incidence trend followed a male-specific increasing trend in SEE. Registry-based data reveal variable patterns and time trends of childhood lymphomas in SEE and SEER during the last decades, possibly reflecting diverse levels of socioeconomic development of the populations in the respective areas; optimization of registration process may allow further exploration of molecular characteristics of disease subtypes.

Research and technology plans for FY 1989 and accomplishments for FY 1988. [Structural Mechanics Division

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1989-01-01

The Objectives, FY 1989 Plans, Approach, and FY 1989 Milestones for the Structural Mechanics Division's research programs are presented. Fiscal year 1988 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Public-Private Partnership Program Evaluation. 1988-89.

ERIC Educational Resources Information Center

Bland, June

This evaluation of the 1988-89 Public Private Partnership (PPP) program in Washington (District of Columbia) was seriously limited by the unavailability of statistical data on student progress and internship performance. PPP was designed to improve the preparation of high school students for the world of work by involving community businesses in…

77 FR 31359 - Medicare and Medicaid Programs; Announcement of the Re-Approval of the Joint Commission as an...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... Organization Under the Clinical Laboratory Improvement Amendments of 1988 AGENCY: Centers for Medicare... Commission for re-approval as an accreditation organization for clinical laboratories under the Clinical... On October 31, 1988, the Congress enacted the Clinical Laboratory Improvement Amendments of 1988...

The U.S. Geological Survey Federal-State Cooperative Water- Resources Program: Fiscal Year 1988

USGS Publications Warehouse

Gilbert, Bruce K.; Mann, William B.

1989-01-01

The Federal-State Cooperative Program is a partnership between the U.S. Geological Survey and State and local agencies. It provides a balanced approach to the study and resolution of water-related problems and to acquiring hydrologic data. The principal program objectives are to: (1) collect, on a systematic basis, data needed for the continuing determination and evaluation of the quantity, quality, and use of the Nation's water resources, and (2) appraise the availability and the physical, chemical, and biological characteristics of surface and ground water through analytical and interpretive investigations. During fiscal year 1988, hydrologic data collection, interpretive investigations, and research were conducted by Geological Survey personnel in offices in every State, Puerto Rico, and several territories in cooperation with more than 1,000 local, State, and regional agencies. In fiscal year 1988, Federal funding of almost $60 million was matched by cooperating agencies, who also provided approximately $6 million unmatched for a total program of about $126 million. This amounted to more than 40 percent of the total funds for Geological Survey water-resources activities. This report presents examples of current (1988) investigations. It also lists about 250 water-resources investigations related to agricultural activities that the Geological Survey conducted from 1970 to 1988.

Risk of second malignancies in patients with early-stage classical Hodgkin's lymphoma treated in a modern era.

PubMed

LeMieux, Melissa H; Solanki, Abhishek A; Mahmood, Usama; Chmura, Steven J; Koshy, Matthew

2015-04-01

Second malignancies remain an issue affecting morbidity and mortality in long-term survivors of early stage Hodgkin's lymphoma (HL). We undertook this study to determine if treatment in the modern era resulted in decreased second malignancies. Patients diagnosed with stage I-II cHL between 1988 and 2009 who received radiation therapy (RT) were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Freedom from second malignancy (FFSM) was estimated using the Kaplan-Meier method. Univariate analysis (UVA) was performed using the Log-Rank test, and included age, gender, year of diagnosis, and stage. Multivariable analysis (MVA) was performed using Cox Proportional Hazards modeling. The study cohort included 8807 patients. The median age at diagnosis was 32 years (range: 2-85). The majority of patients had stage II disease (n = 6044, 69%), 597 (7%) had extranodal involvement (ENI), and 1925 (22%) had B symptoms. Median follow-up for the entire cohort was 7.2 years (range: 0-22). Five hundred twenty-three (6%) patients developed a second malignancy. Median latency to second malignancy was 5.8 years (range: 0.1-21.5). Of the 523 patients that developed a second malignancy, 228 (44%) occurred in the first 5 years, 139 (27%) were diagnosed between years 5-10, and 156 (30%) beyond 10 years. The 10 year FFSM for patients treated between 1988 and 1999 was 93.0% versus 95.1% for patients treated between 2000 and 2009 (P = 0.04), On MVA, treatment between 2000 and 2009 was associated with a HR for second malignancy of 0.77 (95% Confidence Interval: 0.62-0.96, P = 0.02) compared to the treatment between 1988 and 1999. Our analysis suggests that in patients treated with RT for stage I or II cHL, treatment prior to 2000 had a slightly higher risk of second malignancy compared to treatment in 2000 and later. Further studies, with longer follow-up of patients treated in the modern era are needed to confirm these findings. © 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Summer Research Program (1992). Graduate Student Research Program (GSRP) Reports. Volume 10. Wright Laboratory

DTIC Science & Technology

1992-12-28

used because the stress and displacement field equations can be found for that type of nonhomogeneity (Delale and Erdogan , 1988) . The number of...nonhomogeneous interphase striýps (exponentiýal case) are given by Delale and Erdogan , 1988. u K ) 2 f ( _2 𔃼( 7 ) -x _+_2(n + C,(T l -l2 1~~M 2 rii 2...E.P. Pluddemann, editor, Comp. Mats. •, 32-77. Academic Press, New York. Delale, F. and Erdogan , F (1988). On the Mechanical Modeling of the

Survival of aggressive variants of papillary thyroid carcinoma in patients under 55 years old: a SEER population-based retrospective analysis.

PubMed

Feng, Jianhua; Shen, Fei; Cai, Wensong; Gan, Xiaoxiong; Deng, Xingyan; Xu, Bo

2018-06-16

Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. All adult patients (<55 years old) with DSV, TCV and conventional PTC (CPTC) came from the Surveillance, Epidemiology, and End Results program (1988-2013). Kaplan-Meier method and log-rank test were used to analyze the survival. Prognostic factors associated with survival were analyzed by Cox multivariate regression. There were 280 DSV, 615 TCV, and 56287 CPTC in the age group <55 years. DSV and TCV were associated with multifocality, extrathyroidal extension, lymph node and distant metastasis (all p < 0.05). The 10-year disease-specific survival (DSS) of TCV was worse than CPTC (96.3 vs. 99.4%, p < 0.01), but there was no significant difference between DSV and CPTC (99.5 vs. 99.4%, p > 0.05). Cox multivariate regression showed TCV was the independent predictor of DSS (HR: 5.39, p < 0.01). In the age group <55 years, DSV and TCV are more likely to exhibit aggressive characteristics than CPTC. Patient <55 years of age with DSV have excellent survival likewise, while patients <55 years of age with TCV carry worse survival. Further investigation for the recurrence risk of patients <55 years with these variants would contribute to optimal clinical management making.

NASA's Education Program Inventory FY 91

NASA Technical Reports Server (NTRS)

1992-01-01

In 1988, the Education Division produced an inventory of NASA-supported education programs. Since then, mathematics, science, and technology education has taken on a more visible role, not only as part of NASA's mission, but as part of the National Education Goals and other Federal initiatives. Therefore, it became important to update the 1988 inventory in order to achieve a more accurate and comprehensive look at NASA's educational programs. The data collected is summarized and descriptions of each program are provided.

Past, present and future of colorectal cancer in the Kingdom of Saudi Arabia.

PubMed

Ibrahim, Ezzeldin M; Zeeneldin, Ahmed A; El-Khodary, Tawfik R; Al-Gahmi, Aboelkhair M; Bin Sadiq, Bakr M

2008-10-01

The crude frequency of colorectal cancer (CRC) is second to breast cancer in the Kingdom of Saudi Arabia (KSA). To assess the future burden of CRC in the country, we designed a model that takes into consideration the recent lifestyle pattern and the growth and aging of the population. We compared CRC statistics for KSA (using data from the National Cancer Registry) with that from the Surveillance, Epidemiology and End Results (SEER) databases of the United States of America (USA). We used the Joinpoint regression program to identify changes in secular trends, while the GLOBOCAN 2002 software was used to project future incidence and mortality. Between 1994 and 2003, age-standardized rates (ASRs) for CRC in KSA almost doubled, as compared to a nonsignificant decline in USA. Between 2001 and 2003, while the annual percent change (APC) of CRC incidence in the USA showed a nonsignificant decrease in females, APC in Saudi females showed a nonsignificant rise of six percent. On the other hand, the rising incidence among Saudi males, during the years 1999 to 2003, was significant, with an APC of 20.5%. The projection model suggested that the incidence of CRC in KSA could increase fourfold in both genders by the year 2030. In KSA, the present and expected increase in CRC rates is alarming. Pragmatic recommendations to face that challenge are discussed. The present work could serve as a model to study other prevalent types of cancer, particularly in developing countries.

Development Achievements at Pittsburg State University for Fiscal Year 1988.

ERIC Educational Resources Information Center

Smoot, Joseph G.

The development report for Pittsburg State University's (PSU) fiscal year 1988 is presented. The most important objective of PSU's development program is to provide funding beyond the state support in order to distinguish the university among its U.S. peers. Chapters include an overview of FY 1988 development activities, the Annual Fund, the…

75 FR 63524 - Computer Matching and Privacy Protection Act of 1988; Report of Matching Program: RRB and State...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... RAILROAD RETIREMENT BOARD Computer Matching and Privacy Protection Act of 1988; Report of Matching... Railroad Retirement Act. SUMMARY: As required by the Computer Matching and Privacy Protection Act of [[Page...: Under certain circumstances, the Computer Matching and Privacy Protection Act of 1988, Public Law 100...

Nursing Predictors Study, Phase One.

ERIC Educational Resources Information Center

Dean, Janet H.; Fischer, Susanne E.

In an effort to identify the minimum qualifications necessary for an entering student to succeed in a selective admission Nursing Program at Saint Petersburg Junior College in Florida, a study was conducted of 424 generic nursing students who started the program in January 1988, August 1988, January 1989, and August 1989. A successful student was…

Legislative Studies in State Education Policy, 1976-1988: A Final Summary.

ERIC Educational Resources Information Center

National Conference of State Legislatures, Denver, CO.

During the period from 1976 through 1988, the National Conference of State Legislatures and the United States Department of Education's Office of Educational Research and Improvement collaborated to develop a program supporting educational policy studies for state legislatures. The program contributed 69 studies on a variety of topics. This report…

Implementing PICKUP in LEA Colleges under the Education Reform Act 1988. A Guidance Manual.

ERIC Educational Resources Information Center

Thomas, David

This manual on the provision of Professional, Industrial, and Commercial Updating (PICKUP) programming by colleges in England, Scotland, and Wales consists of a summary of recommendations, an introduction, 8 sections, and 11 appendices. Section 1 discusses planning; the requirements of the 1988 Education Reform Act; provision of programming;…

1988 Underground Storage Tanks; Technical Requirements; Final Rule and Underground Storage Tanks Containing Petroleum-Financial Responsibility Requirements and State Program Approval Objective; Final Rule

EPA Pesticide Factsheets

EPA's 1988 regulations concerning USTs are contained in 40 CFR Part 280, 40 CFR Part 281 and 40 CFR Parts 282.50-282.105 and divided into three sections: technical requirements, financial responsibility requirements, and state program approval objectives.

The Changing Association between Prenatal Participation in WIC and Birth Outcomes in New York City

ERIC Educational Resources Information Center

Joyce, Ted; Gibson, Diane; Colman, Silvie

2005-01-01

We analyze the relationship between prenatal WIC participation and birth outcomes in New York City from 1988 - 2001. The analysis is unique for several reasons. First, we have over 800,000 births to women on Medicaid, the largest sample ever used to analyze prenatal participation in WIC. Second, we focus on measures of fetal growth distinct from…

Trends and variability in column-integrated atmospheric water vapor

NASA Astrophysics Data System (ADS)

Trenberth, Kevin E.; Fasullo, John; Smith, Lesley

2005-06-01

An analysis and evaluation has been performed of global datasets on column-integrated water vapor (precipitable water). For years before 1996, the Ross and Elliott radiosonde dataset is used for validation of European Centre for Medium-range Weather Forecasts (ECMWF) reanalyses ERA-40. Only the special sensor microwave imager (SSM/I) dataset from remote sensing systems (RSS) has credible means, variability and trends for the oceans, but it is available only for the post-1988 period. Major problems are found in the means, variability and trends from 1988 to 2001 for both reanalyses from National Centers for Environmental Prediction (NCEP) and the ERA-40 reanalysis over the oceans, and for the NASA water vapor project (NVAP) dataset more generally. NCEP and ERA-40 values are reasonable over land where constrained by radiosondes. Accordingly, users of these data should take great care in accepting results as real. The problems highlight the need for reprocessing of data, as has been done by RSS, and reanalyses that adequately take account of the changing observing system. Precipitable water variability for 1988 2001 is dominated by the evolution of ENSO and especially the structures that occurred during and following the 1997 98 El Niño event. The evidence from SSM/I for the global ocean suggests that recent trends in precipitable water are generally positive and, for 1988 through 2003, average 0.40±0.09 mm per decade or 1.3±0.3% per decade for the ocean as a whole, where the error bars are 95% confidence intervals. Over the oceans, the precipitable water variability relates very strongly to changes in SSTs, both in terms of spatial structure of trends and temporal variability (with a regression coefficient for 30°N 30°S of 7.8% K-1) and is consistent with the assumption of fairly constant relative humidity. In the tropics, the trends are also influenced by changes in rainfall which, in turn, are closely associated with the mean flow and convergence of moisture by the trade winds. The main region where positive trends are not very evident is over Europe, in spite of large and positive trends over the North Atlantic since 1988. A much longer time series is probably required to obtain stable patterns of trends over the oceans, although the main variability could probably be deduced from past SST and associated precipitation variations.

Outpatient care programs of mental health organizations, United States, 1988.

PubMed

Redick, R W; Witkin, M J; Atay, J E; Manderscheid, R W

1991-09-01

In 1988, 2,989 (60 percent) of the 4,961 mental health organizations in the United States (including the territories) offered outpatient care programs. A total of 5.8 million patient care episodes were generated by these organized outpatient programs. These episodes included 3.1 million outpatient additions, produced 54 million outpatient visits, and represented 67 percent of all patient care episodes in mental health organizations in 1988. Although the number of mental health organizations with outpatient care programs increased by less than one percent between 1986 and 1988, the number of outpatient additions showed an 11 percent gain during this period. Multiservice mental health organizations were the primary locus of outpatient care in 1988, accounting for 41 percent of the 2,989 mental health organizations providing this care. Ranking next in this respect, were free-standing psychiatric outpatient clinics, and the separate psychiatric outpatient services in non-Federal general hospitals, with 25 and 16 percent, respectively, of the total outpatient care programs. In general, these three organization types had similar rankings with respect to the volume of the outpatient caseload. By definition, all of the freestanding psychiatric outpatient clinics provided outpatient care, and almost all of the VA mental health programs and multiservice mental health organizations also offered this care (99 and 92 percent, respectively). In contrast, psychiatric outpatient care was available in only 37 percent of non-Federal general hospitals with separate psychiatric services, 36 percent of private psychiatric hospitals, 29 percent of State mental hospitals, and 22 percent of RTCs for emotionally disturbed children. Outpatient care was available in mental health organizations in all States in 1988, with every State having at least two or more organization types providing this service. In general, the most populous States had the largest number and the greatest variety of mental health organizations with outpatient care programs. Of the 2.87 million clients receiving outpatient care in mental health organizations at the end of 1988, 23 percent were under 18 years of age, 68 percent were 18 to 64, and 9 percent were 65 and older. Male outpatient clients slightly outnumbered female clients. The majority (77 percent) of the outpatient clients were white, with blacks representing 21 percent; native Americans and Asians/Pacific Islanders, the remaining two percent. Eleven percent of the total client population were reported to be of Hispanic origin.(ABSTRACT TRUNCATED AT 400 WORDS)

Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma.

PubMed

Megwalu, Uchechukwu C; Sirjani, Davud

2017-04-01

Objective To determine the risk of nodal metastasis, examine risk factors for nodal metastasis, and evaluate the impact of nodal metastasis on survival in patients with major salivary gland adenoid cystic carcinoma. Study Design Retrospective cohort study from a large population- based cancer database. Methods Data were extracted from the SEER 18 database (Surveillance, Epidemiology, and End Results) of the National Cancer Institute. The study cohort included 720 patients diagnosed with major salivary gland adenoid cystic carcinoma between 1988 and 2013. Results The overall rate of lymph node metastasis was 17%. T3 disease (odds ratio, 4.74) and T4 disease (odds ratio, 9.24) were associated with increased risk of nodal metastasis. Age, sex, and site were not associated with nodal metastasis. Nodal metastasis was associated with worse overall survival (hazard ratio, 2.56) and disease-specific survival (hazard ratio, 3.27), after adjusting for T stage, presence of distant metastasis, site, surgical resection, radiotherapy, neck dissection, age, sex, race, marital status, and year of diagnosis. Conclusion Major salivary gland adenoid cystic carcinoma carries significant risk of nodal metastasis. Advanced T stage is associated with increased risk of nodal metastasis. Nodal metastasis is associated with worse survival.

Our Graduates: More Than a Product. Class of 1988.

ERIC Educational Resources Information Center

Muzeroll, Terry

A study was conducted at Connecticut's Middlesex Community College (MxCC) to develop a profile of the college's 1988 graduates in terms of program area, age, sex, student status, attendance patterns, and grade point average (GPA). Study findings about the 272 graduates included the following: (1) the number of graduates was higher in 1988 than in…

NFDRSPC: The National Fire-Danger Rating System on a Personal Computer

Treesearch

Bryan G. Donaldson; James T. Paul

1990-01-01

This user's guide is an introductory manual for using the 1988 version (Burgan 1988) of the National Fire-Danger Rating System on an IBM PC or compatible computer. NFDRSPC is a window-oriented, interactive computer program that processes observed and forecast weather with fuels data to produce NFDRS indices. Other program features include user-designed display...

Small Business Innovation Research. Program solicitation. Closing date: July 22, 1988

NASA Technical Reports Server (NTRS)

1988-01-01

The sixth annual Small Business Innovation Research (SBIR) solicitation by NASA, describes the program, identifies eligibility requirements, outlines proposal preparation and submission requirements, describes the proposal evaluation and award selection process, and provides other information to assist those interested in participating in the SBIR program. It also identifies in Section 8.0 and Appendix D, the specific technical topics and subtopics in which SBIR Phase 1 proposals are solicited in 1988.

Immortal time bias: a frequently unrecognized threat to validity in the evaluation of postoperative radiotherapy.

PubMed

Park, Henry S; Gross, Cary P; Makarov, Danil V; Yu, James B

2012-08-01

To evaluate the influence of immortal time bias on observational cohort studies of postoperative radiotherapy (PORT) and the effectiveness of sequential landmark analysis to account for this bias. First, we reviewed previous studies of the Surveillance, Epidemiology, and End Results (SEER) database to determine how frequently this bias was considered. Second, we used SEER to select three tumor types (glioblastoma multiforme, Stage IA-IVM0 gastric adenocarcinoma, and Stage II-III rectal carcinoma) for which prospective trials demonstrated an improvement in survival associated with PORT. For each tumor type, we calculated conditional survivals and adjusted hazard ratios of PORT vs. postoperative observation cohorts while restricting the sample at sequential monthly landmarks. Sixty-two percent of previous SEER publications evaluating PORT failed to use a landmark analysis. As expected, delivery of PORT for all three tumor types was associated with improved survival, with the largest associated benefit favoring PORT when all patients were included regardless of survival. Preselecting a cohort with a longer minimum survival sequentially diminished the apparent benefit of PORT. Although the majority of previous SEER articles do not correct for it, immortal time bias leads to altered estimates of PORT effectiveness, which are very sensitive to landmark selection. We suggest the routine use of sequential landmark analysis to account for this bias. Copyright © 2012 Elsevier Inc. All rights reserved.

Immortal Time Bias: A Frequently Unrecognized Threat to Validity in the Evaluation of Postoperative Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Henry S.; Gross, Cary P.; Makarov, Danil V.

2012-08-01

Purpose: To evaluate the influence of immortal time bias on observational cohort studies of postoperative radiotherapy (PORT) and the effectiveness of sequential landmark analysis to account for this bias. Methods and Materials: First, we reviewed previous studies of the Surveillance, Epidemiology, and End Results (SEER) database to determine how frequently this bias was considered. Second, we used SEER to select three tumor types (glioblastoma multiforme, Stage IA-IVM0 gastric adenocarcinoma, and Stage II-III rectal carcinoma) for which prospective trials demonstrated an improvement in survival associated with PORT. For each tumor type, we calculated conditional survivals and adjusted hazard ratios of PORTmore » vs. postoperative observation cohorts while restricting the sample at sequential monthly landmarks. Results: Sixty-two percent of previous SEER publications evaluating PORT failed to use a landmark analysis. As expected, delivery of PORT for all three tumor types was associated with improved survival, with the largest associated benefit favoring PORT when all patients were included regardless of survival. Preselecting a cohort with a longer minimum survival sequentially diminished the apparent benefit of PORT. Conclusions: Although the majority of previous SEER articles do not correct for it, immortal time bias leads to altered estimates of PORT effectiveness, which are very sensitive to landmark selection. We suggest the routine use of sequential landmark analysis to account for this bias.« less

Adjuvant Brachytherapy Removes Survival Disadvantage of Local Disease Extension in Stage IIIC Endometrial Cancer: A SEER Registry Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rossi, Peter J.; Jani, Ashesh B.; Horowitz, Ira R.

2008-01-01

Purpose: To assess the role of radiotherapy (RT) in women with Stage IIIC endometrial cancer. Methods and Materials: The 17-registry Survival, Epidemiology, and End Results (SEER) database was searched for patients with lymph node-positive non-Stage IV epithelial endometrial cancer diagnosed and treated between 1988 and 1998. Two subgroups were identified: those with organ-confined Stage IIIC endometrial cancer and those with Stage IIIC endometrial cancer with direct extension of the primary tumor. RT was coded as external beam RT (EBRT) or brachytherapy (BT). Observed survival (OS) was reported with a minimum of 5 years of follow-up; the survival curves were comparedmore » using the log-rank test. Results: The therapy data revealed 611 women with Stage IIIC endometrial cancer during this period. Of these women, 51% were treated with adjuvant EBRT, 21% with EBRT and BT, and 28% with no additional RT (NAT). Of the 611 patients, 293 had organ-confined Stage IIIC endometrial cancer and 318 patients had Stage IIIC endometrial cancer with direct extension of the primary tumor. The 5-year OS rate for all patients was 40% with NAT, 56% after EBRT, and 64% after EBRT/BT. Adjuvant RT improved survival compared with NAT (p <0.001). In patients with organ-confined Stage IIIC endometrial cancer, the 5-year OS rate was 50% for NAT, 64% for EBRT, and 67% for EBRT/BT. Again, adjuvant RT contributed to improved survival compared with NAT (p = 0.02). In patients with Stage IIIC endometrial cancer and direct tumor extension, the 5-year OS rate was 34% for NAT, 47% for EBRT, and 63% for EBRT/BT. RT improved OS compared with NAT (p <0.001). Also, in this high-risk subgroup, adding BT to EBRT was superior to EBRT alone (p = 0.002). Conclusion: Women with Stage IIIC endometrial cancer receiving adjuvant EBRT and EBRT/BT had improved OS compared with patients receiving NAT. When direct extension of the primary tumor was present, the addition of BT to EBRT was even more beneficial.« less

Adjuvant brachytherapy removes survival disadvantage of local disease extension in stage IIIC endometrial cancer: a SEER registry analysis.

PubMed

Rossi, Peter J; Jani, Ashesh B; Horowitz, Ira R; Johnstone, Peter A S

2008-01-01

To assess the role of radiotherapy (RT) in women with Stage IIIC endometrial cancer. The 17-registry Survival, Epidemiology, and End Results (SEER) database was searched for patients with lymph node-positive non-Stage IV epithelial endometrial cancer diagnosed and treated between 1988 and 1998. Two subgroups were identified: those with organ-confined Stage IIIC endometrial cancer and those with Stage IIIC endometrial cancer with direct extension of the primary tumor. RT was coded as external beam RT (EBRT) or brachytherapy (BT). Observed survival (OS) was reported with a minimum of 5 years of follow-up; the survival curves were compared using the log-rank test. The therapy data revealed 611 women with Stage IIIC endometrial cancer during this period. Of these women, 51% were treated with adjuvant EBRT, 21% with EBRT and BT, and 28% with no additional RT (NAT). Of the 611 patients, 293 had organ-confined Stage IIIC endometrial cancer and 318 patients had Stage IIIC endometrial cancer with direct extension of the primary tumor. The 5-year OS rate for all patients was 40% with NAT, 56% after EBRT, and 64% after EBRT/BT. Adjuvant RT improved survival compared with NAT (p <0.001). In patients with organ-confined Stage IIIC endometrial cancer, the 5-year OS rate was 50% for NAT, 64% for EBRT, and 67% for EBRT/BT. Again, adjuvant RT contributed to improved survival compared with NAT (p = 0.02). In patients with Stage IIIC endometrial cancer and direct tumor extension, the 5-year OS rate was 34% for NAT, 47% for EBRT, and 63% for EBRT/BT. RT improved OS compared with NAT (p <0.001). Also, in this high-risk subgroup, adding BT to EBRT was superior to EBRT alone (p = 0.002). Women with Stage IIIC endometrial cancer receiving adjuvant EBRT and EBRT/BT had improved OS compared with patients receiving NAT. When direct extension of the primary tumor was present, the addition of BT to EBRT was even more beneficial.

Asteroid Lightcurve Analysis at the Palmer Divide Observatory: 2011 December - 2012 March

NASA Astrophysics Data System (ADS)

Warner, Brian D.

2012-07-01

Lightcurves for 41 asteroids were obtained at the Palmer Divide Observatory (PDO) from 2011 December to 2012 March: 77 Frigga, 2933 Amber, 3352 McAuliffe, 3483 Svetlov, 4031 Mueller, 5378 Ellyett, 5579 Uhlherr, 5771 Somerville, 6087 Lupo, 6602 Gilclark, (6618) 1936 SO, 6635 Zuber, (8404) 1995 AN, (9873) 1992 GH, (11058) 1991 PN10, (16421) 1988 BJ, (16426) 1988 EC, (16585) 1992 QR, 16589 Hastrup, 18368 Flandrau, (19537) 1999 JL8, (23974) 1999 CK12, (24465) 2000 SX155, (26383) 1999 MA2, (30856) 1991 XE, (39618) 1994 LT, (45898) 2000 XQ49, (47983) 2000 XX13, (49566) 1999 CM106, (49678) 1999 TQ7, (50991) 2000 GK94, (57739) 2001 UF162, (63260) 2001 CN, (69350) 1993 YP, 79316 Huangshan, (82066) 2000 XG15, (82078) 2001 AH46, (105155) 2000 NG26, (141018) 2001 WC47, (256700) 2008 AG3, (320125) 2007 EQ185. Two asteroids showed indications of being binary. Analysis of the data for near-Earth asteroid, 3352 McAuliffe showed a second period of 20.86 h but no obvious mutual events (occultations and/or eclipses). The Hungaria asteroid, (24465) 2000 SX15, displayed similar characteristics. Furthermore, the primary (or only) period of 3.256 h cannot be reconciled with analysis from previous apparitions. Three asteroids showed signs of being in non-principal axis rotation (NPAR, "tumbling"). New values for absolute magnitude (H) were found for several Hungaria asteroids using either derived or assumed values of G. These new values were compared against those used in the WISE mission to determine diameters and albedos. In all cases where the WISE results featured an unusually high albedo for the asteroid in question, the new value of H resulted in an albedo that was significantly lower and closer to the expected value for type E asteroids, which are the likely members of the Hungaria collisional family.

44 CFR 63.3 - Requirement to be covered by a contract for flood insurance by June 1, 1988.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.3 Requirement to be covered by a contract for flood insurance by June 1, 1988... a contract for flood insurance by June 1, 1988. 63.3 Section 63.3 Emergency Management and...

44 CFR 63.3 - Requirement to be covered by a contract for flood insurance by June 1, 1988.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.3 Requirement to be covered by a contract for flood insurance by June 1, 1988... a contract for flood insurance by June 1, 1988. 63.3 Section 63.3 Emergency Management and...

44 CFR 63.3 - Requirement to be covered by a contract for flood insurance by June 1, 1988.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.3 Requirement to be covered by a contract for flood insurance by June 1, 1988... a contract for flood insurance by June 1, 1988. 63.3 Section 63.3 Emergency Management and...

44 CFR 63.3 - Requirement to be covered by a contract for flood insurance by June 1, 1988.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63.3 Requirement to be covered by a contract for flood insurance by June 1, 1988... a contract for flood insurance by June 1, 1988. 63.3 Section 63.3 Emergency Management and...

Robust Sensitivity Analysis of Courses of Action Using an Additive Value Model

DTIC Science & Technology

2008-03-01

According to Clemen , sensitivity analysis answers, “What makes a difference in this decision?” (2001:175). Sensitivity analysis can also indicate...alternative to change. These models look for the new weighting that causes a specific alternative to rank above all others. 19 Barron and Schmidt first... Schmidt , 1988:123). A smaller objective function value indicates greater sensitivity. Wolters and Mareschal propose a similar approach using goal

Juvenile nasopharyngeal angiofibroma: a single institution study.

PubMed

Mistry, Rajesh C; Qureshi, Sajid S; Gupta, Shaikat; Gupta, Sameer

2005-01-01

Juvenile nasopharyngeal angiofibroma (JNA) is a rare tumor of adolescent males and there is a paucity of Indian studies on this subject. To present the experience of management of JNA at a single institution. This is a retrospective observational study of patients with JNA who presented at the Tata Memorial Hospital between May 1988 and August 2001. Thirty-two patients with JNA were treated in the study period. Since the time period was prolonged and diagnostic and therapeutic protocols had undergone many changes, the patients were divided into two groups, namely 1988-1996 and 1997-2001. The age distribution, disease patterns, management approaches and treatment outcomes of patients in the two groups were recorded. Statistical analyses were done using students 't' test and test for proportion. The mean age at presentation was 16 years and more than 90% of the patients had Stage III or IV disease. Preoperative embolization was carried out in 19 patients. The surgical approaches used were median maxillectomy, infratemporal fossa, transpalatal, maxillary swing and craniofacial approach. The recurrence rate, complete resection rate and cure rates were 12.5%, 41% and 63% respectively. Surgery is the mainstay of treatment of JNA. Preoperative embolization and newer surgical approaches result in less blood loss and complete resection. Aggressive re-resection should be done for resectable recurrences reserving radiotherapy for unresectable, recurrent/ residual disease.

Method of Electroporation for the Early Chick Embryo

NASA Astrophysics Data System (ADS)

Hatakeyama, Jun; Shimamura, Kenji

Chick embryos have long been one of the favored model systems in the field of embryology and developmental biology. Recent advances in the gene manipulation technologies (Muramatsu et al., 1997; Nakamura et al., 2004) make this model system even more attractive for the developmental biologists (see review by Stern, 2005). Thanks to its two dimensional geometry, easiness in accessibility and observation, and well-established fate maps (e.g. Couly and Le Douarin, 1988; Garcia-Martinez et al., 1993; Hatada and Stern, 1994; Psychoyos and Stern, 1996; Sawada and Aoyama, 1999; Cobos et al., 2001; Lopez-Sanchez et al., 2001; Redkar et al., 2001; Fernandez-Garre et al., 2002; Kimura et al., 2006; Matsushita et al., 2008), it has great advantages especially for studies at the early embryonic stages, such as the processes of gastrulation, neural induction, left-right patterning, etc. For such purposes, a whole embryo culture system, originally invented by Dennis A. T. New (New, 1955), and its derivatives (Flamme, 1987; Sundin and Eichele, 1992; Stern, 1993; Chapman et al., 2001) have been widely used.

