Sample records for selected spatial section

  1. Spatial analysis and land use regression of VOCs and NO(2) from school-based urban air monitoring in Detroit/Dearborn, USA.

    PubMed

    Mukerjee, Shaibal; Smith, Luther A; Johnson, Mary M; Neas, Lucas M; Stallings, Casson A

    2009-08-01

    Passive ambient air sampling for nitrogen dioxide (NO(2)) and volatile organic compounds (VOCs) was conducted at 25 school and two compliance sites in Detroit and Dearborn, Michigan, USA during the summer of 2005. Geographic Information System (GIS) data were calculated at each of 116 schools. The 25 selected schools were monitored to assess and model intra-urban gradients of air pollutants to evaluate impact of traffic and urban emissions on pollutant levels. Schools were chosen to be statistically representative of urban land use variables such as distance to major roadways, traffic intensity around the schools, distance to nearest point sources, population density, and distance to nearest border crossing. Two approaches were used to investigate spatial variability. First, Kruskal-Wallis analyses and pairwise comparisons on data from the schools examined coarse spatial differences based on city section and distance from heavily trafficked roads. Secondly, spatial variation on a finer scale and as a response to multiple factors was evaluated through land use regression (LUR) models via multiple linear regression. For weeklong exposures, VOCs did not exhibit spatial variability by city section or distance from major roads; NO(2) was significantly elevated in a section dominated by traffic and industrial influence versus a residential section. Somewhat in contrast to coarse spatial analyses, LUR results revealed spatial gradients in NO(2) and selected VOCs across the area. The process used to select spatially representative sites for air sampling and the results of coarse and fine spatial variability of air pollutants provide insights that may guide future air quality studies in assessing intra-urban gradients.

  2. Optimization of the excitation light sheet in selective plane illumination microscopy

    PubMed Central

    Gao, Liang

    2015-01-01

    Selective plane illumination microscopy (SPIM) allows rapid 3D live fluorescence imaging on biological specimens with high 3D spatial resolution, good optical sectioning capability and minimal photobleaching and phototoxic effect. SPIM gains its advantage by confining the excitation light near the detection focal plane, and its performance is determined by the ability to create a thin, large and uniform excitation light sheet. Several methods have been developed to create such an excitation light sheet for SPIM. However, each method has its own strengths and weaknesses, and tradeoffs must be made among different aspects in SPIM imaging. In this work, we present a strategy to select the excitation light sheet among the latest SPIM techniques, and to optimize its geometry based on spatial resolution, field of view, optical sectioning capability, and the sample to be imaged. Besides the light sheets discussed in this work, the proposed strategy is also applicable to estimate the SPIM performance using other excitation light sheets. PMID:25798312

  3. Spatially resolved multicomponent gels

    NASA Astrophysics Data System (ADS)

    Draper, Emily R.; Eden, Edward G. B.; McDonald, Tom O.; Adams, Dave J.

    2015-10-01

    Multicomponent supramolecular systems could be used to prepare exciting new functional materials, but it is often challenging to control the assembly across multiple length scales. Here we report a simple approach to forming patterned, spatially resolved multicomponent supramolecular hydrogels. A multicomponent gel is first formed from two low-molecular-weight gelators and consists of two types of fibre, each formed by only one gelator. One type of fibre in this ‘self-sorted network’ is then removed selectively by a light-triggered gel-to-sol transition. We show that the remaining network has the same mechanical properties as it would have done if it initially formed alone. The selective irradiation of sections of the gel through a mask leads to the formation of patterned multicomponent networks, in which either one or two networks can be present at a particular position with a high degree of spatial control.

  4. Polarization-interference mapping of biological fluids polycrystalline films in differentiation of weak changes of optical anisotropy

    NASA Astrophysics Data System (ADS)

    Ushenko, V. O.; Vanchuliak, O.; Sakhnovskiy, M. Y.; Dubolazov, O. V.; Grygoryshyn, P.; Soltys, I. V.; Olar, O. V.; Antoniv, A.

    2017-09-01

    The theoretical background of the azimuthally stable method of polarization-interference mapping of the histological sections of the biopsy of the prostate tissue on the basis of the spatial frequency selection of the mechanisms of linear and circular birefringence is presented. The diagnostic application of a new correlation parameter - complex degree of mutual anisotropy - is analytically substantiated. The method of measuring coordinate distributions of complex degree of mutual anisotropy with further spatial filtration of their high- and low-frequency components is developed. The interconnections of such distributions with parameters of linear and circular birefringence of prostate tissue histological sections are found. The objective criteria of differentiation of benign and malignant conditions of prostate tissue are determined.

  5. Spatial and temporal demographic variation drives within-season fluctuations in sexual selection.

    PubMed

    Kasumovic, Michael M; Bruce, Matthew J; Andrade, Maydianne C B; Herberstein, Marie E

    2008-09-01

    Our understanding of selection in nature stems mainly from whole-season and cross-sectional estimates of selection gradients. These estimates suggest that selection is relatively constant within, but fluctuates between seasons. However, the strength of selection depends on demographics, and because demographics can vary within seasons, there is a gap in our understanding regarding the extent to which seasonal fluctuations in demographics may cause variation in selection. Here we use two populations of the golden orb-web spider (Nephila plumipes) that differ in density to examine how demographics change within a season and whether there are correlated shifts in selection. We demonstrate that there is within-season variation in sex ratio and density at multiple spatial and temporal scales. This variation led to changes in the competitive challenges that males encountered at different times of the season and was correlated with significant variation in selection gradients on male size and weight between sampling periods. We highlight the importance of understanding the biology of the organism under study to correctly determine the relevant scale in which to examine selection. We also argue that studies may underestimate the true variation in selection by averaging values, leading to misinterpretation of the effect of selection on phenotypic evolution.

  6. Creation of Excitons Excited by Light with a Spatial Mode

    NASA Astrophysics Data System (ADS)

    Syouji, Atsushi; Saito, Shingo; Otomo, Akira

    2017-12-01

    When light is absorbed into matter, its degrees of freedom (i.e., energy, polarization, and phase) are transferred to the matter and conserved. In this study, we demonstrate that elementary excitations in matter, which are one-photon-forbidden transition states, become allowed states because of the phase conservation across the entire cross section of excitation light. In particular, when 1S orthoexcitons of the yellow series in the semiconductor cuprous oxide (Cu2O) were resonantly excited by light with a spatial mode, an increase in the Γ 3 - -phonon-emission peak intensity of the excitons was detected depending on the spatial mode. Using group-theory-based analysis, we show that the irreducible representation of a one-photon-forbidden exciton, which is one of the orthoexcitons, can be transmuted to an allowed state by taking the direct product with the polar vector produced from the spatial mode of the light. Although the transition process of the exciton is locally characterized by the usual quadrupole interaction, the phase conservation at each position at which the sample is irradiated causes the exciton to be in the same spatial-mode state. That causes a change in the transition selection rule. The selection rule relaxation due to the spatial mode of the light was also applied for paraexciton creation.

  7. Modulated-alignment dual-axis (MAD) confocal microscopy for deep optical sectioning in tissues

    PubMed Central

    Leigh, Steven Y.; Chen, Ye; Liu, Jonathan T.C.

    2014-01-01

    A strategy is presented to enable optical-sectioning microscopy with improved contrast and imaging depth using low-power (0.5 - 1 mW) diode laser illumination. This technology combines the inherent strengths of focal-modulation microscopy and dual-axis confocal (DAC) microscopy for rejecting out-of-focus and multiply scattered background light in tissues. The DAC architecture is unique in that it utilizes an intersecting pair of illumination and collection beams to improve the spatial-filtering and optical-sectioning performance of confocal microscopy while focal modulation selectively ‘labels’ in-focus signals via amplitude modulation. Simulations indicate that modulating the spatial alignment of dual-axis beams at a frequency f generates signals from the focal volume of the microscope that are modulated at 2f with minimal modulation of background signals, thus providing nearly an order-of-magnitude improvement in optical-sectioning contrast compared to DAC microscopy alone. Experiments show that 2f lock-in detection enhances contrast and imaging depth within scattering phantoms and fresh tissues. PMID:24940534

  8. Assessment of Lower Missouri River physical aquatic habitat and its use by adult sturgeon (Genus Scaphirhynchus), 2005-07

    USGS Publications Warehouse

    Reuter, Joanna M.; Jacobson, Robert B.; Elliott, Caroline M.; DeLonay, Aaron J.

    2009-01-01

    This report presents an exploratory analysis of habitat availability and use by adult Scaphirhynchus sturgeon on the Lower Missouri River from Gavins Point Dam, South Dakota, to the junction with the Mississippi River. The analysis is based on two main data sources collected from 2005 to 2007: (1) a compilation of 153 reach-scale habitat maps (mean reach length, 2.4 kilometers) derived from boat-collected hydroacoustic data and (2) a sturgeon location dataset from which 378 sturgeon telemetry locations are associated with the maps (within 7 days of the mapping and within 10 percent of the discharge). The report focuses on: (1) longitudinal patterns of geomorphic and hydraulic characteristics revealed by the collection of reach maps; (2) assessment of environmental characteristics at sturgeon locations in the context of the mapped reaches; and (3) consideration of spatial distribution of habitat conditions that sturgeon appear to select. Longitudinal patterns of geomorphology, hydraulics, and associated habitats relate strongly to the engineered state of the river. Reaches within each of the following river sections tended to share similar geomorphic, hydrologic, and hydraulic characteristics: the Minimally Engineered section (Gavins Point Dam to Sioux City, Iowa), the Upstream Channelized section (Sioux City, Iowa, to the junction with the Kansas River), and the Downstream Channelized section (Kansas River to the junction with the Mississippi River). Adult sturgeon occupy nearly the full range of available values for each continuous variable assessed: depth, depth slope, depth-averaged velocity, velocity gradient, and Froude number (a dimensionless number relating velocity to depth). However, in the context of habitat available in a reach, sturgeon tend to select some areas over others. Reproductive female shovelnose sturgeon (Scaphirhynchus platorynchus), in particular, were often found in parts of the reach with one or more of the following characteristics: high velocity gradient, high depth slope, low Froude number, and low (though not necessarily the lowest) depth-averaged velocity. Depths used by sturgeon varied considerably. We explored spatial patterns representing the variable ranges that reproductive female shovelnose sturgeon most strongly and consistently selected by mapping areas within reaches meeting the following criteria: greater than the 80th percentile of depth slope, greater than the 80th percentile of velocity gradient, and less than the 20th percentile of Froude number. Our data exploration indicates that areas meeting these criteria have some predictive value regarding sturgeon habitat selection. Of all sturgeon locations that fall on maps from the same year (sample size = 2,013), about 63 percent fall within about 35 percent of the area where at least one variable meets the above criteria and 18 percent of locations fall within 4 percent of the area where all three variables meet the above criteria. The spatial patterns of these mapped areas show distinct differences among the sections of the Lower Missouri River. For example, the areas of predicted selection exhibit a relatively complex mosaic with multiple interconnected pathways in reaches of the Minimally Engineered section. In contrast, areas of predicted selection are concentrated along the channel margins in reaches of the Upstream Channelized section. Because the patterns described in this report represent habitat use in the context of the available habitat in a highly altered river system, selection may not necessarily indicate preferred habitats or habitats sufficient for reproduction and survival of sturgeon species.

  9. Methods and means of Fourier-Stokes polarimetry and the spatial frequency filtering of phase anisotropy manifestations

    NASA Astrophysics Data System (ADS)

    Novakovskaya, O. Yu.; Ushenko, A. G.; Dubolazov, A. V.; Ushenko, V. A.; Ushenko, Yu. A.; Sakhnovskiy, M. Yu.; Soltys, I. V.; Zhytaryuk, V. H.; Olar, O. V.; Sidor, M.; Gorsky, M. P.

    2016-12-01

    The theoretical background of azimuthally stable method of Jones-matrix mapping of histological sections of biopsy of myocardium tissue on the basis of spatial frequency selection of the mechanisms of linear and circular birefringence is presented. The diagnostic application of a new correlation parameter - complex degree of mutual anisotropy - is analytically substantiated. The method of measuring coordinate distributions of complex degree of mutual anisotropy with further spatial filtration of their high- and low-frequency components is developed. The interconnections of such distributions with parameters of linear and circular birefringence of myocardium tissue histological sections are found. The comparative results of measuring the coordinate distributions of complex degree of mutual anisotropy formed by fibrillar networks of myosin fibrils of myocardium tissue of different necrotic states - dead due to coronary heart disease and acute coronary insufficiency are shown. The values and ranges of change of the statistical (moments of the 1st - 4th order) parameters of complex degree of mutual anisotropy coordinate distributions are studied. The objective criteria of differentiation of cause of death are determined.

  10. The spatial patterns of directional phenotypic selection.

    PubMed

    Siepielski, Adam M; Gotanda, Kiyoko M; Morrissey, Michael B; Diamond, Sarah E; DiBattista, Joseph D; Carlson, Stephanie M

    2013-11-01

    Local adaptation, adaptive population divergence and speciation are often expected to result from populations evolving in response to spatial variation in selection. Yet, we lack a comprehensive understanding of the major features that characterise the spatial patterns of selection, namely the extent of variation among populations in the strength and direction of selection. Here, we analyse a data set of spatially replicated studies of directional phenotypic selection from natural populations. The data set includes 60 studies, consisting of 3937 estimates of selection across an average of five populations. We performed meta-analyses to explore features characterising spatial variation in directional selection. We found that selection tends to vary mainly in strength and less in direction among populations. Although differences in the direction of selection occur among populations they do so where selection is often weakest, which may limit the potential for ongoing adaptive population divergence. Overall, we also found that spatial variation in selection appears comparable to temporal (annual) variation in selection within populations; however, several deficiencies in available data currently complicate this comparison. We discuss future research needs to further advance our understanding of spatial variation in selection. © 2013 John Wiley & Sons Ltd/CNRS.

  11. The Cutplane - A tool for interactive solid modeling

    NASA Technical Reports Server (NTRS)

    Edwards, Laurence; Kessler, William; Leifer, Larry

    1988-01-01

    A geometric modeling system which incorporates a new concept for intuitively and unambiguously specifying and manipulating points or features in three dimensional space is presented. The central concept, the Cutplane, consists of a plane that moves through space under control of a mouse or similar input device. The intersection of the plane and any object is highlighted, and only this highlighted section can be selected for manipulation. Selection is accomplished with a crosshair that is constrained to remain within the plane, so that the relationship between the crosshair and the feature of interest is immediately evident. Although the idea of a section view is not new, previously it has been used as a way to reveal hidden structure, not as a means of manipulating objects or indicating spatial position, as is proposed here.

  12. Raman Imaging in Cell Membranes, Lipid-Rich Organelles, and Lipid Bilayers.

    PubMed

    Syed, Aleem; Smith, Emily A

    2017-06-12

    Raman-based optical imaging is a promising analytical tool for noninvasive, label-free chemical imaging of lipid bilayers and cellular membranes. Imaging using spontaneous Raman scattering suffers from a low intensity that hinders its use in some cellular applications. However, developments in coherent Raman imaging, surface-enhanced Raman imaging, and tip-enhanced Raman imaging have enabled video-rate imaging, excellent detection limits, and nanometer spatial resolution, respectively. After a brief introduction to these commonly used Raman imaging techniques for cell membrane studies, this review discusses selected applications of these modalities for chemical imaging of membrane proteins and lipids. Finally, recent developments in chemical tags for Raman imaging and their applications in the analysis of selected cell membrane components are summarized. Ongoing developments toward improving the temporal and spatial resolution of Raman imaging and small-molecule tags with strong Raman scattering cross sections continue to expand the utility of Raman imaging for diverse cell membrane studies.

  13. Coregistration of Preoperative MRI with Ex Vivo Mesorectal Pathology Specimens to Spatially Map Post-treatment Changes in Rectal Cancer Onto In Vivo Imaging: Preliminary Findings.

    PubMed

    Antunes, Jacob; Viswanath, Satish; Brady, Justin T; Crawshaw, Benjamin; Ros, Pablo; Steele, Scott; Delaney, Conor P; Paspulati, Raj; Willis, Joseph; Madabhushi, Anant

    2018-07-01

    The objective of this study was to develop and quantitatively evaluate a radiology-pathology fusion method for spatially mapping tissue regions corresponding to different chemoradiation therapy-related effects from surgically excised whole-mount rectal cancer histopathology onto preoperative magnetic resonance imaging (MRI). This study included six subjects with rectal cancer treated with chemoradiation therapy who were then imaged with a 3-T T2-weighted MRI sequence, before undergoing mesorectal excision surgery. Excised rectal specimens were sectioned, stained, and digitized as two-dimensional (2D) whole-mount slides. Annotations of residual disease, ulceration, fibrosis, muscularis propria, mucosa, fat, inflammation, and pools of mucin were made by an expert pathologist on digitized slide images. An expert radiologist and pathologist jointly established corresponding 2D sections between MRI and pathology images, as well as identified a total of 10 corresponding landmarks per case (based on visually similar structures) on both modalities (five for driving registration and five for evaluating alignment). We spatially fused the in vivo MRI and ex vivo pathology images using landmark-based registration. This allowed us to spatially map detailed annotations from 2D pathology slides onto corresponding 2D MRI sections. Quantitative assessment of coregistered pathology and MRI sections revealed excellent structural alignment, with an overall deviation of 1.50 ± 0.63 mm across five expert-selected anatomic landmarks (in-plane misalignment of two to three pixels at 0.67- to 1.00-mm spatial resolution). Moreover, the T2-weighted intensity distributions were distinctly different when comparing fibrotic tissue to perirectal fat (as expected), but showed a marked overlap when comparing fibrotic tissue and residual rectal cancer. Our fusion methodology enabled successful and accurate localization of post-treatment effects on in vivo MRI. Copyright © 2018 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  14. Multishot Targeted PROPELLER Magnetic Resonance Imaging: Description of the Technique and Initial Applications

    PubMed Central

    Deng, Jie; Larson, Andrew C.

    2010-01-01

    Objectives To test the feasibility of combining inner-volume imaging (IVI) techniques with conventional multishot periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) techniques for targeted-PROPELLER magnetic resonance imaging. Materials and Methods Perpendicular section-selective gradients for spatially selective excitation and refocusing RF pulses were applied to limit the refocused field-of-view (FOV) along the phase-encoding direction for each rectangular blade image. We performed comparison studies in phantoms and normal volunteers by using targeted-PROPELLER methods for a wide range of imaging applications that commonly use turbo-spin-echo (TSE) approaches (brain, abdominal, vessel wall, cardiac). Results In these initial studies, we demonstrated the feasibility of using targeted-PROPELLER approaches to limit the imaging FOV thereby reducing the number of blades or permitting increased spatial resolution without commensurate increases in scan time. Both phantom and in vivo motion studies demonstrated the potential for more robust regional self-navigated motion correction compared with conventional full FOV PROPELLER methods. Conclusion We demonstrated that the reduced FOV targeted-PROPELLER technique offers the potential for reducing imaging time, increasing spatial resolution, and targeting specific areas for robust regional motion correction. PMID:19465860

  15. Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration

    NASA Astrophysics Data System (ADS)

    Anyz, Jiri; Vyslouzilova, Lenka; Vaculovic, Tomas; Tvrdonova, Michaela; Kanicky, Viktor; Haase, Hajo; Horak, Vratislav; Stepankova, Olga; Heger, Zbynek; Adam, Vojtech

    2017-01-01

    We describe a new procedure for the parallel mapping of selected metals in histologically characterized tissue samples. Mapping is achieved via image registration of digital data obtained from two neighbouring cryosections by scanning the first as a histological sample and subjecting the second to laser ablation inductively coupled plasma mass spectrometry. This computer supported procedure enables determination of the distribution and content of metals of interest directly in the chosen histological zones and represents a substantial improvement over the standard approach, which determines these values in tissue homogenates or whole tissue sections. The potential of the described procedure was demonstrated in a pilot study that analysed Zn and Cu levels in successive development stages of pig melanoma tissue using MeLiM (Melanoma-bearing-Libechov-Minipig) model. We anticipate that the procedure could be useful for a complex understanding of the role that the spatial distribution of metals plays within tissues affected by pathological states including cancer.

  16. Polarization-correlation optical microscopy of anisotropic biological layers

    NASA Astrophysics Data System (ADS)

    Ushenko, A. G.; Dubolazov, A. V.; Ushenko, V. A.; Ushenko, Yu. A.; Sakhnovskiy, M. Y.; Balazyuk, V. N.; Khukhlina, O.; Viligorska, K.; Bykov, A.; Doronin, A.; Meglinski, I.

    2016-09-01

    The theoretical background of azimuthally stable method of Jones-matrix mapping of histological sections of biopsy of myocardium tissue on the basis of spatial frequency selection of the mechanisms of linear and circular birefringence is presented. The diagnostic application of a new correlation parameter - complex degree of mutual anisotropy - is analytically substantiated. The method of measuring coordinate distributions of complex degree of mutual anisotropy with further spatial filtration of their high- and low-frequency components is developed. The interconnections of such distributions with parameters of linear and circular birefringence of myocardium tissue histological sections are found. The comparative results of measuring the coordinate distributions of complex degree of mutual anisotropy formed by fibrillar networks of myosin fibrils of myocardium tissue of different necrotic states - dead due to coronary heart disease and acute coronary insufficiency are shown. The values and ranges of change of the statistical (moments of the 1st - 4th order) parameters of complex degree of mutual anisotropy coordinate distributions are studied. The objective criteria of differentiation of cause of death are determined.

  17. Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration

    PubMed Central

    Anyz, Jiri; Vyslouzilova, Lenka; Vaculovic, Tomas; Tvrdonova, Michaela; Kanicky, Viktor; Haase, Hajo; Horak, Vratislav; Stepankova, Olga; Heger, Zbynek; Adam, Vojtech

    2017-01-01

    We describe a new procedure for the parallel mapping of selected metals in histologically characterized tissue samples. Mapping is achieved via image registration of digital data obtained from two neighbouring cryosections by scanning the first as a histological sample and subjecting the second to laser ablation inductively coupled plasma mass spectrometry. This computer supported procedure enables determination of the distribution and content of metals of interest directly in the chosen histological zones and represents a substantial improvement over the standard approach, which determines these values in tissue homogenates or whole tissue sections. The potential of the described procedure was demonstrated in a pilot study that analysed Zn and Cu levels in successive development stages of pig melanoma tissue using MeLiM (Melanoma-bearing-Libechov-Minipig) model. We anticipate that the procedure could be useful for a complex understanding of the role that the spatial distribution of metals plays within tissues affected by pathological states including cancer. PMID:28071735

  18. Controlling laser emission by selecting crystal orientation

    NASA Astrophysics Data System (ADS)

    Chen, Lijuan; Han, Shujuan; Wang, Zhengping; Wang, Jiyang; Zhang, Huanjin; Yu, Haohai; Han, Shuo; Xu, Xinguang

    2013-01-01

    Based on the anisotropy of laser crystal, we demonstrate a method of adjusting laser emission by selecting crystal orientation. When the light propagating direction varies from a to c axis of Nd:LiGd(MoO4)2 crystal, emission wavelength exhibits a sensitive change of 1061 nm → 1061/1062 + 1068 nm → 1068 nm. The experimental discipline is well explained by a theoretical study of simulating on the spatial distribution of stimulated emission cross-section. This letter manifests that the laser property along non-principal-axis direction is also valuable for research and application, which breaks through the traditional custom of using laser materials processed along principal-axis.

  19. Coarse sediment transport dynamics at three spatial scales of bedrock channel bed complexity

    NASA Astrophysics Data System (ADS)

    Goode, J. R.; Wohl, E.

    2007-12-01

    Rivers incised into bedrock in fold-dominated terrain display a complex bed topography that strongly interacts with local hydraulics to produce spatial differences in bed sediment flux. We used painted tracer clasts to investigate how this complex bed topography influences coarse sediment transport at three spatial scales (reach, cross- section and grain). The study was conducted along the Ocoee River gorge, Tennessee between the TVA Ocoee #3 dam and the 1996 Olympic whitewater course. The bed topography consists of undulating bedrock ribs, which are formed at a consistent strike to the bedding and cleavage of the metagreywake and phyllite substrate. Ribs vary in their orientation to flow (from parallel to oblique) and amplitude among three study reaches. These bedrock ribs create a rough bed topography that substantially alters the local flow field and influences reach- scale roughness. In each reach, 300 tracer clasts were randomly selected from the existing bed material. Tracer clasts were surveyed and transport distances were calculated after five scheduled summer releases and a suite of slightly larger but sporadic winter releases. Transport distances were examined as a function of rib orientation and amplitude (reach scale), spatial proximity to bedrock ribs and standard deviation of the bed elevation (cross- section scale), and whether clasts were hydraulically shielded by surrounding clasts, incorporated in the armour layer, imbricated, and/or existed in a pothole, in addition to size and angularity. At the reach scale, where ribs are parallel to flow, lower reach-scale roughness leads to greater sediment transport capacity, sediment flux and transport distances because transport is uninhibited in the downstream direction. Preliminary results indicate that cross section scale characteristics of bed topography exert a greater control on transport distances than grain size.

  20. Color-selective attention need not be mediated by spatial attention.

    PubMed

    Andersen, Søren K; Müller, Matthias M; Hillyard, Steven A

    2009-06-08

    It is well-established that attention can select stimuli for preferential processing on the basis of non-spatial features such as color, orientation, or direction of motion. Evidence is mixed, however, as to whether feature-selective attention acts by increasing the signal strength of to-be-attended features irrespective of their spatial locations or whether it acts by guiding the spotlight of spatial attention to locations containing the relevant feature. To address this question, we designed a task in which feature-selective attention could not be mediated by spatial selection. Participants observed a display of intermingled dots of two colors, which rapidly and unpredictably changed positions, with the task of detecting brief intervals of reduced luminance of 20% of the dots of one or the other color. Both behavioral indices and electrophysiological measures of steady-state visual evoked potentials showed selectively enhanced processing of the attended-color items. The results demonstrate that feature-selective attention produces a sensory gain enhancement at early levels of the visual cortex that occurs without mediation by spatial attention.

  1. Ultrafast Phase Mapping of Thin-Sections from An Apollo 16 Drive Tube - a New Visualisation of Lunar Regolith

    NASA Technical Reports Server (NTRS)

    Botha, Pieter; Butcher, Alan R.; Horsch, Hana; Rickman, Doug; Wentworth, Susan J.; Schrader, Christian M.; Stoeser, Doug; Benedictus, Aukje; Gottlieb, Paul; McKay, David

    2008-01-01

    Polished thin-sections of samples extracted from Apollo drive tubes provide unique insights into the structure of the Moon's regolith at various landing sites. In particular, they allow the mineralogy and texture of the regolith to be studied as a function of depth. Much has been written about such thin-sections based on optical, SEM and EPMA studies, in terms of their essential petrographic features, but there has been little attempt to quantify these aspects from a spatial perspective. In this study, we report the findings of experimental analysis of two thin-sections (64002, 6019, depth range 5.0 - 8.0 cm & 64001, 6031, depth range 50.0 - 53.1 cm), from a single Apollo 16 drive tube using QEMSCAN . A key feature of the method is phase identification by ultrafast energy dispersive x-ray mapping on a pixel-by-pixel basis. By selecting pixel resolutions ranging from 1 - 5 microns, typically 8,500,000 individual measurement points can be collected on a thin-section. The results we present include false colour digital images of both thin-sections. From these images, information such as phase proportions (major, minor and trace phases), particle textures, packing densities, and particle geometries, has been quantified. Parameters such as porosity and average phase density, which are of geomechanical interest, can also be calculated automatically. This study is part of an on-going investigation into spatial variation of lunar regolith and NASA's ISRU Lunar Simulant Development Project.

  2. Tuning Spatial Profiles of Selection Pressure to Modulate the Evolution of Drug Resistance

    NASA Astrophysics Data System (ADS)

    De Jong, Maxwell G.; Wood, Kevin B.

    2018-06-01

    Spatial heterogeneity plays an important role in the evolution of drug resistance. While recent studies have indicated that spatial gradients of selection pressure can accelerate resistance evolution, much less is known about evolution in more complex spatial profiles. Here we use a stochastic toy model of drug resistance to investigate how different spatial profiles of selection pressure impact the time to fixation of a resistant allele. Using mean first passage time calculations, we show that spatial heterogeneity accelerates resistance evolution when the rate of spatial migration is sufficiently large relative to mutation but slows fixation for small migration rates. Interestingly, there exists an intermediate regime—characterized by comparable rates of migration and mutation—in which the rate of fixation can be either accelerated or decelerated depending on the spatial profile, even when spatially averaged selection pressure remains constant. Finally, we demonstrate that optimal tuning of the spatial profile can dramatically slow the spread and fixation of resistant subpopulations, even in the absence of a fitness cost for resistance. Our results may lay the groundwork for optimized, spatially resolved drug dosing strategies for mitigating the effects of drug resistance.

  3. Landscape moderation of biodiversity patterns and processes - eight hypotheses.

    PubMed

    Tscharntke, Teja; Tylianakis, Jason M; Rand, Tatyana A; Didham, Raphael K; Fahrig, Lenore; Batáry, Péter; Bengtsson, Janne; Clough, Yann; Crist, Thomas O; Dormann, Carsten F; Ewers, Robert M; Fründ, Jochen; Holt, Robert D; Holzschuh, Andrea; Klein, Alexandra M; Kleijn, David; Kremen, Claire; Landis, Doug A; Laurance, William; Lindenmayer, David; Scherber, Christoph; Sodhi, Navjot; Steffan-Dewenter, Ingolf; Thies, Carsten; van der Putten, Wim H; Westphal, Catrin

    2012-08-01

    Understanding how landscape characteristics affect biodiversity patterns and ecological processes at local and landscape scales is critical for mitigating effects of global environmental change. In this review, we use knowledge gained from human-modified landscapes to suggest eight hypotheses, which we hope will encourage more systematic research on the role of landscape composition and configuration in determining the structure of ecological communities, ecosystem functioning and services. We organize the eight hypotheses under four overarching themes. Section A: 'landscape moderation of biodiversity patterns' includes (1) the landscape species pool hypothesis-the size of the landscape-wide species pool moderates local (alpha) biodiversity, and (2) the dominance of beta diversity hypothesis-landscape-moderated dissimilarity of local communities determines landscape-wide biodiversity and overrides negative local effects of habitat fragmentation on biodiversity. Section B: 'landscape moderation of population dynamics' includes (3) the cross-habitat spillover hypothesis-landscape-moderated spillover of energy, resources and organisms across habitats, including between managed and natural ecosystems, influences landscape-wide community structure and associated processes and (4) the landscape-moderated concentration and dilution hypothesis-spatial and temporal changes in landscape composition can cause transient concentration or dilution of populations with functional consequences. Section C: 'landscape moderation of functional trait selection' includes (5) the landscape-moderated functional trait selection hypothesis-landscape moderation of species trait selection shapes the functional role and trajectory of community assembly, and (6) the landscape-moderated insurance hypothesis-landscape complexity provides spatial and temporal insurance, i.e. high resilience and stability of ecological processes in changing environments. Section D: 'landscape constraints on conservation management' includes (7) the intermediate landscape-complexity hypothesis-landscape-moderated effectiveness of local conservation management is highest in structurally simple, rather than in cleared (i.e. extremely simplified) or in complex landscapes, and (8) the landscape-moderated biodiversity versus ecosystem service management hypothesis-landscape-moderated biodiversity conservation to optimize functional diversity and related ecosystem services will not protect endangered species. Shifting our research focus from local to landscape-moderated effects on biodiversity will be critical to developing solutions for future biodiversity and ecosystem service management. © 2012 The Authors. Biological Reviews © 2012 Cambridge Philosophical Society.

  4. Selection of the Maximum Spatial Cluster Size of the Spatial Scan Statistic by Using the Maximum Clustering Set-Proportion Statistic.

    PubMed

    Ma, Yue; Yin, Fei; Zhang, Tao; Zhou, Xiaohua Andrew; Li, Xiaosong

    2016-01-01

    Spatial scan statistics are widely used in various fields. The performance of these statistics is influenced by parameters, such as maximum spatial cluster size, and can be improved by parameter selection using performance measures. Current performance measures are based on the presence of clusters and are thus inapplicable to data sets without known clusters. In this work, we propose a novel overall performance measure called maximum clustering set-proportion (MCS-P), which is based on the likelihood of the union of detected clusters and the applied dataset. MCS-P was compared with existing performance measures in a simulation study to select the maximum spatial cluster size. Results of other performance measures, such as sensitivity and misclassification, suggest that the spatial scan statistic achieves accurate results in most scenarios with the maximum spatial cluster sizes selected using MCS-P. Given that previously known clusters are not required in the proposed strategy, selection of the optimal maximum cluster size with MCS-P can improve the performance of the scan statistic in applications without identified clusters.

  5. Selection of the Maximum Spatial Cluster Size of the Spatial Scan Statistic by Using the Maximum Clustering Set-Proportion Statistic

    PubMed Central

    Ma, Yue; Yin, Fei; Zhang, Tao; Zhou, Xiaohua Andrew; Li, Xiaosong

    2016-01-01

    Spatial scan statistics are widely used in various fields. The performance of these statistics is influenced by parameters, such as maximum spatial cluster size, and can be improved by parameter selection using performance measures. Current performance measures are based on the presence of clusters and are thus inapplicable to data sets without known clusters. In this work, we propose a novel overall performance measure called maximum clustering set–proportion (MCS-P), which is based on the likelihood of the union of detected clusters and the applied dataset. MCS-P was compared with existing performance measures in a simulation study to select the maximum spatial cluster size. Results of other performance measures, such as sensitivity and misclassification, suggest that the spatial scan statistic achieves accurate results in most scenarios with the maximum spatial cluster sizes selected using MCS-P. Given that previously known clusters are not required in the proposed strategy, selection of the optimal maximum cluster size with MCS-P can improve the performance of the scan statistic in applications without identified clusters. PMID:26820646

  6. A Review of the Statistical and Quantitative Methods Used to Study Alcohol-Attributable Crime.

    PubMed

    Fitterer, Jessica L; Nelson, Trisalyn A

    2015-01-01

    Modelling the relationship between alcohol consumption and crime generates new knowledge for crime prevention strategies. Advances in data, particularly data with spatial and temporal attributes, have led to a growing suite of applied methods for modelling. In support of alcohol and crime researchers we synthesized and critiqued existing methods of spatially and quantitatively modelling the effects of alcohol exposure on crime to aid method selection, and identify new opportunities for analysis strategies. We searched the alcohol-crime literature from 1950 to January 2014. Analyses that statistically evaluated or mapped the association between alcohol and crime were included. For modelling purposes, crime data were most often derived from generalized police reports, aggregated to large spatial units such as census tracts or postal codes, and standardized by residential population data. Sixty-eight of the 90 selected studies included geospatial data of which 48 used cross-sectional datasets. Regression was the prominent modelling choice (n = 78) though dependent on data many variations existed. There are opportunities to improve information for alcohol-attributable crime prevention by using alternative population data to standardize crime rates, sourcing crime information from non-traditional platforms (social media), increasing the number of panel studies, and conducting analysis at the local level (neighbourhood, block, or point). Due to the spatio-temporal advances in crime data, we expect a continued uptake of flexible Bayesian hierarchical modelling, a greater inclusion of spatial-temporal point pattern analysis, and shift toward prospective (forecast) modelling over small areas (e.g., blocks).

  7. A Review of the Statistical and Quantitative Methods Used to Study Alcohol-Attributable Crime

    PubMed Central

    Fitterer, Jessica L.; Nelson, Trisalyn A.

    2015-01-01

    Modelling the relationship between alcohol consumption and crime generates new knowledge for crime prevention strategies. Advances in data, particularly data with spatial and temporal attributes, have led to a growing suite of applied methods for modelling. In support of alcohol and crime researchers we synthesized and critiqued existing methods of spatially and quantitatively modelling the effects of alcohol exposure on crime to aid method selection, and identify new opportunities for analysis strategies. We searched the alcohol-crime literature from 1950 to January 2014. Analyses that statistically evaluated or mapped the association between alcohol and crime were included. For modelling purposes, crime data were most often derived from generalized police reports, aggregated to large spatial units such as census tracts or postal codes, and standardized by residential population data. Sixty-eight of the 90 selected studies included geospatial data of which 48 used cross-sectional datasets. Regression was the prominent modelling choice (n = 78) though dependent on data many variations existed. There are opportunities to improve information for alcohol-attributable crime prevention by using alternative population data to standardize crime rates, sourcing crime information from non-traditional platforms (social media), increasing the number of panel studies, and conducting analysis at the local level (neighbourhood, block, or point). Due to the spatio-temporal advances in crime data, we expect a continued uptake of flexible Bayesian hierarchical modelling, a greater inclusion of spatial-temporal point pattern analysis, and shift toward prospective (forecast) modelling over small areas (e.g., blocks). PMID:26418016

  8. An enhanced droplet-based liquid microjunction surface sampling system coupled with HPLC-ESI-MS/MS for spatially resolved analysis

    DOE PAGES

    Van Berkel, Gary J.; Weiskittel, Taylor M.; Kertesz, Vilmos

    2014-11-07

    Droplet-based liquid microjunction surface sampling coupled with high-performance liquid chromatography (HPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) for spatially resolved analysis provides the possibility of effective analysis of complex matrix samples and can provide a greater degree of chemical information from a single spot sample than is typically possible with a direct analysis of an extract. Described here is the setup and enhanced capabilities of a discrete droplet liquid microjunction surface sampling system employing a commercially available CTC PAL autosampler. The system enhancements include incorporation of a laser distance sensor enabling unattended analysis of samples and sample locations of dramatically disparatemore » height as well as reliably dispensing just 0.5 μL of extraction solvent to make the liquid junction to the surface, wherein the extraction spot size was confined to an area about 0.7 mm in diameter; software modifications improving the spatial resolution of sampling spot selection from 1.0 to 0.1 mm; use of an open bed tray system to accommodate samples as large as whole-body rat thin tissue sections; and custom sample/solvent holders that shorten sampling time to approximately 1 min per sample. Lastly, the merit of these new features was demonstrated by spatially resolved sampling, HPLC separation, and mass spectral detection of pharmaceuticals and metabolites from whole-body rat thin tissue sections and razor blade (“crude”) cut mouse tissue.« less

  9. An enhanced droplet-based liquid microjunction surface sampling system coupled with HPLC-ESI-MS/MS for spatially resolved analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Van Berkel, Gary J.; Weiskittel, Taylor M.; Kertesz, Vilmos

    Droplet-based liquid microjunction surface sampling coupled with high-performance liquid chromatography (HPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) for spatially resolved analysis provides the possibility of effective analysis of complex matrix samples and can provide a greater degree of chemical information from a single spot sample than is typically possible with a direct analysis of an extract. Described here is the setup and enhanced capabilities of a discrete droplet liquid microjunction surface sampling system employing a commercially available CTC PAL autosampler. The system enhancements include incorporation of a laser distance sensor enabling unattended analysis of samples and sample locations of dramatically disparatemore » height as well as reliably dispensing just 0.5 μL of extraction solvent to make the liquid junction to the surface, wherein the extraction spot size was confined to an area about 0.7 mm in diameter; software modifications improving the spatial resolution of sampling spot selection from 1.0 to 0.1 mm; use of an open bed tray system to accommodate samples as large as whole-body rat thin tissue sections; and custom sample/solvent holders that shorten sampling time to approximately 1 min per sample. Lastly, the merit of these new features was demonstrated by spatially resolved sampling, HPLC separation, and mass spectral detection of pharmaceuticals and metabolites from whole-body rat thin tissue sections and razor blade (“crude”) cut mouse tissue.« less

  10. Discriminative spatial-frequency-temporal feature extraction and classification of motor imagery EEG: An sparse regression and Weighted Naïve Bayesian Classifier-based approach.

    PubMed

    Miao, Minmin; Zeng, Hong; Wang, Aimin; Zhao, Changsen; Liu, Feixiang

    2017-02-15

    Common spatial pattern (CSP) is most widely used in motor imagery based brain-computer interface (BCI) systems. In conventional CSP algorithm, pairs of the eigenvectors corresponding to both extreme eigenvalues are selected to construct the optimal spatial filter. In addition, an appropriate selection of subject-specific time segments and frequency bands plays an important role in its successful application. This study proposes to optimize spatial-frequency-temporal patterns for discriminative feature extraction. Spatial optimization is implemented by channel selection and finding discriminative spatial filters adaptively on each time-frequency segment. A novel Discernibility of Feature Sets (DFS) criteria is designed for spatial filter optimization. Besides, discriminative features located in multiple time-frequency segments are selected automatically by the proposed sparse time-frequency segment common spatial pattern (STFSCSP) method which exploits sparse regression for significant features selection. Finally, a weight determined by the sparse coefficient is assigned for each selected CSP feature and we propose a Weighted Naïve Bayesian Classifier (WNBC) for classification. Experimental results on two public EEG datasets demonstrate that optimizing spatial-frequency-temporal patterns in a data-driven manner for discriminative feature extraction greatly improves the classification performance. The proposed method gives significantly better classification accuracies in comparison with several competing methods in the literature. The proposed approach is a promising candidate for future BCI systems. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Beyond time and space: The effect of a lateralized sustained attention task and brain stimulation on spatial and selective attention.

    PubMed

    Shalev, Nir; De Wandel, Linde; Dockree, Paul; Demeyere, Nele; Chechlacz, Magdalena

    2017-10-03

    The Theory of Visual Attention (TVA) provides a mathematical formalisation of the "biased competition" account of visual attention. Applying this model to individual performance in a free recall task allows the estimation of 5 independent attentional parameters: visual short-term memory (VSTM) capacity, speed of information processing, perceptual threshold of visual detection; attentional weights representing spatial distribution of attention (spatial bias), and the top-down selectivity index. While the TVA focuses on selection in space, complementary accounts of attention describe how attention is maintained over time, and how temporal processes interact with selection. A growing body of evidence indicates that different facets of attention interact and share common neural substrates. The aim of the current study was to modulate a spatial attentional bias via transfer effects, based on a mechanistic understanding of the interplay between spatial, selective and temporal aspects of attention. Specifically, we examined here: (i) whether a single administration of a lateralized sustained attention task could prime spatial orienting and lead to transferable changes in attentional weights (assigned to the left vs right hemi-field) and/or other attentional parameters assessed within the framework of TVA (Experiment 1); (ii) whether the effects of such spatial-priming on TVA parameters could be further enhanced by bi-parietal high frequency transcranial random noise stimulation (tRNS) (Experiment 2). Our results demonstrate that spatial attentional bias, as assessed within the TVA framework, was primed by sustaining attention towards the right hemi-field, but this spatial-priming effect did not occur when sustaining attention towards the left. Furthermore, we show that bi-parietal high-frequency tRNS combined with the rightward spatial-priming resulted in an increased attentional selectivity. To conclude, we present a novel, theory-driven method for attentional modulation providing important insights into how the spatial and temporal processes in attention interact with attentional selection. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Issues of Authenticity of Spatial Data.

    ERIC Educational Resources Information Center

    McGlamery, Patrick

    This paper discusses the authenticity of digital spatial data. The first section describes three formats for digital spatial data: vector, raster, and thematic. The second section addresses the integrity of spatial data, including six possible formats for the same information: (1) aerial photographic prints, time stamped, primary, remotely sensed…

  13. Visual attention spreads broadly but selects information locally.

    PubMed

    Shioiri, Satoshi; Honjyo, Hajime; Kashiwase, Yoshiyuki; Matsumiya, Kazumichi; Kuriki, Ichiro

    2016-10-19

    Visual attention spreads over a range around the focus as the spotlight metaphor describes. Spatial spread of attentional enhancement and local selection/inhibition are crucial factors determining the profile of the spatial attention. Enhancement and ignorance/suppression are opposite effects of attention, and appeared to be mutually exclusive. Yet, no unified view of the factors has been provided despite their necessity for understanding the functions of spatial attention. This report provides electroencephalographic and behavioral evidence for the attentional spread at an early stage and selection/inhibition at a later stage of visual processing. Steady state visual evoked potential showed broad spatial tuning whereas the P3 component of the event related potential showed local selection or inhibition of the adjacent areas. Based on these results, we propose a two-stage model of spatial attention with broad spread at an early stage and local selection at a later stage.

  14. Search strategy selection in the Morris water maze indicates allocentric map formation during learning that underpins spatial memory formation.

    PubMed

    Rogers, Jake; Churilov, Leonid; Hannan, Anthony J; Renoir, Thibault

    2017-03-01

    Using a Matlab classification algorithm, we demonstrate that a highly salient distal cue array is required for significantly increased likelihoods of spatial search strategy selection during Morris water maze spatial learning. We hypothesized that increased spatial search strategy selection during spatial learning would be the key measure demonstrating the formation of an allocentric map to the escape location. Spatial memory, as indicated by quadrant preference for the area of the pool formally containing the hidden platform, was assessed as the main measure that this allocentric map had formed during spatial learning. Our C57BL/6J wild-type (WT) mice exhibit quadrant preference in the highly salient cue paradigm but not the low, corresponding with a 120% increase in the odds of a spatial search strategy selection during learning. In contrast, quadrant preference remains absent in serotonin 1A receptor (5-HT 1A R) knockout (KO) mice, who exhibit impaired search strategy selection during spatial learning. Additionally, we also aimed to assess the impact of the quality of the distal cue array on the spatial learning curves of both latency to platform and path length using mixed-effect regression models and found no significant associations or interactions. In contrast, we demonstrated that the spatial learning curve for search strategy selection was absent during training in the low saliency paradigm. Therefore, we propose that allocentric search strategy selection during spatial learning is the learning parameter in mice that robustly indicates the formation of a cognitive map for the escape goal location. These results also suggest that both latency to platform and path length spatial learning curves do not discriminate between allocentric and egocentric spatial learning and do not reliably predict spatial memory formation. We also show that spatial memory, as indicated by the absolute time in the quadrant formerly containing the hidden platform alone (without reference to the other areas of the pool), was not sensitive to cue saliency or impaired in 5-HT 1A R KO mice. Importantly, in the absence of a search strategy analysis, this suggests that to establish that the Morris water maze has worked (i.e. control mice have formed an allocentric map to the escape goal location), a measure of quadrant preference needs to be reported to establish spatial memory formation. This has implications for studies that claim hippocampal functioning is impaired using latency to platform or path length differences within the existing Morris water maze literature. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. One-loop gravitational wave spectrum in de Sitter spacetime

    NASA Astrophysics Data System (ADS)

    Fröb, Markus B.; Roura, Albert; Verdaguer, Enric

    2012-08-01

    The two-point function for tensor metric perturbations around de Sitter spacetime including one-loop corrections from massless conformally coupled scalar fields is calculated exactly. We work in the Poincaré patch (with spatially flat sections) and employ dimensional regularization for the renormalization process. Unlike previous studies we obtain the result for arbitrary time separations rather than just equal times. Moreover, in contrast to existing results for tensor perturbations, ours is manifestly invariant with respect to the subgroup of de Sitter isometries corresponding to a simultaneous time translation and rescaling of the spatial coordinates. Having selected the right initial state for the interacting theory via an appropriate iepsilon prescription is crucial for that. Finally, we show that although the two-point function is a well-defined spacetime distribution, the equal-time limit of its spatial Fourier transform is divergent. Therefore, contrary to the well-defined distribution for arbitrary time separations, the power spectrum is strictly speaking ill-defined when loop corrections are included.

  16. Spatial distribution of total phenolic content, enzymatic activities and browning in white yam (Dioscorea rotundata) tubers.

    PubMed

    Graham-Acquaah, Seth; Ayernor, George Sodah; Bediako-Amoa, Betty; Saalia, Firibu Kwesi; Afoakwa, Emmanuel Ohene

    2014-10-01

    Browning in raw and processed yams resulting from enzymes, polyphenol oxidase (PPO) and peroxidase (POD), activities is a major limitation to the industrial utilization of Dioscorea varieties of yams. Two elite cultivars of D. rotundata species were selected to study the spatial distribution of total phenols and enzymes (PPO and POD) activities. The intensities of tissue darkening in fresh yam chips prepared from the tuber sections of cultivars during frozen storage were also studied. Total phenolic content was observed to be highest in the head and mid sections of the cultivars than at the tail end. PPO activity did not have any specific distribution pattern whereas POD activity was found to be more concentrated in the head than in the middle and tail regions. Browning was found to be most intense in the head regions of the two cultivars studied; and was observed to correlate with total phenol and dry matter contents of tubers. Between the two enzymes, POD activity appeared to be more related to browning than PPO.

  17. Automated Liquid Microjunction Surface Sampling-HPLC-MS/MS Analysis of Drugs and Metabolites in Whole-Body Thin Tissue Sections

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kertesz, Vilmos; Van Berkel, Gary J

    A fully automated liquid extraction-based surface sampling system utilizing a commercially available autosampler coupled to high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) detection is reported. Discrete spots selected for droplet-based sampling and automated sample queue generation for both the autosampler and MS were enabled by using in-house developed software. In addition, co-registration of spatially resolved sampling position and HPLC-MS information to generate heatmaps of compounds monitored for subsequent data analysis was also available in the software. The system was evaluated with whole-body thin tissue sections from propranolol dosed rat. The hands-free operation of the system was demonstrated by creating heatmapsmore » of the parent drug and its hydroxypropranolol glucuronide metabolites with 1 mm resolution in the areas of interest. The sample throughput was approximately 5 min/sample defined by the time needed for chromatographic separation. The spatial distributions of both the drug and its metabolites were consistent with previous studies employing other liquid extraction-based surface sampling methodologies.« less

  18. Children's attention to task-relevant information accounts for relations between language and spatial cognition.

    PubMed

    Miller, Hilary E; Simmering, Vanessa R

    2018-08-01

    Children's spatial language reliably predicts their spatial skills, but the nature of this relation is a source of debate. This investigation examined whether the mechanisms accounting for such relations are specific to language use or reflect a domain-general mechanism of selective attention. Experiment 1 examined whether 4-year-olds' spatial skills were predicted by their selective attention or their adaptive language use. Children completed (a) an attention task assessing attention to task-relevant color, size, and location cues; (b) a description task assessing adaptive language use to describe scenes varying in color, size, and location; and (c) three spatial tasks. There was correspondence between the cue types that children attended to and produced across description and attention tasks. Adaptive language use was predicted by both children's attention and task-related language production, suggesting that selective attention underlies skills in using language adaptively. After controlling for age, gender, receptive vocabulary, and adaptive language use, spatial skills were predicted by children's selective attention. The attention score predicted variance in spatial performance previously accounted for by adaptive language use. Experiment 2 followed up on the attention task (Experiment 2a) and description task (Experiment 2b) from Experiment 1 to assess whether performance in the tasks related to selective attention or task-specific demands. Performance in Experiments 2a and 2b paralleled that in Experiment 1, suggesting that the effects in Experiment 1 reflected children's selective attention skills. These findings show that selective attention is a central factor supporting spatial skill development that could account for many effects previously attributed to children's language use. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Metacommunity composition of web-spiders in a fragmented neotropical forest: relative importance of environmental and spatial effects.

    PubMed

    Baldissera, Ronei; Rodrigues, Everton N L; Hartz, Sandra M

    2012-01-01

    The distribution of beta diversity is shaped by factors linked to environmental and spatial control. The relative importance of both processes in structuring spider metacommunities has not yet been investigated in the Atlantic Forest. The variance explained by purely environmental, spatially structured environmental, and purely spatial components was compared for a metacommunity of web spiders. The study was carried out in 16 patches of Atlantic Forest in southern Brazil. Field work was done in one landscape mosaic representing a slight gradient of urbanization. Environmental variables encompassed plot- and patch-level measurements and a climatic matrix, while principal coordinates of neighbor matrices (PCNMs) acted as spatial variables. A forward selection procedure was carried out to select environmental and spatial variables influencing web-spider beta diversity. Variation partitioning was used to estimate the contribution of pure environmental and pure spatial effects and their shared influence on beta-diversity patterns, and to estimate the relative importance of selected environmental variables. Three environmental variables (bush density, land use in the surroundings of patches, and shape of patches) and two spatial variables were selected by forward selection procedures. Variation partitioning revealed that 15% of the variation of beta diversity was explained by a combination of environmental and PCNM variables. Most of this variation (12%) corresponded to pure environmental and spatially environmental structure. The data indicated that (1) spatial legacy was not important in explaining the web-spider beta diversity; (2) environmental predictors explained a significant portion of the variation in web-spider composition; (3) one-third of environmental variation was due to a spatial structure that jointly explains variation in species distributions. We were able to detect important factors related to matrix management influencing the web-spider beta-diversity patterns, which are probably linked to historical deforestation events.

  20. Selection and Inhibition in Infancy: Evidence from the Spatial Negative Priming Paradigm

    ERIC Educational Resources Information Center

    Amso, D.; Johnson, S.P.

    2005-01-01

    We used a spatial negative priming (SNP) paradigm to examine visual selective attention in infants and adults using eye movements as the motor selection measure. In SNP, when a previously ignored location becomes the target to be selected, responses to it are impaired, providing a measure of inhibitory selection. Each trial consisted of a prime…

  1. Spread of cochlear excitation during stimulation with pulsed infrared radiation: inferior colliculus measurements

    NASA Astrophysics Data System (ADS)

    Richter, C.-P.; Rajguru, S. M.; Matic, A. I.; Moreno, E. L.; Fishman, A. J.; Robinson, A. M.; Suh, E.; Walsh, J. T., Jr.

    2011-10-01

    Infrared neural stimulation (INS) has received considerable attention over the last few years. It provides an alternative method to artificially stimulate neurons without electrical current or the introduction of exogenous chromophores. One of the primary benefits of INS could be the improved spatial selectivity when compared with electrical stimulation. In the present study, we have evaluated the spatial selectivity of INS in the acutely damaged cochlea of guinea pigs and compared it to stimulation with acoustic tone pips in normal-hearing animals. The radiation was delivered via a 200 µm diameter optical fiber, which was inserted through a cochleostomy into the scala tympani of the basal cochlear turn. The stimulated section along the cochlear spiral ganglion was estimated from the neural responses recorded from the central nucleus of the inferior colliculus (ICC). ICC responses were recorded in response to cochlear INS using a multichannel penetrating electrode array. Spatial tuning curves (STCs) were constructed from the responses. For INS, approximately 55% of the activation profiles showed a single maximum, ~22% had two maxima and ~13% had multiple maxima. The remaining 10% of the profiles occurred at the limits of the electrode array and could not be classified. The majority of ICC STCs indicated that the spread of activation evoked by optical stimuli is comparable to that produced by acoustic tone pips.

  2. Spatial attention does not require preattentive grouping.

    PubMed

    Vecera, S P; Behrmann, M

    1997-01-01

    Does spatial attention follow a full preattentive analysis of the visual field, or can attention select from ungrouped regions of the visual field? We addressed this question by testing an apperceptive agnosic patient, J. W., in tasks involving both spatial selection and preattentive grouping. Results suggest that J.W. had intact spatial attention: He was faster to detect targets appearing at cued location relative to targets appearing at uncued locations. However, his preattentive processes were severely disrupted. Gestalt grouping and symmetry perception, both thought to involve preattentive processes, were impaired in J. W. Also, he could not use gestalt grouping cues to guide spatial attention. These results suggest that spatial attention is not completely dependent on preattentive grouping processes. We argue that preattentive grouping processes and spatial attention may mutually constrain one another in guiding the attentional selection of visual stimuli but that these 2 processes are isolated from one another.

  3. Relatedness in spatially structured populations with empty sites: An approach based on spatial moment equations.

    PubMed

    Lion, Sébastien

    2009-09-07

    Taking into account the interplay between spatial ecological dynamics and selection is a major challenge in evolutionary ecology. Although inclusive fitness theory has proven to be a very useful tool to unravel the interactions between spatial genetic structuring and selection, applications of the theory usually rely on simplifying demographic assumptions. In this paper, I attempt to bridge the gap between spatial demographic models and kin selection models by providing a method to compute approximations for relatedness coefficients in a spatial model with empty sites. Using spatial moment equations, I provide an approximation of nearest-neighbour relatedness on random regular networks, and show that this approximation performs much better than the ordinary pair approximation. I discuss the connection between the relatedness coefficients I define and those used in population genetics, and sketch some potential extensions of the theory.

  4. Restricted cross-scale habitat selection by American beavers.

    PubMed

    Francis, Robert A; Taylor, Jimmy D; Dibble, Eric; Strickland, Bronson; Petro, Vanessa M; Easterwood, Christine; Wang, Guiming

    2017-12-01

    Animal habitat selection, among other ecological phenomena, is spatially scale dependent. Habitat selection by American beavers Castor canadensis (hereafter, beaver) has been studied at singular spatial scales, but to date no research addresses multi-scale selection. Our objectives were to determine if beaver habitat selection was specialized to semiaquatic habitats and if variables explaining habitat selection are consistent between landscape and fine spatial scales. We built maximum entropy (MaxEnt) models to relate landscape-scale presence-only data to landscape variables, and used generalized linear mixed models to evaluate fine spatial scale habitat selection using global positioning system (GPS) relocation data. Explanatory variables between the landscape and fine spatial scale were compared for consistency. Our findings suggested that beaver habitat selection at coarse (study area) and fine (within home range) scales was congruent, and was influenced by increasing amounts of woody wetland edge density and shrub edge density, and decreasing amounts of open water edge density. Habitat suitability at the landscape scale also increased with decreasing amounts of grass frequency. As territorial, central-place foragers, beavers likely trade-off open water edge density (i.e., smaller non-forested wetlands or lodges closer to banks) for defense and shorter distances to forage and obtain construction material. Woody plants along edges and expanses of open water for predator avoidance may limit beaver fitness and subsequently determine beaver habitat selection.

  5. Restricted cross-scale habitat selection by American beavers

    PubMed Central

    Taylor, Jimmy D; Dibble, Eric; Strickland, Bronson; Petro, Vanessa M; Easterwood, Christine; Wang, Guiming

    2017-01-01

    Abstract Animal habitat selection, among other ecological phenomena, is spatially scale dependent. Habitat selection by American beavers Castor canadensis (hereafter, beaver) has been studied at singular spatial scales, but to date no research addresses multi-scale selection. Our objectives were to determine if beaver habitat selection was specialized to semiaquatic habitats and if variables explaining habitat selection are consistent between landscape and fine spatial scales. We built maximum entropy (MaxEnt) models to relate landscape-scale presence-only data to landscape variables, and used generalized linear mixed models to evaluate fine spatial scale habitat selection using global positioning system (GPS) relocation data. Explanatory variables between the landscape and fine spatial scale were compared for consistency. Our findings suggested that beaver habitat selection at coarse (study area) and fine (within home range) scales was congruent, and was influenced by increasing amounts of woody wetland edge density and shrub edge density, and decreasing amounts of open water edge density. Habitat suitability at the landscape scale also increased with decreasing amounts of grass frequency. As territorial, central-place foragers, beavers likely trade-off open water edge density (i.e., smaller non-forested wetlands or lodges closer to banks) for defense and shorter distances to forage and obtain construction material. Woody plants along edges and expanses of open water for predator avoidance may limit beaver fitness and subsequently determine beaver habitat selection. PMID:29492032

  6. Focusing, Sustaining, and Switching Attention

    DTIC Science & Technology

    2013-09-12

    selective attention . Aim 2. Effects on non-spatial features. We measured whether selective attention to an ongoing target improves with time when...talk]. Shinn-Cunningham BG (2013). "Spatial hearing in rooms: Effects on selective auditory attention and sound localization," Neuroscience for...hypothesis that room reverberation interferes with selective attention , 2) whether selective attention to an ongoing target improves with time when

  7. Mapping the timecourse of goal-directed attention to location and colour in human vision.

    PubMed

    Adams, Rachel C; Chambers, Christopher D

    2012-03-01

    Goal-directed attention prioritises perception of task-relevant stimuli according to location, features, or onset time. In this study we compared the behavioural timecourse of goal-directed selection to locations and colours by varying the stimulus-onset asynchrony (SOA) between cue and target in a strategic cueing paradigm. Participants reported the presence or absence of a target following prior information regarding its location or colour. Results revealed that preparatory selection by colour is more effective at enhancing perceptual sensitivity than selection by location, even though both types of cue provided equivalent overall information. More detailed analysis revealed that this advantage arose due a limitation of spatial attention in maintaining a sufficiently broad focus (>2°) for target detection across multiple stimuli. In contrast, when target stimuli fell within 2° of the spatial attention spotlight, the strategic advantages and speed of spatial and colour attention were equated. Our findings are consistent with the conclusion that, under spatially optimal conditions, prior spatial and colour information are equally proficient at guiding top-down selection. When spatial locations are ambiguous, however, colour-based selection is the more efficient mechanism. Copyright © 2012 Elsevier B.V. All rights reserved.

  8. Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS

    NASA Astrophysics Data System (ADS)

    Vinding, Mads S.; Laustsen, Christoffer; Maximov, Ivan I.; Søgaard, Lise Vejby; Ardenkjær-Larsen, Jan H.; Nielsen, Niels Chr.

    2013-02-01

    Aimed at 13C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-13C]pyruvate on a 4.7 T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.

  9. Attention to Hierarchical Level Influences Attentional Selection of Spatial Scale

    ERIC Educational Resources Information Center

    Flevaris, Anastasia V.; Bentin, Shlomo; Robertson, Lynn C.

    2011-01-01

    Ample evidence suggests that global perception may involve low spatial frequency (LSF) processing and that local perception may involve high spatial frequency (HSF) processing (Shulman, Sullivan, Gish, & Sakoda, 1986; Shulman & Wilson, 1987; Robertson, 1996). It is debated whether SF selection is a low-level mechanism associating global…

  10. The role of density-dependent and -independent processes in spawning habitat selection by salmon in an Arctic riverscape.

    PubMed

    Huntsman, Brock M; Falke, Jeffrey A; Savereide, James W; Bennett, Katrina E

    2017-01-01

    Density-dependent (DD) and density-independent (DI) habitat selection is strongly linked to a species' evolutionary history. Determining the relative importance of each is necessary because declining populations are not always the result of altered DI mechanisms but can often be the result of DD via a reduced carrying capacity. We developed spatially and temporally explicit models throughout the Chena River, Alaska to predict important DI mechanisms that influence Chinook salmon spawning success. We used resource-selection functions to predict suitable spawning habitat based on geomorphic characteristics, a semi-distributed water-and-energy balance hydrologic model to generate stream flow metrics, and modeled stream temperature as a function of climatic variables. Spawner counts were predicted throughout the core and periphery spawning sections of the Chena River from escapement estimates (DD) and DI variables. Additionally, we used isodar analysis to identify whether spawners actively defend spawning habitat or follow an ideal free distribution along the riverscape. Aerial counts were best explained by escapement and reference to the core or periphery, while no models with DI variables were supported in the candidate set. Furthermore, isodar plots indicated habitat selection was best explained by ideal free distributions, although there was strong evidence for active defense of core spawning habitat. Our results are surprising, given salmon commonly defend spawning resources, and are likely due to competition occurring at finer spatial scales than addressed in this study.

  11. The role of density-dependent and –independent processes in spawning habitat selection by salmon in an Arctic riverscape

    DOE PAGES

    Huntsman, Brock M.; Falke, Jeffrey A.; Savereide, James W.; ...

    2017-05-22

    Density-dependent (DD) and density-independent (DI) habitat selection is strongly linked to a species’ evolutionary history. Determining the relative importance of each is necessary because declining populations are not always the result of altered DI mechanisms but can often be the result of DD via a reduced carrying capacity. Here, we developed spatially and temporally explicit models throughout the Chena River, Alaska to predict important DI mechanisms that influence Chinook salmon spawning success. We used resource-selection functions to predict suitable spawning habitat based on geomorphic characteristics, a semi-distributed water-and-energy balance hydrologic model to generate stream flow metrics, and modeled stream temperaturemore » as a function of climatic variables. Spawner counts were predicted throughout the core and periphery spawning sections of the Chena River from escapement estimates (DD) and DI variables. In addition, we used isodar analysis to identify whether spawners actively defend spawning habitat or follow an ideal free distribution along the riverscape. Aerial counts were best explained by escapement and reference to the core or periphery, while no models with DI variables were supported in the candidate set. Moreover, isodar plots indicated habitat selection was best explained by ideal free distributions, although there was strong evidence for active defense of core spawning habitat. These results are surprising, given salmon commonly defend spawning resources, and are likely due to competition occurring at finer spatial scales than addressed in this study.« less

  12. The role of density-dependent and –independent processes in spawning habitat selection by salmon in an Arctic riverscape

    USGS Publications Warehouse

    Huntsman, Brock M.; Falke, Jeffrey A.; Savereide, James W.; Bennett, Katrina E.

    2017-01-01

    Density-dependent (DD) and density-independent (DI) habitat selection is strongly linked to a species’ evolutionary history. Determining the relative importance of each is necessary because declining populations are not always the result of altered DI mechanisms but can often be the result of DD via a reduced carrying capacity. We developed spatially and temporally explicit models throughout the Chena River, Alaska to predict important DI mechanisms that influence Chinook salmon spawning success. We used resource-selection functions to predict suitable spawning habitat based on geomorphic characteristics, a semi-distributed water-and-energy balance hydrologic model to generate stream flow metrics, and modeled stream temperature as a function of climatic variables. Spawner counts were predicted throughout the core and periphery spawning sections of the Chena River from escapement estimates (DD) and DI variables. Additionally, we used isodar analysis to identify whether spawners actively defend spawning habitat or follow an ideal free distribution along the riverscape. Aerial counts were best explained by escapement and reference to the core or periphery, while no models with DI variables were supported in the candidate set. Furthermore, isodar plots indicated habitat selection was best explained by ideal free distributions, although there was strong evidence for active defense of core spawning habitat. Our results are surprising, given salmon commonly defend spawning resources, and are likely due to competition occurring at finer spatial scales than addressed in this study.

  13. 3D fluorescence anisotropy imaging using selective plane illumination microscopy.

    PubMed

    Hedde, Per Niklas; Ranjit, Suman; Gratton, Enrico

    2015-08-24

    Fluorescence anisotropy imaging is a popular method to visualize changes in organization and conformation of biomolecules within cells and tissues. In such an experiment, depolarization effects resulting from differences in orientation, proximity and rotational mobility of fluorescently labeled molecules are probed with high spatial resolution. Fluorescence anisotropy is typically imaged using laser scanning and epifluorescence-based approaches. Unfortunately, those techniques are limited in either axial resolution, image acquisition speed, or by photobleaching. In the last decade, however, selective plane illumination microscopy has emerged as the preferred choice for three-dimensional time lapse imaging combining axial sectioning capability with fast, camera-based image acquisition, and minimal light exposure. We demonstrate how selective plane illumination microscopy can be utilized for three-dimensional fluorescence anisotropy imaging of live cells. We further examined the formation of focal adhesions by three-dimensional time lapse anisotropy imaging of CHO-K1 cells expressing an EGFP-paxillin fusion protein.

  14. Bibliography of spatial interferometry in optical astronomy

    NASA Technical Reports Server (NTRS)

    Gezari, Daniel Y.; Roddier, Francois; Roddier, Claude

    1990-01-01

    The Bibliography of Spatial Interferometry in Optical Astronomy is a guide to the published literature in applications of spatial interferometry techniques to astronomical observations, theory and instrumentation at visible and infrared wavelengths. The key words spatial and optical define the scope of this discipline, distinguishing it from spatial interferometry at radio wavelengths, interferometry in the frequency domain applied to spectroscopy, or more general electro-optics theoretical and laboratory research. The main bibliography is a listing of all technical articles published in the international scientific literature and presented at the major international meetings and workshops attended by the spatial interferometry community. Section B summarizes publications dealing with the basic theoretical concepts and algorithms proposed and applied to optical spatial interferometry and imaging through a turbulent atmosphere. The section on experimental techniques is divided into twelve categories, representing the most clearly identified major areas of experimental research work. Section D, Observations, identifies publications dealing specifically with observations of astronomical sources, in which optical spatial interferometry techniques have been applied.

  15. Raccoon spatial requirements and multi-scale habitat selection within an intensively managed central Appalachian forest

    USGS Publications Warehouse

    Owen, Sheldon F.; Berl, Jacob L.; Edwards, John W.; Ford, W. Mark; Wood, Petra Bohall

    2015-01-01

    We studied a raccoon (Procyon lotor) population within a managed central Appalachian hardwood forest in West Virginia to investigate the effects of intensive forest management on raccoon spatial requirements and habitat selection. Raccoon home-range (95% utilization distribution) and core-area (50% utilization distribution) size differed between sexes with males maintaining larger (2×) home ranges and core areas than females. Home-range and core-area size did not differ between seasons for either sex. We used compositional analysis to quantify raccoon selection of six different habitat types at multiple spatial scales. Raccoons selected riparian corridors (riparian management zones [RMZ]) and intact forests (> 70 y old) at the core-area spatial scale. RMZs likely were used by raccoons because they provided abundant denning resources (i.e., large-diameter trees) as well as access to water. Habitat composition associated with raccoon foraging locations indicated selection for intact forests, riparian areas, and regenerating harvest (stands <10 y old). Although raccoons were able to utilize multiple habitat types for foraging resources, a selection of intact forest and RMZs at multiple spatial scales indicates the need of mature forest (with large-diameter trees) for this species in managed forests in the central Appalachians.

  16. Computer-Aided-Design of the Hydraulic System of Three-Dimensional Cartridge Valve Blocks (Selected Articles)

    DTIC Science & Technology

    1991-03-21

    sectional representation of the spatial figure can be correctly determined. 6 The AutoLisp language system in the AutoCAD software provides the most...softwares are developed on the 32-bit machines and little progress has been reported for the 16-bit machines. Even the AutoCAD is a two-ard-a-half... AutoCAD software as the basis, developed the design package of 3-D cartridge valve blocks on IM PC/AT. To realize the 3-D displaying of cartridge valves

  17. [Location selection for Shenyang urban parks based on GIS and multi-objective location allocation model].

    PubMed

    Zhou, Yuan; Shi, Tie-Mao; Hu, Yuan-Man; Gao, Chang; Liu, Miao; Song, Lin-Qi

    2011-12-01

    Based on geographic information system (GIS) technology and multi-objective location-allocation (LA) model, and in considering of four relatively independent objective factors (population density level, air pollution level, urban heat island effect level, and urban land use pattern), an optimized location selection for the urban parks within the Third Ring of Shenyang was conducted, and the selection results were compared with the spatial distribution of existing parks, aimed to evaluate the rationality of the spatial distribution of urban green spaces. In the location selection of urban green spaces in the study area, the factor air pollution was most important, and, compared with single objective factor, the weighted analysis results of multi-objective factors could provide optimized spatial location selection of new urban green spaces. The combination of GIS technology with LA model would be a new approach for the spatial optimizing of urban green spaces.

  18. Visuospatial selective attention in chickens.

    PubMed

    Sridharan, Devarajan; Ramamurthy, Deepa L; Schwarz, Jason S; Knudsen, Eric I

    2014-05-13

    Voluntary control of attention promotes intelligent, adaptive behaviors by enabling the selective processing of information that is most relevant for making decisions. Despite extensive research on attention in primates, the capacity for selective attention in nonprimate species has never been quantified. Here we demonstrate selective attention in chickens by applying protocols that have been used to characterize visual spatial attention in primates. Chickens were trained to localize and report the vertical position of a target in the presence of task-relevant distracters. A spatial cue, the location of which varied across individual trials, indicated the horizontal, but not vertical, position of the upcoming target. Spatial cueing improved localization performance: accuracy (d') increased and reaction times decreased in a space-specific manner. Distracters severely impaired perceptual performance, and this impairment was greatly reduced by spatial cueing. Signal detection analysis with an "indecision" model demonstrated that spatial cueing significantly increased choice certainty in localizing targets. By contrast, error-aversion certainty (certainty of not making an error) remained essentially constant across cueing protocols, target contrasts, and individuals. The results show that chickens shift spatial attention rapidly and dynamically, following principles of stimulus selection that closely parallel those documented in primates. The findings suggest that the mechanisms that control attention have been conserved through evolution, and establish chickens--a highly visual species that is easily trained and amenable to cutting-edge experimental technologies--as an attractive model for linking behavior to neural mechanisms of selective attention.

  19. The role of the left hemisphere in verbal and spatial reasoning tasks.

    PubMed

    Langdon, D; Warrington, E K

    2000-12-01

    Laterality of reasoning processes have long been a source of investigation. Differing formats of verbal and spatial reasoning tasks have meant it has not been possible to extricate true performance level from artefacts of input and output modalities. The Verbal and Spatial Reasoning Test (VESPAR) offers this opportunity, by virtue of matched sets of verbal and spatial inductive reasoning problems. Two series of 40 patients with unilateral left and right hemisphere lesions were tested on two verbal and two spatial subtests of the VESPAR, together with a battery of baseline tests. The performance of the left and right hemisphere lesion cases was compared with a normal standardisation sample. Whereas only the left hemisphere group failed the verbal sections, both left and right hemisphere groups failed the spatial sections. The influence of aphasia on spatial reasoning was considered to be an incomplete explanation for the failure of the left hemisphere group on the spatial sections. It is concluded that this investigation provides firmer evidence of a crucial role for the left hemisphere in both verbal and spatial abstract reasoning processes.

  20. The modulation of perceptual selection by working memory is dependent on the focus of spatial attention.

    PubMed

    Pan, Yi; Soto, David

    2010-07-09

    Recent research suggests that visual selection can be automatically biased to those stimuli matching the contents of working memory (WM). However, a complete functional account of the interplay between WM and attention remains to be established. In particular, the boundary conditions of the WM effect on selection are unclear. Here, the authors investigate the influence of the focus of spatial attention (i.e., diffused vs. focused) by assessing the effect of spatial precues on attentional capture by WM. Experiments 1 and 2 showed that relative to a neutral condition without memory-matching stimuli, the presence of a memory distractor can trigger attentional capture despite being entirely irrelevant for the attention task but this happened only when the item was actively maintained in WM and not when it was merely repeated. Experiments 3a, 3b and 3c showed that attentional capture by WM can be modulated by endogenous spatial pre-cueing of the incoming target of selection. The authors conclude that WM-driven capture of visual selection is dependent on the focus of spatial attention. Copyright 2009 Elsevier Ltd. All rights reserved.

