Science.gov

Sample records for seis anos estudo

  1. SEI: An update

    NASA Technical Reports Server (NTRS)

    Peach, Lewis L., Jr.

    1991-01-01

    An update on the Space Exploration Initiative (SEI) is given in viewgraph form. Topics covered include the key prerequisites of human exploration, project planning, Mars and lunar explorations, supporting technologies, near-term strategies for SEI, human support elements, and Space Station Freedom SEI accommodations.

  2. SEI Approach to Harmonization

    DTIC Science & Technology

    2008-07-18

    technologies © 2008 Carnegie Mellon University Harmonization: Multimodel Improvement in Practice 5 SEI Webinar Series Competition for implementation resources...4 and 5 ...‖ • ―[6S]... an enabler for measuring the value of... improvements‖ • ―Six Sigma provides a way to connect process improvement and...business value‖ • ―..conducting Level 5 SCAMPI appraisals in 5 -6 days…‖ Raytheon • CMMI + R6S + IPDS + DFSS • Escaping defects from 6/KSLOC to 1.16/KSLOC

  3. Third SEI Technical Interchange: Proceedings

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Given here are the proceedings of the 3rd Space Exploration Initiative (SEI) Technical Interchange. Topics covered include the First Lunar Outpost (FLO), the Lunar Resource Mapper, lunar rovers, lunar habitat concepts, lunar shelter construction analysis, thermoelectric nuclear power systems for SEI, cryogenic storage, a space network for lunar communications, the moon as a solar power satellite, and off-the-shelf avionics for future SEI missions.

  4. SeisCORK Meeting Report

    DTIC Science & Technology

    2006-02-01

    microbiological sampling) on a single CORK (Circulation Obviation Retrofit Kit) system [ Davis et al., 1992; Jannasch el al., 2003; Shipboard Scientific...Shiboard Scie tif gic Party 04) Sir For2B SeisCORK Meeting Report WHOI-01-2006 Appendix A: Meeting Participants Tom Pettigrew, P.E. Fred Spiess Staff...Expedition 301 benefits from operational and scientific achievements from Ocean Drilling Program (ODP) Leg 168 [ Davis et al., 1997], which focused on

  5. The GEMS-2 SEIS Experiment

    NASA Astrophysics Data System (ADS)

    Tillier, S.; De Raucourt, S.; Mimoun, D.; Lognonne, P.; Giardini, D.; Christensen, U. R.; Pike, W. T.; Banerdt, B.; Laudet, P.; Kerjean, L.; Hurst, K. J.; Zweifel, P.; Mance, D.; Roll, R.; Bierwirth, M.; Gagnepain-Beyneix, J.; Nibut, T.; Robert, O.; Gabsi, T.; Pot, O.; Lecomte, B.; Schibler, P.; Mocquet, A.; Garcia, R.

    2011-12-01

    The SEIS experiment is the primary payload of the Geophysical Monitoring Station (GEMS) Mission Proposal, submitted to NASA in the frame of the 2010 Discovery program, and recently selected for the phase A study. The objective of the GEMS SEIS experiment is the determination of the deep internal structure of Mars. In particular, geophysical parameters of first importance, such as the state (liquid/solid) and size of the core, as well as structure of the mantle and shape of discontinuities will be determined by the experiment. It will measure seismic activity in a very broad band of signal, from the tidal frequencies (0.05 mHz) up to the short period frequencies (50 Hz), to address the widest range of scientific questions, from the state of the inner core to the meteoritic rate measurement. Infrasound, which might be associated to dust devils and atmospheric discharge, will be also monitored. The instrument integrates a Very Broad Band (VBB) 3 axis seismometer, completed by another trihedron of MEMS short period seismometers, environmental sensors for pressure, wind and temperature, and an infrasound sensor is additionally considered. The sensors will be deployed on the Martian ground by a robotic arm from the Phoenix lander platform and protected by a wind and thermal shield. The sensor assembly, which contains all seismic sensors, the leveling system, as well as house-keeping and temperature measurements, will be deployed on the soil in order to allow the best possible mechanical coupling with the ground motion. Thanks to the wind and thermal shield, together with the sensors' specific containers (vacuum sphere for VBBs), long term VBB bias will be protected from both temperature and pressure variations (as well as passively compensated), allowing the sensor to operate in the rough Martian thermal environment. A dedicated electronics will manage the overall experiment and ultra-low noise, space qualified 24 bits A/D converters will perform the acquisition. The

  6. The GEMS-2 Seis Experiment

    NASA Astrophysics Data System (ADS)

    Mimoun, D.; de Raucourt, S.; Lognonne, P.; Giardini, D.; Christensen, U. R.; Gagnepain-Beyneix, J.; Pike, T.; Nebut, T.; Tillier, S.; Robert, O.; Gabsi, T.; Pot, O.; Lecomte, B.; Escande, N.; Mocquet, A.; Zweifel, P.; Mance, D.; Roll, R.; Bierwirth, M.

    2010-12-01

    The objective of the Mars SEIS experiment is the determination of the deep internal structure of Mars. In particular, geophysical parameters of first importance, such as the state (liquid/solid) and size of the core, as far as structure of the mantle and shape of discontinuities will be determined by the experience. It will measure seismic activity in a very broad band of signal, from the tidal frequencies (0.05 mHz) up to the short period frequencies (50 Hz), to address the widest range of scientific questions, from the state of the inner core to the meteoritic rate measurement. The instrument integrates a Very Broad Band 3 axis seismometer, completed by another trihedron of MEMS short period seismometers, and environmental sensors for pressure, wind and temperature. The sensors will be deployed on the Martian ground by a robotic arm and protected by a wind and thermal shield. Long term VBB bias will be protected from both temperature and pressure variations (as well as passively compensated), allowing the sensor to operate in the rough Martian thermal environment. The sensor assembly, which contains all seismic sensors, as well as house-keeping and temperature measurements, will be deployed on the ground, in order to allow the best possible mechanical coupling. Infrasound, which might be associated to dust devils and atmospheric discharge, will be also monitored. The overall mass of the SEIS instrument is about 6 kg, including all sensors, data control processors and installation devices. A dedicated electronics will manage the overall experiment and ultra-low noise, space qualified 24 bits A/D converters will perform the acquisition. The instrument operation is designed to be very simple. It will operate in a “deploy and forget” strategy (with a deployment and closely monitored during the first month however) uploading data and events of interests at each pass of the relay satellite. When relay is not available, the data will be stored on-board. The upload

  7. Shizuko Sei, MD | Division of Cancer Prevention

    Cancer.gov

    Dr. Shizuko Sei (formerly Shizuko Aoki) is a medical officer with over 27 years of translational and clinical research experience in the field of cancer and AIDS. After completing her pediatric oncology fellowship at NCI Center for Cancer Research (CCR), she held various positions in the CCR and Division of Cancer Treatment and Diagnosis (DCTD) before joining the DCP in July 2015. |

  8. Draft SEI Program Plans: 1994-1998

    DTIC Science & Technology

    1993-08-01

    analyzed within a specific area of knowledge and experience. The SEI has developed a feature-oriented domain analysis ( FODA ) method that develops a...Computer Resources Support Improvement Program FAA Federal Aviation Administration FFRDC federally funded research and development center FODA feature

  9. Fall 2014 SEI Research Review: Malware Analysis

    DTIC Science & Technology

    2014-10-29

    better automation to understand the threat. • Automated static analysis of artifacts • Large-scale analysis of indicators 5 Fall 2014 SEI Research...Review J. Spring; October 29, 2014 © 2014 Carnegie Mellon University Malware Analysis Process Artifact Catalog DoD Malware Static Analysis...2014 Carnegie Mellon University Static Analysis Improvements 1. Compiler transformation framework • ROSE [Quinlan 2000] • Well-established program

  10. SEIS Experiment for the INSIGHT Mission: Towards 2018 Launch

    NASA Astrophysics Data System (ADS)

    Verdier, N.; Lognonné, P.; Banerdt, W. B.; De Raucourt, S.; IJpelaan, F.; Jerjean, L.; Pont, G.; Sylvestre-Baron, A.; Laudet, P.; Bousquet, P.; Hohhman, T.; Umland, J.; Bone, B.; Hurst, K.; Giardini, D.; Zweifel, P.; Bramanti, C.; Pike, W. T.; Calcutt, S.; Mimoun, D.; Bierwirth, M.; Christensen, U.

    2016-10-01

    After giving an outline of the InSight mission, with a focus on SEIS activities on Mars, we will describe the SEIS instrument and its performances, and provide a status of its development at the time of the workshop.

  11. Prototype Tool Support for SEI Process and Risk Knowledge

    NASA Technical Reports Server (NTRS)

    Feather, M.; Kelly, J.; Kiper, J.

    1999-01-01

    We have developed a prototype of tool support for risk assessment that uses selected components of the Software Engineering Institute (SEI) information, specifically: Capability Maturity Model (CMM) process activities, CMM process goals and the SEI taxonomy of software project risks.

  12. The SEIS Experiment: A Mars Seismic Package

    NASA Technical Reports Server (NTRS)

    Schibler, P.; Lognonne, P.; Giardini, D.; Banerdt, B.; Karczewski, J. F.; Mimoun, D.; Zweifel, P.; Pike, T.; Ammann, J.; Anglade, A.

    2003-01-01

    This experiment will integrate a VBB (Very Broad Band) two axis seismometer, a three axis Short Period seismometer and a series of environmental sensors for pressure, infra-sounds and temperature. IPGP (France) has the overall responsibility of the experiment and is responsible for the VBB and environmental sensors. ETHZ (Switzerland) is responsible for the electronics of the experiment and JPL (USA) for the SP (Short Period) sensors. SEIS instrument was first proposed and accepted for NetLander mission (and will also be in charge of data acquisition for SPICE experiment). This seismic package should also be proposed for future missions.

  13. Future needs for space robots for SEI

    NASA Astrophysics Data System (ADS)

    Erickson, Jon D.; Price, Charles R.; Cooke, Don

    1992-03-01

    Recent studies of the types, numbers, and roles of robotic systems for use in the Space Exploration Initiative (SEI), with a focus on planet surface systems (PSS), are summarized in this paper. These high-level systems' engineering, modeling, and analysis activities have supported trade studies and development of preliminary requirements for intelligent systems including supervised autonomous robotic systems. The analyses are summarized, results presented, and conclusions and recommendations are made. One conclusion is that SEI will be `enabled' by the use of supervised intelligent systems on the planet surfaces. These intelligent systems include capabilities for control and monitoring of all elements including supervised autonomous robotic systems. With the proper level of intelligent systems, the number and skills of humans on the planet surface will be determined predominantly by surface science and technology (not outpost) objectives and requirements. A broad range of robotic system uses in Earth orbit or during space transport are indicated by current studies. These include assembly of very large spacecraft systems such as propulsion systems and aerobraking structures. Maintenance is another robotic system use being studied. The differences in requirements for these and other space robotic systems compared to current industrial robotic systems are presented. Improvements in safety, reliability, and maintainability for these remote systems are stressed. Space robotics, especially those systems being developed to operate on planetary surfaces, can be considered a form of the emerging technology of field robotics on Earth. The solutions to the problems we will be solving to make the exploration of our solar system possible and practical will apply to the many problems we have which require operating in hazardous environments on Earth and to critically improving human productivity in many fields.

  14. Conducting SEI (Software Engineering Institute)-Assisted Software Process Assessments

    DTIC Science & Technology

    1989-02-01

    Agresti, W.W., "Applying Industrial Engineering to the Software Development Process," Proceedings, IEEE Fall COMPCON, Washington, DC: IEEE Com- puter...information. CMU/SEI-89-TR-7 1.2. Software Process Maturity Framework A software process maturity framework was developed by the SEI for two purposes : to pro...training. The purpose of this briefing is to give SEI team members a good understanding of the organization and the types of software it develops . Typical

  15. Fall 2014 SEI Research Review: Aligining Acquisition Strategy and Software Architecture

    DTIC Science & Technology

    2014-10-01

    CMU /SEI-2010-TN-018: “Relating Business Goals to Architecturally Significant Requirements for Software Systems“ 8 Fall 2014 SEI Research Review...occur for a given AQA  Created acquisition strategy tactics associated with AQAs *Results published in SEI TN CMU /SEI-2013-TN-026: “Results in...published in SEI TN CMU /SEI-2014-TN-019: “A Method for Aligning Acquisition Strategies and Software Architectures“ 12 Fall 2014 SEI Research Review

  16. ANO1 — EDRN Public Portal

    Cancer.gov

    ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.

  17. Evaluation of the SEI using a multilayer spectroscopic ellipsometry model

    DOE PAGES

    Dufek, Eric J.

    2014-08-28

    A multilayer spectroscopic ellipsometry (SE) model has been developed to characterize SEI formation. The model, which consists of two Cauchy layers, is constructed with an inner layer meant to model primarily inorganic compounds adjacent to an electrode and an outer layer which mirrors polymeric, organic constituents on the exterior of the SEI. Comparison of 1:1 EC:EMC and 1:4 EC:EMC with 1.0 M LiPF₆ shows distinct differences in the two modeled layers. The data suggest that the thickness of both layers change over a wide potential range. These changes have been linked with other reports on the growth of the SEI.

  18. The SEI facility for fluid-bed wood gasification

    SciTech Connect

    Bullpitt, W.S.; Rittenhouse, O.C. ); Masterson, L.D. )

    1989-09-01

    In mid 1985, construction was begun on the world's largest fluidized bed, wood gasification plant at the clay processing plant in Quincy, Fla. In March 1986, the plant was purchased by Southern Electric International (SEI). This paper describes how SEI coordinated the redesign of many of the plant systems and supervised the completion of construction and startup. In late 1986, the gasifier plant was sold. SEI remains involved as the operations and maintenance contractor on-site and is now responsible for design changes and equipment maintenance.

  19. Fall 2014 SEI Research Review High Confidence Cyber Physical Systems

    DTIC Science & Technology

    2014-10-28

    Initial Condition, Time bound Result 1: Improved SMC by Combining Over and Under Approximations REK Result 2: Improved Sequentialization by Using...Memory Consistency Rles 24 Fall 2014 SEI Research Review de Niz Oct 28th, 2014 © 2014 Carnegie Mellon University Task 2: Improved Software...Univt•r·sity 25 Fall 2014 SEI Research Review de Niz Oct 28th, 2014 © 2014 Carnegie Mellon University Task 2: Improved Software Model Checking

  20. Fall 2014 SEI Research Review: Malware Distribution Networks

    DTIC Science & Technology

    2014-10-01

    University Pittsburgh, PA 15213 Team: Dr. Jose A. Morales Dr. William Casey Aaron Volkmann ( presenting ) Report Documentation Page Form...Research Review Presenter Last Name and Date © 2014 Carnegie Mellon University Copyright 2014 Carnegie Mellon University This material is based...Institute at permission@sei.cmu.edu. DM-0001740 3 Fall 2014 SEI Research Review Presenter Last Name and Date © 2014 Carnegie Mellon University

  1. 1989 SEI Report on Graduate Software Engineering Education

    DTIC Science & Technology

    1989-06-01

    Software Specification: A Framework, H. Dieter Rombach CM-17 User Interface Development, Gary Perlman CM-19 Software Requirements, John W. Brackett...reviews. Support Materials for The Software Technical Review Process Edited by John Cross, This support materials package includes materials helpful in...engineer. It discusses both written and oral communication. SEI-CM-18-1.0 CMU/SEI-89-TR-21 79 Software Requirements John Brackett, Boston

  2. Future needs for space robots for SEI. [Space Exploration Initiative

    NASA Technical Reports Server (NTRS)

    Erickson, Jon D.; Price, Charles R.; Cooke, Douglas

    1992-01-01

    High level systems engineering modeling and analysis activities for the Space Exploration Initiative (SEI) are reviewed, with emphasis on planet surface systems. Particular attention is given to SEI studies, preliminary space robotic system requirements, and usefulness of space robotic systems developed to operate on planetary surfaces on earth. It is concluded that supervised intelligent systems on the planet surfaces are necessary to make SEI planet surface activities reliable and productive and encompass capabilities for control and monitoring of all elements, including supervised autonomous robotic systems. Amplification of human capabilities due to applying more knowledge and reasoning in more flexible and appropriate ways than conventional automation approaches will provide more robust performance, greater choice of interaction modes with operators, and greater transparency of operation.

  3. The Mars SEIS Experiment: A Mars Seismic Package

    NASA Technical Reports Server (NTRS)

    Mimoun, D.; Lognonne, P.; Banerdt, W. B.; Schibler, P.; Giardini, D.; Pont, G.

    2005-01-01

    The Mars SEIS experiment. The SEIS experiment was first proposed by IPGP (and accepted) for the NetLander mission. It integrates two VBB (Very Broad Band) seismometers, a three axis Short Period seismometer and a series of environmental sensors for pressure, infra-sounds and temperature. IPGP (France) has the overall responsibility of the experiment and is responsible for the seismic and environmental sensors. ETHZ (Switzerland) is responsible for the electronics of the experiment and JPL (USA) for the SP (Short Period) sensors. As NetLander mission has been cancelled (while fortunately the development still goes on), this seismic package can be proposed for future Mars missions.

  4. 76 FR 72729 - SEI Investments Management Corporation, et al.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION SEI Investments Management Corporation, et al. November 18, 2011. AGENCY: Securities and Exchange Commission (``Commission''). ACTION: Notice of an application under section 6(c) of the Investment...

  5. Fall 2014 SEI Research Review Insider Threat Mitigation LINE Project

    DTIC Science & Technology

    2014-10-01

    Manning Case 11/18/2014 Copywrite © 2014 Kathleen M Carley 7 Come to poster session to see detailed results and talk with analysts! 8 Fall 2014...Fall 2014 SEI Research Review Moore, 28-30 October 2014 © 2014 Carnegie Mellon University Contact Information Slide Format Presenter / Point of

  6. LispSEI: The Programmer’s Manual

    DTIC Science & Technology

    1988-01-01

    Taste ) .:( Smell ) .;(See) (defvar *TRACE-SENSE* NIL) (defvar $SOUNO-TYPE: 0) ;;Equivalent to... taste touch)) (defvar *ENTITIES* ’(object sound smell taste contact)) ;Wanked from LispSEI.l: (defvar PRIMITIVE 0) (defvar COMPLEXOBJ 1) (defvar POLYGON... smell -threshold. (dot-constraint smell -intensity-constraint ( smell -threshold) smell (> (emission-intensity entity) smell -threshol d)) ;;Only taste

  7. Robotic on-orbit fueling of SEI vehicles

    NASA Astrophysics Data System (ADS)

    Clarke, Margaret M.; Haines, David E.; Mauceri, A. J.

    Research to investigate the feasibility of, and to develop concepts for, the robotic supply of consumables on orbit is examined, with emphasis on Space Exploration Initiative (SEI) assets. Principal methods for effecting propellant transfer on orbit are summarized, and the pros and cons of applying robotics to each method are discussed. Methods include direct transfer of fuel and oxidizer, assembly of tanks to the vehicle, and assembly of propulsion modules to the vehicles. Guidelines are developed for the automated/robotic cryogenic propellant transfer mechanism to accomplish on-orbit consumable supply of SEI vehicles by direct fluid transfer. The development of initial design concepts for the LEO fueling of the Mars Transfer System is traced.

  8. MatSeis developer's guide:version 1.0.

    SciTech Connect

    McConnell, Lane Christopher; Young, Christopher John

    2007-05-01

    This guide is intended to enable researchers working with seismic data, but lacking backgrounds in computer science and programming, to develop seismic algorithms using the MATLAB-based MatSeis software. Specifically, it presents a series of step-by-step instructions to write four specific functions of increasing complexity, while simultaneously explaining the notation, syntax, and general program design of the functions being written. The ultimate goal is that that the user can use this guide as a jumping off point from which he or she can write new functions that are compatible with and expand the capabilities of the current MatSeis software that has been developed as part of the Ground-based Nuclear Explosion Monitoring Research and Engineering (GNEMRE) program at Sandia National Laboratories.

  9. The role of SEI in lithium and lithium ion batteries

    SciTech Connect

    Peled, E.; Golodnitsky, D.; Ardel, G.; Menachem, C.; Bar-Tow, D.; Eshkenazy, V.

    1995-12-31

    This paper presents and discusses fundamental processes taking place at the lithium and Li{sub x}C{sub 6} electrode/electrolyte interphases and models for these interphases. The authors deal with both nonaqueous and polymer (dry and gel) electrolytes, graphitized and nongraphitized carbonaceous materials as anodes for Li-ion batteries. Each electrode/electrolyte combination has its own unique features and problems but there are some general phenomena common to all of them. Issues to be reviewed include SEI composition, morphology and formation reactions, graphite surface modifications including chemical bonded SEI and micro channels formation, electrode degradation processes, lithium deposition-dissolution and intercalation-deintercalation mechanisms, rate-determining steps (RDS), electrolyte and electrode parameters and conditions affecting the above mentioned processes. Technology-related issues are emphasized.

  10. SEI in-space operations and support challenges

    NASA Astrophysics Data System (ADS)

    Caldwell, Ronald

    A modeling and assessment process used to integrate SEI operations and support (OAS) planning processes with the systems engineering design, and system integration disciplines. Four areas of the OAS activity require the development of large infrastructures to maintain an operational capability: earth, orbital, transorbital, and lunar/Martian surface locations. An analytical process that can be used to develop OAS requirements is illustrated. Relationships of manufacturing, prelaunch operations, and orbital operations when deriving requirements are shown. If a concurrent engineering process is used, a more operationally efficient design can be defined early in the program to support all functions. Challenges associated with SEI logistics, the necessity for using functional analyses in the development of system requirements, some candidate operational lunar or Mars systems, and analytical modeling results on the candidate designs are discussed.

  11. FAll 2014 SEI Research Review Verifying Evolving Software

    DTIC Science & Technology

    2014-10-28

    Scalable verification of evolving software • reduce re-verification effort • close semantic gap between compiler and verifier • enable safe use of... compiler optimizations in safety-critical code Related Work: Current solutions are limited by • effectiveness (syntactic slicing, regression...developed by us 5 Fall 2014 SEI Research Review Gurfinkel, October 28, 2014 © 2014 Carnegie Mellon University Model Problem: Certifying Compiler for

  12. Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells.

    PubMed

    Cherkashin, Alexander P; Kolesnikova, Alisa S; Tarasov, Michail V; Romanov, Roman A; Rogachevskaja, Olga A; Bystrova, Marina F; Kolesnikov, Stanislav S

    2016-02-01

    Specialized Ca(2+)-dependent ion channels ubiquitously couple intracellular Ca(2+) signals to a change in cell polarization. The existing physiological evidence suggests that Ca(2+)-activated Cl(-) channels (CaCCs) are functional in taste cells. Because Ano1 and Ano2 encode channel proteins that form CaCCs in a variety of cells, we analyzed their expression in mouse taste cells. Transcripts for Ano1 and Ano2 were detected in circumvallate (CV) papillae, and their expression in taste cells was confirmed using immunohistochemistry. When dialyzed with CsCl, taste cells of the type III exhibited no ion currents dependent on cytosolic Ca(2+). Large Ca(2+)-gated currents mediated by TRPM5 were elicited in type II cells by Ca(2+) uncaging. When TRPM5 was inhibited by triphenylphosphine oxide (TPPO), ionomycin stimulated a small but resolvable inward current that was eliminated by anion channel blockers, including T16Ainh-A01 (T16), a specific Ano1 antagonist. This suggests that CaCCs, including Ano1-like channels, are functional in type II cells. In type I cells, CaCCs were prominently active, blockable with the CaCC antagonist CaCCinh-A01 but insensitive to T16. By profiling Ano1 and Ano2 expressions in individual taste cells, we revealed Ano1 transcripts in type II cells only, while Ano2 transcripts were detected in both type I and type II cells. P2Y agonists stimulated Ca(2+)-gated Cl(-) currents in type I cells. Thus, CaCCs, possibly formed by Ano2, serve as effectors downstream of P2Y receptors in type I cells. While the role for TRPM5 in taste transduction is well established, the physiological significance of expression of CaCCs in type II cells remains to be elucidated.

  13. Providing Meaningful Learning for Students of the Sixth Grade of Middle School: a Study on the Moon Phases. (Breton Title: Propiciando Aprendizagem Significativa Para Alunos do Sexto Ano do Ensino Fundamental: um Estudo sobre as Fases da Lua.) Propiciando el Aprendizaje Significativo Para Alumnos del Sexto Nivel de la Educación General Básica: un Estudio sobre Las Fases de la Luna

    NASA Astrophysics Data System (ADS)

    Darroz, Luiz Marcelo; Samudio Pérez, Carlos Ariel; da Rosa, Cleci Werner; Heineck, Renato

    2012-07-01

    We relate in this article a didactic experience studying the moon phases with a group of middle school students of a private school of the municipality of Passo Fundo, RS. Based on David Ausubel's Meaningful Learning Theory, we have sought to develop a proposal following a didactic model which simulates the phases of the Moon, as based on the previous conceptions of the students. The signs of learning were evidenced by means of memory registries of the activity. From the obtained results we believe that the proposal achieved its goals, since the students were able to identify, differentiate and transfer the phenomenon of the moon phases to new contexts. Thus, it is concluded that a methodology focused on a meaningful content for the students is fundamental to the construction and genuine grasping of what is being learned. Neste artigo, relata-se uma experiência didática de estudo das fases da Lua com uma turma do 6° ano do Ensino Fundamental, de uma escola privada do município de Passo Fundo, RS. Tendo como fundamentação teórica a Teoria da Aprendizagem Significativa de David Ausubel, buscou-se desenvolver a proposta a partir de um modelo didático que simula as fases da Lua e com base nas concepções prévias dos estudantes. Os indícios da aprendizagem foram constatados através de registros de memórias da atividade. Pelos resultados apresentados, acredita-se que a proposta alcançou seus objetivos, uma vez que os estudantes conseguiram identificar, diferenciar e transferir o fenômeno das fases da Lua para novos contextos. Assim, conclui-se que uma metodologia com enfoque em um conteúdo significativo ao estudante é fundamental para a construção e compreensão genuína do que está sendo aprendido. En este artículo se relata una experiencia didáctica de estudio de las fases de la Luna con una clase de 6º año de la educación general básica de una escuela privada del municipio de Passo Fundo, RS. Teniendo como fundamentación teórica la Teor

  14. 76 FR 43985 - Endangered and Threatened Species; Recovery Plan for the Sei Whale

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ... Plan for the Sei Whale AGENCY: National Marine Fisheries Service, National Oceanic and Atmospheric... the sei whale (Balaenoptera borealis). NMFS is soliciting review and comment from the public and all... would not promote its recovery. The sei whale has been listed as ``endangered'' under the...

  15. 77 FR 5491 - Endangered and Threatened Species; Initiation of 5-Year Review for Sei Whales

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ...; Initiation of 5-Year Review for Sei Whales AGENCY: National Marine Fisheries Service (NMFS), National Oceanic...; request for information. SUMMARY: NMFS announces a 5-year review of sei whales (Balaenoptera borealis... of any such information on sei whales that has become available since that has become available...

  16. SEI Report on Graduate Software Engineering Education for 1991

    DTIC Science & Technology

    1991-04-01

    be exemplified by the case of the Therac - 25 therapeutic radiation machine. The machine evolved from earlier designs, with hardware func- tion being...Curriculum Topic Index 17 2.6. Curriculum Design 21 2.7. Project Experience Component 21 2.8. Electives 25 2.9. Pedagogical Considerations 25 2.10. The...advanced programming. CMU/SEI-91-TR-2 25 2.8. Electives Electives may comprise 20% to 40% of a curriculum. Although software engineering is a young

  17. Communications system evolutionary scenarios for Martian SEI support

    NASA Technical Reports Server (NTRS)

    Kwong, Paulman W.; Bruno, Ronald C.

    1992-01-01

    In the Space Exploration Initiative (SEI) mission scenarios, expanding human presence is the primary driver for high data rate Mars-Earth communications. To support an expanding human presence, the data rate requirement will be gradual, following the phased implementation over time of the evolving SEI mission. Similarly, the growth and evolution of the space communications infrastructure to serve this requirement will also be gradual to efficiently exploit the useful life of the installed communications infrastructure and to ensure backward compatibility with long-term users. In work conducted over the past year, a number of alternatives for supporting high data rate Mars-Earth communications have been analyzed with respect to their compatibility with gradual evolution of the space communications infrastructure. The alternatives include RF, millimeter wave (MMW), and optical implementations, and incorporate both surface and space-based relay terminals in the Mars and Earth regions. Each alternative is evaluated with respect to its ability to efficiently meet a projected growth in data rate over time, its technology readiness, and its capability to satisfy the key conditions and constraints imposed by evolutionary transition. As a result of this analysis, a set of attractive alternative communications architectures have been identified and described, and a road map is developed that illustrates the most rational and beneficial evolutionary paths for the communications infrastructure.

  18. Communications system evolutionary scenarios for Martian SEI support

    NASA Astrophysics Data System (ADS)

    Kwong, Paulman W.; Bruno, Ronald C.

    1992-02-01

    In the Space Exploration Initiative (SEI) mission scenarios, expanding human presence is the primary driver for high data rate Mars-Earth communications. To support an expanding human presence, the data rate requirement will be gradual, following the phased implementation over time of the evolving SEI mission. Similarly, the growth and evolution of the space communications infrastructure to serve this requirement will also be gradual to efficiently exploit the useful life of the installed communications infrastructure and to ensure backward compatibility with long-term users. In work conducted over the past year, a number of alternatives for supporting high data rate Mars-Earth communications have been analyzed with respect to their compatibility with gradual evolution of the space communications infrastructure. The alternatives include RF, millimeter wave (MMW), and optical implementations, and incorporate both surface and space-based relay terminals in the Mars and Earth regions. Each alternative is evaluated with respect to its ability to efficiently meet a projected growth in data rate over time, its technology readiness, and its capability to satisfy the key conditions and constraints imposed by evolutionary transition. As a result of this analysis, a set of attractive alternative communications architectures have been identified and described, and a road map is developed that illustrates the most rational and beneficial evolutionary paths for the communications infrastructure.

  19. Low frequency vocalizations attributed to sei whales (Balaenoptera borealis).

    PubMed

    Baumgartner, Mark F; Van Parijs, Sofie M; Wenzel, Frederick W; Tremblay, Christopher J; Carter Esch, H; Warde, Ann M

    2008-08-01

    Low frequency (<100 Hz) downsweep vocalizations were repeatedly recorded from ocean gliders east of Cape Cod, MA in May 2005. To identify the species responsible for this call, arrays of acoustic recorders were deployed in this same area during 2006 and 2007. 70 h of collocated visual observations at the center of each array were used to compare the localized occurrence of this call to the occurrence of three baleen whale species: right, humpback, and sei whales. The low frequency call was significantly associated only with the occurrence of sei whales. On average, the call swept from 82 to 34 Hz over 1.4 s and was most often produced as a single call, although pairs and (more rarely) triplets were occasionally detected. Individual calls comprising the pairs were localized to within tens of meters of one another and were more similar to one another than to contemporaneous calls by other whales, suggesting that paired calls may be produced by the same animal. A synthetic kernel was developed to facilitate automatic detection of this call using spectrogram-correlation methods. The optimal kernel missed 14% of calls, and of all the calls that were automatically detected, 15% were false positives.

  20. Fall 2014 SEI Research Review: FY14-03 Software Assurance Engineering

    DTIC Science & Technology

    2014-10-28

    unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 2 Fall 2014 SEI Research Review Presenter Last Name and Date © 2014 Carnegie...service marks of Carnegie Mellon University. DM-0001767 3 Fall 2014 SEI Research Review Presenter Last Name and Date © 2014 Carnegie...2: Applying Software Quality Models to Software Assurance 4 Fall 2014 SEI Research Review Presenter Last Name and Date © 2014 Carnegie Mellon

  1. Fall 2014 SEI Research Review Value-Driven Iterative and Incremental Development

    DTIC Science & Technology

    2014-10-28

    c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 2 Fall 2014 SEI Research Review Presenter Last Name and...0001795 3 Fall 2014 SEI Research Review Presenter Last Name and Date © 2014 Carnegie Mellon University Value-Driven Incremental Development...Fall 2014 SEI Research Review Presenter Last Name and Date © 2014 Carnegie Mellon University Technical Approach Multi-dimensional Analysis Drives

  2. Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2

    PubMed Central

    Seo, Yohan; Lee, Ho K.; Park, Jinhong; Jeon, Dong-kyu; Jo, Sungwoo; Jo, Minjae; Namkung, Wan

    2016-01-01

    Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth muscle contraction, nociception and cancer progression. To date, only a few ANO1 inhibitors have been described, and these have low potency and selectivity for ANO1. Here, we performed a high-throughput screening to identify highly potent and selective small molecule inhibitors of ANO1. Three novel ANO1 inhibitors were discovered from screening of 54,400 synthetic small molecules, and they were found to fully block ANO1 channel activity with an IC50 < 3 μM. Electrophysiological analysis revealed that the most potent inhibitor, 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), completely inhibited ANO1 chloride current with submicromolar potency. Notably, unlike previous small-molecule ANO1 inhibitors identified to date, Ani9 displayed high selectivity for ANO1 as compared to ANO2, which shares a high amino acid homology to ANO1. In addition, Ani9 did not affect the intracellular calcium signaling and CFTR chloride channel activity. Our results suggest that Ani9 may be a useful pharmacological tool for studying ANO1 and a potential development candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma. PMID:27219012

  3. Ground test facility for SEI nuclear rocket engines

    SciTech Connect

    Harmon, C.D.; Ottinger, C.A.; Sanchez, L.C.; Shipers, L.R.

    1992-08-01

    Nuclear Thermal Propulsion (NTP) has been identified as a critical technology in support of the NASA Space Exploration Initiative (SEI). In order to safely develop a reliable, reusable, long-lived flight engine, facilities are required that will support ground tests to qualify the nuclear rocket engine design. Initial nuclear fuel element testing will need to be performed in a facility that supports a realistic thermal and neutronic environment in which the fuel elements will operate at a fraction of the power of a flight weight reactor/engine. Ground testing of nuclear rocket engines is not new. New restrictions mandated by the National Environmental Protection Act of 1970, however, now require major changes to be made in the manner in which reactor engines are now tested. These new restrictions now preclude the types of nuclear rocket engine tests that were performed in the past from being done today. A major attribute of a safely operating ground test facility is its ability to prevent fission products from being released in appreciable amounts to the environment. Details of the intricacies and complications involved with the design of a fuel element ground test facility are presented in this report with a strong emphasis on safety and economy.

  4. 75 FR 39916 - Endangered and Threatened Species; Notice of Intent to Prepare a Recovery Plan for the Sei Whale

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... Intent to Prepare a Recovery Plan for the Sei Whale AGENCY: National Marine Fisheries Service (NMFS... its intent to prepare a recovery plan for the Sei Whale (Balaenoptera borealis) and requests... ``Sei Whale Recovery Plan Information'' 3. Mail: National Marine Fisheries Service, Office of...

  5. 75 FR 65005 - Intent To Prepare a Draft Supplemental Environmental Impact Statement (SEIS), Mississippi Barrier...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-21

    ... Statement (SEIS), Mississippi Barrier Island Restoration, Mississippi Coastal Improvements Program (MsCIP... comprehensive restoration of the Mississippi barrier islands. These actions are related to the consequences of... and wildlife, prevention of erosion, barrier island restoration, and other related water...

  6. Fall 2014 SEI Research Review Contract-Based Integration of CPS Analyses

    DTIC Science & Technology

    2014-10-28

    2014 Carnegie Mellon University Fall 2014 SEI Research Review Contract-Based Integration of CPS Analyses Software Engineering Institute...DATE 28 OCT 2014 2. REPORT TYPE N/A 3. DATES COVERED 4. TITLE AND SUBTITLE Contract-Based Integration of CPS Analyses - SEI Research Review...etc. Large CPS are integrated out of components developed by suppliers that use their own analysis methods and make their own assumptions

  7. SEI (Software Engineering Institute) Report on Graduate Software Engineering Education, 1989

    DTIC Science & Technology

    1989-06-01

    Framework, H. Dieter Rombach CM-17 User Interface Development, Gary Perlman CM-19 Software Requirements, John W. Brackett Pedagogical Concerns Case...Software Technical Review Process Edited by John Cross, This support materials package includes materials helpful in teach- Indiana University of ing a...communication. SEI-CM- 18-1.0 CMU/SEI-89-TR-21 79 Software Requirements • John Brackett, This curriculum module is concerned with the definition of

  8. Solid state NMR study of SEI formation in lithium ion batteries

    NASA Astrophysics Data System (ADS)

    Zhao, Dachun

    Recently, rechargeable lithium ion batteries, which offer high energy density and long cycle life, are in great demand as power sources for our mobile electronic society. The formation of a solid electrolyte interphase (SEI) on the surface of electrodes in lithium ion batteries plays an essential role in their performance. This thesis presents solid state NMR and MAS NMR results on the SEI, which contribute to our understanding of SEI formation on both cathodes and anodes. This thesis is organized as following: Chapter 1 surveys the history of batteries and the challenges to further development of the lithium ion battery. Fundamental aspects and SEI formation mechanisms are also included in Chapter l. Chapter 2 deals with the principles and experimental techniques of solid state NMR. Chapter 3 presents studies of SEI formation on anode and cathode in lithium ion batteries using electrochemical impedance spectroscopy (EIS) and NMR. The results provide EIS and NMR evidence that cells containing electrolytes with high EC content display less irreversible capacity after high temperature storage. The irreversible capacity is attributed to SEI growth on electrode surfaces. NMR results on cathodes, on the other hand, imply that the presence of Ni in the cathode may reduce cell performance due to the oxidation of Ni 3+ to Ni4+. Our simulations show that a lower EC/DMC ratio is associated with a smaller SEI intensity for the cathode and higher intensity for the anode. Chapter 4 discusses the effect of temperature on SEI formation on anodes and cathodes. NMR measurements show that MCMB graphite based anodes exhibit high stability no chemical shift is evident over a wide temperature range. On cathodes, however, NMR does reveal changes in SEI intensity as a function of temperature. These changes are believed to be the result of decomposition of the SEI. Evidently, then, changes in the performance of the cell as a factor of temperature are, at least in part, due to changes in

  9. Genomic and proteomic characterization of SE-I, a temperate bacteriophage infecting Erysipelothrix rhusiopathiae.

    PubMed

    Yuan, Wentao; Zhang, Yaning; Wang, Guangcao; Bai, Juan; Wang, Xianwei; Li, Yufeng; Jiang, Ping

    2016-11-01

    A bacteriophage infecting pathogenic Erysipelothrix rhusiopathiae was isolated from a swine farm experiencing an outbreak of acute swine erysipelas; we designated this phage SE-I. SE-I has an icosahedral head, a long tail and a double-stranded DNA genome. The 34,997-bp genome has a GC content of 34 % and contains 43 open reading frames (ORFs) encoding packaging, structural, lysin-holin, and hypothetical proteins. Components of purified SE-I were separated using SDS-PAGE and analyzed using liquid chromatography-mass spectrometry. Nine proteins were identified, encoded by ORF9, ORF15, ORF23, ORF30, ORF31, ORF33, ORF39, ORF40 and ORF 42. A phylogenetic tree constructed based on the sequence of the large terminase subunit revealed that SE-I is closely related to Staphylococcus phages P954 and phi3396. The CHAP-domain-containing protein encoded by ORF25 was expressed in E. coli and which was able to inactivate host bacteria. SE-I was able to infect 7 of 13 E. rhusiopathiae strains, but was unable to infect Salmonella, Streptococcus suis, and Staphylococcus aureus. This is the first report of the isolation, characterization, and genomic and proteomic analysis of a temperate phage infecting E. rhusiopathiae, and it might lead to the development of new anti- E. rhusiopathiae agents.

  10. Silicon nanowire degradation and stabilization during lithium cycling by SEI layer formation.

    PubMed

    Cho, Jeong-Hyun; Picraux, S Tom

    2014-06-11

    Silicon anodes are of great interest for advanced lithium-ion battery applications due to their order of magnitude higher energy capacity than graphite. Below a critical diameter, silicon nanowires enable the ∼300% volume expansion during lithiation without pulverization. However, their high surface-to-volume ratio is believed to contribute to fading of their capacity retention during cycling due to solid-electrolyte-interphase (SEI) growth on surfaces. To better understand this issue, previous studies have examined the composition and morphology of the SEI layers. Here we report direct measurements of the reduction in silicon nanowire diameter with number of cycles due to SEI formation. The results reveal significantly greater Si loss near the nanowire base. From the change in silicon volume we can accurately predict the measured specific capacity reduction for silicon nanowire half cells. The enhanced Si loss near the nanowire/metal current collector interface suggests new strategies for stabilizing nanowires for long cycle life performance.

  11. SEI power source alternatives for rovers and other multi-kWe distributed surface applications

    NASA Technical Reports Server (NTRS)

    Bents, David J.; Kohout, L. L.; Mckissock, Barbara I.; Rodriguez, C. D.; Withrow, C. A.; Colozza, A.; Hanlon, James C.; Schmitz, Paul C.

    1991-01-01

    To support the Space Exploration Initiative (SEI), a study was performed to investigate power system alternatives for the rover vehicles and servicers that were subsequently generated for each of these rovers and servicers, candidate power sources incorporating various power generation and energy storage technologies were identified. The technologies were those believed most appropriate to the SEI missions, and included solar, electrochemical, and isotope systems. The candidates were characterized with respect to system mass, deployed area, and volume. For each of the missions a preliminary selection was made. Results of this study depict the available power sources in light of mission requirements as they are currently defined.

  12. Fall 2014 SEI Research Review: Behavior Based Analysis and Detection of Mobile Malware

    DTIC Science & Technology

    2014-10-01

    Fall 2014 SEI Research Review Presenter Last Name and Date © 2014 Carnegie Mellon University Analysis Methodology - Approach •Strace Android APK ...logcat, network information, apk and signature data - can run up to 30 minutes, average around 4 minutes to complete all activities 11 Fall

  13. SeisRockHT - Seismic Rockfall Monitoring in the Hohe Tauern region

    NASA Astrophysics Data System (ADS)

    Binder, Daniel; Hartmeyer, Ingo; Keuschnig, Markus; Mertl, Stefan; Lenhardt, Wolfgang

    2016-04-01

    SeisRockHT focuses on open hardware and free software applied for scientific long-term monitoring strategies in harsh environments. In detail, SeisRockHT aims at the establishment of two seismic networks to quantitatively observe seismicity and rockfall events at high alpine north faces. Due to the rare character of rockfall events, a continuous and long-term observation strategy is targeted. The long-term perspective is assured through the project partner of the Austrian seismic service who will include SeisRockHT networks when the project is completed. Two study sites were selected for monitoring: the Kitzsteinhorn and the Hohe Sonnblick exhibiting two different scales of monitoring networks. The smaller scaled Kitzsteinhorn investigation site is closely related to bedrock permafrost processes, whereas the larger-scaled Sonnblick investigation site aims a classic alpine north face. SeisRockHT will develop a suite of optimum methods for characterization, detection and localization of the seismic events recorded at the two sites. Beside analysis of discrete seismic events, ambient seismic noise analysis promises a closer insight into rockfall precursory seismic characteristics.Based on the high quality complementary data delivered by already established long-term monitoring projects at the two sites, potential rockfall triggers will be suggested.

  14. 75 FR 54420 - Cancellation of Supplemental Environmental Impact Statement (SEIS); Travis County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    ... Statement (SEIS) would be prepared for the proposed SH 71 roadway between Riverside Drive and SH 130 in... for proposed improvements to State Highway (SH) 71 from Riverside Drive to SH 130, in Travis County... to 40 CFR 1508.22 and 43 TAC Sec. 2.5(e)(2) for proposed improvement of SH 71 from Riverside Drive...

  15. How many records should be used in ASCE/SEI-7 ground motion scaling procedure?

    USGS Publications Warehouse

    Reyes, Juan C.; Kalkan, Erol

    2012-01-01

    U.S. national building codes refer to the ASCE/SEI-7 provisions for selecting and scaling ground motions for use in nonlinear response history analysis of structures. Because the limiting values for the number of records in the ASCE/SEI-7 are based on engineering experience, this study examines the required number of records statistically, such that the scaled records provide accurate, efficient, and consistent estimates of “true” structural responses. Based on elastic–perfectly plastic and bilinear single-degree-of-freedom systems, the ASCE/SEI-7 scaling procedure is applied to 480 sets of ground motions; the number of records in these sets varies from three to ten. As compared to benchmark responses, it is demonstrated that the ASCE/SEI-7 scaling procedure is conservative if fewer than seven ground motions are employed. Utilizing seven or more randomly selected records provides more accurate estimate of the responses. Selecting records based on their spectral shape and design spectral acceleration increases the accuracy and efficiency of the procedure.

  16. Lessons learned on utilizing the SEI/CMM in the federal government work for others environment

    SciTech Connect

    Stewart, A.

    1997-11-01

    This report contains viewgraphs on lessons learned on utilizing the Software Engineering Institute Capability Maturity Model in the federal government work for others environment. These viewgraphs outline: data systems research and development; what is the SEI/CMM; Data Systems Research and Development process improvement approach; accomplishments; and lessons learned.

  17. Fall 2014 SEI Research Review Applying Agile Methods to DoD

    DTIC Science & Technology

    2014-10-28

    2014 © 2014 Carnegie Mellon University Agile Defense Adoption Proponents Team (ADAPT) member E-Learning Agile Course Multiple Presentations ... presentations , program committees: GSAW 2014, Agile 2014, Contracts in Agile International Meeting, AFEI/SEI DoD Agile Summit, GAO Working Groups 8

  18. 77 FR 40406 - Cancellation of Supplemental Environmental Impact Statement (SEIS); Travis County, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-09

    ... Highway (SH) 71 West through Oak Hill, in Travis County, Texas, is being rescinded. FOR FURTHER... of US 290/SH 71 West through Oak Hill, in Travis County, Texas. The improvements proposed between... the NOI to prepare a SEIS for US 290/SH 71 West through Oak Hill from RM 1826 to Joe Tanner Lane....

  19. Required number of records for ASCE/SEI 7 ground-motion scaling procedure

    USGS Publications Warehouse

    Reyes, Juan C.; Kalkan, Erol

    2011-01-01

    The procedures and criteria in 2006 IBC (International Council of Building Officials, 2006) and 2007 CBC (International Council of Building Officials, 2007) for the selection and scaling ground-motions for use in nonlinear response history analysis (RHA) of structures are based on ASCE/SEI 7 provisions (ASCE, 2005, 2010). According to ASCE/SEI 7, earthquake records should be selected from events of magnitudes, fault distance, and source mechanisms that comply with the maximum considered earthquake, and then scaled so that the average value of the 5-percent-damped response spectra for the set of scaled records is not less than the design response spectrum over the period range from 0.2Tn to 1.5Tn sec (where Tn is the fundamental vibration period of the structure). If at least seven ground-motions are analyzed, the design values of engineering demand parameters (EDPs) are taken as the average of the EDPs determined from the analyses. If fewer than seven ground-motions are analyzed, the design values of EDPs are taken as the maximum values of the EDPs. ASCE/SEI 7 requires a minimum of three ground-motions. These limits on the number of records in the ASCE/SEI 7 procedure are based on engineering experience, rather than on a comprehensive evaluation. This study statistically examines the required number of records for the ASCE/SEI 7 procedure, such that the scaled records provide accurate, efficient, and consistent estimates of" true" structural responses. Based on elastic-perfectly-plastic and bilinear single-degree-of-freedom systems, the ASCE/SEI 7 scaling procedure is applied to 480 sets of ground-motions. The number of records in these sets varies from three to ten. The records in each set were selected either (i) randomly, (ii) considering their spectral shapes, or (iii) considering their spectral shapes and design spectral-acceleration value, A(Tn). As compared to benchmark (that is, "true") responses from unscaled records using a larger catalog of ground

  20. A normal ano-genital exam: sexual abuse or not?

    PubMed

    Hornor, Gail

    2010-01-01

    Sexual abuse is a problem of epidemic proportions in the United States. Pediatric nurse practitioners (PNPs) are at the forefront of providing care to children and families. The PNP is in a unique position to educate patients and families regarding sexual abuse and dispel common myths associated with sexual abuse. One such myth is that a normal ano-genital examination is synonymous with the absence of sexual abuse. This article will provide primary care providers, including PNPs, with a framework for understanding why a normal ano-genital examination does not negate the possibility of sexual abuse/assault. Normal ano-genital anatomy, changes that occur with puberty, and physical properties related to the genitalia and anus will be discussed. Photos will provide visualization of both normal variants of the pre-pubertal hymen and genitalia as well as changes that occur with puberty. Implications for practice for PNPs will be discussed.

  1. 76 FR 336 - Intent To Prepare a Supplemental Environmental Impact Statement (SEIS) for PacRim Coal's Proposed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... Clean Water Act. The SEIS will be used as a basis for the Corps' permit decision and to ensure compliance with the National Environmental Policy Act (NEPA). The SEIS will also address issues related to... (71 FR 33446). On October 31, 2010, the EPA's authority to issue and enforce mining permits in...

  2. SEI Overview

    DTIC Science & Technology

    2012-06-11

    Malicious Code Detection and Analysis Techniques • Trustworthy Embedded Systems • Digital Investigations and Video Exploitation Gap Area Tools...Workshop ATAM QAW eLearning Pilots Technical Assessments QUASAR Mission Success in Complex Environments Line-Funded Exploratory New Starts (LENS...area technologies to advance the state of practice of digital exploitation and analysis. 20 Secure Software and Systems Develop and adapt

  3. SEI power source alternatives for rovers and other multi-kWe distributed surface applications

    NASA Technical Reports Server (NTRS)

    Bents, D. J.; Kohout, Lisa L.; Mckissock, B. I.; Rodriguez, C. D.; Withrow, C. A.; Colozza, A.; Hanlon, J. C.; Schmitz, P. C.

    1991-01-01

    Results of the study performed to support the Space Exploration Initiative (SEI) which investigated power system alternatives for the rover vehicles and servicers that would be used for construction and operation of a lunar base is described. Using the mission requirements and power profiles that were subsequently generated for each of these rovers and servicers, candidate power sources incorporating various power generation and energy storage technologies were identified. The technologies were those believed most appropriate to the SEI missions, and included solar, electrochemical, and isotope systems. The candidates were characterized with respect to system mass, deployed area and volume. For each of the missions a preliminary selection was made. Results of this study depict the available power sources in light of the mission requirements as they are currently defined.

  4. On the use of Space Station Freedom in support of the SEI - Life science research

    NASA Technical Reports Server (NTRS)

    Leath, K.; Volosin, J.; Cookson, S.

    1992-01-01

    The use of the Space Station Freedom (SSF) for life sciences research is evaluated from the standpoint of requirements for the Space Exploration Initiative (SEI). SEI life sciences research encompasses: (1) biological growth and development in space; (2) life support and environmental health; (3) physiological/psychological factors of extended space travel; and (4) space environmental factors. The platforms required to support useful study in these areas are listed and include ground-based facilities, permanently manned spacecraft, and the Space Shuttle. The SSF is shown to be particularly applicable to the areas of research because its facilities can permit the study of gravitational biology, life-support systems, and crew health. The SSF can serve as an experimental vehicle to derive the required knowledge needed to establish a commitment to manned Mars missions and colonization plans.

  5. Solid Electrolyte Interphase (SEI) at TiO2 Electrodes in Li-Ion Batteries: Defining Apparent and Effective SEI Based on Evidence from X-ray Photoemission Spectroscopy and Scanning Electrochemical Microscopy.

    PubMed

    Ventosa, Edgar; Madej, Edyta; Zampardi, Giorgia; Mei, Bastian; Weide, Philipp; Antoni, Hendrik; La Mantia, Fabio; Muhler, Martin; Schuhmann, Wolfgang

    2017-01-25

    The high (de)lithiation potential of TiO2 (ca. 1.7 V vs Li/Li(+) in 1 M Li(+)) decreases the voltage and, thus, the energy density of a corresponding Li-ion battery. On the other hand, it offers several advantages such as the (de)lithiation potential far from lithium deposition or absence of a solid electrolyte interphase (SEI). The latter is currently under controversial debate as several studies reported the presence of a SEI when operating TiO2 electrodes at potentials above 1.0 V vs Li/Li(+). We investigate the formation of a SEI at anatase TiO2 electrodes by means of X-ray photoemission spectroscopy (XPS) and scanning electrochemical microscopy (SECM). The investigations were performed in different potential ranges, namely, during storage (without external polarization), between 3.0-2.0 V and 3.0-1.0 V vs Li/Li(+), respectively. No SEI is formed when a completely dried and residues-free TiO2 electrode is cycled between 3.0 and 2.0 V vs Li/Li(+). A SEI is detected by XPS in the case of samples stored for 6 weeks or cycled between 3.0 and 1.0 V vs Li/Li(+). With use of SECM, it is verified that this SEI does not possess the electrically insulating character as expected for a "classic" SEI. Therefore, we propose the term apparent SEI for TiO2 electrodes to differentiate it from the protecting and effective SEI formed at graphite electrodes.

  6. High-Fidelity e-Learning: SEI’s Virtual Training Environment (VTE)

    DTIC Science & Technology

    2009-01-01

    the rights of the trademark holder. Internal use. PeTillission to reproduce this document and to prepare derivative works from this document for... internal use is granted, provided the copyTight and "No Wammty" statements are included with all reproductions and derivative works. External use. This...18 19 21 21 22 22 23 25 25 i I CMU/SEI-TR-2009-005 Appendix A Appendix B Bibliography Defense Information Systems Agency (DISA) Case Study U. S

  7. Electronic structure and defect properties of Tl6SeI4: Density functional calculations

    NASA Astrophysics Data System (ADS)

    Biswas, Koushik; Du, Mao-Hua; Singh, David J.

    2012-10-01

    We report density functional calculations of electronic structure, phase diagram, and dielectric, optical, and defect properties of Tl6SeI4. We discuss how electronic structure and defect properties affect resistivity and carrier mobility-lifetime (μτ) products in Tl6SeI4. We find large Born effective charges due to covalency involving Tl-6p states. High Born charges generally enhance the static dielectric constant. This provides a mechanism for effective screening of charged defects and impurities. We find that high resistivity can be obtained under near-stoichiometric growth conditions via Fermi level pinning near the middle of the band gap by shallow donors and acceptors, as opposed to deep traps that can give high resistivity, but at the expense of short carrier drift lengths. Defect calculations also reveal the presence of deep native donors that may cause electron trapping. The experimentally observed good μτ products may be explained by a combination of small effective masses and effective screening of charged defects. High resistivity and good μτ products make Tl6SeI4 a promising room-temperature radiation detector material. We also show the calculated defect diffusion barriers, which affect defect migration under external bias in a detector.

  8. SeisCode: A seismological software repository for discovery and collaboration

    NASA Astrophysics Data System (ADS)

    Trabant, C.; Reyes, C. G.; Clark, A.; Karstens, R.

    2012-12-01

    SeisCode is a community repository for software used in seismological and related fields. The repository is intended to increase discoverability of such software and to provide a long-term home for software projects. Other places exist where seismological software may be found, but none meet the requirements necessary for an always current, easy to search, well documented, and citable resource for projects. Organizations such as IRIS, ORFEUS, and the USGS have websites with lists of available or contributed seismological software. Since the authors themselves do often not maintain these lists, the documentation often consists of a sentence or paragraph, and the available software may be outdated. Repositories such as GoogleCode and SourceForge, which are directly maintained by the authors, provide version control and issue tracking but do not provide a unified way of locating geophysical software scattered in and among countless unrelated projects. Additionally, projects are hosted at language-specific sites such as Mathworks and PyPI, in FTP directories, and in websites strewn across the Web. Search engines are only partially effective discovery tools, as the desired software is often hidden deep within the results. SeisCode provides software authors a place to present their software, codes, scripts, tutorials, and examples to the seismological community. Authors can choose their own level of involvement. At one end of the spectrum, the author might simply create a web page that points to an existing site. At the other extreme, an author may choose to leverage the many tools provided by SeisCode, such as a source code management tool with integrated issue tracking, forums, news feeds, downloads, wikis, and more. For software development projects with multiple authors, SeisCode can also be used as a central site for collaboration. SeisCode provides the community with an easy way to discover software, while providing authors a way to build a community around their

  9. In situ scanning tunneling microscopy studies of the SEI formation on graphite electrodes for Li+-ion batteries

    NASA Astrophysics Data System (ADS)

    Seidl, Lukas; Martens, Slađana; Ma, Jiwei; Stimming, Ulrich; Schneider, Oliver

    2016-07-01

    The SEI-formation on graphitic electrodes operated as an Li+-ion battery anode in a standard 1 M LiPF6 EC/DMC (1 : 1) electrolyte has been studied in situ by EC-STM. Two different modes of in situ study were applied, one, which allowed to follow topographic and crystallographic changes (solvent cointercalation, graphite exfoliation, SEI precipitation on the HOPG basal plane) of the graphite electrode during SEI-formation, and the second, which gave an insight into the SEI precipitation on the HOPG basal plane in real time. From the in situ EC-STM studies, not only conclusions about the SEI-topography could be drawn, but also about the formation mechanism and the chemical composition, which strongly depend on the electrode potential. It was shown that above 1.0 V vs. Li/Li+ the SEI-formation is still reversible, since the molecular structure of the solvent molecules remains intact during an initial reduction step. During further reduction, the molecular structures of the solvents are destructed, which causes the irreversible charge loss. The STM studies were completed by electrochemical methods, like cyclic voltammetry, the potentiostatic intermittent titration technique and charge/discharge tests of MCMB electrodes.

  10. An application of queuing theory to SIS and SEIS epidemic models.

    PubMed

    Hernandez-Suarez, Carlos M; Castillo-Chavez, Carlos; Lopez, Osval Montesinos; Hernandez-Cuevas, Karla

    2010-10-01

    In this work we consider every individual of a population to be a server whose state can be either busy (infected) or idle (susceptible). This server approach allows to consider a general distribution for the duration of the infectious state, instead of being restricted to exponential distributions. In order to achieve this we first derive new approximations to quasistationary distribution (QSD) of SIS (Susceptible- Infected- Susceptible) and SEIS (Susceptible- Latent- Infected- Susceptible) stochastic epidemic models. We give an expression that relates the basic reproductive number, R0 and the server utilization,p.

  11. A Bibliography of Externally Published Works by the SEI Engineering Techniques Program

    DTIC Science & Technology

    1992-08-01

    disciplines. Supporting material can be found in many standard engineering texts. [Feiler88] Feller, RH.; Smeaton , R. "Managing Development of Very Large...17,20,21,22, 23, 24, 25 F r Smeaton , R. 16Feiler, P.H. 4, 12, 14, 16, 17 Smith, D. 7 G Spector, A. 8 Garlan, D. 17 Stevens, S.M. 7, 11, 25,26 Stewart...RESPONSIBLE INDIVIDUAL 22b. TELEPHONE NUMBER (Include Area Code) 22e. OFFICE SYMBOL John S. Herman, Capt, USAF (412) 268-7631 ESC/AVS (SEI) DD FORM

  12. Experimental porcine model of complex fistula-in-ano

    PubMed Central

    A Ba-Bai-Ke-Re, Ma-Mu-Ti-Jiang; Chen, Hui; Liu, Xue; Wang, Yun-Hai

    2017-01-01

    AIM To establish and evaluate an experimental porcine model of fistula-in-ano. METHODS Twelve healthy pigs were randomly divided into two groups. Under general anesthesia, the experimental group underwent rubber band ligation surgery, and the control group underwent an artificial damage technique. Clinical magnetic resonance imaging (MRI) and histopathological evaluation were performed on the 38th d and 48th d after surgery in both groups, respectively. RESULTS There were no significant differences between the experimental group and the control group in general characteristics such as body weight, gender, and the number of fistula (P > 0.05). In the experimental group, 15 fistulas were confirmed clinically, 13 complex fistulas were confirmed by MRI, and 11 complex fistulas were confirmed by histopathology. The success rate in the porcine complex fistula model establishment was 83.33%. Among the 18 fistulas in the control group, 5 fistulas were confirmed clinically, 4 complex fistulas were confirmed by MRI, and 3 fistulas were confirmed by histopathology. The success rate in the porcine fistula model establishment was 27.78%. Thus, the success rate of the rubber band ligation group was significantly higher than the control group (P < 0.05). CONCLUSION Rubber band ligation is a stable and reliable method to establish complex fistula-in-ano models. Large animal models of complex anal fistulas can be used for the diagnosis and treatment of anal fistulas. PMID:28348488

  13. The SEIS Experiment for the InSight mission: status and performance expectations

    NASA Astrophysics Data System (ADS)

    Mimoun, David; Lognonne, Philippe; Banerdt, W. Bruce; Laudet, Philippe; De Raucourt, Sébastien; IJpelaan, Frans; Kerjean, Laurent; Perez, Rene; Pont, Gabriel; Sylvestre-Baron, Annick; verdier, Nicolas; Denise, Robert; Feldman, Jason; Hurst, Ken; Klein, Kerry; Giardini, Domenico; Zweifel, Peter; Pike, W. Tom; Calcutt, Simon; Bramanti, Christina

    2015-04-01

    The Insight NASA Discovery mission, led by the Jet Propulsion Laboratory, will deploy in September 2016 a very broadband seismometer on the Mars surface, SEIS (Seismic Experiment for Interior Structure). It is a hybrid 3-axes instrument, which encloses 3 very broadband oblique sensors and 3 short period sensors. The sensor assembly and its wind and thermal shield will by deployed on the Mars surface from the Phoenix-like spacecraft by a robotic arm (IDS). The acquisition system will be hosted in the spacecraft warm electronics box, and connected to the deployed sensor assembly by a tether. The SEIS experiment is provided by CNES, the French Space Agency that makes the coordination of a wide consortium including IPGP of Paris (SEIS PI Institution), Imperial College of London, Oxford University, MPS of Göttingen, ETH of Zürich, ISAE from Toulouse and the Jet Propulsion Laboratory of Pasadena. In addition to the seismometer, the Insight payload will also include a suite of instruments complementary to the seismometer, such as a precision temperature sensor, a micro-barometer, a magnetometer and a wind sensor, making it the first geophysical multi-parameter station on another planet. A heat flow sensor and geodetic measurements will provide additional science measurements, in order to constrain the internal structure of Mars. Several challenges have been overcome to design and realize the planetary seismometer, which will exhibit a noise of about 10-9 m/s2/sqrt(Hz) in its seismic bandwidth bandwidth (0.01-1 Hz) for the very broadband component. These challenges include a very efficient insulation from the external temperature variations, and a finely crafted mechanical design to keep the extreme sensitivity of the seismometer, while allowing enough robustness for the harsh mechanical environment encountered during the launch and landing sequences. Also, specific attention has been paid to understanding the various environment contributions to the noise figure. A

  14. Ano-Genital Warts and HIV Status– A Clinical Study

    PubMed Central

    Sharma, Shimpa; Gulbake, Arvind

    2017-01-01

    Introduction Ano-Genital Warts (AGW) like other Sexually Transmitted Diseases (STD) is associated with Human Immunodeficiency Virus (HIV) infection. This study of AGW was done in HIV positive and HIV negative patients. Aim To study the risk factors and clinical presentations of ano-genital warts in HIV positive and negative patients. Materials and Methods A comparative, cross-sectional, descriptive study of 25 HIV positive and 25 HIV negative (n=50) AGW patients between 15-60 years of both sex was conducted in Dr. D. Y. Patil Hospital and Research Centre from July 2014 to July 2016. Results Significant association of HIV positivity (p<0.05) was observed between age group of 15-30 years and HIV negative status (p<0.05) in age group of 31-45 years. HIV positive status significantly higher in patients with self-admitted multiple sexual partners (p<0.01), homosexuality (p<0.05) and presentation with anal warts (p<0.01). HIV negative status correlated significantly with single sexual partner admission (p<0.01) and hetero-sexuality (p<0.05). Gender did not show significant association with number of sexual partners or HIV positivity. Extra-genital or only genital warts had no association with HIV status. Co-STDs though more in number in ser-positive group, did not show any significant association with HIV positivity (p>0.05). No patient presented with changes of malignancy. Four were adolescents below 19 years. Two patients had atypical presentations of giant condylomata i.e., Buschke-Lowenstein Tumour (BLT). Conclusion HIV positivity was significantly associated with the risk factors of age below 30 years, homo sexuality and multiple sexual partners. Anal warts were significantly common in HIV positive patients. Four adolescents with AGW underline the need for high risk behaviour counselling. No patient had malignant ano-genital warts. Follow up of these patients with Human Papilloma Virus (HPV) sub-typing is necessary. PMID:28274028

  15. Interim Columbia and Snake rivers flow improvement measures for salmon: Final Supplemental Environmental Impact Statement (SEIS)

    SciTech Connect

    Not Available

    1993-03-01

    Public comments are sought on this final SEIS, which supplements the 1992 Columbia River Salmon Flow Measures Options Analysis (OA)/Environmental Impact Statement (EIS). The Corps of Engineers, in cooperation with the Bonneville Power Administration and the Bureau of Reclamation proposes five alternatives to improve flows of water in the lower Columbia-Snake rivers in 1993 and future years to assist the migration of juvenile and adult anadromous fish past eight hydropower dams. These are: (1) Without Project (no action) Alternative, (2) the 1992 Operation, (3) the 1992 Operation with Libby/Hungry Horse Sensitivity, (4) a Modified 1992 Operation with Improvements to Salmon Flows from Dworshak, and (5) a Modified 1992 Operation with Upper Snake Sensitivity. Alternative 4, Modified 1992 Operations, has been identified as the preferred alternative.

  16. NSPWG-recommended safety requirements and guidelines for SEI nuclear propulsion

    NASA Technical Reports Server (NTRS)

    Marshall, Albert C.; Sawyer, J. C., Jr.; Bari, Robert A.; Brown, Neil W.; Cullingford, Hatice S.; Hardy, Alva C.; Lee, James H.; Mcculloch, William H.; Niederauer, George F.; Remp, Kerry

    1992-01-01

    An interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top-level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of safety functional requirements. In addition, the NSPWG reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. Safety requirements were developed for reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, and safeguards. Guidelines were recommended for risk/reliability, operational safety, flight trajectory and mission abort, space debris and meteoroids, and ground test safety. In this paper the specific requirements and guidelines will be discussed.

  17. NSPWG-recommended safety requirements and guidelines for SEI nuclear propulsion

    NASA Astrophysics Data System (ADS)

    Marshall, Albert C.; Sawyer, J. C., Jr.; Bari, Robert A.; Brown, Neil W.; Cullingford, Hatice S.; Hardy, Alva C.; Lee, James H.; McCulloch, William H.; Niederauer, George F.; Remp, Kerry

    1992-07-01

    An interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top-level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of safety functional requirements. In addition, the NSPWG reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. Safety requirements were developed for reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, and safeguards. Guidelines were recommended for risk/reliability, operational safety, flight trajectory and mission abort, space debris and meteoroids, and ground test safety. In this paper the specific requirements and guidelines will be discussed.

  18. Electronic states and spectroscopic parameters of selenium monoiodide, SeI: A theoretical contribution

    NASA Astrophysics Data System (ADS)

    Belinassi, Antonio Ricardo; Alves, Tiago Vinicius; Ornellas, Fernando R.

    2017-03-01

    A new species, selenium monoiodide (SeI), was investigated for the first time at a high level of theoretical approach, SA-CASSCF/MRCI. The overall picture of all doublet and quartet (Λ + S) states correlating with the three lowest dissociation channels and the associated Ω states provide reliable results to help understand the lack of experimental data on its transitions and to plan the investigation and determination of spectroscopic parameters. Transition probabilities were computed for the transitions X2 - X1, A1 - X1, A2 - X1, and A2 - X2, originated from the spin-forbidden 1 4Σ- - X 2Π system, and the corresponding radiative lifetimes evaluated.

  19. NSPWG-recommended safety requirements and guidelines for SEI nuclear propulsion

    SciTech Connect

    Marshall, A.C.; Lee, J.H.; McCulloch, W.H.; Sawyer, J.C. Jr.; Bari, R.A.; Brown, N.W.; Cullingford, H.S.; Hardy, A.C.; Niederauer, G.F.; Remp, K.; Rice, J.W.; Sholtis, J.A.

    1992-09-01

    An Interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top- level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of Safety Functional Requirements. In addition the NSPWG reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. Safety requirements were developed for reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, and safeguards. Guidelines were recommended for risk/reliability, operational safety, flight trajectory and mission abort, space debris and meteoroids, and ground test safety. In this paper the specific requirements and guidelines will be discussed.

  20. NSPWG-recommended safety requirements and guidelines for SEI nuclear propulsion

    SciTech Connect

    Marshall, A.C.; Lee, J.H.; McCulloch, W.H. ); Sawyer, J.C. Jr. ); Bari, R.A. ); Brown, N.W. ); Cullingford, H.S.; Hardy, A.C. (National Aeronautics and Space Administ

    1992-01-01

    An Interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top- level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of Safety Functional Requirements. In addition the NSPWG reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. Safety requirements were developed for reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, and safeguards. Guidelines were recommended for risk/reliability, operational safety, flight trajectory and mission abort, space debris and meteoroids, and ground test safety. In this paper the specific requirements and guidelines will be discussed.

  1. Assessment of the state of the art in life support environmental control for SEI

    NASA Technical Reports Server (NTRS)

    Simonds, Charles H.; Noyes, Gary P.

    1992-01-01

    This paper defines the types of technology that would be used in a lunar base for environmental control and life support system and how it might relate to in situ materials utilization (ISMU) for the Space Exploration Initiative (SEI). There are three types of interaction between ISMU and the Environmental Control and Life Support System (ECLSS): (1) ISMU can reduce cost of water, oxygen, and possibly diluent gasses provided to ECLSS--a corollary to this fact is that the availability of indigenous resources can dramatically alter life support technology trade studies; (2) ISMU can use ECLSS waste systems as a source of reductant carbon and hydrogen; and (3) ECLSS and ISMU, as two chemical processing technologies used in spacecraft, can share technology, thereby increasing the impact of technology investments in either area.

  2. Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells

    PubMed Central

    Park, Jinhong; Jeon, Dong-kyu; Jo, Sungwoo; Lee, Ho K.