Libraries and Learning: Helping People Grow. Colorado State Library & Adult Education Office 1988 Annual Report.

ERIC Educational Resources Information Center

Colorado State Dept. of Education, Denver.

The Colorado State Library and Adult Education Office describe the activities and accomplishments of various library programs and services throughout the state in 1988. One-page profiles highlight each program and list contact persons and telephone numbers. Some of the profiles are accompanied by a brief feature story that takes a closer look at…

Long-Term Follow-Up Study of Legal Tech Graduates, 1984-1988. Volume XVIII, No. 5.

ERIC Educational Resources Information Center

Lucas, John A.; Hildebrandt, Sharrie

In order to provide information for the 1989-90 program review at William Rainey Harper College (WRHC) and to fulfill American Bar Association accreditation guidelines, a long-term, follow-up study was conducted of all Legal Tech program alumni who graduated between 1984 and 1988. A telephone survey generated usable responses from 106 (73%) of the…

Gender Equity in Vocational Programs of the Comprehensive High Schools: A Status Report, 1988-1989.

ERIC Educational Resources Information Center

Brett, Leslie J.; And Others

This report describes the status of gender and race/ethnicity enrollments in vocational programs in Connecticut's comprehensive high schools. Data are based on a sample of nine representative schools in urban, rural, and suburban communities. Enrollment data for the 1988-89 school year are from the State Department of Education and represent eight…

Early Childhood Education, The Year in Review: A Look at 1988.

ERIC Educational Resources Information Center

Hymes, James L., Jr.

This is a report on the happenings in early childhood education in the United States in 1988. Contents focus on: (1) the week, the year, and the decade of the young child; (2) the proposed Act for Better Child Care Services; (3) other child care developments; (4) other early childhood programs; (5) growth of pre-kindergarten programs; (6) the need…

Chapter 4: Small Commercial and Residential Unitary and Split System HVAC Heating and Cooling Equipment-Efficiency Upgrade Evaluation Protocol. The Uniform Methods Project: Methods for Determining Energy Efficiency Savings for Specific Measures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurnik, Charles W; Jacobson, David; Metoyer, Jarred

The specific measure described here involves improving the overall efficiency in air-conditioning systems as a whole (compressor, evaporator, condenser, and supply fan). The efficiency rating is expressed as the energy efficiency ratio (EER), seasonal energy efficiency ratio (SEER), and integrated energy efficiency ratio (IEER). The higher the EER, SEER or IEER, the more efficient the unit is.

Health Insurance Affects Head and Neck Cancer Treatment Patterns and Outcomes.

PubMed

Inverso, Gino; Mahal, Brandon A; Aizer, Ayal A; Donoff, R Bruce; Chuang, Sung-Kiang

2016-06-01

The purpose of this study is to examine the effect of insurance coverage on stage of presentation, treatment, and survival of head and neck cancer (HNC). A retrospective study was conducted using the Surveillance, Epidemiology, and End Results (SEER) program to identify patients diagnosed with HNC. The primary variable of interest was insurance analyzed as a dichotomous variable: Patients were considered uninsured if they were classified as "uninsured" by SEER, whereas patients were considered insured if they were defined by SEER as "any Medicaid," "insured," or "insured/no specifics." The outcomes of interest were cancer stage at presentation (M0 vs M1), receipt of definitive treatment, and HNC-specific mortality (HNCSM). Multivariable logistic regression modeled the association between insurance status and stage at presentation, as well as between insurance status and receipt of definitive treatment, whereas HNCSM was modeled using Fine and Gray competing risks. Sensitivity logistic regression analysis was used to determine whether observed interactions remained significant by insurance type (privately insured, Medicaid, and uninsured). Patients without medical insurance were more likely to present with metastatic cancer (adjusted odds ratio, 1.60; P < .001), were more likely to not receive definitive treatment (adjusted odds ratio, 1.64; P < .001), and had a higher risk of HNCSM (adjusted hazard ratio, 1.20; P = .002). Sensitivity analyses showed that when results were stratified by insurance type, significant interactions remained for uninsured patients and patients with Medicaid. Uninsured patients and patients with Medicaid are more likely to present with metastatic disease, are more likely to not be treated definitively, and are at a higher risk of HNCSM. The treatment gap between Medicaid and private insurance observed in this study should serve as an immediate policy target for health care reform. Copyright © 2016 The American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Rule-Based Flight Software Cost Estimation

NASA Technical Reports Server (NTRS)

Stukes, Sherry A.; Spagnuolo, John N. Jr.

2015-01-01

This paper discusses the fundamental process for the computation of Flight Software (FSW) cost estimates. This process has been incorporated in a rule-based expert system [1] that can be used for Independent Cost Estimates (ICEs), Proposals, and for the validation of Cost Analysis Data Requirements (CADRe) submissions. A high-level directed graph (referred to here as a decision graph) illustrates the steps taken in the production of these estimated costs and serves as a basis of design for the expert system described in this paper. Detailed discussions are subsequently given elaborating upon the methodology, tools, charts, and caveats related to the various nodes of the graph. We present general principles for the estimation of FSW using SEER-SEM as an illustration of these principles when appropriate. Since Source Lines of Code (SLOC) is a major cost driver, a discussion of various SLOC data sources for the preparation of the estimates is given together with an explanation of how contractor SLOC estimates compare with the SLOC estimates used by JPL. Obtaining consistency in code counting will be presented as well as factors used in reconciling SLOC estimates from different code counters. When sufficient data is obtained, a mapping into the JPL Work Breakdown Structure (WBS) from the SEER-SEM output is illustrated. For across the board FSW estimates, as was done for the NASA Discovery Mission proposal estimates performed at JPL, a comparative high-level summary sheet for all missions with the SLOC, data description, brief mission description and the most relevant SEER-SEM parameter values is given to illustrate an encapsulation of the used and calculated data involved in the estimates. The rule-based expert system described provides the user with inputs useful or sufficient to run generic cost estimation programs. This system's incarnation is achieved via the C Language Integrated Production System (CLIPS) and will be addressed at the end of this paper.

Incidence of breast carcinoma in women with thyroid carcinoma.

PubMed

Vassilopoulou-Sellin, R; Palmer, L; Taylor, S; Cooksley, C S

1999-02-01

Breast carcinoma and differentiated thyroid carcinoma(the most common endocrine malignancy) occur predominantly in women. An association between the two tumors has been suggested by some investigators, but the potential impact of treatment of one of these diseases on the development of the other remains unclear. The authors examined the relation between the occurrence of these two tumors. There were 41,686 patients with breast carcinoma and 3662 with thyroid carcinoma who registered at The University of Texas M. D. Anderson Cancer Center between March 1944 and April 1997. Women who received both diagnoses since 1976 were identified and incidence rates and relative risks of secondary tumor development were calculated. Surveillance, Epidemiology and End Results (SEER) program data on the age-adjusted incidences of these diseases during the same time period were used for the expected incidences in the same population. Among 18,931 women with a diagnosis of breast carcinoma since 1976, 11 developed differentiated thyroid carcinoma > or = 2 years after the diagnosis of breast carcinoma. These breast carcinoma patients contributed 129,336 person-years of follow-up; the observed incidence of thyroid carcinoma in this group was not different from that in a similar age group of women in the SEER database. Among 1013 women with a diagnosis of thyroid carcinoma since 1976, 24 developed breast carcinoma > or = 2 years after the diagnosis of thyroid carcinoma. These thyroid carcinoma patients contributed 8380 person-years of follow-up; the observed incidence of breast carcinoma in women ages 40-49 years was significantly higher than the expected incidence for women in the same age group in the SEER database. Breast carcinoma developing after thyroid carcinoma was diagnosed more frequently than expected in young adult women seen at the study institution since 1976. This potential association and plausible mechanisms of breast carcinoma development after thyroid carcinoma should be evaluated in larger cohorts of patients.

Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis.

PubMed

Oweira, Hani; Petrausch, Ulf; Helbling, Daniel; Schmidt, Jan; Mannhart, Meinrad; Mehrabi, Arianeb; Schöb, Othmar; Giryes, Anwar; Decker, Michael; Abdel-Rahman, Omar

2017-03-14

To evaluate the prognostic value of site-specific metastases among patients with metastatic pancreatic carcinoma registered within the Surveillance, Epidemiology and End Results (SEER) database. SEER database (2010-2013) has been queried through SEER*Stat program to determine the presentation, treatment outcomes and prognostic outcomes of metastatic pancreatic adenocarcinoma according to the site of metastasis. In this study, metastatic pancreatic adenocarcinoma patients were classified according to the site of metastases (liver, lung, bone, brain and distant lymph nodes). We utilized chi-square test to compare the clinicopathological characteristics among different sites of metastases. We used Kaplan-Meier analysis and log-rank testing for survival comparisons. We employed Cox proportional model to perform multivariate analyses of the patient population; and accordingly hazard ratios with corresponding 95%CI were generated. Statistical significance was considered if a two-tailed P value < 0.05 was achieved. A total of 13233 patients with stage IV pancreatic cancer and known sites of distant metastases were identified in the period from 2010-2013 and they were included into the current analysis. Patients with isolated distant nodal involvement or lung metastases have better overall and pancreatic cancer-specific survival compared to patients with isolated liver metastases (for overall survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001) (for pancreatic cancer-specific survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001). Multivariate analysis revealed that age < 65 years, white race, being married, female gender; surgery to the primary tumor and surgery to the metastatic disease were associated with better overall survival and pancreatic cancer-specific survival. Pancreatic adenocarcinoma patients with isolated liver metastases have worse outcomes compared to patients with isolated lung or distant nodal metastases. Further research is needed to identify the highly selected subset of patients who may benefit from local treatment of the primary tumor and/or metastatic disease.

Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database.

PubMed

Welzel, Tania M; Graubard, Barry I; Zeuzem, Stefan; El-Serag, Hashem B; Davila, Jessica A; McGlynn, Katherine A

2011-08-01

Incidence rates of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) have increased in the United States. Metabolic syndrome is recognized as a risk factor for HCC and a postulated one for ICC. The magnitude of risk, however, has not been investigated on a population level in the United States. We therefore examined the association between metabolic syndrome and the development of these cancers. All persons diagnosed with HCC and ICC between 1993 and 2005 were identified in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database. For comparison, a 5% sample of individuals residing in the same regions as the SEER registries of the cases was selected. The prevalence of metabolic syndrome as defined by the U.S. National Cholesterol Education Program Adult Treatment Panel III criteria, and other risk factors for HCC (hepatitis B virus, hepatitis C virus, alcoholic liver disease, liver cirrhosis, biliary cirrhosis, hemochromatosis, Wilson's disease) and ICC (biliary cirrhosis, cholangitis, cholelithiasis, choledochal cysts, hepatitis B virus, hepatitis C virus, alcoholic liver disease, cirrhosis, inflammatory bowel disease) were compared among persons who developed cancer and those who did not. Logistic regression was used to calculate odds ratios and 95% confidence intervals. The inclusion criteria were met by 3649 HCC cases, 743 ICC cases, and 195,953 comparison persons. Metabolic syndrome was significantly more common among persons who developed HCC (37.1%) and ICC (29.7%) than the comparison group (17.1%, P<0.0001). In adjusted multiple logistic regression analyses, metabolic syndrome remained significantly associated with increased risk of HCC (odds ratio=2.13; 95% confidence interval=1.96-2.31, P<0.0001) and ICC (odds ratio=1.56; 95% confidence interval=1.32-1.83, P<0.0001). Metabolic syndrome is a significant risk factor for development of HCC and ICC in the general U.S. population. Copyright © 2011 American Association for the Study of Liver Diseases.

IDA and the Technical Cooperation Program Real-Time Systems and Ada Workshop, 21-23 June 1988

DTIC Science & Technology

1988-06-01

IDA Memorandum Report M-540, IDA and the Technical Cooperation Program Real - Time Systems and Ada Workshop, 21-23 June 1988, documents the results of... time systems , (2) identify and clarify known Ada real-time issues, (3) identify near-term and long-term solutions, and (4) provide assessment and...Technology (ODUSD R&AT). Funding was provided by the STARS Joint Program Office. The objectives were to (1) define requirements for using Ada in real

Target 88, Shaping the Future. Development Report for 1986-1987. Development Plans for 1987-1988. Annual Development Conference Proceedings (Pittsburg, Kansas, August 19, 1987).

ERIC Educational Resources Information Center

Pittsburg State Univ., KS.

Proceedings of the 1987 Development Conference of Pittsburg State University, Kansas, are presented. The conference reported on the private support program for fiscal year (FY) 1986-1987 and evaluated national development trends and comparisons with peer institutions. Goals of the private support program for 1987-1988 were also reviewed. Contents…

Evaluating the Effectiveness of the 2000-2001 NASA CONNECT(TM) Program

NASA Technical Reports Server (NTRS)

Pinelli, Thomas E.; Frank, Kari Lou; Lambert, Matthew A.

2002-01-01

This report contains the results of the evaluation conducted for the 2000-2001 NASA CONNECT(TM) program conducted in March 2001. The analysis is based on the results collected from 154 surveys collected from educators registered for the program. Respondents indicated that the objectives for each program were met; the programs were aligned with the national (mathematics, science, and technology) standards; the programs were developmentally (grade level) appropriate; and the programs in the 2000-2001 NASA CONNECT(TM) series enhanced/enriched the teaching of mathematics, science, and technology.

Projection of incidence rates to a larger population using ecologic variables.

PubMed

Frey, C M; Feuer, E J; Timmel, M J

1994-09-15

There is wide acceptance of direct standardization of vital rates to adjust for differing age distributions according to the representation within age categories of some referent population. One can use a similar process to standardize, and subsequently project vital rates with respect to continuous, or ratio scale ecologic variables. We obtained from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) programme, a 10 per cent subset of the total U.S. population, country-level breast cancer incidence during 1987-1989 for white women aged 50 and over. We applied regression coefficients that relate ecologic factors to SEER incidence to the full national complement of county-level information to produce an age and ecologic factor adjusted rate that may be more representative of the U.S. than the simple age-adjusted SEER incidence. We conducted a validation study using breast cancer mortality data available for the entire U.S. and which supports the appropriateness of this method for projecting rates.

Water-resources activities in Utah by the U.S. Geological Survey, July 1, 1987 to September 30, 1988

USGS Publications Warehouse

Dragos, Stefanie L.; Gates, Joseph S.

1989-01-01

This report contains summaries of the progress of water-resources studies in Utah by the U.S. Geological Survey, Water Resources Division, Utah District, from July 1, 1987, to September 30, 1988. The program in Utah during this period consisted of 29 projects; a discussion of each project is given in the main body of the report. Short descriptions are given at the end of the report for three projects proposed to be started on or after October 1, 1988. The following sections outline the basic mission and program of the Water Resources Division, the organizational structure of the Utah District, the distribution of District funding in terms of source of funds and type of activity funded, and the agencies with which the District cooperates. The last part of the introduction is a list of reports produced by the District from July 1987 to September 1988.

Establishment of alien registration requirements, 7 January 1988.

PubMed

1988-01-01

On 7 January 1988, the Immigration Commissioner of the Philippines announced that all temporary or permanent aliens resident in the Philippines were required to register with the Commission on Immigration and Deportation in order to legalize their stay in the country. Those who failed to register by a March deadline were subject to immediate deportation. The Commission also set a P500,000 reward for those giving information on the whereabouts of overstaying or undesirable aliens. Effective 21 November 1988, President Corazon Aquino ordered the alien legalization program to be suspended. See Manila Radio Veritas, 18 November 1988; Foreign Broadcast Information Service, FBIS-EAS-88-224, 21 November 1988, p. 41. full text

The Effects of Visual Degradation on Attended Objects and the Ability to Process Unattended Objects within the Visual Array

DTIC Science & Technology

2010-09-01

field at once (e.g., Biederman , Blickle, Teitelbaum, & Klatsky, 1988), and objects of interest typically receive the attention required to recognize them...field ( Biederman & Cooper, 1991) and image size changes ( Biederman & Cooper, 1992). Yet, only attended objects are recognized when mirror images...left-right reversals) occur ( Biederman & Cooper, 1991). Due to these results, Hummel (2001) proposed that attended images are processed by both

Availability of Healthcare Resources and Colorectal Cancer Outcomes Among Non-Hispanic White and Non-Hispanic Black Adults.

PubMed

Akinyemiju, Tomi; Waterbor, John W; Pisu, Maria; Moore, Justin Xavier; Altekruse, Sean F

2016-04-01

This study aims to examine if access to healthcare, measured through the availability of medical resources at the neighborhood level, influences colorectal cancer (CRC) stage, treatment and survival using the Surveillance Epidemiology and Ends Result (SEER) dataset (November 2012), linked with the 2004 Area Resource File. A cross-sectional study was conducted to determine the association between availability of healthcare resources and CRC outcomes among non-Hispanic Black (n = 9162) and non-Hispanic White patients (n = 97,264). CRC patients were identified using the SEER*Stat program, and individual socio-demographic, clinical, and county-level healthcare access variables were obtained for each patient. Among NH-W patients, residence in counties with lower number of oncology hospitals was associated with increased odds of late stage diagnosis (OR 1.09, 95 % CI 1.04-1.14), reduced odds of receiving surgery (OR 0.83, 95 % CI 0.74-0.92) and higher hazard rates (HR 1.09, 95 % CI 1.06-1.12). There were no significant associations among NH-B patients. Increased availability of healthcare resources improves CRC outcomes among NH-W patients. However, future studies are required to better understand healthcare utilization patterns in NH-B neighborhoods, and identify other important dimensions of healthcare access such as affordability, acceptability and accommodation.

Radiotherapy improves survival in unresected stage I-III bronchoalveolar carcinoma.

PubMed

Urban, Damien; Mishra, Mark; Onn, Amir; Dicker, Adam P; Symon, Zvi; Pfeffer, M Raphael; Lawrence, Yaacov Richard

2012-11-01

To test the hypothesis that radiotherapy (RT) improves the outcome of patients with unresected, nonmetastatic bronchoalveolar carcinoma (BAC) by performing a population-based analysis within the Surveillance, Epidemiology, and End Results (SEER) registry. Inclusion criteria were as follows: patients diagnosed with BAC, Stage I-III, between 2001 and 2007. Exclusion criteria included unknown stage, unknown primary treatment modality, Stage IV disease, and those diagnosed at autopsy. Demographic data, treatment details, and overall survival were retrieved from the SEER database. Survival was analyzed using the Kaplan-Meier method and log-rank test. A total of 6933 patients with Stage I-III BAC were included in the analysis. The median age at diagnosis was 70 years (range, 10-101 years). The majority of patients were diagnosed with Stage I (74.4%); 968 patients (14%) did not undergo surgical resection. Unresected patients were more likely to be older (p < 0.0001), male (p = 0.001), black (p < 0.0001), and Stage III (p < 0.0001). Within the cohort of unresected patients, 300 (31%) were treated with RT. The estimated 2-year overall survival for patients with unresected, nonmetastatic BAC was 58%, 44%, and 27% in Stage I, II, and III, respectively. Factors associated with improved survival included female sex, earlier stage at diagnosis, and use of RT. Median survival in those not receiving RT vs. receiving RT was as follows: Stage I, 28 months vs. 33 months (n = 364, p = 0.06); Stage II, 18 months vs. not reached (n = 31, nonsignificant); Stage III, 10 months vs. 17 months (n = 517, p < 0.003). The use of RT is associated with improved prognosis in unresected Stage I-III BAC. Less than a third of patients who could have potentially benefited from RT received it, suggesting that the medical specialists involved in the care of these patients underappreciate the importance of RT. Copyright © 2012 Elsevier Inc. All rights reserved.

Radiotherapy Improves Survival in Unresected Stage I-III Bronchoalveolar Carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Urban, Damien; Mishra, Mark; Onn, Amir

2012-11-01

Purpose: To test the hypothesis that radiotherapy (RT) improves the outcome of patients with unresected, nonmetastatic bronchoalveolar carcinoma (BAC) by performing a population-based analysis within the Surveillance, Epidemiology, and End Results (SEER) registry. Methods and Materials: Inclusion criteria were as follows: patients diagnosed with BAC, Stage I-III, between 2001 and 2007. Exclusion criteria included unknown stage, unknown primary treatment modality, Stage IV disease, and those diagnosed at autopsy. Demographic data, treatment details, and overall survival were retrieved from the SEER database. Survival was analyzed using the Kaplan-Meier method and log-rank test. Results: A total of 6933 patients with Stage I-IIImore » BAC were included in the analysis. The median age at diagnosis was 70 years (range, 10-101 years). The majority of patients were diagnosed with Stage I (74.4%); 968 patients (14%) did not undergo surgical resection. Unresected patients were more likely to be older (p < 0.0001), male (p = 0.001), black (p < 0.0001), and Stage III (p < 0.0001). Within the cohort of unresected patients, 300 (31%) were treated with RT. The estimated 2-year overall survival for patients with unresected, nonmetastatic BAC was 58%, 44%, and 27% in Stage I, II, and III, respectively. Factors associated with improved survival included female sex, earlier stage at diagnosis, and use of RT. Median survival in those not receiving RT vs. receiving RT was as follows: Stage I, 28 months vs. 33 months (n = 364, p = 0.06); Stage II, 18 months vs. not reached (n = 31, nonsignificant); Stage III, 10 months vs. 17 months (n = 517, p < 0.003). Conclusions: The use of RT is associated with improved prognosis in unresected Stage I-III BAC. Less than a third of patients who could have potentially benefited from RT received it, suggesting that the medical specialists involved in the care of these patients underappreciate the importance of RT.« less

Chromophobe Renal Cell Carcinoma is the Most Common Nonclear Renal Cell Carcinoma in Young Women: Results from the SEER Database.

PubMed

Daugherty, Michael; Blakely, Stephen; Shapiro, Oleg; Vourganti, Srinivas; Mollapour, Mehdi; Bratslavsky, Gennady

2016-04-01

The renal cell cancer incidence is relatively low in younger patients, encompassing 3% to 7% of all renal cell cancers. While young patients may have renal tumors due to hereditary syndromes, in some of them sporadic renal cancers develop without any family history or known genetic mutations. Our recent observations from clinical practice have led us to hypothesize that there is a difference in histological distribution in younger patients compared to the older cohort. We queried the SEER (Surveillance, Epidemiology and End Results) 18-registry database for all patients 20 years old or older who were surgically treated for renal cell carcinoma between 2001 and 2008. Patients with unknown race, grade, stage or histology and those with multiple tumors were excluded from study. Four cohorts were created by dividing patients by gender, including 1,202 females and 1,715 males younger than 40 years old, and 18,353 females and 30,891 males 40 years old or older. Chi-square analysis was used to compare histological distributions between the cohorts. While clear cell carcinoma was still the most common renal cell cancer subtype across all genders and ages, chromophobe renal cell cancer was the most predominant type of nonclear renal cell cancer histology in young females, representing 62.3% of all nonclear cell renal cell cancers (p <0.0001). In all other groups papillary renal cell cancer remained the most common type of nonclear renal cell cancer. It is possible that hormonal factors or specific pathway dysregulations predispose chromophobe renal cell cancer to develop in younger women. We hope that this work provides some new observations that could lead to further studies of gender and histology specific renal tumorigenesis. Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

A statewide investigation of geographic lung cancer incidence patterns and radon exposure in a low-smoking population.

PubMed

Ou, Judy Y; Fowler, Brynn; Ding, Qian; Kirchhoff, Anne C; Pappas, Lisa; Boucher, Kenneth; Akerley, Wallace; Wu, Yelena; Kaphingst, Kimberly; Harding, Garrett; Kepka, Deanna

2018-01-31

Lung cancer is the leading cause of cancer-related mortality in Utah despite having the nation's lowest smoking rate. Radon exposure and differences in lung cancer incidence between nonmetropolitan and metropolitan areas may explain this phenomenon. We compared smoking-adjusted lung cancer incidence rates between nonmetropolitan and metropolitan counties by predicted indoor radon level, sex, and cancer stage. We also compared lung cancer incidence by county classification between Utah and all SEER sites. SEER*Stat provided annual age-adjusted rates per 100,000 from 1991 to 2010 for each Utah county and all other SEER sites. County classification, stage, and sex were obtained from SEER*Stat. Smoking was obtained from Environmental Public Health Tracking estimates by Ortega et al. EPA provided low (< 2 pCi/L), moderate (2-4 pCi/L), and high (> 4 pCi/L) indoor radon levels for each county. Poisson models calculated overall, cancer stage, and sex-specific rates and p-values for smoking-adjusted and unadjusted models. LOESS smoothed trend lines compared incidence rates between Utah and all SEER sites by county classification. All metropolitan counties had moderate radon levels; 12 (63%) of the 19 nonmetropolitan counties had moderate predicted radon levels and 7 (37%) had high predicted radon levels. Lung cancer incidence rates were higher in nonmetropolitan counties than metropolitan counties (34.8 vs 29.7 per 100,000, respectively). Incidence of distant stage cancers was significantly higher in nonmetropolitan counties after controlling for smoking (16.7 vs 15.4, p = 0.02*). Incidence rates in metropolitan, moderate radon and nonmetropolitan, moderate radon counties were similar. Nonmetropolitan, high radon counties had a significantly higher incidence of lung cancer compared to nonmetropolitan, moderate radon counties after adjustment for smoking (41.7 vs 29.2, p < 0.0001*). Lung cancer incidence patterns in Utah were opposite of metropolitan/nonmetropolitan trends in other SEER sites. Lung cancer incidence and distant stage incidence rates were consistently higher in nonmetropolitan Utah counties than metropolitan counties, suggesting that limited access to preventative screenings may play a role in this disparity. Smoking-adjusted incidence rates in nonmetropolitan, high radon counties were significantly higher than moderate radon counties, suggesting that radon was also major contributor to lung cancer in these regions. National studies should account for geographic and environmental factors when examining nonmetropolitan/metropolitan differences in lung cancer.

State of Washington Aquatic Plant Management Program. Supplement

DTIC Science & Technology

1991-03-01

which are sticky fluids such as inverting oils and polymers, or fibers, which enhance clinging to submersed vegetation (Getsinger and Westerdahl , 1988...primarily by photolysis, by biodegradation, and least significantly by volatilization ( Westerdahl and Getsinger 1988). Thus, there is no reason for... Westerdahl . 1988. Hiscellaneous-Paper A-88-1, Waterways Experimental Station, COE, Vicksburg, MS, 24 pp. Gibbons, M.V., H.L. Gibbons, and R. Pine:. 1987. 1986

Clinical Investigation Program RCS-MED-300 (R1)

DTIC Science & Technology

1988-09-30

34, pluse one letter to the editor, and one article published (1986 and 1987). . .. ..... .......... .. . • m mmm il lm9 DETAIL SUMMARY SHEET DATE: 1 ...SUMMARY SHEET DATE: 1 October 1988 PROTOCOL #: 87/08 STATUS: Completed TITLE: A Pilot Study on Effect of Nicotine and Cigarette Smoking on...Clinical Immunology, Anaheim, California in March 1988. 29 DETAIL SUMMARY SHEET DATE: 1 October 1988 PROTOCOL #: 87/12 STATUS: Terminated TITLE: Effect

Anchorage School District Full-Day Kindergarten Study: A Follow-up of the Kindergarten Classes of 1987-88, 1988-89, and 1989-90.

ERIC Educational Resources Information Center

Stofflet, Frederick P.

This study examined Anchorage School District (Alaska) kindergarten classes from 1987-88, 1988-89, and 1989-90; these years correspond to the last year in which there was no full-day kindergarten program in the district, and the first and second years of the district's full-day program. The study examined matriculation patterns, special education…

Program Manager: Journal of the Defense Systems Management College. Volume 17, Number 4, July-August 1988

DTIC Science & Technology

1988-08-01

occurrences. Management Collge . Program Manager 22 Julv-August 1988 .K % € 4...playing parts in developingProductivity Measurement. 2 Selec- Q4: Out-going quality control the guide hope it will do the tion of physical , temporal...Management Collge byThe Honorable Bill Nichols, Democratk • The Congress emphasized educa- o ngressmanfrom Alabama, to the Army -neatly and give the

Renal cell cancer in Israel: sex and ethnic differences in incidence and mortality, 1980-2004.

PubMed

Tarabeia, Jalal; Kaluski, Dorit Nitzan; Barchana, Micha; Dichtiar, Rita; Green, Manfred S

2010-06-01

The causes of renal cell cancer (RCC) remain largely unexplained. While the incidence is generally higher in men than in women, little has been reported on ethnic differences. We examine trends in RCC incidence and mortality rates among Israeli Arab and Jewish populations and compared with the rates in other countries. Age-adjusted RCC incidence and mortality rates in Israel, during 1980-2004, were calculated by sex and population group, using the National Cancer Registry. They were compared with the United States based on the Surveillance Epidemiology and End Results [SEER] program and the IARC database for international comparisons. While RCC incidence rates in Israel are similar to the United States and the European average, the rates are significantly higher among Israeli Jews than Arabs. Men are affected more than women. Incidence rates over the last 24 years have increased among all men and Jewish women, but not among Arab women. Among men, the incidence rate ratio for Jews to Arabs declined from 3.96 in 1980-1982 to 2.34 in 2001-2004, whereas for women there was no change. The mortality rates were higher among Jews than Arab and among men than women. There were no significant change in the mortality rates and rate ratios. Our findings demonstrate marked ethnic differences in RCC in Israel. The lower incidence among Arabs stands in contrast to the higher prevalence of potential risk factors for RCC in this population group. Genetic factors, diet and other lifestyle factors could play protective roles. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Publications of the Exobiology Program for 1988: A special bibliography

NASA Technical Reports Server (NTRS)

1990-01-01

The 1988 publications resulting from research pursued under the auspices of NASA's Exobiology Program are listed. The Exobiology Program is an integrated program designed to investigate those processes that may have been responsible for or related to the origin, evolution, and distribution of life in the universe. Research supported by this program is in the areas of cosmic evolution of biogenic compounds, prebiotic evolution, early evolution of life, and evolution of advanced life. Pre-mission and pre-project activities supporting these areas are included in the areas of solar system exploration and the search for extraterrestrial intelligence. A planetary protection subject area is also included because of its direct relevance to the Exobiology program.

Anti-tobacco television advertising and indicators of smoking cessation in adults: a cohort study.

PubMed

Hyland, A; Wakefield, M; Higbee, Cheryl; Szczypka, G; Cummings, K M

2006-04-01

The objective of this study was to assess the relationship between exposure to state-sponsored anti-tobacco advertising and smoking cessation. Cessation rates in 2001 among a cohort of 2061 smokers who participated in the Community Intervention Trial for Smoking Cessation between 1988 and 1993 and completed a follow-up survey in 2001 were merged with the 2000-01 television advertising exposure data from Nielsen Media Research. The relative risk for quitting was estimated to be 10% higher for every 5000 units of exposure to state anti-tobacco television advertising over the 2-year period, although this did not quite achieve statistical significance. The association was even larger among those who reported that the level of information in the media about the dangers of smoking had increased 'a lot' between 1993 and 2001 (RR = 1.19, 95% CI = 1.03-1.38). These data are consistent with the finding that increased exposure to state anti-tobacco media increases smoking cessation rates.