  1. Automating an integrated spatial data-mining model for landfill site selection

    NASA Astrophysics Data System (ADS)

    Abujayyab, Sohaib K. M.; Ahamad, Mohd Sanusi S.; Yahya, Ahmad Shukri; Ahmad, Siti Zubaidah; Aziz, Hamidi Abdul

    2017-10-01

    An integrated programming environment represents a robust approach to building a valid model for landfill site selection. One of the main challenges in the integrated model is the complicated processing and modelling due to the programming stages and several limitations. An automation process helps avoid the limitations and improve the interoperability between integrated programming environments. This work targets the automation of a spatial data-mining model for landfill site selection by integrating between spatial programming environment (Python-ArcGIS) and non-spatial environment (MATLAB). The model was constructed using neural networks and is divided into nine stages distributed between Matlab and Python-ArcGIS. A case study was taken from the north part of Peninsular Malaysia. 22 criteria were selected to utilise as input data and to build the training and testing datasets. The outcomes show a high-performance accuracy percentage of 98.2% in the testing dataset using 10-fold cross validation. The automated spatial data mining model provides a solid platform for decision makers to performing landfill site selection and planning operations on a regional scale.

  2. Spatial-Resolution Cell Type Proteome Profiling of Cancer Tissue by Fully Integrated Proteomics Technology.

    PubMed

    Xu, Ruilian; Tang, Jun; Deng, Quantong; He, Wan; Sun, Xiujie; Xia, Ligang; Cheng, Zhiqiang; He, Lisheng; You, Shuyuan; Hu, Jintao; Fu, Yuxiang; Zhu, Jian; Chen, Yixin; Gao, Weina; He, An; Guo, Zhengyu; Lin, Lin; Li, Hua; Hu, Chaofeng; Tian, Ruijun

    2018-05-01

    Increasing attention has been focused on cell type proteome profiling for understanding the heterogeneous multicellular microenvironment in tissue samples. However, current cell type proteome profiling methods need large amounts of starting materials which preclude their application to clinical tumor specimens with limited access. Here, by seamlessly combining laser capture microdissection and integrated proteomics sample preparation technology SISPROT, specific cell types in tumor samples could be precisely dissected with single cell resolution and processed for high-sensitivity proteome profiling. Sample loss and contamination due to the multiple transfer steps are significantly reduced by the full integration and noncontact design. H&E staining dyes which are necessary for cell type investigation could be selectively removed by the unique two-stage design of the spintip device. This easy-to-use proteome profiling technology achieved high sensitivity with the identification of more than 500 proteins from only 0.1 mm 2 and 10 μm thickness colon cancer tissue section. The first cell type proteome profiling of four cell types from one colon tumor and surrounding normal tissue, including cancer cells, enterocytes, lymphocytes, and smooth muscle cells, was obtained. 5271, 4691, 4876, and 2140 protein groups were identified, respectively, from tissue section of only 5 mm 2 and 10 μm thickness. Furthermore, spatially resolved proteome distribution profiles of enterocytes, lymphocytes, and smooth muscle cells on the same tissue slices and across four consecutive sections with micrometer distance were successfully achieved. This fully integrated proteomics technology, termed LCM-SISPROT, is therefore promising for spatial-resolution cell type proteome profiling of tumor microenvironment with a minute amount of clinical starting materials.

  3. Dual-task results and the lateralization of spatial orientation: artifact of test selection?

    PubMed

    Bowers, C A; Milham, L M; Price, C

    1998-01-01

    An investigation was conducted to identify the degree to which results regarding the lateralization of spatial orientation among men and women are artifacts of test selection. A dual-task design was used to study possible lateralization differences, providing baseline and dual-task measures of spatial-orientation performance, right- and left-hand tapping, and vocalization of "cat, dog, horse." The Guilford-Zimmerman Test (Guilford & Zimmerman, 1953), the Eliot-Price Test (Eliot & Price, 1976), and the Stumpf-Fay Cube Perspectives Test (Stumpf & Fay, 1983) were the three spatial-orientation tests used to investigate possible artifacts of test selection. Twenty-eight right-handed male and 39 right-handed female undergraduates completed random baseline and dual-task sessions. Analyses indicated no significant sex-related differences in spatial-orientation ability for all three tests. Furthermore, there was no evidence of differential lateralization of spatial orientation between the sexes.

  4. A Neurobehavioral Model of Flexible Spatial Language Behaviors

    PubMed Central

    Lipinski, John; Schneegans, Sebastian; Sandamirskaya, Yulia; Spencer, John P.; Schöner, Gregor

    2012-01-01

    We propose a neural dynamic model that specifies how low-level visual processes can be integrated with higher level cognition to achieve flexible spatial language behaviors. This model uses real-word visual input that is linked to relational spatial descriptions through a neural mechanism for reference frame transformations. We demonstrate that the system can extract spatial relations from visual scenes, select items based on relational spatial descriptions, and perform reference object selection in a single unified architecture. We further show that the performance of the system is consistent with behavioral data in humans by simulating results from 2 independent empirical studies, 1 spatial term rating task and 1 study of reference object selection behavior. The architecture we present thereby achieves a high degree of task flexibility under realistic stimulus conditions. At the same time, it also provides a detailed neural grounding for complex behavioral and cognitive processes. PMID:21517224

  5. Biooptical variability in the Greenland Sea observed with the Multispectral Airborne Radiometer System (MARS)

    NASA Technical Reports Server (NTRS)

    Mueller, James L.; Trees, Charles C.

    1989-01-01

    A site-specific ocean color remote sensing algorithm was developed and used to convert Multispectral Airborne Radiometer System (MARS) spectral radiance measurements to chlorophyll-a concentration profiles along aircraft tracklines in the Greenland Sea. The analysis is described and the results given in graphical or tabular form. Section 2 describes the salient characteristics and history of development of the MARS instrument. Section 3 describes the analyses of MARS flight segments over consolidated sea ice, resulting in a set of altitude dependent ratios used (over water) to estimate radiance reflected by the surface and atmosphere from total radiance measured. Section 4 presents optically weighted pigment concentrations calculated from profile data, and spectral reflectances measured in situ from the top meter of the water column; this data was analyzed to develop an algorithm relating chlorophyll-a concentrations to the ratio of radiance reflectances at 441 and 550 nm (with a selection of coefficients dependent upon whether significant gelvin presence is implied by a low ratio of reflectances at 410 and 550 nm). Section 5 describes the scaling adjustments which were derived to reconcile the MARS upwelled radiance ratios at 410:550 nm and 441:550 nm to in situ reflectance ratios measured simultaneously on the surface. Section 6 graphically presents the locations of MARS data tracklines and positions of the surface monitoring R/V. Section 7 presents stick-plots of MARS tracklines selected to illustrate two-dimensional spatial variability within the box covered by each day's flight. Section 8 presents curves of chlorophyll-a concentration profiles derived from MARS data along survey tracklines. Significant results are summarized in Section 1.

  6. A Gaussian Mixture Model-based continuous Boundary Detection for 3D sensor networks.

    PubMed

    Chen, Jiehui; Salim, Mariam B; Matsumoto, Mitsuji

    2010-01-01

    This paper proposes a high precision Gaussian Mixture Model-based novel Boundary Detection 3D (BD3D) scheme with reasonable implementation cost for 3D cases by selecting a minimum number of Boundary sensor Nodes (BNs) in continuous moving objects. It shows apparent advantages in that two classes of boundary and non-boundary sensor nodes can be efficiently classified using the model selection techniques for finite mixture models; furthermore, the set of sensor readings within each sensor node's spatial neighbors is formulated using a Gaussian Mixture Model; different from DECOMO [1] and COBOM [2], we also formatted a BN Array with an additional own sensor reading to benefit selecting Event BNs (EBNs) and non-EBNs from the observations of BNs. In particular, we propose a Thick Section Model (TSM) to solve the problem of transition between 2D and 3D. It is verified by simulations that the BD3D 2D model outperforms DECOMO and COBOM in terms of average residual energy and the number of BNs selected, while the BD3D 3D model demonstrates sound performance even for sensor networks with low densities especially when the value of the sensor transmission range (r) is larger than the value of Section Thickness (d) in TSM. We have also rigorously proved its correctness for continuous geometric domains and full robustness for sensor networks over 3D terrains.

  7. Automated Verification of Spatial Resolution in Remotely Sensed Imagery

    NASA Technical Reports Server (NTRS)

    Davis, Bruce; Ryan, Robert; Holekamp, Kara; Vaughn, Ronald

    2011-01-01

    Image spatial resolution characteristics can vary widely among sources. In the case of aerial-based imaging systems, the image spatial resolution characteristics can even vary between acquisitions. In these systems, aircraft altitude, speed, and sensor look angle all affect image spatial resolution. Image spatial resolution needs to be verified with estimators that include the ground sample distance (GSD), the modulation transfer function (MTF), and the relative edge response (RER), all of which are key components of image quality, along with signal-to-noise ratio (SNR) and dynamic range. Knowledge of spatial resolution parameters is important to determine if features of interest are distinguishable in imagery or associated products, and to develop image restoration algorithms. An automated Spatial Resolution Verification Tool (SRVT) was developed to rapidly determine the spatial resolution characteristics of remotely sensed aerial and satellite imagery. Most current methods for assessing spatial resolution characteristics of imagery rely on pre-deployed engineered targets and are performed only at selected times within preselected scenes. The SRVT addresses these insufficiencies by finding uniform, high-contrast edges from urban scenes and then using these edges to determine standard estimators of spatial resolution, such as the MTF and the RER. The SRVT was developed using the MATLAB programming language and environment. This automated software algorithm assesses every image in an acquired data set, using edges found within each image, and in many cases eliminating the need for dedicated edge targets. The SRVT automatically identifies high-contrast, uniform edges and calculates the MTF and RER of each image, and when possible, within sections of an image, so that the variation of spatial resolution characteristics across the image can be analyzed. The automated algorithm is capable of quickly verifying the spatial resolution quality of all images within a data set, enabling the appropriate use of those images in a number of applications.

  8. Modality-specificity of Selective Attention Networks.

    PubMed

    Stewart, Hannah J; Amitay, Sygal

    2015-01-01

    To establish the modality specificity and generality of selective attention networks. Forty-eight young adults completed a battery of four auditory and visual selective attention tests based upon the Attention Network framework: the visual and auditory Attention Network Tests (vANT, aANT), the Test of Everyday Attention (TEA), and the Test of Attention in Listening (TAiL). These provided independent measures for auditory and visual alerting, orienting, and conflict resolution networks. The measures were subjected to an exploratory factor analysis to assess underlying attention constructs. The analysis yielded a four-component solution. The first component comprised of a range of measures from the TEA and was labeled "general attention." The third component was labeled "auditory attention," as it only contained measures from the TAiL using pitch as the attended stimulus feature. The second and fourth components were labeled as "spatial orienting" and "spatial conflict," respectively-they were comprised of orienting and conflict resolution measures from the vANT, aANT, and TAiL attend-location task-all tasks based upon spatial judgments (e.g., the direction of a target arrow or sound location). These results do not support our a-priori hypothesis that attention networks are either modality specific or supramodal. Auditory attention separated into selectively attending to spatial and non-spatial features, with the auditory spatial attention loading onto the same factor as visual spatial attention, suggesting spatial attention is supramodal. However, since our study did not include a non-spatial measure of visual attention, further research will be required to ascertain whether non-spatial attention is modality-specific.

  9. High spatial resolution analysis of ferromanganese concretions by LA-ICP-MS†

    PubMed Central

    Axelsson, Mikael D; Rodushkin, Ilia; Baxter, Douglas C; Ingri, Johan; Öhlander, Björn

    2002-01-01

    A procedure was developed for the determination of element distributions in cross-sections of ferromanganese concretions using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The effects of carrier flow rates, rf forward power, ablation energy, ablation spot size, repetition rate and number of shots per point on analyte intensity were studied. It is shown that different carrier gas flow rates are required in order to obtain maximum sensitivities for different groups of elements, thus complicating the optimisation of ICP parameters. On the contrary, LA parameters have very similar effects on almost all elements studied, thus providing a common optimum parameter set for the entire mass range. However, for selected LA parameters, the use of compromise conditions was necessary in order to compensate for relatively slow data acquisition by ICP-MS and maintain high spatial resolution without sacrificing the multielemental capabilities of the technique. Possible variations in ablation efficiency were corrected for mathematically using the sum of Fe and Mn intensities. Quantification by external calibration against matrix-matched standards was successfully used for more than 50 elements. These standards, in the form of pressed pellets (no binder), were prepared in-house using ferromanganese concentrates from a deep-sea nodule reference material as well as from shallow-marine concretions varying in size and having different proportions of three major phases: aluminosilicates, Fe- and Mn-oxyhydroxides. Element concentrations in each standard were determined by means of conventional solution nebulisation ICP-MS following acid digestion. Examples of selected inter-element correlations in distribution patterns along the cross-section of a concretion are given.

  10. Spatial Selection and Local Adaptation Jointly Shape Life-History Evolution during Range Expansion.

    PubMed

    Van Petegem, Katrien H P; Boeye, Jeroen; Stoks, Robby; Bonte, Dries

    2016-11-01

    In the context of climate change and species invasions, range shifts increasingly gain attention because the rates at which they occur in the Anthropocene induce rapid changes in biological assemblages. During range shifts, species experience multiple selection pressures. For poleward expansions in particular, it is difficult to interpret observed evolutionary dynamics because of the joint action of evolutionary processes related to spatial selection and to adaptation toward local climatic conditions. To disentangle the effects of these two processes, we integrated stochastic modeling and data from a common garden experiment, using the spider mite Tetranychus urticae as a model species. By linking the empirical data with those derived form a highly parameterized individual-based model, we infer that both spatial selection and local adaptation contributed to the observed latitudinal life-history divergence. Spatial selection best described variation in dispersal behavior, while variation in development was best explained by adaptation to the local climate. Divergence in life-history traits in species shifting poleward could consequently be jointly determined by contemporary evolutionary dynamics resulting from adaptation to the environmental gradient and from spatial selection. The integration of modeling with common garden experiments provides a powerful tool to study the contribution of these evolutionary processes on life-history evolution during range expansion.

  11. Spatial mapping and prediction of Plasmodium falciparum infection risk among school-aged children in Côte d'Ivoire.

    PubMed

    Houngbedji, Clarisse A; Chammartin, Frédérique; Yapi, Richard B; Hürlimann, Eveline; N'Dri, Prisca B; Silué, Kigbafori D; Soro, Gotianwa; Koudou, Benjamin G; Assi, Serge-Brice; N'Goran, Eliézer K; Fantodji, Agathe; Utzinger, Jürg; Vounatsou, Penelope; Raso, Giovanna

    2016-09-07

    In Côte d'Ivoire, malaria remains a major public health issue, and thus a priority to be tackled. The aim of this study was to identify spatially explicit indicators of Plasmodium falciparum infection among school-aged children and to undertake a model-based spatial prediction of P. falciparum infection risk using environmental predictors. A cross-sectional survey was conducted, including parasitological examinations and interviews with more than 5,000 children from 93 schools across Côte d'Ivoire. A finger-prick blood sample was obtained from each child to determine Plasmodium species-specific infection and parasitaemia using Giemsa-stained thick and thin blood films. Household socioeconomic status was assessed through asset ownership and household characteristics. Children were interviewed for preventive measures against malaria. Environmental data were gathered from satellite images and digitized maps. A Bayesian geostatistical stochastic search variable selection procedure was employed to identify factors related to P. falciparum infection risk. Bayesian geostatistical logistic regression models were used to map the spatial distribution of P. falciparum infection and to predict the infection prevalence at non-sampled locations via Bayesian kriging. Complete data sets were available from 5,322 children aged 5-16 years across Côte d'Ivoire. P. falciparum was the predominant species (94.5 %). The Bayesian geostatistical variable selection procedure identified land cover and socioeconomic status as important predictors for infection risk with P. falciparum. Model-based prediction identified high P. falciparum infection risk in the north, central-east, south-east, west and south-west of Côte d'Ivoire. Low-risk areas were found in the south-eastern area close to Abidjan and the south-central and west-central part of the country. The P. falciparum infection risk and related uncertainty estimates for school-aged children in Côte d'Ivoire represent the most up-to-date malaria risk maps. These tools can be used for spatial targeting of malaria control interventions.

  12. Experiment K305: Quantitative analysis of selected bone parameters. Supplement 3A: Trabecular spacing and orientation in the long bones

    NASA Technical Reports Server (NTRS)

    Judy, M. M.

    1981-01-01

    Values of mean trabecular spacing computed from optical diffraction patterns of 1:1 X-ray micrographs of tibial metaphysis and those obtained by standard image digitization techniques show excellent agreement. Upper limits on values of mean trabecular orientation deduced from diffraction patterns and the images are also in excellent agreement. Values of the ratio of mean trabecular spatial density in a region of 300 micrometers distal to the downwardly directed convexity in the cartilage growth plate to the value adjacent to the plate determined for flight animals sacrificed at recovery were significantly smaller than values for vivarium control animals. No significant differences were found in proximal regions. No significant differences in mean trabecular orientation were detected. Decreased values of trabecular spatial density and of both obsteoblastic activity and trabecular cross-sectional area noted in collateral researches suggest decreased modeling activity under weightlessness.

  13. Spatial-frequency Fourier polarimetry of the complex degree of mutual anisotropy of linear and circular birefringence in the diagnostics of oncological changes in morphological structure of biological tissues

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ushenko, Yu A; Gorskii, M P; Dubolazov, A V

    2012-08-31

    Theory of polarisation-correlation analysis of laser images of histological sections of biopsy material from cervix tissue based on spatial frequency selection of linear and circular birefringence mechanisms is formulated. Comparative results of measuring the coordinate distributions of the complex degree of mutual anisotropy (CDMA), produced by fibrillar networks formed by myosin and collagen fibres of cervix tissue in different pathological conditions, namely, pre-cancer (dysplasia) and cancer (adenocarcinoma), are presented. The values and variation ranges of statistical (moments of the first - fourth order), correlation (excess-autocorrelation functions), and fractal (slopes of approximating curves and dispersion of extrema of logarithmic dependences ofmore » power spectra) parameters of the CDMA coordinate distributions are studied. Objective criteria for pathology diagnostics and differentiation of its severity degree are determined. (image processing)« less

  14. Spatial-frequency Fourier polarimetry of the complex degree of mutual anisotropy of linear and circular birefringence in the diagnostics of oncological changes in morphological structure of biological tissues

    NASA Astrophysics Data System (ADS)

    Ushenko, Yu A.; Gorskii, M. P.; Dubolazov, A. V.; Motrich, A. V.; Ushenko, V. A.; Sidor, M. I.

    2012-08-01

    Theory of polarisation-correlation analysis of laser images of histological sections of biopsy material from cervix tissue based on spatial frequency selection of linear and circular birefringence mechanisms is formulated. Comparative results of measuring the coordinate distributions of the complex degree of mutual anisotropy (CDMA), produced by fibrillar networks formed by myosin and collagen fibres of cervix tissue in different pathological conditions, namely, pre-cancer (dysplasia) and cancer (adenocarcinoma), are presented. The values and variation ranges of statistical (moments of the first — fourth order), correlation (excess-autocorrelation functions), and fractal (slopes of approximating curves and dispersion of extrema of logarithmic dependences of power spectra) parameters of the CDMA coordinate distributions are studied. Objective criteria for pathology diagnostics and differentiation of its severity degree are determined.

  15. Environment-dependent variation in selection on life history across small spatial scales.

    PubMed

    Lange, Rolanda; Monro, Keyne; J Marshall, Dustin

    2016-10-01

    Variation in life-history traits is ubiquitous, even though genetic variation is thought to be depleted by selection. One potential mechanism for the maintenance of trait variation is spatially variable selection. We explored spatial variation in selection in the field for a colonial marine invertebrate that shows phenotypic differences across a depth gradient of only 3 m. Our analysis included life-history traits relating to module size, colony growth, and phenology. Directional selection on colony growth varied in strength across depths, while module size was under directional selection at one depth but not the other. Differences in selection may explain some of the observed phenotypic differentiation among depths for one trait but not another: instead, selection should actually erode the differences observed for this trait. Our results suggest selection is not acting alone to maintain trait variation within and across environments in this system. © 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution.

  16. Spatial attention can modulate unconscious orientation processing.

    PubMed

    Bahrami, Bahador; Carmel, David; Walsh, Vincent; Rees, Geraint; Lavie, Nilli

    2008-01-01

    It has recently been suggested that visual spatial attention can only affect consciously perceived events. We measured the effects of sustained spatial attention on orientation-selective adaptation to gratings, rendered invisible by prolonged interocular suppression. Spatial attention augmented the orientation-selective adaptation to invisible adaptor orientation. The effect of attention was clearest for test stimuli at peri-threshold, intermediate contrast levels, suggesting that previous negative results were due to assessing orientation discrimination at maximum contrast. On the basis of these findings we propose a constrained hypothesis for the difference between neuronal mechanisms of spatial attention in the presence versus absence of awareness.

  17. The evolution of recombination in a heterogeneous environment.

    PubMed Central

    Lenormand, T; Otto, S P

    2000-01-01

    Most models describing the evolution of recombination have focused on the case of a single population, implicitly assuming that all individuals are equally likely to mate and that spatial heterogeneity in selection is absent. In these models, the evolution of recombination is driven by linkage disequilibria generated either by epistatic selection or drift. Models based on epistatic selection show that recombination can be favored if epistasis is negative and weak compared to directional selection and if the recombination modifier locus is tightly linked to the selected loci. In this article, we examine the joint effects of spatial heterogeneity in selection and epistasis on the evolution of recombination. In a model with two patches, each subject to different selection regimes, we consider the cases of mutation-selection and migration-selection balance as well as the spread of beneficial alleles. We find that including spatial heterogeneity extends the range of epistasis over which recombination can be favored. Indeed, recombination can be favored without epistasis, with negative and even with positive epistasis depending on environmental circumstances. The selection pressure acting on recombination-modifier loci is often much stronger with spatial heterogeneity, and even loosely linked modifiers and free linkage may evolve. In each case, predicting whether recombination is favored requires knowledge of both the type of environmental heterogeneity and epistasis, as none of these factors alone is sufficient to predict the outcome. PMID:10978305

  18. High axial resolution imaging system for large volume tissues using combination of inclined selective plane illumination and mechanical sectioning

    PubMed Central

    Zhang, Qi; Yang, Xiong; Hu, Qinglei; Bai, Ke; Yin, Fangfang; Li, Ning; Gang, Yadong; Wang, Xiaojun; Zeng, Shaoqun

    2017-01-01

    To resolve fine structures of biological systems like neurons, it is required to realize microscopic imaging with sufficient spatial resolution in three dimensional systems. With regular optical imaging systems, high lateral resolution is accessible while high axial resolution is hard to achieve in a large volume. We introduce an imaging system for high 3D resolution fluorescence imaging of large volume tissues. Selective plane illumination was adopted to provide high axial resolution. A scientific CMOS working in sub-array mode kept the imaging area in the sample surface, which restrained the adverse effect of aberrations caused by inclined illumination. Plastic embedding and precise mechanical sectioning extended the axial range and eliminated distortion during the whole imaging process. The combination of these techniques enabled 3D high resolution imaging of large tissues. Fluorescent bead imaging showed resolutions of 0.59 μm, 0.47μm, and 0.59 μm in the x, y, and z directions, respectively. Data acquired from the volume sample of brain tissue demonstrated the applicability of this imaging system. Imaging of different depths showed uniform performance where details could be recognized in either the near-soma area or terminal area, and fine structures of neurons could be seen in both the xy and xz sections. PMID:29296503

  19. Altering spatial priority maps via statistical learning of target selection and distractor filtering.

    PubMed

    Ferrante, Oscar; Patacca, Alessia; Di Caro, Valeria; Della Libera, Chiara; Santandrea, Elisa; Chelazzi, Leonardo

    2018-05-01

    The cognitive system has the capacity to learn and make use of environmental regularities - known as statistical learning (SL), including for the implicit guidance of attention. For instance, it is known that attentional selection is biased according to the spatial probability of targets; similarly, changes in distractor filtering can be triggered by the unequal spatial distribution of distractors. Open questions remain regarding the cognitive/neuronal mechanisms underlying SL of target selection and distractor filtering. Crucially, it is unclear whether the two processes rely on shared neuronal machinery, with unavoidable cross-talk, or they are fully independent, an issue that we directly addressed here. In a series of visual search experiments, participants had to discriminate a target stimulus, while ignoring a task-irrelevant salient distractor (when present). We systematically manipulated spatial probabilities of either one or the other stimulus, or both. We then measured performance to evaluate the direct effects of the applied contingent probability distribution (e.g., effects on target selection of the spatial imbalance in target occurrence across locations) as well as its indirect or "transfer" effects (e.g., effects of the same spatial imbalance on distractor filtering across locations). By this approach, we confirmed that SL of both target and distractor location implicitly bias attention. Most importantly, we described substantial indirect effects, with the unequal spatial probability of the target affecting filtering efficiency and, vice versa, the unequal spatial probability of the distractor affecting target selection efficiency across locations. The observed cross-talk demonstrates that SL of target selection and distractor filtering are instantiated via (at least partly) shared neuronal machinery, as further corroborated by strong correlations between direct and indirect effects at the level of individual participants. Our findings are compatible with the notion that both kinds of SL adjust the priority of specific locations within attentional priority maps of space. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Evaluation of focused multipolar stimulation for cochlear implants in long-term deafened cats

    NASA Astrophysics Data System (ADS)

    George, Shefin S.; Wise, Andrew K.; Fallon, James B.; Shepherd, Robert K.

    2015-06-01

    Objective. Focused multipolar (FMP) stimulation has been shown to produce restricted neural activation using intracochlear stimulation in animals with a normal population of spiral ganglion neurons (SGNs). However, in a clinical setting, the widespread loss of SGNs and peripheral fibres following deafness is expected to influence the effectiveness of FMP. Approach. We compared the efficacy of FMP stimulation to both monopolar (MP) and tripolar (TP) stimulation in long-term deafened cat cochleae (n = 8). Unlike our previous study, these cochleae contained <10% of the normal SGN population adjacent to the electrode array. We also evaluated the effect of electrode position on stimulation modes by using either modiolar facing or lateral wall facing half-band electrodes. The spread of neural activity across the inferior colliculus, a major nucleus within the central auditory pathway, was used as a measure of spatial selectivity. Main results. In cochleae with significant SGN degeneration, we observed that FMP and TP stimulation resulted in greater spatial selectivity than MP stimulation (p < 0.001). However, thresholds were significantly higher for FMP and TP stimulation compared to MP stimulation (p < 0.001). No difference between FMP and TP stimulation was found in any measures. The high threshold levels for FMP stimulation was significantly reduced without compromising spatial selectivity by varying the degree of current focusing (referred as ‘partial-FMP’ stimulation). Spatial selectivity of all stimulation modes was unaffected by the electrode position. Finally, spatial selectivity in long-term deafened cochleae was significantly less than that of cochleae with normal SGN population (George S S et al 2014 J. Neural Eng. 11 065003). Significance. The present results indicate that the greater spatial selectivity of FMP and TP stimulation over MP stimulation is maintained in cochleae with significant neural degeneration and is not adversely affected by electrode position. The greater spatial selectivity of FMP and TP stimulation would be expected to result in improved clinical performance.

  1. Frontotemporal Dementia Selectively Impairs Transitive Reasoning About Familiar Spatial Environments

    PubMed Central

    Vartanian, Oshin; Goel, Vinod; Tierney, Michael; Huey, Edward D.; Grafman, Jordan

    2010-01-01

    Although patients with frontotemporal dementia (FTD) are known to exhibit a wide range of cognitive and personality difficulties, some evidence suggests that there may be a degree of selectivity in their reasoning impairments. Based on a recent review of the neuroimaging literature on reasoning, the authors hypothesized that the presence or absence of familiar content may have a selective impact on the reasoning abilities of patients with FTD. Specifically, the authors predicted that patients with frontalvariant FTD would be more impaired when reasoning about transitive arguments involving familiar spatial environments than when reasoning about identical logical arguments involving unfamiliar spatial environments. As predicted, patients with FTD were less accurate than normal controls only when the content of arguments involved familiar spatial environments. These results indicate a degree of selectivity in the cognitive deficits of this patient population and suggest that the frontal-temporal lobe system may play a necessary role in reasoning about familiar material. PMID:19702415

  2. Precise Spatially Selective Photothermolysis Using Modulated Femtosecond Lasers and Real-time Multimodal Microscopy Monitoring.

    PubMed

    Huang, Yimei; Lui, Harvey; Zhao, Jianhua; Wu, Zhenguo; Zeng, Haishan

    2017-01-01

    The successful application of lasers in the treatment of skin diseases and cosmetic surgery is largely based on the principle of conventional selective photothermolysis which relies strongly on the difference in the absorption between the therapeutic target and its surroundings. However, when the differentiation in absorption is not sufficient, collateral damage would occur due to indiscriminate and nonspecific tissue heating. To deal with such cases, we introduce a novel spatially selective photothermolysis method based on multiphoton absorption in which the radiant energy of a tightly focused near-infrared femtosecond laser beam can be directed spatially by aiming the laser focal point to the target of interest. We construct a multimodal optical microscope to perform and monitor the spatially selective photothermolysis. We demonstrate that precise alteration of the targeted tissue is achieved while leaving surrounding tissue intact by choosing appropriate femtosecond laser exposure with multimodal optical microscopy monitoring in real time.

  3. Precise Spatially Selective Photothermolysis Using Modulated Femtosecond Lasers and Real-time Multimodal Microscopy Monitoring

    PubMed Central

    Huang, Yimei; Lui, Harvey; Zhao, Jianhua; Wu, Zhenguo; Zeng, Haishan

    2017-01-01

    The successful application of lasers in the treatment of skin diseases and cosmetic surgery is largely based on the principle of conventional selective photothermolysis which relies strongly on the difference in the absorption between the therapeutic target and its surroundings. However, when the differentiation in absorption is not sufficient, collateral damage would occur due to indiscriminate and nonspecific tissue heating. To deal with such cases, we introduce a novel spatially selective photothermolysis method based on multiphoton absorption in which the radiant energy of a tightly focused near-infrared femtosecond laser beam can be directed spatially by aiming the laser focal point to the target of interest. We construct a multimodal optical microscope to perform and monitor the spatially selective photothermolysis. We demonstrate that precise alteration of the targeted tissue is achieved while leaving surrounding tissue intact by choosing appropriate femtosecond laser exposure with multimodal optical microscopy monitoring in real time. PMID:28255346

  4. Selective memory generalization by spatial patterning of protein synthesis

    PubMed Central

    O’Donnell, Cian; Sejnowski, Terrence J.

    2014-01-01

    Summary Protein synthesis is crucial for both persistent synaptic plasticity and long-term memory. De novo protein expression can be restricted to specific neurons within a population, and to specific dendrites within a single neuron. Despite its ubiquity, the functional benefits of spatial protein regulation for learning are unknown. We used computational modeling to study this problem. We found that spatially patterned protein synthesis can enable selective consolidation of some memories but forgetting of others, even for simultaneous events that are represented by the same neural population. Key factors regulating selectivity include the functional clustering of synapses on dendrites, and the sparsity and overlap of neural activity patterns at the circuit level. Based on these findings we proposed a novel two-step model for selective memory generalization during REM and slow-wave sleep. The pattern-matching framework we propose may be broadly applicable to spatial protein signaling throughout cortex and hippocampus. PMID:24742462

  5. Selective memory generalization by spatial patterning of protein synthesis.

    PubMed

    O'Donnell, Cian; Sejnowski, Terrence J

    2014-04-16

    Protein synthesis is crucial for both persistent synaptic plasticity and long-term memory. De novo protein expression can be restricted to specific neurons within a population, and to specific dendrites within a single neuron. Despite its ubiquity, the functional benefits of spatial protein regulation for learning are unknown. We used computational modeling to study this problem. We found that spatially patterned protein synthesis can enable selective consolidation of some memories but forgetting of others, even for simultaneous events that are represented by the same neural population. Key factors regulating selectivity include the functional clustering of synapses on dendrites, and the sparsity and overlap of neural activity patterns at the circuit level. Based on these findings, we proposed a two-step model for selective memory generalization during REM and slow-wave sleep. The pattern-matching framework we propose may be broadly applicable to spatial protein signaling throughout cortex and hippocampus. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Disentangling the effects of spatial inconsistency of targets and distractors when searching in realistic scenes.

    PubMed

    Spotorno, Sara; Malcolm, George L; Tatler, Benjamin W

    2015-02-10

    Previous research has suggested that correctly placed objects facilitate eye guidance, but also that objects violating spatial associations within scenes may be prioritized for selection and subsequent inspection. We analyzed the respective eye guidance of spatial expectations and target template (precise picture or verbal label) in visual search, while taking into account any impact of object spatial inconsistency on extrafoveal or foveal processing. Moreover, we isolated search disruption due to misleading spatial expectations about the target from the influence of spatial inconsistency within the scene upon search behavior. Reliable spatial expectations and precise target template improved oculomotor efficiency across all search phases. Spatial inconsistency resulted in preferential saccadic selection when guidance by template was insufficient to ensure effective search from the outset and the misplaced object was bigger than the objects consistently placed in the same scene region. This prioritization emerged principally during early inspection of the region, but the inconsistent object also tended to be preferentially fixated overall across region viewing. These results suggest that objects are first selected covertly on the basis of their relative size and that subsequent overt selection is made considering object-context associations processed in extrafoveal vision. Once the object was fixated, inconsistency resulted in longer first fixation duration and longer total dwell time. As a whole, our findings indicate that observed impairment of oculomotor behavior when searching for an implausibly placed target is the combined product of disruption due to unreliable spatial expectations and prioritization of inconsistent objects before and during object fixation. © 2015 ARVO.

  7. Modality-specificity of Selective Attention Networks

    PubMed Central

    Stewart, Hannah J.; Amitay, Sygal

    2015-01-01

    Objective: To establish the modality specificity and generality of selective attention networks. Method: Forty-eight young adults completed a battery of four auditory and visual selective attention tests based upon the Attention Network framework: the visual and auditory Attention Network Tests (vANT, aANT), the Test of Everyday Attention (TEA), and the Test of Attention in Listening (TAiL). These provided independent measures for auditory and visual alerting, orienting, and conflict resolution networks. The measures were subjected to an exploratory factor analysis to assess underlying attention constructs. Results: The analysis yielded a four-component solution. The first component comprised of a range of measures from the TEA and was labeled “general attention.” The third component was labeled “auditory attention,” as it only contained measures from the TAiL using pitch as the attended stimulus feature. The second and fourth components were labeled as “spatial orienting” and “spatial conflict,” respectively—they were comprised of orienting and conflict resolution measures from the vANT, aANT, and TAiL attend-location task—all tasks based upon spatial judgments (e.g., the direction of a target arrow or sound location). Conclusions: These results do not support our a-priori hypothesis that attention networks are either modality specific or supramodal. Auditory attention separated into selectively attending to spatial and non-spatial features, with the auditory spatial attention loading onto the same factor as visual spatial attention, suggesting spatial attention is supramodal. However, since our study did not include a non-spatial measure of visual attention, further research will be required to ascertain whether non-spatial attention is modality-specific. PMID:26635709

  8. Geometric Cues, Reference Frames, and the Equivalence of Experienced-Aligned and Novel-Aligned Views in Human Spatial Memory

    ERIC Educational Resources Information Center

    Kelly, Jonathan W.; Sjolund, Lori A.; Sturz, Bradley R.

    2013-01-01

    Spatial memories are often organized around reference frames, and environmental shape provides a salient cue to reference frame selection. To date, however, the environmental cues responsible for influencing reference frame selection remain relatively unknown. To connect research on reference frame selection with that on orientation via…

  9. Mechanisms of Reference Frame Selection in Spatial Term Use: Computational and Empirical Studies

    ERIC Educational Resources Information Center

    Schultheis, Holger; Carlson, Laura A.

    2017-01-01

    Previous studies have shown that multiple reference frames are available and compete for selection during the use of spatial terms such as "above." However, the mechanisms that underlie the selection process are poorly understood. In the current paper we present two experiments and a comparison of three computational models of selection…

  10. Integrated Web-Based Immersive Exploration of the Coordinated Canyon Experiment Data using Open Source STOQS Software

    NASA Astrophysics Data System (ADS)

    McCann, M. P.; Gwiazda, R.; O'Reilly, T. C.; Maier, K. L.; Lundsten, E. M.; Parsons, D. R.; Paull, C. K.

    2017-12-01

    The Coordinated Canyon Experiment (CCE) in Monterey Submarine Canyon has produced a wealth of oceanographic measurements whose analysis will improve understanding of turbidity current processes. Exploration of this data set, consisting of over 60 parameters from 15 platforms, is facilitated by using the open source Spatial Temporal Oceanographic Query System (STOQS) software (https://github.com/stoqs/stoqs). The Monterey Bay Aquarium Research Institute (MBARI) originally developed STOQS to help manage and visualize upper water column oceanographic measurements, but the generality of its data model permits effective use for any kind of spatial/temporal measurement data. STOQS consists of a PostgreSQL database and server-side Python/Django software; the client-side is jQuery JavaScript supporting AJAX requests to update a single page web application. The User Interface (UI) is optimized to provide a quick overview of data in spatial and temporal dimensions, as well as in parameter, platform, and data value space. A user may zoom into any feature of interest and select it, initiating a filter operation that updates the UI with an overview of all the data in the new filtered selection. When details are desired, radio buttons and checkboxes are selected to generate a number of different types of visualizations. These include color-filled temporal section and line plots, parameter-parameter plots, 2D map plots, and interactive 3D spatial visualizations. The Extensible 3D (X3D) standard and X3DOM JavaScript library provide the technology for presenting animated 3D data directly within the web browser. Most of the oceanographic measurements from the CCE (e.g. mooring mounted ADCP and CTD data) are easily visualized using established methods. However, unified integration and multiparameter display of several concurrently deployed sensors across a network of platforms is a challenge we hope to solve. Moreover, STOQS also allows display of data from a new instrument - the Benthic Event Detector (BED). The BED records 50Hz samples of orientation and acceleration when it moves. These data are converted to the CF-NetCDF format and then loaded into a STOQS database. Using the Spatial-3D view a user may interact with a virtual playback of BED motions, giving new insight into submarine canyon sediment density flows.

  11. Selecting habitat to survive: the impact of road density on survival in a large carnivore.

    PubMed

    Basille, Mathieu; Van Moorter, Bram; Herfindal, Ivar; Martin, Jodie; Linnell, John D C; Odden, John; Andersen, Reidar; Gaillard, Jean-Michel

    2013-01-01

    Habitat selection studies generally assume that animals select habitat and food resources at multiple scales to maximise their fitness. However, animals sometimes prefer habitats of apparently low quality, especially when considering the costs associated with spatially heterogeneous human disturbance. We used spatial variation in human disturbance, and its consequences on lynx survival, a direct fitness component, to test the Hierarchical Habitat Selection hypothesis from a population of Eurasian lynx Lynx lynx in southern Norway. Data from 46 lynx monitored with telemetry indicated that a high proportion of forest strongly reduced the risk of mortality from legal hunting at the home range scale, while increasing road density strongly increased such risk at the finer scale within the home range. We found hierarchical effects of the impact of human disturbance, with a higher road density at a large scale reinforcing its negative impact at a fine scale. Conversely, we demonstrated that lynx shifted their habitat selection to avoid areas with the highest road densities within their home ranges, thus supporting a compensatory mechanism at fine scale enabling lynx to mitigate the impact of large-scale disturbance. Human impact, positively associated with high road accessibility, was thus a stronger driver of lynx space use at a finer scale, with home range characteristics nevertheless constraining habitat selection. Our study demonstrates the truly hierarchical nature of habitat selection, which aims at maximising fitness by selecting against limiting factors at multiple spatial scales, and indicates that scale-specific heterogeneity of the environment is driving individual spatial behaviour, by means of trade-offs across spatial scales.

  12. Computerized stratified random site-selection approaches for design of a ground-water-quality sampling network

    USGS Publications Warehouse

    Scott, J.C.

    1990-01-01

    Computer software was written to randomly select sites for a ground-water-quality sampling network. The software uses digital cartographic techniques and subroutines from a proprietary geographic information system. The report presents the approaches, computer software, and sample applications. It is often desirable to collect ground-water-quality samples from various areas in a study region that have different values of a spatial characteristic, such as land-use or hydrogeologic setting. A stratified network can be used for testing hypotheses about relations between spatial characteristics and water quality, or for calculating statistical descriptions of water-quality data that account for variations that correspond to the spatial characteristic. In the software described, a study region is subdivided into areal subsets that have a common spatial characteristic to stratify the population into several categories from which sampling sites are selected. Different numbers of sites may be selected from each category of areal subsets. A population of potential sampling sites may be defined by either specifying a fixed population of existing sites, or by preparing an equally spaced population of potential sites. In either case, each site is identified with a single category, depending on the value of the spatial characteristic of the areal subset in which the site is located. Sites are selected from one category at a time. One of two approaches may be used to select sites. Sites may be selected randomly, or the areal subsets in the category can be grouped into cells and sites selected randomly from each cell.

  13. Feature-based and spatial attentional selection in visual working memory.

    PubMed

    Heuer, Anna; Schubö, Anna

    2016-05-01

    The contents of visual working memory (VWM) can be modulated by spatial cues presented during the maintenance interval ("retrocues"). Here, we examined whether attentional selection of representations in VWM can also be based on features. In addition, we investigated whether the mechanisms of feature-based and spatial attention in VWM differ with respect to parallel access to noncontiguous locations. In two experiments, we tested the efficacy of valid retrocues relying on different kinds of information. Specifically, participants were presented with a typical spatial retrocue pointing to two locations, a symbolic spatial retrocue (numbers mapping onto two locations), and two feature-based retrocues: a color retrocue (a blob of the same color as two of the items) and a shape retrocue (an outline of the shape of two of the items). The two cued items were presented at either contiguous or noncontiguous locations. Overall retrocueing benefits, as compared to a neutral condition, were observed for all retrocue types. Whereas feature-based retrocues yielded benefits for cued items presented at both contiguous and noncontiguous locations, spatial retrocues were only effective when the cued items had been presented at contiguous locations. These findings demonstrate that attentional selection and updating in VWM can operate on different kinds of information, allowing for a flexible and efficient use of this limited system. The observation that the representations of items presented at noncontiguous locations could only be reliably selected with feature-based retrocues suggests that feature-based and spatial attentional selection in VWM rely on different mechanisms, as has been shown for attentional orienting in the external world.

  14. Spatial processes decouple management from objectives in a heterogeneous landscape: predator control as a case study.

    PubMed

    Mahoney, Peter J; Young, Julie K; Hersey, Kent R; Larsen, Randy T; McMillan, Brock R; Stoner, David C

    2018-04-01

    Predator control is often implemented with the intent of disrupting top-down regulation in sensitive prey populations. However, ambiguity surrounding the efficacy of predator management, as well as the strength of top-down effects of predators in general, is often exacerbated by the spatially implicit analytical approaches used in assessing data with explicit spatial structure. Here, we highlight the importance of considering spatial context in the case of a predator control study in south-central Utah. We assessed the spatial match between aerial removal risk in coyotes (Canis latrans) and mule deer (Odocoileus hemionus) resource selection during parturition using a spatially explicit, multi-level Bayesian model. With our model, we were able to evaluate spatial congruence between management action (i.e., coyote removal) and objective (i.e., parturient deer site selection) at two distinct scales: the level of the management unit and the individual coyote removal. In the case of the former, our results indicated substantial spatial heterogeneity in expected congruence between removal risk and parturient deer site selection across large areas, and is a reflection of logistical constraints acting on the management strategy and differences in space use between the two species. At the level of the individual removal, we demonstrated that the potential management benefits of a removed coyote were highly variable across all individuals removed and in many cases, spatially distinct from parturient deer resource selection. Our methods and results provide a means of evaluating where we might anticipate an impact of predator control, while emphasizing the need to weight individual removals based on spatial proximity to management objectives in any assessment of large-scale predator control. Although we highlight the importance of spatial context in assessments of predator control strategy, we believe our methods are readily generalizable in any management or large-scale experimental framework where spatial context is likely an important driver of outcomes. © 2018 by the Ecological Society of America.

  15. Nonparametric Bayesian models for a spatial covariance.

    PubMed

    Reich, Brian J; Fuentes, Montserrat

    2012-01-01

    A crucial step in the analysis of spatial data is to estimate the spatial correlation function that determines the relationship between a spatial process at two locations. The standard approach to selecting the appropriate correlation function is to use prior knowledge or exploratory analysis, such as a variogram analysis, to select the correct parametric correlation function. Rather that selecting a particular parametric correlation function, we treat the covariance function as an unknown function to be estimated from the data. We propose a flexible prior for the correlation function to provide robustness to the choice of correlation function. We specify the prior for the correlation function using spectral methods and the Dirichlet process prior, which is a common prior for an unknown distribution function. Our model does not require Gaussian data or spatial locations on a regular grid. The approach is demonstrated using a simulation study as well as an analysis of California air pollution data.

  16. Selection in spatial working memory is independent of perceptual selective attention, but they interact in a shared spatial priority map.

    PubMed

    Hedge, Craig; Oberauer, Klaus; Leonards, Ute

    2015-11-01

    We examined the relationship between the attentional selection of perceptual information and of information in working memory (WM) through four experiments, using a spatial WM-updating task. Participants remembered the locations of two objects in a matrix and worked through a sequence of updating operations, each mentally shifting one dot to a new location according to an arrow cue. Repeatedly updating the same object in two successive steps is typically faster than switching to the other object; this object switch cost reflects the shifting of attention in WM. In Experiment 1, the arrows were presented in random peripheral locations, drawing perceptual attention away from the selected object in WM. This manipulation did not eliminate the object switch cost, indicating that the mechanisms of perceptual selection do not underlie selection in WM. Experiments 2a and 2b corroborated the independence of selection observed in Experiment 1, but showed a benefit to reaction times when the placement of the arrow cue was aligned with the locations of relevant objects in WM. Experiment 2c showed that the same benefit also occurs when participants are not able to mark an updating location through eye fixations. Together, these data can be accounted for by a framework in which perceptual selection and selection in WM are separate mechanisms that interact through a shared spatial priority map.

  17. Coding of spatial attention priorities and object features in the macaque lateral intraparietal cortex.

    PubMed

    Levichkina, Ekaterina; Saalmann, Yuri B; Vidyasagar, Trichur R

    2017-03-01

    Primate posterior parietal cortex (PPC) is known to be involved in controlling spatial attention. Neurons in one part of the PPC, the lateral intraparietal area (LIP), show enhanced responses to objects at attended locations. Although many are selective for object features, such as the orientation of a visual stimulus, it is not clear how LIP circuits integrate feature-selective information when providing attentional feedback about behaviorally relevant locations to the visual cortex. We studied the relationship between object feature and spatial attention properties of LIP cells in two macaques by measuring the cells' orientation selectivity and the degree of attentional enhancement while performing a delayed match-to-sample task. Monkeys had to match both the location and orientation of two visual gratings presented separately in time. We found a wide range in orientation selectivity and degree of attentional enhancement among LIP neurons. However, cells with significant attentional enhancement had much less orientation selectivity in their response than cells which showed no significant modulation by attention. Additionally, orientation-selective cells showed working memory activity for their preferred orientation, whereas cells showing attentional enhancement also synchronized with local neuronal activity. These results are consistent with models of selective attention incorporating two stages, where an initial feature-selective process guides a second stage of focal spatial attention. We suggest that LIP contributes to both stages, where the first stage involves orientation-selective LIP cells that support working memory of the relevant feature, and the second stage involves attention-enhanced LIP cells that synchronize to provide feedback on spatial priorities. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  18. Selective deficit of spatial short-term memory: Role of storage and rehearsal mechanisms.

    PubMed

    Bonnì, Sonia; Perri, Roberta; Fadda, Lucia; Tomaiuolo, Francesco; Koch, Giacomo; Caltagirone, Carlo; Carlesimo, Giovanni Augusto

    2014-10-01

    We report the neuropsychological and MRI investigation of a patient (GP) who developed a selective impairment of spatial short-term memory (STM) following damage to the dorso-mesial areas of the right frontal lobe. We assessed in this patient spatial STM with an experimental procedure that evaluated immediate and 5-20 s delayed recall of verbal, visual and spatial stimuli. The patient scored significantly worse than normal controls on tests that required delayed recall of spatial data. This could not be ascribed to a deficit of spatial episodic long-term memory because amnesic patients performed normally on these tests. Conversely, the patient scored in the normal range on tests of immediate recall of verbal, visual and spatial data and tests of delayed recall of verbal and visual data. Comparison with a previously described patient who had a selective deficit in immediate spatial recall and an ischemic lesion that affected frontal and parietal dorso-mesial areas in the right hemisphere (Carlesimo GA, Perri R, Turriziani P, Tomaiuolo F, Caltagirone C. Remembering what but not where: independence of spatial and visual working memory in the human brain. Cortex. 2001 Sep; 37(4):519-34) suggests that the right parietal areas are involved in the short-term storage of spatial information and that the dorso-mesial regions of the right frontal underlie mechanisms for the delayed maintenance of the same data.

  19. Spatial accessibility to physical activity facilities and to food outlets and overweight in French youth.

    PubMed

    Casey, R; Chaix, B; Weber, C; Schweitzer, B; Charreire, H; Salze, P; Badariotti, D; Banos, A; Oppert, J-M; Simon, C

    2012-07-01

    Some characteristics of the built environment have been associated with obesity in youth. Our aim was to determine whether individual and environmental socio-economic characteristics modulate the relation between youth overweight and spatial accessibility to physical activity (PA) facilities and to food outlets. Cross-sectional study. 3293 students, aged 12 ± 0.6 years, randomly selected from eastern France middle schools. Using geographical information systems (GIS), spatial accessibility to PA facilities (urban and nature) was assessed using the distance to PA facilities at the municipality level; spatial accessibility to food outlets (general food outlets, bakeries and fast-food outlets) was calculated at individual level using the student home address and the food outlets addresses. Relations of weight status with spatial accessibility to PA facilities and to food outlets were analysed using mixed logistic models, testing potential direct and interaction effects of individual and environmental socio-economic characteristics. Individual socio-economic status modulated the relation between spatial accessibility to PA facilities and to general food outlets and overweight. The likelihood of being overweight was higher when spatial accessibility to urban PA facilities and to general food outlets was low, but in children of blue-collar-workers only. The odds ratio (OR) (95% confidence interval) for being overweight of blue-collar-workers children compared with non-blue-collar-workers children was 1.76 (1.25-2.49) when spatial accessibility to urban PA facilities was low. This OR was 1.86 (1.20-2.86) when spatial accessibility to general food outlets was low. There was no significant relationship of overweight with either nature PA facilities or other food outlets (bakeries and fast-food outlets). These results indicate that disparities in spatial accessibility to PA facilities and to general food outlets may amplify the risk of overweight in socio-economically disadvantaged youth. These data should be relevant for influencing health policies and urban planning at both a national and local level.

  20. Deadlines in space: Selective effects of coordinate spatial processing in multitasking.

    PubMed

    Todorov, Ivo; Del Missier, Fabio; Konke, Linn Andersson; Mäntylä, Timo

    2015-11-01

    Many everyday activities require coordination and monitoring of multiple deadlines. One way to handle these temporal demands might be to represent future goals and deadlines as a pattern of spatial relations. We examined the hypothesis that spatial ability, in addition to executive functioning, contributes to individual differences in multitasking. In two studies, participants completed a multitasking session in which they monitored four digital clocks running at different rates. In Study 1, we found that individual differences in spatial ability and executive functions were independent predictors of multiple-task performance. In Study 2, we found that individual differences in specific spatial abilities were selectively related to multiple-task performance, as only coordinate spatial processing, but not categorical, predicted multitasking, even beyond executive functioning and numeracy. In both studies, males outperformed females in spatial ability and multitasking and in Study 2 these sex differences generalized to a simulation of everyday multitasking. Menstrual changes moderated the effects on multitasking, in that sex differences in coordinate spatial processing and multitasking were observed between males and females in the luteal phase of the menstrual cycle, but not between males and females at menses. Overall, these findings suggest that multiple-task performance reflects independent contributions of spatial ability and executive functioning. Furthermore, our results support the distinction of categorical versus coordinate spatial processing, and suggest that these two basic relational processes are selectively affected by female sex hormones and differentially effective in transforming and handling temporal patterns as spatial relations in the context of multitasking.

  1. Using a cross section to train veterinary students to visualize anatomical structures in three dimensions

    NASA Astrophysics Data System (ADS)

    Provo, Judy; Lamar, Carlton; Newby, Timothy

    2002-01-01

    A cross section was used to enhance three-dimensional knowledge of anatomy of the canine head. All veterinary students in two successive classes (n = 124) dissected the head; experimental groups also identified structures on a cross section of the head. A test assessing spatial knowledge of the head generated 10 dependent variables from two administrations. The test had content validity and statistically significant interrater and test-retest reliability. A live-dog examination generated one additional dependent variable. Analysis of covariance controlling for performance on course examinations and quizzes revealed no treatment effect. Including spatial skill as a third covariate revealed a statistically significant effect of spatial skill on three dependent variables. Men initially had greater spatial skill than women, but spatial skills were equal after 8 months. A qualitative analysis showed the positive impact of this experience on participants. Suggestions for improvement and future research are discussed.

  2. Spatially balanced survey designs for natural resources

    EPA Science Inventory

    Ecological resource monitoring programs typically require the use of a probability survey design to select locations or entities to be physically sampled in the field. The ecological resource of interest, the target population, occurs over a spatial domain and the sample selecte...

  3. Habitat selection by Forster's Terns (Sterna forsteri) at multiple spatial scales in an urbanized estuary: The importance of salt ponds

    USGS Publications Warehouse

    Bluso-Demers, Jill; Ackerman, Joshua T.; Takekawa, John Y.; Peterson, Sarah

    2016-01-01

    The highly urbanized San Francisco Bay Estuary, California, USA, is currently undergoing large-scale habitat restoration, and several thousand hectares of former salt evaporation ponds are being converted to tidal marsh. To identify potential effects of this habitat restoration on breeding waterbirds, habitat selection of radiotagged Forster's Terns (Sterna forsteri) was examined at multiple spatial scales during the pre-breeding and breeding seasons of 2005 and 2006. At each spatial scale, habitat selection ratios were calculated by season, year, and sex. Forster's Terns selected salt pond habitats at most spatial scales and demonstrated the importance of salt ponds for foraging and roosting. Salinity influenced the types of salt pond habitats that were selected. Specifically, Forster's Terns strongly selected lower salinity salt ponds (0.5–30 g/L) and generally avoided higher salinity salt ponds (≥31 g/L). Forster's Terns typically used tidal marsh and managed marsh habitats in proportion to their availability, avoided upland and tidal flat habitats, and strongly avoided open bay habitats. Salt ponds provide important habitat for breeding waterbirds, and restoration efforts to convert former salt ponds to tidal marsh may reduce the availability of preferred breeding and foraging areas.

  4. Urban Rain Gauge Siting Selection Based on Gis-Multicriteria Analysis

    NASA Astrophysics Data System (ADS)

    Fu, Yanli; Jing, Changfeng; Du, Mingyi

    2016-06-01

    With the increasingly rapid growth of urbanization and climate change, urban rainfall monitoring as well as urban waterlogging has widely been paid attention. In the light of conventional siting selection methods do not take into consideration of geographic surroundings and spatial-temporal scale for the urban rain gauge site selection, this paper primarily aims at finding the appropriate siting selection rules and methods for rain gauge in urban area. Additionally, for optimization gauge location, a spatial decision support system (DSS) aided by geographical information system (GIS) has been developed. In terms of a series of criteria, the rain gauge optimal site-search problem can be addressed by a multicriteria decision analysis (MCDA). A series of spatial analytical techniques are required for MCDA to identify the prospective sites. With the platform of GIS, using spatial kernel density analysis can reflect the population density; GIS buffer analysis is used to optimize the location with the rain gauge signal transmission character. Experiment results show that the rules and the proposed method are proper for the rain gauge site selection in urban areas, which is significant for the siting selection of urban hydrological facilities and infrastructure, such as water gauge.

  5. Determining Selection across Heterogeneous Landscapes: A Perturbation-Based Method and Its Application to Modeling Evolution in Space.

    PubMed

    Wickman, Jonas; Diehl, Sebastian; Blasius, Bernd; Klausmeier, Christopher A; Ryabov, Alexey B; Brännström, Åke

    2017-04-01

    Spatial structure can decisively influence the way evolutionary processes unfold. To date, several methods have been used to study evolution in spatial systems, including population genetics, quantitative genetics, moment-closure approximations, and individual-based models. Here we extend the study of spatial evolutionary dynamics to eco-evolutionary models based on reaction-diffusion equations and adaptive dynamics. Specifically, we derive expressions for the strength of directional and stabilizing/disruptive selection that apply both in continuous space and to metacommunities with symmetrical dispersal between patches. For directional selection on a quantitative trait, this yields a way to integrate local directional selection across space and determine whether the trait value will increase or decrease. The robustness of this prediction is validated against quantitative genetics. For stabilizing/disruptive selection, we show that spatial heterogeneity always contributes to disruptive selection and hence always promotes evolutionary branching. The expression for directional selection is numerically very efficient and hence lends itself to simulation studies of evolutionary community assembly. We illustrate the application and utility of the expressions for this purpose with two examples of the evolution of resource utilization. Finally, we outline the domain of applicability of reaction-diffusion equations as a modeling framework and discuss their limitations.

  6. Spatial Distribution of Bed Particles in Natural Boulder-Bed Streams

    NASA Astrophysics Data System (ADS)

    Clancy, K. F.; Prestegaard, K. L.

    2001-12-01

    The Wolman pebble count is used to obtain the size distribution of bed particles in natural streams. Statistics such as median particle size (D50) are used in resistance calculations. Additional information such as bed particle heterogeneity may also be obtained from the particle distribution, which is used to predict sediment transport rates (Hey, 1979), (Ferguson, Prestegaard, Ashworth, 1989). Boulder-bed streams have an extreme range of particles in the particle size distribution ranging from sand size particles to particles larger than 0.5-m. A study of a natural boulder-bed reach demonstrated that the spatial distribution of the particles is a significant factor in predicting sediment transport and stream bed and bank stability. Further experiments were performed to test the limits of the spatial distribution's effect on sediment transport. Three stream reaches 40-m in length were selected with similar hydrologic characteristics and spatial distributions but varying average size particles. We used a grid 0.5 by 0.5-m and measured four particles within each grid cell. Digital photographs of the streambed were taken in each grid cell. The photographs were examined using image analysis software to obtain particle size and position of the largest particles (D84) within the reach's particle distribution. Cross section, topography and stream depth were surveyed. Velocity and velocity profiles were measured and recorded. With these data and additional surveys of bankfull floods, we tested the significance of the spatial distributions as average particle size decreases. The spatial distribution of streambed particles may provide information about stream valley formation, bank stability, sediment transport, and the growth rate of riparian vegetation.

  7. Women match men when learning a spatial skill.

    PubMed

    Spence, Ian; Yu, Jingjie Jessica; Feng, Jing; Marshman, Jeff

    2009-07-01

    Meta-analytic studies have concluded that although training improves spatial cognition in both sexes, the male advantage generally persists. However, because some studies run counter to this pattern, a closer examination of the anomaly is warranted. The authors investigated the acquisition of a basic skill (spatial selective attention) using a matched-pair two-wave longitudinal design. Participants were screened with the use of an attentional visual field task, with the objective of selecting and matching 10 male-female pairs, over a wide range (30% to 57% correct). Subsequently, 20 participants 17-23 years of age (selected from 43 screened) were trained for 10 hr (distributed over several sessions) by playing a first-person shooter video game. This genre is known to be highly effective in enhancing spatial skills. All 20 participants improved, with matched members of the male-female pairs achieving very similar gains, independent of starting level. This is consistent with the hypothesis that the learning trajectory of women is not inferior to that of men when acquiring a basic spatial skill. Training methods that develop basic spatial skills may be essential to achieve gender parity in both basic and complex spatial tasks.

  8. [Spatial differentiation and impact factors of Yutian Oasis's soil surface salt based on GWR model].

    PubMed

    Yuan, Yu Yun; Wahap, Halik; Guan, Jing Yun; Lu, Long Hui; Zhang, Qin Qin

    2016-10-01

    In this paper, topsoil salinity data gathered from 24 sampling sites in the Yutian Oasis were used, nine different kinds of environmental variables closely related to soil salinity were selec-ted as influencing factors, then, the spatial distribution characteristics of topsoil salinity and spatial heterogeneity of influencing factors were analyzed by combining the spatial autocorrelation with traditional regression analysis and geographically weighted regression model. Results showed that the topsoil salinity in Yutian Oasis was not of random distribution but had strong spatial dependence, and the spatial autocorrelation index for topsoil salinity was 0.479. Groundwater salinity, groundwater depth, elevation and temperature were the main factors influencing topsoil salt accumulation in arid land oases and they were spatially heterogeneous. The nine selected environmental variables except soil pH had significant influences on topsoil salinity with spatial disparity. GWR model was superior to the OLS model on interpretation and estimation of spatial non-stationary data, also had a remarkable advantage in visualization of modeling parameters.

  9. Spatial variation in pollinator-mediated selection on phenology, floral display and spur length in the orchid Gymnadenia conopsea.

    PubMed

    Chapurlat, Elodie; Ågren, Jon; Sletvold, Nina

    2015-12-01

    Spatial variation in plant-pollinator interactions may cause variation in pollinator-mediated selection on floral traits, but to establish this link conclusively experimental studies are needed. We quantified pollinator-mediated selection on flowering phenology and morphology in four populations of the fragrant orchid Gymnadenia conopsea, and compared selection mediated by diurnal and nocturnal pollinators in two of the populations. Variation in pollinator-mediated selection explained most of the among-population variation in the strength of directional and correlational selection. Pollinators mediated correlational selection on pairs of display traits, and on one display trait and spur length, a trait affecting pollination efficiency. Only nocturnal pollinators selected for longer spurs, and mediated stronger selection on the number of flowers compared with diurnal pollinators in one population. The two types of pollinators caused correlational selection on different pairs of traits and selected for different combinations of spur length and number of flowers. The results demonstrate that spatial variation in interactions with pollinators may result in differences in directional and correlational selection on floral traits in a plant with a semi-generalized pollination system, and suggest that differences in the relative importance of diurnal and nocturnal pollinators can cause variation in selection. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

  10. Managed care and the diffusion of endoscopy in fee-for-service Medicare.

    PubMed

    Mobley, Lee Rivers; Subramanian, Sujha; Koschinsky, Julia; Frech, H E; Trantham, Laurel Clayton; Anselin, Luc

    2011-12-01

    To determine whether Medicare managed care penetration impacted the diffusion of endoscopy services (sigmoidoscopy, colonoscopy) among the fee-for-service (FFS) Medicare population during 2001-2006. We model utilization rates for colonoscopy or sigmoidoscopy as impacted by both market supply and demand factors. We use spatial regression to perform ecological analysis of county-area utilization rates over two time intervals (2001-2003, 2004-2006) following Medicare benefits expansion in 2001 to cover colonoscopy for persons of average risk. We examine each technology in separate cross-sectional regressions estimated over early and later periods to assess differential effects on diffusion over time. We discuss selection factors in managed care markets and how failure to control perfectly for market selection might impact our managed care spillover estimates. Areas with worse socioeconomic conditions have lower utilization rates, especially for colonoscopy. Holding constant statistically the socioeconomic factors, we find that managed care spillover effects onto FFS Medicare utilization rates are negative for colonoscopy and positive for sigmoidoscopy. The spatial lag estimates are conservative and interpreted as a lower bound on true effects. Our findings suggest that managed care presence fostered persistence of the older technology during a time when it was rapidly being replaced by the newer technology. © Health Research and Educational Trust.

  11. The timecourse of space- and object-based attentional prioritization with varying degrees of certainty

    PubMed Central

    Drummond, Leslie; Shomstein, Sarah

    2013-01-01

    The relative contributions of objects (i.e., object-based) and underlying spatial (i.e., space-based representations) to attentional prioritization and selection remain unclear. In most experimental circumstances, the two representations overlap thus their respective contributions cannot be evaluated. Here, a dynamic version of the two-rectangle paradigm allowed for a successful de-coupling of spatial and object representations. Space-based (cued spatial location), cued end of the object, and object-based (locations within the cued object) effects were sampled at several timepoints following the cue with high or low certainty as to target location. In the high uncertainty condition spatial benefits prevailed throughout most of the timecourse, as evidenced by facilitatory and inhibitory effects. Additionally, the cued end of the object, rather than a whole object, received the attentional benefit. When target location was predictable (low uncertainty manipulation), only probabilities guided selection (i.e., evidence by a benefit for the statistically biased location). These results suggest that with high spatial uncertainty, all available information present within the stimulus display is used for the purposes of attentional selection (e.g., spatial locations, cued end of the object) albeit to varying degrees and at different time points. However, as certainty increases, only spatial certainty guides selection (i.e., object ends and whole objects are filtered out). Taken together, these results further elucidate the contributing role of space- and object-representations to attentional guidance. PMID:24367302

  12. AMES Stereo Pipeline Derived DEM Accuracy Experiment Using LROC-NAC Stereopairs and Weighted Spatial Dependence Simulation for Lunar Site Selection

    NASA Astrophysics Data System (ADS)

    Laura, J. R.; Miller, D.; Paul, M. V.

    2012-03-01

    An accuracy assessment of AMES Stereo Pipeline derived DEMs for lunar site selection using weighted spatial dependence simulation and a call for outside AMES derived DEMs to facilitate a statistical precision analysis.

  13. Spatial attention enhances the selective integration of activity from area MT.

    PubMed

    Masse, Nicolas Y; Herrington, Todd M; Cook, Erik P

    2012-09-01

    Distinguishing which of the many proposed neural mechanisms of spatial attention actually underlies behavioral improvements in visually guided tasks has been difficult. One attractive hypothesis is that attention allows downstream neural circuits to selectively integrate responses from the most informative sensory neurons. This would allow behavioral performance to be based on the highest-quality signals available in visual cortex. We examined this hypothesis by asking how spatial attention affects both the stimulus sensitivity of middle temporal (MT) neurons and their corresponding correlation with behavior. Analyzing a data set pooled from two experiments involving four monkeys, we found that spatial attention did not appreciably affect either the stimulus sensitivity of the neurons or the correlation between their activity and behavior. However, for those sessions in which there was a robust behavioral effect of attention, focusing attention inside the neuron's receptive field significantly increased the correlation between these two metrics, an indication of selective integration. These results suggest that, similar to mechanisms proposed for the neural basis of perceptual learning, the behavioral benefits of focusing spatial attention are attributable to selective integration of neural activity from visual cortical areas by their downstream targets.

  14. Missing in space: an evaluation of imputation methods for missing data in spatial analysis of risk factors for type II diabetes.

    PubMed

    Baker, Jannah; White, Nicole; Mengersen, Kerrie

    2014-11-20

    Spatial analysis is increasingly important for identifying modifiable geographic risk factors for disease. However, spatial health data from surveys are often incomplete, ranging from missing data for only a few variables, to missing data for many variables. For spatial analyses of health outcomes, selection of an appropriate imputation method is critical in order to produce the most accurate inferences. We present a cross-validation approach to select between three imputation methods for health survey data with correlated lifestyle covariates, using as a case study, type II diabetes mellitus (DM II) risk across 71 Queensland Local Government Areas (LGAs). We compare the accuracy of mean imputation to imputation using multivariate normal and conditional autoregressive prior distributions. Choice of imputation method depends upon the application and is not necessarily the most complex method. Mean imputation was selected as the most accurate method in this application. Selecting an appropriate imputation method for health survey data, after accounting for spatial correlation and correlation between covariates, allows more complete analysis of geographic risk factors for disease with more confidence in the results to inform public policy decision-making.

  15. Effects of Spatial and Feature Attention on Disparity-Rendered Structure-From-Motion Stimuli in the Human Visual Cortex

    PubMed Central

    Ip, Ifan Betina; Bridge, Holly; Parker, Andrew J.

    2014-01-01

    An important advance in the study of visual attention has been the identification of a non-spatial component of attention that enhances the response to similar features or objects across the visual field. Here we test whether this non-spatial component can co-select individual features that are perceptually bound into a coherent object. We combined human psychophysics and functional magnetic resonance imaging (fMRI) to demonstrate the ability to co-select individual features from perceptually coherent objects. Our study used binocular disparity and visual motion to define disparity structure-from-motion (dSFM) stimuli. Although the spatial attention system induced strong modulations of the fMRI response in visual regions, the non-spatial system’s ability to co-select features of the dSFM stimulus was less pronounced and variable across subjects. Our results demonstrate that feature and global feature attention effects are variable across participants, suggesting that the feature attention system may be limited in its ability to automatically select features within the attended object. Careful comparison of the task design suggests that even minor differences in the perceptual task may be critical in revealing the presence of global feature attention. PMID:24936974

  16. Processing the presence, placement, and properties of a distractor in spatial language tasks.

    PubMed

    Carlson, Laura A; Hill, Patrick L

    2008-03-01

    A common way to describe the location of an object is to spatially relate it to a nearby object. For such descriptions, the object being described is referred to as the located object; the object to which it is spatially related is referred to as the reference object. Typically, however, there are many nearby objects (distractors), resulting in the need for selection. We report three experiments that examine the extent to which a distractor in the display is processed during the selection of a reference object. Using acceptability ratings and production measures, we show that the presence and the placement ofa distractor have a significant impact on the assessment of the spatial relation between the located and reference objects; there is also evidence that the properties of the distractor are processed, but only under limited conditions. One implication is that the dimension that is most relevant to reference object selection is its spatial relation to the located object, rather than its salience with respect to other objects in the display.

  17. Managing Spatial Selections With Contextual Snapshots

    PubMed Central

    Mindek, P; Gröller, M E; Bruckner, S

    2014-01-01

    Spatial selections are a ubiquitous concept in visualization. By localizing particular features, they can be analysed and compared in different views. However, the semantics of such selections often depend on specific parameter settings and it can be difficult to reconstruct them without additional information. In this paper, we present the concept of contextual snapshots as an effective means for managing spatial selections in visualized data. The selections are automatically associated with the context in which they have been created. Contextual snapshots can also be used as the basis for interactive integrated and linked views, which enable in-place investigation and comparison of multiple visual representations of data. Our approach is implemented as a flexible toolkit with well-defined interfaces for integration into existing systems. We demonstrate the power and generality of our techniques by applying them to several distinct scenarios such as the visualization of simulation data, the analysis of historical documents and the display of anatomical data. PMID:25821284

  18. CROSS-SCALE CORRELATIONS AND THE DESIGN AND ANALYSIS OF AVIAN HABITAT SELECTION STUDIES

    EPA Science Inventory

    It has long been suggested that birds select habitat hierarchically, progressing from coarser to finer spatial scales. This hypothesis, in conjunction with the realization that many organisms likely respond to environmental patterns at multiple spatial scales, has led to a large ...

  19. Gap junctions between interneurons are required for normal spatial coding in the hippocampus and short-term spatial memory

    PubMed Central

    Allen, Kevin; Fuchs, Elke C.; Jaschonek, Hannah; Bannerman, David M.; Monyer, Hannah

    2011-01-01

    Gap junctions containing connexin-36 (Cx36) electrically couple interneurons in many brain regions and synchronize their activity. We used Cx36 knockout mice (Cx36−/−) to study the importance of electrical coupling between interneurons for spatial coding in the hippocampus and for different forms of hippocampus-dependent spatial memory. Recordings in behaving mice revealed that the spatial selectivity of hippocampal pyramidal neurons was reduced and less stable in Cx36−/− mice. Altered network activity was reflected in slower theta oscillations in the mutants. Temporal coding, assessed by determining the presence and characteristics of theta phase precession, had different dynamics in Cx36−/− mice compared to controls. At the behavioral level, Cx36−/− mice displayed impaired short-term spatial memory but normal spatial reference memory. These results highlight the functional role of electrically coupled interneurons for spatial coding and cognition. Moreover, they suggest that the precise spatial selectivity of place cells is not essential for normal performance on spatial tasks assessing associative long-term memory. PMID:21525295

  20. River bathymetry estimation based on the floodplains topography.

    NASA Astrophysics Data System (ADS)

    Bureš, Luděk; Máca, Petr; Roub, Radek; Pech, Pavel; Hejduk, Tomáš; Novák, Pavel

    2017-04-01

    Topographic model including River bathymetry (bed topography) is required for hydrodynamic simulation, water quality modelling, flood inundation mapping, sediment transport, ecological and geomorphologic assessments. The most common way to create the river bathymetry is to use of the spatial interpolation of discrete points or cross sections data. The quality of the generated bathymetry is dependent on the quality of the measurements, on the used technology and on the size of input dataset. Extensive measurements are often time consuming and expensive. Other option for creating of the river bathymetry is to use the methods of mathematical modelling. In the presented contribution we created the river bathymetry model. Model is based on the analytical curves. The curves are bent into shape of the cross sections. For the best description of the river bathymetry we need to know the values of the model parameters. For finding these parameters we use of the global optimization methods. The global optimization schemes is based on heuristics inspired by the natural processes. We use new type of DE (differential evolution) for finding the solutions of inverse problems, related to the parameters of mathematical model of river bed surfaces. The presented analysis discuss the dependence of model parameters on the selected characteristics. Selected characteristics are: (1) Topographic characteristics (slope and curvature in the left and right floodplains) determined on the base of DTM 5G (digital terrain model). (2) Optimization scheme. (3) Type of used analytical curves. The novel approach is applied on the three parts of Vltava river in Czech Republic. Each part of the river is described on the base of the point field. The point fields was measured with ADCP probe River surveyor M9. This work was supported by the Technology Agency of the Czech Republic, programme Alpha (project TA04020042 - New technologies bathymetry of rivers and reservoirs to determine their storage capacity and monitor the amount and dynamics of sediments) and Internal Grant Agency of Faculty of Environmental Sciences (CULS) (IGA/20164233). Keywords: bathymetry, global optimization, bed topography References: Merwade, Venkatesh. "Effect of spatial trends on interpolation of river bathymetry." Journal of Hydrology, 371.1, 169-181, 2009. Legleiter, Carl J., and Phaedon C. Kyriakidis. Spatial prediction of river channel topography by kriging. Earth Surface Processes and Landforms, 33.6 , 841-867, 2008. P. Maca and P. Pech and and J. Pavlasek. Comparing the Selected Transfer Functions and Local Optimization Methods for Neural Network Flood Runoff Forecast. Mathematical Problems in Engineering, vol. 2014, Article ID 782351, 10 pages, 2014. M. Jakubcova and P. Maca and and P. Pech. A Comparison of Selected Modifications of the Particle Swarm Optimization Algorithm. Journal of Applied Mathematics, vol. 2014, Article ID 293087, 10 pages, 2014.