    2017-01-01

    Anoctamin 1 (ANO1), a calcium-activated chloride channel, is highly amplified in prostate cancer, the most common form of cancer and leading causes of cancer death in men, and downregulation of ANO1 expression or its functional activity is known to inhibit cell proliferation, migration and invasion in prostate cancer cells. Here, we performed a cell-based screening for the identification of ANO1 inhibitors as potential anticancer therapeutic agents for prostate cancer. Screening of ~300 selected bioactive natural products revealed that luteolin is a novel potent inhibitor of ANO1. Electrophysiological studies indicated that luteolin potently inhibited ANO1 chloride channel activity in a dose-dependent manner with an IC50 value of 9.8 μM and luteolin did not alter intracellular calcium signaling in PC-3 prostate cancer cells. Luteolin inhibited cell proliferation and migration of PC-3 cells expressing high levels of ANO1 more potently than that of ANO1-deficient PC-3 cells. Notably, luteolin not only inhibited ANO1 channel activity, but also strongly decreased protein expression levels of ANO1. Our results suggest that downregulation of ANO1 by luteolin is a potential mechanism for the anticancer effect of luteolin. PMID:28362855

  3. Adenocarcinoma in an ano-vaginal fistula in Crohn's disease

    PubMed Central

    Alfa-Wali, Maryam; Atinga, Angela; Mohsen, Yasser; Anthony, Andrew; Myers, Alistair

    2013-01-01

    INTRODUCTION Fistulas are a relatively common occurrence in Crohn's disease (CD), and often present early in the disease process. Additionally, patients suffering from either CD or ulcerative colitis are shown to have an increased risk of colorectal malignancies compared with the general population. PRESENTATION OF CASE We present a case of adenocarcinoma in an ano-vaginal fistula in a patient with longstanding CD. DISCUSSION Various pathogenic mechanisms for the development of carcinoma in fistulas have been suggested, but there is no consensus and indeed this risk may be cumulative. In this case report, we also discuss the pathogenesis of mucinous adenocarcinoma in fistulas secondary to CD. CONCLUSION Better detection of adenocarcinoma in patients presenting with persistent non-resolving fistulas in the presence of CD should be undertaken with regular biopsies following examinations under anaesthetic of the anorectum. PMID:23702362

  4. An Allegory of Addiction Recovery: Exploring the Performance of "Eumenides" by Aeschylus, as Adapted by 18 ANO Theatre Group

    ERIC Educational Resources Information Center

    Zontou, Zoe

    2013-01-01

    This paper examines the performance of the "Eumenides," as adapted and performed by 18 ANO theatre group. 18 ANO is the theatre group of the Drug dependence treatment unit 18 ANO of Attica's Psychiatric Hospital, which is based in Athens, Greece. Each year 18 ANO organises performances in the wider community with the aim of promoting…

  5. Identification of a lipid scrambling domain in ANO6/TMEM16F

    PubMed Central

    Yu, Kuai; Whitlock, Jarred M; Lee, Kyleen; Ortlund, Eric A; Yuan Cui, Yuan; Hartzell, H Criss

    2015-01-01

    Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated bidirectional transport of phospholipids down their concentration gradient between membrane leaflets. ANO6/TMEM16F has been shown to be essential for Ca2+-dependent PLS, but controversy surrounds whether ANO6 is a phospholipid scramblase or an ion channel like other ANO/TMEM16 family members. Combining patch clamp recording with measurement of PLS, we show that ANO6 elicits robust Ca2+-dependent PLS coinciding with ionic currents that are explained by ionic leak during phospholipid translocation. By analyzing ANO1-ANO6 chimeric proteins, we identify a domain in ANO6 necessary for PLS and sufficient to confer this function on ANO1, which normally does not scramble. Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets. These findings provide a mechanistic framework for understanding PLS and how ANO6 functions in this process. DOI: http://dx.doi.org/10.7554/eLife.06901.001 PMID:26057829

  6. Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts

    PubMed Central

    You, Jia; Wu, Di; Yu, Yang; Liu, Chang; Wang, Lei; Wang, Fei; Xu, Lu; Wang, Liqun; Wang, Nan; Tian, Xing; Wang, Falin; Liang, Hongbin; Gao, Yating; Cui, Xiaobo; Ji, Guohua; Bai, Jing; Yu, Jingcui; Meng, Xiangning; Jin, Yan; Sun, Wenjing; Guan, Xin-yuan; Zhang, Chunyu; Fu, Songbin

    2016-01-01

    Background Sei-1 is an oncogene capable of inducing double minute chromosomes (DMs) formation. DMs are hallmarks of amplification and contribute to oncogenesis. However, the mechanism of Sei-1 inducing DMs formation remains unelucidated. Results DMs formation significantly increased during serial passage in vivo and gradually decreased following culture in vitro. micro nuclei (MN) was found to be responsible for the reduction. Of the DMs-carrying genes, Met was found to be markedly amplified, overexpressed and highly correlated with DMs formation. Inhibition of Met signaling decreased the number of DMs and reduced the amplification of the DMs-carrying genes. We identified a 3.57Mb DMs representing the majority population, which consists of the 1.21 Mb AMP1 from locus 6qA2 and the 2.36 Mb AMP2 from locus 6qA2-3. Materials and Methods We employed NIH-3T3 cell line with Sei-1 overexpression to monitor and characterize DMs in vivo and in vitro. Array comparative genome hybridization (aCGH) and fluorescence in situ hybridization (FISH) were performed to reveal amplification regions and DMs-carrying genes. Metaphase spread was prepared to count the DMs. Western blot and Met inhibition rescue experiments were performed to examine for involvement of altered Met signaling in Sei-1 induced DMs. Genomic walking and PCR were adopted to reveal DMs structure. Conclusions Met is an important promotor of DMs formation. PMID:27494853

  7. 77 FR 36032 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement (SEIS) and To Conduct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... TransCanada Keystone XL Pipeline Proposed To Extend From Phillips, MT (the Border Crossing) to Steele... TransCanada's proposed international pipeline project (the revised Keystone XL Project), which is... a Presidential permit for the revised Keystone XL Pipeline Project. The SEIS will supplement...

  8. 75 FR 52589 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement (SEIS) for the Cal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... (SEIS) for the Cal Black Memorial Airport at Halls Crossing, UT AGENCY: Federal Aviation Administration... Decision concerning the development of Cal Black Memorial Airport. This supplemental EIS does not involve any new development or project at the airport. The Cal Black Memorial Airport opened in April 1992....

  9. SeisCube Instrument and Environment Considerations for the Didymos System Geophysical Exploration

    NASA Astrophysics Data System (ADS)

    Cadu, Alexandre; Murdoch, Naomi; Mimoun, David; Karatekin, Ozgur; Garica, Raphaël F.; Carrasco, Jose A.; De Quiros, Francisco G.; Vasseur, Hugues; Eubanks, Marshall; Radley, Charles; Ritter, Birgit; Dehant, Veronique

    2016-04-01

    In the context of the Asteroid Impact & Deviation Assessment (AIDA) mission proposed by ESA and NASA, the Asteroid Geophysical Explorer (AGEX) mission concept has been selected for a preliminary study phase. Two 3-Unit CubeSats are embedded into the AIM probe and released into the asteroid binary system [1]. SeisCube will be deployed close to the secondary to reach its surface at a low relative velocity in order to stay on the ground after several rebounds, in a similar way that is foreseen for Mascot-2. The purpose of SeisCube is to provide information about the surface, the sub-surface and the internal structure of the asteroid, by analyzing rebound acceleration profile and seismic activity [2]. We describe the considered instrumentation necessary to fulfill the science objectives (gravimeters, accelerometers, geophones, etc.) in terms of measurement dynamics, frequency ranges, acquisition methods and other common budgets for space equipment. We also present the environment considerations which have to be taken into account for the platform and payload designs. The thermal aspect will be particularly discussed since it is a major issue in the airless body exploration [3] [4]. It implies some modifications in the CubeSat structure, integration and thermal regulation to ensure survival and operations under extreme conditions at the asteroid surface. We then describe the platform subsystems needed to ensure the operations after the deployment and the associated budgets and accommodation. As a direct consequence of the previous topics, we will finally discuss the possible trades-off to satisfy the main science requirements and the associated concept of operations. [1] O. Karatekin, D. Mimoun, J. A. Carrasco, N. Murdoch, A. Cadu, R. F. Garcia, F. G. De Quiros, H. Vasseur, B. Ritter, M. Eubanks, C. Radley and V. Dehant, "The Asteroid Geophysical Explorer (AGEX): Proposal to explore Didymos system using Cubsats," in European Geophysical Union, 2016. [2] N. Murdoch, A

  10. Update on the Next Generation Earthquake Early Warning in SeisComP3

    NASA Astrophysics Data System (ADS)

    Behr, Yannik; Boese, Maren; Smith, Deborah; Clinton, John; Meier, Men-Andrin

    2016-04-01

    An effective Earthquake Early Warning (EEW) system has to be evolutionary, updating its alerts as new data becomes available progressively in real-time. Typically, this involves combining different algorithms tailored towards providing alerts for either moderate or large sized earthquakes using either seismic or geodetic data, or a combination of both. A common approach in most algorithms is to rapidly estimate rupture parameters and then use ground motion prediction equations to compute the expected peak ground motion at a target site. For moderate size earthquakes (SeisComP3, combining point-source algorithms (Gutenberg algorithm: Meier et al. [2015]; Virtual Seismologist: Cua and Heaton [2007]) with a finite rupture algorithm (FinDer: Böse et al., [2012]). Relying on a widely used real-time monitoring platform, such as SeisComP3, facilitates testing and operating new algorithms in real-time in different seismic networks and thus different tectonic regimes. Special focus has also been given to modularity and

  11. RapidSeis: Enabling User-Defined Seismological Waveform Data Processing over the Grid

    NASA Astrophysics Data System (ADS)

    Spinuso, Alessandro; Heath, Andy; Koestjer, Jos; Trani, Luca

    2010-05-01

    The objective of this JISC-funded pilot project was to remove perceived barriers to uptake of an application that performs analysis of seismic waveform data. The aim was to provide the seismological community with a simplified system that overcame important barriers such as installation and understanding of the analysis package, location and transfer of large amounts of input data and visualisation of results. The project combined the expertise of three distinct teams. The Orfeus Data Centre provided discovery services and access management to distributed earthquake waveform data and metadata, supported by technologies such as webservices, SPARQL/RDF and a JSR-168 portal framework based on the WSRP portlet architecture. Analysis and visualisation of the waveform data were performed by SDX (Seismic Data eXplorer) developed at the University of Liverpool. SDX formed the core processing engine - this application's functionality can be extended via user-defined algorithms coded as plugins. The processing engine was supported by several webservice-enabled modules used for data and plugin exchange. The user, data and processing infrastructure were connected using the Rapid framework created by the UK National e-Science Centre. Rapid generates intuitive interfaces to the processing core in the form of two self-contained JSR-168 remote portlets. One portlet facilitated plugin creation, whilst the other allowed execution of plugin code within the processing core running on a campus or national Grid infrastructure. The RapidSeis system was deployed within a community gateway: the NERIES web portal. Although RapidSeis originated within the seismological community we suggest it forms a framework which could be exploited in different domains or scientific gateways where users can discover data, store data within a cart and wish to apply specialised processing algorithms remotely through a web browser. Processing performed on Grid infrastructure is completely transparent: the

  12. Ionic Liquid-Enhanced Solid State Electrolyte Interface (SEI) for Lithium Sulfur Batteries

    SciTech Connect

    Zheng, Jianming; Gu, Meng; Chen, Honghao; Meduri, Praveen; Engelhard, Mark H.; Zhang, Jiguang; Liu, Jun; Xiao, Jie

    2013-05-16

    Li-S battery is a complicated system with many challenges existing before its final market penetration. While most of the reported work for Li-S batteries is focused on the cathode design, we demonstrate in this work that the anode consumption accelerated by corrosive polysulfide solution also critically determines the Li-S cell performance. To validate this hypothesis, ionic liquid (IL) N-methyl-N-butylpyrrolidinium bis(trifluoromethylsulfonyl)imide (Py14TFSI) has been employed to modify the properties of SEI layer formed on Li metal surface in Li-S batteries. It is found that the IL-enhanced passivation film on the lithium anode surface exhibits much different morphology and chemical compositions, effectively protecting lithium metal from continuous attack by soluble polysulfides. Therefore, both cell impedance and the irreversible consumption of polysulfides on lithium metal are reduced. As a result, the Coulombic efficiency and the cycling stability of Li-S batteries have been greatly improved. After 120 cycles, Li-S battery cycled in the electrolyte containing IL demonstrates a high capacity retention of 94.3% at 0.1 C rate. These results unveil another important failure mechanism for Li-S batteries and shin the light on the new approaches to improve Li-S battery performances.

  13. ANO1 as a marker of oral squamous cell carcinoma and silencing ANO1 suppresses migration of human scc-25 cells

    PubMed Central

    Li, Yadong; Zhang, Jinsong

    2014-01-01

    Objectives: The purpose of this study is to confirm that ANO1 correlates with occurrence and metastasis of OSCC. Study Design: Immunohistochemistry was used to detect the expression of ANO1 in 160 specimens of OSCC and normal tissues. Lentiviral silencing ANO1 was used in scc-25 cell line to study the cell migration and cell detachment. Results: Immunohistochemical staining revealed that ANO1 was expressed in a large majority (132 out of 160, 82.5%) of OSCC specimens and that the rate of ANO1 expression in OSCC was significantly higher than that of normal tissue (P<0.05); The rate of ANO1 expression was higher in metastatic tumors than in non-metastatic tumors, and the difference was significant (P<0.05). The results of cell migration assay showed that the percentage of cells through the membrane was 26.61 ±0.81 in assay group, and 54.26 ±3.74 in control group, respectively (t=-16.22,P<0.0001). The results of cell detachment assay showed that the percentage of cells detachment was 37.42 ±0.90 in assay group, and 87.38 ±1.59 in control group, respectively (t=-62.34, P<0.0001). The results of wound healing assay showed the assay group had a reduced migration rate compared with the control group in 32 h (F=1038.78, P<0.0001). Wound closure was no significantly different between the assay and control cells when DIDS was used in wound healing assay (F=4.61,P>0.05). Conclusions: Our study shows that abnormal expression of ANO1 correlated with the occurrence and metastasis of OSCC in clinical specimens and that silencing ANO1 greatly reduced migration ability of scc-25 cells. Calcium activated chloride channel activity of ANO1 promoted the cell migration. Thus, ANO1 could represent a new diagnostic biomarker and a potentially important therapeutic target of OSCC. Key words:Oral squamous cell carcinoma, chloride channel, metastasis. PMID:24316695

  14. ANOs 3–7 in the anoctamin/Tmem16 Cl− channel family are intracellular proteins

    PubMed Central

    Duran, Charity; Qu, Zhiqiang; Osunkoya, Adeboye O.; Cui, Yuanyuan

    2012-01-01

    Ca2+-activated Cl− channels (CaCCs) participate in numerous physiological functions such as neuronal excitability, sensory transduction, and transepithelial fluid transport. Recently, it was shown that heterologously expressed anoctamins ANO1 and ANO2 generate currents that resemble native CaCCs. The anoctamin family (also called Tmem16) consists of 10 members, but it is not known whether all members of the family are CaCCs. Expression of ANOs 3–7 in HEK293 cells did not generate Cl− currents activated by intracellular Ca2+, as determined by whole cell patch clamp electrophysiology. With the use of confocal imaging, only ANO1 and ANO2 traffic to the plasma membrane when expressed heterologously. Furthermore, endogenously expressed ANO7 in the human prostate is predominantly intracellular. We took a chimeric approach to identify regions critical for channel trafficking and function. However, none of the chimeras of ANO1 and ANO5/7 that we made trafficked to the plasma membrane. Our results suggest that intracellular anoctamins may be endoplasmic reticulum proteins, although it remains unknown whether these family members are CaCCs. Determining the role of anoctamin family members in ion transport will be critical to understanding their functions in physiology and disease. PMID:22075693

  15. A causa das estações do ano: modelos mentais

    NASA Astrophysics Data System (ADS)

    de Campos, J. A. S.; de Araujo, J. F. S.

    2003-08-01

    A década de 70 do século passado foi marcada pelo estudo das concepções alternativas que os alunos trazem para a sala de aula. A identificação destas concepções foi o ponto de partida para promover a mudança conceitual, onde as pré-concepções seriam trocadas pelas concepções científicas. Na década seguinte, surgiram muitas propostas de estratégias educacionais para facilitar esta troca, na sua maioria baseadas na idéia do conflito cognitivo, proposta por Piaget. Entretanto, os resultados pouco animadores conduziram à percepção de que a mudança conceitual é um processo mais complexo. Pelas idéias da Ciência Cognitiva, a mudança conceitual é uma mudança progressiva dos modelos mentais que o aluno tem sobre o mundo físico, através de enriquecimento e revisão. A causa das Estações do Ano é um tópico sobre o qual a maioria dos estudantes apresenta concepções alternativas. Os autores fizeram um levantamento sobre as pré-concepções encontradas em trabalhos sobre o tema (16 referências), procurando encontrar elementos comuns que indicassem a presença de modelos mentais específicos. As pré-concepções encontradas na literatura foram obtidas usando-se diversas metodologias (desde entrevistas clínicas até questionários de múltipla escolha) e envolvendo alunos e professores de diferentes regiões geográficas. A partir de uma análise aprofundada de cada trabalho, e utilizando-se a técnica das Redes Sistêmicas, chegou-se a conclusão que as diversas pré-concepções identificadas (em torno de 50), poderiam ser representadas por 6 modelos mentais, onde a explicação da causa das estações do ano tem um mecanismo causal responsável. Os mecanismos causais identificados foram: a dependência da distância, a dependência da orientação, a dependência conjunta da distância e orientação, a dependência da obstrução, a dependência da velocidade e a dependência da inclinação dos raios solares. Foram ainda identificadas

  16. Identification of Li-Ion Battery SEI Compounds through (7)Li and (13)C Solid-State MAS NMR Spectroscopy and MALDI-TOF Mass Spectrometry.

    PubMed

    Huff, Laura A; Tavassol, Hadi; Esbenshade, Jennifer L; Xing, Wenting; Chiang, Yet-Ming; Gewirth, Andrew A

    2016-01-13

    Solid-state (7)Li and (13)C MAS NMR spectra of cycled graphitic Li-ion anodes demonstrate SEI compound formation upon lithiation that is followed by changes in the SEI upon delithiation. Solid-state (13)C DPMAS NMR shows changes in peaks associated with organic solvent compounds (ethylene carbonate and dimethyl carbonate, EC/DMC) upon electrochemical cycling due to the formation of and subsequent changes in the SEI compounds. Solid-state (13)C NMR spin-lattice (T1) relaxation time measurements of lithiated Li-ion anodes and reference poly(ethylene oxide) (PEO) powders, along with MALDI-TOF mass spectrometry results, indicate that large-molecular-weight polymers are formed in the SEI layers of the discharged anodes. MALDI-TOF MS and NMR spectroscopy results additionally indicate that delithiated anodes exhibit a larger number of SEI products than is found in lithiated anodes.

  17. A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.

    PubMed

    Strege, Peter R; Bernard, Cheryl E; Mazzone, Amelia; Linden, David R; Beyder, Arthur; Gibbons, Simon J; Farrugia, Gianrico

    2015-11-01

    Anoctamin 1 (Ano1; TMEM16A) is a Ca(2+)-activated Cl(-) channel (CACC) expressed in interstitial cells of Cajal. The mechanisms by which Ca(2+) regulates Ano1 are incompletely understood. In the gastrointestinal tract, Ano1 is required for normal slow wave activity and is involved in regulating cell proliferation. Splice variants of Ano1 have varying electrophysiological properties and altered expression in disease states. Recently, we identified a transcript for human Ano1 containing a novel exon-"exon 0" upstream of and in frame with exon 1. The electrophysiological properties of this longer Ano1 isoform are unknown. Our aim was to determine the functional contribution of the newly identified exon to the Ca(2+) sensitivity and electrophysiological properties of Ano1. Constructs with [Ano1(+0)] or without [Ano1(-0)] the newly identified exon were transfected into human embryonic kidney-293 cells. Voltage-clamp electrophysiology was used to determine voltage- and time-dependent parameters of whole cell Cl(-) currents between isoforms with varying concentrations of intracellular Ca(2+), extracellular anions, or Cl(-) channel inhibitors. We found that exon 0 did not change voltage sensitivity and had no impact on the relative permeability of Ano1 to most anions. Ano1(+0) exhibited greater changes in current density but lesser changes in kinetics than Ano1(-0) in response to varying intracellular Ca(2+). The CACC inhibitor niflumic acid inhibited current with greater efficacy and higher potency against Ano1(+0) compared with Ano1(-0). Likewise, the Ano1 inhibitor T16Ainh-A01 reduced Ano1(+0) more than Ano1(-0). In conclusion, human Ano1 containing exon 0 imparts its Cl(-) current with greater sensitivity to intracellular Ca(2+) and CACC inhibitors.

  18. A novel exon in the human Ca2+-activated Cl− channel Ano1 imparts greater sensitivity to intracellular Ca2+

    PubMed Central

    Strege, Peter R.; Bernard, Cheryl E.; Mazzone, Amelia; Linden, David R.; Beyder, Arthur; Gibbons, Simon J.

    2015-01-01

    Anoctamin 1 (Ano1; TMEM16A) is a Ca2+-activated Cl− channel (CACC) expressed in interstitial cells of Cajal. The mechanisms by which Ca2+ regulates Ano1 are incompletely understood. In the gastrointestinal tract, Ano1 is required for normal slow wave activity and is involved in regulating cell proliferation. Splice variants of Ano1 have varying electrophysiological properties and altered expression in disease states. Recently, we identified a transcript for human Ano1 containing a novel exon-“exon 0” upstream of and in frame with exon 1. The electrophysiological properties of this longer Ano1 isoform are unknown. Our aim was to determine the functional contribution of the newly identified exon to the Ca2+ sensitivity and electrophysiological properties of Ano1. Constructs with [Ano1(+0)] or without [Ano1(−0)] the newly identified exon were transfected into human embryonic kidney-293 cells. Voltage-clamp electrophysiology was used to determine voltage- and time-dependent parameters of whole cell Cl− currents between isoforms with varying concentrations of intracellular Ca2+, extracellular anions, or Cl− channel inhibitors. We found that exon 0 did not change voltage sensitivity and had no impact on the relative permeability of Ano1 to most anions. Ano1(+0) exhibited greater changes in current density but lesser changes in kinetics than Ano1(−0) in response to varying intracellular Ca2+. The CACC inhibitor niflumic acid inhibited current with greater efficacy and higher potency against Ano1(+0) compared with Ano1(−0). Likewise, the Ano1 inhibitor T16Ainh-A01 reduced Ano1(+0) more than Ano1(−0). In conclusion, human Ano1 containing exon 0 imparts its Cl− current with greater sensitivity to intracellular Ca2+ and CACC inhibitors. PMID:26359375

  19. Activation of Ca(2+) -activated Cl(-) channel ANO1 by localized Ca(2+) signals.

    PubMed

    Jin, Xin; Shah, Sihab; Du, Xiaona; Zhang, Hailin; Gamper, Nikita

    2016-01-01

    Ca(2+)-activated chloride channels (CaCCs) regulate numerous physiological processes including epithelial transport, smooth muscle contraction and sensory processing. Anoctamin-1 (ANO1, TMEM16A) is a principal CaCC subunit in many cell types, yet our understanding of the mechanisms of ANO1 activation and regulation are only beginning to emerge. Ca(2+) sensitivity of ANO1 is rather low and at negative membrane potentials the channel requires several micromoles of intracellular Ca(2+) for activation. However, global Ca(2+) levels in cells rarely reach such levels and, therefore, there must be mechanisms that focus intracellular Ca(2+) transients towards the ANO1 channels. Recent findings indeed indicate that ANO1 channels often co-localize with sources of intracellular Ca(2+) signals. Interestingly, it appears that in many cell types ANO1 is particularly tightly coupled to the Ca(2+) release sites of the intracellular Ca(2+) stores. Such preferential coupling may represent a general mechanism of ANO1 activation in native tissues.

  20. DEZ ANOS DE EXPERIÊNCIA DO COMITÊ DE ÉTICA EM PESQUISA DA SECRETARIA DE SAÚDE DO DISTRITO FEDERAL, BRASIL

    PubMed Central

    Novaes, Maria Rita C. G.; Guilhem, Dirce; Lolas, Fernando

    2009-01-01

    O objetivo deste artigo é relatar a experiência do Comitê de Ética em Pesquisa da Secretaria de Estado de Saúde do Distrito Federal (CEP/SES/DF) Brasil, durante o período de 10 anos a partir de sua fundação. Trata-se de uma avaliação descritiva e documental, na modalidade estudo de caso, utilizando-se a totalidade de projetos protocolados no CEP/SES/DF (N° 052/08) nesse período. As pendências mais freqüentes dos projetos foram: termo de consentimento livre e esclarecido (30%), folha de rosto (25%), metodologia (20%), curriculum vitae (12%), planilha de orçamento (9%), outros (4%). O relato das atividades do CEP/SES/DF no período de 10 anos revelou, através de sua produtividade, a legitimidade do processo de análise ética dos protocolos visando à proteção dos participantes da pesquisa. PMID:19888441

  1. Distribution of sei whales (Balaenoptera borealis) in the subarctic-subtropical transition area of the western North Pacific in relation to oceanic fronts

    NASA Astrophysics Data System (ADS)

    Murase, Hiroto; Hakamada, Takashi; Matsuoka, Koji; Nishiwaki, Shigetoshi; Inagake, Denzo; Okazaki, Makoto; Tojo, Naoki; Kitakado, Toshihide

    2014-09-01

    The subarctic-subtropical transition area of the western North Pacific is an important summer feeding grounds of sei whales. The oceanographic structure and circulation of this area are largely determined by strong oceanic fronts and associated geostrophic currents, namely the Polar Front (PF), Subarctic Front (SAF) and Kuroshio Extension Front (KEF). The relationship between the distribution of sei whales and oceanographic fronts was investigated using a generalized additive model (GAM), and the cetacean sighting survey data and oceanographic observations in July from 2000 to 2007 were used in the analysis. The number of individual sei whales was used as the response variable while the distances from the PF, SAF, and KEF to the whales were used as explanatory variables along with the longitude values. Sei whales were concentrated north and south of the SAF and the areas from 250 to 300 km north and from 100 to 200 km south of the SAF were estimated as high-density areas of sei whales. The entire inter-frontal zone between the PF and SAF featured an elevated concentration of sei whales, and the area south of the PF and along the SAF was identified as an important feeding ground of sei whales in July from 2000 to 2007.

  2. VizieR Online Data Catalog: Spectroscopic Indicators in SeisMic Archive (SISMA) (Rainer+, 2016)

    NASA Astrophysics Data System (ADS)

    Rainer, M.; Poretti, E.; Misto, A.; Panzera, M. R.; Molinaro, M.; Cepparo, F.; Roth, M.; Michel, E.; Monteiro, M. J. P. F. G.

    2017-02-01

    We created a large database of physical parameters and variability indicators by fully reducing and analyzing the large number of spectra taken to complement the asteroseismic observations of the COnvection, ROtation and planetary Transits (CoRoT) satellite. CoRoT was launched on 2006 December 27 and it was retired on 2013 June 24. 7103 spectra of 261 stars obtained with the ESO echelle spectrograph High Accuracy Radial velocity Planet Searcher (HARPS) have been stored in the VO-compliant database Spectroscopic Indicators in a SeisMic Archive (SISMA; http://sisma.brera.inaf.it/), along with the CoRoT photometric data of the 72 CoRoT asteroseismic targets. The ground-based activities started with the Large Programme 178.D-0361 using the FEROS spectrograph at the 2.2m telescope of the ESO-La Silla Observatory, and continued with the Large Programmes LP182.D-0356 and LP185.D-0056 using the HARPS instrument at the 3.6m ESO telescope. In the framework of the awarded two HARPS Large Programmes, 15 nights were allocated each semester over nine semesters, from 2008 December to 2013 January, for a total of 135 nights. The HARPS spectrograph covers the spectral range from 3780 to 6910Å, distributed over echelle orders 89-161. We usually used it in the high-efficiency mode EGGS, with resolving power R=80000 to obtain high signal-to-noise ratio (S/N) spectroscopic time series. All of the data (reduced spectra, indicators, and photometric series) are stored as either FITS or PDF files in the SISMA archive and can be accessed at http://sisma.brera.inaf.it/. The data can also be accessed through the Seismic Plus portal (http://voparis-spaceinn.obspm.fr/seismic-plus/), developed in the framework of the SpaceInn project in order to gather and help coordinated access to several different solar and stellar seismic data sources. (1 data file).

  3. Automated infrasound signal detection algorithms implemented in MatSeis - Infra Tool.

    SciTech Connect

    Hart, Darren

    2004-07-01

    MatSeis's infrasound analysis tool, Infra Tool, uses frequency slowness processing to deconstruct the array data into three outputs per processing step: correlation, azimuth and slowness. Until now, an experienced analyst trained to recognize a pattern observed in outputs from signal processing manually accomplished infrasound signal detection. Our goal was to automate the process of infrasound signal detection. The critical aspect of infrasound signal detection is to identify consecutive processing steps where the azimuth is constant (flat) while the time-lag correlation of the windowed waveform is above background value. These two statements describe the arrival of a correlated set of wavefronts at an array. The Hough Transform and Inverse Slope methods are used to determine the representative slope for a specified number of azimuth data points. The representative slope is then used in conjunction with associated correlation value and azimuth data variance to determine if and when an infrasound signal was detected. A format for an infrasound signal detection output file is also proposed. The detection output file will list the processed array element names, followed by detection characteristics for each method. Each detection is supplied with a listing of frequency slowness processing characteristics: human time (YYYY/MM/DD HH:MM:SS.SSS), epochal time, correlation, fstat, azimuth (deg) and trace velocity (km/s). As an example, a ground truth event was processed using the four-element DLIAR infrasound array located in New Mexico. The event is known as the Watusi chemical explosion, which occurred on 2002/09/28 at 21:25:17 with an explosive yield of 38,000 lb TNT equivalent. Knowing the source and array location, the array-to-event distance was computed to be approximately 890 km. This test determined the station-to-event azimuth (281.8 and 282.1 degrees) to within 1.6 and 1.4 degrees for the Inverse Slope and Hough Transform detection algorithms, respectively, and

  4. EAVK "segment c" sequence confers Ca(2+)-dependent changes to the kinetics of full length human Ano1.

    PubMed

    Strege, Peter R; Gibbons, Simon J; Mazzone, Amelia; Bernard, Cheryl E; Beyder, Arthur; Farrugia, Gianrico

    2017-03-23

    Anoctamin1 (Ano1, TMEM16A) is a calcium-activated chloride channel specifically expressed in interstitial cells of Cajal (ICC) of the gastrointestinal (GI) tract muscularis propria. Ano1 is necessary for normal electrical slow waves and ICC proliferation. The full length human Ano1 sequence includes an additional exon, exon "0," at the N-terminus. Ano1 with exon "0" (Ano1(0)) had a lower EC50 for intracellular calcium ([Ca(2+)]i) and faster chloride current (ICl) kinetics. The Ano1 alternative splice variant with segment "c" encoding exon 13 expresses on the first intracellular loop four additional amino acid residues, EAVK, which alter ICl at low [Ca(2+)]i Exon 13 is expressed in 75-100% of Ano1 transcripts in most human tissues but only 25% in human stomach. Our aim was to determine the effect of EAVK deletion on Ano1(0) ICl parameters. By voltage-clamp electrophysiology, we examined ICl in HEK293 cells transiently expressing Ano1(0) with or without the EAVK sequence (Ano1(0)ΔEAVK). The EC50 values of activating and deactivating ICl for [Ca(2+)]i was 438±7 and 493±9 nM for Ano1(0) but higher for Ano1(0)ΔEAVK at 746±47 and 761±26 nM, respectively. Meanwhile, the EC50 values for the ratio of instantaneous to steady-state ICl were not different between variants. Congruently, the time constant of activation was slower for Ano1(0)ΔEAVK than Ano1(0) currents at intermediate [Ca(2+)]i These results suggest that EAVK decreases the calcium sensitivity of Ano1(0) current activation and deactivation by slowing activation kinetics. Differential expression of EAVK in human stomach may function as a switch to increase sensitivity to [Ca(2+)]i via faster gating of Ano1.

  5. Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells.

    PubMed

    Guan, Lizhao; Song, Yan; Gao, Jian; Gao, Jianjun; Wang, KeWei

    2016-11-29

    ANO1, a calcium-activated chloride channel, has been reported to be amplified or overexpressed in tissues of several cancers. However, reports on its roles in tumor progression obtained from cancer cell lines are inconsistent, suggesting that the role of ANO1 in tumorigenesis is likely dependent on either its expression level or cell-type expressing ANO1. To investigate the biological roles of ANO1 in different tumor cells, we, in this study, selected several cancer cell lines and a normal HaCaT cell line with high expression levels of ANO1, and examined the function of ANO1 in these cells using approaches of lentiviral knockdown and pharmacological inhibition. We found that ANO1 knockdown significantly inhibited cell proliferation and induced cell apoptosis in either tumor cell lines or normal HaCaT cell line. Moreover, silencing ANO1 arrested cancer cells at G1 phase of cell cycle. Treatment with ANO1 inhibitor CaCCinh-A01 reduced cell viability in a dose-dependent manner. Furthermore, both ANO1 inhibitors CaCCinh-A01 and T16Ainh-A01 significantly suppressed cell migration. Our findings show that ANO1 overexpression promotes cancer cell proliferation and migration; and genetic or pharmacological inhibition of ANO1 induces apoptosis and cell cycle arrest at G1 phase in different types of epithelium-originated cancer cells.

  6. Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells

    PubMed Central

    Guan, Lizhao; Song, Yan; Gao, Jian; Gao, Jianjun; Wang, KeWei

    2016-01-01

    ANO1, a calcium-activated chloride channel, has been reported to be amplified or overexpressed in tissues of several cancers. However, reports on its roles in tumor progression obtained from cancer cell lines are inconsistent, suggesting that the role of ANO1 in tumorigenesis is likely dependent on either its expression level or cell-type expressing ANO1. To investigate the biological roles of ANO1 in different tumor cells, we, in this study, selected several cancer cell lines and a normal HaCaT cell line with high expression levels of ANO1, and examined the function of ANO1 in these cells using approaches of lentiviral knockdown and pharmacological inhibition. We found that ANO1 knockdown significantly inhibited cell proliferation and induced cell apoptosis in either tumor cell lines or normal HaCaT cell line. Moreover, silencing ANO1 arrested cancer cells at G1 phase of cell cycle. Treatment with ANO1 inhibitor CaCCinh-A01 reduced cell viability in a dose-dependent manner. Furthermore, both ANO1 inhibitors CaCCinh-A01 and T16Ainh-A01 significantly suppressed cell migration. Our findings show that ANO1 overexpression promotes cancer cell proliferation and migration; and genetic or pharmacological inhibition of ANO1 induces apoptosis and cell cycle arrest at G1 phase in different types of epithelium-originated cancer cells. PMID:27732935

  7. Distributed Computing for Seismic Data Retrieval using FISSURES DHI Client FMI Implimented from MatSeis 1.9

    NASA Astrophysics Data System (ADS)

    Hart, D. M.; Li, Q.; Creager, K. C.; Ning, R.; Crotwell, H. P.; Zuzlewski, S.; Hellman, S. B.; Schoch, K. S.; Laughbon, C. J.; Stromme, S. R.

    2004-12-01

    Three software development efforts have recently combined to allow a seamless method for obtaining data from the IRIS DMC over the Internet and analyzing it in MATLAB. During the past few years IRIS has constructed the initial framework and definitions for FISSURES servers and Data Handling Interface (DHI) clients. FISSURES uses the distributed computing language Common Object Request Broker Architecture (CORBA), which allows software systems to work across the Internet in a platform independent and computer-language neutral manner. Starting from the FISSURES object model three seismic services have been defined: event, network and seismogram. From these three object types a DHI client is used to access information through FISSURES services. Using the University of Washington developed FISSURES-Matlab-Interface (FMI) DHI client, all three FISSURES objects can be accessed via the Internet and downloaded into local MATLAB objects, allowing access to earthquake event catalogs, seismograms, network and instrument information. The DHI client FMI can be implemented from MatSeis. MatSeis, developed at Sandia National Laboratory, is a MATLAB based, Graphical User Interface (GUI) controlled software package with seismic data visualization, signal processing, and database importing and exporting capabilities, to list just a few. In this poster, we will discuss the seismic data retrieval currently prototyped for the IRIS DMC, as well as the planned connections to the Northern California Earthquake Data Center (NCEDC), Southern California Earthquake Data Center (SCEDC), and South Carolina Earth Physics Project (SCEPP) data center.

  8. Attempts at in vitro fertilization and culture of in vitro matured oocytes in sei ( Balaenoptera borealis) and Bryde's ( B. edeni) whales.

    PubMed

    Bhuiyan, M M U; Suzuki, Y; Watanabe, H; Matsuoka, K; Fujise, Y; Ishikawa, H; Ohsumi, S; Fukui, Y

    2009-02-01

    The cumulus-oocyte-complexes (COCs) recovery rates with respect to reproductive status per sei (Balaenoptera borealis) and Bryde's (B. edeni) whales were determined in Experiment 1. The number of COCs recovered ranged from 16.0 to 30.6 and from 6.7 to 26.8 per sei and Bryde's whales, respectively. The effects of COCs grades and protein supplementation in embryo culture medium on development of in vitro fertilized (IVF) embryos were evaluated in sei and Bryde's whales in Experiment 2. The COCs were classified into either Grade A (COCs with five or more layers of compact cumulus cells) or Grade B (COCs with less than five layers of compact or expanded cumulus cells) before being cultured for IVM. The cleavage (12.0 to 19.5%), 4-cell (8.0 to 12.0%) and 8-cell (4.0 to 8.0%) formation rates in sei whales did not vary significantly between embryos derived from either grade A or B oocytes and between embryos cultured in either fetal whale serum (FWS)- or bovine serum albumin (BSA)-supplemented medium. The cleavage (4.0 to 14.8%), 4-cell (0.0 to 7.5%) and 8-cell (0.0 to 2.6%) formation rates in Bryde's whales did not vary significantly between embryos derived from either grade A or B oocytes and between embryos cultured in either FWS- or BSA-supplemented medium. The grade B oocytes cultured in FWS-supplemented medium developed to morula stage (1.1%) in sei whales. In conclusion, the present study indicates that IVF in sei whales is possible to achieve cleaved embryos developing to morula stage. This is the first in vitro embryo production attempt in sei and Bryde's whales.

  9. Mars deep internal structure determination using Phobos tide measurement strategy with the SEIS/InSight experiment

    NASA Astrophysics Data System (ADS)

    Pou, Laurent; Mimoun, David; Garcia, Raphaël; Lognonné, Philippe; Banerdt, William Bruce; Karatekin, Özgür; Dehant, Véronique; Zhu, Ping

    2016-04-01

    The Insight NASA Discovery mission, led by the Jet Propulsion Laboratory, will deploy in 2018 a very broadband seismometer on the Mars surface, SEIS (Seismic Experiment for Interior Structure). It is a hybrid 3-axes instrument, which encloses 3 very broadband oblique sensors and 3 short period sensors. The sensor assembly and its wind and thermal shield will by deployed on the Mars surface from the Phoenix-like spacecraft by a robotic arm (IDS). The acquisition system will be hosted in the spacecraft warm electronics box, and connected to the deployed sensor assembly by a tether. The SEIS experiment is provided by CNES, the French Space Agency that makes the coordination of a wide consortium including IPGP of Paris, ETH of Zürich, the Jet Propulsion Laboratory of Pasadena, MPS of Göttingen, Imperial College of London, and ISAE from Toulouse. One of the mission goals is to determine the deep internal structure of Mars in order to improve our models on the formation and evolution of telluric planets. In particular, the SEIS experiment aims at assessing the state (solid or liquid) of the planet core together with its size. This will be possible using the Phobos tide, a solid tide on Mars induced by one of its natural satellite, Phobos. As it orbits the planet, Phobos creates a small displacement of the Martian surface which will be measured to determine the absolute amplitude of one of the tide main harmonics which depends on Mars internal structure through the gravimetric factor γ2 (a combination of the gravitational and displacement Love numbers) at a frequency range around 50 μHz. Since Phobos orbital properties are already well-known, comparing these measurements with existing proposed models of Mars allows us to refine the previous estimations of the Mars core state and diameter. Reliable assessment of the core state will be possible if the Phobos tide absolute amplitude is measured with a precision of 2.5 10-11 m/s2 at 50μHz, making noise determination and

  10. Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

    PubMed Central

    Zhu, Jinqiu; Qu, Zhiqiang; Cui, Yuan-Yuan; Hartzell, H. Criss

    2014-01-01

    The Ca2+-activated Cl channel anoctamin-1 (Ano1; Tmem16A) plays a variety of physiological roles, including epithelial fluid secretion. Ano1 is activated by increases in intracellular Ca2+, but there is uncertainty whether Ca2+ binds directly to Ano1 or whether phosphorylation or additional Ca2+-binding subunits like calmodulin (CaM) are required. Here we show that CaM is not necessary for activation of Ano1 by Ca2+ for the following reasons. (a) Exogenous CaM has no effect on Ano1 currents in inside-out excised patches. (b) Overexpression of Ca2+-insensitive mutants of CaM have no effect on Ano1 currents, whereas they eliminate the current mediated by the small-conductance Ca2+-activated K+ (SK2) channel. (c) Ano1 does not coimmunoprecipitate with CaM, whereas SK2 does. Furthermore, Ano1 binds very weakly to CaM in pull-down assays. (d) Ano1 is activated in excised patches by low concentrations of Ba2+, which does not activate CaM. In addition, we conclude that reversible phosphorylation/dephosphorylation is not required for current activation by Ca2+ because the current can be repeatedly activated in excised patches in the absence of ATP or other high-energy compounds. Although Ano1 is blocked by the CaM inhibitor trifluoperazine (TFP), we propose that TFP inhibits the channel in a CaM-independent manner because TFP does not inhibit Ano1 when applied to the cytoplasmic side of excised patches. These experiments lead us to conclude that CaM is not required for activation of Ano1 by Ca2+. Although CaM is not required for channel opening by Ca2+, work of other investigators suggests that CaM may have effects in modulating the biophysical properties of the channel. PMID:24420770

  11. A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity.

    PubMed

    Hammer, Christian; Wanitchakool, Podchanart; Sirianant, Lalida; Papiol, Sergi; Monnheimer, Mathieu; Faria, Diana; Ousingsawat, Jiraporn; Schramek, Natalie; Schmitt, Corinna; Margos, Gabriele; Michel, Angelika; Kraiczy, Peter; Pawlita, Michael; Schreiber, Rainer; Schulz, Thomas F; Fingerle, Volker; Tumani, Hayrettin; Ehrenreich, Hannelore; Kunzelmann, Karl

    2015-02-23

    In a first genome-wide association study (GWAS) approach to anti-Borrelia seropositivity, we identified two significant single nucleotide polymorphisms (SNPs) (rs17850869, P = 4.17E-09; rs41289586, P = 7.18E-08). Both markers, located on chromosomes 16 and 3, respectively, are within or close to genes previously connected to spinocerebellar ataxia. The risk SNP rs41289586 represents a missense variant (R263H) of anoctamin 10 (ANO10), a member of a protein family encoding Cl(-) channels and phospholipid scramblases. ANO10 augments volume-regulated Cl(-) currents (IHypo) in Xenopus oocytes, HEK293 cells, lymphocytes and macrophages and controls volume regulation by enhancing regulatory volume decrease (RVD). ANO10 supports migration of macrophages and phagocytosis of spirochetes. The R263H variant is inhibitory on IHypo, RVD and intracellular Ca(2+) signals, which may delay spirochete clearance, thereby sensitizing adaptive immunity. Our data demonstrate for the first time that ANO10 has a central role in innate immune defense against Borrelia infection.

  12. Next generation sequencing on patients with LGMD and nonspecific myopathies: Findings associated with ANO5 mutations

    PubMed Central

    Savarese, Marco; Di Fruscio, Giuseppina; Tasca, Giorgio; Ruggiero, Lucia; Janssens, Sandra; De Bleecker, Jan; Delpech, Marc; Musumeci, Olimpia; Toscano, Antonio; Angelini, Corrado; Sacconi, Sabrina; Santoro, Lucio; Ricci, Enzo; Claes, Kathleen; Politano, Luisa; Nigro, Vincenzo

    2015-01-01

    We studied 786 undiagnosed patients with LGMD or nonspecific myopathic features to investigate the role of ANO5 mutations in limb-girdle muscular dystrophies (LGMDs) and in nonspecific myopathies using the next generation sequencing (NGS) approach. In 160 LGMD patients, we first sequenced hotspot exons 5 and 20 and then sequenced the remaining part of the coding region. Another 626 patients, recruited using broader inclusion criteria, were directly analyzed by targeted NGS. By combining NGS and Sanger sequencing, we identified 33/786 (4%) patients carrying putative pathogenic changes in both alleles and 23 ANO5 heterozygotes (3%). The phenotypic spectrum is broader than expected, from hyperCKemia to myopathies, with lack of genotype/phenotype correlations. In particular, this is currently the largest screening of the ANO5 gene. The large number of heterozygotes for damaging mutations suggests that anoctaminopathies should be frequent and often nonpenetrant. We propose the multiple genetic testing by targeted NGS as a first step to analyze patients with nonspecific myopathic presentations. This represents a straightforward approach to overcome the difficulties of clinical heterogeneity of ANO5 patients, and to test, at the same time, many other genes involved in neuromuscular disorders. PMID:25891276

  13. The Phenotypic Spectrum of DYT24 Due to ANO3 Mutations

    PubMed Central

    Stamelou, Maria; Charlesworth, Gavin; Cordivari, Carla; Schneider, Susanne A; Kägi, Georg; Sheerin, Una-Marie; Rubio-Agusti, Ignacio; Batla, Amit; Houlden, Henry; Wood, Nicholas W; Bhatia, Kailash P

    2014-01-01

    Genes causing primary dystonia are rare. Recently, pathogenic mutations in the anoctamin 3 gene (ANO3) have been identified to cause autosomal dominant craniocervical dystonia and have been assigned to the dystonia locus dystonia-24 (DYT24). Here, we expand on the phenotypic spectrum of DYT24 and provide demonstrative videos. Moreover, tremor recordings were performed, and back-averaged electroencephalography, sensory evoked potentials, and C-reflex studies were carried out in two individuals who carried two different mutations in ANO3. Ten patients from three families are described. The age at onset ranged from early childhood to the forties. Cervical dystonia was the most common site of onset followed by laryngeal dystonia. The characteristic feature in all affected individuals was the presence of tremor, which contrasts DYT24 from the typical DYT6 phenotype. Tremor was the sole initial manifestation in some individuals with ANO3 mutations, leading to misdiagnosis as essential tremor. Electrophysiology in two patients with two different mutations showed co-contraction of antagonist muscles, confirming dystonia, and a 6-Hz arm tremor at rest, which increased in amplitude during action. In one of the studied patients, clinically superimposed myoclonus was observed. The duration of the myoclonus was in the range of 250 msec at about 3 Hz, which is more consistent with subcortical myoclonus. In summary, ANO3 causes a varied phenotype of young-onset or adult-onset craniocervical dystonia with tremor and/or myoclonic jerks. Patients with familial cervical dystonia who also have myoclonus-dystonia as well as patients with prominent tremor and mild dystonia should be tested for ANO3 mutations. © 2014 The Authors. Movement Disorders published by International Parkinson and Movement Disorder Society PMID:24442708

  14. Connecting the irreversible capacity loss in Li-ion batteries with the electronic insulating properties of solid electrolyte interphase (SEI) components.

    DOE PAGES

    Leung, Kevin; Lin, Yu -Xiao; Liu, Zhe; ...

    2016-01-01

    The formation and continuous growth of a solid electrolyte interphase (SEI) layer are responsible for the irreversible capacity loss of batteries in the initial and subsequent cycles, respectively. In this article, the electron tunneling barriers from Li metal through three insulating SEI components, namely Li2CO3, LiF and Li3PO4, are computed by density function theory (DFT) approaches. Based on electron tunneling theory, it is estimated that sufficient to block electron tunneling. It is also found that the band gap decreases under tension while the work function remains the same, and thus the tunneling barrier decreases under tension and increases under compression.more » A new parameter, η, characterizing the average distances between anions, is proposed to unify the variation of band gap with strain under different loading conditions into a single linear function of η. An analytical model based on the tunneling results is developed to connect the irreversible capacity loss, due to the Li ions consumed in forming these SEI component layers on the surface of negative electrodes. As a result, the agreement between the model predictions and experimental results suggests that only the initial irreversible capacity loss is due to the self-limiting electron tunneling property of the SEI.« less

  15. Connecting the irreversible capacity loss in Li-ion batteries with the electronic insulating properties of solid electrolyte interphase (SEI) components

    NASA Astrophysics Data System (ADS)

    Lin, Yu-Xiao; Liu, Zhe; Leung, Kevin; Chen, Long-Qing; Lu, Peng; Qi, Yue

    2016-03-01

    The formation and continuous growth of a solid electrolyte interphase (SEI) layer are responsible for the irreversible capacity loss of batteries in the initial and subsequent cycles, respectively. In this article, the electron tunneling barriers from Li metal through three insulating SEI components, namely Li2CO3, LiF and Li3PO4, are computed by density function theory (DFT) approaches. Based on electron tunneling theory, it is estimated that sufficient to block electron tunneling. It is also found that the band gap decreases under tension while the work function remains the same, and thus the tunneling barrier decreases under tension and increases under compression. A new parameter, η, characterizing the average distances between anions, is proposed to unify the variation of band gap with strain under different loading conditions into a single linear function of η. An analytical model based on the tunneling results is developed to connect the irreversible capacity loss, due to the Li ions consumed in forming these SEI component layers on the surface of negative electrodes. The agreement between the model predictions and experimental results suggests that only the initial irreversible capacity loss is due to the self-limiting electron tunneling property of the SEI.

  16. SEI Formation and Interfacial Stability of a Si Electrode in a LiTDI-Salt Based Electrolyte with FEC and VC Additives for Li-Ion Batteries.

    PubMed

    Lindgren, Fredrik; Xu, Chao; Niedzicki, Leszek; Marcinek, Marek; Gustafsson, Torbjörn; Björefors, Fredrik; Edström, Kristina; Younesi, Reza

    2016-06-22

    An electrolyte based on the new salt, lithium 4,5-dicyano-2-(trifluoromethyl)imidazolide (LiTDI), is evaluated in combination with nano-Si composite electrodes for potential use in Li-ion batteries. The additives fluoroethylene carbonate (FEC) and vinylene carbonate (VC) are also added to the electrolyte to enable an efficient SEI formation. By employing hard X-ray photoelectron spectroscopy (HAXPES), the SEI formation and the development of the active material is probed during the first 100 cycles. With this electrolyte formulation, the Si electrode can cycle at 1200 mAh g(-1) for more than 100 cycles at a coulombic efficiency of 99%. With extended cycling, a decrease in Si particle size is observed as well as an increase in silicon oxide amount. As opposed to LiPF6 based electrolytes, this electrolyte or its decomposition products has no side reactions with the active Si material. The present results further acknowledge the positive effects of SEI forming additives. It is suggested that polycarbonates and a high LiF content are favorable components in the SEI over other kinds of carbonates formed by ethylene carbonate (EC) and dimethyl carbonate (DMC) decomposition. This work thus confirms that LiTDI in combination with the investigated additives is a promising salt for Si electrodes in future Li-ion batteries.

  17. Connecting the irreversible capacity loss in Li-ion batteries with the electronic insulating properties of solid electrolyte interphase (SEI) components.

    SciTech Connect

    Leung, Kevin; Lin, Yu -Xiao; Liu, Zhe; Chen, Long -Qing; Lu, Peng; Qi, Yue

    2016-01-01

    The formation and continuous growth of a solid electrolyte interphase (SEI) layer are responsible for the irreversible capacity loss of batteries in the initial and subsequent cycles, respectively. In this article, the electron tunneling barriers from Li metal through three insulating SEI components, namely Li2CO3, LiF and Li3PO4, are computed by density function theory (DFT) approaches. Based on electron tunneling theory, it is estimated that sufficient to block electron tunneling. It is also found that the band gap decreases under tension while the work function remains the same, and thus the tunneling barrier decreases under tension and increases under compression. A new parameter, η, characterizing the average distances between anions, is proposed to unify the variation of band gap with strain under different loading conditions into a single linear function of η. An analytical model based on the tunneling results is developed to connect the irreversible capacity loss, due to the Li ions consumed in forming these SEI component layers on the surface of negative electrodes. As a result, the agreement between the model predictions and experimental results suggests that only the initial irreversible capacity loss is due to the self-limiting electron tunneling property of the SEI.

  18. An Artificial SEI Enables the Use of A LiNi0.5Mn1.5O4 5 V Cathode with Conventional Electrolytes

    SciTech Connect

    Li, Juchuan; Baggetto, Loic; Martha, Surendra K; Veith, Gabriel M; Nanda, Jagjit; Liang, Chengdu; Dudney, Nancy J

    2013-01-01

    LiNi0.5Mn1.5O4 spinel is considered one of the most promising cathodes for advanced lithium ion batteries. However, the operation potential of LiNi0.5Mn1.5O4, ~4.75 V, is beyond the high voltage limit of the state-of-art electrolyte, ~4.3 V. Here, using thin films of LiNi0.5Mn1.5O4 as a model material, we show evidence that an artificial solid electrolyte interphase (SEI) enables the use of this 5 V cathode with conventional carbonate electrolytes. A thin coating of Lipon (lithium phosphorus oxynitride) as an artificial SEI on LiNi0.5Mn1.5O4 could remedy the decomposition of the electrolyte. The thickness of the Lipon artificial SEI is optimized by balancing the protection and additional resistance. The strategy of artificial SEI on cathodes is expected to enable the wide application of other high voltage cathodes for lithium ion batteries.

  19. Attitude of Academic Staff in Nigerian Tertiary Educational Institutions to Student Evaluation of Instruction (SEI): A Case Study of Cross River State University

    ERIC Educational Resources Information Center

    Idaka, Idaka I.; Joshua, Monday T.

    2009-01-01

    This study was designed to assess the attitude of academic staff in Nigerian tertiary educational institutions to student evaluation of instruction (SEI) and to find out the variable factors that influenced the expressed attitude of members of the academic staff, using Cross River State University as a case study. The study was a survey and so a…

  20. Wide-Angle Refraction Tomographic Inversion of Mid Cayman Spreading Center and its Oceanic Core Complex, CaySEIS Experiment

    NASA Astrophysics Data System (ADS)

    Harding, J.; Van Avendonk, H. J.; Hayman, N. W.; Grevemeyer, I.; Peirce, C.; Dannowski, A.; Papenberg, C. A.

    2015-12-01

    The CaySEIS experiment, conducted in April 2015, is a multi-national collaborative seismic study of the Mid Cayman Spreading Center (MCSC), an ultra-slow spreading center [15 mm/yr fr] in the Caribbean Sea. Ultra-slow spreading centers are thought to have very thin crust and a paucity of magmatism due to cooler mantle conditions. However, the suggestion that gabbro-cored oceanic core complexes (OCCs), volcanic deposits, and multiple layers of hydrothermal vents are widespread in the MCSC and other ultra-slow spreading centers has led to questions about the relationship between seafloor spreading rates and magmatism. To investigate this further, we conducted the CaySEIS experiment, with five wide-angle seismic refraction lines parallel and perpendicular to the neovolcanic zone. This analysis is based on two east-west oriented 100-km-long seismic refraction lines, which were each occupied by 18 ocean bottom seismometers. Line 2 lies across the central MCSC and an OCC called Mt. Dent. Line 3 crosses the northern end of the MCSC near the Oriente Transform Zone. With the wide-angle OBS data we can image the seismic velocity structure of Mt. Dent and distinguish between two models of OCCs - either Mt. Dent is composed of mostly gabbro with peridotite lenses identified by a low velocity gradient, or it is composed of mostly peridotite with gabbroic bodies identified by a constant velocity gradient. The crustal structure of both lines gives more insight into the asymmetry of the MCSC and the style of seafloor spreading to the east vs. the west. The 2-D velocity models reveal Mt. Dent has thick crust of 8 km with a low velocity gradient, supporting the magmatic gabbroic origin of OCCs. The surrounding crust to the west of the MCSC is highly variable, with areas of very thin crust. The crust to the east of the MCSC has an approximately constant thickness of 4 km. The development of OCCs may contribute to the crustal heterogeneity of ultra-slow spreading centers.

  1. InSight/SEIS@Mars Educational program : Sharing the InSight NASA mission and the Seismic Discovery of Mars with a International Network of classes

    NASA Astrophysics Data System (ADS)

    Lognonne, P. H.; Berenguer, J. L.; Sauron, A.; Denton, P.; Carrer, D.; Taber, J.; Bravo, T. K.; Gaboriaud, A.; Houston Jones, J.; Banerdt, W. B.; Martinuzzi, J. M.

    2015-12-01

    The InSIght mission will deploy in September 2016 a Geophysical Station on Mars, equipped with a suite of geophysical instruments, including 3 axis Very Broad Band Seismometer, 3 axis Short Period Seismometer, 3 axis Flux gate Magnetometer, Heat flow probe, geodetic beacon, infrasound/microbarometer, wind sensors and cameras. As for all NASA missions, Children and teenagers will be associated to the mission in the framework of the K12 InSight program, part of it being associated to the SEIS instrument.The two faces of the InSight/SEIS Education program are directed toward the promotion of Space Technologies and of Space Science.For Space technologies, this has already started with the InSight Elysium Educational project. The goal of the project, supported by CNES and performed by Technical High School near Toulouse, was the fabrication of a full scale mockup of the lander (see more at https://jeunes.cnes.fr/fr/elysium-le-jumeau-terrestre-dinsight ). The mockup was exhibited during the June, 2015 Paris air show. More than 300 students participated to the Elysium project.For Space Science, this will be made with the SEIS@Mars Educational project. Its plan is to transmit the SEIS data to a network of several hundred of middle and high schools worldwide, associated to existing "seismo(graph) at school" programs in the United States (https://www.iris.edu/hq/sis), France (www.edusismo.org) Switzerland (www.seismoatschool.ethz.ch) and United Kingdom (http://www.bgs.ac.uk/schoolseismology/). If the transmission of these data to the SEIS@school network will be automatic after their release by the NASA Planetary Data System, an earlier transmission will be made, especially after mid 2017, but also before through the integration of selected Schools to the project activities: the selected classrooms will perform the same activities as the project scientists. They will have to process rapidly the proprietary data in order to identify MarsQuake(s) and will be allowed to perform

  2. ANO10 mutations cause ataxia and coenzyme Q₁₀ deficiency.

    PubMed

    Balreira, Andrea; Boczonadi, Veronika; Barca, Emanuele; Pyle, Angela; Bansagi, Boglarka; Appleton, Marie; Graham, Claire; Hargreaves, Iain P; Rasic, Vedrana Milic; Lochmüller, Hanns; Griffin, Helen; Taylor, Robert W; Naini, Ali; Chinnery, Patrick F; Hirano, Michio; Quinzii, Catarina M; Horvath, Rita

    2014-11-01

    Inherited ataxias are heterogeneous disorders affecting both children and adults, with over 40 different causative genes, making molecular genetic diagnosis challenging. Although recent advances in next-generation sequencing have significantly improved mutation detection, few treatments exist for patients with inherited ataxia. In two patients with adult-onset cerebellar ataxia and coenzyme Q10 (CoQ10) deficiency in muscle, whole exome sequencing revealed mutations in ANO10, which encodes anoctamin 10, a member of a family of putative calcium-activated chloride channels, and the causative gene for autosomal recessive spinocerebellar ataxia-10 (SCAR10). Both patients presented with slowly progressive ataxia and dysarthria leading to severe disability in the sixth decade. Epilepsy and learning difficulties were also present in one patient, while retinal degeneration and cataract were present in the other. The detection of mutations in ANO10 in our patients indicate that ANO10 defects cause secondary low CoQ10 and SCAR10 patients may benefit from CoQ10 supplementation.

  3. MineSeis -- A MATLAB GUI program to calculate synthetic seismograms from a linear, multi-shot blast source model

    SciTech Connect

    Yang, X.

    1998-12-31

    Modeling ground motions from multi-shot, delay-fired mining blasts is important to the understanding of their source characteristics such as spectrum modulation. MineSeis is a MATLAB{reg_sign} (a computer language) Graphical User Interface (GUI) program developed for the effective modeling of these multi-shot mining explosions. The program provides a convenient and interactive tool for modeling studies. Multi-shot, delay-fired mining blasts are modeled as the time-delayed linear superposition of identical single shot sources in the program. These single shots are in turn modeled as the combination of an isotropic explosion source and a spall source. Mueller and Murphy`s (1971) model for underground nuclear explosions is used as the explosion source model. A modification of Anandakrishnan et al.`s (1997) spall model is developed as the spall source model. Delays both due to the delay-firing and due to the single-shot location differences are taken into account in calculating the time delays of the superposition. Both synthetic and observed single-shot seismograms can be used to construct the superpositions. The program uses MATLAB GUI for input and output to facilitate user interaction with the program. With user provided source and path parameters, the program calculates and displays the source time functions, the single shot synthetic seismograms and the superimposed synthetic seismograms. In addition, the program provides tools so that the user can manipulate the results, such as filtering, zooming and creating hard copies.

  4. Structure and functions of the placenta in common minke (Balaenoptera acutorostrata), Bryde's (B. brydei) and sei (B. borealis) whales.

    PubMed

    Kitayama, Chiyo; Sasaki, Motoki; Ishikawa, Hajime; Mogoe, Toshihiro; Ohsumi, Seiji; Fukui, Yutaka; Budipitojo, Teguh; Kondoh, Daisuke; Kitamura, Nobuo

    2015-01-01

    The structure and functions of placentas were examined in 3 species of rorqual whales, common minke (Balaenoptera acutorostrata), Bryde's (B. brydei) and sei (B. borealis) whales, with the aim of confirming the structural characteristics of the chorion, including the presence of the areolar part, and clarifying steroidogenic activities and fetomaternal interactions in the placentas of these whales. Placentas were collected from the second phase of the Japanese Whale Research Program under Special Permit in the North Pacific (JARPN II). Histological and ultrastructural examinations revealed that these whale placentas were epitheliochorial placentas with the interdigitation of chorionic villi lined by monolayer uninucleate cells (trophoblast cells) and endometrial crypts as well as folded placentation by fold-like chorionic villi. Moreover, well-developed pouch-like areolae were observed in the placentas, and active absorption was suggested in the chorionic epithelial cells of the areolar part (areolar trophoblast cells). Berlin blue staining showed the presence of ferric ions (Fe(3+)) in the uterine glandular epithelial cells and within the stroma of chorionic villi in the areolar part. An immunohistochemical examination revealed tartrate-resistant acid phosphatase (TRAP; known as uteroferrin in uteri) in the cytoplasm of glandular cells and areolar trophoblast cells. This result suggested that, in cetaceans, uteroferrin is used to supply iron to the fetus. Furthermore, immunoreactivity for P450scc and P450arom was detected in trophoblast cells, but not in areolar trophoblast cells, suggesting that trophoblast cells synthesize estrogen in whale placentas. Therefore, we herein immunohistochemically revealed the localization of aromatase and uteroferrin in cetacean placentas during pregnancy for the first time.

  5. Encefalitis por anticuerpos contra el receptor de NMDA: experiencia con seis pacientes pediátricos. Potencial eficacia del metotrexato

    PubMed Central

    Bravo-Oro, Antonio; Abud-Mendoza, Carlos; Quezada-Corona, Arturo; Dalmau, Josep; Campos-Guevara, Verónica

    2016-01-01

    Introducción La encefalitis por anticuerpos contra el receptor de N-metil-D-aspartato (NMDA) es una entidad cada vez más diagnosticada en edad pediátrica. A diferencia de los adultos, en muchos casos no se asocia a tumores y las manifestaciones iniciales en niños más frecuentes son crisis convulsivas y trastornos del movimiento, mientras que en los adultos predominan las alteraciones psiquiátricas. Casos clínicos Presentamos seis casos pediátricos confirmados con anticuerpos contra la subunidad NR1 del receptor de NMDA en suero y líquido cefalorraquídeo. Cinco de los casos comenzaron con crisis convulsivas como manifestación clínica inicial antes de desarrollar el cuadro clásico de esta entidad. En todos los casos se utilizaron esteroides como primera línea de tratamiento, con los que sólo se observó control de las manifestaciones en uno, por lo que el resto de los pacientes requirió inmunomoduladores de segunda línea. Todos los pacientes recibieron metotrexato como tratamiento inmunomodulador para evitar recaídas y la evolución fue a la mejoría en todos ellos. Conclusiones En nuestra serie de pacientes con encefalitis por anticuerpos contra el receptor de NMDA, ninguno se asoció a tumores. Todos los casos recibieron metotrexato por lo menos durante un año, no observamos eventos adversos clínicos ni por laboratorio, ni hubo secuelas neurológicas ni recaídas durante el tratamiento. Aunque es una serie pequeña y es deseable incrementar el número y tiempo de evolución, consideramos el metotrexato una excelente alternativa como tratamiento inmunomodulador para esta patología. PMID:24150952

  6. Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.

    PubMed

    Bill, Anke; Popa, M Oana; van Diepen, Michiel T; Gutierrez, Abraham; Lilley, Sarah; Velkova, Maria; Acheson, Kathryn; Choudhury, Hedaythul; Renaud, Nicole A; Auld, Douglas S; Gosling, Martin; Groot-Kormelink, Paul J; Gaither, L Alex

    2015-01-09

    The calcium-activated chloride channel ANO1 regulates multiple physiological processes. However, little is known about the mechanism of channel gating and regulation of ANO1 activity. Using a high-throughput, random mutagenesis-based variomics screen, we generated and functionally characterized ∼6000 ANO1 mutants and identified novel mutations that affected channel activity, intracellular trafficking, or localization of ANO1. Mutations such as S741T increased ANO1 calcium sensitivity and rendered ANO1 calcium gating voltage-independent, demonstrating a critical role of the re-entrant loop in coupling calcium and voltage sensitivity of ANO1 and hence in regulating ANO1 activation. Our data present the first unbiased and comprehensive study of the structure-function relationship of ANO1. The novel ANO1 mutants reported have diverse functional characteristics, providing new tools to study ANO1 function in biological systems, paving the path for a better understanding of the function of ANO1 and its role in health and diseases.

  7. Variomics Screen Identifies the Re-entrant Loop of the Calcium-activated Chloride Channel ANO1 That Facilitates Channel Activation*

    PubMed Central

    Bill, Anke; Popa, M. Oana; van Diepen, Michiel T.; Gutierrez, Abraham; Lilley, Sarah; Velkova, Maria; Acheson, Kathryn; Choudhury, Hedaythul; Renaud, Nicole A.; Auld, Douglas S.; Gosling, Martin; Groot-Kormelink, Paul J.; Gaither, L. Alex

    2015-01-01

    The calcium-activated chloride channel ANO1 regulates multiple physiological processes. However, little is known about the mechanism of channel gating and regulation of ANO1 activity. Using a high-throughput, random mutagenesis-based variomics screen, we generated and functionally characterized ∼6000 ANO1 mutants and identified novel mutations that affected channel activity, intracellular trafficking, or localization of ANO1. Mutations such as S741T increased ANO1 calcium sensitivity and rendered ANO1 calcium gating voltage-independent, demonstrating a critical role of the re-entrant loop in coupling calcium and voltage sensitivity of ANO1 and hence in regulating ANO1 activation. Our data present the first unbiased and comprehensive study of the structure-function relationship of ANO1. The novel ANO1 mutants reported have diverse functional characteristics, providing new tools to study ANO1 function in biological systems, paving the path for a better understanding of the function of ANO1 and its role in health and diseases. PMID:25425649

  8. Use and Organizational Effects of Measurement and Analysis in High Maturity Organizations: Results from the 2008 SEI State of Measurement and Analysis Practice Surveys

    DTIC Science & Technology

    2009-02-01

    comparisons can be found in Section 6.7. 36 | CMU/SEI-2008-TR-024 F re q u e n c y o f u s e 0.00 0.25 0.50 0.75 1.00 ML1 or DK ML2 ML3 ML4 or ML5...64 | CMU/SEI-2008-TR-024 V a lu e o f m e a s u re m e n t & a n a ly s is ( S 3 Q 1 ) 0.00 0.25 0.50 0.75 1.00 ML1 or DK ML2 ML3 ML4 or

  9. ANOS1: a unified nomenclature for Kallmann syndrome 1 gene (KAL1) and anosmin-1.

    PubMed

    de Castro, Fernando; Seal, Ruth; Maggi, Roberto

    2016-11-29

    It is accepted that confusion regarding the description of genetic variants occurs when researchers do not use standard nomenclature. The Human Genome Organization Gene Nomenclature Committee contacted a panel of consultants, all working on the KAL1 gene, to propose an update of the nomenclature of the gene, as there was a convention in the literature of using the 'KAL1' symbol, when referring to the gene, but using the name 'anosmin-1' when referring to the protein. The new name, ANOS1, reflects protein name and is more transferrable across species.

  10. Enterotoxin Gene Cluster-Encoded SEI and SElN from Staphylococcus aureus Isolates are Crucial for the Induction of Human Blood Cell Proliferation and Pathogenicity in Rabbits

    PubMed Central

    Roetzer, Andreas; Gruener, Corina S.; Haller, Guenter; Beyerly, John; Model, Nina; Eibl, Martha M.

    2016-01-01

    Among the toxin family of bacterial superantigens, the six members of the enterotoxin gene cluster (egc) seem to have unusual characteristics. They are present in the majority of Staphylococcus aureus strains, but their role in disease remains uncertain. We assessed secretion levels, immunogenicity, and toxicity of native and recombinant egc proteins. After having developed enzyme-linked immunosorbent assays, we found different quantities of egc proteins secreted by bacterial isolates. Supernatants induced proliferation of human peripheral blood mononuclear cells. However, purified recombinant egc proteins were shown to have differing superantigenicity potentials. Immunization with identical amounts of all members of egc, and the prominent toxic agent SEB, resulted in neutralizing antisera. Two egc proteins, SEI and SElN, were found to play a predominant role within the cluster. Both displayed the highest potential to activate blood cells, and were essential to be neutralized in supernatants. The application of a supernatant of a strain bearing only egc was sufficient for a lethal outcome in a rabbit model. Again, neutralization of SEI and SElN led to the survival of all tested animals. Finally, nanogram amounts of purified rSEI and rSElN led to lethality in vivo, pointing out the importance of both as virulence determinants among egc superantigens. PMID:27801832

  11. DigitSeis: A New Digitization Software and its Application to the Harvard-Adam Dziewoński Observatory Collection

    NASA Astrophysics Data System (ADS)

    Bogiatzis, P.; Altoé, I. L.; Karamitrou, A.; Ishii, M.; Ishii, H.

    2015-12-01

    DigitSeis is a new open-source, interactive digitization software written in MATLAB that converts digital, raster images of analog seismograms to readily usable, discretized time series using image processing algorithms. DigitSeis automatically identifies and corrects for various geometrical distortions of seismogram images that are acquired through the original recording, storage, and scanning procedures. With human supervision, the software further identifies and classifies important features such as time marks and notes, corrects time-mark offsets from the main trace, and digitizes the combined trace with an analysis to obtain as accurate timing as possible. Although a large effort has been made to minimize the human input, DigitSeis provides interactive tools for challenging situations such as trace crossings and stains in the paper. The effectiveness of the software is demonstrated with the digitization of seismograms that are over half a century old from the Harvard-Adam Dziewoński observatory that is still in operation as a part of the Global Seismographic Network (station code HRV and network code IU). The spectral analysis of the digitized time series shows no spurious features that may be related to the occurrence of minute and hour marks. They also display signals associated with significant earthquakes, and a comparison of the spectrograms with modern recordings reveals similarities in the background noise.

  12. A New Look at the Bathymetric and Potential-Field Structure of the Cayman Trough via CaySEIS

    NASA Astrophysics Data System (ADS)

    Hayman, N. W.; Harding, J.; Van Avendonk, H. J.; Peirce, C.; Grevemeyer, I.; Dannowski, A.; Papenberg, C. A.

    2015-12-01

    The Cayman Trough (CT) has one of the world's deepest axial valleys, thinnest crust, end-member basalt composition, and slowest spreading rate. Accommodating motion between the North American and Caribbean plates, and the Gonave microplate, marine magnetic anomalies show that the Mid-Cayman Spreading Center (MCSC) has been spreading at ~15 mm/yr (F.R.) since 20 Ma, if not 49 Ma. At a little over 100 km in length, the MCSC is now recognized to host oceanic core complexes (OCCs), hydrothermal vents, and a seafloor of variably distributed lower crustal gabbros, upper mantle peridotite/serpentinite, and basaltic lavas. Though spreading rate appears to be relatively symmetric over geologic time, the structure of the CT is quite asymmetric, with a broad region of low gravity and somewhat lineated magnetic anomalies to the east, and gravity highs and irregular magnetic anomalies to the west. Until now it has been difficult to further assess the nature of the CT because of the sparse and generally old data from the region; the CT's claim on thinnest crust, for example, stems primarily from pre-1960's seismic data and inferences from satellite gravity. The CaySEIS active-source OBS-experiment on the R/V Meteor thus set out in April of 2015 to provide a more complete, deeper view of the CT. A serendipitous discovery during the expedition is that the off-axis seafloor is characterized by curvilinear ridges preserving what appear to be dismembered OCCs. Thus, a previously proposed model based on the oblique volcanic ridge to the south of the axial OCC, Mt. Dent, could also apply to the geologic history of the CT. This model, which we call "the magmatic cleaver", envisions how intrusions cut the OCC surfaces and raft the hanging-wall-dominated portion of the OCC to the east, and the footwall-dominated portion to the west. The "cleaver" appears to have been operating over at least the last 20 Ma, illustrating how melt flow in ultraslow-spread crust can create distinctive

  13. Cusp Ion Fountain Observations from the e-POP Suprathermal Electron Imager (SEI) with DMSP and RISR-N conjunctions

    NASA Astrophysics Data System (ADS)

    Shen, Y.; Knudsen, D. J.; Burchill, J. K.; Howarth, A. D.; Yau, A. W.; Redmon, R. J.

    2015-12-01

    Low-energy (<10 eV) ion upflows associated with ambipolar ion acceleration in the cusp/cleft and polar cap regions are investigated using conjunctions of the Enhanced Polar Outflow Probe (e-POP) satellite, the Resolute Bay Incoherent Scatter Radar (RISR-N) and the DMSP satellites in June 2014. e-POP encountered the cusp/cleft ion fountain at 10-14 MLT and around 1000 km altitude during these experiments. Such intermediate-altitude observations of ion upflow have been sampled only rarely by previous satellite missions and ground-based radars. The Suprathermal Electron Imager (SEI) onboard e-POP measures two-dimensional ion distribution functions with a frame rate of 100 images per second, from which, high-precision energy and angle information of entering ions can be inferred. Large field-aligned ion bulk flow velocities (2.5 km/s) are estimated from the angle information with a resolution of the order of 25 m/s. The ion velocities were, in general, upward in the cusp region and downward in the polar cap region. The ion temperatures have been resolved by investigating the slop shape of the distribution function. It has been found that only weak perpendicular (to B) heating occurred during these events, which when combined with the simultaneous soft electron precipitation observed by the DMSP SSJ/4 instrument, suggests that ambipolar electric fields play a dominant role in accelerating ions upward at and below 1000 km. Also, structured DC field-aligned currents derived from the magnetic field instrument (MGF) onboard e-POP are found to be well-correlated with upflow velocities. In addition, ion composition information is available from e-POP's ion mass spectrometer (IRM). Oxygen ions (O+) were found to dominate (85%) in the identified events, accompanied by a small fraction (15%) of hydrogen ions (H+) and helium ions (He+). We will compare these in situ measurements with RISR-N observations in order to further our understanding of the mechanisms responsible for, and

  14. The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis.

    PubMed

    Ruppersburg, Chelsey Chandler; Hartzell, H Criss

    2014-06-01

    Many cells possess a single, nonmotile, primary cilium highly enriched in receptors and sensory transduction machinery that plays crucial roles in cellular morphogenesis. Although sensory transduction requires ion channels, relatively little is known about ion channels in the primary cilium (with the exception of TRPP2). Here we show that the Ca(2+)-activated Cl ((-)) channel anoctamin-1 (ANO1/TMEM16A) is located in the primary cilium and that blocking its channel function pharmacologically or knocking it down with short hairpin RNA interferes with ciliogenesis. Before ciliogenesis, the channel becomes organized into a torus-shaped structure ("the nimbus") enriched in proteins required for ciliogenesis, including the small GTPases Cdc42 and Arl13b and the exocyst complex component Sec6. The nimbus excludes F-actin and coincides with a ring of acetylated microtubules. The nimbus appears to form before, or independent of, apical docking of the mother centriole. Our data support a model in which the nimbus provides a scaffold for staging of ciliary components for assembly very early in ciliogenesis and chloride transport by ANO1/TMEM16A is required for the genesis or maintenance of primary cilia.