Anti-tobacco television advertising and indicators of smoking cessation in adults: a cohort study.

PubMed

Hyland, A; Wakefield, M; Higbee, Cheryl; Szczypka, G; Cummings, K M

2006-06-01

The objective of this study was to assess the relationship between exposure to state-sponsored anti-tobacco advertising and smoking cessation. Cessation rates in 2001 among a cohort of 2061 smokers who participated in the Community Intervention Trial for Smoking Cessation between 1988 and 1993 and completed a follow-up survey in 2001 were merged with 2000-01 television advertising exposure data from Nielsen Media Research. The relative risk for quitting was estimated to be 10% higher for every 5000 units of exposure to state anti-tobacco television advertising over the 2-year period, although this did not quite achieve statistical significance. The association was even larger among those who reported that the level of information in the media about the dangers of smoking had increased 'a lot' between 1993 and 2001 (RR = 1.19, 95% CI = 1.03-1.38). These data are consistent with the finding that increased exposure to state anti-tobacco media increases smoking cessation rates.

Sherman Creek Hatchery; Washington Department of Fish and Wildlife Fish Program, 2001 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Combs, Mitch

2002-01-01

Sherman Creek Hatchery's primary objective is the restoration and enhancement of the recreational and subsistence fishery in Lake Roosevelt and Banks Lake. The Sherman Creek Hatchery (SCH) was designed to rear 1.7 million kokanee fry for acclimation and imprinting during the spring and early summer. Additionally, it was designed to trap all available returning adult kokanee during the fall for broodstock operations and evaluations. Since the start of this program, the operations on Lake Roosevelt have been modified to better achieve program goals. The Washington Department of Fish and Wildlife, Spokane Tribe of Indians and the Colville Confederated Tribe formmore » the interagency Lake Roosevelt Hatcheries Coordination Team (LRHCT) which sets goals and objectives for both Sherman Creek and the Spokane Tribal Hatchery and serves to coordinate enhancement efforts on Lake Roosevelt and Banks Lake. The primary changes have been to replace the kokanee fingerling program with a yearling (post smolt) program of up to 1,000,000 fish. To construct and operate twenty net pens to handle the increased production. The second significant change was to rear up to 300,000 rainbow trout fingerling at SCH from July through October, for stocking into the volunteer net pens. This enables the Spokane Tribal Hatchery (STH) to rear additional kokanee to further the enhancement efforts on Lake Roosevelt. Current objectives include increased use of native/indigenous stocks where available for propagation into Upper Columbia River Basin Waters. Monitoring and evaluation is preformed by the Lake Roosevelt Fisheries Monitoring Program. From 1988 to 1998, the principle sport fishery on Lake Roosevelt has shifted from walleye to include rainbow trout and kokanee salmon (Underwood et al. 1997, Tilson and Scholz 1997). The angler use, harvest rates for rainbow and kokanee and the economic value of the fishery has increased substantially during this 10-year period. The most recent information from the monitoring program also suggests that the hatchery and net pen rearing programs have been beneficial to enhancing the Lake Roosevelt fishery while not negatively impacting wild and native stocks within the lake. The 2001 fishing season has been especially successful with great fishing for both rainbow and kokanee throughout Lake Roosevelt. The results of the Two Rivers Fishing Derby identified 100 percent of the rainbow and 47 percent of the kokanee caught were of hatchery origin.« less

Survey of United States Army Reserve (USAR) Troop Program Unit (TPU) soldiers 1989. Tabulation of Questionnaire Responses: Longitudinal Sample: Junior Enlisted Stayers from 1988 to 1989. 1989 Questionnaire Responses

DTIC Science & Technology

1989-09-30

AD-A237 531 1989 SURVEY OF UNITED STATES ARMY RESERVE (USAR) TROOP PROGRAM UNIT (TPU) SOLDIERS Tabulation of Questionnaire Responses: Longitudinal...Program Unit (TPU) Soldiers . The Tabulation Volumes list questionnaire items and the percent of respondents (weighted to population estimates) who have...Reserve population eligible for selection was defined by the number of personnel rec,,rds on a Dpeber 1988 SIDPERS data base; this totalled 280,265

Military Construction and Family Housing Program. Fiscal Year (FY) 2001 Budget Estimates

DTIC Science & Technology

2000-02-01

Department of the Air Force Military Construction and Family Housing Program Fiscal Year (FY) 2001 Budget Estimates Justification Data...Department of the Air Force Military Construction and Military Family Housing Program Summary Fiscal Year 2001 Appropriation Authorization Request... FISCAL YEAR 2001 (DOLLARS IN THOUSANDS) STATE/COUNTRY INSTALLATION TITLE APPROP REQUEST AUTH REQUEST PAGE INSIDE THE U.S. ALABAMA

Amended FY 1988/1989 Biennial Budget Justification of Estimates Submitted to Congress

DTIC Science & Technology

1988-02-01

will be installed in order to provide privacy for network data traffic. - Distributed systems technology will continue to be explored, including...techniques and geophysical and satellite data bases to make relevant information rapidly available to the ".fi /./ P ... . C / AMENDED FY 1988/1989...semantic model of available functions and data , %. AMENDED FV 1988/1989 BIENNIAL BUDGET RDT&E DESCRIPTIVE SUMMARY Program Element: fQ1Q0j, Title

Defense and Arms Control Studies Program, Annual Report, 1988-1989

DTIC Science & Technology

1989-09-01

meetings of the U.S. and British History of Science Societies, Manchester, England, July 1988. Sapolsky, Harvey, "The Future of Technology Policy Studies... of Science Societies, Manchester, England "Politics of Weapon Acquisition Corruption," Political Science Seminar, Washington University, St. Louis...December 1988 March 1989 April 1989 "Military Support for Academic Research in the United States," paper at the joint meetings of U.S. and British History

Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Adah S.; Ostrom, Quinn T.; Kruchko, Carol

Complete prevalence proportions illustrate the burden of disease in a population. Here, this study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0–14 y), adolescent and young adult (AYA) (15–39 y), and adult (40+ y).

Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010

DOE PAGES

Zhang, Adah S.; Ostrom, Quinn T.; Kruchko, Carol; ...

2016-12-29

Complete prevalence proportions illustrate the burden of disease in a population. Here, this study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0–14 y), adolescent and young adult (AYA) (15–39 y), and adult (40+ y).

Spatial and temporal multiyear sea ice distributions in the Arctic: A neural network analysis of SSM/I data, 1988-2001

USGS Publications Warehouse

Belchansky, G.I.; Douglas, David C.; Alpatsky, I.V.; Platonov, Nikita G.

2004-01-01

Arctic multiyear sea ice concentration maps for January 1988-2001 were generated from SSM/I brightness temperatures (19H, 19V, and 37V) using modified multiple layer perceptron neural networks. Learning data for the neural networks were extracted from ice maps derived from Okean and ERS satellite imagery to capitalize on the stability of active radar multiyear ice signatures. Evaluations of three learning algorithms and several topologies indicated that networks constructed with error back propagation learning and 3-20-1 topology produced the most consistent and physically plausible results. Operational neural networks were developed specifically with January learning data, and then used to estimate daily multiyear ice concentrations from daily-averaged SSM/I brightness temperatures during January. Monthly mean maps were produced for analysis by averaging the respective daily estimates. The 14-year series of January multiyear ice distributions revealed dense and persistent cover in the central Arctic surrounded by expansive regions of highly fluctuating interannual cover. Estimates of total multiyear ice area by the neural network were intermediate to those of other passive microwave algorithms, but annual fluctuations and trends were similar among all algorithms. When compared to Radarsat estimates of multiyear ice concentration in the Beaufort and Chukchi Seas (1997-1999), average discrepancies were small (0.9-2.5%) and spatial coherency was reasonable, indicating the neural network's Okean and ERS learning data facilitated passive microwave inversion that emulated backscatter signatures. During 1988-2001, total January multiyear ice area declined at a significant linear rate of -54.3 x 103 km2/yr-1 (-1.4%/yr-1). The most persistent and extensive decline in multiyear ice concentration (-3.3%/yr-1) occurred in the southern Beaufort and Chukchi Seas. In autumn 1996, a large multiyear ice recruitment of over 106 km2 (mostly in the Siberian Arctic) fully replenished the previous 8-year decline in total area, but it was followed by an accelerated and compensatory decline during the subsequent 4 years. Seventy-five percent of the interannual variation in January multiyear sea ice area was explained by linear regression on two atmospheric parameters: the previous inter's (JFM) Arctic Oscillation index as a proxy to melt duration and the previous year's average sea level pressure gradient across the Fram Strait as a proxy to annual ice export. Consecutive year changes (1994-2001) in January multiyear ice volume were significantly correlated with duration of the intervening melt season (R2 = 0.73, -80.0 km3/d-1), emphasizing a large thermodynamic influence on the Arctic's mass sea ice balance during summers with anomalous melt durations.

Perceptions of Regime Legitimacy in Mozambique: Legitimacy in Transition?

DTIC Science & Technology

2006-09-01

West Africa Since Independence (Lagos: Lagos University Press, 1988) 170 . 52 James S. Wunsch and Dan Ottemoeller in Dele Olowu and James S. Wunsch...Ultramarina (RAU), aprovada pelo Decreto –Lei n. ˚23229, de 15 de Novembro de 1933. “Em cada uma das regedorias, a autoridade sobre as populações...2001. Artigo 94 da Reforma Adminsitrativa Ultramarina (RAU), aprovada pelo Decreto –Lei n. ˚23229, de 15 de Novembro de 1933. Ayittey, George B

National Aviation Security Policy, Strategy, and Mode-Specific Plans: Background and Considerations for Congress

DTIC Science & Technology

2009-02-02

aviation security . The approach to aviation security was largely shaped by past events, such as the bombing of Pan Am flight 103 in December 1988, rather...community. Following the September 11, 2001, attacks, U.S. aviation security policy and strategy was closely linked to the changes called for in the...have been considered security sensitive thus limiting public discourse on the DHS strategy for aviation security . However, in June 2006 President

40 CFR 272.1601 - New Mexico State-Administered Program: Final Authorization.

Code of Federal Regulations, 2010 CFR

2010-07-01

... inspect a copy at EPA Region 6, 1445 Ross Avenue, Dallas, Texas 75202 (Phone number (214) 665-8533), or at... 13, 1988; September 14, 1988; July 19, 1989; July 23, 1992; February 14, 1994; July 18, 1994; July 20...

[Work-related musculoskeletal diseases: experience of INAIL of the Apulia region 1998-2001].

PubMed

Allamprese, P; Attimonelli, R; Gigante, M R; Soleo, L

2005-01-01

The insurance recognition of Work related Muscolo Skeletal Disorders (WMSDs) has been introduced in Italy by the sentences of Constitutional Court n. 179/1988 and 208/1988. Afterwards the National Insurance Institute against work injuries (INAIL) tried to make homogeneous, in the different INAIL regional Departments, the diagnostic protocol of the work related illness associated with repetitive manual activities. Since 1998, indeed, a clinical diagnostic protocol has been used in the different departments. This report describes the Work related Muscolo Skeletal Disorders submitted to the Apulian INAIL Regional Direction in the period 1998-2001. Among 84 cases of disease reported to the Regional Direction, 21 were recognised as professional illness, the most part of which in workers employed in services sector and mining activities. The most represented disease was carpal tunnel syndrome and it was more recurrent in men than in women, in which the first symptoms were earlier than in men. The most represented risk factor, both in reported and in recognised cases, was the presence of repetitive working movements of the upper extremities, or the combination of the previous one with other risk factors such as high frequency of working activities, postural risk, strength demand, vibrations, climatic conditions. The development of specific diagnostic criteria, the detailed job analysis and the use of specific questionnaires seem to be the main elements for the WMSDs diagnosis and for the recognition of their professional etiology.

Temporal and Longitudinal Mercury Trends in Burbot (Lota lota) in the Russian Arctic.

PubMed

Pelletier, Alexander R; Castello, Leandro; Zhulidov, Alexander V; Gurtovaya, Tatiana Yu; Robarts, Richard D; Holmes, Robert M; Zhulidov, Daniel A; Spencer, Robert G M

2017-11-21

Current understanding of mercury (Hg) dynamics in the Arctic is hampered by a lack of data in the Russian Arctic region, which comprises about half of the entire Arctic watershed. This study quantified temporal and longitudinal trends in total mercury (THg) concentrations in burbot (Lota lota) in eight rivers of the Russian Arctic between 1980 and 2001, encompassing an expanse of 118 degrees of longitude. Burbot THg concentrations declined by an average of 2.6% annually across all eight rivers during the study period, decreasing by 39% from 0.171 μg g -1 wet weight (w.w.) in 1980 to 0.104 μg g -1 w.w. in 2001. THg concentrations in burbot also declined by an average of 1.8% per 10° of longitude from west to east across the study area between 1988 and 2001. These results, in combination with those of previous studies, suggest that Hg trends in Arctic freshwater fishes before 2001 were spatially and temporally heterogeneous, as those in the North American Arctic were mostly increasing while those in the Russian Arctic were mostly decreasing. It is suggested that Hg trends in Arctic animals may be influenced by both depositional and postdepositional processes.

Analysis of SEER Adenosquamous Carcinoma Data to Identify Cause Specific Survival Predictors and Socioeconomic Disparities.

PubMed

Cheung, Rex

2016-01-01

This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) adenosquamous carcinoma data to identify predictive models and potential disparities in outcome. This study analyzed socio-economic, staging and treatment factors available in the SEER database for adenosquamous carcinoma. For the risk modeling, each factor was fitted by a generalized linear model to predict the cause specific survival. An area under the receiver operating characteristic curve (ROC) was computed. Similar strata were combined to construct the most parsimonious models. A total of 20,712 patients diagnosed from 1973 to 2009 were included in this study. The mean follow up time (S.D.) was 54.2 (78.4) months. Some 2/3 of the patients were female. The mean (S.D.) age was 63 (13.8) years. SEER stage was the most predictive factor of outcome (ROC area of 0.71). 13.9% of the patients were un-staged and had risk of cause specific death of 61.3% that was higher than the 45.3% risk for the regional disease and lower than the 70.3% for metastatic disease. Sex, site, radiotherapy, and surgery had ROC areas of about 0.55-0.65. Rural residence and race contributed to socioeconomic disparity for treatment outcome. Radiotherapy was underused even with localized and regional stages when the intent was curative. This under use was most pronounced in older patients. Anatomic stage was predictive and useful in treatment selection. Under-staging may have contributed to poor outcome.

Identification of SSEA-1 expressing enhanced reprogramming (SEER) cells in porcine embryonic fibroblasts

PubMed Central

Li, Dong; Secher, Jan O.; Mashayekhi, Kaveh; Nielsen, Troels T.; Hyttel, Poul; Freude, Kristine K.

2017-01-01

ABSTRACT Previous research has shown that a subpopulation of cells within cultured human dermal fibroblasts, termed multilineage-differentiating stress enduring (Muse) cells, are preferentially reprogrammed into induced pluripotent stem cells. However, controversy exists over whether these cells are the only cells capable of being reprogrammed from a heterogeneous population of fibroblasts. Similarly, there is little research to suggest such cells may exist in embryonic tissues or other species. To address if such a cell population exists in pigs, we investigated porcine embryonic fibroblast populations (pEFs) and identified heterogeneous expression of several key cell surface markers. Strikingly, we discovered a small population of stage-specific embryonic antigen 1 positive cells (SSEA-1+) in Danish Landrace and Göttingen minipig pEFs, which were absent in the Yucatan pEFs. Furthermore, reprogramming of SSEA-1+ sorted pEFs led to higher reprogramming efficiency. Subsequent transcriptome profiling of the SSEA-1+ vs. the SSEA-1neg cell fraction revealed highly comparable gene signatures. However several genes that were found to be upregulated in the SSEA-1+ cells were similarly expressed in mesenchymal stem cells (MSCs). We therefore termed these cells SSEA-1 Expressing Enhanced Reprogramming (SEER) cells. Interestingly, SEER cells were more effective at differentiating into osteocytes and chondrocytes in vitro. We conclude that SEER cells are more amenable for reprogramming and that the expression of mesenchymal stem cell genes is advantageous in the reprogramming process. This data provides evidence supporting the elite theory and helps to delineate which cell types and specific genes are important for reprogramming in the pig. PMID:28426281

ELF (Extremely Low Frequency) Communications System - Ecological Monitoring Program: Summary of 1988 Progress

DTIC Science & Technology

1989-11-01

of fresh leaves are fast at both sites. 3 Similar comparisons using autumn abscised leaves show intermediate processing rates at the treatment site...processing fresh or autumn- abscised leaves during 1988 (t-test). Analyses of variance showed that fresh leaves were pricessed significantly faster at the...Northern Journal of Applied Forestry, 5:14, 1988. 22 Connaughton, P. The effects of acid precipi*ation on nutrient levels in a forest soil and foliage of

The Military Construction (MILCON) Program and Privatization: A Comparative Analysis

DTIC Science & Technology

1990-09-01

Government Contract Law , 1988: 13-4). The Davis-Bacon Act is implemented by Federal Acquisition Regulation (FAR) 22.400 and mandates that five provisions be...wages as determined by the Secretary of Labor (Dept. of the AF: Government Contract Law , 1988:13- 4). The Department of Labor wage determinations...Posting 4 - Withholding Payments 5 - Termination for Default 26 (Dept. of the AF: Government Contract Law , 1988: 13-4, 13-5) The residential schedule rates

Influence of morphology on survival for non-Hodgkin lymphoma in Europe and the United States.

PubMed

Sant, Milena; Allemani, Claudia; De Angelis, Roberta; Carbone, Antonino; de Sanjosè, Silvia; Gianni, Alessandro M; Giraldo, Pilar; Marchesi, Francesca; Marcos-Gragera, Rafael; Martos-Jiménez, Carmen; Maynadié, Marc; Raphael, Martine; Berrino, Franco

2008-03-01

We explored the influence of morphology on geographic differences in 5-year survival for non-Hodgkin lymphoma (NHL) diagnosed in 1990-1994 and followed for 5years: 16,955 cases from 27 EUROCARE-3 cancer registries, and 22,713 cases from 9 US SEER registries. Overall 5-year relative survival was 56.1% in EUROCARE west, 47.1% in EUROCARE east and 56.3% in SEER. Relative excess risk (RER) of death was 1.05 (95% confidence interval (CI) 1.01-1.10) in EUROCARE west, 1.52 (95% CI 1.44-1.60) in EUROCARE east (SEER reference). Excess risk of death was significantly above reference (diffuse B lymphoma) for Burkitt's and NOS lymphoma; not different for lymphoblastic and other T-cell; significantly below reference (in the order of decreasing relative excess risk) for NHL NOS, mantle cell/centrocytic, lymphoplasmacytic, follicular, small lymphocytic/chronic lymphocytic leukaemia, other specified NHL and cutaneous morphologies. Interpretation of marked variation in survival with morphology is complicated by classification inconsistencies. The completeness and standardisation of cancer registry morphology data needs to be improved.

Hourly simulation of a Ground-Coupled Heat Pump system

NASA Astrophysics Data System (ADS)

Naldi, C.; Zanchini, E.

2017-01-01

In this paper, we present a MATLAB code for the hourly simulation of a whole Ground-Coupled Heat Pump (GCHP) system, based on the g-functions previously obtained by Zanchini and Lazzari. The code applies both to on-off heat pumps and to inverter-driven ones. It is employed to analyse the effects of the inverter and of the total length of the Borehole Heat Exchanger (BHE) field on the mean seasonal COP (SCOP) and on the mean seasonal EER (SEER) of a GCHP system designed for a residential house with 6 apartments in Bologna, North-Center Italy, with dominant heating loads. A BHE field with 3 in line boreholes is considered, with length of each BHE either 75 m or 105 m. The results show that the increase of the BHE length yields a SCOP enhancement of about 7%, while the SEER remains nearly unchanged. The replacement of the on-off heat pump by an inverter-driven one yields a SCOP enhancement of about 30% and a SEER enhancement of about 50%. The results demonstrate the importance of employing inverter-driven heat pumps for GCHP systems.

Virginia's program to combat drug-related DUI, 1988-1989.

DOT National Transportation Integrated Search

1992-01-01

Beginning on April 1, 1988, a revision to Virginia law gave police officers the authority to require an individual suspected of driving under the influence (DUI) of drugs to submit a blood sample to be tested for drug content. Concurrent with the imp...

NASA geodynamics program: Bibliography

NASA Technical Reports Server (NTRS)

1990-01-01

The Seventh Geodynamics Program report summarizes program activities and achievements during 1988 and 1989. Included is a 115 page bibliography of the publications associated with the NASA Geodynamics Program since its initiation in 1979.

Bio-optical profile data report coastal transition zone program, R/V Thomas Washington, June 24 - July 21, 1988

NASA Technical Reports Server (NTRS)

Davis, Curtiss O.; Rhea, W. Joseph

1990-01-01

Twenty-three vertical profiles of the bio-optical properties of the ocean were made during a research cruise on the R/V Thomas Washington, June 24 to July 21, 1988, as part of the Coastal Transition Zone Program off Point Arena, California. A summary is given, to provide investigators with an overview of the data collected. The entire data set is available in digital form for interested researchers.

Economic Factors Shaping China’s Defense Spending: Historical Trends and Recent Developments

DTIC Science & Technology

2010-09-01

the Technological Transformation of Japan . (Ithaca, NY: Cornell University Press, 1996), 1-32. 2 The question has been treated at a broad...1988-97, which nearly matched increases in state financial expenditure at 15.1 percent, but amid GDP growth of 20.7 percent and significant inflation ...observe that “in September 1988 the central government initiated an austerity program in response to rising inflation ….This program, in conjunction with

H.R. 4904, Technology-Related Assistance for Individuals with Disabilities Act of 1988. Hearing before the Subcommittee on Select Education of the Committee on Education and Labor. House of Representatives, One Hundredth Congress, Second Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Education and Labor.

Testimony is presented on H.R. 4904, "Technology-Related Assistance for Individuals with Disabilities Act of 1988." The legislation allows states to apply for grants to be used to develop and implement a consumer-responsive statewide program of technology-related assistance. States may develop the program by providing assistive…

Experimental Injury Biomechanics of the Pediatric Neck

NASA Astrophysics Data System (ADS)

Nightingale, Roger W.; Luck, Jason F.

Motor vehicle related crashes rank as the most common cause of spinal related injuries in the pediatric population (Platzer et al. 2007; Brown et al. 2001; Kokoska et al. 2001; Eleraky et al. 2000; Hamilton and Myles 1992a; Bonadio 1993; Babcock 1975). Pediatric spinal related trauma accounts for between 1 and 12 % of all spinal related injuries (Hamilton and Myles 1992a; Hadley et al. 1988; Aufdermaur 1974). Cervical spine trauma in children accounts for approximately 2 % of all cervical spinal injuries (Henrys et al. 1977). Approximately 1-2 % of all children admitted for traumatic injury are related to injuries to the cervical spine (Platzer et al. 2007; Brown et al. 2001; Kokoska et al. 2001; Orenstein et al. 1994; Rachesky et al. 1987). Overall, pediatric neck injury rates are significantly lower than adult rates; however, the neck injury rate in children between the ages of 11 and 15 years approaches the adult rate of 18.8 per 100,000 (McGrory et al 1993; Myers and Winkelstein 1995). For children less than 11 years of age, neck injuries are relatively rare (1.2 per 100,000), but have particularly devastating consequences (McGrory et al. 1993). The overall mortality rate amongst victims of pediatric spinal trauma is approximately 16-41 % but considerably higher for the youngest ages (Platzer et al. 2007; Brown et al. 2001; Kokoska et al. 2001; Eleraky et al. 2000; Givens et al. 1996; Orenstein et al. 1994; Hamilton and Myles 1992b).

Complete prevalence of malignant primary brain tumors registry data in the United States compared with other common cancers, 2010

PubMed Central

Zhang, Adah S.; Ostrom, Quinn T.; Kruchko, Carol; Rogers, Lisa; Peereboom, David M.

2017-01-01

Abstract Background. Complete prevalence proportions illustrate the burden of disease in a population. This study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0–14 y), adolescent and young adult (AYA) (15–39 y), and adult (40+ y). Methods. Complete prevalence proportions were estimated using a novel regression method extended from the Completeness Index Method, which combines survival and incidence data from multiple sources. In this study, two datasets, CBTRUS and SEER, were used to calculate complete prevalence estimates of interest. Results. Complete prevalence for malignant primary brain tumors was 47.59/100000 population (22.31, 48.49, and 57.75/100000 for child, AYA, and adult populations). The most prevalent cancers by age were childhood leukemia (36.65/100000), AYA melanoma of the skin (66.21/100000), and adult female breast (1949.00/100000). The most prevalent CBTRUS histologies in children and AYA were pilocytic astrocytoma (6.82/100000, 5.92/100000), and glioblastoma (12.76/100000) in adults. Conclusions. The relative impact of malignant primary brain tumors is higher among children than any other age group; it emerges as the second most prevalent cancer among children. Complete prevalence estimates for primary malignant brain tumors fills a gap in overall cancer knowledge, which provides critical information toward public health and health care planning, including treatment, decision making, funding, and advocacy programs. PMID:28039365

A Multi-faceted Approach to Improving Breast Cancer Outcomes in a Rural Population, and the Potential Impact of Patient Navigation.

PubMed

Petereit, Daniel; Omidpanah, Adam; Boylan, Amy; Kussman, Patricia; Baldwin, Denise; Banik, Deborah; Minton, Mary; Eastmo, Eric; Clemments, Paul; Guadagnolo, B Ashleigh

2016-06-01

The mastectomy rate in rural areas of the Northern Plains of the U.S. was 64 percent from 2000 through 2005. We implemented a breast cancer patient navigation (BPN) program in May 2007 to increase breast conservation (BC) rates. We analyzed mastectomy and BC rates among our 1,466 patients with either ductal carcinoma in situ (DCIS) or stage I/II invasive breast cancer treated from 2000 through 2012. We used interrupted time series (ITS) to compare rates in treatment following implementation of BPN. In addition, breast conservation rates were compared to population data from the Surveillance, Epidemiology, and End Results (SEER) database. The BC rates were 56 percent for navigated patients versus 37 percent for non-navigated patients (95 percent CI for difference: 14.8 to 25.6 percent). There was a consistent annual increase in treatment with BC versus a mastectomy (+2.9 percent/year, p-trend < 0.001). The BC rate of 60 percent in 2012 now mirrors those observed in the SEER database. The ITS did not find that the change in BC rates over time was significantly attributable to implementation of the BPN. Other secular trends may have contributed to the change in BC rates over time. A number of factors may have contributed to an increase of BC rates over time, including physician and patient education, more radiation therapy options, and possibly a dedicated breast cancer PN program. This analysis demonstrates that overall breast cancer care among this rural and medically-underserved population is improving in our region and now parallels other regions of the country.

Bayesian pretest probability estimation for primary malignant bone tumors based on the Surveillance, Epidemiology and End Results Program (SEER) database.

PubMed

Benndorf, Matthias; Neubauer, Jakob; Langer, Mathias; Kotter, Elmar

2017-03-01

In the diagnostic process of primary bone tumors, patient age, tumor localization and to a lesser extent sex affect the differential diagnosis. We therefore aim to develop a pretest probability calculator for primary malignant bone tumors based on population data taking these variables into account. We access the SEER (Surveillance, Epidemiology and End Results Program of the National Cancer Institute, 2015 release) database and analyze data of all primary malignant bone tumors diagnosed between 1973 and 2012. We record age at diagnosis, tumor localization according to the International Classification of Diseases (ICD-O-3) and sex. We take relative probability of the single tumor entity as a surrogate parameter for unadjusted pretest probability. We build a probabilistic (naïve Bayes) classifier to calculate pretest probabilities adjusted for age, tumor localization and sex. We analyze data from 12,931 patients (647 chondroblastic osteosarcomas, 3659 chondrosarcomas, 1080 chordomas, 185 dedifferentiated chondrosarcomas, 2006 Ewing's sarcomas, 281 fibroblastic osteosarcomas, 129 fibrosarcomas, 291 fibrous malignant histiocytomas, 289 malignant giant cell tumors, 238 myxoid chondrosarcomas, 3730 osteosarcomas, 252 parosteal osteosarcomas, 144 telangiectatic osteosarcomas). We make our probability calculator accessible at http://ebm-radiology.com/bayesbone/index.html . We provide exhaustive tables for age and localization data. Results from tenfold cross-validation show that in 79.8 % of cases the pretest probability is correctly raised. Our approach employs population data to calculate relative pretest probabilities for primary malignant bone tumors. The calculator is not diagnostic in nature. However, resulting probabilities might serve as an initial evaluation of probabilities of tumors on the differential diagnosis list.

Cognitive and Neural Sciences Division, 1988 Programs.

ERIC Educational Resources Information Center

Vaughan, Willard S., Ed.

The research and development efforts performed by principal investigators under sponsorship of the Office of Naval Research Cognitive and Neural Sciences Division during 1988 are documented. The title, name and affiliation of the principal investigator, project code, contract number, current end date, technical objective, approach, and progress of…

Joint University Program for Air Transportation Research, 1988-1989

NASA Technical Reports Server (NTRS)

Morrell, Frederick R. (Compiler)

1990-01-01

The research conducted during 1988 to 1989 under the NASA/FAA-sponsored Joint University Program for Air Transportation Research is summarized. The Joint University Program is a coordinated set of three grants sponsored by NASA Langley Research Center and the Federal Aviation Administration, one each with the Massachusetts Institute of Technology, Ohio University, and Princeton University. Completed works, status reports, and annotated bibliographies are presented for research topics, which include computer science, guidance and control theory and practice, aircraft performance, flight dynamics, and applied experimental psychology. An overview of the year's activities for each university is also presented.

Socioeconomic inequalities in hospital births in China between 1988 and 2008.

PubMed

Feng, Xing Lin; Xu, Ling; Guo, Yan; Ronsmans, Carine

2011-06-01

To assess trends in hospital births in China during 1988-2008 in an effort to determine if efforts to overcome financial barriers to giving birth in hospital have reduced the access gap between the rich and the poor. Cross-sectional data obtained from four National Health Service Surveys were used to determine trends in hospital births during 1988-2008. Crude and adjusted annual rates were calculated by means of Poisson regression and were used to define trends across socioeconomic regions and households in different income quintiles. In 2008 women throughout China were giving birth in hospital almost universally except in region IV, the most remote rural region, where the percentage of hospital births was only 60.8. Hospital births in this region had increased steadily before 2002, but after that year the upward trend slowed down. During 1988-2001 the average yearly increase had been 21%, but in 2002-2008 it dropped to 10% (P = 0.0031). Inequalities between socioeconomic regions were greater than among individual households belonging to different income strata. By 2008 the difference between low- and high-income households in the proportion of hospital births had become very small (96.1% and 87.7% of high- and low-income households, respectively, gave birth in hospital that year). Most Chinese women now give birth in hospital, but the poorest rural region is still lagging behind. A more active and comprehensive approach will be needed to increase hospital births in these remote, hard-to-reach populations.