  1. Evaluation of focused multipolar stimulation for cochlear implants in acutely deafened cats

    NASA Astrophysics Data System (ADS)

    George, Shefin S.; Wise, Andrew K.; Shivdasani, Mohit N.; Shepherd, Robert K.; Fallon, James B.

    2014-12-01

    Objective. The conductive nature of the fluids and tissues of the cochlea can lead to broad activation of spiral ganglion neurons using contemporary cochlear implant stimulation configurations such as monopolar (MP) stimulation. The relatively poor spatial selectivity is thought to limit implant performance, particularly in noisy environments. Several current focusing techniques have been proposed to reduce the spread of activation with the aim towards achieving improved clinical performance. Approach. The present research evaluated the efficacy of focused multipolar (FMP) stimulation, a relatively new focusing technique in the cochlea, and compared its efficacy to both MP stimulation and tripolar (TP) stimulation. The spread of neural activity across the inferior colliculus (IC), measured by recording the spatial tuning curve, was used as a measure of spatial selectivity. Adult cats (n = 6) were acutely deafened and implanted with an intracochlear electrode array before multi-unit responses were recorded across the cochleotopic gradient of the contralateral IC. Recordings were made in response to acoustic and electrical stimulation using the MP, TP and FMP configurations. Main results. FMP and TP stimulation resulted in greater spatial selectivity than MP stimulation. However, thresholds were significantly higher (p < 0.001) for FMP and TP stimulation compared to MP stimulation. There were no differences found in spatial selectivity and threshold between FMP and TP stimulation. Significance. The greater spatial selectivity of FMP and TP stimulation would be expected to result in improved clinical performance. However, further research will be required to demonstrate the efficacy of these modes of stimulation after longer durations of deafness.

  2. The coalescent process in models with selection and recombination.

    PubMed

    Hudson, R R; Kaplan, N L

    1988-11-01

    The statistical properties of the process describing the genealogical history of a random sample of genes at a selectively neutral locus which is linked to a locus at which natural selection operates are investigated. It is found that the equations describing this process are simple modifications of the equations describing the process assuming that the two loci are completely linked. Thus, the statistical properties of the genealogical process for a random sample at a neutral locus linked to a locus with selection follow from the results obtained for the selected locus. Sequence data from the alcohol dehydrogenase (Adh) region of Drosophila melanogaster are examined and compared to predictions based on the theory. It is found that the spatial distribution of nucleotide differences between Fast and Slow alleles of Adh is very similar to the spatial distribution predicted if balancing selection operates to maintain the allozyme variation at the Adh locus. The spatial distribution of nucleotide differences between different Slow alleles of Adh do not match the predictions of this simple model very well.

  3. Energy-selective Neutron Imaging for Three-dimensional Non-destructive Probing of Crystalline Structures

    NASA Astrophysics Data System (ADS)

    Peetermans, S.; Bopp, M.; Vontobel, P.; Lehmann, E. H.

    Common neutron imaging uses the full polychromatic neutron beam spectrum to reveal the material distribution in a non-destructive way. Performing it with a reduced energy band, i.e. energy-selective neutron imaging, allows access to local variation in sample crystallographic properties. Two sample categories can be discerned with different energy responses. Polycrystalline materials have an energy-dependent cross-section featuring Bragg edges. Energy-selective neutron imaging can be used to distinguish be- tween crystallographic phases, increase material sensitivity or penetration, improve quantification etc. An example of the latter is shown by the examination of copper discs prior to machining them into linear accelerator cavity structures. The cross-section of single crystals features distinct Bragg peaks. Based on their pattern, one can determine the orientation of the crystal, as in a Laue pattern, but with the tremendous advantage that the operation can be performed for each pixel, yielding crystal orientation maps at high spatial resolution. A wholly different method to investigate such samples is also introduced: neutron diffraction imaging. It is based on projections formed by neutrons diffracted from the crystal lattice out of the direct beam. The position of these projections on the detector gives information on the crystal orientation. The projection itself can be used to reconstruct the crystal shape. A three-dimensional mapping of local Bragg reflectivity or a grain orientation mapping can thus be obtained.

  4. Spatial and temporal dynamics of forest canopy gaps following selective logging in the eastern Amazon.

    Treesearch

    GREGORY P. ASNER; MICHAEL KELLER; JOSEN M. SILVA

    2004-01-01

    Selective logging is a dominant form of land use in the Amazon basin and throughout the humid tropics, yet little is known about the spatial variability of forest canopy gap formation and closure following timber harvests. We established chronosequences of large-area (14–158 ha) selective logging sites spanning a 3.5-year period of forest regeneration and two distinct...

  5. Exploratory study on Marine SDI implementation in Malaysia

    NASA Astrophysics Data System (ADS)

    Tarmidi, Zakri; Mohd Shariff, Abdul Rashid; Rodzi Mahmud, Ahmad; Zaiton Ibrahim, Zelina; Halim Hamzah, Abdul

    2016-06-01

    This paper discusses the explanatory study of the implementation of spatial data sharing between Malaysia's marine organisations. The survey method was selected with questionnaire as an instrument for data collection and analysis. The aim of the questionnaire was to determine the critical factors in enabling marine spatial data sharing in Malaysia, and the relationship between these indicators. A questionnaire was sent to 48 marine and coastal organisations in Malaysia, with 84.4% of respondents answering the questionnaire. The respondents selected were people who involved directly with GIS application in the organisations. The results show there are three main issues in implementing spatial data sharing; (1) GIS planning and implementation in the organisation, (2) spatial data sharing knowledge and implementation in the organisation and (3) collaboration to enable spatial data sharing within and between organisations. To improve GIS implementation, spatial data sharing implementation and collaboration in enabling spatial data sharing, a conceptual collaboration model was proposed with components of marine GIS strategic planning, spatial data sharing strategies and collaboration strategy.

  6. Nonlinear Y-Like Receptive Fields in the Early Visual Cortex: An Intermediate Stage for Building Cue-Invariant Receptive Fields from Subcortical Y Cells.

    PubMed

    Gharat, Amol; Baker, Curtis L

    2017-01-25

    Many of the neurons in early visual cortex are selective for the orientation of boundaries defined by first-order cues (luminance) as well as second-order cues (contrast, texture). The neural circuit mechanism underlying this selectivity is still unclear, but some studies have proposed that it emerges from spatial nonlinearities of subcortical Y cells. To understand how inputs from the Y-cell pathway might be pooled to generate cue-invariant receptive fields, we recorded visual responses from single neurons in cat Area 18 using linear multielectrode arrays. We measured responses to drifting and contrast-reversing luminance gratings as well as contrast modulation gratings. We found that a large fraction of these neurons have nonoriented responses to gratings, similar to those of subcortical Y cells: they respond at the second harmonic (F2) to high-spatial frequency contrast-reversing gratings and at the first harmonic (F1) to low-spatial frequency drifting gratings ("Y-cell signature"). For a given neuron, spatial frequency tuning for linear (F1) and nonlinear (F2) responses is quite distinct, similar to orientation-selective cue-invariant neurons. Also, these neurons respond to contrast modulation gratings with selectivity for the carrier (texture) spatial frequency and, in some cases, orientation. Their receptive field properties suggest that they could serve as building blocks for orientation-selective cue-invariant neurons. We propose a circuit model that combines ON- and OFF-center cortical Y-like cells in an unbalanced push-pull manner to generate orientation-selective, cue-invariant receptive fields. A significant fraction of neurons in early visual cortex have specialized receptive fields that allow them to selectively respond to the orientation of boundaries that are invariant to the cue (luminance, contrast, texture, motion) that defines them. However, the neural mechanism to construct such versatile receptive fields remains unclear. Using multielectrode recording, we found a large fraction of neurons in early visual cortex with receptive fields not selective for orientation that have spatial nonlinearities like those of subcortical Y cells. These are strong candidates for building cue-invariant orientation-selective neurons; we present a neural circuit model that pools such neurons in an imbalanced "push-pull" manner, to generate orientation-selective cue-invariant receptive fields. Copyright © 2017 the authors 0270-6474/17/370998-16$15.00/0.

  7. ERP correlates of anticipatory attention: spatial and non-spatial specificity and relation to subsequent selective attention.

    PubMed

    Dale, Corby L; Simpson, Gregory V; Foxe, John J; Luks, Tracy L; Worden, Michael S

    2008-06-01

    Brain-based models of visual attention hypothesize that attention-related benefits afforded to imperative stimuli occur via enhancement of neural activity associated with relevant spatial and non-spatial features. When relevant information is available in advance of a stimulus, anticipatory deployment processes are likely to facilitate allocation of attention to stimulus properties prior to its arrival. The current study recorded EEG from humans during a centrally-cued covert attention task. Cues indicated relevance of left or right visual field locations for an upcoming motion or orientation discrimination. During a 1 s delay between cue and S2, multiple attention-related events occurred at frontal, parietal and occipital electrode sites. Differences in anticipatory activity associated with the non-spatial task properties were found late in the delay, while spatially-specific modulation of activity occurred during both early and late periods and continued during S2 processing. The magnitude of anticipatory activity preceding the S2 at frontal scalp sites (and not occipital) was predictive of the magnitude of subsequent selective attention effects on the S2 event-related potentials observed at occipital electrodes. Results support the existence of multiple anticipatory attention-related processes, some with differing specificity for spatial and non-spatial task properties, and the hypothesis that levels of activity in anterior areas are important for effective control of subsequent S2 selective attention.

  8. Decoding and Reconstructing the Focus of Spatial Attention from the Topography of Alpha-band Oscillations.

    PubMed

    Samaha, Jason; Sprague, Thomas C; Postle, Bradley R

    2016-08-01

    Many aspects of perception and cognition are supported by activity in neural populations that are tuned to different stimulus features (e.g., orientation, spatial location, color). Goal-directed behavior, such as sustained attention, requires a mechanism for the selective prioritization of contextually appropriate representations. A candidate mechanism of sustained spatial attention is neural activity in the alpha band (8-13 Hz), whose power in the human EEG covaries with the focus of covert attention. Here, we applied an inverted encoding model to assess whether spatially selective neural responses could be recovered from the topography of alpha-band oscillations during spatial attention. Participants were cued to covertly attend to one of six spatial locations arranged concentrically around fixation while EEG was recorded. A linear classifier applied to EEG data during sustained attention demonstrated successful classification of the attended location from the topography of alpha power, although not from other frequency bands. We next sought to reconstruct the focus of spatial attention over time by applying inverted encoding models to the topography of alpha power and phase. Alpha power, but not phase, allowed for robust reconstructions of the specific attended location beginning around 450 msec postcue, an onset earlier than previous reports. These results demonstrate that posterior alpha-band oscillations can be used to track activity in feature-selective neural populations with high temporal precision during the deployment of covert spatial attention.

  9. Space-ecology set covering problem for modeling Daiyun Mountain Reserve, China

    NASA Astrophysics Data System (ADS)

    Lin, Chih-Wei; Liu, Jinfu; Huang, Jiahang; Zhang, Huiguang; Lan, Siren; Hong, Wei; Li, Wenzhou

    2018-02-01

    Site selection is an important issue in designing the nature reserve that has been studied over the years. However, a well-balanced relationship between preservation of biodiversity and site selection is still challenging. Unlike the existing methods, we consider three critical components, the spatial continuity, spatial compactness and ecological information to address the problem of designing the reserve. In this paper, we propose a new mathematical model of set covering problem called Space-ecology Set Covering Problem (SeSCP) for designing a reserve network. First, we generate the ecological information by forest resource investigation. Then, we split the landscape into elementary cells and calculate the ecological score of each cell. Next, we associate the ecological information with the spatial properties to select a set of cells to form a nature reserve for improving the ability of protecting the biodiversity. Two spatial constraints, continuity and compactability, are given in SeSCP. The continuity is to ensure that any selected site has to be connected with adjacent sites and the compactability is to minimize the perimeter of the selected sites. In computational experiments, we take Daiyun Mountain as a study area to demonstrate the feasibility and effectiveness of the proposed model.

  10. The role of spatial selective attention in working memory for locations: evidence from event-related potentials.

    PubMed

    Awh, E; Anllo-Vento, L; Hillyard, S A

    2000-09-01

    We investigated the hypothesis that the covert focusing of spatial attention mediates the on-line maintenance of location information in spatial working memory. During the delay period of a spatial working-memory task, behaviorally irrelevant probe stimuli were flashed at both memorized and nonmemorized locations. Multichannel recordings of event-related potentials (ERPs) were used to assess visual processing of the probes at the different locations. Consistent with the hypothesis of attention-based rehearsal, early ERP components were enlarged in response to probes that appeared at memorized locations. These visual modulations were similar in latency and topography to those observed after explicit manipulations of spatial selective attention in a parallel experimental condition that employed an identical stimulus display.

  11. Matrix Sublimation/Recrystallization for Imaging Proteins by Mass Spectrometry at High Spatial Resolution

    PubMed Central

    Yang, Junhai; Caprioli, Richard M.

    2011-01-01

    We have employed matrix deposition by sublimation for protein image analysis on tissue sections using a hydration/recrystallization process that produces high quality MALDI mass spectra and high spatial resolution ion images. We systematically investigated different washing protocols, the effect of tissue section thickness, the amount of sublimated matrix per unit area and different recrystallization conditions. The results show that an organic solvent rinse followed by ethanol/water rinses substantially increased sensitivity for the detection of proteins. Both the thickness of tissue section and amount of sinapinic acid sublimated per unit area have optimal ranges for maximal protein signal intensity. Ion images of mouse and rat brain sections at 50, 20 and 10 µm spatial resolution are presented and are correlated with H&E stained optical images. For targeted analysis, histology directed imaging can be performed using this protocol where MS analysis and H&E staining are performed on the same section. PMID:21639088

  12. Color selectivity of the spatial congruency effect: evidence from the focused attention paradigm.

    PubMed

    Makovac, Elena; Gerbino, Walter

    2014-01-01

    The multisensory response enhancement (MRE), occurring when the response to a visual target integrated with a spatially congruent sound is stronger than the response to the visual target alone, is believed to be mediated by the superior colliculus (SC) (Stein & Meredith, 1993). Here, we used a focused attention paradigm to show that the spatial congruency effect occurs with red (SC-effective) but not blue (SC-ineffective) visual stimuli, when presented with spatially congruent sounds. To isolate the chromatic component of SC-ineffective targets and to demonstrate the selectivity of the spatial congruency effect we used the random luminance modulation technique (Experiment 1) and the tritanopic technique (Experiment 2). Our results indicate that the spatial congruency effect does not require the distribution of attention over different sensory modalities and provide correlational evidence that the SC mediates the effect.

  13. Time takes space: selective effects of multitasking on concurrent spatial processing.

    PubMed

    Mäntylä, Timo; Coni, Valentina; Kubik, Veit; Todorov, Ivo; Del Missier, Fabio

    2017-08-01

    Many everyday activities require coordination and monitoring of complex relations of future goals and deadlines. Cognitive offloading may provide an efficient strategy for reducing control demands by representing future goals and deadlines as a pattern of spatial relations. We tested the hypothesis that multiple-task monitoring involves time-to-space transformational processes, and that these spatial effects are selective with greater demands on coordinate (metric) than categorical (nonmetric) spatial relation processing. Participants completed a multitasking session in which they monitored four series of deadlines, running on different time scales, while making concurrent coordinate or categorical spatial judgments. We expected and found that multitasking taxes concurrent coordinate, but not categorical, spatial processing. Furthermore, males showed a better multitasking performance than females. These findings provide novel experimental evidence for the hypothesis that efficient multitasking involves metric relational processing.

  14. Enhancing the visuo-spatial aptitude of students

    NASA Astrophysics Data System (ADS)

    Lord, Thomas R.

    Research to date has not been able to agree whether visuo-spatial ability can be influenced through practice. Many have concluded that spatial awareness is an innate phenomena and cannot be learned. Others contend that an individual's visuo-spatial potentials are acquired through interactions with the environment. Many of these theorists believe that spatial thinking can be developed through interactive exercises devised to encourage mental image formation and manipulation. To help alleviate the confusion surrounding this question the following study was undertaken. Eighty-four college undergraduates were randomly placed into control and experimental sections. Student records were examined to assure that the groups did not differ significantly in their verbal or math proficiency and pertinent pretests were given to ascertain spatial levels. The groups were also similar on their male and female ratios. During the semester the experimental section was treated to a 30-minute interaction each week. These sessions involved spatial exercises that required the participants to mentally bisect three-dimensional geometric figures and to envision the shape of the two-dimensional surface formed by the bisection. The subjects drew their mental image of this surface on a sheet of paper. Fourteen weeks later both groups were post tested with a second comparable version of the pretest. Statistical t tests were performed on the group means to see if significant differences developed between the sections. The results indicate that statistical improvement in visuo-spatial cognition did occur for the experimental group in spatial visualization, and spatial orientation. This finding suggests that the weekly intervention sessions had a positive effect on the students' visuo-spatial awareness. These results, therefore, tend to support those researchers that claim visuo-spatial aptitude can be enhanced through teaching.

  15. Cultural-based particle swarm for dynamic optimisation problems

    NASA Astrophysics Data System (ADS)

    Daneshyari, Moayed; Yen, Gary G.

    2012-07-01

    Many practical optimisation problems are with the existence of uncertainties, among which a significant number belong to the dynamic optimisation problem (DOP) category in which the fitness function changes through time. In this study, we propose the cultural-based particle swarm optimisation (PSO) to solve DOP problems. A cultural framework is adopted incorporating the required information from the PSO into five sections of the belief space, namely situational, temporal, domain, normative and spatial knowledge. The stored information will be adopted to detect the changes in the environment and assists response to the change through a diversity-based repulsion among particles and migration among swarms in the population space, and also helps in selecting the leading particles in three different levels, personal, swarm and global levels. Comparison of the proposed heuristics over several difficult dynamic benchmark problems demonstrates the better or equal performance with respect to most of other selected state-of-the-art dynamic PSO heuristics.

  16. Texture analysis of Napoleonic War Era copper bolts

    NASA Astrophysics Data System (ADS)

    Malamud, Florencia; Northover, Shirley; James, Jon; Northover, Peter; Kelleher, Joe

    2016-04-01

    Neutron diffraction techniques are suitable for volume texture analyses due to high penetration of thermal neutrons in most materials. We have implemented a new data analysis methodology that employed the spatial resolution achievable by a time-of-flight neutron strain scanner to non-destructively determine the crystallographic texture at selected locations within a macroscopic sample. The method is based on defining the orientation distribution function of the crystallites from several incomplete pole figures, and it has been implemented on ENGIN-X, a neutron strain scanner at the Isis Facility in the UK. Here, we demonstrate the application of this new texture analysis methodology in determining the crystallographic texture at selected locations within museum quality archaeological objects up to 1 m in length. The results were verified using samples of similar, but less valuable, objects by comparing the results of applying this method with those obtained using both electron backscatter diffraction and X-ray diffraction on their cross sections.

  17. A new type of change blindness: smooth, isoluminant color changes are monitored on a coarse spatial scale.

    PubMed

    Goddard, Erin; Clifford, Colin W G

    2013-04-22

    Attending selectively to changes in our visual environment may help filter less important, unchanging information within a scene. Here, we demonstrate that color changes can go unnoticed even when they occur throughout an otherwise static image. The novelty of this demonstration is that it does not rely upon masking by a visual disruption or stimulus motion, nor does it require the change to be very gradual and restricted to a small section of the image. Using a two-interval, forced-choice change-detection task and an odd-one-out localization task, we showed that subjects were slowest to respond and least accurate (implying that change was hardest to detect) when the color changes were isoluminant, smoothly varying, and asynchronous with one another. This profound change blindness offers new constraints for theories of visual change detection, implying that, in the absence of transient signals, changes in color are typically monitored at a coarse spatial scale.

  18. 3-D inelastic analysis methods for hot section components (base program). [turbine blades, turbine vanes, and combustor liners

    NASA Technical Reports Server (NTRS)

    Wilson, R. B.; Bak, M. J.; Nakazawa, S.; Banerjee, P. K.

    1984-01-01

    A 3-D inelastic analysis methods program consists of a series of computer codes embodying a progression of mathematical models (mechanics of materials, special finite element, boundary element) for streamlined analysis of combustor liners, turbine blades, and turbine vanes. These models address the effects of high temperatures and thermal/mechanical loadings on the local (stress/strain) and global (dynamics, buckling) structural behavior of the three selected components. These models are used to solve 3-D inelastic problems using linear approximations in the sense that stresses/strains and temperatures in generic modeling regions are linear functions of the spatial coordinates, and solution increments for load, temperature and/or time are extrapolated linearly from previous information. Three linear formulation computer codes, referred to as MOMM (Mechanics of Materials Model), MHOST (MARC-Hot Section Technology), and BEST (Boundary Element Stress Technology), were developed and are described.

  19. Time-varying spatial data integration and visualization: 4 Dimensions Environmental Observations Platform (4-DEOS)

    NASA Astrophysics Data System (ADS)

    Paciello, Rossana; Coviello, Irina; Filizzola, Carolina; Genzano, Nicola; Lisi, Mariano; Mazzeo, Giuseppe; Pergola, Nicola; Sileo, Giancanio; Tramutoli, Valerio

    2014-05-01

    In environmental studies the integration of heterogeneous and time-varying data, is a very common requirement for investigating and possibly visualize correlations among physical parameters underlying the dynamics of complex phenomena. Datasets used in such kind of applications has often different spatial and temporal resolutions. In some case superimposition of asynchronous layers is required. Traditionally the platforms used to perform spatio-temporal visual data analyses allow to overlay spatial data, managing the time using 'snapshot' data model, each stack of layers being labeled with different time. But this kind of architecture does not incorporate the temporal indexing neither the third spatial dimension which is usually given as an independent additional layer. Conversely, the full representation of a generic environmental parameter P(x,y,z,t) in the 4D space-time domain could allow to handle asynchronous datasets as well as less traditional data-products (e.g. vertical sections, punctual time-series, etc.) . In this paper we present the 4 Dimensions Environmental Observation Platform (4-DEOS), a system based on a web services architecture Client-Broker-Server. This platform is a new open source solution for both a timely access and an easy integration and visualization of heterogeneous (maps, vertical profiles or sections, punctual time series, etc.) asynchronous, geospatial products. The innovative aspect of the 4-DEOS system is that users can analyze data/products individually moving through time, having also the possibility to stop the display of some data/products and focus on other parameters for better studying their temporal evolution. This platform gives the opportunity to choose between two distinct display modes for time interval or for single instant. Users can choose to visualize data/products in two ways: i) showing each parameter in a dedicated window or ii) visualize all parameters overlapped in a single window. A sliding time bar, allows to follow the temporal evolution of the selected data/product. With this software, users have the possibility to identify events partially correlated each other not only in the spatial dimension but also in the time domain even at different time lags.

  20. Spatial Mutual Information Based Hyperspectral Band Selection for Classification

    PubMed Central

    2015-01-01

    The amount of information involved in hyperspectral imaging is large. Hyperspectral band selection is a popular method for reducing dimensionality. Several information based measures such as mutual information have been proposed to reduce information redundancy among spectral bands. Unfortunately, mutual information does not take into account the spatial dependency between adjacent pixels in images thus reducing its robustness as a similarity measure. In this paper, we propose a new band selection method based on spatial mutual information. As validation criteria, a supervised classification method using support vector machine (SVM) is used. Experimental results of the classification of hyperspectral datasets show that the proposed method can achieve more accurate results. PMID:25918742

  1. The evolution of intermediate castration virulence and ant coexistence in a spatially structured environment.

    PubMed

    Szilágyi, András; Scheuring, István; Edwards, David P; Orivel, Jerome; Yu, Douglas W

    2009-12-01

    Theory suggests that spatial structuring should select for intermediate levels of virulence in parasites, but empirical tests are rare and have never been conducted with castration (sterilizing) parasites. To test this theory in a natural landscape, we construct a spatially explicit model of the symbiosis between the ant-plant Cordia nodosa and its two, protecting ant symbionts, Allomerus and Azteca. Allomerus is also a castration parasite, preventing fruiting to increase colony fecundity. Limiting the dispersal of Allomerus and host plant selects for intermediate castration virulence. Increasing the frequency of the mutualist, Azteca, selects for higher castration virulence in Allomerus, because seeds from Azteca-inhabited plants are a public good that Allomerus exploits. These results are consistent with field observations and, to our knowledge, provide the first empirical evidence supporting the hypothesis that spatial structure can reduce castration virulence and the first such evidence in a natural landscape for either mortality or castration virulence.

  2. Paying attention to working memory: Similarities in the spatial distribution of attention in mental and physical space.

    PubMed

    Sahan, Muhammet Ikbal; Verguts, Tom; Boehler, Carsten Nicolas; Pourtois, Gilles; Fias, Wim

    2016-08-01

    Selective attention is not limited to information that is physically present in the external world, but can also operate on mental representations in the internal world. However, it is not known whether the mechanisms of attentional selection operate in similar fashions in physical and mental space. We studied the spatial distributions of attention for items in physical and mental space by comparing how successfully distractors were rejected at varying distances from the attended location. The results indicated very similar distribution characteristics of spatial attention in physical and mental space. Specifically, we found that performance monotonically improved with increasing distractor distance relative to the attended location, suggesting that distractor confusability is particularly pronounced for nearby distractors, relative to distractors farther away. The present findings suggest that mental representations preserve their spatial configuration in working memory, and that similar mechanistic principles underlie selective attention in physical and in mental space.

  3. Spatializing Critical Education: Progress and Cautions

    ERIC Educational Resources Information Center

    Ferrare, Joseph J.; Apple, Michael W.

    2010-01-01

    Recently critical scholars have shown a renewed interest in spatial relations in educational contexts. In this essay we use selections from Gulson and Symes's edited volume "Spatial theories of education" as a point of departure to examine what spatial analysis can contribute to the critical education traditions. We argue that, when done…

  4. Strategy Training Eliminates Sex Differences in Spatial Problem Solving in a STEM Domain

    ERIC Educational Resources Information Center

    Stieff, Mike; Dixon, Bonnie L.; Ryu, Minjung; Kumi, Bryna C.; Hegarty, Mary

    2014-01-01

    Poor spatial ability can limit success in science, technology, engineering, and mathematics (STEM) disciplines. Many initiatives aim to increase STEM achievement and degree attainment through selective recruitment of high-spatial students or targeted training to improve spatial ability. The current study examines an alternative approach to…

  5. A New Integrated Threshold Selection Methodology for Spatial Forecast Verification of Extreme Events

    NASA Astrophysics Data System (ADS)

    Kholodovsky, V.

    2017-12-01

    Extreme weather and climate events such as heavy precipitation, heat waves and strong winds can cause extensive damage to the society in terms of human lives and financial losses. As climate changes, it is important to understand how extreme weather events may change as a result. Climate and statistical models are often independently used to model those phenomena. To better assess performance of the climate models, a variety of spatial forecast verification methods have been developed. However, spatial verification metrics that are widely used in comparing mean states, in most cases, do not have an adequate theoretical justification to benchmark extreme weather events. We proposed a new integrated threshold selection methodology for spatial forecast verification of extreme events that couples existing pattern recognition indices with high threshold choices. This integrated approach has three main steps: 1) dimension reduction; 2) geometric domain mapping; and 3) thresholds clustering. We apply this approach to an observed precipitation dataset over CONUS. The results are evaluated by displaying threshold distribution seasonally, monthly and annually. The method offers user the flexibility of selecting a high threshold that is linked to desired geometrical properties. The proposed high threshold methodology could either complement existing spatial verification methods, where threshold selection is arbitrary, or be directly applicable in extreme value theory.

  6. Language supports young children’s use of spatial relations to remember locations

    PubMed Central

    Miller, Hilary E.; Patterson, Rebecca; Simmering, Vanessa R.

    2016-01-01

    Two experiments investigated the role of language in children’s spatial recall performance. In particular, we assessed whether selecting an intrinsic reference frame could be improved through verbal encoding. Selecting an intrinsic reference frame requires remembering locations relative to nearby objects independent of one’s body (egocentric) or distal environmental (allocentric) cues, and does not reliably occur in children under 5 years of age (Nardini, Burgess, Breckenridge, & Atkinson, 2006). The current studies tested the relation between spatial language and 4-year-olds’ selection of an intrinsic reference frame in spatial recall. Experiment 1 showed that providing 4-year-olds with location-descriptive cues during (Exp. 1a) or before (Exp. 1b) the recall task improved performance both overall and specifically on trials relying most on an intrinsic reference frame. Additionally, children’s recall performance was predicted by their verbal descriptions of the task space (Exp. 1a control condition). Non-verbally highlighting relations among objects during the recall task (Exp. 2) supported children’s performance relative to the control condition, but significantly less than the location-descriptive cues. These results suggest that the ability to verbally represent relations is a potential mechanism that could account for developmental changes in the selection of an intrinsic reference frame during spatial recall. PMID:26896902

  7. Language supports young children's use of spatial relations to remember locations.

    PubMed

    Miller, Hilary E; Patterson, Rebecca; Simmering, Vanessa R

    2016-05-01

    Two experiments investigated the role of language in children's spatial recall performance. In particular, we assessed whether selecting an intrinsic reference frame could be improved through verbal encoding. Selecting an intrinsic reference frame requires remembering locations relative to nearby objects independent of one's body (egocentric) or distal environmental (allocentric) cues, and does not reliably occur in children under 5 years of age (Nardini, Burgess, Breckenridge, & Atkinson, 2006). The current studies tested the relation between spatial language and 4-year-olds' selection of an intrinsic reference frame in spatial recall. Experiment 1 showed that providing 4-year-olds with location-descriptive cues during (Exp. 1a) or before (Exp. 1b) the recall task improved performance both overall and specifically on trials relying most on an intrinsic reference frame. Additionally, children's recall performance was predicted by their verbal descriptions of the task space (Exp. 1a control condition). Non-verbally highlighting relations among objects during the recall task (Exp. 2) supported children's performance relative to the control condition, but significantly less than the location-descriptive cues. These results suggest that the ability to verbally represent relations is a potential mechanism that could account for developmental changes in the selection of an intrinsic reference frame during spatial recall. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Spatial enhancement of ECG using diagnostic similarity score based lead selective multi-scale linear model.

    PubMed

    Nallikuzhy, Jiss J; Dandapat, S

    2017-06-01

    In this work, a new patient-specific approach to enhance the spatial resolution of ECG is proposed and evaluated. The proposed model transforms a three-lead ECG into a standard twelve-lead ECG thereby enhancing its spatial resolution. The three leads used for prediction are obtained from the standard twelve-lead ECG. The proposed model takes advantage of the improved inter-lead correlation in wavelet domain. Since the model is patient-specific, it also selects the optimal predictor leads for a given patient using a lead selection algorithm. The lead selection algorithm is based on a new diagnostic similarity score which computes the diagnostic closeness between the original and the spatially enhanced leads. Standard closeness measures are used to assess the performance of the model. The similarity in diagnostic information between the original and the spatially enhanced leads are evaluated using various diagnostic measures. Repeatability and diagnosability are performed to quantify the applicability of the model. A comparison of the proposed model is performed with existing models that transform a subset of standard twelve-lead ECG into the standard twelve-lead ECG. From the analysis of the results, it is evident that the proposed model preserves diagnostic information better compared to other models. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. The Relationship between Preschoolers' Selective Attention and Memory for Location Strategies

    ERIC Educational Resources Information Center

    Blumberg, F.C.; Torenberg, M.; Randall, J.D.

    2005-01-01

    Late and early preschoolers' attention and spatial strategies were examined in response to instructions to recall relevant objects [Blumberg, F. C. & Torenberg, M. (2003). The impact of spatial cues on preschoolers' selective attention. Journal of Genetic Psychology, 164, 42-53] and irrelevant objects [Blumberg, F. C. & Torenberg, M. (in press).…

  10. A CONCEPTUAL FRAMEWORK FOR SELECTING AND ANALYZING STRESSOR DATA TO STUDY SPECIES RICHNESS AT LARGE SPATIAL SCALES

    EPA Science Inventory

    In this paper we develop a conceptual framework for selecting stressor data and anlyzing their relationship to geographic patterns of species richness at large spatial scales. Aspects of climate and topography, which are not stressors per se, have been most strongly linked with g...

  11. Scale dependency of American marten (Martes americana) habitat relations [Chapter 12

    Treesearch

    Andrew J. Shirk; Tzeidle N. Wasserman; Samuel A. Cushman; Martin G. Raphael

    2012-01-01

    Animals select habitat resources at multiple spatial scales; therefore, explicit attention to scale-dependency when modeling habitat relations is critical to understanding how organisms select habitat in complex landscapes. Models that evaluate habitat variables calculated at a single spatial scale (e.g., patch, home range) fail to account for the effects of...

  12. Den use and selection by northern flying squirrels in fragmented landscapes

    Treesearch

    Sanjay Pyare; Winston P. Smith; Colin S. Shanley

    2010-01-01

    We studied den use and den-habitat selection by the Prince of Wales Island flying squirrel (Glaucomys sabrinus griseifrons) at multiple spatial scales in fragmented temperate rain-forest habitats because of the role dens play in the distribution, reproduction, and population density of this endemic subspecies. We observed differences in spatial...

  13. A technique to calibrate spatial light modulator for varying phase response over its spatial regions

    NASA Astrophysics Data System (ADS)

    Gupta, Deepak K.; Tata, B. V. R.; Ravindran, T. R.

    2018-05-01

    Holographic Optical Tweezers (HOTs) employ the technique of beam shaping and holography in an optical manipulation system to create a multitude of focal spots for simultaneous trapping and manipulation of sub-microscopic particles. The beam shaping is accomplished by the use of a phase only liquid crystal spatial light modulator (SLM). The efficiency and the uniformity in the generated traps greatly depend on the phase response behavior of SLMs. In addition the SLMs are found to show different phase response over its different spatial regions, due to non-flat structure of SLMs. Also the phase responses are found to vary over different spatial regions due to non-uniform illumination (Gaussian profile of incident laser). There are various techniques to calibrate for the varying phase response by characterizing the phase modulation at various sub-sections. We present a simple and fast technique to calibrate the SLM suffering with spatially varying phase response. We divide the SLM into many sub-sections and optimize the brightness and gamma of each sub-section for maximum diffraction efficiency. This correction is incorporated in the Weighted Gerchberg Saxton (WGS) algorithm for generation of holograms.

  14. The Threshold Hypothesis Applied to Spatial Skill and Mathematics

    ERIC Educational Resources Information Center

    Freer, Daniel

    2017-01-01

    This cross-sectional study assessed the relation between spatial skills and mathematics in 854 participants across kindergarten, third grade, and sixth grade. Specifically, the study probed for a threshold for spatial skills when performing mathematics, above which spatial scores and mathematics scores would be significantly less related. This…

  15. Spatial accessibility to physical activity facilities and to food outlets and overweight in French youth

    PubMed Central

    Casey, R; Chaix, B; Weber, C; Schweitzer, B; Charreire, H; Salze, P; Badariotti, D; Banos, A; Oppert, J-M; Simon, C

    2012-01-01

    Objective: Some characteristics of the built environment have been associated with obesity in youth. Our aim was to determine whether individual and environmental socio-economic characteristics modulate the relation between youth overweight and spatial accessibility to physical activity (PA) facilities and to food outlets. Design: Cross-sectional study. Subjects: 3293 students, aged 12±0.6 years, randomly selected from eastern France middle schools. Measurements and methods: Using geographical information systems (GIS), spatial accessibility to PA facilities (urban and nature) was assessed using the distance to PA facilities at the municipality level; spatial accessibility to food outlets (general food outlets, bakeries and fast-food outlets) was calculated at individual level using the student home address and the food outlets addresses. Relations of weight status with spatial accessibility to PA facilities and to food outlets were analysed using mixed logistic models, testing potential direct and interaction effects of individual and environmental socio-economic characteristics. Results: Individual socio-economic status modulated the relation between spatial accessibility to PA facilities and to general food outlets and overweight. The likelihood of being overweight was higher when spatial accessibility to urban PA facilities and to general food outlets was low, but in children of blue-collar-workers only. The odds ratio (OR) (95% confidence interval) for being overweight of blue-collar-workers children compared with non-blue-collar-workers children was 1.76 (1.25–2.49) when spatial accessibility to urban PA facilities was low. This OR was 1.86 (1.20–2.86) when spatial accessibility to general food outlets was low. There was no significant relationship of overweight with either nature PA facilities or other food outlets (bakeries and fast-food outlets). Conclusion: These results indicate that disparities in spatial accessibility to PA facilities and to general food outlets may amplify the risk of overweight in socio-economically disadvantaged youth. These data should be relevant for influencing health policies and urban planning at both a national and local level. PMID:22310474

  16. An unsupervised MVA method to compare specific regions in human breast tumor tissue samples using ToF-SIMS.

    PubMed

    Bluestein, Blake M; Morrish, Fionnuala; Graham, Daniel J; Guenthoer, Jamie; Hockenbery, David; Porter, Peggy L; Gamble, Lara J

    2016-03-21

    Imaging time-of-flight secondary ion mass spectrometry (ToF-SIMS) and principal component analysis (PCA) were used to investigate two sets of pre- and post-chemotherapy human breast tumor tissue sections to characterize lipids associated with tumor metabolic flexibility and response to treatment. The micron spatial resolution imaging capability of ToF-SIMS provides a powerful approach to attain spatially-resolved molecular and cellular data from cancerous tissues not available with conventional imaging techniques. Three ca. 1 mm(2) areas per tissue section were analyzed by stitching together 200 μm × 200 μm raster area scans. A method to isolate and analyze specific tissue regions of interest by utilizing PCA of ToF-SIMS images is presented, which allowed separation of cellularized areas from stromal areas. These PCA-generated regions of interest were then used as masks to reconstruct representative spectra from specifically stromal or cellular regions. The advantage of this unsupervised selection method is a reduction in scatter in the spectral PCA results when compared to analyzing all tissue areas or analyzing areas highlighted by a pathologist. Utilizing this method, stromal and cellular regions of breast tissue biopsies taken pre- versus post-chemotherapy demonstrate chemical separation using negatively-charged ion species. In this sample set, the cellular regions were predominantly all cancer cells. Fatty acids (i.e. palmitic, oleic, and stearic), monoacylglycerols, diacylglycerols and vitamin E profiles were distinctively different between the pre- and post-therapy tissues. These results validate a new unsupervised method to isolate and interpret biochemically distinct regions in cancer tissues using imaging ToF-SIMS data. In addition, the method developed here can provide a framework to compare a variety of tissue samples using imaging ToF-SIMS, especially where there is section-to-section variability that makes it difficult to use a serial hematoxylin and eosin (H&E) stained section to direct the SIMS analysis.

  17. Auditory Attentional Control and Selection during Cocktail Party Listening

    PubMed Central

    Hill, Kevin T.

    2010-01-01

    In realistic auditory environments, people rely on both attentional control and attentional selection to extract intelligible signals from a cluttered background. We used functional magnetic resonance imaging to examine auditory attention to natural speech under such high processing-load conditions. Participants attended to a single talker in a group of 3, identified by the target talker's pitch or spatial location. A catch-trial design allowed us to distinguish activity due to top-down control of attention versus attentional selection of bottom-up information in both the spatial and spectral (pitch) feature domains. For attentional control, we found a left-dominant fronto-parietal network with a bias toward spatial processing in dorsal precentral sulcus and superior parietal lobule, and a bias toward pitch in inferior frontal gyrus. During selection of the talker, attention modulated activity in left intraparietal sulcus when using talker location and in bilateral but right-dominant superior temporal sulcus when using talker pitch. We argue that these networks represent the sources and targets of selective attention in rich auditory environments. PMID:19574393

  18. Neurophysiological Organization of the Middle Face Patch in Macaque Inferior Temporal Cortex

    PubMed Central

    Aparicio, Paul L.; Issa, Elias B.

    2016-01-01

    While early cortical visual areas contain fine scale spatial organization of neuronal properties, such as orientation preference, the spatial organization of higher-level visual areas is less well understood. The fMRI demonstration of face-preferring regions in human ventral cortex and monkey inferior temporal cortex (“face patches”) raises the question of how neural selectivity for faces is organized. Here, we targeted hundreds of spatially registered neural recordings to the largest fMRI-identified face-preferring region in monkeys, the middle face patch (MFP), and show that the MFP contains a graded enrichment of face-preferring neurons. At its center, as much as 93% of the sites we sampled responded twice as strongly to faces than to nonface objects. We estimate the maximum neurophysiological size of the MFP to be ∼6 mm in diameter, consistent with its previously reported size under fMRI. Importantly, face selectivity in the MFP varied strongly even between neighboring sites. Additionally, extremely face-selective sites were ∼40 times more likely to be present inside the MFP than outside. These results provide the first direct quantification of the size and neural composition of the MFP by showing that the cortical tissue localized to the fMRI defined region consists of a very high fraction of face-preferring sites near its center, and a monotonic decrease in that fraction along any radial spatial axis. SIGNIFICANCE STATEMENT The underlying organization of neurons that give rise to the large spatial regions of activity observed with fMRI is not well understood. Neurophysiological studies that have targeted the fMRI identified face patches in monkeys have provided evidence for both large-scale clustering and a heterogeneous spatial organization. Here we used a novel x-ray imaging system to spatially map the responses of hundreds of sites in and around the middle face patch. We observed that face-selective signal localized to the middle face patch was characterized by a gradual spatial enrichment. Furthermore, strongly face-selective sites were ∼40 times more likely to be found inside the patch than outside of the patch. PMID:27810930

  19. Neurophysiological Organization of the Middle Face Patch in Macaque Inferior Temporal Cortex.

    PubMed

    Aparicio, Paul L; Issa, Elias B; DiCarlo, James J

    2016-12-14

    While early cortical visual areas contain fine scale spatial organization of neuronal properties, such as orientation preference, the spatial organization of higher-level visual areas is less well understood. The fMRI demonstration of face-preferring regions in human ventral cortex and monkey inferior temporal cortex ("face patches") raises the question of how neural selectivity for faces is organized. Here, we targeted hundreds of spatially registered neural recordings to the largest fMRI-identified face-preferring region in monkeys, the middle face patch (MFP), and show that the MFP contains a graded enrichment of face-preferring neurons. At its center, as much as 93% of the sites we sampled responded twice as strongly to faces than to nonface objects. We estimate the maximum neurophysiological size of the MFP to be ∼6 mm in diameter, consistent with its previously reported size under fMRI. Importantly, face selectivity in the MFP varied strongly even between neighboring sites. Additionally, extremely face-selective sites were ∼40 times more likely to be present inside the MFP than outside. These results provide the first direct quantification of the size and neural composition of the MFP by showing that the cortical tissue localized to the fMRI defined region consists of a very high fraction of face-preferring sites near its center, and a monotonic decrease in that fraction along any radial spatial axis. The underlying organization of neurons that give rise to the large spatial regions of activity observed with fMRI is not well understood. Neurophysiological studies that have targeted the fMRI identified face patches in monkeys have provided evidence for both large-scale clustering and a heterogeneous spatial organization. Here we used a novel x-ray imaging system to spatially map the responses of hundreds of sites in and around the middle face patch. We observed that face-selective signal localized to the middle face patch was characterized by a gradual spatial enrichment. Furthermore, strongly face-selective sites were ∼40 times more likely to be found inside the patch than outside of the patch. Copyright © 2016 the authors 0270-6474/16/3612729-17$15.00/0.

  20. Spatial Integration under Contextual Control in a Virtual Environment

    ERIC Educational Resources Information Center

    Molet, Mikael; Gambet, Boris; Bugallo, Mehdi; Miller, Ralph R.

    2012-01-01

    The role of context was examined in the selection and integration of independently learned spatial relationships. Using a dynamic 3D virtual environment, participants learned one spatial relationship between landmarks A and B which was established in one virtual context (e.g., A is left of B) and a different spatial relationship which was…

  1. Individual Spatial Responses towards Roads: Implications for Mortality Risk

    PubMed Central

    Grilo, Clara; Sousa, Joana; Ascensão, Fernando; Matos, Hugo; Leitão, Inês; Pinheiro, Paula; Costa, Monica; Bernardo, João; Reto, Dyana; Lourenço, Rui; Santos-Reis, Margarida; Revilla, Eloy

    2012-01-01

    Background Understanding the ecological consequences of roads and developing ways to mitigate their negative effects has become an important goal for many conservation biologists. Most mitigation measures are based on road mortality and barrier effects data. However, studying fine-scale individual spatial responses in roaded landscapes may help develop more cohesive road planning strategies for wildlife conservation. Methodology/Principal Findings We investigated how individuals respond in their spatial behavior toward a highway and its traffic intensity by radio-tracking two common species particularly vulnerable to road mortality (barn owl Tyto alba and stone marten Martes foina). We addressed the following questions: 1) how highways affected home-range location and size in the immediate vicinity of these structures, 2) which road-related features influenced habitat selection, 3) what was the role of different road-related features on movement properties, and 4) which characteristics were associated with crossing events and road-kills. The main findings were: 1) if there was available habitat, barn owls and stone martens may not avoid highways and may even include highways within their home-ranges; 2) both species avoided using areas near the highway when traffic was high, but tended to move toward the highway when streams were in close proximity and where verges offered suitable habitat; and 3) barn owls tended to cross above-grade highway sections while stone martens tended to avoid crossing at leveled highway sections. Conclusions Mortality may be the main road-mediated mechanism that affects barn owl and stone marten populations. Fine-scale movements strongly indicated that a decrease in road mortality risk can be realized by reducing sources of attraction, and by increasing road permeability through measures that promote safe crossings. PMID:22970143

  2. MALDI Mass Spectral Imaging of Bile Acids Observed as Deprotonated Molecules and Proton-Bound Dimers from Mouse Liver Sections

    NASA Astrophysics Data System (ADS)

    Rzagalinski, Ignacy; Hainz, Nadine; Meier, Carola; Tschernig, Thomas; Volmer, Dietrich A.

    2018-02-01

    Bile acids (BAs) play two vital roles in living organisms, as they are involved in (1) the secretion of cholesterol from liver, and (2) the lipid digestion/absorption in the intestine. Abnormal bile acid synthesis or secretion can lead to severe liver disorders. Even though there is extensive literature on the mass spectrometric determination of BAs in biofluids and tissue homogenates, there are no reports on the spatial distribution in the biliary network of the liver. Here, we demonstrate the application of high mass resolution/mass accuracy matrix-assisted laser desorption/ionization (MALDI)-Fourier-transform ion cyclotron resonance (FTICR) to MS imaging (MSI) of BAs at high spatial resolutions (pixel size, 25 μm). The results show chemical heterogeneity of the mouse liver sections with a number of branching biliary and blood ducts. In addition to ion signals from deprotonation of the BA molecules, MALDI-MSI generated several further intense signals at larger m/z for the BAs. These signals were spatially co-localized with the deprotonated molecules and easily misinterpreted as additional products of BA biotransformations. In-depth analysis of accurate mass shifts and additional electrospray ionization and MALDI-FTICR experiments, however, confirmed them as proton-bound dimers. Interestingly, dimers of bile acids, but also unusual mixed dimers of different taurine-conjugated bile acids and free taurine, were identified. Since formation of these complexes will negatively influence signal intensities of the desired [M - H]- ions and significantly complicate mass spectral interpretations, two simple broadband techniques were proposed for non-selective dissociation of dimers that lead to increased signals for the deprotonated BAs. [Figure not available: see fulltext.

  3. Minimizing the Standard Deviation of Spatially Averaged Surface Cross-Sectional Data from the Dual-Frequency Precipitation Radar

    NASA Technical Reports Server (NTRS)

    Meneghini, Robert; Kim, Hyokyung

    2016-01-01

    For an airborne or spaceborne radar, the precipitation-induced path attenuation can be estimated from the measurements of the normalized surface cross section, sigma 0, in the presence and absence of precipitation. In one implementation, the mean rain-free estimate and its variability are found from a lookup table (LUT) derived from previously measured data. For the dual-frequency precipitation radar aboard the global precipitation measurement satellite, the nominal table consists of the statistics of the rain-free 0 over a 0.5 deg x 0.5 deg latitude-longitude grid using a three-month set of input data. However, a problem with the LUT is an insufficient number of samples in many cells. An alternative table is constructed by a stepwise procedure that begins with the statistics over a 0.25 deg x 0.25 deg grid. If the number of samples at a cell is too few, the area is expanded, cell by cell, choosing at each step that cell that minimizes the variance of the data. The question arises, however, as to whether the selected region corresponds to the smallest variance. To address this question, a second type of variable-averaging grid is constructed using all possible spatial configurations and computing the variance of the data within each region. Comparisons of the standard deviations for the fixed and variable-averaged grids are given as a function of incidence angle and surface type using a three-month set of data. The advantage of variable spatial averaging is that the average standard deviation can be reduced relative to the fixed grid while satisfying the minimum sample requirement.

  4. Using temporal ICA to selectively remove global noise while preserving global signal in functional MRI data.

    PubMed

    Glasser, Matthew F; Coalson, Timothy S; Bijsterbosch, Janine D; Harrison, Samuel J; Harms, Michael P; Anticevic, Alan; Van Essen, David C; Smith, Stephen M

    2018-06-02

    Temporal fluctuations in functional Magnetic Resonance Imaging (fMRI) have been profitably used to study brain activity and connectivity for over two decades. Unfortunately, fMRI data also contain structured temporal "noise" from a variety of sources, including subject motion, subject physiology, and the MRI equipment. Recently, methods have been developed to automatically and selectively remove spatially specific structured noise from fMRI data using spatial Independent Components Analysis (ICA) and machine learning classifiers. Spatial ICA is particularly effective at removing spatially specific structured noise from high temporal and spatial resolution fMRI data of the type acquired by the Human Connectome Project and similar studies. However, spatial ICA is mathematically, by design, unable to separate spatially widespread "global" structured noise from fMRI data (e.g., blood flow modulations from subject respiration). No methods currently exist to selectively and completely remove global structured noise while retaining the global signal from neural activity. This has left the field in a quandary-to do or not to do global signal regression-given that both choices have substantial downsides. Here we show that temporal ICA can selectively segregate and remove global structured noise while retaining global neural signal in both task-based and resting state fMRI data. We compare the results before and after temporal ICA cleanup to those from global signal regression and show that temporal ICA cleanup removes the global positive biases caused by global physiological noise without inducing the network-specific negative biases of global signal regression. We believe that temporal ICA cleanup provides a "best of both worlds" solution to the global signal and global noise dilemma and that temporal ICA itself unlocks interesting neurobiological insights from fMRI data. Copyright © 2018 Elsevier Inc. All rights reserved.

  5. Improving the Spatial Prediction of Soil Organic Carbon Stocks in a Complex Tropical Mountain Landscape by Methodological Specifications in Machine Learning Approaches.

    PubMed

    Ließ, Mareike; Schmidt, Johannes; Glaser, Bruno

    2016-01-01

    Tropical forests are significant carbon sinks and their soils' carbon storage potential is immense. However, little is known about the soil organic carbon (SOC) stocks of tropical mountain areas whose complex soil-landscape and difficult accessibility pose a challenge to spatial analysis. The choice of methodology for spatial prediction is of high importance to improve the expected poor model results in case of low predictor-response correlations. Four aspects were considered to improve model performance in predicting SOC stocks of the organic layer of a tropical mountain forest landscape: Different spatial predictor settings, predictor selection strategies, various machine learning algorithms and model tuning. Five machine learning algorithms: random forests, artificial neural networks, multivariate adaptive regression splines, boosted regression trees and support vector machines were trained and tuned to predict SOC stocks from predictors derived from a digital elevation model and satellite image. Topographical predictors were calculated with a GIS search radius of 45 to 615 m. Finally, three predictor selection strategies were applied to the total set of 236 predictors. All machine learning algorithms-including the model tuning and predictor selection-were compared via five repetitions of a tenfold cross-validation. The boosted regression tree algorithm resulted in the overall best model. SOC stocks ranged between 0.2 to 17.7 kg m-2, displaying a huge variability with diffuse insolation and curvatures of different scale guiding the spatial pattern. Predictor selection and model tuning improved the models' predictive performance in all five machine learning algorithms. The rather low number of selected predictors favours forward compared to backward selection procedures. Choosing predictors due to their indiviual performance was vanquished by the two procedures which accounted for predictor interaction.

  6. Selective attention neutralizes the adverse effects of low socioeconomic status on memory in 9-month-old infants

    PubMed Central

    Markant, Julie; Ackerman, Laura K.; Nussenbaum, Kate; Amso, Dima

    2015-01-01

    Socioeconomic status (SES) has a documented impact on brain and cognitive development. We demonstrate that engaging spatial selective attention mechanisms may counteract this negative influence of impoverished environments on early learning. We previously used a spatial cueing task to compare target object encoding in the context of basic orienting (“facilitation”) versus a spatial selective attention orienting mechanism that engages distractor suppression (“IOR”). This work showed that object encoding in the context of IOR boosted 9-month-old infants’ recognition memory relative to facilitation (Markant and Amso, 2013). Here we asked whether this attention-memory links further interacted with SES in infancy. Results indicated that SES was related to memory but not attention orienting efficacy. However, the correlation between SES and memory performance was moderated by the attention mechanism engaged during encoding. SES predicted memory performance when objects were encoded with basic orienting processes, with infants from low-SES environments showing poorer memory than those from high-SES environments. However, SES did not predict memory performance among infants who engaged selective attention during encoding. Spatial selective attention engagement mitigated the effects of SES on memory and may offer an effective mechanism for promoting learning among infants at risk for poor cognitive outcomes related to SES. PMID:26597046

  7. All-dielectric metamaterial frequency selective surface based on spatial arrangement ceramic resonators

    NASA Astrophysics Data System (ADS)

    Li, Liyang; Wang, Jun; Feng, Mingde; Ma, Hua; Wang, Jiafu; Du, Hongliang; Qu, Shaobo

    In this paper, we demonstrate a method of designing all-dielectric metamaterial frequency selective surface (FSS) with ceramic resonators in spatial arrangement. Compared with the traditional way, spatial arrangement provides a flexible way to handle the permutation and combination of different ceramic resonators. With this method, the resonance response can be adjusted easily to achieve pass/stop band effects. As an example, a stop band spatial arrangement all-dielectric metamaterial FSS is designed. Its working band is in 11.65-12.23GHz. By adjusting permittivity and geometrical parameters of ceramic resonators, we can easily modulate the resonances, band pass or band stop characteristic, as well as the working band.

  8. Assessment of Flood Mitigation Solutions Using a Hydrological Model and Refined 2D Hydrodynamic Simulations

    NASA Astrophysics Data System (ADS)

    Khuat Duy, B.; Archambeau, P.; Dewals, B. J.; Erpicum, S.; Pirotton, M.

    2009-04-01

    Following recurrent inundation problems on the Berwinne catchment, in Belgium, a combined hydrologic and hydrodynamic study has been carried out in order to find adequate solutions for the floods mitigation. Thanks to detailed 2D simulations, the effectiveness of the solutions can be assessed not only in terms of discharge and height reductions in the river, but also with other aspects such as the inundated surfaces reduction and the decrease of inundated buildings and roads. The study is carried out in successive phases. First, the hydrological runoffs are generated using a physically based and spatially distributed multi-layer model solving depth-integrated equations for overland flow, subsurface flow and baseflow. Real floods events are simulated using rainfall series collected at 8 stations (over 20 years of available data). The hydrological inputs are routed through the river network (and through the sewage network if relevant) with the 1D component of the modelling system, which solves the Saint-Venant equations for both free-surface and pressurized flows in a unified way. On the main part of the river, the measured river cross-sections are included in the modelling, and existing structures along the river (such as bridges, sluices or pipes) are modelled explicitely with specific cross sections. Two gauging stations with over 15 years of continuous measurements allow the calibration of both the hydrologic and hydrodynamic models. Second, the flood mitigation solutions are tested in the simulations in the case of an extreme flooding event, and their effects are assessed using detailed 2D simulations on a few selected sensitive areas. The digital elevation model comes from an airborne laser survey with a spatial resolution of 1 point per square metre and is completed in the river bed with a bathymetry interpolated from cross-section data. The upstream discharge is extracted from the 1D simulation for the selected rainfall event. The study carried out with this methodology allowed to assess the suggested solutions with multiple effectiveness criteria and therefore constitutes a very useful support for decision makers.

  9. ERP Evidence of Early Cross-Modal Links between Auditory Selective Attention and Visuo-Spatial Memory

    ERIC Educational Resources Information Center

    Bomba, Marie D.; Singhal, Anthony

    2010-01-01

    Previous dual-task research pairing complex visual tasks involving non-spatial cognitive processes during dichotic listening have shown effects on the late component (Ndl) of the negative difference selective attention waveform but no effects on the early (Nde) response suggesting that the Ndl, but not the Nde, is affected by non-spatial…

  10. Movement is the glue connecting home ranges and habitat selection.

    PubMed

    Van Moorter, Bram; Rolandsen, Christer M; Basille, Mathieu; Gaillard, Jean-Michel

    2016-01-01

    Animal space use has been studied by focusing either on geographic (e.g. home ranges, species' distribution) or on environmental (e.g. habitat use and selection) space. However, all patterns of space use emerge from individual movements, which are the primary means by which animals change their environment. Individuals increase their use of a given area by adjusting two key movement components: the duration of their visit and/or the frequency of revisits. Thus, in spatially heterogeneous environments, animals exploit known, high-quality resource areas by increasing their residence time (RT) in and/or decreasing their time to return (TtoR) to these areas. We expected that spatial variation in these two movement properties should lead to observed patterns of space use in both geographic and environmental spaces. We derived a set of nine predictions linking spatial distribution of movement properties to emerging space-use patterns. We predicted that, at a given scale, high variation in RT and TtoR among habitats leads to strong habitat selection and that long RT and short TtoR result in a small home range size. We tested these predictions using moose (Alces alces) GPS tracking data. We first modelled the relationship between landscape characteristics and movement properties. Then, we investigated how the spatial distribution of predicted movement properties (i.e. spatial autocorrelation, mean, and variance of RT and TtoR) influences home range size and hierarchical habitat selection. In landscapes with high spatial autocorrelation of RT and TtoR, a high variation in both RT and TtoR occurred in home ranges. As expected, home range location was highly selective in such landscapes (i.e. second-order habitat selection); RT was higher and TtoR lower within the selected home range than outside, and moose home ranges were small. Within home ranges, a higher variation in both RT and TtoR was associated with higher selectivity among habitat types (i.e. third-order habitat selection). Our findings show how patterns of geographic and environmental space use correspond to the two sides of a coin, linked by movement responses of individuals to environmental heterogeneity. By demonstrating the potential to assess the consequences of altering RT or TtoR (e.g. through human disturbance or climatic changes) on home range size and habitat selection, our work sets the basis for new theoretical and methodological advances in movement ecology. © 2015 The Authors. Journal of Animal Ecology © 2015 British Ecological Society.

  11. Arbitrary cross-section SEM-cathodoluminescence imaging of growth sectors and local carrier concentrations within micro-sampled semiconductor nanorods

    PubMed Central

    Watanabe, Kentaro; Nagata, Takahiro; Oh, Seungjun; Wakayama, Yutaka; Sekiguchi, Takashi; Volk, János; Nakamura, Yoshiaki

    2016-01-01

    Future one-dimensional electronics require single-crystalline semiconductor free-standing nanorods grown with uniform electrical properties. However, this is currently unrealistic as each crystallographic plane of a nanorod grows at unique incorporation rates of environmental dopants, which forms axial and lateral growth sectors with different carrier concentrations. Here we propose a series of techniques that micro-sample a free-standing nanorod of interest, fabricate its arbitrary cross-sections by controlling focused ion beam incidence orientation, and visualize its internal carrier concentration map. ZnO nanorods are grown by selective area homoepitaxy in precursor aqueous solution, each of which has a (0001):+c top-plane and six {1–100}:m side-planes. Near-band-edge cathodoluminescence nanospectroscopy evaluates carrier concentration map within a nanorod at high spatial resolution (60 nm) and high sensitivity. It also visualizes +c and m growth sectors at arbitrary nanorod cross-section and history of local transient growth events within each growth sector. Our technique paves the way for well-defined bottom-up nanoelectronics. PMID:26881966

  12. Selective sweeps in growing microbial colonies

    NASA Astrophysics Data System (ADS)

    Korolev, Kirill S.; Müller, Melanie J. I.; Karahan, Nilay; Murray, Andrew W.; Hallatschek, Oskar; Nelson, David R.

    2012-04-01

    Evolutionary experiments with microbes are a powerful tool to study mutations and natural selection. These experiments, however, are often limited to the well-mixed environments of a test tube or a chemostat. Since spatial organization can significantly affect evolutionary dynamics, the need is growing for evolutionary experiments in spatially structured environments. The surface of a Petri dish provides such an environment, but a more detailed understanding of microbial growth on Petri dishes is necessary to interpret such experiments. We formulate a simple deterministic reaction-diffusion model, which successfully predicts the spatial patterns created by two competing species during colony expansion. We also derive the shape of these patterns analytically without relying on microscopic details of the model. In particular, we find that the relative fitness of two microbial strains can be estimated from the logarithmic spirals created by selective sweeps. The theory is tested with strains of the budding yeast Saccharomyces cerevisiae for spatial competitions with different initial conditions and for a range of relative fitnesses. The reaction-diffusion model also connects the microscopic parameters like growth rates and diffusion constants with macroscopic spatial patterns and predicts the relationship between fitness in liquid cultures and on Petri dishes, which we confirmed experimentally. Spatial sector patterns therefore provide an alternative fitness assay to the commonly used liquid culture fitness assays.

  13. Spatially resolved metabolic analysis reveals a central role for transcriptional control in carbon allocation to wood.

    PubMed

    Roach, Melissa; Arrivault, Stéphanie; Mahboubi, Amir; Krohn, Nicole; Sulpice, Ronan; Stitt, Mark; Niittylä, Totte

    2017-06-15

    The contribution of transcriptional and post-transcriptional regulation to modifying carbon allocation to developing wood of trees is not well defined. To clarify the role of transcriptional regulation, the enzyme activity patterns of eight central primary metabolism enzymes across phloem, cambium, and developing wood of aspen (Populus tremula L.) were compared with transcript levels obtained by RNA sequencing of sequential stem sections from the same trees. Enzymes were selected on the basis of their importance in sugar metabolism and in linking primary metabolism to lignin biosynthesis. Existing enzyme assays were adapted to allow measurements from ~1 mm3 sections of dissected stem tissue. These experiments provided high spatial resolution of enzyme activity changes across different stages of wood development, and identified the gene transcripts probably responsible for these changes. In most cases, there was a clear positive relationship between transcripts and enzyme activity. During secondary cell wall formation, the increases in transcript levels and enzyme activities also matched with increased levels of glucose, fructose, hexose phosphates, and UDP-glucose, emphasizing an important role for transcriptional regulation in carbon allocation to developing aspen wood. These observations corroborate the efforts to increase carbon allocation to wood by engineering gene regulatory networks. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  14. Visual attention: The past 25 years

    PubMed Central

    Carrasco, Marisa

    2012-01-01

    This review focuses on covert attention and how it alters early vision. I explain why attention is considered a selective process, the constructs of covert attention, spatial endogenous and exogenous attention, and feature-based attention. I explain how in the last 25 years research on attention has characterized the effects of covert attention on spatial filters and how attention influences the selection of stimuli of interest. This review includes the effects of spatial attention on discriminability and appearance in tasks mediated by contrast sensitivity and spatial resolution; the effects of feature-based attention on basic visual processes, and a comparison of the effects of spatial and feature-based attention. The emphasis of this review is on psychophysical studies, but relevant electrophysiological and neuroimaging studies and models regarding how and where neuronal responses are modulated are also discussed. PMID:21549742

  15. Visual attention: the past 25 years.

    PubMed

    Carrasco, Marisa

    2011-07-01

    This review focuses on covert attention and how it alters early vision. I explain why attention is considered a selective process, the constructs of covert attention, spatial endogenous and exogenous attention, and feature-based attention. I explain how in the last 25 years research on attention has characterized the effects of covert attention on spatial filters and how attention influences the selection of stimuli of interest. This review includes the effects of spatial attention on discriminability and appearance in tasks mediated by contrast sensitivity and spatial resolution; the effects of feature-based attention on basic visual processes, and a comparison of the effects of spatial and feature-based attention. The emphasis of this review is on psychophysical studies, but relevant electrophysiological and neuroimaging studies and models regarding how and where neuronal responses are modulated are also discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

  16. Does spatial location matter? Traditional therapy utilisation among the general population in a Ghanaian rural and urban setting.

    PubMed

    Gyasi, Razak Mohammed; Asante, Felix; Segbefia, Alexander Yao; Abass, Kabila; Mensah, Charlotte Monica; Siaw, Lawrencia Pokuah; Eshun, Gabriel; Adjei, Prince Osei-Wusu

    2015-06-01

    Despite the recognition for rising consumption rate of traditional medicine (TRM) in health and spatio-medical literature in the global scale, the impact of location in traditional therapy use has been explored least in Ghana. This paper analysed the role of spatial variation in TRM use in Kumasi Metropolis and Sekyere South District of Ashanti Region, Ghana. A retrospective cross-sectional and place-based survey was conducted in a representative sample (N=324) selected through systematic random sampling technique. Structured interviewer-administered questionnaires were espoused as the main research instruments. Data were analysed with Pearson's Chi-square and Fisher's exact tests from the Predictive Analytics Software (PASW) version 17.0. The study found that over 86% reported TRM use. Whilst majority (59.1%) of the respondents had used TRM two or more times within the last 12 months, biologically-based therapies and energy healing were common forms of TRM accessed. Although, the use of TRM did not vary (p>0.05), knowledge about TRM, modalities of TRM and the sources of TRM differed significantly across geographically demarcated rural and urban splits (p<0.005). The study advances our understanding of the spatial dimensions as regards TRM utilisation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Selective white matter pathology induces a specific impairment in spatial working memory.

    PubMed

    Coltman, Robin; Spain, Aisling; Tsenkina, Yanina; Fowler, Jill H; Smith, Jessica; Scullion, Gillian; Allerhand, Mike; Scott, Fiona; Kalaria, Rajesh N; Ihara, Masafumi; Daumas, Stephanie; Deary, Ian J; Wood, Emma; McCulloch, James; Horsburgh, Karen

    2011-12-01

    The integrity of the white matter is critical in regulating efficient neuronal communication and maintaining cognitive function. Damage to brain white matter putatively contributes to age-related cognitive decline. There is a growing interest in animal models from which the mechanistic basis of white matter pathology in aging can be elucidated but to date there has been a lack of systematic behavior and pathology in the same mice. Anatomically widespread, diffuse white matter damage was induced, in 3 different cohorts of C57Bl/6J mice, by chronic hypoperfusion produced by bilateral carotid stenosis. A comprehensive assessment of spatial memory (spatial reference learning and memory; cohort 1) and serial spatial learning and memory (cohort 2) using the water maze, and spatial working memory (cohort 3) using the 8-arm radial arm maze, was conducted. In parallel, a systematic assessment of white matter components (myelin, axon, glia) was conducted using immunohistochemical markers (myelin-associated glycoprotein [MAG], degraded myelin basic protein [dMBP], anti-amyloid precursor protein [APP], anti-ionized calcium-binding adapter molecule [Iba-1]). Ischemic neuronal perikarya damage, assessed using histology (hematoxylin and eosin; H&E), was absent in all shams but was present in some hypoperfused mice (2/11 in cohort 1, 4/14 in cohort 2, and 17/24 in cohort 3). All animals with neuronal perikaryal damage were excluded from further study. Diffuse white matter damage occurred, throughout the brain, in all hypoperfused mice in each cohort and was essentially absent in sham-operated controls. There was a selective impairment in spatial working memory, with all other measures of spatial memory remaining intact, in hypoperfused mice with selective white matter damage. The results demonstrate that diffuse white matter pathology, in the absence of gray matter damage, induces a selective impairment of spatial working memory. This highlights the importance of assessing parallel pathology and behavior in the same mice. Copyright © 2011. Published by Elsevier Inc.

  18. Spatial distribution of planktonic bacterial and archaeal communities in the upper section of the tidal reach in Yangtze River

    PubMed Central

    Fan, Limin; Song, Chao; Meng, Shunlong; Qiu, Liping; Zheng, Yao; Wu, Wei; Qu, Jianhong; Li, Dandan; Zhang, Cong; Hu, Gengdong; Chen, Jiazhang

    2016-01-01

    Bacterioplankton and archaeaplankton communities play key roles in the biogeochemical processes of water, and they may be affected by many factors. In this study, we used high-throughput 16S rRNA gene sequencing to profile planktonic bacterial and archaeal community compositions in the upper section of the tidal reach in Yangtze River. We found that the predominant bacterial phyla in this river section were Proteobacteria, Firmicutes, and Actinobacteria, whereas the predominant archaeal classes were Halobacteria, Methanomicrobia, and unclassified Euryarchaeota. Additionally, the bacterial and archaeal community compositions, richnesses, functional profiles, and ordinations were affected by the spatial heterogeneity related to the concentration changes of sulphate or nitrate. Notably, the bacterial community was more sensitive than the archaeal community to changes in the spatial characteristics of this river section. These findings provide important insights into the distributions of bacterial and archaeal communities in natural water habitats. PMID:27966673

  19. Spatial distribution of planktonic bacterial and archaeal communities in the upper section of the tidal reach in Yangtze River

    NASA Astrophysics Data System (ADS)

    Fan, Limin; Song, Chao; Meng, Shunlong; Qiu, Liping; Zheng, Yao; Wu, Wei; Qu, Jianhong; Li, Dandan; Zhang, Cong; Hu, Gengdong; Chen, Jiazhang

    2016-12-01

    Bacterioplankton and archaeaplankton communities play key roles in the biogeochemical processes of water, and they may be affected by many factors. In this study, we used high-throughput 16S rRNA gene sequencing to profile planktonic bacterial and archaeal community compositions in the upper section of the tidal reach in Yangtze River. We found that the predominant bacterial phyla in this river section were Proteobacteria, Firmicutes, and Actinobacteria, whereas the predominant archaeal classes were Halobacteria, Methanomicrobia, and unclassified Euryarchaeota. Additionally, the bacterial and archaeal community compositions, richnesses, functional profiles, and ordinations were affected by the spatial heterogeneity related to the concentration changes of sulphate or nitrate. Notably, the bacterial community was more sensitive than the archaeal community to changes in the spatial characteristics of this river section. These findings provide important insights into the distributions of bacterial and archaeal communities in natural water habitats.

  20. Propagule Limitation, Disparate Habitat Quality, and Variation in Phenotypic Selection at a Local Species Range Boundary

    PubMed Central

    Moore, Kara A.; Stanton, Maureen L.

    2014-01-01

    Adaptation to novel conditions beyond current range boundaries requires the presence of suitable sites within dispersal range, but may be impeded when emigrants encounter poor habitat and sharply different selection pressures. We investigated fine-scale spatial heterogeneity in ecological dynamics and selection at a local population boundary of the annual plant Gilia tricolor. In two years, we planted G. tricolor seeds in core habitat, margin habitat at the edge of the local range, and exterior habitat in order to measure spatial and temporal variation in habitat quality, opportunity for selection, and selection on phenotypic traits. We found a striking decline in average habitat quality with distance from the population core, yet some migrant seeds were successful in suitable, unoccupied microsites at and beyond the range boundary. Total and direct selection on four out of five measured phenotypic traits varied across habitat zones, as well as between years. Moreover, the margin habitat often exerted unique selection pressures that were not intermediate between core and exterior habitats. This study reveals that a combination of ecological and evolutionary forces, including propagule limitation, variation in habitat quality and spatial heterogeneity in phenotypic selection may reduce opportunities for adaptive range expansion, even across a very local population boundary. PMID:24717472

  1. Coarse-to-Fine Encoding of Spatial Frequency Information into Visual Short-Term Memory for Faces but Impartial Decay

    ERIC Educational Resources Information Center

    Gao, Zaifeng; Bentin, Shlomo

    2011-01-01

    Face perception studies investigated how spatial frequencies (SF) are extracted from retinal display while forming a perceptual representation, or their selective use during task-imposed categorization. Here we focused on the order of encoding low-spatial frequencies (LSF) and high-spatial frequencies (HSF) from perceptual representations into…

  2. Promotion of Spatial Skills in Chemistry and Biochemistry Education at the College Level

    ERIC Educational Resources Information Center

    Oliver-Hoyo, Maria; Babilonia-Rosa, Melissa A.

    2017-01-01

    Decades of research have demonstrated the correlation of spatial abilities to chemistry achievement and career selection. Nonetheless, reviews have highlighted the need and scarcity of explicit spatial instruction to promote spatial skills. Therefore, the goal of this literature review is to summarize what has been done during the past decade in…

  3. Factors influencing reporting and harvest probabilities in North American geese

    USGS Publications Warehouse

    Zimmerman, G.S.; Moser, T.J.; Kendall, W.L.; Doherty, P.F.; White, Gary C.; Caswell, D.F.

    2009-01-01

    We assessed variation in reporting probabilities of standard bands among species, populations, harvest locations, and size classes of North American geese to enable estimation of unbiased harvest probabilities. We included reward (US10,20,30,50, or100) and control (0) banded geese from 16 recognized goose populations of 4 species: Canada (Branta canadensis), cackling (B. hutchinsii), Ross's (Chen rossii), and snow geese (C. caerulescens). We incorporated spatially explicit direct recoveries and live recaptures into a multinomial model to estimate reporting, harvest, and band-retention probabilities. We compared various models for estimating harvest probabilities at country (United States vs. Canada), flyway (5 administrative regions), and harvest area (i.e., flyways divided into northern and southern sections) scales. Mean reporting probability of standard bands was 0.73 (95 CI 0.690.77). Point estimates of reporting probabilities for goose populations or spatial units varied from 0.52 to 0.93, but confidence intervals for individual estimates overlapped and model selection indicated that models with species, population, or spatial effects were less parsimonious than those without these effects. Our estimates were similar to recently reported estimates for mallards (Anas platyrhynchos). We provide current harvest probability estimates for these populations using our direct measures of reporting probability, improving the accuracy of previous estimates obtained from recovery probabilities alone. Goose managers and researchers throughout North America can use our reporting probabilities to correct recovery probabilities estimated from standard banding operations for deriving spatially explicit harvest probabilities.

  4. System of multifunctional laser polarimetry of phase and amplitude anisotropy in the diagnosis of endometriosis

    NASA Astrophysics Data System (ADS)

    Ushenko, Yu. O.; Dubolazov, O. V.; Olar, O. V.