  15. The Ca2+-activated Cl− channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis

    PubMed Central

    Qu, Zhiqiang; Yao, Weicheng; Yao, Ruyong; Liu, Xiangping; Yu, Kuai; Hartzell, Criss

    2014-01-01

    Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca2+-activated Cl− channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment. PMID:24639373

  16. Ano1, a Ca2+-activated Cl− channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal

    PubMed Central

    Singh, Raman Deep; Gibbons, Simon J; Saravanaperumal, Siva Arumugam; Du, Peng; Hennig, Grant W; Eisenman, Seth T; Mazzone, Amelia; Hayashi, Yujiro; Cao, Chike; Stoltz, Gary J; Ordog, Tamas; Rock, Jason R; Harfe, Brian D; Szurszewski, Joseph H; Farrugia, Gianrico

    2014-01-01

    Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical activity to drive contractility in the gastrointestinal tract via ion channels. Ano1 (Tmem16a), a Ca2+-activated Cl− channel, is an ion channel expressed in ICC. Genetic deletion of Ano1 in mice resulted in loss of slow waves in smooth muscle of small intestine. In this study, we show that Ano1 is required to maintain coordinated Ca2+ transients between myenteric ICC (ICC-MY) of small intestine. First, we found spontaneous Ca2+ transients in ICC-MY in both Ano1 WT and knockout (KO) mice. However, Ca2+ transients within the ICC-MY network in Ano1 KO mice were uncoordinated, while ICC-MY Ca2+ transients in Ano1 WT mice were rhythmic and coordinated. To confirm the role of Ano1 in the loss of Ca2+ transient coordination, we used pharmacological inhibitors of Ano1 activity and shRNA-mediated knock down of Ano1 expression in organotypic cultures of Ano1 WT small intestine. Coordinated Ca2+ transients became uncoordinated using both these approaches, supporting the conclusion that Ano1 is required to maintain coordination/rhythmicity of Ca2+ transients. We next determined the effect on smooth muscle contractility using spatiotemporal maps of contractile activity in Ano1 KO and WT tissues. Significantly decreased contractility that appeared to be non-rhythmic and uncoordinated was observed in Ano1 KO jejunum. In conclusion, Ano1 has a previously unidentified role in the regulation of coordinated gastrointestinal smooth muscle function through coordination of Ca2+ transients in ICC-MY. PMID:25063822

  17. Modular condenser replacement at ANO-1 solves operating problems and improves performance

    SciTech Connect

    Edgell, D.; Davidian, A.

    1999-07-01

    After 22 years of operation, the condenser tube bundles and waterboxes at Arkansas Nuclear One, Unit 1 (ANO-1) had deteriorated significantly, impairing operating performance, reducing condenser reliability and increasing maintenance cost. An extensive condition assessment performed in 1995 revealed a 34% wall loss on the original Admiralty tubing and an erosion rate of 1.7% annually. Additionally, Arkansas Nuclear One was considering an 8% power uprate, which would place additional duty on the main condenser. As a result, it was decided to completely reconstruct the four condenser tube bundles serving the two low-pressure turbines at Arkansas Nuclear One. An evaluation of the available condenser tube materials was performed to determine which material was best suited for service in the single pass, single pressure condenser at ANO-1. All copper based materials were excluded from consideration due to the detrimental effect copper has on secondary chemistry and more specifically steam generator integrity. Titanium and a variety of stainless steel materials were evaluated, and ultimately titanium was selected as the replacement condenser tube material for the rebuilt condenser tube bundles due primarily to its corrosion resistance and extensive operating experience in condenser service. An impressed current cathodic protection system and epoxy waterbox coating was also installed to prevent galvanic corrosion of the carbon steel waterboxes. The cathodic protection system included local alarm indication to alert plant operating staff of any system malfunction that could result in titanium hydrating. A comparison of the heat transfer characteristics of the existing condenser design with Admiralty tubes and a new tube bundle design with titanium tubes concluded that a new tube bundle design was required to optimize the condenser performance and accommodate the anticipated 8% power uprate. This paper will discuss the condenser optimization program from the design state to

  18. Three novel ANO5 missense mutations in Caucasian and Chinese families and sporadic cases with gnathodiaphyseal dysplasia

    PubMed Central

    Jin, Lingling; Liu, Yi; Sun, Fanyue; Collins, Michael T.; Blackwell, Keith; Woo, Albert S.; Reichenberger, Ernst J.; Hu, Ying

    2017-01-01

    Gnathodiaphyseal dysplasia (GDD; MIM#166260) is an autosomal dominant syndrome with characteristic cemento-osseous lesions of jawbones, bone fragility, and diaphyseal sclerosis of tubular bones. To date, only five mutations in the proposed calcium-activated chloride channel ANO5/TMEM16E gene have been identified. In this study, we describe two families and two singular patients with three new mutations. One Caucasian family with seven affected members exhibited frequent bone fractures and florid osseous dysplasia (p.Cys356Tyr), while one Chinese family with two affected members suffered from cementoma and purulent osteomyelitis (p.Cys360Tyr). In addition, two different novel mutations (p.Gly518Glu and p.Arg215Gly) were identified in sporadic patients without family history. In vitro studies overexpressing GDD mutations (p.Cys356Tyr and p.Cys360Tyr) showed significantly reduced ANO5 protein. It appears that all GDD mutations known so far locate in an extracellular domain following the first transmembrane domain or in the 4th putative transmembrane domain. Both wild-type and mutant ANO5 protein localize to the endoplasmic reticulum. After Ano5 gene knock-down with shRNA in MC3T3-E1 osteoblast precursors we saw elevated expression of osteoblast-related genes such as Col1a1, osteocalcin, osterix and Runx2 as well as increased mineral nodule formation in differentiating cells. Our data suggest that ANO5 plays a role in osteoblast differentiation. PMID:28176803

  19. Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion.

    PubMed

    Xu, Zhixiong; Lefevre, Gaelle M; Gavrilova, Oksana; Foster St Claire, Mark B; Riddick, Gregory; Felsenfeld, Gary

    2014-11-25

    We used circular chromatin conformation capture (4C) to identify a physical contact in human pancreatic islets between the region near the insulin (INS) promoter and the ANO1 gene, lying 68 Mb away on human chromosome 11, which encodes a Ca(2+)-dependent chloride ion channel. In response to glucose, this contact was strengthened and ANO1 expression increased, whereas inhibition of INS gene transcription by INS promoter targeting siRNA decreased ANO1 expression, revealing a regulatory effect of INS promoter on ANO1 expression. Knockdown of ANO1 expression caused decreased insulin secretion in human islets, establishing a physical proximity-dependent feedback loop involving INS transcription, ANO1 expression, and insulin secretion. To explore a possible role of ANO1 in insulin metabolism, we carried out experiments in Ano1(+/-) mice. We observed reduced serum insulin levels and insulin-to-glucose ratios in high-fat diet-fed Ano1(+/-) mice relative to Ano1(+/+) mice fed the same diet. Our results show that determination of long-range contacts within the nucleus can be used to detect novel and physiologically relevant mechanisms. They also show that networks of long-range physical contacts are important to the regulation of insulin metabolism.

  20. Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer

    PubMed Central

    Jia, Linghan; Liu, Wen; Guan, Lizhao; Lu, Min; Wang, KeWei

    2015-01-01

    Lung cancer or pulmonary carcinoma is primarily derived from epithelial cells that are thin and line on the alveolar surfaces of the lung for gas exchange. ANO1/TMEM16A, initially identified from airway epithelial cells, is a member of Ca2+-activated Cl- channels (CaCCs) that function to regulate epithelial secretion and cell volume for maintenance of ion and tissue homeostasis. ANO1/TMEM16A has recently been shown to be highly expressed in several epithelium originated carcinomas. However, the role of ANO1 in lung cancer remains unknown. In this study, we show that inhibition of calcium-activated chloride channel ANO1/TMEM16A suppresses tumor growth and invasion in human lung cancer. ANO1 is upregulated in different human lung cancer cell lines. Knocking-down ANO1 by small hairpin RNAs inhibited proliferation, migration and invasion of GLC82 and NCI-H520 cancel cells evaluated by CCK-8, would-healing, transwell and 3D soft agar assays. ANO1 protein is overexpressed in 77.3% cases of human lung adenocarcinoma tissues detected by immunohistochemistry. Furthermore, the tumor growth in nude mice implanted with GLC82 cells was significantly suppressed by ANO1 silencing. Taken together, our findings provide evidence that ANO1 overexpression contributes to tumor growth and invasion of lung cancer; and suppressing ANO1 overexpression may have therapeutic potential in lung cancer therapy. PMID:26305547

  1. Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion

    PubMed Central

    Xu, Zhixiong; Lefevre, Gaelle M.; Gavrilova, Oksana; Foster St. Claire, Mark B.; Riddick, Gregory; Felsenfeld, Gary

    2014-01-01

    We used circular chromatin conformation capture (4C) to identify a physical contact in human pancreatic islets between the region near the insulin (INS) promoter and the ANO1 gene, lying 68 Mb away on human chromosome 11, which encodes a Ca2+-dependent chloride ion channel. In response to glucose, this contact was strengthened and ANO1 expression increased, whereas inhibition of INS gene transcription by INS promoter targeting siRNA decreased ANO1 expression, revealing a regulatory effect of INS promoter on ANO1 expression. Knockdown of ANO1 expression caused decreased insulin secretion in human islets, establishing a physical proximity-dependent feedback loop involving INS transcription, ANO1 expression, and insulin secretion. To explore a possible role of ANO1 in insulin metabolism, we carried out experiments in Ano1+/− mice. We observed reduced serum insulin levels and insulin-to-glucose ratios in high-fat diet–fed Ano1+/− mice relative to Ano1+/+ mice fed the same diet. Our results show that determination of long-range contacts within the nucleus can be used to detect novel and physiologically relevant mechanisms. They also show that networks of long-range physical contacts are important to the regulation of insulin metabolism. PMID:25385647

  2. Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer.

    PubMed

    Jia, Linghan; Liu, Wen; Guan, Lizhao; Lu, Min; Wang, KeWei

    2015-01-01

    Lung cancer or pulmonary carcinoma is primarily derived from epithelial cells that are thin and line on the alveolar surfaces of the lung for gas exchange. ANO1/TMEM16A, initially identified from airway epithelial cells, is a member of Ca2+-activated Cl- channels (CaCCs) that function to regulate epithelial secretion and cell volume for maintenance of ion and tissue homeostasis. ANO1/TMEM16A has recently been shown to be highly expressed in several epithelium originated carcinomas. However, the role of ANO1 in lung cancer remains unknown. In this study, we show that inhibition of calcium-activated chloride channel ANO1/TMEM16A suppresses tumor growth and invasion in human lung cancer. ANO1 is upregulated in different human lung cancer cell lines. Knocking-down ANO1 by small hairpin RNAs inhibited proliferation, migration and invasion of GLC82 and NCI-H520 cancel cells evaluated by CCK-8, would-healing, transwell and 3D soft agar assays. ANO1 protein is overexpressed in 77.3% cases of human lung adenocarcinoma tissues detected by immunohistochemistry. Furthermore, the tumor growth in nude mice implanted with GLC82 cells was significantly suppressed by ANO1 silencing. Taken together, our findings provide evidence that ANO1 overexpression contributes to tumor growth and invasion of lung cancer; and suppressing ANO1 overexpression may have therapeutic potential in lung cancer therapy.

  3. Comparing Ksharasutra (Ayurvedic Seton) and open fistulotomy in the management of fistula-in-ano

    PubMed Central

    Dutta, Gouranga; Bain, Jayanta; Ray, Ajay Kumar; Dey, Soumedhik; Das, Nandini; Das, Biswanath

    2015-01-01

    Background: Most commonly practiced surgical “lay open” technique to treat fistula-in-ano (a common anorectal pathology) has high rate of recurrence and anal incontinence. Alternatively, a nonsurgical cost efficient treatment with Ksharasutra (cotton Seton coated with Ayurvedic medicines) has minimal complications. In our study, we have tried to compare these two techniques. Materials and Methods: A prospective randomized control study was designed involving patients referred to the Department of General Surgery in RG Kar Medical College, Kolkata, India, from January 2010 to September 2011. Results: Among 50 patients, 26 were in Ksharasutra and 24 were in fistulotomy group. 86% patients were male and 54% of the patients were in the fourth decade. About 74% fistulas are inter-sphincteric and 26% were of trans-sphincteric variety. Severe postoperative pain was more (7.7% vs. 25%) in fistulotomy group, while wound discharge was more associated with Ksharasutra group (15.3% vs. 8.3%). Wound scarring, bleeding, and infection rate were similar in both groups. Ksharasutra group took more time to heal (mean: 53 vs. 35.7 days, P = 0.002) despite reduced disruption to their routine work (2.7 vs. 15.5 days work off, P <0.001). Interestingly, pain experienced was less in Ksharasutra group, there was no open wound in contrast to fistulotomy and it was significantly cost effective (Rupees 166 vs. 464). Conclusion: Treatment of fistula-in-ano with Ksharasutra is a simple with low complications and minimal cost. PMID:26283840

  4. SM1.3 Seismic Centers Data Acquisition: an introduction to Antelope, EarthWorm, SeisComP and their usage around the world

    NASA Astrophysics Data System (ADS)

    Pesaresi, Damiano; Sleeman, Reinoud

    2010-05-01

    Many medium to big size seismic data centers around the world are facing the same question: which software to use to acquire seismic data in real-time? A home-made or a commercial one? Both choices have pros and cons. The in-house development of software usually requires an increased investment in human resources rather than a financial investment. However, the advantage of fully accomplishing your own needs could be put in danger when the software engineer quits the job! Commercial software offers the advantage of being maintained, but it may require both a considerable financial investment and training. The main seismic software data acquisition suites available nowadays are the public domain SeisComP and EarthWorm packages and the commercial package Antelope. Nanometrics, Guralp and RefTek also provide seismic data acquisition software, but they are mainly intended for single station/network acquisition. Antelope is a software package for real-time acquisition and processing of seismic network data, with its roots in the academic seismological community. The software is developed by Boulder Real Time Technology (BRTT) and commercialized by Kinemetrics. It is used by IRIS affiliates for off-line data processing and it is the main acquisition tool for the USArray program and data centers in Europe like the ORFEUS Data Center, OGS (Italy), ZAMG (Austria), ARSO (Slovenia) and GFU (Czech Republic). SeisComP was originally developed for the GEOFON global network to provide a system for data acquisition, data exchange (SeedLink protocol) and automatic processing. It has evolved into to a widely distributed, networked seismographic system for data acquisition and real-time data exchange over Internet and is supported by ORFEUS as the standard seismic data acquisition tool in Europe. SeisComP3 is the next generation of the software and was developed for the German Indonesian Tsunami Early Warning System (GITEWS). SeisComP is licensed by GFZ (free of charge) and

  5. Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca(2+) transients and slow waves in adult mouse small intestine.

    PubMed

    Malysz, John; Gibbons, Simon J; Saravanaperumal, Siva A; Du, Peng; Eisenman, Seth T; Cao, Chike; Oh, Uhtaek; Saur, Dieter; Klein, Sabine; Ordog, Tamas; Farrugia, Gianrico

    2017-03-01

    Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit(+) electrical pacemakers that express the Ano1/TMEM16A Ca(2+)-activated Cl(-) channel, whose functions in the gastrointestinal tract remain incompletely understood. In this study, an inducible Cre-LoxP-based approach was used to advance the understanding of Ano1 in ICC-MY of adult mouse small intestine. Kit(CreERT2/+);Ano1(Fl/Fl) mice were treated with tamoxifen or vehicle, and small intestines (mucosa free) were examined. Quantitative RT-PCR demonstrated ~50% reduction in Ano1 mRNA in intestines of conditional knockouts (cKOs) compared with vehicle-treated controls. Whole mount immunohistochemistry showed a mosaic/patchy pattern loss of Ano1 protein in ICC networks. Ca(2+) transients in ICC-MY network of cKOs displayed reduced duration compared with highly synchronized controls and showed synchronized and desynchronized profiles. When matched, the rank order for Ano1 expression in Ca(2+) signal imaged fields of view was as follows: vehicle controls>cKO(synchronized)>cKO(desynchronized). Maintenance of Ca(2+) transients' synchronicity despite high loss of Ano1 indicates a large functional reserve of Ano1 in the ICC-MY network. Slow waves in cKOs displayed reduced duration and increased inter-slow-wave interval and occurred in regular- and irregular-amplitude oscillating patterns. The latter activity suggested ongoing interaction by independent interacting oscillators. Lack of slow waves and depolarization, previously reported for neonatal constitutive knockouts, were also seen. In summary, Ano1 in adults regulates gastrointestinal function by determining Ca(2+) transients and electrical activity depending on the level of Ano1 expression. Partial Ano1 loss results in Ca(2+) transients and slow waves displaying reduced duration, while complete and widespread absence of Ano1 in ICC-MY causes lack of slow wave and desynchronized Ca(2+) transients.NEW & NOTEWORTHY The Ca(2+)-activated

  6. Strategy on removing oxygen impurity for crystal growth of one candidate Tl6SeI4 for room-temperature hard radiation detector(Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Lin, Wenwen; Liu, Zhifu; Churilov, Alexei V.; He, Yihui; Kim, Hadong; Cirignano, Leonard J.; Malliakas, Christos D.; Li, Hao; Stoumpos, Constantinos C.; Chung, Duck Young; Wessels, Bruce W.; Kanatzidis, Mercouri G.

    2016-09-01

    Thallium based chalcogenide and halide semiconductors such as Tl4HgI6, TlGaSe2, Tl6SeI4 and Tl6SI4 are promising materials for room-temperature hard radiation detection. They feature appropriate band gaps, high mass densities and facile growth technology. However, these materials are being plagued by the Tl oxides impurity from Tl precursor or Tl containing binary precursors, which leads to problems including tube breakage, parasitic nucleation and detector performance deterioration. In this work, we present a facile way to chemically reduce Tl oxidations, and then eliminate oxygen impurity by adding high-purity graphite powder during synthesis and crystal growth. We also further investigated the reactivity between Tl oxides and graphite. The detector performance of Tl6SeI4 crystal was dramatically improved after lowering/removing the oxygen impurities. This result not only indicates the significance of removing oxygen impurity for improving detector performance. Our results suggest that the chemical reduction method we developed by adding carbon powder during synthesis is highly effective in substantially reducing oxygen impurities from Tl containing materials.

  7. The proposed use of radiofrequency ablation for the treatment of fistula-in-ano.

    PubMed

    Keogh, Kenneth M; Smart, Neil J

    2016-01-01

    Fistula in ano is a very common presentation to colorectal clinic. Embarrassment due to the symptoms makes accurate estimations of incidence difficult. It is estimated that up to 40% of peri-anal abscess will be accompanied by or preceded by a fistula. Fistulae can be classified into simple fistulae that involve no or minimal sphincter muscle and complex, which involve significant amounts of the anal sphincter muscle, possibly with multiple tracts. For complex fistulae a seton suture is usually placed through the tract and out through the anus to form a loop allowing pockets of sepsis to drain internally and externally and a mature tract of fibrous tissue to develop. Following this period definitive fistula treatment is considered. This can involve a number of procedures that have tremendously varied success rates in the literature. The first stage of surgical treatment is often a core fistulectomy, which entails surgical removal of the tract. This may be followed by insertion of fibrin glue, a collagen plug or formation of a rotation skin flap from surrounding tissue in order to close the resultant tissue defect. All current treatments have a significant failure rate. If this wound breaks down the surgery can leave a large painful peri-anal wound that can lead to ongoing fistulation. Should this occur resiting of the seton will be required with the patient only getting back to square one after months of healing around the seton. In addition removing cores of fibrous tissue passing through the sphincter can threaten the sphincter function resulting in impaired continence. Having seen radiofrequency ablation used to close varicose veins the authors propose that one could use similar techniques to close a fibrous tract matured with a seton in order to close a fistula. The authors propose that a short length radiofrequency catheter could be used to treat fistula in ano. This would in theory be less painful with less tissue destruction. In addition there would be no

  8. Física e Arte nas Estações do Ano

    NASA Astrophysics Data System (ADS)

    Pessôa Queiroz, Glória; da Conceição Barbosa Lima, Maria; Navarro Vasconcellos das Mercês, Maria

    2004-12-01

    The paper deals with the subject of the Four Seasons, exploring elements of Science and the Art in order to motivate students or public of museums of science and technology to understand it from their current cultural experiences and of old times. Physics joins to Astronomy to explain the phenomenon, while the use of Music and Painting make possible the immersion in the subject in way to many trips to the imagination capable to awake emotions.A proposal didactic is presented and justified for some consensus of the research in the area of teaching-learning of science, since that related to the persistent alternative conceptions concerning the causes of the changes observed at the different times of the year until the qualitative modelling of phenomena that appeals three-dimensional pedagogical models. Such proposal was developed in the activity named " Hiper interesting Talk: The Four Seasons, Science and Art" in the first Sunday of August/2003 in the Museum of Astronomy, MAST. O artigo trata do tema das Estações do Ano, explorando elementos da Ciência e da Arte como forma de motivar estudantes ou público de museus de ciência e tecnologia a compreendê-lo a partir de vivências culturais atuais e de outras épocas. A Física se junta à Astronomia para explicar o fenômeno, enquanto a Música e a Pintura possibilitam a imersão no tema em meio a muitas viagens à imaginação capazes de despertar emoções.Uma proposta didática é apresentada e justificada por consensos das muitas pesquisas na área de ensino-aprendizagem de ciências, desde os que se referem às persistentes concepções alternativas acerca das causas das mudanças observadas nas diferentes épocas do ano até à modelagem qualitativa de fenômenos que recorre a modelos pedagógicos tridimensionais. Tal proposta foi desenvolvida na atividade "Bate papo Hiperinteressante: As Quatro Estações, Ciência e Arte" realizada no primeiro domingo do mês de agosto de 2003 no Museu de Astronomia.

  9. [Strategies on perianal abscess and fistula-in-ano: interpretation of the guidelines from USA and German].

    PubMed

    Ding, Shu-qing; Ding, Yi-jiang

    2012-12-01

    The Practice Parameters for the Management of Perianal Abscess and Fistula-in-ano from USA(2011) and German guidelines for anal abscess (2012) are based on the evidence and specialists consensus from colorectal field. Standardization of the anal abscess management may simplify the anal fistula treatment. This review is to concepts from other countries and guide the treatment in China.

  10. Effect of boric acid treatment on the secondary cycle at ANO-2. Final report

    SciTech Connect

    Siegwarth, D.P.; McNea, D.A.; Sawochka, S.G.

    1985-11-01

    Because of the rapid progression of denting at the steam generator upper support plates at Arkansas Nuclear One-Unit 2 (ANO-2), Arkansas Power and Light (AP and L) implemented boric acid treatment during the third fuel cycle. Minimal effects of boric acid on secondary cycle ionic transport were observed; however, indications of accelerated corrosion of copper alloys in portions of the cycle were noted. Since the primary-to-secondary hydrogen diffusion rate data did not conform to the relation expected based on laboratory studies with Alloy 600, hydrogen transport data could not be employed to conclusively demonstrate the effect of boric acid on steam generator corrosion. Assuming that the basic form of the diffusion relation remained the same during operation with and without boric acid, a net increase in corrosion-generated hydrogen transport appeared to result from the adoption of boric acid treatment. This increase may be attributable to an increase in secondary cycle copper alloy corrosion rates, although additional measurements would be required to confirm this hypothesis.

  11. Estudo comparativo entre estrelas centrais de nebulosas planetárias deficientes em hidrogênio

    NASA Astrophysics Data System (ADS)

    Marcolino, W. L. F.; de Araújo, F. X.

    2003-08-01

    Apresentamos neste trabalho o resultado de um estudo das principais características espectrais das estrelas centrais de nebulosas planetárias (ECNP) deficientes em hidrogênio. A origem e a evolução dessas estrelas ainda constitui um problema em aberto na evolução estelar. Geralmente esses objetos são divididos em [WCE], [WCL] e [WELS]. Os tipos [WCE] e [WCL] apresentam um espectro típico de uma estrela Wolf-Rayet carbonada de população I e as [WELS] apresentam linhas fracas de carbono e oxigênio em emissão. Existem evidências que apontam a seguinte sequência evolutiva : [WCL] = > [WCE] = > [WELS] = > PG 1159 (pré anã-branca). No entanto, tal cenário apresenta falhas como por exemplo a falta de ECNP entre os tipos [WCL] e [WCE]. Baseados em uma amostra de 24 objetos obtida no telescópio de 1.52m em La Silla, Chile (acordo ESO/ON), ao longo do ano 2000, apresentamos os resultados da comparação das larguras equivalentes de diversas linhas relevantes entre os tipos [WCL], [WCE] e [WELS]. Verificamos que nossos dados estão de acordo com a sequência evolutiva. Baseado nas linhas de C IV, conseguimos dividir pela primeira vez as [WELS] em dois grupos principais. Além disso, os dados reforçam a afirmação de que as [WCE] são as estrelas que possuem a maior temperatura entre as ECNP deficientes em hidrogênio. Discutimos ainda, a escassez de dados disponíveis na literatura e a necessidade da obtenção de parametros físicos para estes objetos.

  12. Small-scale spatial variability of sperm and sei whales in relation to oceanographic and topographic features along the Mid-Atlantic Ridge

    NASA Astrophysics Data System (ADS)

    Skov, H.; Gunnlaugsson, T.; Budgell, W. P.; Horne, J.; Nøttestad, L.; Olsen, E.; Søiland, H.; Víkingsson, G.; Waring, G.

    2008-01-01

    The 2004 Mid-Atlantic Ridge (MAR)-ECO expedition on the R.V. G.O. Sars provided the first opportunity to correlate oceanic distributions of cetaceans with synoptic acoustic (ADCP to 700 m depth, multi-beam echosounders) measurements of high-resolution, three-dimensional (3D) potential habitat (spatial scale<100 km). The identified habitat features were tested with independent observations from the Icelandic combined cetacean and redfish cruises in 2001 and 2003 using data from a 3D ocean general circulation model of the MAR region (Regional Oceans Modelling System (ROMS) model 5 km resolution). The spatial autocorrelation of sampled encounter rates of sperm Physeter macrocephalus and sei whales Balaenoptera borealis indicated scale-dependent variability in the distribution of both species. Despite the large area surveyed, the observations of both species exhibited a strong small-scale structure (range parameter 20-50 km), indicating affinities to cross-seamount or cross-frontal structures. Potential cross-seamount and cross-frontal habitat structures were derived from the acoustic transect data by analysing fine-scale gradients in the 3D flow patterns and bathymetry, including interactions between frontal and topographic parameters. PLS regression was used to determine the potential habitat drivers of sperm and sei whales, both during the G.O. Sars cruise and during the Icelandic cruises in 2001 and 2003. The selected parameters, which reflected flow gradients interacting with the steep topography, were finally applied for modelling the habitat suitability of both target species along the northern MAR using Ecological Niche Factor Analysis. The results suggest aggregations of sperm and sei whales along the MAR are primarily associated with fine-scale frontal processes interacting with the topography in the upper 100 m of the water column just north of the Sub-Polar Front (SPF) and the Charlie-Gibbs Fracture Zone (CGFZ). As moderate and high habitat suitabilities

  13. Life Cycle Assessment of the MBT plant in Ano Liossia, Athens, Greece

    SciTech Connect

    Abeliotis, Konstadinos; Kalogeropoulos, Alexandros; Lasaridi, Katia

    2012-01-15

    Highlights: Black-Right-Pointing-Pointer We model the operation of an MBT plant in Greece based on LCA. Black-Right-Pointing-Pointer We compare four different MBT operating scenarios (among them and with landfilling). Black-Right-Pointing-Pointer Even the current operation of the MBT plant is preferable to landfilling. Black-Right-Pointing-Pointer Utilization of the MBT compost and metals generates the most environmental gains. Black-Right-Pointing-Pointer Thermal exploitation of RDF improves further the environmental performance of the plant. - Abstract: The aim of this paper is the application of Life Cycle Assessment to the operation of the MBT facility of Ano Liossia in the region of Attica in Greece. The region of Attica is home to almost half the population of Greece and the management of its waste is a major issue. In order to explicitly analyze the operation of the MBT plant, five scenarios were generated. Actual operation data of the MBT plant for the year 2008 were provided by the region of Attica and the LCA modeling was performed via the SimaPro 5.1 software while impact assessment was performed utilizing the Eco-indicator'99 method. The results of our analysis indicate that even the current operation of the MBT plant is preferable to landfilling. Among the scenarios of MBT operation, the one with complete utilization of the MBT outputs, i.e. compost, RDF, ferrous and non-ferrous metals, is the one that generates the most environmental gains. Our analysis indicates that the exploitation of RDF via incineration is the key factor towards improving the environmental performance of the MBT plant. Our findings provide a quantitative understanding of the MBT plant. Interpretation of results showed that proper operation of the modern waste management systems can lead to substantial reduction of environmental impacts and savings of resources.

  14. The Multi-factor Predictive Seis &Gis Model of Ecological, Genetical, Population Health Risk and Bio-geodynamic Processes In Geopathogenic Zones

    NASA Astrophysics Data System (ADS)

    Bondarenko, Y.

    I. Goal and Scope. Human birth rate decrease, death-rate growth and increase of mu- tagenic deviations risk take place in geopathogenic and anthropogenic hazard zones. Such zones create unfavourable conditions for reproductive process of future genera- tions. These negative trends should be considered as a protective answer of the com- plex biosocial system to the appearance of natural and anthropogenic risk factors that are unfavourable for human health. The major goals of scientific evaluation and de- crease of risk of appearance of hazardous processes on the territory of Dnipropetrovsk, along with creation of the multi-factor predictive Spirit-Energy-Information Space "SEIS" & GIS Model of ecological, genetical and population health risk in connection with dangerous bio-geodynamic processes, were: multi-factor modeling and correla- tion of natural and anthropogenic environmental changes and those of human health; determination of indicators that show the risk of destruction structures appearance on different levels of organization and functioning of the city ecosystem (geophys- ical and geochemical fields, soil, hydrosphere, atmosphere, biosphere); analysis of regularities of natural, anthropogenic, and biological rhythms' interactions. II. Meth- ods. The long spatio-temporal researches (Y. Bondarenko, 1996, 2000) have proved that the ecological, genetic and epidemiological processes are in connection with de- velopment of dangerous bio-geophysical and bio-geodynamic processes. Mathemat- ical processing of space photos, lithogeochemical and geophysical maps with use of JEIS o and ERDAS o computer systems was executed at the first stage of forma- tion of multi-layer geoinformation model "Dnipropetrovsk ARC View GIS o. The multi-factor nonlinear correlation between solar activity and cosmic ray variations, geophysical, geodynamic, geochemical, atmospheric, technological, biological, socio- economical processes and oncologic case rate frequency, general and primary

  15. Quantification of landfill emissions to air: a case study of the Ano Liosia landfill site in the greater Athens area.

    PubMed

    Paraskaki, Ioanna; Lazaridis, Mihalis

    2005-06-01

    Fugitive pollutant emissions from municipal solid waste landfills have the potential to cause annoyance and health impacts in the surrounding residential areas. The overall objective of this research was to perform an assessment of fugitive pollutant emissions and a dispersion analysis downwind of a specific landfill site. The study was performed at the closed Ano Liosia landfill site which is located in the greater Athens area. The human exposure from priority to health-risk pollutants emitted from landfill, such as vinyl chloride and benzene, was estimated by the landfill gas emission LandGEM 2.01 software combined with the atmospheric long-term dispersion model ISC3-LT. The emission and meteorological conditions under which the models were applied referred to the worst-case scenario. This scenario was used for the evaluation of the maximum human exposure assessed beyond the Ano Liosia landfill towards the residential areas. The above scenario provides the minimum downwind distance of the health-risk zone which is calculated to be equal to 1.5 km from the landfill. Within this distance the assessed air pollutant concentration for several air pollutants was significantly above the World Health Organization reference lifetime exposure health criteria. Finally, the applied methodology was used in the Ano Liosia landfill, where atmospheric concentrations of pollutants measured in the field were compared with model predictions.

  16. PERFACT procedure to treat supralevator fistula-in-ano: A novel single stage sphincter sparing procedure

    PubMed Central

    Garg, Pankaj

    2016-01-01

    AIM: To prospectively perform the PERFACT procedure in supralevator anal fistula/abscess. METHODS: Magnetic resonance imaging was done preoperatively in all the patients. Proximal cauterization around the internal opening, emptying regularly of fistula tracts and curettage of tracts (PERFACT) was done in all patients with supralevator fistula or abscess. All types of anal fistula and/or abscess with supralevator extension, whether intersphincteric or transsphincteric, were included in the study. The internal opening along with the adjacent mucosa was electrocauterized. The resulting wound was left open to heal by secondary intention so as to heal (close) the internal opening by granulation tissue. The supralevator tract/abscess was drained and thoroughly curetted. It was regularly cleaned and kept empty in the postoperative period. The primary outcome parameter was complete fistula healing. The secondary outcome parameters were return to work and change in incontinence scores (Vaizey objective scoring system) assessed preoperatively and at 3 mo after surgery. RESULTS: Seventeen patients were prospectively enrolled and followed for a median of 13 mo (range 5-21 mo). Mean age was 41.1 ± 13.4 years, M:F - 15:2. Fourteen (82.4%) had a recurrent fistula, 8 (47.1%) had an associated abscess, 14 (82.4%) had multiple tracts and 5 (29.4%) had horseshoe fistulae. Infralevator part of fistula was intersphincteric in 4 and transsphincteric in 13 patients. Two patients were excluded. Eleven out of fifteen (73.3%) were cured and 26.7% (4/15) had a recurrence. Two patients with recurrence were reoperated on with the same procedure and one was cured. Thus, the overall healing rate was 80% (12/15). All the patients could resume normal work within 48 h of surgery. There was no deterioration in incontinence scores (Vaizey objective scoring system). This is the largest series of supralevator fistula-in-ano (SLF) published to date. CONCLUSION: PERFACT procedure is an effective single

  17. Activation of the Cl− Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor*

    PubMed Central

    Jin, Xin; Shah, Shihab; Liu, Yani; Zhang, Huiran; Lees, Meredith; Fu, Zhaojun; Lippiat, Jonathan D.; Beech, David J.; Sivaprasadarao, Asipu; Baldwin, Stephen A.; Zhang, Hailin; Gamper, Nikita

    2014-01-01

    We report that ANO1 (also known as TMEM16A) Ca2+-activated Cl− channels in small neurons from dorsal root ganglia are preferentially activated by particular pools of intracellular Ca2+. These ANO1 channels can be selectively activated by the G protein-coupled receptor (GPCR)-induced release of Ca2+ from intracellular stores, but not by Ca2+ influx through voltage-gated Ca2+ channels. This ability to discriminate between Ca2+ pools was achieved by the tethering of ANO1-containing plasma membrane domains, which also contained GPCRs such as bradykinin receptor-2 and protease-activated receptor-2, to juxtamembrane regions of the endoplasmic reticulum. Interaction of the C-terminus and the first intracellular loop of ANO1 with IP3R1 (inositol 1,4,5-trisphosphate receptor 1) contributed to the tethering. Disruption of membrane microdomains blocked the ANO1 and IP3R1 interaction and resulted in the loss of coupling between GPCR signaling and ANO1. The junctional signaling complex enabled ANO1-mediated excitation in response to specific Ca2+ signals rather than to global changes in intracellular Ca2+. PMID:23982204

  18. Predicting the occurrence of embolic events: an analysis of 1456 episodes of infective endocarditis from the Italian Study on Endocarditis (SEI)

    PubMed Central

    2014-01-01

    Background Embolic events are a major cause of morbidity and mortality in patients with infective endocarditis. We analyzed the database of the prospective cohort study SEI in order to identify factors associated with the occurrence of embolic events and to develop a scoring system for the assessment of the risk of embolism. Methods We retrospectively analyzed 1456 episodes of infective endocarditis from the multicenter study SEI. Predictors of embolism were identified. Risk factors identified at multivariate analysis as predictive of embolism in left-sided endocarditis, were used for the development of a risk score: 1 point was assigned to each risk factor (total risk score range: minimum 0 points; maximum 2 points). Three categories were defined by the score: low (0 points), intermediate (1 point), or high risk (2 points); the probability of embolic events per risk category was calculated for each day on treatment (day 0 through day 30). Results There were 499 episodes of infective endocarditis (34%) that were complicated by ≥ 1 embolic event. Most embolic events occurred early in the clinical course (first week of therapy: 15.5 episodes per 1000 patient days; second week: 3.7 episodes per 1000 patient days). In the total cohort, the factors associated with the occurrence of embolism at multivariate analysis were prosthetic valve localization (odds ratio, 1.84), right-sided endocarditis (odds ratio, 3.93), Staphylococcus aureus etiology (odds ratio, 2.23) and vegetation size ≥ 13 mm (odds ratio, 1.86). In left-sided endocarditis, Staphylococcus aureus etiology (odds ratio, 2.1) and vegetation size ≥ 13 mm (odds ratio, 2.1) were independently associated with embolic events; the 30-day cumulative incidence of embolism varied with risk score category (low risk, 12%; intermediate risk, 25%; high risk, 38%; p < 0.001). Conclusions Staphylococcus aureus etiology and vegetation size are associated with an increased risk of embolism. In left

  19. Recent advances in the Lesser Antilles observatories Part 1 : Seismic Data Acquisition Design based on EarthWorm and SeisComP

    NASA Astrophysics Data System (ADS)

    Saurel, Jean-Marie; Randriamora, Frédéric; Bosson, Alexis; Kitou, Thierry; Vidal, Cyril; Bouin, Marie-Paule; de Chabalier, Jean-Bernard; Clouard, Valérie

    2010-05-01

    Lesser Antilles observatories are in charge of monitoring the volcanoes and earthquakes in the Eastern Caribbean region. During the past two years, our seismic networks have evolved toward a full digital technology. These changes, which include modern three components sensors, high dynamic range digitizers, high speed terrestrial and satellite telemetry, improve data quality but also increase the data flows to process and to store. Moreover, the generalization of data exchange to build a wide virtual seismic network around the Caribbean domain requires a great flexibility to provide and receive data flows in various formats. As many observatories, we have decided to use the most popular and robust open source data acquisition systems in use in today observatories community : EarthWorm and SeisComP. The first is renowned for its ability to process real time seismic data flows, with a high number of tunable modules (filters, triggers, automatic pickers, locators). The later is renowned for its ability to exchange seismic data using the international SEED standard (Standard for Exchange of Earthquake Data), either by producing archive files, or by managing output and input SEEDLink flows. French Antilles Seismological and Volcanological Observatories have chosen to take advantage of the best features of each software to design a new data flow scheme and to integrate it in our global observatory data management system, WebObs [Beauducel et al., 2004]1, see the companion paper (Part 2). We assigned the tasks to the different softwares, regarding their main abilities : - EarthWorm first performs the integration of data from different heterogeneous sources; - SeisComP takes all this homogeneous EarthWorm data flow, adds other sources and produces SEED archives and SEED data flow; - EarthWorm is then used again to process this clean and complete SEEDLink data flow, mainly producing triggers, automatic locations and alarms; - WebObs provides a friendly human interface, both

  20. The Correlation of Tree Phenology with nest number of Orang Utan Sumatera (Pongo abelii) on Primary Forest, Resort Sei Betung, Gunung Leuser National Park

    NASA Astrophysics Data System (ADS)

    Hartini, K. S.; Patana, P.; Oktaviani, M.

    2017-03-01

    Food availability affect the orangutan activities, including activities to make nests. This study was conducted to determine the correlation between the phenology of trees with the number of nests made by orangutans in primary forest Resort Sei Betung, Gunung Leuser National Park. Multi linear regression was used in this study to determine the relation and correlation between phenology and the presence of orangutan nests on a track that has been created. It took over 6 months (March - August 2015). There were 15 orangutan nests found on the track during the study. The equation model was : = 27,649 -0,011X1-0,104X2-0,056X3, and there was no significant differences (sig >0,05). The value of R2 was 70,3%. It means that all predictors simultaneously explain 70,3% of the presence of orangutan’s nest, and there is an expected predictors that may be the most affect on nest presence. The season or the intensity of rain may consider as an expected predictor.

  1. MineSeis -- A MATLAB{reg_sign} GUI program to calculate synthetic seismograms from a linear, multi-shot blast source model

    SciTech Connect

    Yang, X.

    1998-04-01

    Large scale (up to 5 kt) chemical blasts are routinely conducted by mining and quarry industries around the world to remove overburden or to fragment rocks. Because of their ability to trigger the future International Monitoring System (IMS) of the Comprehensive Test Ban Treaty (CTBT), these blasts are monitored and studied by verification seismologists for the purpose of discriminating them from possible clandestine nuclear tests. One important component of these studies is the modeling of ground motions from these blasts with theoretical and empirical source models. The modeling exercises provide physical bases to regional discriminants and help to explain the observed signal characteristics. The program MineSeis has been developed to implement the synthetic seismogram modeling of multi-shot blast sources with the linear superposition of single shot sources. Single shot sources used in the modeling are the spherical explosion plus spall model mentioned here. Mueller and Murphy`s (1971) model is used as the spherical explosion model. A modification of Anandakrishnan et al.`s (1997) spall model is developed for the spall component. The program is implemented with the MATLAB{reg_sign} Graphical User Interface (GUI), providing the user with easy, interactive control of the calculation.

  2. SEI Software Engineering Education Directory.

    DTIC Science & Technology

    1987-02-01

    Systems: VAX-8600 Compiler Design CS 465 U P X T - Textbooks: Compiler Design Theory, Lewis , Rosenkrantz, Steams Systems: VAx-8600 Simulation Techniques...Corvallis, OR,- 97331 United States Degrees: BS, MS, PHD Contact: Prof. Lewis , Ted Professor (503) 754-3273 Courses: Software Design CS 319 U P R T...Software Engineering Laboratory CS247 B P E Y Systems: microcomputer (vanes) Stanford University (Entry 2); Terman Engineering Center; Department of

  3. Analysing the primacy of distance in the utilization of health services in the Ahafo-Ano South district, Ghana.

    PubMed

    Buor, Daniel

    2003-01-01

    Although the distance factor has been identified as key in the utilization of health services in rural areas of developing countries, it has been analysed without recourse to related factors of travel time and transport cost. Also, the influence of distance on vulnerable groups in utilization has not been an object of survey by researchers. This paper addresses the impact of distance on utilization, and how distance compares with travel time and transport cost that are related to it in the utilization of health services in the Ahafo-Ano South (rural) district in Ghana. The study, a cross-sectional survey, also identifies the position of distance among other important factors of utilization. A sample of 400, drawn through systematic random technique, was used for the survey. Data were analysed using the regression model and some graphic techniques. The main instruments used in data collection were formal (face-by-face) interview and a questionnaire. The survey finds that distance is the most important factor that influences the utilization of health services in the Ahafo-Ano South district. Other key factors are income, service cost and education. The effect of travel time on utilization reflects that of distance and utilization. Recommendations to reduce distance coverage, improve formal education and reduce poverty have been made.

  4. Structure and functions of the placenta in common minke (Balaenoptera acutorostrata), Bryde’s (B. brydei) and sei (B. borealis) whales

    PubMed Central

    KITAYAMA, Chiyo; SASAKI, Motoki; ISHIKAWA, Hajime; MOGOE, Toshihiro; OHSUMI, Seiji; FUKUI, Yutaka; BUDIPITOJO, Teguh; KONDOH, Daisuke; KITAMURA, Nobuo

    2015-01-01

    The structure and functions of placentas were examined in 3 species of rorqual whales, common minke (Balaenoptera acutorostrata), Bryde’s (B. brydei) and sei (B. borealis) whales, with the aim of confirming the structural characteristics of the chorion, including the presence of the areolar part, and clarifying steroidogenic activities and fetomaternal interactions in the placentas of these whales. Placentas were collected from the second phase of the Japanese Whale Research Program under Special Permit in the North Pacific (JARPN II). Histological and ultrastructural examinations revealed that these whale placentas were epitheliochorial placentas with the interdigitation of chorionic villi lined by monolayer uninucleate cells (trophoblast cells) and endometrial crypts as well as folded placentation by fold-like chorionic villi. Moreover, well-developed pouch-like areolae were observed in the placentas, and active absorption was suggested in the chorionic epithelial cells of the areolar part (areolar trophoblast cells). Berlin blue staining showed the presence of ferric ions (Fe3+) in the uterine glandular epithelial cells and within the stroma of chorionic villi in the areolar part. An immunohistochemical examination revealed tartrate-resistant acid phosphatase (TRAP; known as uteroferrin in uteri) in the cytoplasm of glandular cells and areolar trophoblast cells. This result suggested that, in cetaceans, uteroferrin is used to supply iron to the fetus. Furthermore, immunoreactivity for P450scc and P450arom was detected in trophoblast cells, but not in areolar trophoblast cells, suggesting that trophoblast cells synthesize estrogen in whale placentas. Therefore, we herein immunohistochemically revealed the localization of aromatase and uteroferrin in cetacean placentas during pregnancy for the first time. PMID:26096685

  5. Inhibition of cell proliferation by a selective inhibitor of the Ca{sup 2+}-activated Cl{sup -} channel, Ano1

    SciTech Connect

    Mazzone, Amelia; Eisenman, Seth T.; Strege, Peter R.; Yao, Zhen; Ordog, Tamas; Gibbons, Simon J.; Farrugia, Gianrico

    2012-10-19

    Highlights: Black-Right-Pointing-Pointer T16A{sub inh}-A01 blocked Ano1 currents in HEK cells expressing Ano1. Black-Right-Pointing-Pointer T16A{sub inh}-A01 reduced proliferation in ICC primary cultures and CFPAC-1 cell line. Black-Right-Pointing-Pointer T16A{sub inh}-A01 reduced proliferation of ICC in intact smooth muscle strips. -- Abstract: Background: Ion channels play important roles in regulation of cellular proliferation. Ano1 (TMEM16A) is a Ca{sup 2+}-activated Cl{sup -} channel expressed in several tumors and cell types. In the muscle layers of the gastrointestinal tract Ano1 is selectively expressed in interstitial cells of Cajal (ICC) and appears to be required for normal gastrointestinal slow wave electrical activity. However, Ano1 is expressed in all classes of ICC, including those that do not generate slow waves suggesting that Ano1 may have other functions. Indeed, a role for Ano1 in regulating proliferation of tumors and ICC has been recently suggested. Recently, a high-throughput screen identified a small molecule, T16A{sub inh}-A01 as a specific inhibitor of Ano1. Aim: To investigate the effect of the T16A{sub inh}-A01 inhibitor on proliferation in ICC and in the Ano1-expressing human pancreatic cancer cell line CFPAC-1. Methods: Inhibition of Ano1 was demonstrated by whole cell voltage clamp recordings of currents in cells transfected with full-length human Ano1. The effect of T16A{sub inh}-A01 on ICC proliferation was examined in situ in organotypic cultures of intact mouse small intestinal smooth muscle strips and in primary cell cultures prepared from these tissues. ICC were identified by Kit immunoreactivity. Proliferating ICC and CFPAC-1 cells were identified by immunoreactivity for the nuclear antigen Ki67 or EdU incorporation, respectively. Results: T16A{sub inh}-A01 inhibited Ca{sup 2+}-activated Cl{sup -} currents by 60% at 10 {mu}M in a voltage-independent fashion. Proliferation of ICC was significantly reduced in primary cultures

  6. Meta-Analyses of Microarray Datasets Identifies ANO1 and FADD as Prognostic Markers of Head and Neck Cancer

    PubMed Central

    Reddy, Ram Bhupal; Bhat, Anupama Rajan; James, Bonney Lee; Govindan, Sindhu Valiyaveedan; Mathew, Rohit; DR, Ravindra; Hedne, Naveen; Illiayaraja, Jeyaram; Kekatpure, Vikram; Khora, Samanta S.; Hicks, Wesley; Tata, Pramila; Kuriakose, Moni A.; Suresh, Amritha

    2016-01-01

    The head and neck squamous cell carcinoma (HNSCC) transcriptome has been profiled extensively, nevertheless, identifying biomarkers that are clinically relevant and thereby with translational benefit, has been a major challenge. The objective of this study was to use a meta-analysis based approach to catalog candidate biomarkers with high potential for clinical application in HNSCC. Data from publically available microarray series (N = 20) profiled using Agilent (4X44K G4112F) and Affymetrix (HGU133A, U133A_2, U133Plus 2) platforms was downloaded and analyzed in a platform/chip-specific manner (GeneSpring software v12.5, Agilent, USA). Principal Component Analysis (PCA) and clustering analysis was carried out iteratively for segregating outliers; 140 normal and 277 tumor samples from 15 series were included in the final analysis. The analyses identified 181 differentially expressed, concordant and statistically significant genes; STRING analysis revealed interactions between 122 of them, with two major gene clusters connected by multiple nodes (MYC, FOS and HSPA4). Validation in the HNSCC-specific database (N = 528) in The Cancer Genome Atlas (TCGA) identified a panel (ECT2, ANO1, TP63, FADD, EXT1, NCBP2) that was altered in 30% of the samples. Validation in treatment naïve (Group I; N = 12) and post treatment (Group II; N = 12) patients identified 8 genes significantly associated with the disease (Area under curve>0.6). Correlation with recurrence/re-recurrence showed ANO1 had highest efficacy (sensitivity: 0.8, specificity: 0.6) to predict failure in Group I. UBE2V2, PLAC8, FADD and TTK showed high sensitivity (1.00) in Group I while UBE2V2 and CRYM were highly sensitive (>0.8) in predicting re-recurrence in Group II. Further, TCGA analysis showed that ANO1 and FADD, located at 11q13, were co-expressed at transcript level and significantly associated with overall and disease-free survival (p<0.05). The meta-analysis approach adopted in this study has identified

  7. Recommendations from the AIA/SEI Workshop on Research Advances Required for Real-Time Software Systems in the 1990’s held at Pittsburgh, Pennsylvania on 13-14 September 1989

    DTIC Science & Technology

    1989-12-01

    decision making under a problem domain "* online planning - shipboard, in route, getting back, on-vehicle mission replanning "• low-level adaptive control...of an ultra-reliable underwater vehicle: "* fault tolerance "• vehicle online planning "• adaptive control "* data compression "* rule-based systems...SEI-89-SR-18 6.5 System Connectivity * As SPOc systems employ distributed processor architectures and themselves form part of even larger space

  8. Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna).

    PubMed

    Derakhshan, Ali Reza

    2016-06-08

    Most cases of chronic fissure do not respond to medical treatment. Razi and Ibn Sina were 2 of the best-known scientists of ancient Persia. The purpose of this study was to find out new scientific evidence in modern medicine about their recommendations, in order to find certain clues to conduct useful researches in the future. First, treatments of anal fissure mentioned by Razi and Ibn Sina were reviewed. Then, literature search was made in electronic databases including PubMed, Scopus, and Google Scholar. Management of anal fissure according to Razi's and Ibn Sina's practices is done based on 3 interventions: lifestyle modifications, drug treatments, and manual procedures. Almost all remedies suggested by Razi and Ibn Sina have shown their effects on fissure in ano via several mechanisms of action in many in vitro and in vivo studies; Still there is lack of human studies on the subject.

  9. New Constraints on Buried Triassic Basins of the Eastern North American Margin and Implications for Regional Tectonics from Reanalysis of SeisData6 Seismic Profile

    NASA Astrophysics Data System (ADS)

    Knapp, C. C.; Akintunde, O. M.; Knapp, J. H.

    2012-12-01

    The Eastern North American Margin (ENAM) is most significant due to the complexity and regional extent of this mature Mesozoic passive margin rift system encompassing: (1) a large volume and regional extent of related magmatism, (2) a preserved complete stratigraphic column that records the post-rift evolution in several basins, (3) preserved lithospheric-scale pre-rift structures including Paleozoic sutures, and (4) a wide-range of geological, geochemical, and geophysical studies both onshore and offshore. The short-lived but most voluminous magmatic event associated with the initiation of rifting, the Central Atlantic Magmatic Province (CAMP), is one of the most significant magmatic events in North America. The South Georgia Rift (SGR) basin is believed to be the largest and probably the most geologically complex Mesozoic graben of the ENAM formed during crustal extension associated with the breakup of Pangea and later opening of the North Atlantic Ocean. The separation of the African and North American plates, the formation of the Atlantic Ocean and the associated zones of weakness in eastern North America have been stated as the initial events in the breakup of Pangea. At least four major unanswered questions of regional tectonic significance derive from a previous study of the USGS SeisData6 seismic profile across the Coastal Plain of South East Georgia and are now addressed through reprocessing. These issues are: (1) the stratigraphy, structural composition, extent and thickness of this buried basin which have remained unknown, (2) whether or not the SGR basin is connected with the Riddleville and Dunbarton basins in Georgia and South Carolina, (3) whether or not the Augusta fault, an inferred crustal scale thrust fault which approximately represents the Piedmont-Coastal Plain boundary in Georgia and South Carolina, extends underneath the Coastal Plain sediments, and (4) weather there is evidence of CAMP basalt flows or sills within the SGR basin along this

  10. Seismic structure and crustal nature of the geological provinces off the SW Iberian margin: results of the NEAREST-SEIS wide-angle seismic survey

    NASA Astrophysics Data System (ADS)

    Sallares, V.; Martinez, S.; Gailler, A.; Gutscher, M.; Bartolome, R.; Gracia, E.; Diaz, J.

    2010-12-01

    The region offshore the SW Iberian margin hosts the present-day NW-SE plate convergence between the European and African Plates causing continuous seismic activity of moderate magnitude. In autumn 2008 a Spanish-French team carried out a wide-angle seismic survey in the area (NEAREST-SEIS cruise), in the framework of the EU-funded NEAREST project. During the survey two long profiles were acquired using a pool of 36 Ocean Bottom Seismometers (OBS), to provide information about the crustal structure and nature of the different geological provinces, and to reveal the deep geometry of the main fault interfaces. A total of 30 OBS were deployed along profile P1, which is 356 km long and trends NW-SE from the Tagus abyssal plain (TAP), crossing the Gorringe bank (GB), the Horseshoe abyssal plain (HAP) and the Coral Patch Ridge (CPR), up to the thrust-and-fold belt of the Seine abyssal plain (SAP). The inverted model along this profile show four different domains. In the TAP a 3-4 km-thick, low velocity sedimentary layer covers the basement, which shows a velocity >7 km/s just 2-3 km below its top, similarly to that of the basement outcropping in the Gorringe bank. In the HAP the sedimentary cover is thicker, showing an upper unit with low velocity corresponding to the Horseshoe gravitational unit, on top of a higher velocity lower unit, which may represent the highly consolidated Mesozoic sedimentary sequence, with a total thickness of 5 km. The basement shows the same velocity distribution as in TAP and GB, suggesting a common nature and origin. According to its seismic structure, we interpret this basement as highly serpentinized, exhumed mantle. In contrast, the CPR and SAP show evidences for the presence of a well-developed, 6-7 km-thick oceanic crust, underlying the sedimentary sequence. Profile P2 is 256 km long, and trends S-N from the easternmost SAP beyond the NW Moroccan margin, crossing the Gulf of Cadiz imbricated wedge and the Portimao bank ending at the

  11. Crustal nature and seismic structure of the geological provinces offshore the SW Iberia: Highlights of the NEAREST-SEIS wide-angle seismic survey

    NASA Astrophysics Data System (ADS)

    Martínez-Loriente, S.; Sallares, V.; Gailler, A.; Bartolome, R.; Gracia, E.; Gutscher, M.; Diaz, J.

    2011-12-01

    The SW Iberian margin hosts the present day NW-SE plate convergence between the European and African Plates at a rate of 4.5 mm/yr causing seismic activity of moderate magnitude. During fall 2008 and in the frame of the EU-funded NEAREST project, was carried out a wide-angle seismic survey (NEAREST-SEIS cruise) consisting in 2 profiles. The main objectives of the survey were to gather information about the geometry of the crust-mantle boundary, identify the nature of the different geological provinces, obtain the physical properties of the crust, and unveil the deep geometry of the interfaces between main faults. A total of 30 OBS were deployed along profile P1, which is 356 km long and trends NW-SE running from the Tagus Abyssal Plain (TAP), Gorringe Bank (GB), Horseshoe Abyssal Plain (HAP), Coral Patch Ridge (CPR), and finally reaching the thrust-and-fold belt of the Seine Abyssal Plain (SAP). The inverted model shows four well-differentiated domains in terms of seismic structure. In the TAP there is a 3-4 km-thick sediment layer with low velocity, lying above a basement showing a remarkably high velocity (< 7 km/s), similar to that of the basement outcropping in the GB. In the HAP the sedimentary cover is thicker, showing an uppermost unit with very low velocity corresponding to the Upper Miocene Horseshoe Gravitational Unit, on top of a higher velocity lower unit, which corresponds to the Mesozoic sedimentary sequence, with a total thickness of 5 km. The basement shows the same velocity distribution as in TAP and GB, suggesting a common nature and origin. According to its seismic structure, we interpret this basement as very serpentinized, exhumed upper mantle. In contrast, the CPR and SAP show evidence for the presence of a well-developed, 6-7 km-thick oceanic crust, underlying the 2-3 km thick Mesozoic and Neogene sedimentary sequence. Profile P2 is 256 km long and trends N-S, across the Iberian margin shelf, Portimao Bank, Gulf of Cadiz imbricated wedge and

  12. Seismic structure of the main geological provinces off the SW Iberian margin: first results from the NEAREST-SEIS wide-angle seismic survey

    NASA Astrophysics Data System (ADS)

    Sallarès, Valentí; Martínez-Loriente, Sara; Gailler, Audrey; Bartolomé, Rafael; Gutscher, Marc-André; Graindorge, David; Lia Grácia, Eulà; Díaz, Jordi

    2010-05-01

    The region offshore the SW Iberian margin hosts the present-day NW-SE plate convergence between the European and African Plates at a rate of 4.5 mm/yr, fact that causes continuous seismic activity of moderate magnitude. In autumn 2008 a Spanish-French team carried out a refraction and wide-angle reflection seismic survey in the area (NEAREST-SEIS cruise), in the framework of the EU, FP6-funded NEAREST project. During the survey two long seismic profiles were acquired using a pool of 36 Ocean Bottom Seismometers (OBS), with the objectives of providing information about the geometry of the crust-mantle boundary and the physical properties of the crust, revealing the deep geometry of the main fault interfaces, and identifying the nature of the basement and the limits of the different geological provinces in the region. A total of 30 OBS were deployed along profile P1, which is 356 km long and trends NW-SE from the Tagus abyssal plain (TAP), crossing the Gorringe bank (GB), the Horseshoe abyssal plain (HAP) and the Coral Patch Ridge (CPR), up to the thrust-and-fold belt of the Seine abyssal plain (SAP). The acquired data were modeled by joint refraction and reflection travel time inversion, following a layer-stripping strategy. The inverted model show four well-differentiated domains in terms of its seismic structure: In the TAP a 3-4 km-thick, low velocity sedimentary layer covers the basement, which shows a remarkably high velocity (>7 km/s), similar to that of the basement outcropping in the Gorringe bank. In the HAP the sedimentary cover is thicker, showing an upper unit with low velocity corresponding to the Horseshoe gravitational unit, on top of a higher velocity lower unit, which may represent the highly consolidated Mesozoic sedimentary sequence. The thickness of the two units together exceeds 5 km. The basement shows the same velocity distribution as in TAP and GB, suggesting a common nature and origin. According to its seismic structure, and considering that

  13. Electronic structure and spectroscopic properties of mixed sodium actinide oxides Na2AnO4 (An = U, Np, Pu, Am)

    NASA Astrophysics Data System (ADS)

    Kovács, Attila

    2017-03-01

    Multireference relativistic post-HF and DFT calculations have been performed on four Na2AnO4 (An = U, Np, Pu, Am) molecules. Beyond the electronic characteristics of the ground and excited electronic states, the molecular geometries and vibrational frequencies have been determined.

  14. AB310. SPR-37 Cholinergic excitatory motor responses in the colon are mediated through the calcium-activated chloride conductance Ano1

    PubMed Central

    Hwang, Sung Jin; Blair, Peter J.; Rock, Jason; Pardo, David; Sanders, Kenton M.; Ward, Sean M.

    2016-01-01

    Objective There is a growing body of evidence that gastrointestinal smooth muscle excitability is regulated by several different classes of interstitial cells [interstitial cells of Cajal (ICC) and PDGFRα(+) cells] that are electrically coupled to SMC. Thus, ‘myogenic’ activity results from the integrated behavior of the SMC/ICC/PDGFRα(+) cell (SIP) syncytium. Inputs from excitatory and inhibitory motor neurons are required to produce the complex motor patterns of the gut and coordinate GI motility. Motor neurons innervate these three cell types in the SIP syncytium, and receptors, second messenger pathways, and ion channels in these cells mediate postjunctional responses. Cholinergic neurotransmission in GI muscles from several species has long been thought to be dependent upon activation of a non-selective cation conductance in smooth muscle cells and the molecular candidates for mediating cholinergic excitation have been reported to be the transient receptor protein channels Trpc4 and Trpc6. However, we have shown that cholinergic responses in the GI tract involve ICC and in their absence these motor responses are greatly diminished or absent. We sought to determine the conductance(s) responsible for cholinergic motor responses in the colon. Methods Cre-LoxP recombinase technology was utilized to determine the role of the calcium-activated chloride conductance, Ano1 in post-junctional motor responses in the mouse colon in a cell-specific manner (Kit+ ICC). c-KitCreERT2/+ (Kit-Cre) mice and Ano f/f mice were crossed to generate c-KitCreERT2/+; Ano1f/f (mutants) and c-KitCreERT2/+; Ano1f/+ (controls) animals that were subsequently treated with tamoxifen to induce Cre recombinase expression in ICC. Confocal microscopy was used to determine the cell type Cre expression was switched on. Intracellular microelectrode recordings were performed to determine changes in post-junctional neural responses to nerve stimulation in c-KitCreERT2/+ (Kit-Cre) mice and Anof

  15. Revisiting an ancient treatment for transphincteric fistula-in-ano ‘There is nothing new under the sun’ Ecclesiastes 1v9

    PubMed Central

    Sturgeon, G; Hargest, R

    2015-01-01

    Objective The history of treatments for fistula-in-ano can be traced back to ancient times. Current treatment of transphincteric fistulae is controversial, with many options available. We reviewed the history of treatment using cutting setons and present our series of transphincteric fistulae in the light of the series in the literature. Design Literature review and case series. Setting Hospital based coloproctology service Participants 140 consecutive patients presenting with fistula-in-ano were included. Main Outcome Measures The literature pertaining to treatment of transphincteric fistula was reviewed, along with the outcome of various treatment methods for this condition. Data were collected for 140 consecutive patients presenting with fistula- in-ano were assessed for fistula healing, recurrence and complications. Results A total of 140 consecutive patients with fistula-in-ano were identified, of which 111 were cryptoglandular (79.3%). Eighty-one of these 111 were transphincteric (73.0%). At a median follow-up of 35 months (range, 2–83 months), 70 transphincteric fistulae had healed (86.4%), 10 were still undergoing treatment (12.3%) and one patient was lost to follow-up prior to treatment (1.2%). Two patients in this group required a stoma (2.5%), six patients developed recurrence (7.4%); three ‘true’ recurrences (3.7%). One (1.2%) developed a chronic fissure. There were no reported cases of incontinence. Conclusions The management of transphincteric fistula-in-ano is complex and controversial, for which no clear surgical procedure has gained acceptance as the gold standard. This study demonstrates that transphincteric fistulae can be successfully treated using cutting setons. A high healing rate (86.4%), low recurrence rate (7.4%) and a low complication rate (3.7%) are shown, which compares favourably with published rates over a long follow-up. PMID:26152674

  16. A comparative clinical study of Snuhi Ksheera Sutra, Tilanala Kshara Sutra and Apamarga Kshara Sutra in Bhagandara (Fistula in Ano)

    PubMed Central

    Lobo, Supreeth Joyal; Bhuyan, C.; Gupta, S. K.; Dudhamal, T. S.

    2012-01-01

    Bhagandara (Fistula in Ano) at modern parlance is a common anorectal condition prevalent in the populations worldwide and its prevalence is second highest after Arsha (hemorrhoids). Kshara Sutra (K.S.) is one of the chief modality in the treatment of Bhagandara in Ayurvedic science. Exploration of the new plants for the preparation of Kshara as a better substitute to Apamarga Kshara is the need of the hour. To find out an effective alternative to Apamarga K.S. in view of easy processing, a Snuhi Ksheera Sutra without any Kshara and the Tilanala K.S. were opted for their clinical evaluation. Total 33 cases of Bhagandara were divided randomly into 3 groups, having 11 patients in each group. In Group A, Snuhi Ksheera Sutra; in Group B, Tilanala K.S. and in Group C, Apamarga K.S. were used. Assessment was done on objective (Unit Cutting Time - UCT) and subjective parameters. Statistically insignificant difference was observed in the efficacy of treatment by subjective parameters like pain, discharge, etc. between the three groups. It was found that Tilanala K.S. showed higher UCT (9.76 days) while lower in Snuhi Ksheera Sutra (7.42 days) as compared to Apamarga K.S. (8.82 days). Thus Tilanala K.S. can be used as a substitute for Apamarga K.S. and Snuhi Ksheera Sutra can be employed in the recurrent fibrosed cases of Bhagandara. PMID:23049190

  17. The reactions of para-halo diaryl diselenides with halogens. A structural investigation of the CT compound (p-FC6H4)2Se2I2, and the first reported “RSeI3” compound, (p-ClC6H4)SeI·I2, which contains a covalent Se-I bond.

    PubMed

    Barnes, Nicholas A; Godfrey, Stephen M; Hughes, Jill; Khan, Rana Z; Mushtaq, Imrana; Ollerenshaw, Ruth T A; Pritchard, Robin G; Sarwar, Shamsa

    2013-02-28

    The reactions of the diaryl-diselenides (p-FC(6)H(4))(2)Se(2) and (p-ClC(6)H(4))(2)Se(2) with diiodine have been investigated. Species of stoichiometry "RSeI" are formed when the ratio employed is 1:1. The solid-state structure of "(p-FC(6)H(4))SeI" has been determined, and shown to be a charge-transfer (CT) adduct, (p-FC(6)H(4))(2)Se(2)I(2), where the Se-Se bond is retained and the diiodine molecule interacts with only one of the selenium atoms. The Se-I bond in (p-FC(6)H(4))(2)Se(2)I(2) is 2.9835(12) Å, which is typical for a (10-I-2) Se-I-I CT system. When diiodine is reacted in a 3:1 ratio with (p-XC(6)H(4))(2)Se(2) (X = F, Cl) species of stoichiometry "RSeI(3)" are formed. The structure of "(p-ClC(6)H(4))SeI(3)" reveals that this is not a selenium(IV) compound, but is better represented as a selenium(II) CT adduct, (p-ClC(6)H(4))SeI·I(2). The Se-I bond to the diiodine molecule is typical in magnitude for a CT adduct, Se-I: 2.8672(5) Å, whereas the other Se-I bond is much shorter, Se-I: 2.5590(6) Å, and is a genuine example of a rarely observed covalent Se-I bond, which appears to be stabilised by a weak Se···I interaction from a neighbouring iodine atom. The reaction of (p-ClC(6)H(4))SeI with Ph(3)P results in the formation of a CT adduct, Ph(3)PSe(p-ClC(6)H(4))I, which has a T-shaped geometry at selenium (10-Se-3). By contrast, the reaction of (p-FC(6)H(4))SeI with Ph(3)P does not form an adduct, but results in the formation of Ph(3)PI(2) and (p-FC(6)H(4))(2)Se(2).

  18. Computational Exploration of the Li-Electrode|Electrolyte Interface in the Presence of a Nanometer Thick Solid-Electrolyte Interphase Layer [Computational exploration of the Li-electrode|electrolyte interface complicated by a nanometer thin solid-electrolyte interphase (SEI) layer

    SciTech Connect

    Li, Yunsong; Leung, Kevin; Qi, Yue

    2016-09-30

    A nanometer thick passivation layer will spontaneously form on Li-metal in battery applications due to electrolyte reduction reactions. This passivation layer in rechargeable batteries must have “selective” transport properties: blocking electrons from attacking the electrolytes, while allowing Li+ ion to pass through so the electrochemical reactions can continue. The classical description of the electrochemical reaction, Li+ + e → Li0, occurring at the Li-metal|electrolyte interface is now complicated by the passivation layer and will reply on the coupling of electronic and ionic degrees of freedom in the layer. We consider the passivation layer, called “solid electrolyte interphase (SEI)”, as “the most important but the least understood in rechargeable Li-ion batteries,” partly due to the lack of understanding of its structure–property relationship. In predictive modeling, starting from the ab initio level, we find that it is an important tool to understand the nanoscale processes and materials properties governing the interfacial charge transfer reaction at the Li-metal|SEI|electrolyte interface. Here, we demonstrate pristine Li-metal surfaces indeed dissolve in organic carbonate electrolytes without the SEI layer. Based on joint modeling and experimental results, we point out that the well-known two-layer structure of SEI also exhibits two different Li+ ion transport mechanisms. The SEI has a porous (organic) outer layer permeable to both Li+ and anions (dissolved in electrolyte), and a dense (inorganic) inner layer facilitate only Li+ transport. This two-layer/two-mechanism diffusion model suggests only the dense inorganic layer is effective at protecting Li-metal in electrolytes. This model suggests a strategy to deconvolute the structure–property relationships of the SEI by analyzing an idealized SEI composed of major components, such as Li2CO3, LiF, Li

  19. Computational Exploration of the Li-Electrode|Electrolyte Interface in the Presence of a Nanometer Thick Solid-Electrolyte Interphase Layer [Computational exploration of the Li-electrode|electrolyte interface complicated by a nanometer thin solid-electrolyte interphase (SEI) layer

    DOE PAGES

    Li, Yunsong; Leung, Kevin; Qi, Yue

    2016-09-30

    A nanometer thick passivation layer will spontaneously form on Li-metal in battery applications due to electrolyte reduction reactions. This passivation layer in rechargeable batteries must have “selective” transport properties: blocking electrons from attacking the electrolytes, while allowing Li+ ion to pass through so the electrochemical reactions can continue. The classical description of the electrochemical reaction, Li+ + e → Li0, occurring at the Li-metal|electrolyte interface is now complicated by the passivation layer and will reply on the coupling of electronic and ionic degrees of freedom in the layer. We consider the passivation layer, called “solid electrolyte interphase (SEI)”, as “themore » most important but the least understood in rechargeable Li-ion batteries,” partly due to the lack of understanding of its structure–property relationship. In predictive modeling, starting from the ab initio level, we find that it is an important tool to understand the nanoscale processes and materials properties governing the interfacial charge transfer reaction at the Li-metal|SEI|electrolyte interface. Here, we demonstrate pristine Li-metal surfaces indeed dissolve in organic carbonate electrolytes without the SEI layer. Based on joint modeling and experimental results, we point out that the well-known two-layer structure of SEI also exhibits two different Li+ ion transport mechanisms. The SEI has a porous (organic) outer layer permeable to both Li+ and anions (dissolved in electrolyte), and a dense (inorganic) inner layer facilitate only Li+ transport. This two-layer/two-mechanism diffusion model suggests only the dense inorganic layer is effective at protecting Li-metal in electrolytes. This model suggests a strategy to deconvolute the structure–property relationships of the SEI by analyzing an idealized SEI composed of major components, such as Li2CO3, LiF, Li2O, and their mixtures. After sorting out the Li+ ion diffusion carriers and

  20. X-ray sterilization of the An. arabiensis genetic sexing strain 'ANO IPCL1' at pupal and adult stages.

    PubMed

    Ndo, C; Yamada, H; Damiens, D D; N'do, S; Seballos, G; Gilles, J R L

    2014-03-01

    With a view to area wide integrated pest management programs with a sterile insect technique (SIT) component against the malaria vector Anopheles arabiensis, the effects of X-ray exposure of males of the genetic sexing strain (GSS) of An. arabiensis, "ANO IPCL1" have been tested. The suitability of X-ray was assessed in comparison to gamma-ray for mosquito sterilization in operational settings where the acquisition of gamma ray irradiators may be problematic. Pupae and adult males were sterilized using X-ray irradiation at 5 increasing doses and effects were observed in terms of fecundity and fertility. Irradiated pupae and adults were further observed for effects on longevity. The adult stage appeared to be more sensitive to radiation exposure than the pupal stage, with a residual fertility of 1% in adults irradiated at 75Gy and 0% at 105Gy, compared to 8%at 75Gy and 4% at 105Gy in adults irradiated at the pupal stage. All treatment groups except those irradiated at 60Gy were statistically different from the control groups in terms of adult longevity post treatment, however overall survival was not highly compromised in the 75Gy treatment group which showed 96% of induced sterility. To ensure the fine balance between the induced sterility and the fitness of the insect produced is achieved, irradiation of adults at this dose may be a good compromise for the SIT as applied for this species, especially in specific cases such as sterilization after female elimination by spiking blood meals. Investigation into the combined effects of blood spiking and irradiation at the adult stage and additional competitiveness studies both in laboratory and field cages will provide more insight into the radiation dose and mosquito stage to be used in the frame of future SIT programs targeting this important malaria vector.