Development of Liposome Encapsulated Hemoglobin (LEH) and Studies of Hemorrhagic Shock by Use of Imaging Studies with Oxygen-15 and Other Radiotracers

DTIC Science & Technology

2004-09-01

hemoglobin in the oxy-hemoglobin state [Stratton 1988; Takeoka 1997]. 3) Decreased Vasoactivity. Because LEH has physical properties closer to red cells...in rabbit arterial segments. J Appl Physiol 82:1826-1835. [21] Sakai H, Horinouchi H, Masada Y, Takeoka S, Ikeda E, Takaori M, Kobayashi K and...4317-4325. [22] Sakai H, Horinouchi H, Tomiyama K, Ikeda E, Takeoka S, Kobayashi K and Tsuchida E (2001) Hemoglobin-vesicles as oxygen carriers

49 CFR 565.25 - Content requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... for VIN Year Code 1980 A 1981 B 1982 C 1983 D 1984 E 1985 F 1986 G 1987 H 1988 J 1989 K 1990 L 1991 M 1992 N 1993 P 1994 R 1995 S 1996 T 1997 V 1998 W 1999 X 2000 Y 2001 1 2002 2 2003 3 2004 4 2005 5 2006... J = 1 K = 2 L = 3 M = 4 N = 5 P = 7 R = 9 S = 2 T = 3 U = 4 V = 5 W = 6 X = 7 Y = 8 Z = 9 (2...

National Aviation Security Policy, Strategy, and Mode-Specific Plans: Background and Considerations for Congress

DTIC Science & Technology

2008-01-02

aviation security . The approach to aviation security was largely shaped by past events, such as the bombing of Pan Am flight 103 in December 1988, rather...2001 attacks, U.S. aviation security policy and strategy was closely linked to the changes called for in the Aviation and Transportation Security Act...sensitive thus limiting public discourse on the DHS strategy for aviation security . However, in June 2006 President Bush directed the DHS to establish and

Observations of cancer incidence surveillance in Duluth, Minnesota.

PubMed Central

Sigurdson, E E

1983-01-01

In 1973, amphibole asbestos fibers were discovered in the municipal water supply of Duluth, Minnesota. The entire city population of approximately 100,000 was exposed from the late 1950s through 1976 at levels of 1-65 million fibers per liter of water. Because of previous epidemiologic studies that linked mesothelioma, lung and gastrointestinal cancers to occupational exposure to asbestos, surveillance of cancer incidence in residents of Duluth was initiated to determine the health effect from ingestion of asbestos. The methodology of the Third National Cancer Survey (TNCS) and SEER Program was used. Duluth 1969-1971 rates were compared with TNCS rates for the cities of Minneapolis and St. Paul during 1969-1971; Duluth rates during 1974-1976 are compared with Duluth 1969-1971; Duluth rates during 1979-1980 are compared with Duluth 1969-1971 and with Iowa SEER; and a table of the occurrence of malignant mesothelioma is presented. Statistically significant excesses are observed in several primary sites in Duluth residents. However, lung cancer in Duluth females is the only primary site considered also of biological significance. The mesothelioma incidence rate is no more than expected. This paper also describes the problems of long-term surveillance of exposed populations considered at risk of environment cancer, the need for improved study methodologies and the use of federal records for follow up of exposed individuals. PMID:6662096

American-Indian diabetes mortality in the Great Plains Region 2002–2010

PubMed Central

Kelley, Allyson; Giroux, Jennifer; Schulz, Mark; Aronson, Bob; Wallace, Debra; Bell, Ronny; Morrison, Sharon

2015-01-01

Objective To compare American-Indian and Caucasian mortality rates from diabetes among tribal Contract Health Service Delivery Areas (CHSDAs) in the Great Plains Region (GPR) and describe the disparities observed. Research design and methods Mortality data from the National Center for Vital Statistics and Seer*STAT were used to identify diabetes as the underlying cause of death for each decedent in the GPR from 2002 to 2010. Mortality data were abstracted and aggregated for American-Indians and Caucasians for 25 reservation CHSDAs in the GPR. Rate ratios (RR) with 95% CIs were used and SEER*Stat V.8.0.4 software calculated age-adjusted diabetes mortality rates. Results Age-adjusted mortality rates for American-Indians were significantly higher than those for Caucasians during the 8-year period. In the GPR, American-Indians were 3.44 times more likely to die from diabetes than Caucasians. South Dakota had the highest RR (5.47 times that of Caucasians), and Iowa had the lowest RR, (1.1). Reservation CHSDA RR ranged from 1.78 to 10.25. Conclusions American-Indians in the GPR have higher diabetes mortality rates than Caucasians in the GPR. Mortality rates among American-Indians persist despite special programs and initiatives aimed at reducing diabetes in these populations. Effective and immediate efforts are needed to address premature diabetes mortality among American-Indians in the GPR. PMID:25926992

Lung Cancer Survival Prediction using Ensemble Data Mining on Seer Data

DOE PAGES

Agrawal, Ankit; Misra, Sanchit; Narayanan, Ramanathan; ...

2012-01-01

We analyze the lung cancer data available from the SEER program with the aim of developing accurate survival prediction models for lung cancer. Carefully designed preprocessing steps resulted in removal/modification/splitting of several attributes, and 2 of the 11 derived attributes were found to have significant predictive power. Several supervised classification methods were used on the preprocessed data along with various data mining optimizations and validations. In our experiments, ensemble voting of five decision tree based classifiers and meta-classifiers was found to result in the best prediction performance in terms of accuracy and area under the ROC curve. We have developedmore » an on-line lung cancer outcome calculator for estimating the risk of mortality after 6 months, 9 months, 1 year, 2 year and 5 years of diagnosis, for which a smaller non-redundant subset of 13 attributes was carefully selected using attribute selection techniques, while trying to retain the predictive power of the original set of attributes. Further, ensemble voting models were also created for predicting conditional survival outcome for lung cancer (estimating risk of mortality after 5 years of diagnosis, given that the patient has already survived for a period of time), and included in the calculator. The on-line lung cancer outcome calculator developed as a result of this study is available at http://info.eecs.northwestern.edu:8080/LungCancerOutcomeCalculator/.« less

Report on National Collegiate Alcohol Awareness Week, Fall 1988.

ERIC Educational Resources Information Center

Rapaport, Ross J.

This document presents a report of the education and prevention activities undertaken at Central Michigan University in Mt. Pleasant, Michiagn, during the fall semester of 1988, in recognition of National Collegiate Alcohol Awareness Week (NCAAW). The document begins with a brief review of the university's campus-wide programs, goals, and…

Directory of Awards. Fiscal Years 1987 and 1988.

ERIC Educational Resources Information Center

National Science Foundation, Washington, DC. Directorate for Science and Engineering Education.

The National Science Foundation (NSF) provides awards for education and research in the sciences, mathematics, and engineering. This publication contains information about awards for the 1987 and 1988 fiscal years. An introductory section reviews the goals of NSF's education program and the long-range goals of the Directorate for Science and…

The 1988 CDA National Survey Results.

ERIC Educational Resources Information Center

Council for Early Childhood Professional Recognition, Washington, DC.

A 44-item questionnare was sent to 11,000 Child Development Associates in the fall of 1988 in an effort to provide an updated view of the constituency served by the Child Development Association (CDA) National Credentialing Program. The questionnaire covered four categories: (1) background information; (2) education and experience; (3) training…

California Latina/Latino Demographic Data Book. A Policy Research Program Report.

ERIC Educational Resources Information Center

Gey, Fredric C.; And Others

This report presents demographic data on California's Latino population. Data sources include census reports from 1980 and 1990; the 1990 Annual Demographic File; the 1990 and 1988 Voter Supplements; and the 1988 Fertility, Birth Expectation, and Immigration Study. The report includes the following information: (1) general demographic statistics…

Space directorate research and technology accomplishments for FY 1988

NASA Technical Reports Server (NTRS)

Avery, Don E. (Compiler)

1989-01-01

The major accomplishments and test highlights for FY 1988 that occurred in the Space Dirctorate are given. Accomplishments and test highlights are presented by Division and Branch. The presented information will be useful in program coordination with government organizations, universities, and industry in areas of mutual interest.

Heating Efficiency of Beat Wave Excitation in a Density Gradient,

DTIC Science & Technology

1988-02-01

and Technology, January 1988. PPG-1124 񓟣 Research Highlights in The Pisces Program," R.V. Conn, et al, January 1988. PPG-1125 "Magnetic Fusion ... Energy , vol. 5. Technical Assessement of Critical Issues in the Steady State Operation of Fusion Confinement Devices," D. M. Goebel, Assessment Chairman

76 FR 11435 - Privacy Act of 1974; Computer Matching Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

... Security Administration. SUMMARY: Pursuant to the Computer Matching and Privacy Protection Act of 1988, Public Law 100-503, the Computer Matching and Privacy Protections Amendments of 1990, Pub. L. 101-508... Interpreting the Provisions of Public Law 100-503, the Computer Matching and Privacy Protection Act of 1988...

Program and Abstracts of the National Meeting of the Society for Leukocyte Biology (25th) Held in Washington, DC on October 27-30, 1988. Journal of Leukocyte Biology. Volume 44, Number 4

DTIC Science & Technology

1988-10-01

C.P. Schaffner. Waksman Institute of Microbiology @ Rutgers-The State University, New Brunswick, NJ 08855-0759. 242 1988 Annual Meeting Program...Eierman, C. Johnson and S. Haskill. Depts. of Microbiology and Immunology, Ub/Gyn, and Lineberger Cancer Research Center, Univ. of North Carolina...ING. Mary Haak-Frendscho, Charles J. Czuprynski and Donna M. Paulnock. Depts. Medical Microbiology and Pathobiology Sciences, University Wisconsin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawrence, G.B.; Fernandez, I.J.; Goltz, S.M.

To provide information needed to assess the current and future status of spruce-fir forests in Maine, the Howland Integrated Forest Study (HIFS) was initiated in 1987 as part of the USDA Forest Service Forest Response Program, in conjunction with the establishment of a Mountain Cloud Chemistry Program (MCCP) monitoring site. Through this project, bulk and wet-only precipitation, dry deposition, throughfall and soil solution chemistry has been determined. This paper will focus on soil solution collected between May, 1988 and bulk precipitation collected from June through November, 1988.

Water-resources activities in Utah by the U.S. Geological Survey, October 1, 1988, to September 30, 1989

USGS Publications Warehouse

Gates, Joseph S.; Dragos, Stefanie L.

1990-01-01

This report contains summaries of the progress of water-resources studies in Utah by the U.S. Geological Survey, Water Resources Division, Utah District, from October 1, 1988, to September 30, 1989. The program in Utah during this period consisted of 21 projects; a discussion of each project is given in the main body of the report. The following sections outline the basic mission and program of the Water Resources Division, the organizational structure of the Utah District, the distribution of District funding in terms of source of funds and type of activity funded, and the agencies with which the District cooperates. The last part of the introduction is a list of reports produced by the District from October 1988 to September 1989.

Mortality risk from comorbidities independent of triple-negative breast cancer status: NCI-SEER-based cohort analysis.

PubMed

Swede, Helen; Sarwar, Amna; Magge, Anil; Braithwaite, Dejana; Cook, Linda S; Gregorio, David I; Jones, Beth A; R Hoag, Jessica; Gonsalves, Lou; L Salner, Andrew; Zarfos, Kristen; Andemariam, Biree; Stevens, Richard G; G Dugan, Alicia; Pensa, Mellisa; A Brockmeyer, Jessica

2016-05-01

A comparatively high prevalence of comorbidities among African-American/Blacks (AA/B) has been implicated in disparate survival in breast cancer. There is a scarcity of data, however, if this effect persists when accounting for the adverse triple-negative breast cancer (TNBC) subtype which occurs at threefold the rate in AA/B compared to white breast cancer patients. We reviewed charts of 214 white and 202 AA/B breast cancer patients in the NCI-SEER Connecticut Tumor Registry who were diagnosed in 2000-2007. We employed the Charlson Co-Morbidity Index (CCI), a weighted 17-item tool to predict risk of death in cancer populations. Cox survival analyses estimated hazard ratios (HRs) for all-cause mortality in relation to TNBC and CCI adjusting for clinicopathological factors. Among patients with SEER local stage, TNBC increased the risk of death (HR 2.18, 95 % CI 1.14-4.16), which was attenuated when the CCI score was added to the model (Adj. HR 1.50, 95 % CI 0.74-3.01). Conversely, the adverse impact of the CCI score persisted when controlling for TNBC (Adj. HR 1.49, 95 % CI 1.29-1.71; per one point increase). Similar patterns were observed in SEER regional stage, but estimated HRs were lower. AA/B patients with a CCI score of ≥3 had a significantly higher risk of death compared to AA/B patients without comorbidities (Adj. HR 5.65, 95 % CI 2.90-11.02). A lower and nonsignificant effect was observed for whites with a CCI of ≥3 (Adj. HR 1.90, 95 % CI 0.68-5.29). comorbidities at diagnosis increase risk of death independent of TNBC, and AA/B patients may be disproportionately at risk.

Management and Survival Patterns of Patients with Gliomatosis Cerebri: A SEER-Based Analysis.

PubMed

Carroll, Kate T; Hirshman, Brian; Ali, Mir Amaan; Alattar, Ali A; Brandel, Michael G; Lochte, Bryson; Lanman, Tyler; Carter, Bob; Chen, Clark C

2017-07-01

We used the SEER (Surveillance Epidemiology and End Results) database (1999-2010) to analyze the clinical practice patterns and overall survival in patients with gliomatosis cerebri (GC), or glioma involving 3 or more lobes of the cerebrum. We identified 111 patients (age ≥18 years) with clinically or microscopically diagnosed GC in the SEER database. Analyses were performed to determine clinical practice patterns for these patients and whether these practices were associated with survival. Fifty-eight percent of the 111 patients with GC received microscopic confirmation of their diagnosis. Of the remaining patients, 40% were diagnosed via imaging or laboratory tests, and 2% had unknown methods of diagnosis. Seven percent of patients who did not have microscopic confirmation of their diagnosis received radiation therapy. Radiation therapy and surgery were not associated with survival. The only variable significantly associated with overall survival was age at diagnosis. Patients aged 18-50 years showed improved survival relative to patients aged >50 years (median survival, 11 and 6 months, respectively; P = 0.03). For patients aged >50 years, improved overall survival was observed in the post-temozolomide era (2005-2010) relative to those treated in the pre-temozolomide era (1999-2004) (median survival, 9 and 4 months, respectively; P = 0.005). In the SEER database, ∼40% of the patients with glioma with imaging findings of GC do not receive microscopic confirmation of their diagnosis. We propose that tissue confirmation is warranted in patients with GC, because genomic analysis of these specimens may provide insights that will contribute to meaningful therapeutic intervention. Copyright © 2017 Elsevier Inc. All rights reserved.

A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes.

PubMed

Ali, Arif N; Switchenko, Jeffrey M; Kim, Sungjin; Kowalski, Jeanne; El-Deiry, Mark W; Beitler, Jonathan J

2014-11-15

The current study was conducted to develop a multifactorial statistical model to predict the specific head and neck (H&N) tumor site origin in cases of squamous cell carcinoma confined to the cervical lymph nodes ("unknown primaries"). The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for patients with an H&N tumor site who were diagnosed between 2004 and 2011. The SEER patients were identified according to their H&N primary tumor site and clinically positive cervical lymph node levels at the time of presentation. The SEER patient data set was randomly divided into 2 data sets for the purposes of internal split-sample validation. The effects of cervical lymph node levels, age, race, and sex on H&N primary tumor site were examined using univariate and multivariate analyses. Multivariate logistic regression models and an associated set of nomograms were developed based on relevant factors to provide probabilities of tumor site origin. Analysis of the SEER database identified 20,011 patients with H&N disease with both site-level and lymph node-level data. Sex, race, age, and lymph node levels were associated with primary H&N tumor site (nasopharynx, hypopharynx, oropharynx, and larynx) in the multivariate models. Internal validation techniques affirmed the accuracy of these models on separate data. The incorporation of epidemiologic and lymph node data into a predictive model has the potential to provide valuable guidance to clinicians in the treatment of patients with squamous cell carcinoma confined to the cervical lymph nodes. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.

Effect of marital status on the survival of patients with hepatocellular carcinoma treated with surgical resection: an analysis of 13,408 patients in the surveillance, epidemiology, and end results (SEER) database.

PubMed

Wu, Chao; Chen, Ping; Qian, Jian-Jun; Jin, Sheng-Jie; Yao, Jie; Wang, Xiao-Dong; Bai, Dou-Sheng; Jiang, Guo-Qing

2016-11-29

Marital status has been reported as an independent prognostic factor for survival in various cancers, but it has been rarely studied in hepatocellular carcinoma (HCC) treated by surgical resection. We retrospectively investigated Surveillance, Epidemiology, and End Results (SEER) population-based data and identified 13,408 cases of HCC with surgical treatment between 1998 and 2013. The patients were categorized according to marital status, as "married," "never married," "widowed," or "divorced/separated." The 5-year HCC cause-specific survival (HCSS) data were obtained, and Kaplan-Meier methods and multivariate Cox regression models were used to ascertain whether marital status is also an independent prognostic factor for survival in HCC. Patients in the widowed group had the higher proportion of women, a greater proportion of older (>60 years) patients, more frequency in latest year of diagnosis (2008-2013), a greater number of tumors at TNM stage I/II, and more prevalence at localized SEER Stage, all of which were statistically significant within-group comparisons (P < 0.001). Marital status was demonstrated to be an independent prognostic factor by multivariate survival analysis (P < 0.001). Married patients had better 5-year HCSS than did unmarried patients (46.7% vs 37.8%) (P < 0.001); conversely, widowed patients had lowest HCSS compared with all other patients, overall, at each SEER stage, and for different tumor sizes. Marital status is an important prognostic factor for survival in patients with HCC treated with surgical resection. Widowed patients have the highest risk of death compared with other groups.

Nomogram for predicting the benefit of neoadjuvant chemoradiotherapy for patients with esophageal cancer: a SEER-Medicare analysis.

PubMed

Eil, Robert; Diggs, Brian S; Wang, Samuel J; Dolan, James P; Hunter, John G; Thomas, Charles R

2014-02-15

The survival impact of neoadjuvant chemoradiotherapy (CRT) on esophageal cancer remains difficult to establish for specific patients. The aim of the current study was to create a Web-based prediction tool providing individualized survival projections based on tumor and treatment data. Patients diagnosed with esophageal cancer between 1997 and 2005 were selected from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database. The covariates analyzed were sex, T and N classification, histology, total number of lymph nodes examined, and treatment with esophagectomy or CRT followed by esophagectomy. After propensity score weighting, a log-logistic regression model for overall survival was selected based on the Akaike information criterion. A total of 824 patients with esophageal cancer who were treated with esophagectomy or trimodal therapy met the selection criteria. On multivariate analysis, age, sex, T and N classification, number of lymph nodes examined, treatment, and histology were found to be significantly associated with overall survival and were included in the regression analysis. Preoperative staging data and final surgical margin status were not available within the SEER-Medicare data set and therefore were not included. The model predicted that patients with T4 or lymph node disease benefitted from CRT. The internally validated concordance index was 0.72. The SEER-Medicare database of patients with esophageal cancer can be used to produce a survival prediction tool that: 1) serves as a counseling and decision aid to patients and 2) assists in risk modeling. Patients with T4 or lymph node disease appeared to benefit from CRT. This nomogram may underestimate the benefit of CRT due to its variable downstaging effect on pathologic stage. It is available at skynet.ohsu.edu/nomograms. © 2013 American Cancer Society.

Effects of sex on the incidence and prognosis of spinal meningiomas: a Surveillance, Epidemiology, and End Results study.

PubMed

Westwick, Harrison J; Shamji, Mohammed F

2015-09-01

Most spinal meningiomas are intradural lesions in the thoracic spine that present with both local pain and myelopathy. By using the large prospective Surveillance, Epidemiology, and End Results (SEER) database, the authors studied the incidence of spinal meningiomas and examined demographic and treatment factors predictive of death. Using SEER*Stat software, the authors queried the SEER database for cases of spinal meningioma between 2000 and 2010. From the results, tumor incidence and demographic statistics were computed; incidence was analyzed as a function of tumor location, pathology, age, sex, and malignancy code. Survival was analyzed by using a Cox proportional hazards ratio in SPSS for age, sex, marital status, primary site, size quartile, treatment modality, and malignancy code. In this analysis, significance was set at a p value of 0.05. The 1709 spinal meningiomas reported in the SEER database represented 30.7% of all primary intradural spinal tumors and 7.9% of all meningiomas. These meningiomas occurred at an age-adjusted incidence of 0.193 (95% CI 0.183-0.202) per 100,000 population and were closely related to sex (337 [19.7%] male patients and 1372 [80.3%] female patients). The Cox hazard function for mortality in males was higher (2.4 [95% CI1.7-3.5]) and statistically significant, despite the lower lesion incidence in males. All-cause survival was lowest in patients older than 80 years. Primary site and treatment modality were not significant predictors of mortality. Spinal meningiomas represent a significant fraction of all primary intradural spinal tumors and of all meningiomas. The results of this study establish the association of lesion incidence and survival with sex, with a less frequent incidence in but greater mortality among males.

Impact of aging on host immune response and survival in melanoma: an analysis of 3 patient cohorts.

PubMed

Weiss, Sarah A; Han, Joseph; Darvishian, Farbod; Tchack, Jeremy; Han, Sung Won; Malecek, Karolina; Krogsgaard, Michelle; Osman, Iman; Zhong, Judy

2016-10-19

Age has been reported as an independent prognostic factor for melanoma-specific survival (MSS). We tested the hypothesis that age impacts the host anti-tumor immune response, accounting for age-specific survival outcomes in three unique melanoma patient cohorts. We queried the U.S. population-based Surveillance, Epidemiology, and End Results Program (SEER), the prospective tertiary care hospital-based Interdisciplinary Melanoma Cooperative Group (IMCG) biorepository, and the Cancer Genome Atlas (TCGA) biospecimen database to test the association of patient age at time of melanoma diagnosis with clinicopathologic features and survival outcomes. Age groups were defined as ≤45 (young), 46-65 (intermediate), and >65 (older). Each age group in the IMCG and TCGA cohorts was stratified by tumor infiltrating lymphocyte (TIL) measurements and tested for association with MSS. Differential expression of 594 immunoregulatory genes was assessed in a subset of primary melanomas in the IMCG and TCGA cohorts using an integrative pathway analysis. We analyzed 304, 476 (SEER), 1241 (IMCG), and 292 (TCGA) patients. Increasing age at melanoma diagnosis in both the SEER and IMCG cohorts demonstrated a positive correlation with tumor thickness, ulceration, stage, and mortality, however age in the TCGA cohort did not correlate with mortality. Older age was associated with shorter MSS in all three cohorts. When the young age group in both the IMCG and TCGA cohorts was stratified by TIL status, there were no differences in MSS. However, older IMCG patients with brisk TILs and intermediate aged TCGA patients with high lymphocyte scores (3-6) had improved MSS. Gene expression analysis revealed top pathways (T cell trafficking, communication, and differentiation) and top upstream regulators (CD3, CD28, IFNG, and STAT3) that significantly changed with age in 84 IMCG and 43 TCGA primary melanomas. Older age at time of melanoma diagnosis is associated with shorter MSS, however age's association with clinicopathologic features is dependent upon specific characteristics of the study population. TIL as a read-out of the host immune response may have greater prognostic impact in patients older than age 45. Recognition of age-related factors negatively impacting host immune responses may provide new insights into therapeutic strategies for the elderly.

Cutaneous soft tissue sarcoma incidence patterns in the U.S. : an analysis of 12,114 cases.

PubMed

Rouhani, Panta; Fletcher, Christopher D M; Devesa, Susan S; Toro, Jorge R

2008-08-01

Cutaneous soft tissue sarcomas (CSTS) are a heterogeneous group of mesenchymal neoplasms. To the authors' knowledge, no prior large, population-based study has focused on CSTS. Surveillance, Epidemiology, and End Results (SEER) Program incidence and relative survival rates of CSTS were analyzed according to race, sex, and histologic type using the 2002 criteria of the World Health Organization classification. Among residents of the 13 SEER registries, 12,114 CSTS were diagnosed from 1992 through 2004. Overall age-adjusted CSTS incidence rates were highest among blacks (30.8 per 1,000,000 person-years) followed by whites (25 per 1,000,000 person-years), and American Indians/Alaska Natives (11.2 per 1,000,000 person-years) and were lowest among Asian/Pacific Islanders (7.7 per 1,000,000 person-years). Kaposi sarcoma (KS) accounted for 71.1% of cases, and the rates were similarly ranked. Dermatofibrosarcoma protuberans (DFSP) rates also were highest among blacks, whereas leiomyosarcoma (LS) and angiosarcoma (AS) rates were highest among whites. The rate ratio of men to women was 25.5 for KS, 4.7 for malignant fibrous histiocytoma (MFH), 3.7 for LS, 2.0 for AS, and 0.9 for DFSP. The 5-year relative survival rates were 99% for patients with DFSP, 89% for patients with MFH, 92% for patients with LS, and 45% for patients with AS. KS rates among men in the original 9 SEER registries increased more than 30-fold during the 1980s before they peaked around 1991 and subsequently declined rapidly because of human immunodeficiency virus-associated KS and highly active antiretroviral therapy. This KS pattern was evident not only among those ages 20 to 59 years but also among those ages 60 to 69 years. From 1978 through 2004, LS and AS rates among whites increased exponentially. CSTS rates varied markedly over time and by race, sex, and histologic type, supporting the notion that these histologic variants of CSTS areetiologically distinct. (c) 2008 American Cancer Society

Prediction of lung cancer patient survival via supervised machine learning classification techniques.

PubMed

Lynch, Chip M; Abdollahi, Behnaz; Fuqua, Joshua D; de Carlo, Alexandra R; Bartholomai, James A; Balgemann, Rayeanne N; van Berkel, Victor H; Frieboes, Hermann B

2017-12-01

Outcomes for cancer patients have been previously estimated by applying various machine learning techniques to large datasets such as the Surveillance, Epidemiology, and End Results (SEER) program database. In particular for lung cancer, it is not well understood which types of techniques would yield more predictive information, and which data attributes should be used in order to determine this information. In this study, a number of supervised learning techniques is applied to the SEER database to classify lung cancer patients in terms of survival, including linear regression, Decision Trees, Gradient Boosting Machines (GBM), Support Vector Machines (SVM), and a custom ensemble. Key data attributes in applying these methods include tumor grade, tumor size, gender, age, stage, and number of primaries, with the goal to enable comparison of predictive power between the various methods The prediction is treated like a continuous target, rather than a classification into categories, as a first step towards improving survival prediction. The results show that the predicted values agree with actual values for low to moderate survival times, which constitute the majority of the data. The best performing technique was the custom ensemble with a Root Mean Square Error (RMSE) value of 15.05. The most influential model within the custom ensemble was GBM, while Decision Trees may be inapplicable as it had too few discrete outputs. The results further show that among the five individual models generated, the most accurate was GBM with an RMSE value of 15.32. Although SVM underperformed with an RMSE value of 15.82, statistical analysis singles the SVM as the only model that generated a distinctive output. The results of the models are consistent with a classical Cox proportional hazards model used as a reference technique. We conclude that application of these supervised learning techniques to lung cancer data in the SEER database may be of use to estimate patient survival time with the ultimate goal to inform patient care decisions, and that the performance of these techniques with this particular dataset may be on par with that of classical methods. Copyright © 2017 Elsevier B.V. All rights reserved.

Stage Presentation, Care Patterns, and Treatment Outcomes for Squamous Cell Carcinoma of the Penis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burt, Lindsay M.; Shrieve, Dennis C.; Tward, Jonathan D., E-mail: Jonathan.Tward@hci.utah.edu

Purpose: Penile squamous cell carcinoma (SCC) is a rare entity, with few published series on outcomes. We evaluated the stage distributions and outcomes for surgery and radiation therapy in a U.S. population database. Methods and Materials: Subjects with SCC of the penis were identified using the National Cancer Institute Surveillance, Epidemiology and End Results (SEER) Program database between 1988 and 2006. Descriptive statistics were performed, and cause-specific survival (CSS) was estimated using Kaplan-Meier analysis. Comparisons of treatment modalities were analyzed using multivariate Cox regression. Subjects were staged using American Joint Committee on Cancer, sixth edition, criteria. Results: There were 2458more » subjects identified. The median age was 66.8 years (range, 17-102 years). Grade 2 disease was present in 94.5% of cases. T1, T2, T3, T4, and Tx disease was present in 64.8%, 17.1%, 9.5%, 2.1%, and 6.5% of cases, respectively. N0, N1, N2, N3, and Nx disease was noted in 61.6%, 6.9%, 4.0%, 3.7%, and 23.8% of cases, respectively. M1 disease was noted in 2.5% of subjects. Individuals of white ethnicity accounted for 85.1% of cases. Lymphadenectomy was performed in 16.7% of cases. The CSS for all patients at 5 and 10 years was 80.8% and 78.6%. By multivariable analysis grades 2 and 3 disease, T3 stage, and positive lymph nodes were adverse prognostic factors for CSS. Conclusion: SCC of the penis often presents as early-stage T1, N0, M0, grade 1, or grade 2 disease. The majority of patients identified were treated with surgery, and only a small fraction of patients received radiation therapy alone or as adjuvant therapy.« less

Development of comprehensive nomograms for evaluating overall and cancer-specific survival of laryngeal squamous cell carcinoma patients treated with neck dissection

PubMed Central

Shi, Xiao; Hu, Wei-ping; Ji, Qing-hai

2017-01-01

Background Neck dissection for laryngeal squamous cell carcinoma (LSCC) patients could provide complementary prognostic information for AJCC N staging, like lymph node ratio (LNR). The aim of this study was to develop effective nomograms to better predict survival for LSCC patients treated with neck dissection. Results 2752 patients were identified and randomly divided into training (n = 2477) and validation (n = 275) cohorts. The 3- and 5-year probabilities of cancer-specific mortality (CSM) were 30.1% and 37.2% while 3- and 5-year death resulting from other causes (DROC) rate were 6.2% and 11.3%, respectively. 13 significant prognostic factors including LNR for overall (OS) and 12 (except race) for CSS were enrolled in the nomograms. Concordance index as a commonly used indicator of predictive performance, showed the nomograms had superiority over the no-LNR models and TNM classification (Training-cohort: OS: 0.713 vs 0.703 vs 0.667, CSS: 0.725 vs 0.713 vs 0.688; Validation-cohort: OS: 0.704 vs 0.690 vs 0.658, cancer-specific survival (CSS): 0.709 vs 0.693 vs 0.672). All calibration plots revealed good agreement between nomogram prediction and actual survival. Materials and Methods We identified LSCC patients undergoing neck dissection diagnosed between 1988 and 2008 from Surveillance, Epidemiology, and End Results (SEER) database. Optimal cutoff points were determined by X-tile program. Cumulative incidence function was used to analyze cancer-specific mortality (CSM) and death resulting from other causes (DROC). Significant predictive factors were used to establish nomograms estimating overall (OS) and cancer-specific survival (CSS). The nomograms were bootstrapped validated both internally and externally. Conclusions Comprehensive nomograms were constructed to predict OS and CSS for LSCC patients treated with neck dissection more accurately. PMID:28430613

Descriptive characteristics of prostate cancer in patients with a history of primary male breast cancer - a SEER analysis.