    2015-11-01

    The theoretical background of azimuthally stable method Jones matrix mapping of histological sections of biopsy of uterine neck on the basis of spatial-frequency selection of the mechanisms of linear and circular birefringence is presented. The comparative results of measuring the coordinate distributions of complex degree of mutual anisotropy formed by polycristalline networks of blood plasma layers of donors (group 1) and patients with endometriosis (group 2). The values and ranges of change of the statistical (moments of the 1st - 4th order) parameters of complex degree of mutual anisotropy coordinate distributions are studied. The objective criteria of diagnostics of the pathology and differentiation of its severity degree are determined.

  5. Multifunctional polarization tomography of optical anisotropy of biological layers in diagnosis of endometriosis

    NASA Astrophysics Data System (ADS)

    Ushenko, O. G.; Koval, L. D.; Dubolazov, O. V.; Ushenko, Yu. O.; Savich, V. O.; Sidor, M. I.; Marchuk, Yu. F.

    2015-09-01

    The theoretical background of azimuthally stable method Jones matrix mapping of histological sections of biopsy of uterine neck on the basis of spatial-frequency selection of the mechanisms of linear and circular birefringence is presented. The comparative results of measuring the coordinate distributions of complex degree of mutual anisotropy formed by polycristalline networks of blood plasma layers of donors (group 1) and patients with endometriosis (group 2). The values and ranges of change of the statistical (moments of the 1st - 4th order) parameters of complex degree of mutual anisotropy coordinate distributions are studied. The objective criteria of diagnostics of the pathology and differentiation of its severity degree are determined.

  6. Two dimensional photoacoustic imaging using microfiber interferometric acoustic transducers

    NASA Astrophysics Data System (ADS)

    Wang, Xiu Xin; Li, Zhang Yong; Tian, Yin; Wang, Wei; Pang, Yu; Tam, Kin Yip

    2018-07-01

    Photoacoustic imaging transducer with a pair of wavelength-matched Bragg gratings (forming a Fabry-Perot cavity) inscribed on a short section of microfiber has been developed. A tunable laser with wavelength that matched to one of selected fringe slopes was used to transmit the acoustic induced wavelength. Interferometric fringes with high finesse in transmission significantly enhanced the sensitivity of the transducer even under very small acoustic perturbations. The performance of this novel transducer was evaluated through the imaging studies of human hairs (∼98 μm in diameter). The spatial resolution is 300 μm. We have demonstrated that the novel transducer developed in this study is a versatile tool for photoacoustic imaging study.

  7. Squids in the Study of Cerebral Magnetic Field

    NASA Astrophysics Data System (ADS)

    Romani, G. L.; Narici, L.

    The following sections are included: * INTRODUCTION * HISTORICAL OVERVIEW * NEUROMAGNETIC FIELDS AND AMBIENT NOISE * DETECTORS * Room temperature sensors * SQUIDs * DETECTION COILS * Magnetometers * Gradiometers * Balancing * Planar gradiometers * Choice of the gradiometer parameters * MODELING * Current pattern due to neural excitations * Action potentials and postsynaptic currents * The current dipole model * Neural population and detected fields * Spherically bounded medium * SPATIAL CONFIGURATION OF THE SENSORS * SOURCE LOCALIZATION * Localization procedure * Experimental accuracy and reproducibility * SIGNAL PROCESSING * Analog Filtering * Bandpass filters * Line rejection filters * DATA ANALYSIS * Analysis of evoked/event-related responses * Simple average * Selected average * Recursive techniques * Similarity analysis * Analysis of spontaneous activity * Mapping and localization * EXAMPLES OF NEUROMAGNETIC STUDIES * Neuromagnetic measurements * Studies on the normal brain * Clinical applications * Epilepsy * Tinnitus * CONCLUSIONS * ACKNOWLEDGEMENTS * REFERENCES

  8. Achieving pattern uniformity in plasmonic lithography by spatial frequency selection

    NASA Astrophysics Data System (ADS)

    Liang, Gaofeng; Chen, Xi; Zhao, Qing; Guo, L. Jay

    2018-01-01

    The effects of the surface roughness of thin films and defects on photomasks are investigated in two representative plasmonic lithography systems: thin silver film-based superlens and multilayer-based hyperbolic metamaterial (HMM). Superlens can replicate arbitrary patterns because of its broad evanescent wave passband, which also makes it inherently vulnerable to the roughness of the thin film and imperfections of the mask. On the other hand, the HMM system has spatial frequency filtering characteristics and its pattern formation is based on interference, producing uniform and stable periodic patterns. In this work, we show that the HMM system is more immune to such imperfections due to its function of spatial frequency selection. The analyses are further verified by an interference lithography system incorporating the photoresist layer as an optical waveguide to improve the aspect ratio of the pattern. It is concluded that a system capable of spatial frequency selection is a powerful method to produce deep-subwavelength periodic patterns with high degree of uniformity and fidelity.

  9. Elucidating spatially explicit behavioral landscapes in the Willow Flycatcher

    USGS Publications Warehouse

    Bakian, Amanda V.; Sullivan, Kimberly A.; Paxton, Eben H.

    2012-01-01

    Animal resource selection is a complex, hierarchical decision-making process, yet resource selection studies often focus on the presence and absence of an animal rather than the animal's behavior at resource use locations. In this study, we investigate foraging and vocalization resource selection in a population of Willow Flycatchers, Empidonax traillii adastus, using Bayesian spatial generalized linear models. These models produce “behavioral landscapes” in which space use and resource selection is linked through behavior. Radio telemetry locations were collected from 35 adult Willow Flycatchers (n = 14 males, n = 13 females, and n = 8 unknown sex) over the 2003 and 2004 breeding seasons at Fish Creek, Utah. Results from the 2-stage modeling approach showed that habitat type, perch position, and distance from the arithmetic mean of the home range (in males) or nest site (in females) were important factors influencing foraging and vocalization resource selection. Parameter estimates from the individual-level models indicated high intraspecific variation in the use of the various habitat types and perch heights for foraging and vocalization. On the population level, Willow Flycatchers selected riparian habitat over other habitat types for vocalizing but used multiple habitat types for foraging including mountain shrub, young riparian, and upland forest. Mapping of observed and predicted foraging and vocalization resource selection indicated that the behavior often occurred in disparate areas of the home range. This suggests that multiple core areas may exist in the home ranges of individual flycatchers, and demonstrates that the behavioral landscape modeling approach can be applied to identify spatially and behaviorally distinct core areas. The behavioral landscape approach is applicable to a wide range of animal taxa and can be used to improve our understanding of the spatial context of behavior and resource selection.

  10. Selection of day-roosts by Keen's myotis (Myotis keenii) at multiple spatial scales

    Treesearch

    Julia L. Boland; John P. Hayes; Winston P. Smith; Manuela M. Huso

    2009-01-01

    Keen's myotis (Myotis keenii) has one of the most limited geographic distributions of any species of bat in North America. Because there is little knowledge of its roosting ecology, we examined selection of day-roosts in trees by male and female Keen's myotis at three spatial scales (tree, tree plot, and landscape) on Prince of Wales Island...

  11. Reserve selection with minimum contiguous area restrictions: An application to open space protection planning in suburban Chicago

    Treesearch

    Sandor F. Toth; Robert Haight; Stephanie A. Snyder; Sonney George; James R. Miller; Mark S. Gregory; Adam M. Skibbe

    2009-01-01

    Conservation efforts often require site or parcel selection strategies that lead to spatially cohesive reserves. Although habitat contiguity is thought to be conducive to the persistence of many sensitive species, availability of funding and suitable land may restrict the extent to which this spatial attribute can be pursued in land management or conservation. Using...

  12. Selection of fire-created snags at two spatial scales by cavity-nesting birds

    Treesearch

    Victoria A. Saab; Ree Brannon; Jonathan Dudley; Larry Donohoo; Dave Vanderzanden; Vicky Johnson; Henry Lachowski

    2002-01-01

    We examined the use of snag stands by seven species of cavity-nesting birds from 1994-1998. Selection of snags was studied in logged and unlogged burned forests at two spatial scales: microhabitat (local vegetation characteristics) and landscape (composition and patterning of surrounding vegetation types). We modeled nest occurrence at the landscape scale by using...

  13. Deficits of spatial and task-related attentional selection in mild cognitive impairment and Alzheimer's disease.

    PubMed

    Redel, P; Bublak, P; Sorg, C; Kurz, A; Förstl, H; Müller, H J; Schneider, W X; Perneczky, R; Finke, K

    2012-01-01

    Visual selective attention was assessed with a partial-report task in patients with probable Alzheimer's disease (AD), amnestic mild cognitive impairment (MCI), and healthy elderly controls. Based on Bundesen's "theory of visual attention" (TVA), two parameters were derived: top-down control of attentional selection, representing task-related attentional weighting for prioritizing relevant visual objects, and spatial distribution of attentional weights across the left and the right hemifield. Compared with controls, MCI patients showed significantly reduced top-down controlled selection, which was further deteriorated in AD subjects. Moreover, attentional weighting was significantly unbalanced across hemifields in MCI and tended to be more lateralized in AD. Across MCI and AD patients, carriers of the apolipoprotein E ε4 allele (ApoE4) displayed a leftward spatial bias, which was the more pronounced the younger the ApoE4-positive patients and the earlier disease onset. These results indicate that impaired top-down control may be linked to early dysfunction of fronto-parietal networks. An early temporo-parietal interhemispheric asymmetry might cause a pathological spatial bias which is associated with ApoE4 genotype and may therefore function as early cognitive marker of upcoming AD. Copyright © 2012 Elsevier Inc. All rights reserved.

  14. Similar Processes but Different Environmental Filters for Soil Bacterial and Fungal Community Composition Turnover on a Broad Spatial Scale

    PubMed Central

    Chemidlin Prévost-Bouré, Nicolas; Dequiedt, Samuel; Thioulouse, Jean; Lelièvre, Mélanie; Saby, Nicolas P. A.; Jolivet, Claudy; Arrouays, Dominique; Plassart, Pierre; Lemanceau, Philippe; Ranjard, Lionel

    2014-01-01

    Spatial scaling of microorganisms has been demonstrated over the last decade. However, the processes and environmental filters shaping soil microbial community structure on a broad spatial scale still need to be refined and ranked. Here, we compared bacterial and fungal community composition turnovers through a biogeographical approach on the same soil sampling design at a broad spatial scale (area range: 13300 to 31000 km2): i) to examine their spatial structuring; ii) to investigate the relative importance of environmental selection and spatial autocorrelation in determining their community composition turnover; and iii) to identify and rank the relevant environmental filters and scales involved in their spatial variations. Molecular fingerprinting of soil bacterial and fungal communities was performed on 413 soils from four French regions of contrasting environmental heterogeneity (Landes

  15. Similar processes but different environmental filters for soil bacterial and fungal community composition turnover on a broad spatial scale.

    PubMed

    Chemidlin Prévost-Bouré, Nicolas; Dequiedt, Samuel; Thioulouse, Jean; Lelièvre, Mélanie; Saby, Nicolas P A; Jolivet, Claudy; Arrouays, Dominique; Plassart, Pierre; Lemanceau, Philippe; Ranjard, Lionel

    2014-01-01

    Spatial scaling of microorganisms has been demonstrated over the last decade. However, the processes and environmental filters shaping soil microbial community structure on a broad spatial scale still need to be refined and ranked. Here, we compared bacterial and fungal community composition turnovers through a biogeographical approach on the same soil sampling design at a broad spatial scale (area range: 13300 to 31000 km2): i) to examine their spatial structuring; ii) to investigate the relative importance of environmental selection and spatial autocorrelation in determining their community composition turnover; and iii) to identify and rank the relevant environmental filters and scales involved in their spatial variations. Molecular fingerprinting of soil bacterial and fungal communities was performed on 413 soils from four French regions of contrasting environmental heterogeneity (Landes

  16. Electrode channel selection based on backtracking search optimization in motor imagery brain-computer interfaces.

    PubMed

    Dai, Shengfa; Wei, Qingguo

    2017-01-01

    Common spatial pattern algorithm is widely used to estimate spatial filters in motor imagery based brain-computer interfaces. However, use of a large number of channels will make common spatial pattern tend to over-fitting and the classification of electroencephalographic signals time-consuming. To overcome these problems, it is necessary to choose an optimal subset of the whole channels to save computational time and improve the classification accuracy. In this paper, a novel method named backtracking search optimization algorithm is proposed to automatically select the optimal channel set for common spatial pattern. Each individual in the population is a N-dimensional vector, with each component representing one channel. A population of binary codes generate randomly in the beginning, and then channels are selected according to the evolution of these codes. The number and positions of 1's in the code denote the number and positions of chosen channels. The objective function of backtracking search optimization algorithm is defined as the combination of classification error rate and relative number of channels. Experimental results suggest that higher classification accuracy can be achieved with much fewer channels compared to standard common spatial pattern with whole channels.

  17. An unsupervised technique for optimal feature selection in attribute profiles for spectral-spatial classification of hyperspectral images

    NASA Astrophysics Data System (ADS)

    Bhardwaj, Kaushal; Patra, Swarnajyoti

    2018-04-01

    Inclusion of spatial information along with spectral features play a significant role in classification of remote sensing images. Attribute profiles have already proved their ability to represent spatial information. In order to incorporate proper spatial information, multiple attributes are required and for each attribute large profiles need to be constructed by varying the filter parameter values within a wide range. Thus, the constructed profiles that represent spectral-spatial information of an hyperspectral image have huge dimension which leads to Hughes phenomenon and increases computational burden. To mitigate these problems, this work presents an unsupervised feature selection technique that selects a subset of filtered image from the constructed high dimensional multi-attribute profile which are sufficiently informative to discriminate well among classes. In this regard the proposed technique exploits genetic algorithms (GAs). The fitness function of GAs are defined in an unsupervised way with the help of mutual information. The effectiveness of the proposed technique is assessed using one-against-all support vector machine classifier. The experiments conducted on three hyperspectral data sets show the robustness of the proposed method in terms of computation time and classification accuracy.

  18. Optimizing spatial patterns with sparse filter bands for motor-imagery based brain-computer interface.

    PubMed

    Zhang, Yu; Zhou, Guoxu; Jin, Jing; Wang, Xingyu; Cichocki, Andrzej

    2015-11-30

    Common spatial pattern (CSP) has been most popularly applied to motor-imagery (MI) feature extraction for classification in brain-computer interface (BCI) application. Successful application of CSP depends on the filter band selection to a large degree. However, the most proper band is typically subject-specific and can hardly be determined manually. This study proposes a sparse filter band common spatial pattern (SFBCSP) for optimizing the spatial patterns. SFBCSP estimates CSP features on multiple signals that are filtered from raw EEG data at a set of overlapping bands. The filter bands that result in significant CSP features are then selected in a supervised way by exploiting sparse regression. A support vector machine (SVM) is implemented on the selected features for MI classification. Two public EEG datasets (BCI Competition III dataset IVa and BCI Competition IV IIb) are used to validate the proposed SFBCSP method. Experimental results demonstrate that SFBCSP help improve the classification performance of MI. The optimized spatial patterns by SFBCSP give overall better MI classification accuracy in comparison with several competing methods. The proposed SFBCSP is a potential method for improving the performance of MI-based BCI. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Attraction of position preference by spatial attention throughout human visual cortex.

    PubMed

    Klein, Barrie P; Harvey, Ben M; Dumoulin, Serge O

    2014-10-01

    Voluntary spatial attention concentrates neural resources at the attended location. Here, we examined the effects of spatial attention on spatial position selectivity in humans. We measured population receptive fields (pRFs) using high-field functional MRI (fMRI) (7T) while subjects performed an attention-demanding task at different locations. We show that spatial attention attracts pRF preferred positions across the entire visual field, not just at the attended location. This global change in pRF preferred positions systematically increases up the visual hierarchy. We model these pRF preferred position changes as an interaction between two components: an attention field and a pRF without the influence of attention. This computational model suggests that increasing effects of attention up the hierarchy result primarily from differences in pRF size and that the attention field is similar across the visual hierarchy. A similar attention field suggests that spatial attention transforms different neural response selectivities throughout the visual hierarchy in a similar manner. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. Method for crystal growth control

    DOEpatents

    Yates, Douglas A.; Hatch, Arthur E.; Goldsmith, Jeff M.

    1981-01-01

    The growth of a crystalline body of a selected material is controlled so that the body has a selected cross-sectional shape. The apparatus is of the type which includes the structure normally employed in known capillary die devices as well as means for observing at least the portion of the surfaces of the growing crystalline body and the meniscus (of melt material from which the body is being pulled) including the solid/liquid/vapor junction in a direction substantially perpendicular to the meniscus surface formed at the junction when the growth of the crystalline body is under steady state conditions. The cross-sectional size of the growing crystalline body can be controlled by determining which points exhibit a sharp change in the amount of reflected radiation of a preselected wavelength and controlling the speed at which the body is being pulled or the temperature of the growth pool of melt so as to maintain those points exhibiting a sharp change at a preselected spatial position relative to a predetermined reference position. The improvement comprises reference object means positioned near the solid/liquid/vapor junction and capable of being observed by the means for observing so as to define said reference position so that the problems associated with convection current jitter are overcome.

  1. Neural representation of objects in space: a dual coding account.

    PubMed Central

    Humphreys, G W

    1998-01-01

    I present evidence on the nature of object coding in the brain and discuss the implications of this coding for models of visual selective attention. Neuropsychological studies of task-based constraints on: (i) visual neglect; and (ii) reading and counting, reveal the existence of parallel forms of spatial representation for objects: within-object representations, where elements are coded as parts of objects, and between-object representations, where elements are coded as independent objects. Aside from these spatial codes for objects, however, the coding of visual space is limited. We are extremely poor at remembering small spatial displacements across eye movements, indicating (at best) impoverished coding of spatial position per se. Also, effects of element separation on spatial extinction can be eliminated by filling the space with an occluding object, indicating that spatial effects on visual selection are moderated by object coding. Overall, there are separate limits on visual processing reflecting: (i) the competition to code parts within objects; (ii) the small number of independent objects that can be coded in parallel; and (iii) task-based selection of whether within- or between-object codes determine behaviour. Between-object coding may be linked to the dorsal visual system while parallel coding of parts within objects takes place in the ventral system, although there may additionally be some dorsal involvement either when attention must be shifted within objects or when explicit spatial coding of parts is necessary for object identification. PMID:9770227

  2. Optimization of Decision-Making for Spatial Sampling in the North China Plain, Based on Remote-Sensing a Priori Knowledge

    NASA Astrophysics Data System (ADS)

    Feng, J.; Bai, L.; Liu, S.; Su, X.; Hu, H.

    2012-07-01

    In this paper, the MODIS remote sensing data, featured with low-cost, high-timely and moderate/low spatial resolutions, in the North China Plain (NCP) as a study region were firstly used to carry out mixed-pixel spectral decomposition to extract an useful regionalized indicator parameter (RIP) (i.e., an available ratio, that is, fraction/percentage, of winter wheat planting area in each pixel as a regionalized indicator variable (RIV) of spatial sampling) from the initial selected indicators. Then, the RIV values were spatially analyzed, and the spatial structure characteristics (i.e., spatial correlation and variation) of the NCP were achieved, which were further processed to obtain the scalefitting, valid a priori knowledge or information of spatial sampling. Subsequently, founded upon an idea of rationally integrating probability-based and model-based sampling techniques and effectively utilizing the obtained a priori knowledge or information, the spatial sampling models and design schemes and their optimization and optimal selection were developed, as is a scientific basis of improving and optimizing the existing spatial sampling schemes of large-scale cropland remote sensing monitoring. Additionally, by the adaptive analysis and decision strategy the optimal local spatial prediction and gridded system of extrapolation results were able to excellently implement an adaptive report pattern of spatial sampling in accordance with report-covering units in order to satisfy the actual needs of sampling surveys.

  3. Use of Dynamic Visualizations for Engineering Technology, Industrial Technology, and Science Education Students: Implications on Ability to Correctly Create a Sectional View Sketch

    ERIC Educational Resources Information Center

    Katsioloudis, Petros; Dickerson, Daniel; Jovanovic, Vukica; Jones, Mildred V.

    2016-01-01

    Spatial abilities, specifically visualization, play a significant role in the achievement in a wide array of professions including, but not limited to, engineering, technical, mathematical, and scientific professions. However, there is little correlation between the advantages of spatial ability as measured through the creation of a sectional-view…

  4. Selecting and Designing Questions to Facilitate Spatial Thinking

    ERIC Educational Resources Information Center

    Jo, Injeong; Bednarz, Sarah; Metoyer, Sandra

    2010-01-01

    One measure of the impact of a new idea in geography education is how well it is incorporated into teachers' everyday practice. "Spatial thinking" is not really a new idea in geography education; spatial analysis has long been one of its core traditions, but the use of the term is novel and only beginning to be widely used. By spatial thinking the…

  5. Investigation of the Relationship between the Spatial Visualization Success and Visual/Spatial Intelligence Capabilities of Sixth Grade Students

    ERIC Educational Resources Information Center

    Yenilmez, Kursat; Kakmaci, Ozlem

    2015-01-01

    The main aim of this research was to examine the relationship between the spatial visualization success and visual/spatial intelligence capabilities of sixth grade students. The sample of the research consists of 1011 sixth grade students who were randomly selected from the primary schools in Eskisehir. In this correlational study, data were…

  6. Representation of Non-Spatial and Spatial Information in the Lateral Entorhinal Cortex

    PubMed Central

    Deshmukh, Sachin S.; Knierim, James J.

    2011-01-01

    Some theories of memory propose that the hippocampus integrates the individual items and events of experience within a contextual or spatial framework. The hippocampus receives cortical input from two major pathways: the medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC). During exploration in an open field, the firing fields of MEC grid cells form a periodically repeating, triangular array. In contrast, LEC neurons show little spatial selectivity, and it has been proposed that the LEC may provide non-spatial input to the hippocampus. Here, we recorded MEC and LEC neurons while rats explored an open field that contained discrete objects. LEC cells fired selectively at locations relative to the objects, whereas MEC cells were weakly influenced by the objects. These results provide the first direct demonstration of a double dissociation between LEC and MEC inputs to the hippocampus under conditions of exploration typically used to study hippocampal place cells. PMID:22065409

  7. [Effects of the neurogenesis stimulator Ro 25-6981 upon formation of spatial skill in adult rats depend on the term of its administration and the animals' ability to learn].

    PubMed

    Solov'eva, O A; Storozheva, Z I; Proshin, A T; Sherstnev, V V

    2011-02-01

    Effect of administration of selective N-methyl-D-aspartate (NMDA) receptor antagonist Ro 25-6981 on learning and memory in a dose which is known to stimulate neoneurogenesis was assessed in adult rats with different abilities to formation of spatial skills in different time periods after the antagonist injection. Wistar male rats were trained to find hidden platform in the Morris water maze for 5 consecutive days. Rats' learning ability for spatial skill formation was evaluated depending on platform speed achievements. In re-training sessions (cues and platform location changed), it was found that all rats received Ro 25-6981 13 days before the re-training demonstrated impaired spatial memory. At the same time the inhibitor injected 29 days before re-training selectively facilitated the formation of spatial skill in animals with initially low learning abilities.

  8. Spatially localized motion aftereffect disappears faster from awareness when selectively attended to according to its direction.

    PubMed

    Murd, Carolina; Bachmann, Talis

    2011-05-25

    In searching for the target-afterimage patch among spatially separate alternatives of color-afterimages the target fades from awareness before its competitors (Bachmann, T., & Murd, C. (2010). Covert spatial attention in search for the location of a color-afterimage patch speeds up its decay from awareness: Introducing a method useful for the study of neural correlates of visual awareness. Vision Research 50, 1048-1053). In an analogous study presented here we show that a similar effect is obtained when a target spatial location specified according to the direction of motion aftereffect within it is searched by covert top-down attention. The adverse effect of selective attention on the duration of awareness of sensory qualiae known earlier to be present for color and periodic spatial contrast is extended also to sensory channels carrying motion information. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Anatomical constraints on attention: Hemifield independence is a signature of multifocal spatial selection

    PubMed Central

    Alvarez, George A; Gill, Jonathan; Cavanagh, Patrick

    2012-01-01

    Previous studies have shown independent attentional selection of targets in the left and right visual hemifields during attentional tracking (Alvarez & Cavanagh, 2005) but not during a visual search (Luck, Hillyard, Mangun, & Gazzaniga, 1989). Here we tested whether multifocal spatial attention is the critical process that operates independently in the two hemifields. It is explicitly required in tracking (attend to a subset of object locations, suppress the others) but not in the standard visual search task (where all items are potential targets). We used a modified visual search task in which observers searched for a target within a subset of display items, where the subset was selected based on location (Experiments 1 and 3A) or based on a salient feature difference (Experiments 2 and 3B). The results show hemifield independence in this subset visual search task with location-based selection but not with feature-based selection; this effect cannot be explained by general difficulty (Experiment 4). Combined, these findings suggest that hemifield independence is a signature of multifocal spatial attention and highlight the need for cognitive and neural theories of attention to account for anatomical constraints on selection mechanisms. PMID:22637710

  10. Selective attention neutralizes the adverse effects of low socioeconomic status on memory in 9-month-old infants.

    PubMed

    Markant, Julie; Ackerman, Laura K; Nussenbaum, Kate; Amso, Dima

    2016-04-01

    Socioeconomic status (SES) has a documented impact on brain and cognitive development. We demonstrate that engaging spatial selective attention mechanisms may counteract this negative influence of impoverished environments on early learning. We previously used a spatial cueing task to compare target object encoding in the context of basic orienting ("facilitation") versus a spatial selective attention orienting mechanism that engages distractor suppression ("IOR"). This work showed that object encoding in the context of IOR boosted 9-month-old infants' recognition memory relative to facilitation (Markant and Amso, 2013). Here we asked whether this attention-memory link further interacted with SES in infancy. Results indicated that SES was related to memory but not attention orienting efficacy. However, the correlation between SES and memory performance was moderated by the attention mechanism engaged during encoding. SES predicted memory performance when objects were encoded with basic orienting processes, with infants from low-SES environments showing poorer memory than those from high-SES environments. However, SES did not predict memory performance among infants who engaged selective attention during encoding. Spatial selective attention engagement mitigated the effects of SES on memory and may offer an effective mechanism for promoting learning among infants at risk for poor cognitive outcomes related to SES. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  11. Decision Making on Regional Landfill Site Selection in Hormozgan Province Using Smce

    NASA Astrophysics Data System (ADS)

    Majedi, A. S.; Kamali, B. M.; Maghsoudi, R.

    2015-12-01

    Landfill site selection and suitable conditions to bury hazardous wastes are among the most critical issues in modern societies. Taking several factors and limitations into account along with true decision making requires application of different decision techniques. To this end, current paper aims to make decisions about regional landfill site selection in Hormozgan province and utilizes SMCE technique combined with qualitative and quantitative criteria to select the final alternatives. To this respect, we first will describe the existing environmental situation in our study area and set the goals of our study in the framework of SMCE and will analyze the effective factors in regional landfill site selection. Then, methodological procedure of research was conducted using Delphi approach and questionnaires (in order to determine research validity, Chronbach Alpha (0.94) method was used). Spatial multi-criteria analysis model was designed in the form of criteria tree in SMCE using IL WIS software. Prioritization of respective spatial alternatives included: Bandar Abbas city with total 4 spatial alternatives (one zone with 1st priority, one zone with 3rd priority and two zones with 4thpriority) was considered the first priority, Bastak city with total 3 spatial alternatives (one zone with 2nd priority, one zone with 3rdpriorit and one zone with 4th priority) was the second priority and Bandar Abbas, Minab, Jask and Haji Abad cities were considered as the third priority.

  12. Histomolecular interpretation of pleomorphic adenomas of the salivary gland by matrix-assisted laser desorption ionization imaging and spatial segmentation.

    PubMed

    Ernst, Günther; Guntinas-Lichius, Orlando; Hauberg-Lotte, Lena; Trede, Dennis; Becker, Michael; Alexandrov, Theodore; von Eggeling, Ferdinand

    2015-07-01

    Despite efforts in localization of key proteins using immunohistochemistry, the complex proteomic composition of pleomorphic adenomas has not yet been characterized. Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI imaging) allows label-free and spatially resolved detection of hundreds of proteins directly from tissue sections and of histomorphological regions by finding colocalized molecular signals. Spatial segmentation of MALDI imaging data is an algorithmic method for finding regions of similar proteomic composition as functionally similar regions. We investigated 2 pleomorphic adenomas by applying spatial segmentation to the MALDI imaging data of tissue sections. The spatial segmentation subdivided the tissue in a good accordance with the tissue histology. Numerous molecular signals colocalized with histologically defined tissue regions were found. Our study highlights the cellular transdifferentiation within the pleomorphic adenoma. It could be shown that spatial segmentation of MALDI imaging data is a promising approach in the emerging field of digital histological analysis and characterization of tumors. © 2014 Wiley Periodicals, Inc.

  13. A one-dimensional sectional model to simulate multicomponent aerosol dynamics in the marine boundary layer 3. Numerical methods and comparisons with exact solutions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gelbard, F.; Fitzgerald, J.W.; Hoppel, W.A.

    1998-07-01

    We present the theoretical framework and computational methods that were used by {ital Fitzgerald} {ital et al.} [this issue (a), (b)] describing a one-dimensional sectional model to simulate multicomponent aerosol dynamics in the marine boundary layer. The concepts and limitations of modeling spatially varying multicomponent aerosols are elucidated. New numerical sectional techniques are presented for simulating multicomponent aerosol growth, settling, and eddy transport, coupled to time-dependent and spatially varying condensing vapor concentrations. Comparisons are presented with new exact solutions for settling and particle growth by simultaneous dynamic condensation of one vapor and by instantaneous equilibration with a spatially varying secondmore » vapor. {copyright} 1998 American Geophysical Union« less

  14. Topology-selective jamming of fully-connected, code-division random-access networks

    NASA Technical Reports Server (NTRS)

    Polydoros, Andreas; Cheng, Unjeng

    1990-01-01

    The purpose is to introduce certain models of topology selective stochastic jamming and examine its impact on a class of fully-connected, spread-spectrum, slotted ALOHA-type random access networks. The theory covers dedicated as well as half-duplex units. The dominant role of the spatial duty factor is established, and connections with the dual concept of time selective jamming are discussed. The optimal choices of coding rate and link access parameters (from the users' side) and the jamming spatial fraction are numerically established for DS and FH spreading.

  15. Spatially selective formation of hydrocarbon, fluorocarbon, and hydroxyl-terminated monolayers on a microelectrode array.

    PubMed

    Cook, Kevin M; Nissley, Daniel A; Ferguson, Gregory S

    2013-06-11

    A protection-deprotection strategy, using gold oxide as a passivating layer, was used to direct the self-assembly of monolayers (SAMs) selectively at individual gold microelectrodes in an array. This approach allowed the formation of hydroxyl-terminated monolayers, without side reactions, in addition to hydrocarbon and fluorocarbon SAMs. Fluorescence microscopy was used to visualize selective dewetting of hydrophobic monolayers by an aqueous dye solution, and spatially resolved X-ray photoelectron spectroscopy was used to demonstrate a lack of cross-contamination on neighboring microelectrodes in the array.

  16. Vestibular stimulation, spatial hemineglect and dysphasia, selective effects.

    PubMed

    Vallar, G; Papagno, C; Rusconi, M L; Bisiach, E

    1995-09-01

    The selectivity of the effects of vestibular stimulation was investigated in a left brain-damaged patient suffering from right visuo-spatial hemineglect and severe dysplasia. Vestibular stimulation temporarily improved the former but not the latter disorder. These results support the view that this treatment improves hemineglect by a specific effect, running counter the rightward distortion of egocentric co-ordinates, rather than by a general hemispheric activation.

  17. Resource selection by elk at two spatial scales in the Black Hills, South Dakota

    Treesearch

    Mark A. Rumble; R. Scott Gamo

    2011-01-01

    Understanding resource selection by elk (Cervus elaphus) at multiple spatial scales may provide information that will help resolve the increasing number of resource conflicts involving elk. We quantified vegetation at 412 sites where the precise location of elk was known by direct observation and 509 random sites in the Black Hills of South Dakota during 1998-2001. We...

  18. Periodical cicadas use light for oviposition site selection.

    PubMed

    Yang, Louie H

    2006-12-07

    Organisms use incomplete information from local experience to assess the suitability of potential habitat sites over a wide range of spatial and temporal scales. Although ecologists have long recognized the importance of spatial scales in habitat selection, few studies have investigated the temporal scales of habitat selection. In particular, cues in the immediate environment may commonly provide indirect information about future habitat quality. In periodical cicadas (Magicicada spp.), oviposition site selection represents a very long-term habitat choice. Adult female cicadas insert eggs into tree branches during a few weeks in the summer of emergence, but their oviposition choices determine the underground habitats of root-feeding nymphs over the following 13 or 17 years. Here, field experiments are used to show that female cicadas use the local light environment of host trees during the summer of emergence to select long-term host trees. Light environments may also influence oviposition microsite selection within hosts, suggesting a potential behavioural mechanism for associating solar cues with host trees. In contrast, experimental nutrient enrichment of host trees did not influence cicada oviposition densities. These findings suggest that the light environments around host trees may provide a robust predictor of host tree quality in the near future. This habitat selection may influence the spatial distribution of several cicada-mediated ecological processes in eastern North American forests.

  19. Periodical cicadas use light for oviposition site selection

    PubMed Central

    Yang, Louie H

    2006-01-01

    Organisms use incomplete information from local experience to assess the suitability of potential habitat sites over a wide range of spatial and temporal scales. Although ecologists have long recognized the importance of spatial scales in habitat selection, few studies have investigated the temporal scales of habitat selection. In particular, cues in the immediate environment may commonly provide indirect information about future habitat quality. In periodical cicadas (Magicicada spp.), oviposition site selection represents a very long-term habitat choice. Adult female cicadas insert eggs into tree branches during a few weeks in the summer of emergence, but their oviposition choices determine the underground habitats of root-feeding nymphs over the following 13 or 17 years. Here, field experiments are used to show that female cicadas use the local light environment of host trees during the summer of emergence to select long-term host trees. Light environments may also influence oviposition microsite selection within hosts, suggesting a potential behavioural mechanism for associating solar cues with host trees. In contrast, experimental nutrient enrichment of host trees did not influence cicada oviposition densities. These findings suggest that the light environments around host trees may provide a robust predictor of host tree quality in the near future. This habitat selection may influence the spatial distribution of several cicada-mediated ecological processes in eastern North American forests. PMID:17015354

  20. Denitrification potential of riparian soils in relation to multiscale spatial environmental factors: a case study of a typical watershed, China.

    PubMed

    Wei, Jianbing; Feng, Hao; Cheng, Quanguo; Gao, Shiqian; Liu, Haiyan

    2017-02-01

    The objective of this study was to test the hypothesis that environmental regulators of riparian zone soil denitrification potential differ according to spatial scale within a watershed; consequently, a second objective was to provide spatial strategies for conserving and restoring the purification function of runoff in riparian ecosystems. The results show that soil denitrification in riparian zones was more heterogeneous at the profile scale than at the cross-section and landscape scales. At the profile scale, biogeochemical factors (including soil total organic carbon, total nitrogen, and nitrate-nitrogen) were the major direct regulators of the spatial distribution of soil denitrification enzyme activity (DEA). At the cross-section scale, factors included distance from river bank and vegetation density, while landscape-scale factors, including topographic index, elevation, and land use types, indirectly regulated the spatial distribution of DEA. At the profile scale, soil DEA was greatest in the upper soil layers. At the cross-section scale, maximum soil DEA occurred in the mid-part of the riparian zone. At the landscape scale, soil DEA showed an increasing trend towards downstream sites, except for those in urbanized areas.

  1. Experimental comparison of high-density scintillators for EMCCD-based gamma ray imaging

    NASA Astrophysics Data System (ADS)

    Heemskerk, Jan W. T.; Kreuger, Rob; Goorden, Marlies C.; Korevaar, Marc A. N.; Salvador, Samuel; Seeley, Zachary M.; Cherepy, Nerine J.; van der Kolk, Erik; Payne, Stephen A.; Dorenbos, Pieter; Beekman, Freek J.

    2012-07-01

    Detection of x-rays and gamma rays with high spatial resolution can be achieved with scintillators that are optically coupled to electron-multiplying charge-coupled devices (EMCCDs). These can be operated at typical frame rates of 50 Hz with low noise. In such a set-up, scintillation light within each frame is integrated after which the frame is analyzed for the presence of scintillation events. This method allows for the use of scintillator materials with relatively long decay times of a few milliseconds, not previously considered for use in photon-counting gamma cameras, opening up an unexplored range of dense scintillators. In this paper, we test CdWO4 and transparent polycrystalline ceramics of Lu2O3:Eu and (Gd,Lu)2O3:Eu as alternatives to currently used CsI:Tl in order to improve the performance of EMCCD-based gamma cameras. The tested scintillators were selected for their significantly larger cross-sections at 140 keV (99mTc) compared to CsI:Tl combined with moderate to good light yield. A performance comparison based on gamma camera spatial and energy resolution was done with all tested scintillators having equal (66%) interaction probability at 140 keV. CdWO4, Lu2O3:Eu and (Gd,Lu)2O3:Eu all result in a significantly improved spatial resolution over CsI:Tl, albeit at the cost of reduced energy resolution. Lu2O3:Eu transparent ceramic gives the best spatial resolution: 65 µm full-width-at-half-maximum (FWHM) compared to 147 µm FWHM for CsI:Tl. In conclusion, these ‘slow’ dense scintillators open up new possibilities for improving the spatial resolution of EMCCD-based scintillation cameras.

  2. Prevalence and spatial distribution of Theileria parva in cattle under crop-livestock farming systems in Tororo District, Eastern Uganda

    PubMed Central

    2014-01-01

    Background Tick-borne diseases (TBDs) present a major economic burden to communities across East Africa. Farmers in East Africa must use acaracides to target ticks and prevent transmission of tick-borne diseases such as anaplasmosis, babesiosis, cowdriosis and theileriosis; the major causes of cattle mortality and morbidity. The costs of controlling East Coast Fever (ECF), caused by Theileria parva, in Uganda are significant and measures taken to control ticks, to be cost-effective, should take into account the burden of disease. The aim of the present work was to estimate the burden presented by T. parva and its spatial distribution in a crop-livestock production system in Eastern Uganda. Methods A cross sectional study was carried out to determine the prevalence and spatial distribution of T. parva in Tororo District, Uganda. Blood samples were taken from all cattle (n: 2,658) in 22 randomly selected villages across Tororo District from September to December 2011. Samples were analysed by PCR and T. parva prevalence and spatial distribution determined. Results The overall prevalence of T. parva was found to be 5.3%. Herd level prevalence ranged from 0% to 21% with majority of the infections located in the North, North-Eastern and South-Eastern parts of Tororo District. No statistically significant differences in risk of infection were found between age classes, sex and cattle breed. Conclusions T. parva infection is widely distributed in Tororo District, Uganda. The prevalence and distribution of T. parva is most likely determined by spatial distribution of R. appendiculatus, restricted grazing of calves and preferential tick control targeting draft animals. PMID:24589227

  3. Structure Mapping in Autism Spectrum Disorder: Levels of Information Processing and Relations to Executive Functions.

    PubMed

    Hetzroni, Orit E; Shalahevich, Kiril

    2018-03-01

    Analogical reasoning was investigated among children with autism spectrum disorders (ASD) without intellectual disabilities and typical development (TD). Children were asked to select one of two targets in two conditions: (1) with and without spatial structure similarity; (2) with and without a perceptual distractor. Results demonstrate that children with ASD were able to select targets based on structural similarity, but this ability decreased to chance level when presented with a perceptual distractor. Everyday executive functions were positively correlated with structural selections among children with ASD. Results suggest that although children with ASD were able to select based on systematicity principle, perceptual distractor decreased their selection so that their cognitive system produced less structure similarities, that negatively affects spatial analogical reasoning.

  4. Frontal and parietal theta burst TMS impairs working memory for visual-spatial conjunctions

    PubMed Central

    Morgan, Helen M.; Jackson, Margaret C.; van Koningsbruggen, Martijn G.; Shapiro, Kimron L.; Linden, David E.J.

    2013-01-01

    In tasks that selectively probe visual or spatial working memory (WM) frontal and posterior cortical areas show a segregation, with dorsal areas preferentially involved in spatial (e.g. location) WM and ventral areas in visual (e.g. object identity) WM. In a previous fMRI study [1], we showed that right parietal cortex (PC) was more active during WM for orientation, whereas left inferior frontal gyrus (IFG) was more active during colour WM. During WM for colour-orientation conjunctions, activity in these areas was intermediate to the level of activity for the single task preferred and non-preferred information. To examine whether these specialised areas play a critical role in coordinating visual and spatial WM to perform a conjunction task, we used theta burst transcranial magnetic stimulation (TMS) to induce a functional deficit. Compared to sham stimulation, TMS to right PC or left IFG selectively impaired WM for conjunctions but not single features. This is consistent with findings from visual search paradigms, in which frontal and parietal TMS selectively affects search for conjunctions compared to single features, and with combined TMS and functional imaging work suggesting that parietal and frontal regions are functionally coupled in tasks requiring integration of visual and spatial information. Our results thus elucidate mechanisms by which the brain coordinates spatially segregated processing streams and have implications beyond the field of working memory. PMID:22483548

  5. Frontal and parietal theta burst TMS impairs working memory for visual-spatial conjunctions.

    PubMed

    Morgan, Helen M; Jackson, Margaret C; van Koningsbruggen, Martijn G; Shapiro, Kimron L; Linden, David E J

    2013-03-01

    In tasks that selectively probe visual or spatial working memory (WM) frontal and posterior cortical areas show a segregation, with dorsal areas preferentially involved in spatial (e.g. location) WM and ventral areas in visual (e.g. object identity) WM. In a previous fMRI study [1], we showed that right parietal cortex (PC) was more active during WM for orientation, whereas left inferior frontal gyrus (IFG) was more active during colour WM. During WM for colour-orientation conjunctions, activity in these areas was intermediate to the level of activity for the single task preferred and non-preferred information. To examine whether these specialised areas play a critical role in coordinating visual and spatial WM to perform a conjunction task, we used theta burst transcranial magnetic stimulation (TMS) to induce a functional deficit. Compared to sham stimulation, TMS to right PC or left IFG selectively impaired WM for conjunctions but not single features. This is consistent with findings from visual search paradigms, in which frontal and parietal TMS selectively affects search for conjunctions compared to single features, and with combined TMS and functional imaging work suggesting that parietal and frontal regions are functionally coupled in tasks requiring integration of visual and spatial information. Our results thus elucidate mechanisms by which the brain coordinates spatially segregated processing streams and have implications beyond the field of working memory. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Standard Deviation of Spatially-Averaged Surface Cross Section Data from the TRMM Precipitation Radar

    NASA Technical Reports Server (NTRS)

    Meneghini, Robert; Jones, Jeffrey A.

    2010-01-01

    We investigate the spatial variability of the normalized radar cross section of the surface (NRCS or Sigma(sup 0)) derived from measurements of the TRMM Precipitation Radar (PR) for the period from 1998 to 2009. The purpose of the study is to understand the way in which the sample standard deviation of the Sigma(sup 0) data changes as a function of spatial resolution, incidence angle, and surface type (land/ocean). The results have implications regarding the accuracy by which the path integrated attenuation from precipitation can be inferred by the use of surface scattering properties.

  7. Use of remote sensing to identify spatial risk factors for malaria in a region of declining transmission: a cross-sectional and longitudinal community survey.

    PubMed

    Moss, William J; Hamapumbu, Harry; Kobayashi, Tamaki; Shields, Timothy; Kamanga, Aniset; Clennon, Julie; Mharakurwa, Sungano; Thuma, Philip E; Glass, Gregory

    2011-06-10

    The burden of malaria has decreased dramatically within the past several years in parts of sub-Saharan Africa. Further malaria control will require targeted control strategies based on evidence of risk. The objective of this study was to identify environmental risk factors for malaria transmission using remote sensing technologies to guide malaria control interventions in a region of declining burden of malaria. Satellite images were used to construct a sampling frame for the random selection of households enrolled in prospective longitudinal and cross-sectional surveys of malaria parasitaemia in Southern Province, Zambia. A digital elevation model (DEM) was derived from the Shuttle Radar Topography Mission version 3 DEM and used for landscape characterization, including landforms, elevation, aspect, slope, topographic wetness, topographic position index and hydrological models of stream networks. A total of 768 individuals from 128 randomly selected households were enrolled over 21 months, from the end of the rainy season in April 2007 through December 2008. Of the 768 individuals tested, 117 (15.2%) were positive by malaria rapid diagnostic test (RDT). Individuals residing within 3.75 km of a third order stream were at increased risk of malaria. Households at elevations above the baseline elevation for the region were at decreasing risk of having RDT-positive residents. Households where new infections occurred were overlaid on a risk map of RDT positive households and incident infections were more likely to be located in high-risk areas derived from prevalence data. Based on the spatial risk map, targeting households in the top 80th percentile of malaria risk would require malaria control interventions directed to only 24% of the households. Remote sensing technologies can be used to target malaria control interventions in a region of declining malaria transmission in southern Zambia, enabling a more efficient use of resources for malaria elimination.

  8. Evaluation of entropy and JM-distance criterions as features selection methods using spectral and spatial features derived from LANDSAT images

    NASA Technical Reports Server (NTRS)

    Parada, N. D. J. (Principal Investigator); Dutra, L. V.; Mascarenhas, N. D. A.; Mitsuo, Fernando Augusta, II

    1984-01-01

    A study area near Ribeirao Preto in Sao Paulo state was selected, with predominance in sugar cane. Eight features were extracted from the 4 original bands of LANDSAT image, using low-pass and high-pass filtering to obtain spatial features. There were 5 training sites in order to acquire the necessary parameters. Two groups of four channels were selected from 12 channels using JM-distance and entropy criterions. The number of selected channels was defined by physical restrictions of the image analyzer and computacional costs. The evaluation was performed by extracting the confusion matrix for training and tests areas, with a maximum likelihood classifier, and by defining performance indexes based on those matrixes for each group of channels. Results show that in spatial features and supervised classification, the entropy criterion is better in the sense that allows a more accurate and generalized definition of class signature. On the other hand, JM-distance criterion strongly reduces the misclassification within training areas.

  9. Developing a spatial-statistical model and map of historical malaria prevalence in Botswana using a staged variable selection procedure

    PubMed Central

    Craig, Marlies H; Sharp, Brian L; Mabaso, Musawenkosi LH; Kleinschmidt, Immo

    2007-01-01

    Background Several malaria risk maps have been developed in recent years, many from the prevalence of infection data collated by the MARA (Mapping Malaria Risk in Africa) project, and using various environmental data sets as predictors. Variable selection is a major obstacle due to analytical problems caused by over-fitting, confounding and non-independence in the data. Testing and comparing every combination of explanatory variables in a Bayesian spatial framework remains unfeasible for most researchers. The aim of this study was to develop a malaria risk map using a systematic and practicable variable selection process for spatial analysis and mapping of historical malaria risk in Botswana. Results Of 50 potential explanatory variables from eight environmental data themes, 42 were significantly associated with malaria prevalence in univariate logistic regression and were ranked by the Akaike Information Criterion. Those correlated with higher-ranking relatives of the same environmental theme, were temporarily excluded. The remaining 14 candidates were ranked by selection frequency after running automated step-wise selection procedures on 1000 bootstrap samples drawn from the data. A non-spatial multiple-variable model was developed through step-wise inclusion in order of selection frequency. Previously excluded variables were then re-evaluated for inclusion, using further step-wise bootstrap procedures, resulting in the exclusion of another variable. Finally a Bayesian geo-statistical model using Markov Chain Monte Carlo simulation was fitted to the data, resulting in a final model of three predictor variables, namely summer rainfall, mean annual temperature and altitude. Each was independently and significantly associated with malaria prevalence after allowing for spatial correlation. This model was used to predict malaria prevalence at unobserved locations, producing a smooth risk map for the whole country. Conclusion We have produced a highly plausible and parsimonious model of historical malaria risk for Botswana from point-referenced data from a 1961/2 prevalence survey of malaria infection in 1–14 year old children. After starting with a list of 50 potential variables we ended with three highly plausible predictors, by applying a systematic and repeatable staged variable selection procedure that included a spatial analysis, which has application for other environmentally determined infectious diseases. All this was accomplished using general-purpose statistical software. PMID:17892584

  10. Calibration of the ROSAT HRI Spectral Response

    NASA Technical Reports Server (NTRS)

    Prestwich, Andrea

    1998-01-01

    The ROSAT High Resolution Imager has a limited (2-band) spectral response. This spectral capability can give X-ray hardness ratios on spatial scales of 5 arcseconds. The spectral response of the center of the detector was calibrated before the launch of ROSAT, but the gain decreases-with time and also is a function of position on the detector. To complicate matters further, the satellite is "wobbled", possibly moving a source across several spatial gain states. These difficulties have prevented the spectral response of the ROSAT HRI from being used for scientific measurements. We have used Bright Earth data and in-flight calibration sources to map the spatial and temporal gain changes, and written software which will allow ROSAT users to generate a calibrated XSPEC response matrix and hence determine a calibrated hardness ratio. In this report, we describe the calibration procedure and show how to obtain a response matrix. In Section 2 we give an overview of the calibration procedure, in Section 3 we give a summary of HRI spatial and temporal gain variations. Section 4 describes the routines used to determine the gain distribution of a source. In Sections 5 and 6, we describe in detail how the Bright Earth database and calibration sources are used to derive a corrected response matrix for a given observation. Finally, Section 7 describes how to use the software.

  11. Calibration of the ROSAT HRI Spectral Response

    NASA Technical Reports Server (NTRS)

    Prestwich, Andrea H.; Silverman, John; McDowell, Jonathan; Callanan, Paul; Snowden, Steve

    2000-01-01

    The ROSAT High Resolution Imager has a limited (2-band) spectral response. This spectral capability can give X-ray hardness ratios on spatial scales of 5 arcseconds. The spectral response of the center of the detector was calibrated before the launch of ROSAT, but the gain decreases with time and also is a function of position on the detector. To complicate matters further, the satellite is 'wobbled', possibly moving a source across several spatial gain states. These difficulties have prevented the spectral response of the ROSAT High Resolution Imager (HRI) from being used for scientific measurements. We have used Bright Earth data and in-flight calibration sources to map the spatial and temporal gain changes, and written software which will allow ROSAT users to generate a calibrated XSPEC (an x ray spectral fitting package) response matrix and hence determine a calibrated hardness ratio. In this report, we describe the calibration procedure and show how to obtain a response matrix. In Section 2 we give an overview of the calibration procedure, in Section 3 we give a summary of HRI spatial and temporal gain variations. Section 4 describes the routines used to determine the gain distribution of a source. In Sections 5 and 6, we describe in detail how, the Bright Earth database and calibration sources are used to derive a corrected response matrix for a given observation. Finally, Section 7 describes how to use the software.

  12. Improving the Spatial Prediction of Soil Organic Carbon Stocks in a Complex Tropical Mountain Landscape by Methodological Specifications in Machine Learning Approaches

    PubMed Central

    Schmidt, Johannes; Glaser, Bruno

    2016-01-01

    Tropical forests are significant carbon sinks and their soils’ carbon storage potential is immense. However, little is known about the soil organic carbon (SOC) stocks of tropical mountain areas whose complex soil-landscape and difficult accessibility pose a challenge to spatial analysis. The choice of methodology for spatial prediction is of high importance to improve the expected poor model results in case of low predictor-response correlations. Four aspects were considered to improve model performance in predicting SOC stocks of the organic layer of a tropical mountain forest landscape: Different spatial predictor settings, predictor selection strategies, various machine learning algorithms and model tuning. Five machine learning algorithms: random forests, artificial neural networks, multivariate adaptive regression splines, boosted regression trees and support vector machines were trained and tuned to predict SOC stocks from predictors derived from a digital elevation model and satellite image. Topographical predictors were calculated with a GIS search radius of 45 to 615 m. Finally, three predictor selection strategies were applied to the total set of 236 predictors. All machine learning algorithms—including the model tuning and predictor selection—were compared via five repetitions of a tenfold cross-validation. The boosted regression tree algorithm resulted in the overall best model. SOC stocks ranged between 0.2 to 17.7 kg m-2, displaying a huge variability with diffuse insolation and curvatures of different scale guiding the spatial pattern. Predictor selection and model tuning improved the models’ predictive performance in all five machine learning algorithms. The rather low number of selected predictors favours forward compared to backward selection procedures. Choosing predictors due to their indiviual performance was vanquished by the two procedures which accounted for predictor interaction. PMID:27128736

  13. Cross-Sectional Transport Imaging in a Multijunction Solar Cell

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haegel, Nancy M.; Ke, Chi-Wen; Taha, Hesham

    2015-06-14

    Combining highly localized electron-beam excitation at a point with the spatial resolution capability of optical near-field imaging, we have imaged carrier transport in a cross-sectioned multijunction (GaInP/GaInAs/Ge) solar cell. We image energy transport associated with carrier diffusion throughout the full width of the middle (GaInAs) cell and luminescent coupling from point excitation in the top cell GaInP to the middle cell. Supporting cathodoluminescence and near-field photoluminescence measurements demonstrate excitation-dependent Fermi level splitting effects that influence cross-sectioned spectroscopy results as well as transport limitations on the spatial resolution of cross-sectional measurements.

  14. Spatiotemporal encoding of search strategies by prefrontal neurons.

    PubMed

    Chiang, Feng-Kuei; Wallis, Joni D

    2018-05-08

    Working memory is capacity-limited. In everyday life we rarely notice this limitation, in part because we develop behavioral strategies that help mitigate the capacity limitation. How behavioral strategies are mediated at the neural level is unclear, but a likely locus is lateral prefrontal cortex (LPFC). Neurons in LPFC play a prominent role in working memory and have been shown to encode behavioral strategies. To examine the role of LPFC in overcoming working-memory limitations, we recorded the activity of LPFC neurons in animals trained to perform a serial self-ordered search task. This task measured the ability to prospectively plan the selection of unchosen spatial search targets while retrospectively tracking which targets were previously visited. We found that individual LPFC neurons encoded the spatial location of the current search target but also encoded the spatial location of targets up to several steps away in the search sequence. Neurons were more likely to encode prospective than retrospective targets. When subjects used a behavioral strategy of stereotyped target selection, mitigating the working-memory requirements of the task, not only did the number of selection errors decrease but there was a significant reduction in the strength of spatial encoding in LFPC. These results show that LPFC neurons have spatiotemporal mnemonic fields, in that their firing rates are modulated both by the spatial location of future selection behaviors and the temporal organization of that behavior. Furthermore, the strength of this tuning can be dynamically modulated by the demands of the task.

  15. Spatial and temporal air quality pattern recognition using environmetric techniques: a case study in Malaysia.

    PubMed

    Syed Abdul Mutalib, Sharifah Norsukhairin; Juahir, Hafizan; Azid, Azman; Mohd Sharif, Sharifah; Latif, Mohd Talib; Aris, Ahmad Zaharin; Zain, Sharifuddin M; Dominick, Doreena

    2013-09-01

    The objective of this study is to identify spatial and temporal patterns in the air quality at three selected Malaysian air monitoring stations based on an eleven-year database (January 2000-December 2010). Four statistical methods, Discriminant Analysis (DA), Hierarchical Agglomerative Cluster Analysis (HACA), Principal Component Analysis (PCA) and Artificial Neural Networks (ANNs), were selected to analyze the datasets of five air quality parameters, namely: SO2, NO2, O3, CO and particulate matter with a diameter size of below 10 μm (PM10). The three selected air monitoring stations share the characteristic of being located in highly urbanized areas and are surrounded by a number of industries. The DA results show that spatial characterizations allow successful discrimination between the three stations, while HACA shows the temporal pattern from the monthly and yearly factor analysis which correlates with severe haze episodes that have happened in this country at certain periods of time. The PCA results show that the major source of air pollution is mostly due to the combustion of fossil fuel in motor vehicles and industrial activities. The spatial pattern recognition (S-ANN) results show a better prediction performance in discriminating between the regions, with an excellent percentage of correct classification compared to DA. This study presents the necessity and usefulness of environmetric techniques for the interpretation of large datasets aiming to obtain better information about air quality patterns based on spatial and temporal characterizations at the selected air monitoring stations.

  16. Masticophis flagellum selects florida scrub habitat at multiple spatial scales

    USGS Publications Warehouse

    Halstead, B.J.; Mushinsky, H.R.; McCoy, E.D.

    2009-01-01

    The use of space by individual animals strongly influences the spatial extent, abundance, and growth rates of their populations. We analyzed the spatial ecology and habitat selection of Masticophis flagellum (the coachwhip) at three different scales to determine which habitats are most important to this species. Home ranges and mean daily displacements of M. flagellum in Florida were large compared to individuals in other populations of this species. Home ranges contained a greater proportion of Florida scrub habitat than did the study site as a whole, and individuals selected Florida scrub habitat within their home ranges. For both selection of the home range within the study site and selection of habitats within the home range, mesic cutthroat and hydric swamp habitats were avoided. Standardized selection ratios of Florida scrub patches were positively correlated with lizard abundance. Several non-mutually exclusive mechanisms, including foraging success (prey abundance, prey vulnerability, and foraging efficiency), abundance of refugia, and thermoregulatory opportunity may underlie the selection of Florida scrub by M. flagellum. Historic rarity and anthropogenic loss and fragmentation of Florida scrub habitat, coupled with the long-distance movements, large home ranges, and selection of Florida scrub by M. flagellum, indicate that large contiguous tracts of land containing Florida scrub will be essential for the persistence of M. flagellum in central Florida. ?? 2009 by The Herpetologists' League, Inc.

  17. Dynamical symmetry enhancement near N = 2, D = 4 gauged supergravity horizons

    NASA Astrophysics Data System (ADS)

    Gutowski, J.; Mohaupt, T.; Papadopoulos, G.

    2017-03-01

    We show that all smooth Killing horizons with compact horizon sections of 4-dimensional gauged N = 2 supergravity coupled to any number of vector multiplets preserve 2{c}_1(K)+4ℓ supersymmetries, where K is a pull-back of the Hodge bundle of the special Kähler manifold on the horizon spatial section. We also demonstrate that all such horizons with {c}_1(K)=0 exhibit an sl(2,R) symmetry and preserve either 4 or 8 supersymmetries. If the orbits of the sl(2,R) symmetry are 2-dimensional, the horizons are warped products of AdS2 with the horizon spatial section. Otherwise, the horizon section admits an isometry which preserves all the fields. The proof of these results is centered on the use of index theorem in conjunction with an appropriate generalization of the Lichnerowicz theorem for horizons that preserve at least one supersymmetry. In all {c}_1(K)=0 cases, we specify the local geometry of spatial horizon sections and demonstrate that the solutions are determined by first order non-linear ordinary differential equations on some of the fields.

  18. Identifying public water facilities with low spatial variability of disinfection by-products for epidemiological investigations

    PubMed Central

    Hinckley, A; Bachand, A; Nuckols, J; Reif, J

    2005-01-01

    Background and Aims: Epidemiological studies of disinfection by-products (DBPs) and reproductive outcomes have been hampered by misclassification of exposure. In most epidemiological studies conducted to date, all persons living within the boundaries of a water distribution system have been assigned a common exposure value based on facility-wide averages of trihalomethane (THM) concentrations. Since THMs do not develop uniformly throughout a distribution system, assignment of facility-wide averages may be inappropriate. One approach to mitigate this potential for misclassification is to select communities for epidemiological investigations that are served by distribution systems with consistently low spatial variability of THMs. Methods and Results: A feasibility study was conducted to develop methods for community selection using the Information Collection Rule (ICR) database, assembled by the US Environmental Protection Agency. The ICR database contains quarterly DBP concentrations collected between 1997 and 1998 from the distribution systems of 198 public water facilities with minimum service populations of 100 000 persons. Facilities with low spatial variation of THMs were identified using two methods; 33 facilities were found with low spatial variability based on one or both methods. Because brominated THMs may be important predictors of risk for adverse reproductive outcomes, sites were categorised into three exposure profiles according to proportion of brominated THM species and average TTHM concentration. The correlation between THMs and haloacetic acids (HAAs) in these facilities was evaluated to see whether selection by total trihalomethanes (TTHMs) corresponds to low spatial variability for HAAs. TTHMs were only moderately correlated with HAAs (r = 0.623). Conclusions: Results provide a simple method for a priori selection of sites with low spatial variability from state or national public water facility datasets as a means to reduce exposure misclassification in epidemiological studies of DBPs. PMID:15961627

  19. Hydroecological monitoring in the headwaters of the Volga River

    NASA Astrophysics Data System (ADS)

    Kuzovlev, Viacheslav V.; Zhenikov, Yuri N.; Zhenikov, Kyrill Y.; Shaporenko, Sergey I.; Haun, Stefan; Füreder, Leopold; Schletterer, Martin

    2016-04-01

    Europe's largest river, the Volga (3551 km), has experienced multiple stressors from human activities (i.e. the Volga Basin comprises about 40 % of the Russian population, 45 % of the country's industry and more than 50 % of its agriculture). During the research expedition "Upper Volga 2005" an assessment of hydrological, limnochemical and biological parameters was carried out by scientists from the Russian Federation and from Austria. The extensive sampling in 2005 showed that the free-flowing section of the Volga River, located upstream of Tver, represents conditions which are either reference or least disturbed - thus it can be considered as a refugial system for freshwater biota of the European lowlands. Subsequently three stretches in the headwaters of the Volga River (Rzhev, Staritsa, Tver) were selected for the monitoring programme "REFCOND_VOLGA", which is in operation since 2006. These locations correspond also with the sampling sites of ROSHYDROMET, i.e. at Tver physic-chemical samples are taken monthly and at Rzhev samples are taken in the main hydrological periods. The laboratory ship "ROSHYDROMET 11" conducted monthly cruises between Tver and Kalyazin (Ivankovskoye and Uglichskoye reservoirs on Volga) in the headwaters during the navigation period (May - October). This also includes measurements with ADCP, which further allow the analyses of the spatial distribution of the suspended solids within cross sections. In addition sediment fluxes were derived by using the acoustic backscatter signal strength from the acoustic current Doppler profiler (ADCP). We exemplify at the monitoring sites the spatial distribution of different sediments, i.e. choriotope types, according the longitudinal profile of the river. We show that it is highly influenced by morphodynamics in the different river sections and this corresponds with the zoobenthos fauna accordingly. This interdisciplinary approach, including sediment conditions, limnochemistry, hydrology and hydrobiology, leads to a hydro-ecological reference for European lowland rivers.

  20. Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis.

    PubMed

    Stack, Edward C; Wang, Chichung; Roman, Kristin A; Hoyt, Clifford C

    2014-11-01

    Tissue sections offer the opportunity to understand a patient's condition, to make better prognostic evaluations and to select optimum treatments, as evidenced by the place pathology holds today in clinical practice. Yet, there is a wealth of information locked up in a tissue section that is only partially accessed, due mainly to the limitations of tools and methods. Often tissues are assessed primarily based on visual analysis of one or two proteins, or 2-3 DNA or RNA molecules. Even while analysis is still based on visual perception, image analysis is starting to address the variability of human perception. This is in contrast to measuring characteristics that are substantially out of reach of human perception, such as parameters revealed through co-expression, spatial relationships, heterogeneity, and low abundance molecules. What is not routinely accessed is the information revealed through simultaneous detection of multiple markers, the spatial relationships among cells and tissue in disease, and the heterogeneity now understood to be critical to developing effective therapeutic strategies. Our purpose here is to review and assess methods for multiplexed, quantitative, image analysis based approaches, using new multicolor immunohistochemistry methods, automated multispectral slide imaging, and advanced trainable pattern recognition software. A key aspect of our approach is presenting imagery in a workflow that engages the pathologist to utilize the strengths of human perception and judgment, while significantly expanding the range of metrics collectable from tissue sections and also provide a level of consistency and precision needed to support the complexities of personalized medicine. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  1. Estimating the spatial scales of landscape effects on abundance

    Treesearch

    Richard Chandler; Jeffrey Hepinstall-Cymerman

    2016-01-01

    Spatial variation in abundance is influenced by local- and landscape-level environmental variables, but modeling landscape effects is challenging because the spatial scales of the relationships are unknown. Current approaches involve buffering survey locations with polygons of various sizes and using model selection to identify the best scale. The buffering...

  2. Women Match Men when Learning a Spatial Skill

    ERIC Educational Resources Information Center

    Spence, Ian; Yu, Jingjie Jessica; Feng, Jing; Marshman, Jeff

    2009-01-01

    Meta-analytic studies have concluded that although training improves spatial cognition in both sexes, the male advantage generally persists. However, because some studies run counter to this pattern, a closer examination of the anomaly is warranted. The authors investigated the acquisition of a basic skill (spatial selective attention) using a…

  3. A spatial-temporal system for dynamic cadastral management.

    PubMed

    Nan, Liu; Renyi, Liu; Guangliang, Zhu; Jiong, Xie

    2006-03-01

    A practical spatio-temporal database (STDB) technique for dynamic urban land management is presented. One of the STDB models, the expanded model of Base State with Amendments (BSA), is selected as the basis for developing the dynamic cadastral management technique. Two approaches, the Section Fast Indexing (SFI) and the Storage Factors of Variable Granularity (SFVG), are used to improve the efficiency of the BSA model. Both spatial graphic data and attribute data, through a succinct engine, are stored in standard relational database management systems (RDBMS) for the actual implementation of the BSA model. The spatio-temporal database is divided into three interdependent sub-databases: present DB, history DB and the procedures-tracing DB. The efficiency of database operation is improved by the database connection in the bottom layer of the Microsoft SQL Server. The spatio-temporal system can be provided at a low-cost while satisfying the basic needs of urban land management in China. The approaches presented in this paper may also be of significance to countries where land patterns change frequently or to agencies where financial resources are limited.

  4. A model for the selective amplification of spatially coherent waves in a centrifugal compressor on the verge of rotating stall

    NASA Technical Reports Server (NTRS)

    Lawless, Patrick B.; Fleeter, Sanford

    1993-01-01

    A simple model for the stability zones of a low speed centrifugal compressor is developed, with the goal of understanding the driving mechanism for the changes in stalling behavior predicted for, and observed in, the Purdue Low Speed Centrifugal Research Compressor Facility. To this end, earlier analyses of rotating stall suppression in centrifugal compressors are presented in a reduced form that preserves the essential parameters of the model that affect the stalling behavior of the compressor. The model is then used to illuminate the relationship between compressor geometry, expected mode shape, and regions of amplification for weak waves which are indicative of the susceptibility of the system to rotating stall. The results demonstrate that increasing the stagger angle of the diffuser vanes, and consequently the diffusion path length, results in the compressor moving towards a condition where higher-order spatial modes are excited during stall initiation. Similarly, flow acceleration in the diffuser section caused by an increase in the number of diffuser vanes also results in the excitation of higher modes.

  5. Cosmological models with homogeneous and isotropic spatial sections

    NASA Astrophysics Data System (ADS)

    Katanaev, M. O.

    2017-05-01

    The assumption that the universe is homogeneous and isotropic is the basis for the majority of modern cosmological models. We give an example of a metric all of whose spatial sections are spaces of constant curvature but the space-time is nevertheless not homogeneous and isotropic as a whole. We give an equivalent definition of a homogeneous and isotropic universe in terms of embedded manifolds.

  6. Contralateral Bias of High Spatial Frequency Tuning and Cardinal Direction Selectivity in Mouse Visual Cortex

    PubMed Central

    Zeitoun, Jack H.; Kim, Hyungtae

    2017-01-01

    Binocular mechanisms for visual processing are thought to enhance spatial acuity by combining matched input from the two eyes. Studies in the primary visual cortex of carnivores and primates have confirmed that eye-specific neuronal response properties are largely matched. In recent years, the mouse has emerged as a prominent model for binocular visual processing, yet little is known about the spatial frequency tuning of binocular responses in mouse visual cortex. Using calcium imaging in awake mice of both sexes, we show that the spatial frequency preference of cortical responses to the contralateral eye is ∼35% higher than responses to the ipsilateral eye. Furthermore, we find that neurons in binocular visual cortex that respond only to the contralateral eye are tuned to higher spatial frequencies. Binocular neurons that are well matched in spatial frequency preference are also matched in orientation preference. In contrast, we observe that binocularly mismatched cells are more mismatched in orientation tuning. Furthermore, we find that contralateral responses are more direction-selective than ipsilateral responses and are strongly biased to the cardinal directions. The contralateral bias of high spatial frequency tuning was found in both awake and anesthetized recordings. The distinct properties of contralateral cortical responses may reflect the functional segregation of direction-selective, high spatial frequency-preferring neurons in earlier stages of the central visual pathway. Moreover, these results suggest that the development of binocularity and visual acuity may engage distinct circuits in the mouse visual system. SIGNIFICANCE STATEMENT Seeing through two eyes is thought to improve visual acuity by enhancing sensitivity to fine edges. Using calcium imaging of cellular responses in awake mice, we find surprising asymmetries in the spatial processing of eye-specific visual input in binocular primary visual cortex. The contralateral visual pathway is tuned to higher spatial frequencies than the ipsilateral pathway. At the highest spatial frequencies, the contralateral pathway strongly prefers to respond to visual stimuli along the cardinal (horizontal and vertical) axes. These results suggest that monocular, and not binocular, mechanisms set the limit of spatial acuity in mice. Furthermore, they suggest that the development of visual acuity and binocularity in mice involves different circuits. PMID:28924011

  7. Population Coding of Visual Space: Comparison of Spatial Representations in Dorsal and Ventral Pathways

    PubMed Central

    Sereno, Anne B.; Lehky, Sidney R.

    2011-01-01

    Although the representation of space is as fundamental to visual processing as the representation of shape, it has received relatively little attention from neurophysiological investigations. In this study we characterize representations of space within visual cortex, and examine how they differ in a first direct comparison between dorsal and ventral subdivisions of the visual pathways. Neural activities were recorded in anterior inferotemporal cortex (AIT) and lateral intraparietal cortex (LIP) of awake behaving monkeys, structures associated with the ventral and dorsal visual pathways respectively, as a stimulus was presented at different locations within the visual field. In spatially selective cells, we find greater modulation of cell responses in LIP with changes in stimulus position. Further, using a novel population-based statistical approach (namely, multidimensional scaling), we recover the spatial map implicit within activities of neural populations, allowing us to quantitatively compare the geometry of neural space with physical space. We show that a population of spatially selective LIP neurons, despite having large receptive fields, is able to almost perfectly reconstruct stimulus locations within a low-dimensional representation. In contrast, a population of AIT neurons, despite each cell being spatially selective, provide less accurate low-dimensional reconstructions of stimulus locations. They produce instead only a topologically (categorically) correct rendition of space, which nevertheless might be critical for object and scene recognition. Furthermore, we found that the spatial representation recovered from population activity shows greater translation invariance in LIP than in AIT. We suggest that LIP spatial representations may be dimensionally isomorphic with 3D physical space, while in AIT spatial representations may reflect a more categorical representation of space (e.g., “next to” or “above”). PMID:21344010

  8. Layerwise Monitoring of the Selective Laser Melting Process by Thermography

    NASA Astrophysics Data System (ADS)

    Krauss, Harald; Zeugner, Thomas; Zaeh, Michael F.

    Selective Laser Melting is utilized to build parts directly from CAD data. In this study layerwise monitoring of the temperature distribution is used to gather information about the process stability and the resulting part quality. The heat distribution varies with different kinds of parameters including scan vector length, laser power, layer thickness and inter-part distance in the job layout. By integration of an off-axis mounted uncooled thermal detector, the solidification as well as the layer deposition are monitored and evaluated. This enables the identification of hot spots in an early stage during the solidification process and helps to avoid process interrupts. Potential quality indicators are derived from spatially resolved measurement data and are correlated to the resulting part properties. A model of heat dissipation is presented based on the measurement of the material response for varying heat input. Current results show the feasibility of process surveillance by thermography for a limited section of the building platform in a commercial system.

  9. Ecological and evolutionary consequences of tri-trophic interactions: Spatial variation and effects of plant density.

    PubMed

    Abdala-Roberts, Luis; Parra-Tabla, Víctor; Moreira, Xoaquín; Ramos-Zapata, José

    2017-02-01

    The factors driving variation in species interactions are often unknown, and few studies have made a link between changes in interactions and the strength of selection. We report on spatial variation in functional responses by a seed predator (SP) and its parasitic wasps associated with the herb Ruellia nudiflora . We assessed the influence of plant density on consumer responses and determined whether density effects and spatial variation in functional responses altered natural selection by these consumers on the plant. We established common gardens at two sites in Yucatan, Mexico, and planted R. nudiflora at two densities in each garden. We recorded fruit output and SP and parasitoid attack; calculated relative fitness (seed number) under scenarios of three trophic levels (accounting for SP and parasitoid effects), two trophic levels (accounting for SP but not parasitoid effects), and one trophic level (no consumer effects); and compared selection strength on fruit number under these scenarios across sites and densities. There was spatial variation in SP recruitment, whereby the SP functional response was negatively density-dependent at one site but density-independent at the other; parasitoid responses were density-independent and invariant across sites. Site variation in SP attack led, in turn, to differences in SP selection on fruit output, and parasitoids did not alter SP selection. There were no significant effects of density at either site. Our results provide a link between consumer functional responses and consumer selection on plants, which deepens our understanding of geographic variation in the evolutionary outcomes of multitrophic interactions. © 2017 Botanical Society of America.

  10. Optically-sectioned two-shot structured illumination microscopy with Hilbert-Huang processing.

    PubMed

    Patorski, Krzysztof; Trusiak, Maciej; Tkaczyk, Tomasz

    2014-04-21

    We introduce a fast, simple, adaptive and experimentally robust method for reconstructing background-rejected optically-sectioned images using two-shot structured illumination microscopy. Our innovative data demodulation method needs two grid-illumination images mutually phase shifted by π (half a grid period) but precise phase displacement between two frames is not required. Upon frames subtraction the input pattern with increased grid modulation is obtained. The first demodulation stage comprises two-dimensional data processing based on the empirical mode decomposition for the object spatial frequency selection (noise reduction and bias term removal). The second stage consists in calculating high contrast image using the two-dimensional spiral Hilbert transform. Our algorithm effectiveness is compared with the results calculated for the same input data using structured-illumination (SIM) and HiLo microscopy methods. The input data were collected for studying highly scattering tissue samples in reflectance mode. Results of our approach compare very favorably with SIM and HiLo techniques.