  1. Microscopic theory of the insulating electronic ground states of the actinide dioxides AnO2 (An = U, Np, Pu, Am, and Cm)

    NASA Astrophysics Data System (ADS)

    Suzuki, M.-T.; Magnani, N.; Oppeneer, P. M.

    2013-11-01

    The electronic states of the actinide dioxides AnO2 (with An = U, Np, Pu, Am, and Cm) are investigated employing first-principles calculations within the framework of the local density approximation +U (LDA+U) approach, implemented in a full-potential linearized augmented plane-wave scheme. A systematic analysis of the An-5f states is performed which provides intuitive connections between the electronic structures and the local crystalline fields of the f states in the AnO2 series. Particularly the mechanisms leading to the experimentally observed insulating ground states are investigated. These are found to be caused by the strong spin-orbit and Coulomb interactions of the 5f orbitals; however, as a result of the different configurations, this mechanism works in distinctly different ways for each of the AnO2 compounds. In agreement with experimental observations, the nonmagnetic states of plutonium and curium dioxide are computed to be insulating, whereas those of uranium, neptunium, and americium dioxides require additional symmetry breaking to reproduce the insulator ground states, a condition which is met with magnetic phase transitions. We show that the occupancy of the An-f orbitals is closely connected to each of the appearing insulating mechanisms. We furthermore investigate the detailed constitution of the noncollinear multipolar moments for transverse 3q magnetic ordered states in UO2 and longitudinal 3q high-rank multipolar ordered states in NpO2 and AmO2.

  2. Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

    PubMed Central

    Xiao, Qinghuan; Yu, Kuai; Perez-Cornejo, Patricia; Cui, Yuanyuan; Arreola, Jorge; Hartzell, H. Criss

    2011-01-01

    Ca2+-activated Cl− channels (CaCCs) are exceptionally well adapted to subserve diverse physiological roles, from epithelial fluid transport to sensory transduction, because their gating is cooperatively controlled by the interplay between ionotropic and metabotropic signals. A molecular understanding of the dual regulation of CaCCs by voltage and Ca2+ has recently become possible with the discovery that Ano1 (TMEM16a) is an essential subunit of CaCCs. Ano1 can be gated by Ca2+ or by voltage in the absence of Ca2+, but Ca2+- and voltage-dependent gating are very closely coupled. Here we identify a region in the first intracellular loop that is crucial for both Ca2+ and voltage sensing. Deleting 448EAVK in the first intracellular loop dramatically decreases apparent Ca2+ affinity. In contrast, mutating the adjacent amino acids 444EEEE abolishes intrinsic voltage dependence without altering the apparent Ca2+affinity. Voltage-dependent gating of Ano1 measured in the presence of intracellular Ca2+ was facilitated by anions with high permeability or by an increase in [Cl−]e. Our data show that the transition between closed and open states is governed by Ca2+ in a voltage-dependent manner and suggest that anions allosterically modulate Ca2+-binding affinity. This mechanism provides a unified explanation of CaCC channel gating by voltage and ligand that has long been enigmatic. PMID:21555582

  3. Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms.

    PubMed

    Scudieri, Paolo; Caci, Emanuela; Venturini, Arianna; Sondo, Elvira; Pianigiani, Giulia; Marchetti, Carla; Ravazzolo, Roberto; Pagani, Franco; Galietta, Luis J V

    2015-09-01

    TMEM16F is a membrane protein with possible dual function as an ion channel and a phospholipid scramblase. The properties of ion channels associated with TMEM16F and the link between ion channel and scramblase activity are a matter of debate. We studied the properties of four isoforms of TMEM16F generated by alternative splicing. Upregulation of three TMEM16F isoforms or silencing of endogenous TMEM16F increased and decreased, respectively, both scramblase and channel activities. Introduction of an activating mutation in TMEM16F sequence caused a marked increase in phosphatidylserine scrambling and in ion transport indicating direct involvement of the protein in both functions. TMEM16F, also known as ANO6, is a membrane protein that has been associated with phospholipid scramblase and ion channel activity. However, the characteristics of TMEM16F-dependent channels, particularly the ion selectivity, are a matter of debate. Furthermore, the direct involvement of TMEM16F in phospholipid scrambling has been questioned. We studied the properties of different TMEM16F variants generated by alternative splicing. Using whole-cell patch-clamp recordings, we found that V1, V2 and V5 variants generated membrane currents activated by very high (micromolar) intracellular Ca(2+) concentrations and positive membrane potentials. These variants showed different degrees of Ca(2+) sensitivity and kinetics of activation but similar ion permeability, characterized by a slight selectivity for Cl(-) over Na(+) . A fourth variant (V3) showing a unique carboxy-terminus was devoid of activity, in agreement with its intracellular localization. We also measured scramblase activity using the binding of annexin V to detect phosphatidylserine on the cell surface. V1, V2 and V5 variants were associated with calcium-dependent phosphatidylserine externalization. Interestingly, introduction of an activating mutation, D409G, produced a marked increase in the apparent Ca(2+) sensitivity of TMEM16F

  4. Potassium and ANO1/TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis

    PubMed Central

    Iqbal, Javed; Tonta, Mary A; Mitsui, Retsu; Li, Qun; Kett, Michelle; Li, Jinhua; Parkington, Helena C; Hashitani, Hikaru; Lang, Richard J

    2012-01-01

    BACKGROUND AND PURPOSE Although atypical smooth muscle cells (SMCs) in the proximal renal pelvis are thought to generate the pacemaker signals that drive pyeloureteric peristalsis, their location and electrical properties remain obscure. EXPERIMENTAL APPROACH Standard patch clamp, intracellular microelectrode and immunohistochemistry techniques were used. To unequivocally identify SMCs, transgenic mice with enhanced yellow fluorescent protein (eYFP) expressed in cells containing α-smooth muscle actin (α-SMA) were sometimes used. KEY RESULTS Atypical SMCs were distinguished from typical SMCs by the absence of both a transient 4-aminopyridine-sensitive K+ current (IKA) and spontaneous transient outward currents (STOCs) upon the opening of large-conductance Ca2+-activated K+ (BK) channels. Many typical SMCs displayed a slowly activating, slowly decaying Cl- current blocked by niflumic acid (NFA). Immunostaining for KV4.3 and ANO1/ TMEM16A Cl- channel subunits co-localized with α-SMA immunoreactive product predominately in the distal renal pelvis. Atypical SMCs fired spontaneous inward currents that were either selective for Cl- and blocked by NFA, or cation-selective and blocked by La3+. α-SMA- interstitial cells (ICs) were distinguished by the presence of a Xe991-sensitive KV7 current, BK channel STOCs and Cl- selective, NFA-sensitive spontaneous transient inward currents (STICs). Intense ANO1/ TMEM16A and KV7.5 immunostaining was present in Kit-α-SMA- ICs in the suburothelial and adventitial regions of the renal pelvis. CONCLUSIONS AND IMPLICATIONS We conclude that KV4.3+α-SMA+ SMCs are typical SMCs that facilitate muscle wall contraction, that ANO1/ TMEM16A and KV7.5 immunoreactivity may be selective markers of Kit- ICs and that atypical SMCs which discharge spontaneous inward currents are the pelviureteric pacemakers. PMID:22014103

  5. Whole exome sequencing links dental tumor to an autosomal-dominant mutation in ANO5 gene associated with gnathodiaphyseal dysplasia and muscle dystrophies

    PubMed Central

    Andreeva, T. V.; Tyazhelova, T. V.; Rykalina, V. N.; Gusev, F. E.; Goltsov, A. Yu.; Zolotareva, O. I.; Aliseichik, M. P.; Borodina, T. A.; Grigorenko, A. P.; Reshetov, D. A.; Ginter, E. K.; Amelina, S. S.; Zinchenko, R. A.; Rogaev, E. I.

    2016-01-01

    Tumors of the jaws may represent different human disorders and frequently associate with pathologic bone fractures. In this report, we analyzed two affected siblings from a family of Russian origin, with a history of dental tumors of the jaws, in correspondence to original clinical diagnosis of cementoma consistent with gigantiform cementoma (GC, OMIM: 137575). Whole exome sequencing revealed the heterozygous missense mutation c.1067G > A (p.Cys356Tyr) in ANO5 gene in these patients. To date, autosomal-dominant mutations have been described in the ANO5 gene for gnathodiaphyseal dysplasia (GDD, OMIM: 166260), and multiple recessive mutations have been described in the gene for muscle dystrophies (OMIM: 613319, 611307); the same amino acid (Cys) at the position 356 is mutated in GDD. These genetic data and similar clinical phenotypes demonstrate that the GC and GDD likely represent the same type of bone pathology. Our data illustrate the significance of mutations in single amino-acid position for particular bone tissue pathology. Modifying role of genetic variations in another gene on the severity of the monogenic trait pathology is also suggested. Finally, we propose the model explaining the tissue-specific manifestation of clinically distant bone and muscle diseases linked to mutations in one gene. PMID:27216912

  6. The Anopheles arabiensis genetic sexing strain ANO IPCL1 and its application potential for the sterile insect technique in integrated vector management programmes.

    PubMed

    Yamada, Hanano; Vreysen, Marc J B; Bourtzis, Kostas; Tschirk, Wolfgang; Chadee, Dave D; Gilles, Jeremie R L

    2015-02-01

    The Anopheles arabiensis genetic sexing strain ANO IPCL1 was developed based on a dieldrin resistant mutation. The strain has been shown to be practical and reliable in terms of female elimination by dieldrin treatments at larval stages, but has provided some difficulties when treatments were applied at the egg stage. The high natural sterility of this strain has advantages and disadvantages in both mass rearing and the sterilization process. In addition, its recombination rate, although relatively low, poses a threat of strain deterioration if left unchecked in a mass-rearing setting. The males of the ANO IPCL1 have been shown to be equally competitive as lab-reared males of the wild-type Dongola strain, but competitiveness decreased by half when irradiated with 75 Gy—a dose conferring >98% sterility. More controversial issues surround the use of dieldrin—a highly persistent organochlorine that is known to bioaccumulate in the food chain. The prospective use of large volumes of dieldrin in a mass-rearing facility and the retention of its residues by the male mosquitoes makes the use of the strain in the context of the sterile insect technique against this vector highly questionable, and therefore its implementation at a large scale cannot be recommended.

  7. Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia.

    PubMed

    Vermeer, Sascha; Hoischen, Alexander; Meijer, Rowdy P P; Gilissen, Christian; Neveling, Kornelia; Wieskamp, Nienke; de Brouwer, Arjan; Koenig, Michel; Anheim, Mathieu; Assoum, Mirna; Drouot, Nathalie; Todorovic, Slobodanka; Milic-Rasic, Vedrana; Lochmüller, Hanns; Stevanin, Giovanni; Goizet, Cyril; David, Albert; Durr, Alexandra; Brice, Alexis; Kremer, Berry; van de Warrenburg, Bart P C; Schijvenaars, Mascha M V A P; Heister, Angelien; Kwint, Michael; Arts, Peer; van der Wijst, Jenny; Veltman, Joris; Kamsteeg, Erik-Jan; Scheffer, Hans; Knoers, Nine

    2010-12-10

    Autosomal-recessive cerebellar ataxias comprise a clinically and genetically heterogeneous group of neurodegenerative disorders. In contrast to their dominant counterparts, unraveling the molecular background of these ataxias has proven to be more complicated and the currently known mutations provide incomplete coverage for genotyping of patients. By combining SNP array-based linkage analysis and targeted resequencing of relevant sequences in the linkage interval with the use of next-generation sequencing technology, we identified a mutation in a gene and have shown its association with autosomal-recessive cerebellar ataxia. In a Dutch consanguineous family with three affected siblings a homozygous 12.5 Mb region on chromosome 3 was targeted by array-based sequence capture. Prioritization of all detected sequence variants led to four candidate genes, one of which contained a variant with a high base pair conservation score (phyloP score: 5.26). This variant was a leucine-to-arginine substitution in the DUF 590 domain of a 16K transmembrane protein, a putative calcium-activated chloride channel encoded by anoctamin 10 (ANO10). The analysis of ANO10 by Sanger sequencing revealed three additional mutations: a homozygous mutation (c.1150_1151del [p.Leu384fs]) in a Serbian family and a compound-heterozygous splice-site mutation (c.1476+1G>T) and a frameshift mutation (c.1604del [p.Leu535X]) in a French family. This illustrates the power of using initial homozygosity mapping with next-generation sequencing technology to identify genes involved in autosomal-recessive diseases. Moreover, identifying a putative calcium-dependent chloride channel involved in cerebellar ataxia adds another pathway to the list of pathophysiological mechanisms that may cause cerebellar ataxia.

  8. Comparison of EPA's QMS to SEI's CMMI.

    PubMed

    Mills, P; Braun, L; Marohl, D

    2001-01-01

    EPA and other government organizations make decisions based on environmental measurements. How good are the data? How well are the data generators performing? What measurements apply to them? How can the data life cycle processes be improved so data generators can continually provide the best data? EPA's Quality Management System requirements go beyond evaluation of environmental data quality itself to examine systems associated with production, collection, processing (validation/verification), transfer, reduction, storage, and retrieval of data throughout a life cycle. This QMS specifies minimum quality requirements for particular environmental programs. But how can you measure and compare programs that go well beyond the minimum, towards optimal quality? This paper compares EPA's requirements for Quality Management Systems (R2) and Project Plans (R5) to the Software Engineering Institute Capability Maturity Model (CMMISM). The CMMISM model provides for growth (staged or continuous) and a comprehensive assessment that is not yet provided in EPA's R2 or R5. Properly implemented, the CMMISM model serves as a quality framework for integrating and aligning organizational processes and implementing a program of continual process improvements. It identifies process areas ("things to do"), and provides measures of performance ("how well things are done") against specific goals and practices. CMMISM uses a Systems Engineering Management approach, built on process models, that helps identify "how good" the system is. Goodness is defined as stages in a complete model for optimal operation. CMMISM provides two methods for evaluating the goodness of the project. The Staged model in CMMISM provides a Maturity Level that is a well-defined evolutionary plateau describing the manner in which a specified set of processes are performed. As the organization advances in maturity, these levels become more defined and processes are tailored for specific project needs. The other method is called the Continuous Model in CMMISM, and it allows you to achieve Capability Levels. These are used to describe how well each project is doing in relationship to the different process areas. There are six Capability Levels from 0-5 that apply to individual process areas. Organizations using the Capability Level approach can select individual process areas that are important to specific projects and work to improve the processes. Improving capability in individual process areas raises the organization's overall quality of products delivered. The Continuous Model, unlike the Staged Model, lets you pick higher maturity level process areas before completing all of the ones below. Environmental measurement programs need to focus on the quality of the systems where data are collected, processed, transferred, and so forth. DynCorp built on the quality foundation from our experience with R2 to successfully implement CMMISM practices in the development of Forms II Lite and other applications. DynCorp is now migrating to the CMMISM model that has evolved from the existing CMM model. The CMMISM model focuses on the full cycle of Requirements Management from identification, development, collection, refinement, analysis, and validation throughout a project life cycle. It also has a more refined focus on the identification, development, collection, analysis, and evaluation of meaningful measurements, so the results can be used to improve a process or product.

  9. SEI needs for space nuclear power

    NASA Technical Reports Server (NTRS)

    Brandhorst, H. W.; Cataldo, R. L.

    1991-01-01

    The use of nuclear electric propulsion (NEP) and nuclear thermal propulsion (NTP) for transportation to the moon and Mars is examined, and the use on Mars and moon bases of thermal conversion subsystems based on either a Brayton or a Stirling cycle is examined. It is shown that both cycles are attractive alternatives for those applications where continuous field operation is desired. Nuclear power systems have a clear advantage with regard to the moon and a lesser one with regard to Mars.

  10. Shizuko Sei, MD | Division of Cancer Prevention

    Cancer.gov

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  11. SeisCORK Engineering Design Study

    DTIC Science & Technology

    2006-05-01

    nano - and micro -earthquakes, a nano -earthquake is comparable to breaking a baseball bat) for three reasons: 1) After an event fluid may flow in the...biology) may provide precursors to the seismic activity. This is exciting. We want to see the small events ( nano - and micro -earthquakes, a nano ...casing scenarios and science goals, is an excellent concept. Although the primary science goal is micro - and nano -earthquake monitoring, if possible, we

  12. Bonding trends across the series of tricarbonato-actinyl anions [(AnO2)(CO3)3](4-) (An = U-Cm): the plutonium turn.

    PubMed

    Liu, Jian-Biao; Chen, Guo P; Huang, Wei; Clark, David L; Schwarz, W H Eugen; Li, Jun

    2017-02-21

    Actinyl-tricarbonato anions [(AnO2)(CO3)3](4-) (An = U-Cm) in various environments were investigated using theoretical approaches of quantum-mechanics, molecular-mechanics and cluster-models. Cations and solvent molecules in the 2(nd) coordination sphere affect the equatorial An←Oeq bonds more than the axial An[triple bond, length as m-dash]Oax bonds. Common actinide contraction is found for calculated and experimental axial bond lengths of 92U to 94Pu, though no longer for 94Pu to 96Cm. The tendency of U to Pu forming actinyl(vi) species dwindles away toward Cm, which already features the preferred An(III)/Ln(III) oxidation state of the later actinides and all lanthanides. The well known change from d-type to typical U-Pu-Cm type and then to f-type behavior is labeled as the plutonium turn, a phenomenon that is caused by f-orbital energy-decrease and f-orbital localization with increase of both nuclear charge and oxidation state, and a non-linear variation of effective f-electron population across the actinide series. Both orbital and configuration mixing and occupation of antibonding 5f type orbitals increase, weakening the AnOax bonds and reducing the highest possible oxidation states of the later actinides.

  13. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.

    PubMed

    Piechowicz, Katarzyna A; Truong, Eric C; Javed, Kashif M; Chaney, Rachelle R; Wu, Johnny Y; Phuan, Puay W; Verkman, Alan S; Anderson, Marc O

    2016-12-01

    Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca(2+) activated Cl(-) channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole T16Ainh-01 was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in T16Ainh-01. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. We found that very little structural variation of T16Ainh-01 was tolerated, with most compounds showing no activity at 10 μM. The most potent compound in the series, 9bo, which substitutes 4-methoxyphenyl in T16Ainh-01 with 2-thiophene, had IC50 ∼1 μM for inhibition of TMEM16A chloride conductance.

  14. Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1

    PubMed Central

    Piechowicz, Katarzyna A.; Truong, Eric C.; Javed, Kashif M.; Chaney, Rachelle R.; Wu, Johnny Y.; Phuan, Puay W.; Verkman, Alan S.; Anderson, Marc O.

    2016-01-01

    Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca2+ activated Cl− channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole T16Ainh-01 was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in T16Ainh-01. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. We found that very little structural variation of T16Ainh-01 was tolerated, with most compounds showing no activity at 10 µM. The most potent compound in the series, 9bo, which substitutes 4-methoxyphenyl in T16Ainh-01 with 2-thiophene, had IC50 ~1 µM for inhibition of TMEM16A chloride conductance. PMID:26796863

  15. OA03.11. A comparative study of guggulu chitrak kshar – sutra and snuhi apamarg kshar – sutra in the management of fistula in ano

    PubMed Central

    Gond, Pushpa; Kumar, Ashok; Rajeshwari, PN; Choudhary, PC; Kumar, Jitendra

    2013-01-01

    Purpose: Fistula in ano is a condition which has been recognized as difficult surgical diseases in all the ancient and modern medical sciences of the world. In Ayurvedic texts fistulainano is described as Bhagandar. This disease is recurrent in nature which makes it more difficult for treatment. So it produces inconvenience in routine life. KsharSutra has been proved as a big revolution in the treatment of fistulainano. It is the need to do further researches to get more efficient Kshar Sutra. Method: The present study was clinical, randomised, single blind trial. In the present research work Guggulu Chitraka KsharSutra has been taken for comparative study wth snuhi apamarga ksharsutra. Thirty patients cases of fistulainano were selected from OPD/IPD of Shalya Tantra department of National Institute of Ayurveda, Jaipur. Total patients were divided into two equal groups. The patients of group A were treated with Snuhi Apamarga KsharSutra and the patients of group B were treated with Guggulu Chitraka KsharSutra. Result: In the study the effect of Guggulu Chitraka KsharSutra was found better in pain, itching, pus discharge, tenderness and burning sensation and the rate of Unit Cutting Time was slightly higher as Snuhi Apamarga KsharSutra. Conclusion: Though U.C.T of Guggulu Chitrak Kshara Sutra is slightly higher than Snuhi Apamarga Kshar Sutra, but in assessment parameter Guggulu Chitrak Kshar Sutra has been shown significant result. With guggulu chitrak ksharsutra post ligation complications like hypertrophied scar etc are not seen and this is easily available and cost effective.

  16. Static electric dipole polarizabilities of An5+/6+ and AnO2+/2+ (An = U, Np, and Pu) ions

    NASA Astrophysics Data System (ADS)

    Parmar, Payal; Peterson, Kirk A.; Clark, Aurora E.

    2014-12-01

    The parallel components of static electric dipole polarizabilities have been calculated for the lowest lying spin-orbit states of the penta- and hexavalent oxidation states of the actinides (An) U, Np, and Pu, in both their atomic and molecular diyl ion forms (An5+/6+ and AnO2+/2+) using the numerical finite-field technique within a four-component relativistic framework. The four-component Dirac-Hartree-Fock method formed the reference for MP2 and CCSD(T) calculations, while multireference Fock space coupled-cluster (FSCC), intermediate Hamiltonian Fock space coupled-cluster (IH-FSCC) and Kramers restricted configuration interaction (KRCI) methods were used to incorporate additional electron correlation. It is observed that electron correlation has significant (˜5 a.u.3) impact upon the parallel component of the polarizabilities of the diyls. To the best of our knowledge, these quantities have not been previously reported and they can serve as reference values in the determination of various electronic and response properties (for example intermolecular forces, optical properties, etc.) relevant to the nuclear fuel cycle and material science applications. The highest quality numbers for the parallel components (αzz) of the polarizability for the lowest Ω levels corresponding to the ground electronic states are (in a.u.3) 44.15 and 41.17 for UO2+ and UO22+, respectively, 45.64 and 41.42 for NpO2+ and NpO22+, respectively, and 47.15 for the PuO2+ ion.

  17. Static electric dipole polarizabilities of An(5+/6+) and AnO2 (+/2+) (An = U, Np, and Pu) ions.

    PubMed

    Parmar, Payal; Peterson, Kirk A; Clark, Aurora E

    2014-12-21

    The parallel components of static electric dipole polarizabilities have been calculated for the lowest lying spin-orbit states of the penta- and hexavalent oxidation states of the actinides (An) U, Np, and Pu, in both their atomic and molecular diyl ion forms (An(5+/6+) and AnO2 (+/2+)) using the numerical finite-field technique within a four-component relativistic framework. The four-component Dirac-Hartree-Fock method formed the reference for MP2 and CCSD(T) calculations, while multireference Fock space coupled-cluster (FSCC), intermediate Hamiltonian Fock space coupled-cluster (IH-FSCC) and Kramers restricted configuration interaction (KRCI) methods were used to incorporate additional electron correlation. It is observed that electron correlation has significant (∼5 a.u.(3)) impact upon the parallel component of the polarizabilities of the diyls. To the best of our knowledge, these quantities have not been previously reported and they can serve as reference values in the determination of various electronic and response properties (for example intermolecular forces, optical properties, etc.) relevant to the nuclear fuel cycle and material science applications. The highest quality numbers for the parallel components (αzz) of the polarizability for the lowest Ω levels corresponding to the ground electronic states are (in a.u.(3)) 44.15 and 41.17 for UO2 (+) and UO2 (2+), respectively, 45.64 and 41.42 for NpO2 (+) and NpO2 (2+), respectively, and 47.15 for the PuO2 (+) ion.

  18. Real time monitoring of induced seismicity in the Insheim and Landau deep geothermal reservoirs, Upper Rhine Graben, using the new SeisComP3 cross-correlation detector

    NASA Astrophysics Data System (ADS)

    Vasterling, Margarete; Wegler, Ulrich; Bruestle, Andrea; Becker, Jan

    2016-04-01

    Real time information on the locations and magnitudes of induced earthquakes is essential for response plans based on the magnitude frequency distribution. We developed and tested a real time cross-correlation detector focusing on induced microseismicity in deep geothermal reservoirs. The incoming seismological data are cross-correlated in real time with a set of known master events. We use the envelopes of the seismograms rather than the seismograms themselves to account for small changes in the source locations or in the focal mechanisms. Two different detection conditions are implemented: After first passing a single trace correlation condition, secondly a network correlation is calculated taking the amplitude information of the seismic network into account. The magnitude is estimated by using the respective ratio of the maximum amplitudes of the master event and the detected event. The detector is implemented as a real time tool and put into practice as a SeisComp3 module, an established open source software for seismological real time data handling and analysis. We validated the reliability and robustness of the detector by an offline playback test using four month of data from monitoring the power plant in Insheim (Upper Rhine Graben, SW Germany). Subsequently, in October 2013 the detector was installed as real time monitoring system within the project "MAGS2 - Microseismic Activity of Geothermal Systems". Master events from the two neighboring geothermal power plants in Insheim and Landau and two nearby quarries are defined. After detection, manual phase determination and event location are performed at the local seismological survey of the Geological Survey and Mining Authority of Rhineland-Palatinate. Until November 2015 the detector identified 454 events out of which 95% were assigned correctly to the respective source. 5% were misdetections caused by local tectonic events. To evaluate the completeness of the automatically obtained catalogue, it is

  19. Study of the Local Horizon. (Spanish Title: Estudio del Horizonte Local.) Estudo do Horizonte Local

    NASA Astrophysics Data System (ADS)

    Ros, Rosa M.

    2009-12-01

    The study of the horizon is fundamental to easy the first observations of the students at any education center. A simple model, to be developed in each center, allows to easy the study and comprehension of the rudiments of astronomy. The constructed model is presented in turn as a simple equatorial clock, other models (horizontal and vertical) may be constructed starting from it. El estudio del horizonte es fundamental para poder facilitar las primeras observaciones de los alumnos en un centro educativo. Un simple modelo, que debe realizarse para cada centro, nos permite facilitar el estudio y la comprensión de los primeros rudimentos astronómicos. El modelo construido se presenta a su vez como un sencillo modelo de reloj ecuatorial y a partir de él se pueden construir otros modelos (horizontal y vertical). O estudo do horizonte é fundamental para facilitar as primeiras observações dos alunos num centro educativo. Um modelo simples, que deve ser feito para cada centro, permite facilitar o estudo e a compreensão dos primeiros rudimentos astronômicos. O modelo construído apresenta-se, por sua vez, como um modelo simples de relógio equatorial e a partir dele pode-se construir outros modelos (horizontal e vertical)

  20. Difficulties of First Years Elementary School Teachers with the Teaching of Astronomy. (Breton Title: Dificuldades de Professores dos Anos Iniciais do Ensino Fundamental em Relação ao Ensino da Astronomia. ) Dificultades de LOS Profesores de los Primeros Años de la Escuela Primaria en Relación a la Enseñanza de la Astronomía

    NASA Astrophysics Data System (ADS)

    Langhi, Rodolfo; Nardi, Roberto

    2005-12-01

    This paper reports Primary School teachers' discourses analysis about their difficulties related to the teaching of Astronomy. It reports partial data of a master's level research carried out in the last two years, named "An exploratory study for inserting Astronomy in primary school teachers' education" (LANGHI, 2004). The study took into consideration students' and teachers' common sense conceptions about astronomical phenomena, conceptual mistakes in textbooks, and Astronomy's suggestions given by the PCN (Parâmetros Curriculares Nacionais - The Brazilian National Curriculum Standards). The paper aims to characterize teachers' difficulties, in order to provide subsides to the implementation of an initial or continuing education program. This study is justified by the fact that courses plans like these only will be adapted to the teacher's (and students') reality, if there is a primary investigation about what the teachers really need to know about Astronomy. This fact was possible here by the enunciations interpretation of a teachers' sample using semi-structured interviews, according to discourse analysis procedures. The research outcomes show difficulties related to factors like: those of personal order, methodological, on teacher's formation, educational infrastructure and other related to information sources for educators. Este artigo, que relata as dificuldades de professores em relação ao ensino da Astronomia, faz parte de um estudo exploratório para a inserção da Astronomia na formação de professores dos anos iniciais do Ensino Fundamental. Esse estudo leva em consideração as concepções alternativas de alunos e professores sobre fenômenos astronômicos, os erros conceituais em livros didáticos e as sugestões de conteúdos de Astronomia constantes nos PCN (Parâmetros Curriculares Nacionais). Caracterizar as dificuldades dos professores é a questão central deste texto, apontando para o objetivo de contribuir com subsídios para um futuro

  1. Effect of spin-orbit coupling on the actinide dioxides AnO2 (An=Th, Pa, U, Np, Pu, and Am): A screened hybrid density functional study

    NASA Astrophysics Data System (ADS)

    Wen, Xiao-Dong; Martin, Richard L.; Roy, Lindsay E.; Scuseria, Gustavo E.; Rudin, Sven P.; Batista, Enrique R.; McCleskey, Thomas M.; Scott, Brian L.; Bauer, Eve; Joyce, John J.; Durakiewicz, Tomasz

    2012-10-01

    We present a systematic comparison of the lattice structures, electronic density of states, and band gaps of actinide dioxides, AnO2 (An=Th, Pa, U, Np, Pu, and Am) predicted by the Heyd-Scuseria-Ernzerhof screened hybrid density functional (HSE) with the self-consistent inclusion of spin-orbit coupling (SOC). The computed HSE lattice constants and band gaps of AnO2 are in consistently good agreement with the available experimental data across the series, and differ little from earlier HSE results without SOC. ThO2 is a simple band insulator (f 0), while PaO2, UO2, and NpO2 are predicted to be Mott insulators. The remainders (PuO2 and AmO2) show considerable O2p/An5f mixing and are classified as charge-transfer insulators. We also compare our results for UO2, NpO2, and PuO2 with the PBE+U, self interaction correction (SIC), and dynamic mean-field theory (DMFT) many-body approximations.

  2. A Reappraising of Cosmography: the Interface Between Astronomical and Geographic Studies. (Breton Title: Releitura do Conceito de Cosmografia: a Interface Entre os Estudos Astronômicos e Geográficos.) Una Relectura del Concepto de Cosmografía: la Interfase Entre los Estudios Astronómicos y Geográficos

    NASA Astrophysics Data System (ADS)

    Azevedo Sobreira, Paulo Henrique

    2012-12-01

    The concept of "Cosmography" is in disuse since the 80s of the last century, but the astronomical themes previously discussed in the school subjects of Geography and Cosmography remain in current textbooks. The use of term "Cosmography" was rescued in this research, and the study of its re-signification prompted the appearance of the term Geographic Cosmography. The Geographic Cosmography is a field of studies of the Geography, whose set of knowledge and skills is predominantly scholar. It studies the interface between terrestrial and celestial knowledge, and assigns a geographic significance to them. It examines human and natural relationships with Sidereal Space and its consequences for society and nature. O conceito de "Cosmografia" está em desuso desde os anos 80 do século XX, mas os temas astronômicos anteriormente abordados nas disciplinas escolares de Cosmografia e de Geografia permanecem nos atuais livros didáticos. O uso do termo "Cosmografia" foi resgatado nesta pesquisa e o estudo de sua ressignificação proporcionou o surgimento do termo Cosmografia Geográfica. A Cosmografia Geográfica é um campo de estudos da Geografia, cujo conjunto de conhecimentos e habilidades é predominantemente escolar. Estuda a interface entre os conhecimentos terrestres e os celestes e lhes atribui significância geográfica. Analisa as relações humanas e naturais com o Espaço Sideral e suas consequências para a sociedade e a natureza.

    Aunque el concepto de "Cosmografía" no se usa desde la década de los '80 del siglo pasado, los temas astronómicos que se enseñaban anteriormente en las asignaturas escolares de Cosmografía y de Geografía permanecen en los actuales libros didácticos. El uso del término "Cosmografía" fue rescatado en esta investigación y el estudio de su resignificación proporcionó el surgimiento del término Cosmografía Geográfica. La Cosmografía Geográfica es un campo de estudio de la Geografía, donde

  3. Results of SEI Line-Funded Exploratory New Starts Projects

    DTIC Science & Technology

    2012-08-01

    for the suffix tree data structure to include lightweight set encodings based on a technique called bit- arrays but designed for sparse arrays ...Homann 2009] Homann, R., Fleer, D., Giegerich, R., & Rehmsmeier, M. “mkESA: Enhanced Suffix Array Con- struction Tool.” Bioinformatics 25, 8 (2009...raw data for efficient resolution of string matching. We instrument suffix tree data structures and algorithms found in bio-informatics stud- ies

  4. Results of SEI Independent Research and Development Projects

    DTIC Science & Technology

    2011-02-01

    probabilities, and the states them- selves have been assigned code bytes that are to be generated when the state is visited . For exam- ple, in the following...Thus, in order to apply their framework to our problem, we had to visit each of these many choices to determine the best option for our problem domain...University, 2009. www.cert.org/research/2008research- report.pdf [Pleszkoch 2009] Pleszkoch, Mark & Cohen, Cory. Detection of the Allaple Polymorphic Packer

  5. Dynamics of stochastic SEIS epidemic model with varying population size

    NASA Astrophysics Data System (ADS)

    Liu, Jiamin; Wei, Fengying

    2016-12-01

    We introduce the stochasticity into a deterministic model which has state variables susceptible-exposed-infected with varying population size in this paper. The infected individuals could return into susceptible compartment after recovering. We show that the stochastic model possesses a unique global solution under building up a suitable Lyapunov function and using generalized Itô's formula. The densities of the exposed and infected tend to extinction when some conditions are being valid. Moreover, the conditions of persistence to a global solution are derived when the parameters are subject to some simple criteria. The stochastic model admits a stationary distribution around the endemic equilibrium, which means that the disease will prevail. To check the validity of the main results, numerical simulations are demonstrated as end of this contribution.

  6. Advancing Cyber Intelligence Practices Through the SEI’s Consortium

    DTIC Science & Technology

    2015-01-27

    and why Training Type and quality Intent Motive Intrinsic Personal rewards to act on the threat-bragging rights, knowledge, justify skills...satisfy boredom, patriotism, or hacktivist a llegiance Extrinsic External rewards to act on the threat- fame, money--or to avoid punishment...localjnational politics Motive The reasons for why such individuals are susceptible to the cyber threat-ignorance, financial trouble

  7. Camus: A Collection of Critical Essays. Twentieth Century Views Seies.

    ERIC Educational Resources Information Center

    Bree, Germaine, Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Germaine Bree, Nicola Chairmonte, Serge Doubrovsky, Justin O'Brien, Wilfrid Sheed, Roger Quilliot, Thomas L. Hanna, Bernard C. Murchland, Henri Peyre, S. Beynon John, Rachel Bespaloff, Jean-Paul Sartre, Robert Champigny,…

  8. SEI rover solar-electrochemical power system options

    NASA Technical Reports Server (NTRS)

    Withrow, Colleen A.; Kohout, Lisa L.; Bents, David J.; Colozza, Anthony J.

    1991-01-01

    A trade study of power system technology for proposed lunar vehicles and servicers is presented. A variety of solar-based power systems were selected and analyzed for each. The analysis determined the power system mass, volume, and deployed area. A comparison was made between periodic refueling/recharging systems and onboard power systems to determine the most practical system. The trade study concluded that the power system significantly impacts the physical characteristics of the vehicle. The refueling/recharging systems were lighter and more compact, but dependent on availability of established lunar base infrastructure. Onboard power systems pay a mass penalty for being fully developed systems.

  9. Near-term thermoelectric nuclear power options for SEI missions

    NASA Technical Reports Server (NTRS)

    Peterson, Jerry R.

    1992-01-01

    Three different types of thermoelectric nuclear space power systems are discussed. First, the general purpose heat source Radioisotope Thermoelectric Generator (RTG), which was qualified and flown on Galileo/Ulysses and is in development for Cassini, is discussed. Second, the modular RTG, which is undergoing life verification, is discussed. Finally, the SP-100 is discussed. The information is presented in viewgraph form.

  10. Results of SEI Independent Research and Development Projects

    DTIC Science & Technology

    2008-07-01

    traditional Liu and Layland task model to include the demand of memory band- width where caches play a big role [Liu 1973]. In our task model, a task...sacrifices opportunities to fuse track data to improve the quality of the common operating picture. Our concept is to auction additional quanta of...summarized below. Question 1: What is the scarce resource? We will auction additional quanta of bandwidth beyond the baseline R2 protocol, so that

  11. Laser photovoltaic power system synergy for SEI applications

    NASA Technical Reports Server (NTRS)

    Landis, Geoffrey A.; Hickman, J. M.

    1991-01-01

    Solar arrays can provide reliable space power, but do not operate when there is no solar energy. Photovoltaic arrays can also convert laser energy with high efficiency. One proposal to reduce the required mass of energy storage required is to illuminate the photovoltaic arrays by a ground laser system. It is proposed to locate large lasers on cloud-free sites at one or more ground locations, and use large lenses or mirrors with adaptive optical correction to reduce the beam spread due to diffraction or atmospheric turbulence. During the eclipse periods or lunar night, the lasers illuminate the solar arrays to a level sufficient to provide operating power.

  12. SEI nuclear technology findings by the Stafford Synthesis Group

    SciTech Connect

    Buden, D. )

    1991-01-01

    Nuclear propulsion is key to reducing travel time to Mars, greatly reducing the mass in low Earth orbit, and enhancing schedule flexibility by increasing the Earth orbit departure launch window. Nuclear thermal rockets have twice to three times the performance of the best chemical rockets. This directly translates into reduced trip times and lower mass in low Earth orbit. Trip times of < 400 days in space are possible, a limitation if restricted to chemical propulsion. Psychological, physiological and radiological problems are significant issues for long mission times. The psychology of being cooped up so long in a minimum-sized capsule is cause for concern - much longer than considered healthy for nuclear submarine crews. The effects of long-term weightlessness are being debated. Short trip times eliminate the need for artificial gravity. The largest uncertainty is the effect of galactic radiation that will expose the crew to high levels of radiation for as much as 60 rem/yr.

  13. SEI SPRUCE Project: Curating Recommended Practices for Software Producibility

    DTIC Science & Technology

    2015-01-01

    recommended practices per month until we had published web pages on five software topics. Having a small collection of high-quality content for visitors to...recommended practices for five software topics, we began to develop approaches for a promotion campaign to announce the site, draw more traffic to it...Managing Intellectual Property in the Acquisition of Software -Intensive Systems The web page for Managing Intellectual Property in

  14. Results of SEI Independent Research and Development Projects

    DTIC Science & Technology

    2008-12-01

    Modern avionics architectures are multi- threaded to increase utilization of individual processors through techniques, such as rate - monotonic analysis...tool development. We also established industry collaborations with VistaPrint, Inc. 3.5 Evaluation Criteria The a priori success criteria for judging...sometimes called a social choice function: i ivF max Eq 4-1 where vi is the value v of some decision outcome for agent i. Now, each participant in the

  15. Results of SEI Independent Research and Development Projects

    DTIC Science & Technology

    2009-12-01

    goals. If we ask, for example, ―Why do you want this system to have a really fast response time?‖ we might hear that this will differentiate the product ...quality and reputation of products Figure 3-2: Ten Categories of Business Goals In addition to papers enumerating and describing business goals, we also...individual who has these goals has them for him/herself or his/her family. System These can be goals for a system being developed or acquired. Portfolio

  16. Summary of SEI (Software Engineering Institute) Technical Operations: 1987

    DTIC Science & Technology

    1988-01-01

    University (Texas Instruments) • Florida A & M University • George Mason University • Johns Hopkins University (Westinghouse Electric Corporation...assignments in 1987, two from the Navy, and one each from the Air Force and the Army. Craig Meyers and Roger Smeaton , both Navy affiliates, worked on...the Ada Embedded Systems Testbed Project. Meyers was from the Naval Surface Weapons Center in Dahlgren, Virginia; and Smeaton was from the Naval

  17. Results of SEI Independent Research and Development Projects

    DTIC Science & Technology

    2007-07-01

    Littlewood et al. [ Littlewood 1993] measure the operational security of a system by quantitatively estimating the intuitive notion of “the system’s ability to...2003. [ Littlewood 1993] Littlewood , B.; Brocklehurst, S.; Fenton, N.; Mellor, P.; Page, S.; Wright, D.; Dobson, J.; McDermid, J.; & Gollman, D

  18. The mechanism of the reduction of [AnO2]2+ (An = U, Np, Pu) in aqueous solution, and by Fe(II) containing proteins and mineral surfaces, probed by DFT calculations.

    PubMed

    Sundararajan, Mahesh; Assary, Rajeev S; Hillier, Ian H; Vaughan, David J

    2011-11-14

    The fate of actinyl species in the environment is closely linked to oxidation state, since the reduction of An(VI) to An(IV) greatly decreases their mobility due to the precipitation of the relatively insoluble An(IV) species. Here we study the mechanism of the reduction of [AnO(2)](2+) (An = U, Np, Pu) both in aqueous solution and by Fe(II) containing proteins and mineral surfaces, using density functional theory calculations. We find a disproportionation mechanism involving a An(V)-An(V) cation-cation complex, and we have investigated how these complexes are formed in the different environments. We find that the behaviour of U and Pu complexes are similar, but the reduction of Np(V) to Np(IV) would seems to be more difficult, in line with the experimental finding that Np(V) is generally more stable than U(V) or Pu(V). Although the models we have used are somewhat idealised, our calculations suggest that there are strong similarities between the biotic and abiotic reduction pathways.

  19. Estudo espectral em raios-X duros de fontes do tipo Z com o HEXTE/RXTE

    NASA Astrophysics Data System (ADS)

    D'Amico, F.; Heindl, W. A.; Rothschild, R. E.

    2003-08-01

    Apresentam-se os resultados de um estudo espectral em raios-X de fontes do tipo Z. As fontes do tipo Z são binárias de raios-X de baixa massa (BXBM) com campo magnético intermediário (B~109G). Esta classe de fontes é composta por apenas 6 fontes Galácticas (a saber: ScoX-1, 9, 7, CygX-2, 5 e 0). A nossa análise se concentra na faixa de raios-X duros (E ~ 20keV), até cerca de 200keV, faixa ótima de operação do telescópio "High Energy X-ray Timing Experiment" (HEXTE), um dos três telescópios de raios-X à bordo do Rossi X-ray Timing Explorer (RXTE). Nossa motivação para tal estudo, uma busca de caudas em raios-X duros em fontes do tipo Z, foi o pouco conhecimento sobre a emissão nesta faixa de energia das referidas fontes quando comparadas, por exemplo, as fontes do tipo atoll (também BXBM). Apresentam-se a análise/redução de dados e explicita-se a maneira como o HEXTE mede o ru1do de fundo. Especial atenção é direcionada a este item devido a localização das fontes do tipo Z e também ao problema de contaminação por fontes próximas. Com exceção de ScoX-1, nenhuma cauda em raios-X duros foi encontrada para as outras fontes, a despeito de resultados de detecção dessas caudas em algumas fontes pelo satélite BeppoSAX. As interpretações deste resultado serão apresentadas. Do ponto de vista deste estudo, nós deduzimos que a produção de caudas de raios-X duros em fontes do tipo Z é um processo disparado quando, pelo menos, uma condição é satisfeita: o brilho da componente térmica do espectro precisa estar acima de um certo valor limiar de ~4´1036ergs-1.

  20. Accounting for the differences in the structures and relative energies of the highly homoatomic np pi-np pi (n > or = 3)-bonded S2I4 2+, the Se-I pi-bonded Se2I4 2+, and their higher-energy isomers by AIM, MO, NBO, and VB methodologies.

    PubMed

    Brownridge, Scott; Crawford, Margaret-Jane; Du, Hongbin; Harcourt, Richard D; Knapp, Carsten; Laitinen, Risto S; Passmore, Jack; Rautiainen, J Mikko; Suontamo, Reijo J; Valkonen, Jussi

    2007-02-05

    The bonding in the highly homoatomic np pi-np pi (n > or = 3)-bonded S2I42+ (three sigma + two pi bonds), the Se-I pi-bonded Se2I42+ (four sigma + one pi bonds), and their higher-energy isomers have been studied using modern DFT and ab initio calculations and theoretical analysis methods: atoms in molecules (AIM), molecular orbital (MO), natural bond orbital (NBO), and valence bond (VB) analyses, giving their relative energies, theoretical bond orders, and atomic charges. The aim of this work was to seek theory-based answers to four main questions: (1) Are the previously proposed simple pi*-pi* bonding models valid for S2I42+ and Se2I42+? (2) What accounts for the difference in the structures of S2I42+ and Se2I42+? (3) Why are the classically bonded isolobal P2I4 and As2I4 structures not adopted? (4) Is the high experimentally observed S-S bond order supported by theoretical bond orders, and how does it relate to high bond orders between other heavier main group elements? The AIM analysis confirmed the high bond orders and established that the weak bonds observed in S2I42+ and Se2I42+ are real and the bonding in these cations is covalent in nature. The full MO analysis confirmed that S2I42+ contains three sigma and two pi bonds, that the positive charge is essentially equally distributed over all atoms, that the bonding between S2 and two I2+ units in S2I42+ is best described by two mutually perpendicular 4c2e pi*-pi* bonds, and that in Se2I42+, two SeI2+ moieties are joined by a 6c2e pi*-pi* bond, both in agreement with previously suggested models. The VB treatment provided a complementary approach to MO analysis and provided insight how the formation of the weak bonds affects the other bonds. The NBO analysis and the calculated AIM charges showed that the minimization of the electrostatic repulsion between EI2+ units (E = S, Se) and the delocalization of the positive charge are the main factors that explain why the nonclassical structures are favored for S2I42

  1. Learning about the Sky from the Environment: An Experience Working Along One Year with Students of Elementary Education. (Spanish Title: Aprendiendo sobre EL Cielo Desde el Entorno: Una Experiencia Trabajando Durante un Año Junto a Estudiantes del Primario.) Aprendendo sobre o Céu a Partir do Entorno: Uma Experiência de Trabalho ao Longo de um Ano com Alunos de Ensino Fundamental

    NASA Astrophysics Data System (ADS)

    Longhini, Marcos Daniel; Gomide, Hanny Angeles

    2014-12-01

    percepción limitada que los estudiantes tienen de su alrededor la cual, sin embargo, se expandió debido a las actividades llevadas a cabo, sobre todo en relación con la Luna. Trabajar con medidas sistemáticas revela el manejo cuidadoso de los datos para que sean comprensibles para los estudiantes, así como el trabajo con las sombras para que comprendan primero como se forman estas para después trabajarlas en Astronomía. Por último, llegamos a la conclusión de que el proceso desarrollado consistió en una etapa inicial de una obra que debe ser profundizado en los años posteriores de la formación de estos estudiantes. Projeto de pesquisa desenvolvido com 95 alunos do 6º ano do Ensino Fundamental de uma escola pública estadual de Uberlândia, Minas Gerais. Foi um trabalho contínuo, de fevereiro a dezembro de 2013, o qual levou os alunos a participarem de atividades de observação do entorno, dentre ele, o céu, analisando as mudanças ocorridas. Focamos no estudo das variações de temperaturas, chuvas, duração do dia, variações do tamanho das sombras e mudanças nos aspectos da Lua. Nosso foco de análise centrou-se em discutir os conhecimentos que os referidos alunos tinham acerca dos temas indicados no início e ao término da implementação da proposta. Os resultados mostraram a percepção limitada que os estudantes possuem de seu entorno, todavia, ampliada em função das atividades desenvolvidas, principalmente no que se refere à Lua. O trabalho com medidas sistemáticas revela o cuidado no tratamento dos dados para que eles se tornem compreensíveis aos alunos, assim como o trabalho com as sombras sinaliza para que os alunos primeiramente compreendam como as sombras são formadas para depois trabalhar isso em Astronomia. Por fim, concluímos que o processo vivido constituiu-se em uma etapa inicial de um trabalho que deve ser estimulado para os anos subsequentes da formação desses alunos.

  2. Um estudo espectrofotométrico da variável cataclísmica V3885 Sgr

    NASA Astrophysics Data System (ADS)

    Ribeiro, F. M. A.; Diaz, M. P.

    2003-08-01

    Variáveis Cataclísmicas são sistemas binários cerrados compostos de uma anã vermelha que transfere matéria para uma anã branca, em sistemas não magnéticos ocorre a formação de um disco de acresção em torno da anã branca. V3885 Sgr é uma variável cataclísmica classificada como sendo do tipo nova-like. É apresentado um estudo espectrofotométrico de V3885 Sgr de alta resolução temporal feito na região do visível. A região observada é centrada em Ha e abrange também a linha de HeI 6678. O primeiro resultado obtido neste estudo é a determinação do período orbital a partir de medidas da velocidade radial da linha de Ha como sendo 0,20716071(22) dias, resolvendo inconsistências quanto a esse valor na literatura e definindo uma efeméride a longo prazo para o sistema. Com este período e as medidas de velocidade radial do perfil de linha de Ha foi construído um diagrama de massas, através do qual restringimos as massas das componentes estelares do sistema e limitamos a inclinação orbital do sistema. Foram construídos diagramas de Greenstein para as linhas de Ha e HeI, onde os espectros médios em cada intervalo de fase são representados lado a lado em escala de cinza, indicando a existência de uma emissão intensa proveniente da parte posterior do disco. A partir da tomografia Doppler obtivemos perfis de emissividade radial para o disco tanto para a linha de Ha como para HeI. Os resultados obtidos são comparados com os de outros sistemas estudados com a mesma técnica. Serão apresentados também resultados da tomografia de flickering para o sistema.

  3. [Educational status and patterns of weight gain in adulthood in Brazil: Estudo Pró-Saúde].

    PubMed

    Fonseca, Maria de Jesus Mendes da; França, Rosana de Figueiredo; Faerstein, Eduardo; Werneck, Guilherme Loureiro; Chor, Dóra

    2012-11-01

    The aim of the present study was to investigate the association between participant and parental educational status (considered as an indicator of socioeconomic status) and participant pattern of weight gain in adulthood. We analyzed data from 2 582 baseline participants (1999) of Estudo Pró-Saúde (Pro-Health Study), a longitudinal investigation of civil servants from a public university in Rio de Janeiro, Brazil. Self-administered questionnaires were used to identify patterns of weight gain in adulthood. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated for the association between parental and participant educational status and steady weight gain or weight cycling, with stable weight as a reference, using multinomial logistic regression models. For males, lower paternal educational level entailed a chance about 55% lower of weight cycling as compared to stable weight (OR = 0.45; IC95% = 0.26-0.78), whereas lower maternal schooling was related to increased risk of weight cycling, although without reaching statistical significance (OR = 1.68; IC95% = 0.94-3.00). The association between participant educational status and weight history was not statistically significant among men. In women, lower educational status entailed a chance 94% higher of self-reported weight cycling (OR = 1.94; 95% CI = 1.17-3.23), and there was no association between parental educational level and history of weight gain. In this study, changes in weight throughout life, both steady and cyclic, were associated with parental and participant educational status, with major differences between genders.

  4. [Peritoneal Dialysis in the First Two Years of Life: Experience of a Nephrology and Renal Transplantation Pediatric Unit].

    PubMed

    Deuchande, Sofia; Mano, Tânia; Novais, Cristina; Machado, Rute; Stone, Rosário; Almeida, Margarida

    2016-09-01

    Introdução: A diálise peritoneal é o método dialítico de eleição perante doença renal crónica terminal em idade pediátrica. O objetivo deste estudo foi caracterizar a sobrevivência a longo prazo de uma população de crianças, que iniciou diálise peritoneal nos dois primeiros anos de vida. Material e Métodos: Estudo descritivo e retrospetivo, realizado numa unidade de nefrologia e transplantação renal pediátrica portuguesa, no período de janeiro de 1991 a agosto de 2014. Avaliou-se etiologia da doença renal crónica terminal, mortalidade, comorbilidades e complicações da diálise peritoneal e da doença renal crónica terminal, crescimento e desenvolvimento psicomotor.Resultados: Vinte crianças iniciaram diálise peritoneal antes dos dois anos. Ocorreram seis óbitos; não houve mortalidade em crianças com doença renal primária nos últimos 10 anos. Caracterizaram-se os 14 sobreviventes, 13 do sexo masculino. As anomalias congénitas do rim e do trato urinário constituíram a principal causa de doença renal crónica terminal (45%).O início de diálise peritoneal ocorreu em média aos 6,1 meses, em seis casos antes dos 30 dias de vida. A peritonite foi o motivo mais frequente de internamento. Dez crianças foram transplantadas, com idade média de 5,3 anos. Em relação ao crescimento, as quatro crianças que se mantêm em diálise peritoneal têm baixa estatura, mas nove dos transplantados têm uma estatura final dentro do esperado para a sua estatura-alvo familiar. Nove (64%) tiveram alterações no desenvolvimento psicomotor. Discussão: A diálise peritoneal é uma técnica possível e exequível desde o nascimento, tal como evidenciado nesta amostra, em que se iniciou com sucesso em mais de metade das crianças antes dos seis meses de vida. Permite uma sobrevivência a longo prazo até à possibilidade do transplante renal apesar da morbilidade associada, nomeadamente as peritonites e as complicações da doença renal

  5. [Reported drug allergy among children attending day care centers].

    PubMed

    Martins, Pedro; Belo, Joana; Marques, João; Papoila, Ana Luísa; Caires, Iolanda; Araújo-Martins, José; Pedro, Catarina; Rosado-Pinto, José; Virella, Daniel; Leiria-Pinto, Paula; Neuparth, Nuno

    2014-01-01

    Introdução: A prevalência de alergia a fármacos na população geral não se encontra devidamente caraterizada, existindo poucos estudos publicados que tenham abordado esta situação em crianças com idades inferior a seis anos de idade. Este estudo tem como objetivo principal estimar a prevalência de alergia a medicamentos reportada pelos pais de crianças de infantários de Lisboa e do Porto. Material e Métodos: No âmbito da Fase II do projeto “ENVIRH – Ambiente e Saúde em Creches e Infantários” foi aplicado um questionário sobre alergia a medicamentos aos pais das crianças, recrutadas por amostragem aleatória estratificada dos infantários. Resultados: Foram analisados 1 169 questionários, 52,5% de rapazes. A idade média foi de 3,5 ± 1,5 anos. A prevalência de alergia a medicamentos reportada foi de 4,1% (IC 95%: 3,0 - 5,2%). Os fármacos mais referidos foram os antibióticos (em 27 reações) e os AINEs (em seis reações). Na análise multivariável, a alergia a medicamentos reportada associou-se diretamente com a idade da criança (OR 1,19; IC 95% 1,01 - 1,41) e com a referência a alergia alimentar (OR 3,19; IC95% 1,41 - 7,19) e inversamente com o nível de escolaridade dos pais (OR 0,25; IC95% 0,10 - 0,59). Discussão: Apesar das limitações do estudo, os resultados encontram-se de acordo com o reportado por outros autores e sugerem que a prevalência reportada de alergia a medicamentos seja elevada no grupo etário estudado. Conclusão: Torna-se necessário que situações de alergia a medicamentos reportadas pelos pais sejam devidamente estudadas, no sentido de evitar evicções desnecessárias que possam condicionar opções terapêuticas em futuras situações de doença.

  6. Estudo e aplicação do código de desembaraçamento espectral - Korel - em sistemas triplos

    NASA Astrophysics Data System (ADS)

    Torres, K. B. V.; Vaz, L. P. R.

    2003-08-01

    O código KOREL é uma ferramenta adicional eficiente para a determinação simultânea de parâmetros orbitais espectroscópicos para o desembaraço de espectros individuais de sistemas estelares com até cinco componentes. Estudos já realizados (Torres,KBV,2002, Dissertação de Mestrado DF-ICEx-UFMG) mostram as limitações, aplicabilidade e eficiência do código para sistemas com duas componentes. Apresentamos, neste trabalho, a continuação dos estudos para sistemas com três componentes (sistemas hierárquicos), utilizando espectros sintéticos "gabaritos" de estrelas individuais em órbitas cujos parâmetros são conhecidos "a priori". Geramos os espectros compostos e verificamos como o código reproduz os parâmetros orbitais e espectros individuais em diversas situações físicas. É apresentado, ainda, uma discussão da aplicabilidade do código em sistemas reais como RV Crateris (Machado,ACM,1997, Dissertação de Mestrado DF-ICEx-UFMG), um sistema triplo cujas componentes eclipsantes estão, provavelmente, ainda na fase pré-sequência principal.

  7. [Anogenital Warts in a Major Venereology Clinic: Centro de Saúde da Lapa - Lisbon, 2008 to 2014].

    PubMed

    Gameiro, Ana; Alves, João; Santo, Irene; Azevedo, Jacinta

    2016-02-01

    Introdução: O vírus do papiloma humano é responsável pela infeção sexualmente transmissível mais comum, podendo manifestar--se por um conjunto amplo de doenças, nomeadamente condilomas anogenitais, papilomatose laríngea recorrente, e neoplasias da região anogenital, colo do útero e orofaringe. Estima-se que os condilomas anogenitais afetem 1% da população sexualmente ativa, causados em cerca de 90% pelos genótipos 6 e 11. Material e Métodos: Identificámos os doentes com primeiro diagnóstico de condilomas anogenitais da consulta de doenças sexualmente transmissíveis do Centro de Saúde da Lapa, entre janeiro de 2008 e dezembro de 2014, e caracterizámos os doentes por sexo, orientação sexual, idade, localização das lesões, e número de parceiros nos últimos seis meses. Resultados: Foram identificados 902 indivíduos com primeiro diagnóstico de condilomas anogenitais. Observámos uma diminuição significativa de novos casos nas mulheres com < 19 anos (r = -0,848; p = 0,016), e uma diminuição sem significado estatístico nos homens com < 19 anos e nas mulheres entre os 20 - 24 anos. Discussão: Em outubro de 2008, a vacina quadrivalente (genótipos 6, 11, 16, 18) foi introduzida no plano nacional de vacinação de Portugal, abrangendo as adolescentes com 13 anos, com um catch-up para as de 17 anos. A diminuição de primeiros diagnósticos de condilomas anogenitais nas mulheres, deve-se provavelmente à sua vacinação antes de iniciarem a vida sexual. Conclusão: Este estudo reforça a import'ncia do programa nacional de vacinação para o vírus do papiloma humano.

  8. Electronic structure of bulk AnO2 (An = U, Np, Pu) and water adsorption on the (111) and (110) surfaces of UO2 and PuO2 from hybrid density functional theory within the periodic electrostatic embedded cluster method

    NASA Astrophysics Data System (ADS)

    Wellington, Joseph P. W.; Kerridge, Andrew; Austin, Jonathan; Kaltsoyannis, Nikolas

    2016-12-01

    Generalised gradient approximation (PBE) and hybrid (PBE0) density functional theory (DFT) within the periodic electrostatic embedded cluster method have been used to study AnO2 bulk and surfaces (An = U, Np, Pu). The electronic structure has been investigated by examining the projected density of states (PDOS). While PBE incorrectly predicts these systems to be metallic, PBE0 finds them to be insulators, with the composition of the valence and conduction levels agreeing well with experiment. Molecular and dissociative water adsorption on the (111) and (110) surfaces of UO2 and PuO2 has been investigated, with that on the (110) surface being stronger than on the (111). Similar energies are found for molecular and dissociative adsorption on the (111) surfaces, while on the (110) there is a clear preference for dissociative adsorption. Adsorption energies and geometries on the (111) surface of UO2 are in good agreement with recent periodic DFT studies using the GGA+U approach, and our data for dissociative adsorption on the (110) surface of PuO2 match experiment rather well, especially when dispersion corrections are included.

  9. Ano-Rectal Symptoms of Sexually Transmitted Disease

    PubMed Central

    Warren, Ralph E.

    1987-01-01

    Diseases of the anus and rectum are frequently the outcome of proctogenital and oral-anal sexual activities. These sexually transmitted diseases are more common among homosexual and bisexual men than among heterosexuals. A variety of infectious agents are responsible including viruses, bacteria, spirochetes, helminths, and protozoa. Anal warts, herpetic ulcers, and syphilitic chancres are common anal STDs. Gonorrhea, herpes, and chlamydial organisms are common causes of venereal acute proctitis. Enteric infections such as shigellosis, amebiasis, giardiasis and pinworms can be transmitted by oral-anal contact. Aggressive sexual attempts at auto-eroticism using rectally inserted foreign bodies may cause traumatic proctitis complicated by bacterial peritonitis or perirectal abscesses. PMID:21263807

  10. Management of fistula-in-ano: an introduction.

    PubMed

    El-Tawil, Am

    2011-07-28

    Peri-anal fistulae are a worldwide health problem that can affect any person anywhere. Surgical management of these fistulae is not free from risks. Recurrence and fecal incontinence are the most common complications after surgery. The cumulative personal surgical experience in managing cases with anal fistulae is significantly considered as necessary for obtaining better results with minimal adverse effects after surgery. The purpose for conducting this survey is to facilitate better outcome after surgical interventions in idiopathic anal fistulae' cases.

  11. Apparent Motion of the Sun, Shadows of Objects and Measurement of Time in the View of Seventh Grade Students of Middle School. (Breton Title: Movimento Aparente do Sol, Sombras dos Objetos e Medição do Tempo na Visão de Alunos do Sétimo Ano do Ensino Fundamental.) Movimiento Aparente del Sol, Sombras de los Objetos y Medición del Tiempo en la Visión de Estudiantes del Séptimo Grado del Ciclo Pirmario

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel

    2013-07-01

    The apparent motion of the Sun on the celestial sphere and the behavior of the shadows of objects over time are observable phenomena in everyday life. However, students often do not have a proper understanding of such occurrences, and can even display misconceptions about them. Therefore, we performed a research in order to know students' notions about these subjects and to evaluate the contribution to their understanding brought about by an activity performed with an interactive sundial in an informal learning environment. We investigated the ideas of 43 students from the seventh grade of middle school by applying a test with open questions before and after an activity with an analemmatic sundial, conducted by a monitor. A significant proportion of students were initially unaware of most of the phenomena treated. The intervention performed helped the students to assimilate new concepts, providing the contact with new phenomena and to a lesser degree, the development of explanations about them, indicating an educational potential of this action. However, the contribution to the understanding of some of the ideas explored was small, pointing to the need to make additional observations, studies and discussions. O movimento aparente do Sol na esfera celeste e o comportamento das sombras dos objetos com o passar do tempo são fenômenos observáveis no dia a dia. No entanto, muitas vezes os estudantes não possuem uma compreensão adequada de tais ocorrências, podendo inclusive exibir concepções alternativas a seu respeito. Por isso, efetuou-se uma pesquisa com o intuito de conhecer as noções dos alunos sobre esses temas e avaliar a contribuição para seu entendimento propiciada por uma atividade feita com um relógio de Sol interativo, em um ambiente de ensino informal. Foram investigadas as ideias de 43 alunos do sétimo ano do Ensino Fundamental mediante a aplicação de um teste com questões abertas antes e depois de uma atividade com um relógio de Sol

  12. Estudo exaustivo e sistemático de erros nas provas da olimpíada brasileira de astronomia - resultados preliminares

    NASA Astrophysics Data System (ADS)

    Oliveira, F. S.; Canalle, J. B. G.; Villas da Rocha, J. F.

    2003-08-01

    A Olimpíada Brasileira de Astronomia (OBA) contou, em sua quinta edição, com a participação de mais de 60 mil alunos dos ensinos fundamental e médio de praticamente todo o território nacional. Uma das formas de controle que a sua coordenação nacional possui sobre a correção, levada a cabo pelos professores que as aplicaram, é a do envio, por parte destes professores, das 10 melhores provas de cada um dos três níveis nos quais a Olimpíada é realizada. Assim, e dado ao caráter discursivo das provas da Olimpíada, a sua coordenação nacional dispõe de um vasto acervo sobre as concepções, certas ou erradas, dos alunos que dela participaram. Este conjunto de dados jamais fora explorado até o presente trabalho que pretende ser, neste sentido, inaugural. Nas provas dos níveis I e II da V OBA, que abrangem todo o conjunto do ensino fundamental, uma das questões versava sobre a noção que os alunos tinham sobre como os habitantes da Terra situam-se sobre sua superfície. Fizemos um estudo sistemático das respostas a esta questão. Primeiramente, todas as modalidades de erros foram levantadas; em seguida, realizamos uma distribuição por idade tanto do índice de acerto como da ocorrência e da distribuição de cada erro. Como resultado, obtivemos que, em ambos os níveis: 1) as concepções errôneas não se apresentam distribuídas aleatoriamente; 2) há uma concentração no tipo de erro apresentado; 3) há uma tendência de progressivo acerto com relação à idade quando os dados são considerados em termos nacionais; 4) esta tendência nacional é fraca ou mesmo não é verificada em alguns dos estados com maior patamar de acerto.

  13. 76 FR 60017 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement (SEIS) for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... stockpile remains safe and reliable. Tritium, a radioactive isotope of hydrogen, is an essential component... weapons, tritium decays at a rate of 5.5 percent per year. Accordingly, as long as the Nation relies on a..., transportation of tritiated effluents and/or low level radioactive waste streams, and other applicable...

  14. Fall 2014 SEI Research Review Eliciting Unstated Requirements at Scale (EURS)

    DTIC Science & Technology

    2014-10-28

    introducing ideation • Affinitize visually as well as virtually • Automate identification of relevant ideas to keep others informed of what might...Review Konrad Stoddard Oct. 28, 2014 © 2014 Carnegie Mellon University Contact Information Presenter / Point of Contact Mike Konrad Software

  15. Relation of the lunar power system to the SEI program and to landers

    NASA Astrophysics Data System (ADS)

    Criswell, David R.; Waldron, Robert D.

    The people of Earth will need more than 20,000 billion watts (GWe) of electric power by 2050 for a high level of prosperity. Power needs in the 22nd Century could exceed 100,000 GWe. By 2100 the total quantity of thermal energy used could fully deplete the known inventory (10(exp 7) GWt-Y) of all non-renewable sources on Earth except for deuterium and hydrogen for use in proposed fusion reactors. The labor, capital, and mass of power plants required to produce 1 GWe-Y of energy from present-day power plants is summarized. Fossil and nuclear plants respectively consume 80 to 190 M$ and 12 to 48 M$ of fuel per GWe-Y. The Lunar Power System (LPS) uses solar power bases on the moon to beam electric power to Earth. The LPS in the figure supplies load-following power to rectennas on Earth. Additional solar power conversion units are located across the lunar limb from their respective Earthward transmitting stations. LPS can be augmented by mirrors in polar orbit about the moon. The construction of rectennas on Earth determines the base cost (0.001s$/kWe-H) of LPS power. A manned International Lunar Base (ILB) can accelerate the development of LPS by providing the initial transportation and habitation facilities and base operations. ILB can greatly reduce up front costs and risks by emplacing a moderate scale LPS (1-100 GWe). LPS can accelerate the development of the ILB by providing greater funding than is reasonable to expect for purely scientific research. An international ILB/LPS program can foster world trust and prosperity.

  16. 77 FR 62214 - Travel Management Supplemental Environmental Impact Statement (SEIS), Eldorado National Forest...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ...] [FR Doc No: 2012-25100] DEPARTMENT OF AGRICULTURE Forest Service Travel Management Supplemental... Travel Management Final Environmental Impact Statement (ENF TM FEIS) and Record of Decision (ROD). The... cross country travel. In 2009 a complaint was filed with the Eastern District Federal Court (Court...

  17. 75 FR 16731 - Young Dodge SEIS; Kootenai National Forest, Lincoln County, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... Interface, to decrease the likelihood that fires would become stand-replacing wildfires; (2) Restore... the likelihood that wildfires would become large stand-replacing wildfires, and to restore...

  18. Expenditures for Public Schools in the Southeast. Southeastern Educational Information System Analyses. SEIS Progress Report.

    ERIC Educational Resources Information Center

    Bird, Ronald

    The reluctance of the Southeast to increase educational spending is closely linked to the region's lagging behind the rest of the nation in quality of education and hence in overall standard of living. Six "myths" about educational spending, widely held in the Southeast, are here addressed: (1) That educational expenditures, worthwhile…

  19. Results of SEI Independent Research and Development Projects and Report on Emerging Technologies and Technology Trends

    DTIC Science & Technology

    2005-12-01

    W. Collins Peter Feiler John Goodenough Aaron Greenhouse Jorgen Hansson Alan R. Hevner John Hudak Angel Jordan Rick Kazman Richard C . Linger...Mark G. Pleszkoch Stacy J. Prowell Natasha Sharygina Kurt C . Wallnau Gwen Walton Chuck Weinstock Lutz Wrage December 2005...John Goodenough Aaron Greenhouse Jorgen Hansson Alan R. Hevner John Hudak Angel Jordan Rick Kazman Richard C . Linger Mark G. Pleszkoch Stacy J

  20. Geografia de America Latina. Grados Seis-Diez (Geography of Latin America. Grades Six-Ten).

    ERIC Educational Resources Information Center

    Stanford Univ., CA. Stanford Program on International and Cross Cultural Education.

    This publication, intended for Spanish-speaking students in grades 6-10, has three main objectives. First, it serves as an introduction (or refresher) to basic geographic concepts. Second, it is an examination of the physical and political geography of Latin America. Third, it is designed to help students examine maps in a critical manner. The…

  1. The Watts New? Collection: Columns by the SEI’s Watts Humphrey

    DTIC Science & Technology

    2009-11-01

    included with all reproductions and derivative works. External use. This document may be reproduced in its entirety, without modification, and freely...all of the buzzwords, would like to act strategically, and talks about being the industry leader, managers are hypnotized by their short-term problems

  2. Relation of the lunar power system to the SEI program and to landers

    NASA Technical Reports Server (NTRS)

    Criswell, David R.; Waldron, Robert D.

    1992-01-01

    The people of Earth will need more than 20,000 billion watts (GWe) of electric power by 2050 for a high level of prosperity. Power needs in the 22nd Century could exceed 100,000 GWe. By 2100 the total quantity of thermal energy used could fully deplete the known inventory (10(exp 7) GWt-Y) of all non-renewable sources on Earth except for deuterium and hydrogen for use in proposed fusion reactors. The labor, capital, and mass of power plants required to produce 1 GWe-Y of energy from present-day power plants is summarized. Fossil and nuclear plants respectively consume 80 to 190 M$ and 12 to 48 M$ of fuel per GWe-Y. The Lunar Power System (LPS) uses solar power bases on the moon to beam electric power to Earth. The LPS in the figure supplies load-following power to rectennas on Earth. Additional solar power conversion units are located across the lunar limb from their respective Earthward transmitting stations. LPS can be augmented by mirrors in polar orbit about the moon. The construction of rectennas on Earth determines the base cost (0.001s$/kWe-H) of LPS power. A manned International Lunar Base (ILB) can accelerate the development of LPS by providing the initial transportation and habitation facilities and base operations. ILB can greatly reduce up front costs and risks by emplacing a moderate scale LPS (1-100 GWe). LPS can accelerate the development of the ILB by providing greater funding than is reasonable to expect for purely scientific research. An international ILB/LPS program can foster world trust and prosperity.

  3. Preparation and Properties of Non-Crystalline Glasses in the System Se-I

    DTIC Science & Technology

    2001-06-01

    34Transylvania", 2200-Brasov, Romania Vitreous Sexl-., samples (x=0.1; 0.15; 0.20) have been prepared and studied by thermal analysis, iodometry , X-ray...thermogravimetric curves reveal important loss of material (iodine) of the same order of magnitude as for the losses observed by iodometry measurements. 3.3

  4. Robotic Lunar Rover Technologies and SEI Supporting Technologies at Sandia National Laboratories

    NASA Technical Reports Server (NTRS)

    Klarer, Paul R.