PubMed

Abhyankar, Nikita; Hoskins, Kent F; Abern, Michael R; Calip, Gregory S

2017-09-25

Current evidence on risk of prostate cancer following a diagnosis of male breast cancer is limited and guidance for screening in this potentially higher-risk population remainsunclear. Our objective was to quantify prostate cancer risk in men diagnosed with breast cancer. We identified men diagnosed with first primary breast cancer between 1988 and 2012 using the Surveillance, Epidemiology and End Results Program registry databases. Men were followed for occurrence of a second primary prostate cancer and secondary outcomes of cancer-specific and overall survival. Stratified analyses were performed by age, breast cancer stage, race, and breast cancer hormone receptor status. Excess risk per 10,000 person-years and standardized incidence ratios (SIR) with 95% confidence intervals (95% CI) were calculated. We used multivaraible Cox proportional hazard models to estimate hazard ratios (HR) and 95% CI for characteristics associated with secondary prostate cancer and survival. From a cohort of 5753 men with breast cancer with median follow up of 4.3 years, we identified 250 cases of second primary prostate cancer. Overall, the incidence of second primary prostate cancer was modestly greater than expected (SIR = 1.12, 95% CI 0.93-1.33), although not statistically significant. Stratified analyses demonstrated associations for men ages 65-74 at the time of breast cancer diagnosis (SIR = 1.34, 95%CI 1.01-1.73), hormone receptor-positive breast cancer (SIR = 1.23, 95%CI 1.11-1.39) or AJCC stage I breast cancer (SIR = 1.36, 95%CI 1.04-1.75) and second primary prostate cancer diagnosis. The incidence of prostate cancer in men with history of breast cancer is similar to the general population. Men with favorable characteristics of their breast cancer were more likely to develop prostate cancer, possibly due to a lower competing risk of breast cancer mortality.

Telecommunication and Technology Infrastructure Program (TTIP) Certification for Expenditures, Fiscal Year 2000-2001.

ERIC Educational Resources Information Center

Williams, Lindy

This document presents the guidelines for the California Community College 2000-2001 State-Funded Telecommunication and Technology Infrastructure Program (TTIP) Program. The 2000-2001 State Budget Act contains $44.3 million for expenditures on the TTIP. The Act provides that $31,600,000 be allocated to colleges for the following purposes: (1) data…

78 FR 22034 - Proposed Collection; Comment Request for Notice 2001-1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... Notice 2001-1, Employer-designed Tip Reporting Program for the Food and Beverage Industry (EmTRAC). DATES... Program for the Food and Beverage Industry (EmTRAC). OMB Number: 1545-1716. Notice Number: Notice 2001-1...

Chemical Technology Division: Progress report, January 1, 1987--June 30, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1989-02-01

This progress report summarizes the research and development efforts conducted in the Chemical Technology Division (Chem Tech) during the period January 1, 1987, to June 30, 1988. The following major areas are covered: waste management and environmental programs, radiochemical and reactor engineering programs, basic science and technology, Nuclear Regulatory Commission programs, and administrative resources and facilities. The Administrative Summary, an appendix, presents a comprehensive listing of publications, oral presentations, awards and recognitions, and patents of Chem Tech staff members during this period. A staffing level and financial summary and lists of seminars and Chem Tech consultants for the period aremore » also included.« less

Fiscal Year 1997-2000 transportation improvement program : air quality analysis : air quality conformity determination documentation for the Franklin, Delaware, and Licking County maintenance area

DOT National Transportation Integrated Search

1996-04-01

Under the Clean Air Act Amendments (CAAA) Franklin, Delaware and Licking : Counties were designated a marginal nonattainment area for ozone. This : designation was based on 1988 air quality data which violated the NAAQS for : ozone. Since 1988 year t...

Follow-Up Study of 1988 Nursing Graduates. Volume XVIII, No. 8.

ERIC Educational Resources Information Center

Dincher, J.; Meltesen, Cal

In 1989, a follow-up study of nursing program graduates was conducted at William Rainey Harper College (WRHC) to examine their employment patterns, further education plans, and evaluate particular aspects of their WRHC experience. Questionnaires were mailed to 105 nursing students who graduated in 1988. Results were compared with previous surveys…

Meeting the Challenge, 1988-89. Condition of Education in Connecticut: Elementary and Secondary.

ERIC Educational Resources Information Center

Connecticut State Board of Education, Hartford.

The condition of education in Connecticut, especially pertaining to reform efforts initiated from July 1, 1986, to June 30, 1988, is summarized in this biennial report. The document includes indepth discussions of the state's people and economy, teacher and administrator characteristics, student achievements, programs, and school finance. Text,…

A Handbook of the Workplace Literacy Project, 1988-90.

ERIC Educational Resources Information Center

Casasnovas-Bauer, Catherine; Thibodeau, Lynne

The Orange County (Florida) Public Schools Workplace Literacy Project is described. The program, established to meet the training needs of the growing hotel and restaurant industry in central Florida, has served over 1,000 primarily limited-English-proficient, immigrant students during the 18-month period of October 1988 through March 1990.…

Fulbright Hays Summer Seminars Abroad Program, 1988. Curriculum Projects.

ERIC Educational Resources Information Center

National Committee on United States-China Relations, New York, NY.

This document consists of a collection of 18 curriculum projects created by U.S. teachers after visiting China during 1988. The projects cover a variety of topics concerning China: "Chinese Living Environments" (R. Stumpe Brent); "China as a Model of a Mixed Economy in a Developing Nation" (G. Caressi); "Images of…

Project Nuevos Horizontes, 1988-89. OREA Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; And Others

In its fourth year, Project Nuevos Horizontes served 315 limited-English-speaking, native Spanish-speaking students in fall 1988 and 300 in spring 1989. The majority of participants came from the Dominican Republic and Puerto Rico. The program's goal was to provide students with the academic and support services needed to ensure completion of…

Children and Television. Current Issues in Education: A Bibliographic Series. Volume 5, No. 1, July 1988.

ERIC Educational Resources Information Center

Christo, Doris Hedlund

Focused on research concerning children and television, this annotated bibliography lists 44 articles selected from the Educational Resources Information Center (ERIC) database from 1983 to 1988. Topics include: (1) the effects of television violence on children; (2) television viewing patterns; (3) children's television programs; and (4)…

Combination of glazing, nisin treatment and radiation processing for shelf-life extension of seer fish (Scomberomorous guttatus) steaks

NASA Astrophysics Data System (ADS)

Kakatkar, Aarti S.; Gautam, Raj Kamal; Shashidhar, Ravindranath

2017-01-01

Fish and fishery products are most perishable. Combination of chilling with gamma irradiation, edible coatings, addition of antimicrobials etc has been applied to extend the shelf life. In the present study, a process to enhance the shelf life of seer fish (Scomberomorus guttatus) steaks using combination of coating prepared from gel dispersion of same fish; incorporated with nisin and gamma irradiation is described. A combination of glazing incorporated with nisin and irradiation at 2 kGy and 5 kGy increased the shelf life of the steaks from 7 days up to 34 and 42 days respectively on chilled storage.

Detection of damaged areas caused by the oil extraction in a steppe region using winter landsat imagery

NASA Astrophysics Data System (ADS)

Mjachina, Ksenya; Hu, Zhiyong; Chibilyev, Alexander

2018-01-01

Oil production in a steppe region disturbs the landscape and damages the steppe ecosystem. The objective of this research was to detect areas damaged by oil production in an oil field within the Russian Volga-Ural steppe region using winter Landsat imagery. We developed a practicable and effective approach using winter snow season multispectral Landsat satellite imagery. To this end, we applied seven algorithms of spectral or texture-based transformation: K-means, maximum likelihood estimation, topsoil grain size index, soil brightness, normalized differential snow index, tasselled cap, and co-occurrence measures. The co-occurrence texture measure variance shows the optimal result of identifying damaged areas. The unique feature of our method is that it can differentiate damaged areas from the bare soil of cropland within a cold steppe region where the area damaged by oil production is mixed with bare (fallow) croplands that have a polygonal shape similar to well pads. Such similarities can lead to confusion in object-based classification. Using the co-occurrence measures, we found that from 1988 to 2015, damaged area is nearly three times as big in the peak period of the oil field development (2001 and 2009) as in 1988. Landscape fragmentation also peaked in 2001 and 2009. Our approach for this project is useful and cost effective regular monitoring of damages from oil production for both the Volga-Ural steppe region and other cold steppe regions.

Citizens Utilities Company's successful residential new construction market transformation program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caulfield, T.O.; Shepherd, M.A.

1998-07-01

Citizens Utilities Company, Arizona Electric Division (CUC/AED) fielded a Residential New Construction Program (RNC) in the forth quarter of 1994 that had been designed from conception as a market transformation program. The CUC RNC Program encouraged builders to adopt energy efficient building practices for new homes by supplying builders estimates of energy savings, supplying inspections services to assist builders in applying energy efficient building practices while verifying compliance, and posting and promoting the home as energy efficient during the sales period. Measures generally required to qualify for the program were R-38 ceiling insulation, R-21 wall insulation, polysealing of all infiltrationmore » gaps during construction, well sealed air-conditioning ducts, and an air conditioner Seasonal Energy Efficiency Rating (SEER) of 11.0 or greater. In less than two years the program achieved over 17% market penetration without offering rebates to builders. This paper reviews the design of the program, including a discussion of the features felt to be primarily responsible for its success. It reviews the levels of penetration achieved, free-ridership, spillover, and market barriers encountered. Finally it proposes improvements to the program designed to carry it the next step toward a self-sustaining market transformation program.« less

Aquatic Plant Control Research Program: The Habitat Value of Aquatic Macrophytes for Macroinvertebrates

DTIC Science & Technology

1989-11-01

higan, provided almost t0 times more surface area for colo- ti: ; 1 ta; the total henthic a rea of the lake (losee and Vetzel 1988 ) . The .nportanco anWd...Galle Reservoir is not known, it is appareulL that they are ephemeral. In late May 1988 , several no-plant zones were marked with a stake. By August, all...place in the summers of 1986, 1987, and 1988 . Sampling in 1986 was preliminary and took place on 6 August in a P. rPosus bed located at site C (Figure

Proof of the Feasibility of Coherent and Incoherent Schemes for Pumping a Gamma-Ray Laser

DTIC Science & Technology

1988-10-01

TheUnierstyof Texas. at Dallas Center for’ "Quantum, Electronics The IGamm~a-7Ra~y.,La’ser. Project o Qua’rter’l y’ Report SJuly-September .1988 Co...Dallas Center for Quantum Electronics P.O. Box 830688 Richardson, Texas 75083-0688 October 1988 0 Quarterly Technical Progress Report 1 July 1988...ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASKAREA & WORK UNIT NUM9ERS University of Texas at Dallas Center for Quantum Electronics P.O. Box 830688

The Computer Software Rental Amendments Act of 1988. Hearing on S. 2727 before the Subcommittee on Patents, Copyrights and Trrademarks of the Committee on the Judiciary, United States Senate. One Hundredth Congress, Second Session (Provo, Utah, August 24, 1988).

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on the Judiciary.

A statement by Senator Orrin G. Hatch opened the hearing on The Computer Software Rental Amendments Act of 1988, a bill which would amend title 17, United States Code, the Copyright Act, to protect certain computer programs. The text of the bill is then presented, followed by the statements of four witnesses: (1) Dr. Alan C. Ashton, president,…

Landscape dynamics analysis of the Yongding River watershed (Mentougou section) by multi-temporal Landsat imagery

NASA Astrophysics Data System (ADS)

Zhang, Yuhu; Yu, Changqing; Qi, Jiaguo; Zhang, Zili; Shi, Qinshan

2007-11-01

The problem of efficient use of multi-temporal remotely sensed data for land-cover and landscape pattern dynamics has already considerable attention in landscape ecology and some other disciplines. This research develops and tests a methodological approach to monitor and analysis landscape dynamics change of Yongding river watershed (Mentougou section) as study area from 1988 to 2005, The result shows that the OIF is the best method of optimal bands selection in Landsat TM remote sensing data, TM3, 4, 5 bands is optimal band combination ;the Mentougou Reach of Yongding river watershed landscape changed significantly in terms of its composition over the period 1988-2005, The total landscape patches of study area in 2005 are more those in 1988,2001, Mean patch size(MPS)decreased sharply, Number of patches(NP) increased sharply, The landscape pattern takes on the fragmentation trends under the effect on the human activity. The forest (woodland and shrubland)are the main landscape matrix. with a significant decrease in croplands and a increase in built-up (residential, urban land) and industrial minerals mining land(coal, open-pit)over the 17 years, And the underlying socio-economic and other drivers of landscape change in study area are discussed.

23 years of managing diabetic ketoacidosis at Auckland Hospital

PubMed

Braatvedt, Geoffrey; Tekiteki, Amelia; Britton, Holly; Wallace, John; Khanolkar, Manish

2017-02-17

To examine the length of stay and need for intensive care of people admitted with diabetic ketoacidosis (DKA) to a single centre between 1988 and 2011. Patients aged ≥15 years admitted for the first time with DKA (plasma glucose ≥ 10mmol/L and a bicarbonate concentration ≤15mmol/L and a pH <7.35, and raised plasma or urine ketones or anion gap) to Auckland City Hospital from 1988-2011 were identified retrospectively. The patients were divided into four cohorts (1988-1996; 1997-2001; 2002-2006; 2007-2011). Over this time period there was no significant change to the insulin infusion protocol. There were 576 admissions with DKA in 388 people over the 23 years. The mean age of the patients and glucose concentration at presentation to hospital fell significantly over time. The admission pH and bicarbonate concentration was higher in more recent cohorts. The length of stay and need for intensive care admission fell significantly over time, but the number of patients subsequently readmitted with DKA remained high. In-hospital mortality remained low. DKA remains an important reason for admission to this hospital, but the severity of DKA at presentation has reduced over time. The need for intensive care admission and length of stay has fallen dramatically.

48 CFR 19.1001 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SMALL BUSINESS PROGRAMS Small Business Competitiveness Demonstration Program 19.1001 General. The Small Business Competitiveness Demonstration Program was established by the Small Business Competitiveness Demonstration Program Act of 1988, Public Law 100-656 (15 U.S.C. 644 note). The program is implemented by a...

Complications of intrauterine intravascular blood transfusion: lessons learned after 1678 procedures.

PubMed

Zwiers, C; Lindenburg, I T M; Klumper, F J; de Haas, M; Oepkes, D; Van Kamp, I L

2017-08-01

Maternal alloimmunization to fetal red-blood-cell antigens is a major cause of fetal anemia, which can lead to hydrops and perinatal death if untreated. The cornerstone of management during pregnancy is intrauterine intravascular blood transfusion (IUT). Although this procedure is considered relatively safe, complications continue to occur. The aim of this study was to evaluate rates of procedure-related complications and perinatal loss following IUT, and their change over time, in order to identify factors leading to improved outcome. This was a retrospective analysis of all IUTs for red-cell alloimmunization performed at the national referral center for fetal therapy in The Netherlands, from 1988 to 2015. Differences in complication rates and their associations with alterations in transfusion technique after 2001 were assessed. Between 1988 and 2015, 1678 IUTs were performed in 589 fetuses. For IUTs performed in 2001 and onwards, there was significant improvement in survival (88.6% vs 97.0%, P < 0.001) and a decline in procedure-related complications per fetus (9.8% vs 3.3%, P = 0.001) and per procedure (3.4% vs 1.2%, P = 0.003) compared with those performed before 2001. Procedure-related perinatal loss declined from 4.7% to 1.8% per fetus (P = 0.053). Beneficial changes in transfusion technique were routine use of fetal paralysis, increased use of intrahepatic transfusion and avoidance of arterial puncture. IUT has become an increasingly safe procedure in recent years when performed by experienced hands. The chosen technique should be fine-tuned according to the patient's individual situation. The declining complication rates are most likely related to center volume: this rare procedure is best performed in experienced fetal therapy centers. © 2016 Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. © 2016 Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Evaluating the Effectiveness of the 2000-2001 NASA "Why?" Files Program

NASA Technical Reports Server (NTRS)

Pinelli, Thomas E.; Frank, Kari Lou; Ashcroft, Scott B.; Williams, Amy C.

2002-01-01

NASA 'Why?' Files, a research and standards-based, Emmy-award winning series of 60-minute instructional programs for grades 3-5, introduces students to NASA; integrates mathematics, science, and technology by using Problem-Based Learning (PBL), scientific inquiry, and the scientific method; and motivates students to become critical thinkers and active problem solvers. All four 2000-2001 NASA 'Why?' Files programs include an instructional broadcast, a lesson guide, an interactive web site, plus numerous instructional resources. In March 2001, 1,000 randomly selected program registrants participated in a survey. Of these surveys, 185 (154 usable) met the established cut-off date. Respondents reported that (1) they used the four programs in the 2000-2001 NASA 'Why?' Files series; (2) series goals and objectives were met; (3) programs met national mathematics, science, and technology standards; (4) program content was developmentally appropriate for grade level; and (5) programs enhanced/enriched the teaching of mathematics, science, and technology.

Water Science and Technology Board annual report 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1989-01-01

This annual report of the Water Science and Technology Board (WSTB) summarizes the activities of the Board and its subgroups during 1988, its sixth year of existence. Included are descriptions of current and recently completed projects, new activities scheduled to begin in 1989, and plans for the future. The report also includes information on Board and committee memberships, program operational features, and reports produced during the past several years. This annual report is intended to provide an introduction to the WSTB and summary of its program for the year.

Report of the Secretary of Defense Caspar W. Weinberger to the Congress on the FY 1988/FY 1989 Budget and FY 1988-92 Defense Programs, January 12, 1987.

DTIC Science & Technology

1987-01-01

enough to sustain one wartime station overseas as well as satisfy training and maintenance needs. Advanced TacticalAir Reconnaissance System ( ATARS ...The ATARS is an umbrella concept for a series of upgrades in tactical reconnaissance capabilities. Major elements of the program include the Tactical...Funding Funding Funding E-3A Modifkation Development: $ Millions 105.2 96.8 110.7 88.4 Procurement: Quantity - - - - $ Millions .9 33.5 27.7 40.7 ATARS

Statistical Supplement to the Long-Range Planning for Texas Higher Education Report: Fiscal Year 1988, September 1, 1987-August 31, 1988.

ERIC Educational Resources Information Center

Texas Higher Education Coordinating Board, Austin.

This databook contains information on student enrollments, faculty, semester credit hours, physical facilities, appropriations, and student loan and grant programs for Texas institutions of higher education, including public and independent two- and four-year colleges. The enrollment section provides five-year (1983-87) summaries of headcount…

Journal of the American Association of Women in Community and Junior Colleges, 1988.

ERIC Educational Resources Information Center

Journal of the American Association of Women in Community and Junior Colleges, 1988

1988-01-01

Seeking to serve as an advocate for equity and excellence in community and junior colleges, this annual journal contains articles presenting research, model programs, and innovative ideas concerning women staff and students in two-year colleges. The 1988 issue contains the following articles: (1) "Moving Up: Advancement Strategies for Women in…

Choosing Optional Career Education. Project Choice 1988-89. OREA Report. Evaluation Section Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Plotkin, Donna

This report evaluates the implementation and outcome of the Elementary and Secondary Education Act Title VII program, Choosing Optional Infused Career Education (Project CHOICE) in Springfield Gardens High School in Queens (New York) and Fort Hamilton High School in Brooklyn (New York) for the 1988-89 school year. The project was created to combat…

Effects of Awareness and Legal Drinking Age on Alcohol Knowledge, Consumption, and Problems.

ERIC Educational Resources Information Center

Gonzalez, Gerardo M.

1991-01-01

Examined changes that occurred in alcohol consumption, alcohol knowledge, and alcohol-related problems among students attending major university between 1983 and 1988. Analyzed data from 353 questionnaires collected in 1983 and 254 in 1988. In spite of alcohol awareness program and change in state law raising drinking age to 21 in 1985, found no…

44 CFR 63.3 - Requirement to be covered by a contract for flood insurance by June 1, 1988.

Code of Federal Regulations, 2012 CFR

2012-10-01

... contract for flood insurance by June 1, 1988. 63.3 Section 63.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY INSURANCE AND HAZARD MITIGATION National Flood Insurance Program IMPLEMENTATION OF SECTION 1306(c) OF THE NATIONAL FLOOD INSURANCE ACT OF 1968 General § 63...

Advocates for Women's Sports Say 1988 Civil-Rights Act Has Not Brought Hoped-for Equity with Men.

ERIC Educational Resources Information Center

Oberlander, Susan

1989-01-01

The passage of the Civil Rights Restoration Act of 1988 was seen by advocates of women's sports as a powerful tool to redress sex imbalances in college sports programs, but few sex discrimination complaints have been filed as a result. The reasons are disputed and not fully understood. (MSE)

Migration of fallout radiocaesium in a grassland soil from 1986 to 2001. Part I: activity-depth profiles of (134)Cs and (137)Cs.

PubMed

Schimmack, W; Schultz, W

2006-09-15

The temporal changes of the vertical distribution of (134)Cs (deposited by the Chernobyl fallout in 1986) and (137)Cs (deposited by the Chernobyl and the global fallout) in the soil were investigated at an undisturbed Bavarian grassland site in Germany. At ten sampling dates between 1986 and 2001, the activity density of (134)Cs and (137)Cs was determined in various soil layers down to 80 cm depth. In 2001, the small-scale spatial variability of the radiocaesium activity was determined by sampling five plots within 10 m(2) (coefficient of variation about 20% for the upper soil layers). Between 1987 and 1990, substantial changes of the activity-depth profiles were observed. The percentage depth distributions of (134)Cs and (137)Cs were rather similar. The 50%-depth of the accumulated activity increased from 2.4 cm in 1988 to 5.3 cm in 2001 for (134)Cs and from 2.7 to 5.8 cm for (137)Cs. This indicates that at the study site the migration data of Chernobyl-derived (137)Cs can be estimated by those of total (137)Cs. In the second part of this study, the activity-depth profiles will be evaluated by the convection-dispersion model [Schimmack, W, Feria Márquez, F. Migration of fallout radiocaesium in a grassland soil from 1986 to 2001. Part II: Evaluation of the activity-depth profiles by transport models. Sci Total Environ 2006-this issue].

Survival of Older Patients With Cancer in the Veterans Health Administration Versus Fee-for-Service Medicare

PubMed Central

Landrum, Mary Beth; Keating, Nancy L.; Lamont, Elizabeth B.; Bozeman, Samuel R.; Krasnow, Steven H.; Shulman, Lawrence; Brown, Jennifer R.; Earle, Craig C.; Rabin, Michael; McNeil, Barbara J.

2012-01-01

Purpose The Veterans Health Administration (VHA) provides high-quality preventive chronic care and cancer care, but few studies have documented improved patient outcomes that result from this high-quality care. We compared the survival rates of older patients with cancer in the VHA and fee-for-service (FFS) Medicare and examined whether differences in the stage at diagnosis, receipt of guideline-recommended therapies, and unmeasured characteristics explain survival differences. Patients and Methods We used propensity-score methods to compare all-cause and cancer-specific survival rates for men older than age 65 years who were diagnosed or received their first course of treatment for colorectal, lung, lymphoma, or multiple myeloma in VHA hospitals from 2001 to 2004 to similar FFS-Medicare enrollees diagnosed in Surveillance, Epidemiology, and End Results (SEER) areas in the same time frame. We examined the role of unmeasured factors by using sensitivity analyses. Results VHA patients versus similar FFS SEER-Medicare patients had higher survival rates of colon cancer (adjusted hazard ratio [HR], 0.87; 95% CI, 0.82 to 0.93) and non–small-cell lung cancer (NSCLC; HR, 0.91; 95% CI, 0.88 to 0.95) and similar survival rates of rectal cancer (HR, 1.05; 95% CI, 0.95 to 1.16), small-cell lung cancer (HR, 0.99; 95% CI, 0.93 to 1.05), diffuse large–B-cell lymphoma (HR, 1.02; 95% CI, 0.89 to 1.18), and multiple myeloma (HR, 0.92; 95% CI, 0.83 to 1.03). The diagnosis of VHA patients at earlier stages explained much of the survival advantages for colon cancer and NSCLC. Sensitivity analyses suggested that additional adjustment for the severity of comorbid disease or performance status could have substantial effects on estimated differences. Conclusion The survival rate for older men with cancer in the VHA was better than or equivalent to the survival rate for similar FFS-Medicare beneficiaries. The VHA provision of high-quality care, particularly preventive care, can result in improved patient outcomes. PMID:22393093

Survival of older patients with cancer in the Veterans Health Administration versus fee-for-service Medicare.

PubMed

Landrum, Mary Beth; Keating, Nancy L; Lamont, Elizabeth B; Bozeman, Samuel R; Krasnow, Steven H; Shulman, Lawrence; Brown, Jennifer R; Earle, Craig C; Rabin, Michael; McNeil, Barbara J

2012-04-01

The Veterans Health Administration (VHA) provides high-quality preventive chronic care and cancer care, but few studies have documented improved patient outcomes that result from this high-quality care. We compared the survival rates of older patients with cancer in the VHA and fee-for-service (FFS) Medicare and examined whether differences in the stage at diagnosis, receipt of guideline-recommended therapies, and unmeasured characteristics explain survival differences. We used propensity-score methods to compare all-cause and cancer-specific survival rates for men older than age 65 years who were diagnosed or received their first course of treatment for colorectal, lung, lymphoma, or multiple myeloma in VHA hospitals from 2001 to 2004 to similar FFS-Medicare enrollees diagnosed in Surveillance, Epidemiology, and End Results (SEER) areas in the same time frame. We examined the role of unmeasured factors by using sensitivity analyses. VHA patients versus similar FFS SEER-Medicare patients had higher survival rates of colon cancer (adjusted hazard ratio [HR], 0.87; 95% CI, 0.82 to 0.93) and non-small-cell lung cancer (NSCLC; HR, 0.91; 95% CI, 0.88 to 0.95) and similar survival rates of rectal cancer (HR, 1.05; 95% CI, 0.95 to 1.16), small-cell lung cancer (HR, 0.99; 95% CI, 0.93 to 1.05), diffuse large-B-cell lymphoma (HR, 1.02; 95% CI, 0.89 to 1.18), and multiple myeloma (HR, 0.92; 95% CI, 0.83 to 1.03). The diagnosis of VHA patients at earlier stages explained much of the survival advantages for colon cancer and NSCLC. Sensitivity analyses suggested that additional adjustment for the severity of comorbid disease or performance status could have substantial effects on estimated differences. The survival rate for older men with cancer in the VHA was better than or equivalent to the survival rate for similar FFS-Medicare beneficiaries. The VHA provision of high-quality care, particularly preventive care, can result in improved patient outcomes.

Dynamic Estimation on Output Elasticity of Highway Capital Stock in China

NASA Astrophysics Data System (ADS)

Li, W. J.; Zuo, Q. L.; Bai, Y. F.

2017-12-01

By using the Perpetual Inventory Method to calculate the capital stock of highway in China from 1988 to 2016, the paper builds the State Space Model based on Translog Production Function, according to the Ridge Regression and Kalman Filter Method, the dynamic estimation results of output elasticity are measured continuously and analyzed. The conclusions show that: Firstly, China’s growth speed on highway industry capital stock are divided into three stages which are respectively from 1988 to 2000, from 2001 to 2009 and from 2010 to 2016, during which shows steady growth, between which reflect rapid growth; Secondly, the output elasticity of highway capital stock, being between 0.154 and 0.248, is slightly larger than the output elasticity of human input factor, lower than the output elasticity of the technical level, shows positive effect on transport economy and rises steadily, but the output efficiency is low on the whole; Thirdly, around the year of 2010, the scale pay on highway industry begins to highlight the characteristic of increase.

49 CFR Appendix A to Part 593 - List of Vehicles Determined To Be Eligible for Importation

Code of Federal Regulations, 2012 CFR

2012-10-01

... Vantage 2006-2007 530 Audi 80 1988-1989 223 Audi 100 1989 93 Audi 100 1993 244 Audi 100 1990-1992 317 Audi A4 1996-2000 352 Audi A4, RS4, S4 8D 2000-2001 400 Audi A6 1998-1999 332 Audi A8 2000 424 Audi A8 1997-2000 337 Audi A8 Avant Quattro 1996 238 Audi RS6 & RS Avant 2003 443 Audi S6 1996 428 Audi S8 2000...

Electro-Optic Identification (EOID) Research Program

DTIC Science & Technology

2001-09-30

1 Electro - Optic Identification (EOID) Research Program Gene M. Cumm Northrop Grumman Oceanic and Naval Systems P.O. Box 1488 Annapolis...control number. 1. REPORT DATE 30 SEP 2001 2. REPORT TYPE 3. DATES COVERED 00-00-2001 to 00-00-2001 4. TITLE AND SUBTITLE Electro - Optic Identification

Cardiovascular disease is the leading cause of death among endometrial cancer patients.

PubMed

Ward, Kristy K; Shah, Nina R; Saenz, Cheryl C; McHale, Michael T; Alvarez, Edwin A; Plaxe, Steven C

2012-08-01

To evaluate the causes of death among women with endometrial cancer. SEER registries from 1973-1988 were queried to perform a retrospective cohort study of women with invasive epithelial endometrial cancer. Causes of death were compared according to grade and stage. 33,232 women with incident cases of endometrial cancer had died at the time of last follow up. Overall, women were most likely to die from cardiovascular disease (35.9%, 95% CI 35.3-36.3%), followed by other causes, other malignancies, and endometrial cancer. Women with low grade localized cancer were most likely to die of cardiovascular disease, while women with high grade advanced cancer were least likely to die of cardiovascular disease and most likely to die of endometrial cancer. For the entire population, risk of death from cardiovascular causes surpasses the risk of death from endometrial cancer 5 years after diagnosis. Higher risk of cardiac death among endometrial cancer patients likely reflects the high probability of curative cancer treatment and the prevalence of cardiac disease and risk factors. As the probability of dying of endometrial cancer decreases with time, the probability of dying of cardiovascular disease increases. Interventions and investigations aimed at addressing risk factors for cardiovascular disease may have the greatest potential to improve survival for women diagnosed with endometrial cancer and should feature prominently in treatment and survivorship plans. Copyright © 2012 Elsevier Inc. All rights reserved.

National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program 1988, volume 1

NASA Technical Reports Server (NTRS)

Bannerot, Richard B. (Editor); Goldstein, Stanley H. (Editor)

1989-01-01

The 1988 Johnson Space Center (JSC) National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program was conducted by the University of Houston and JSC. The 10-week program was operated under the auspices of the ASEE. The program at JSC, as well as the programs at other NASA Centers, was funded by the Office of University Affairs, NASA Headquarters, Washington, D.C. The objectives of the program, which began in 1965 at JSC and in 1964 nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of participants' institutions; and (4) to contribute to the research objectives of the NASA Centers.

National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program 1988, volume 2

NASA Technical Reports Server (NTRS)

Bannerot, Richard B.; Goldstein, Stanley H.

1989-01-01

The 1988 Johnson Space Center (JSC) National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program was conducted by the University of Houston and JCS. The 10-week program was operated under the auspices of the ASEE. The program at JSC, as well as the programs at other NASA Centers, was funded by the Office of University Affairs, NASA Headquarters, Washington, D.C. The objectives of the program, which began in 1965 at JSC and in 1964 nationally, are: (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of participants' institutions; and (4) to contribute to the research objectives of the NASA Centers.