  11. Practical guidance on characterizing availability in resource selection functions under a use-availability design

    USGS Publications Warehouse

    Northrup, Joseph M.; Hooten, Mevin B.; Anderson, Charles R.; Wittemyer, George

    2013-01-01

    Habitat selection is a fundamental aspect of animal ecology, the understanding of which is critical to management and conservation. Global positioning system data from animals allow fine-scale assessments of habitat selection and typically are analyzed in a use-availability framework, whereby animal locations are contrasted with random locations (the availability sample). Although most use-availability methods are in fact spatial point process models, they often are fit using logistic regression. This framework offers numerous methodological challenges, for which the literature provides little guidance. Specifically, the size and spatial extent of the availability sample influences coefficient estimates potentially causing interpretational bias. We examined the influence of availability on statistical inference through simulations and analysis of serially correlated mule deer GPS data. Bias in estimates arose from incorrectly assessing and sampling the spatial extent of availability. Spatial autocorrelation in covariates, which is common for landscape characteristics, exacerbated the error in availability sampling leading to increased bias. These results have strong implications for habitat selection analyses using GPS data, which are increasingly prevalent in the literature. We recommend researchers assess the sensitivity of their results to their availability sample and, where bias is likely, take care with interpretations and use cross validation to assess robustness.

  12. Cross-sectional transport imaging in a multijunction solar cell

    DOE PAGES

    Haegel, Nancy M.; Ke, Chi -Wen; Taha, Hesham; ...

    2016-12-01

    Here, we combine a highly localized electron-beam point source excitation to generate excess free carriers with the spatial resolution of optical near-field imaging to map recombination in a cross-sectioned multijunction (Ga 0.5In 0.5P/GaIn 0.01As/Ge) solar cell. By mapping the spatial variations in emission of light for fixed generation (as opposed to traditional cathodoluminescence (CL), which maps integrated emission as a function of position of generation), it is possible to directly monitor the motion of carriers and photons. We observe carrier diffusion throughout the full width of the middle (GaInAs) cell, as well as luminescent coupling from point source excitation inmore » the top cell GaInP to the middle cell. Supporting CL and near-field photoluminescence (PL) measurements demonstrate the excitation-dependent Fermi level splitting effects that influence cross-sectioned spectroscopy results, as well as transport limitations on the spatial resolution of conventional cross-sectional far-field measurements.« less

  13. Spatial heterogeneity and scale-dependent habitat selection for two sympatric raptors in mixed-grass prairie.

    PubMed

    Atuo, Fidelis Akunke; O'Connell, Timothy John

    2017-08-01

    Sympatric predators are predicted to partition resources, especially under conditions of food limitation. Spatial heterogeneity that influences prey availability might play an important role in the scales at which potential competitors select habitat. We assessed potential mechanisms for coexistence by examining the role of heterogeneity in resource partitioning between sympatric raptors overwintering in the southern Great Plains. We conducted surveys for wintering Red-tailed hawk ( Buteo jamaicensis ) and Northern Harrier ( Circus cyanea ) at two state wildlife management areas in Oklahoma, USA. We used information from repeated distance sampling to project use locations in a GIS. We applied resource selection functions to model habitat selection at three scales and analyzed for niche partitioning using the outlying mean index. Habitat selection of the two predators was mediated by spatial heterogeneity. The two predators demonstrated significant fine-scale discrimination in habitat selection in homogeneous landscapes, but were more sympatric in heterogeneous landscapes. Red-tailed hawk used a variety of cover types in heterogeneous landscapes but specialized on riparian forest in homogeneous landscapes. Northern Harrier specialized on upland grasslands in homogeneous landscapes but selected more cover types in heterogeneous landscapes. Our study supports the growing body of evidence that landscapes can affect animal behaviors. In the system we studied, larger patches of primary land cover types were associated with greater allopatry in habitat selection between two potentially competing predators. Heterogeneity within the scale of raptor home ranges was associated with greater sympatry in use and less specialization in land cover types selected.

  14. Joint modelling of potentially avoidable hospitalisation for five diseases accounting for spatiotemporal effects: A case study in New South Wales, Australia.

    PubMed

    Baker, Jannah; White, Nicole; Mengersen, Kerrie; Rolfe, Margaret; Morgan, Geoffrey G

    2017-01-01

    Three variant formulations of a spatiotemporal shared component model are proposed that allow examination of changes in shared underlying factors over time. Models are evaluated within the context of a case study examining hospitalisation rates for five chronic diseases for residents of a regional area in New South Wales: type II diabetes mellitus (DMII), chronic obstructive pulmonary disease (COPD), coronary arterial disease (CAD), hypertension (HT) and congestive heart failure (CHF) between 2001-2006. These represent ambulatory care sensitive (ACS) conditions, often used as a proxy for avoidable hospitalisations. Using a selected model, the effects of socio-economic status (SES) as a shared component are estimated and temporal patterns in the influence of the residual shared spatial component are examined. Choice of model depends upon the application. In the featured application, a model allowing for changing influence of the shared spatial component over time was found to have the best fit and was selected for further analyses. Hospitalisation rates were found to be increasing for COPD and DMII, decreasing for CHF and stable for CAD and HT. SES was substantively associated with hospitalisation rates, with differing degrees of influence for each disease. In general, most of the spatial variation in hospitalisation rates was explained by disease-specific spatial components, followed by the residual shared spatial component. Appropriate selection of a joint disease model allows for the examination of temporal patterns of disease outcomes and shared underlying spatial factors, and distinction between different shared spatial factors.

  15. a Band Selection Method for High Precision Registration of Hyperspectral Image

    NASA Astrophysics Data System (ADS)

    Yang, H.; Li, X.

    2018-04-01

    During the registration of hyperspectral images and high spatial resolution images, too much bands in a hyperspectral image make it difficult to select bands with good registration performance. Terrible bands are possible to reduce matching speed and accuracy. To solve this problem, an algorithm based on Cram'er-Rao lower bound theory is proposed to select good matching bands in this paper. The algorithm applies the Cram'er-Rao lower bound theory to the study of registration accuracy, and selects good matching bands by CRLB parameters. Experiments show that the algorithm in this paper can choose good matching bands and provide better data for the registration of hyperspectral image and high spatial resolution image.

  16. Controlling modal interactions in lasers for frequency selection and power enhancement

    NASA Astrophysics Data System (ADS)

    Ge, Li

    2015-03-01

    The laser is an out-of-equilibrium non-linear wave system where the interplay of the cavity geometry and non-linear wave interactions determines the self-organized oscillation frequencies and the associated spatial field patterns. Using the correspondence between nonlinear and linear systems, we propose a simple and systematic method to achieve selective excitation of lasing modes that would have been dwarfed by more dominant ones. The key idea is incorporating the control of modal interaction into the spatial pump profile. Our proposal is most valuable in the regime of spatially and spectrally overlapping modes, which can lead to a significant enhancement of laser power as well.

  17. Using a filtering task to measure the spatial extent of selective attention

    PubMed Central

    Palmer, John; Moore, Cathleen M.

    2009-01-01

    The spatial extent of attention was investigated by measuring sensitivity to stimuli at to-be-ignored locations. Observers detected a stimulus at a cued location (target), while ignoring otherwise identical stimuli at nearby locations (foils). Only an attentional cue distinguished target from foil. Several experiments varied the contrast and separation of targets and foils. Two theories of selection were compared: contrast gain and a version of attention switching called an all-or-none mixture model. Results included large effects of separation, rejection of the contrast gain model, and the measurement of the size and profile of the spatial extent of attention. PMID:18405935

  18. The effect of spatial organization of targets and distractors on the capacity to selectively memorize objects in visual short-term memory.

    PubMed

    Abbes, Aymen Ben; Gavault, Emmanuelle; Ripoll, Thierry

    2014-01-01

    We conducted a series of experiments to explore how the spatial configuration of objects influences the selection and the processing of these objects in a visual short-term memory task. We designed a new experiment in which participants had to memorize 4 targets presented among 4 distractors. Targets were cued during the presentation of distractor objects. Their locations varied according to 4 spatial configurations. From the first to the last configuration, the distance between targets' locations was progressively increased. The results revealed a high capacity to select and memorize targets embedded among distractors even when targets were extremely distant from each other. This capacity is discussed in relation to the unitary conception of attention, models of split attention, and the competitive interaction model. Finally, we propose that the spatial dispersion of objects has different effects on attentional allocation and processing stages. Thus, when targets are extremely distant from each other, attentional allocation becomes more difficult while processing becomes easier. This finding implicates that these 2 aspects of attention need to be more clearly distinguished in future research.

  19. School-based surveys of malaria in Oromia Regional State, Ethiopia: a rapid survey method for malaria in low transmission settings

    PubMed Central

    2011-01-01

    Background In Ethiopia, malaria transmission is seasonal and unstable, with both Plasmodium falciparum and Plasmodium vivax endemic. Such spatial and temporal clustering of malaria only serves to underscore the importance of regularly collecting up-to-date malaria surveillance data to inform decision-making in malaria control. Cross-sectional school-based malaria surveys were conducted across Oromia Regional State to generate up-to-date data for planning malaria control interventions, as well as monitoring and evaluation of operational programme implementation. Methods Two hundred primary schools were randomly selected using a stratified and weighted sampling frame; 100 children aged five to 18 years were then randomly chosen within each school. Surveys were carried out in May 2009 and from October to December 2009, to coincide with the peak of malaria transmission in different parts of Oromia. Each child was tested for malaria by expert microscopy, their haemoglobin measured and a simple questionnaire completed. Satellite-derived environmental data were used to assess ecological correlates of Plasmodium infection; Bayesian geostatistical methods and Kulldorff's spatial scan statistic were employed to investigate spatial heterogeneity. Results A total 20,899 children from 197 schools provided blood samples, two selected schools were inaccessible and one school refused to participate. The overall prevalence of Plasmodium infection was found to be 0.56% (95% CI: 0.46-0.67%), with 53% of infections due to P. falciparum and 47% due to P. vivax. Of children surveyed, 17.6% (95% CI: 17.0-18.1%) were anaemic, while 46% reported sleeping under a mosquito net the previous night. Malaria was found at 30 (15%) schools to a maximum elevation of 2,187 metres, with school-level Plasmodium prevalence ranging between 0% and 14.5%. Although environmental variables were only weakly associated with P. falciparum and P. vivax infection, clusters of infection were identified within Oromia. Conclusion These findings demonstrate the marked spatial heterogeneity of malaria in Oromia and, in general, Ethiopia, and provide a strong epidemiological basis for planning as well as monitoring and evaluating malaria control in a setting with seasonal and unstable malaria transmission. PMID:21288368

  20. Additive effects of emotional content and spatial selective attention on electrocortical facilitation.

    PubMed

    Keil, Andreas; Moratti, Stephan; Sabatinelli, Dean; Bradley, Margaret M; Lang, Peter J

    2005-08-01

    Affectively arousing visual stimuli have been suggested to automatically attract attentional resources in order to optimize sensory processing. The present study crosses the factors of spatial selective attention and affective content, and examines the relationship between instructed (spatial) and automatic attention to affective stimuli. In addition to response times and error rate, electroencephalographic data from 129 electrodes were recorded during a covert spatial attention task. This task required silent counting of random-dot targets embedded in a 10 Hz flicker of colored pictures presented to both hemifields. Steady-state visual evoked potentials (ssVEPs) were obtained to determine amplitude and phase of electrocortical responses to pictures. An increase of ssVEP amplitude was observed as an additive function of spatial attention and emotional content. Statistical parametric mapping of this effect indicated occipito-temporal and parietal cortex activation contralateral to the attended visual hemifield in ssVEP amplitude modulation. This difference was most pronounced during selection of the left visual hemifield, at right temporal electrodes. In line with this finding, phase information revealed accelerated processing of aversive arousing, compared to affectively neutral pictures. The data suggest that affective stimulus properties modulate the spatiotemporal process along the ventral stream, encompassing amplitude amplification and timing changes of posterior and temporal cortex.

  1. Assessing comorbidity and correlates of wasting and stunting among children in Somalia using cross-sectional household surveys: 2007 to 2010

    PubMed Central

    Kinyoki, Damaris K; Kandala, Ngianga-Bakwin; Manda, Samuel O; Krainski, Elias T; Fuglstad, Geir-Arne; Moloney, Grainne M; Berkley, James A; Noor, Abdisalan M

    2016-01-01

    Objective Wasting and stunting may occur together at the individual child level; however, their shared geographic distribution and correlates remain unexplored. Understanding shared and separate correlates may inform interventions. We aimed to assess the spatial codistribution of wasting, stunting and underweight and investigate their shared correlates among children aged 6–59 months in Somalia. Setting Cross-sectional nutritional assessments surveys were conducted using structured interviews among communities in Somalia biannually from 2007 to 2010. A two-stage cluster sampling methodology was used to select children aged 6–59 months from households across three livelihood zones (pastoral, agropastoral and riverine). Using these data and environmental covariates, we implemented a multivariate spatial technique to estimate the codistribution and divergence of the risks and correlates of wasting and stunting at the 1×1 km spatial resolution. Participants 73 778 children aged 6–59 months from 1066 survey clusters in Somalia. Results Observed pairwise child level empirical correlations were 0.30, 0.70 and 0.73 between weight-for-height and height-for-age; height-for-age and weight-for-age, and weight-for-height and weight-for-age, respectively. Access to foods with high protein content and vegetation cover, a proxy of rainfall or drought, were associated with lower risk of wasting and stunting. Age, gender, illness, access to carbohydrates and temperature were correlates of all three indicators. The spatial codistribution was highest between stunting and underweight with relative risk values ranging between 0.15 and 6.20, followed by wasting and underweight (range: 0.18–5.18) and lowest between wasting and stunting (range: 0.26–4.32). Conclusions The determinants of wasting and stunting are largely shared, but their correlation is relatively variable in space. Significant hotspots of different forms of malnutrition occurred in the South Central regions of the country. Although nutrition response in Somalia has traditionally focused on wasting rather than stunting, integrated programming and interventions can effectively target both conditions to alleviate common risk factors. PMID:26962034

  2. Assessing comorbidity and correlates of wasting and stunting among children in Somalia using cross-sectional household surveys: 2007 to 2010.

    PubMed

    Kinyoki, Damaris K; Kandala, Ngianga-Bakwin; Manda, Samuel O; Krainski, Elias T; Fuglstad, Geir-Arne; Moloney, Grainne M; Berkley, James A; Noor, Abdisalan M

    2016-03-09

    Wasting and stunting may occur together at the individual child level; however, their shared geographic distribution and correlates remain unexplored. Understanding shared and separate correlates may inform interventions. We aimed to assess the spatial codistribution of wasting, stunting and underweight and investigate their shared correlates among children aged 6-59 months in Somalia. Cross-sectional nutritional assessments surveys were conducted using structured interviews among communities in Somalia biannually from 2007 to 2010. A two-stage cluster sampling methodology was used to select children aged 6-59 months from households across three livelihood zones (pastoral, agropastoral and riverine). Using these data and environmental covariates, we implemented a multivariate spatial technique to estimate the codistribution and divergence of the risks and correlates of wasting and stunting at the 1 × 1 km spatial resolution. 73,778 children aged 6-59 months from 1066 survey clusters in Somalia. Observed pairwise child level empirical correlations were 0.30, 0.70 and 0.73 between weight-for-height and height-for-age; height-for-age and weight-for-age, and weight-for-height and weight-for-age, respectively. Access to foods with high protein content and vegetation cover, a proxy of rainfall or drought, were associated with lower risk of wasting and stunting. Age, gender, illness, access to carbohydrates and temperature were correlates of all three indicators. The spatial codistribution was highest between stunting and underweight with relative risk values ranging between 0.15 and 6.20, followed by wasting and underweight (range: 0.18-5.18) and lowest between wasting and stunting (range: 0.26-4.32). The determinants of wasting and stunting are largely shared, but their correlation is relatively variable in space. Significant hotspots of different forms of malnutrition occurred in the South Central regions of the country. Although nutrition response in Somalia has traditionally focused on wasting rather than stunting, integrated programming and interventions can effectively target both conditions to alleviate common risk factors. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  3. Multiscale thermal refugia and stream habitat associations of chinook salmon in northwestern Oregon

    USGS Publications Warehouse

    Torgersen, Christian E.; Price, David M.; Li, Hiram W.; McIntosh, B.A.

    1999-01-01

    We quantified distribution and behavior of adult spring chinook salmon (Oncorhynchus tshawytscha) related to patterns of stream temperature and physical habitat at channel-unit, reach-, and section-level spatial scales in a wilderness stream and a disturbed stream in the John Day River basin in northeastern Oregon. We investigated the effectiveness of thermal remote sensing for analyzing spatial patterns of stream temperature and assessed habitat selection by spring chinook salmon, evaluating whether thermal refugia might be responsible for the persistence of these stocks in rivers where water temperatures frequently exceed their upper tolerance levels (25A?C) during spawning migration. By presenting stream temperature and the ecology of chinook salmon in a historical context, we could evaluate how changes in riverine habitat and thermal spatial structure, which can be caused by land-use practices, may influence distributional patterns of chinook salmon. Thermal remote sensing provided spatially continuous maps of stream temperature for reaches used by chinook salmon in the upper subbasins of the Middle Fork and North Fork John Day River. Electivity analysis and logistic regression were used to test for associations between the longitudinal distribution of salmon and cool-water areas and stream habitat characteristics. Chinook salmon were distributed nonuniformly in reaches throughout each stream. Salmon distribution and cool water temperature patterns were most strongly related at reach-level spatial scales in the warm stream, the Middle Fork (maximum likelihood ratio: P 0.30). Pools were preferred by adult chinook salmon in both subbasins (Bonferroni confidence interval: P a?? 0.05); however, riffles were used proportionately more frequently in the North Fork than in the Middle Fork. Our observations of thermal refugia and their use by chinook salmon at multiple spatial scales reveal that, although heterogeneity in the longitudinal stream temperature profile may be viewed as an ecological warning sign, thermal patchiness in streams also should be recognized for its biological potential to provide habitat for species existing at the margin of their environmental tolerances.

  4. Object Orientation Affects Spatial Language Comprehension

    ERIC Educational Resources Information Center

    Burigo, Michele; Sacchi, Simona

    2013-01-01

    Typical spatial descriptions, such as "The car is in front of the house," describe the position of a located object (LO; e.g., the car) in space relative to a reference object (RO) whose location is known (e.g., the house). The orientation of the RO affects spatial language comprehension via the reference frame selection process.…

  5. The Spatial Distribution of Attention within and across Objects

    ERIC Educational Resources Information Center

    Hollingworth, Andrew; Maxcey-Richard, Ashleigh M.; Vecera, Shaun P.

    2012-01-01

    Attention operates to select both spatial locations and perceptual objects. However, the specific mechanism by which attention is oriented to objects is not well understood. We examined the means by which object structure constrains the distribution of spatial attention (i.e., a "grouped array"). Using a modified version of the Egly et…

  6. Improving Genomic Prediction in Cassava Field Experiments Using Spatial Analysis.

    PubMed

    Elias, Ani A; Rabbi, Ismail; Kulakow, Peter; Jannink, Jean-Luc

    2018-01-04

    Cassava ( Manihot esculenta Crantz) is an important staple food in sub-Saharan Africa. Breeding experiments were conducted at the International Institute of Tropical Agriculture in cassava to select elite parents. Taking into account the heterogeneity in the field while evaluating these trials can increase the accuracy in estimation of breeding values. We used an exploratory approach using the parametric spatial kernels Power, Spherical, and Gaussian to determine the best kernel for a given scenario. The spatial kernel was fit simultaneously with a genomic kernel in a genomic selection model. Predictability of these models was tested through a 10-fold cross-validation method repeated five times. The best model was chosen as the one with the lowest prediction root mean squared error compared to that of the base model having no spatial kernel. Results from our real and simulated data studies indicated that predictability can be increased by accounting for spatial variation irrespective of the heritability of the trait. In real data scenarios we observed that the accuracy can be increased by a median value of 3.4%. Through simulations, we showed that a 21% increase in accuracy can be achieved. We also found that Range (row) directional spatial kernels, mostly Gaussian, explained the spatial variance in 71% of the scenarios when spatial correlation was significant. Copyright © 2018 Elias et al.

  7. Spatial Distribution of Bacterial Communities and Phenanthrene Degradation in the Rhizosphere of Lolium perenne L.

    PubMed Central

    Corgié, S. C.; Beguiristain, T.; Leyval, C.

    2004-01-01

    Rhizodegradation of organic pollutants, such as polycyclic aromatic hydrocarbons, is based on the effect of root-produced compounds, known as exudates. These exudates constitute an important and constant carbon source that selects microbial populations in the plant rhizosphere, modifying global as well as specific microbial activities. We conducted an experiment in two-compartment devices to show the selection of bacterial communities by root exudates and phenanthrene as a function of distance to roots. Using direct DNA extraction, PCR amplification, and thermal gradient gel electrophoresis screening, bacterial population profiles were analyzed in parallel to bacterial counts and quantification of phenanthrene biodegradation in three layers (0 to 3, 3 to 6, and 6 to 9 mm from root mat) of unplanted-polluted (phenanthrene), planted-polluted, and planted-unpolluted treatments. Bacterial community differed as a function of the distance to roots, in both the presence and the absence of phenanthrene. In the planted and polluted treatment, biodegradation rates showed a strong gradient with higher values near the roots. In the nonplanted treatment, bacterial communities were comparable in the three layers and phenanthrene biodegradation was high. Surprisingly, no biodegradation was detected in the section of planted polluted treatment farthest from the roots, where the bacterial community structure was similar to those of the nonplanted treatment. We conclude that root exudates and phenanthrene induce modifications of bacterial communities in polluted environments and spatially modify the activity of degrading bacteria. PMID:15184156

  8. Can Urbanization, Social and Spatial Disparities Help to Understand the Rise of Cardiometabolic Risk Factors in Bobo-Dioulasso? A Study in a Secondary City of Burkina Faso, West Africa

    PubMed Central

    Zeba, Augustin Nawidimbasba; Yaméogo, Marceline Téné; Tougouma, Somnoma Jean-Baptiste; Kassié, Daouda; Fournet, Florence

    2017-01-01

    Background: Unplanned urbanization plays a key role in chronic disease growth. This population-based cross-sectional study assessed the occurrence of cardiometabolic risk factors in Bobo-Dioulasso and their association with urbanization conditions. Methods: Through spatial sampling, four Bobo-Dioulasso sub-spaces were selected for a population survey to measure the adult health status. Yéguéré, Dogona, Tounouma and Secteur 25 had very different urbanization conditions (position within the city; time of creation and healthcare structure access). The sample size was estimated at 1000 households (250 for each sub-space) in which one adult (35 to 59-year-old) was randomly selected. Finally, 860 adults were surveyed. Anthropometric, socioeconomic and clinical data were collected. Arterial blood pressure was measured and blood samples were collected to assess glycemia. Results: Weight, body mass index and waist circumference (mean values) and serum glycemia (83.4 mg/dL ± 4.62 mmol/L) were significantly higher in Tounouma, Dogona, and Secteur 25 than in Yéguéré; the poorest and most rural-like sub-space (p = 0.001). Overall, 43.2%, 40.5%, 5.3% and 60.9% of participants had overweight, hypertension, hyperglycemia and one or more cardiometabolic risk markers, respectively. Conclusions: Bobo-Dioulasso is unprepared to face this public health issue and urgent responses are needed to reduce the health risks associated with unplanned urbanization. PMID:28375173

  9. Can Urbanization, Social and Spatial Disparities Help to Understand the Rise of Cardiometabolic Risk Factors in Bobo-Dioulasso? A Study in a Secondary City of Burkina Faso, West Africa.

    PubMed

    Zeba, Augustin Nawidimbasba; Yaméogo, Marceline Téné; Tougouma, Somnoma Jean-Baptiste; Kassié, Daouda; Fournet, Florence

    2017-04-04

    Background : Unplanned urbanization plays a key role in chronic disease growth. This population-based cross-sectional study assessed the occurrence of cardiometabolic risk factors in Bobo-Dioulasso and their association with urbanization conditions. Methods : Through spatial sampling, four Bobo-Dioulasso sub-spaces were selected for a population survey to measure the adult health status. Yéguéré, Dogona, Tounouma and Secteur 25 had very different urbanization conditions (position within the city; time of creation and healthcare structure access). The sample size was estimated at 1000 households (250 for each sub-space) in which one adult (35 to 59-year-old) was randomly selected. Finally, 860 adults were surveyed. Anthropometric, socioeconomic and clinical data were collected. Arterial blood pressure was measured and blood samples were collected to assess glycemia. Results : Weight, body mass index and waist circumference (mean values) and serum glycemia (83.4 mg/dL ± 4.62 mmol/L) were significantly higher in Tounouma, Dogona, and Secteur 25 than in Yéguéré; the poorest and most rural-like sub-space ( p = 0.001). Overall, 43.2%, 40.5%, 5.3% and 60.9% of participants had overweight, hypertension, hyperglycemia and one or more cardiometabolic risk markers, respectively. Conclusions : Bobo-Dioulasso is unprepared to face this public health issue and urgent responses are needed to reduce the health risks associated with unplanned urbanization.

  10. Quickbird Satellite in-orbit Modulation Transfer Function (MTF) Measurement Using Edge, Pulse and Impulse Methods for Summer 2003

    NASA Technical Reports Server (NTRS)

    Helder, Dennis; Choi, Taeyoung; Rangaswamy, Manjunath

    2005-01-01

    The spatial characteristics of an imaging system cannot be expressed by a single number or simple statement. However, the Modulation Transfer Function (MTF) is one approach to measure the spatial quality of an imaging system. Basically, MTF is the normalized spatial frequency response of an imaging system. The frequency response of the system can be evaluated by applying an impulse input. The resulting impulse response is termed the Point Spread function (PSF). This function is a measure of the amount of blurring present in the imaging system and is itself a useful measure of spatial quality. An underlying assumption is that the imaging system is linear and shift-independent. The Fourier transform of the PSF is called the Optical Transfer Function (OTF) and the normalized magnitude of the OTF is the MTF. In addition to using an impulse input, a knife-edge in technique has also been used in this project. The sharp edge exercises an imaging system at all spatial frequencies. The profile of an edge response from an imaging system is called an Edge Spread Function (ESF). Differentiation of the ESF results in a one-dimensional version of the Point Spread Function (PSF). Finally, MTF can be calculated through use of Fourier transform of the PSF as stated previously. Every image includes noise in some degree which makes MTF of PSF estimation more difficult. To avoid the noise effects, many MTF estimation approaches use smooth numerical models. Historically, Gaussian models and Fermi functions were applied to reduce the random noise in the output profiles. The pulse-input method was used to measure the MTF of the Landsat Thematic Mapper (TM) using 8th order even functions over the San Mateo Bridge in San Francisco, California. Because the bridge width was smaller than the 30-meter ground sample distance (GSD) of the TM, the Nyquist frequency was located before the first zero-crossing point of the sinc function from the Fourier transformation of the bridge pulse. To avoid the zero-crossing points in the frequency domain from a pulse, the pulse width should be less than the width of two pixels (or 2 GSD's), but the short extent of the pulse results in a poor signal-to-noise ratio. Similarly, for a high-resolution satellite imaging system such as Quickbird, the input pulse width was critical because of the zero crossing points and noise present in the background area. It is important, therefore, that the width of the input pulse be appropriately sized. Finally, the MTF was calculated by taking ratio between Fourier transform of output and Fourier transform of input. Regardless of whether the edge, pulse and impulse target method is used, the orientation of the targets is critical in order to obtain uniformly spaced sub-pixel data points. When the orientation is incorrect, sample data points tend to be located in clusters that result in poor reconstruction of the edge or pulse profiles. Thus, a compromise orientation must be selected so that all spectral bands can be accommodated. This report continues by outlining the objectives in Section 2, procedures followed in Section 3, descriptions of the field campaigns in Section 4, results in Section 5, and a brief summary in Section 6.

  11. Spatial Scaling of the Profile of Selective Attention in the Visual Field.

    PubMed

    Gannon, Matthew A; Knapp, Ashley A; Adams, Thomas G; Long, Stephanie M; Parks, Nathan A

    2016-01-01

    Neural mechanisms of selective attention must be capable of adapting to variation in the absolute size of an attended stimulus in the ever-changing visual environment. To date, little is known regarding how attentional selection interacts with fluctuations in the spatial expanse of an attended object. Here, we use event-related potentials (ERPs) to investigate the scaling of attentional enhancement and suppression across the visual field. We measured ERPs while participants performed a task at fixation that varied in its attentional demands (attentional load) and visual angle (1.0° or 2.5°). Observers were presented with a stream of task-relevant stimuli while foveal, parafoveal, and peripheral visual locations were probed by irrelevant distractor stimuli. We found two important effects in the N1 component of visual ERPs. First, N1 modulations to task-relevant stimuli indexed attentional selection of stimuli during the load task and further correlated with task performance. Second, with increased task size, attentional modulation of the N1 to distractor stimuli showed a differential pattern that was consistent with a scaling of attentional selection. Together, these results demonstrate that the size of an attended stimulus scales the profile of attentional selection across the visual field and provides insights into the attentional mechanisms associated with such spatial scaling.

  12. Cryptic sexual dimorphism in spatial memory and hippocampal oxytocin receptors in prairie voles (Microtus ochrogaster).

    PubMed

    Rice, Marissa A; Hobbs, Lauren E; Wallace, Kelly J; Ophir, Alexander G

    2017-09-01

    Sex differences are well documented and are conventionally associated with intense sex-specific selection. For example, spatial memory is frequently better in males, presumably due to males' tendency to navigate large spaces to find mates. Alternatively, monogamy (in which sex-specific selection is relatively relaxed) should diminish or eliminate differences in spatial ability and the mechanisms associated with this behavior. Nevertheless, phenotypic differences between monogamous males and females persist, sometimes cryptically. We hypothesize that sex-specific cognitive demands are present in monogamous species that will influence neural and behavioral phenotypes. The effects of these demands should be observable in spatial learning performance and neural structures associated with spatial learning and memory. We analyzed spatial memory performance, hippocampal volume and cell density, and hippocampal oxytocin receptor (OTR) expression in the socially monogamous prairie vole. Compared to females, males performed better in a spatial memory and spatial learning test. Although we found no sex difference in hippocampal volume or cell density, male OTR density was significantly lower than females, suggesting that performance may be regulated by sub-cellular mechanisms within the hippocampus that are less obvious than classic neuroanatomical features. Our results suggest an expanded role for oxytocin beyond facilitating social interactions, which may function in part to integrate social and spatial information. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Spatial Variation of Phosphorous Retention Capacity in Subsurface Flow Constructed Wetlands: Effect of Wetland Type and Inflow Loading

    PubMed Central

    Yu, Guangwei; Tan, Meijuan; Chong, Yunxiao; Long, Xinxian

    2015-01-01

    For verification of spatial distribution of phosphorous retention capacity in constructed wetlands systems(CWs), two horizontal subsurface flow(HSSF) CWs and two vertical subsurface flow(VSSF) CWs, using sand as substrate and Typha latifolia as wetland plants, were constructed and put into use for synthetic wastewater treatment. Five months later, significant spatial variations of TP and inorganic phosphorus(Ca-P, Fe-P and Al-P) were observed, which were found to be greatly affected by CWs type and hydraulic loading. The results revealed that though spatial distribution of Fe-P and Al-P displayed a similar order of substrate content as "rhizosphere" > "near-rhizosphere" > "non-rhizosphere" and "inflow section" > "outflow section" regardless of types and loading, the distribution of Ca-P was positively correlated to that of Fe-P and Al-P in HSSF CWs, while negative correlation was shown in VSSF CWs. As a result, TP spatial distribution in HSSF CWs demonstrated a greater dissimilarity than that in VSSF CWs. For HSSF CWs with low hydraulic loading, the lowest TP content was found in non-rhizosphere substrate of outflow section, while the highest one was discovered in rhizonsphere substrate of inflow section. The values in 6 parts of areas ranged from 0.138 g·kg-1 to 2.710 g·kg-1, which also were from -33.5% to 1209% compared to the control value. On contrast, spatial difference of TP content in substrates of VSSF CWs was insignificant, with a variation ranging from 0.776 g·kg-1 to 1.080 g·kg-1, that was 275% to 421% higher than the control value. In addition, when hydraulic loading was increased, TP content in VSSF CWs sharply decreased, ranging from 0.210 g·kg-1 to 0.634 g·kg-1. Meanwhile, dissimilarity of TP spatial distribution in HSSF CWs was reduced, with TP content ranging from 0.258 g·kg-1 to 2.237 g·kg-1. The results suggested that P spatial distribution should be taken into account for CWs design and operation. PMID:26218872

  14. Spatial Variation of Phosphorous Retention Capacity in Subsurface Flow Constructed Wetlands: Effect of Wetland Type and Inflow Loading.

    PubMed

    Yu, Guangwei; Tan, Meijuan; Chong, Yunxiao; Long, Xinxian

    2015-01-01

    For verification of spatial distribution of phosphorous retention capacity in constructed wetlands systems(CWs), two horizontal subsurface flow(HSSF) CWs and two vertical subsurface flow(VSSF) CWs, using sand as substrate and Typha latifolia as wetland plants, were constructed and put into use for synthetic wastewater treatment. Five months later, significant spatial variations of TP and inorganic phosphorus(Ca-P, Fe-P and Al-P) were observed, which were found to be greatly affected by CWs type and hydraulic loading. The results revealed that though spatial distribution of Fe-P and Al-P displayed a similar order of substrate content as "rhizosphere" > "near-rhizosphere" > "non-rhizosphere" and "inflow section" > "outflow section" regardless of types and loading, the distribution of Ca-P was positively correlated to that of Fe-P and Al-P in HSSF CWs, while negative correlation was shown in VSSF CWs. As a result, TP spatial distribution in HSSF CWs demonstrated a greater dissimilarity than that in VSSF CWs. For HSSF CWs with low hydraulic loading, the lowest TP content was found in non-rhizosphere substrate of outflow section, while the highest one was discovered in rhizonsphere substrate of inflow section. The values in 6 parts of areas ranged from 0.138 g·kg-1 to 2.710 g·kg-1, which also were from -33.5% to 1209% compared to the control value. On contrast, spatial difference of TP content in substrates of VSSF CWs was insignificant, with a variation ranging from 0.776 g·kg-1 to 1.080 g·kg-1, that was 275% to 421% higher than the control value. In addition, when hydraulic loading was increased, TP content in VSSF CWs sharply decreased, ranging from 0.210 g·kg-1 to 0.634 g·kg-1. Meanwhile, dissimilarity of TP spatial distribution in HSSF CWs was reduced, with TP content ranging from 0.258 g·kg-1 to 2.237 g·kg-1. The results suggested that P spatial distribution should be taken into account for CWs design and operation.

  15. Preferential selection based on degree difference in the spatial prisoner's dilemma games

    NASA Astrophysics Data System (ADS)

    Huang, Changwei; Dai, Qionglin; Cheng, Hongyan; Li, Haihong

    2017-10-01

    Strategy evolution in spatial evolutionary games is generally implemented through imitation processes between individuals. In most previous studies, it is assumed that individuals pick up one of their neighbors randomly to learn from. However, by considering the heterogeneity of individuals' influence in the real society, preferential selection is more realistic. Here, we introduce a preferential selection mechanism based on degree difference into spatial prisoner's dilemma games on Erdös-Rényi networks and Barabási-Albert scale-free networks and investigate the effects of the preferential selection on cooperation. The results show that, when the individuals prefer to choose the neighbors who have small degree difference with themselves to imitate, cooperation is hurt by the preferential selection. In contrast, when the individuals prefer to choose those large degree difference neighbors to learn from, there exists optimal preference strength resulting in the maximal cooperation level no matter what the network structure is. In addition, we investigate the robustness of the results against variations of the noise, the average degree and the size of network in the model, and find that the qualitative features of the results are unchanged.

  16. Fringe order correction for the absolute phase recovered by two selected spatial frequency fringe projections in fringe projection profilometry.

    PubMed

    Ding, Yi; Peng, Kai; Yu, Miao; Lu, Lei; Zhao, Kun

    2017-08-01

    The performance of the two selected spatial frequency phase unwrapping methods is limited by a phase error bound beyond which errors will occur in the fringe order leading to a significant error in the recovered absolute phase map. In this paper, we propose a method to detect and correct the wrong fringe orders. Two constraints are introduced during the fringe order determination of two selected spatial frequency phase unwrapping methods. A strategy to detect and correct the wrong fringe orders is also described. Compared with the existing methods, we do not need to estimate the threshold associated with absolute phase values to determine the fringe order error, thus making it more reliable and avoiding the procedure of search in detecting and correcting successive fringe order errors. The effectiveness of the proposed method is validated by the experimental results.

  17. Spatially selective assembly of quantum dot light emitters in an LED using engineered peptides.

    PubMed

    Demir, Hilmi Volkan; Seker, Urartu Ozgur Safak; Zengin, Gulis; Mutlugun, Evren; Sari, Emre; Tamerler, Candan; Sarikaya, Mehmet

    2011-04-26

    Semiconductor nanocrystal quantum dots are utilized in numerous applications in nano- and biotechnology. In device applications, where several different material components are involved, quantum dots typically need to be assembled at explicit locations for enhanced functionality. Conventional approaches cannot meet these requirements where assembly of nanocrystals is usually material-nonspecific, thereby limiting the control of their spatial distribution. Here we demonstrate directed self-assembly of quantum dot emitters at material-specific locations in a color-conversion LED containing several material components including a metal, a dielectric, and a semiconductor. We achieve a spatially selective immobilization of quantum dot emitters by using the unique material selectivity characteristics provided by the engineered solid-binding peptides as smart linkers. Peptide-decorated quantum dots exhibited several orders of magnitude higher photoluminescence compared to the control groups, thus, potentially opening up novel ways to advance these photonic platforms in applications ranging from chemical to biodetection.

  18. Methods for magnetic resonance analysis using magic angle technique

    DOEpatents

    Hu, Jian Zhi [Richland, WA; Wind, Robert A [Kennewick, WA; Minard, Kevin R [Kennewick, WA; Majors, Paul D [Kennewick, WA

    2011-11-22

    Methods of performing a magnetic resonance analysis of a biological object are disclosed that include placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 54.degree.44' relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. In particular embodiments the method includes pulsing the radio frequency to provide at least two of a spatially selective read pulse, a spatially selective phase pulse, and a spatially selective storage pulse. Further disclosed methods provide pulse sequences that provide extended imaging capabilities, such as chemical shift imaging or multiple-voxel data acquisition.

  19. Simultaneous weak measurement of angular and spatial Goos-Hänchen and Imbert-Fedorov shifts

    NASA Astrophysics Data System (ADS)

    Prajapati, Chandravati; Viswanathan, Nirmal K.

    2017-10-01

    We propose and demonstrate the weak measurement scheme to simultaneously measure the amplified angular and spatial contributions to the Goos-Hänchen (GH) and Imbert-Fedorov (IF) shifts, due to transmission through a glass plate. We have studied two cases of post-selection using a polarizer in the first case and a quarter-wave plate (QWP)-polarizer combination in the second case. The two cases are analyzed theoretically using Jones calculus of polarization formalism and the results are verified experimentally. In the first case of post-selection, the projection of the polarizer at +/- {{Δ }} away from the crossed position amplifies the angular GH and IF shifts, while in the second case of post-selection, the projection of QWP at +/- {{Δ }} and polarizer kept fixed measures the polarization ellipticity in the beam and thus amplifies the spatial shift along with the angular shift simultaneously, for {{Δ }}\\ll 1.

  20. The spatial resolution of silicon-based electron detectors in beta-autoradiography.

    PubMed

    Cabello, Jorge; Wells, Kevin

    2010-03-21

    Thin tissue autoradiography is an imaging modality where ex-vivo tissue sections are placed in direct contact with autoradiographic film. These tissue sections contain a radiolabelled ligand bound to a specific biomolecule under study. This radioligand emits beta - or beta+ particles ionizing silver halide crystals in the film. High spatial resolution autoradiograms are obtained using low energy radioisotopes, such as (3)H where an intrinsic 0.1-1 microm spatial resolution can be achieved. Several digital alternatives have been presented over the past few years to replace conventional film but their spatial resolution has yet to equal film, although silicon-based imaging technologies have demonstrated higher sensitivity compared to conventional film. It will be shown in this work how pixel size is a critical parameter for achieving high spatial resolution for low energy uncollimated beta imaging. In this work we also examine the confounding factors impeding silicon-based technologies with respect to spatial resolution. The study considers charge diffusion in silicon and detector noise, and this is applied to a range of radioisotopes typically used in autoradiography. Finally an optimal detector geometry to obtain the best possible spatial resolution for a specific technology and a specific radioisotope is suggested.

  1. Increasing the speed of tumour diagnosis during surgery with selective scanning Raman microscopy

    NASA Astrophysics Data System (ADS)

    Kong, Kenny; Rowlands, Christopher J.; Varma, Sandeep; Perkins, William; Leach, Iain H.; Koloydenko, Alexey A.; Pitiot, Alain; Williams, Hywel C.; Notingher, Ioan

    2014-09-01

    One of the main challenges in cancer surgery is ensuring that all tumour cells are removed during surgery, while sparing as much healthy tissue as possible. Histopathology, the gold-standard technique for cancer diagnosis, is often impractical for intra-operative use because of the time-consuming tissue preparation procedures (sectioning and staining). Raman micro-spectroscopy is a powerful technique that can discriminate between tumours and healthy tissues with high accuracy, based entirely on intrinsic chemical differences. However, raster-scanning Raman micro-spectroscopy is a slow imaging technique that typically requires data acquisition times as long as several days for typical tissue samples obtained during surgery (1 × 1 cm2) - in particular when high signal-to-noise ratio spectra are required to ensure accurate diagnosis. In this paper we present two techniques based on selective sampling Raman micro-spectroscopy that can overcome these limitations. In selective sampling, information regarding the spatial features of the tissue, either measured by an alternative optical technique or estimated in real-time from the Raman spectra, can be used to drastically reduce the number of Raman spectra required for diagnosis. These sampling strategies allowed diagnosis of basal cell carcinoma in skin tissue samples excised during Mohs micrographic surgery faster than frozen section histopathology, and two orders of magnitude faster than previous techniques based on raster-scanning Raman microscopy. Further development of these techniques may help during cancer surgery by providing a fast and objective way for surgeons to ensure the complete removal of tumour cells while sparing as much healthy tissue as possible.

  2. The role of spatial attention in visual word processing

    NASA Technical Reports Server (NTRS)

    Mccann, Robert S.; Folk, Charles L.; Johnston, James C.

    1992-01-01

    Subjects made lexical decisions on a target letter string presented above or below fixation. In Experiments 1 and 2, target location was cued 100 ms in advance of target onset. Responses were faster on validly than on invalidly cued trials. In Experiment 3, the target was sometimes accompanied by irrelevant stimuli on the other side of fixation; in such cases, responses were slowed (a spatial filtering effect). Both cuing and filtering effects on response time were additive with effects of word frequency and lexical status (words vs. nonwords). These findings are difficult to reconcile with claims that spatial attention is less involved in processing familiar words than in unfamiliar words and nonwords. The results can be reconciled with a late-selection locus of spatial attention only with difficulty, but are easily explained by early-selection models.

  3. Nanoantenna-Enhanced Infrared Spectroscopic Chemical Imaging.

    PubMed

    Kühner, Lucca; Hentschel, Mario; Zschieschang, Ute; Klauk, Hagen; Vogt, Jochen; Huck, Christian; Giessen, Harald; Neubrech, Frank

    2017-05-26

    Spectroscopic infrared chemical imaging is ideally suited for label-free and spatially resolved characterization of molecular species, but often suffers from low infrared absorption cross sections. Here, we overcome this limitation by utilizing confined electromagnetic near-fields of resonantly excited plasmonic nanoantennas, which enhance the molecular absorption by orders of magnitude. In the experiments, we evaporate microstructured chemical patterns of C 60 and pentacene with nanometer thickness on top of homogeneous arrays of tailored nanoantennas. Broadband mid-infrared spectra containing plasmonic and vibrational information were acquired with diffraction-limited resolution using a two-dimensional focal plane array detector. Evaluating the enhanced infrared absorption at the respective frequencies, spatially resolved chemical images were obtained. In these chemical images, the microstructured chemical patterns are only visible if nanoantennas are used. This confirms the superior performance of our approach over conventional spectroscopic infrared imaging. In addition to the improved sensitivity, our technique provides chemical selectivity, which would not be available with plasmonic imaging that is based on refractive index sensing. To extend the accessible spectral bandwidth of nanoantenna-enhanced spectroscopic imaging, we employed nanostructures with dual-band resonances, providing broadband plasmonic enhancement and sensitivity. Our results demonstrate the potential of nanoantenna-enhanced spectroscopic infrared chemical imaging for spatially resolved characterization of organic layers with thicknesses of several nanometers. This is of potential interest for medical applications which are currently hampered by state-of-art infrared techniques, e.g., for distinguishing cancerous from healthy tissues.

  4. Local T1-T2 distribution measurements in porous media

    NASA Astrophysics Data System (ADS)

    Vashaee, S.; Li, M.; Newling, B.; MacMillan, B.; Marica, F.; Kwak, H. T.; Gao, J.; Al-harbi, A. M.; Balcom, B. J.

    2018-02-01

    A novel slice-selective T1-T2 measurement is proposed to measure spatially resolved T1-T2 distributions. An adiabatic inversion pulse is employed for slice-selection. The slice-selective pulse is able to select a quasi-rectangular slice, on the order of 1 mm, at an arbitrary position within the sample. The method does not employ conventional selective excitation in which selective excitation is often accomplished by rotation of the longitudinal magnetization in the slice of interest into the transverse plane, but rather a subtraction based on CPMG data acquired with and without adiabatic inversion slice selection. T1 weighting is introduced during recovery from the inversion associated with slice selection. The local T1-T2 distributions measured are of similar quality to bulk T1-T2 measurements. The new method can be employed to characterize oil-water mixtures and other fluids in porous media. The method is beneficial when a coarse spatial distribution of the components is of interest.

  5. Attention Modifies Spatial Resolution According to Task Demands.

    PubMed

    Barbot, Antoine; Carrasco, Marisa

    2017-03-01

    How does visual attention affect spatial resolution? In texture-segmentation tasks, exogenous (involuntary) attention automatically increases resolution at the attended location, which improves performance where resolution is too low (at the periphery) but impairs performance where resolution is already too high (at central locations). Conversely, endogenous (voluntary) attention improves performance at all eccentricities, which suggests a more flexible mechanism. Here, using selective adaptation to spatial frequency, we investigated the mechanism by which endogenous attention benefits performance in resolution tasks. Participants detected a texture target that could appear at several eccentricities. Adapting to high or low spatial frequencies selectively affected performance in a manner consistent with changes in resolution. Moreover, adapting to high, but not low, frequencies mitigated the attentional benefit at central locations where resolution was too high; this shows that attention can improve performance by decreasing resolution. Altogether, our results indicate that endogenous attention benefits performance by modulating the contribution of high-frequency information in order to flexibly adjust spatial resolution according to task demands.

  6. Readout from iconic memory and selective spatial attention involve similar neural processes.

    PubMed

    Ruff, Christian C; Kristjánsson, Arni; Driver, Jon

    2007-10-01

    Iconic memory and spatial attention are often considered separately, but they may have functional similarities. Here we provide functional magnetic resonance imaging evidence for some common underlying neural effects. Subjects judged three visual stimuli in one hemifield of a bilateral array comprising six stimuli. The relevant hemifield for partial report was indicated by an auditory cue, administered either before the visual array (precue, spatial attention) or shortly after the array (postcue, iconic memory). Pre- and postcues led to similar activity modulations in lateral occipital cortex contralateral to the cued side. This finding indicates that readout from iconic memory can have some neural effects similar to those of spatial attention. We also found common bilateral activation of a fronto-parietal network for postcue and precue trials. These neuroimaging data suggest that some common neural mechanisms underlie selective spatial attention and readout from iconic memory. Some differences were also found; compared with precues, postcues led to higher activity in the right middle frontal gyrus.

  7. Readout From Iconic Memory and Selective Spatial Attention Involve Similar Neural Processes

    PubMed Central

    Ruff, Christian C; Kristjánsson, Árni; Driver, Jon

    2007-01-01

    Iconic memory and spatial attention are often considered separately, but they may have functional similarities. Here we provide functional magnetic resonance imaging evidence for some common underlying neural effects. Subjects judged three visual stimuli in one hemifield of a bilateral array comprising six stimuli. The relevant hemifield for partial report was indicated by an auditory cue, administered either before the visual array (precue, spatial attention) or shortly after the array (postcue, iconic memory). Pre- and postcues led to similar activity modulations in lateral occipital cortex contralateral to the cued side. This finding indicates that readout from iconic memory can have some neural effects similar to those of spatial attention. We also found common bilateral activation of a fronto-parietal network for postcue and precue trials. These neuroimaging data suggest that some common neural mechanisms underlie selective spatial attention and readout from iconic memory. Some differences were also found; compared with precues, postcues led to higher activity in the right middle frontal gyrus. PMID:17894608

  8. On evolutionary spatial heterogeneous games

    NASA Astrophysics Data System (ADS)

    Fort, H.

    2008-03-01

    How cooperation between self-interested individuals evolve is a crucial problem, both in biology and in social sciences, that is far from being well understood. Evolutionary game theory is a useful approach to this issue. The simplest model to take into account the spatial dimension in evolutionary games is in terms of cellular automata with just a one-parameter payoff matrix. Here, the effects of spatial heterogeneities of the environment and/or asymmetries in the interactions among the individuals are analysed through different extensions of this model. Instead of using the same universal payoff matrix, bimatrix games in which each cell at site ( i, j) has its own different ‘temptation to defect’ parameter T(i,j) are considered. First, the case in which these individual payoffs are constant in time is studied. Second, an evolving evolutionary spatial game such that T=T(i,j;t), i.e. besides depending on the position evolves (by natural selection), is used to explore the combination of spatial heterogeneity and natural selection of payoff matrices.

  9. Attention Modifies Spatial Resolution According to Task Demands

    PubMed Central

    Barbot, Antoine; Carrasco, Marisa

    2017-01-01

    How does visual attention affect spatial resolution? In texture-segmentation tasks, exogenous (involuntary) attention automatically increases resolution at the attended location, which improves performance where resolution is too low (at the periphery) but impairs performance where resolution is already too high (at central locations). Conversely, endogenous (voluntary) attention improves performance at all eccentricities, which suggests a more flexible mechanism. Here, using selective adaptation to spatial frequency, we investigated the mechanism by which endogenous attention benefits performance in resolution tasks. Participants detected a texture target that could appear at several eccentricities. Adapting to high or low spatial frequencies selectively affected performance in a manner consistent with changes in resolution. Moreover, adapting to high, but not low, frequencies mitigated the attentional benefit at central locations where resolution was too high; this shows that attention can improve performance by decreasing resolution. Altogether, our results indicate that endogenous attention benefits performance by modulating the contribution of high-frequency information in order to flexibly adjust spatial resolution according to task demands. PMID:28118103

  10. Learning place cells, grid cells and invariances with excitatory and inhibitory plasticity

    PubMed Central

    2018-01-01

    Neurons in the hippocampus and adjacent brain areas show a large diversity in their tuning to location and head direction, and the underlying circuit mechanisms are not yet resolved. In particular, it is unclear why certain cell types are selective to one spatial variable, but invariant to another. For example, place cells are typically invariant to head direction. We propose that all observed spatial tuning patterns – in both their selectivity and their invariance – arise from the same mechanism: Excitatory and inhibitory synaptic plasticity driven by the spatial tuning statistics of synaptic inputs. Using simulations and a mathematical analysis, we show that combined excitatory and inhibitory plasticity can lead to localized, grid-like or invariant activity. Combinations of different input statistics along different spatial dimensions reproduce all major spatial tuning patterns observed in rodents. Our proposed model is robust to changes in parameters, develops patterns on behavioral timescales and makes distinctive experimental predictions. PMID:29465399

  11. Selective verbal and spatial memory impairment after 5-HT1A and 5-HT2A receptor blockade in healthy volunteers pre-treated with an SSRI.

    PubMed

    Wingen, M; Kuypers, K P C; Ramaekers, J G

    2007-07-01

    Serotonergic neurotransmission has been implicated in memory impairment. It is unclear however if memory performance is mediated through general 5-HT availability, through specific 5-HT receptors or both. The aim of the present study was to assess the contribution of 5-HT reuptake inhibition and specific blockade of 5-HT(1A) and 5-HT(2A) receptors to memory impairment. The study was conducted according to a randomized, double-blind, placebo-controlled, four-way cross-over design including 16 healthy volunteers. The treatment consisted of oral administration of escitalopram 20 mg + placebo, escitalopram 20 mg + ketanserin 50 mg, escitalopram 20 mg + pindolol 10 mg and placebo on 4 separate days with a washout period of minimum 7 days. Different memory tasks were performed including verbal memory, spatial working memory and reversal learning. Escitalopram showed an impairing effect on immediate verbal recall which nearly reached statistical significance. No effects of escitalopram were found on other types of memory. In combination with pindolol, immediate verbal recall was significantly impaired. Escitalopram in combination with ketanserin impaired spatial working memory significantly. No effects were found on reversal learning. Selective impairment of immediate verbal recall after a 5-HT(1A) partial agonist and selective impairment of spatial working memory performance after 5-HT(2A) receptor antagonist, both in combination with a selective serotonergic reuptake inhibitor (escitalopram), suggests that 5-HT(1A) and 5-HT(2A) receptors are distinctly involved in verbal and spatial memory.

  12. Population-level resource selection by sympatric brown and American black bears in Alaska

    USGS Publications Warehouse

    Belant, Jerrold L.; Griffith, Brad; Zhang, Yingte; Follmann, Erich H.; Adams, Layne G.

    2010-01-01

    Distribution theory predicts that for two species living in sympatry, the subordinate species would be constrained from using the most suitable resources (e.g., habitat), resulting in its use of less suitable habitat and spatial segregation between species. We used negative binomial generalized linear mixed models with fixed effects to estimate seasonal population-level resource selection at two spatial resolutions for female brown bears (Ursus arctos) and female American black bears (U. americanus) in southcentral Alaska during May–September 2000. Black bears selected areas occupied by brown bears during spring which may be related to spatially restricted (i.e., restricted to low elevations) but dispersed or patchy availability of food. In contrast, black bears avoided areas occupied by brown bears during summer. Brown bears selected areas near salmon streams during summer, presumably to access spawning salmon. Use of areas with high berry production by black bears during summer appeared in response to avoidance of areas containing brown bears. Berries likely provided black bears a less nutritious, but adequate food source. We suggest that during summer, black bears were displaced by brown bears, which supports distribution theory in that black bears appeared to be partially constrained from areas containing salmon, resulting in their use of areas containing less nutritious forage. Spatial segregation of brown and American black bears apparently occurs when high-quality resources are spatially restricted and alternate resources are available to the subordinate species. This and previous work suggest that individual interactions between species can result in seasonal population-level responses.

  13. Spatial attention during saccade decisions.

    PubMed

    Jonikaitis, Donatas; Klapetek, Anna; Deubel, Heiner

    2017-07-01

    Behavioral measures of decision making are usually limited to observations of decision outcomes. In the present study, we made use of the fact that oculomotor and sensory selection are closely linked to track oculomotor decision making before oculomotor responses are made. We asked participants to make a saccadic eye movement to one of two memorized target locations and observed that visual sensitivity increased at both the chosen and the nonchosen saccade target locations, with a clear bias toward the chosen target. The time course of changes in visual sensitivity was related to saccadic latency, with the competition between the chosen and nonchosen targets resolved faster before short-latency saccades. On error trials, we observed an increased competition between the chosen and nonchosen targets. Moreover, oculomotor selection and visual sensitivity were influenced by top-down and bottom-up factors as well as by selection history and predicted the direction of saccades. Our findings demonstrate that saccade decisions have direct visual consequences and show that decision making can be traced in the human oculomotor system well before choices are made. Our results also indicate a strong association between decision making, saccade target selection, and visual sensitivity. NEW & NOTEWORTHY We show that saccadic decisions can be tracked by measuring spatial attention. Spatial attention is allocated in parallel to the two competing saccade targets, and the time course of spatial attention differs for fast-slow and for correct-erroneous decisions. Saccade decisions take the form of a competition between potential saccade goals, which is associated with spatial attention allocation to those locations. Copyright © 2017 the American Physiological Society.

  14. Developing Spatial Sense and Communication Skills

    ERIC Educational Resources Information Center

    Richardson, Kerri; Stein, Catherine

    2008-01-01

    This article describes how spatial instruction with preservice teachers can be implemented in a middle-grades mathematics methods class. A "Reflect and Discuss" section is included for professional development study. (Contains 4 figures.)

  15. Spatial variation in selection on corolla shape in a generalist plant is promoted by the preference patterns of its local pollinators.

    PubMed

    Gómez, José M; Bosch, Jordi; Perfectti, Francisco; Fernández, J D; Abdelaziz, Mohamed; Camacho, J P M

    2008-10-07

    An adaptive role of corolla shape has been often asserted without an empirical demonstration of how natural selection acts on this trait. In generalist plants, in which flowers are visited by diverse pollinator fauna that commonly vary spatially, detecting pollinator-mediated selection on corolla shape is even more difficult. In this study, we explore the mechanisms promoting selection on corolla shape in the generalist crucifer Erysimum mediohispanicum Polatschek (Brassicaceae). We found that the main pollinators of E. mediohispanicum (large bees, small bees and bee flies) discriminate between different corolla shapes when offered artificial flowers without reward. Importantly, different pollinators prefer different shapes: bees prefer flowers with narrow petals, whereas bee flies prefer flowers with rounded overlapping petals. We also found that flowers with narrow petals (those preferred by bees) produce both more pollen and nectar than those with rounded petals. Finally, different plant populations were visited by different faunas. As a result, we found spatial variation in the selection acting on corolla shape. Selection favoured flowers with narrow petals in the populations where large or small bees are the most abundant pollinator groups. Our study suggests that pollinators, by preferring flowers with high reward, exert strong selection on the E. mediohispanicum corolla shape. The geographical variation in the pollinator-mediated selection on E. mediohispanicum corolla shape suggests that phenotypic evolution and diversification can occur in this complex floral trait even without specialization.

  16. SADA: Ecological Risk Based Decision Support System for Selective Remediation

    EPA Science Inventory

    Spatial Analysis and Decision Assistance (SADA) is freeware that implements terrestrial ecological risk assessment and yields a selective remediation design using its integral geographical information system, based on ecological and risk assessment inputs. Selective remediation ...

  17. Is that a belt or a snake? object attentional selection affects the early stages of visual sensory processing

    PubMed Central

    2012-01-01

    Background There is at present crescent empirical evidence deriving from different lines of ERPs research that, unlike previously observed, the earliest sensory visual response, known as C1 component or P/N80, generated within the striate cortex, might be modulated by selective attention to visual stimulus features. Up to now, evidence of this modulation has been related to space location, and simple features such as spatial frequency, luminance, and texture. Additionally, neurophysiological conditions, such as emotion, vigilance, the reflexive or voluntary nature of input attentional selection, and workload have also been related to C1 modulations, although at least the workload status has received controversial indications. No information is instead available, at present, for objects attentional selection. Methods In this study object- and space-based attention mechanisms were conjointly investigated by presenting complex, familiar shapes of artefacts and animals, intermixed with distracters, in different tasks requiring the selection of a relevant target-category within a relevant spatial location, while ignoring the other shape categories within this location, and, overall, all the categories at an irrelevant location. EEG was recorded from 30 scalp electrode sites in 21 right-handed participants. Results and Conclusions ERP findings showed that visual processing was modulated by both shape- and location-relevance per se, beginning separately at the latency of the early phase of a precocious negativity (60-80 ms) at mesial scalp sites consistent with the C1 component, and a positivity at more lateral sites. The data also showed that the attentional modulation progressed conjointly at the latency of the subsequent P1 (100-120 ms) and N1 (120-180 ms), as well as later-latency components. These findings support the views that (1) V1 may be precociously modulated by direct top-down influences, and participates to object, besides simple features, attentional selection; (2) object spatial and non-spatial features selection might begin with an early, parallel detection of a target object in the visual field, followed by the progressive focusing of spatial attention onto the location of an actual target for its identification, somehow in line with neural mechanisms reported in the literature as "object-based space selection", or with those proposed for visual search. PMID:22300540

  18. Analysis of the impact of immigration on labour market using spatial models

    NASA Astrophysics Data System (ADS)

    Polonyankina, Tatiana

    2017-07-01

    This paper investigates the impact of immigration on employment and unemployment of a host country. The question to answer is: How does employment/unemployment in the host country change after an increase in number of immigrants? The analysis is taking into account only legal immigrants in recession period. The model is combining classical regression of cross-sectional data with spatial econometrics models where cross-section dependencies are captured by a spatial matrix. The intention is by using spatial models analyse the sensitivity of employment/unemployment rate on change in a share of immigration in a region. The used panel data are based on the Labour force survey and on available macro data in Eurostat for 3 European countries (Germany, Austria and Czech Republic) grouped into cells by NUTS regions in a recession period.

  19. Have Sex Differences in Spatial Ability Evolved from Male Competition for Mating and Female Concern for Survival?

    ERIC Educational Resources Information Center

    Ecuyer-Dab, Isabelle; Robert, Michele

    2004-01-01

    Drawing on the theoretical and empirical foundations of two evolutionary models, we argue that, among humans and other mammals, a twofold selection process would parsimoniously account for sex-linked advantages in spatial contexts. In males, a superiority for both solving navigation-related spatial problems and understanding physical principles…

  20. Sexual Orientation and Spatial Position Effects on Selective Forms of Object Location Memory

    ERIC Educational Resources Information Center

    Rahman, Qazi; Newland, Cherie; Smyth, Beatrice Mary

    2011-01-01

    Prior research has demonstrated robust sex and sexual orientation-related differences in object location memory in humans. Here we show that this sexual variation may depend on the spatial position of target objects and the task-specific nature of the spatial array. We tested the recovery of object locations in three object arrays (object…

  1. Mutualists and antagonists drive among-population variation in selection and evolution of floral display in a perennial herb

    PubMed Central

    Ågren, Jon; Hellström, Frida; Toräng, Per; Ehrlén, Johan

    2013-01-01

    Spatial variation in the direction of selection drives the evolution of adaptive differentiation. However, few experimental studies have examined the relative importance of different environmental factors for variation in selection and evolutionary trajectories in natural populations. Here, we combine 8 y of observational data and field experiments to assess the relative importance of mutualistic and antagonistic interactions for spatial variation in selection and short-term evolution of a genetically based floral display dimorphism in the short-lived perennial herb Primula farinosa. Natural populations of this species include two floral morphs: long-scaped plants that present their flowers well above the ground and short-scaped plants with flowers positioned close to the ground. The direction and magnitude of selection on scape morph varied among populations, and so did the frequency of the short morph (median 19%, range 0–100%; n = 69 populations). A field experiment replicated at four sites demonstrated that variation in the strength of interactions with grazers and pollinators were responsible for among-population differences in relative fitness of the two morphs. Selection exerted by grazers favored the short-scaped morph, whereas pollinator-mediated selection favored the long-scaped morph. Moreover, variation in selection among natural populations was associated with differences in morph frequency change, and the experimental removal of grazers at nine sites significantly reduced the frequency of the short-scaped morph over 8 y. The results demonstrate that spatial variation in intensity of grazing and pollination produces a selection mosaic, and that changes in biotic interactions can trigger rapid genetic changes in natural plant populations. PMID:24145439

  2. Mutualists and antagonists drive among-population variation in selection and evolution of floral display in a perennial herb.

    PubMed

    Agren, Jon; Hellström, Frida; Toräng, Per; Ehrlén, Johan

    2013-11-05

    Spatial variation in the direction of selection drives the evolution of adaptive differentiation. However, few experimental studies have examined the relative importance of different environmental factors for variation in selection and evolutionary trajectories in natural populations. Here, we combine 8 y of observational data and field experiments to assess the relative importance of mutualistic and antagonistic interactions for spatial variation in selection and short-term evolution of a genetically based floral display dimorphism in the short-lived perennial herb Primula farinosa. Natural populations of this species include two floral morphs: long-scaped plants that present their flowers well above the ground and short-scaped plants with flowers positioned close to the ground. The direction and magnitude of selection on scape morph varied among populations, and so did the frequency of the short morph (median 19%, range 0-100%; n = 69 populations). A field experiment replicated at four sites demonstrated that variation in the strength of interactions with grazers and pollinators were responsible for among-population differences in relative fitness of the two morphs. Selection exerted by grazers favored the short-scaped morph, whereas pollinator-mediated selection favored the long-scaped morph. Moreover, variation in selection among natural populations was associated with differences in morph frequency change, and the experimental removal of grazers at nine sites significantly reduced the frequency of the short-scaped morph over 8 y. The results demonstrate that spatial variation in intensity of grazing and pollination produces a selection mosaic, and that changes in biotic interactions can trigger rapid genetic changes in natural plant populations.

  3. Electrochemical impedance spectroscopy system and methods for determining spatial locations of defects

    DOEpatents

    Glenn, David F.; Matthern, Gretchen E.; Propp, W. Alan; Glenn, Anne W.; Shaw, Peter G.

    2006-08-08

    A method and apparatus for determining spatial locations of defects in a material are described. The method includes providing a plurality of electrodes in contact with a material, applying a sinusoidal voltage to a select number of the electrodes at a predetermined frequency, determining gain and phase angle measurements at other of the electrodes in response to applying the sinusoidal voltage to the select number of electrodes, determining impedance values from the gain and phase angle measurements, computing an impedance spectrum for an area of the material from the determined impedance values, and comparing the computed impedance spectrum with a known impedance spectrum to identify spatial locations of defects in the material.

  4. Effects of laterality and pitch height of an auditory accessory stimulus on horizontal response selection: the Simon effect and the SMARC effect.

    PubMed

    Nishimura, Akio; Yokosawa, Kazuhiko

    2009-08-01

    In the present article, we investigated the effects of pitch height and the presented ear (laterality) of an auditory stimulus, irrelevant to the ongoing visual task, on horizontal response selection. Performance was better when the response and the stimulated ear spatially corresponded (Simon effect), and when the spatial-musical association of response codes (SMARC) correspondence was maintained-that is, right (left) response with a high-pitched (low-pitched) tone. These findings reveal an automatic activation of spatially and musically associated responses by task-irrelevant auditory accessory stimuli. Pitch height is strong enough to influence the horizontal responses despite modality differences with task target.

  5. A Bayesian method for assessing multiscalespecies-habitat relationships

    USGS Publications Warehouse

    Stuber, Erica F.; Gruber, Lutz F.; Fontaine, Joseph J.

    2017-01-01

    ContextScientists face several theoretical and methodological challenges in appropriately describing fundamental wildlife-habitat relationships in models. The spatial scales of habitat relationships are often unknown, and are expected to follow a multi-scale hierarchy. Typical frequentist or information theoretic approaches often suffer under collinearity in multi-scale studies, fail to converge when models are complex or represent an intractable computational burden when candidate model sets are large.ObjectivesOur objective was to implement an automated, Bayesian method for inference on the spatial scales of habitat variables that best predict animal abundance.MethodsWe introduce Bayesian latent indicator scale selection (BLISS), a Bayesian method to select spatial scales of predictors using latent scale indicator variables that are estimated with reversible-jump Markov chain Monte Carlo sampling. BLISS does not suffer from collinearity, and substantially reduces computation time of studies. We present a simulation study to validate our method and apply our method to a case-study of land cover predictors for ring-necked pheasant (Phasianus colchicus) abundance in Nebraska, USA.ResultsOur method returns accurate descriptions of the explanatory power of multiple spatial scales, and unbiased and precise parameter estimates under commonly encountered data limitations including spatial scale autocorrelation, effect size, and sample size. BLISS outperforms commonly used model selection methods including stepwise and AIC, and reduces runtime by 90%.ConclusionsGiven the pervasiveness of scale-dependency in ecology, and the implications of mismatches between the scales of analyses and ecological processes, identifying the spatial scales over which species are integrating habitat information is an important step in understanding species-habitat relationships. BLISS is a widely applicable method for identifying important spatial scales, propagating scale uncertainty, and testing hypotheses of scaling relationships.

  6. Investing the temporal and spatial scale variations of luminescence sensitivity of loess in the Chinese Loess Plateau since the last interglacial

    NASA Astrophysics Data System (ADS)

    Lv, T.; Sun, J.; Gong, Z.

    2017-12-01

    The provenance of the eolian deposits on the Loess Plateau has long been one of the most important issues. Although the luminescence sensitivity of the quartz grains of desert sands has been used in tracing provenance, and the vertical variation of OSL sensitivity of Loess in the central Chinese Loess plateau (CLP) has been studied, it still remains uncertain about the temporal and spatial scale variations of luminescence sensitivity of loess. This paper chose the eolian deposits of Shimao (SM) section in the northern margin of the Chinese Loess Plateau and of Luochuan (LC) section in the central Chinese Loess Plateau. Firstly, the temporal scale variations of luminescence sensitivity of different quartz grians (38-64 and 64-90μm) from sand/loess of SM section have been studied respectively. Our results indicate that they both have similar trend in the strength of luminescence sensitivity, characterized by lower values in sand/loess beds and higher values in soils. The OSL sensitivity of quartz grains of the sand-loess-soil sequence shows very similar trend to the magnetic susceptibility fluctuations. Secondly, the spatial scale variations of luminescence sensitivity of loess in the Chinese Loess Plateau since the last interglacial were studied by comparing the values of SM section and LC section. The OSL sensitivity of quartz grains from the two sections since the last interglacial change synchronously. However, the OSL sensitivity values of quartz grains from the same loess/paleosol beds of LC section are higher than these values of SM section. We suggest that the temporal variation of OSL sensitivity of SM is main influenced by the retreat-advance of deserts. The spatial variation of OSL sensitivity mainly is due to the different sedimentary history, containing of repeated erosion, transport and deposition cycles which controlled by cyclic climatic change. The higher OSL sensitivity values of quartz grains in LC section relates of longer transport distance and of more sedimentary history than these values in SM section. Keywords: Luminescence sensitivity; Quartz; provenance; Loess Plateau

  7. Macro and micro geo-spatial environment consideration for landfill site selection in Sharjah, United Arab Emirates.

    PubMed

    Al-Ruzouq, Rami; Shanableh, Abdallah; Omar, Maher; Al-Khayyat, Ghadeer

    2018-02-17

    Waste management involves various procedures and resources for proper handling of waste materials in compliance with health codes and environmental regulations. Landfills are one of the oldest, most convenient, and cheapest methods to deposit waste. However, landfill utilization involves social, environmental, geotechnical, cost, and restrictive regulation considerations. For instance, landfills are considered a source of hazardous air pollutants that can cause health and environmental problems related to landfill gas and non-methanic organic compounds. The increasing number of sensors and availability of remotely sensed images along with rapid development of spatial technology are helping with effective landfill site selection. The present study used fuzzy membership and the analytical hierarchy process (AHP) in a geo-spatial environment for landfill site selection in the city of Sharjah, United Arab Emirates. Macro- and micro-level factors were considered; the macro-level contained social and economic factors, while the micro-level accounted for geo-environmental factors. The weighted spatial layers were combined to generate landfill suitability and overall suitability index maps. Sensitivity analysis was then carried out to rectify initial theoretical weights. The results showed that 30.25% of the study area had a high suitability index for landfill sites in the Sharjah, and the most suitable site was selected based on weighted factors. The developed fuzzy-AHP methodology can be applied in neighboring regions with similar geo-natural conditions.

  8. Time course of spatial and feature selective attention for partly-occluded objects.

    PubMed

    Kasai, Tetsuko; Takeya, Ryuji

    2012-07-01

    Attention selects objects/groups as the most fundamental units, and this may be achieved by an attention-spreading mechanism. Previous event-related potential (ERP) studies have found that attention-spreading is reflected by a decrease in the N1 spatial attention effect. The present study tested whether the electrophysiological attention effect is associated with the perception of object unity or amodal completion through the use of partly-occluded objects. ERPs were recorded in 14 participants who were required to pay attention to their left or right visual field and to press a button for a target shape in the attended field. Bilateral stimuli were presented rapidly, and were separated, connected, or connected behind an occluder. Behavioral performance in the connected and occluded conditions was worse than that in the separated condition, indicating that attention spread over perceptual object representations after amodal completion. Consistently, the late N1 spatial attention effect (180-220 ms post-stimulus) and the early phase (230-280 ms) of feature selection effects (target N2) at contralateral sites decreased, equally for the occluded and connected conditions, while the attention effect in the early N1 latency (140-180 ms) shifted most positively for the occluded condition. These results suggest that perceptual organization processes for object recognition transiently modulate spatial and feature selection processes in the visual cortex. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. Procedural Factors That Affect Psychophysical Measures of Spatial Selectivity in Cochlear Implant Users

    PubMed Central

    Deeks, John M.; Carlyon, Robert P.

    2015-01-01

    Behavioral measures of spatial selectivity in cochlear implants are important both for guiding the programing of individual users’ implants and for the evaluation of different stimulation methods. However, the methods used are subject to a number of confounding factors that can contaminate estimates of spatial selectivity. These factors include off-site listening, charge interactions between masker and probe pulses in interleaved masking paradigms, and confusion effects in forward masking. We review the effects of these confounds and discuss methods for minimizing them. We describe one such method in which the level of a 125-pps masker is adjusted so as to mask a 125-pps probe, and where the masker and probe pulses are temporally interleaved. Five experiments describe the method and evaluate the potential roles of the different potential confounding factors. No evidence was obtained for off-site listening of the type observed in acoustic hearing. The choice of the masking paradigm was shown to alter the measured spatial selectivity. For short gaps between masker and probe pulses, both facilitation and refractory mechanisms had an effect on masking; this finding should inform the choice of stimulation rate in interleaved masking experiments. No evidence for confusion effects in forward masking was revealed. It is concluded that the proposed method avoids many potential confounds but that the choice of method should depend on the research question under investigation. PMID:26420785

  10. Masking reduces orientation selectivity in rat visual cortex

    PubMed Central

    Alwis, Dasuni S.; Richards, Katrina L.