    1992-01-01

    Existing robotic rover technologies at Sandia National Laboratories (SNL) can be applied toward the realization of a robotic lunar rover mission in the near term. Recent activities at the SNL-RVR have demonstrated the utility of existing rover technologies for performing remote field geology tasks similar to those envisioned on a robotic lunar rover mission. Specific technologies demonstrated include low-data-rate teleoperation, multivehicle control, remote site and sample inspection, standard bandwidth stereo vision, and autonomous path following based on both internal dead reckoning and an external position location update system. These activities serve to support the use of robotic rovers for an early return to the lunar surface by demonstrating capabilities that are attainable with off-the-shelf technology and existing control techniques. The breadth of technical activities at SNL provides many supporting technology areas for robotic rover development. These range from core competency areas and microsensor fabrication facilities, to actual space qualification of flight components that are designed and fabricated in-house.

  5. A Software Process Framework for the Software Engineering Institute’s (SEI) Capability Maturity Model

    DTIC Science & Technology

    1994-09-01

    named after the 19th-century economist Vilfredo Pareto , that most effects come from relatively few causes, i.e., 80% of the effects come from 20% of the... Pareto analysis The analysis of defects by ranking causes from most significant to least significant. Pareto analysis is based on the principle

  6. A Software Process Framework for the SEI Capability Maturity Model: Repeatable Level

    DTIC Science & Technology

    1993-06-01

    Vilfredo Pareto , that most effects I come from relatively few causes, i.e., 80% of the effects come from 20% of the possible causes. peer review - A review...to the next maturity level. Using the Pareto principle [Juran88b], the CMM prescribes the "vital few" key process areas to focus on depending on an...or interfacing with the individuals responsible for performing in the topic area. (See train for contrast.) Pareto analysis - The analysis of defects

  7. Fall 2014 SEI Research Review Probabilistic Analysis of Time Sensitive Systems

    DTIC Science & Technology

    2014-10-28

    Osmosis SMC Tool Osmosis is a tool for Statistical Model Checking (SMC) with Semantic Importance Sampling. • Input model is written in subset of C...ASSERT() statements in model indicate conditions that must hold. • Input probability distributions defined by the user. • Osmosis returns the...on: – Target relative error, or – Set number of simulations Osmosis Main Algorithm 1 http://dreal.cs.cmu.edu/ (?⃑?): Indicator

  8. Fall 2014 SEI Research Review Edge-Enabled Tactical Systems (EETS)

    DTIC Science & Technology

    2014-10-29

    distributed collaboration in VREP simulations for 5-12 quadcopters and ground robots • Open-source middleware and algorithms released to community...Integration into CMU Drone-RK quadcopter and Platypus autonomous boat platforms • Presentations at DARPA (CODE), AFRL C4I Workshop, and AFRL Eglin

  9. An Alternative Three-Level Model for Estimating SEIs and Their Stability.

    ERIC Educational Resources Information Center

    Mandeville, Garrett K.

    After a brief review of recent research concerning school effectiveness, this paper proposes an approach to operationalizing school effectiveness that is based on the achievement of students in a school over a period of time. This three-level model does not follow a single cohort of students as they progress through school. Rather, it uses the…

  10. Results of SEI Independent Research and Development Projects and Report on Emerging Technologies and Technology Trends

    DTIC Science & Technology

    2004-10-01

    always feasible. However, today more and more systems have this requirement, including e - commerce systems and mobile embedded systems . For systems to...interfaces—similar to the distributed com- ponent object model (DCOM) or object request brokers (ORBs) based on the CORBA speci- fication. A system or...of automated development based on “ modeling software system families such that, given a particular requirements specification, a highly customized

  11. An interagency space nuclear propulsion safety policy for SEI - Issues and discussion

    NASA Technical Reports Server (NTRS)

    Marshall, A. C.; Sawyer, J. C., Jr.

    1991-01-01

    An interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of Safety Functional Requirements. In addition, the NSPWG reviewed safety issues for nuclear propulsion and recommended top level safety requirements and guidelines to address these issues. Safety topics include reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations. In this paper the emphasis is placed on the safety policy and the issues and considerations that are addressed by the NSPWG recommendations.

  12. [Evolution of residual risk for HIV, HCV and HBV, from 1999 to 2010, in blood donations of the Centro Hospitalar S. João, EPE, Porto, Portugal].

    PubMed

    Koch, Carmo; Araújo, Fernando

    2013-01-01

    risco residual infeccioso de cinco vezes para o vírus da imunodeficiência humana e vírus da hepatite B, e de 32 vezes para o vírus da hepatite C. Se compararmos o período 1991-1998 com o último período do estudo, 2007-2010, ou seja, durante 20 anos, a diminuição é relevante, verificando-se uma diminuição do risco para vírus da imunodeficiência humana, vírus da hepatite B e vírus da hepatite C, na ordem de 19, seis e 54 vezes respectivamente.

  13. [Autism and Early Neurodevelopmental Milestones].

    PubMed

    Ferreira, Xavier; Oliveira, Guiomar

    2016-03-01

    Introdução: A perturbação do espectro do autismo, neste texto também designada por autismo, é uma patologia crónica do neurodesenvolvimento, que se manifesta precocemente na infância por alterações da interação social, comunicação e comportamento repetitivo. Não estando disponíveis biomarcadores específicos, o diagnóstico baseia-se exclusivamente na avaliação clínica. O objetivo deste estudo é verificar quais os marcadores precoces do desenvolvimento psicomotor ou neurodesenvolvimento, que se correlacionam significativamente com a gravidade da clínica central do autismo, quocientes de desenvolvimento e com a função adaptativa. Material e Métodos: Procedemos ao estudo retrospetivo de uma população de 1 572 indivíduos com o diagnóstico de autismo seguidos na Unidade de Neurodesenvolvimento e Autismo do Centro de Desenvolvimento da Criança do Hospital Pediátrico do Centro Hospitalar e Universitário de Coimbra. Analisámos seis marcadores precoces do desenvolvimento psicomotor: idades de aquisição 'da marcha', 'das primeiras palavras', 'das primeiras frases', 'do controlo de esfíncter vesical diurno', 'do controlo de esfíncter vesical noturno' e de início das primeiras queixas. Posteriormente dividimos a amostra em três subgrupos de gravidade clínica segundo a escala Childhood Autism Rating Scale e pesquisamos diferenças significativas entre os três subgrupos relativamente aos seis marcadores definidos. Resultados: O marcador 'idade de aquisição das primeiras frases' foi, de entre os seis, aquele que se correlacionou mais fortemente com as variáveis da clínica de autismo, quocientes de desenvolvimento/inteligência e comportamento ou função adaptativa. Na divisão da amostra em subgrupos de gravidade clínica, foi o de maior gravidade que mostrou idades de aquisição dos marcadores do neurodesenvolvimento mais tardias e idades mais precoces de manifestação das primeiras queixas. Discussão: Este estudo vem demonstrar a

  14. Estudo em microondas do aprisionamento e precipitação de elétrons em explosões solares

    NASA Astrophysics Data System (ADS)

    Rosal, A. C.; Costa, J. E. R.

    2003-08-01

    Uma explosão solar é uma variação rápida e intensa do brilho que ocorre nas chamadas regiões ativas da atmosfera, constituídas por um plasma magnetizado com intensa indução magnética. Os modelos de explosões solares atuais, discutidos na literatura, apresentam características de aprisionamento e precipitação de elétrons em ambientes magnéticos simplificados. Neste trabalho, nos propusemos a separar a emissão dos elétrons aprisionados da emissão dos elétrons em precipitação apenas a partir da emissão em microondas, melhorando portanto o controle sobre o conjunto de parâmetros inferidos. A emissão em microondas da população em precipitação é bastante fraca e portanto da nossa base de dados de 130 explosões observadas pelo Rádio Polarímetro de Nobeyama, em sete freqüências, apenas para 32 foi possível separar as duas componentes de emissão com uma boa razão sinal/ruído. A partir de estudos das escalas de tempo das emissões devidas à variação gradual da emissão no aprisionamento e da variação rápida da emissão dos elétrons em precipitação foi possível obter a separação utilizando um filtro temporal nas emissões resultantes. Em nossa análise destas explosões estudamos os espectros girossincrotrônicos da emissão gradual, a qual associamos provir do topo dos arcos magnéticos e da emissão de variação rápida associada aos elétrons em precipitação. Estes espectros foram calculados e dos quais inferimos que a indução magnética efetiva do topo e dos pés foi em média, Btopo = 236 G e Bpés = 577 G, inferidas das freqüências de pico dos espectros em ntopo = 11,8 GHz e npés = 14,6 GHz com leve anisotropia (pequeno alargamento espectral). O índice espectral da distribuição não-térmica de elétrons d, inferido do índice espectral de fótons da emissão em regime opticamente fino, foi de dtopo = 3,3 e dpés = 3,9. Estes parâmetros são típicos da maioria das análises realizadas em ambiente único de

  15. [Evaluation of hearing in patients with multiresistant tuberculosis].

    PubMed

    Ribeiro, Leandro; Sousa, Claudia; Sousa, Aida; Ferreira, Catarina; Duarte, Raquel; Faria E Almeida, António; Condé, Artur

    2015-01-01

    Introdução: A tuberculose multirresistente e a extensivamente resistente constituem atualmente a principal ameaça ao controlo da tuberculose a nível mundial. O seu tratamento exige o uso de um esquema terapêutico com fármacos de segunda linha por um período mínimo de 20 meses, onde se incluem aminoglicosídeos durante um período de cerca de oito meses. Estes estão associados a alterações cocleovestibulares permanentes. Material e Métodos: Estudo transversal que pretende avaliar a função auditiva em indivíduos que terminaram tratamento por tuberculose multirresistente (com esquema que incluia aminoglicosídeos) no Centro de Referência Regional para a Tuberculose Multirresistente da Sub-Região de Saúde do Norte entre os anos de 2009 e 2012. Os doentes que preencheram os critérios de inclusão foram convocados para a realização de: exame objetivo otorrinolaringológico, audiograma tonal e vocal, otoemissões acústicas por produtos de distorção nas frequências de 2000-5000 Hz e timpanograma. Resultados: Entre 2009 e 2012 foram referenciados 27 casos para o Centro de Referência para a tuberculose multirresistente da Região Norte, tendo-se verificado cinco óbitos. Dos 22 indivíduos convocados, compareceram 11. Estes possuíam idades compreendidas entre os 31 e os 59 anos (41 ± 10). A amicacina foi usada em 80% e a capreomicina nos restantes. Seis (60%) dos utentes estudados apresentaram surdez neurossensorial. As otoemissões acústicas foram negativas em todos os doentes com hipoacúsia neurossensorial, o que confirma a sua origem coclear. Discussão/ Conclusão: Os resultados deste estudo sugerem a necessidade de existir uma monitorização audiológica mais frequente nos indivíduos com tuberculose multirresistente tratados com aminoglicosídeos permitindo detectar mais precocemente a perda auditiva.

  16. [Congenital Heart Disease in Children with Down Syndrome: What Has Changed in the Last Three Decades?

    PubMed

    Dias, Filipa Mestre; Cordeiro, Susana; Menezes, Isabel; Nogueira, Graça; Teixeira, Ana; Marques, Marta; Abecasis, Miguel; Anjos, Rui

    2016-10-01

    Introdução: A prevalência da síndrome de Down tem aumentado nos últimos 30 anos; 55% destas crianças apresentam cardiopatia congénita. Material e Métodos: Estudo retrospetivo longitudinal de coorte; dados clínicos obtidos em bases de dados de 1982 a 2013 com o diagnóstico de síndrome de Down ou trissomia 21 num hospital de referência em cardiologia pediátrica e cirurgia cardíaca. Objetivo: Avaliar a evolução, nas últimas três décadas, dos cuidados cardiológicos prestados às crianças com síndrome de Down ecardiopatia congénita.Resultados: Estudámos 102 doentes com síndrome de Down e cardiopatia congénita submetidos a terapêutica invasiva: cirurgiacardíaca corretiva, paliativa e cateterismo terapêutico. Em doentes referenciados no primeiro ano de vida, a referenciação foi cada vez mais precoce. O diagnóstico mais frequente foi o defeito completo do septo aurículo-ventricular (41%). Verificou-se uma tendência para cirurgia corretiva cada vez mais precoce em doentes abaixo dos 12 meses (p < 0,001). A partir de 2000, a grande maioria dos doentes foi operada antes dos seis meses de idade. As principais complicações cardíacas foram alterações de ritmo e baixo débito e as principais não cardíacas foram pulmonares e infeciosas. A taxa de mortalidade a 30 dias foi de 3/102 casos (2,9%). Dos doentes em follow-up, 89% estão em classe funcional I da NYHA. Discussão e Conclusão: A correção cirúrgica mais precoce verificada nos últimos 15 anos vai ao encontro do proposto na literatura. A taxa de mortalidade a 30 dias verificada é sobreponível aos resultados internacionais. Os doentes com síndrome de Down submetidos a cirurgia corretiva de cardiopatia congénita apresentam uma excelente capacidade funcional a longo prazo.

  17. Impact of preoperative analytical values on post-operative mortality rate of intertrochanteric fractures.

    PubMed

    Borges, Ana; Torres, João; São Simão, Ricardo; Cabral, Abel Trigo; Pinto, Rui

    2014-01-01

    Introdução: A incidência das fraturas intertrocantéricas tem aumentado ao longo dos últimos anos, bem como todos os problemas a elas associados. É importante pesquisar possíveis formas de reduzir quer co-morbilidades, quer a mortalidade pós-operatória. Decidimos avaliar o impacto de alguns valores analíticos pré-operatórios na mortalidade pós-operatória de doentes com fractura intertrocantérica, com idade igual ou superior a 65 anos.Material e Métodos: De todas as fracturas intertrocantéricas admitidas entre Janeiro de 2007 e Maio 2012, 160 doentes foram incluídos no estudo. As variáveis estudadas foram idade, género, tempo de internamento, e dados analíticos, como hemoglobina, contagem de leucócitos e plaquetas, níveis de ureia e creatinina e concentração de sódio plasmática. Informação relativa à mortalidade foi obtida através do registo civil e, considerando um ponto de corte de seis meses após a cirurgia, os doentes foram divididos em dois grupos de acordo com a sua sobrevida. Os testes de Mann-Whitney e Chi-quadrado foram utilizados para estudar a associação entre as nossas variáveis e a sobrevida dos doentes.Resultados: A nossa população apresentava uma idade mediana de 82 anos de idade e uma maioria de mulheres (79,4%). Nos primeiros 6 meses após a cirurgia, 27 doentes dos iniciais 160 (16,1%) faleceram. A mortalidade estava relacionada com valores baixos de hemoglobina, elevados de plaquetas, elevados de creatinina e baixa concentração de sódio plasmático.Conclusão: A taxa de mortalidade pos-operatória da cirurgia da anca é elevada. Os nossos resultados podem ser utilizados parareduzir esta taxa, corrigindo valores analíticos pré-operatórios.

  18. Pediatric Multiple Sclerosis in Portugal: A Multicentre Study.

    PubMed

    Correia, Ana Sofia; Augusto, Luís; Meireles, Joana; Pinto, Joana; Sousa, Ana Paula

    2016-08-01

    Introdução: A esclerose múltipla é habitualmente diagnosticada em adultos jovens mas, mais raramente, pode manifestar-se durante a infância ou adolescência. Os dados sobre a esclerose múltipla pediátrica em Portugal são escassos. O objectivo principal deste estudo é a avaliação das características demográficas, clínicas, laboratoriais e neurorradiológicas da esclerose múltipla de início em idade pediátrica em Portugal. Os objetivos secundários consistem na comparação entre a esclerose múltipla de início na infância e a esclerose múltipla de início na adolescência e na caracterização dos tratamentos prescritos. Material e Métodos: Realizou-se um estudo retrospectivo, observacional e multicêntrico, que consistiu na análise dos dados de todos os doentes com apresentação da EM antes dos 18 anos. Resultados: Incluíram-se 46 doentes (72% do sexo feminino), com uma idade média de diagnóstico de 16,1 anos. Seis casos tiveram início na infância, 40 na adolescência. A esclerose múltipla apresentou-se em 98% dos casos com a forma surto-remissão. O estudo do líquor revelou bandas oligoclonais em 74% dos doentes. A ressonância magnética encefálica mostrou predominantemente lesões supratentoriais (98% dos casos), enquanto que a ressonância medular revelou que o segmento cervical foi o mais frequentemente afectado. Todos os doentes iniciaram terapêutica imunomoduladora (75% com interferão β). Relativamente às diferenças entre os dois grupos etários, encontrámos uma maior proporção de doentes do sexo masculino e com pleocitose no grupo com apresentação na infância. Discussão: Este trabalho fornece novos dados sobre as características da esclerose múltipla pediátrica em Portugal e os resultados são semelhantes aos reportados em outras partes do mundo. Conclusão: Este é o primeiro estudo multicêntrico português sobre a esclerose múltipla com apresentação na infância e adolescência. Mais estudos são necess

  19. Construção de um catálogo de aglomerados abertos para estudo da dinâmica da estrutura espiral da Galáxia

    NASA Astrophysics Data System (ADS)

    Carlos, I. M.; Lépine, J. R. D.

    2003-08-01

    Os aglomerados abertos são objetos de grande valor para o estudo da dinâmica da Galáxia devido esses objetos terem uma faixa de idade relativamente ampla. O trabalho visa estudar a dinâmica da estrutura espiral da Galáxia principalmente através do uso desses aglomerados, uma vez que o estudo da cinemática desses objetos é fundamental para esse objetivo. Nosso grupo trabalha no sentido de construir uma base de dados de aglomerados abertos contendo coordenadas, distância, idade, movimentos próprios e velocidades radiais e já disponibiliza uma nova versão do catálogo de aglomerados abertos o qual é uma compilação de edições anteriores, principalmente Lynga (1987), Mermilliod (1995) e ESO-B (Lauberts 1982). Nossa amostra possui cerca de 1630 aglomerados, mas nem todos os parâmetros acima citados foram determinados em sua totalidade. Para determinarmos esses parâmetros, derivamos as cores intrínsecas das estrelas membro de cada aglomerado a partir de seus tipos espectrais (busca feita no SIMBAD) obtendo assim o excesso de cor individual. A distribuição dos excessos de cor foi então utilizada para derivarmos o avermelhamento médio para cada aglomerado. De maneira similar, os tipos espectrais foram usados para estimar as magnitudes absolutas, e com as magnitudes absolutas e aparentes determinamos a respectiva distribuição do módulo de distância e finalmente a distância. Para determinar as idades foram confeccionados os diagramas cor-magnitude das estrelas de cada aglomerado onde foram superpostas a Seqüência Principal de Idade Zero (ZAMS). Superpomos a ZAMS de Schmidt-Kaler e isócronas de composição solar. Essas isócronas foram usadas para determinação das idades dos aglomerados. Uma vez que não temos ainda resultados finais, apresentamos então alguns diagramas cor-magnitude os quais foram usados para determinação, principalmente, da distância e idade dos aglomerados.

  20. Mixed-Methods Study that Examines Nine Science Teachers' Perceptions of Slooh Robotic Telescope for Teaching Astronomy. (Breton Title: Métodos Mistos de Estudo que Examinam a Percepção de Nove Professores de Ciências sobre o Telescópio Robótico Slooh Para Ensino de Astronomia.) Métodos Mixtos de Estudio que Examinan la Percepcion de Nueve Profesores de Ciencias sobre EL Telescopio Robótico Slooh Para la Enseñanza de la Astronomía

    NASA Astrophysics Data System (ADS)

    Gershun, Daniel C.; Slater, Timothy F.; Berryhill, Katie J.

    2014-07-01

    Although previous studies show that robotic telescopes have the potential to enhance student learning, there is comparatively little research that focuses on teacher perceptions of this technology. This study investigates: "what is the academic merit of using SLOOH robotic telescopes to teach astronomy as perceived by science teachers?" Our sample consists of nine science teachers of students aged 13-18 years. Pre- and post-tests, interviews, and surveys were collected during two weeks of a summer online course about robotic telescopes. While pre and post-tests do not reveal a statistically significant gain in astronomy content knowledge, analysis of qualitative data reveals five themes which describe the most important aspects of using SLOOH according to participants: "Images," "Interface," "Classroom Application," "Instructor Impact," and "Logistical Issues." Analysis of these themes suggests that SLOOH can provide an interactive and social learning environment with capabilities to incorporate crossdisciplinary themes. Embora estudos anteriores mostram que os telescópios robóticos têm o potencial de melhorar a aprendizagem dos alunos, há relativamente pouca investigação focada nas percepções de professores a respeito desta tecnologia. Este estudo investiga: "qual é o mérito acadêmico da utilização de telescópios robóticos Slooh para ensinar astronomia, tal como percebido pelos professores de ciências?" Nossa amostra é composta por nove professores de ciências de estudantes com idades entre 13-18 anos pré e pós-testes, entrevistas, e levantamentos foram coletados durante duas semanas de um curso on-line de verão sobre telescópios robóticos. Enquanto os testes pré e pós não revelaram um ganho estatisticamente significativo no conhecimento do conteúdo astronomia, a análise de dados qualitativos revela cinco temas que descrevem os aspectos mais importantes da utilização Slooh de acordo aos participantes: "Imagens", "Interface", "Aplica

  1. [Congenital Anomalies Detected at Birth in Newborns of Adolescent Women].

    PubMed

    dos Reis, Leandro Valim; Araujo Júnior, Edward; Guazzelli, Cristina Aparecida Falbo; Cernach, Mirlene Cecilia Soares Pinho; Torloni, Maria Regina; Moron, Antonio Fernandes

    2015-01-01

    Introdução: Analisar a prevalência das anomalias congénitas, detetadas no nascimento, entre filhos de gestantes adolescentes, enfatizando os tipos mais comuns e a época do diagnóstico. Material e Métodos: Estudo retrospetivo do tipo censo, no qual foram analisados todos recém-nascidos, vivos ou mortos, com peso superior a 500 g, de mulheres que tiveram o parto no Hospital São Paulo num período de seis anos. Os produtos da conceção portadores de anomalias foram identificados no período pré-natal ou através do exame físico pós-natal, segundo os critérios do Estudo Colaborativo Latino-Americano das Malformações Congênitas. Os resultados são apresentados de forma descritiva através de valores absolutos e relativos, calcula-se a prevalência das anomalias e comparam-se os diferentes grupos recorrendo a testes não paramétricos. Resultados: Foram analisadas 6 257 gestações, das quais 577 resultaram em recém-nascidos com alguma anomalia congénita identificada no nascimento (prevalência de 9,2%). Do total de gestações, 907 eram de adolescentes (idade inferior a 20 anos), para as quais se verificou uma prevalência de anomalias nos recém-nascidos de 9,9%. Comparando os recém-nascidos de adolescentes com os das mulheres com idade superior a 20 anos, apenas se encontrou diferença estatisticamente significativa para a prevalência dos defeitos do tubo neural (p = 0,027). Discussão: Observamos uma alta taxa de partos em adolescentes, acima das taxas dos países desenvolvidos. Observamos também alta frequência de anomalias congénitas em recém-nascidos, provavelmente por sermos um serviço terciário de referência. A elevada prevalência dos defeitos do tubo neural entre grávidas jovens pode ser explicada pela não suplementação pré-concecional de ácido fólico em gravidezes não planeadas, como é característico nas adolescentes.Conclusão: A prevalência e momento do diagnóstico das anomalias congénitas em rec

  2. [Health care associated multidrug-resistant bacteria in a pediatric hospital: five year experience].

    PubMed

    Mação, Patrícia; Lopes, João Casalta; Oliveira, Henrique; Oliveira, Guiomar; Rodrigues, Fernanda

    2013-01-01

    Introdução: Nos últimos anos tem-se assistido a um aumento das infeções por bactérias multirresistentes. Os dados pediátricos no global, e em particular em Portugal, são escassos.Objectivos: Avaliar a evolução das infeções por bactérias multirresistentes associadas aos cuidados de saúde num hospital pediátrico.Material e Métodos: Estudo retrospetivo de incidência efetuado nas enfermarias médicas, cirúrgicas e de cuidados intensivos num hospital pediátrico nível III, entre Janeiro de 2005 e Dezembro de 2009. As bactérias multirresistentes estudadas foram Staphylococcus aureus meticilino-resistente (SAMR), bacilos gram negativos produtores de β-lactamases de espectro expandido (ESBL), Enterococcus spp resistentes à vancomicina (ERV), Pseudomonas aeruginosa multirresistentes (PAMR) e Acinetobacter baumanii resistente aos carbapenems. Foram analisados dados demográficos, clínicos, laboratoriais, terapêuticos e presença de fatores de risco.Resultados: Durante o período de estudo foram identificadas 106 bactérias multirresistentes associadas, correspondentes a 72 crianças, com predomínio do sexo masculino (65,3%). As bactérias multirresistentes mais frequentemente identificadas foram SAMR (35,8%), PAMR (29,2%) e bacilos gram negativos com fenótipo ESBL (17,9%). Destas 106 bactérias multirresistentes, 45 (42,5%) foram identificadas em infeção. Ao longo do período de estudo, a proporção anual de infeções por bactérias multirresistentes variou entre 32,0% em 2006 e 55,6% em 2009 (p = 0,376). A taxa de incidência global de infeção por estas bactérias foi de 0,400 por 1 000 dias de internamento, correspondendo a 0,274 infeções por 100 internamentos, valor que se manteve estável ao longo dos cinco anos. Predominaram as infeções da corrente sanguínea (31,1%), intra-abdominais (20,0%), associadas a cateter venoso central (17,8%) e da pele e tecidos moles (11,1%). Todas as crianças tinham fatores de risco e os mais

  3. 78 FR 16565 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement (SEIS) and To Conduct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... Partnership, Line 67 Capacity Expansion Project SUMMARY: The purpose of this notice is to inform the public... Statement for the proposed Enbridge Energy, Limited Partnership, Line 67 Capacity Expansion Project. Under E...) 647-5947. Project details and environmental information on the Enbridge Energy, Limited...

  4. Understanding CMMI Measurement Capabilities & Impact on Performance: Results from the 2007 SEI State of the Measurement Practice Survey

    DTIC Science & Technology

    2007-11-14

    Measurement in the Organization ML1&DK ML2 ML3 ML4&5 N = 151 N = 84 N = 59 N = 71 Gamma = .73 p < .0001 30% 28% 34% 8% 8% 2% 70% 22% 75% 3% 1...2007 © 2007 Carnegie Mellon University Interpreting the results: The Respondents’ Measurement Roles ML1&DK ML2 ML3 ML4&5 N = 151 N = 84 N = 59 N = 70...Goldenson, 14 November 2007 © 2007 Carnegie Mellon University How Measurement Work is Staffed ML1&DK ML2 ML3 ML4&5 N = 78 N = 60 N = 58 N = 60 p < .006

  5. Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule.

    PubMed

    Fernández, Marisa M; Guan, Rongjin; Swaminathan, Chittoor P; Malchiodi, Emilio L; Mariuzza, Roy A

    2006-09-01

    Superantigens are bacterial or viral proteins that elicit massive T cell activation through simultaneous binding to major histocompatibility complex (MHC) class II and T cell receptors. This activation results in uncontrolled release of inflammatory cytokines, causing toxic shock. A remarkable property of superantigens, which distinguishes them from T cell receptors, is their ability to interact with multiple MHC class II alleles independently of MHC-bound peptide. Previous crystallographic studies have shown that staphylococcal and streptococcal superantigens belonging to the zinc family bind to a high affinity site on the class II beta-chain. However, the basis for promiscuous MHC recognition by zinc-dependent superantigens is not obvious, because the beta-chain is polymorphic and the MHC-bound peptide forms part of the binding interface. To understand how zinc-dependent superantigens recognize MHC, we determined the crystal structure, at 2.0 A resolution, of staphylococcal enterotoxin I bound to the human class II molecule HLA-DR1 bearing a peptide from influenza hemagglutinin. Interactions between the superantigen and DR1 beta-chain are mediated by a zinc ion, and 22% of the buried surface of peptide.MHC is contributed by the peptide. Comparison of the staphylococcal enterotoxin I.peptide.DR1 structure with ones determined previously revealed that zinc-dependent superantigens achieve promiscuous binding to MHC by targeting conservatively substituted residues of the polymorphic beta-chain. Additionally, these superantigens circumvent peptide specificity by engaging MHC-bound peptides at their conformationally conserved N-terminal regions while minimizing sequence-specific interactions with peptide residues to enhance cross-reactivity.

  6. Approaches to Process Performance Modeling: A Summary from the SEI Series of Workshops on CMMI High Maturity Measurement and Analysis

    DTIC Science & Technology

    2010-01-01

    Lockheed Martin Information Systems and Global Services • Neal Mackertich and Michael Campo, Raytheon Integrated Defense Systems • Raymond Kile ...Modeling with Parametric Cost Models (p 53) Kile Used traditional cost models with modifications based on several of the healthy ingredients to pre...Raymond L. Kile , PMP; John Gaffney, PE; Joan Weszka, Lockheed Martin In this presentation Ray Kile discussed the use of parametric cost models (PCMs

  7. Reconnaissance evaluation of Honduran geothermal sites. Una evaluacion por medio de reconocimiento de seis areas geotermicas en Honduras

    SciTech Connect

    Eppler, D.; Fakundiny, R.; Ritchie, A.

    1986-12-01

    Six geothermal spring sites were selected on the basis of preliminary investigations conducted in Honduras over the last decade and were evaluated in terms of their development potential. Of the six, the Platanares and San Ignacio sites have high base temperatures and high surface fluid discharge rates and appear to have the best potential for further development as sources of electrical power. A third site, Azacualpa, has a high enough base temperature and discharge rate to be considered as a back-up, but the logistical problems involved in geophysical surveys make it less attractive than the two primary sites. Of the remaining three sites, Pavana may be a source of direct-use heat for local agricultural processing. Sambo Creek and El Olivar have either severe logistical problems that would impede further investigation and development or base temperatures and flow rates that are too low to warrant detailed investigation at this time.

  8. Catholic Educational Publishing between the Two Wars: The Case of the Publishers SEI of Turin and La Scuola of Brescia

    ERIC Educational Resources Information Center

    Sani, Roberto

    2009-01-01

    Only at the beginning of the Twentieth century, a confessional type of publishing, directed mainly at schools and teachers and devoted, almost exclusively, to publishing textbooks for every level and type of school, came into existence in Italy. In the period between the two World Wars and especially after the Gentile Reform (1923), this type of…

  9. Performance Estimate of Large-Scale Ion Engines for SEI-Type Missions Using C(sub 60) Propellant

    NASA Technical Reports Server (NTRS)

    Mueller, Juergen

    1993-01-01

    Engine performance parameter, such as thrust, efficiency, specific mass, thruster input, power, thrust-to-power ratio and discharge current have been calculated with specific impulse the indupendent variablel.

  10. Seis-Net a Possible Very Broad Band Seismometer for the Future Mars-Net Russian Mission

    NASA Astrophysics Data System (ADS)

    Schibler, P.; Lognonne, P.; Nibut, T.

    2011-12-01

    Introduction: Following the invitation from IKI for participating to the future Russian Mars-Net mission, our objective is to realize a preliminary study for the deployment of a seismometers network, on the surface of Mars. This experiment would be realized thanks to the "basic brick" of the planetary seismometer developed by IPGP: a Very Broad Band (VBB) axis/pendulum adapted to the Mars-Net mission but analog to the one already proposed for other missions (Humboldt-ExoMars, Selene 2, Discovery GEMS). In order to respect, as much as possible, the mass and power budgets of the Mars96/OPTIMISM seismometer, we plan to propose only one axis/pendulum modified in order to become vertical. This adaptation could be, for instance, simply realized by adding an additional mass and modifying the axis tilt. Compared to the seismic sensor proposed for GEMS, there would be a deployment on Mars without any uncoupling from the lander. So, we estimate that the performances of the Mars-Net seismometer (< 0.1 ng/Hz1/2) will be halfway between OPTIMISM (1 ng/Hz1/2) and GEMS (< 0.05 ng/Hz1/2) seismometers. Scientific objectives: Since the projects Mesur/InterMarsNet in 1990 years then NetLander in 2000 years, our knowledge of interior of Mars has progressed. A network mission about 2018-2020 has to take into account these evolutions. However a lot of questions are still open without any answer. Which is the seismic activity of the planet? Which is the average thickness of the crust? Which is the detailed mineralogy of the mantle? Is there thermical heterogeneities inside mantle associated to a remaining of contemporary mantlellic convection? Which is the fine structure of the core? Therefore one of the first objectives of a network mission is the seismic discovery of Mars. That means, in particularly, to obtain for the first time the quantification of the contemporary seismic activity of the planet and the determination of the absolute thickness of the crust. That will be possible with the first station. But, of course, with the deployment of other stations it will be possible to inverse more elaborated models of the internal structure of Mars. Instrument description: The heritage, at IPGP, of planetary seismometers was often presented. Our accommodation study will be, obviously, based on this heritage. The idea is to reuse our "basic brick", that means the recurrent pendulum of ExoMars mission by aiming the same performances in terms of resolution. On the other hand, we will aim the OPTIMISM-Mars96 specifications in terms of mass, volume and power budgets. Taking in account the preliminary lander mass budget, we will propose only one axis, by using an oblique VBB axis and by tilting it until its sensibility axis became vertical. We would bring back the gravity center of the whole on the sensibility axis by adding a 50g mass on OG axis (which will become horizontal).

  11. "Wenn ich leben soll, so sei es mit dir!" The relationship of father and son in Goethe's "Wilhelm Meisters Wanderjahre".

    PubMed

    Lee, Charlotte

    2011-01-01

    The relationship between father and son is a highly nuanced and persistent theme in Goethe's late novel Wilhelm Meisters Wanderjahre, but has received relatively little critical attention. Drawing on various aspects of the text, from the relationship between Wilhelm and his own son Felix, to the theme of migration from the ‘fatherland’, this essay contends that the relationship of the younger generation to the older traces a pattern of departure and return. The development in the son of an identity distinct and independent from that of the father is a preoccupation of the earlier chapters of the Wanderjahre in particular; but this process of individuation tends to be accompanied in the novel by continued, even increased, identification with the father, which may be conscious or unconscious. All the various stages of this fluctuating relationship are telescoped into a few rich, enigmatic images in the novel's closing scene, in which the threat of separation and the desire for proximity are held in suspension.

  12. Buen Comienzo, Buen Futuro: El Bebe de Seis Meses (Healthy Start, Grow Smart: Your Six-Month Old).

    ERIC Educational Resources Information Center

    Department of Agriculture, Washington, DC.

    Distributed by the U.S. Departments of Agriculture, Education, and Health and Human Services, this Spanish-language pamphlet provides parents with information and advice about their infants in the sixth month of life. Following a brief description of developmental characteristics at this age, the pamphlet offers advice on a variety of topics,…

  13. Early SEI milestones - Underwater habitats and Antarctic research outposts as analogs for long duration spaceflight and lunar and Mars outposts

    NASA Technical Reports Server (NTRS)

    Rummel, John D.; Wharton, Robert A.; Andersen, Dale T.; Mckay, Christopher P.

    1992-01-01

    The use of analog environments for space research is considered focusing on underwater habitats and Antarctic research sites as analogous settings to long-duration space flight. It is pointed out that the use of these earth analogs can provide engineers, scientists, and future crew members with critical 'mission' experience at a relatively low cost.

  14. [Assessment of Hepatitis C Virus Diversity in Addition to the Frequency of Genotypes in Samples Analyzed Between 2009 and 2014 at the Reference Laboratory of National Health Institute Dr. Ricardo Jorge].

    PubMed

    Pádua, Elizabeth; Avó, Ana Patricia; Almeida, Catarina; Água Doce, Ivone; Cortes Martins, Helena

    2015-01-01

    Introdução: A identificação dos genótipos do vírus da hepatite C foi essencial para o prognóstico e tratamento dos doentes crónicos durante os últimos anos. Foram objetivos deste estudo conhecer a frequência de genótipos do vírus da hepatite C nos últimos seis anos, e revelar o contributo de um ensaio in-house para caracterização molecular do vírus. Material e Métodos: A genotipagem do vírus da hepatite C por LiPA foi realizada em 923 amostras, maioritariamente provenientes de indivíduos do sexo masculino. A subtipagem do vírus da hepatite C pelo ensaio in-house com alvo nas regiões Core/E1 e/ou NS5B foi efetuada em 112 amostras. Resultados: Observámos elevada prevalência do genótipo 1 (56,6%), sendo a frequência do subtipo 1a quatro vezes superior ao subtipo 1b. Todos os casos de genótipo 3 (27,5%) foram classificados em subtipo 3a. Nas infeções pelo genótipo 4 (12,9%), identificaram-se os subtipos 4a (65,5%), 4d (31%), 4b (1,7%) e 4c (1,7%). Foram identificadas a RF1_2k/1b, recombinantes intragenótipo 2 e potenciais infeções mistas na população analisada. Discussão: Os subtipos mais prevalentes, 1a e 3a, estão descritos como comuns em utilizadores de drogas injetáveis. Apesar da maioria das amostras analisadas corresponder a reclusos (78,4%), não podemos excluir eventuais comportamentos de risco associados ao consumo de drogas ilícitas. Conclusões: A prevalência elevada do subtipo 1a, a frequência e diversidade do genótipo 4 e a identificação de vírus geneticamente recombinados, sugerem alteração do padrão molecular vírus da hepatite C descrito no passado. O ensaio in-house implementado revelou ser útil para a correta classificação do vírus da hepatite C e melhoria do conhecimento sobre a diversidade do vírus em circulação no país.

  15. [PRAdA intervention: effects on weight of dietary intervention among treated hypertensive Portuguese natives and African immigrants].

    PubMed

    Peixoto, Catarina; Carrilho, Gisela; Alarcão, Violeta; Guerra, Filipa; Simões, Rui; Fernandes, Milene; Nicola, Paulo; Guiomar, Sofia; Nogueira, Paulo; Rocha, Evangelista

    2014-01-01

    Introdução: Perdas de peso melhoram o controlo da tensão arterial em indivíduos hipertensos. As intervenções comportamentais para a perda de peso parecem ser menos eficazes nos imigrantes de origem africana (IOA). Os principais objetivos foram avaliar os efeitos no peso de uma intervenção alimentar em hipertensos nativos de origem portugueses (NOP) e IOA; identificar fatores de sucesso na perda de peso; avaliar a evolução dos conhecimentos e adesão às recomendações alimentares. Material e Métodos: Foram selecionados aleatoriamente hipertensos medicados seguidos nos cuidados de saúde primários para um estudo de duas fases, observacional (15 meses) e de intervenção comportamental (seis meses). Os participantes foram divididos em dois grupos: IOA e NOP. Foram dadas recomendações alimentares e de estilos de vida em sessões individuais presenciais e telefónicas. Resultados: Dos 110 participantes, com IMC médio de 31,6 ± 3,7 kg/m2 e idade média 61,3 ± 10,0 anos, 60 eram imigrantes. Durante a intervenção os NOP perderam 1,4 ± 2,7% do peso e os IOA 0,8 ± 3,6%, sendo a perda superior comparativamente com a fase observacional. Ser do sexo masculino e consumir pelo menos duas porções de lacticínios magros por dia associou-se a maior perda de peso durante a intervenção, independentemente da idade e origem. Houve um aumento significativo no número de recomendações dietéticas conhecidas e cumpridas, com os NOP a cumprirem em média mais recomendações. Discussão: A intervenção foi bem sucedida relativamente à perda de peso, especialmente no grupo dos NOP, confirmando outros estudos. Conclusão: A intervenção aumentou os conhecimentos e adesão às recomendações, realçando a pertinência da educação alimentar, culturalmente adaptada, nos cuidados de saúde primários.

  16. Analisis de las Condiciones de Salud del Nino de 0-6 anos en Honduras.

    ERIC Educational Resources Information Center

    Matamoros, Douglas Alberto

    1987-01-01

    Examines the National Pediatric Service and the research program of the Maternity-Infant-Hospital-School in Honduras. Reports that health conditions of young children (birth to six years) in Honduras are appalling and that available funds for health services are inadequate, reflecting the country's economic and social crisis. (NH)

  17. Consideraciones medicas y psicologicas en ninos de 5 y 6 anos de 6 guarderias infantiles

    ERIC Educational Resources Information Center

    DeSilva, Milagros Guerra; DeViloria, Carmen Leon

    1975-01-01

    This study assessed the effect of attendance at state kindergartens of a group of 181 five- and six-year-olds from low socioeconomic backgrounds. The effects of a supplemental nutritional program as well as the children's attitudes toward attendance were considered. (MS)

  18. Reading: Birth to Age 5 = La Lectura: Desde El Nacimiento Hasta Los 5 Anos

    ERIC Educational Resources Information Center

    Learning Point Associates / North Central Regional Educational Laboratory (NCREL), 2005

    2005-01-01

    Besides a change in the expectations of parents, other shifts are occurring in society that impact the youngest children (Bowman, Donovan, & Burns, 2000): (1) More women are in the workforce than ever before, which means more children are in child care or preschool; (2) There is increasing evidence of, and conviction from educators, that preschool…

  19. Anorectal abscess and fistula-in-ano: evidence-based management.

    PubMed

    Rizzo, Julie A; Naig, Anna L; Johnson, Eric K

    2010-02-01

    The management of anorectal abscess and anal fistula has changed markedly with time. Invasive methods with high resulting rates of incontinence have given way to sphincter-sparing methods that have a much lower associated morbidity. There has been an increase in reports in the medical literature describing the success rates of the varying methods of dealing with this condition. This article reviews the various methods of treatment and evidence supporting their use and explores advances that may lead to new therapies.

  20. Boletin de Informacion Educativa, Ano 2, No. 4 (Educational Information Bulletin, Volume 2, No. 4).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  1. Boletin de Informacion Educativa, Ano 2, No. 3. (Educational Information Bulletin, Volume 2, No. 3).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  2. Boletin de Informacion Educativa, Ano 3, No. 5 (Educational Information Bulletin, Volume 3, No. 5)

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  3. Boletin de Informacion Educativa, Ano V, No. 9 (Educational Information Bulletin, Volume V, No. 9).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  4. Boletin de Informacion Educativa, Ano III, No. 7 (Educational Information Bulletin, Volume III, No. 7).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  5. 450 Years of Chicano History in Pictures/450 Anos del Pueblo Chicano.

    ERIC Educational Resources Information Center

    Chicano Communications Center, Albuquerque, NM.

    For use with junior and senior high school students, this book presents more than 250 drawings and pictures, with an introduction and brief texts in English and Spanish, depicting 450 years of Chicano history. The book covers: Mexico before the Spanish Conquests, Spain's colonization of the Southwest, the United States war on Mexico, events in the…

  6. Boletin de Informacion Educativa, Ano III, No. 6 (Educational Information Bulletin, Volume III, No. 6).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  7. The Shadow of a Gnomon Along a Year: Routine Observations and Teaching of Apparent Motion of the Sun and the Four Seasons. (Spanish Title: La Sombra de un Gnomon lo Largo de un Año: Observaciones de Rutina y la Enseñanza del Movimiento Aparente del Sol y Las Cuatro Estaciones.) A Sombra de um Gnômon ao Longo de um Ano: Observações Rotineiras e o Ensino do Movimento Aparente do Sol E das Quatro Estações

    NASA Astrophysics Data System (ADS)

    Trogello, Anderson Giovani; Danhoni Neves, Marcos Cesar; de Carvalho Rutz da Silva, Sani

    2013-12-01

    , al solsticio de junio, al equinoccio de septiembre y al solsticio de diciembre. Además, se dictaron clases teóricas en la sala de aula. Estos métodos buscaron construir conceptos en torno al movimiento aparente del Sol y la sucesión de las estaciones. Teniendo en cuenta los resultados de las actividades se aplicó una evaluación cuyos datos demuestran la existencia de un aprendizaje deseado por los estudiantes en cuanto a: el reconocimiento de los puntos cardinales, la descripción del movimiento solar aparente y la aparición de las estaciones y su alternancia a partir de observaciones astronómicas visuales sin instrumentos. Muitas concepções alternativas são reconhecidas entre os diversos grupos de estudantes, em especial nos da educação básica. Dentre elas, o movimento aparente do Sol, por mais quotidiano que seja, proporciona variadas interpretações. Deste modo, observar e registrar o movimento dos astros na abóboda celeste é uma tarefa necessária ao ensino de Astronomia. O trabalho que ora se apresenta propõe a apresentação dos resultados da observação do movimento aparente do Sol por intermédio da marcação da sombra de um gnômon vertical por alunos de uma turma do sexto ano do ensino fundamental de uma escola do campo do Paraná. O projeto em si ocorreu em quatro etapas, em datas próximas do equinócio de março, do solstício de junho, do equinócio de setembro e do solstício de dezembro. Além disso, foram desenvolvidas aulas teóricas em sala de aula. Tais métodos buscaram construir conceitos em torno da movimentação aparente do Sol e da alternância das estações do ano. Diante dos resultados provenientes das atividades desenvolvidas foi aplicada uma avaliação e os dados demonstraram um aprendizado desejado dos alunos quanto: ao reconhecimento dos pontos cardeais; à descrição do movimento solar aparente e a ocorrência das estações do ano e sua alternância a partir de observações astronômicas a olho nu.

  8. Pulmonary Embolism in Ambulatory Oncologic Patients.

    PubMed

    Silva, Patrícia; Rosales, Maria; Milheiro, Maria João; Santos, Luísa L

    2015-01-01

    Introdução: A associação entre a doença oncológica e a doença tromboembólica venosa é conhecida. O doente oncológico apresenta um risco de evento trombótico seis a sete vezes superior à população em geral. O tromboembolismo pulmonar é uma importante causa de morbilidade e mortalidade neste grupo de doentes, encontrando-se a sua prevalência subestimada. Material e Métodos: Estudo retrospetivo de todos os episódios de tromboembolismo pulmonar referenciados num período de cinco anos. Selecionaram-se os doentes oncológicos em regime de ambulatório, tendo sido revistos os dados demográficos, fatores de risco, presença de sintomatologia ao diagnóstico, estratificação de risco de doença tromboembólica venosa pelo modelo de Khorana, probabilidade de mortalidade aos 30 dias e sobrevivência global. O trabalho elaborado está de acordo com a declaração de Helsínquia. Resultados: Avaliaram-se 186 doentes, 55,9% do sexo feminino, mediana de idade de 64 anos. As neoplasias mais prevalentes foram a colo-rectal (24,2%) e a pulmonar (17,7%), sendo que a maioria apresentava metástases (66,1%) ou realizaram quimioterapia (69,4%). O tromboembolismo pulmonar foi um achado imagiológico em 69,4%, sendo que nenhum dado clínico analisado no nosso estudo mostrou ter significado estatístico na apresentação de tromboembolismo pulmonar com sintomatologia clínica evidente. Observou-se uma mortalidade aos 30 dias resultante do tromboembolismo pulmonar de 7,5%, tendo-se verificado que os doentes sintomáticos apresentaram uma sobrevivência média inferior relativamente aos assintomáticos (12 vs. 20 meses; p = 0,029). A aplicação retrospetiva do modelo preditivo de Khorana para doença tromboembólica venosa nos doentes sob quimioterapia permitiu identificar 11% dos indivíduos em alto risco. Discussão: O tromboembolismo pulmonar foi um achado imagiológico na maioria dos doentes, sendo que nenhuma variável clínica se associou à presença ou aus

  9. [Meningococcal disease admissions in a paediatric intensive care unit].

    PubMed

    Mação, Patrícia; Januário, Gustavo; Ferreira, Sofia; Dias, Andrea; Dionísio, Teresa; Pinto, Carla; Carvalho, Leonor

    2014-01-01

    Introdução: A infecção meningocócica tem uma elevada mortalidade e morbilidade em crianças. O tratamento agressivo do choque, a referenciação precoce, o transporte secundário especializado e a vacinação são factores com impacto potencial na redução da mortalidade. Foram objectivos caracterizar as crianças com doença invasiva meningocócica admitidas em cuidados intensivos, avaliar parâmetros de gravidade e mortalidade. Material e Métodos: Estudo observacional, cujo método de colheita de dados foi retrospectivo. Foram constituídos dois períodos, de seis anos cada, de acordo com o ano de admissão (A: 2000-2005 e B: 2006-2011) e nestes compararam-se índices de gravidade, disfunção orgânica e mortalidade. Resultados: Foram admitidas 70 crianças com doença invasiva meningocócica. Quando comparadas com as outras causas verificouse uma redução nas admissões por doença invasiva meningocócica (período A: 3,4%; período B: 1,5%; p = 0,001). A ocorrência de meningite foi de 41% no período A e de 29% no período B (p = 0,461). Tiveram púrpura rapidamente progressiva 78% no período A e 50% no período B (p = 0,0032). As crianças do período A tiveram disfunção multi-órgão (80%), coagulação intravascular disseminada (76%) e coma (22%) mais frequentemente que as crianças do período B (29%, 29%, 0%; p < 0,05). A mortalidade foi 26% no período A e 0% no período B (p = 0,006) e a mortalidade estandardizada pelo PRISM foi 1,3 e 0 no período A e B respectivamente. Discussão: A redução do número de admissões por doença menigocócica invasiva pode ser explicada pela introdução da vacina anti-meningocócica C em 2006. Pensa-se que a redução da mortalidade observada, possa ser atribuível à melhoria da estabilização inicial e ao transporte secundário. Conclusão: Nos últimos anos houve uma redução significativa no número de admissões e na mortalidade por doença invasiva meningocócica.

  10. The Role of Electrolyte Upon the SEI Formation Characteristics and Low Temperature Performance of Lithium-Ion Cells With Graphite Anodes

    NASA Technical Reports Server (NTRS)

    Smart, M. C.; Ratnakumar, B. V.; Greenbaum, S.; Surampudi, S.

    2000-01-01

    Quarternary lithium-ion battery electrolyte solutions containing ester co-solvents in mixtures of carbonates have been demonstrated to have high conductivity at low temperatures (< -20C). However, in some cases the presence of such co-solvents does not directly translate into improved low temperature cell performance, presumably due to the formation of ionically resistive surface films on carbonaceous anodes. In order to understand this behavior, a number of lithium-graphite cells have been studied containing electrolytes with various ester co-solvents, including methyl acetate (MA), ethyl acetate (EA), ethyl propionate (EP), and ethyl butyrate (EB). The charge/discharge characterization of these cells indicates that the higher molecular weight esters result in electrolytes which possess superior low temperature performance in contrast to the lower molecular weight ester-containing solutions, even though these solutions display lower conductivity values.

  11. Using the Social Enterprise Intervention (SEI) and Individual Placement and Support (IPS) models to improve employment and clinical outcomes of homeless youth with mental illness1

    PubMed Central

    Ferguson, Kristin M.

    2013-01-01

    Prior research reveals high unemployment rates among homeless youth. The literature offers many examples of using evidence-informed and evidence-based supported employment models with vulnerable populations to assist them in obtaining and maintaining employment and concurrently addressing mental health challenges. However, there are few examples to date of these models with homeless youth with mental illness. The purpose of this article was thus to describe a methodology for establishing a university-agency research partnership to design, implement, evaluate, and replicate evidence-informed and evidence-based interventions with homeless youth with mental illness to enhance their employment, mental health, and functional outcomes. Data from two studies are used to illustrate the relationship between vocational skill-building/employment and mental health among homeless youth. The article concludes with a discussion of the implications of conducting community-based participatory employment and clinical intervention research. The author highlights the opportunities and tensions associated with this approach. PMID:24294127

  12. Using the Social Enterprise Intervention (SEI) and Individual Placement and Support (IPS) models to improve employment and clinical outcomes of homeless youth with mental illness.

    PubMed

    Ferguson, Kristin M

    2013-09-01

    Prior research reveals high unemployment rates among homeless youth. The literature offers many examples of using evidence-informed and evidence-based supported employment models with vulnerable populations to assist them in obtaining and maintaining employment and concurrently addressing mental health challenges. However, there are few examples to date of these models with homeless youth with mental illness. The purpose of this article was thus to describe a methodology for establishing a university-agency research partnership to design, implement, evaluate, and replicate evidence-informed and evidence-based interventions with homeless youth with mental illness to enhance their employment, mental health, and functional outcomes. Data from two studies are used to illustrate the relationship between vocational skill-building/employment and mental health among homeless youth. The article concludes with a discussion of the implications of conducting community-based participatory employment and clinical intervention research. The author highlights the opportunities and tensions associated with this approach.

  13. Peak position differences observed during XPS sputter depth profiling of the SEI on lithiated and delithiated carbon-based anode material for Li-ion batteries

    NASA Astrophysics Data System (ADS)

    Oswald, S.; Hoffmann, M.; Zier, M.

    2017-04-01

    The ability of delivering chemical information from peak shift phenomena has ever since made X-ray photoelectron spectroscopy (XPS) an ideal tool for material characterization in Li-ion batteries (LIB). Upon investigation, charging is inevitable as most of the chemical species involved are non-conducting. Thus, the binding energy (BE) scale must be corrected to allow an accurate interpretation of the results. This is usually done using the peak position of the ubiquitous surface carbon contamination detectable for all Li-ion battery relevant materials. We herein report on the occurrence of peak shift phenomena that can be observed when investigating surface layers on graphite anodes using sputter depth-profiling. These shifts, however, are not related to classical static electric charging, but are depending on the state of charge (lithiation) of the anode material. The observations presented are in agreement with previous findings on other Li-containing materials and are obviously caused by the presence of Li in its elemental state. As aging and failure mechanisms in LIBs are closely linked to electrolyte reaction products on electrode surfaces it is of high importance to draw the correct conclusions on their chemical origin from XP spectra. In order to avoid misinterpretation of the BE positions, implanted Ar can be used for identification of relevant peak positions and species involved in the phenomena observed.

  14. SEI Program Plans: 1996-2000. Volume 1. Five-Year Strategic Plan. Volume 2. One-Year Plans/Proposals.

    DTIC Science & Technology

    1996-01-01

    architecture for a family of sys- tems. The Feature-Oriented Domain Analysis ( FODA ) method looks primarily at "user-visible" aspects of a domain. The...features" of FODA . The add-on task will formally describe all aspects contributing to product line understanding and building. Activity 2: Domain...EDCS EPRI ESC ETRB FAA FEAST FODA FTP HIC IEEE IP IPD IPI IPPD ISO/IEC ITSM JAST JLC JPO KPA K-SAV MBSE MCC MEL MICOM MIT

  15. [Fibrinolytics in the Treatment of Complicated Pleural Effusions].

    PubMed

    Coelho, Ana; Coelho, Margarida; Pereira, Joana; Lavrador, Vasco; Morais, Lurdes; Carvalho, Fátima

    2016-11-01

    Introdução: A instilação intrapleural de fibrinolítico, no tratamento dos derrames pleurais parapneumónicos complicados, tem demonstrado resultados equivalentes ao tratamento cirúrgico. Este estudo foi realizado para avaliar e descrever os resultados da aplicaçãode fibrinolítico no tratamento de derrame pleural parapneumónico complicado, nos doentes seguidos no nosso hospital. Material e Métodos: Revisão retrospetiva, entre janeiro de 2005 e dezembro de 2013, dos doentes (idade superior a um mês e inferior a 18 anos) com diagnóstico de derrame pleural parapneumónico complicado, submetidos a colocação de dreno torácico e instilação intrapleural de fibrinolítico. Resultados: Identificaram-se um total de 37 doentes. A duração média do internamento foi de 17 ± 7,60 dias. Na maioria dos doentes (89,2%) o dreno torácico foi colocado nas primeiras 48 h após admissão, com seis dias de média de drenagem. Verificou-se falência terapêutica em 2,7% dos casos, por recidiva do derrame. Este doente foi submetido a toracoscopia videoassistida com necessidade de conversão do procedimento para toracotomia. A evolução clínica foi favorável em 96,9% dos casos. Discussão: Na nossa revisão a taxa de sucesso terapêutico encontra-se dentro do esperado, com uma percentagem de falência inferior ao descrito na literatura. Apresentamos a instilação intrapleural de fibrinolítico e a toracoscopia videoassistida num mesmo protocolo de atuação, tendo como primeira linha terapêutica o fibrinolítico. Conclusão: A opção terapêutica apresentada teve uma baixa taxa de falência e permitiu evitar um procedimento cirúrgico mais agressivo. Consideramos que esta é uma opção de tratamento eficaz e que, na nossa amostra, cursou com uma baixa taxa de sequelas.

  16. A Influência da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos

    NASA Astrophysics Data System (ADS)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2006-08-01

    O universo em que vivemos possui segredos jamais imaginados pelo homem, fruto da pequena proporção que ocupamos diante de um cosmos infinito. A astronomia funciona como um instrumento que sacia a sede humana em desvendar esses segredos, estudando as galáxias, quasares, pulsares além da existência de todos os elementos que preenchem o espaço cósmico, o vácuo, não mais vazio como se pensou em outros tempos. A mídia explora esse campo de forma mística e também científica. A difusão adequada e dentro dos padrões educacionais vigentes, de conceitos astronômicos, se faz necessária, devido sua presença nos conteúdos escolares, centros de ciência e na mídia, de modo geral. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros introduziu conceitos astronômicos desde a pré-escola até o Ensino Médio. Num estudo realizado com 1.032 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um questionário que abordava conheciment os básicos em astronomia, como estes foram adquiridos e qual era a infra-estrutura oferecida pela escola: para 66,2% dos entrevistados o professor já fez alguma apresentação a respeito de astronomia. O presente estudo revelou também que 44,5% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 28,1% através da televisão e 27,4% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio na forma em que os alunos obtiveram seus conhecimentos astronômicos, a mídia ainda explora e muitas vezes desperta o interesse pela astronomia com assuntos que não fazem parte de nosso cotidiano como, por exemplo, o homem na Lua, os projetos espaciais e a primeira viagem de um astronauta brasileiro no espaço. Porém, em certos casos, a mídia pode promover conhecimentos incompletos ou mesmo equivocados sobre os conceitos que envolvam

  17. [Pulmonary carcinoid: analysis of a single institutional experience and prognostic factors].

    PubMed

    Correia, Silvia da Silva; Pinto, Carlos; Bernardo, João

    2014-01-01

    IntroduçÉo: Os tumores carcinóides pulmonares sÉo tumores raros com origem nas células neuro-endócrinas do pulmÉo. Classificam-se de acordo com os critérios da OMS em carcinóides típicos ou atípicos. Quando comparados com outros tipos de neoplasia pulmonar, os tumores carcinóides apresentam melhor prognóstico.Objetivos: CaracterizaçÉo dos doentes com diagnóstico histológico de tumor carcinóide observados numa instituiçÉo. Análise dos fatores que influenciaram o prognóstico.Material e Métodos: Análise retrospetiva incluindo todos os doentes com diagnóstico histológico de tumor carcinóide pulmonar durante um período de 11 anos numa instituiçÉo. Os tumores foram classificados em típicos e atípicos de acordo com a classificaçÉo da OrganizaçÉo Mundial de Saúde de 2004. O estadiamento foi feito com base na classificaçÉo TNM de 2009 para o carcinoma do pulmÉo de nÉo pequenas células: T (Tumor); N (Ganglionar); M (Metástase).Resultados: Foram incluídos 59 doentes: 53 carcinóides típicos e seis carcinóides atípicos. Destes, 90% foram submetidos a cirurgia. O follow-up médio foi de 57 meses. A mortalidade operatória foi de 2% (n = 1) tratando-se de cirurgia paliativa para um doente em estádio IV. Em 49 doentes nÉo se verificou envolvimento ganglionar (N0), um doente apresentava doença N1, oito doença N2 e um doente doença N3. A sobrevivência global aos cinco anos foi de 79,2%: 80,2% nos carcinóides típicos e 66,7% nos carcinóides atípicos (p < 0,05). Nos doentes T1, a sobrevivência foi de 88,1% e de 58,2% nos T2-T4 (p < 0,01). Nos doentes N0 a sobrevivência aos cinco anos de 89,7% e de 36% para os doentes N1-N3 (p < 0,001). Os doentes com doença M0 apresentaram uma sobrevivência aos cinco anos de 85,9% sendo de 0% nos doentes M1 (p < 0,01). Dos 11 doentes que necessitaram de quimioterapia adjuvante, 45,4% eram carcinóides atípicos.DiscussÉo: Na nossa série, a cirurgia no tumor carcinóide pulmonar demonstrou

  18. Como ayudar a su hijo durante los primeros anos de la adolescencia: Para los padres con ninos entre las edades de 10 a 14 anos (Helping Your Child through Early Adolescence: For Parents of Children from 10 through 14).

    ERIC Educational Resources Information Center

    Paulu, Nancy

    Recognizing that parents and families can greatly influence the development of their 10- through 14-year-olds, this Spanish-language booklet is part of a national effort to provide parents with the latest research and practical information to help them support their children both at home and in school. The booklet is organized in 13 sections…

  19. Desafios que Enfrentaran las Administraciones Universitarias en los Proximos Anos (Challenges for University Administration in the Years Ahead).

    ERIC Educational Resources Information Center

    Valle, Victor M.

    Ten important issues surround the challenges that Latin American university administrations will face in the near future. Those issues are: (1) the importance of administration to higher education and the need for analyzing situations, resolving problems, making decisions, and communicating at all administrative levels; (2) the uniqueness of…

  20. El curriculo creativo para ninos de cero a tres anos (The Creative Curriculum for Infants and Toddlers).

    ERIC Educational Resources Information Center

    Dombro, Amy Laura; Colker, Laura J.; Dodge, Diane Trister

    Stemming from the core idea that infant and toddler care should be based on building relationships, this curriculum in Spanish-language version provides a foundation for staff development. Section 1, "Why a Curriculum for Infants and Toddlers?" examines key quality indicators, discusses curriculum components, describes how to use the…

  1. Informacion Bibliografica: Ano 3, Num. 9, Enero-Febrero, 1972 (Bibliographic Information: Volume 3, Number 9, January-February 1972).

    ERIC Educational Resources Information Center

    Martinez Martinez, Antonio L., Ed.

    This bulletin contains several articles on various topics concerning information science. The first article is a report on the November 1971 Seminar on Documentation and Pedagogical Information in Latin America held in Panama. The second article, entitled "Informatica," provides a discussion of information science by three Soviet writers;…

  2. Boletin de Informacion Educativa, Ano VI, No. 10/11 (Educational Information Bulletin, Volume VI, No. 10/11).

    ERIC Educational Resources Information Center

    Ministerio de Educacion y Cultura, Santa Fe (Argentina). Centro de Documentacion e Informacion Educativa de la Provincia de Santa Fe.

    This information bulletin is published by the Documentation and Educational Information Center in the Argentine province of Santa Fe. The bulletin reports on educational developments in the province and abroad, educational problems, statistics, legislation, documentation and information techniques, and information from international organizations.…

  3. Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker

    PubMed Central

    Ta, Chau M; Adomaviciene, Aiste; Rorsman, Nils J G; Garnett, Hannah

    2016-01-01

    Background and Purpose Calcium‐activated chloride channels (CaCCs) play varied physiological roles and constitute potential therapeutic targets for conditions such as asthma and hypertension. TMEM16A encodes a CaCC. CaCC pharmacology is restricted to compounds with relatively low potency and poorly defined selectivity. Anthracene‐9‐carboxylic acid (A9C), an inhibitor of various chloride channel types, exhibits complex effects on native CaCCs and cloned TMEM16A channels providing both activation and inhibition. The mechanisms underlying these effects are not fully defined. Experimental Approach Patch‐clamp electrophysiology in conjunction with concentration jump experiments was employed to define the mode of interaction of A9C with TMEM16A channels. Key Results In the presence of high intracellular Ca2+, A9C inhibited TMEM16A currents in a voltage‐dependent manner by entering the channel from the outside. A9C activation, revealed in the presence of submaximal intracellular Ca2+ concentrations, was also voltage‐dependent. The electric distance of A9C inhibiting and activating binding site was ~0.6 in each case. Inhibition occurred according to an open‐channel block mechanism. Activation was due to a dramatic leftward shift in the steady‐state activation curve and slowed deactivation kinetics. Extracellular A9C competed with extracellular Cl−, suggesting that A9C binds deep in the channel's pore to exert both inhibiting and activating effects. Conclusions and Implications A9C is an open TMEM16A channel blocker and gating modifier. These effects require A9C to bind to a region within the pore that is accessible from the extracellular side of the membrane. These data will aid the future drug design of compounds that selectively activate or inhibit TMEM16A channels. PMID:26562072

  4. Multi-Informant Assessment of Anxiety regarding Ano-Genital Examinations for Suspected Child Sexual Abuse (CSA)

    ERIC Educational Resources Information Center

    Scribano, Philip V.; Hornor, Gail; Rhoda, Dale; Curran, Sherry; Stevens, Jack

    2010-01-01

    Objective: Given the commonly held belief that physical examinations for child sexual abuse (CSA) are very distressing, our primary objective was to evaluate anxiety during these assessments using the Multidimensional Anxiety Score for Children (MASC-10). A second objective was to compare self-reported anxiety to parental report using the MASC-10…

  5. [Description of the follow-up protocol for idiopathic intracranial hypertension in the neuro-ophthalmological unit of a tertiary hospital].

    PubMed

    González-Hernández, Ayoze; Tandón-Cárdenes, Luis; Cabrera-Naranjo, Fernando; Guzmán-Fernández, María; Fabre-Pi, Óscar; López-Veloso, Carolina

    2013-05-16

    Objetivo. Revisar los resultados de la implantacion de un protocolo de seguimiento de pacientes con hipertension intracraneal idiopatica (HICI) en una unidad de neurooftalmologia (UNO). Pacientes y metodos. Se realizo una revision bibliografica para determinar las exploraciones necesarias que debian incluirse en el protocolo de seguimiento, asi como la frecuencia optima de las visitas y la duracion adecuada del seguimiento. Posteriormente, se revisaron de forma prospectiva los pacientes incluidos desde la creacion de la UNO y se compararon con los pacientes incluidos en el registro de HICI previo a la creacion de la UNO. Resultados. Desde la implantacion del protocolo, en el 100% de los pacientes se ha valorado la agudeza visual y la campimetria visual a los tres meses, a los seis meses y al ano del diagnostico. Ademas, en un 91%, 72,8% y 100% de los pacientes con HICI se realizo una campimetria visual a los tres meses, a los seis meses y al ano del diagnostico, respectivamente. Antes de la implantacion de nuestro protocolo de seguimiento, se habian realizado 190, lo que corresponde a unas tres por paciente. El numero de punciones lumbares realizadas desde la creacion de la UNO es de 11. Conclusiones. La creacion de una UNO multidisciplinar permite optimizar los recursos y mejorar la asistencia a los pacientes con HICI. Esto deberia redundar en una mejoria del pronostico funcional de estos pacientes.

  6. Quantifying Uncertainty in Early Lifecycle Cost Estimation for DOD Major Defense Acquisition Programs

    DTIC Science & Technology

    2012-10-31

    Acquisition Programs Cost Estimation Research Team: Bob Ferguson ( SEI - SEMA) Dennis Goldenson PhD ( SEI - SEMA) Jim McCurley ( SEI ...SEMA) Bob Stoddard ( SEI - SEMA) Dave Zubrow PhD ( SEI - SEMA) Julie Cohen ( SEI - ASP) Tim Morrow ( SEI - ASP) Eduardo Miranda PhD (CMU ISR...McCurley Senior Technical Staff Jim McCurley is a Senior Member of the Technical Staff at the Software Engineering Institute ( SEI ). During his 15

  7. The Universe in a Box: Introduction to the Study of Astronomy in the Initial Formation of Physics Teachers. (Spanish Title: El Universo Representado en Una Caja: Introducción al Estudio de la Astronomía en la Formación Inicial de Profesores de Física.) O Universo Representado em Uma Caixa: Introdução ao Estudo da Astronomia NA Formação Inicial de Professores de Física

    NASA Astrophysics Data System (ADS)

    Longhini, Marcos Daniel

    2009-07-01

    This is a report of an activity of introduction to the study of Astronomy developed with a group of future Physics teachers at a Brazilian public university. Such activity had the goal of giving privileged emphasis to notions of spatiality, alternative conceptions of the participants and the process of interaction among peers, and consisted of the representation, in a three dimensional space, of the models of the universe that the participants had. The results, which were categorized as miscellaneous, geocentric, heliocentric and acentric models of the universe, were qualitatively analyzed. Analyses of the activity in the perspective of the participants are indicated and additional considerations are made regarding its use as a resource for teaching Astronomy and for teacher training. Este es el informe de una actividad para presentar un estudio introductorio de la Astronomía, desarrollado con una clase de futuros profesores de física en una universidad pública brasileña. Esta actividad tuvo como objetivo centrar las nociones de espacialidad, las concepciones alternativas de los participantes y el proceso de interacción entre pares, y consistió en la representación en un espacio tridimensional, de los modelos del universo que los participantes habían. Los resultados, que se clasificaron en universo miscelania, geocéntrico, heliocéntrico y acentrico, se analizaron cualitativamente. Son identificadas análisis de la actividad por los participantes, e hizo observaciones sobre su uso como recurso para la enseñanza de la astronomía y la formación de docentes. Trata-se do relato de uma atividade de introdução ao estudo da Astronomia, desenvolvida com uma turma de futuros professores de Física, em uma universidade pública brasileira. Tal atividade teve como meta privilegiar noções de espacialidade, as concepções alternativas dos participantes e o processo de interação entre pares e constou da representação, em um espaço tridimensional, dos

  8. Recommendations from the AIA/SEI Workshop on Research Advances Required for Real-Time Software Systems in the 1990s Held in Pittsburgh, Pennsylvania on 13-14 September 1989

    DTIC Science & Technology

    1989-09-14

    MS WT-1 7 (513) 255-3947 Dallas, TX 75265-0003 (214) 266-7791 Walt Scacchi Assistant Professor Daniel P. Siewiorek University of Southern California...Pittsburgh, PA 15213-3890 scacchi @pollux.usc.edu (412) 268-2570 arpanet:dps@a.gp.cs.cmu.edu Lui Sha Senior Member of the Technical Staff David R. Smith

  9. [Burnout in Portuguese Healthcare Professionals: An Analysis at the National Level].