Fiscal year 1988 program report: Pennsylvania Center for Water Resources Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonnell, A.J.

1989-08-01

Three projects and a program of technology transfer were conducted under the Pennsylvania Fiscal Year 1988 State Water Resources Research Grants Program (PL 98-242, Sect. 104). In a completed study focused on the protection of water supplies, mature slow sand filters were found to remove 100 percent of Cryptosporidium and Giardia cysts. A site specific study examined the behavior of sedimentary iron and manganese in an acid mine drainage wetland system. A study was initiated to link a comprehensive non-point source model, AGNPS with current GIS technology to enhance the models' utility for evaluating regional water quality problems related tomore » non-point source agricultural pollution.« less

The contribution of education, social class and economic activity to the income-mortality association in alcohol-related and other mortality in Finland in 1988-2012.

PubMed

Tarkiainen, Lasse; Martikainen, Pekka; Laaksonen, Mikko

2016-03-01

First, to quantify trends in the contribution of alcohol-related mortality to mortality disparity in Finland by income quintiles. Secondly, to estimate the degree to which education, social class and economic activity explain the income-mortality association in alcohol-related and other mortality in four periods within 1988-2012. Register-based longitudinal study using an 11% random sample of Finnish residents linked to socio-economic and mortality data in 1988-2012 augmented with an 80% sample of all deaths during 1988-2007. Mortality rates and discrete time survival regression models were used to assess the income-mortality association following adjustment for covariates in 6-year periods after baseline years of 1988, 1994, 2001, and 2007. Finland. Individuals aged 35-64 years at baselines. For the four study periods for men/women, the final data set comprised, respectively, 26,360/12,825, 22,561/11,423, 20,342/11,319 and 2651/1514 deaths attributable to other causes and 7517/1217, 8199/1450, 9807/2116, 1431/318 deaths attributable to alcohol-related causes. Alcohol-related deaths were analysed with household income, education, social class and economic activity as covariates. The income disparity in mortality originated increasingly from alcohol-related causes of death, in the lowest quintile the contribution increasing from 28 to 49% among men and from 11 to 28% among women between periods 1988-93 and 2007-12. Among men, socio-economic characteristics attenuated the excess mortality during each study period in the lowest income quintile by 51-62% in alcohol-related and other causes. Among women, in the lowest quintile the attenuation was 47-76% in other causes, but there was a decreasing tendency in the proportion explained by the covariates in alcohol-related mortality. The income disparity in mortality among working-age Finns originates increasingly from alcohol-related causes of death. Roughly half the excess mortality in the lowest income quintile during 2007-12 is explained by the covariates of household income, education, social class and economic activity. © 2015 Society for the Study of Addiction.

Update on the National Vaccine Injury Compensation Program.

PubMed

Edlich, Richard F; Olson, Dana M; Olson, Brianna M; Greene, Jill Amanda; Gubler, K Dean; Winters, Kathryne L; Kelley, Angela R; Britt, L D; Long, William B

2007-08-01

The National Childhood Vaccine Injury Act of 1986, as amended, established the Vaccine Injury Compensation Program (VICP). The VICP went into effect on October 1, 1988 and is a Federal "no-fault" system designed to compensate individuals, or families of individuals, who have been injured by covered vaccines. From 1988 until July 2006, a total of 2531 non-autism/thimerosal and 5030 autism/thimerosal claims were made to the VICP. The compensation paid for the non-autism/thimerosal claims from 1988 until 2006 was $902,519,103.37 for 2542 awards. There was no compensation for any of the autism/thimerosal claims. On the basis of the deaths and extensive suffering to patients and families from the adverse reactions to vaccines, all physicians must provide detailed information in the Vaccine Information Statement to the patient or the parent or legal guardian of the child about the potential dangers of vaccines as well as the VICP.

Installation Restoration Program. Remedial Investigation Report. Minnesota Air National Guard Base Duluth International Airport, Duluth, Minnesota. Volume 5

DTIC Science & Technology

1990-01-01

1-20 1-6 Sites Defined and Ranked During IRP Phase I Study. 1-29 1-7 Aerial Photograph of Site 2, April 1988. 1-32 1-8 Site 2 Sampling Locations...Utilized During Phase II Investigations. 1-35 1-9 Aerial Photograph of Site 3, April 1988. 1-38 1-10 Site 3 Sampling Locations Utilized During Phase II...Investigations. 1-47 1-11 Aerial Photograph of Site 4, April 1988. 1-54 1-12 Site 4 Sampling Locations Utilized During Phase II Investigations. 1-57 1-13

Asian-American Communications In-School Staff and Parent Workshops 1988-89. OREA Evaluation Section Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Gritzer, Glenn

This report presents an evaluation of the Asian-American Communications (A-AC) In-School Staff and Parent Workshops program in New York City public schools for the 1988-89 school year. A-AC provided workshops on Asian cultures for schools with large Asian populations and acted as a resource center by offering support services to interested…

75 FR 30839 - Privacy Act of 1974; CMS Computer Match No. 2010-03, HHS Computer Match No. 1003, SSA Computer...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-02

... of the Matching Program A. General The Computer Matching and Privacy Protection Act of 1988 (Pub. L.... 100-503, the Computer Matching and Privacy Protection Act (CMPPA) of 1988), the Office of Management... 1974; CMS Computer Match No. 2010-03, HHS Computer Match No. 1003, SSA Computer Match No. 1048, IRS...

Northeast Artificial Intelligence Consortium Annual Report - 1988 Parallel Vision. Volume 9

DTIC Science & Technology

1989-10-01

supports the Northeast Aritificial Intelligence Consortium (NAIC). Volume 9 Parallel Vision Report submitted by Christopher M. Brown Randal C. Nelson...NORTHEAST ARTIFICIAL INTELLIGENCE CONSORTIUM ANNUAL REPORT - 1988 Parallel Vision Syracuse University Christopher M. Brown and Randal C. Nelson...Technical Director Directorate of Intelligence & Reconnaissance FOR THE COMMANDER: IGOR G. PLONISCH Directorate of Plans & Programs If your address has

Health Lifestyle Analysis of Faculty Staff and Employees at the University of Montevallo in 1982 to 1988.

ERIC Educational Resources Information Center

Tishler, J. Ward

Changes were studied in the health lifestyle of university personnel involved in a program of health promotion and wellness between 1982 and 1988. Data were collected via a survey at the University of Montevallo in Alabama. Questions were asked on personal characteristics (e.g. gender, age, height, and marital status), professional characteristics…

40 CFR 147.2651 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Puerto Rico... on Indian lands in the Commonwealth of Puerto Rico is administered by EPA. This program consists of... Commonwealth of Puerto Rico is November 25, 1988. [57 FR 33446, July 29, 1992] ...

40 CFR 147.2651 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Puerto Rico... on Indian lands in the Commonwealth of Puerto Rico is administered by EPA. This program consists of... Commonwealth of Puerto Rico is November 25, 1988. [57 FR 33446, July 29, 1992] ...

40 CFR 147.2651 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2013 CFR

2013-07-01

... PROGRAMS (CONTINUED) STATE, TRIBAL, AND EPA-ADMINISTERED UNDERGROUND INJECTION CONTROL PROGRAMS Puerto Rico... on Indian lands in the Commonwealth of Puerto Rico is administered by EPA. This program consists of... Commonwealth of Puerto Rico is November 25, 1988. [57 FR 33446, July 29, 1992] ...

Temporal variations of water quality and the taxonomic structures of phytoplankton and zooplankton assemblages in mountain lakes, Mount Rainier National Park, Washington USA

USGS Publications Warehouse

Larson, Gary L.; McIntire, C.D.; Jacobs, Ruth W.; Truitt, R.

1999-01-01

A synoptic inventory of physical and chemical properties and plankton assemblages of 27 mountain lakes was conducted at Mount Rainier National Park in 1988. From 1990–1993, die opportunity was presented to resurvey six of these lakes to determine inter-annual change within die set of characteristics surveyed in 1988. If changes were evident, a second objective was to provide guidance to park management about the value of a long-term lake monitoring program.Secchi-disk clarity, water temperature, and pH of the lakes in 1988 were within the range of values obtained between 1990 and 1993. Conductivities and concentration of nutrients in some lakes were not consistent in 1990–1993 with the values recorded in 1988. Although the dominant phytoplankton taxa in die lakes varied among years, die taxa in individual lakes were in consistent among years, with die exception of two lakes. Rotifer assemblages were consistent among years, but most of die lakes exhibited dramatic changes in some years, as did crustacean zooplankton assemblages. Suggestions were made about die need for a long-term monitoring program to evaluate die status and trends of park lakes.

Royal Decree No. 727/1988 on the restructuring of ministerial departments, 11 July 1988.

PubMed

1988-01-01

This Decree restructures the Central Administration of Spain to include the Ministry of Social Affairs. Among the functions of the Ministry are the following: 1) the preparation and execution of the Government's policy for the promotion and encouragement of conditions that make possible the social equality of both sexes, and the participation of women in political, cultural, economic, and social life; and 2) the legal protection of minors and, in a general fashion, the analysis, formulation, and coordination of programs of action relating to the prevention of juvenile delinquency; the promotion of institutions for adoption and foster care; and the evaluation and inspection of organizations of family integration. Royal Decree No. 791/1988 of the Ministry of Social Affairs of 20 July 1988 sets forth the organic structure of the Ministry of Social Affairs. Among the departments of the Ministry is the General Directorate for the Protection of Minors, whose general objective is the analysis, formulation, coordination, and supervision of programs of action relating to the legal and social protection of minors and the prevention of the marginalization of infants and youth. Attached to the Ministry as an autonomous organization is the Women's Institute. full text

Programs Offered and Programs Completed at North Dakota Institutions of Postsecondary Education, July 1, 2001-June 30, 2002.

ERIC Educational Resources Information Center

North Dakota Univ. System, Bismarck.

This report provides information on degree and certificate programs offered and student program completions for fiscal year 2001-2002 in North Dakota's public and private postsecondary education institutions. Institutional programs are coded in accordance with the Classification of Instructional Programs (CIP Code) system provided by the National…

Programs Offered and Programs Completed at North Dakota Institutions of Postsecondary Education, July 1, 2000-June 30, 2001.

ERIC Educational Resources Information Center

North Dakota Univ. System, Bismarck.

This report provides information on degree and certificate programs offered and student program completions for fiscal year 2000-2001 in North Dakota's public and private postsecondary educational institutions. Institutions programs are coded in accordance with the Classification of Instructional Programs (CIP) code system of the National Center…

N0/N1, PNL, or LNR? The effect of lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma.

PubMed

Valsangkar, Nakul P; Bush, Devon M; Michaelson, James S; Ferrone, Cristina R; Wargo, Jennifer A; Lillemoe, Keith D; Fernández-del Castillo, Carlos; Warshaw, Andrew L; Thayer, Sarah P

2013-02-01

We evaluated the prognostic accuracy of LN variables (N0/N1), numbers of positive lymph nodes (PLN), and lymph node ratio (LNR) in the context of the total number of examined lymph nodes (ELN). Patients from SEER and a single institution (MGH) were reviewed and survival analyses performed in subgroups based on numbers of ELN to calculate excess risk of death (hazard ratio, HR). In SEER and MGH, higher numbers of ELN improved the overall survival for N0 patients. The prognostic significance (N0/N1) and PLN were too variable as the importance of a single PLN depended on the total number of LN dissected. LNR consistently correlated with survival once a certain number of lymph nodes were dissected (≥13 in SEER and ≥17 in the MGH dataset). Better survival for N0 patients with increasing ELN likely represents improved staging. PLN have some predictive value but the ELN strongly influence their impact on survival, suggesting the need for a ratio-based classification. LNR strongly correlates with outcome provided that a certain number of lymph nodes is evaluated, suggesting that the prognostic accuracy of any LN variable depends on the total number of ELN.

Annual environmental monitoring report of the Lawrence Berkeley Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schleimer, G.E.

1989-06-01

The Environmental Monitoring Program of the Lawrence Berkeley Laboratory (LBL) is described. Data for 1988 are presented and general trends are discussed. In order to establish whether LBL research activities produced any impact on the population surrounding the laboratory, a program of environmental air and water sampling and continuous radiation monitoring was carried on throughout the year. For 1988, as in the previous several years, dose equivalents attributable to LBL radiological operations were a small fraction of both the relevant radiation protection guidelines (RPG) and of the natural radiation background. 16 refs., 7 figs., 21 tabs.

The 1988-1989 NASA Space/Gravitational Biology Accomplishments

NASA Technical Reports Server (NTRS)

Halstead, Thora W. (Editor)

1990-01-01

This report consists of individual technical summaries of research projects of NASA's space/gravitational biology program, for research conducted during the period May 1988 to April 1989. This program is concerned with using the unique characteristics of the space environment, particularly microgravity, as a tool to advance knowledge in the biological sciences; understanding how gravity has shaped and affected life on Earth; and understanding how the space environment affects both plant and animal species. The summaries for each project include a description of the research, a list of the accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

The 1987-1988 NASA space/gravitational biology accomplishments

NASA Technical Reports Server (NTRS)

Halstead, Thora W. (Editor)

1988-01-01

Individual technical summaries of research projects of the NASA Space/Gravitational Biology Program, for research conducted during the period January 1987 to April 1988 are presented. This Program is concerned with using the characteristics of the space environment, particularly microgravity, as a tool to advance knowledge in the biological sciences; understanding how gravity has shaped and affected life on earth; and understanding how the space environment affects both plant and animal species. The summaries for each project include a description of the research, a list of the accomplishments, an explanation of the significance of the accomplishments, and a list of publications.

International Congress of Psychology (24) on the 1988 Travel Awards Program Conducted by the American Psychological Association on Behalf of the US National Committee for the International Union of Psychological Science Held in Sydney, Australia on 28 August-2 September 1988

DTIC Science & Technology

1989-01-18

ORGANZAT:ON 6o OFFfCE SYMBOL 7a NAME OF MONITORING ORGANZATON American Psychological Assoc. (Ifapplicable) Office of Naval Research 6c. ADDRESS (City, State...8a. NAME OF FUNDING, SPONSORING 8b OFFICE SYMBOL 9 PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION (If applicable) Office of Naval Research...from different countries. The other components of the program were Invited and Keynote Page 6 addresses, Individual papers, and workshops on both

Mortality Risk from Co-Morbidities independent of Triple-Negative Breast Cancer Status: NCI SEER-based Cohort Analysis

PubMed Central

Swede, Helen; Sarwar, Amna; Magge, Anil; Braithwaite, Dejana; Cook, Linda S.; Gregorio, David I.; Jones, Beth A; Hoag, Jessica; Gonsalves, Lou; Salner, Andrew; Zarfos, Kristen; Andemariam, Biree; Stevens, Richard G; Dugan, Alicia; Pensa, Mellisa; Brockmeyer, Jessica

2017-01-01

Purpose A comparatively high prevalence of co-morbidities among African-American/Blacks (AA/B) has been implicated in disparate survival in breast cancer. There is a scarcity of data, however, if this effect persists when accounting for the adverse triple-negative breast cancer (TNBC) subtype which occurs at three-fold the rate in AA/B compared to white breast cancer patients. Methods We reviewed charts of 214 white and 202 AA/B breast cancer patients in the NCI-SEER Connecticut Tumor Registry who were diagnosed in 2000-07. We employed the Charlson Co-Morbidity Index (CCI), a weighted 17-item tool to predict risk of death in cancer populations. Cox Survival Analyses estimated hazard ratios (HR) for all-cause mortality in relation to TNBC and CCI adjusting for clinicopathological factors. Results Among patients with SEER-Local Stage, TNBC increased the risk of death (HR=2.18, 95% CI 1.14-4.16), which was attenuated when the CCI score was added to the model (Adj. HR=1.50, 95% CI 0.74-3.01). Conversely, the adverse impact of the CCI score persisted when controlling for TNBC (Adj. HR=1.49, 95% CI 1.29-1.71; per one point increase). Similar patterns were observed in SEER-Regional Stage but estimated HRs were lower. AA/B patients with a CCI score of ≥3 had a significantly higher risk of death compared to AA/B patients without comorbidities (Adj. HR=5.65, 95% CI 2.90-11.02). A lower and non-significant effect was observed for whites with a CCI of ≥3 (Adj. HR=1.90, 95% CI 0.68-5.29). Conclusions Co-morbidities at diagnosis increase risk of death independent of TNBC, and AA/B patients may be disproportionately at risk. PMID:27000206

Breast cancer-specific survival in patients with lymph node-positive hormone receptor-positive invasive breast cancer and Oncotype DX Recurrence Score results in the SEER database.

PubMed

Roberts, Megan C; Miller, Dave P; Shak, Steven; Petkov, Valentina I

2017-06-01

The Oncotype DX ® Breast Recurrence Score™ (RS) assay is validated to predict breast cancer (BC) recurrence and adjuvant chemotherapy benefit in select patients with lymph node-positive (LN+), hormone receptor-positive (HR+), HER2-negative BC. We assessed 5-year BC-specific survival (BCSS) in LN+ patients with RS results in SEER databases. In this population-based study, BC cases in SEER registries (diagnosed 2004-2013) were linked to RS results from assays performed by Genomic Health (2004-2014). The primary analysis included only patients (diagnosed 2004-2012) with LN+ (including micrometastases), HR+ (per SEER), and HER2-negative (per RT-PCR) primary invasive BC (N = 6768). BCSS, assessed by RS category and number of positive lymph nodes, was calculated using the actuarial method. The proportion of patients with RS results and LN+ disease (N = 8782) increased over time between 2004 and 2013, and decreased with increasing lymph node involvement from micrometastases to ≥4 lymph nodes. Five-year BCSS outcomes for those with RS < 18 ranged from 98.9% (95% CI 97.4-99.6) for those with micrometastases to 92.8% (95% CI 73.4-98.2) for those with ≥4 lymph nodes. Similar patterns were found for patients with RS 18-30 and RS ≥ 31. RS group was strongly predictive of BCSS among patients with micrometastases or up to three positive lymph nodes (p < 0.001). Overall, 5-year BCSS is excellent for patients with RS < 18 and micrometastases, one or two positive lymph nodes, and worsens with additionally involved lymph nodes. Further analyses should account for treatment variables, and longitudinal updates will be important to better characterize utilization of Oncotype DX testing and long-term survival outcomes.

Infants and Toddlers, 2001-2002.

ERIC Educational Resources Information Center

Kroenke, Lillian DeVault, Ed.

2002-01-01

This document is comprised of the 2001-2002 issues of a quarterly journal for teachers and parents of children in Montessori infant and toddler programs. The spring 2001 issue presents articles on the history of infant and toddler programs in Italy and how to fulfill infant needs in Montessori child care, and on learning activities in the kitchen…

Modern & Classical Languages: K-12 Program EValuation 1988-89.

ERIC Educational Resources Information Center

Martinez, Margaret Perea

This evaluation of the modern and classical languages programs, K-12, in the Albuquerque (New Mexico) public school system provides general information on the program's history, philosophy, recognition, curriculum development, teachers, and activities. Specific information is offered on the different program components, namely, the elementary…

Annual Report to Congress: Federal Alternative Motor Fuels Programs (4th : 1995)

DOT National Transportation Integrated Search

1995-07-01

This annual report to Congress presents the current status of the alternative : fuel programs being conducted across the country in accordance to the : Alternative Motor Fuels Act of 1988. These programs, which represent the most : comprehensive data...

How meaning similarity influences ambiguous word processing: the current state of the literature

PubMed Central

Tokowicz, Natasha

2016-01-01

The majority of words in the English language do not correspond to a single meaning, but rather correspond to two or more unrelated meanings (i.e., are homonyms) or multiple related senses (i.e., are polysemes). It has been proposed that the different types of “semantically-ambiguous words” (i.e., words with more than one meaning) are processed and represented differently in the human mind. Several review papers and books have been written on the subject of semantic ambiguity (e.g., Adriaens, Small, Cottrell, & Tanenhaus, 1988; Burgess & Simpson, 1988; Degani & Tokowicz, 2010; Gorfein, 1989, 2001; Simpson, 1984). However, several more recent studies (e.g., Klein & Murphy, 2001; Klepousniotou, 2002; Klepousniotou & Baum, 2007; Rodd, Gaskell, & Marslen-Wilson, 2002) have investigated the role of the semantic similarity between the multiple meanings of ambiguous words on processing and representation, whereas this was not the emphasis of previous reviews of the literature. In this review, we focus on the current state of the semantic ambiguity literature that examines how different types of ambiguous words influence processing and representation. We analyze the consistent and inconsistent findings reported in the literature and how factors such as semantic similarity, meaning/sense frequency, task, timing, and modality affect ambiguous word processing. We discuss the findings with respect to recent parallel distributed processing (PDP) models of ambiguity processing (Armstrong & Plaut, 2008, 2011; Rodd, Gaskell, & Marslen-Wilson, 2004). Finally, we discuss how experience/instance-based models (e.g., Hintzman, 1986; Reichle & Perfetti, 2003) can inform a comprehensive understanding of semantic ambiguity resolution. PMID:24889119

Nuclear Test-Experimental Science: Annual report, fiscal year 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Struble, G.L.; Donohue, M.L.; Bucciarelli, G.

1988-01-01

Fiscal year 1988 has been a significant, rewarding, and exciting period for Lawrence Livermore National Laboratory's nuclear testing program. It was significant in that the Laboratory's new director chose to focus strongly on the program's activities and to commit to a revitalized emphasis on testing and the experimental science that underlies it. It was rewarding in that revolutionary new measurement techniques were fielded on recent important and highly complicated underground nuclear tests with truly incredible results. And it was exciting in that the sophisticated and fundamental problems of weapons science that are now being addressed experimentally are yielding new challengesmore » and understanding in ways that stimulate and reward the brightest and best of scientists. During FY88 the program was reorganized to emphasize our commitment to experimental science. The name of the program was changed to reflect this commitment, becoming the Nuclear Test-Experimental Science (NTES) Program.« less

Honolulu Community College Program Health Indicators: 2000-2001 Program Reviews.

ERIC Educational Resources Information Center

Hawaii Univ., Honolulu. Honolulu Community Coll.

This report presents an overall health summation of 21 programs offered at Honolulu Community College (Hawaii) during 2000-2001. The programs profiled are: (1) Auto Body Repair and Painting; (2) Aeronautics Maintenance Technology; (3) Administration of Justice; (4) Automotive Mechanics Technology; (5) Boat Maintenance Repair; (6) Carpentry; (7)…

SEER Cancer Stat Facts

Cancer.gov

These summaries provide statistics for common cancer types. The statistics include incidence, mortality, survival, stage, prevalence, and lifetime risk. Links to additional resources are included. Updated annually.

Advanced engineering design program at the University of Illinois for the 1987-1988 academic year

NASA Technical Reports Server (NTRS)

Sivier, Kenneth R.; Lembeck, Michael F.

1988-01-01

The participation of the University of Illinois at Urbana-Champaign in the NASA/USRA Universities Advanced Engineering Design Program (Space) is reviewed for the 1987 to 88 academic year. The University's design project was the Manned Marsplane and Delivery System. In the spring of 1988 semester, 107 students were enrolled in the Aeronautical and Astronautical Engineering Departments' undergraduate Aerospace Vehicle Design course. These students were divided into an aircraft section (responsible for the Marsplane design), and a spacecraft section (responsible for the Delivery System Design). The design results are presented in Final Design Reports, copies of which are attached. In addition, five students presented a summary of the design results at the Program's Summer Conference.

NAS Panel endorses science center concept

NASA Astrophysics Data System (ADS)

Science and technology centers, as proposed by President Ronald Reagan in his January 1987 State of the Union message, could make “significant contributions to science and to the nation's economic competitiveness,” according to a new report by a National Academy of Sciences (NAS) panel. What will be necessary to realize these contributions, the panel cautioned, are proper management, adequate resources, and, “above all, the selection of programs for which the centers are the most effective form of organization.”NSF plans to support science and technology centers, beginning October 1, 1988, which is the start of fiscal year 1988. NSF requested guidance from the NAS panel in implementing the program. Although other government agencies will participate in the program, NSF will play the primary role.

Could gender equality in parental leave harm off-springs' mental health? a registry study of the Swedish parental/child cohort of 1988/89

PubMed Central

2012-01-01

Introduction Mental ill-health among children and young adults is a growing public health problem and research into causes involves consideration of family life and gender practice. This study aimed at exploring the association between parents' degree of gender equality in childcare and children's mental ill-health. Methods The population consisted of Swedish parents and their firstborn child in 1988-1989 (N = 118 595 family units) and the statistical method was multiple logistic regression. Gender equality of childcare was indicated by the division of parental leave (1988-1990), and child mental ill-health was indicated by outpatient mental care (2001-2006) and drug prescription (2005-2008), for anxiety and depression. Results The overall finding was that boys with gender traditional parents (mother dominance in childcare) have lower risk of depression measured by outpatient mental care than boys with gender-equal parents, while girls with gender traditional and gender untraditional parents (father dominance in childcare) have lower risk of anxiety measured by drug prescription than girls with gender-equal parents. Conclusions This study suggests that unequal parenting regarding early childcare, whether traditional or untraditional, is more beneficial for offspring's mental health than equal parenting. However, further research is required to confirm our findings and to explore the pathways through which increased gender equality may influence child health. PMID:22463683

Could gender equality in parental leave harm off-springs' mental health? A registry study of the Swedish parental/child cohort of 1988/89.

PubMed

Norström, Lisa; Lindberg, Lene; Månsdotter, Anna

2012-03-30

Mental ill-health among children and young adults is a growing public health problem and research into causes involves consideration of family life and gender practice. This study aimed at exploring the association between parents' degree of gender equality in childcare and children's mental ill-health. The population consisted of Swedish parents and their firstborn child in 1988-1989 (N = 118 595 family units) and the statistical method was multiple logistic regression. Gender equality of childcare was indicated by the division of parental leave (1988-1990), and child mental ill-health was indicated by outpatient mental care (2001-2006) and drug prescription (2005-2008), for anxiety and depression. The overall finding was that boys with gender traditional parents (mother dominance in childcare) have lower risk of depression measured by outpatient mental care than boys with gender-equal parents, while girls with gender traditional and gender untraditional parents (father dominance in childcare) have lower risk of anxiety measured by drug prescription than girls with gender-equal parents. This study suggests that unequal parenting regarding early childcare, whether traditional or untraditional, is more beneficial for offspring's mental health than equal parenting. However, further research is required to confirm our findings and to explore the pathways through which increased gender equality may influence child health.

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM ANNUAL REPORT TO CONGRESS FY 2001

EPA Science Inventory

This report details the fiscal year 2001 activities of the Superfund Innovative Technology Evaluation (SITE) Program. The Program focuses on the remediation needs of the hazardous waste remediation community through demonstration and evaluation of innovative technologies for re...

40 CFR 272.201 - Arkansas State-administered program: Final authorization.

Code of Federal Regulations, 2010 CFR

2010-07-01

... September 1, 1988 (53 FR 33938) and the July 1, 1991 (56 FR 30200) amendments to Parts 264 and 265..., chapter 2, sections 3a(5) and 3a(6) adopting the September 1, 1988 and the July 1, 1991 amendments are not..., Little Rock, AR 72219-8913, Phone: (501) 682-0923. You may inspect a copy at EPA Region 6, 1445 Ross...

40 CFR 272.951 - Louisiana State-administered program: Final authorization.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., 1997. Copies of the document can be obtained from EPA Region 6, 1445 Ross Avenue, Dallas, Texas 75202... November 20, 1988 LR 18:1375 December 20, 1992. LAC § 303.K.1 (previously LHWR § 3.2(k)(1)) July 20, 1984 LR 14:790 November 20, 1988. LAC § 901 (LHWR § 6.1) March 20, 1984 LR 20:1000 September 20, 1994. LAC...

Statistical Supplement to the Annual Status Report on Texas Community Junior Colleges and Technical Institutes, 1989. Fiscal Year 1989, September 1, 1988-August 31, 1989.

ERIC Educational Resources Information Center

Texas Higher Education Coordinating Board, Austin.

This statistical supplement contains information on student enrollments, faculty, semester credit hours, physical facilities, appropriations, and student loan and grant programs for Texas community junior colleges and technical institutes. The enrollment section provides a 5-year summary of headcount enrollments for 1984 to 1988 for all segments…

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

30 CFR 915.15 - Approval of Iowa regulatory program amendments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Bill. August 12, 1986 December 11, 1986 IAC 4.522(15)c, g. April 28, 1987 October 7, 1987 I.C. 83.7. June 9, 1988. December 9, 1988 I.C. 83.26. December 26, 1990 November 6, 1991 IAC 27-40.1 through .7, .11, .12, .13, .21, .22, .23, .30 through .39, .41, .51, .61 through .68, .71 through .74, .81, .82...

40 CFR 52.970 - Identification of plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Particulate Matter Jun 1988, LR14:348 06/15/89, 54 FR 25451 Ref 52.999(c)(50) Section 1303.A Toxic Substances... Stringent Regulations may be Prescribed if Particulates are Toxic Jun 1988, LR14:348 06/15/89, 54 FR 25451... Law 30:2060 N.6 Toxic air pollution emission control program 10/22/92 06/23/94, 59 FR 32359 Ref 52.999...

The 1989 long-range program plan

NASA Technical Reports Server (NTRS)

1988-01-01

The President's National Space Policy of 1988 reaffirms that space activities serve a variety of vital national goals and objectives, including the strengthening of U.S. scientific, technological, political, economic, and international leadership. The new policy stresses that civil space activities contribute significantly to enhancing America's world leadership. Goals and objectives must be defined and redefined, and each advance toward a given objective must be viewed as a potential building block for future programs. This important evolutionary process for research and development is reflected, describing NASA's program planning for FY89 and later years. This plan outlines the direction of NASA's future activities by discussing goals, objectives, current programs, and plans for the future. The 1989 plan is consistent with national policy for both space and aeronautics, and with the FY89 budget that the President submitted to Congress in February 1988.

Ohio Entrepreneurship Education Grant Winners Showcase (Columbus, Ohio, May 11, 1988).

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This publication contains over 80 descriptions of grant-winning entrepreneurship education programs offered in Ohio public schools. Each program description contains information on some or all of the following: sponsoring school(s), project title, purpose, target population, program format and content, site and time of program offering, project…

1988 Winners of the Cost Reduction Incentive Awards.

ERIC Educational Resources Information Center

National Association of College and University Business Officers, Washington, DC.

Outstanding cost-reduction programs implemented at colleges and universities during calendar year 1987 are recognized. Each of the 54 award-winning ideas is described in a paragraph-length program summary. Although some aspects of programs may be unique to a particular institution, creative administrators are challenged to tailor the programs to…

Distinctions among Accreditation Agencies for Business Programs

ERIC Educational Resources Information Center

Corcoran, Charles P.

2007-01-01

Over the past twenty years, business accreditation has become a growth industry. In 1988, some eleven percent of business programs were accredited by an accrediting body devoted solely to business program accreditation. Today, over forty-two percent boast of such external validation of their programs. Although the three principal accrediting…

Staging - SEER Registrars

Cancer.gov

Access tools for coding Extent of Disease 2018, plus Summary Staging Manual 2000, resources for comparison and mapping between staging systems, UICC information, and Collaborative Stage instructions and software.