    2016-01-01

    In visual masking the perception of a target stimulus is impaired by a preceding (forward) or succeeding (backward) mask stimulus. The illusion is of interest because it allows uncoupling of the physical stimulus, its neuronal representation, and its perception. To understand the neuronal correlates of masking, we examined how masks affected the neuronal responses to oriented target stimuli in the primary visual cortex (V1) of anesthetized rats (n = 37). Target stimuli were circular gratings with 12 orientations; mask stimuli were plaids created as a binarized sum of all possible target orientations. Spatially, masks were presented either overlapping or surrounding the target. Temporally, targets and masks were presented for 33 ms, but the stimulus onset asynchrony (SOA) of their relative appearance was varied. For the first time, we examine how spatially overlapping and center-surround masking affect orientation discriminability (rather than visibility) in V1. Regardless of the spatial or temporal arrangement of stimuli, the greatest reductions in firing rate and orientation selectivity occurred for the shortest SOAs. Interestingly, analyses conducted separately for transient and sustained target response components showed that changes in orientation selectivity do not always coincide with changes in firing rate. Given the near-instantaneous reductions observed in orientation selectivity even when target and mask do not spatially overlap, we suggest that monotonic visual masking is explained by a combination of neural integration and lateral inhibition. PMID:27535373

  11. Spatial Frequency Selectivity Is Impaired in Dopamine D2 Receptor Knockout Mice

    PubMed Central

    Souza, Bruno Oliveira Ferreira; Abou Rjeili, Mira; Quintana, Clémentine; Beaulieu, Jean M.; Casanova, Christian

    2018-01-01

    Dopamine is a neurotransmitter implicated in several brain functions, including vision. In the present study, we investigated the impacts of the lack of D2 dopamine receptors on the structure and function of the primary visual cortex (V1) of D2-KO mice using optical imaging of intrinsic signals. Retinotopic maps were generated in order to measure anatomo-functional parameters such as V1 shape, cortical magnification factor, scatter, and ocular dominance. Contrast sensitivity and spatial frequency selectivity (SF) functions were computed from responses to drifting gratings. When compared to control mice, none of the parameters of the retinotopic maps were affected by D2 receptor loss of function. While the contrast sensitivity function of D2-KO mice did not differ from their wild-type counterparts, SF selectivity function was significantly affected as the optimal SF and the high cut-off frequency (p < 0.01) were higher in D2-KO than in WT mice. These findings show that the lack of function of D2 dopamine receptors had no influence on cortical structure whereas it had a significant impact on the spatial frequency selectivity and high cut-off. Taken together, our results suggest that D2 receptors play a specific role on the processing of spatial features in early visual cortex while they do not seem to participate in its development. PMID:29379422

  12. Real-time 2D spatially selective MRI experiments: Comparative analysis of optimal control design methods

    NASA Astrophysics Data System (ADS)

    Maximov, Ivan I.; Vinding, Mads S.; Tse, Desmond H. Y.; Nielsen, Niels Chr.; Shah, N. Jon

    2015-05-01

    There is an increasing need for development of advanced radio-frequency (RF) pulse techniques in modern magnetic resonance imaging (MRI) systems driven by recent advancements in ultra-high magnetic field systems, new parallel transmit/receive coil designs, and accessible powerful computational facilities. 2D spatially selective RF pulses are an example of advanced pulses that have many applications of clinical relevance, e.g., reduced field of view imaging, and MR spectroscopy. The 2D spatially selective RF pulses are mostly generated and optimised with numerical methods that can handle vast controls and multiple constraints. With this study we aim at demonstrating that numerical, optimal control (OC) algorithms are efficient for the design of 2D spatially selective MRI experiments, when robustness towards e.g. field inhomogeneity is in focus. We have chosen three popular OC algorithms; two which are gradient-based, concurrent methods using first- and second-order derivatives, respectively; and a third that belongs to the sequential, monotonically convergent family. We used two experimental models: a water phantom, and an in vivo human head. Taking into consideration the challenging experimental setup, our analysis suggests the use of the sequential, monotonic approach and the second-order gradient-based approach as computational speed, experimental robustness, and image quality is key. All algorithms used in this work were implemented in the MATLAB environment and are freely available to the MRI community.

  13. Extracting spatial information from large aperture exposures of diffuse sources

    NASA Technical Reports Server (NTRS)

    Clarke, J. T.; Moos, H. W.

    1981-01-01

    The spatial properties of large aperture exposures of diffuse emission can be used both to investigate spatial variations in the emission and to filter out camera noise in exposures of weak emission sources. Spatial imaging can be accomplished both parallel and perpendicular to dispersion with a resolution of 5-6 arc sec, and a narrow median filter running perpendicular to dispersion across a diffuse image selectively filters out point source features, such as reseaux marks and fast particle hits. Spatial information derived from observations of solar system objects is presented.

  14. A Geospatial Database for Wind and Solar Energy Applications: The Kingdom of Bahrain Study Case

    NASA Astrophysics Data System (ADS)

    Al-Joburi, Khalil; Dahman, Nidal

    2017-11-01

    This research is aimed at designing, implementing, and testing a geospatial database for wind and solar energy applications in the Kingdom of Bahrain. All decision making needed to determine economic feasibility and establish site location for wind turbines or solar panels depends primarily on geospatial feature theme information and non-spatial (attribute) data for wind, solar, rainfall, temperature and weather characteristics of a particular region. Spatial data includes, but is not limited to, digital elevation, slopes, land use, zonings, parks, population density, road utility maps, and other related information. Digital elevations for over 450,000 spot at 50 m spatial horizontal resolution plus field surveying and GPS (at selected locations) was obtained from the Surveying and Land Registration Bureau (SLRB). Road, utilities, and population density are obtained from the Central Information Organization (CIO). Land use zoning, recreational parks, and other data are obtained from the Ministry of Municipalities and Agricultural Affairs. Wind, solar, humidity, rainfall, and temperature data are obtained from the Ministry of Transportation, Civil Aviation Section. LandSat Satellite and others images are obtained from NASA and online sources respectively. The collected geospatial data was geo-referenced to Ain el-Abd UTM Zone 39 North. 3D Digital Elevation Model (DEM)-50 m spatial resolutions was created using SLRB spot elevations. Slope and aspect maps were generate based on the DEM. Supervised image classification to identify open spaces was performed utilizing satellite images. Other geospatial data was converted to raster format with the same cell resolution. Non-spatial data are entered as an attribute to spatial features. To eliminate ambiguous solution, multi-criteria GIS model is developed based on, vector (discrete point, line, and polygon representations) as well as raster model (continuous representation). The model was tested at the Al-Areen proposed project, a relatively small area (15 km2). Optimum site spatial location for the location of wind turbines and solar panels was determined and initial results indicates that the combination of wind and solar energy would be sufficient for the project to meet the energy demand at the present per capita consummation rate..

  15. Photo ion spectrometer

    DOEpatents

    Gruen, Dieter M.; Young, Charles E.; Pellin, Michael J.

    1992-01-01

    A thin film structure for providing predetermined electric field boundary conditions. A thin film configuration is disposed on an insulator substrate in a selected spatial pattern with substantially uniform electrically resistive character in each of the different areas of the spatial pattern.

  16. Photo-ion spectrometer

    DOEpatents

    Gruen, D.M.; Young, C.E.; Pellin, M.J.

    1992-03-17

    A thin film structure for providing predetermined electric field boundary conditions. A thin film configuration is disposed on an insulator substrate in a selected spatial pattern with substantially uniform electrically resistive character in each of the different areas of the spatial pattern.

  17. Sensorineural hearing loss degrades behavioral and physiological measures of human spatial selective auditory attention

    PubMed Central

    Dai, Lengshi; Best, Virginia; Shinn-Cunningham, Barbara G.

    2018-01-01

    Listeners with sensorineural hearing loss often have trouble understanding speech amid other voices. While poor spatial hearing is often implicated, direct evidence is weak; moreover, studies suggest that reduced audibility and degraded spectrotemporal coding may explain such problems. We hypothesized that poor spatial acuity leads to difficulty deploying selective attention, which normally filters out distracting sounds. In listeners with normal hearing, selective attention causes changes in the neural responses evoked by competing sounds, which can be used to quantify the effectiveness of attentional control. Here, we used behavior and electroencephalography to explore whether control of selective auditory attention is degraded in hearing-impaired (HI) listeners. Normal-hearing (NH) and HI listeners identified a simple melody presented simultaneously with two competing melodies, each simulated from different lateral angles. We quantified performance and attentional modulation of cortical responses evoked by these competing streams. Compared with NH listeners, HI listeners had poorer sensitivity to spatial cues, performed more poorly on the selective attention task, and showed less robust attentional modulation of cortical responses. Moreover, across NH and HI individuals, these measures were correlated. While both groups showed cortical suppression of distracting streams, this modulation was weaker in HI listeners, especially when attending to a target at midline, surrounded by competing streams. These findings suggest that hearing loss interferes with the ability to filter out sound sources based on location, contributing to communication difficulties in social situations. These findings also have implications for technologies aiming to use neural signals to guide hearing aid processing. PMID:29555752

  18. Enhanced Sensitivity for High Spatial Resolution Lipid Analysis by Negative Ion Mode MALDI Imaging Mass Spectrometry

    PubMed Central

    Angel, Peggi M.; Spraggins, Jeffrey M.; Baldwin, H. Scott; Caprioli, Richard

    2012-01-01

    We have achieved enhanced lipid imaging to a ~10 μm spatial resolution using negative ion mode matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry, sublimation of 2,5-dihydroxybenzoic acid as the MALDI matrix and a sample preparation protocol that uses aqueous washes. We report on the effect of treating tissue sections by washing with volatile buffers at different pHs prior to negative ion mode lipid imaging. The results show that washing with ammonium formate, pH 6.4, or ammonium acetate, pH 6.7, significantly increases signal intensity and number of analytes recorded from adult mouse brain tissue sections. Major lipid species measured were glycerophosphoinositols, glycerophosphates, glycerolphosphoglycerols, glycerophosphoethanolamines, glycerophospho-serines, sulfatides, and gangliosides. Ion images from adult mouse brain sections that compare washed and unwashed sections are presented and show up to fivefold increases in ion intensity for washed tissue. The sample preparation protocol has been found to be applicable across numerous organ types and significantly expands the number of lipid species detectable by imaging mass spectrometry at high spatial resolution. PMID:22243218

  19. ViSA: a neurodynamic model for visuo-spatial working memory, attentional blink, and conscious access.

    PubMed

    Simione, Luca; Raffone, Antonino; Wolters, Gezinus; Salmas, Paola; Nakatani, Chie; Belardinelli, Marta Olivetti; van Leeuwen, Cees

    2012-10-01

    Two separate lines of study have clarified the role of selectivity in conscious access to visual information. Both involve presenting multiple targets and distracters: one simultaneously in a spatially distributed fashion, the other sequentially at a single location. To understand their findings in a unified framework, we propose a neurodynamic model for Visual Selection and Awareness (ViSA). ViSA supports the view that neural representations for conscious access and visuo-spatial working memory are globally distributed and are based on recurrent interactions between perceptual and access control processors. Its flexible global workspace mechanisms enable a unitary account of a broad range of effects: It accounts for the limited storage capacity of visuo-spatial working memory, attentional cueing, and efficient selection with multi-object displays, as well as for the attentional blink and associated sparing and masking effects. In particular, the speed of consolidation for storage in visuo-spatial working memory in ViSA is not fixed but depends adaptively on the input and recurrent signaling. Slowing down of consolidation due to weak bottom-up and recurrent input as a result of brief presentation and masking leads to the attentional blink. Thus, ViSA goes beyond earlier 2-stage and neuronal global workspace accounts of conscious processing limitations. PsycINFO Database Record (c) 2012 APA, all rights reserved.

  20. Front-Presented Looming Sound Selectively Alters the Perceived Size of a Visual Looming Object.

    PubMed

    Yamasaki, Daiki; Miyoshi, Kiyofumi; Altmann, Christian F; Ashida, Hiroshi

    2018-07-01

    In spite of accumulating evidence for the spatial rule governing cross-modal interaction according to the spatial consistency of stimuli, it is still unclear whether 3D spatial consistency (i.e., front/rear of the body) of stimuli also regulates audiovisual interaction. We investigated how sounds with increasing/decreasing intensity (looming/receding sound) presented from the front and rear space of the body impact the size perception of a dynamic visual object. Participants performed a size-matching task (Experiments 1 and 2) and a size adjustment task (Experiment 3) of visual stimuli with increasing/decreasing diameter, while being exposed to a front- or rear-presented sound with increasing/decreasing intensity. Throughout these experiments, we demonstrated that only the front-presented looming sound caused overestimation of the spatially consistent looming visual stimulus in size, but not of the spatially inconsistent and the receding visual stimulus. The receding sound had no significant effect on vision. Our results revealed that looming sound alters dynamic visual size perception depending on the consistency in the approaching quality and the front-rear spatial location of audiovisual stimuli, suggesting that the human brain differently processes audiovisual inputs based on their 3D spatial consistency. This selective interaction between looming signals should contribute to faster detection of approaching threats. Our findings extend the spatial rule governing audiovisual interaction into 3D space.

  1. Spatial and symbolic queries for 3D image data

    NASA Astrophysics Data System (ADS)

    Benson, Daniel C.; Zick, Gregory L.

    1992-04-01

    We present a query system for an object-oriented biomedical imaging database containing 3-D anatomical structures and their corresponding 2-D images. The graphical interface facilitates the formation of spatial queries, nonspatial or symbolic queries, and combined spatial/symbolic queries. A query editor is used for the creation and manipulation of 3-D query objects as volumes, surfaces, lines, and points. Symbolic predicates are formulated through a combination of text fields and multiple choice selections. Query results, which may include images, image contents, composite objects, graphics, and alphanumeric data, are displayed in multiple views. Objects returned by the query may be selected directly within the views for further inspection or modification, or for use as query objects in subsequent queries. Our image database query system provides visual feedback and manipulation of spatial query objects, multiple views of volume data, and the ability to combine spatial and symbolic queries. The system allows for incremental enhancement of existing objects and the addition of new objects and spatial relationships. The query system is designed for databases containing symbolic and spatial data. This paper discuses its application to data acquired in biomedical 3- D image reconstruction, but it is applicable to other areas such as CAD/CAM, geographical information systems, and computer vision.

  2. Assessing the performance of multiple spectral-spatial features of a hyperspectral image for classification of urban land cover classes using support vector machines and artificial neural network

    NASA Astrophysics Data System (ADS)

    Pullanagari, Reddy; Kereszturi, Gábor; Yule, Ian J.; Ghamisi, Pedram

    2017-04-01

    Accurate and spatially detailed mapping of complex urban environments is essential for land managers. Classifying high spectral and spatial resolution hyperspectral images is a challenging task because of its data abundance and computational complexity. Approaches with a combination of spectral and spatial information in a single classification framework have attracted special attention because of their potential to improve the classification accuracy. We extracted multiple features from spectral and spatial domains of hyperspectral images and evaluated them with two supervised classification algorithms; support vector machines (SVM) and an artificial neural network. The spatial features considered are produced by a gray level co-occurrence matrix and extended multiattribute profiles. All of these features were stacked, and the most informative features were selected using a genetic algorithm-based SVM. After selecting the most informative features, the classification model was integrated with a segmentation map derived using a hidden Markov random field. We tested the proposed method on a real application of a hyperspectral image acquired from AisaFENIX and on widely used hyperspectral images. From the results, it can be concluded that the proposed framework significantly improves the results with different spectral and spatial resolutions over different instrumentation.

  3. The effect of spatial organization of targets and distractors on the capacity to selectively memorize objects in visual short-term memory

    PubMed Central

    Abbes, Aymen Ben; Gavault, Emmanuelle; Ripoll, Thierry

    2014-01-01

    We conducted a series of experiments to explore how the spatial configuration of objects influences the selection and the processing of these objects in a visual short-term memory task. We designed a new experiment in which participants had to memorize 4 targets presented among 4 distractors. Targets were cued during the presentation of distractor objects. Their locations varied according to 4 spatial configurations. From the first to the last configuration, the distance between targets’ locations was progressively increased. The results revealed a high capacity to select and memorize targets embedded among distractors even when targets were extremely distant from each other. This capacity is discussed in relation to the unitary conception of attention, models of split attention, and the competitive interaction model. Finally, we propose that the spatial dispersion of objects has different effects on attentional allocation and processing stages. Thus, when targets are extremely distant from each other, attentional allocation becomes more difficult while processing becomes easier. This finding implicates that these 2 aspects of attention need to be more clearly distinguished in future research. PMID:25339978

  4. Spatially-Correlated Risk in Nature Reserve Site Selection

    PubMed Central

    Albers, Heidi J.; Busby, Gwenlyn M.; Hamaide, Bertrand; Ando, Amy W.; Polasky, Stephen

    2016-01-01

    Establishing nature reserves protects species from land cover conversion and the resulting loss of habitat. Even within a reserve, however, many factors such as fires and defoliating insects still threaten habitat and the survival of species. To address the risk to species survival after reserve establishment, reserve networks can be created that allow some redundancy of species coverage to maximize the expected number of species that survive in the presence of threats. In some regions, however, the threats to species within a reserve may be spatially correlated. As examples, fires, diseases, and pest infestations can spread from a starting point and threaten neighboring parcels’ habitats, in addition to damage caused at the initial location. This paper develops a reserve site selection optimization framework that compares the optimal reserve networks in cases where risks do and do not reflect spatial correlation. By exploring the impact of spatially-correlated risk on reserve networks on a stylized landscape and on an Oregon landscape, this analysis demonstrates an appropriate and feasible method for incorporating such post-reserve establishment risks in the reserve site selection literature as an additional tool to be further developed for future conservation planning. PMID:26789127

  5. Neural Codes for One's Own Position and Direction in a Real-World "Vista" Environment.

    PubMed

    Sulpizio, Valentina; Boccia, Maddalena; Guariglia, Cecilia; Galati, Gaspare

    2018-01-01

    Humans, like animals, rely on an accurate knowledge of one's spatial position and facing direction to keep orientated in the surrounding space. Although previous neuroimaging studies demonstrated that scene-selective regions (the parahippocampal place area or PPA, the occipital place area or OPA and the retrosplenial complex or RSC), and the hippocampus (HC) are implicated in coding position and facing direction within small-(room-sized) and large-scale navigational environments, little is known about how these regions represent these spatial quantities in a large open-field environment. Here, we used functional magnetic resonance imaging (fMRI) in humans to explore the neural codes of these navigationally-relevant information while participants viewed images which varied for position and facing direction within a familiar, real-world circular square. We observed neural adaptation for repeated directions in the HC, even if no navigational task was required. Further, we found that the amount of knowledge of the environment interacts with the PPA selectivity in encoding positions: individuals who needed more time to memorize positions in the square during a preliminary training task showed less neural attenuation in this scene-selective region. We also observed adaptation effects, which reflect the real distances between consecutive positions, in scene-selective regions but not in the HC. When examining the multi-voxel patterns of activity we observed that scene-responsive regions and the HC encoded both spatial information and that the RSC classification accuracy for positions was higher in individuals scoring higher to a self-reported questionnaire of spatial abilities. Our findings provide new insight into how the human brain represents a real, large-scale "vista" space, demonstrating the presence of neural codes for position and direction in both scene-selective and hippocampal regions, and revealing the existence, in the former regions, of a map-like spatial representation reflecting real-world distance between consecutive positions.

  6. Identifying and Prioritizing Greater Sage-Grouse Nesting and Brood-Rearing Habitat for Conservation in Human-Modified Landscapes

    PubMed Central

    Dzialak, Matthew R.; Olson, Chad V.; Harju, Seth M.; Webb, Stephen L.; Mudd, James P.; Winstead, Jeffrey B.; Hayden-Wing, L.D.

    2011-01-01

    Background Balancing animal conservation and human use of the landscape is an ongoing scientific and practical challenge throughout the world. We investigated reproductive success in female greater sage-grouse (Centrocercus urophasianus) relative to seasonal patterns of resource selection, with the larger goal of developing a spatially-explicit framework for managing human activity and sage-grouse conservation at the landscape level. Methodology/Principal Findings We integrated field-observation, Global Positioning Systems telemetry, and statistical modeling to quantify the spatial pattern of occurrence and risk during nesting and brood-rearing. We linked occurrence and risk models to provide spatially-explicit indices of habitat-performance relationships. As part of the analysis, we offer novel biological information on resource selection during egg-laying, incubation, and night. The spatial pattern of occurrence during all reproductive phases was driven largely by selection or avoidance of terrain features and vegetation, with little variation explained by anthropogenic features. Specifically, sage-grouse consistently avoided rough terrain, selected for moderate shrub cover at the patch level (within 90 m2), and selected for mesic habitat in mid and late brood-rearing phases. In contrast, risk of nest and brood failure was structured by proximity to anthropogenic features including natural gas wells and human-created mesic areas, as well as vegetation features such as shrub cover. Conclusions/Significance Risk in this and perhaps other human-modified landscapes is a top-down (i.e., human-mediated) process that would most effectively be minimized by developing a better understanding of specific mechanisms (e.g., predator subsidization) driving observed patterns, and using habitat-performance indices such as those developed herein for spatially-explicit guidance of conservation intervention. Working under the hypothesis that industrial activity structures risk by enhancing predator abundance or effectiveness, we offer specific recommendations for maintaining high-performance habitat and reducing low-performance habitat, particularly relative to the nesting phase, by managing key high-risk anthropogenic features such as industrial infrastructure and water developments. PMID:22022587

  7. Cholinergic, But Not Dopaminergic or Noradrenergic, Enhancement Sharpens Visual Spatial Perception in Humans

    PubMed Central

    Wallace, Deanna L.

    2017-01-01

    The neuromodulator acetylcholine modulates spatial integration in visual cortex by altering the balance of inputs that generate neuronal receptive fields. These cholinergic effects may provide a neurobiological mechanism underlying the modulation of visual representations by visual spatial attention. However, the consequences of cholinergic enhancement on visuospatial perception in humans are unknown. We conducted two experiments to test whether enhancing cholinergic signaling selectively alters perceptual measures of visuospatial interactions in human subjects. In Experiment 1, a double-blind placebo-controlled pharmacology study, we measured how flanking distractors influenced detection of a small contrast decrement of a peripheral target, as a function of target-flanker distance. We found that cholinergic enhancement with the cholinesterase inhibitor donepezil improved target detection, and modeling suggested that this was mainly due to a narrowing of the extent of facilitatory perceptual spatial interactions. In Experiment 2, we tested whether these effects were selective to the cholinergic system or would also be observed following enhancements of related neuromodulators dopamine or norepinephrine. Unlike cholinergic enhancement, dopamine (bromocriptine) and norepinephrine (guanfacine) manipulations did not improve performance or systematically alter the spatial profile of perceptual interactions between targets and distractors. These findings reveal mechanisms by which cholinergic signaling influences visual spatial interactions in perception and improves processing of a visual target among distractors, effects that are notably similar to those of spatial selective attention. SIGNIFICANCE STATEMENT Acetylcholine influences how visual cortical neurons integrate signals across space, perhaps providing a neurobiological mechanism for the effects of visual selective attention. However, the influence of cholinergic enhancement on visuospatial perception remains unknown. Here we demonstrate that cholinergic enhancement improves detection of a target flanked by distractors, consistent with sharpened visuospatial perceptual representations. Furthermore, whereas most pharmacological studies focus on a single neurotransmitter, many neuromodulators can have related effects on cognition and perception. Thus, we also demonstrate that enhancing noradrenergic and dopaminergic systems does not systematically improve visuospatial perception or alter its tuning. Our results link visuospatial tuning effects of acetylcholine at the neuronal and perceptual levels and provide insights into the connection between cholinergic signaling and visual attention. PMID:28336568

  8. The (Spatial) Memory Game: Testing the Relationship Between Spatial Language, Object Knowledge, and Spatial Cognition.

    PubMed

    Gudde, Harmen B; Griffiths, Debra; Coventry, Kenny R

    2018-02-19

    The memory game paradigm is a behavioral procedure to explore the relationship between language, spatial memory, and object knowledge. Using two different versions of the paradigm, spatial language use and memory for object location are tested under different, experimentally manipulated conditions. This allows us to tease apart proposed models explaining the influence of object knowledge on spatial language (e.g., spatial demonstratives), and spatial memory, as well as understanding the parameters that affect demonstrative choice and spatial memory more broadly. Key to the development of the method was the need to collect data on language use (e.g., spatial demonstratives: "this/that") and spatial memory data under strictly controlled conditions, while retaining a degree of ecological validity. The language version (section 3.1) of the memory game tests how conditions affect language use. Participants refer verbally to objects placed at different locations (e.g., using spatial demonstratives: "this/that red circle"). Different parameters can be experimentally manipulated: the distance from the participant, the position of a conspecific, and for example whether the participant owns, knows, or sees the object while referring to it. The same parameters can be manipulated in the memory version of the memory game (section 3.2). This version tests the effects of the different conditions on object-location memory. Following object placement, participants get 10 seconds to memorize the object's location. After the object and location cues are removed, participants verbally direct the experimenter to move a stick to indicate where the object was. The difference between the memorized and the actual location shows the direction and strength of the memory error, allowing comparisons between the influences of the respective parameters.

  9. Relationship of Pupils' Spatial Perception and Ability with Their Performance in Geography

    ERIC Educational Resources Information Center

    Likouri, Anna-Aikaterini; Klonari, Aikaterini; Flouris, George

    2017-01-01

    The aim of this study was to investigate the correlation between pupils' spatial perception and abilities and their performance in geography. The sample was 600 6th-grade pupils from various areas of Greece selected by the cluster sampling method. The study results showed that: a) the vast majority of pupils showed low spatial ability; b) there…

  10. Nonlinear optical coupler using a doped optical waveguide

    DOEpatents

    Pantell, Richard H.; Sadowski, Robert W.; Digonnet, Michel J. F.; Shaw, Herbert J.

    1994-01-01

    An optical mode coupling apparatus includes an Erbium-doped optical waveguide in which an optical signal at a signal wavelength propagates in a first spatial propagation mode and a second spatial propagation mode of the waveguide. The optical signal propagating in the waveguide has a beat length. The coupling apparatus includes a pump source of perturbational light signal at a perturbational wavelength that propagates in the waveguide in the first spatial propagation mode. The perturbational signal has a sufficient intensity distribution in the waveguide that it causes a perturbation of the effective refractive index of the first spatial propagation mode of the waveguide in accordance with the optical Kerr effect. The perturbation of the effective refractive index of the first spatial propagation mode of the optical waveguide causes a change in the differential phase delay in the optical signal propagating in the first and second spatial propagation modes. The change in the differential phase delay is detected as a change in the intensity distribution between two lobes of the optical intensity distribution pattern of an output signal. The perturbational light signal can be selectively enabled and disabled to selectively change the intensity distribution in the two lobes of the optical intensity distribution pattern.

  11. Interface Design Implications for Recalling the Spatial Configuration of Virtual Auditory Environments

    NASA Astrophysics Data System (ADS)

    McMullen, Kyla A.

    Although the concept of virtual spatial audio has existed for almost twenty-five years, only in the past fifteen years has modern computing technology enabled the real-time processing needed to deliver high-precision spatial audio. Furthermore, the concept of virtually walking through an auditory environment did not exist. The applications of such an interface have numerous potential uses. Spatial audio has the potential to be used in various manners ranging from enhancing sounds delivered in virtual gaming worlds to conveying spatial locations in real-time emergency response systems. To incorporate this technology in real-world systems, various concerns should be addressed. First, to widely incorporate spatial audio into real-world systems, head-related transfer functions (HRTFs) must be inexpensively created for each user. The present study further investigated an HRTF subjective selection procedure previously developed within our research group. Users discriminated auditory cues to subjectively select their preferred HRTF from a publicly available database. Next, the issue of training to find virtual sources was addressed. Listeners participated in a localization training experiment using their selected HRTFs. The training procedure was created from the characterization of successful search strategies in prior auditory search experiments. Search accuracy significantly improved after listeners performed the training procedure. Next, in the investigation of auditory spatial memory, listeners completed three search and recall tasks with differing recall methods. Recall accuracy significantly decreased in tasks that required the storage of sound source configurations in memory. To assess the impacts of practical scenarios, the present work assessed the performance effects of: signal uncertainty, visual augmentation, and different attenuation modeling. Fortunately, source uncertainty did not affect listeners' ability to recall or identify sound sources. The present study also found that the presence of visual reference frames significantly increased recall accuracy. Additionally, the incorporation of drastic attenuation significantly improved environment recall accuracy. Through investigating the aforementioned concerns, the present study made initial footsteps guiding the design of virtual auditory environments that support spatial configuration recall.

  12. Ask the experts how to treat individuals with spatial neglect: a survey study.

    PubMed

    Chen, Peii; Pitteri, Marco; Gillen, Glen; Ayyala, Harsha

    2017-07-11

    Spatial neglect (SN) impedes rehabilitation success and leaves long-term consequences. We asked experts to provide their opinions in addressing SN by scenario (ideal vs. reality) and by recovery phase (earliest, acute, subacute, and chronic). Experts were individuals who have assessed or treated patients with SN clinically. This study was conducted using an anonymous survey on the Internet with 189 responders over 3 months. Located in 23 different countries, 127 experts of seven disciplines were included (occupational therapy, physical therapy, nursing, speech and language pathology or therapy, neurology, physical medicine and rehabilitation, and psychology or neuropsychology). Comparing the two scenarios, more treatments were selected in the ideal than in the reality scenario for all recovery phases except for the chronic phase. In both scenarios, (1) more treatments were selected in acute and subacute phases than in earliest or chronic phases, (2) less experienced experts selected diverse treatment options more often, and (3) highly experienced experts were more likely to provide their reasons of treatment selection, suggestions of treatment delivery methods, and other insights. Finally, 83.7% reported obstacles in treating SN. Experts' treatment selections are consistent with current evidence and practice guidelines. Recognizing the limitation of evidence, their opinions may help generate ideas in various topics (e.g., dosing, integrative intervention, and treatment implementation) to be examined in future studies. Implications for Rehabilitation Clinicians with experience in treating people with spatial neglect (i.e., experts as defined in the present study) recognized the limitation of evidence but nonetheless suggested specific treatments by recovery phase. In both the reality and ideal scenarios, experts included visual scanning, active limb activation, and sustained attention training in the top-five selections. Prism adaptation was in the top-five selections in the ideal scenario, while in the reality scenario, it was in the top-five in all phases except for the earliest phase where it was the sixth most selected. They also shared their valuable opinions in when to use which treatment to address spatial neglect and how to deliver certain interventions, which may help to generate ideas in various topics (e.g., dosing, integrative intervention, knowledge dissemination, and treatment implementation) that can be examined in future studies. We suggest that (1) clinicians consider collective expert opinions reported here to enhance their clinical judgment and practices, (2) researchers develop studies focused on treatments with limited evidence but selected here by experts, and (3) funding agencies provide the means to research and implementation projects that will generate rich information for improving practice guidelines and rehabilitation outcomes for patients with spatial neglect. The majority of the experts reported some obstacles in providing treatment for spatial neglect, and time and equipment shortages were the most common barriers, which should be addressed at the system level to determine whether removing those barriers have long-term beneficial impacts on both patients and healthcare systems.

  13. Spatial and Feature-Based Attention in a Layered Cortical Microcircuit Model

    PubMed Central

    Wagatsuma, Nobuhiko; Potjans, Tobias C.; Diesmann, Markus; Sakai, Ko; Fukai, Tomoki

    2013-01-01

    Directing attention to the spatial location or the distinguishing feature of a visual object modulates neuronal responses in the visual cortex and the stimulus discriminability of subjects. However, the spatial and feature-based modes of attention differently influence visual processing by changing the tuning properties of neurons. Intriguingly, neurons' tuning curves are modulated similarly across different visual areas under both these modes of attention. Here, we explored the mechanism underlying the effects of these two modes of visual attention on the orientation selectivity of visual cortical neurons. To do this, we developed a layered microcircuit model. This model describes multiple orientation-specific microcircuits sharing their receptive fields and consisting of layers 2/3, 4, 5, and 6. These microcircuits represent a functional grouping of cortical neurons and mutually interact via lateral inhibition and excitatory connections between groups with similar selectivity. The individual microcircuits receive bottom-up visual stimuli and top-down attention in different layers. A crucial assumption of the model is that feature-based attention activates orientation-specific microcircuits for the relevant feature selectively, whereas spatial attention activates all microcircuits homogeneously, irrespective of their orientation selectivity. Consequently, our model simultaneously accounts for the multiplicative scaling of neuronal responses in spatial attention and the additive modulations of orientation tuning curves in feature-based attention, which have been observed widely in various visual cortical areas. Simulations of the model predict contrasting differences between excitatory and inhibitory neurons in the two modes of attentional modulations. Furthermore, the model replicates the modulation of the psychophysical discriminability of visual stimuli in the presence of external noise. Our layered model with a biologically suggested laminar structure describes the basic circuit mechanism underlying the attention-mode specific modulations of neuronal responses and visual perception. PMID:24324628

  14. Water resources by orbital remote sensing: Examples of applications

    NASA Technical Reports Server (NTRS)

    Martini, P. R. (Principal Investigator)

    1984-01-01

    Selected applications of orbital remote sensing to water resources undertaken by INPE are described. General specifications of Earth application satellites and technical characteristics of LANDSAT 1, 2, 3, and 4 subsystems are described. Spatial, temporal and spectral image attributes of water as well as methods of image analysis for applications to water resources are discussed. Selected examples are referred to flood monitoring, analysis of water suspended sediments, spatial distribution of pollutants, inventory of surface water bodies and mapping of alluvial aquifers.

  15. There was movement that was stationary, for the four-velocity had passed around

    NASA Astrophysics Data System (ADS)

    Roukema, Boudewijn F.

    2010-05-01

    Is the Doppler interpretation of galaxy redshifts in a Friedmann-Lemaître-Robertson-Walker (FLRW) model valid in the context of the approach to comoving spatial sections pioneered by de Sitter, Friedmann, Lemaître and Robertson, i.e. according to which the three-manifold of comoving space is characterized by both its curvature and topology? Holonomy transformations for flat, spherical and hyperbolic FLRW spatial sections are proposed. By quotienting a simply connected FLRW spatial section by an appropriate group of holonomy transformations, the Doppler interpretation in a non-expanding Minkowski space-time, obtained via four-velocity parallel transport along a photon path, is found to imply that an inertial observer is receding from herself at a speed greater than zero, implying contradictory world lines. The contradiction in the multiply connected case occurs for arbitrary redshifts in the flat and spherical cases, and for certain large redshifts in the hyperbolic case. The link between the Doppler interpretation of redshifts and cosmic topology can be understood physically as the link between parallel transport along a photon path and the fact that the comoving spatial geodesic corresponding to a photon's path can be a closed loop in an FLRW model of any curvature. Closed comoving spatial loops are fundamental to cosmic topology. With apologies to Andrew Barton `Banjo' Paterson. E-mail: boud@astro.uni.torun.pl

  16. An Environmental Decision Support System for Spatial Assessment and Selective Remediation

    EPA Science Inventory

    Spatial Analysis and Decision Assistance (SADA) is a Windows freeware program that incorporates environmental assessment tools for effective problem-solving. The software integrates modules for GIS, visualization, geospatial analysis, statistical analysis, human health and ecolog...

  17. Components of working memory and visual selective attention.

    PubMed

    Burnham, Bryan R; Sabia, Matthew; Langan, Catherine

    2014-02-01

    Load theory (Lavie, N., Hirst, A., De Fockert, J. W., & Viding, E. [2004]. Load theory of selective attention and cognitive control. Journal of Experimental Psychology: General, 133, 339-354.) proposes that control of attention depends on the amount and type of load that is imposed by current processing. Specifically, perceptual load should lead to efficient distractor rejection, whereas working memory load (dual-task coordination) should hinder distractor rejection. Studies support load theory's prediction that working memory load will lead to larger distractor effects; however, these studies used secondary tasks that required only verbal working memory and the central executive. The present study examined which other working memory components (visual, spatial, and phonological) influence visual selective attention. Subjects completed an attentional capture task alone (single-task) or while engaged in a working memory task (dual-task). Results showed that along with the central executive, visual and spatial working memory influenced selective attention, but phonological working memory did not. Specifically, attentional capture was larger when visual or spatial working memory was loaded, but phonological working memory load did not affect attentional capture. The results are consistent with load theory and suggest specific components of working memory influence visual selective attention. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  18. Relationships Among Peripheral and Central Electrophysiological Measures of Spatial and Spectral Selectivity and Speech Perception in Cochlear Implant Users.

    PubMed

    Scheperle, Rachel A; Abbas, Paul J

    2015-01-01

    The ability to perceive speech is related to the listener's ability to differentiate among frequencies (i.e., spectral resolution). Cochlear implant (CI) users exhibit variable speech-perception and spectral-resolution abilities, which can be attributed in part to the extent of electrode interactions at the periphery (i.e., spatial selectivity). However, electrophysiological measures of peripheral spatial selectivity have not been found to correlate with speech perception. The purpose of this study was to evaluate auditory processing at the periphery and cortex using both simple and spectrally complex stimuli to better understand the stages of neural processing underlying speech perception. The hypotheses were that (1) by more completely characterizing peripheral excitation patterns than in previous studies, significant correlations with measures of spectral selectivity and speech perception would be observed, (2) adding information about processing at a level central to the auditory nerve would account for additional variability in speech perception, and (3) responses elicited with spectrally complex stimuli would be more strongly correlated with speech perception than responses elicited with spectrally simple stimuli. Eleven adult CI users participated. Three experimental processor programs (MAPs) were created to vary the likelihood of electrode interactions within each participant. For each MAP, a subset of 7 of 22 intracochlear electrodes was activated: adjacent (MAP 1), every other (MAP 2), or every third (MAP 3). Peripheral spatial selectivity was assessed using the electrically evoked compound action potential (ECAP) to obtain channel-interaction functions for all activated electrodes (13 functions total). Central processing was assessed by eliciting the auditory change complex with both spatial (electrode pairs) and spectral (rippled noise) stimulus changes. Speech-perception measures included vowel discrimination and the Bamford-Kowal-Bench Speech-in-Noise test. Spatial and spectral selectivity and speech perception were expected to be poorest with MAP 1 (closest electrode spacing) and best with MAP 3 (widest electrode spacing). Relationships among the electrophysiological and speech-perception measures were evaluated using mixed-model and simple linear regression analyses. All electrophysiological measures were significantly correlated with each other and with speech scores for the mixed-model analysis, which takes into account multiple measures per person (i.e., experimental MAPs). The ECAP measures were the best predictor. In the simple linear regression analysis on MAP 3 data, only the cortical measures were significantly correlated with speech scores; spectral auditory change complex amplitude was the strongest predictor. The results suggest that both peripheral and central electrophysiological measures of spatial and spectral selectivity provide valuable information about speech perception. Clinically, it is often desirable to optimize performance for individual CI users. These results suggest that ECAP measures may be most useful for within-subject applications when multiple measures are performed to make decisions about processor options. They also suggest that if the goal is to compare performance across individuals based on a single measure, then processing central to the auditory nerve (specifically, cortical measures of discriminability) should be considered.

  19. Adaptive web sampling.

    PubMed

    Thompson, Steven K

    2006-12-01

    A flexible class of adaptive sampling designs is introduced for sampling in network and spatial settings. In the designs, selections are made sequentially with a mixture distribution based on an active set that changes as the sampling progresses, using network or spatial relationships as well as sample values. The new designs have certain advantages compared with previously existing adaptive and link-tracing designs, including control over sample sizes and of the proportion of effort allocated to adaptive selections. Efficient inference involves averaging over sample paths consistent with the minimal sufficient statistic. A Markov chain resampling method makes the inference computationally feasible. The designs are evaluated in network and spatial settings using two empirical populations: a hidden human population at high risk for HIV/AIDS and an unevenly distributed bird population.

  20. Considering Spatial Scale and Reproductive Consequences of Habitat Selection when Managing Grasslands for a Threatened Species

    PubMed Central

    Pearson, Scott F.; Knapp, Shannon M.

    2016-01-01

    Habitat selection that has fitness consequences has important implications for conservation activities. For example, habitat characteristics that influence nest success in birds can be manipulated to improve habitat quality with the goal of ultimately improving reproductive success. We examined habitat selection by the threatened streaked horned lark (Eremophila alpestris strigata) at both the breeding-site (territory) and nest-site scales. Larks were selective at both spatial scales but with contrasting selection. At the territory scale, male larks selected sparsely vegetated grasslands with relatively short vegetation. At the nest-site scale, female larks selected sites within territories with higher vegetation density and more perennial forbs. These nest-site scale choices had reproductive consequences, with greater nest success in areas with higher densities of perennial forbs. We experimentally manipulated lark habitat structure in an attempt to mimic the habitat conditions selected by larks by using late summer prescribed fires. After the burn, changes in vegetation structure were in the direction preferred by larks but habitat effects attenuated by the following year. Our results highlight the importance of evaluating habitat selection at spatial scales appropriate to the species of interest, especially when attempting to improve habitat quality for rare and declining species. They also highlight the importance of conducting restoration activities in a research context. For example, because the sparsely vegetated conditions created by fire attenuate, there may be value in examining more frequent burns or hotter fires as the next management and research action. We hope the design outlined in this study will serve as an integrated research and management example for conserving grassland birds generally. PMID:27322196

  1. Measuring high-density built environment for public health research: Uncertainty with respect to data, indicator design and spatial scale.

    PubMed

    Sun, Guibo; Webster, Chris; Ni, Michael Y; Zhang, Xiaohu

    2018-05-07

    Uncertainty with respect to built environment (BE) data collection, measure conceptualization and spatial scales is evident in urban health research, but most findings are from relatively lowdensity contexts. We selected Hong Kong, an iconic high-density city, as the study area as limited research has been conducted on uncertainty in such areas. We used geocoded home addresses (n=5732) from a large population-based cohort in Hong Kong to extract BE measures for the participants' place of residence based on an internationally recognized BE framework. Variability of the measures was mapped and Spearman's rank correlation calculated to assess how well the relationships among indicators are preserved across variables and spatial scales. We found extreme variations and uncertainties for the 180 measures collected using comprehensive data and advanced geographic information systems modelling techniques. We highlight the implications of methodological selection and spatial scales of the measures. The results suggest that more robust information regarding urban health research in high-density city would emerge if greater consideration were given to BE data, design methods and spatial scales of the BE measures.

  2. A compilation of spatial digital databases for selected U.S. Geological Survey nonfuel mineral resource assessments for parts of Idaho and Montana

    USGS Publications Warehouse

    Carlson, Mary H.; Zientek, Michael L.; Causey, J. Douglas; Kayser, Helen Z.; Spanski, Gregory T.; Wilson, Anna B.; Van Gosen, Bradley S.; Trautwein, Charles M.

    2007-01-01

    This report compiles selected results from 13 U.S. Geological Survey (USGS) mineral resource assessment studies conducted in Idaho and Montana into consistent spatial databases that can be used in a geographic information system. The 183 spatial databases represent areas of mineral potential delineated in these studies and include attributes on mineral deposit type, level of mineral potential, certainty, and a reference. The assessments were conducted for five 1? x 2? quadrangles (Butte, Challis, Choteau, Dillon, and Wallace), several U.S. Forest Service (USFS) National Forests (including Challis, Custer, Gallatin, Helena, and Payette), and one Bureau of Land Management (BLM) Resource Area (Dillon). The data contained in the spatial databases are based on published information: no new interpretations are made. This digital compilation is part of an ongoing effort to provide mineral resource information formatted for use in spatial analysis. In particular, this is one of several reports prepared to address USFS needs for science information as forest management plans are revised in the Northern Rocky Mountains.

  3. On the importance of balancing selection in plants

    PubMed Central

    Delph, Lynda F.; Kelly, John K.

    2013-01-01

    Summary Balancing selection refers to a variety of selective regimes that maintain advantageous genetic diversity within populations. We review the history of the ideas regarding the types of selection that maintain such polymorphism in flowering plants, notably heterozygote advantage, negative frequency-dependent selection, and spatial heterogeneity. One shared feature of these mechanisms is that whether an allele is beneficial or detrimental is conditional on its frequency in the population. We highlight examples of balancing selection on a variety of discrete traits. These include the well-referenced case of self-incompatibility and recent evidence from species with nuclear-cytoplasmic gynodioecy, both of which exhibit trans-specific polymorphism, a hallmark of balancing selection. We also discuss and give examples of how spatial heterogeneity in particular, which is often thought unlikely to allow protected polymorphism, can maintain genetic variation in plants (which are rooted in place) as a result of microhabitat selection. Lastly, we discuss limitations of the protected polymorphism concept for quantitative traits, where selection can inflate the genetic variance without maintaining specific alleles indefinitely. We conclude that while discrete-morph variation provides the most unambiguous cases of protected polymorphism, they represent only a fraction of the balancing selection at work in plants. PMID:23952298

  4. Statistics of natural scenes and cortical color processing.

    PubMed

    Cecchi, Guillermo A; Rao, A Ravishankar; Xiao, Youping; Kaplan, Ehud

    2010-09-01

    We investigate the spatial correlations of orientation and color information in natural images. We find that the correlation of orientation information falls off rapidly with increasing distance, while color information is more highly correlated over longer distances. We show that orientation and color information are statistically independent in natural images and that the spatial correlation of jointly encoded orientation and color information decays faster than that of color alone. Our findings suggest that: (a) orientation and color information should be processed in separate channels and (b) the organization of cortical color and orientation selectivity at low spatial frequencies is a reflection of the cortical adaptation to the statistical structure of the visual world. These findings are in agreement with biological observations, as form and color are thought to be represented by different classes of neurons in the primary visual cortex, and the receptive fields of color-selective neurons are larger than those of orientation-selective neurons. The agreement between our findings and biological observations supports the ecological theory of perception.

  5. Image Discrimination Models With Stochastic Channel Selection

    NASA Technical Reports Server (NTRS)

    Ahumada, Albert J., Jr.; Beard, Bettina L.; Null, Cynthia H. (Technical Monitor)

    1995-01-01

    Many models of human image processing feature a large fixed number of channels representing cortical units varying in spatial position (visual field direction and eccentricity) and spatial frequency (radial frequency and orientation). The values of these parameters are usually sampled at fixed values selected to ensure adequate overlap considering the bandwidth and/or spread parameters, which are usually fixed. Even high levels of overlap does not always ensure that the performance of the model will vary smoothly with image translation or scale changes. Physiological measurements of bandwidth and/or spread parameters result in a broad distribution of estimated parameter values and the prediction of some psychophysical results are facilitated by the assumption that these parameters also take on a range of values. Selecting a sample of channels from a continuum of channels rather than using a fixed set can make model performance vary smoothly with changes in image position, scale, and orientation. It also facilitates the addition of spatial inhomogeneity, nonlinear feature channels, and focus of attention to channel models.

  6. Unique Fock quantization of a massive fermion field in a cosmological scenario

    NASA Astrophysics Data System (ADS)

    Cortez, Jerónimo; Elizaga Navascués, Beatriz; Martín-Benito, Mercedes; Mena Marugán, Guillermo A.; Velhinho, José M.

    2016-04-01

    It is well known that the Fock quantization of field theories in general spacetimes suffers from an infinite ambiguity, owing to the inequivalent possibilities in the selection of a representation of the canonical commutation or anticommutation relations, but also owing to the freedom in the choice of variables to describe the field among all those related by linear time-dependent transformations, including the dependence through functions of the background. In this work we remove this ambiguity (up to unitary equivalence) in the case of a massive Dirac free field propagating in a spacetime with homogeneous and isotropic spatial sections of spherical topology. Two physically reasonable conditions are imposed in order to arrive at this result: (a) The invariance of the vacuum under the spatial isometries of the background, and (b) the unitary implementability of the dynamical evolution that dictates the Dirac equation. We characterize the Fock quantizations with a nontrivial fermion dynamics that satisfy these two conditions. Then, we provide a complete proof of the unitary equivalence of the representations in this class under very mild requirements on the time variation of the background, once a criterion to discern between particles and antiparticles has been set.

  7. NMDA Signaling in CA1 Mediates Selectively the Spatial Component of Episodic Memory

    ERIC Educational Resources Information Center

    Place, Ryan; Lykken, Christy; Beer, Zachery; Suh, Junghyup; McHugh, Thomas J.; Tonegawa, Susumu; Eichenbaum, Howard; Sauvage, Magdalena M.

    2012-01-01

    Recent studies focusing on the memory for temporal order have reported that CA1 plays a critical role in the memory for the sequences of events, in addition to its well-described role in spatial navigation. In contrast, CA3 was found to principally contribute to the memory for the association of items with spatial or contextual information in…

  8. Development and Validation of Spatially Explicit Habitat Models for Cavity-nesting Birds in Fishlake National Forest, Utah

    Treesearch

    Randall A., Jr. Schultz; Thomas C., Jr. Edwards; Gretchen G. Moisen; Tracey S. Frescino

    2005-01-01

    The ability of USDA Forest Service Forest Inventory and Analysis (FIA) generated spatial products to increase the predictive accuracy of spatially explicit, macroscale habitat models was examined for nest-site selection by cavity-nesting birds in Fishlake National Forest, Utah. One FIA-derived variable (percent basal area of aspen trees) was significant in the habitat...

  9. Real-time 2D spatially selective MRI experiments: Comparative analysis of optimal control design methods.

    PubMed

    Maximov, Ivan I; Vinding, Mads S; Tse, Desmond H Y; Nielsen, Niels Chr; Shah, N Jon

    2015-05-01

    There is an increasing need for development of advanced radio-frequency (RF) pulse techniques in modern magnetic resonance imaging (MRI) systems driven by recent advancements in ultra-high magnetic field systems, new parallel transmit/receive coil designs, and accessible powerful computational facilities. 2D spatially selective RF pulses are an example of advanced pulses that have many applications of clinical relevance, e.g., reduced field of view imaging, and MR spectroscopy. The 2D spatially selective RF pulses are mostly generated and optimised with numerical methods that can handle vast controls and multiple constraints. With this study we aim at demonstrating that numerical, optimal control (OC) algorithms are efficient for the design of 2D spatially selective MRI experiments, when robustness towards e.g. field inhomogeneity is in focus. We have chosen three popular OC algorithms; two which are gradient-based, concurrent methods using first- and second-order derivatives, respectively; and a third that belongs to the sequential, monotonically convergent family. We used two experimental models: a water phantom, and an in vivo human head. Taking into consideration the challenging experimental setup, our analysis suggests the use of the sequential, monotonic approach and the second-order gradient-based approach as computational speed, experimental robustness, and image quality is key. All algorithms used in this work were implemented in the MATLAB environment and are freely available to the MRI community. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Mapping feature-sensitivity and attentional modulation in human auditory cortex with functional magnetic resonance imaging

    PubMed Central

    Paltoglou, Aspasia E; Sumner, Christian J; Hall, Deborah A

    2011-01-01

    Feature-specific enhancement refers to the process by which selectively attending to a particular stimulus feature specifically increases the response in the same region of the brain that codes that stimulus property. Whereas there are many demonstrations of this mechanism in the visual system, the evidence is less clear in the auditory system. The present functional magnetic resonance imaging (fMRI) study examined this process for two complex sound features, namely frequency modulation (FM) and spatial motion. The experimental design enabled us to investigate whether selectively attending to FM and spatial motion enhanced activity in those auditory cortical areas that were sensitive to the two features. To control for attentional effort, the difficulty of the target-detection tasks was matched as closely as possible within listeners. Locations of FM-related and motion-related activation were broadly compatible with previous research. The results also confirmed a general enhancement across the auditory cortex when either feature was being attended to, as compared with passive listening. The feature-specific effects of selective attention revealed the novel finding of enhancement for the nonspatial (FM) feature, but not for the spatial (motion) feature. However, attention to spatial features also recruited several areas outside the auditory cortex. Further analyses led us to conclude that feature-specific effects of selective attention are not statistically robust, and appear to be sensitive to the choice of fMRI experimental design and localizer contrast. PMID:21447093

  11. Genetic patterns of habitat fragmentation and past climate-change effects in the Mediterranean high-mountain plant Armeria caespitosa (Plumbaginaceae).

    PubMed

    García-Fernández, Alfredo; Iriondo, Jose M; Escudero, Adrián; Aguilar, Javier Fuertes; Feliner, Gonzalo Nieto

    2013-08-01

    Mountain plants are among the species most vulnerable to global warming, because of their isolation, narrow geographic distribution, and limited geographic range shifts. Stochastic and selective processes can act on the genome, modulating genetic structure and diversity. Fragmentation and historical processes also have a great influence on current genetic patterns, but the spatial and temporal contexts of these processes are poorly known. We aimed to evaluate the microevolutionary processes that may have taken place in Mediterranean high-mountain plants in response to changing historical environmental conditions. Genetic structure, diversity, and loci under selection were analyzed using AFLP markers in 17 populations distributed over the whole geographic range of Armeria caespitosa, an endemic plant that inhabits isolated mountains (Sierra de Guadarrama, Spain). Differences in altitude, geographic location, and climate conditions were considered in the analyses, because they may play an important role in selective and stochastic processes. Bayesian clustering approaches identified nine genetic groups, although some discrepancies in assignment were found between alternative analyses. Spatially explicit analyses showed a weak relationship between genetic parameters and spatial or environmental distances. However, a large proportion of outlier loci were detected, and some outliers were related to environmental variables. A. caespitosa populations exhibit spatial patterns of genetic structure that cannot be explained by the isolation-by-distance model. Shifts along the altitude gradient in response to Pleistocene climatic oscillations and environmentally mediated selective forces might explain the resulting structure and genetic diversity values found.

  12. Spatial variation in colour morph, spotting and allozyme frequencies in the candy-stripe spider, Enoplognatha ovata (Theridiidae) on two Swedish archipelagos.

    PubMed

    Oxford, G S; Gunnarsson, B

    2006-01-01

    The selective significance, if any, of many invertebrate visible polymorphisms is still not fully understood. Here we examine colour- and black spotting-morph frequencies in the spider Enoplognatha ovata in populations on two Swedish archipelagos with respect to different spatial scales and, in one archipelago, against the background of variation at four putative neutral allozyme marker loci. Every population studied was polymorphic for colour and 28 out of 30 contained all three colour morphs--lineata, redimita and ovata. We found no evidence for a breakdown in the traditional colour morph designation previously suggested for other northern European populations of this species. For colour there is no significant heterogeneity at spatial scales greater than between local populations within islands. Black spotting frequencies show a similar lack of pattern over larger spatial scales except that there are significant differences between the Stockholm and Göteborg archipelagos. Measures of population differentiation (theta) within the Stockholm islands for the two visible systems show them to be significantly more differentiated than the neutral markers, suggesting local selection acting on them in a population-specific manner. On the basis of previous observations and the distribution of spotting phenotypes on a European scale, it is argued that thermal selection might operate on black spotting during the juvenile stages favouring more spots in continental climates. It is not clear what selective forces act on colour.

  13. The Influence of Endmember Selection Method in Extracting Impervious Surface from Airborne Hyperspectral Imagery

    NASA Astrophysics Data System (ADS)

    Wang, J.; Feng, B.

    2016-12-01

    Impervious surface area (ISA) has long been studied as an important input into moisture flux models. In general, ISA impedes groundwater recharge, increases stormflow/flood frequency, and alters in-stream and riparian habitats. Urban area is recognized as one of the richest ISA environment. Urban ISA mapping assists flood prevention and urban planning. Hyperspectral imagery (HI), for its ability to detect subtle spectral signature, becomes an ideal candidate in urban ISA mapping. To map ISA from HI involves endmember (EM) selection. The high degree of spatial and spectral heterogeneity of urban environment puts great difficulty in this task: a compromise point is needed between the automatic degree and the good representativeness of the method. The study tested one manual and two semi-automatic EM selection strategies. The manual and the first semi-automatic methods have been widely used in EM selection. The second semi-automatic EM selection method is rather new and has been only proposed for moderate spatial resolution satellite. The manual method visually selected the EM candidates from eight landcover types in the original image. The first semi-automatic method chose the EM candidates using a threshold over the pixel purity index (PPI) map. The second semi-automatic method used the triangle shape of the HI scatter plot in the n-Dimension visualizer to identify the V-I-S (vegetation-impervious surface-soil) EM candidates: the pixels locate at the triangle points. The initial EM candidates from the three methods were further refined by three indexes (EM average RMSE, minimum average spectral angle, and count based EM selection) and generated three spectral libraries, which were used to classify the test image. Spectral angle mapper was applied. The accuracy reports for the classification results were generated. The overall accuracy are 85% for the manual method, 81% for the PPI method, and 87% for the V-I-S method. The V-I-S EM selection method performs best in this study. This fact proves the value of V-I-S EM selection method in not only moderate spatial resolution satellite image but also the more and more accessible high spatial resolution airborne image. This semi-automatic EM selection method can be adopted into a wide range of remote sensing images and provide ISA map for hydrology analysis.

  14. Dynamic modulation of the perceptual load on microsaccades during a selective spatial attention task.

    PubMed

    Xue, Linyan; Huang, Dan; Wang, Tong; Hu, Qiyi; Chai, Xinyu; Li, Liming; Chen, Yao

    2017-11-28

    Selective spatial attention enhances task performance at restricted regions within the visual field. The magnitude of this effect depends on the level of attentional load, which determines the efficiency of distractor rejection. Mechanisms of attentional load include perceptual selection and/or cognitive control involving working memory. Recent studies have provided evidence that microsaccades are influenced by spatial attention. Therefore, microsaccade activities may be exploited to help understand the dynamic control of selective attention under different load levels. However, previous reports in humans on the effect of attentional load on microsaccades are inconsistent, and it is not clear to what extent these results and the dynamic changes of microsaccade activities are similar in monkeys. We trained monkeys to perform a color detection task in which the perceptual load was manipulated by task difficulty with limited involvement of working memory. Our results indicate that during the task with high perceptual load, the rate and amplitude of microsaccades immediately before the target color change were significantly suppressed. We also found that the occurrence of microsaccades before the monkeys' detection response deteriorated their performance, especially in the hard task. We propose that the activity of microsaccades might be an efficacious indicator of the perceptual load.

  15. Bet-hedging as a complex interaction among developmental instability, environmental heterogeneity, dispersal, and life-history strategy.

    PubMed

    Scheiner, Samuel M

    2014-02-01

    One potential evolutionary response to environmental heterogeneity is the production of randomly variable offspring through developmental instability, a type of bet-hedging. I used an individual-based, genetically explicit model to examine the evolution of developmental instability. The model considered both temporal and spatial heterogeneity alone and in combination, the effect of migration pattern (stepping stone vs. island), and life-history strategy. I confirmed that temporal heterogeneity alone requires a threshold amount of variation to select for a substantial amount of developmental instability. For spatial heterogeneity only, the response to selection on developmental instability depended on the life-history strategy and the form and pattern of dispersal with the greatest response for island migration when selection occurred before dispersal. Both spatial and temporal variation alone select for similar amounts of instability, but in combination resulted in substantially more instability than either alone. Local adaptation traded off against bet-hedging, but not in a simple linear fashion. I found higher-order interactions between life-history patterns, dispersal rates, dispersal patterns, and environmental heterogeneity that are not explainable by simple intuition. We need additional modeling efforts to understand these interactions and empirical tests that explicitly account for all of these factors.

  16. Comparison of climate envelope models developed using expert-selected variables versus statistical selection

    USGS Publications Warehouse

    Brandt, Laura A.; Benscoter, Allison; Harvey, Rebecca G.; Speroterra, Carolina; Bucklin, David N.; Romañach, Stephanie; Watling, James I.; Mazzotti, Frank J.

    2017-01-01

    Climate envelope models are widely used to describe potential future distribution of species under different climate change scenarios. It is broadly recognized that there are both strengths and limitations to using climate envelope models and that outcomes are sensitive to initial assumptions, inputs, and modeling methods Selection of predictor variables, a central step in modeling, is one of the areas where different techniques can yield varying results. Selection of climate variables to use as predictors is often done using statistical approaches that develop correlations between occurrences and climate data. These approaches have received criticism in that they rely on the statistical properties of the data rather than directly incorporating biological information about species responses to temperature and precipitation. We evaluated and compared models and prediction maps for 15 threatened or endangered species in Florida based on two variable selection techniques: expert opinion and a statistical method. We compared model performance between these two approaches for contemporary predictions, and the spatial correlation, spatial overlap and area predicted for contemporary and future climate predictions. In general, experts identified more variables as being important than the statistical method and there was low overlap in the variable sets (<40%) between the two methods Despite these differences in variable sets (expert versus statistical), models had high performance metrics (>0.9 for area under the curve (AUC) and >0.7 for true skill statistic (TSS). Spatial overlap, which compares the spatial configuration between maps constructed using the different variable selection techniques, was only moderate overall (about 60%), with a great deal of variability across species. Difference in spatial overlap was even greater under future climate projections, indicating additional divergence of model outputs from different variable selection techniques. Our work is in agreement with other studies which have found that for broad-scale species distribution modeling, using statistical methods of variable selection is a useful first step, especially when there is a need to model a large number of species or expert knowledge of the species is limited. Expert input can then be used to refine models that seem unrealistic or for species that experts believe are particularly sensitive to change. It also emphasizes the importance of using multiple models to reduce uncertainty and improve map outputs for conservation planning. Where outputs overlap or show the same direction of change there is greater certainty in the predictions. Areas of disagreement can be used for learning by asking why the models do not agree, and may highlight areas where additional on-the-ground data collection could improve the models.

  17. Pfhrp2-Deleted Plasmodium falciparum Parasites in the Democratic Republic of the Congo: A National Cross-sectional Survey.

    PubMed

    Parr, Jonathan B; Verity, Robert; Doctor, Stephanie M; Janko, Mark; Carey-Ewend, Kelly; Turman, Breanna J; Keeler, Corinna; Slater, Hannah C; Whitesell, Amy N; Mwandagalirwa, Kashamuka; Ghani, Azra C; Likwela, Joris L; Tshefu, Antoinette K; Emch, Michael; Juliano, Jonathan J; Meshnick, Steven R

    2017-07-01

    Rapid diagnostic tests (RDTs) account for more than two-thirds of malaria diagnoses in Africa. Deletions of the Plasmodium falciparum hrp2 (pfhrp2) gene cause false-negative RDT results and have never been investigated on a national level. Spread of pfhrp2-deleted P. falciparum mutants, resistant to detection by HRP2-based RDTs, would represent a serious threat to malaria elimination efforts. Using a nationally representative cross-sectional study of 7,137 children under five years of age from the Democratic Republic of Congo (DRC), we tested 783 subjects with RDT-/PCR+ results using PCR assays to detect and confirm deletions of the pfhrp2 gene. Spatial and population genetic analyses were employed to examine the distribution and evolution of these parasites. We identified 149 pfhrp2-deleted parasites, representing 6.4% of all P. falciparum infections country-wide (95% confidence interval 5.1-8.0%). Bayesian spatial analyses identified statistically significant clustering of pfhrp2 deletions near Kinshasa and Kivu. Population genetic analysis revealed significant genetic differentiation between wild-type and pfhrp2-deleted parasite populations (GST = .046, p ≤ .00001). Pfhrp2-deleted P. falciparum is a common cause of RDT-/PCR+ malaria among asymptomatic children in the DRC and appears to be clustered within select communities. Surveillance for these deletions is needed, and alternatives to HRP2-specific RDTs may be necessary. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  18. Absolute optical extinction measurements of single nano-objects by spatial modulation spectroscopy using a white lamp

    NASA Astrophysics Data System (ADS)

    Billaud, Pierre; Marhaba, Salem; Grillet, Nadia; Cottancin, Emmanuel; Bonnet, Christophe; Lermé, Jean; Vialle, Jean-Louis; Broyer, Michel; Pellarin, Michel

    2010-04-01

    This article describes a high sensitivity spectrophotometer designed to detect the overall extinction of light by a single nanoparticle (NP) in the 10-4-10-5 relative range, using a transmission measurement configuration. We focus here on the simple and low cost scheme where a white lamp is used as a light source, permitting easy and broadband extinction measurements (300-900 nm). Using a microscope, in a confocal geometry, an increased sensitivity is reached thanks to a modulation of the NP position under the light spot combined with lock-in detection. Moreover, it is shown that this technique gives access to the absolute extinction cross-sections of the single NP provided that the incident electromagnetic field distribution experienced by the NP is accurately characterized. In this respect, an experimental procedure to characterize the light spot profile in the focal plane, using a reference NP as a probe, is also laid out. The validity of this approach is discussed and confirmed by comparing experimental intensity distributions to theoretical calculations taking into account the vector character of the tightly focused beam. The calibration procedure permitting to obtain the absolute extinction cross-section of the probed NP is then fully described. Finally, the force of the present technique is illustrated through selected examples concerning spherical and slightly elongated gold and silver NPs. Absolute extinction measurements are found to be in good consistency with the NP size and shape independently obtained from transmission electron microscopy, showing that spatial modulation spectroscopy is a powerful tool to get an optical fingerprint of the NP.

  19. BENZODIAZEPINE-INDUCED SPATIAL LEARNING DEFICITS IN RATS ARE REGULATED BY THE DEGREE OF MODULATION OF α1 GABAA RECEPTORS

    PubMed Central

    Joksimović, Srđan; Divljaković, Jovana; Van Linn, Michael L.; Varagic, Zdravko; Brajković, Gordana; Milinković, Marija M.; Yin, Wenyuan; Timić, Tamara; Sieghart, Werner; Cook, James M.; Savić, Miroslav M.

    2012-01-01

    Despite significant advances in understanding the role of benzodiazepine (BZ)-sensitive populations of GABAA receptors, containing the α1, α2, α3 or α5 subunit, factual substrates of BZ-induced learning and memory deficits are not yet fully elucidated. It was shown that α1-subunit affinity-selective antagonist β-CCt almost completely abolished spatial learning deficits induced by diazepam (DZP) in the Morris water maze. We examined a novel, highly (105 fold) α1-subunit selective ligand - WYS8 (0.2, 1 and 10 mg/kg), on its own and in combination with the non-selective agonist DZP (2 mg/kg) or β-CCt (5 mg/kg) in the water maze in rats. The in vitro efficacy study revealed that WYS8 acts as α1-subtype selective weak partial positive modulator (40% potentiation at 100 nM). Measurement of concentrations of WYS8 and DZP in rat serum and brain tissues suggested that they did not substantially cross-influence the respective disposition. In the water maze, DZP impaired spatial learning (acquisition trials) and memory (probe trial). WYS8 caused no effect per se, did not affect the overall influence of DZP on the water-maze performance and was devoid of any activity in this task when combined with β-CCt. Nonetheless, an additional analysis of the latency to reach the platform and the total distance swam suggested that WYS8 addition attenuated the run-down of the spatial impairment induced by DZP at the end of acquisition trials. These results demonstrate a clear difference in the influence of an α1 subtype-selective antagonist and a partial agonist on the effects of DZP on the water-maze acquisition. PMID:22633616

  20. Effect of spatial filtering on crosstalk reduction in surface EMG recordings.

    PubMed

    Mesin, Luca; Smith, Stuart; Hugo, Suzanne; Viljoen, Suretha; Hanekom, Tania

    2009-04-01

    Increasing the selectivity of the detection system in surface electromyography (EMG) is beneficial in the collection of information of a specific portion of the investigated muscle and to reduce the contribution of undesired components, such as non-propagating components (due to generation or end-of-fibre effects) or crosstalk from nearby muscles. A comparison of the ability of different spatial filters to reduce the amount of crosstalk in surface EMG measurements was conducted in this paper using simulated signals. It focused on the influence of different properties of the muscle anatomy (changing subcutaneous layer thickness, skin conductivity, fibre length) and detection system (single, double and normal double differential, with two inter-electrode distances - IED) on the amount of crosstalk present in the measurements. A cylindrical multilayer (skin, subcutaneous tissue, muscle, bone) analytical model was used to simulate single fibre action potentials (SFAPs). Fibres were grouped together in motor units (MUs) and motor unit action potentials (MUAPs) were obtained by adding the SFAPs of the corresponding fibres. Interference surface EMG signals were obtained, modelling the recruitment of MUs and rate coding. The average rectified value (ARV) and mean frequency (MNF) content of the EMG signals were studied and used as a basis for determining the selectivity of each spatial filter. From these results it was found that the selectivity of each spatial filter varies depending on the transversal location of the measurement electrodes and on the anatomy. An increase in skin conductivity favourably affects the selectivity of normal double differential filters as does an increase in subcutaneous layer thickness. An increase in IED decreases the selectivity of all the analysed filters.

  1. Detecting Selection on Temporal and Spatial Scales: A Genomic Time-Series Assessment of Selective Responses to Devil Facial Tumor Disease

    PubMed Central

    Brüniche-Olsen, Anna; Austin, Jeremy J.; Jones, Menna E.; Holland, Barbara R.; Burridge, Christopher P.

    2016-01-01

    Detecting loci under selection is an important task in evolutionary biology. In conservation genetics detecting selection is key to investigating adaptation to the spread of infectious disease. Loci under selection can be detected on a spatial scale, accounting for differences in demographic history among populations, or on a temporal scale, tracing changes in allele frequencies over time. Here we use these two approaches to investigate selective responses to the spread of an infectious cancer—devil facial tumor disease (DFTD)—that since 1996 has ravaged the Tasmanian devil (Sarcophilus harrisii). Using time-series ‘restriction site associated DNA’ (RAD) markers from populations pre- and post DFTD arrival, and DFTD free populations, we infer loci under selection due to DFTD and investigate signatures of selection that are incongruent among methods, populations, and times. The lack of congruence among populations influenced by DFTD with respect to inferred loci under selection, and the direction of that selection, fail to implicate a consistent selective role for DFTD. Instead genetic drift is more likely driving the observed allele frequency changes over time. Our study illustrates the importance of applying methods with different performance optima e.g. accounting for population structure and background selection, and assessing congruence of the results. PMID:26930198

  2. Multilevel processes and cultural adaptation: Examples from past and present small-scale societies.

    PubMed

    Reyes-García, V; Balbo, A L; Gomez-Baggethun, E; Gueze, M; Mesoudi, A; Richerson, P; Rubio-Campillo, X; Ruiz-Mallén, I; Shennan, S

    2016-12-01

    Cultural adaptation has become central in the context of accelerated global change with authors increasingly acknowledging the importance of understanding multilevel processes that operate as adaptation takes place. We explore the importance of multilevel processes in explaining cultural adaptation by describing how processes leading to cultural (mis)adaptation are linked through a complex nested hierarchy, where the lower levels combine into new units with new organizations, functions, and emergent properties or collective behaviours. After a brief review of the concept of "cultural adaptation" from the perspective of cultural evolutionary theory and resilience theory, the core of the paper is constructed around the exploration of multilevel processes occurring at the temporal, spatial, social and political scales. We do so by examining small-scale societies' case studies. In each section, we discuss the importance of the selected scale for understanding cultural adaptation and then present an example that illustrates how multilevel processes in the selected scale help explain observed patterns in the cultural adaptive process. We end the paper discussing the potential of modelling and computer simulation for studying multilevel processes in cultural adaptation.

  3. Multilevel processes and cultural adaptation: Examples from past and present small-scale societies

    PubMed Central

    Reyes-García, V.; Balbo, A. L.; Gomez-Baggethun, E.; Gueze, M.; Mesoudi, A.; Richerson, P.; Rubio-Campillo, X.; Ruiz-Mallén, I.; Shennan, S.

    2016-01-01

    Cultural adaptation has become central in the context of accelerated global change with authors increasingly acknowledging the importance of understanding multilevel processes that operate as adaptation takes place. We explore the importance of multilevel processes in explaining cultural adaptation by describing how processes leading to cultural (mis)adaptation are linked through a complex nested hierarchy, where the lower levels combine into new units with new organizations, functions, and emergent properties or collective behaviours. After a brief review of the concept of “cultural adaptation” from the perspective of cultural evolutionary theory and resilience theory, the core of the paper is constructed around the exploration of multilevel processes occurring at the temporal, spatial, social and political scales. We do so by examining small-scale societies’ case studies. In each section, we discuss the importance of the selected scale for understanding cultural adaptation and then present an example that illustrates how multilevel processes in the selected scale help explain observed patterns in the cultural adaptive process. We end the paper discussing the potential of modelling and computer simulation for studying multilevel processes in cultural adaptation. PMID:27774109

  4. Large Uptake of Titania and Iron Oxide Nanoparticles in the Nucleus of Lung Epithelial Cells as Measured by Raman Imaging and Multivariate Classification

    PubMed Central

    Ahlinder, Linnea; Ekstrand-Hammarström, Barbro; Geladi, Paul; Österlund, Lars

    2013-01-01

    It is a challenging task to characterize the biodistribution of nanoparticles in cells and tissue on a subcellular level. Conventional methods to study the interaction of nanoparticles with living cells rely on labeling techniques that either selectively stain the particles or selectively tag them with tracer molecules. In this work, Raman imaging, a label-free technique that requires no extensive sample preparation, was combined with multivariate classification to quantify the spatial distribution of oxide nanoparticles inside living lung epithelial cells (A549). Cells were exposed to TiO2 (titania) and/or α-FeO(OH) (goethite) nanoparticles at various incubation times (4 or 48 h). Using multivariate classification of hyperspectral Raman data with partial least-squares discriminant analysis, we show that a surprisingly large fraction of spectra, classified as belonging to the cell nucleus, show Raman bands associated with nanoparticles. Up to 40% of spectra from the cell nucleus show Raman bands associated with nanoparticles. Complementary transmission electron microscopy data for thin cell sections qualitatively support the conclusions. PMID:23870252

  5. Prefrontal spatial working memory network predicts animal's decision making in a free choice saccade task

    PubMed Central

    Mochizuki, Kei

    2015-01-01

    While neurons in the lateral prefrontal cortex (PFC) encode spatial information during the performance of working memory tasks, they are also known to participate in subjective behavior such as spatial attention and action selection. In the present study, we analyzed the activity of primate PFC neurons during the performance of a free choice memory-guided saccade task in which the monkeys needed to choose a saccade direction by themselves. In trials when the receptive field location was subsequently chosen by the animal, PFC neurons with spatially selective visual response started to show greater activation before cue onset. This result suggests that the fluctuation of firing before cue presentation prematurely biased the representation of a certain spatial location and eventually encouraged the subsequent choice of that location. In addition, modulation of the activity by the animal's choice was observed only in neurons with high sustainability of activation and was also dependent on the spatial configuration of the visual cues. These findings were consistent with known characteristics of PFC neurons in information maintenance in spatial working memory function. These results suggest that precue fluctuation of spatial representation was shared and enhanced through the working memory network in the PFC and could finally influence the animal's free choice of saccade direction. The present study revealed that the PFC plays an important role in decision making in a free choice condition and that the dynamics of decision making are constrained by the network architecture embedded in this cortical area. PMID:26490287

  6. Instanton tunneling for de Sitter space with real projective spatial sections

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ong, Yen Chin; Yeom, Dong-han, E-mail: ongyenchin@sjtu.edu.cn, E-mail: innocent.yeom@gmail.com

    The physics of tunneling from one spacetime to another is often understood in terms of instantons. For some instantons, it was recently shown in the literature that there are two complementary ''interpretations'' for their analytic continuations. Dubbed ''something-to-something'' and ''nothing-to-something'' interpretations, respectively, the former involves situation in which the initial and final hypersurfaces are connected by a Euclidean manifold, whereas the initial and final hypersurfaces in the latter case are not connected in such a way. We consider a de Sitter space with real projective space RP{sup 3} spatial sections, as was originally understood by de Sitter himself. This originalmore » version of de Sitter space has several advantages over the usual de Sitter space with S{sup 3} spatial sections. In particular, the interpretation of the de Sitter entropy as entanglement entropy is much more natural. We discuss the subtleties involved in the tunneling of such a de Sitter space.« less

  7. Apollo 9 multiband photography experiment S065

    NASA Technical Reports Server (NTRS)

    Schowengerdt, R. A.; Slater, P. N.