    PubMed

    Marôco, João; Marôco, Ana Lúcia; Leite, Ema; Bastos, Cristina; Vazão, Maria José; Campos, Juliana

    2016-01-01

    Introdução: O burnout é uma síndrome psicológica, caracterizada por elevada exaustão emocional, elevada despersonalização e baixa realização profissional, que conduz à erosão dos valores pessoais, profissionais e de saúde. Este estudo reporta a prevalência do burnout em profissionais de saúde Portugueses. Material e Métodos: Os níveis de burnout foram estimados pelo Maslach Burnout Inventory - Human Services Survey numa escala ordinal de zero (nunca) a seis (sempre) pontos. A amostra foi constituída por 1 262 enfermeiros e 466 médicos com médias de idade de 36,8 anos (DP = 12,2) e 38,7 (DP = 11,0), respetivamente. Os participantes foram provenientes de todos os distritos nacionais (35% Lisboa; 18% Porto; 6% Aveiro, 6% Setúbal, 5% Coimbra; 5% regiões autónomas), com atuação em meio hospitalar (54%), centros de saúde (Unidade de Saúde Familiar - 30%; Unidades de Cuidados de Saúde Primários - 8%) e outras instituições públicas/privadas (8%). Resultados: A análise dos níveis de burnout revelou que ambas as categorias profissionais apresentaram níveis moderados a elevados de burnout (M = 3,0; DP = 1,7) não sendo significativas as diferenças entre as duas profissões. Vila Real (M = 3,8; SD = 1,7) e a Madeira (M = 2,5; DP = 1,5) são as regiões onde os níveis de burnout são mais e menos elevados, respetivamente. Os níveisde burnout não diferiram significativamente entre Hospitais, Unidades de Cuidados de Saúde Personalizados e Unidades de Saúde Familiares. Os profissionais com maior tempo na função são menos acometidos por burnout (r = -0,15) não ocorrendo associação significativa com a duração da jornada de trabalho (r = 0,04). A má qualidade das condições de trabalho foi o melhor preditor do burnout (r = -0,35). Discussão: A ocorrência da síndrome de burnout em profissionais de saúde portugueses é frequente, estando associada à percepção de más condições de trabalho e à menor duração do tempo de servi

  10. On the Formation of a Study Group to the Realization of Workshops for Teachers: Astronomy in Basic Education in Umuarama-Pr (Spanish Title: De la Formación de un Grupo de Estudios a la Realización de los Talleres Para los Profesores: la Astronomía en la Educación Básica en Umuarama-Pr ) Da Formação de um Grupo de Estudos À Realização de Oficinas Para Professores: a Astronomia na Educação Básica em Umuarama-Pr

    NASA Astrophysics Data System (ADS)

    Belusso, Diane; Akira Sakai, Otávio

    2013-12-01

    In this article, we aimed to present the activities developed by the Astronomy Study Group (ASG) to contribute to the dissemination and improvement of the astronomy teaching-learning. The results of a research carried out in schools of Umuarama-PR are shown, with the intention of checking the students' knowledge and interest in relation to Astronomy. It is reported the realization of workshops for Science teachers linked to the Education Regional Nucleus. The research and the workshop execution promoted the direct contact of the study group with the community; the results were used to diagnose the state of astronomy teaching-learning, in the basic education in Umuarama-PR. En este artículo se intenta presentar las actividades desarrolladas por el Grupo de Estudios de Astronomía (GEA) y contribuir para la divulgación y mejoría de la enseñanza-aprendizaje de la Astronomía. Se presentan los resultados de una investigación realizada en las escuelas de Umuarama-PR, con la intención de determinar el grado de conocimiento y el interés de los estudiantes en relación a la astronomía. Se relata la realización de talleres de capacitación para los profesores de ciencias vinculados al Núcleo Regional del Educación. La ejecución de la investigación y de los talleres promovió el contacto directo del grupo de estudios con la comunidad; los resultados sirvieron de diagnóstico de la enseñanza aprendizaje de la astronomía en la educación básica en Umuarama-PR. Neste artigo, objetiva-se apresentar as atividades desenvolvidas pelo Grupo de Estudos de Astronomia (GEA) e contribuir para a divulgação e melhoria do ensino-aprendizagem de astronomia. São apresentados os resultados de uma pesquisa realizada nas escolas de Umuarama-PR, com o intuito de averiguar o conhecimento e o interesse dos estudantes em relação à astronomia. Relata-se a realização de oficinas de capacitação para professores de ciências vinculados ao Núcleo Regional de Educação. A

  11. Stigma and Attitudes towards Psychiatric Patients in Portuguese Medical Students.

    PubMed

    Telles-Correia, Diogo; Gama Marques, João; Gramaça, João; Sampaio, Daniel

    2015-01-01

    Introdução: Este estudo pretende avaliar o impacto da educação psiquiátrica nas atitudes em alunos de medicina face aos doentes mentais. Material e Métodos: Foi conduzido um inquérito em corte transversal na maior faculdade de medicina portuguesa. Os alunos preencheram um questionário que incluía informação sociodemográfica, antecedentes pessoais e familiares de doença psiquiátrica, bem como a Community Attitudes towards the Mentally Ill scale. Resultados: Em 2 178 estudantes, 398 responderam ao inquérito, representando 18,2% daquela faculdade de medicina. Houve uma significativa melhoria em todas as dimensões avaliadas pela Community Attitudes towards the Mentally Ill scale, ao longo dos anos do curso de medicina. Os valores mais elevados verificaram-se na subescala Restritividade (38,01), e os valores mais baixos na sub-escala Autoritarismo (36,13). A melhor diferença verificou-se para a sub-escala Autoritarismo (5º ano - 1º ano = 2,03), e a pior diferença verificou-se para a sub-escala Benevolência (5º ano - 1º ano = 0,39). Os melhores resultados foram encontrados no final do 3º ano. Discussão: Os resultados poderão dever-se ao módulo de luta contra o estigma, incluído na disciplina de 'Introdução à Saúde Mental'. Esse efeito positivo ter-se-á perdido no 4º e 5º anos, com uma degradação das atitudes.Conclusão: Este estudo salienta a import'ncia dos módulos de luta contra o estigma na melhoria das atitudes dos estudantes de medicina perante a saúde mental. Este tipo de acções pedagógicas preventivas com intuito anti-estigma, devem ser na melhor preparação possível de gerações Médicas futuras.

  12. Cost-effectiveness of screening for anal cancer using regular digital ano-rectal examinations in men who have sex with men living with HIV

    PubMed Central

    Ong, Jason J; Fairley, Christopher K; Carroll, Susan; Walker, Sandra; Chen, Marcus; Read, Tim; Grulich, Andrew; Bradshaw, Catriona; Kaldor, John; Clarke, Philip

    2016-01-01

    Introduction Anal cancer in men who have sex with men (MSM) living with HIV is an important issue but there are no consistent guidelines for how to screen for this cancer. In settings where screening with anal cytology is unavailable, regular anal examinations have been proposed in some guidelines but their cost-effectiveness is unknown. Methods Our objective was to estimate the cost-effectiveness of regular anal examinations to screen for anal cancer in HIV-positive MSM living in Australia using a probabilistic Markov model. Data sources were based on the medical literature and a clinical trial of HIV-positive MSM receiving an annual anal examination in Australia. The main outcome measures for calculating effectiveness were undiscounted and discounted (at 3%) lifetime costs, life years gained, quality-adjusted life years (QALY) gained and incremental cost-effectiveness ratio (ICER). Results Base-case analysis estimated the average cost of screening for and management of anal cancer ranged from $195 for no screening to $1,915 for lifetime annual screening of men aged ≥ 50. Screening of men aged ≥ 50 generated ICERs of $29,760 per QALY gained (for screening every four years), $32,222 (every three years) and $45,484 (every two years). Uncertainty for ICERs was mostly influenced by the cost (financially and decrease in quality of life) from a false-positive result, progression rate of anal cancer, specificity of the anal examination, the probability of detection outside a screening program and the discount rate. Conclusions Screening for anal cancer by incorporating regular anal examinations into routine HIV care for MSM aged ≥ 50 is most likely to be cost-effective by conventional standards. Given that anal pap smears are not widely available yet in many clinical settings, regular anal exams for MSM living with HIV to detect anal cancer earlier should be implemented. PMID:26942721

  13. Co-operativity among defect sites in AnO2+ and An4O9 (An = U, Np or Pu)

    SciTech Connect

    Andersson, Anders David; Lezama Pacheco, Juan; Uberuaga, Blas P; Conradson, Steven D

    2008-01-01

    Actinide dioxides derived from the AnO{sub 2} fluorite lattice are of high technological relevance due to their application in nuclear reactor fuels. Oxidation of AnO{sub 2} compounds emerges as a central theme in fuel fabrication, reactor operation, long-term storage forms for both spent fuels and surplus weapons materials, and environmental actinide migration. In this paper, we use density functional theory calculations to study the oxidation of uranium, neptunium and plutonium dioxides, AnO{sub 2} (An = U, Np or Pu), in O{sub 2} and O{sub 2}/H{sub 2}O environments. We pay particular attention to the formation of oxygen clusters (co-operativity) in AnO{sub 2+x} and how this phenomenon govern oxidation thermodynamics and the development of ordered An{sub 4}O{sub 9} compounds. The so-called split di-interstitial, which is composed of two nearest neighbor octahedral oxygen interstitials that are distorted in such a way that they dislocate one regular fluorite lattice oxygen ion to form a cluster of triangular geometry, is predicted to be the fundamental building block of the most stable cluster configurations. We also identify how the formation of oxygen defect clusters and the degree of oxidation in AnO{sub 2+x} are both governed by the characer of the An-5f to excess O-2p charger transfer, i.e. the charge transfer to the O-2p orbitals of the interstitial-like (+x) ions, and the ability of the excess O-2p orbitals to hybridize with regular fluorite lattice ions.

  14. Ministerio da Educacao e Cultura. Trinta Anos de Organizacao e Situacao Atual (Ministry of Education and Culture [Brazil]. Thirty Years Ago and Now). Volumes I and III.

    ERIC Educational Resources Information Center

    Porto, Norma Carneiro Monteiro

    The economic rather than the educational aspect of Brazil's Ministry of Education and Culture is presented in this historical summary. The study was done as part of Brazil's national program of educational reform. Brazil is currently re-evaluating its school system with the view of adopting a nationally-administered system similar to that in…

  15. 1990: Ano Internacional de la alfabetizacion: Acciones sugeridas para America Latina y el Caribe = 1990 International Literacy Year: Suggested Actions for Latin America and the Caribbean.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Michoacan (Mexico). Regional Office for Educ. in Latin America & Caribbean.

    This booklet discusses the needs for literacy education in Latin America and the Caribbean during International Literacy Year. Particular focus is on the objectives of International Literacy Year and suggested actions are provided in the four following areas: (1) operative strategies for the realization of the International Literacy Year,…

  16. Me escuchas? Como conversar con ninos de cuatro a doce anos (Are You Listening to Me? Communicating with Children from Four to Twelve Years Old).

    ERIC Educational Resources Information Center

    Delfos, Martine F.

    Although talking to children is a daily activity for almost everyone at some stage in one's life and an essential activity for professionals who work with children, there is little research on activity. This Spanish-language book describes communication with children between the ages of 4 and 12 years, focusing on open question-and-answer sessions…

  17. Sugerencias para la Evolucion del Desarrollo: 0-5 Anos (Stages for the Development of Discovery [Learning in] 0-5 Year-Olds).

    ERIC Educational Resources Information Center

    Organization of American States, Washington, DC.

    Some points that may serve as a foundation of experience and reference in the stimulation of mentally retarded children during the years of one through five are presented. Points of development are given for the following breakdowns of time: three months, six months, nine months, 12 months, 18 months, two years, three years, four years, and five…

  18. Guia para Padres Intervencion Temprana en Pennsylvania para Bebes desde el Nacimiento a los Tres Anos (A Parent Guide to Early Intervention in Pennsylvania for Infants and Toddlers).

    ERIC Educational Resources Information Center

    Parent Education Network, York, PA.

    This guide, in Spanish, is intended to help Pennsylvania parents of infants and toddlers with disabilities to understand their rights and assist in the design of an appropriate early intervention preschool educational program. An overview of special education laws focus on the Individuals with Disabilities Education Act, Parts B and C. The main…

  19. Literacy Learning Parties for 3-5 Year Olds. Activity Book = Fiestas de aprendizaje de alfabetismo para ninos de 3-5 anos. Libro de actividades.

    ERIC Educational Resources Information Center

    Daniels, Ellen R.

    Noting that family members are a child's first teachers and set the course for future success, this activity book of "literacy learning parties" presents 10 activities that can be used at home to practice the skills and ideas learned at parent literacy workshops. Presented in English and Spanish versions, the activity book discusses the importance…

  20. Indice Bibliografico Ciencias de la Educacion. Ano 1988. Volume II No. 1. (Bibliographic Index of the Education Sciences. 1988. Volume II No.1).

    ERIC Educational Resources Information Center

    Centro de Investigacion, Madrid (Spain). Servicio de Documentacion.

    Published quarterly, this annotated bibliography indexes articles from scholarly Spanish journals, as well as significant foreign journals, considered important in the field of education. References are organized alphabetically according to subject and within each subject by number, author, and content. A users' information description is provided…

  1. La investigacion sobre la calidad de los programas para ninos de hasta dos anos de edad (Research on Quality in Infant-Toddler Programs). ERIC Digest.

    ERIC Educational Resources Information Center

    Honig, Alice Sterling

    Concern about the quality of infant-toddler care programs has grown recently in response to two factors. The first is the need of employed parents for such care, and the second is research emphasizing the importance of brain development in the early years. This Spanish-language Digest introduces some of the many issues related to the quality of…

  2. "Cien Anos de Soledad" y el concepto de la "Caida Afortunada" ("One Hundred Years of Solitude" and the Concept of the "Fortunate Fall")

    ERIC Educational Resources Information Center

    Dario Carrillo, German; Stults, Barry

    1972-01-01

    Shows the influence of R.W.B. Lewis' work about the fall of Adam on the Marquez novel. Marquez' view coincides with Lewis' that Adam's fall should be considered not as a lapse from divine favor, but as an actual rise to the normal human level. (DS)

  3. La Educacion Especial para Ninos con Impedimentos Desde Recien Nacidos Hasta Cinco Anos de Edad = Special Education for Handicapped Children Birth to Five.

    ERIC Educational Resources Information Center

    New York State Education Dept. Albany. Office for the Education of Children with Handicapping Conditions.

    The manual, in Spanish, describes programs and resources available for preschool handicapped children and their families in conjunction with the New York State Education Department. Section 1 on assistance in securing services, reviews the service provided by Early Childhood Direction Centers, and outlines the role of local Committees on the…

  4. Guia para la ensenanza de la Lengua Nacional (segundo ano) (A Guide to the Teaching of the National Language (second year).

    ERIC Educational Resources Information Center

    Instituto Nacional de Pedagogia (Mexico).

    This document is an English-language abstract (approximately 1500 words) of a guide based on the results of experiments conducted by the Instituto Nacional de Pedagogia in its pilot school and other schools in Mexico, D. F. The foreword points out that there are two aspects of language teaching in elementary schools--the first year class to read…

  5. La Educacion en America Latina y El Caribe Durante Los Proximos 25 Anos. (Education in Latin America and the Caribbean during the Next 25 Years.)

    ERIC Educational Resources Information Center

    Roggi, Luis Osvaldo, Ed.

    1987-01-01

    The nine papers appearing in this document review both limitations and progress in education in Latin America, study the future of education in Latin America and the Caribbean, and make recommendations to the Regional Program for Educational Development (PREDE). There is, in addition, a lengthy transcription of a discussion, among eight of the…

  6. Molecular Confirmation of Anopheles (Anopheles) lesteri from the Republic of South Korea and its Genetic Identity with An. (Ano.) anthropophagus from China (Diptera: Culicidae)

    DTIC Science & Technology

    2003-12-08

    genus Anopheles (Beebe et al. 1999; Fritz 1998; Marinucci et al. 1999; Paskewitz et al. 1993; Wilkerson et al. In press). Morphological...Control Association, 16, 189- 198. Marinucci , M., Romi, R., Mancini, P., Di, L.M. & Severini, C. (1999) Phylogenetic relationships of seven

  7. Swath Bathymetry Surveys of the Monterey Bay Area from Point Ano Nuevo to Moss Landing, San Mateo, Santa Cruz, and Monterey Counties, California

    USGS Publications Warehouse

    Ritchie, Andrew C.; Finlayson, David P.; Logan, Joshua B.

    2010-01-01

    This report describes swath bathymetry and backscatter data acquired by the U.S. Geological Survey on the continental shelf within the Monterey Bay National Marine Sanctuary between Point A?o Nuevo and Moss Landing, in San Mateo, Santa Cruz, and Monterey Counties, Calif. The survey was done for the California Seafloor Mapping Program (CSMP), in field activities S-7-09-MB and S-10-09-MB, by the Western Coastal and Marine Geology (WCMG) Team of the U.S. Geological Survey (USGS). The data were aquired in two seperate surveys: (1) between August 13, 2009 and September 3, 2009, personnel from WCMG completed field activity S-7-09-MB, from Point A?o Nuevo south to Table Rock, as well as a block west of Soquel Canyon; (2) between October 12 and December 16, 2009, WCMG conducted field activity S-10-09-MB, surveying between Table Rock and Moss Landing.

  8. Considerations for Using Agile in DoD Acquisition

    DTIC Science & Technology

    2010-04-01

    Buettner, Aerospace Joe Tatem, Raytheon Stephany Bellomo, SEI Nanette Brown, SEI John Foreman, SEI Dr. John Goodenough, SEI Harry Levinson, SEI...event_details.php?id=452 [2] H. Glazer, J. Dalton, D. Anderson, M. Konrad , and S. Shrum, "CMMI or Agile: Why Not Embrace Both," Carnegie Mellon

  9. Barotrauma em peixes em usinas hidrelétricas: ferramentas para o estudo

    SciTech Connect

    Do Vale Beirao, Bernardo; Castelo Branco Marciano, Natlia; de Souza Dias, Luma; Carvalho Falco, Ricardo; Wander Dias, Edson; Leite Fabrino, Daniela; Barreira Martinez, Carlos; Martins Da Silva, Luiz Gustavo; Walker, Ricardo W.; Brown, Richard S.; Deng, Zhiqun

    2015-09-30

    The main source of electric power generation in Brazil comes from hydropower plants, nevertheless, the installed power is expected to raise 56.8%, reaching a total of 116,000 MW at the year 2020. The increase at the hydroelectric sector will be responsible for a series of fish community impacts. One of the impacts over the fish community is related to fish kills due to downstream passage through turbines or fish entrance at the draft tube from the tailrace. Usually when there is a maneuver and the turbine stops, fish get attracted and enter the draft tube and, just as the downstream passage through a turbine, when the turbine starts, a rapid decompression occurs and can cause barotrauma. When such events happen, according to Boyle’s law (P1V1=P2V2), swim bladder volume expands at the same rate that the pressure decreases, which can lead to the organ’s rupture.

  10. [Measuring Instruments of the Quality of Life Pediatric Palliative Care].

    PubMed

    Araújo, Joana; Dourado, Marília; Ferreira, Pedro Lopes

    2015-01-01

    Introdução: Os cuidados paliativos estão intimamente ligados ao conceito de qualidade de vida. Neste trabalho, focaremos a nossa atenção na necessidade de avaliar a qualidade de vida em cuidados paliativos pediátricos oncológicos.Objetivo: Descrever/comparar os instrumentos de medição da qualidade de vida em cuidados paliativos pediátricos oncológicos. Material e Métodos: Pesquisa da bibliográfica dos vários instrumentos de medição da qualidade de vida das crianças em cuidados paliativos, em inglês e português, entre 2000 e 2013, nas bases de dados reconhecidas para este efeito. Resultados: Encontraram-se quinze instrumentos de medição: 10 genéricos e cinco específicos. Identificou-se, para cada instrumento de medição, país de origem, faixa etária para que se encontra direcionado, modalidade de preenchimento, número de dimensões avaliadas, descrição das dimensões, número de perguntas, propriedades psicométricas e validação para português. Discussão: Verifica-se que tem havido uma crescente preocupação em medir a qualidade de vida em idade pediátrica e que a maioria dos instrumentos de medição foi desenhada, nos Estados Unidos, após 1994, coincidindo temporalmente com a definição de qualidade de vida da Organização Mundial de Saúde. Relativamente à faixa etária, a maioria dos instrumentos foi desenvolvida para crianças com idade igual ou superior a oito anos não existindo nenhum para ser respondido apenas pela criança. Podemos verificar que a maioria dos instrumentos de medição, sobretudo os mais atuais, procuram envolver a criança na avaliação da sua própria qualidadede vida relacionada com a saúde através do autopreenchimento (n = 10). Porém, há ainda uma dependência substancial dos pais para a medição da qualidade de vida relacionada com a saúde dos seus filhos, apesar dos estudos que demonstram diferenças na perceção de qualidade de vida relacionada com a saúde entre a criança e os pais

  11. [Atypical femoral fractures and bisphosphonates treatment: is it a risk factor?].

    PubMed

    Geada, Nuno; Mafra, Inês; Barroso, Rogério; Franco, José

    2014-01-01

    IntroduçÉo: Os bifosfonatos têm eficácia comprovada na prevençÉo das fracturas osteoporóticas. Contudo, têm sido descritas fracturas femorais atípicas associadas à toma prolongada de bifosfonatos com um padrÉo radiológico bem definido. Os objectivos no nosso estudo foram caracterizar os doentes de idade ≥ 65 anos com fracturas femorais (subtrocantéricas/diafisárias) consideradas típicas e atípicas e avaliar a relaçÉo entre a ocorrência das fracturas atípicas e o uso de bifosfonatos.Material e Métodos: Realizámos um estudo caso-controlo com os doentes admitidos no nosso Hospital por fractura subtrocantérica ou diafisária do fémur, num período de cinco anos e meio. Após aplicaçÉo dos critérios de exclusÉo, as 92 fracturas (91 doentes) foram classificadas como atípicas ou típicas. A determinaçÉo do tratamento prévio com bifosfonatos foi obtida através do historial clínico dos doentes.Resultados: Foram encontradas 11 fracturas atípicas (10 doentes) e 81 fracturas típicas (81 doentes). A idade mediana entre os dois grupos foi estatisticamente diferente (72 anos - atípicas vs 80 anos - típicas, p < 0,01). A razÉo do uso de bifosfonatos foi de 0,60 nas fracturas atípicas e de 0,01 nas típicas, traduzindo um odds ratio de 101,1 (p < 0,01).DiscussÉo: Na generalidade, os nossos resultados sÉo apoiados e estÉo de acordo com os estudos publicados referentes à ocorrência de fracturas femorais atípicas associadas à toma de bifosfonatos.ConclusÉo: Apesar do pequeno número de casos foi possível demonstrar a relaçÉo, estatisticamente, significativa entre as fracturas femorais atípicas e a toma de bifosfonatos. De notar que estas fracturas atípicas ocorreram em doentes, significativamente, mais jovens do que os doentes com fracturas típicas.

  12. [Epidemiology of Vertigo on Hospital Emergency].

    PubMed

    Roque Reis, Luis; Lameiras, Rita; Cavilhas, Pedro; Escada, Pedro

    2016-05-01

    Introdução: A vertigem é um dos motivos mais frequentes na procura de atendimento médico especializado na urgência. O objetivo deste estudo foi avaliar o peso real que as alterações do equilíbrio têm na urgência de Otorrinolaringologia, as suas características epidemiológicas e uma eventual sazonalidade por estações do ano. Usou-se uma amostra de doentes que utilizou o serviço de urgência desta especialidade de um hospital central universitário de Lisboa durante um período de quatro anos. Material e Métodos: O projeto foi concebido como um estudo epidemiológico descritivo de tipo populacional, retrospectivo, no período de 2010 a 2013. Incluiu uma população total de 40 173 atendimentos de doentes que nesse período utilizou o serviço de urgência de Otorrinolaringologia. As variáveis estudadas incluíram a idade, género, número anual de casos (total e percentual), data da crise de vertigem, distribuição sazonal por estações do ano e proporção anual de casos internados. Resultados: Um total de 4 347 doentes (10,8%) procurou atendimento médico devido a vertigem ou alterações do equilíbrio ao longo dos quatro anos do estudo. Verificou-se um aumento anual do número de casos entre 7,6% (em 2010) a 17% (em 2013). As mulheres foram mais frequentemente afetadas (68,3%) e as crises ocorreram mais frequentemente em indivíduos entre os 60 e 79 anos de idade (40%). Os casos distribuíram-se de forma heterogénea entre as estações do ano, havendo mais episódios de vertigem no verão e no outono e com uma tendência crescente entre 2010 e 2013. O número de internamentos aumentou anualmente nesse período. Discussão: A epidemiologia da vertigem e dos distúrbios vestibulares específicos é ainda um campo a estudar, pois pode ter utilidade para a tomada de decisões clínicas e para o planeamento dos cuidados de saúde. Conclusão: O estudo revelou que os casos de vertigem na urgência aumentaram anualmente e são mais frequentes no sexo

  13. Tendências de teses e dissertações sobre ensino de astronomia no Brasil

    NASA Astrophysics Data System (ADS)

    Bretones, P. S.; Megid Neto, J.

    2003-08-01

    Neste trabalho são apresentados os resultados de uma pesquisa do tipo estado da arte sobre teses e dissertações defendidas no Brasil e relativas ao ensino de Astronomia. Teve por objetivo identificar essa produção e conhecer as principais tendências da pesquisa nesse campo. O procedimento inicial consistiu de um levantamento bibliográfico junto ao Centro de Documentação em Ensino de Ciências (CEDOC) da Faculdade de Educação da UNICAMP e ao Banco de Teses da CAPES disponível na Internet. Foram localizadas 13 dissertações de mestrado e 3 teses de doutorado, as quais foram estudadas em função dos seguintes aspectos: instituição, ano de defesa, nível escolar abrangido no estudo, foco temático do estudo e gênero de trabalho acadêmico. Deste conjunto de pesquisas, 13 (81,3%) delas foram defendidas a partir da segunda metade dos anos 90, indicando uma preocupação mais recente com temas relativos ao ensino de Astronomia no conjunto da produção acadêmica em programas de pós-graduação no Brasil. Verificou-se que 43,7% dos trabalhos foram produzidas na USP e 18,8% na UNICAMP. Quanto ao nível escolar abrangido nos estudos, predominaram os estudos direcionados ao Ensino Fundamental de 5a a 8a séries (62,5%). No que diz respeito ao foco temático das pesquisas, as principais tendências voltaram-se: 56,3% para Conteúdo e Método; 43,8% para Concepções do Professor; 37,5% para Currículo e Programas; 37,5% para Recursos Didáticos. Quanto ao gênero de trabalho acadêmico, verificou-se que 43,8% são de Pesquisa Experimental e 31,3% de Pesquisa de Análise de Conteúdo. Estudos de revisão bibliográfica como este visam colaborar com a divulgação ampla da produção acadêmica em determinada área, traçando algumas de suas tendências. Ao mesmo tempo possibilita, a partir de investigações decorrentes, apontar as suas contribuições para o ensino e sinalizar com necessidades a serem supridas por futuras pesquisas.

  14. Tendências De Teses e Dissertações Sobre Educação em Astronomia No Brasil

    NASA Astrophysics Data System (ADS)

    Bretones, Paulo Sergio; Megid Neto, Jorge

    2005-07-01

    Apresentam-se os resultados de uma pesquisa do tipo estado da arte sobre teses e dissertações defendidas no Brasil e relativas ao ensino de Astronomia, com objetivo de identificar essa produção e conhecer as principais tendências da pesquisa nesse campo. Foram localizadas 13 dissertações de mestrado e 3 teses de doutorado, as quais foram estudadas em função dos seguintes aspectos: isntituição, ano de defesa, nível escolar abrangido no estudo, foco temático do estudo e gênero de trabalho acadêmico. Pretende-se assim colaborar com a divulgação ampla da produção acadêmica na área. Ao mesmo tempo o estudo possibilita, a partir de investigações decorrentes, apontar as contribuições dessa produção para o ensino e sinalizar com necessidades a serem supridas por futuras pesquisas.

  15. A correlação índice espectral vs. luminosidade em QSOs e suas implicações

    NASA Astrophysics Data System (ADS)

    Garcia-Rissmann, A.

    2003-08-01

    Estudos de variabilidade de núcleos ativos já demonstraram ser comum o fato de seu contínuo óptico/UV tornar-se mais "duro" à medida que a luminosidade aumenta. Essa tendência ocorre tanto de forma individual quanto global, e pode ter implicações importantes (1) para estudos fotométricos de variabilidade conduzidos numa banda fixa no referencial do observador, comparando objetos a diferentes redshifts, e (2) no cálculo da correção K, com consequente impacto na determinação de massas de buracos negros e bojos de galáxias hospedeiras (através da relação de Magorrian). Confirmo aqui as correlações positivas entre o índice espectral e a luminosidade óptica, utilizando dados espectroscópicos de 11 QSOs monitorados no Brasil e no Chile, durante ~2 anos. O estudo é complementado com parâmetros extraídos de espectros e de dados fotométricos públicos de quasares. Destaco ainda as diferenças observadas em tais correlações para objetos do tipo radio-loud e radio-quiet. Este projeto é financiado pelo I. Milênio/CNPq.

  16. Quantifying Uncertainty for Early Life Cycle Cost Estimates

    DTIC Science & Technology

    2013-04-01

    NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Carnegie Mellon University,Software Engineering Institute ( SEI ),Pittsburgh,PA,15213 8...the technical staff at the Software Engineering Institute ( SEI ). During his 15 years at the SEI , his areas of expertise have included data analysis...sei.cmu.edu] Robert Ferguson—Ferguson is a senior member of the technical staff at the Software Engineering Institute ( SEI ). He works primarily on

  17. Competency Lifecycle Roadmap: Toward Performance Readiness

    DTIC Science & Technology

    2012-09-01

    CMU/ SEI -2012-TN-020 CERT® Program http://www.sei.cmu.edu SEI markings v3.2 / 30 August 2011 Copyright 2012 Carnegie Mellon University. This...report was prepared for the SEI Administrative Agent AFLCMC/PZE 20 Schilling Circle, Building 1305, 3rd Floor Hanscom AFB, MA 01731-2125 NO WARRANTY...Mellon University. * These restrictions do not apply to U.S. government entities. CMU/ SEI -2012-TN-020 | i Table of Contents Abstract vii 1

  18. [Skin cancer in kidney transplant recipients: incidence and association with clinical and demographic factors].

    PubMed

    Borges-Costa, João; Vasconcelos, João Pedro; Travassos, Ana Rita; Guerra, José; Santana, Alice; Weigert, André; Sacramento Marques, Manuel

    2013-01-01

    Introdução/Objetivos: Os doentes transplantados têm maior risco de cancro cutâneo não melanoma, sobretudo basaliomas e carcinomas espinocelulares. Os objetivos do estudo foram determinar a incidência destas neoplasias numa série de doentes com transplante renal e pesquisar associações destas com variáveis clínicas e demográficas. Material e Métodos: Estudo prospetivo com observação dermatológica e entrevista a 127 doentes com transplante renal observados pela primeira vez no entre Julho de 2010 e Dezembro de 2011. Todos os tumores cutâneos diagnosticados tiveram confirmação histológica. Os testes utilizados foram os testes não paramétricos de Mann-Whitney, teste do Qui-quadrado e teste exato de Fisher, com um nível de significância de 5%. Resultados: A média de idades foi 53 anos (s = 12,98) e 67% (85 / 127) dos doentes eram do sexo masculino. A média de anos decorridos desde o transplante foi oito anos (s = 4,61) e no exame objetivo diagnosticou-se cancro cutâneo não melanoma em 16% (20 / 127) dos doentes, com igual número de basaliomas e carcinomas espinocelulares. Nas áreas fotoexpostas observaram-se queratoses actínicas e verrugas virais em, respetivamente, 24% (30 / 127) e 8% (10 / 127) dos doentes. O cancro cutâneo não melanoma diagnosticado no nosso estudo esteve significativamente associado a maior idade (p = 0,016), maior duração do período sob imunossupressão (p = 0,003), atividade laboral no passado ao ar livre (p = 0,049) e com queratoses actínicas nas áreas fotoexpostas (p < 0,001). O único fármaco associado a estes tumores nesta série foi a medicação atual com azatioprina (p = 0,035 no teste exato de Fischer). Conclusões: A incidência de cancro cutâneo é elevada na nossa série e estes doentes beneficiariam de educação sobre medidas de fotoproteção e seguimento dermatológico regular. Este seguimento aumenta a adesão dos doentes a essas medidas e permite reduzir a incidência destes tumores cut

  19. [Adulthood Langerhans cell histiocytosis: experience of two Portuguese hospitals].

    PubMed

    de Brito, Margarida Dantas; Martins, Éngelo; Andrade, Joaquim; Guimarães, José; Mariz, José

    2014-01-01

    IntroduçÉo: A histiocitose de células de Langerhans é uma doença heterogénea e mais frequente em crianças. Entre 1/2001 e 12/2013 admitimos 20 doentes com HCL nas duas instituições. O objectivo deste trabalho foi caracterizar esta populaçÉo, avaliando as formas de apresentaçÉo, o estadiamento e tratamento.Material e Métodos: Estudo retrospectivo; consulta do processo clínico.Resultados: Dos 16 doentes analisáveis verificamos uma mediana de idade 34 anos (15-48), 10 mulheres e 6 homens. Os motivos que determinaram a referenciaçÉo dos doentes foram: queixas respiratórias em 37,5%; alterações ósseas em 37,5%; queixas dentárias em 25%; sintomas constitucionais em 19%; lesões mucocut'neas em 6% e outro foi um achado histológico inesperado após tiroidectomia. O diagnóstico histológico foi obtido em: osso em 50%; pulmÉo em 37,5%; fígado, mucosa vulvar e peça de tiroidectomia em 6%, respectivamente. O estadiamento assumido na prática clínica foi: envolvimento de órgÉo único (uni/multifocal) em 69% e doença multissistémica em 31%. A mediana de seguimento foi cinco anos (dois meses-11 anos) e a sobrevivência global 92%. Actualmente: 19% estÉo vivos sem doença; 44% estÉo vivos com doença; 25% estÉo em tratamento e 12% morreram.DiscussÉo: Estes resultados estÉo de acordo com a literatura. No entanto, segundo as recomendações actuais consideramos que 56% doentes efectuaram estudo complementar incompleto condicionando subestadiamento e provavelmente subtratamento. Verifica-se heterogeneidade de procedimentos no estadiamento e tratamento.ConclusÉo: Frequentemente há dificuldades e atraso no diagnóstico desta entidade clínica. SÉo importantes estudos prospectivos internacionais na populaçÉo adulta.

  20. Como ayudar a su hijo a tener exito en la escuela, con actividades para ninos entre las edades de 5 a 11 anos (Helping Your Child Succeed in School, with Activities for Children Ages 5 through 11).

    ERIC Educational Resources Information Center

    Paulu, Nancy

    At the heart of the No Child Left Behind Act of 2001 is a promise to raise standards for all children and to help all children meet those standards. This Spanish-language booklet provides information that parents can use to help their child succeed in school. Following an introduction, the second section of the booklet, "The Basics," offers…

  1. Como ayudar a su hijo durante la edad preescolar, con actividades para los ninos desde el nacimiento hasta los 5 anos (Helping Your Preschool Child, with Activities for Children from Infancy through Age 5).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC. Office of Intergovernmental and Interagency Affairs.

    The first 5 yeas of a child's life are a time of tremendous physical, emotional, social, and cognitive growth. Noting that research shows that children are more likely to succeed in learning when their families actively support them, this Spanish-language booklet is intended for families and caregivers who want to help their preschool children…

  2. Effect of Spin-Orbit Coupling on the Actinide Dioxides AnO2 (An=Th, Pa, U, Np, Pu, and Am): A Screened Hybrid Density Functional Study

    SciTech Connect

    Wen, Xiaodong; Martin, Richard L.; Roy, Lindsay E.; Scuseria, Gustavo E.; Rudin, Sven P.; Batista, Enrique R.; McCleskey, Thomas M.; Scott, Brian L.; Bauer, Eve; Joyce, John J.; Durakiewicz, Tomasz

    2012-10-21

    We present a systematic comparison of the lattice structures, electronic density of states, and band gaps of actinide dioxides, AnO₂ (An=Th, Pa, U, Np, Pu, and Am) predicted by the Heyd-Scuseria-Ernzerhof screened hybrid density functional (HSE) with the self-consistent inclusion of spin-orbit coupling(SOC). The computed HSE lattice constants and band gaps of AnO₂ are in consistently good agreement with the available experimental data across the series, and differ little from earlier HSE results without SOC. ThO₂ is a simple band insulator (f⁰), while PaO₂, UO₂, and NpO₂ are predicted to be Mott insulators. The remainders (PuO₂ and AmO₂) show considerable O2p/An5f mixing and are classified as charge-transfer insulators. We also compare our results for UO₂, NpO₂, and PuO₂with the PBE+U, self interaction correction (SIC), and dynamic mean-field theory (DMFT) many-body approximations.

  3. What to Teach Your Child: A Handbook for Parents of 4-6 Year Olds. (Lo Que Pueden Ensenarles a Los Ninos: Un Manual Para Padres De Ninos De 4 A 6 Anos).

    ERIC Educational Resources Information Center

    Wile, Elizabeth M.

    Prepared specifically for parents of children ages 4 to 6, this brief guide (available in English or Spanish) provides basic information about what basic skills children should master, and how parents can help them acquire these skills. Ideas and suggestions are given for teaching such basic skills as controlling large and small muscles,…

  4. Como ayudar a su hijo a ser un buen lector: Con actividades para los ninos desde el nacimiento hasta los 6 anos (Helping Your Child Become a Reader: With Activities for Children from Infancy through Age 6).

    ERIC Educational Resources Information Center

    Lehr, Fran; Osborn, Jean

    When parents and other family members read with their children, help them with homework, talk with their teachers, and participate in school or other learning activities, they give their children a tremendous advantage. The foundation for learning to read is in place long before children enter school and begin formal reading instruction. Families…

  5. International Symposium on Visually Handicapped Infants and Young Children: Birth to Seven (2nd, Aruba, 1987). "The First Steps." Proceedings = Simpasio Internacional sobre Ninos Visualmente Deficientes de Nacimiento hasta Siete Anos (2nd, Aruba, 1987). "Los Primeros Pasos."

    ERIC Educational Resources Information Center

    Palmer, Lillian, Ed.; And Others

    This symposium focused on the special needs of visually handicapped infants and young children. Texts of 48 papers are presented, including keynote addresses by W. Aubrey Webson ("The First Steps") and Heather Hewitt ("First Steps--Parenting, Prevention and Programming"). Regional reports are provided for Japan, Bangladesh, the…

  6. Little Steps for New Parents: A Week-by-Week Guide and Journal for Baby's First Year = Pasitos para nuevos padres: Una guia y diario semanal para el primer ano del bebe.

    ERIC Educational Resources Information Center

    Briggs, Sandy

    Providing young infants with a loving and interesting environment through play will have a positive impact on their future. This book, designed for first time parents, provides simple and enjoyable activities intended to promote brain development during the first year. The book's introduction discusses the importance of the environment during the…

  7. National Migrant Education Program: Early Childhood Development Skills--Birth Through 5 Years (Desarrollo de Destrezas en la Temprana Infancia--Desde el Nacimiento Hasta los Cinco Anos de Edad).

    ERIC Educational Resources Information Center

    1979

    Compiled to ensure cooperation between states and to provide continuity of reporting on developmental skills for the migrant child from birth through five years of age, this booklet lists the psychomotor, cognitive, and affective skills which are reported through the Migrant Student Record Transfer System (MSRTS). Published in both English and…

  8. Revista de Documentacao de Estudos em Linguistica Teorica e Aplicada (DELTA): Novos Estudos em Gamatica Gerativa, 2001 (Journal of Documentary Studies in Theoretical and Applied Linguistics [DELTA]: New Studies in Generative Grammar, 2001).

    ERIC Educational Resources Information Center

    Barbara, Leila, Ed.; Rajagopalan, Kanavillil, Ed.

    2001-01-01

    These two issues of volume 17, include the following articles: "The Competing Motivation Model in the Functional Domains of Negation" (M. Angelica Furtado da Cunha); "Discursive Resonance and Politeness in Reading and Writing Practices" (Silvana Serrani Infante); "The Acquisition of Relative Clauses in Brazilian…

  9. Revista de Documentacao de Estudos em Linguistica Teorica e Aplicada (DELTA): Novos Estudos em Gamatica Gerativa (Journal of Documentary Studies in Theoretical and Applied Linguistics [DELTA]: New Studies in Generative Grammar).

    ERIC Educational Resources Information Center

    Revista de Documentacao de Estudos em Linguistica Teorica e Aplicada, 2000

    2000-01-01

    This issue contains the following articles: "Resumption and Last Resort" (Joseph Aoun); "Existentials, A-Chains, and Reconstruction" (Norbert Hornstein); "How Long Was the Nineteenth Century" (David Lightfoot); "Formal Features and Parameter Setting: A View From Portuguese Past Participles and Romance Future…

  10. Estudo de soluções locais e cosmológicas em teorias do tipo tensor-escalar

    NASA Astrophysics Data System (ADS)

    Silva E Costa, S.

    2003-08-01

    Teorias do tipo tensor-escalar são a mais simples extensão possí vel da Relatividade Geral. Nessas teorias, cujo modelo padrão é a teoria de Brans-Dicke, a curvatura do espaço-tempo, descrita por componentes tensoriais, aparece acoplada a um campo escalar que, de certo modo, representa uma variação na constante de acoplamento da gravitação. Tais teorias apresentam soluções locais e cosmológicas que, em determinados limites, recaem nas apresentadas pela Relatividade Geral, mas que em outros limites trazem novidades, tais como conseqüências observacionais da evolução de flutuações primordiais distintas daquelas previstas pela Relatividade Geral (ver, por ex., Nagata et al., PRD 66, p. 103510 (2002)). Graças a esta possibilidade de trazer à luz novidades em relação à gravitação, teorias do tipo tensor-escalar podem ser vistas como um interessante campo alternativo de pesquisas para soluções dos problemas de massa faltante (ou escura) e/ou energia escura. Seguindo tal linha, este trabalho, ainda em sua fase inicial, apresenta soluções gerais de teorias do tipo tensor-escalar para diversas situações, verificando-se em que consiste a divergência dessas soluções dos casos tradicionais possí veis na Relatividade Geral. Como exemplos das soluções aqui apresentadas pode-se destacar uma expressão geral para diferentes soluções cosmológicas englobando diferentes tipos de matéria (representados por diferentes equações de estado), e a expressão para uma solução local representando um buraco negro com rotação, similar à solução de Kerr da Relatividade Geral. Por fim, é importante ressaltar que, embora aqui apresentem-se poucos resultados novos, na literatura sobre o assunto a maior parte das soluções apresentadas limita-se a uns poucos casos especí ficos, tal como soluções cosmológicas apenas com curvatura nula, e que mesmo as soluções disponí veis são, em geral, pouco divulgadas e, portanto, pouco conhecidas, e é tal situação que este trabalho busca, em parte, reverter.

  11. Causes of Death in an Acute Psychiatric Inpatient Unit of a Portuguese General Hospital.

    PubMed

    Barbosa, Sofia; Sequeira, Márcia; Castro, Sara; Manso, Rita; Klut Câmara, Catarina; Trancas, Bruno; Borja-Santos, Nuno; Maia, Teresa

    2016-08-01

    Introdução: Os doentes afectos de patologia psiquiátrica apresentam maior risco de morte, tanto por causas naturais como não naturais. Este estudo avalia as causas de morte de todos os doentes de uma unidade de internamento de agudos de Psiquiatria num hospital geral em Portugal, ao longo de dezasseis anos (de 1998 a 2013). Material e Métodos: Vinte e um doentes morreram na unidade de internamento de doentes agudos entre 1998 e 2013 (média 1,3 por ano). As características demográficas, os diagnósticos médicos e psiquiátricos foram recolhidos através de um estudo retrospectivo que consistiu na análise dos processos clínicos da amostra selecionada. Os doentes transferidos para outras enfermarias durante o internamento não foram incluídos no estudo. Resultados: As doenças do sistema circulatório foram as causas de morte mais prevalentes, ocorrendo em 2/3 dos doentes, incluindo embolismo pulmonar (n = 6), acidente vascular cerebral (n = 3), arritmia cardíaca (n = 2), enfarte agudo do miocárdio (n = 1), rutura de aneurisma da aorta abdominal (n = 1) e insuficiência cardíaca (n = 1). Dois doentes morreram de pneumonia e em quatro casos a causa de morte foi indeterminada. Apenas um caso de suicídio foi registado. Discussão: As doenças do aparelho circulatório foram as causas de morte mais frequentes nesta unidade de agudos. O suicídio em doentes internados, apesar de constituir um evento raro, é uma realidade que comporta consequências complexas para os profissionais de saúde, familiares e restantes doentes, devendo permanecer como foco de prevenção continuada. Conclusão: Os estudos de mortalidade são importantes para determinar a qualidade dos cuidados de saúde e criar recomendações para medidas preventivas.

  12. [Relationship between smoking and anxiety and depression in primary care].

    PubMed

    Farinha, Helder; Raposo de Almeida, Joana; Aleixo, Ana Rita; Oliveira, Hugo; Xavier, Filomena; Santos, Ana Isabel

    2013-01-01

    Introdução: A prevalência de tabagismo em Portugal é estimada em 19,7% (2005). O tabagismo é prevalente nas perturbações da ansiedade. Alguns estudos referem que 60% dos fumadores tem história de depressão. A dependência tabágica pode ser avaliada pela escala de Fagerström. A Escala de Ansiedade e Depressão Hospitalar permite estimar a ansiedade e depressão. O objectivo deste trabalho foi procurar a existência de relação entre tabagismo e ansiedade/depressão em utentes de oito unidades de cuidados primários.Material e Métodos: Foi desenhado um estudo observacional, descritivo, transversal, analítico. Inquérito anónimo. Foram considerados como critérios de inclusão os utilizadores das unidades, maiores de 18 anos e alfabetizados e de exclusão os menores de 18 anos ou erros no preenchimento dos inquéritos. As variáveis consideradas foram: Fagerström, Escala de Ansiedade e Depressão Hospitalar, idade, estado civil, género, profissão, escolaridade.Resultados: Foram considerados no estudo um total de 608 indivíduos, sendo 64% do género feminino e 21% de fumadores. Não verificámos diferenças em termos de ansiedade ou depressão na comparação entre não fumadores, ex-fumadores e fumadores. Verificámos que o grau de dependência da nicotina varia directamente com a ansiedade e depressão embora só se encontre relação estatisticamente significativa no género feminino, mesmo após correcção do efeito da idade.Discussão: Existe relação entre dependência da nicotina e gravidade de sintomas de ansiedade e depressão, sobretudo no género feminino. Limitação: viés de selecção.Conclusão: Este estudo fornece informação relativa aos factores psicológicos associados ao consumo de tabaco, podendo ser útil no tratamento da dependência de nicotina.

  13. Synthesis, NMR characterisation and X-ray structures of mixed chalcogenido PNP ligands containing tellurium: crystal structures of SeiPr2PNP(H)iPr2 and [NaN(EPiPr2)2]infinity (E = Se, Te).

    PubMed

    Robertson, Stuart D; Chivers, Tristram

    2008-04-07

    Reaction of HN(PiPr2)2 with one equivalent of selenium in hexane at room temperature yields the monoselenide as the P-H tautomer Se=PiPr2-N=P(H)iPr2 (2b). Deprotonation of 2b with n butyllithium in the presence of TMEDA at -78 degrees C followed by addition of tellurium produces the air-sensitive, mixed chalcogenido complex [(TMEDA)Li(SePiPr2)(TePiPr2)N] (8Li) in >97% purity after recrystallisation. Similarly, deprotonation of Te=PiPr2-N=P(H)iPr2 (2c), followed by addition of sulfur, gives the sulfur analogue [(TMEDA)Li(SPiPr2)(TePiPr2)N] (7Li) in >99% purity. The symmetrical complexes [(TMEDA)Li(SePiPr2)2N] (4Li) and [(TMEDA)Li(TePiPr2)2N] (5Li) are produced by similar methods. Compounds 2b, 4Li, 5Li, 7Li and 8Li were characterised in solution by multinuclear (1H, 31P, 77Se and 125Te) NMR spectroscopy and their solid-state structures were determined by X-ray crystallography. The X-ray crystal structures of the polymeric chains [NaN(EPiPr2)2]infinity (4Na, E = Se and 5Na, E = Te) are also reported.

  14. [Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: genotype-phenotype correlation].

    PubMed

    Mendes, Catarina; Vaz Matos, Inês; Ribeiro, Luís; Oliveira, Maria João; Cardoso, Helena; Borges, Teresa

    2015-01-01

    Introdução: A hiperplasia congénita da suprarrenal por deficiência de 21-hidroxílase constitui uma das doenças hereditárias mais comuns. Resulta de diferentes mutações no gene CYP21A2 e, na maioria dos casos, a gravidade da doença correlaciona-se com a variação alélica do CYP21A2. O objetivo deste estudo foi descrever o espectro mutacional do CYP21A2 e avaliar a correlação genótipo-fenótipo numa coorte de doentes portugueses com deficiência de 21-hidroxílase. Material e Métodos: Estudo retrospetivo de 22 doentes com diagnóstico clínico de deficiência de 21-hidroxílase. Foi feita análise molecular do CYP21A2 e estabelecida a correlação genótipo-fenótipo. Resultados: Foi realizada genotipagem em 22 doentes não relacionados: 5 com a forma clássica perdedora de sal (idade média ao diagnóstico de 10,2 dias; mínimo 1, máximo 20 dias), 7 com a forma clássica virilizante simples (idade média ao diagnóstico de 3,5 anos; mínimo 0 dias, máximo 7 anos) e 10 com a forma não clássica (idade média ao diagnóstico de 5,7 anos; mínimo 4 anos, máximo 8 anos). Os defeitos genéticos mais frequentes nas formas clássicas foram o I2 splice (24%) e I172N (24%), seguindo-se o Q318X (16%) e deleções de genes (16%) e, na forma não clássica, o V281L (80%). Verificou-se uma concordância genótipo-fenótipo global de 81,8%. O genótipo permitiu prever adequadamente o fenótipo em 83,3%, 100% e 90% dos doentes com mutações compatíveis com a forma clássica perdedora de sal, clássica virilizante simples e não clássica, respectivamente. Discussão: A frequência de defeitos genéticos observados nos nossos doentes é comparável a estudos semelhantes. Observou-se, na maioria dos casos, uma boa correlação genótipo-fenótipo. Conclusões: A análise molecular do CYP21A2 fornece informação importante relativamente à gravidade da doença e no aconselhamento genético e pré-natal.

  15. Oncology Referral Concerning Paediatric Neurosurgery? Analysis of the Situation between 2008-2013 in the North of Portugal.

    PubMed

    Batista, Ana; Nogueira-Silva, Luís; Vaz, Rui; Oliveira, Joana

    2016-01-01

    Introdução: Os tumores primários do sistema nervoso central representam o segundo grupo de neoplasias mais frequente e são a principal causa de morte devido a tumores sólidos em crianças. O nosso estudo teve como objetivos realizar a mais atualizada análise epidemiológica desta doença no norte de Portugal e avaliar o possível benefício da centralização de cuidados. Material e Métodos: Este estudo de base populacional incluiu todos os tumores primários do sistema nervoso central diagnosticados e histologicamente confirmados em indivíduos menores de 18 anos de idade, que residem no norte do país, desde Janeiro 2008 até Dezembro 2013. Os dados foram obtidos por meio da avaliação dos processos clínicos dos doentes. Nós descrevemos as características das crianças e dos seus tumores e analisámos os quocientes doente: neurocirurgião pediátrico e tipo histológico de tumor: neurocirurgião pediátrico e as taxas de sobrevivência, mortalidade, complicações e recidiva. Resultados: Foram registados 147 casos. A média de idade ao diagnóstico foi de 8,0 ± 5,2 anos. Os astrocitomas foram o tipo histológico mais frequentemente encontrado (34%). O tipo histológico foi a única variável com influência estatisticamente significativa na mortalidade (p = 0,001). As sobrevivências a um, três e cinco anos relativas ao período entre 2008 - 2013 foram estatisticamente superiores às do intervalo entre 2005 - 2007. Os astrocitomas apresentam a mais alta taxa de sobrevivência, sendo estatisticamente diferente dos outros tipos de tumor (p = 0,015). Estimámos uma média de 12,25 casos tratados anualmente por neurocirurgião pediátrico no nosso hospital. Discussão: Os nossos resultados são, globalmente, consistentes com os encontrados na literatura mundial, mas registrámos taxas de sobrevivência mais altas. O número de casos tratados por neurocirurgião pediátrico está de acordo com o recomendado. Conclusão: Demonstrámos que houve melhoria

  16. [Uterine Carcinosarcoma: Clinicopathological Features and Prognostic Factors].

    PubMed

    Luz, Rita; Ferreira, Joana; Rocha, Mara; Jorge, Ana Francisca; Félix, Ana

    2016-10-01

    Introdução: O carcinossarcoma uterino é uma neoplasia bifásica rara e agressiva e está atualmente incluído no grupo de carcinoma do endométrio de alto risco. Os objetivos deste estudo foram determinar o perfil clinico-patológico, tratamento, padrões de recidiva/progressão, sobrevivência e fatores de prognóstico. Material e Métodos: Estudo retrospetivo de 42 doentes, estadiadas cirurgicamente e vigiadas num centro oncológico, entre 2005 e 2013. Os dados clínicos foram consultados nos processos e as características histopatológicas foram revistas para este estudo.Resultados: A idade mediana das doentes foi de 72 anos (61 - 81) e a maioria apresentava co-morbilidades. A distribuição por estádio foi a seguinte: 13 (31,0%) estádio I; oito (19,0%) estádio II; nove (21,4%) estádio III; e 12 (28,6%) estádio IV. A quimioterapia adjuvante foi instituída em 12 doentes e 21 realizaram radioterapia. A doença progrediu em 16 doentes e recidivou em nove após um intervalo curto. A sobrevivência global mediana foi de 18 meses (6,8 - 40) e a sobrevivência livre de doença mediana de 6 meses (0 - 22,8). O único fator prognóstico independente associado a pior sobrevivência foi a invasão da serosa (p = 0,02; HR ajustado 4,22; IC 95% 1,29 - 13,79). Discussão: Em concordância com outros estudos, o diagnóstico de carcinossarcoma uterino é frequentemente realizado com doença avançada e apresenta elevada taxa de progressão/recidiva. A variável que tem sido consistentemente identificada como principal fator de prognóstico é o estádio inicial, mas neste estudo o único fator independente foi a invasão da serosa. Conclusão: O presente estudo representa a maior série de carcinossarcoma uterino estudada em Portugal e reflete o quadro clínico,características histopatológicas e estádio no momento do diagnóstico e confirma a agressividade deste raro tumor.

  17. [Pediatric anesthetic during brain immaturity and neurodevelopment disorders].

    PubMed

    Catré, Dora; Lopes, Maria Francelina; Cabrita, António Silvério; Silva Viana, Joaquim

    2014-01-01

    Introdução: Diversos estudos experimentais e clínicos sugerem que fármacos usados em anestesia pediátrica podem exercer efeitos indesejáveis sobre o sistema nervoso central imaturo. O objetivo desta revisão consistiu em avaliar os resultados e conclusões de estudos publicados na literatura sobre perturbações persistentes do neurodesenvolvimento após exposição a anestésicos de crianças em fase de imaturidade cerebral. Material e Métodos: Realizámos uma pesquisa bibliográfica em diversas bases de dados (PubMed, SciELO e Cochrane Library), utilizando os termos ‘Pediatric anesthesia OR Pediatric anesthetic OR Developing brain anesthetic OR Developing brain anesthesia AND behavior disorders’ e foram incluídos os estudos em humanos, referentes a efeitos persistentes no neurodesenvolvimento após exposição a anestésicos nos primeiros quatro anos de idade. Resultados: Dez estudos retrospetivos cumpriram os critérios de inclusão. Destes, sete sugerem alteração do neurodesenvolvimento por exposição de criança pequena à anestesia, por oposição aos resultados obtidos pelos restantes três. Discussão: Embora maioritariamente utilizem bases de dados amplas, os estudos encontrados são retrospetivos, variam nos grupos teste, incluem variáveis de confusão por vezes contornáveis e alguns apresentam incorreções na escolha da população teste e controlo que podem comprometer a fiabilidade dos resultados. Conclusão: As numerosas limitações dos poucos estudos clínicos disponíveis fazem com que a informação reportada ainda se considere insuficiente para mudar a prática clínica atual. No entanto, sendo indiscutível que se mantêm as recomendações para providenciar anestesia quando necessária, independentemente da idade, os alertas encontrados na literatura são preocupantes, existindo indicação para que sempre que possível sejam ponderadas alternativas que possam contribuir para diminuir os riscos da exposição anestésica.

  18. OV-Wav: um novo pacote para análise multiescalar em astronomia

    NASA Astrophysics Data System (ADS)

    Pereira, D. N. E.; Rabaça, C. R.

    2003-08-01

    Wavelets e outras formas de análise multiescalar têm sido amplamente empregadas em diversas áreas do conhecimento, sendo reconhecidamente superiores a técnicas mais tradicionais, como as análises de Fourier e de Gabor, em certas aplicações. Embora a teoria dos wavelets tenha começado a ser elaborada há quase trinta anos, seu impacto no estudo de imagens astronômicas tem sido pequeno até bem recentemente. Apresentamos um conjunto de programas desenvolvidos ao longo dos últimos três anos no Observatório do Valongo/UFRJ que possibilitam aplicar essa poderosa ferramenta a problemas comuns em astronomia, como a remoção de ruído, a detecção hierárquica de fontes e a modelagem de objetos com perfis de brilho arbitrários em condições não ideais. Este pacote, desenvolvido para execução em plataforma IDL, teve sua primeira versão concluída recentemente e está sendo disponibilizado à comunidade científica de forma aberta. Mostramos também resultados de testes controlados ao quais submetemos os programas, com a sua aplicação a imagens artificiais, com resultados satisfatórios. Algumas aplicações astrofísicas foram estudadas com o uso do pacote, em caráter experimental, incluindo a análise da componente de luz difusa em grupos compactos de galáxias de Hickson e o estudo de subestruturas de nebulosas planetárias no espaço multiescalar.

  19. Twenty Years of Autologous Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma: A Single Portuguese Center Experience.

    PubMed

    Dantas Brito, Margarida; Campilho, Fernando; Branca, Rosa; Vaz, Carlos; Roncon, Susana; Campos, António

    2016-03-01

    Introdução: O linfoma não Hodgkin difuso de grandes células B pode ser curado em 60% - 70% dos doentes. O transplante autológo de progenitores hematopoiéticos é o tratamento de intenção curativa standard à recidiva. Este tratamento intensivo após primeira remissão num grupo selecionado de doentes de alto risco é controverso e fez parte da estratégia do nosso Serviço durante alguns anos. Material e Métodos: Estudo retrospectivo, consulta do processo clínico. Resultados: Este estudo analisa o outcome de 113 doentes transplantados entre 1992 e 2012. Formaram-se quatro grupos com base no status pré-transplante: a) primeira remissão completa após 1 ciclo de quimioterapia (n = 64); b) segunda remissão completa após ≥ duas linhas de quimioterapia (n = 15); c) segunda remissão completa (n = 15); d) doença mais avançada (n = 19). O protocolo de quimioterapia de primeira linha mais utilizado foi R-CHOP (n = 71) e CHOP (n = 28). O seguimento mediano foi de 34 meses (1 - 221). Aos cinco anos a sobrevivência global foi de 73% (± 5) e a sobrevivência livre de progressão 75% (± 5). Conclusão: A imunoquimioterapia convencional seguida de transplante autólogo é uma opção segura e eficaz no tratamento de casos selecionados de linfoma difuso de grandes células B. Na nossa casuística cerca de 70% dos doentes de alto risco atingiram remissões duráveis com esta estratégia terapêutica.

  20. Exploration Technology Program plans and directions

    NASA Technical Reports Server (NTRS)

    Aldrich, Arnold; Rosen, Robert; Craig, Mark; Mankins, John C.

    1990-01-01

    A summary of the proposed Space Exploration Initiative (SEI) needs that have been identified is presented along with a detailed review of the status of SEI technology planning. Plans are also being formulated to implement an Exploration Technology Program (ETP) that will develop the major technologies required for SEI. The ETP will provide in the near term clear demonstrations of potential exploration technologies, results of research to support SEI architecture decisions, and a foundation of mature technology that is ready to be applied in the first round of SEI missions. A family of functional building blocks has been defined from which both lunar and Mars SEI mission architectures can be constructed.

  1. [The Role of Aspirin in Preeclampsia Prevention: State of the Art].

    PubMed

    Campos, Ana

    2015-01-01

    Introdução: O papel do ácido acetilsalicílico (AAS ou aspirina) na prevenção das complicações associadas à pré-eclâmpsia tem sido objeto de estudos e de controvérsias ao longo de 30 anos. Os primeiros trabalhos de investigação acerca do papel da placenta na génese da pré-eclâmpsia surgiram em finais dos anos 70 e assinalavam um aumento da atividade plaquetária e alteração da síntese das prostaglandinas, como consequência da deficiente adaptação da placenta. Ao longo dos últimos 20 anos do século XX, sucederam-se estudos de investigação acerca do papel profilático da aspirina na redução do risco de pré-eclâmpsia. Material e Métodos: Para analisar os trabalhos publicados sobre o uso da aspirina na prevenção da pré-eclâmpsia, bem como sobre a dose mais adequada e momento de administração, foram consultados apenas estudos prospetivos, revisões sistemáticas e meta-análises através das seguintes fontes pesquisa (PubMed, Cochrane, Embase). Os artigos citados foram considerados os mais relevantes. Os trabalhos foram divididos em dois grupos: no primeiro foram incluídos os trabalhos em que a aspirina era administrada até às 16 semanas e o segundo, com início de administração por um período mais alargado. Resultados e Discussão: No primeiro grupo, com menor número de casos, mas com início mais precoce de administração do fármaco, até às 16 semanas, concluiu-se que a aspirina poderia ter um papel positivo na redução de risco de gravidade da pré-eclâmpsia; o segundo grupo, com maior número de casos nos estudos, mas com condições menos restritas de entrada e de tempo de início do fármaco, teve resultados mais controversos. As meta-análises destes estudos concluíram que os resultados favoráveis estavam associados às condições de e momento da administração. Conclusão: Não existindo ainda alternativas ou fármacos que lhe possam ser associados, a aspirina em baixas doses (80 a 150 mg/ dia) ao deitar

  2. [Successful pregnancies outcomes with the use of in vitro fertilization after Essure® unilateral hydrossalpinx occlusion].

    PubMed

    Guedes-Martins, Luís; Mesquita-Guimarães, Joana; Barreiro, Márcia

    2014-01-01

    Introdução: Desde há duas décadas que assistimos à publicação de vários estudos dedicados à avaliação da influência da hidrossalpinge nos resultados de técnicas de transferência de embriões. O objectivo deste trabalho é apresentar os resultados do tratamento e vigilância gestacional em mulheres com história de infertilidade - associada a hidrossalpinge unilateral, visível no exame ecográfico transvaginal - submetidas a oclusão unilateral com Essure® e tratamento subsequente com fertilização in vitro. Material e Métodos: Análise prospectiva de uma amostra constituída por seis mulheres, com antecedentes de infertilidade e hidrossalpinge unilateral, entre Abril de 2010 e Maio de 2013. Em todos os casos procedemos a exclusão de hidrossalpinge recorrendo à colocação unilateral de um dispositivo Essure® por via histeroscópica antes da realização de um ciclo para fertilização in vitro. Resultados: Das seis doentes submetidas a fertilização in vitro, quatro engravidaram (66,7%). Destas, registaram-se duas gravidezes de termo sem intercorrências até ao parto e duas gravidezes encontram-se em vigilância, sem intercorrências conhecidas até à data. Das doentes que não engravidaram após fertilização in vitro (n = 2, 33,3%), uma engravidou espontaneamente durante a vigilância subsequente. Discussão: O avanço da histeroscopia no tratamento de hidrossalpinge, recorrendo à implantação do dispositivo Essure®, representa uma alternativa válida à abordagem laparoscópica. Conclusão: Este estudo sugere que a oclusão tubar unilateral, induzida pelo dispositivo Essure®, melhora os resultados do tratamento com fertilização in vitro em casos de infertilidade associada a hidrossalpinge unilateral, visível no exame ecográfico transvaginal.

  3. Late stillbirth: a ten year cohort study.

    PubMed

    Robalo, Raquel; Pedroso, Célia; Amaral, Njila; Soares, Clara

    2013-01-01

    Introdução: A morte fetal tardia é um acontecimento que se mantém na prática diária, apesar de protocolos de vigilância pré-natal e intraparto. Objectivo: Análise dos factores que contribuíram para a causa principal ou condições associadas a morte fetal tardia num período de 10 anos Métodos: Coorte retrospectiva de 208 gestações tardias simples, cujo parto em unidade terciária de cuidados perinatais resultou no nascimento de um nado morto, num período de dez anos. Através de consulta de processo clínico foram analisados dados clínicos, laboratoriais e resultados de estudo anatomo-patológico feto-placentário. Resultados: A incidência de morte fetal tardia foi de 3,5 por cada 1000 nascimentos. Não foram encontradas quaisquer tendências na incidência de MF tardia ao longo do tempo de estudo. Em 12 (5,8%) casos a morte fetal foi um acontecimento intraparto e 72 (35%) eram gestações de termo. Em 14% a gravidez não foi vigiada. A IG média de diagnóstico foi 34 semanas. A principal causa de morte associou-se a patologia fetal, tendo sido identificados factores fetais em 59 casos, destes 25% foram considerados leves para a idade gestacional. Em 24.5% dos casos a causa de morte foi inexplicada. Identificaram-se factores de risco materno em 21% dos casos, a patologia hipertensiva foi frequente e foi associada a idade gestacional precoce (p = 0,028). Conclusões: Não houve oscilações na incidência de morte fetal tardia ao longo dos dez anos avaliados. A incidência foi de 3,5‰, idêntica à descrita em países desenvolvidos. Cerca de um quarto das mortes fetais foram inexplicadas. A patologia materna mais frequente foi a hipertensão crónica.

  4. [Streptococcus pneumoniae Vaccination in Children and Adolescents at High Risk of Invasive Pneumococcal Disease].

    PubMed

    Tendais-Almeida, Marta; Ferreira-Magalhães, Manuel; Alves, Inês; Tavares, Margarida; Azevedo, Inês

    2015-01-01

    Introdução: Em Portugal, a vacinação anti-pneumocócica é gratuita e recomendada pela Direção-Geral da Saúde na população pediátrica de alto risco para doença invasiva pneumocócica. O objetivo deste estudo foi analisar o cumprimento vacinal numa população pediátrica seguida em consulta hospitalar. Material e Métodos: Estudo observacional transversal, em crianças com diagnóstico de alto risco de doença invasiva pneumocócica e consulta num hospital nível três, entre julho e dezembro de 2014. Os dados foram obtidos através do processo clínico, Boletim Individual de Saúde e Plataforma de Dados da Saúde®. Resultados: Dos 122 participantes, 95,9% realizaram, pelo menos, uma dose de vacina mas, destes, só 64,8% efetuaram o esquema completo. O cumprimento do esquema vacinal foi melhor nos de idade inferior a cinco anos (p < 0,01). A proporção de crianças com esquema completo foi de: 100% nas hemoglobinopatias, 100% nas infeções por vírus da imunodeficiência humana, 66,7% nos prematuros com idade gestacional ⤠28 semanas, 62,5% nos esplenectomizados e 54,7% na síndrome de Down. As crianças têm mais esquemas completos quando são seguidas em consulta de Infeciologia (100%) e de Pneumologia pediátricas (88,2%). O grupocom idade superior a cinco anos está mais vacinado com a vacina polissacarida 23-valente do que o dos 2-5 anos (74,5% vs 40,5%; p < 0,01).Discussão: A maioria da nossa população de alto risco para doença invasiva pneumocócica efetuou vacinação anti-pneumocócica, mas apenas dois terços completaram o esquema recomendado, sendo a maior falha na administração da vacina polissacarida 23-valente. Conclusões: Embora estes resultados sejam melhores do que em países europeus com recomendações semelhantes, é necessário explorar as causas das falhas observadas para otimizar a vacinação.

  5. [The Epidemiology of Dementia and Alzheimer Disease in Portugal: Estimations of Prevalence and Treatment-Costs].

    PubMed

    Santana, Isabel; Farinha, Filipa; Freitas, Sandra; Rodrigues, Vítor; Carvalho, Ålvaro

    2015-01-01

    Introdução: A incidência e prevalência de demência e de Doença de Alzheimer aumentam com a idade, duplicando a cada cinco anos após a sexta década de vida. Portugal é um país envelhecido, previsivelmente com um número crescente de casos de demência. No entanto, os dados epidemiológicos são escassos e os estudos sobre os custos da doença praticamente inexistentes. Propomo-nos apresentar uma estimativa actualizada da prevalência de demência/ Doença de Alzheimer em Portugal e inferir, a partir da prescrição específica para demência, o número de diagnósticos efectivos e os encargos financeiros com esses medicamentos.Material e Métodos: ÃÄ população residente em Portugal (2013), aplicámos os valores de prevalência de demência para a Europa Ocidental (estudo da AlzheimerâÄôs Disease International). A estimativa dos diagnósticos efectivos de Doença de Alzheimer e dos encargos financeiros com medicação específica baseou-se nas informações do Intercontinental Marketing Services Health (IMSH) âÄì 2013.Resultados: O número estimado de Portugueses com mais de 60 anos e com demência foi 160287, o que corresponde a 5,91% deste universo populacional. Sabendo que a Doença de Alzheimer representa 50-70% dos casos, inferimos que existirão entre 80144 e 112201 doentes. Por outro lado, os dados da IMSH indicam que estarão diagnosticados e a receceber anti-demenciais 76250 doentes, representando um encargo financeiro de 37 MâǬ/ano.Conclusão: O envelhecimento da população incrementa o número de casos de demência. Aparentemente, nem todos os doentes com Doença de Alzheimer recebem a medicação aconselhada, sugerindo que esta condição ainda está sub-diagnosticada. A evolução tem sido positiva, com incremento do número de doentes tratados e redução dos custos com fármacos específicos.

  6. 78 FR 3399 - Draft 2012 Marine Mammal Stock Assessment Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ...; sei whale, Nova Scotia stock; minke whale Canadian east coast stock; sperm whale, North Atlantic stock... and PBR. The abundance estimate for sei whale, Nova Scotia stock, in the draft 2012 SAR (77 FR...

  7. Geoacoustic Inversion and Source Localization in a Randomly Fluctuating Shallow Water Environment

    DTIC Science & Technology

    2010-06-01

    with a standard deviation of 570 m. 2.2 SVV06 experiment data analysis: Sei whale localization Comparatively little is known about sei whale ...large number of sei whale calls were unexpectedly collected during the SW06 experiment, which introduced the first evidence of sei whales in this...shallow water region. Using the normal mode approach developed in this project, we are able to track the remote locations of these whales up to tens of

  8. [Giardia duodenalis and chronic malnutrition in children under five from a rural area of Guinea-Bissau].

    PubMed

    Centeno-Lima, Sónia; Rosado-Marques, Vítor; Ferreira, Filipa; Rodrigues, Ruben; Indeque, Benjamim; Camará, Idrissa; De Sousa, Bruno; Aguiar, Pedro; Nunes, Baltazar; Ferrinho, Paulo

    2013-01-01

    Introdução: A desnutrição e as infecções por parasitas intestinais como Giardia duodenalis coexistem nas mesmas regiões geográficas, atingindo maiores prevalências em países em desenvolvimento. O ciclo da desnutrição e infecção implica que ambas as condições se podem agravar mutuamente e comprometer o crescimento e desenvolvimento das crianças, com especial relevância para as menores de cinco anos. O objectivo do presente estudo foi investigar a associação entre a desnutrição crónica e a infecção por G. duodenalis em crianças de uma comunidade rural da Guiné-Bissau.Material e Métodos: Realizou-se um estudo de caso-controlo que incluiu 109 crianças com idades entre os 0 e os 59 meses de uma comunidade rural da Guiné-Bissau. A avaliação antropométrica das crianças em estudo permitiu identificar 31 casos de desnutrição crónica (z-score estatura para a idade < -2) e 78 controlos (z-score estatura para a idade ≥ -2). Foi realizado exame microscópico de fezes para a detecção e identificação de G. duodenalis e de outros parasitas.Resultados: Foi detectada infecção por G. duodenalis em 29,0% (9/31) dos casos e 35,9% (28/78) dos controlos. Não foi encontrada associação entre a infecção por G. duodenalis e a desnutrição crónica nas crianças em estudo.Discussão e Conclusão: Os resultados obtidos mantêm em aberto o interesse em desenhar estudos que explorem esta associação em diferentes regiões e contextos epidemiológicos, apontando para a reflexão sobre a importância dos critérios de definição de desnutrição e concomitantemente da análise subsequente.

  9. Cytomegalovirus infection and cervical cancer: from past doubts to present questions.

    PubMed

    Marinho-Dias, Joana; Sousa, Hugo

    2013-01-01

    Introdução: Desde os anos 60 que o Citomegalovírus tem sido estudado pelo potencial papel no desenvolvimento de cancro do colo do útero. Após várias décadas de estudos e relatos da presença de DNA viral em amostras cervico-vaginais, ainda permanecem dúvidas sobre qual a prevalência do Citomegalovírus no cólo do útero e se este pode ser um cofator da carcinogénese. Métodos: Nesta Revisão Sistemática pretendemos descrever a prevalência de Citomegalovírus em amostras cervicais, revendo todos os estudos publicados entre 1980 e 2011 que descrevem a infecção por Citomegalovírus em amostras cervicais e o desenvolvimento de lesões/carcinoma invasor. As frequências da infecção por Citomegalovírus foram calculadas de acordo com a região no mundo. Resultados: Este estudo revelou que a frequência bruta da infecção por Citomegalovírus no cólo do útero foi de 18,9% em todas as amostras e 36,5% em mulheres HPV positivas. A infecção por Citomegalovírus está presente em todas as diferentes lesões: 17,4% em normais/cervicite, 28,0% em LSIL, 19,7% em HSIL e 44,4% em CIS/ICC. A frequência global variou de 1,58% a 61,0%, com uma maior incidência em países menos desenvolvidos. Conclusão: Neste estudo, verificou-se uma elevada frequência de casos positivos para Citomegalovírus em todos os tipos de amostras cervico-vaginais, com maior incidência em mulheres infectadas por HPV e em casos de cancro. Assim, são necessários mais estudos para esclarecer se a infecção por Citomegalovírus é uma infecção oportunista ou se contribui para a imunossupressão favorecendo a carcinogénese associada ao HPV.