Anti-drug Programs in the Workplace: Are They Here to Stay?

ERIC Educational Resources Information Center

Hayghe, Howard V.

1991-01-01

A 1990 survey indicated that, although the overall incidence of drug-testing programs among employers surveyed in 1988 were unchanged, the proportion with employee-assistance programs and formal, written policy statements regarding drug use among employees had increased. (Author/JOW)

Evaluation of the 8th AJCC staging system for pathologically versus clinically staged pancreatic adenocarcinoma: A time to revisit a dogma?

PubMed

Abdel-Rahman, Omar

2018-02-01

The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic exocrine adenocarcinoma has been released. The current study seeks to assess the 7th and 8th editions among patients registered within the surveillance, epidemiology and end results (SEER) database. SEER database (2010-2013) has been accessed through SEER*Stat program and AJCC 8th edition stages were reconstructed utilizing the collaborative stage descriptions. Kaplan-Meier analysis of overall survival and pancreatic cancer-specific survival analyses (according to both 7th and 8th editions and according to whether pathological or clinical staging were conducted) has been performed. Multivariate analysis of factors affecting pancreatic cancer-specific survival was also conducted through a Cox proportional hazard model. A total of 18  948 patients with pancreatic adenocarcinoma were identified in the period from 2010-2013. Pancreatic cancer-specific survival among pathologically staged patients and according to the 8th edition showed significant differences for all pair wise comparisons among different stages (P < 0.0001) except for the comparison between stage IA and stage IB (P = 0.307) and the comparison between stage IB and stage IIA (P = 0.116). Moreover, P value for stage IA vs IIA was 0.014; while pancreatic cancer-specific survival according to the 7th edition among pathologically staged patients showed significant differences for all pair wise comparisons among different stages (P < 0.0001) except for the comparison between IA and IB (P = 0.072), the comparison between stage IIA and stage IIB (P = 0.065), the comparison between stage IIA and stage III (P = 0.059) and the comparison between IIB and III (P = 0.595). Among clinically staged patients (i.e. those who did not undergo initial radical surgery), the prognostic performance of both 7th and 8th stages for both overall survival and pancreatic cancer-specific survival was limited. There is clearly a need to have two staging systems for pancreatic adenocarcinoma: pathological and clinical staging systems. Copyright © 2018 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.

Challenging a dogma; AJCC 8th staging system is not sufficient to predict outcomes of patients with malignant pleural mesothelioma.

PubMed

Abdel-Rahman, Omar

2017-11-01

The 8th edition of malignant pleural mesothelioma (MPM) American Joint Committee on Cancer (AJCC) staging system has been published. The current analysis aims to evaluate its performance in a population-based setting among patients recorded within the surveillance, epidemiology and end results (SEER) database. SEER database (2004-2013) has been accessed through SEER*Stat program and AJCC 8th edition stage groups were reconstructed. Survival analyses (overall and cancer-specific) were conducted according to 6th and 8th editions through Kaplan-Meier analysis. Cox-regression multivariate model was also utilized for pair wise comparisons between different prognostic groups for overall and cancer-specific survival. A total of 5382 patients with MPM were identified in the period from 2004 to 2013. According to the 6th edition, significant pair wise P values for overall survival included: IA vs. III (P=0.027); IA vs. IV: P<0.0001; IB vs. IV: P<0.0001; II vs. III: P<0.0001; II vs. IV: P<0.0001; III vs. IV: P<0.0001). According to the 8th edition, significant pair wise P values for overall survival included: all stages vs. IV: P<0.0001; IA vs. II: P=0.046; IA vs. IIIA: P=0.022; IA vs. IIIB: P <0.0001; IB vs. II: P<0.0001; IB vs. IIIB: P<0.0001; II vs. IIIA: P<0.0001; IIIA vs. IIIB: P<0.0001). C-index for 6th edition was 0.539 (SE: 0.008; 95% CI: 0.524-0.555); while C-index for 8th edition was 0.540 (SE: 0.008; 95% CI: 0.525-0.556). Based on the above findings, a simplified staging system was proposed and overall and cancer-specific survivals were evaluated according to the simplified system. For overall and cancer-specific survival assessment, P values for all pair wise comparisons among different stages were significant (<0.01). The prognostic performance of both the 6th and 8th AJCC editions is unsatisfactory; there is a need for a more practical and prognostically relevant staging system for MPM. Copyright © 2017 Elsevier B.V. All rights reserved.

Colorectal Specialization Increases Lymph Node Yield: Evidence from a National Database.

PubMed

Jeganathan, Arjun N; Shanmugan, Skandan; Bleier, Joshua I S; Hall, Glenn M; Paulson, Emily C

2016-07-01

Current guidelines recommend the evaluation of at least 12 lymph nodes (LNs) in the pathologic specimen following surgery for colorectal cancer (CRC). We sought to examine the role of colorectal specialization on nodal identification. We conducted a retrospective cohort study using SEER-Medicare data to examine the association between colorectal specialization and LN identification following surgery for colon and rectal adenocarcinoma between 2001 and 2009. Our dataset included patients >65 years who underwent surgical resection for CRC. We excluded patients with rectal cancer who had received neoadjuvant therapy. The primary outcome measure was the number of LNs identified in the pathologic specimen following surgery for CRC. Multivariate analysis was used to identify the association between surgical specialization and LN identification in the pathologic specimen. In multivariate analysis, odds of an adequate lymphadenectomy following surgery with a colorectal specialist were 1.32 and 1.41 times greater for colon and rectal cancer, respectively, than following surgery by a general surgeon (p < 0.001). These odds increased to 1.36 and 1.58, respectively, when analysis was limited to board-certified colorectal surgeons. Hospital factors associated with ≥12 LNs identified included high-volume CRC surgery (colon OR 1.84, p < 0.001; rectal OR 1.78, p < 0.001) and NCI-designated Cancer Centers (colon OR 1.75, p < 0.001; rectal OR 1.64; p = 0.007). Colorectal specialization and, in particular, board-certification in colorectal surgery, is significantly associated with increased LN identification following surgery for colon and rectal adenocarcinoma since the adoption of the 12-LN guideline in 2001.

40 CFR 147.2001 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands... Island § 147.2001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells on Indian lands in the State of Rhode Island is administered by EPA. This program consists of the...

40 CFR 147.2001 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program-Indian lands... Island § 147.2001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells on Indian lands in the State of Rhode Island is administered by EPA. This program consists of the...

40 CFR 147.2001 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands... Island § 147.2001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells on Indian lands in the State of Rhode Island is administered by EPA. This program consists of the...

40 CFR 147.2001 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program-Indian lands... Island § 147.2001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells on Indian lands in the State of Rhode Island is administered by EPA. This program consists of the...

40 CFR 147.2001 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program-Indian lands... Island § 147.2001 EPA-administered program—Indian lands. (a) Contents. The UIC program for all classes of wells on Indian lands in the State of Rhode Island is administered by EPA. This program consists of the...

Proceedings from the Communication Across the Curriculum Strand. NCA 2001 Summer Conference: Engaging 21st Century Communication Students.

ERIC Educational Resources Information Center

Dannels, Deanna; Jackson, Nancy; Robertson, Terry; Sheckles, Ted; Tomlinson, Stephanie

This Proceedings from the Communication across the Curriculum (CXC) strand of the National Communication Association's 2001 Summer Conference first highlights and describes five of the most common types of programs across the nation: Speaking Intensive Programs, Combined Speaking and Writing Programs, Discipline-Specific Programs, Faculty…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, D.W.; Heinrich, R.R.; Graczyk, D.G.

The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for fiscal year 1988 (October 1987 through September 1988). The Analytical Chemistry Laboratory is a full-cost recovery service center, with the primary mission of providing a broad range of analytical chemistry support services to the scientific and engineering programs at ANL. In addition, the ACL conducts a research program in analytical chemistry, works on instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL handles a wide range of analytical problems, from routinemore » standard analyses to unique problems that require significant development of methods and techniques.« less

NASA Historical Data Book. Volume 5; NASA Launch Systems, Space Transportation, Human Spaceflight and Space Science, 1979-1988

NASA Technical Reports Server (NTRS)

Rumerman, Judy A. (Compiler)

1999-01-01

In 1973, NASA published the first volume of the NASA Historical Data Book, a hefty tome containing mostly tabular data on the resources of the space agency between 1958 and 1968. There, broken into detailed tables, were the facts and figures associated with the budget, facilities, procurement, installations, and personnel of NASA during that formative decade. In 1988, NASA reissued that first volume of the data book and added two additional volumes on the agency's programs and projects, one each for 1958-1968 and 1969-1978. NASA published a fourth volume in 1994 that addressed NASA resources for the period between 1969 and 1978. This fifth volume of the NASA Historical Data Book is a continuation of those earlier efforts. This fundamental reference tool presents information, much of it statistical, documenting the development of four critical areas of NASA responsibility for the period between 1979 and 1988. This volume includes detailed information on the development and operation of launch systems, space transportation, human spaceflight, and space science during this era. As such, it contains in-depth statistical information about the early Space Shuttle program through the return to flight in 1988, the early efforts to build a space station, the development of new launch systems, and the launching of seventeen space science missions. A companion volume will appear late in 1999, documenting the space applications, support operations, aeronautics, and resources aspects of NASA during the period between 1979 and 1988. NASA began its operations as the nation's civilian space agency in 1958 following the passage of the National Aeronautics and Space Act. It succeeded the National Advisory Committee for Aeronautics (NACA). The new organization was charged with preserving the role of the United States "as a leader in aeronautical and space science and technology" and in its application, with expanding our knowledge of the Earth's atmosphere and space, and with exploring flight both within and outside the atmosphere. By the 1980s, NASA had established itself as an agency with considerable achievements on record. The decade was marked by the inauguration of the Space Shuttle flights and haunted by the 1986 Challenger accident that temporarily halted the program. The agency also enjoyed the strong support of President Ronald Reagan, who enthusiastically announced the start of both the Space Station program and the National Aerospace Plane program.

Criminal Investigation Program Report

DTIC Science & Technology

1988-10-31

Periodontal Resident for his paper "The Presence of Nicotine on Root Surfaces of Periodontally Diseased Teeth in Smokers" The paper based on Protocol #87-20...Closed Root 87-23 Planing with a Conventional Approach. (C) 31 1987 Evaluation of the Apical Seal Produced by Injected 87-32 Thermoplasticized Gutta...Freeze-Dried Bone. (0) 35 1988 Evaluation of Osseointegration of Titanium Dental 88-11 Implants in Micro Swine. (0) 36 1988 Experimental Periodontitis

Moving Forward with Modern Vocational Education Programs. Abstracts for Vocational Education Exemplary and Innovative Project Grants 1987-88, 1988-89.

ERIC Educational Resources Information Center

North Carolina State Dept. of Public Instruction, Raleigh. Div. of Vocational Education Services.

This volume provides a one-page abstract for each of the vocational exemplary and innovative projects in the state of North Carolina that were funded in 1987-88 and 1988-89 as authorized by the 1984 Carl D. Perkins Act. Each abstract provides the following information: title of project; local education authority; project coordinator; address;…

Public School Library Media Centers in South Carolina: A Survey of Service Levels Offered. Conducted during School Year 1988/1989.

ERIC Educational Resources Information Center

Townsend, Catherine M.

A state-wide survey was undertaken in 1988-1989 to determine the status of the library media programs in South Carolina's public schools. The first of two phases of the study involved the compilation of statistical data reported to the State Department of Education by building level administrators on the Basic Educational Data System (BEDS) for…

Mercer County Community College Remedial Program Assessment, August 1988. Two Year Follow-Up of the Fall 1986 Cohort.

ERIC Educational Resources Information Center

Porter, Al

This assessment of New Jersey's Mercer County Community College's (MCCC's) remedial program provides a program overview, results of a two-year follow-up of fall 1986 remedial students, and comparative data from previous years. The program overview examines policies and procedures concerning placement criteria, exit standards, program acceptance,…

78 FR 73195 - Privacy Act of 1974: CMS Computer Matching Program Match No. 2013-01; HHS Computer Matching...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-05

.... Description of the Matching Program A. General The Computer Matching and Privacy Protection Act of 1988 (Pub... 1974: CMS Computer Matching Program Match No. 2013-01; HHS Computer Matching Program Match No. 1312...). ACTION: Notice of Computer Matching Program (CMP). SUMMARY: In accordance with the requirements of the...

The increase in international medical graduates in family practice residency programs.

PubMed

Koehn, Nerissa N; Fryer, George E; Phillips, Robert L; Miller, John B; Green, Larry A

2002-06-01

The number of filled positions in family practice residency programs decreased by 18.6% from 1997-2001. This study sought to determine the degree of reliance on international medical graduates (IMGs) to fill family practice residency positions and the relative proportion of US citizen IMGs. We analyzed the 1992-2001 National Resident Matching Program results, the 2000 American Medical Association Masterfile, and the 1992-2001 American Academy of Family Physicians Annual Survey of Family Practice Residency Programs. The percentage of IMGs matching in family practice remained stable between the years of 1992-1996 (10.0%-11.8%) but since 1997 has increased to a high of 21.4% in 2001. This rise in IMGs corresponds with a drop in the total percentage of family practice residency positions filled in the Match from 90.5% in 1996 to 76.3% in 2001. Despite the drop in Match numbers, the percentage of first-year family practice positions filled in July has remained in the range of 95.5%-97.8% since 1996. IMGs account for an increasing percentage of post-Match fills from 16.7% in 1996 to 47.9% in 2001. In 1999, a majority of family practice programs (279 [55.6%]), had at least one IMG. Of these, 48 programs (9.6%) had at least 50% of residents who were IMGs, and eight programs (1.6%) were entirely composed of IMGs. In five states (Connecticut, Illinois, Michigan, New Jersey, and New York), more than 25% of family practice residents were IMGs. Family practice is becoming increasingly reliant on IMGs to fill residency positions.

Declining MIS Enrollment: The Death of the MIS Degree?

ERIC Educational Resources Information Center

Saunders, Gary; Lockridge, T. Maurice

2011-01-01

There is little doubt that enrollments in MIS degree programs have been declining since the recession in the technical industry in 2001. Reagan's research (2008) indicates that enrollments in MIS degree programs is only about 25% of the 2001 level. Many MIS (IS) programs have been abandoned or combined with other related programs. While many…

Evaluation and Validation: A Look at the Program Effectiveness Panel.

ERIC Educational Resources Information Center

Cook, Nancy R.; And Others

The work of the Program Effectiveness Panel (PEP) of the United States Department of Education was examined. The PEP is the Department of Education's primary means of certifying or validating the effectiveness of educational programs. Thirty-three educational programs were validated by the PEP between January 1988 and December 1990. Over time,…

Summer Splash. 1988 Wisconsin Summer Library Program Manual. Bulletin No. 8230.

ERIC Educational Resources Information Center

Lamb, Donald K.; And Others

A compilation of materials contributed by and developed with the cooperation of Wisconsin librarians and Ohio's 1987 summer reading program, this planning manual provides guidelines for planning and promoting summer programs for young people by librarians in the state of Wisconsin. The theme of the program, "Summer Splash," is intended…

40 CFR 147.2601 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 24 2013-07-01 2013-07-01 false EPA-administered program-Indian lands....2601 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the... effective date for the UIC program on Indian lands in the territory of Guam is November 25, 1988. [53 FR...

40 CFR 147.2601 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 23 2014-07-01 2014-07-01 false EPA-administered program-Indian lands....2601 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the... effective date for the UIC program on Indian lands in the territory of Guam is November 25, 1988. [53 FR...

40 CFR 147.2601 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 23 2011-07-01 2011-07-01 false EPA-administered program-Indian lands....2601 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the... effective date for the UIC program on Indian lands in the territory of Guam is November 25, 1988. [53 FR...

40 CFR 147.2601 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false EPA-administered program-Indian lands....2601 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the... effective date for the UIC program on Indian lands in the territory of Guam is November 25, 1988. [53 FR...

40 CFR 147.2601 - EPA-administered program-Indian lands.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 24 2012-07-01 2012-07-01 false EPA-administered program-Indian lands....2601 EPA-administered program—Indian lands. (a) Contents. The UIC program for Indian lands in the... effective date for the UIC program on Indian lands in the territory of Guam is November 25, 1988. [53 FR...

Lake Roosevelt Fisheries Monitoring Program; 1988-1989 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peone, Tim L.; Scholz, Allan T.; Griffith, James R.

1990-10-01

In the Northwest Power Planning Council's 1987 Columbia River Basin Fish and Wildlife Program (NPPC 1987), the Council directed the Bonneville Power Administration (BPA) to construct two kokanee salmon (Oncorhynchus nerka) hatcheries as partial mitigation for the loss of anadromous salmon and steelhead incurred by construction of Grand Coulee Dam [Section 903 (g)(l)(C)]. The hatcheries will produce kokanee salmon for outplanting into Lake Roosevelt as well as rainbow trout (Oncorhynchus mykiss) for the Lake Roosevelt net-pen program. In section 903 (g)(l)(E), the Council also directed BPA to fund a monitoring program to evaluate the effectiveness of the kokanee hatcheries. Themore » monitoring program included the following components: (1) a year-round, reservoir-wide, creel survey to determine angler use, catch rates and composition, and growth and condition of fish; (2) assessment of kokanee, rainbow, and walleye (Stizostedion vitreum) feeding habits and densities of their preferred prey, and; (3) a mark and recapture study designed to assess the effectiveness of different locations where hatchery-raised kokanee and net pen reared rainbow trout are released. The above measures were adopted by the Council based on a management plan, developed by the Upper Columbia United Tribes Fisheries Center, Spokane Indian Tribe, Colville Confederated Tribes, Washington Department of Wildlife, and National Park Service, that examined the feasibility of restoring and enhancing Lake Roosevelt fisheries (Scholz et al. 1986). In July 1988, BPA entered into a contract with the Spokane Indian Tribe to initiate the monitoring program. The projected duration of the monitoring program is through 1995. This report contains the results of the monitoring program from August 1988 to December 1989.« less

Implications of inaccurate clinical nodal staging in pancreatic adenocarcinoma.

PubMed

Swords, Douglas S; Firpo, Matthew A; Johnson, Kirsten M; Boucher, Kenneth M; Scaife, Courtney L; Mulvihill, Sean J

2017-07-01

Many patients with stage I-II pancreatic adenocarcinoma do not undergo resection. We hypothesized that (1) clinical staging underestimates nodal involvement, causing stage IIB to have a greater percent of resected patients and (2) this stage-shift causes discrepancies in observed survival. The Surveillance, Epidemiology, and End Results (SEER) research database was used to evaluate cause-specific survival in patients with pancreatic adenocarcinoma from 2004-2012. Survival was compared using the log-rank test. Single-center data on 105 patients who underwent resection of pancreatic adenocarcinoma without neoadjuvant treatment were used to compare clinical and pathologic nodal staging. In SEER data, medium-term survival in stage IIB was superior to IB and IIA, with median cause-specific survival of 14, 9, and 11 months, respectively (P < .001). Seventy-two percent of stage IIB patients underwent resection vs 28% in IB and 36% in IIA (P < .001). In our institutional data, 12.4% of patients had clinical evidence of nodal involvement vs 69.5% by pathologic staging (P < .001). Among clinical stage IA-IIA patients, 71.6% had nodal involvement by pathologic staging. Both SEER and institutional data support substantial underestimation of nodal involvement by clinical staging. This finding has implications in decisions regarding neoadjuvant therapy and analysis of outcomes in the absence of pathologic staging. Copyright © 2017 Elsevier Inc. All rights reserved.

Disparities in Use of Gynecologic Oncologists for Women with Ovarian Cancer in the United States

PubMed Central

Austin, Shamly; Martin, Michelle Y; Kim, Yongin; Funkhouser, Ellen M; Partridge, Edward E; Pisu, Maria

2013-01-01

Objective To examine disparities in utilization of gynecologic oncologists (GOs) across race and other sociodemographic factors for women with ovarian cancer. Data Sources Obtained SEER-Medicare linked dataset for 4,233 non-Hispanic White, non-Hispanic African American, Hispanic of any race, and Non-Hispanic Asian women aged ≥66 years old diagnosed with ovarian cancer during 2000–2002 from 17 SEER registries. Physician specialty was identified by linking data to the AMA master file using Unique Physician Identification Numbers. Study Design Retrospective claims data analysis for 1999–2006. Logistic regression models were used to analyze the association between GO utilization and race/ethnicity in the initial, continuing, and final phases of care. Principal Findings GO use decreased from the initial to final phase of care (51.4–28.8 percent). No racial/ethnic differences were found overall and by phase of cancer care. Women >70 years old and those with unstaged disease were less likely to receive GO care compared to their counterparts. GO use was lower in some SEER registries compared to the Atlanta registry. Conclusions GO use for the initial ovarian cancer treatment or for longer term care was low but not different across racial/ethnic groups. Future research should identify factors that affect GO utilization and understand why use of these specialists remains low. PMID:23206237

Nonmethane organic compound monitoring program. Final report 1988. Volume 2. Urban air toxics monitoring program

DOE Office of Scientific and Technical Information (OSTI.GOV)

McAllister, R.A.; Moore, W.H.; Rice, J.

1989-04-01

From October, 1987 to October, 1988 samples of ambient air were collected at 19 sites in the eastern part of the U.S. Every 12 days, air was integrated over 24-hour periods into passivated stainless steel canisters. Simultaneously, air was drawn through cartridges containing dinitrophenylhydrazine to collect carbonyl compounds. The samples were analyzed at a central laboratory for a total of 37 halogenated and aromatic hydrocarbons, formaldehyde, acetaldehyde, and other oxygenated species. The hydrocarbon species were analyzed by gas chromatography/multiple detectors and gas chromatography/mass spectrometry, while the carbonyl species were analyzed by liquid chromatography. An extensive quality assurance program was carriedmore » on to secure high quality data. Complete data for all the hydrocarbon samples are presented in the report.« less

Academic Year Abroad. 1988-89.

ERIC Educational Resources Information Center

Howard, Edrice Marguerite, Ed.

This directory of study-abroad programs provides information on over 1,500 postsecondary study programs that take place in countries other than the United States during the academic year. An introductory section describes the organization of the listings (which provide program sponsor and name, location, dates, subjects, credit, eligibility,…

LAMA Preconference and Program Highlights.

ERIC Educational Resources Information Center

Library Administration & Management, 1988

1988-01-01

Highlights events of the Library Administration and Management Association 1988 conference, including presentation of awards and programs on: (1) transfer of training; (2) hiring; (3) mentoring; (4) acquisitions automation; (5) library building consultation; and (6) managing shared systems. (MES)

Microgravity Science and Applications Program tasks, 1988 revision

NASA Technical Reports Server (NTRS)

1989-01-01

The active research tasks as of the end of the fiscal year 1988 of the Microgravity Science and Applications Program, NASA-Office of Space Science and Applications, involving several NASA centers and other organizations are compiled. The purpose is to provide an overview of the program scope for managers and scientists in industry, university, and government communities. Also included are an introductory description of the program, the strategy and overall goal, identification of the organizational structures and people involved, and a description of each task. A list of recent publications is provided. The tasks are grouped into six major categories: electronic materials; solidification of metals, alloys, and composites; fluid dynamics and transport phenomena; biotechnology; glasses and ceramics; and combustion. Other categories include experimental technology, general studies and surveys; foreign government affiliations; industrial affiliations; and Physics And Chemistry Experiments (PACE). The tasks are divided into ground-based and flight experiments.

Tucannon River Spring Chinook Salmon Captive Broodstock Program, Annual Report 2001.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gallinat, Michael P.; Bumgarner, Joseph D.

2002-05-01

This report summarizes the objectives, tasks, and accomplishments of the Tucannon River spring chinook captive brood during 2001. The WDFW initiated a captive broodstock program in 1997. The overall goal of the Tucannon River captive broodstock program is for the short-term, and eventually long-term, rebuilding of the Tucannon River spring chinook salmon run, with the hope that natural production will sustain itself. The project goal is to rear captive salmon selected from the supplementation program to adults, spawn them, rear their progeny, and release approximately 150,000 smolts annually into the Tucannon River between 2003-2007. These smolt releases, in combination withmore » the current hatchery supplementation program (132,000 smolts) and wild production, are expected to produce 600-700 returning adult spring chinook to the Tucannon River each year from 2005-2010. The captive broodstock program will collect fish from five (1997-2001) brood years (BY). The captive broodstock program was initiated with 1997 BY juveniles, and the 2001 BY fish have been selected. As of Jan 1, 2002, WDFW has 17 BY 1997, 159 BY 1998, 316 BY 1999, 448 BY 2000, and approximately 1,200 BY 2001 fish on hand at LFH. The 2001 eggtake from the 1997 brood year (Age 4) was 233,894 eggs from 125 ripe females. Egg survival was 69%. Mean fecundity based on the 105 fully spawned females was 1,990 eggs/female. The 2001 eggtake from the 1998 brood year (Age 3) was 47,409 eggs from 41 ripe females. Egg survival was 81%. Mean fecundity based on the 39 fully spawned females was 1,160 eggs/female. The total 2001 eggtake from the captive brood program was 281,303 eggs. As of May 1, 2002 we have 171,495 BY 2001 captive brood progeny on hand. A total of 20,592 excess fish were marked as parr (AD/CWT) and will be released during early May, 2002 into the Tucannon River (rkm 40-45). This will allow us to stay within our maximum allowed number (150,000) of smolts released. During April 2002, WDFW volitionally released 3,055 BY 2000 captive broodstock progeny from Curl Lake Acclimation Pond into the Tucannon River. These fish were marked with agency-only wire tags and no fin clips in order to differentiate them from the supplementation fish (CWT/Right Red VI/No Finclip). Monitoring their survival and future releases to adult returns, along with future natural production levels, will determine the success or failure of this captive broodstock program.« less

Surface-water-quality assessment of the Upper Illinois River basin in Illinois, Indiana, and Wisconsin : data on manmade nonagricultural volatile and semivolatile organic chemicals in water, May 1988 through March 1990

USGS Publications Warehouse

Fitzpatrick, F.A.; Colman, J.A.

1993-01-01

This report contains data from the survey of manmade nonagricultural volatile and semivolatile organic chemicals in surface water in the upper Illinois River basin from May 1988 through March l990. In addition to the data, sampling methods and quality-assurance procedures are described. The survey was part of the upper Illinois River basin pilot project of the National Water-Quality Assessment program conducted by the U.S. Geological Survey. The organic chemicals analyzed from the water samples were those expected to be associated primarily with effluent from point sources in urban areas. A low-flow synoptic investigation of 52 volatile and 54 semivolatile organic chemicals was conducted at 31 sites in July 1988. Additional samples were collected monthly at two sites to continue to test for the presence of 43 volatile organic chemicals from December 1988 through March l990, and of all semivolatile organic chemicals at two sites from August through September 1988.

Accreditation of University Undergraduate Programs in Nigeria from 2001-2012: Implications for Graduates Employability

ERIC Educational Resources Information Center

Dada, M. S.; Imam, Hauwa

2015-01-01

This study analysed accreditation exercises of universities undergraduate programs in Nigeria from 2001-2013. Accreditation is a quality assurance mechanism to ensure that undergraduate programs offered in Nigeria satisfies benchmark minimum academic standards for producing graduates with requisite skills for employability. The study adopted the…

Lymph node status as a prognostic factor after palliative resection of primary tumor for patients with metastatic colorectal cancer.

PubMed

Li, Qingguo; Wang, Changjian; Li, Yaqi; Li, Xinxiang; Xu, Ye; Cai, Guoxiang; Lian, Peng; Cai, Sanjun

2017-07-18

Lymph node (LN) status is one of the most important predictors for M0 colorectal cancer patients. However, its clinical impact on stage IV colorectal cancer remains unclear. The study aimed to explore the prognostic value of LN status after palliative resection of primary tumor for patients with metastatic colorectal cancer (mCRC). We combined analyses of mCRC patients in Surveillance, Epidemiology and End Results (SEER) database and Fudan University Shanghai Cancer Center (FUSCC).A total of 17,553 patients with mCRC were identified in SEER database. X-tile program was adopted to identify 2 and 10 as optimal cutoff values for negative lymph node (NLN) count to divide patients into 3 subgroups of high, middle and low risk of cancer related death. N stage and NLN count were verified as independent prognostic factors in multivariate analyses of patients in whole cohort and in subgroup analyses of each N stage (P<0.05). Validation of FUSCC cohort of patients demonstrated that metastatic tumor burden (P = 0.042), NLN count (P = 0.039) and sequential chemotherapy (P = 0.040) were significant predictors of poorer CSS. Specifically, the prognosis of patients at stage N0 was significantly more favorable than that of patients at stage N2 (P = 0.038). In conclusion, primary tumor LN status was a strong predictor of CSS after palliative resection of metastatic colorectal cancer. Advanced N stage and small number of NLN were correlated with high risk of cancer related death after palliative resection of primary tumor.

Demographic, Clinical, and Treatment Trends Among Women Diagnosed with Vulvar Cancer in the U.S.

PubMed Central

AM, Stroup; LC, Harlan; EL, Trimble

2008-01-01

Objective Describe the treatment and survival patterns among a population-based sample of vulvar cancer patients diagnosed in the U.S. in 1999. Methods Cases were identified for the National Cancer Institute’s Patterns of Care Study (POC) using Surveillance, Epidemiology, and End Results Program (SEER). A stratified random sample of non-Hispanic white, non-Hispanic black, and Hispanic women age 20 and older was selected from cases reported by eleven SEER registries. Analyses of the association between vulvar cancer and key demographic, clinical, and hospital characteristics by stage were performed. Cox proportional hazards was used to estimate the odds of death due to cancer. All estimates were weighted, and analyses were conducted with SUDAAN. Results 90% of cases were diagnosed with in situ or early stage invasive disease. Older patients were more likely to present at advanced stages. 25% of women with Stage III–IV vulvar cancer received chemotherapy plus radiation. We noted widespread use of radical local excision among women with Stage I/II cancer, but 46%–54% with invasive disease underwent a radical or total vulvectomy. Factors associated with cancer death were limited to age and stage. Women 75 years and older were at higher risk compared to women aged 20–49 and the risk of death increased with advancing stage. Conclusions Vulvar cancer is diagnosed at early stages. Late stage disease is associated with a significant increase in mortality. Radical surgery was still commonly performed in 1999. Radiation was more common in women diagnosed at late stage, while the use of chemoradiation remained limited. PMID:18155274

Variation in Adherence to External Beam Radiotherapy Quality Measures Among Elderly Men With Localized Prostate Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bekelman, Justin E.; Zelefsky, Michael J.; Jang, Thomas L.

2007-12-01

Purpose: To characterize the variation in adherence to quality measures of external beam radiotherapy (EBRT) for localized prostate cancer and its relation to patient and provider characteristics in a population-based, representative sample of U.S. men. Methods and Materials: We evaluated EBRT quality measures proposed by a RAND expert panel of physicians among men aged {>=}65 years diagnosed between 2000 and 2002 with localized prostate cancer and treated with primary EBRT using data from the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare program. We assessed the adherence to five EBRT quality measures that were amenable to analysis using SEER-Medicare data: (1)more » use of conformal RT planning; (2) use of high-energy (>10-MV) photons; (3) use of custom immobilization; (4) completion of two follow-up visits with a radiation oncologist in the year after therapy; and (5) radiation oncologist board certification. Results: Of the 11,674 patients, 85% had received conformal RT planning, 75% had received high-energy photons, and 97% had received custom immobilization. One-third of patients had completed two follow-up visits with a radiation oncologist, although 91% had at least one visit with a urologist or radiation oncologist. Most patients (85%) had been treated by a board-certified radiation oncologist. Conclusions: The overall high adherence to EBRT quality measures masked substantial variation in geography, socioeconomic status in the area of residence, and teaching affiliation of the RT facility. Future research should examine the reasons for the variations in these measures and whether the variation is associated with important clinical outcomes.« less

Survival of patients with hepatocellular carcinoma in the San Joaquin Valley: a comparison with California Cancer Registry data.