    1972-01-01

    Fourier analysis was applied to microdensitometer scans of a selected region of one SO65 frame in each of the three black-and-white bands. The approach was unique because a somewhat arbitrary section of the image was used and not limited to available targets as in edge analysis. Comparison of duplicates and calculation of absolute SO65 MTF were done by applying linear systems theory to the spatial spectra of the image scans. It was found that the duplication process was nonlinear and resulted in general amplification of spatial frequency modulation. However, the increase in modulation was offset by a corresponding increase in the granularity of the copies. The amount of increase seemed to be related to the initial granularity, but a direct relationship was not verified. Band-to-band comparison of image quality was achieved in the form of signal-to-noise ratio curves as a function of spatial frequency for each band. From this standpoint the DD band was an order of magnitude better than the other two. These were several factors that restricted the analysis of the Apollo 9 imagery. Among these were the lack of precise sensitometric and optical system data on the high altitude photography. In addition it was determined that there was only one simultaneous pair of high altitude and SO65 frames. Finally, the original SO65 photography was not available for scanning (for obvious reasons), thus eliminating a reference base for granularity and SO65 MTF determination.

  8. Thermocapillary Technique for Shaping and Fabricating Optical Ribbon Waveguides

    NASA Astrophysics Data System (ADS)

    Fiedler, Kevin; Troian, Sandra

    The demand for ever increasing bandwidth and higher speed communication has ushered the next generation optoelectronic integrated circuits which directly incorporate polymer optical waveguide devices. Polymer melts are very versatile materials which have been successfully cast into planar single- and multimode waveguides using techniques such as embossing, photolithography and direct laser writing. In this talk, we describe a novel thermocapillary patterning method for fabricating waveguides in which the free surface of an ultrathin molten polymer film is exposed to a spatially inhomogeneous temperature field via thermal conduction from a nearby cooled mask pattern held in close proximity. The ensuring surface temperature distribution is purposely designed to pool liquid selectively into ribbon shapes suitable for optical waveguiding, but with rounded and not rectangular cross sectional areas due to capillary forces. The solidified waveguide patterns which result from this non-contact one step procedure exhibit ultrasmooth interfaces suitable for demanding optoelectronic applications. To complement these studies, we have also conducted finite element simulations for quantifying the influence of non-rectangular cross-sectional shapes on mode propagation and losses. Kf gratefully acknowledges support from a NASA Space Technology Research Fellowship.

  9. A Review of Mid-Infrared and Near-Infrared Imaging: Principles, Concepts and Applications in Plant Tissue Analysis.

    PubMed

    Türker-Kaya, Sevgi; Huck, Christian W

    2017-01-20

    Plant cells, tissues and organs are composed of various biomolecules arranged as structurally diverse units, which represent heterogeneity at microscopic levels. Molecular knowledge about those constituents with their localization in such complexity is very crucial for both basic and applied plant sciences. In this context, infrared imaging techniques have advantages over conventional methods to investigate heterogeneous plant structures in providing quantitative and qualitative analyses with spatial distribution of the components. Thus, particularly, with the use of proper analytical approaches and sampling methods, these technologies offer significant information for the studies on plant classification, physiology, ecology, genetics, pathology and other related disciplines. This review aims to present a general perspective about near-infrared and mid-infrared imaging/microspectroscopy in plant research. It is addressed to compare potentialities of these methodologies with their advantages and limitations. With regard to the organization of the document, the first section will introduce the respective underlying principles followed by instrumentation, sampling techniques, sample preparations, measurement, and an overview of spectral pre-processing and multivariate analysis. The last section will review selected applications in the literature.

  10. Soil-Transmitted Helminths in Pre-School-Aged and School-Aged Children in an Urban Slum: A Cross-Sectional Study of Prevalence, Distribution, and Associated Exposures

    PubMed Central

    Davis, Stephanie M.; Worrell, Caitlin M.; Wiegand, Ryan E.; Odero, Kennedy O.; Suchdev, Parminder S.; Ruth, Laird J.; Lopez, Gerard; Cosmas, Leonard; Neatherlin, John; Njenga, Sammy M.; Montgomery, Joel M.; Fox, LeAnne M.

    2014-01-01

    Soil-transmitted helminths (STHs) are controlled by regular mass drug administration. Current practice targets school-age children (SAC) preferentially over pre-school age children (PSAC) and treats large areas as having uniform prevalence. We assessed infection prevalence in SAC and PSAC and spatial infection heterogeneity, using a cross-sectional study in two slum villages in Kibera, Nairobi. Nairobi has low reported STH prevalence. The SAC and PSAC were randomly selected from the International Emerging Infections Program's surveillance platform. Data included residence location and three stools tested by Kato-Katz for STHs. Prevalences among 692 analyzable children were any STH: PSAC 40.5%, SAC 40.7%; Ascaris: PSAC 24.1%, SAC 22.7%; Trichuris: PSAC 24.0%, SAC 28.8%; hookworm < 0.1%. The STH infection prevalence ranged from 22% to 71% between sub-village sectors. The PSAC have similar STH prevalences to SAC and should receive deworming. Small areas can contain heterogeneous prevalences; determinants of STH infection should be characterized and slums should be assessed separately in STH mapping. PMID:25157123

  11. Monitoring and identification of spatiotemporal landscape changes in multiple remote sensing images by using a stratified conditional Latin hypercube sampling approach and geostatistical simulation.

    PubMed

    Lin, Yu-Pin; Chu, Hone-Jay; Huang, Yu-Long; Tang, Chia-Hsi; Rouhani, Shahrokh

    2011-06-01

    This study develops a stratified conditional Latin hypercube sampling (scLHS) approach for multiple, remotely sensed, normalized difference vegetation index (NDVI) images. The objective is to sample, monitor, and delineate spatiotemporal landscape changes, including spatial heterogeneity and variability, in a given area. The scLHS approach, which is based on the variance quadtree technique (VQT) and the conditional Latin hypercube sampling (cLHS) method, selects samples in order to delineate landscape changes from multiple NDVI images. The images are then mapped for calibration and validation by using sequential Gaussian simulation (SGS) with the scLHS selected samples. Spatial statistical results indicate that in terms of their statistical distribution, spatial distribution, and spatial variation, the statistics and variograms of the scLHS samples resemble those of multiple NDVI images more closely than those of cLHS and VQT samples. Moreover, the accuracy of simulated NDVI images based on SGS with scLHS samples is significantly better than that of simulated NDVI images based on SGS with cLHS samples and VQT samples, respectively. However, the proposed approach efficiently monitors the spatial characteristics of landscape changes, including the statistics, spatial variability, and heterogeneity of NDVI images. In addition, SGS with the scLHS samples effectively reproduces spatial patterns and landscape changes in multiple NDVI images.

  12. The Golden Section as Optical Limitation.

    PubMed

    Elliott, Mark A; Kelly, Joy; Friedel, Jonas; Brodsky, Jennifer; Mulcahy, Paul

    2015-01-01

    The golden section, ϕ = (1 + √5)/2 = 1.618... and its companion ϕ = 1/ϕ = ϕ -1 = 0.618..., are irrational numbers which for centuries were believed to confer aesthetic appeal. In line with the presence of golden sectioning in natural growth patterns, recent EEG recordings show an absence of coherence between brain frequencies related by the golden ratio, suggesting the potential relevance of the golden section to brain dynamics. Using Mondrian-type patterns comprising a number of paired sections in a range of five section-section areal ratios (including golden-sectioned pairs), participants were asked to indicate as rapidly and accurately as possible the polarity (light or dark) of the smallest section in the patterns. They were also asked to independently assess the aesthetic appeal of the patterns. No preference was found for golden-sectioned patterns, while reaction times (RTs) tended to decrease overall with increasing ratio independently of each pattern's fractal dimensionality. (Fractal dimensionality was unrelated to ratio and measured in terms of the Minkowski-Bouligand box-counting dimension). The ease of detecting the smallest section also decreased with increasing ratio, although RTs were found to be substantially slower for golden-sectioned patterns under 8-paired sectioned conditions. This was confirmed by a significant linear relationship between RT and ratio (p < .001) only when the golden-sectioned RTs were excluded [the relationship was non-significant for the full complement of ratios (p = .217)]. Image analysis revealed an absence of spatial frequencies between 4 and 8 cycles-per-degree that was exclusive to the 8-paired (golden)-sectioned patterns. The significance of this was demonstrated in a subsequent experiment by addition of uniformly distributed random noise to the patterns. This provided a uniform spatial-frequency profile for all patterns, which did not influence the decrease in RT with increasing ratio but abolished the elevated RTs to golden-sectioned patterns. This suggests that optical limitation in the form of reduced inter-neural synchronization during spatial-frequency coding may be the foundation for the perceptual effects of golden sectioning.

  13. Multi-scale habitat selection modeling: A review and outlook

    Treesearch

    Kevin McGarigal; Ho Yi Wan; Kathy A. Zeller; Brad C. Timm; Samuel A. Cushman

    2016-01-01

    Scale is the lens that focuses ecological relationships. Organisms select habitat at multiple hierarchical levels and at different spatial and/or temporal scales within each level. Failure to properly address scale dependence can result in incorrect inferences in multi-scale habitat selection modeling studies.

  14. Sampling in health geography: reconciling geographical objectives and probabilistic methods. An example of a health survey in Vientiane (Lao PDR)

    PubMed Central

    Vallée, Julie; Souris, Marc; Fournet, Florence; Bochaton, Audrey; Mobillion, Virginie; Peyronnie, Karine; Salem, Gérard

    2007-01-01

    Background Geographical objectives and probabilistic methods are difficult to reconcile in a unique health survey. Probabilistic methods focus on individuals to provide estimates of a variable's prevalence with a certain precision, while geographical approaches emphasise the selection of specific areas to study interactions between spatial characteristics and health outcomes. A sample selected from a small number of specific areas creates statistical challenges: the observations are not independent at the local level, and this results in poor statistical validity at the global level. Therefore, it is difficult to construct a sample that is appropriate for both geographical and probability methods. Methods We used a two-stage selection procedure with a first non-random stage of selection of clusters. Instead of randomly selecting clusters, we deliberately chose a group of clusters, which as a whole would contain all the variation in health measures in the population. As there was no health information available before the survey, we selected a priori determinants that can influence the spatial homogeneity of the health characteristics. This method yields a distribution of variables in the sample that closely resembles that in the overall population, something that cannot be guaranteed with randomly-selected clusters, especially if the number of selected clusters is small. In this way, we were able to survey specific areas while minimising design effects and maximising statistical precision. Application We applied this strategy in a health survey carried out in Vientiane, Lao People's Democratic Republic. We selected well-known health determinants with unequal spatial distribution within the city: nationality and literacy. We deliberately selected a combination of clusters whose distribution of nationality and literacy is similar to the distribution in the general population. Conclusion This paper describes the conceptual reasoning behind the construction of the survey sample and shows that it can be advantageous to choose clusters using reasoned hypotheses, based on both probability and geographical approaches, in contrast to a conventional, random cluster selection strategy. PMID:17543100

  15. Sampling in health geography: reconciling geographical objectives and probabilistic methods. An example of a health survey in Vientiane (Lao PDR).

    PubMed

    Vallée, Julie; Souris, Marc; Fournet, Florence; Bochaton, Audrey; Mobillion, Virginie; Peyronnie, Karine; Salem, Gérard

    2007-06-01

    Geographical objectives and probabilistic methods are difficult to reconcile in a unique health survey. Probabilistic methods focus on individuals to provide estimates of a variable's prevalence with a certain precision, while geographical approaches emphasise the selection of specific areas to study interactions between spatial characteristics and health outcomes. A sample selected from a small number of specific areas creates statistical challenges: the observations are not independent at the local level, and this results in poor statistical validity at the global level. Therefore, it is difficult to construct a sample that is appropriate for both geographical and probability methods. We used a two-stage selection procedure with a first non-random stage of selection of clusters. Instead of randomly selecting clusters, we deliberately chose a group of clusters, which as a whole would contain all the variation in health measures in the population. As there was no health information available before the survey, we selected a priori determinants that can influence the spatial homogeneity of the health characteristics. This method yields a distribution of variables in the sample that closely resembles that in the overall population, something that cannot be guaranteed with randomly-selected clusters, especially if the number of selected clusters is small. In this way, we were able to survey specific areas while minimising design effects and maximising statistical precision. We applied this strategy in a health survey carried out in Vientiane, Lao People's Democratic Republic. We selected well-known health determinants with unequal spatial distribution within the city: nationality and literacy. We deliberately selected a combination of clusters whose distribution of nationality and literacy is similar to the distribution in the general population. This paper describes the conceptual reasoning behind the construction of the survey sample and shows that it can be advantageous to choose clusters using reasoned hypotheses, based on both probability and geographical approaches, in contrast to a conventional, random cluster selection strategy.

  16. Targeting hunter distribution based on host resource selection and kill sites to manage disease risk.

    PubMed

    Dugal, Cherie J; van Beest, Floris M; Vander Wal, Eric; Brook, Ryan K

    2013-10-01

    Endemic and emerging diseases are rarely uniform in their spatial distribution or prevalence among cohorts of wildlife. Spatial models that quantify risk-driven differences in resource selection and hunter mortality of animals at fine spatial scales can assist disease management by identifying high-risk areas and individuals. We used resource selection functions (RSFs) and selection ratios (SRs) to quantify sex- and age-specific resource selection patterns of collared (n = 67) and hunter-killed (n = 796) nonmigratory elk (Cervus canadensis manitobensis) during the hunting season between 2002 and 2012, in southwestern Manitoba, Canada. Distance to protected area was the most important covariate influencing resource selection and hunter-kill sites of elk (AICw = 1.00). Collared adult males (which are most likely to be infected with bovine tuberculosis (Mycobacterium bovis) and chronic wasting disease) rarely selected for sites outside of parks during the hunting season in contrast to adult females and juvenile males. The RSFs showed selection by adult females and juvenile males to be negatively associated with landscape-level forest cover, high road density, and water cover, whereas hunter-kill sites of these cohorts were positively associated with landscape-level forest cover and increasing distance to streams and negatively associated with high road density. Local-level forest was positively associated with collared animal locations and hunter-kill sites; however, selection was stronger for collared juvenile males and hunter-killed adult females. In instances where disease infects a metapopulation and eradication is infeasible, a principle goal of management is to limit the spread of disease among infected animals. We map high-risk areas that are regularly used by potentially infectious hosts but currently underrepresented in the distribution of kill sites. We present a novel application of widely available data to target hunter distribution based on host resource selection and kill sites as a promising tool for applying selective hunting to the management of transmissible diseases in a game species.

  17. The scale-dependent impact of wolf predation risk on resource selection by three sympatric ungulates.

    PubMed

    Kittle, Andrew M; Fryxell, John M; Desy, Glenn E; Hamr, Joe

    2008-08-01

    Resource selection is a fundamental ecological process impacting population dynamics and ecosystem structure. Understanding which factors drive selection is vital for effective species- and landscape-level management. We used resource selection probability functions (RSPFs) to study the influence of two forms of wolf (Canis lupus) predation risk, snow conditions and habitat variables on white-tailed deer (Odocoileus virginianus), elk (Cervus elaphus) and moose (Alces alces) resource selection in central Ontario's mixed forest French River-Burwash ecosystem. Direct predation risk was defined as the frequency of a predator's occurrence across the landscape and indirect predation risk as landscape features associated with a higher risk of predation. Models were developed for two winters, each at two spatial scales, using a combination of GIS-derived and ground-measured data. Ungulate presence was determined from snow track transects in 64 16- and 128 1-km(2) resource units, and direct predation risk from GPS radio collar locations of four adjacent wolf packs. Ungulates did not select resources based on the avoidance of areas of direct predation risk at any scale, and instead exhibited selection patterns that tradeoff predation risk minimization with forage and/or mobility requirements. Elk did not avoid indirect predation risk, while both deer and moose exhibited inconsistent responses to this risk. Direct predation risk was more important to models than indirect predation risk but overall, abiotic topographical factors were most influential. These results indicate that wolf predation risk does not limit ungulate habitat use at the scales investigated and that responses to spatial sources of predation risk are complex, incorporating a variety of anti-predator behaviours. Moose resource selection was influenced less by snow conditions than cover type, particularly selection for dense forest, whereas deer showed the opposite pattern. Temporal and spatial scale influenced resource selection by all ungulate species, underlining the importance of incorporating scale into resource selection studies.

  18. Right hemisphere dominance during spatial selective attention and target detection occurs outside the dorsal fronto-parietal network

    PubMed Central

    Shulman, Gordon L.; Pope, Daniel L. W.; Astafiev, Serguei V.; McAvoy, Mark P.; Snyder, Abraham Z.; Corbetta, Maurizio

    2010-01-01

    Spatial selective attention is widely considered to be right hemisphere dominant. Previous functional magnetic resonance imaging (fMRI) studies, however, have reported bilateral blood-oxygenation-level-dependent (BOLD) responses in dorsal fronto-parietal regions during anticipatory shifts of attention to a location (Kastner et al., 1999; Corbetta et al., 2000; Hopfinger et al., 2000). Right-lateralized activity has mainly been reported in ventral fronto-parietal regions for shifts of attention to an unattended target stimulus (Arrington et al., 2000; Corbetta et al., 2000). However, clear conclusions cannot be drawn from these studies because hemispheric asymmetries were not assessed using direct voxel-wise comparisons of activity in left and right hemispheres. Here, we used this technique to measure hemispheric asymmetries during shifts of spatial attention evoked by a peripheral cue stimulus and during target detection at the cued location. Stimulus-driven shifts of spatial attention in both visual fields evoked right-hemisphere dominant activity in temporo-parietal junction (TPJ). Target detection at the attended location produced a more widespread right hemisphere dominance in frontal, parietal, and temporal cortex, including the TPJ region asymmetrically activated during shifts of spatial attention. However, hemispheric asymmetries were not observed during either shifts of attention or target detection in the dorsal fronto-parietal regions (anterior precuneus, medial intraparietal sulcus, frontal eye fields) that showed the most robust activations for shifts of attention. Therefore, right hemisphere dominance during stimulus-driven shifts of spatial attention and target detection reflects asymmetries in cortical regions that are largely distinct from the dorsal fronto-parietal network involved in the control of selective attention. PMID:20219998

  19. Effects of the GluN2B-NMDA receptor antagonist Ro 25-6981 on two types of behavioral flexibility in rats.

    PubMed

    Clark, Emma; Antoniak, Kristen; Feniquito, Alyssandra; Dringenberg, Hans C

    2017-02-15

    Recent evidence has implicated N-methyl-d-aspartate receptors (NMDARs) in several aspects of learning and behavioral flexibility in rodents. Here, we examined the effects of treatment with Ro 25-6981, a selective antagonist of NMDARs containing GluN2B subunits, on two types of behavioral flexibility in rats, spatial reversal learning and set-shifting (spatial vs. motor strategy). To examine spatial reversal learning, rats were trained to swim to a hidden platform in a water maze over four days. On the following day, the platform was moved to a new location in the maze. Administration of Ro 25-6981 (10mg/kg) selectively impaired the early phase of reversal learning, but all rats learned to navigate to the new platform location over 12 trials. To examine set-shifting, independent groups of rats were trained to either swim to a fixed location (spatial strategy) or use a motor response (e.g., "turn left"; motor strategy) to find a hidden escape platform in a cross-shaped water maze apparatus; after task acquisition, rats were trained on the second, novel strategy (set-shift) following treatment with either Ro 25-6981 (10mg/kg) or saline. Administration of Ro 25-6981 had no effect on the ability of rats to perform the set-shift and use the new strategy to locate the escape platform. These results suggest that, in rats, spatial reversal learning, but not set-shifting, is sensitive to Ro-25-6981 treatment. Thus, NMDARs-GluN2B signaling may play a selective role in some forms of behavioral plasticity, particularly for situations involving the updating of information in the spatial domain. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Navigating the currents of seascape genomics: how spatial analyses can augment population genomic studies

    PubMed Central

    Crandall, Eric D.; Liggins, Libby; Bongaerts, Pim; Treml, Eric A.

    2016-01-01

    Population genomic approaches are making rapid inroads in the study of non-model organisms, including marine taxa. To date, these marine studies have predominantly focused on rudimentary metrics describing the spatial and environmental context of their study region (e.g., geographical distance, average sea surface temperature, average salinity). We contend that a more nuanced and considered approach to quantifying seascape dynamics and patterns can strengthen population genomic investigations and help identify spatial, temporal, and environmental factors associated with differing selective regimes or demographic histories. Nevertheless, approaches for quantifying marine landscapes are complicated. Characteristic features of the marine environment, including pelagic living in flowing water (experienced by most marine taxa at some point in their life cycle), require a well-designed spatial-temporal sampling strategy and analysis. Many genetic summary statistics used to describe populations may be inappropriate for marine species with large population sizes, large species ranges, stochastic recruitment, and asymmetrical gene flow. Finally, statistical approaches for testing associations between seascapes and population genomic patterns are still maturing with no single approach able to capture all relevant considerations. None of these issues are completely unique to marine systems and therefore similar issues and solutions will be shared for many organisms regardless of habitat. Here, we outline goals and spatial approaches for landscape genomics with an emphasis on marine systems and review the growing empirical literature on seascape genomics. We review established tools and approaches and highlight promising new strategies to overcome select issues including a strategy to spatially optimize sampling. Despite the many challenges, we argue that marine systems may be especially well suited for identifying candidate genomic regions under environmentally mediated selection and that seascape genomic approaches are especially useful for identifying robust locus-by-environment associations. PMID:29491947

  1. Navigating the currents of seascape genomics: how spatial analyses can augment population genomic studies.

    PubMed

    Riginos, Cynthia; Crandall, Eric D; Liggins, Libby; Bongaerts, Pim; Treml, Eric A

    2016-12-01

    Population genomic approaches are making rapid inroads in the study of non-model organisms, including marine taxa. To date, these marine studies have predominantly focused on rudimentary metrics describing the spatial and environmental context of their study region (e.g., geographical distance, average sea surface temperature, average salinity). We contend that a more nuanced and considered approach to quantifying seascape dynamics and patterns can strengthen population genomic investigations and help identify spatial, temporal, and environmental factors associated with differing selective regimes or demographic histories. Nevertheless, approaches for quantifying marine landscapes are complicated. Characteristic features of the marine environment, including pelagic living in flowing water (experienced by most marine taxa at some point in their life cycle), require a well-designed spatial-temporal sampling strategy and analysis. Many genetic summary statistics used to describe populations may be inappropriate for marine species with large population sizes, large species ranges, stochastic recruitment, and asymmetrical gene flow. Finally, statistical approaches for testing associations between seascapes and population genomic patterns are still maturing with no single approach able to capture all relevant considerations. None of these issues are completely unique to marine systems and therefore similar issues and solutions will be shared for many organisms regardless of habitat. Here, we outline goals and spatial approaches for landscape genomics with an emphasis on marine systems and review the growing empirical literature on seascape genomics. We review established tools and approaches and highlight promising new strategies to overcome select issues including a strategy to spatially optimize sampling. Despite the many challenges, we argue that marine systems may be especially well suited for identifying candidate genomic regions under environmentally mediated selection and that seascape genomic approaches are especially useful for identifying robust locus-by-environment associations.

  2. Attention improves encoding of task-relevant features in the human visual cortex

    PubMed Central

    Jehee, Janneke F.M.; Brady, Devin K.; Tong, Frank

    2011-01-01

    When spatial attention is directed towards a particular stimulus, increased activity is commonly observed in corresponding locations of the visual cortex. Does this attentional increase in activity indicate improved processing of all features contained within the attended stimulus, or might spatial attention selectively enhance the features relevant to the observer’s task? We used fMRI decoding methods to measure the strength of orientation-selective activity patterns in the human visual cortex while subjects performed either an orientation or contrast discrimination task, involving one of two laterally presented gratings. Greater overall BOLD activation with spatial attention was observed in areas V1-V4 for both tasks. However, multivariate pattern analysis revealed that orientation-selective responses were enhanced by attention only when orientation was the task-relevant feature, and not when the grating’s contrast had to be attended. In a second experiment, observers discriminated the orientation or color of a specific lateral grating. Here, orientation-selective responses were enhanced in both tasks but color-selective responses were enhanced only when color was task-relevant. In both experiments, task-specific enhancement of feature-selective activity was not confined to the attended stimulus location, but instead spread to other locations in the visual field, suggesting the concurrent involvement of a global feature-based attentional mechanism. These results suggest that attention can be remarkably selective in its ability to enhance particular task-relevant features, and further reveal that increases in overall BOLD amplitude are not necessarily accompanied by improved processing of stimulus information. PMID:21632942

  3. Use of strategic environmental assessment in the site selection process for a radioactive waste disposal facility in Slovenia.

    PubMed

    Dermol, Urška; Kontić, Branko

    2011-01-01

    The benefits of strategic environmental considerations in the process of siting a repository for low- and intermediate-level radioactive waste (LILW) are presented. The benefits have been explored by analyzing differences between the two site selection processes. One is a so-called official site selection process, which is implemented by the Agency for radwaste management (ARAO); the other is an optimization process suggested by experts working in the area of environmental impact assessment (EIA) and land-use (spatial) planning. The criteria on which the comparison of the results of the two site selection processes has been based are spatial organization, environmental impact, safety in terms of potential exposure of the population to radioactivity released from the repository, and feasibility of the repository from the technical, financial/economic and social point of view (the latter relates to consent by the local community for siting the repository). The site selection processes have been compared with the support of the decision expert system named DEX. The results of the comparison indicate that the sites selected by ARAO meet fewer suitability criteria than those identified by applying strategic environmental considerations in the framework of the optimization process. This result stands when taking into account spatial, environmental, safety and technical feasibility points of view. Acceptability of a site by a local community could not have been tested, since the formal site selection process has not yet been concluded; this remains as an uncertain and open point of the comparison. Copyright © 2010 Elsevier Ltd. All rights reserved.

  4. Attention improves encoding of task-relevant features in the human visual cortex.

    PubMed

    Jehee, Janneke F M; Brady, Devin K; Tong, Frank

    2011-06-01

    When spatial attention is directed toward a particular stimulus, increased activity is commonly observed in corresponding locations of the visual cortex. Does this attentional increase in activity indicate improved processing of all features contained within the attended stimulus, or might spatial attention selectively enhance the features relevant to the observer's task? We used fMRI decoding methods to measure the strength of orientation-selective activity patterns in the human visual cortex while subjects performed either an orientation or contrast discrimination task, involving one of two laterally presented gratings. Greater overall BOLD activation with spatial attention was observed in visual cortical areas V1-V4 for both tasks. However, multivariate pattern analysis revealed that orientation-selective responses were enhanced by attention only when orientation was the task-relevant feature and not when the contrast of the grating had to be attended. In a second experiment, observers discriminated the orientation or color of a specific lateral grating. Here, orientation-selective responses were enhanced in both tasks, but color-selective responses were enhanced only when color was task relevant. In both experiments, task-specific enhancement of feature-selective activity was not confined to the attended stimulus location but instead spread to other locations in the visual field, suggesting the concurrent involvement of a global feature-based attentional mechanism. These results suggest that attention can be remarkably selective in its ability to enhance particular task-relevant features and further reveal that increases in overall BOLD amplitude are not necessarily accompanied by improved processing of stimulus information.

  5. Hierarchical patch-based co-registration of differently stained histopathology slides

    NASA Astrophysics Data System (ADS)

    Yigitsoy, Mehmet; Schmidt, Günter

    2017-03-01

    Over the past decades, digital pathology has emerged as an alternative way of looking at the tissue at subcellular level. It enables multiplexed analysis of different cell types at micron level. Information about cell types can be extracted by staining sections of a tissue block using different markers. However, robust fusion of structural and functional information from different stains is necessary for reproducible multiplexed analysis. Such a fusion can be obtained via image co-registration by establishing spatial correspondences between tissue sections. Spatial correspondences can then be used to transfer various statistics about cell types between sections. However, the multi-modal nature of images and sparse distribution of interesting cell types pose several challenges for the registration of differently stained tissue sections. In this work, we propose a co-registration framework that efficiently addresses such challenges. We present a hierarchical patch-based registration of intensity normalized tissue sections. Preliminary experiments demonstrate the potential of the proposed technique for the fusion of multi-modal information from differently stained digital histopathology sections.

  6. A face-selective ventral occipito-temporal map of the human brain with intracerebral potentials

    PubMed Central

    Jonas, Jacques; Jacques, Corentin; Liu-Shuang, Joan; Brissart, Hélène; Colnat-Coulbois, Sophie; Maillard, Louis; Rossion, Bruno

    2016-01-01

    Human neuroimaging studies have identified a network of distinct face-selective regions in the ventral occipito-temporal cortex (VOTC), with a right hemispheric dominance. To date, there is no evidence for this hemispheric and regional specialization with direct measures of brain activity. To address this gap in knowledge, we recorded local neurophysiological activity from 1,678 contact electrodes implanted in the VOTC of a large group of epileptic patients (n = 28). They were presented with natural images of objects at a rapid fixed rate (six images per second: 6 Hz), with faces interleaved as every fifth stimulus (i.e., 1.2 Hz). High signal-to-noise ratio face-selective responses were objectively (i.e., exactly at the face stimulation frequency) identified and quantified throughout the whole VOTC. Face-selective responses were widely distributed across the whole VOTC, but also spatially clustered in specific regions. Among these regions, the lateral section of the right middle fusiform gyrus showed the largest face-selective response by far, offering, to our knowledge, the first supporting evidence of two decades of neuroimaging observations with direct neural measures. In addition, three distinct regions with a high proportion of face-selective responses were disclosed in the right ventral anterior temporal lobe, a region that is undersampled in neuroimaging because of magnetic susceptibility artifacts. A high proportion of contacts responding only to faces (i.e., “face-exclusive” responses) were found in these regions, suggesting that they contain populations of neurons involved in dedicated face-processing functions. Overall, these observations provide a comprehensive mapping of visual category selectivity in the whole human VOTC with direct neural measures. PMID:27354526

  7. Spatially Distributed Dendritic Resonance Selectively Filters Synaptic Input

    PubMed Central

    Segev, Idan; Shamma, Shihab

    2014-01-01

    An important task performed by a neuron is the selection of relevant inputs from among thousands of synapses impinging on the dendritic tree. Synaptic plasticity enables this by strenghtening a subset of synapses that are, presumably, functionally relevant to the neuron. A different selection mechanism exploits the resonance of the dendritic membranes to preferentially filter synaptic inputs based on their temporal rates. A widely held view is that a neuron has one resonant frequency and thus can pass through one rate. Here we demonstrate through mathematical analyses and numerical simulations that dendritic resonance is inevitably a spatially distributed property; and therefore the resonance frequency varies along the dendrites, and thus endows neurons with a powerful spatiotemporal selection mechanism that is sensitive both to the dendritic location and the temporal structure of the incoming synaptic inputs. PMID:25144440

  8. Optional games on cycles and complete graphs.

    PubMed

    Jeong, Hyeong-Chai; Oh, Seung-Yoon; Allen, Benjamin; Nowak, Martin A

    2014-09-07

    We study stochastic evolution of optional games on simple graphs. There are two strategies, A and B, whose interaction is described by a general payoff matrix. In addition, there are one or several possibilities to opt out from the game by adopting loner strategies. Optional games lead to relaxed social dilemmas. Here we explore the interaction between spatial structure and optional games. We find that increasing the number of loner strategies (or equivalently increasing mutational bias toward loner strategies) facilitates evolution of cooperation both in well-mixed and in structured populations. We derive various limits for weak selection and large population size. For some cases we derive analytic results for strong selection. We also analyze strategy selection numerically for finite selection intensity and discuss combined effects of optionality and spatial structure. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stegen, James C.; Lin, Xueju; Fredrickson, Jim K.

    Across a set of ecological communities connected to each other through organismal dispersal (a ‘meta-community’), turnover in composition is governed by (ecological) Drift, Selection, and Dispersal Limitation. Quantitative estimates of these processes remain elusive, but would represent a common currency needed to unify community ecology. Using a novel analytical framework we quantitatively estimate the relative influences of Drift, Selection, and Dispersal Limitation on subsurface, sediment-associated microbial meta-communities. The communities we study are distributed across two geologic formations encompassing ~12,500m3 of uranium-contaminated sediments within the Hanford Site in eastern Washington State. We find that Drift consistently governs ~25% of spatial turnovermore » in community composition; Selection dominates (governing ~60% of turnover) across spatially-structured habitats associated with fine-grained, low permeability sediments; and Dispersal Limitation is most influential (governing ~40% of turnover) across spatially-unstructured habitats associated with coarse-grained, highly-permeable sediments. Quantitative influences of Selection and Dispersal Limitation may therefore be predictable from knowledge of environmental structure. To develop a system-level conceptual model we extend our analytical framework to compare process estimates across formations, characterize measured and unmeasured environmental variables that impose Selection, and identify abiotic features that limit dispersal. Insights gained here suggest that community ecology can benefit from a shift in perspective; the quantitative approach developed here goes beyond the ‘niche vs. neutral’ dichotomy by moving towards a style of natural history in which estimates of Selection, Dispersal Limitation and Drift can be described, mapped and compared across ecological systems.« less

  10. Observation and studies of double J / ψ production at the Tevatron

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abazov, V. M.; Abbott, B.; Acharya, B. S.

    2014-12-01

    We present the observation of doubly-producedmore » $$J/\\psi$$ mesons with the D0 detector at Fermilab in $$p\\bar{p}$$ collisions at $$\\sqrt{s}=1.96$$ TeV. The production cross section for both singly and doubly-produced $$J/\\psi$$ mesons is measured using a sample with an integrated luminosity of 8.1fb$$^{-1}$$. For the first time, the double $$J/\\psi$$ production cross section is separated into contributions due to single and double parton scatterings. Using these measurements, we determine the effective cross section $$\\sigma_{eff}$$, a parameter characterizing an effective spatial area of the parton-parton interactions and related to the parton spatial density inside the nucleon.« less

  11. The selective serotonin reuptake inhibitor, escitalopram, enhances inhibition of prepotent responding and spatial reversal learning

    PubMed Central

    Brown, Holden D.; Amodeo, Dionisio A.; Sweeney, John A.; Ragozzino, Michael E.

    2011-01-01

    Previous findings indicate treatment with a selective serotonin reuptake inhibitor (SSRI) facilitates behavioral flexibility when conditions require inhibition of a learned response pattern. The present experiment investigated whether acute treatment with the SSRI, escitalopram, affects behavioral flexibility when conditions require inhibition of a naturally-biased response pattern (elevated conflict test) and/or reversal of a learned response pattern (spatial reversal learning). An additional experiment was carried out to determine whether escitalopram, at doses that affected behavioral flexibility, also reduced anxiety as tested in the elevated plus-maze. In each experiment, Long-Evans rats received an intraperitoneal injection of either saline or escitalopram (0.03, 0.3 or 1.0 mg/kg) 30 minutes prior to behavioral testing. Escitalopram, at all doses tested, enhanced acquisition in the elevated conflict test, but did not affect performance in the elevated plus-maze. Escitalopram (0.3 and 1.0 mg/kg) did not alter acquisition of the spatial discrimination, but facilitated reversal learning. In the elevated conflict and spatial reversal learning test, escitalopram enhanced the ability to maintain the relevant strategy after being initially selected. The present findings suggest that enhancing serotonin transmission with a SSRI facilitates inhibitory processes when conditions require a shift away from either a naturally-biased response pattern or a learned choice pattern. PMID:22219222

  12. Hedonic valuation of the spatial competition for urban circumstance utilities: case Wuhan, China

    NASA Astrophysics Data System (ADS)

    Zheng, Bin; Liu, Yaolin; Huang, Lina

    2008-10-01

    It has generally accepted Alonso's [1] theory about the allocation of different land uses of commerce, resident and industry in urban area. A bunch of researches have provided their aspects of the theme of the relationships between urban circumstances and urban land uses in either the influence of one or several designate circumstance factors on different land uses, or the comprehensive analysis of the influence of all kinds of circumstance on one selected land usage (e.g. residential use). There is still not a wholly analysis about the influence of all kinds of spatial characteristics, available for the location selection of different land uses. That's why this research selects to engage in a study on the difference among "consumer preferences" to the location amenities in the city. Here we regard the behavior as "spatial competition of the locations". Hedonic regression model (HRM) analysis is employed as the basic framework of the research. Tabular comparison of HRM parameters performed with principal components analysis (PCA) and Geographic Information Science (GIS) provides all necessary numerical investigation and spatial analysis until to the finally results. The research can be helpful for putting forward to a further integrated investigation on the relationship between urban circumstance and real land use values.

  13. Geoscience after ITPart G. Familiarization with spatial analysis

    NASA Astrophysics Data System (ADS)

    Pundt, Hardy; Brinkkötter-Runde, Klaus

    2000-04-01

    Field based and GPS supported GIS are increasingly applied in various spatial disciplines. Such systems represent more sophisticated, time and cost effective tools than traditional field forms for data acquisition. Meanwhile, various systems are on the market. These mostly enable the user to define geo-objects by means of GPS information, supported by functionalities to collect and analyze geometric information. The digital acquisition of application specific attributes is often underrepresented within such systems. This is surprising because pen computer based GIS can be used to collect attributes in a profitable manner, thus adequately supporting the requirements of the user. Visualization and graphic displays of spatial data are helpful means to improve such a data collection process. In section one and two basic aspects of visualization and current uses of visualization techniques for field based GIS are described. Section three mentions new developments within the framework of wearable computing and augmented reality. Section four describes current activities aimed at the realization of real time online field based GIS. This includes efforts to realize an online GIS data link to improve the efficiency and the quality of fieldwork. A brief discussion in section five leads to conclusions and some key issues for future research.

  14. Quantifying spatial habitat loss from hydrocarbon development through assessing habitat selection patterns of mule deer.

    PubMed

    Northrup, Joseph M; Anderson, Charles R; Wittemyer, George

    2015-11-01

    Extraction of oil and natural gas (hydrocarbons) from shale is increasing rapidly in North America, with documented impacts to native species and ecosystems. With shale oil and gas resources on nearly every continent, this development is set to become a major driver of global land-use change. It is increasingly critical to quantify spatial habitat loss driven by this development to implement effective mitigation strategies and develop habitat offsets. Habitat selection is a fundamental ecological process, influencing both individual fitness and population-level distribution on the landscape. Examinations of habitat selection provide a natural means for understanding spatial impacts. We examined the impact of natural gas development on habitat selection patterns of mule deer on their winter range in Colorado. We fit resource selection functions in a Bayesian hierarchical framework, with habitat availability defined using a movement-based modeling approach. Energy development drove considerable alterations to deer habitat selection patterns, with the most substantial impacts manifested as avoidance of well pads with active drilling to a distance of at least 800 m. Deer displayed more nuanced responses to other infrastructure, avoiding pads with active production and roads to a greater degree during the day than night. In aggregate, these responses equate to alteration of behavior by human development in over 50% of the critical winter range in our study area during the day and over 25% at night. Compared to other regions, the topographic and vegetative diversity in the study area appear to provide refugia that allow deer to behaviorally mediate some of the impacts of development. This study, and the methods we employed, provides a template for quantifying spatial take by industrial activities in natural areas and the results offer guidance for policy makers, mangers, and industry when attempting to mitigate habitat loss due to energy development. © 2015 The Authors. Global Change Biology Published by John Wiley & Sons Ltd.

  15. A novel approach to assessing environmental disturbance based on habitat selection by zebra fish as a model organism.

    PubMed

    Araújo, Cristiano V M; Griffith, Daniel M; Vera-Vera, Victoria; Jentzsch, Paul Vargas; Cervera, Laura; Nieto-Ariza, Beatriz; Salvatierra, David; Erazo, Santiago; Jaramillo, Rusbel; Ramos, Luis A; Moreira-Santos, Matilde; Ribeiro, Rui

    2018-04-01

    Aquatic ecotoxicity assays used to assess ecological risk assume that organisms living in a contaminated habitat are forcedly exposed to the contamination. This assumption neglects the ability of organisms to detect and avoid contamination by moving towards less disturbed habitats, as long as connectivity exists. In fluvial systems, many environmental parameters vary spatially and thus condition organisms' habitat selection. We assessed the preference of zebra fish (Danio rerio) when exposed to water samples from two western Ecuadorian rivers with apparently distinct disturbance levels: Pescadillo River (highly disturbed) and Oro River (moderately disturbed). Using a non-forced exposure system in which water samples from each river were arranged according to their spatial sequence in the field and connected to allow individuals to move freely among samples, we assayed habitat selection by D. rerio to assess environmental disturbance in the two rivers. Fish exposed to Pescadillo River samples preferred downstream samples near the confluence zone with the Oro River. Fish exposed to Oro River samples preferred upstream waters. When exposed to samples from both rivers simultaneously, fish exhibited the same pattern of habitat selection by preferring the Oro River samples. Given that the rivers are connected, preference for the Oro River enabled us to predict a depression in fish populations in the Pescadillo River. Although these findings indicate higher disturbance levels in the Pescadillo River, none of the physical-chemical variables measured was significantly correlated with the preference pattern towards the Oro River. Non-linear spatial patterns of habitat preference suggest that other environmental parameters like urban or agricultural contaminants play an important role in the model organism's habitat selection in these rivers. The non-forced exposure system represents a habitat selection-based approach that can serve as a valuable tool to unravel the factors that dictate organisms' spatial distribution in connected ecosystems. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. What top-down task sets do for us: an ERP study on the benefits of advance preparation in visual search.

    PubMed

    Eimer, Martin; Kiss, Monika; Nicholas, Susan

    2011-12-01

    When target-defining features are specified in advance, attentional target selection in visual search is controlled by preparatory top-down task sets. We used ERP measures to study voluntary target selection in the absence of such feature-specific task sets, and to compare it to selection that is guided by advance knowledge about target features. Visual search arrays contained two different color singleton digits, and participants had to select one of these as target and report its parity. Target color was either known in advance (fixed color task) or had to be selected anew on each trial (free color-choice task). ERP correlates of spatially selective attentional target selection (N2pc) and working memory processing (SPCN) demonstrated rapid target selection and efficient exclusion of color singleton distractors from focal attention and working memory in the fixed color task. In the free color-choice task, spatially selective processing also emerged rapidly, but selection efficiency was reduced, with nontarget singleton digits capturing attention and gaining access to working memory. Results demonstrate the benefits of top-down task sets: Feature-specific advance preparation accelerates target selection, rapidly resolves attentional competition, and prevents irrelevant events from attracting attention and entering working memory.

  17. Improving spectral resolution in spatial encoding dimension of single-scan nuclear magnetic resonance 2D spin echo correlated spectroscopy

    NASA Astrophysics Data System (ADS)

    Lin, Liangjie; Wei, Zhiliang; Yang, Jian; Lin, Yanqin; Chen, Zhong

    2014-11-01

    The spatial encoding technique can be used to accelerate the acquisition of multi-dimensional nuclear magnetic resonance spectra. However, with this technique, we have to make trade-offs between the spectral width and the resolution in the spatial encoding dimension (F1 dimension), resulting in the difficulty of covering large spectral widths while preserving acceptable resolutions for spatial encoding spectra. In this study, a selective shifting method is proposed to overcome the aforementioned drawback. This method is capable of narrowing spectral widths and improving spectral resolutions in spatial encoding dimensions by selectively shifting certain peaks in spectra of the ultrafast version of spin echo correlated spectroscopy (UFSECSY). This method can also serve as a powerful tool to obtain high-resolution correlated spectra in inhomogeneous magnetic fields for its resistance to any inhomogeneity in the F1 dimension inherited from UFSECSY. Theoretical derivations and experiments have been carried out to demonstrate performances of the proposed method. Results show that the spectral width in spatial encoding dimension can be reduced by shortening distances between cross peaks and axial peaks with the proposed method and the expected resolution improvement can be achieved. Finally, the shifting-absent spectrum can be recovered readily by post-processing.

  18. Calendar of Selected Aeronautical & Space Meetings, January 1990 (Calendrier des Manifestations Aeronautiques et Spatiales (Selection) Janvier 1990

    DTIC Science & Technology

    1990-01-01

    aide aux membres de la Communaut6 a~ronautique et spatiale: * En les informant de nombreuses manifestations internationales pr~vues dans les domaines ...chronologiquement. Edit6 en d~cembre 1989 Copyright 0 AGARD 1989 Tous droits r~serv~s ISBN 92-835-0536-0 bik Composc et imprimi par Specialised Printing Services...of the Calendar by using the Meeting Forms printed on the last pages of this issue). iv PREFACE L’objet de cette publication de I’AGARD est de venir en

  19. Experimental studies of adaptation in Clarkia xantiana. III. Phenotypic selection across a subspecies border.

    PubMed

    Anderson, Jill T; Eckhart, Vincent M; Geber, Monica A

    2015-09-01

    Sister taxa with distinct phenotypes often occupy contrasting environments in parapatric ranges, yet we generally do not know whether trait divergence reflects spatially varying selection. We conducted a reciprocal transplant experiment to test whether selection favors "native phenotypes" in two subspecies of Clarkia xantiana (Onagraceae), an annual plant in California. For four quantitative traits that differ between subspecies, we estimated phenotypic selection in subspecies' exclusive ranges and their contact zone in two consecutive years. We predicted that in the arid, pollinator-scarce eastern region, selection favors phenotypes of the native subspecies parviflora: small leaves, slow leaf growth, early flowering, and diminutive flowers. In the wetter, pollinator-rich, western range of subspecies xantiana, we expected selection for opposite phenotypes. We investigated pollinator contributions to selection by comparing naturally pollinated and pollen-supplemented individuals. For reproductive traits and for subspecies xantiana, selection generally matched expectations. The contact zone sometimes showed distinctive selection, and in ssp. parviflora selection sometimes favored nonnative phenotypes. Pollinators influenced selection on flowering time but not on flower size. Little temporal variation in selection occurred, possibly because of plastic trait responses across years. Though there were exceptions and some causes of selection remain obscure, phenotypic differentiation between subspecies appears to reflect spatially variable selection. © 2015 The Author(s). Evolution © 2015 The Society for the Study of Evolution.

  20. SPATIAL PATTERNS AND ECOLOGICAL DETERMINANTS OF BENTHIC ALGAL ASSEMBLAGES IN MID-ATLANTIC STREAMS, USA

    EPA Science Inventory

    We attempted to identify spatial patterns and determinants for benthic algal assemblages in Mid-Atlantic streams. Periphyton, water chemistry, stream physical habitat, riparian conditions, and land cover/use in watersheds were characterized at 89 randomly selected stream sites i...

  1. Counseling Interactions as a Function of Spatial-Environmental Conditions.

    ERIC Educational Resources Information Center

    Lecomte, Conrad; And Others

    1981-01-01

    Investigated the effects of selected spatial-environmental conditions on counselor and counselee interview behaviors. Rated excerpts from initial sessions. Results indicated significant effects of distance on counselor concreteness, lighting on counselor communication of cognitive sets and distance on counselee affective self-disclosure in later…

  2. Cross-Sensory Transfer of Reference Frames in Spatial Memory

    ERIC Educational Resources Information Center

    Kelly, Jonathan W.; Avraamides, Marios N.

    2011-01-01

    Two experiments investigated whether visual cues influence spatial reference frame selection for locations learned through touch. Participants experienced visual cues emphasizing specific environmental axes and later learned objects through touch. Visual cues were manipulated and haptic learning conditions were held constant. Imagined perspective…

  3. Selective spatial attention modulates bottom-up informational masking of speech

    PubMed Central

    Carlile, Simon; Corkhill, Caitlin

    2015-01-01

    To hear out a conversation against other talkers listeners overcome energetic and informational masking. Largely attributed to top-down processes, information masking has also been demonstrated using unintelligible speech and amplitude-modulated maskers suggesting bottom-up processes. We examined the role of speech-like amplitude modulations in information masking using a spatial masking release paradigm. Separating a target talker from two masker talkers produced a 20 dB improvement in speech reception threshold; 40% of which was attributed to a release from informational masking. When across frequency temporal modulations in the masker talkers are decorrelated the speech is unintelligible, although the within frequency modulation characteristics remains identical. Used as a masker as above, the information masking accounted for 37% of the spatial unmasking seen with this masker. This unintelligible and highly differentiable masker is unlikely to involve top-down processes. These data provides strong evidence of bottom-up masking involving speech-like, within-frequency modulations and that this, presumably low level process, can be modulated by selective spatial attention. PMID:25727100

  4. Selective spatial attention modulates bottom-up informational masking of speech.

    PubMed

    Carlile, Simon; Corkhill, Caitlin

    2015-03-02

    To hear out a conversation against other talkers listeners overcome energetic and informational masking. Largely attributed to top-down processes, information masking has also been demonstrated using unintelligible speech and amplitude-modulated maskers suggesting bottom-up processes. We examined the role of speech-like amplitude modulations in information masking using a spatial masking release paradigm. Separating a target talker from two masker talkers produced a 20 dB improvement in speech reception threshold; 40% of which was attributed to a release from informational masking. When across frequency temporal modulations in the masker talkers are decorrelated the speech is unintelligible, although the within frequency modulation characteristics remains identical. Used as a masker as above, the information masking accounted for 37% of the spatial unmasking seen with this masker. This unintelligible and highly differentiable masker is unlikely to involve top-down processes. These data provides strong evidence of bottom-up masking involving speech-like, within-frequency modulations and that this, presumably low level process, can be modulated by selective spatial attention.

  5. Maritime Spatial Planning supported by systematic site selection: Applying Marxan for offshore wind power in the western Baltic Sea

    PubMed Central

    Dahl, Karsten; Mohn, Christian

    2018-01-01

    The development of offshore wind energy and other competing interests in sea space are a major incentive for designating marine and coastal areas for specific human activities. Maritime Spatial Planning (MSP) considers human activities at sea in a more integrated way by analysing and designating spatial and temporal distributions of human activities based on ecological, economic and social targets. However, specific tools supporting spatial decisions at sea incorporating all relevant sectors are rarely adopted. The decision support tool Marxan is traditionally used for systematic selection and designation of nature protection and conservation areas. In this study, Marxan was applied as a support tool to identify suitable sites for offshore wind power in the pilot area Pomeranian Bight / Arkona Basin in the western Baltic Sea. The software was successfully tested and scenarios were developed that support the sites indicated in existing national plans, but also show options for alternative developments of offshore wind power in the Pomeranian Bight / Arkona Basin area. PMID:29543878

  6. Neuropsychology of selective attention and magnetic cortical stimulation.

    PubMed

    Sabatino, M; Di Nuovo, S; Sardo, P; Abbate, C S; La Grutta, V

    1996-01-01

    Informed volunteers were asked to perform different neuropsychological tests involving selective attention under control conditions and during transcranial magnetic cortical stimulation. The tests chosen involved the recognition of a specific letter among different letters (verbal test) and the search for three different spatial orientations of an appendage to a square (visuo-spatial test). For each test the total time taken and the error rate were calculated. Results showed that cortical stimulation did not cause a worsening in performance. Moreover, magnetic stimulation of the temporal lobe neither modified completion time in both verbal and visuo-spatial tests nor changed error rate. In contrast, magnetic stimulation of the pre-frontal area induced a significant reduction in the performance time of both the verbal and visuo-spatial tests always without an increase in the number of errors. The experimental findings underline the importance of the pre-frontal area in performing tasks requiring a high level of controlled attention and suggest the need to adopt an interdisciplinary approach towards the study of neurone/mind interface mechanisms.

  7. Preemptive spatial competition under a reproduction-mortality constraint.

    PubMed

    Allstadt, Andrew; Caraco, Thomas; Korniss, G

    2009-06-21

    Spatially structured ecological interactions can shape selection pressures experienced by a population's different phenotypes. We study spatial competition between phenotypes subject to antagonistic pleiotropy between reproductive effort and mortality rate. The constraint we invoke reflects a previous life-history analysis; the implied dependence indicates that although propagation and mortality rates both vary, their ratio is fixed. We develop a stochastic invasion approximation predicting that phenotypes with higher propagation rates will invade an empty environment (no biotic resistance) faster, despite their higher mortality rate. However, once population density approaches demographic equilibrium, phenotypes with lower mortality are favored, despite their lower propagation rate. We conducted a set of pairwise invasion analyses by simulating an individual-based model of preemptive competition. In each case, the phenotype with the lowest mortality rate and (via antagonistic pleiotropy) the lowest propagation rate qualified as evolutionarily stable among strategies simulated. This result, for a fixed propagation to mortality ratio, suggests that a selective response to spatial competition can extend the time scale of the population's dynamics, which in turn decelerates phenotypic evolution.

  8. Spatial filter with volume gratings for high-peak-power multistage laser amplifiers

    NASA Astrophysics Data System (ADS)

    Tan, Yi-zhou; Yang, Yi-sheng; Zheng, Guang-wei; Shen, Ben-jian; Pan, Heng-yue; Liu, Li

    2010-08-01

    The regular spatial filters comprised of lens and pinhole are essential component in high power laser systems, such as lasers for inertial confinement fusion, nonlinear optical technology and directed-energy weapon. On the other hand the pinhole is treated as a bottleneck of high power laser due to harmful plasma created by the focusing beam. In this paper we present a spatial filter based on angular selectivity of Bragg diffraction grating to avoid the harmful focusing effect in the traditional pinhole filter. A spatial filter consisted of volume phase gratings in two-pass amplifier cavity were reported. Two-dimensional filter was proposed by using single Pi-phase-shifted Bragg grating, numerical simulation results shown that its angular spectrum bandwidth can be less than 160urad. The angular selectivity of photo-thermorefractive glass and RUGATE film filters, construction stability, thermal stability and the effects of misalignments of gratings on the diffraction efficiencies under high-pulse-energy laser operating condition are discussed.

  9. Abnormal Spatial Asymmetry of Selective Attention in ADHD

    ERIC Educational Resources Information Center

    Chan, Edgar; Mattingley, Jason B.; Huang-Pollock, Cynthia; English, Therese; Hester, Robert; Vance, Alasdair; Bellgrove, Mark A.

    2009-01-01

    Background: Evidence for a selective attention abnormality in children with attention deficit hyperactivity disorder (ADHD) has been hard to identify using conventional methods from cognitive science. This study tested whether the presence of selective attention abnormalities in ADHD may vary as a function of perceptual load and target…

  10. Terrain type recognition using ERTS-1 MSS images

    NASA Technical Reports Server (NTRS)

    Gramenopoulos, N.

    1973-01-01

    For the automatic recognition of earth resources from ERTS-1 digital tapes, both multispectral and spatial pattern recognition techniques are important. Recognition of terrain types is based on spatial signatures that become evident by processing small portions of an image through selected algorithms. An investigation of spatial signatures that are applicable to ERTS-1 MSS images is described. Artifacts in the spatial signatures seem to be related to the multispectral scanner. A method for suppressing such artifacts is presented. Finally, results of terrain type recognition for one ERTS-1 image are presented.

  11. Signal Enhancement and Suppression During Visual-Spatial Selective Attention

    PubMed Central

    Couperus, J. W.; Mangun, G.R.

    2010-01-01

    Selective attention involves the relative enhancement of relevant versus irrelevant stimuli. However, whether this relative enhancement involves primarily enhancement of attended stimuli, or suppression of irrelevant stimuli, remains controversial. Moreover, if both enhancement and suppression are involved, whether they result from a single mechanism or separate mechanisms during attentional control or selection is not known. In two experiments using a spatial cuing paradigm with task-relevant targets and irrelevant distractors, target and distracter processing was examined as a function of distractor expectancy. Additionally, in the second study the interaction of perceptual load and distractor expectancy was explored. In both experiments, distractors were either validly cued (70%) or invalidly cued (30%) in order to examine the effects of distractor expectancy on attentional control as well as target and distractor processing. The effects of distractor expectancy were assessed using event-related potentials recorded during the cue-to-target period (preparatory attention) and in response to the task-relevant target stimuli (selective stimulus processing). Analyses of distractor-present displays (anticipated versus unanticipated), showed modulations in brain activity during both the preparatory period and during target processing. The pattern of brain responses suggest both facilitation of attended targets and suppression of unattended distractors. These findings provide evidence for a two-process model of visual spatial selective attention, where one mechanism (facilitation) influences relevant stimuli and another (suppression) acts to filter distracting stimuli. PMID:20807513

  12. Estimating and mapping ecological processes influencing microbial community assembly

    PubMed Central

    Stegen, James C.; Lin, Xueju; Fredrickson, Jim K.; Konopka, Allan E.

    2015-01-01

    Ecological community assembly is governed by a combination of (i) selection resulting from among-taxa differences in performance; (ii) dispersal resulting from organismal movement; and (iii) ecological drift resulting from stochastic changes in population sizes. The relative importance and nature of these processes can vary across environments. Selection can be homogeneous or variable, and while dispersal is a rate, we conceptualize extreme dispersal rates as two categories; dispersal limitation results from limited exchange of organisms among communities, and homogenizing dispersal results from high levels of organism exchange. To estimate the influence and spatial variation of each process we extend a recently developed statistical framework, use a simulation model to evaluate the accuracy of the extended framework, and use the framework to examine subsurface microbial communities over two geologic formations. For each subsurface community we estimate the degree to which it is influenced by homogeneous selection, variable selection, dispersal limitation, and homogenizing dispersal. Our analyses revealed that the relative influences of these ecological processes vary substantially across communities even within a geologic formation. We further identify environmental and spatial features associated with each ecological process, which allowed mapping of spatial variation in ecological-process-influences. The resulting maps provide a new lens through which ecological systems can be understood; in the subsurface system investigated here they revealed that the influence of variable selection was associated with the rate at which redox conditions change with subsurface depth. PMID:25983725

  13. Functional region prediction with a set of appropriate homologous sequences-an index for sequence selection by integrating structure and sequence information with spatial statistics

    PubMed Central

    2012-01-01

    Background The detection of conserved residue clusters on a protein structure is one of the effective strategies for the prediction of functional protein regions. Various methods, such as Evolutionary Trace, have been developed based on this strategy. In such approaches, the conserved residues are identified through comparisons of homologous amino acid sequences. Therefore, the selection of homologous sequences is a critical step. It is empirically known that a certain degree of sequence divergence in the set of homologous sequences is required for the identification of conserved residues. However, the development of a method to select homologous sequences appropriate for the identification of conserved residues has not been sufficiently addressed. An objective and general method to select appropriate homologous sequences is desired for the efficient prediction of functional regions. Results We have developed a novel index to select the sequences appropriate for the identification of conserved residues, and implemented the index within our method to predict the functional regions of a protein. The implementation of the index improved the performance of the functional region prediction. The index represents the degree of conserved residue clustering on the tertiary structure of the protein. For this purpose, the structure and sequence information were integrated within the index by the application of spatial statistics. Spatial statistics is a field of statistics in which not only the attributes but also the geometrical coordinates of the data are considered simultaneously. Higher degrees of clustering generate larger index scores. We adopted the set of homologous sequences with the highest index score, under the assumption that the best prediction accuracy is obtained when the degree of clustering is the maximum. The set of sequences selected by the index led to higher functional region prediction performance than the sets of sequences selected by other sequence-based methods. Conclusions Appropriate homologous sequences are selected automatically and objectively by the index. Such sequence selection improved the performance of functional region prediction. As far as we know, this is the first approach in which spatial statistics have been applied to protein analyses. Such integration of structure and sequence information would be useful for other bioinformatics problems. PMID:22643026

  14. Habitat quality of the coastal southeastern Bering Sea for juvenile flatfishes from the relationships between diet, body condition and prey availability

    NASA Astrophysics Data System (ADS)

    Yeung, Cynthia; Yang, Mei-Sun

    2017-01-01

    The distribution and body condition of juvenile northern rock sole (NRS), Lepidopsetta polyxystra, and yellowfin sole (YFS), Limanda aspera, were studied in relation to prey availability across the coastal shelf at the Alaska Peninsula boundary of the eastern Bering Sea (EBS) to assess spatial variability in habitat quality. Juveniles of ≤ 20 cm and adults of ≥ 30 cm total length were collected from bottom trawl catch samples at stations located 10 to 120 km from the Alaska Peninsula coast, and in bottom depths of 28 to 85 m. Stomach contents and stable isotopes of carbon and nitrogen from muscle tissue were analyzed to describe diet composition. The quantity and quality of prey did not significantly affect the distribution of juvenile NRS and YFS. Spatial mismatch between the diet composition and the infauna prey assemblage suggested that prey availability was not limiting across the area, allowing fish to select for prey, presumably to maximize net energy gain. The body condition of juvenile NRS was higher in the eastern section of the area (Bristol Bay) - where they shared spatial and dietary niches with juvenile YFS, than in the west section (Unimak Island) where juvenile YFS were largely absent. A difference in body condition suggests that habitat quality may be higher in Bristol Bay. For NRS, stomach contents and stable isotopes in muscle tissue indicated an ontogenetic diet shift from amphipods to polychaetes from juvenile to adult stages. In contrast, for YFS, amphipods seemed to remain the primary prey and polychaetes the least important prey from juvenile to adult stage. Given that the high prey availability found in this south coastal area of EBS extends to areas across the EBS shelf, favorable habitat for juvenile flatfishes should be extensive. However, much of this potential juvenile habitat is underutilized by NRS, which were mainly limited to Bristol Bay and the Alaska Peninsula, whereas YFS did extend north over 500 km from Bristol Bay along the inner shelf domain (≤ 50 m deep). Abiotic factors, particularly ocean currents and water temperature, may be more significant than prey availability in the spatial distribution of juveniles. Thus, changes in the hydrographic and thermal regime of the EBS are likely to impact juvenile flatfish distribution and habitat productivity.

  15. Spatial-mode storage in a gradient-echo memory

    NASA Astrophysics Data System (ADS)

    Higginbottom, D. B.; Sparkes, B. M.; Rancic, M.; Pinel, O.; Hosseini, M.; Lam, P. K.; Buchler, B. C.

    2012-08-01

    Three-level atomic gradient echo memory (Λ-GEM) is a proposed candidate for efficient quantum storage and for linear optical quantum computation with time-bin multiplexing [Hosseini , Nature (London)NATUAS0028-083610.1038/nature08325 461, 241 (2009)]. In this paper we investigate the spatial multimode properties of a Λ-GEM system. Using a high-speed triggered CCD, we demonstrate the storage of complex spatial modes and images. We also present an in-principle demonstration of spatial multiplexing by showing selective recall of spatial elements of a stored spin wave. Using our measurements, we consider the effect of diffusion within the atomic vapor and investigate its role in spatial decoherence. Our measurements allow us to quantify the spatial distortion due to both diffusion and inhomogeneous control field scattering and compare these to theoretical models.

  16. Overlapping MALDI-Mass Spectrometry Imaging for In-Parallel MS and MS/MS Data Acquisition without Sacrificing Spatial Resolution

    NASA Astrophysics Data System (ADS)

    Hansen, Rebecca L.; Lee, Young Jin

    2017-09-01

    Metabolomics experiments require chemical identifications, often through MS/MS analysis. In mass spectrometry imaging (MSI), this necessitates running several serial tissue sections or using a multiplex data acquisition method. We have previously developed a multiplex MSI method to obtain MS and MS/MS data in a single experiment to acquire more chemical information in less data acquisition time. In this method, each raster step is composed of several spiral steps and each spiral step is used for a separate scan event (e.g., MS or MS/MS). One main limitation of this method is the loss of spatial resolution as the number of spiral steps increases, limiting its applicability for high-spatial resolution MSI. In this work, we demonstrate multiplex MS imaging is possible without sacrificing spatial resolution by the use of overlapping spiral steps, instead of spatially separated spiral steps as used in the previous work. Significant amounts of matrix and analytes are still left after multiple spectral acquisitions, especially with nanoparticle matrices, so that high quality MS and MS/MS data can be obtained on virtually the same tissue spot. This method was then applied to visualize metabolites and acquire their MS/MS spectra in maize leaf cross-sections at 10 μm spatial resolution. [Figure not available: see fulltext.

  17. Spatial patterns of erosion in a bedrock gorge

    NASA Astrophysics Data System (ADS)

    Beer, Alexander. R.; Turowski, Jens M.; Kirchner, James W.

    2017-01-01

    Understanding the physical processes driving bedrock channel formation is essential for interpreting and predicting the evolution of mountain landscapes. Here we analyze bedrock erosion patterns measured at unprecedented spatial resolution (mm) over 2 years in a natural bedrock gorge. These spatial patterns show that local bedrock erosion rates depend on position in the channel cross section, height above the streambed, and orientation relative to the main streamflow and sediment path. These observations are consistent with the expected spatial distribution of impacting particles (the tools effect) and shielding by sediment on the bed (the cover effect). Vertical incision by bedrock abrasion averaged 1.5 mm/a, lateral abrasion averaged 0.4 mm/a, and downstream directed abrasion of flow obstacles averaged 2.6 mm/a. However, a single plucking event locally exceeded these rates by orders of magnitude (˜100 mm/a), and accounted for one third of the eroded volume in the studied gorge section over the 2 year study period. Hence, if plucking is spatially more frequent than we observed in this study period, it may contribute substantially to long-term erosion rates, even in the relatively massive bedrock at our study site. Our observations demonstrate the importance of bedrock channel morphology and the spatial distribution of moving and static sediment in determining local erosion rates.

  18. Examination of the 22C radius determination with interaction cross sections

    NASA Astrophysics Data System (ADS)

    Nagahisa, T.; Horiuchi, W.

    2018-05-01

    A nuclear radius of 22C is investigated with the total reaction cross sections at medium- to high-incident energies in order to resolve the radius puzzle in which two recent interaction cross-section measurements using 1H and 12C targets show the quite different radii. The cross sections of 22C are calculated consistently for these target nuclei within a reliable microscopic framework, the Glauber theory. To describe appropriately such a reaction involving a spatially extended nucleus, the multiple scattering processes within the Glauber theory are fully taken into account, that is, the multidimensional integration in the Glauber amplitude is evaluated using a Monte Carlo technique without recourse to the optical-limit approximation. We discuss the sensitivity of the spatially extended halo tail to the total reaction cross sections. The root-mean-square matter radius obtained in this study is consistent with that extracted from the recent cross-section measurement on 12C target. We show that the simultaneous reproduction of the two recent measured cross sections is not feasible within this framework.

  19. Relationships Among Peripheral and Central Electrophysiological Measures of Spatial and Spectral Selectivity and Speech Perception in Cochlear Implant Users

    PubMed Central

    Scheperle, Rachel A.; Abbas, Paul J.

    2014-01-01

    Objectives The ability to perceive speech is related to the listener’s ability to differentiate among frequencies (i.e., spectral resolution). Cochlear implant (CI) users exhibit variable speech-perception and spectral-resolution abilities, which can be attributed in part to the extent of electrode interactions at the periphery (i.e., spatial selectivity). However, electrophysiological measures of peripheral spatial selectivity have not been found to correlate with speech perception. The purpose of this study was to evaluate auditory processing at the periphery and cortex using both simple and spectrally complex stimuli to better understand the stages of neural processing underlying speech perception. The hypotheses were that (1) by more completely characterizing peripheral excitation patterns than in previous studies, significant correlations with measures of spectral selectivity and speech perception would be observed, (2) adding information about processing at a level central to the auditory nerve would account for additional variability in speech perception, and (3) responses elicited with spectrally complex stimuli would be more strongly correlated with speech perception than responses elicited with spectrally simple stimuli. Design Eleven adult CI users participated. Three experimental processor programs (MAPs) were created to vary the likelihood of electrode interactions within each participant. For each MAP, a subset of 7 of 22 intracochlear electrodes was activated: adjacent (MAP 1), every-other (MAP 2), or every third (MAP 3). Peripheral spatial selectivity was assessed using the electrically evoked compound action potential (ECAP) to obtain channel-interaction functions for all activated electrodes (13 functions total). Central processing was assessed by eliciting the auditory change complex (ACC) with both spatial (electrode pairs) and spectral (rippled noise) stimulus changes. Speech-perception measures included vowel-discrimination and the Bamford-Kowal-Bench Sentence-in-Noise (BKB-SIN) test. Spatial and spectral selectivity and speech perception were expected to be poorest with MAP 1 (closest electrode spacing) and best with MAP 3 (widest electrode spacing). Relationships among the electrophysiological and speech-perception measures were evaluated using mixed-model and simple linear regression analyses. Results All electrophysiological measures were significantly correlated with each other and with speech perception for the mixed-model analysis, which takes into account multiple measures per person (i.e. experimental MAPs). The ECAP measures were the best predictor of speech perception. In the simple linear regression analysis on MAP 3 data, only the cortical measures were significantly correlated with speech; spectral ACC amplitude was the strongest predictor. Conclusions The results suggest that both peripheral and central electrophysiological measures of spatial and spectral selectivity provide valuable information about speech perception. Clinically, it is often desirable to optimize performance for individual CI users. These results suggest that ECAP measures may be the most useful for within-subject applications, when multiple measures are performed to make decisions about processor options. They also suggest that if the goal is to compare performance across individuals based on single measure, then processing central to the auditory nerve (specifically, cortical measures of discriminability) should be considered. PMID:25658746

  20. Development of Visual Selection in 3- to 9-Month-Olds: Evidence from Saccades to Previously Ignored Locations

    ERIC Educational Resources Information Center

    Amso, Dima; Johnson, Scott P.

    2008-01-01

    We examined changes in the efficiency of visual selection over the first postnatal year with an adapted version of a "spatial negative priming" paradigm. In this task, when a previously ignored location becomes the target to be selected, responses to it are impaired, providing a measure of visual selection. Oculomotor latencies to target selection…

  1. Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias

    PubMed Central

    Sengmany, K

    2015-01-01

    The metabotropic glutamate receptor subtype 5 (mGlu5) is a family C GPCR that has been implicated in various neuronal processes and, consequently, in several CNS disorders. Over the past few decades, GPCR‐based drug discovery, including that for mGlu5 receptors, has turned considerable attention to targeting allosteric binding sites. Modulation of endogenous agonists by allosteric ligands offers the advantages of spatial and temporal fine‐tuning of receptor activity, increased selectivity and reduced adverse effects with the potential to elicit improved clinical outcomes. Further, with greater appreciation of the multifaceted nature of the transduction of mGlu5 receptor signalling, it is increasingly apparent that drug discovery must take into consideration unique receptor conformations and the potential for stimulus‐bias. This novel paradigm proposes that different ligands may differentially modulate distinct signalling pathways arising from the same receptor. We review our current understanding of the complexities of mGlu5 receptor signalling and regulation, and how these relate to allosteric ligands. Ultimately, a deeper appreciation of these relationships will provide the foundation for targeted drug design of compounds with increased selectivity, not only for the desired receptor but also for the desired signalling outcome from the receptor. Linked Articles This article is part of a themed section on Molecular Pharmacology of G Protein‐Coupled Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v173.20/issuetoc PMID:26276909

  2. Analytical performance of a versatile laboratory microscopic X-ray fluorescence system for metal uptake studies on argillaceous rocks

    NASA Astrophysics Data System (ADS)

    Gergely, Felicián; Osán, János; Szabó, B. Katalin; Török, Szabina

    2016-02-01

    Laboratory-scale microscopic X-ray fluorescence (micro-XRF) plays an increasingly important role in various fields where multielemental investigations of samples are indispensable. In case of geological samples, the reasonable detection limits (LOD) and spatial resolutions are necessary to identify the trace element content in microcrystalline level. The present study focuses on the analytical performance of a versatile laboratory-scale micro-XRF system with various options of X-ray sources and detectors to find the optimal experimental configuration in terms of sensitivities and LOD for selected elements in loaded petrographic thin sections. The method was tested for sorption studies involving thin sections prepared from cores of Boda Claystone Formation, which is a potential site for a high-level radioactive waste repository. Loaded ions in the sorption measurements were Cs(I) and Ni(II) chemically representing fission and corrosion products. Based on the collected elemental maps, the correlation between the elements representative of main rock components and the selected loaded ion was studied. For the elements of interest, Cs(I) and Ni(II) low-power iMOXS source with polycapillary and silicon drift detector was found to be the best configuration to reach the optimal LOD values. Laboratory micro-XRF was excellent to identify the responsible key minerals for the uptake of Cs(I). In case of nickel, careful corrections were needed because of the relatively high Ca content of the rock samples. The results were compared to synchrotron radiation micro-XRF.

  3. Silicon oxide nanoparticles doped PQ-PMMA for volume holographic imaging filters.

    PubMed

    Luo, Yuan; Russo, Juan M; Kostuk, Raymond K; Barbastathis, George

    2010-04-15

    Holographic imaging filters are required to have high Bragg selectivity, namely, narrow angular and spectral bandwidth, to obtain spatial-spectral information within a three-dimensional object. In this Letter, we present the design of holographic imaging filters formed using silicon oxide nanoparticles (nano-SiO(2)) in phenanthrenquinone-poly(methyl methacrylate) (PQ-PMMA) polymer recording material. This combination offers greater Bragg selectivity and increases the diffraction efficiency of holographic filters. The holographic filters with optimized ratio of nano-SiO(2) in PQ-PMMA can significantly improve the performance of Bragg selectivity and diffraction efficiency by 53% and 16%, respectively. We present experimental results and data analysis demonstrating this technique in use for holographic spatial-spectral imaging filters.