  10. A Neurologist's Hard Day's Work: Impact of Inpatient Neurology Consultation in a Tertiary Hospital.

    PubMed

    Rocha, Helena; Monteiro, Ana; Gomes, Tiago; Grilo, Miguel; Carvalho, Marta

    2016-01-01

    Introdução: A consulta de neurologia realizada a doentes hospitalizados sob a responsabilidade de outras especialidades é um trabalho exigente mas muitas vezes sub-valorizado e pouco documentado. Este estudo pretendeu avaliar o impacto das consultas internas de neurologia num hospital português e, consequentemente, a performance do nosso Serviço no que diz respeito a esta matéria. Material e Métodos: Foi conduzido um estudo retrospetivo durante o ano de 2013 através da revisão de dados clínicos e demográficos. Resultados: Ao longo de um ano, os neurologistas no nosso Serviço avaliaram 632 doentes internados. As principais razões para o pedido de consulta foram a alteração do estado mental/comportamental, défice neurológico focal e crises epiléticas. Os pedidos de avaliação provieram principalmente de serviços médicos mas também de Unidades de Cuidados Intensivos e Intermédios. Os neurologistas sugeriram investigação adicional em cerca de 50% dos doentes; alterações terapêuticas foram efetuadas numa proporção semelhante de doentes. No final da consulta foi possível estabelecer um novo diagnóstico em 63% dos casos, sendo os mais frequentes manifestação neurológica de doenças sistémicas, epilepsia e doença vascular cerebral. Tal intervenção teve impacto no cuidado de 68% dos doentes. Discussão e Conclusão: Diferentes estudos na literatura suportam os nossos achados, enfatizando que esta atividade tem benefícios diretos no tratamento dos doentes e que é custo-efetiva. Os nossos resultados sugerem que a atividade de consultadoria interna da Neurologia resulta em intervenções úteis para a gestão clínica dos doentes internados.

  11. Adverse events in the intensive care unit: impact on mortality and length of stay in a prospective study.

    PubMed

    Roque, Keroulay Estebanez; Tonini, Teresa; Melo, Enirtes Caetano Prates

    2016-10-20

    This study sought to evaluate the occurrence of adverse events and their impacts on length of stay and mortality in an intensive care unit (ICU). This is a prospective study carried out in a teaching hospital in Rio de Janeiro, Brazil. The cohort included 355 patients over 18 years of age admitted to the ICU between August 1, 2011 and July 31, 2012. The process we used to identify adverse events was adapted from the method proposed by the Institute for Healthcare Improvement. We used a logistical regression to analyze the association between adverse event occurrence and death, adjusted by case severity. We confirmed 324 adverse events in 115 patients admitted over the year we followed. The incidence rate was 9.3 adverse events per 100 patients-day and adverse event occurrence impacted on an increase in length of stay (19 days) and in mortality (OR = 2.047; 95%CI: 1.172-3.570). This study highlights the serious problem of adverse events in intensive care and the risk factors associated with adverse event incidence. Resumo: Este estudo teve como objetivo avaliar a ocorrência de eventos adversos e o impacto deles sobre o tempo de permanência e a mortalidade na unidade de terapia intensiva (UTI). Trata-se de um estudo prospectivo desenvolvido em um hospital de ensino do Rio de Janeiro, Brasil. A coorte foi formada por 355 pacientes maiores de 18 anos, admitidos na UTI, no período de 1º de agosto de 2011 a 31 de julho de 2012. O processo de identificação de eventos adversos baseou-se em uma adaptação do método proposto pelo Institute for Healthcare Improvement. A regressão logística foi utilizada para analisar a associação entre a ocorrência de evento adverso e o óbito, ajustado pela gravidade do paciente. Confirmados 324 eventos adversos em 115 pacientes internados ao longo de um ano de seguimento. A taxa de incidência foi de 9,3 eventos adversos por 100 pacientes-dia, e a ocorrência de evento adverso impactou no aumento do tempo de internação (19

  12. [Relational and reproductive trajectories leading to adolescent pregnancy in Portugal: a national and regional characterization].

    PubMed

    Pires, Raquel; Pereira, Joana; Pedrosa, Anabela Araújo; Bombas, Teresa; Vilar, Duarte; Vicente, Lisa; Canavarro, Maria Cristina

    2014-01-01

    Introdução: Este estudo pretendeu caracterizar as trajetórias relacionais e reprodutivas conducentes à gravidez na adolescência em Portugal, explorando a existência de especificidades regionais.Material e Métodos: O estudo decorreu entre 2008 e 2013 em 42 serviços de saúde públicos. A amostra, nacionalmente representativa, incluiu 459 grávidas com idades entre os 12 e os 19 anos. Os dados foram obtidos por autorrelato, através de uma ficha de caracterização construída para o efeito.Resultados: Independentemente de terem tido um (59,91%) ou múltiplos parceiros sexuais (40,09%), as adolescentes engravidaram de forma mais frequente numa relação de namoro, utilizando contraceção à data da conceção e tendo identificado a falha contracetiva que esteve na origem da gravidez (39,22%). A nível regional, outras trajetórias surgiram com elevada prevalência, refletindo opções como a decisão de engravidar (Alentejo/Açores), a não utilização de contraceção (Centro/Madeira) ou a sua utilização ineficaz sem que a falha contracetiva fosse identificada (Madeira). As relações de namoro revelaram-se maioritariamente duradouras (> 19 meses), com homens mais velhos (> 4 anos) e fora do sistema de ensino (75,16%); estes resultados foram particularmente expressivos quando a gravidez foi planeada.Discussão: O conhecimento gerado por este estudo reflete a necessidade de investir em abordagens preventivas que atendam às necessidades específicas das jovens de cada região e integrem a população masculina de maior risco.Conclusão: Os nossos resultados podem contribuir para o delineamento de políticas de saúde mais eficazes e para uma atuação multidisciplinar mais informada ao nível da educação sexual e do planeamento familiar nas diferentes regiões do país.

  13. Assessment of Suicidal Behavior in a Psychiatric Emergency Room in Lisbon.

    PubMed

    Marques, João Gama; Guerreiro, Diogo Frasquilho; Sampaio, Daniel

    2015-01-01

    Introdução: Alguns estudos têm alertado para a sobrecarga de tentativas de suicídio nas urgências médicas. Neste estudocaracterizamos os doentes suicidas numa urgência médica portuguesa. Material e Métodos: Durante três anos, todos os doentes observados pelo primeiro autor, em urgências médicas, após tentativa suicida, foram incluídos no estudo. A intencionalidade da tentativa suicida foi determinada com a Pierce Suicide Intent Scale. O seguimento foi registado recorrendo ao processo clínico, e o nível de satisfação a chamada telefónica. Resultados: Dos 120 doentes incluídos 70,8% eram mulheres e a média de idades foi 42,35 anos. A intencionalidade suicida (Pierce Suicide Intent Scale) foi baixa em 30,1%, média em 59,3% e elevada em 10,6%. Os principais preditores de intencionalidade suicida foram: género masculino (p < 0,001), história familiar de suicídio (p < 0,01), divórcio ou viuvez (p < 0,013) e doença mental grave (p < 0,015). Em 41,6% dos doentes não se apurou seguimento. Quanto à satisfação, apenas 19,5% deram resposta válida: 2,7% 'ligeiramente satisfeito', 4,4% 'moderadamente satisfeito', e 12,5% 'muito satisfeito'. Discussão: A Pierce Suicide Intent Scale é um instrumento útil na avaliação do comportamento suicida na urgência médica. Ocomportamento suicida de elevada intencionalidade está relacionado com género masculino, problemas sociais e antecedentes psiquiátricos pessoais e familiares. Conclusão: Os registos administrativos da urgência médica são ainda pouco rigorosos. As variáveis relacionadas com intencionalidade suicida são as mesmas que são descritas noutros países. Dos doentes a que conseguimos chegar, um quinto mostrou-se satisfeito com o seguimento. Mais estudos são necessários para compreender o comportamento suicida em Portugal.

  14. Symptoms and reason for a medical visit in lung cancer patients.

    PubMed

    Gonzalez-Barcala, Francisco Javier; Falagan, José Antonio; Garcia-Prim, Jose Maria; Valdes, Luis; Carreira, Jose Martin; Pose, Antonio; Canive, Juan Carlos; Anton, Diana; Garcia-Sanz, Maria Teresa; Puga, Amalia; Temes, Enrique; Lopez-Lopes, Rafael

    2014-01-01

    Contexto: A Os doentes com o diagnóstico de cancro do pulmão estão habitualmente sintomáticos no momento do diagnóstico, sendo comum que o médico ou o doente não associem essa sintomatologia com a eventualidade de um tumor maligno. Objectivos: Este estudo teve como objectivo a análise dos sintomas de doentes com cancro do pulmão e sua relação com as características pessoais ou com a doença oncológica. Material e Métodos: Foi levado a cabo um estudo retrospectivo englobando todos os doentes com o diagnóstico de cancro do pulmão na Região de Saúde de Pontevedra (Espanha) ao longo de um período de três anos. São analisados os sintomas de apresentação do doente, o motivo de consulta e a concordância entre ambos ou com quaisquer factores correlacionados. Resultados: Foram incluídos no estudo 358 doentes, com uma média etária de 68,7 anos, sendo 87% dos doentes do sexo masculino. Os sintomas iniciais mais comuns foram sintomas constitucionais em 30,4% dos casos, tosse em 20,9% e dor torácica, descrita por 12% dos doentes. O motivo de consulta mais frequente foi dispneia em 22,1% dos doentes, um achado acidental em 15,4% dos doentes e hemoptise em 12,8%. Observou-se uma associação moderada (coeficiente de correlação = 0,495) entre os sintomas iniciais e o motivo de consulta. Conclusões: Uma elevada percentagem de doentes com um diagnóstico de cancro do pulmão apresentou sintomas associados com o tumor no momento do diagnóstico, mesmo num estadio inicial da doença.

  15. Análise da cinemática interna das regiões HII gigantes e das galáxias HII

    NASA Astrophysics Data System (ADS)

    Plana, H.; Telles, E.; Maíz-Apellániz, J.

    2003-08-01

    Neste trabalho nós mostramos os primeiros resultados de um estudo sobre a cinemática das Regiões HII Gigantes (GHIIRs) em galáxias próximas. Essas regiões HII têm um diâmetro médio entre 100 pc e 1000 pc e uma taxa de formação estelar de 106 M¤ / ano sendo equivalente à observada em galáxias de tipo tardio correspondendo a uma taxa de formação estelar por unidade de volume uma ordem de magnitude maior que a observada em regiões HII normais. Usando espectros de fenda longas em várias posições, nós construímos mapas de velocidades, de dispersão e de intensidade para várias linhas de emissão como Ha, Hb, [NII]6584 Å, [OIII]5007 Å e o doublet de [SII], para cinco regiões gigantes: NGC 2403 II e IV, NGC 595, NGC 5461, NGC 5471, NGC 5455. O estudo da cinemática (mapas de velocidades e da dispersão) mostrou, por exemplo, a presença de cascas em expansão em NGC 595 ou perfis de emissão com várias componentes em NGC 5461. Os perfis de emissão também mostram velocidades supersônicas. Os resultados são discutidos em comparação com os de estudos anteriores realizados.

  16. Emerging Technologies for Software-Reliant Systems of Systems

    DTIC Science & Technology

    2010-09-01

    please visit the library on the SEI website (www.sei.cmu.edu/library). i | CMU/SEI-2010-TN-019 Table of Contents Abstract v 1 Introduction 1 2...Levine, A., Smith, R., & Stone, S. The 2010 Horizon Report. Austin, Texas: The New Media Consortium. 2010. http://www.nmc.org/pdf/2010-Horizon- Report.pdf

  17. Science and Engineering Indicators 2010. NSB 10-01

    ERIC Educational Resources Information Center

    Lehming, Rolf F.; Alt, Martha Naomi; Chen, Xianglei; Hall, Leslie; Burton, Lawrence; Burrelli, Joan S.; Kannankutty, Nirmala; Proudfoot, Steven; Regets, Mark C.; Boroush, Mark; Moris, Francisco A.; Wolfe, Raymond M.; Britt, Ronda; Christovich, Leslie; Hill, Derek; Falkenheim, Jaquelina C.; Dunnigan, Paula C.

    2010-01-01

    "Science and Engineering Indicators" (SEI) is first and foremost a volume of record comprising the major high-quality quantitative data on the U.S. and international science and engineering enterprise. SEI is factual and policy neutral. It does not offer policy options, and it does not make policy recommendations. SEI employs a variety…

  18. Operando Measurement of Solid Electrolyte Interphase Formation at Working Electrode of Li-Ion Battery by Time-Slicing Neutron Reflectometry.

    PubMed

    Kawaura, Hiroyuki; Harada, Masashi; Kondo, Yasuhito; Kondo, Hiroki; Suganuma, Yoshitake; Takahashi, Naoko; Sugiyama, Jun; Seno, Yoshiki; Yamada, Norifumi L

    2016-04-20

    We report the first operando measurement of solid electrolyte interphase (SEI) formation at an electrode using in situ neutron reflectometry. The results revealed the growth of the SEI and intercalation of ions during the charge reaction. Furthermore, we propose a way of evaluating the charge used for the SEI formation.

  19. Systems engineering and integration and management for manned space flight programs

    NASA Technical Reports Server (NTRS)

    Morris, Owen

    1993-01-01

    This paper discusses the history of SE&I management of the overall program architecture, organizational structure and the relationship of SE&I to other program organizational elements. A brief discussion of the method of executing the SE&I process, a summary of some of the major lessons learned, and identification of things that have proven successful are included.

  20. 78 FR 19330 - Supplemental Environmental Impact Statement for the Ross In-Situ Uranium Recovery Project in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... statement; request for comment. SUMMARY: By letter dated January 4, 2011, Strata Energy, Inc., (Strata... Statement (Draft SEIS) for the Ross Project. The Draft SEIS is Supplement 5 to NUREG-1910, ``Generic...-415-4737, or by email to pdr.resource@nrc.gov . The Draft SEIS (NUREG-1910, Supplement 5) is...

  1. Status and plans for exploration technology

    NASA Technical Reports Server (NTRS)

    Aldrich, Arnold D.; Rosen, Robert; Harris, Leonard A.; Reck, Gregory M.; Mankins, John C.

    1991-01-01

    The present status of the Space Exploration Initiative (SEI) is discussed. SEI mission planning is reviewed, including various architectural options, their waypoints, and their strategic features. SEI technology needs and issues are examined in order of priority and technology development plans are described.

  2. A Study of Arizona's Teachers of English Language Learners

    ERIC Educational Resources Information Center

    Rios-Aguilar, Cecilia; Gonzalez Canche, Manuel S.; Moll, Luis C.

    2012-01-01

    Background/Context: In September 2007, the Arizona State Board of Education adopted the Structured English Immersion (SEI) model proposed by the Arizona English Language Learner (ELL) Task Force.During the 2008-2009 academic year, it required all school districts to implement the SEI model.The SEI program, best known as the 4-hour English Language…

  3. Science and Engineering Indicators 2012. NSB 12-01

    ERIC Educational Resources Information Center

    National Science Foundation, 2012

    2012-01-01

    Science and Engineering Indicators (SEI) is first and foremost a volume of record comprising the major high-quality quantitative data on the U.S. and international science and engineering enterprise. SEI is factual and policy neutral. It does not offer policy options, and it does not make policy recommendations. SEI employs a variety of…

  4. [Efficacy of the Vaccines Against Human Papillomavirus in Women Older than 24 Years in the Cervix Cancer Prevention].

    PubMed

    Pimenta Ribeiro, Jaime; Borges, Isabel

    2016-06-01

    Introdução: O cancro do colo do útero é o quarto tipo de cancro feminino mais comum e o segundo mais frequente nas mulheres entre os 15 e os 44 anos. A infeção pelo vírus do papiloma humano é condição necessária na quase totalidade dos casos de cancro do colo do útero; trata-se de uma doença sexualmente transmissível e todas as mulheres sexualmente ativas estão em risco de contrair infeção. Atualmente existem três vacinas contra o vírus do papiloma humano, e apesar da sua eficácia estar bem comprovada nas mulheres até aos 25 anos, não está totalmente estabelecida em idades superiores.Material e Métodos: Realizou-se uma revisão da literatura sobre a evidência atual relativa à eficácia das vacinas contra o vírus do papiloma humano nas mulheres com mais de 24 anos na prevenção do cancro do colo do útero e foi avaliada a qualidade da evidência segundo o sistema GRADE.Resultados: Foram identificados dois estudos controlados randomizados relevantes para a análise que envolveram um total de 9 571 participantes – 4 792 no grupo vacinado e 4 779 no grupo controlo – e reportaram dados relativos a 48 meses de follow-up. A redução do risco relativo foi de 41% (95% CI: 29 a 50%), – favorável para o grupo vacinado. Não existiram diferenças entre a segurança e tolerabilidade das vacinas nos grupos vacina e controlo.Conclusão: A evidência atual demonstra que as vacinas contra o vírus do papiloma humano 16 e/ou 18 nas mulheres com mais de 24 e até aos 45 anos apresentam uma eficácia importante na redução do risco de desenvolver infeção persistente e/ou adquirir lesões precursoras de cancro do colo do útero.

  5. [Disciplinary Actions in Gynecology and Obstetrics in the North of Portugal from Year 2008 to 2012].

    PubMed

    Silva, Francisco; Rodrigues E Rodrigues, Manuel; Bernardes, João

    2015-01-01

    Introdução: As ações disciplinares podem ter um impacto significativo na vida dos médicos e dos doentes. O objetivo deste trabalho foi a avaliação das ações disciplinares em Ginecologia e Obstetrícia ocorridas na região norte de Portugal nos anos 2008 a 2012.Material e Métodos: Estudo descritivo retrospetivo baseado nos dados anonimizados disponíveis nos relatórios anuais de atividades do Conselho Disciplinar da Seção Regional Norte da Ordem dos Médicos dos anos 2008 a 2012. Calculámos a proporção de ações disciplinares em Ginecologia e Obstetrícia sobre o número total de especialistas inscritos. Avaliámos também os tipos de queixoso, de arguido, de instituição, de queixa e de decisão envolvidos. Para comparação de proporções utilizámos intervalos de confiança de 95%.Resultados: De 2008 a 2012, registou-se um total de 1040 ações disciplinares na região norte de Portugal. A Ginecologia e Obstetrícia foi a quarta especialidade mais afetada, com 54 queixas, 43 das quais relacionadas com alegada negligência médica e a mais afetada, se considerarmos apenas este tipo de queixa. Os queixosos e os arguidos mais frequentes foram, respetivamente, doentes em nome próprio e profissionais do sexo feminino, com idade compreendida entre os 41 e 60 anos. Das 54 ações disciplinares registadas, 52 foram concluídas sem penalização e duas aguardam decisão.Discussão: Os resultados estão genericamente de acordo com os de outros autores.Conclusões: A Ginecologia e Obstetrícia foi a quarta especialidade com maior risco de ação disciplinar na região norte de Portugal nos anos 2008 a 2012 e a primeira se considerarmos só as queixas de alegada negligência médica. Todas as ações disciplinares foram arquivadas, sem penalização dos médicos visados, com exceção de duas que se encontram ainda em avaliação.

  6. [Identification and preservation of parathyroid glands in cadaver parts].

    PubMed

    Melo, Catarina; Bernardes, António; Carvalho, Lina

    2013-01-01

    Introdução: É indispensável ter um conhecimento profundo da morfologia da glândula tiróide e das estruturas com ela relacionadas no compartimento anterior do pescoço, para minimizar a morbilidade decorrente da cirurgia da tiróide, nomeadamente a lesão das glândulas paratiróides e dos nervos laríngeos. Este estudo pretendeu identificar glândulas paratiróides em peças de cadáver, confirmando-as histologicamente.Material e Métodos: Foram usadas 20 peças de cadáver para simular tiroidectomias. Durante a dissecção, foram isoladas as glândulas tiróides e eventuais glândulas paratiróides, que foram submetidas a estudo histológico.Discussão: Foram dissecadas 20 peças de cadáver (regiões cervicais anteriores), sendo isolados 48 fragmentos que correspondiam a eventuais glândulas paratiróides, dos quais 35 foram confirmados histologicamente como sendo efectivamente paratiróides. Os 20 casos foram, então, divididos em três grupos, de acordo com o número de paratiróides confirmadas histologicamente. No primeiro grupo, constituído por 11 casos, todas as eventuais paratiróides foram confirmadas. No segundo grupo, constituído por seis casos, apenas algumas paratiróides foram confirmadas. No terceiro grupo, constituído por três casos, nenhuma das eventuais paratiróides isoladas era efectivamente paratiróide. Em sete das 20 glândulas tiróides isoladas, foram identificadas oito paratiróides no estudo histológico: quatro sub-capsulares; três extra-capsulares e uma intra-tiróideia. As dimensões das paratiróides não tinham relação estatisticamente significativa.Conclusão: O conhecimento da anatomia das estruturas do compartimento central do pescoço e das suas variações mais frequentes diminui, mas não elimina a morbilidade da cirurgia da tiróide, nomeadamente a excisão iatrogénica das paratiróides, cuja dificuldade de identificação foi evidenciada nas peças dissecadas.

  7. Revista de Documentacao de Estudos em Linguistica Teorica e Aplicada, 1999 (Journal of Documentary Studies in Linguistic Theory and Application, 1999).

    ERIC Educational Resources Information Center

    Barbara, Leila, Ed.; Rajagopalan, Kanavillil, Ed.

    1999-01-01

    These issues include the following articles: "Portuguese Philology in Brazil" (Heitor Megale, Cesar Nardelli Cambraia); "Implications of Brazilian Portuguese Data for Current Controversies in Phonetics: Towards Sharpening Articulatory Phonology" (Eleonora Cavalconte Albano); "Morphological Studies in Brazil: Data and…

  8. Revista de Documentacao de Estudos em Liguistica Teorica e Aplicada, 1998 (Journal of Documentary Studies in Linguistic Theory and Application, 1998).

    ERIC Educational Resources Information Center

    Barbara, Leila, Ed.; Rajagopalan, Kanavillil, Ed.

    1998-01-01

    This document consists of three issues of DELTA, comprising its entire output for 1998. DELTA is a journal of theoretical and applied linguistics and covers a wide variety of material related to language, speech, and education. The journal publishes only original research and ideas presented in the form of articles, debates, squibs, overviews,…

  9. Prolegomenos a um estudo da lingua brasileira nos terreiros de origem africana (Prolegomena to a Study of the Brazilian Language of the Voodoo Rites of African Origin).

    ERIC Educational Resources Information Center

    Megenney, William W.

    Determination of the authenticity of lexical items with Sub-Saharan origin in the voodoo rites of candomble and umbanda in Brazil requires establishing a socio-historical basis for the African diaspora and the current configuration of terreiros. The terreiros demonstrate varying linguistic repertoires according to their affiliation with candomble…

  10. Estudo da Oscilação de Neutrinos Muônicos Usando Dados Atmosféricos e de Acelerador nos Experimentos MINOS e MINOS+

    SciTech Connect

    Medeiros, Michelle Mesquita de

    2015-01-01

    The MINOS (Main Injector Neutrino Oscillation Search) and MINOS+ experiments were designed to study neutrino oscillations using a muon neutrino beam which is detected in two different locations, in the Near Detector and in the Far Detector. The distance between the detectors allows the beam neutrinos to oscillate to a different flavor. Therefore, a disappearance of the muon neutrinos from the beam is observed in the Far Detector. The Far Detector has a special apparatus which makes possible the selection of atmospheric neutrinos and antineutrinos. These come from interactions of cosmic rays with the Earth’s atmosphere. Both detectors have a magnetic field, allowing the distiction between neutrinos and antineutrinos interactions. This thesis presents the first combined analysis of data from the MINOS and MINOS+ experiments. We have analyzed the combined neutrino energy spectrum from the complete MINOS beam data and the first, more energetic, MINOS+ beam data. The disappearance of the muon neutrinos was observed and the data has shown to be congruent with the oscillation model. Beyond that, we have measured the atmospheric oscillation parameters of the beam and atmospheric neutrinos and antineutrinos from MINOS combined with the atmospheric neutrinos and antineutrinos from MINOS+. Assuming the same oscillation parameters for both neutrinos and antineutrinos, the best fit is obtained for inverted hierarchy and lower octant with Δm2 32 = 2:37 X 10-3 eV2 and sin2 θ 23 = 0:43, and the limits m2 32 = [2,29 - 2,49] 10-3 eV2 (68%) and sin2 θ23 = 0.36 - 0.66 (90%). These results are the most precise measurement of the neutrinos mass splitting using muon neutrino disappearance data only.

  11. [Alcohol consumption in the schooled youth: an old question revisited].

    PubMed

    Marques, Marilia; Viveiro, Carolina; Passadouro, Rui

    2013-01-01

    Introdução: É principalmente na adolescência que os jovens procuram novas experiências. O consumo de álcool surge neste contexto como uma atitude banalizada e, por vezes, até incitada socialmente, já que o acesso a bebidas alcoólicas é facilitado. Associa-se a comportamentos de risco, com consequências sérias do ponto de vista de saúde pública. O nosso objectivo é caracterizar os padrões de consumo de álcool numa amostra de adolescentes residentes no distrito de Leiria. Material e Métodos: Estudo transversal, descritivo, através de um questionário anónimo aplicado em alunos do distrito de Leiria. Resultados: A amostra final foi de 405 indivíduos, 56% do sexo feminino, com idade média de 16,5 ± 1 anos (15 - 18 anos). A maioria (48%) frequentava o 10º ano, 15,4% reprovaram pelo menos uma vez. Noventa por cento dos inquiridos afirmaram ter experimentado bebidas alcoólicas pelo menos uma vez. O primeiro contacto com o álcool ocorreu preferencialmente com amigos (63%), na maioria dos casos por curiosidade (47%). Os resultados apontaram para maiores índices de consumo de cerveja e maior insucesso escolar no género masculino, comparativamente ao género feminino, que apresentava um maior consumo de bebidas brancas. Em ambos os sexos verificou-se uma tendência para o binge drinking. A maioria dos inquiridos (60%) consumia 2 a 3 copos por ocasião mas cerca de 30% dos rapazes afirmaram consumir mais de quatro copos por ocasião (7% até ficarem embriagados), tendência que não se verificou nas raparigas. A maioria dos consumos efectuou-se nos bares e discotecas (60%). Constatou-se que 41% dos inquiridos saíam à noite, e 70% ingeriam bebidas alcoólicas; 66% começaram a sair à noite entre os 13 e os 15 anos de idade e 9% já tinham experimentado drogas pelo menos uma vez. Os jovens estão mal informados quanto ao consumo do álcool: 20% achavam que as bebidas alcoólicas podem matar a sede, 34% acreditavam que abrem o apetite, 15

  12. [Acute respiratory distress syndrome: case series, two years at an intensive care unit].

    PubMed

    Taborda, Lúcia; Barros, Filipa; Fonseca, Vitor; Irimia, Manuel; Carvalho, Ramiro; Diogo, Cláudia; Ramos, Armindo

    2014-01-01

    Introdução: A Síndrome de Dificuldade Respiratória Aguda apresenta incidência e mortalidade significativas em Cuidados Intensivos, justificando estudos adicionais, nomeadamente para definição de novas abordagens terapêuticas. Os autores propuseram-se caracterizaros casos duma Unidade de Cuidados Intensivos em dois anos.Material e Métodos: Procedeu-se a um estudo observacional retrospectivo dos casos admitidos numa Unidade de Cuidados Intensivos, cumprindo os critérios diagnósticos da American-European Consensus Conference on ARDS, tendo sido excluídos os não ventilados invasivamente. Pesquisados e submetidos a tratamento estatístico: dados demográficos, etiologia do Síndrome de Dificuldade Respiratória Aguda, comorbilidades, Índices de Gravidade, PaO2/FiO2, modalidades e parâmetros ventilatórios, compliance pulmonar, dias de ventilação mecânica invasiva, corticoterapia, terapêuticas de resgate, complicações, duração do internamento, óbitos.Resultados: Obtiveram-se 40 doentes, com uma mediana de 72,5 anos (amplitude interquartil 22) e um ratio feminino:masculino ≈1:1,86. Cinquenta e cinco por cento dos Síndrome de Dificuldade Respiratória Aguda tiveram etiologia pulmonar. A média do PaO2/ FiO2 mínimo foi 88mm Hg (IC 95%: 78,5-97,6). A média da PEEP máxima aplicada foi 12,4 cmH2O (Desvio Padrão 4,12) e a médiado Volume Corrente máximo utilizado foi 8,2 mL/Kg peso ideal (IC 95%: 7,7-8,6). A mediana dos dias de ventilação mecânica invasiva foi 10. Em 47,5% dos doentes foram administrados corticóides. Em 52,5% foi executado recrutamento alveolar. A complicação mais frequente foi a Pneumonia Associada a Ventilação (20%). A mediana da duração do internamento foi 10,7 dias (amplitude interquartil10,85). Faleceram 60% dos doentes. A probabilidade de outcome favorável ‘não óbito na Unidade de Cuidados Intensivos’ foi 4,4x superior nos doentes sob corticoterapia e 11x superior nos doentes com idade < 65 anos

  13. Conceptuaciones de los estudiantes de las facultades de educacion y ciencias naturales de la Universidad de Puerto Rico, recinto de Rio Piedras, acerca de la ciencia y la pseudociencia

    NASA Astrophysics Data System (ADS)

    Reyes Medina, Hector A.

    Esta investigacion describe las conceptuaciones de los estudiantes de tercer ano o mas a nivel de bachillerato de los programas de Educacion en Ciencia y Ciencias Naturales de la Universidad de Puerto Rico, Recinto de Rio Piedras, acerca de lo establecido en la literatura para distinguir el conocimiento cientifico de las creencias pseudocientificas. Este estudio se guio por un diseno tipo encuesta transversal que permitio conocer de manera consistente las conceptuaciones de los estudiantes encuestados acerca de la Ciencia y la Pseudociencia. Ademas, permitio desarrollar inferencias estadisticas relacionadas a la poblacion de estudio, sus conceptuaciones y su inclinacion teorica en torno al Realismo y al Racionalismo cientifico moderados. El instrumento utilizado fue el Cuestionario acerca de las concepciones de la ciencia y la pseudocienca en estudiantes universitarios, Reyes (2015). Este cuestionario fue validado mediante la recopilacion de diversas fuentes de evidencias, entre estas se encuentran las evidencias basadas en el contenido, el proceso de respuesta, la estructura interna y de constructo. Tambien, se calculo el Alfa de Crombach para la escala total y para cada componente y se realizo un analisis de factores que demostro la presencia de seis componentes claramente definidos de acuerdo a lo esperado sobre las caracteristicas originales del instrumento. Las estadisticas utilizadas fueron descriptivas. Participaron 302 alumnos, de las facultades de educacion y ciencias naturales. Se encontro que las conceptuaciones de los estudiantes de ambas facultades se inclinan en un 66.2% a favor con lo establecido en el modelo teorico en torno al Realismo y al Racionalismo cientifico moderados. Sin embargo, aun hay un 33.8% de los estudiantes de ambas facultades que poseen conceptuaciones distintas al modelo teorico propuesto.

  14. A thermal-electrochemical model that gives spatial-dependent growth of solid electrolyte interphase in a Li-ion battery

    NASA Astrophysics Data System (ADS)

    Liu, Lin; Park, Jonghyun; Lin, Xianke; Sastry, Ann Marie; Lu, Wei

    2014-12-01

    The formation of a SEI layer and its growth cause internal resistance increase and capacity loss, leading to performance degradation of lithium-ion batteries. In order to comprehensively investigate the effects of SEI growth on battery performance, a one-dimensional thermal-electrochemical model was developed. This model is equipped with a growth mechanism of the SEI layer coupled with thermal evolution, based on the diffusional process of the solvent through the SEI layer and the kinetic process at the interface between the solid and liquid phases. The model is able to reveal the effects of diffusivity, reaction kinetics and temperature on SEI layer growth and cell capacity fade. We show that depending on the SEI thickness, the growth can be kinetics-limited or diffusion-limited. With the layer becoming thicker, its growth rate slows down gradually due to increased diffusion resistance. The SEI layer grows faster during charge than discharge due to the difference in the electron flux through the SEI layer and the temperature change during cycling. Temperature rise due to reaction and joule heating accelerates the SEI layer growth, leading to more capacity loss. Our model can provide insights on position-dependent SEI growth rate and be used to guide the strategic monitoring location.

  15. Prevalence and Risk Factors for Iron Deficiency Anemia and Iron Depletion During Pregnancy: A Prospective Study.

    PubMed

    Gomes da Costa, Ana; Vargas, Sara; Clode, Nuno; M Graça, Luís

    2016-09-01

    Introdução: A anemia e a carência de ferro são problemas de saúde globais e são mais frequentes em grávidas, mulheres em idade reprodutiva e crianças. O objetivo deste trabalho consistiu na avaliação da prevalência de anemia ferropénica e dos fatores de risco associados à ferropénia, na primeira metade da gravidez, numa amostra da população portuguesa. Material e Métodos: Estudo prospetivo, conduzido num hospital terciário, que incluiu grávidas até à 20ª semana de gestação. Foram coletados dados demográficos, relativos à gravidez e foram determinados os níveis séricos de hemoglobina e de ferritina no sangue materno. Recorreu-se à análise de regressão logística de variáveis múltiplas para identificar potenciais fatores de risco para ferropénia. Resultados: Foram incluídas 201 grávidas, das quais cinco (2,49%) tinham anemia. Para além disso, 77 grávidas (38,3%) tinham carência de ferro e 22 (10,9%) apresentaram ferropénia grave. A idade materna foi o único fator de risco identificado. O odds ratio foi de 12,99 (95% IC 2,41 - 70,0) para grávidas com idade inferior a 20 anos e de 2,09 (95% IC 1,05 - 4,14), para grávidas com idade superior a 30 anos. Discussão e Conclusão: Na nossa amostra, a prevalência de anemia na primeira metade da gravidez foi inferior à reportada noutros estudos. No entanto, mais de 30% das grávidas apresentaram carência de ferro. A idade materna foi o único fator de risco identificado.

  16. Portuguese Medical Students' Knowledge and Attitudes Towards Homosexuality.

    PubMed

    Lopes, Lucas; Gato, Jorge; Esteves, Manuel

    2016-11-01

    Introdução: A população lésbica, gay, bissexual e transgénero enfrenta ainda preconceito nos cuidados de saúde e, para além disso, os médicos frequentemente referem falta de conhecimento sobre as necessidades de saúde específicas desta população. Este estudo teve como objetivo explorar os fatores associados com as atitudes e conhecimentos dos estudantes de medicina face à homossexualidade em diferentes anos do curso de medicina. Material e Métodos: Foi enviado um questionário online anónimo a todos os estudantes de medicina matriculados na Faculdade de Medicina da Universidade do Porto em dezembro de 2015. O questionário incluía questões sociodemográficas, a Escala Multidimensional de Atitudes face a Lésbicas e a Gays (27 itens) e um Questionário de Conhecimento quanto à Homossexualidade (17 itens). Na análise dos dados foram utilizados estatística descritiva, ANOVAs, testes Chi quadrado e correlações de Pearson. Resultados: A análise incluiu 489 respostas. Os estudantes que se identificaram como sendo do género masculino, mais religiosos e com menos amigos lésbicas, gays ou bissexuais revelaram atitudes mais negativas em relação à homossexualidade. Anos mais avançados no curso ou maior contacto com pacientes lésbicas, gays ou bissexuais não se correlacionaram com as atitudes avaliadas. Apesar da progressão no curso se ter correlacionado significativamente com níveis mais elevados de conhecimento, os itens relacionados com saúde lésbicas, gays ou bissexuais apresentaram menor percentagem de respostas corretas. Conclusão: As atitudes dos estudantes de medicina face a lésbicas e gays parecem ser pouco exploradas ao longo do curso de medicina, havendo também falta de conhecimento sobre as necessidades específicas de saúde das pessoas lésbicas, gays ou bissexuais. Este estudo destaca assim a importância do desenvolvimento de um currículo médico inclusivo, crucial na promoção da qualidade dos cuidados de saúde.

  17. [Vitamin D Insufficiency in a Hospital Population: A Photograph from the Laboratory Perspective].

    PubMed

    Santos, Maria Joana; Fernandes, Vera; Garcia, Fernando Mota

    2015-01-01

    Introdução: Apesar da hipovitaminose D ser cada vez mais reconhecida em todo o mundo, existem poucos estudos sobre a realidade portuguesa. Este trabalho pretende analisar o nível de vitamina D nos doseamentos realizados no nosso hospital e sua relação com idade, sexo, especialidade requisitante e momento da colheita. Material e Métodos: Estudo observacional dos doseamentos de 25(OH)D realizados no nosso Hospital entre junho de 2012 e novembro de 2014. Variáveis estudadas: sexo, idade, especialidade requisitante, mês de colheita. O status de vitamina D foi classificado como: 'Deficiência' (≤ 20 ng/mL), 'Insuficiência' (21 ' 29 ng/mL) e 'Suficiência' (≥ 30 ng/mL). Resultados: Incluímos 5 439 doseamentos; 55,0% pertenciam a mulheres; a idade mediana foi 64,0 anos. Sessenta por cento apresentavam 'Deficiência', 20,7% 'Insuficiência' e 18,9% 'Suficiência'. Encontrámos uma correlação negativa entre idade e nível de vitamina D (p < 0,001), não havendo diferenças significativas entre sexos. Nove especialidades requisitaram 98% dos doseamentos, destacando-se a Nefrologia (56,2%). Encontrámos diferenças entre especialidades requisitantes relativamente à idade e nível de vitamina D (p < 0,001). O nível de vitamina D variou ao longo do ano, com níveis superiores no verão, seguido do outono, primavera e inverno (p < 0,001). Apesar desta variação sazonal, a suficiência de vitamina D foi sempre minoritária, sendo de 27,8% no Verão e 9,2% no Inverno. Discussão: A carência de vitamina D nesta população é elevada, transversal a todas as idades e não compensada pela variação sazonal da exposição solar.Conclusão: A hipovitaminose D é um problema real, prevalente e merecedor de atuação na nossa população, atendendo às suas implicações clínicas.

  18. Hansen Neuropathy: Still a Possible Diagnosis in the Investigation of a Peripheral Neuropathy.

    PubMed

    Veiga, Andreia; Costa, Alexandre; Taipa, Ricardo; Guimarães, António; Pires, Manuel Melo

    2015-01-01

    Introdução: A lepra continua a ser uma das causas mais frequentes de neuropatia periférica. Apesar de tida como erradicada em Portugal, ainda se documenta no estudo neuropatológico de doentes com clínica de neuropatia periférica sem diagnóstico etiológico definido.Material e Métodos: Revisão dos casos neuropatia por doença de Hansen diagnosticados na Unidade de Neuropatologia do Centro Hospitalar do Porto no período de 1978 e 2013 atendendo ao género, idade, manifestações clínicas e achados neuropatológicos.Resultados: Foram identificados 21 doentes com diagnóstico neuropatológico de neuropatia por doença de Hansen, com predomínio do sexo masculino. A idade média ao diagnóstico foi de 52 anos, sendo a sintomatologia sensitiva predominante. O intervalo entre sintomatologia e diagnóstico oscilou entre 1 a 38 anos. Na maioria foi identificada forma tuberculoide em biópsia de nervo e detetados bacilos em pele e nervo em 44% dos casos.Discussão: A mononeurite é a forma mais comum de apresentação de hanseníase, podendo cursar com outras manifestações clínicas incluindo lesões cutâneas. A infeção pelo M. leprae lesiona fibras mielinizadas e não mielinizadas, com substituição do tecido nervoso por colagénio resultando em fibrose. O diagnóstico da lepra é apenas conseguido por estudo neuropatológico das lesões cutâneas e/ou nervo periférico, adjuvado pela identificação do bacilo.Conclusão: A doença de Hansen continua a ser um problema de saúde pública em áreas tropicais e, apesar de rara, ainda descrita em países ocidentais, devendo ser considerada como uma hipótese de diagnóstico na investigação de neuropatia periférica.

  19. [Career Satisfaction of Medical Residents in Portugal].

    PubMed

    Martins, Maria João; Laíns, Inês; Brochado, Bruno; Oliveira-Santos, Manuel; Teixeira, Pedro Pinto; Brandão, Mariana; Cerqueira, Rui João; Castro-Ferreira, Ricardo; Bernardes, Carlos; Menezes, Miguel Nobre; Baptista, Bernardo Soares; Ladeiras-Lopes, Ricardo; Rei, Mariana Cruz; Rosa, Gilberto Pires da; Martins, José Luís; Mendonça Sanches, Maria; Ferreira-Pinto, Manuel J; Rato, Margarida; Costa e Silva, Miguel; Policiano, Catarina; Beato, João; Barbosa-Breda, João; Torres, João Pimentel; Leal, Inês; Rosa, Sílvia Aguiar; Ribeiro, Bárbara Carvalho; Costa, Francisco Rego; Palmela, Carolina; Gonçalves, Tiago Cúrdia; Morais, Luis; Marques, Tiago Reis

    2015-01-01

    Introdução: A satisfação com a profissão médica tem sido apontada como um fator essencial para a qualidade assistencial, o bemestar dos doentes e a estabilidade dos sistemas de saúde. Estudos recentes têm vindo a enfatizar um crescente descontentamento dos médicos, principalmente como consequência das alterações das relações laborais.Objetivos: Avaliar a perceção dos médicos de formação específica em Portugal, sobre as expectativas e grau de satisfação com a profissão, especialidade e local de formação; razões da insatisfação e intenção de emigrar.Material e Métodos: Estudo transversal. A colheita de dados foi efetuada entre Maio e Agosto de 2014 através de um Inquérito online sobre a âÄúSatisfação com a EspecialidadeâÄù.Resultados: De uma população total de 5788 médicos, foram obtidas 804 respostas (12,25% do total de médicos internos). Desta amostra, 77% das respostas correspondem a internos dos três primeiros anos de formação. Verificou-se que 90% dos médicos se encontram satisfeitos com a especialidade, tendo-se encontrado também níveis elevados de satisfação com a profissão (85%) e local de formação (86%). Por outro lado, constatou-se que estes diminuíam com a progressão ao longo dos anos de internato. A avaliação global sobre o panorama da prática médica foi negativa e 65% dos médicos responderam que consideram emigrar após conclusão do internato.Conclusão: Os médicos internos em Portugal apresentam níveis positivos de satisfação com a sua profissão. No entanto, a sua opinião sobre o panorama da Medicina e os resultados relativos à intenção de emigrar alertam para a necessidade de tomada de medidas para inverter este cenário.

  20. [Gestational diabetes and the new screening test's impact].

    PubMed

    Massa, Ana Catarina; Rangel, Ricardo; Cardoso, Manuela; Campos, Ana

    2015-01-01

    Introdução: Em 2011, foi introduzido um novo rastreio para a diabetes gestacional que permitiu um diagnóstico mais precoce e de maior número de casos com o intuito de reduzir complicações maternas e perinatais. O objectivo deste estudo foi avaliar a prevalência da diabetes gestacional, comparar resultados obstétricos e perinatais do anterior e presente rastreio e os resultados e realização da prova de reclassificação pós-parto. Material e Métodos: Estudo retrospectivo em gestações simples e diabetes gestacional diagnosticados em 2009 (n = 223) e 2012 (n = 237), vigiadas na Maternidade Dr. Alfredo da Costa, Portugal. Após consulta de processos clínicos procedeu-se à análise de características demográficas, história médica e obstétrica, aumento ponderal durante a gravidez, idade gestacional do diagnóstico, terapêutica utilizada, resultados perinatais e reclassificação pós-parto, seguida de comparação destas variáveis entre os anos de 2009 e 2012. Resultados: Em 2012, houve maior prevalência de diabetes gestacional, ganho ponderal inferior (p < 0,001), maior recurso à terapêutica farmacológica (p < 0,001) e aumento dos casos diagnosticados no primeiro e segundo trimestres (p < 0,001). Relativamente aos resultados neonatais, o peso médio do recém-nascido ao nascer foi significativamente menor (p = 0,001) com diminuição dos recém-nascidos grandes para a idade gestacional (p = 0,002). A taxa de reclassificação pós-parto foi semelhante nos dois anos mas em 2012 houve um aumento dos resultados normais e diminuição das anomalias da glicémia em jejum. Discussão: Critérios mais apertados do actual rastreio permitiram a redução da maioria das complicações da diabetes gestacional levantando novas questões. Conclusão: A introdução do actual rastreio resultou num aumento de prevalência, diagnóstico mais precoce e redução da macrossomia.

  1. Variação temporal do gradiente radial de o/h a partir de uma amostra de nebulosas planetárias

    NASA Astrophysics Data System (ADS)

    Maciel, W. J.; Costa, R. D. D.; Uchida, M. M. M.

    2003-08-01

    Gradientes radiais de abundância são observados no disco de nossa Galáxia e também em outras galáxias espirais. No caso da Galáxia, o principal problema relativo aos gradientes é sua variação temporal, que constitui um dos principais vínculos aos modelos de evolução química da Galáxia. As nebulosas planetárias são particularmente interessantes no estudo dos gradientes e suas variações, tanto espaciais como temporais. São objetos brilhantes, podendo ser observadas a grandes distâncias, e têm abundâncias relativamente precisas de diversos elementos químicos. Além disso, sendo originadas de estrelas com massas entre 0.8 e 8 massas solares na sequência principal, incluem objetos com idades e populações diferentes, o que as torna especialmente interessantes ao estudo da variação temporal dos gradientes. Neste trabalho, apresentamos resultados recentes sobre a variação temporal do gradiente de O/H a partir de uma amostra contendo cerca de 200 nebulosas, para as quais obtivemos distâncias por métodos estatísticos. As abundâncias foram parcialmente obtidas a partir de observações em Itajubá e La Silla, sendo as restantes obtidas da literatura. Os resultados mostram, pela primeira vez, evidências de um achatamento do gradiente de O/H, de -0.11 dex/kpc para -0.06 dex/kpc nos últimos 9 giga-anos ou de -0.08 dex/kpc para -0.06 dex/kpc nos últimos 5 giga-anos. Esses valores apresentam um bom acordo com alguns modelos recentes para a evolução química da Galáxia. (FAPESP/CNPq)

  2. Oral health in the agenda of priorities in public health.

    PubMed

    Antunes, José Leopoldo Ferreira; Toporcov, Tatiana Natasha; Bastos, João Luiz; Frazão, Paulo; Narvai, Paulo Capel; Peres, Marco Aurélio

    2016-09-01

    This study describes the scientific production on oral health diffused in Revista de Saúde Pública, in the 50 years of its publication. A narrative review study was carried out using PubMed, as it is the search database that indexes all issues of the journal. From 1967 to 2015, 162 manuscripts specifically focused on oral health themes were published. This theme was present in all volumes of the journal, with increasing participation over the years. Dental caries was the most studied theme, constantly present in the journal since its first issue. Periodontal disease, fluorosis, malocclusions, and other themes emerged even before the decline of dental caries indicators. Oral health policy is the most recurring theme in the last two decades. Revista de Saúde Pública has been an important vehicle for dissemination, communication, and reflection on oral health, contributing in a relevant way to the technical-scientific interaction between professionals in this field. RESUMO Este estudo descreve a produção científica sobre saúde bucal veiculada na Revista de Saúde Pública, nos cinquenta anos de sua publicação. Foi realizado estudo de revisão narrativa, utilizando o PubMed como mecanismo de busca que indexa todos os fascículos da revista. De 1967 a 2015, foram publicados 162 manuscritos com foco específico em temas de saúde bucal. Essa temática esteve presente em todos os volumes da revista, com participação crescente ao longo dos anos. Cárie dentária foi o tema mais estudado, marcando presença constante na revista desde seu primeiro fascículo. Doença periodontal, fluorose, oclusopatias e outros temas emergiram antes mesmo do declínio dos indicadores de cárie. Políticas de saúde bucal é o tema mais recorrente nas duas últimas décadas. A Revista de Saúde Pública tem sido importante veículo de divulgação, comunicação e reflexão sobre saúde bucal, contribuindo de modo relevante para a interação técnico-científica entre os

  3. Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Polycystic Ovary Syndrome.

    PubMed

    Luz, Rita; Barros, Joana; Aguiar, Ana; Rodrigues, Cátia; Soares, Ana Paula; Nunes, Joaquim; Sousa, Sandra; Calhaz-Jorge, Carlos

    2016-08-01

    Introdução: A síndrome dos ovários poliquísticos é a causa mais frequente de anovulação e o tratamento envolve uma abordagem faseada. A electrocoagulação laparoscópica dos ovários é aceite como segunda linha no tratamento das doentes que não respondem ao citrato de clomifeno. Os objectivos deste estudo foram determinar a eficácia desta técnica a curto e longo prazo e definir os factores preditivos de gravidez espontânea. Material e Métodos: Este estudo retrospectivo envolveu 76 mulheres submetidas a electrocoagulação dos ovários entre 2004 e 2013, num hospital universitário. Os desfechos principais foram a regularidade menstrual e gravidez. Os resultados a curto prazo registados durante a vigilância na unidade foram revistos e os desfechos a longo prazo foram avaliados através de entrevista telefónica realizada a todas as mulheres operadas há mais de três anos. Dados clínicos e bioquímicos foram analisados como factores preditivos de gravidez espontânea em doentes sem outros factores de infertilidade. Resultados: A regularidade do ciclo menstrual foi alcançada inicialmente em 53 (70%) mulheres e a longo prazo, 52% (12/53) tinham ciclos regulares. Em geral, 53 (70%) mulheres engravidaram e foram obtidas 77 gravidezes, 60% das quais foram espontâneas. O único factor de prognóstico associado a gravidez espontânea foi a duração da infertilidade inferior a três anos (p < 0,05). Discussão: A electrocoagulação dos ovários demonstrou taxas de gravidez comparáveis a outros tratamentos de indução da ovulação com a vantagem de ter efeitos benéficos duradouros na regularidade menstrual e fertilidade. Conclusão: A electrocoagulação dos ovários é uma opção de tratamento segura e eficaz na infertilidade anovulatória em mulheres com síndrome dos ovários poliquísticos.

  4. [The Importance of Early Referral in Pediatric Acute Liver Failure].

    PubMed

    Jerónimo, Mónica; Moinho, Rita; Pinto, Carla; Carvalho, Leonor; Gonçalves, Isabel; Furtado, Emanuel; Farela Neves, José

    2015-01-01

    Introdução: A falência hepática aguda é uma doença rara associada a elevada morbilidade e mortalidade apesar do aumento da sobrevida devido ao transplante hepático. Em 2008, decorreu em Portugal uma reunião sobre esta patologia em pediatria, resultando num consenso de atuação que salientou a importância da abordagem multidisciplinar e referenciação precoce para um centro de transplantação hepática. Objetivos: Caracterizar as admissões por falência hepática aguda no Serviço de Cuidados Intensivos Pediátricos do centro português com transplante hepático pediátrico. Comparar resultados antes (A) e depois de 2008 (B). Material e Métodos: Estudo observacional retrospetivo de 20 anos (1994-2014). Critérios de inclusão: idade < 18 anos e falência hepática aguda (INR ≥ 2 sem resposta à vitamina K e necrose hepatocelular). Excluíram-se as crianças com doença hepática crónica. Resultados: Incluíram-se 50 crianças com idade mediana de 24,5 meses. A causa mais comum de falência hepática aguda abaixo dos 2 anos foi metabólica (34,6%) e acima infeciosa (29,2%). Foram submetidos a transplante hepático 46%, tendo sobrevivido 78%. A mortalidade global foi 34%. A mediana do tempo de referenciação foi 7 dias no período A (n = 35) e 2 no B (n = 15; p = 0,006). A mediana do risco de mortalidade prevista pelo PRISM foi 14,7% no período A e 6,5% no B (p = 0,019). A mortalidade foi 37% vs 26% no período A e B respetivamente (p = 0,474).Discussão e Conclusões: A mortalidade global foi sobreponível à de outros centros europeus, sendo o transplante hepático a opção terapêutica mais eficaz. Após 2008 o tempo de referenciação e a gravidade dos casos na admissão reduziram, ainda sem tradução significativa na mortalidade.

  5. [Hypertension Control at the Primary Health Care: A Comparison Among Portuguese Natives and Portuguese Speaking African Coutries Immigrants].

    PubMed

    Lopes, Elisa; Alarcão, Violeta; Simões, Rui; Fernandes, Milene; Gómez, Verónica; Souto, Diana; Nogueira, Paulo; J Nicola, Paulo J; Rocha, Evangelista

    2016-03-01

    Introdução: Em Portugal, a percentagem de hipertensos tratados e controlados é relativamente baixa. Desconhece-se a relação dos determinantes socioeconómicos com o controlo tensional, particularmente nos imigrantes africanos. Objetivo: Comparar a frequência de controlo nos hipertensos tratados e identificar características associadas à hipertensão tratada não controlada, entre nativos portugueses (caucasianos) e imigrantes dos PALOP (negros). Material e Métodos: Estudo transversal de hipertensos tratados, com 40-80 anos, aleatorizados dos Cuidados de Saúde Primários da região de Lisboa. Recolheram-se dados sociodemográficos, clínicos e cuidados de saúde por entrevistas estruturadas. Comparou-se a frequência de hipertensos não controlados nos dois grupos, identificando-se fatores relacionados por análise univariada e multi-variada. Resultados: Participaram 786 hipertensos tratados (taxa de participação: 71%): 449 nativos e 337 imigrantes. Destes, 46% tinham a hipertensão controlada. A pressão arterial diastólica foi mais elevada nos imigrantes mais novos. Nos nativos, o não controlo associou--se a: sexo masculino, menor grau de escolaridade, ida aos serviços de urgência e/ou enfermagem e não ida ao médico de família; nos imigrantes, ser solteiro, recorrer ao farmacêutico, número de anos de doença e não adesão intencional à terapêutica. Discussão: O controlo da hipertensão tratada tem vindo a aumentar nos últimos anos. Nativos e imigrantes diferenciam-se no controlo tensional relativamente à frequência do recurso a consulta do médico de família, e de outros serviços e profissionais de saúde. Estas diferenças não se refletiram em taxas de controlo estatisticamente significativas. Conclusões: Será necessário definir estratégias para o controlo da hipertensão nos cuidados de saúde primários diferenciadas para os grupos étnicos.

  6. [Study of the Sociodemographic Factors and Risky Behaviours Associated with the Acquisition of Sexual Transmitted Infections by Foreign Exchange Students in Portugal].

    PubMed

    Gravata, Andreia; Castro, Rita; Borges-Costa, João

    2016-06-01

    Introdução: As infeções sexualmente transmissíveis são um problema de saúde pública, sendo mais frequentes em jovens. Este estudo teve como principal objetivo avaliar os fatores sociodemográficos e comportamentos associados à aquisição de infeções sexualmente transmissíveis e o conhecimento sobre infeção por Chlamydia trachomatis em estudantes estrangeiros em intercâmbio universitário em Portugal. Material e Métodos: Os fatores sociodemográficos e comportamentos de risco foram estudados por aplicação de um questionário a estudantes em intercâmbio universitário em Portugal, inscritos nos anos letivos de 2012/2013, 2013/2014 e 2014/2015. Resultados: Avaliaram-se 338 questionários: 58,3% participantes do sexo feminino e 40,8% do sexo masculino (17 aos 30 anos). A idade média apontada para o início da vida sexual foi de 17,5 anos e a média de parceiros sexuais de 6,9. Relativamente às questões inquiridas foi referido: 9,5% negaram atividade sexual oral; 29% com atividade sexual anal; 11,8% com atividade sexual com parceiros do mesmo género; 82,1% refere consumo de álcool/estupefacientes; 42,3% desconhecimento sobre a infeção por Chlamydia trachomatis e 21% sobre o risco de transmissão de infeção por via oral. Discussão: Apesar das infeções sexualmente transmissíveis poderem afetar indivíduos de todas as idades, raças e orientações sexuais, vários fatores demográficos, sociais e comportamentais têm revelado influência nas taxas de prevalência deste tipo de infeções.Conclusões: Nesta população os fatores de risco associados a uma maior prevalência de infeções sexualmente transmissíveis continuam a existir, nomeadamente início precoce da atividade sexual, parceiros sexuais múltiplos e ausência de medidas de proteção durante as relações sexuais.

  7. Uso de modelos mecânicos em curso informal de astronomia para deficientes visuais. Resgate de uma experiência

    NASA Astrophysics Data System (ADS)

    Tavares, E. T., Jr.; Klafke, J. C.

    2003-08-01

    O presente trabalho propõe-se a resgatar uma experiência que teve lugar no Planetário de São Paulo nos anos 60. Em 1962, o Sr. Acácio, então com 37 anos, deficiente visual desde os 27, passou a assistir às aulas ministradas pelo Prof. Aristóteles Orsini aos integrantes do corpo de servidores do Planetário. O Sr. Acácio era o único deficiente da turma e, embora possuísse conhecimentos básicos e relativamente avançados de matemática, enfrentava dificuldades na compreensão e acompanhamento da exposição, como também em estudos posteriores. Com o intuito de auxiliá-lo na superação desses problemas, o Prof. Orsini solicitou a construção de modelos mecânicos que, através do sentido do tato, permitissem o acompanhamento das aulas e a transposição do modelo para o "constructo" mental. Essa prática mostrou-se tão eficaz que facilitou sobejamente o aprendizado da matéria pelo sujeito. O Sr. Acácio passou a integrar o corpo de professores do Planetário/Escola Municipal de Astrofísica, tendo ficado responsável pelo curso de "Introdução à Astronomia" por vários anos. Além disso, a experiência foi tão bem sucedida que alguns dos modelos tiveram seus elementos constitutivos pintados diferencialmente para serem utilizados em cursos regulares do Planetário, tornando-se parte integrante do conjunto de recursos didáticos da instituição. É pensando nessa eficácia, tanto em seu objetivo original permitir o aprendizado de um deficiente visual quanto no subsidiário recurso didático sistemático da instituição que decidimos resgatar essa experiência. Estribados nela, acreditamos ser extremamente produtivo, em termos educacionais, o aperfeiçoamento dos modelos originais, agora resgatados e restaurados, e a criação de outros que pudessem ser utilizados no ensino dessa ciência a deficientes visuais.

  8. [Surgical Treated Spondylodiscitis Epidemiological Study].

    PubMed

    Soares do Brito, Joaquim; Tirado, António; Fernandes, Pedro

    2016-05-01

    Introdução: O termo espondilodiscite descreve uma qualquer infeção da coluna vertebral, sendo o tratamento gold standard baseado na terapêutica médica e a indicação cirúrgica ponderada em casos particulares. Foi objetivo deste trabalho estudar o perfil epide-miológico de um grupo de doentes com espondilodiscite submetidos a tratamento cirúrgico numa mesma instituição nacional entre 1997 e 2013. Material e Métodos: Análise epidemiológica de 85 doentes com diagnóstico de espondilodiscite submetidos a tratamento cirúrgico. Foram analisados os processos clínicos, estudos de imagem e registos informáticos. Resultados: Foram tratados 51 doentes do género masculino e 34 do género feminino. A idade média foi de 48 anos (min: 6 - máx: 80). O segmento lombar foi o mais afetado e o Mycobacterium tuberculosis o agente etiológico mais frequente. A distribuição do número de casos ao longo dos anos manteve-se aproximadamente constante, com discreto aumento da incidência do Staphylococus aureus e diminuição do número de casos sem agente identificado. Trinta e nove doentes apresentavam abcesso paravertebral e 17 lesão neurológica concomitante, a maioria no segmento torácico e em relação com infeção tuberculosa. Dez doentes apresentavam imunodepressão importante. Discussão: Nesta série verificou-se um predomínio da infeção tuberculosa, no género masculino e em indivíduos jovens. Enquanto o número de casos/ano das discites tuberculosas se mantém constante, as infeções a Staphylococus aureus parecem ganhar preponderância. O abcesso paravertebral e a lesão neurológica constituíram uma complicação frequente da infeção tuberculosa. Conclusão: As infeções da coluna vertebral com necessidade cirúrgica persistem como patologia relevante. Mycobacterium tuberculosis e Staphylococcus aureus representam os principais agentes etiológicos, parecendo existir uma incidência crescente deste último agente.

  9. [Hypofractionation in locally advanced breast cancer: "flash" scheme].

    PubMed

    Padilha, Marisa; Gonçalves, Sara; Fardilha, Carlos; Melo, Gilberto; Miranda, Cristina; Alves, Paula

    2013-01-01

    Introdução: O carcinoma da mama é uma das principais causas de morte no nosso país. No Serviço de Radioterapia do Instituto Português de Oncologia de Coimbra de Coimbra utilizamos, desde há mais de 30 anos, um esquema de hipofraccionamento de radioterapia, denominado “Flash”, como opção terapêutica em doentes idosos ou com baixo Performance Status, portadores de carcinoma da mama localmente avançado ou com estádios IIb ou IV, com intenção neoadjuvante ou paliativa. Objectivos: Avaliar a resposta ao tratamento, nomeadamente sobrevivência global aos três anos, resposta local e toxicidades aguda e crónica, no grupo de doentes seleccionados submetidos a esquema de hipofraccionamento, em estudo retrospectivo. Metodologia: Entre Janeiro de 2006 e Dezembro de 2008, um total de 83 doentes com diagnóstico de Carcinoma da Mama Localmente Avançado ou com estádios IIb ou IV, foi submetido a “Flash” mamário. A dose de radioterapia prescrita foi de 13Gy / 2Fr / 3 dias (em 23 doentes - 27,7%) e 26Gy / 4Fr / 2,5 semanas (em 60 doentes - 72,3%), com fotões de 4 MV, sobre a mama afectada. Foi avaliada sobrevivência global segundo o método de Kaplan-Meier. A análise estatística foi efectuada através da aplicação SPSS, versão 17.0 e os testes estatísticos foram avaliados ao nível de significância de 5%. Resultados: 80 doentes (96,4%) que efectuaram “Flash” mamário eram do género feminino, com idades compreendidas entre os 59 e os 93 anos (idade média 80,72 + 5,87 anos) e Performance Status (Karnosfsky: 0 - 100) entre 90 e 50%. Em 72 doentes (86,7%) o diagnóstico histológico foi Carcinoma Ductal Invasivo. A cirurgia após a realização do “Flash” Mamário foi realizada em 44 doentes (53%) após evidência de resposta local à radioterapia, sendo a Mastectomia Radical Modificada a técnica cirúrgica mais frequente. Efectuou-se o diagnóstico de metastização óssea em 10 doentes (12%), sendo que a taxa de sobrevivência global foi

  10. ...And That's How It All Began: Putting Information about Your Child's Growth, Health and Safety All within Your Reach...Because the First Years Last Forever! = ...Y asi es como empezo todo: Ponemos a su alcance en forma conjunta la informacion sobre el crecimiento, la salud y la seguridad de su hijo...Porque los primeros anos duran para siempre!

    ERIC Educational Resources Information Center

    North Carolina Partnership for Children, Raleigh.

    Smart Start is North Carolina's model early childhood initiative to help all North Carolina children enter school healthy and prepared for success. This resource guide, in Spanish and English versions, is designed to provide parents with information on infant and child development, health care, and resources for further assistance. Presented in an…

  11. Talking, Singing, Rhyming: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Hablar, cantar, recitar: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  12. Exploring with Technology: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Exploremos con tecnologia: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides computer literacy…

  13. Reading with Children: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = La lectura con los ninos: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  14. Words All around Us: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Palabras y palabras a nuestro alrededor: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  15. En sus marcas--Listos--A leer! Para los cuidadores de ninos pequenos: Actividades de lenguaje para la primera infancia y ninez entre el nacimiento y los 5 anos. El reto: A leer, America! (Ready--Set--Read! For Caregivers: Early Childhood Language Activities for Children from Birth through Age Five. America Reads Challenge).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This Ready--Set--Read Kit includes an activity guide for caregivers, a 1997-98 early childhood activity calendar, and an early childhood growth chart. The activity guide presents activities and ideas that caregivers (family child care providers and the teachers, staff, and volunteers in child development programs) can use to help young children…

  16. Algunas Premisas Metodologicas y Conceptuales sobre el Desarrollo de los Movimientos en el Primer Ano de Vida (0-12 Meses) (Some Methodological and Conceptual Premises about the Development of Movement in the First Year of Life (0-12 Months)).

    ERIC Educational Resources Information Center

    Bequer Diaz, Gladys

    1997-01-01

    Examined the emergence of principal and secondary movements in Cuban children in their first year of life. Based on 35 examples of observed movements, an integrated program of activity is developed to assist in the development of physical skills which are essential to the development of a well-rounded personality. (AS)

  17. A Visit to the Library: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Una visita a la biblioteca: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides suggestions for parents…

  18. O Passado como Nacao: Imagens do Imperio nas Falas Reacionarias dos Anos 30 e 40 do Seculo XX: Uma Pequena Arqueologia do Debate Publico e Privado (The Past as Nation: Images of the Empire in the Reactionary Words of the 30s and 40s in the 20th Century: A Small Archaeology of the Public Debate versus the Private One).

    ERIC Educational Resources Information Center

    de Freitas, Marcos Cezar

    1998-01-01

    Suggests an archaeology of the public debate versus the private one in Brazil through analysis of the reactionary speech of a religious leader, Dom Jose Mauricio da Rocha, which produced innumerable representations of the Brazilian Empire. (PA)

  19. El juego entre el nacimiento y los 7 anos: Un manual para ludotecarias. Investigacion-accion sobre la Familia y la Primera Infancia. UNESCO Sector de Educacion Monografia (Play between Birth and 7 Years: A Manual for Preschool Teachers. Action Research in Family and Early Childhood. UNESCO Education Sector Monograph).

    ERIC Educational Resources Information Center

    Grellet, Carolina

    The purpose of this Spanish-language manual is to help preschool teachers better understand theoretical concepts related to children's play. Following a preface that discusses UNESCO's activities related to early childhood education, the two main sections of the manual discuss children's play between 0-2 years and 2-7 years. Each section includes…

  20. Art and Writing: Activities for Families with Children Ages 3 to 5 [Presented by]"Between the Lions[R]" = Arte y escritura: Actividades para familias con ninos de 3 a 5 anos [presentado por]"Between the Lions[R]."

    ERIC Educational Resources Information Center

    WGBH-TV, Boston, MA.

    "Between the Lions" is a Public Broadcasting System program promoting literacy for children ages 4 through 7 years combining state-of-the-art puppetry, animation, live action, and music to achieve its mission of helping young children learn to read. This guide, in English- and Spanish-language versions, provides literacy activities for…

  1. En sus marcas--Listos--A leer! Para las familias: Actividades de lenguaje para la primera infancia y ninez entre el nacimiento y los 5 anos. El reto: A leer, America! (Ready--Set--Read! For Families: Early Childhood Language Activities for Children from Birth through Age Five. America Reads Challenge).

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This Ready--Set--Read Kit includes an activity guide for families, a 1997-98 early childhood activity calendar, and an early childhood growth wallchart. The activity guide presents activities and ideas that families (adults who have nurturing relationships with a child--a mother, father, grandparent, other relative, or close friend) can use to…

  2. A Guide for Parents and Families about What Your 11th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Grado 11 Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  3. Reading: Students' Attitudes and Interests in Fourth, Fifth, and Sixth Grades in Official Portuguese Schools in the USA (A Leitura: Atitudes e Preferencias dos Educandos do 4th, 5th, e 6th Anos de Escolaridade nas Escolas Oficiais Portuguesas nos Estados Unidos da America).

    ERIC Educational Resources Information Center

    Castanho, Maria da Graca Borges

    A study investigated attitudes and preferences concerning reading among fourth-, fifth-, and sixth-grade students in Portuguese-language schools in the United States. Extrinsic factors influencing students (parents, teachers) were also analyzed. The research took place in 10 schools in 5 states. Data were obtained using questionnaires (students)…

  4. A Guide for Parents and Families about What Your 5th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 5to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  5. A Guide for Parents and Families about What Your 8th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Octavo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  6. A Guide for Parents and Families about What Your 7th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Septimo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  7. A Guide for Parents and Families about What Your 2nd Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 2do Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  8. A Guide for Parents and Families about What Your 3rd Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 3er Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  9. A Guide for Parents and Families about What Your 10th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Decimo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Education Oversight Committee, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  10. A Guide for Parents and Families about What Your 4th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 4to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  11. A Guide for Parents and Families about What Your 6th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 6to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  12. A Guide for Parents and Families about What Your 1st Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 1er Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  13. A Guide for Parents and Families about What Your 9th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Noveno Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  14. A Guide for Parents and Families about What Your Kindergartner Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Jardin Infantil (Kindergarten) Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  15. A Guide for Parents and Families about What Your 12th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Grado 12 Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Education Oversight Committee, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  16. Insider Threats in the Software Development Lifecycle

    DTIC Science & Technology

    2014-11-05

    organization sanctions O O O Addiction to Financial Gain Initial Satisfaction S S S Financial Needs increasing financial need decreasing financial...including mobile devices. Beginning with the hiring process, monitor and respond to suspicious or disruptive behavior. Develop a comprehensive...Relations Email: info@sei.cmu.edu Telephone: +1 412-268-5800 SEI Phone : +1 412-268-5800 SEI Fax: +1 412-268-6257

  17. The CERT Approach to Cybersecurity Workforce Development

    DTIC Science & Technology

    2010-12-01

    CMU/SEI-2010-TR-045 | i Table of Contents Executive Summary iii Abstract v 1 Shortcomings with the Traditional Classroom Training Model 1 2 A New...workforce development. CMU/SEI-2010-TR-045 | vi CMU/SEI-2010-TR-045 | 1 1 Shortcomings with the Traditional Classroom Training Model The...most common workforce development training solution is the traditional classroom training model. While this training model is easy to implement and is

  18. Total Ownership Cost a Decade Into the 21st Century

    DTIC Science & Technology

    2012-09-30

    network—overloading the total bandwidth available for all systems. In addition, members of the Software Engineering Institute ( SEI ; Morris, Levine...Engineering Institute’s ( SEI ) Quality Attribute Workshop (QAW) The QAW is designed to help identify a complete (or as complete as possible...vastly improve the accuracy of system TOC projections. While improving system requirements development, the QAW is designed to work with another SEI

  19. Assurance Cases for Medical Devices

    DTIC Science & Technology

    2011-04-28

    SEI’s  Research,  Technology,  and  System   Solu2ons  program.  With  his  colleague  John   Goodenough ,  Weinstock...contact The SEI and Medical Devices *Charles B. Weinstock and John B. Goodenough , Towards an Assurance Case Practice for Medical Devices, CMU/SEI-2009-TN

  20. Software Assurance vs. Security Compliance: Why is Compliance Not Enough

    DTIC Science & Technology

    2012-04-26

    Goodenough , Charles Weinstock, & Carol Woody. (CMU/SEI-2008-TR- 008), May 2008. http://www.sei.cmu.edu/library/abstracts/reports/08tr008.cfm 24 Supply...Supply Chain Resources Software Supply Chain Risk Management: From Products to Systems of Systems, Robert J. Ellison, John B. Goodenough , Charles B...Software Supply Chain Security Risks, Robert J. Ellison, , John B. Goodenough , Charles B. Weinstock, & Carol Woody. (CMU/SEI-2010-TN-016), May 2010

  1. Team Software Process (TSP) Coach Mentoring Program Guidebook Version 1.1

    DTIC Science & Technology

    2010-06-01

    complete C NO YES Document how the provisional coach performed in comparison to the DACUM Mentoring artifacts, to be submitted to the SEI during...016 Appendix B TSP Coach Job Analysis Report B-2 | CMU/SEI-2010-SR-016 B-3 | CMU/SEI-2010-SR-016 DACUM Research Chart for Team Software...ProcessSM (TSPSM) Coach DACUM Panel Dan Burton Software Engineering Institute Robert Cannon Software Engineering Institute Noopur

  2. Mapping a Domain Model and Architecture to a Generic Design

    DTIC Science & Technology

    1994-05-01

    software engineering life cycle entitled Mode/-Based Software Engineerng ( MBSE ), a concept first described by the SEI In [Feller 93]. MBSE enables...organizations to build software applications which must evolve with a minimum of rework and scrap to meet changes in mission and technology. MBSE Involves...software models are also built. MBSE is a focus area for the SEI’s Engineering Techniques Program and is the subjedt of a recent SEI report [Withey 94

  3. Tuning the Solid Electrolyte Interphase for Selective Li- and Na-Ion Storage in Hard Carbon.

    PubMed

    Soto, Fernando A; Yan, Pengfei; Engelhard, Mark H; Marzouk, Asma; Wang, Chongmin; Xu, Guiliang; Chen, Zonghai; Amine, Khalil; Liu, Jun; Sprenkle, Vincent L; El-Mellouhi, Fedwa; Balbuena, Perla B; Li, Xiaolin

    2017-03-07

    Solid-electrolyte interphase (SEI) films with controllable properties are highly desirable for improving battery performance. In this paper, a combined experimental and theoretical approach is used to study SEI films formed on hard carbon in Li- and Na-ion batteries. It is shown that a stable SEI layer can be designed by precycling an electrode in a desired Li- or Na-based electrolyte, and that ionic transport can be kinetically controlled. Selective Li- and Na-based SEI membranes are produced using Li- or Na-based electrolytes, respectively. The Na-based SEI allows easy transport of Li ions, while the Li-based SEI shuts off Na-ion transport. Na-ion storage can be manipulated by tuning the SEI layer with film-forming electrolyte additives, or by preforming an SEI layer on the electrode surface. The Na specific capacity can be controlled to < 25 mAh g(-1) ; ≈ 1/10 of the normal capacity (250 mAh g(-1) ). Unusual selective/preferential transport of Li ions is demonstrated by preforming an SEI layer on the electrode surface and corroborated with a mixed electrolyte. This work may provide new guidance for preparing good ion-selective conductors using electrochemical approaches.