PubMed

Atla, Pradeep R; Sheikh, Muhammad Y; Mascarenhas, Ranjan; Choudhury, Jayanta; Mills, Paul

2012-01-01

Variation in the survival of patients with hepatocellular carcinoma (HCC) is related to racial differences, socioeconomic disparities and treatment options among different populations. A retrospective review of the data from medical records of patients diagnosed with HCC were analyzed at an urban tertiary referral teaching hospital and compared to patients in the California Cancer Registry (CCR) - a participant in the Survival Epidemiology and End Results (SEER)program of the National Cancer Institute (NCI). The main outcome measure was overall survival rates. 160 patients with the diagnosis of HCC (M/F=127/33), mean age 59.7±10 years, 32% white, 49% Hispanic, 12% Asian and 6% African American. Multivariate analysis identified tumor size, model for end-stage liver disease (MELD) score, portal vein invasion and treatment offered as the independent predictors of survival (p <0.05). Survival rates across racial groups were not statistically significant. 5.6% received curative treatments (orthotopic liver transplantation, resection, rediofrequency ablation) (median survival 69 months), 34.4% received nonsurgical treatments (trans-arterial chemoembolization, systemic chemotherapy) (median survival 9 months), while 60% received palliative or no treatment (median survival 3 months) (p <0.001). There was decreased survival in our patient population with HCC beyond 2 years. 60% of our study population received only palliative or no treatment suggesting a possible lack of awareness of chronic liver disease as well as access to appropriate surveillance modalities. Ethnic disparities such as Hispanic predominance in this study in contrast to the CCR/SEER database may have been a contributing factor for poorer outcome.

75 FR 11632 - Proposed Collection; Comment Request for Notice 2001-1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... comments concerning Notice 2001-1, Employer-designed Tip Reporting Program for the Food and Beverage... Reporting Program for the Food and Beverage Industry (EmTRAC). OMB Number: 1545-1716. Notice Number: Notice...

Model for assessment of the velocity and force at the start of sprint race.

PubMed

Janjić, Nataša J; Kapor, Darko V; Doder, Dragan V; Petrović, Aleksandar; Jarić, Slobodan

2017-02-01

A mathematical model was developed for the assessment of the starting velocity and initial velocity and force of a 100-m sprint, based on a non-homogeneous differential equation with the air resistance proportional to the velocity, and the initial conditions for [Formula: see text], [Formula: see text]The use of this model requires the measurement of reaction time and segmental velocities over the course of the race. The model was validated by comparison with the data obtained from 100-m sprints of men: Carl Lewis (1988), Maurice Green (2001) and Usain Bolt (2009), and women: Florence Griffith-Joyner, Evelyn Ashford and Drechsler Heike (1988) showing a high level of agreement. Combined with the previous work of the authors, the present model allows for the assessment of important physical abilities, such as the exertion of a high starting force, development of high starting velocity and, later on, maximisation of the peak running velocity. These data could be of importance for practitioners to identify possible weaknesses and refine training methods for sprinters and other athletes whose performance depend on rapid movement initiations.

More Cancer Types - SEER Cancer Stat Facts

Cancer.gov

Cancer Statistical Fact Sheets are summaries of common cancer types developed to provide an overview of frequently-requested cancer statistics including incidence, mortality, survival, stage, prevalence, and lifetime risk.

Building America Case Study: Impact of Improved Duct Insulation on Fixed-Capacity (SEER 13) and Variable-Capacity (SEER 22) Heat Pumps, Cocoa, Florida

DOE Office of Scientific and Technical Information (OSTI.GOV)

C. Withers, J. Cummings, B. Nigusse, E. Martin

A new generation of central, ducted variable-capacity heat pump systems has come on the market, promising very high cooling and heating efficiency. Instead of cycling on at full capacity and then cycling off when the thermostat is satisfied, they vary their cooling and heating output over a wide range (approximately 40 to 118% of nominal full capacity); thus, staying 'on' for 60% to 100% more hours per day compared to fixed-capacity systems. Current Phase 4 experiments in an instrumented lab home with simulated occupancy evaluate the impact of duct R-value enhancement on the overall operating efficiency of the variable-capacity systemmore » compared to the fixed-capacity system.« less

The concept of a hierarchical cosmos

NASA Astrophysics Data System (ADS)

Grujić, P. V.

2003-10-01

The idea of a hierachically structured cosmos can be traced back to the Presocratic Hellada. In the fifth century BC Anaxagoras from Clazomenae developed an idea of a sort of fractal material world, by introducing the concept of seeds (spermata), or homoeomeries as Aristotle dubbed it later (Grujić 2001). Anaxagoras ideas have been grossly neglected during the Middle Ages, to be invoked by a number of post-Renaissance thinkers, like Leibniz, Kant, etc, though neither of them referred to their Greek predecessor. But the real resurrections of the hierarchical paradigm started at the beginning of the last century, with Fournier and Charlier (Grujić 2002). Second half of the 20th century witnessed an intensive development of the theoretical models based on the (multi)fractal paradigm, as well as a considerable body of the observational evidence in favour of the hierarchical cosmos (Saar 1988). We overview the state of the art of the cosmological fractal concept, both within the astrophysical (Sylos Labini et al 1998), methodological (Ribeiro 2001) and epistemological (Ribeiro and Videira 1998) context.

Development of a System-Wide Predator Control Program: Stepwise Implementation of a Predation Index, Predator Control Fisheries, and Evaluation Plan in the Columbia River Basin; Northern Pikeminnow Management Program, 2001 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Porter, Russell G.; Winther, Eric C.; Fox, Lyle G.

2003-03-01

This report presents results for year eleven in a basin-wide program to harvest northern pikeminnow (Ptychocheilus oregonensis). This program was started in an effort to reduce predation by northern pikeminnow on juvenile salmonids during their emigration from natal streams to the ocean. Earlier work in the Columbia River Basin suggested predation by northern pikeminnow on juvenile salmonids might account for most of the 10-20% mortality juvenile salmonids experience in each of eight Columbia River and Snake River reservoirs. Modeling simulations based on work in John Day Reservoir from 1982 through 1988 indicated that, if predator-size northern pikeminnow were exploited atmore » a 10-20% rate, the resulting restructuring of their population could reduce their predation on juvenile salmonids by 50%. To test this hypothesis, we implemented a sport-reward angling fishery and a commercial longline fishery in the John Day Pool in 1990. We also conducted an angling fishery in areas inaccessible to the public at four dams on the mainstem Columbia River and at Ice Harbor Dam on the Snake River. Based on the success of these limited efforts, we implemented three test fisheries on a system-wide scale in 1991--a tribal longline fishery above Bonneville Dam, a sport-reward fishery, and a dam-angling fishery. Low catch of target fish and high cost of implementation resulted in discontinuation of the tribal longline fishery. However, the sport-reward and dam-angling fisheries were continued in 1992 and 1993. In 1992, we investigated the feasibility of implementing a commercial longline fishery in the Columbia River below Bonneville Dam and found that implementation of this fishery was also infeasible.« less

Criteria for Pruning Academic Programs: Actual vs. Ideal. ASHE 1988 Annual Meeting Paper.

ERIC Educational Resources Information Center

Ross, Cynthia S.; Gardiner, John J.

Two decades following the publication of David G. Brown's "Criteria for Pruning Programs," (which recognized that traditional financial support to higher education was decreasing and proposed 10 guidelines for evaluating existing programs) a study was developed to determine what criteria are actually being used by comprehensive…

Report on National Collegiate Alcohol Awareness Week Fall 1989.

ERIC Educational Resources Information Center

Rapaport, Ross J.; And Others

Central Michigan University has been systematically addressing alcohol and other drug problems on its campus through an Alcohol and Drug Abuse Intervention and Prevention Program (ADAIPP) which provides structure, coordination, and support for a number of coexisting programs on campus. During the 1988-89 academic year, these programs culminated in…

1988 Washington State Program for Migrant Children's Education.

ERIC Educational Resources Information Center

de la Rosa, Raul

This comprehensive report on the Washington State program for migrant children's education was compiled by the state education department in order to comply with federal and state funding requirements. It is divided into four parts: (1) Federal Assistance Application; (2) Program Narrative; (3) Budget Information; and (4) Assurances. The program…

Horizons. A Guide to Postsecondary Education in Ontario, 1988/89.

ERIC Educational Resources Information Center

Ontario Ministry of Colleges and Universities, Toronto.

A guide to postsecondary opportunities in Ontario (Canada) is presented to help students choose a course of study after completing secondary school. Information is presented on student costs and student financial aid and the Colleges of Applied Arts and Technology. Apprenticeship programs, diploma programs, and certificate programs are identified…

Summer Institute for Career Exploration (ICE), 1988. OREA Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Rosenberg, Jan

In its fourth year, the English-as-a-Second-Language (ESL) component of the Summer Institute for Career Exploration (ICE) program was funded by the federal government's Emergency Immigrant Education Assistance program. Program goals were to help recent immigrants develop English language skills, introduce students to high school requirements and…

Community College Exemplary Instructional Programs, 1988-1989.

ERIC Educational Resources Information Center

Fideler, Elizabeth F., Ed.; Bazer, Gerald, Ed.

Second in an annual series, this volume presents brief descriptions of a number of outstanding community college instructional programs identified by the National Council of Instructional Administrators (NCIA). Each description includes the address and telephone number of the college in which the program operates, and the names of the college…

Cooperative Education in New Mexico.

ERIC Educational Resources Information Center

New Mexico Commission on Higher Education.

In 1988, the State Legislature created the New Mexico Cooperative Program to develop and expand cooperative education (co-op) programs. The Commission on Higher Education (CHE) was designated to help institutions establish and expand programs and collect information. For reporting purposes, CHE required that, in order to be considered co-op, work…

Relationship Education with Adolescent Parents: Challenges and Lessons Learned

ERIC Educational Resources Information Center

Toews, Michelle; Yazedjian, Ani

2009-01-01

In 1988, the Texas Legislature established a pilot program for pregnant and parenting adolescents (Texas Education Agency, n.d.). This program was developed with the goal of enabling adolescent parents to become self-sufficient, responsible, job-oriented citizens. Although the program is not mandated by the state, Pregnancy, Education, and…

Literacy Program. National Issues Forums Special Report.

ERIC Educational Resources Information Center

National Issues Forums, Dayton, OH.

In the spring of 1988, 33 representatives from 20 institutions or organizations sponsoring National Issues Forum (NIF) literacy programs attended a national conference in Washington, D.C. Throughout the conference, representatives from the organizations sponsoring NIF literacy programs made statements on the importance of NIF as a tool for…

15 CFR 2001.3 - Functions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Functions. 2001.3 Section 2001.3... TRADE REPRESENTATIVE CREATION, ORGANIZATION, AND FUNCTIONS § 2001.3 Functions. (a) The Trade... agreements, and other matters which are related to the trade agreements program; (4) Performs the functions...

23 CFR 200.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Purpose. 200.1 Section 200.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.1 Purpose. To provide guidelines for: (a) Implementing the Federal Highway...

23 CFR 200.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Purpose. 200.1 Section 200.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.1 Purpose. To provide guidelines for: (a) Implementing the Federal Highway...

23 CFR 200.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Purpose. 200.1 Section 200.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.1 Purpose. To provide guidelines for: (a) Implementing the Federal Highway...

23 CFR 200.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Purpose. 200.1 Section 200.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS TITLE VI PROGRAM AND RELATED STATUTES-IMPLEMENTATION AND REVIEW PROCEDURES § 200.1 Purpose. To provide guidelines for: (a) Implementing the Federal Highway...

Leninism with a Human Face: National Strategy in Lee Kuan Yew’s Singapore

DTIC Science & Technology

1996-09-13

1 c ?I. Turnball, A H_zstory of Singapore, 1819-1988 Singapore- Oxford Unlverslty Tress, 1988) 297. --How to maintain domestic political stability given... political stability . Accordingly, many 2rc3grams wit-? obszenslbly dl5ferent goals carried a "unlzyl twist. For example, the housing modernization program...transforming Singapore into an economic sowerhouse, enztancinq political stability , while maintaining :and perhaps even increasing) social cohesion is an

Educational Excellence of Asian Americans: Myth or Reality? Papers presented at the Asian/Pacific Librarians Association Program of the 1988 American Library Association Convention (New Orleans, Louisiana, July 11, 1988).

ERIC Educational Resources Information Center

Karkhanis, Sharad, Ed.; Tsai, Betty L., Ed.

This collection of three conference papers explores the myth of the educational excellence of Asian Americans. "The National Perspective" (L. Wright) contends that the educational success of Asian Americans is not a myth and that lessons drawn from the example of the academic achievement of Asian Americans can be applied to American…

Military Advertising Exposure and Service Images: Findings from the 1988 Youth Attitude Tracking Study II

DTIC Science & Technology

1989-01-01

Research Program which contributes to policy formulation and the development of recruiting marketing strategies . The Military Services provide comments and... market group reporting awareness of military advertising stayed the same or increased from 1986 to 1988 for all Services, but still remained below 1984... advertising awareness. All of the market groups show nearly identical patterns regarding order of mention on the first response, and even the 16 Figure

Proceedings of the Annual Meeting of the Mid-South Educational Research Association: Containing the Abstracts of Discussion Sessions, Display Sessions, Symposia, and Training Sessions (17th, Louisville, Kentucky, November 9-11, 1988).

ERIC Educational Resources Information Center

Petry, John R., Ed.; Guth, Lorraine J., Ed.

Abstracts of papers presented during discussion and display sessions, symposia, and training sessions at the Mid-South Educational Research Association (MSERA) Annual Meeting in 1988 are presented. Papers presented during the display sessions discuss the following topics: the use of data maps for displaying/analyzing statistical data; programs for…

Technology for large space systems: A bibliography with indexes (supplement 20)

NASA Technical Reports Server (NTRS)

1989-01-01

This bibliography lists 694 reports, articles, and other documents introduced into the NASA Scientific and Technical Information System between July, 1988 and December, 1988. Its purpose is to provide helpful information to the researcher or manager engaged in the development of technologies related to large space systems. Subject areas include mission and program definition, design techniques, structural and thermal analysis, structural dynamics and control systems, electronics, advanced materials, assembly concepts, and propulsion.

40 CFR 272.2201 - Texas State-Administered Program: Final Authorization.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Management Program, June, 2005. Copies of the document can be obtained from U.S. EPA Region 6, 1445 Ross... Statement dated November 21, 1986, July 21, 1988, December 4, 1989, April 11, 1990, July 31, 1991, February...

A Comprehensive Review of Selected Business Programs in Community Colleges and Area Vocational-Technical Centers. Program Review Report.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Div. of Vocational, Adult, and Community Education.

In 1988, a review was conducted of the business component of associate in arts and associate in science (AS) degree programs, and of the certificate programs in business in Florida community colleges and area vocational-technical centers. Focusing primarily on business programs in marketing, general business management, and small business…

Menu-Driven Solver Of Linear-Programming Problems

NASA Technical Reports Server (NTRS)

Viterna, L. A.; Ferencz, D.

1992-01-01

Program assists inexperienced user in formulating linear-programming problems. A Linear Program Solver (ALPS) computer program is full-featured LP analysis program. Solves plain linear-programming problems as well as more-complicated mixed-integer and pure-integer programs. Also contains efficient technique for solution of purely binary linear-programming problems. Written entirely in IBM's APL2/PC software, Version 1.01. Packed program contains licensed material, property of IBM (copyright 1988, all rights reserved).

Did You Know? Video Series - SEER Cancer Statistics

Cancer.gov

Videos that explain cancer statistics. Choose from topics including survival, statistics overview, survivorship, disparities, and specific cancer types including breast, lung, colorectal, prostate, melanoma of the skin, and others.

Lymph node ratio predicts disease-specific survival in melanoma patients.

PubMed

Xing, Yan; Badgwell, Brian D; Ross, Merrick I; Gershenwald, Jeffrey E; Lee, Jeffrey E; Mansfield, Paul F; Lucci, Anthony; Cormier, Janice N

2009-06-01

The objectives of this analysis were to compare various measures associated with lymph node (LN) dissection and to identify threshold values associated with disease-specific survival (DSS) outcomes in patients with melanoma. Patients with lymph node-positive melanoma who underwent therapeutic LN dissection of the neck, axilla, and inguinal region were identified from the SEER database (1988-2005). We performed Cox multivariate analyses to determine the impact of the total number of LNs removed, number of negative LNs removed, and LN ratio on DSS. Multivariate cut-point analyses were conducted for each anatomic region to identify the threshold values associated with the largest improvement in DSS. The LN ratio was significantly associated with DSS for all LN regions. The LN ratio thresholds resulting in the greatest difference in 5-year DSS were .07, .13, and .18 for neck, axillary, and inguinal regions, respectively, corresponding to 15, 8, and 6 LNs removed per positive lymph node. After adjustment for other clinicopathologic factors, the hazard ratios (HRs) were .53 (95% confidence interval [CI], .40 to .71) in the neck, .52 (95% CI, .42 to .65) in the axillary, and .47 (95% CI, .36 to .61) in the inguinal regions for patients who met the LN ratio threshold. Among the prognostic factors examined, LN ratio was the best indicator of the extent of LN dissection, regardless of anatomic nodal region. These data provide evidence-based guidelines for defining adequate LN dissections in melanoma patients. (c) 2009 American Cancer Society.

Validation of a gastric cancer nomogram using a cancer registry.

PubMed

Ashfaq, Awais; Kidwell, John T; McGhan, Lee J; Dueck, Amylou C; Pockaj, Barbara A; Gray, Richard J; Bagaria, Sanjay P; Wasif, Nabil

2015-09-01

A Memorial Sloan Kettering (MSKCC) nomogram predicts disease specific survival (DSS) for gastric adenocarcinoma. The goal of this study is to use a cancer registry to compare nomogram predicted survival with actual survival in the general population. All patients undergoing surgery for gastric adenocarcinoma from the Surveillance, Epidemiology, and End Results (SEER) database (1988-2012) were studied. 6954 patients were identified. Majority of cancers were in the antrum (30.2%), and had intestinal histology (73.7%). Median follow-up was 8.2 years. Five year DSS for nomogram risk groups (0-25%, 26-50%, 51-75%, and 76-100%) was 23%, 48%, 57%, and 81% respectively. Actual DSS was 7-15% lower than nomogram predicted DSS. Relative to patients in the 76-100% 5-year DSS risk group, patients in the 0-25%, 26-50%, and 51-75% groups had significantly higher risks of death with hazard ratios of 6.84 (95%CI 6.12-7.65), 3.30 (95%CI 2.83-3.86), and 2.64 (95%CI 2.30-3.03), respectively (all P < 0.001). The concordance index for 5-year nomogram predicted DSS was 0.68 (95%CI 0.67-0.69). The MSKCC gastric cancer nomogram over-estimates DSS from gastric cancer in the general population and has a moderate concordance index. Predictive tools generated at specialized institutions may not perform as well in the general population. © 2015 Wiley Periodicals, Inc.

The Impact of Race in Male Breast Cancer Treatment and Outcome in the United States: A Population-Based Analysis of 4,279 Patients

PubMed Central

Shin, Jacob Y.; Kachnic, Lisa A.; Hirsch, Ariel E.

2014-01-01

The purpose of this study is to compare the racial differences in treatment and overall survival (OS) of male breast cancer (MBC) patients. Data were extracted from the NCI SEER database that included population-based registries from 1988 to 2010 and analyzed using SPSS 20.0. 4,279 MBC patients were identified. 3,266 (76.3%) patients were White, 552 (12.9%) Black, 246 (5.7%) Hispanic, and 215 (5.0%) Asian. Black patients were more likely to be diagnosed at younger age (P < 0.001), have advanced stage disease (P = 0.001), and be unmarried (P < 0.001) and less likely to undergo lymph node dissection (P = 0.006). When stratified by stage, there was no difference in receipt of primary treatment by race. The 5-year OS for White, Black, Hispanic, and Asian races was 73.8%, 66.3%, 74.0%, and 85.3% (P < 0.001). This significant worse 5-year OS for Blacks persisted regardless of age, stage II or III disease, and grade 2 or 3 disease. On multivariate analysis, Black race was a significant independent prognostic factor for worse OS. Blacks were less likely to receive lymph node dissection of which patients may derive benefit, though we did not observe receipt of primary treatment, after stratifying for disease stage, to be an underlying factor contributing to racial outcome differences. PMID:25349739

Dynamism or Disorder at High Pressures?

NASA Astrophysics Data System (ADS)

Angel, R. J.; Bismayer, U.; Marshall, W. G.

2002-12-01

Phase transitions in minerals at elevated temperatures typically involve dynamics as a natural consequence of the increase in thermal energy available to the system. Classic examples include quartz, cristobalite, and carbonates in which the high-temperature, high symmetry phase is dynamically disordered. This disorder has important thermodynamic consequences, including displacement and curvature of phase boundaries (e.g. calcite-aragonite). In other minerals such as clinopyroxenes and anorthite feldspar, the dynamic behaviour is restricted to the neighbourhood of the phase transition. The fundamental question is whether increasing pressure generally suppresses such dynamic behaviour (as in anorthite; Angel, 1988), or not. In the latter case it must be included in thermodynamic models of high-pressure phase equilibria and seismological modelling of the mantle; the potential dynamics and softening in stishovite may provide the critical observational constraint on the presence or otherwise of free silica in the lower mantle. We have continued to use the lead phosphate as a prototype ferroelastic in which to understand dynamic behaviour, simply because its dynamics and transition behaviour is far better characterised than any mineral. Furthermore, the phase transition is at a pressure where experimental difficulties do not dominate the experimental results. Our previous neutron diffraction study (Angel et al., 2001) revealed that some disorder, either dynamic or static, is retained in the high-symmetry, high-pressure phase just above the phase transition. New neutron diffraction data on the pure material now suggests that this disorder slowly decreases with increasing pressure until at twice the transition pressure it is ordered. Further data for doped material provides insights into the nature of this disorder. Angel (1988) Amer. Mineral. 73:1114. Angel et al (2001) J PhysC 13: 5353.

Triangle area water supply monitoring project, October 1988 through September 2001, North Carolina -- description of the water-quality network, sampling and analysis methods, and quality-assurance practices

USGS Publications Warehouse

Oblinger, Carolyn J.

2004-01-01

The Triangle Area Water Supply Monitoring Project was initiated in October 1988 to provide long-term water-quality data for six area water-supply reservoirs and their tributaries. In addition, the project provides data that can be used to determine the effectiveness of large-scale changes in water-resource management practices, document differences in water quality among water-supply types (large multiuse reservoir, small reservoir, run-of-river), and tributary-loading and in-lake data for water-quality modeling of Falls and Jordan Lakes. By September 2001, the project had progressed in four phases and included as many as 34 sites (in 1991). Most sites were sampled and analyzed by the U.S. Geological Survey. Some sites were already a part of the North Carolina Division of Water Quality statewide ambient water-quality monitoring network and were sampled by the Division of Water Quality. The network has provided data on streamflow, physical properties, and concentrations of nutrients, major ions, metals, trace elements, chlorophyll, total organic carbon, suspended sediment, and selected synthetic organic compounds. Project quality-assurance activities include written procedures for sample collection, record management and archive, collection of field quality-control samples (blank samples and replicate samples), and monitoring the quality of field supplies. In addition to project quality-assurance activities, the quality of laboratory analyses was assessed through laboratory quality-assurance practices and an independent laboratory quality-control assessment provided by the U.S. Geological Survey Branch of Quality Systems through the Blind Inorganic Sample Project and the Organic Blind Sample Project.

Time series analysis of cholera in Matlab, Bangladesh, during 1988-2001.

PubMed

Ali, Mohammad; Kim, Deok Ryun; Yunus, Mohammad; Emch, Michael

2013-03-01

The study examined the impact of in-situ climatic and marine environmental variability on cholera incidence in an endemic area of Bangladesh and developed a forecasting model for understanding the magnitude of incidence. Diarrhoea surveillance data collected between 1988 and 2001 were obtained from a field research site in Matlab, Bangladesh. Cholera cases were defined as Vibrio cholerae O1 isolated from faecal specimens of patients who sought care at treatment centres serving the Matlab population. Cholera incidence for 168 months was correlated with remotely-sensed sea-surface temperature (SST) and in-situ environmental data, including rainfall and ambient temperature. A seasonal autoregressive integrated moving average (SARIMA) model was used for determining the impact of climatic and environmental variability on cholera incidence and evaluating the ability of the model to forecast the magnitude of cholera. There were 4,157 cholera cases during the study period, with an average of 1.4 cases per 1,000 people. Since monthly cholera cases varied significantly by month, it was necessary to stabilize the variance of cholera incidence by computing the natural logarithm to conduct the analysis. The SARIMA model shows temporal clustering of cholera at one- and 12-month lags. There was a 6% increase in cholera incidence with a minimum temperature increase of one degree celsius in the current month. For increase of SST by one degree celsius, there was a 25% increase in the cholera incidence at currrent month and 18% increase in the cholera incidence at two months. Rainfall did not influenc to cause variation in cholera incidence during the study period. The model forecast the fluctuation of cholera incidence in Matlab reasonably well (Root mean square error, RMSE: 0.108). Thus, the ambient and sea-surface temperature-based model could be used in forecasting cholera outbreaks in Matlab.

Evaluation of the 1987-1988 EIA Remedial and Compensatory Program.

ERIC Educational Resources Information Center

South Carolina State Dept. of Education, Columbia. Office of Research.

Evaluation of South Carolina's 1987-88 Remedial and Compensatory Program, funded by the state's Education Improvement Act of 1984 (EIA), shows that the program was successful in raising the participants' achievement. The programs include basic skills learning in reading and mathematics in all grades, and writing in grades 6-12, but not all grades…

Bilingual Specialized Programs in New York City High Schools, 1988-89. OREA Evaluation Section Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Stern, Lucia

The Bilingual Specialized Programs in New York City High Schools project was supported by tax-levy, Pupils with Compensatory Educational Needs, and state Categorical Aid to Bilingual Education funds. The program functioned in 15 high schools in Manhattan, Brooklyn, and Queens. The program's aim was to provide students of limited English…

The Bilingual Academic Services and Integrated Career Systems Program: Project BASICS, 1987-1988. OREA Report.

ERIC Educational Resources Information Center

Berney, Tomi D.; Carey, Cecilia

The Bilingual Academic Services and Integrated Career Systems Program (Project BASICS) is a federally-funded program of instructional and support services provided to 122 students at a Queens high school. The program's aim was to develop English literacy skills and appreciation of cultural diversity, and to prepare students for the psychosocial…

Education Consolidation and Improvement Act--Chapter 1: Final Evaluation Report, Neglected and Delinquent Program.

ERIC Educational Resources Information Center

Chamberlain, Ed

This report recommends that the Neglected and Delinquent (ND) Program of the Columbus (Ohio) Public Schools, funded by the Education Consolidation and Improvement Act Chapter 1, be continued in the 1988-89 school year because the program provides a needed service to pupils in exceptional circumstances. The ND Program is designed to provide…

Report on the Educational Partnership Program, 2001-2007

ERIC Educational Resources Information Center

National Oceanic and Atmospheric Administration, 2008

2008-01-01

From the first planning meeting in December 1997, to the first grant awards made in 2001, the educational programs and training activities of the Educational Partnership Program at the National Oceanic and Atmospheric Administration (NOAA) have inspired and challenged many people to employ new and better ways to train and develop next generation…

Temporal trends of young-of-year fishes in Lake Erie and comparison of diel sampling periods

USGS Publications Warehouse

Stapanian, M.A.; Bur, M.T.; Adams, J.V.

2007-01-01

We explored temporal trends of young-of-year (YOY) fishes caught in bottom trawl hauls at an established offshore monitoring site in Lake Erie in fall during 1961–2001. Sampling was conducted during morning, afternoon, and night in each year. Catches per hour (CPH) of alewife (Alosa pseudoharengus) YOY were relatively low and exhibited no temporal trend. This result was consistent with the species’ intolerance to Lake Erie’s adverse winter water temperatures. Gizzard shad (Dorosoma cepedianum) YOY decreased sharply after 1991, which was consistent with recent oligotrophication of the lake. Following the establishment in 1979 and rapid increase of white perch (Morone americana) YOY, white bass (Morone chrysops) and freshwater drum (Aplodinotus grunniens) YOY decreased. Trout-perch (Percopsis omiscomaycus) YOY decreased during 1986–1991, but recovered to previous levels during 1991–2001. The recovery coincided with the resurgence of mayflies (Ephemoptera) in the lake. CPH of spottail shiner (Notropis hudsonius) and emerald shiner (N. atherinoides) YOY exhibited no temporal trend between 1961 and the late 1970s to early 1980s. CPH of yellow perch (Perca flavescens) YOY decreased during 1961–1988, and walleye (Sander vitreum) YOY increased overall during the time series. These observations were consistent with published studies of adults in the region. CPH of 4 of the 10 species of YOY considered were greatest during night. CPH for walleye YOY was higher in the morning than in the afternoon, but there was no significant difference between night and morning abundances. The results suggest that (1) CPH of YOY fishes may be a useful monitoring tool for Lake Erie, and (2) offshore monitoring programs that do not include night sampling periods may underestimate recruitment for several common species.

Fetal death and reduced birth rates associated with exposure to lead-contaminated drinking water.

PubMed

Edwards, Marc

2014-01-01

This ecologic study notes that fetal death rates (FDR) during the Washington DC drinking water "lead crisis" (2000-2004) peaked in 2001 when water lead levels (WLLs) were highest, and were minimized in 2004 after public health interventions were implemented to protect pregnant women. Changes in the DC FDR vs neighboring Baltimore City were correlated to DC WLL (R(2) = 0.72). Birth rates in DC also increased versus Baltimore City and versus the United States in 2004-2006, when consumers were protected from high WLLs. The increased births in DC neighborhoods comparing 2004 versus 2001 was correlated to the incidence of lead pipes (R(2) = 0.60). DC birth rates from 1999 to 2007 correlated with proxies for maternal blood lead including the geometric mean blood lead in DC children (R(2) = 0.68) and the incidence of lead poisoning in children under age 1.3 years (R(2) = 0.64). After public health protections were removed in 2006, DC FDR spiked in 2007-2009 versus 2004-2006 (p < 0.05), in a manner consistent with high WLL health risks to consumers arising from partial lead service line replacements, and DC FDR dropped to historically low levels in 2010-2011 after consumers were protected and the PSLR program was terminated. Re-evaluation of a historic construction-related miscarriage cluster in the USA Today Building (1987-1988), demonstrates that high WLLs from disturbed plumbing were a possible cause. Overall results are consistent with prior research linking increased lead exposure to higher incidence of miscarriages and fetal death, even at blood lead elevations (≈5 μg/dL) once considered relatively low.