  4. 77 FR 45592 - Marine Mammals; File No. 17157

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-01

    ... each of blue whale (Balaenoptera musculus), sei whale (B. borealis), minke whale (B. acutorostrata), humpback whale (Megaptera novaeangliae), and gray whale (Eschrichtius robustus) from museums worldwide...

  5. Disordered eating links to body-relevant and body-irrelevant influences on self-evaluation.

    PubMed

    Woodward, Halley E; Rizk, Marianne T; Wang, Shirley S; Treat, Teresa A

    2014-04-01

    We investigated eating- and weight-related correlates of self-evaluation influences (SEIs) and examined the extent to which such SEIs can be both over- and undervalued and the extent to which measurement strategy affects SEIs. A female undergraduate sample (n = 549) completed 3 measures of SEI importance and questionnaires assessing disordered eating (DE), body mass index (BMI), and depression. SEI measures included Likert scale, rank ordering, and pairwise forced choice; a subset (n = 62) also completed the Shape- and Weight-Based Self-Esteem Scale (SAWBS). Only rank ordering, forced choice, and SAWBS constrain choices among SEIs, such that prioritizing one SEI necessarily deprioritizes another, which reflects real-world restrictions on individuals' allotment of time and energy (e.g., spending hours exercising daily necessarily reduces time available for other activities). By any measure, women with DE overvalue body shape and weight. The constraining measures reveal systematic undervaluation of intelligence and achievement among women with DE and an enhanced effect of DE on the overvaluation of weight and on the undervaluation of being a good person among those with higher BMI. Depressed women's self-evaluations overemphasize appearance and underemphasize interpersonal relationships. Self-evaluations of women with DE are marked by both over- and undervaluation of relevant SEIs; the overvaluation of shape and weight in DE may be associated with costs. Future use of constraining measures, such as forced choice or rank ordering, may enhance our understanding of both over- and underemphasized SEIs among women with DE.

  6. Highly Quantitative Electrochemical Characterization of Non-Aqueous Electrolytes & Solid Electrolyte Interphases

    SciTech Connect

    Sergiy V. Sazhin; Kevin L. Gering; Mason K. Harrup; Harry W. Rollins

    2012-10-01

    The methods to measure solid electrolyte interphase (SEI) electrochemical properties and SEI formation capability of non-aqueous electrolyte solutions are not adequately addressed in the literature. And yet, there is a strong demand in new electrolyte generations that promote stabilized SEIs and have an influence to resolve safety, calendar life and other limitations of Li-ion batteries. To fill this gap, in situ electrochemical approach with new descriptive criteria for highly quantitative characterization of SEI and electrolytes is proposed. These criteria are: SEI formation capacity, SEI corrosion rate, SEI maintenance rate, and SEI kinetic stability. These criteria are associated with battery parameters like irreversible capacity, self-discharge, shelf-life, power, etc. Therefore, they are especially useful for electrolyte development and standard fast screening, allowing a skillful approach to narrow down the search for the best electrolyte. The characterization protocol also allows retrieving information on interfacial resistance for SEI layers and the electrochemical window of electrolytes, the other important metrics of characterization. The method validation was done on electrolyte blends containing phosphazenes, developed at Idaho National Laboratory, as 1.2M LiPF6 [80 % EC-MEC (2:8) (v/v) + 20% Phosphazene variety] (v/v), which were targeted for safer electrolyte variations.

  7. A Review of Solid Electrolyte Interphases on Lithium Metal Anode

    PubMed Central

    Cheng, Xin‐Bing; Zhang, Rui; Zhao, Chen‐Zi; Wei, Fei; Zhang, Ji‐Guang

    2015-01-01

    Lithium metal batteries (LMBs) are among the most promising candidates of high‐energy‐density devices for advanced energy storage. However, the growth of dendrites greatly hinders the practical applications of LMBs in portable electronics and electric vehicles. Constructing stable and efficient solid electrolyte interphase (SEI) is among the most effective strategies to inhibit the dendrite growth and thus to achieve a superior cycling performance. In this review, the mechanisms of SEI formation and models of SEI structure are briefly summarized. The analysis methods to probe the surface chemistry, surface morphology, electrochemical property, dynamic characteristics of SEI layer are emphasized. The critical factors affecting the SEI formation, such as electrolyte component, temperature, current density, are comprehensively debated. The efficient methods to modify SEI layer with the introduction of new electrolyte system and additives, ex‐situ‐formed protective layer, as well as electrode design, are summarized. Although these works afford new insights into SEI research, robust and precise routes for SEI modification with well‐designed structure, as well as understanding of the connection between structure and electrochemical performance, is still inadequate. A multidisciplinary approach is highly required to enable the formation of robust SEI for highly efficient energy storage systems. PMID:27774393

  8. 77 FR 1973 - Environmental Impact Statement: In the Vicinity of the City and Borough of Juneau, AK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... provide travel flexibility, capacity to meet demand, and greater travel opportunity while reducing travel... requested. Newspaper notices, newsletters, and Web site postings will explain the SEIS process, describe...

  9. 77 FR 26517 - Marine Mammals; File No. 14118

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ...- and long- finned pilot whales (Globicephala spp.) and endangered humpback (Megaptera novaeangliae) whales. Fin (B. physalus) and sei (B. borealis) whales may be incidentally harassed. ADDRESSES:...

  10. Organizational Considerations for Implementing Systems Engineering and Integration in the Ares Projects Office

    NASA Technical Reports Server (NTRS)

    Thomas, LeAnn; Doreswamy, Rajiv N.

    2008-01-01

    Systems Engineering and Integration (SE&I) is a critical discipline in developing new space systems. In 2005, NASA performed an internal study of 24 agency and Department of Defense (DoD) programs to evaluate methods of integrating SE&I practices and determine their effectiveness. The goal of the study was to determine the best SE&I implementation strategy for the Ares Projects Office. The study identified six SE&I organizational structures: 1. Lead systems integrator (LSI) with SE&I responsibility and government technical insight. 2a. Integration contractor with government SE&I responsibility (government insight). 2b. Integration contractor with government SE&I responsibility (government oversight). 3a. Prime contractor with SE&I responsibility (government insight). 3b. Prime contractor with SE&I responsibility (government oversight). 3c. Prime contractor with SE&I responsibility (government/industry partnership). 4a.Prime contractor with government SE&I responsibility (government insight). 4b. Prime contractor with government SE&I responsibility (government oversight). 4d.Prime contractors with total system performance responsibility (TSPR). 5. Prime contractor with government SE&I responsibility and integration products through a Federally Funded Research and Development Center (FFRDC). 6. Government/FFRDC in-house development with SE&I responsibility and function. The organizational structure used most often was number 4, using a prime contractor with government SE&I responsibility and government technical insight. However, data analyses did not establish a positive relationship between program development costs and specific SE&I organizational types, nor did it positively determine the relationship between successful programs or projects and their SE&I structure. The SE&I study reached the following conclusions: (1) Large, long-duration, technically complex programs or projects reach their technical goals, but rarely meet schedule or cost goals. NASA's recent

  11. [Gonadal function in Turner syndrome].

    PubMed

    Alves, Márcia; Bastos, Margarida; Almeida Santos, Teresa; Carrilho, Francisco

    2013-01-01

    Introdução: A síndrome de Turner caracteriza-se pela ausência, parcial ou total, de um cromossoma X no sexo feminino, sendo uma das cromossomopatias mais frequentes. O diagnóstico é realizado através do cariótipo e as suas manifestações incluem o hipogonadismo primário, antes ou após a puberdade (disgenesia gonadal). O grau de disfunção e a extensão dos defeitos gonadais são variáveis.Objectivos: Pretendeu-se avaliar a clínica, cariótipo, função gonadal e características ecográficas do útero e ovários de mulheres com síndrome de Turner.Material e Métodos: Estudo retrospectivo de doentes com síndrome de Turner, seguidas nos Serviços de Endocrinologia ou Reprodução Humana dos Hospitais da Universidade de Coimbra - Centro Hospitalar e Universitário de Coimbra, E.P.E. Avaliou-se toda a amostra e consideraram-se o grupo 1 (com puberdade e menarca espontânea) e grupo 2 (sem puberdade espontânea). Parâmetros avaliados: idade do estudo inicial, puberdade, cariótipo, FSH, ecografia pélvica inicial e pós-pubertária, celioscopia e indução pubertária. Estudo estatístico: SPSS (20.0).Resultados: Amostra: 79 doentes, 14,7 ± 6,6 anos. Ausência de sinais pubertários em 57,1%, amenorreia primária 67,1% e secundária 6,6%. Cariótipo: monossomia X-37,2%, mosaico-37,2%, alterações estruturais de X-25,6%. Mediana da FSH 59,5mUI/mL. Ecografia inicial: útero normal-34,2%, atrófico-65,8%; ovários normais-21,6%, atróficos-78,4%, com folículos-5,1%. Ecografia pós-pubertária: útero normal-67,9%, atrófico-32,1%; ovários normais-36,4%, atróficos-63,6%. A laparoscopia realizada em 16 (20,3%) doentes confirmou os achados ecográficos. Duas mulheres com puberdade induzida engravidaram: uma espontaneamente, sem evolução; outra pordoação de ovócitos, evolutiva. Grupo 1 (com puberdade e menarca espontânea): 20 (25,3%) doentes, 16,1 ± 8,9 anos. Puberdade na avaliação inicial: M1-22,2%, M2-33,3%, M3-16,7%, M4-16,7%, M5-11,1%. Cari

  12. Correlation between nasopharyngoscopy and cephalometry in the diagnosis of hyperplasia of the pharyngeal tonsils.

    PubMed

    Ritzel, Rodrigo Agne; Berwig, Luana Cristina; da Silva, Ana Maria Toniolo; Corrêa, Eliane Castilhos Rodrigues; Serpa, Eliane Oliveira

    2012-04-01

    Introdução: A hiperplasia de tonsila faríngea é uma das principais causas da respiração oral. O diagnóstico preciso desta alteração é importante para o correto planejamento terapêutico. Em vista disso, estudos têm sido desenvolvidos a fim de fornecer subsídios quanto aos procedimentos que podem ser utilizados para o diagnóstico de obstrução faríngea.Objetivo: Verificar a correlação entre os exames de nasofibrofaringoscopia e cefalometria no diagnóstico de hiperplasia de tonsila faríngea.Método: Estudo transversal, clínico e experimental. Participaram deste estudo 55 crianças, 30 meninas e 25 meninos, com idades entre 7 e 11 anos. As crianças foram submetidas à avaliação nasofibrofaringoscópica e cefalométrica para a determinação do grau de obstrução da nasofaringe. Para verificar a correlação entre esses exames foi utilizado o coeficiente de correlação de Spearman ao nível de significância de 5%.Resultados: Na nasofibrofaringoscopia a maioria das crianças apresentou hiperplasia de tonsila faríngea graus 2 e 3, seguidas de grau 1. Na cefalometria a maior parte das crianças apresentou hiperplasia de tonsilas faríngeas grau 1, seguida de grau 2. Na correlação entre os exames, evidenciou-se correlação regular e positiva.Conclusão: A avaliação da hiperplasia de tonsilas faríngeas pode ser realizada pela nasofibrofaringoscopia e pela cefalometria, pois estes exames apresentam uma relação regular e positiva. No entanto, verificou-se que a cefalometria tende a subestimar o tamanho da tonsila faríngea em relação à nasofibrofaringoscopia.

  13. [Prevalence of chromosomal abnormalities in spontaneous abortions or fetal deaths].

    PubMed

    Bastos, Raquel; Ramalho, Carla; Dória, Sofia

    2014-01-01

    Introdução: O abortamento espontâneo é um dos problemas mais frequentes da gravidez, estimando-se que afete, pelo menos, 25% das mulheres que tentam engravidar. O objetivo principal deste trabalho foi o estudo da prevalência das anomalias cromossómicas em perdas gestacionais, analisando a sua relação com a idade materna, idade gestacional e história de abortamentos prévios.Material e Métodos: Realizou-se um estudo retrospetivo em 401 casos de perdas de gravidez que efetuaram análise citogenética e anátomo-patológica, entre janeiro de 2008 e junho de 2012, no Centro Hospitalar de S. João.Resultados: Dos 401 casos enviados para estudo citogenético foi possível obter informação sobre o complemento cromossómico em 333 casos, dos quais 72,7% apresentaram cariótipo normal e 27,3% cariótipo anormal. As aneuploidias representaram 92,3% das cromossomopatias identificadas, sendo as trissomias as mais frequentes, associadas a uma idade materna avançada e a uma idade gestacional precoce. Não se verificou concordância entre os resultados da análise anátomo-patológica e citogenética.Discussão e Conclusão: A prevalência de anomalias cromossómicas, no primeiro trimestre, foi semelhante entre os casos de abortamento esporádico e recorrente. Com o aumento da idade materna observou-se um aumento das trissomias, com um incremento médio de 7,4% no risco de ocorrência por ano. Não foi estabelecida uma correlação cariótipo-patológica significativa. A contaminação materna da amostra foi o principal entrave à determinação exata da prevalência de anomalias cromossómicas. As técnicas de citogenética molecular já disponíveis podem colmatar esta e outras limitações da técnica convencional.

  14. [231 laparoscopic cholecystectomy in ambulatory: what results?].

    PubMed

    Goulart, André; Delgado, Margarida; Antunes, Maria Conceição; Braga Dos Anjos, João

    2013-01-01

    Introdução: A colecistectomia laparoscópica é actualmente o gold standard no tratamento da patologia litiásica vesicular e colecistite aguda. A sua realização em regime de cirurgia de ambulatório permanece em discussão. O presente estudo tem por objectivo analisar a qualidade e segurança das colecistectomias laparoscópicas realizadas pela Unidade de Cirurgia de Ambulatório do Hospital de Braga e comparar os resultados com outros centros europeus que realizam colecistectomia laparoscópica em regime de ambulatório.Material e Métodos: Estudo observacional prospectivo de doentes submetidos a colecistectomia laparoscópica em regime de ambulatório durante 26 meses. Foram recolhidos dados referentes à demografia do doente, complicações peri e pós-operatórias, tempo cirúrgico e tempo de permanência no recobro e internamentos não programados.Resultados: Foram submetidos a colecistectomia laparoscópica em regime de ambulatório com pernoita (alta < 24h) 231 doentes. Três doentes tiveram intercorrências intra-operatórias com necessidade de conversão para laparotomia e quatro doentes foram internados após a cirurgia. O tempo médio de cirurgia foi de 58 minutos e o tempo médio de recobro de 19h19m. A morbilidade pósoperatória foi de 7,8% tendo, ocorrido dois internamentos não programados.Discussão: Uma das discussões que existe em torno da colecistectomia laparoscópica em regime de ambulatório é a necessidade de vigilância hospitalar durante a primeira noite após a cirurgia. Na nossa unidade, iniciamos a realização da colecistectomia laparoscópica em regime de ambulatório com pernoita hospitalar. Os resultados de mais de dois anos e 231 doentes operados a colecistectomia laparoscópica mostram que é uma técnica perfeitamente segura em regime de ambulatório.Conclusões: Os dados do estudo mostram que a colecistectomia laparoscópica é uma técnica segura em regime de ambulatório, com resultados semelhantes comparativamente com

  15. A Introdução de Astronomia Básica para Estudantes de 5 e 6 Séries do Ensino Fundamental

    NASA Astrophysics Data System (ADS)

    Gonzaga, E. P.; Voelzke, M. R.

    2008-09-01

    Com intuito de despertar o interesse pelo estudo da astronomia, desenvolveu-se entre 2003 e 2006 no Centro Educacional do Serviço Social da Indústria situado no município de Mauá, São Paulo, um trabalho com duração de 12 meses para turmas de 11 e 12 anos, sendo três turmas por período (2003 / 2004, 2004 / 2005 e 2005 / 2006). O trabalho realizado, objetivando a introdução da astronomia básica com observações de constelações e das fases da Lua, permitindo estender-se a outros corpos celestes, iniciou-se com visita ao planetário Mundo Estelar, localizado no Ipiranga, São Paulo levantou-se a questão da importância do estudo da astronomia e foi lançado aos estudantes um trabalho de observação, com a proposta de localizar as constelações e compreender as fases da Lua, para o registro de tais observações, foram distribuídos mapas celestes, pastas, planilhas de anotações com lacunas para, constelações, fases da Lua e relatos, onde os estudantes acrescentaram pesquisas e relatórios. Os resultados dos 346 estudantes foram que 86,7% (300) concluíram a etapa de observação, destes 300 estudantes 43,3% (130) pesquisaram sobre as constelações e 19,0% (57) localizaram até quatro constelações. Dos 346 estudantes, 44,2% (153) registraram as fases da Lua equivocadamente e 10,4% (36) anexaram reportagens sobre astronomia. Conclui-se que os estudantes se dividiram em pesquisadores, sendo os estudantes que registraram e anexaram informações e, os observadores que preencheram as planilhas de observações, além de desenvolverem habilidades e competências relacionadas ao estudo da astronomia.

  16. Adult Acne: Prevalence and Portrayal in Primary Healthcare Patients, in the Greater Porto Area, Portugal.

    PubMed

    Semedo, Diogo; Ladeiro, Filipa; Ruivo, Mariana; D'Oliveira, Carlos; De Sousa, Filipa; Gayo, Mariana; Lima, Clara; Magalhães, Frederico; Brandão, Rui; Branco, Maria; Da Silva, Isabel; Batista, Joana; Amado, João; Massa, António; Neves-Amado, João

    2016-09-01

    Introdução: A acne, apesar de caraterística no adolescente, afeta frequentemente o adulto. Em Portugal, não são conhecidos estudos sobre a prevalência da acne no adulto, nomeadamente observada nos grandes centros populacionais. Os objetivos deste estudo foram estimar a prevalência da acne nos utentes dos serviços de cuidados de saúde primários, as suas características, incluindo fatores de risco para início e/ou agravamento, além de coletar informação relacionada com a automedicação e/ou tratamento prescrito. Material e Métodos: Aplicação de questionário e exame físico a amostra composta por adultos entre os 20 - 60 anos de idade que visitaram, em dias aleatórios, cinco centros de saúde da área do Grande Porto. Resultados: Dos 1 055 adultos avaliados, a prevalência estimada de acne foi de 61,5%. Apenas 36,8% dos portadores estavam cientes da sua condição e somente 25% afirmou ter procurado tratamento. Mais de metade dos fumadores (62,3%) apresentavam acne. A zona mais afetada foi a região malar, diferindo da forma adolescente da doença. Discussão: A prevalência encontrada de acne foi mais elevada do que em outros estudos. A acne aparentou estar relacionada com a ingestão calórica aumentada, tabagismo, consumo de leite gordo ou meio gordo, hirsutismo, alopécia e seborreia. Conclusão: No contexto dos cuidados de saúde primários, mais de metade dos adultos eram portadores de acne. Estes números demonstram o quão importante pode ser a prevenção e intervenção pelos profissionais dos cuidados de saúde primários, tanto para a redução de eventuais factores de risco como para a intervenção terapêutica e consequências psicossociais relacionadas com a acne. Palavras-chave: Acne Vulgaris/epidemiologia; Adulto; Cuidados de Saúde Primários; Portugal; Prevalência.

  17. Health Inequalities in Diabetes Mellitus and Hypertension: A Parish Level Study in the Northern Region of Portugal.

    PubMed

    Leao, Teresa; Perelman, Julian; Felício, Manuela; Machado, Vasco; Lima, Graça

    2016-10-01

    Introdução: A diabetes mellitus e a hipertensão arterial são problemas de saúde de elevada prevalência em Portugal. A sua distribuição geográfica e social é pouco conhecida, comprometendo o desenho e implementação de políticas de saúde. Assim, este estudo teve como objetivo avaliar a existência das desigualdades socioeconómicas na prevalência de diabetes mellitus tipo 2 e hipertensão arterial, na população residente na região Norte de Portugal, no ano de 2013. Material e Métodos: Foi realizado um estudo ecológico que analisou as 2 028 freguesias da região Norte. Os dados foram obtidos através do Sistema de Informação das Administrações Regionais de Saúde e do Censos 2011. A associação entre indicadores socioeconómicos e prevalência destas doenças foi medida pela diferença de prevalências, risco atribuível populacional, índice relativo de desigualdades e coeficiente de regressão. Resultados: A prevalência de diabetes mellitus tipo 2 e hipertensão arterial foi de 6,16% e de 19,35%, respetivamente, e variou entre freguesias. A prevalência de ambas as doenças associou-se significativamente com o baixo nível educacional, baixa atividade no sector terciário, desemprego e baixo rendimento (diferença de prevalências entre decis opostos até 1,3% e 5,3%). Os determinantes socioeconómicos foram responsáveis até 20% da prevalência na população. Discussão: Este tipo de estudo não permitiu a análise de causalidade e poderá ter subestimado as desigualdades socioeconómicas. Contudo, os resultados obtidos alinham-se com a evidência científica internacional. Conclusão: Estes resultados demonstram a existência de uma distribuição socioeconómica e geográfica heterogénea e a necessidade de criação de políticas de saúde que atuem nas freguesias menos favorecidas.

  18. [Thyroid Metastasis as the Initial Presentation of an Asymptomatic Clear Cell Renal Carcinoma].

    PubMed

    Carmelino, Janine; Tavares, Ana Paula; Crespo, Ana; Coutinho, José Mário; Lázaro, António; Ribeiro, Vasco; Barroso, Eduardo

    2016-11-01

    Introdução: A metastização para a glândula tiroideia de um carcinoma renal de células claras é rara e só diagnosticável após análise imunohistoquímica de uma amostra histológica. O objetivo deste artigo é reportar um caso de metastização tiroideia como primeira manifestação de um carcinoma renal de células claras.Caso Clínico: Doente do sexo masculino com um nódulo sólido no lobo esquerdo da tiróide, com 5,3 cm, suspeito de malignidade, submetido a tiroidectomia total com linfadenectomia do compartimento central. A análise histológica concluiu serem duas metástases de carcinoma renal de células claras. Após estudo dirigido ao rim, o doente foi submetido a nefrectomia radical quatro meses depois. Discussão: O interesse deste caso reside no facto de a metastização para a tiroide como primeira manifestação de carcinoma renal de células claras ser rara mas, se tratada precocemente, permite uma ‘dupla resseção cirúrgica’ que pode levar a sobrevidas aos cinco anos de 80%.

  19. Osteotomy at low-speed drilling without irrigation versus high-speed drilling with irrigation: an experimental study.

    PubMed

    Gaspar, João; Borrecho, Gonçalo; Oliveira, Pedro; Salvado, Francisco; Martins dos Santos, José

    2013-01-01

    Introdução: A cirurgia traumática pode afetar a maturação do tecido ósseo e, diminuir a previsibilidade de osteointegração, pelo que a lesão mecânica e térmica deve ser minimizada. O objectivo deste estudo foi avaliar as alterações histológicas imediatas provocadas pela osteotomia a 50 rpm sem irrigação e a 800 rpm com irrigação, no osso do coelho.Material e Métodos: Foram efectuadas 36 perfurações (18 com cada técnica) nas tíbias de seis coelhos adultos. A sequência debrocas utilizada foi: uma broca esférica com 1,5 mm de diâmetro, uma broca piloto com 2,0 mm de diâmetro, e uma broca com 3,5 mm de diâmetro. A cortical posterior das tíbias foi preservada, constituindo o osso de controlo. Procedeu-se à recolha das tíbias com os defeitos a analisar, para observação com microscópio óptico e análise qualitativa.Resultados: Os defeitos ósseos apresentaram bordos regulares. Observou-se tecido ósseo viável, vascularizado e com presença de osteócitos junto aos defeitos. A estrutura haversiana e lamelar do tecido encontrou-se mantida, bem como a rede vascular. A matriz extracelular não apresentou alterações. Os resultados indicam não haver diferenças histológicas entre as osteotomias a 800 rpm com irrigação e a 50 rpm sem irrigação.Conclusão: O nosso estudo sugere que as alterações no tecido ósseo provocadas pela osteotomia a 50 rpm sem irrigação e a 800 rpm com irrigação são semelhantes, e que ambas as técnicas mantêm o tecido ósseo viável para a colocação de implantes e respectiva osteointegração, cabendo ao clínico a escolha, em função de outras variáveis.

  20. TIBIOTARSAL COMPRESSION ARTHRODESIS USING A LATERAL LOCKING PLATE.

    PubMed

    Coughlin, Michael J; Nery, Caio; Baumfeld, Daniel; Jastifer, James

    2012-01-01

    Objetivos: A artrodese tibiotársica (TT) continua sendo uma importante opção no tratamento da artrose primária ou pós-traumática do tornozelo mas persiste ainda a controvérsia sobre o melhor método de fixação do foco de artrodese. Independentemente do tipo de material utilizado, o objetivo maior é a obtenção da fusão articular sólida, saudável e indolor. O propósito do presente estudo é apresentar os resultados preliminares de um novo sistema de placa bloqueada lateral compressiva para a artrodese do tornozelo. Método: Treze pacientes consecutivos portadores de artrose tibiotársica foram submetidos à artrodese do tornozelo nove pacientes eram homens e quatro mulheres. Com o auxílio de um guia, as superfícies articulares do talo e da tíbia foram decorticadas. Um sistema de compressão foi aplicado para evitar o alinhamento indesejável dos segmentos e uma placa bloqueada pré-moldada lateral foi utilizada para obter a fusão articular. Resultados: Tanto o escore AOFAS quanto o VAS melhoraram com a cirurgia. Todos os tornozelos operados consolidaram dentro do prazo de seis meses. Em todos os pacientes, foi obtido um ótimo alinhamento nos planos sagital, coronal e transverso. Conclusão: Acreditamos que a combinação de compressão bilateral, cortes ósseos com contornos pré-demarcados e placa lateral bloqueada, constitui uma técnica moderna, segura e útil para a artrodese do tornozelo.

  1. Diet misreporting can be corrected: confirmation of the association between energy intake and fat-free mass in adolescents.

    PubMed

    Vainik, Uku; Konstabel, Kenn; Lätt, Evelin; Mäestu, Jarek; Purge, Priit; Jürimäe, Jaak

    2016-10-01

    Subjective energy intake (sEI) is often misreported, providing unreliable estimates of energy consumed. Therefore, relating sEI data to health outcomes is difficult. Recently, Börnhorst et al. compared various methods to correct sEI-based energy intake estimates. They criticised approaches that categorise participants as under-reporters, plausible reporters and over-reporters based on the sEI:total energy expenditure (TEE) ratio, and thereafter use these categories as statistical covariates or exclusion criteria. Instead, they recommended using external predictors of sEI misreporting as statistical covariates. We sought to confirm and extend these findings. Using a sample of 190 adolescent boys (mean age=14), we demonstrated that dual-energy X-ray absorptiometry-measured fat-free mass is strongly associated with objective energy intake data (onsite weighted breakfast), but the association with sEI (previous 3-d dietary interview) is weak. Comparing sEI with TEE revealed that sEI was mostly under-reported (74 %). Interestingly, statistically controlling for dietary reporting groups or restricting samples to plausible reporters created a stronger-than-expected association between fat-free mass and sEI. However, the association was an artifact caused by selection bias - that is, data re-sampling and simulations showed that these methods overestimated the effect size because fat-free mass was related to sEI both directly and indirectly via TEE. A more realistic association between sEI and fat-free mass was obtained when the model included common predictors of misreporting (e.g. BMI, restraint). To conclude, restricting sEI data only to plausible reporters can cause selection bias and inflated associations in later analyses. Therefore, we further support statistically correcting sEI data in nutritional analyses. The script for running simulations is provided.

  2. [Restraints to anticoagulation prescription in atrial fibrillation and attitude towards the new oral anticoagulants].

    PubMed

    Pereira-Da-Silva, Tiago; Souto Moura, Teresa; Azevedo, Luísa; Sá Pereira, Margarida; Virella, Daniel; Alves, Marta; Borges, Luís

    2013-01-01

    Introdução e Objetivos: Avaliar a taxa de prescrição de anticoagulantes orais na fibrilhação auricular, os fatores associados à não prescrição, os motivos referidos pelos clínicos para não prescrição de anticoagulantes incluindo os de nova geração e realizar estudo evolutivo a médio prazo. Material e Métodos: Estudo prospetivo sobre casos consecutivos de doentes com fibrilhação auricular com alta hospitalar. Registaram- se os scores CHA2DS2VASc e HASBLED, comorbilidades associadas e a medicação prévia e à data de alta. Na alta hospitalar, o médico assistente indicou em questionário o motivo de não prescrição de anticoagulantes orais e dos novos anticoagulantes orais. Exclusão: contra-indicação absoluta para anticoagulação, CHA2DS2VASc ≤ 1 e doença valvular. Os doentes foram reavaliados um ano após o recrutamento do primeiro doente. Resultados: Identificaram-se 103 candidatos a anticoagulação oral (79,6 ± 8,0 anos; CHA2DS2VASc 5,8 ± 1,4; HASBLED 2,6 ± 1,0; HASBLED ≥ 3 em 55,3%); os anticoagulantes foram prescritos em 34,0%. Fatores associados à não prescrição por ordem decrescente de relevância: uso prévio de antiagregantes, doente acamado e/ou demente, ausência de insuficiência cardíaca e número de fatores de risco hemorrágico. Razões invocadas para não prescrição por ordem decrescente de frequência: risco hemorrágico elevado, pequeno benefício, incapacidade de seguir o esquema terapêutico e dificuldade na monitorização da razão normalizada internacional (INR). Os novos anticoagulantes não foram prescritos e as razões invocadas foram, por ordem decrescente de frequência: informação insuficiente sobre estes fármacos, risco hemorrágico elevado, custo elevado e pequeno benefício. Aos 8,2 ± 2,5 meses de estudo evolutivo 33,3% dos doentes encontravam-se sob anticoagulação sem que os novos anticoagulantes tivessem sido prescritos. Conclusões: Nesta amostra, a taxa de prescrição de

  3. [Esophageal cancer: surgical strategies].

    PubMed

    Costa, Paulo; Esteves, Rui; Lages, Patrícia; Ferreira, Filipa

    2014-01-01

    Introdução: A ressecção transmediastínica e a ressecção transtorácica têm mortalidade hospitalar (1,4% -14%) e sobrevivência (± 25% aos cinco anos) semelhantes. A terapêutica neo-adjuvante é opção em estádios avançados. A intenção deste trabalho é apresentar uma série consecutiva de 52 doentes - opção operatória baseada na localização anatómica: tumores infra-carinais e cervicais submetidos a ressecção transmediastínica e restantes ressecções transtorácicas.Material e Métodos: O estudo incluiu 52 doentes consecutivos, sete mulheres e 45 homens, mediana de idade: 64 anos [46- 85]. Localização: cervical – um; montante da carina - 22; jusante da carina -19; cárdia tipo I –10. Histologia: 19 adenocarcinomas, 32 carcinomas pavimento-celulares, um linfoma. Vinte doentes (40%) - terapêutica neoadjuvante. Abordagem tóraco-abdominal – três, tóraco-abdómino-cervical – 20, transhiatal – 27, toracotomia exploradora – dois. Transposição gástrica 49 (anastomose cervical – 46; torácica - três); esofagocoloplastia cervical - um.Resultados: Estadiamento patológico: regressão completa - 8; Ib – 3; IIa – 9; IIb - 4; IIa – 11; IIIb -2; IIIc – 10; IV – 1; linfoma - um; não classificáveis – três. Complicações major: 37%. Ressecabilidade: 96% (50/52). Mortalidade: quatro semanas - 6%; hospitalar - 14%. Sobrevida mediana 18 meses [3-80]. Curvas de sobrevida (Kaplan-Meier): dois anos - 47%; cinco anos - 19%.Discussão: Não tendo sido demonstrada vantagem oncológica para a ressecção transtorácica ou a ressecção transmediastínica,basear a opção operatória na localização do tumor permitiu-nos com segurança e eficácia, planear e executar as ressecções esofágicas desta série.Conclusão: As curvas de sobrevida foram sobreponíveis para ressecção transtorácica e ressecção transmediastínica e bastantefavoráveis numa população com 52 % de estádios p

  4. [Allergic contact dermatitis to metals over a 20-year period in the Centre of Portugal: evaluation of the effects of the European directives].

    PubMed

    Teixeira, Vera; Coutinho, Inês; Gonçalo, Margarida

    2014-01-01

    Introdução: Os metais são causa frequente de dermatite de contacto alérgica. Desde a introdução da Directiva Comunitária do Níquel (1994/27/CE; 2004/96/CE) e, mais recentemente, da Directiva do Cimento (2003/53/CE), nos países nórdicos tem havido uma diminuição da sensibilização aos metais. A aplicabilidade destas medidas e o seu impacto permanece por avaliar em Portugal. Material e Métodos: Foi realizado um estudo retrospectivo (1992-2011) na Consulta de Alergologia Cutânea com o principal objectivo de analisar a variação dos padrões de sensibilização aos metais (níquel [Ni], cobalto [Co] e crómio [Cr]) ao longo de 20 anos, em particular no que se refere ao género, grupo etário e relação com a actividade profissional. Resultados: Do total de 5 250 doentes estudados, em 1 626 (31%) observámos pelo menos um teste epicutâneo positivo a um metal (26,5% ao Ni; 10,0% ao Co e 7,0% ao Cr). A prevalência de sensibilização ao Ni era significativamente maior nas mulheres (34,4% versus 8,9%) e ao Cr nos homens (11,5% versus 5,0%). Não houve diminuição significativa da sensibilização ao Ni ao longo dos 20 anos, mas o contributo da faixa etária dos 16-30 anos no total de mulheres sensíveis a este metal decresceu de forma significativamente estatística ao longo dos anos (p < 0,001). A sensibilização ao Cr decresceu sobretudo nos homens (r = -0,535), muito particularmente nos casos relacionados com a construção civil (r = -0,639), enquanto a reatividade ao Cr relacionado com o uso de calçado se manteve estável. Discussão: A manutenção dos elevados níveis de sensibilização ao níquel denota ainda uma fraca implementação das Directivas comunitárias mas a redução da percentagem de mulheres jovens poderá significar já algum efeito positivo nesta faixa etária. Ao contrário, a Directiva referente à redução do Cr no cimento parece estar a ter os seus efeitos positivos. Há, contudo, necessidade de interferir com o conte

  5. Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia

    PubMed Central

    Cha, Joo Young; Wee, Jungwon; Jung, Jooyoung; Jang, Yongwoo; Lee, Byeongjun; Hong, Gyu-Sang; Chang, Beom Chul; Choi, Yoon-La; Shin, Young Kee; Min, Hye-Young; Lee, Ho-Young; Na, Tae-Young; Lee, Mi-Ock; Oh, Uhtaek

    2015-01-01

    Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate, causing lower urinary tract symptoms in elderly men worldwide. However, the molecular mechanism underlying the pathogenesis of BPH is unclear. Anoctamin1 (ANO1) encodes a Ca2+-activated chloride channel (CaCC) that mediates various physiological functions. Here, we demonstrate that it is essential for testosterone-induced BPH. ANO1 was highly amplified in dihydrotestosterone (DHT)-treated prostate epithelial cells, whereas the selective knockdown of ANO1 inhibited DHT-induced cell proliferation. Three androgen-response elements were found in the ANO1 promoter region, which is relevant for the DHT-dependent induction of ANO1. Administration of the ANO1 blocker or Ano1 small interfering RNA, inhibited prostate enlargement and reduced histological abnormalities in vivo. We therefore concluded that ANO1 is essential for the development of prostate hyperplasia and is a potential target for the treatment of BPH. PMID:26153424

  6. 75 FR 6065 - Extension of Public Comment Period on the Draft Environmental Impact Statement for the Moore...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... COMMISSION Extension of Public Comment Period on the Draft Environmental Impact Statement for the Moore Ranch... for the NRC's Draft Supplemental Environmental Impact Statement (Draft SEIS) for the Moore Ranch In... public comment period on the Draft SEIS for the Moore Ranch ISR Project to March 3, 2010. DATES:...

  7. Assuring Software Reliability

    DTIC Science & Technology

    2014-08-01

    resources.sei.cmu.edu/asset_files/WhitePaper/2009_019_001_29066.pdf [Boydston 2009] Boydston, A. & Lewis , W. Qualification and Reliability of...Woody, Carol . Survivability Analysis Framework (CMU/SEI-2010-TN-013). Software Engineering Institute, Carnegie Mellon University, 2010. http

  8. 24 CFR 3285.4 - Incorporation by reference (IBR).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...-00, Standard Practice for Classification of Soils for Engineering Purposes (Unified Soil... materials listed below are available for purchase from the Structural Engineering Institute/American Society of Civil Engineers (SEI/ASCE), 1801 Alexander Bell Drive, Reston, Virginia 20191. (1) SEI/ASCE...

  9. 78 FR 77417 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement for the Little Otter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... Environmental Impact Statement for the Little Otter Creek Watershed Plan, Caldwell County, Missouri AGENCY..., will prepare a Supplemental Environmental Impact Statement (SEIS) for the Little Otter Creek Watershed... the Little Otter Creek Watershed Plan and Environmental Impact Statement in 2003. The SEIS will...

  10. A parametric study of non-thermal plasma synthesis of silicon nanoparticles from a chlorinated precursor

    NASA Astrophysics Data System (ADS)

    Ding, Yi; Yamada, Riku; Gresback, Ryan; Zhou, Shu; Pi, Xiaodong; Nozaki, Tomohiro

    2014-12-01

    Silicon nanoparticles (Si NPs) synthesized in non-thermal plasma with silicon tetrachloride (SiCl4) are anticipated as a non-toxic and inexpensive Si source for important applications. This study examines the crystallinity, yield, and size distribution of Si NPs in terms of specific energy input (SEI) for 2.5-65 J cm‒3 and the H2/SiCl4 ratio (1-10). The particle growth mechanism is discussed comprehensively. Atomic hydrogen (H) production using non-thermal plasma is the primary important step for SiCl4 dechlorination at low temperatures. The Si NP yield increases with SEI (plasma power divided by total gas flow) because SiCl4 conversion increases with energy fed into the unit volume of the feed gas. At low SEI, Si NPs were mostly in amorphous material because of insufficient plasma heating. A maximum yield of 50 wt% was obtained when SEI = 10 J cm‒3 (H2/SiCl4 = 10) with a crystal fraction of about 1%. Increased SEI is necessary to improve crystal fraction, but excessive SEI decreases the NP yield remarkably. The NP yield losses correspond to increasing NP-free thin film growth on the reactor wall. Mass spectrometry shows that SiCl4 is highly decomposed with greater SEI. Hydrogen chloride (HCl) increases as a by-product. At higher SEI, particle nucleation and subsequent growth are suppressed.

  11. Science & Engineering Indicators 2016. National Science Board

    ERIC Educational Resources Information Center

    National Science Foundation, 2016

    2016-01-01

    "Science and Engineering Indicators" (SEI) is first and foremost a volume of record comprising high-quality quantitative data on the U.S. and international science and engineering enterprise. SEI includes an overview and seven chapters that follow a generally consistent pattern. The chapter titles are as follows: (1) Elementary and…

  12. Structured English Immersion: A Step-by-Step Guide for K-6 Teachers and Administrators.

    ERIC Educational Resources Information Center

    Haver, Johanna J.

    This book describes Structured English Immersion (SEI) for English language learners (ELLs). Seven chapters focus on the following: (1) "Identification, Assessment, and Placement" (e.g., California's school districts implement SEI and proper placement of students); (2) "Listening Skills" (e.g., time on task, total physical…

  13. Observed and Modeled Bio-Optical, Bioluminescent, and Physical Properties during a Coastal Upwelling Event in Monterey Bay, California

    DTIC Science & Technology

    2011-01-27

    users’ guide, report, Sequoia Sei., Inc., Mercer Island, Wash. (Available at http://www. HydroLight. info). Moblcy, C. D., and L. K. Sundman (2001b...HydroLight 4.2 technical doc- umentation, report. Sequoia Sei.. Inc., Mercer Island. Wash. (Available at http://www.HydroLight.info). Molinc, M

  14. Reading and Language Outcomes of a Five-Year Randomized Evaluation of Transitional Bilingual Education

    ERIC Educational Resources Information Center

    Slavin, Robert E.; Madden, Nancy; Calderon, Margarita; Chamberlain, Anne; Hennessy, Megan

    2010-01-01

    This paper reports the fifth-year results of a study comparing the English and Spanish language and reading performance of Spanish-dominant children randomly assigned beginning in kindergarten to Transitional Bilingual Education (TBE) or Structured English Immersion (SEI). This is the first randomized study to compare TBE and SEI reading…

  15. Improving Teaching Effectiveness through the Application of SPC Methodology

    ERIC Educational Resources Information Center

    Cadden, David; Driscoll, Vincent; Thompson, Mark

    2008-01-01

    One method used extensively to aid in determining instruction effectiveness is Student Evaluations of Instruction (SEI). This paper examines the use of statistical Process Control charts as a way to correctly measure teaching effectiveness. This field studying SEIs has produced a significant literature. It is not surprising that there is…

  16. VAXELN Experimentation: Programming a Real-Time Periodic Task Dispatcher Using VAXELN Ada 1.1

    DTIC Science & Technology

    1987-11-01

    and is approved for publication. FOR THE COMMANDER Karl Shingler SEI Joint Program Office This work is sponsored by the U.S. Department of Defense...34); 28 CMU/SEI-87.TR-532 boom I@. Pat (OXT"rant.mimlteo). slaw- Lise ; WmttedStriaoLvat (0em.dl; BOOCNOZO.Vat (Caguemi S.stio); enale) M%.: i Fremttedl

  17. Exploring Family Environment Characteristics and Multiple Abuse Experiences among Homeless Youth

    ERIC Educational Resources Information Center

    Ferguson, Kristin M.

    2009-01-01

    This qualitative study used data from the Social Enterprise Intervention (SEI) pilot study, a comprehensive vocational training program with integrated clinical services for homeless youth. In-depth interviews were conducted with 28 homeless youth participating in the SEI study to explore their perceptions of family environment characteristics and…

  18. 77 FR 12818 - Intent To Prepare a Draft Supplemental Environmental Impact Statement for the Proposed Rio Grande...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... Salado was filed with the Council on Environmental Quality in 1977. An SEIS evaluating the effects of the... withstand long- duration floods and evaluating effects to recently listed endangered species was filed with... draft SEIS is being developed to evaluate effects of revised levee design and additional...

  19. 75 FR 65558 - Final Supplemental Environmental Impact Statement, Single Nuclear Unit at the Bellefonte Plant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... Final Supplemental Environmental Impact Statement, Single Nuclear Unit at the Bellefonte Plant Site... Nuclear Unit at the Bellefonte Plant Site (final SEIS) on September 9, 2010. The location of the proposed nuclear plant site was stated incorrectly in the heading of the ROD. TVA prepared the final SEIS to...

  20. Tailoring and Combining the CMMI-ACQ and Quality Models to Improve the Military’s Requirements Process

    DTIC Science & Technology

    2008-03-01

    have been used, CAIR (developed at the SEI), Semio Text, TextSmart, Lexiquest Mine and Leximancer . This is not an exhaustive list and SEI does not...following describes the approach used with Leximancer . 13 Tailoring and Combining the CMMI-ACQ and Quality Models to Improve the Military’s

  1. Evaluation of the Rational Environment

    DTIC Science & Technology

    1988-07-01

    three evaluations of the Delta release of the Rational Environments. John Devitofran- ceschi took care of the Rational machine at the SEI. Frost...Feiler, P. H., Smeaton , R. The Project Management Experiment: Evaluation of Ada Environments. Technical Report CMU/SEI-88-TR-7, Software Engineering

  2. Using TSP Data to Evaluate Your Project Performance

    DTIC Science & Technology

    2010-09-01

    Accounting Data,” Journal of Forensic Accounting 1524-5586/vol. V (2004), pp 17-34, R.T. Edwards, Inc., 2004. [Fahmi 2008] Fahmi, Syed Ahsan and Choi ...Marsha, Team Software Process (TSP) Body of Knowledge ( BOK ) (CMU/SEI-2010-TR-020). Carnegie Mellon University, 2010. www.sei.cmu.edu/library/abstracts

  3. 76 FR 55723 - Final Supplemental Environmental Impact Statement, Sequoyah Nuclear Plant Units 1 and 2 License...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... (SQN) in Soddy-Daisy, Tennessee. A notice of availability (NOA) of the Sequoyah License Renewal Final... Protection Agency (USEPA) published the NOA for the Draft SEIS in the Federal Register on November 5, 2010... considering and responding to all substantive comments, TVA completed and issued the Final SEIS. The NOA...

  4. 76 FR 21711 - Notice of Extension of Public Comment Period for the Draft Supplemental Environmental Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    .... A Notice of Availability (NOA) and Notice of Public Hearing (NOPH) for the Draft SEIS were published... Final Environmental Impact Statement for the Disposal and Reuse of HPS (March 2000). A NOA and NOPH for... information of the Draft SEIS can be found in the previously published NOA and NOPH (see Federal...

  5. From a lunar outpost to Mars: science, policy and the U.S. Space Exploration Initiative.

    PubMed

    Pilcher, C B

    1992-01-01

    The U.S. Space Exploration Initiative (SEI) is aimed at the establishment of an outpost for humans on the Moon, followed by the human exploration of Mars. It also encompasses robotic missions to the Moon and Man that will precede and perhaps accompany human presence. Science plays a dual role in SEI. First, many scientific questions must be answered to insure the health and safety of human explorers. Second, scientific investigations will be among the central objectives of human explorers. A substantial body of U.S. policy on SEI has been announced by President Bush. Its implementation is coordinated by the U.S. National Space Council under the Chairmanship of Vice President Quayle. That policy directs the early focus of SEI to be on technology development, including the identification of "high leverage technologies," and the identification of alternative mission architectures. It also envisions international cooperation as an important beneficial aspect of SEI.

  6. Single nanowire electrode electrochemistry of silicon anode by in situ atomic force microscopy: solid electrolyte interphase growth and mechanical properties.

    PubMed

    Liu, Xing-Rui; Deng, Xin; Liu, Ran-Ran; Yan, Hui-Juan; Guo, Yu-Guo; Wang, Dong; Wan, Li-Jun

    2014-11-26

    Silicon nanowires (SiNWs) have attracted great attention as promising anode materials for lithium ion batteries (LIBs) on account of their high capacity and improved cyclability compared with bulk silicon. The interface behavior, especially the solid electrolyte interphase (SEI), plays a significant role in the performance and stability of the electrodes. We report herein an in situ single nanowire atomic force microscopy (AFM) method to investigate the interface electrochemistry of silicon nanowire (SiNW) electrode. The morphology and Young's modulus of the individual SiNW anode surface during the SEI growth were quantitatively tracked. Three distinct stages of the SEI formation on the SiNW anode were observed. On the basis of the potential-dependent morphology and Young's modulus evolution of SEI, a mixture-packing structural model was proposed for the SEI film on SiNW anode.

  7. Social inequality in health: revisiting moments and trends in 50 years of publication of RSP.

    PubMed

    Barros, Marilisa Berti de Azevedo

    2017-03-23

    This study describes the frequency and types of articles on social inequalities in health published in 50 years of the Revista de Saúde Pública, taking as reference some milestones that were used as guidelines to develop the research on this theme. Checking titles, keywords and abstracts or full texts, we identified 288 articles whose central or secondary focus was social inequalities in health. Corresponding to just 1.8% in the initial years, articles on social inequalities in health have represent 10.1% of the articles published in the last decade. The designs used were mainly cross-sectional (58.0%) and ecological (18.1%). The most analyzed themes were: food/nutrition (20.8%), mortality (13.5%), infectious diseases (10.1%), oral health (9.0%), and health services (8.7%). Articles focused on the analysis of racial inequalities in health amounted to 6.9%. Few articles monitored the trends of social inequalities in health, essential enterprise to assess and support interventions, and an even smaller number evaluated the impact of policies and programs on the reduction of social inequalities in health. RESUMO Este estudo descreve a frequência e os tipos de artigos sobre desigualdades sociais em saúde publicados nos 50 anos da Revista de Saúde Pública, tomando por referência alguns marcos que balizaram o desenvolvimento das investigações nessa temática. Checando títulos, palavras-chave e resumos ou textos completos, foram identificados 288 artigos cujo foco central ou secundário era desigualdades sociais em saúde. Correspondendo a apenas 1,8% nos anos iniciais, artigos sobre desigualdades sociais em saúde chegaram a representar 10,1% dos publicados na última década. Os desenhos utilizados foram principalmente transversais (58,0%) e ecológicos espaciais (18,1%). Os temas mais analisados foram: alimentação/nutrição (20,8%), mortalidade (13,5%), doenças infecciosas (10,1%), saúde bucal (9,0%) e serviços de saúde (8,7%). Artigos voltados à an

  8. ANÁLISE DA INSERÇÃO DOS TEMAS DE HUMANIDADES E ÉTICA, COM METODOLOGIA DE APRENDIZAGEM BASEADA EM PROBLEMAS, EM CURRICULO MÉDICO INTEGRADO EM ESCOLA PÚBLICA NO DISTRITO FEDERAL, BRASIL

    PubMed Central

    Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Lolas, Fernando; Silveira, Carla; Guiotti, Murilo

    2009-01-01

    Objetivo Realizar uma análise da inserção da ética e humanidades no currículo do Curso de Medicina da Escola Superior em Ciências da Saúde - ESCS, escola pública do Distrito Federal, Brasil, de forma a contribuir com o processo de gestão curricular. Metodologia O Estudo é de coorte e documental. Foram pesquisados 37 termos relacionados à ética e 36 referentes à humanização nos objetivos educacionais e conteúdo dos módulos temáticos, habilidades e atitudes e interação ensino-serviço-comunidade, de 1a a 4a série e no programa do internato no currículo (ano 2006) e no projeto pedagógico do Curso de Medicina (2001). Resultados Maior inserção da humanização, ética e bioética na 1a e 2a série, quando comparado à inserção na 3a e 4a série e no internato, (IC95%-α=0,034, pvalue=0,007). Unidade de habilidades e atitudes: freqüência das 3 temáticas no currículo da 1a a 4a séries (IC95%-α=0,026, pvalue=0,013). Quando comparada a inserção entre o internato e as quatro primeiras séries, observa-se que nestas a inserção da temática humanização é superior (IC95%-α=0,042, pvalue=0,029). Conclusão O currículo desenvolvido no ano de 2006 na ESCS apresentou correlação com o projeto pedagógico do curso e contemplou a temática de forma abrangente, em todas as séries e internato. PMID:20396594

  9. Malignant Small Bowel Tumors: Diagnosis, Management and Prognosis.

    PubMed

    Cardoso, Hélder; Rodrigues, João Tiago; Marques, Margarida; Ribeiro, Armando; Vilas-Boas, Filipe; Santos-Antunes, João; Rodrigues-Pinto, Eduardo; Silva, Marco; Maia, José Costa; Macedo, Guilherme

    2015-01-01

    Introdução: Apesar de entidades raras, a incidência dos tumores malignos do intestino delgado parece estar a aumentar. O desenvolvimento da cápsula endoscópica e da enteroscopia assistida por balão permitiram um avanço na avaliação das lesões do intestino delgado. Temos como objetivo descrever as características clínicas e patológicas dos doentes com cancro do intestino delgado e averiguar o papel que estas técnicas endoscópicas assumem atualmente. Material e Métodos: Foi realizado um estudo retrospetivo dos doentes diagnosticados com cancro do intestino delgado, desde janeiro de 2010 até outubro de 2014. Os dados foram submetidos a análise estatística. Resultados: Dos 28 doentes diagnosticados, 54% eram do sexo feminino. A idade média ao diagnóstico foi de 61 anos. O tumor mais frequente foi o adenocarcinoma (n = 11), seguido do sarcoma (n = 6), linfoma (n = 6) e tumores neuroendócrinos (n = 3). A principal forma de apresentação esteve relacionada com perdas hemáticas ou obstrução intestinal. Ao diagnóstico, 46% dos doentes tinhammetástases distantes/tumor irressecável. A maioria dos tumores foi diagnosticada por técnicas endoscópicas (41%) ou imagiológicas (35%). No primeiro ano após o diagnóstico, 29% dos doentes faleceram. Na análise multivariada, o adenocarcinoma permaneceu fator independente para pior sobrevida. Discussão: Os doentes com adenocarcinoma apresentaram-se em estádios tardios e com tumores irressecáveis, contribuindo para um pior prognóstico. Ã necessário um elevado grau de suspeita clínica para o diagnóstico de cancro do intestino delgado. Conclusão: As características dos doentes foram globalmente consistentes com o descrito na literatura. A cápsula endoscópica e a enteroscopia assistida por balão são úteis no diagnóstico, gestão e vigilância do cancro do intestino delgado.

  10. [Anxiety in clinical settings: constructing a scale for medical students].

    PubMed

    Rodrigues, Joana Ramos; Castelo-Branco, Miguel; Pereira, Henrique; Afonso, Rosa Marina

    2014-01-01

    IntroduçÉo: A Escala de Ansiedade em Meio Clínico foi construída para avaliar o nível de ansiedade dos estudantes de Medicina quando expostos ao meio clínico e identificar quais as situações mais propensas a desencadear maior nível de ansiedade nesse contexto.Material e Métodos: Este instrumento é constituído por doze itens e foi construído tendo por base a revisÉo da literatura sobre a temática da ansiedade em meio clínico e os dados provenientes de um focus group realizado com estudantes entre o 1'º e o 5'º ano do curso de Medicina da Universidade da Beira Interior (n = 10). As suas propriedades psicométricas foram testadas mediante um estudo com 557 alunos do curso de Medicina de quatro universidades portuguesas, entre o 1'º e o 6'º ano.Resultados: A validaçÉo da Escala de Ansiedade em Meio Clínico contemplou a análise de três par'metros principais: sensibilidade, fiabilidade e análise da estrutura fatorial, sendo que a última resultou na obtençÉo de quatro factores: 'Incómodo perante procedimentos invasivos', 'Ansiedade face ao doente', 'Ansiedade face ao desempenho' e 'Ansiedade face à dimensÉo humana' com 70,6% da vari'ncia explicada.DiscussÉo: A Escala de Ansiedade em Meio Clínico total demonstra uma boa coerência interna (Alpha de Cronbach = 0,84) e boa capacidade de discriminaçÉo de sujeitos, apresentando-se, assim, como instrumento consistente e fiável para a avaliaçÉo de ansiedade nos estudantes de Medicina quando expostos ao meio clínico.ConclusÉo: A Escala de Ansiedade em Meio Clínico permite avaliar a ansiedade nos estudantes de Medicina quando expostos ao meio clínico e poderá vir a ser útil na delineaçÉo de estratégias de ensino para a preparaçÉo dos futuros médicos.

  11. Evaluation of functional recovery by motor functional independence measure test of elderly after hip fracture in Serbia.

    PubMed

    Radosavljevic, Natasa; Nikolic, Dejan; Lazovic, Milica; Radosavljevic, Zoran; Jeremic, Aleksandar

    2014-01-01

    Introdução: o objectivo do estudo é a avaliação do nível de independência funcional através da aplicação da escala de Medida da Independência Funcional (Functional Independence Measure [FIM]) em doentes com idade superior a 65 anos, após fractura da anca.Material e Métodos: Foram estudados 203 doentes após fractura da anca, aplicando a escala MIF em 3 momentos: admissão do doente no hospital (Período 1), no momento da alta (Período 2) e 3 meses após a alta (Período 3); os doentes foram englobados em 3 grupos etários: Grupo65-74 , Grupo75-84 e Grupo+85 e em dois grupos, consoante o Índice de Gravidade (IG): grupo 0-1,99 (IG1) e grupo ≥ 2 (IG2).Resultados: No grupo de doentes com idêntico IG, observou-se um aumento dos valores da MIF no Período 2 e 3 em ambos osgéneros e nas primeiras duas classes etárias, ao passo que em doentes acima dos 85 anos, com IG mais elevado, observámos uma variação não significativa dos valores da MIF entre o momento da alta hospitalar e 3 meses após a alta.Discussão: A melhoria mais significativa da MIF foi obtida em doentes do sexo feminino no primeiro e terceiro grupos etários e com IG mais elevado.Conclusão: O género não constitui um factor preditivo significativo da recuperação da independência funcional medida através da aplicação da escala MIF em doentes com fractura da anca, embora a MIF no momento da admissão seja um bom indicador de recuperação funcional em doentes do sexo feminino em certos grupos etários (primeiro e terceiro grupos etários).

  12. [Mediterranean Spotted Fever: Retrospective Review of Hospitalized Cases and Predictive Factors of Severe Disease].

    PubMed

    Meireles, Mariana; Magalhães, Rui; Guimas, Arlindo

    2015-01-01

    Introdução: Febre escaro-nodular, uma zoonose antiga a levantar questões actuais. Este estudo pretende reavaliar a imagem clínica da doença e identificar factores prognósticos de doença severa. Material e Métodos: Foram avaliados os casos admitidos num hospital central no período de 12 anos. Os fatores de risco foram determinados por análise uni e multivariada, comparando os indivíduos internados em enfermaria geral versus admitidos em unidades de cuidados intermédios/intensivos ou em caso de morte. Resultados: Foram revistos 71 casos de febre escaro-nodular. A média de idades foi 63,3 ± 16,7 anos e 52,1% eram homens. A escara de inoculação foi identificada em 62,0% dos casos. Febre e exantema foram os achados clínicos mais frequentes. Quarenta e cinco por cento dos doentes desenvolveram complicações e 22,5% foram internados em unidades de cuidados intermédios e/ou intensivos. Apirexia, dispneia, insuficiência renal e níveis de lactato desidrogenase elevados à admissão foram preditores de desenvolvimentode doença severa (p < 0,034). O alcoolismo associou-se a um tempo de internamento prolongado (p = 0,020). Ausênciade febre (p = 0,019) e níveis elevados de creatinina (p = 0,028) constituíram fatores independentes de mau prognóstico. A taxa de mortalidade foi 2,8%.Discussão: Apesar da evolução da febre escaro-nodular ser, geralmente, assumida como benigna, casos graves têm surgido. Quase metade dos doentes hospitalizados desenvolveu complicações. Apirexia e lesão renal predispõem a pior prognóstico. Conclusão: A identificação precoce da infeção e a vigilância contínua dos doentes são determinantes, particularmente naqueles com maior risco de desenvolverem doença severa ou fatal.

  13. [Psychiatric comorbidities associated with headaches: the experience of the liaison consultation].

    PubMed

    Martins, Vera; Temótio, José; Murta, Ilda

    2015-01-01

    Introdução: A comorbilidade entre cefaleias e perturbações psiquiátricas é frequente, podendo ser explicada quer ao nível de modelos uni ou bidirecionais, quer ao nível da partilha de factores de risco genéticos e ambientais, comuns ao desenvolvimento de ambas as condições clínicas. A presença desta comorbilidade tem implicações importantes, agravando o quadro clínico, aumentando o risco de cronicidade, elevando a intensidade da dor e a taxa de insucesso terapêutico. Material e Métodos: Os autores realizaram um estudo descritivo, retrospectivo, de prevalência, envolvendo 250 doentes observados na consulta de ligação de Psiquiatria-Cefaleias, durante um período de 3 anos, entre 1 de Julho de 2011 e 1 de Julho de 2013, no qual se procedeu à análise dos processos clínicos, relativamente aos dados sociodemográficos e clínicos, diagnóstico psiquiátrico, neurológico e terapêutica prescrita. Resultados e Discussão: Foram efectuadas 689 consultas de ligação Psiquiatria-Cefaleias, verificando-se maior prevalência de doentes do sexo feminino (84%), com média de idades de 47 anos. As cefaleias tipo tensão (60,8%), a enxaqueca (24,8%) e as cefaleias atribuídas a perturbações psiquiátricas (7,2%), foram os tipos mais prevalentes, enquanto as perturbações de humor (62%) e as perturbações neuróticas relacionadas com o stress (39,2%) foram os diagnósticos psiquiátricos mais frequentes na consulta. A intervenção terapêutica nestes casos privilegiou a intervenção multidisciplinar do médico Neurologista e do Psiquiatra, baseando-se na psicoeducação, abordagem cognitivo-comportamental e tratamento psicofarmacológico. Conclusão: Dada a complexidade dos quadros clínicos nos casos de comorbilidade, a experiência da consulta de psiquiatria de ligação e da intervenção multidisciplinar revelou-se uma mais valia no tratamento destes doentes, configurando-se como o cenário mais adequado para o tratamento destas patologias.

  14. [Urinary tract infections in a cohort of kidney transplant recipients].

    PubMed

    Bispo, Ana; Fernandes, Milene; Toscano, Cristina; Marques, Teresa; Machado, Domingos; Weigert, André

    2014-01-01

    Introdução: A infeção do trato urinário é a complicação infeciosa mais comum no período pós transplante renal, estando a sua frequência pouco caracterizada na população portuguesa. Este trabalho teve como objetivo determinar a incidência de infeções do trato urinário e infeções do trato urinário recorrentes em transplantados renais. Material e Métodos: Tratou-se de um estudo observacional de coorte retrospetiva, com consulta dos processos clínicos de doentes transplantados entre Janeiro de 2004 e Dezembro de 2005, no Hospital de Santa Cruz, com seguimento durante cinco anos ou até à data de perda de enxerto, morte ou perda de follow-up. Após uma análise descritiva da população, utilizámos testes bivariados para identificação de fatores associados a infeções do trato urinário. Resultados: Em 127 doentes incluídos com seguimento de 593 doentes/ ano, 53 (41,7%) tiveram pelo menos um episódio de infeção do trato urinário e 21 (16,5%) tiveram infeções do trato urinário recorrentes. O género feminino foi o único fator associado com ocorrência de infeções do trato urinário (p < 0,001, OR = 7,08, RR = 2,95) e infeções do trato urinário recorrentes (p < 0,001, OR = 4,66, RR = 2,83). Os agentes etiológicos mais frequentes foram Escherichia coli (51,6%), Klebsiella pneumoniae (15,5%) e Enterobacter spp (9,9%). As infeções do trato urinário não causaram aumento de mortalidade ou perda de enxerto, mas foram a principal causa de internamentos hospitalares. Discussão: Na nossa população, apenas o género feminino foi identificado como fator de risco para o desenvolvimento de infeções do trato urinário, recorrentes ou não. Escherichia coli foi o agente etiológico mais frequente. Conclusão: Apesar das medidas preventivas adotadas, as infeções do trato urinário continuam a ser uma importante causa de morbilidade e de internamentos hospitalares.

  15. Hyperbaric Oxygen Therapy for the Treatment of Fournier's Gangrene: A Review of 34 Cases.

    PubMed

    Rosa, Isabel; Guerreiro, Francisco

    2015-01-01

    Introdução: A gangrena de Fournier é uma infecção necrotizante grave, que pode levar à morte se não for tratada rapidamente. O tratamento baseia-se na combinação do desbridamento cirúrgico, antibioterapia e terapêutica de suporte. A oxigenoterapia hiperbárica surge como adjuvante quer na optimização da oxigenação dos tecidos infetados, quer através da ação bactericida e bacteriostática. Material e Métodos: Foi feita uma revisão dos processos clínicos dos doentes com gangrena de Fournier referenciados ao Centro de Medicina Subaquática e Hiperbárica da Marinha para realizar oxigenoterapia hiperbárica num período de 25 anos. Resultados: Foram tratados 34 doentes. A maioria dos doentes era do género masculino (94,1%) com idade média de 53,7 anos. A diabetes foi a comorbilidade mais frequentemente associada. O foco de infeção mais frequente foi o trato urinário. A taxa de mortalidade foi de 20,8%. Discussão: A diabetes é a comorbilidade mais frequente, sugerindo a diabetes como factor predisponente. A maioria dos doentes falecidos tinham diabetes, todavia não se conseguiu estabelecer correlação entre diabetes e morte. A área de residência dos doentes parece limitar a referenciação ao centro. Conclusões: A gangrena de Fournier, apesar de rara, é uma doença potencialmente fatal, nomeadamente em doentes com comorbilidades como a diabetes. A oxigenoterapia hiperbárica está recomendada como adjuvante à terapêutica convencional e, quando este recurso está disponível, deve ser considerado. São necessários mais estudos para melhor aferir o papel da oxigenoterapia hiperbárica no tratamento desta entidade.

  16. [Teaching human anatomy to the graduation course in Health Sciences of the Lisbon University: five years of a new educational experience].

    PubMed

    Furtado, Ivo A; Gonçalves Ferreira, Ana D; Gonçalves Ferreira, António J

    2013-01-01

    Introdução/Objectivos: Os autores fazem o balanço dos primeiros cinco anos de ensino de Anatomia da Licenciatura em Ciências da Saúde da Universidade de Lisboa.Material e Métodos: Estudaram o desempenho de 408 alunos inscritos na Unidade Curricular de Anatomia (disciplina obrigatória do primeiro semestre) e 29 na Unidade Curricular de Neuroanatomia (disciplina opcional do sexto semestre). Realizaram a análise estatística pelos testes Anova e t de Student.Resultados e Discussão: Houve um afluxo crescente anual de alunos inscritos na Unidade Curricular de Anatomia, um número estável em Neuroanatomia, predomínio claro de alunos do sexo feminino, ratio docente/aluno variável entre 1/9 e 1/17 na Unidade Curricular de Anatomia e 1/8 na Unidade Curricular de Neuroanatomia; elevado número de desistências iniciais (15,69%) em Anatomia; níveis de aprovação de 95,93% na Unidade Curricular de Anatomia e de 100% em Neuroanatomia; tendência de melhoria verificada nos últimos dois anos, com significado estatístico na Unidade Curricular de Anatomia (p = 0,0001) e igual desempenho escolar de alunos de ambos os sexos; índices de satisfação dos alunos de Anatomia, Bom = 71% e Muito Bom = 8%; Neuroanatomia, classificaçãounânime pelos alunos = Muito Bom.Conclusões: Foi uma experiência pedagógica muito positiva. Os autores propõem: o estudo e a prevenção das causas da desistência inicial dos alunos que acedem ao curso, melhoria do ratio docente/discente, possível extensão a um segundo semestre da Unidade Curricular de Anatomia e melhoria das instalações que já estão em curso e que inclui a remodelação e a modernização do teatro anatómico do Instituto de Anatomia da Faculdade de Medicina da Universidade de Lisboa.

  17. Non-Invasive Ventilation in Patients with Heart Failure: A Systematic Review and Meta-Analysis.

    PubMed

    Bittencourt, Hugo Souza; Reis, Helena França Correia Dos; Lima, Melissa Santos; Gomes, Mansueto

    2017-02-01

    ão invasiva, tolerância ao exercício; e os termos livres: pressão positiva em dois níveis nas vias aéreas (BIPAP), pressão positiva contínua em vias aéreas (CPAP), CF e seus correlatos na língua inglesa, com a combinação dos operadores booleanos (AND e OR). A avaliação da qualidade metodológica se deu via escala de PEDro. Foram calculadas as médias ponderadas e o intervalo de confiança (IC) de 95%. Meta-análise foi realizada com software Review Manager versão 5.3 (Colaboração Cochrane). Foram incluídos quatro ensaios clínicos randomizados. Estudos individuais sugerem que a VNI contribuiu para melhora da CF. VNI resultou em melhora na distância do teste de caminhada de seis minutos (TC6) (68,7m 95% IC: 52,6 a 84,9) comparado ao grupo controle. Concluimos que a VNI é uma intervenção que promove efeitos importantes na melhora da CF de pacientes com IC. No entanto, há uma lacuna na literatura de quais são os parâmetros mais adequados para aplicação dessa técnica.

  18. [Clinical and Epidemiological Study of Complicated Infection by Varicella-Zoster Virus in the Pediatric Age].

    PubMed

    Maia, Catarina; Fonseca, Jacinta; Carvalho, Isabel; Santos, Helena; Moreira, Diana

    2015-01-01

    Introdução: Em Portugal, a incidência da infeção complicada por vírus varicela-zoster e respetivos custos é desconhecida. O objetivo deste estudo foi descrever as características clinico-epidemiológicas dos doentes em idade pediátrica internados com o diagnóstico de infeção complicada por vírus varicela-zoster. Material e Métodos: Estudo descritivo, baseado na análise dos processos clínicos dos doentes internados entre janeiro de 1999 e julho de 2013, com diagnóstico de infeção complicada por vírus varicela-zoster. Resultados: Foram internados 94 doentes por infeção complicada a vírus varicela-zoster, dois por reativação de infeção latente. A mediana da idade foi 38 (IQR 18 - 65) meses. As complicações mais frequentes foram as infeciosas (70,2%), destacando-se a sobreinfeção bacteriana da pele/tecido celular subcut'neo (37,2%) e as complicações respiratórias (24,5%). Seguiram-se as complicações neurológicas (19,1%), gastrointestinais (9,6%), hematológicas (5,3%) e osteoarticulares (4,3%). Diagnosticaram-se 38 (40,4%) infeções bacterianas invasivas, seis com bacteriemia. A mediana da idade na admissão foi mais elevada nas complicações imunológicas relativamente às complicações infeciosas. As complicações neurológicas ocorreram preferencialmente em crianças saudáveis, enquanto as complicações infeciosas, nomeadamente as infeções bacterianas invasivas foram mais frequentes nos doentes medicados com ibuprofeno e/ou corticoide. A evolução foi favorável na maioria dos casos. Discussão: As complicações da infeção pelo vírus varicela-zoster ocorreram preferencialmente em idade pré-escolar e doentes saudáveis. As complicações infeciosas, nomeadamente as dermatológicas e respiratórias, foram as mais frequentes, tendo sido verificada associação com a terapêutica prévia com ibuprofeno e /ou corticoide.Conclusão: Estudos multicêntricos deverão ser planeados com o intuito de otimizar e ajustar as

  19. [Schwannoma of the Upper Extremity: Retrospective Analysis of 17 Cases].

    PubMed

    Sá, Ângelo; Nobre Azevedo, Leandro; Cunha, Luísa

    2016-09-01

    Introdução: O schwanoma ou neurilemoma é um tumor benigno dos nervos periféricos e apresenta-se habitualmente como uma lesão única de crescimento indolente, com origem na proliferação das células de Schwann. Representa uma pequena percentagem dos tumores benignos do membro superior, contudo é o mais frequente de origem neural. Apresentamos um estudo retrospectivo de schwanomas do membro superior para estabelecer a abordagem pré-operatória adequada, avaliar a eficácia do tratamento e observar a evolução pós-operatória. Material e Métodos: Revisão de 17 doentes tratados desde 2007 a 2014 com schwanoma do membro superior e caracterização quanto à idade, sexo, localização no membro superior, sinais e sintomas, exames pré-operatórios, diagnóstico histológico e vigilância pós-operatória.Resultados: Observou-se que em quatro dos doentes, o schwanoma se localizava no braço, três no antebraço, quatro no punho e seis na mão ou dedos. Procedeu-se a excisão com ampliação óptica para optimização do resultado funcional final. A enucleação foi realizada sem lesão fascicular em 12 doentes. Por sua vez, em cinco doentes efectuou-se a excisão dos fascículos envolvidos pela massa. No pós-operatório imediato as parestesias surgiram em nove doentes, regredindo em cinco daqueles no período pósoperatório de 12 meses. Um doente evidenciou défice motor do nervo radial, com recuperação parcial aos 12 meses. Discussão: Os schwanomas são tumores raros, de morfologia bem delimitada, que atingem esporadicamente o membro superior. O diagnóstico pré operatório é pouco frequente, pelo que normalmente apenas se estabelece o diagnóstico após a excisão e o estudo histopatológico.Conclusão: Os schwanomas deverão ser equacionados nas hipóteses de diagnóstico dos nódulos subcutâneos associados a sintomas neurológicos. Assim, é importante investigar a presença de parestesias e o sinal de Tinel, característicos desta

  20. Qual o Papel da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos?

    NASA Astrophysics Data System (ADS)

    da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

    2007-08-01

    É amplamente reconhecido que as pessoas em geral têm grande fascínio e interesse pela Astronomia. Por outro lado, o conteúdo dessa área incluído no ensino formal está longe de ser abrangente e suficiente para suprir a demanda. Esse interesse permite aperfeiçoar a divulgação e o ensino não formal de Astronomia através da mídia aliando a adequação do conteúdo à expectativa das pessoas. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros tem introduzido Astronomia desde a pré-escola até o Ensino Médio. Num estudo realizado com 1180 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um formulário contendo questões que abordavam conhecimentos básicos em Astronomia, como foram adquiridos tais conhecimentos e à infra-estrutura da escola. Para 66,1% dos entrevistados o professor já fez alguma apresentação a respeito de Astronomia. O presente estudo revelou também que 54,4% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 18,4% através da televisão e 27,1% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, livros didáticos, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio no meio em que os alunos obtiveram seus conhecimentos astronômicos, a mídia busca não somente sua difusão, mas a disponibilização desse conhecimento de maneira correta, que às vezes, não é atingido, apresentando conceitos sem fundamentação e incorretos. Por outro lado, no dia-a-dia escolar, é comum encontrar professores que vêm para as aulas com concepções prévias, que podem diferir substancialmente das idéias a serem ensinadas, dificultando o aprendizado de futuros conceitos científicos. Uma avaliação criteriosa, avaliando as dificuldades dos professores em determinar o sentido correto dos conceitos e observando a metodologia que utilizam no ensino, poderá proporcionar uma melhor