  4. Visual-Spatial Thinking in Hypertexts.

    ERIC Educational Resources Information Center

    Johnson-Sheehan, Richard; Baehr, Craig

    2001-01-01

    Explores what it means to think visually and spatially in hypertexts and how users react and maneuver in real and virtual three-dimensional spaces. Offers four principles of visual thinking that can be applied when developing hypertexts. Applies these principles to actual hypertexts, demonstrating how selectivity, fixation, depth discernment, and…

  5. Optimal attributes for the object based detection of giant reed in riparian habitats: A comparative study between Airborne High Spatial Resolution and WorldView-2 imagery

    NASA Astrophysics Data System (ADS)

    Fernandes, Maria Rosário; Aguiar, Francisca C.; Silva, João M. N.; Ferreira, Maria Teresa; Pereira, José M. C.

    2014-10-01

    Giant reed is an aggressive invasive plant of riparian ecosystems in many sub-tropical and warm-temperate regions, including Mediterranean Europe. In this study we tested a set of geometric, spectral and textural attributes in an object based image analysis (OBIA) approach to map giant reed invasions in riparian habitats. Bagging Classification and Regression Tree were used to select the optimal attributes and to build the classification rules sets. Mapping accuracy was performed using landscape metrics and the Kappa coefficient to compare the topographical and geometric similarity between the giant reed patches obtained with the OBIA map and with a validation map derived from on-screen digitizing. The methodology was applied in two high spatial resolution images: an airborne multispectral imagery and the newly WorldView-2 imagery. A temporal coverage of the airborne multispectral images was radiometrically calibrated with the IR-Mad transformation and used to assess the influence of the phenological variability of the invader. We found that optimal attributes for giant reed OBIA detection are a combination of spectral, geometric and textural information, with different scoring selection depending on the spectral and spatial characteristics of the imagery. WorldView-2 showed higher mapping accuracy (Kappa coefficient of 77%) and spectral attributes, including the newly yellow band, were preferentially selected, although a tendency to overestimate the total invaded area, due to the low spatial resolution (2 m of pixel size vs. 50 cm) was observed. When airborne images were used, geometric attributes were primarily selected and a higher spatial detail of the invasive patches was obtained, due to the higher spatial resolution. However, in highly heterogeneous landscapes, the low spectral resolution of the airborne images (4 bands instead of the 8 of WorldView-2) reduces the capability to detect giant reed patches. Giant reed displays peculiar spectral and geometric traits, at leaf, canopy and stand level, which makes the OBIA approach a very suitable technique for management purposes.

  6. Application of Remote Sensing and GIS in Landfill (waste Disposal) Site Selection and Environmental Impacts Assessment around Mysore City, Karnataka, India

    NASA Astrophysics Data System (ADS)

    Basavarajappa, T. H.

    2012-07-01

    Landfill site selection is a complex process involving geological, hydrological, environmental and technical parameters as well as government regulations. As such, it requires the processing of a good amount of geospatial data. Landfill site selection techniques have been analyzed for identifying their suitability. Application of Geographic Information System (GIS) is suitable to find best locations for such installations which use multiple criteria analysis. The use of Artificial intelligence methods, such as expert systems, can also be very helpful in solid waste planning and management. The waste disposal and its pollution around major cities in Karnataka are important problems affecting the environment. The Mysore is one of the major cities in Karnataka. The landfill site selection is the best way to control of pollution from any region. The main aim is to develop geographic information system to study the Landuse/ Landcover, natural drainage system, water bodies, and extents of villages around Mysore city, transportation, topography, geomorphology, lithology, structures, vegetation and forest information for landfill site selection. GIS combines spatial data (maps, aerial photographs, and satellite images) with quantitative, qualitative, and descriptive information database, which can support a wide range of spatial queries. For the Site Selection of an industrial waste and normal daily urban waste of a city town or a village, combining GIS with Analytical Hierarchy Process (AHP) will be more appropriate. This method is innovative because it establishes general indices to quantify overall environmental impact as well as individual indices for specific environmental components (i.e. surface water, groundwater, atmosphere, soil and human health). Since this method requires processing large quantities of spatial data. To automate the processes of establishing composite evaluation criteria, performing multiple criteria analysis and carrying out spatial clustering a suitable methodology was developed. The feasibility of site selection in the study area based on different criteria was used to obtain the layered data by integrating Remote Sensing and GIS. This methodology is suitable for all practical applications in other cities, also.

  7. Tigers on trails: occupancy modeling for cluster sampling.

    PubMed

    Hines, J E; Nichols, J D; Royle, J A; MacKenzie, D I; Gopalaswamy, A M; Kumar, N Samba; Karanth, K U

    2010-07-01

    Occupancy modeling focuses on inference about the distribution of organisms over space, using temporal or spatial replication to allow inference about the detection process. Inference based on spatial replication strictly requires that replicates be selected randomly and with replacement, but the importance of these design requirements is not well understood. This paper focuses on an increasingly popular sampling design based on spatial replicates that are not selected randomly and that are expected to exhibit Markovian dependence. We develop two new occupancy models for data collected under this sort of design, one based on an underlying Markov model for spatial dependence and the other based on a trap response model with Markovian detections. We then simulated data under the model for Markovian spatial dependence and fit the data to standard occupancy models and to the two new models. Bias of occupancy estimates was substantial for the standard models, smaller for the new trap response model, and negligible for the new spatial process model. We also fit these models to data from a large-scale tiger occupancy survey recently conducted in Karnataka State, southwestern India. In addition to providing evidence of a positive relationship between tiger occupancy and habitat, model selection statistics and estimates strongly supported the use of the model with Markovian spatial dependence. This new model provides another tool for the decomposition of the detection process, which is sometimes needed for proper estimation and which may also permit interesting biological inferences. In addition to designs employing spatial replication, we note the likely existence of temporal Markovian dependence in many designs using temporal replication. The models developed here will be useful either directly, or with minor extensions, for these designs as well. We believe that these new models represent important additions to the suite of modeling tools now available for occupancy estimation in conservation monitoring. More generally, this work represents a contribution to the topic of cluster sampling for situations in which there is a need for specific modeling (e.g., reflecting dependence) for the distribution of the variable(s) of interest among subunits.

  8. Attention to local and global levels of hierarchical Navon figures affects rapid scene categorization.

    PubMed

    Brand, John; Johnson, Aaron P

    2014-01-01

    In four experiments, we investigated how attention to local and global levels of hierarchical Navon figures affected the selection of diagnostic spatial scale information used in scene categorization. We explored this issue by asking observers to classify hybrid images (i.e., images that contain low spatial frequency (LSF) content of one image, and high spatial frequency (HSF) content from a second image) immediately following global and local Navon tasks. Hybrid images can be classified according to either their LSF, or HSF content; thus, making them ideal for investigating diagnostic spatial scale preference. Although observers were sensitive to both spatial scales (Experiment 1), they overwhelmingly preferred to classify hybrids based on LSF content (Experiment 2). In Experiment 3, we demonstrated that LSF based hybrid categorization was faster following global Navon tasks, suggesting that LSF processing associated with global Navon tasks primed the selection of LSFs in hybrid images. In Experiment 4, replicating Experiment 3 but suppressing the LSF information in Navon letters by contrast balancing the stimuli examined this hypothesis. Similar to Experiment 3, observers preferred to classify hybrids based on LSF content; however and in contrast, LSF based hybrid categorization was slower following global than local Navon tasks.

  9. Spatial evolutionary games with weak selection.

    PubMed

    Nanda, Mridu; Durrett, Richard

    2017-06-06

    Recently, a rigorous mathematical theory has been developed for spatial games with weak selection, i.e., when the payoff differences between strategies are small. The key to the analysis is that when space and time are suitably rescaled, the spatial model converges to the solution of a partial differential equation (PDE). This approach can be used to analyze all [Formula: see text] games, but there are a number of [Formula: see text] games for which the behavior of the limiting PDE is not known. In this paper, we give rules for determining the behavior of a large class of [Formula: see text] games and check their validity using simulation. In words, the effect of space is equivalent to making changes in the payoff matrix, and once this is done, the behavior of the spatial game can be predicted from the behavior of the replicator equation for the modified game. We say predicted here because in some cases the behavior of the spatial game is different from that of the replicator equation for the modified game. For example, if a rock-paper-scissors game has a replicator equation that spirals out to the boundary, space stabilizes the system and produces an equilibrium.

  10. Spatial evolutionary games with weak selection

    PubMed Central

    Nanda, Mridu; Durrett, Richard

    2017-01-01

    Recently, a rigorous mathematical theory has been developed for spatial games with weak selection, i.e., when the payoff differences between strategies are small. The key to the analysis is that when space and time are suitably rescaled, the spatial model converges to the solution of a partial differential equation (PDE). This approach can be used to analyze all 2×2 games, but there are a number of 3×3 games for which the behavior of the limiting PDE is not known. In this paper, we give rules for determining the behavior of a large class of 3×3 games and check their validity using simulation. In words, the effect of space is equivalent to making changes in the payoff matrix, and once this is done, the behavior of the spatial game can be predicted from the behavior of the replicator equation for the modified game. We say predicted here because in some cases the behavior of the spatial game is different from that of the replicator equation for the modified game. For example, if a rock–paper–scissors game has a replicator equation that spirals out to the boundary, space stabilizes the system and produces an equilibrium. PMID:28533405

  11. Attention to local and global levels of hierarchical Navon figures affects rapid scene categorization

    PubMed Central

    Brand, John; Johnson, Aaron P.

    2014-01-01

    In four experiments, we investigated how attention to local and global levels of hierarchical Navon figures affected the selection of diagnostic spatial scale information used in scene categorization. We explored this issue by asking observers to classify hybrid images (i.e., images that contain low spatial frequency (LSF) content of one image, and high spatial frequency (HSF) content from a second image) immediately following global and local Navon tasks. Hybrid images can be classified according to either their LSF, or HSF content; thus, making them ideal for investigating diagnostic spatial scale preference. Although observers were sensitive to both spatial scales (Experiment 1), they overwhelmingly preferred to classify hybrids based on LSF content (Experiment 2). In Experiment 3, we demonstrated that LSF based hybrid categorization was faster following global Navon tasks, suggesting that LSF processing associated with global Navon tasks primed the selection of LSFs in hybrid images. In Experiment 4, replicating Experiment 3 but suppressing the LSF information in Navon letters by contrast balancing the stimuli examined this hypothesis. Similar to Experiment 3, observers preferred to classify hybrids based on LSF content; however and in contrast, LSF based hybrid categorization was slower following global than local Navon tasks. PMID:25520675

  12. Object orientation affects spatial language comprehension.

    PubMed

    Burigo, Michele; Sacchi, Simona

    2013-01-01

    Typical spatial descriptions, such as "The car is in front of the house," describe the position of a located object (LO; e.g., the car) in space relative to a reference object (RO) whose location is known (e.g., the house). The orientation of the RO affects spatial language comprehension via the reference frame selection process. However, the effects of the LO's orientation on spatial language have not received great attention. This study explores whether the pure geometric information of the LO (e.g., its orientation) affects spatial language comprehension using placing and production tasks. Our results suggest that the orientation of the LO influences spatial language comprehension even in the absence of functional relationships. Copyright © 2013 Cognitive Science Society, Inc.

  13. Examining spatial patterns of selection and use for an altered predator guild

    USGS Publications Warehouse

    Organ, John F.; Mumma, Matthew; Holbrook, Joseph D.; Rayl, Nathaniel D.; Zieminski, Christopher J.; Fuller, Todd K.; Mahoney, Shane P.; Waits, Lisette P.

    2017-01-01

    Anthropogenic disturbances have altered species’ distributions potentially impacting interspecific interactions. Interference competition is when one species denies a competing species access to a resource. One mechanism of interference competition is aggression, which can result in altered space-use of a subordinate species due to the threat of harm, otherwise known as a ‘landscape of fear’. Alternatively, subordinates might outcompete dominant species in resource-poor environments via a superior ability to extract resources. Our goal was to evaluate spatial predictions of the ‘landscape of fear’ hypothesis for a carnivore guild in Newfoundland, Canada, where coyotes recently immigrated. Native Newfoundland carnivores include red foxes, Canada lynx, and black bears. We predicted foxes and lynx would avoid coyotes because of their larger size and similar dietary niches. We used scat-detecting dogs and genetic techniques to locate and identify predator scats. We then built resource selection functions and tested for avoidance by incorporating predicted values of selection for the alternative species into the best supported models of each species. We found multiple negative relationships, but notably did not find avoidance by foxes of areas selected by coyotes. While we did find that lynx avoided coyotes, we also found a reciprocal relationship. The observed patterns suggest spatial partitioning and not coyote avoidance, although avoidance could still be occurring at different spatial or temporal scales. Furthermore, Newfoundland’s harsh climate and poor soils may swing the pendulum of interspecific interactions from interference competition to exploitative competition, where subordinates outcompete dominant competitors through a superior ability to extract resources.

  14. Increased genomic prediction accuracy in wheat breeding through spatial adjustment of field trial data.

    PubMed

    Lado, Bettina; Matus, Ivan; Rodríguez, Alejandra; Inostroza, Luis; Poland, Jesse; Belzile, François; del Pozo, Alejandro; Quincke, Martín; Castro, Marina; von Zitzewitz, Jarislav

    2013-12-09

    In crop breeding, the interest of predicting the performance of candidate cultivars in the field has increased due to recent advances in molecular breeding technologies. However, the complexity of the wheat genome presents some challenges for applying new technologies in molecular marker identification with next-generation sequencing. We applied genotyping-by-sequencing, a recently developed method to identify single-nucleotide polymorphisms, in the genomes of 384 wheat (Triticum aestivum) genotypes that were field tested under three different water regimes in Mediterranean climatic conditions: rain-fed only, mild water stress, and fully irrigated. We identified 102,324 single-nucleotide polymorphisms in these genotypes, and the phenotypic data were used to train and test genomic selection models intended to predict yield, thousand-kernel weight, number of kernels per spike, and heading date. Phenotypic data showed marked spatial variation. Therefore, different models were tested to correct the trends observed in the field. A mixed-model using moving-means as a covariate was found to best fit the data. When we applied the genomic selection models, the accuracy of predicted traits increased with spatial adjustment. Multiple genomic selection models were tested, and a Gaussian kernel model was determined to give the highest accuracy. The best predictions between environments were obtained when data from different years were used to train the model. Our results confirm that genotyping-by-sequencing is an effective tool to obtain genome-wide information for crops with complex genomes, that these data are efficient for predicting traits, and that correction of spatial variation is a crucial ingredient to increase prediction accuracy in genomic selection models.

  15. Examining spatial patterns of selection and use for an altered predator guild.

    PubMed

    Mumma, Matthew A; Holbrook, Joseph D; Rayl, Nathaniel D; Zieminski, Christopher J; Fuller, Todd K; Organ, John F; Mahoney, Shane P; Waits, Lisette P

    2017-12-01

    Anthropogenic disturbances have altered species' distributions potentially impacting interspecific interactions. Interference competition is when one species denies a competing species access to a resource. One mechanism of interference competition is aggression, which can result in altered space-use of a subordinate species due to the threat of harm, otherwise known as a 'landscape of fear'. Alternatively, subordinates might outcompete dominant species in resource-poor environments via a superior ability to extract resources. Our goal was to evaluate spatial predictions of the 'landscape of fear' hypothesis for a carnivore guild in Newfoundland, Canada, where coyotes recently immigrated. Native Newfoundland carnivores include red foxes, Canada lynx, and black bears. We predicted foxes and lynx would avoid coyotes because of their larger size and similar dietary niches. We used scat-detecting dogs and genetic techniques to locate and identify predator scats. We then built resource selection functions and tested for avoidance by incorporating predicted values of selection for the alternative species into the best supported models of each species. We found multiple negative relationships, but notably did not find avoidance by foxes of areas selected by coyotes. While we did find that lynx avoided coyotes, we also found a reciprocal relationship. The observed patterns suggest spatial partitioning and not coyote avoidance, although avoidance could still be occurring at different spatial or temporal scales. Furthermore, Newfoundland's harsh climate and poor soils may swing the pendulum of interspecific interactions from interference competition to exploitative competition, where subordinates outcompete dominant competitors through a superior ability to extract resources.

  16. Age-related change in renal corticomedullary differentiation: evaluation with noncontrast-enhanced steady-state free precession (SSFP) MRI with spatially selective inversion pulse using variable inversion time.

    PubMed

    Noda, Yasufumi; Kanki, Akihiko; Yamamoto, Akira; Higashi, Hiroki; Tanimoto, Daigo; Sato, Tomohiro; Higaki, Atsushi; Tamada, Tsutomu; Ito, Katsuyoshi

    2014-07-01

    To evaluate age-related change in renal corticomedullary differentiation and renal cortical thickness by means of noncontrast-enhanced steady-state free precession (SSFP) magnetic resonance imaging (MRI) with spatially selective inversion recovery (IR) pulse. The Institutional Review Board of our hospital approved this retrospective study and patient informed consent was waived. This study included 48 patients without renal diseases who underwent noncontrast-enhanced SSFP MRI with spatially selective IR pulse using variable inversion times (TIs) (700-1500 msec). The signal intensity of renal cortex and medulla were measured to calculate renal corticomedullary contrast ratio. Additionally, renal cortical thickness was measured. The renal corticomedullary junction was clearly depicted in all patients. The mean cortical thickness was 3.9 ± 0.83 mm. The mean corticomedullary contrast ratio was 4.7 ± 1.4. There was a negative correlation between optimal TI for the best visualization of renal corticomedullary differentiation and age (r = -0.378; P = 0.001). However, there was no significant correlation between renal corticomedullary contrast ratio and age (r = 0.187; P = 0.20). Similarly, no significant correlation was observed between renal cortical thickness and age (r = 0.054; P = 0.712). In the normal kidney, noncontrast-enhanced SSFP MRI with spatially selective IR pulse can be used to assess renal corticomedullary differentiation and cortical thickness without the influence of aging, although optimal TI values for the best visualization of renal corticomedullary junction were shortened with aging. © 2013 Wiley Periodicals, Inc.

  17. Analysis of Multi-Criteria Evaluation Method of Landfill Site Selection for Municipal Solid Waste Management

    NASA Astrophysics Data System (ADS)

    Mohammed, Habiba Ibrahim; Majid, Zulkepli; Yusof, Norhakim Bin; Bello Yamusa, Yamusa

    2018-03-01

    Landfilling remains the most common systematic technique of solid waste disposal in most of the developed and developing countries. Finding a suitable site for landfill is a very challenging task. Landfill site selection process aims to provide suitable areas that will protect the environment and public health from pollution and hazards. Therefore, various factors such as environmental, physical, socio-economic, and geological criteria must be considered before siting any landfill. This makes the site selection process vigorous and tedious because it involves the processing of large amount of spatial data, rules and regulations from different agencies and also policy from decision makers. This allows the incorporation of conflicting objectives and decision maker preferences into spatial decision models. This paper particularly analyzes the multi-criteria evaluation (MCE) method of landfill site selection for solid waste management by means of literature reviews and surveys. The study will help the decision makers and waste management authorities to choose the most effective method when considering landfill site selection.

  18. Local diffusion and diffusion-T2 distribution measurements in porous media

    NASA Astrophysics Data System (ADS)

    Vashaee, S.; Newling, B.; MacMillan, B.; Marica, F.; Li, M.; Balcom, B. J.

    2017-05-01

    Slice-selective pulsed field gradient (PFG) and PFG-T2 measurements are developed to measure spatially-resolved molecular diffusion and diffusion-T2 distributions. A spatially selective adiabatic inversion pulse was employed for slice-selection. The slice-selective pulse is able to select a coarse slice, on the order of 1 cm, at an arbitrary position in the sample. The new method can be employed to characterize oil-water mixtures in porous media. The new technique has an inherent sensitivity advantage over phase encoding imaging based methods due to signal being localized from a thick slice. The method will be advantageous for magnetic resonance of porous media at low field where sensitivity is problematic. Experimental CPMG data, following PFG diffusion measurement, were compromised by a transient ΔB0(t) field offset. The off resonance effects of ΔB0(t) were examined by simulation. The ΔB0 offset artifact in D-T2 distribution measurements may be avoided by employing real data, instead of magnitude data.

  19. Prefrontal spatial working memory network predicts animal's decision making in a free choice saccade task.

    PubMed

    Mochizuki, Kei; Funahashi, Shintaro

    2016-01-01

    While neurons in the lateral prefrontal cortex (PFC) encode spatial information during the performance of working memory tasks, they are also known to participate in subjective behavior such as spatial attention and action selection. In the present study, we analyzed the activity of primate PFC neurons during the performance of a free choice memory-guided saccade task in which the monkeys needed to choose a saccade direction by themselves. In trials when the receptive field location was subsequently chosen by the animal, PFC neurons with spatially selective visual response started to show greater activation before cue onset. This result suggests that the fluctuation of firing before cue presentation prematurely biased the representation of a certain spatial location and eventually encouraged the subsequent choice of that location. In addition, modulation of the activity by the animal's choice was observed only in neurons with high sustainability of activation and was also dependent on the spatial configuration of the visual cues. These findings were consistent with known characteristics of PFC neurons in information maintenance in spatial working memory function. These results suggest that precue fluctuation of spatial representation was shared and enhanced through the working memory network in the PFC and could finally influence the animal's free choice of saccade direction. The present study revealed that the PFC plays an important role in decision making in a free choice condition and that the dynamics of decision making are constrained by the network architecture embedded in this cortical area. Copyright © 2016 the American Physiological Society.

  20. Ongoing niche differentiation under high gene flow in a polymorphic brackish water threespine stickleback (Gasterosteus aculeatus) population.

    PubMed

    Østbye, Kjartan; Taugbøl, Annette; Ravinet, Mark; Harrod, Chris; Pettersen, Ruben Alexander; Bernatchez, Louis; Vøllestad, Leif Asbjørn

    2018-02-05

    Marine threespine sticklebacks colonized and adapted to brackish and freshwater environments since the last Pleistocene glacial. Throughout the Holarctic, three lateral plate morphs are observed; the low, partial and completely plated morph. We test if the three plate morphs in the brackish water Lake Engervann, Norway, differ in body size, trophic morphology (gill raker number and length), niche (stable isotopes; δ 15 N, δ 13 C, and parasites (Theristina gasterostei, Trematoda spp.)), genetic structure (microsatellites) and the lateral-plate encoding Stn382 (Ectodysplasin) gene. We examine differences temporally (autumn 2006/spring 2007) and spatially (upper/lower sections of the lake - reflecting low versus high salinity). All morphs belonged to one gene pool. The complete morph was larger than the low plated, with the partial morph intermediate. The number of lateral plates ranged 8-71, with means of 64.2 for complete, 40.3 for partial, and 14.9 for low plated morph. Stickleback δ 15 N was higher in the lower lake section, while δ 13 C was higher in the upper section. Stickleback isotopic values were greater in autumn. The low plated morph had larger variances in δ 15 N and δ 13 C than the other morphs. Sticklebacks in the upper section had more T. gasterostei than in the lower section which had more Trematoda spp. Sticklebacks had less T. gasterostei, but more Trematoda spp. in autumn than spring. Sticklebacks with few and short rakers had more T. gasterostei, while sticklebacks with longer rakers had more Trematoda. spp. Stickleback with higher δ 15 N values had more T. gasterostei, while sticklebacks with higher δ 15 N and δ 13 C values had more Trematoda spp. The low plated morph had fewer Trematoda spp. than other morphs. Trait-ecology associations may imply that the three lateral plate morphs in the brackish water lagoon of Lake Engervann are experiencing ongoing divergent selection for niche and migratory life history strategies under high gene flow. As such, the brackish water zone may generally act as a generator of genomic diversity to be selected upon in the different environments where threespine sticklebacks can live.

  1. Spatial light modulator array with heat minimization and image enhancement features

    DOEpatents

    Jain, Kanti [Briarcliff Manor, NY; Sweatt, William C [Albuquerque, NM; Zemel, Marc [New Rochelle, NY

    2007-01-30

    An enhanced spatial light modulator (ESLM) array, a microelectronics patterning system and a projection display system using such an ESLM for heat-minimization and resolution enhancement during imaging, and the method for fabricating such an ESLM array. The ESLM array includes, in each individual pixel element, a small pixel mirror (reflective region) and a much larger pixel surround. Each pixel surround includes diffraction-grating regions and resolution-enhancement regions. During imaging, a selected pixel mirror reflects a selected-pixel beamlet into the capture angle of a projection lens, while the diffraction grating of the pixel surround redirects heat-producing unused radiation away from the projection lens. The resolution-enhancement regions of selected pixels provide phase shifts that increase effective modulation-transfer function in imaging. All of the non-selected pixel surrounds redirect all radiation energy away from the projection lens. All elements of the ESLM are fabricated by deposition, patterning, etching and other microelectronic process technologies.

  2. Amygdala neural activity reflects spatial attention towards stimuli promising reward or threatening punishment

    PubMed Central

    Peck, Christopher J; Salzman, C Daniel

    2014-01-01

    Humans and other animals routinely identify and attend to sensory stimuli so as to rapidly acquire rewards or avoid aversive experiences. Emotional arousal, a process mediated by the amygdala, can enhance attention to stimuli in a non-spatial manner. However, amygdala neural activity was recently shown to encode spatial information about reward-predictive stimuli, and to correlate with spatial attention allocation. If representing the motivational significance of sensory stimuli within a spatial framework reflects a general principle of amygdala function, then spatially selective neural responses should also be elicited by sensory stimuli threatening aversive events. Recordings from amygdala neurons were therefore obtained while monkeys directed spatial attention towards stimuli promising reward or threatening punishment. Neural responses encoded spatial information similarly for stimuli associated with both valences of reinforcement, and responses reflected spatial attention allocation. The amygdala therefore may act to enhance spatial attention to sensory stimuli associated with rewarding or aversive experiences. DOI: http://dx.doi.org/10.7554/eLife.04478.001 PMID:25358090

  3. Geostatistics for spatial genetic structures: study of wild populations of perennial ryegrass.

    PubMed

    Monestiez, P; Goulard, M; Charmet, G

    1994-04-01

    Methods based on geostatistics were applied to quantitative traits of agricultural interest measured on a collection of 547 wild populations of perennial ryegrass in France. The mathematical background of these methods, which resembles spatial autocorrelation analysis, is briefly described. When a single variable is studied, the spatial structure analysis is similar to spatial autocorrelation analysis, and a spatial prediction method, called "kriging", gives a filtered map of the spatial pattern over all the sampled area. When complex interactions of agronomic traits with different evaluation sites define a multivariate structure for the spatial analysis, geostatistical methods allow the spatial variations to be broken down into two main spatial structures with ranges of 120 km and 300 km, respectively. The predicted maps that corresponded to each range were interpreted as a result of the isolation-by-distance model and as a consequence of selection by environmental factors. Practical collecting methodology for breeders may be derived from such spatial structures.

  4. Precoded spatial multiplexing MIMO system with spatial component interleaver.

    PubMed

    Gao, Xiang; Wu, Zhanji

    In this paper, the performance of precoded bit-interleaved coded modulation (BICM) spatial multiplexing multiple-input multiple-output (MIMO) system with spatial component interleaver is investigated. For the ideal precoded spatial multiplexing MIMO system with spatial component interleaver based on singular value decomposition (SVD) of the MIMO channel, the average pairwise error probability (PEP) of coded bits is derived. Based on the PEP analysis, the optimum spatial Q-component interleaver design criterion is provided to achieve the minimum error probability. For the limited feedback precoded proposed scheme with linear zero forcing (ZF) receiver, in order to minimize a bound on the average probability of a symbol vector error, a novel effective signal-to-noise ratio (SNR)-based precoding matrix selection criterion and a simplified criterion are proposed. Based on the average mutual information (AMI)-maximization criterion, the optimal constellation rotation angles are investigated. Simulation results indicate that the optimized spatial multiplexing MIMO system with spatial component interleaver can achieve significant performance advantages compared to the conventional spatial multiplexing MIMO system.

  5. Lidar Investigation of Aerosol Pollution Distribution near a Coal Power Plant

    NASA Technical Reports Server (NTRS)

    Mitsev, TS.; Kolarov, G.

    1992-01-01

    Using aerosol lidars with high spatial and temporal resolution with the possibility of real-time data interpretation can solve a large number of ecological problems related to the aerosol-field distribution and variation and the structure of convective flows. Significantly less expensive specialized lidars are used in studying anthropogenic aerosols in the planetary boundary layer. Here, we present results of lidar measurements of the mass-concentration field around a coal-fired power plant with intensive local aerosol sources. We studied the pollution evolution as a function of the emission dynamics and the presence of retaining layers. The technique used incorporates complex analysis of three types of lidar mapping: horizontal map of the aerosol field, vertical cross-section map, and a series of profiles along a selected path. The lidar-sounding cycle was performed for the time of atmosphere's quasi-stationarity.

  6. Zn(II)-coordination modulated ligand photophysical processes – the development of fluorescent indicators for imaging biological Zn(II) ions

    PubMed Central

    Yuan, Zhao; Simmons, J. Tyler; Sreenath, Kesavapillai

    2014-01-01

    Molecular photophysics and metal coordination chemistry are the two fundamental pillars that support the development of fluorescent cation indicators. In this article, we describe how Zn(II)-coordination alters various ligand-centered photophysical processes that are pertinent to developing Zn(II) indicators. The main aim is to show how small organic Zn(II) indicators work under the constraints of specific requirements, including Zn(II) detection range, photophysical requirements such as excitation energy and emission color, temporal and spatial resolutions in a heterogeneous intracellular environment, and fluorescence response selectivity between similar cations such as Zn(II) and Cd(II). In the last section, the biological questions that fluorescent Zn(II) indicators help to answer are described, which have been motivating and challenging this field of research. PMID:25071933

  7. High precision mapping of kidney stones using μ-IR spectroscopy to determine urinary lithogenesis.

    PubMed

    Blanco, Francisco; Ortiz-Alías, Pilar; López-Mesas, Montserrat; Valiente, Manuel

    2015-06-01

    Evolution of urinary lithiasis is determined by the metabolism and life-style of the related patient. The appropriate classification of the stone is mandatory for the identification of the lithogenic process. In this study, cros-sections from a single stone of each of the most frequent urolithiasis types (calcium oxalate mono and dihydrate and carbonate apatite) have been selected and imaged using IR microspectroscopy. Moreover, the use of high definition sFTIR (synchrotron source) has revealed hidden information to the conventional FTIR. This work has demonstrated that minor components become key factors on the description of the stages of stone formation. Intensity map for COM (1630 cm(-1) peak). The high spatial definition achieved is key for the precise description of the kidney stone history. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Segmentation and clustering as complementary sources of information

    NASA Astrophysics Data System (ADS)

    Dale, Michael B.; Allison, Lloyd; Dale, Patricia E. R.

    2007-03-01

    This paper examines the effects of using a segmentation method to identify change-points or edges in vegetation. It identifies coherence (spatial or temporal) in place of unconstrained clustering. The segmentation method involves change-point detection along a sequence of observations so that each cluster formed is composed of adjacent samples; this is a form of constrained clustering. The protocol identifies one or more models, one for each section identified, and the quality of each is assessed using a minimum message length criterion, which provides a rational basis for selecting an appropriate model. Although the segmentation is less efficient than clustering, it does provide other information because it incorporates textural similarity as well as homogeneity. In addition it can be useful in determining various scales of variation that may apply to the data, providing a general method of small-scale pattern analysis.

  9. Relating Dopaminergic and Cholinergic Polymorphisms to Spatial Attention in Infancy

    ERIC Educational Resources Information Center

    Markant, Julie; Cicchetti, Dante; Hetzel, Susan; Thomas, Kathleen M.

    2014-01-01

    Early selective attention skills are a crucial building block for cognitive development, as attention orienting serves as a primary means by which infants interact with and learn from the environment. Although several studies have examined infants' attention orienting using the spatial cueing task, relatively few studies have examined…

  10. Assessment of Learning Outcomes: The Example of Spatial Analysis at Bowling Green State University

    ERIC Educational Resources Information Center

    Smith, Bruce W.; Zhou, Yu

    2005-01-01

    This article provides an overview of a developing approach to assessing selected undergraduate geography courses at Bowling Green State University (BGSU). The assessment focuses on the students' skills in collecting, integrating, analysing, displaying, and communicating spatial information and data sources using mapping and geographic information…

  11. Interurban Systems and Regional Economic Development, Resource Paper No. 26.

    ERIC Educational Resources Information Center

    Stohr, Walter B.

    This resource paper on economic geography is part of a series designed to supplement undergraduate geography courses. It interprets regional economic development in terms of geographic spatial patterns of production, income, and physical or economic distance. Chapter two outlines some selected characteristics of spatial disparities of economic…

  12. Gender, Games and Space

    ERIC Educational Resources Information Center

    de Castell, Suzanne; Larios, Hector; Jenson, Jennifer

    2017-01-01

    We report here a study of spatial learning and action videogame play based on Feng et al.'s (2007) finding that 10 hours spent playing an action videogame significantly improved selective attention and mental rotation. Students with above-average scores on measures of spatial abilities, such as mental rotation, prove more successful in Science,…

  13. A simple enrichment correction factor for improving erosion estimation by rare earth oxide tracers

    USDA-ARS?s Scientific Manuscript database

    Spatially distributed soil erosion data are needed to better understanding soil erosion processes and validating distributed erosion models. Rare earth element (REE) oxides were used to generate spatial erosion data. However, a general concern on the accuracy of the technique arose due to selective ...

  14. Spatial Language and Cognition in Bilingual Minds: Taiwan as a Test Case

    ERIC Educational Resources Information Center

    Lin, Yen-Ting

    2017-01-01

    This dissertation investigates the effect of linguistic and nonlinguistic variables on the use of spatial representations in bilingual speakers of Taiwanese Southern Min (TSM) and Mandarin Chinese (MC) as compared to monolinguals. Linguists and psychologists are particularly interested in the factors that influence the selection among such…

  15. Object-Part Attention Model for Fine-Grained Image Classification

    NASA Astrophysics Data System (ADS)

    Peng, Yuxin; He, Xiangteng; Zhao, Junjie

    2018-03-01

    Fine-grained image classification is to recognize hundreds of subcategories belonging to the same basic-level category, such as 200 subcategories belonging to the bird, which is highly challenging due to large variance in the same subcategory and small variance among different subcategories. Existing methods generally first locate the objects or parts and then discriminate which subcategory the image belongs to. However, they mainly have two limitations: (1) Relying on object or part annotations which are heavily labor consuming. (2) Ignoring the spatial relationships between the object and its parts as well as among these parts, both of which are significantly helpful for finding discriminative parts. Therefore, this paper proposes the object-part attention model (OPAM) for weakly supervised fine-grained image classification, and the main novelties are: (1) Object-part attention model integrates two level attentions: object-level attention localizes objects of images, and part-level attention selects discriminative parts of object. Both are jointly employed to learn multi-view and multi-scale features to enhance their mutual promotions. (2) Object-part spatial constraint model combines two spatial constraints: object spatial constraint ensures selected parts highly representative, and part spatial constraint eliminates redundancy and enhances discrimination of selected parts. Both are jointly employed to exploit the subtle and local differences for distinguishing the subcategories. Importantly, neither object nor part annotations are used in our proposed approach, which avoids the heavy labor consumption of labeling. Comparing with more than 10 state-of-the-art methods on 4 widely-used datasets, our OPAM approach achieves the best performance.

  16. Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment via Increasing Cholinergic Marker Expression.

    PubMed

    Tabrizian, Kaveh; Azami, Kian; Belaran, Maryam; Soodi, Maliheh; Abdi, Khosrou; Fanoudi, Sahar; Sanati, Mehdi; Mottaghi Dastjerdi, Negar; Soltany Rezaee-Rad, Mohammad; Sharifzadeh, Mohammad

    2016-10-01

    Zinc, an essential micronutrient and biochemical element of the human body, plays structural, catalytic, and regulatory roles in numerous physiological functions. In the current study, the effects of a pretraining oral administration of zinc chloride (10, 25, and 50 mg/kg) for 14 consecutive days and post-training bilateral intra-hippocampal infusion of 1400W as a selective inducible nitric oxide synthase (iNOS) inhibitor (10, 50, and 100 μM/side), alone and in combination, on the spatial memory retention in Morris water maze (MWM) were investigated. Animals were trained for 4 days and tested 48 h after completion of training. Also, the molecular effects of these compounds on the expression of choline acetyltransferase (ChAT), as a cholinergic marker in the CA1 region of the hippocampus and medial septal area (MSA), were evaluated. Behavioral and molecular findings of this study showed that a 2-week oral administration of zinc chloride (50 mg/kg) impaired spatial memory retention in MWM and decreased ChAT expression. Immunohistochemical analysis of post-training bilateral intra-hippocampal infusion of 1400W revealed a significant increase in ChAT immunoreactivity. Furthermore, post-training bilateral intra-hippocampal infusion of 1400W into the CA1 region of the hippocampus reversed zinc chloride-induced spatial memory impairment in MWM and significantly increased ChAT expression in comparison with zinc chloride-treated animals. Taken together, these results emphasize the role of selective iNOS inhibitors in reversing zinc chloride-induced spatial memory deficits via modulation of cholinergic marker expression.

  17. Validation of elk resource selection models with spatially independent data

    Treesearch

    Priscilla K. Coe; Bruce K. Johnson; Michael J. Wisdom; John G. Cook; Marty Vavra; Ryan M. Nielson

    2011-01-01

    Knowledge of how landscape features affect wildlife resource use is essential for informed management. Resource selection functions often are used to make and validate predictions about landscape use; however, resource selection functions are rarely validated with data from landscapes independent of those from which the models were built. This problem has severely...

  18. Verbal makes it positive, spatial makes it negative: working memory biases judgments, attention, and moods.

    PubMed

    Storbeck, Justin; Watson, Philip

    2014-12-01

    Prior research has suggested that emotion and working memory domains are integrated, such that positive affect enhances verbal working memory, whereas negative affect enhances spatial working memory (Gray, 2004; Storbeck, 2012). Simon (1967) postulated that one feature of emotion and cognition integration would be reciprocal connectedness (i.e., emotion influences cognition and cognition influences emotion). We explored whether affective judgments and attention to affective qualities are biased by the activation of verbal and spatial working memory mind-sets. For all experiments, participants completed a 2-back verbal or spatial working memory task followed by an endorsement task (Experiments 1 & 2), word-pair selection task (Exp. 3), or attentional dot-probe task (Exp. 4). Participants who had an activated verbal, compared with spatial, working memory mind-set were more likely to endorse pictures (Exp. 1) and words (Exp. 2) as being more positive and to select the more positive word pair out of a set of word pairs that went 'together best' (Exp. 3). Additionally, people who completed the verbal working memory task took longer to disengage from positive stimuli, whereas those who completed the spatial working memory task took longer to disengage from negative stimuli (Exp. 4). Interestingly, across the 4 experiments, we observed higher levels of self-reported negative affect for people who completed the spatial working memory task, which was consistent with their endorsement and attentional bias toward negative stimuli. Therefore, emotion and working memory may have a reciprocal connectedness allowing for bidirectional influence.

  19. Predicting space telerobotic operator training performance from human spatial ability assessment

    NASA Astrophysics Data System (ADS)

    Liu, Andrew M.; Oman, Charles M.; Galvan, Raquel; Natapoff, Alan

    2013-11-01

    Our goal was to determine whether existing tests of spatial ability can predict an astronaut's qualification test performance after robotic training. Because training astronauts to be qualified robotics operators is so long and expensive, NASA is interested in tools that can predict robotics performance before training begins. Currently, the Astronaut Office does not have a validated tool to predict robotics ability as part of its astronaut selection or training process. Commonly used tests of human spatial ability may provide such a tool to predict robotics ability. We tested the spatial ability of 50 active astronauts who had completed at least one robotics training course, then used logistic regression models to analyze the correlation between spatial ability test scores and the astronauts' performance in their evaluation test at the end of the training course. The fit of the logistic function to our data is statistically significant for several spatial tests. However, the prediction performance of the logistic model depends on the criterion threshold assumed. To clarify the critical selection issues, we show how the probability of correct classification vs. misclassification varies as a function of the mental rotation test criterion level. Since the costs of misclassification are low, the logistic models of spatial ability and robotic performance are reliable enough only to be used to customize regular and remedial training. We suggest several changes in tracking performance throughout robotics training that could improve the range and reliability of predictive models.

  20. Spatially distributed modeling of soil organic carbon across China with improved accuracy

    NASA Astrophysics Data System (ADS)

    Li, Qi-quan; Zhang, Hao; Jiang, Xin-ye; Luo, Youlin; Wang, Chang-quan; Yue, Tian-xiang; Li, Bing; Gao, Xue-song

    2017-06-01

    There is a need for more detailed spatial information on soil organic carbon (SOC) for the accurate estimation of SOC stock and earth system models. As it is effective to use environmental factors as auxiliary variables to improve the prediction accuracy of spatially distributed modeling, a combined method (HASM_EF) was developed to predict the spatial pattern of SOC across China using high accuracy surface modeling (HASM), artificial neural network (ANN), and principal component analysis (PCA) to introduce land uses, soil types, climatic factors, topographic attributes, and vegetation cover as predictors. The performance of HASM_EF was compared with ordinary kriging (OK), OK, and HASM combined, respectively, with land uses and soil types (OK_LS and HASM_LS), and regression kriging combined with land uses and soil types (RK_LS). Results showed that HASM_EF obtained the lowest prediction errors and the ratio of performance to deviation (RPD) presented the relative improvements of 89.91%, 63.77%, 55.86%, and 42.14%, respectively, compared to the other four methods. Furthermore, HASM_EF generated more details and more realistic spatial information on SOC. The improved performance of HASM_EF can be attributed to the introduction of more environmental factors, to explicit consideration of the multicollinearity of selected factors and the spatial nonstationarity and nonlinearity of relationships between SOC and selected factors, and to the performance of HASM and ANN. This method may play a useful tool in providing more precise spatial information on soil parameters for global modeling across large areas.

  1. [Sociodemographic context of homicide in Mexico City: a spatial analysis].

    PubMed

    Fuentes Flores, César; Sánchez Salinas, Omar

    2015-12-01

    Investigate the spatial distribution pattern of the homicide rate and its relation to sociodemographic features in the Benito Juárez, Coyoacán, and Cuauhtémoc districts of Mexico City in 2010. Inferential cross-sectional study that uses spatial analysis methods to study the spatial association of the homicide rate and demographic features. Spatial association was determined through the location quotient, multiple regression analysis, and the use of geographically weighted regression. Homicides show a heterogeneous location pattern with high rates in areas with non-residential land use, low population density, and low marginalization. Spatial analysis tools are powerful instruments for the design of prevention- and recreation-focused public safety policies that aim to reduce mortality from external causes such as homicides.

  2. Speckle-field digital holographic microscopy.

    PubMed

    Park, YongKeun; Choi, Wonshik; Yaqoob, Zahid; Dasari, Ramachandra; Badizadegan, Kamran; Feld, Michael S

    2009-07-20

    The use of coherent light in conventional holographic phase microscopy (HPM) poses three major drawbacks: poor spatial resolution, weak depth sectioning, and fixed pattern noise due to unwanted diffraction. Here, we report a technique which can overcome these drawbacks, but maintains the advantage of phase microscopy - high contrast live cell imaging and 3D imaging. A speckle beam of a complex spatial pattern is used for illumination to reduce fixed pattern noise and to improve optical sectioning capability. By recording of the electric field of speckle, we demonstrate high contrast 3D live cell imaging without the need for axial scanning - neither objective lens nor sample stage. This technique has great potential in studying biological samples with improved sensitivity, resolution and optical sectioning capability.

  3. Selecting multiple features delays perception, but only when targets are horizontally arranged.

    PubMed

    Lo, Shih-Yu

    2017-01-01

    Based on the finding that perception is lagged by attention split on multiple features (Lo et al., 2012), this study investigated how the feature-based lag effect interacts with the target spatial arrangement. Participants were presented with gratings the spatial frequencies of which constantly changed. The task was to monitor two gratings of the same or different colors and report their spatial frequencies right before the stimulus offset. The results showed a perceptual lag wherein the reported value was closer to the physical value some time prior to the stimulus offset. This lag effect was larger when the two gratings were of different colors than when they were the same color. Furthermore, the feature-based lag effect was statistically significant when the two gratings were horizontally arranged but not when they were vertically or diagonally arranged. A model is proposed to explain the effect of target arrangement: When targets are horizontally arranged, selecting an additional feature delays perception. When targets are vertically or diagonally arranged, target selection for the lower field is prioritized. This prioritization on the lower target might prompt observers to only select the lower target and ignore the upper one, and this causes more perceptual errors without delaying perception. © 2017 Elsevier B.V. All rights reserved.

  4. Comparing Spatial Distributions of Solar Prominence Mass Derived from Coronal Absorption

    NASA Technical Reports Server (NTRS)

    Gilbert, Holly; Kilper, Gary; Alexander, David; Kucera, Therese

    2010-01-01

    In the present work we extend the use of this mass-inference technique to a sample of prominences observed in at least two coronal lines. This approach, in theory, allows a direct calculation of prominence mass and helium abundance and how these properties vary spatially and temporally. Our motivation is two-fold: to obtain a He(exp 0)/H(exp 0) abundance ratio, and to determine how the relative spatial distribution of the two species varies in prominences. The first of these relies on the theoretical expectation that the amount of absorption at each EUV wavelength is well-characterized. However, in this work we show that due to a saturation of the continuum absorption in the 625 A and 368 A lines (which have much higher opacity compared to 195 A-) the uncertainties in obtaining the relative abundances are too high to give meaningful estimates. This is an important finding because of its impact on future studies in this area. The comparison of the spatial distribution of helium and hydrogen presented here augments previous observational work indicating that cross-field diffusion of neutrals is an important mechanism for mass loss. Significantly different loss timescales for neutral He and H (helium drains much more rapidly than hydrogen) can impact prominence structure, and both the present and past studies suggest this mechanism is playing a role in structure and possibly dynamics. Section 2 of this paper contains a description of the observations and Section 3 summarizes the method used to infer mass along with the criteria imposed in choosing prominences appropriate for this study. Section 3 also contains a discussion of the problems due to limitations of the available data and the implications for determining relative abundances. We present our results in Section 4, including plots of radial-like scans of prominence mass in different lines to show the spatial distribution of the different species. The last section contains a discussion summarizing the importance of the qualitative results found in this work. The Appendix provides a detailed derivation of how to obtain prominence mass and helium abundance (A 1) and includes the data for all prominences studied (A2).

  5. Neutral processes contribute to patterns of spatial variation for flower colour in the Mediterranean Iris lutescens (Iridaceae)

    PubMed Central

    Wang, Hui; Talavera, María; Min, Ya; Flaven, Elodie; Imbert, Eric

    2016-01-01

    Background and Aims Flower colour polymorphism in plants has been used as a classic model for understanding the importance of neutral processes vs. natural selection in population differentiation. However, current explanations for the maintenance of flower colour polymorphism mainly rely on balancing selection, while neutral processes have seldom been championed. Iris lutescens (Iridaceae) is a widespread species in the northern Mediterranean basin, which shows a stable and striking purple–yellow flower colour polymorphism. To evaluate the roles of neutral processes in the spatial variation for flower colour in this species, patterns of neutral genetic variation across its distribution range were quantified, and phenotypic differentiation was compared with neutral genetic differentiation. Methods Genetic diversity levels and population genetic structure were investigated through the genotyping of a collection of 1120 individuals in 41 populations ranging from Spain to France, using a set of eight newly developed microsatellite markers. In addition, phenotypic differentiation for flower colour was also quantified by counting colour morph frequency in each population, and measuring the reflectance spectra of sampled individuals. Key Results Populations in Spain present a sharp colour transition from solely purple to solely yellow. The results provide evidence that genetic drift through limited gene flow is important in the evolution of monomorphic populations. In contrast, most populations in France are polymorphic with both phenotypes, and the colour frequencies vary geographically without any spatial gradients observed. A pattern of isolation by distance is detected in France, and gene flow between adjacent populations seems to be an important factor maintaining populations polymorphic. Conclusions Overall, neutral processes contribute to patterns of spatial variation for flower colour in I. lutescens, but it cannot be excluded that natural selection is also operating. An interaction between neutral processes and natural selection is suggested to explain the spatial variation for flower colour in I. lutescens. PMID:27084922

  6. Neutral processes contribute to patterns of spatial variation for flower colour in the Mediterranean Iris lutescens (Iridaceae).

    PubMed

    Wang, Hui; Talavera, María; Min, Ya; Flaven, Elodie; Imbert, Eric

    2016-05-01

    Flower colour polymorphism in plants has been used as a classic model for understanding the importance of neutral processes vs. natural selection in population differentiation. However, current explanations for the maintenance of flower colour polymorphism mainly rely on balancing selection, while neutral processes have seldom been championed. Iris lutescens (Iridaceae) is a widespread species in the northern Mediterranean basin, which shows a stable and striking purple-yellow flower colour polymorphism. To evaluate the roles of neutral processes in the spatial variation for flower colour in this species, patterns of neutral genetic variation across its distribution range were quantified, and phenotypic differentiation was compared with neutral genetic differentiation. Genetic diversity levels and population genetic structure were investigated through the genotyping of a collection of 1120 individuals in 41 populations ranging from Spain to France, using a set of eight newly developed microsatellite markers. In addition, phenotypic differentiation for flower colour was also quantified by counting colour morph frequency in each population, and measuring the reflectance spectra of sampled individuals. Populations in Spain present a sharp colour transition from solely purple to solely yellow. The results provide evidence that genetic drift through limited gene flow is important in the evolution of monomorphic populations. In contrast, most populations in France are polymorphic with both phenotypes, and the colour frequencies vary geographically without any spatial gradients observed. A pattern of isolation by distance is detected in France, and gene flow between adjacent populations seems to be an important factor maintaining populations polymorphic. Overall, neutral processes contribute to patterns of spatial variation for flower colour in I. lutescens, but it cannot be excluded that natural selection is also operating. An interaction between neutral processes and natural selection is suggested to explain the spatial variation for flower colour in I. lutescens. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. The influence of uncertainty and location-specific conditions on the environmental prioritisation of human pharmaceuticals in Europe.

    PubMed

    Oldenkamp, Rik; Huijbregts, Mark A J; Ragas, Ad M J

    2016-05-01

    The selection of priority APIs (Active Pharmaceutical Ingredients) can benefit from a spatially explicit approach, since an API might exceed the threshold of environmental concern in one location, while staying below that same threshold in another. However, such a spatially explicit approach is relatively data intensive and subject to parameter uncertainty due to limited data. This raises the question to what extent a spatially explicit approach for the environmental prioritisation of APIs remains worthwhile when accounting for uncertainty in parameter settings. We show here that the inclusion of spatially explicit information enables a more efficient environmental prioritisation of APIs in Europe, compared with a non-spatial EU-wide approach, also under uncertain conditions. In a case study with nine antibiotics, uncertainty distributions of the PAF (Potentially Affected Fraction) of aquatic species were calculated in 100∗100km(2) environmental grid cells throughout Europe, and used for the selection of priority APIs. Two APIs have median PAF values that exceed a threshold PAF of 1% in at least one environmental grid cell in Europe, i.e., oxytetracycline and erythromycin. At a tenfold lower threshold PAF (i.e., 0.1%), two additional APIs would be selected, i.e., cefuroxime and ciprofloxacin. However, in 94% of the environmental grid cells in Europe, no APIs exceed either of the thresholds. This illustrates the advantage of following a location-specific approach in the prioritisation of APIs. This added value remains when accounting for uncertainty in parameter settings, i.e., if the 95th percentile of the PAF instead of its median value is compared with the threshold. In 96% of the environmental grid cells, the location-specific approach still enables a reduction of the selection of priority APIs of at least 50%, compared with a EU-wide prioritisation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. DOE Office of Scientific and Technical Information (OSTI.GOV)

    LaGory, K. E.; Walston, L. J.; Goulet, C

    The decline of many snake populations is attributable to habitat loss, and knowledge of habitat use is critical to their conservation. Resource characteristics (e.g., relative availability of different habitat types, soils, and slopes) within a landscape are scale-dependent and may not be equal across multiple spatial scales. Thus, it is important to identify the relevant spatial scales at which resource selection occurs. We conducted a radiotelemetry study of eastern hognose snake (Heterodon platirhinos) home range size and resource use at different hierarchical spatial scales. We present the results for 8 snakes radiotracked during a 2-year study at New Boston Airmore » Force Station (NBAFS) in southern New Hampshire, USA, where the species is listed by the state as endangered. Mean home range size (minimum convex polygon) at NBAFS (51.7 {+-} 14.7 ha) was similar to that reported in other parts of the species range. Radiotracked snakes exhibited different patterns of resource use at different spatial scales. At the landscape scale (selection of locations within the landscape), snakes overutilized old-field and forest edge habitats and underutilized forested habitats and wetlands relative to availability. At this scale, snakes also overutilized areas containing sandy loam soils and areas with lower slope (mean slope = 5.2% at snake locations vs. 6.7% at random locations). We failed to detect some of these patterns of resource use at the home range scale (i.e., within the home range). Our ability to detect resource selection by the snakes only at the landscape scale is likely the result of greater heterogeneity in macrohabitat features at the broader landscape scale. From a management perspective, future studies of habitat selection for rare species should include measurement of available habitat at spatial scales larger than the home range. We suggest that the maintenance of open early successional habitats as a component of forested landscapes will be critical for the persistence of eastern hognose snake populations in the northeastern United States.« less

  9. Explaining geographic gradients in winter selection of landscapes by boreal caribou with implications under global changes in Eastern Canada.

    PubMed

    Beguin, Julien; McIntire, Eliot J B; Fortin, Daniel; Cumming, Steven G; Raulier, Frédéric; Racine, Pierre; Dussault, Claude

    2013-01-01

    Many animal species exhibit broad-scale latitudinal or longitudinal gradients in their response to biotic and abiotic components of their habitat. Although knowing the underlying mechanism of these patterns can be critical to the development of sound measures for the preservation or recovery of endangered species, few studies have yet identified which processes drive the existence of geographical gradients in habitat selection. Using extensive spatial data of broad latitudinal and longitudinal extent, we tested three hypotheses that could explain the presence of geographical gradients in landscape selection of the endangered boreal woodland caribou (Rangifer tarandus caribou) during winter in Eastern Canadian boreal forests: 1) climate-driven selection, which postulates that geographic gradients are surrogates for climatic gradients; 2) road-driven selection, which proposes that boreal caribou adjust their selection for certain habitat classes as a function of proximity to roads; and 3) an additive effect of both roads and climate. Our data strongly supported road-driven selection over climate influences. Thus, direct human alteration of landscapes drives boreal caribou distribution and should likely remain so until the climate changes sufficiently from present conditions. Boreal caribou avoided logged areas two-fold more strongly than burnt areas. Limiting the spread of road networks and accounting for the uneven impact of logging compared to wildfire should therefore be integral parts of any habitat management plan and conservation measures within the range of the endangered boreal caribou. The use of hierarchical spatial models allowed us to explore the distribution of spatially-structured errors in our models, which in turn provided valuable insights for generating alternative hypotheses about processes responsible for boreal caribou distribution.

  10. Emerging feed-forward inhibition allows the robust formation of direction selectivity in the developing ferret visual cortex

    PubMed Central

    Escobar, Gina M.; Maffei, Arianna; Miller, Paul

    2014-01-01

    The computation of direction selectivity requires that a cell respond to joint spatial and temporal characteristics of the stimulus that cannot be separated into independent components. Direction selectivity in ferret visual cortex is not present at the time of eye opening but instead develops in the days and weeks following eye opening in a process that requires visual experience with moving stimuli. Classic Hebbian or spike timing-dependent modification of excitatory feed-forward synaptic inputs is unable to produce direction-selective cells from unselective or weakly directionally biased initial conditions because inputs eventually grow so strong that they can independently drive cortical neurons, violating the joint spatial-temporal activation requirement. Furthermore, without some form of synaptic competition, cells cannot develop direction selectivity in response to training with bidirectional stimulation, as cells in ferret visual cortex do. We show that imposing a maximum lateral geniculate nucleus (LGN)-to-cortex synaptic weight allows neurons to develop direction-selective responses that maintain the requirement for joint spatial and temporal activation. We demonstrate that a novel form of inhibitory plasticity, postsynaptic activity-dependent long-term potentiation of inhibition (POSD-LTPi), which operates in the developing cortex at the time of eye opening, can provide synaptic competition and enables robust development of direction-selective receptive fields with unidirectional or bidirectional stimulation. We propose a general model of the development of spatiotemporal receptive fields that consists of two phases: an experience-independent establishment of initial biases, followed by an experience-dependent amplification or modification of these biases via correlation-based plasticity of excitatory inputs that compete against gradually increasing feed-forward inhibition. PMID:24598528

  11. Moving attention - Evidence for time-invariant shifts of visual selective attention

    NASA Technical Reports Server (NTRS)

    Remington, R.; Pierce, L.

    1984-01-01

    Two experiments measured the time to shift spatial selective attention across the visual field to targets 2 or 10 deg from central fixation. A central arrow cued the most likely target location. The direction of attention was inferred from reaction times to expected, unexpected, and neutral locations. The development of a spatial attentional set with time was examined by presenting target probes at varying times after the cue. There were no effects of distance on the time course of the attentional set. Reaction times for far locations were slower than for near, but the effects of attention were evident by 150 msec in both cases. Spatial attention does not shift with a characteristic, fixed velocity. Rather, velocity is proportional to distance, resulting in a movement time that is invariant over the distances tested.

  12. Emotional modulation of cognitive control: approach-withdrawal states double-dissociate spatial from verbal two-back task performance.

    PubMed

    Gray, J R

    2001-09-01

    Emotional states might selectively modulate components of cognitive control. To test this hypothesis, the author randomly assigned 152 undergraduates (equal numbers of men and women) to watch short videos intended to induce emotional states (approach, neutral, or withdrawal). Each video was followed by a computerized 2-back working memory task (spatial or verbal, equated for difficulty and appearance). Spatial 2-back performance was enhanced by a withdrawal state and impaired by an approach state; the opposite pattern held for verbal performance. The double dissociation held more strongly for participants who made more errors than average across conditions. The results suggest that approach-withdrawal states can have selective influences on components of cognitive control, possibly on a hemispheric basis. They support and extend several frameworks for conceptualizing emotion-cognition interactions.

  13. [Temporal and spatial heterogeneity analysis of optimal value of sensitive parameters in ecological process model: The BIOME-BGC model as an example.

    PubMed

    Li, Yi Zhe; Zhang, Ting Long; Liu, Qiu Yu; Li, Ying

    2018-01-01

    The ecological process models are powerful tools for studying terrestrial ecosystem water and carbon cycle at present. However, there are many parameters for these models, and weather the reasonable values of these parameters were taken, have important impact on the models simulation results. In the past, the sensitivity and the optimization of model parameters were analyzed and discussed in many researches. But the temporal and spatial heterogeneity of the optimal parameters is less concerned. In this paper, the BIOME-BGC model was used as an example. In the evergreen broad-leaved forest, deciduous broad-leaved forest and C3 grassland, the sensitive parameters of the model were selected by constructing the sensitivity judgment index with two experimental sites selected under each vegetation type. The objective function was constructed by using the simulated annealing algorithm combined with the flux data to obtain the monthly optimal values of the sensitive parameters at each site. Then we constructed the temporal heterogeneity judgment index, the spatial heterogeneity judgment index and the temporal and spatial heterogeneity judgment index to quantitatively analyze the temporal and spatial heterogeneity of the optimal values of the model sensitive parameters. The results showed that the sensitivity of BIOME-BGC model parameters was different under different vegetation types, but the selected sensitive parameters were mostly consistent. The optimal values of the sensitive parameters of BIOME-BGC model mostly presented time-space heterogeneity to different degrees which varied with vegetation types. The sensitive parameters related to vegetation physiology and ecology had relatively little temporal and spatial heterogeneity while those related to environment and phenology had generally larger temporal and spatial heterogeneity. In addition, the temporal heterogeneity of the optimal values of the model sensitive parameters showed a significant linear correlation with the spatial heterogeneity under the three vegetation types. According to the temporal and spatial heterogeneity of the optimal values, the parameters of the BIOME-BGC model could be classified in order to adopt different parameter strategies in practical application. The conclusion could help to deeply understand the parameters and the optimal values of the ecological process models, and provide a way or reference for obtaining the reasonable values of parameters in models application.

  14. High-resolution imaging of expertise reveals reliable object selectivity in the fusiform face area related to perceptual performance

    PubMed Central

    McGugin, Rankin Williams; Gatenby, J. Christopher; Gore, John C.; Gauthier, Isabel

    2012-01-01

    The fusiform face area (FFA) is a region of human cortex that responds selectively to faces, but whether it supports a more general function relevant for perceptual expertise is debated. Although both faces and objects of expertise engage many brain areas, the FFA remains the focus of the strongest modular claims and the clearest predictions about expertise. Functional MRI studies at standard-resolution (SR-fMRI) have found responses in the FFA for nonface objects of expertise, but high-resolution fMRI (HR-fMRI) in the FFA [Grill-Spector K, et al. (2006) Nat Neurosci 9:1177–1185] and neurophysiology in face patches in the monkey brain [Tsao DY, et al. (2006) Science 311:670–674] reveal no reliable selectivity for objects. It is thus possible that FFA responses to objects with SR-fMRI are a result of spatial blurring of responses from nonface-selective areas, potentially driven by attention to objects of expertise. Using HR-fMRI in two experiments, we provide evidence of reliable responses to cars in the FFA that correlate with behavioral car expertise. Effects of expertise in the FFA for nonface objects cannot be attributed to spatial blurring beyond the scale at which modular claims have been made, and within the lateral fusiform gyrus, they are restricted to a small area (200 mm2 on the right and 50 mm2 on the left) centered on the peak of face selectivity. Experience with a category may be sufficient to explain the spatially clustered face selectivity observed in this region. PMID:23027970

  15. High-resolution imaging of expertise reveals reliable object selectivity in the fusiform face area related to perceptual performance.

    PubMed

    McGugin, Rankin Williams; Gatenby, J Christopher; Gore, John C; Gauthier, Isabel

    2012-10-16

    The fusiform face area (FFA) is a region of human cortex that responds selectively to faces, but whether it supports a more general function relevant for perceptual expertise is debated. Although both faces and objects of expertise engage many brain areas, the FFA remains the focus of the strongest modular claims and the clearest predictions about expertise. Functional MRI studies at standard-resolution (SR-fMRI) have found responses in the FFA for nonface objects of expertise, but high-resolution fMRI (HR-fMRI) in the FFA [Grill-Spector K, et al. (2006) Nat Neurosci 9:1177-1185] and neurophysiology in face patches in the monkey brain [Tsao DY, et al. (2006) Science 311:670-674] reveal no reliable selectivity for objects. It is thus possible that FFA responses to objects with SR-fMRI are a result of spatial blurring of responses from nonface-selective areas, potentially driven by attention to objects of expertise. Using HR-fMRI in two experiments, we provide evidence of reliable responses to cars in the FFA that correlate with behavioral car expertise. Effects of expertise in the FFA for nonface objects cannot be attributed to spatial blurring beyond the scale at which modular claims have been made, and within the lateral fusiform gyrus, they are restricted to a small area (200 mm(2) on the right and 50 mm(2) on the left) centered on the peak of face selectivity. Experience with a category may be sufficient to explain the spatially clustered face selectivity observed in this region.

  16. Spatial transformation abilities and their relation to later mathematics performance.

    PubMed

    Frick, Andrea

    2018-04-10

    Using a longitudinal approach, this study investigated the relational structure of different spatial transformation skills at kindergarten age, and how these spatial skills relate to children's later mathematics performance. Children were tested at three time points, in kindergarten, first grade, and second grade (N = 119). Exploratory factor analyses revealed two subcomponents of spatial transformation skills: one representing egocentric transformations (mental rotation and spatial scaling), and one representing allocentric transformations (e.g., cross-sectioning, perspective taking). Structural equation modeling suggested that egocentric transformation skills showed their strongest relation to the part of the mathematics test tapping arithmetic operations, whereas allocentric transformations were strongly related to Numeric-Logical and Spatial Functions as well as geometry. The present findings point to a tight connection between early mental transformation skills, particularly the ones requiring a high level of spatial flexibility and a strong sense for spatial magnitudes, and children's mathematics performance at the beginning of their school career.

  17. Variability of pesticide exposure in a stream mesocosm system: macrophyte-dominated vs. non-vegetated sections.

    PubMed

    Beketov, Mikhail A; Liess, Matthias

    2008-12-01

    For flowing water bodies no information is available about patterns of contaminant distribution in flowing water compared to macrophyte-dominated structures. The aim of the study was to examine temporal dynamic and spatial cross-channel variability of pulse exposure of the insecticide thiacloprid in outdoor stream mesocosms. Two distinct cross-channel sections have been considered: macrophyte-dominated littoral and non-vegetated midstream. Median disappearance time ranged from 17 to 43 h (water phase, midstream). We showed that during the exposure pulse (10h) thiacloprid concentrations in the macrophyte-dominated section were 20-60% lower than those in the non-vegetated section. This suggests that spatial variability in contaminant concentrations, particularly in streams containing macrophytes, should be taken into account to enable a more realistic assessment of (i) exposure and associated effects and (ii) mass transport of pesticides and other chemicals into river systems (e.g. losses with surface runoff).

  18. A method for spatial regularisation of a bunch of filaments in a femtosecond laser pulse

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kandidov, V P; Kosareva, O G; Nyakk, A V

    A method for spatial regularisation of chaotically located filaments, which appear in a high-power femtosecond laser pulse, is proposed, numerically substantiated, and experimentally tested. This method is based on the introduction of regular light-field perturbations into the femtosecond-pulse cross section. (letters)

  19. Deconstructing continuous flash suppression

    PubMed Central

    Yang, Eunice; Blake, Randolph

    2012-01-01

    In this paper, we asked to what extent the depth of interocular suppression engendered by continuous flash suppression (CFS) varies depending on spatiotemporal properties of the suppressed stimulus and CFS suppressor. An answer to this question could have implications for interpreting the results in which CFS influences the processing of different categories of stimuli to different extents. In a series of experiments, we measured the selectivity and depth of suppression (i.e., elevation in contrast detection thresholds) as a function of the visual features of the stimulus being suppressed and the stimulus evoking suppression, namely, the popular “Mondrian” CFS stimulus (N. Tsuchiya & C. Koch, 2005). First, we found that CFS differentially suppresses the spatial components of the suppressed stimulus: Observers' sensitivity for stimuli of relatively low spatial frequency or cardinally oriented features was more strongly impaired in comparison to high spatial frequency or obliquely oriented stimuli. Second, we discovered that this feature-selective bias primarily arises from the spatiotemporal structure of the CFS stimulus, particularly within information residing in the low spatial frequency range and within the smooth rather than abrupt luminance changes over time. These results imply that this CFS stimulus operates by selectively attenuating certain classes of low-level signals while leaving others to be potentially encoded during suppression. These findings underscore the importance of considering the contribution of low-level features in stimulus-driven effects that are reported under CFS. PMID:22408039

  20. Deconstructing continuous flash suppression.

    PubMed

    Yang, Eunice; Blake, Randolph

    2012-03-08

    In this paper, we asked to what extent the depth of interocular suppression engendered by continuous flash suppression (CFS) varies depending on spatiotemporal properties of the suppressed stimulus and CFS suppressor. An answer to this question could have implications for interpreting the results in which CFS influences the processing of different categories of stimuli to different extents. In a series of experiments, we measured the selectivity and depth of suppression (i.e., elevation in contrast detection thresholds) as a function of the visual features of the stimulus being suppressed and the stimulus evoking suppression, namely, the popular "Mondrian" CFS stimulus (N. Tsuchiya & C. Koch, 2005). First, we found that CFS differentially suppresses the spatial components of the suppressed stimulus: Observers' sensitivity for stimuli of relatively low spatial frequency or cardinally oriented features was more strongly impaired in comparison to high spatial frequency or obliquely oriented stimuli. Second, we discovered that this feature-selective bias primarily arises from the spatiotemporal structure of the CFS stimulus, particularly within information residing in the low spatial frequency range and within the smooth rather than abrupt luminance changes over time. These results imply that this CFS stimulus operates by selectively attenuating certain classes of low-level signals while leaving others to be potentially encoded during suppression. These findings underscore the importance of considering the contribution of low-level features in stimulus-driven effects that are reported under CFS.

  1. Attentional selection of relative SF mediates global versus local processing: evidence from EEG.

    PubMed

    Flevaris, Anastasia V; Bentin, Shlomo; Robertson, Lynn C

    2011-06-13

    Previous research on functional hemispheric differences in visual processing has associated global perception with low spatial frequency (LSF) processing biases of the right hemisphere (RH) and local perception with high spatial frequency (HSF) processing biases of the left hemisphere (LH). The Double Filtering by Frequency (DFF) theory expanded this hypothesis by proposing that visual attention selects and is directed to relatively LSFs by the RH and relatively HSFs by the LH, suggesting a direct causal relationship between SF selection and global versus local perception. We tested this idea in the current experiment by comparing activity in the EEG recorded at posterior right and posterior left hemisphere sites while participants' attention was directed to global or local levels of processing after selection of relatively LSFs versus HSFs in a previous stimulus. Hemispheric asymmetry in the alpha band (8-12 Hz) during preparation for global versus local processing was modulated by the selected SF. In contrast, preparatory activity associated with selection of SF was not modulated by the previously attended level (global/local). These results support the DFF theory that top-down attentional selection of SF mediates global and local processing.

  2. Auditory Spatial Attention Representations in the Human Cerebral Cortex

    PubMed Central

    Kong, Lingqiang; Michalka, Samantha W.; Rosen, Maya L.; Sheremata, Summer L.; Swisher, Jascha D.; Shinn-Cunningham, Barbara G.; Somers, David C.

    2014-01-01

    Auditory spatial attention serves important functions in auditory source separation and selection. Although auditory spatial attention mechanisms have been generally investigated, the neural substrates encoding spatial information acted on by attention have not been identified in the human neocortex. We performed functional magnetic resonance imaging experiments to identify cortical regions that support auditory spatial attention and to test 2 hypotheses regarding the coding of auditory spatial attention: 1) auditory spatial attention might recruit the visuospatial maps of the intraparietal sulcus (IPS) to create multimodal spatial attention maps; 2) auditory spatial information might be encoded without explicit cortical maps. We mapped visuotopic IPS regions in individual subjects and measured auditory spatial attention effects within these regions of interest. Contrary to the multimodal map hypothesis, we observed that auditory spatial attentional modulations spared the visuotopic maps of IPS; the parietal regions activated by auditory attention lacked map structure. However, multivoxel pattern analysis revealed that the superior temporal gyrus and the supramarginal gyrus contained significant information about the direction of spatial attention. These findings support the hypothesis that auditory spatial information is coded without a cortical map representation. Our findings suggest that audiospatial and visuospatial attention utilize distinctly different spatial coding schemes. PMID:23180753

  3. An Atlas of Illinois State University Affairs.

    ERIC Educational Resources Information Center

    Sublett, Michael D., Ed.; And Others

    Twelve reports on the spatial patterns present on the campus of Illinois State University are divided into three sections. Following an introduction, the first section focuses on behavioral patterns such as seating choices made in the university cafeteria or the classroom. Section II deals with the measures people take to save time. A microstudy…

  4. Estimating and mapping ecological processes influencing microbial community assembly

    DOE PAGES

    Stegen, James C.; Lin, Xueju; Fredrickson, Jim K.; ...

    2015-05-01

    Ecological community assembly is governed by a combination of (i) selection resulting from among-taxa differences in performance; (ii) dispersal resulting from organismal movement; and (iii) ecological drift resulting from stochastic changes in population sizes. The relative importance and nature of these processes can vary across environments. Selection can be homogeneous or variable, and while dispersal is a rate, we conceptualize extreme dispersal rates as two categories; dispersal limitation results from limited exchange of organisms among communities, and homogenizing dispersal results from high levels of organism exchange. To estimate the influence and spatial variation of each process we extend a recentlymore » developed statistical framework, use a simulation model to evaluate the accuracy of the extended framework, and use the framework to examine subsurface microbial communities over two geologic formations. For each subsurface community we estimate the degree to which it is influenced by homogeneous selection, variable selection, dispersal limitation, and homogenizing dispersal. Our analyses revealed that the relative influences of these ecological processes vary substantially across communities even within a geologic formation. We further identify environmental and spatial features associated with each ecological process, which allowed mapping of spatial variation in ecological-process-influences. The resulting maps provide a new lens through which ecological systems can be understood; in the subsurface system investigated here they revealed that the influence of variable selection was associated with the rate at which redox conditions change with subsurface depth.« less

  5. A Wearable Channel Selection-Based Brain-Computer Interface for Motor Imagery Detection.

    PubMed

    Lo, Chi-Chun; Chien, Tsung-Yi; Chen, Yu-Chun; Tsai, Shang-Ho; Fang, Wai-Chi; Lin, Bor-Shyh

    2016-02-06

    Motor imagery-based brain-computer interface (BCI) is a communication interface between an external machine and the brain. Many kinds of spatial filters are used in BCIs to enhance the electroencephalography (EEG) features related to motor imagery. The approach of channel selection, developed to reserve meaningful EEG channels, is also an important technique for the development of BCIs. However, current BCI systems require a conventional EEG machine and EEG electrodes with conductive gel to acquire multi-channel EEG signals and then transmit these EEG signals to the back-end computer to perform the approach of channel selection. This reduces the convenience of use in daily life and increases the limitations of BCI applications. In order to improve the above issues, a novel wearable channel selection-based brain-computer interface is proposed. Here, retractable comb-shaped active dry electrodes are designed to measure the EEG signals on a hairy site, without conductive gel. By the design of analog CAR spatial filters and the firmware of EEG acquisition module, the function of spatial filters could be performed without any calculation, and channel selection could be performed in the front-end device to improve the practicability of detecting motor imagery in the wearable EEG device directly or in commercial mobile phones or tablets, which may have relatively low system specifications. Finally, the performance of the proposed BCI is investigated, and the experimental results show that the proposed system is a good wearable BCI system prototype.

  6. Selecting a spatial resolution for estimation of per-field green leaf area index

    NASA Technical Reports Server (NTRS)

    Curran, Paul J.; Williamson, H. Dawn

    1988-01-01

    For any application of multispectral scanner (MSS) data, a user is faced with a number of choices concerning the characteristics of the data; one of these is their spatial resolution. A pilot study was undertaken to determine the spatial resolution that would be optimal for the per-field estimation of green leaf area index (GLAI) in grassland. By reference to empirically-derived data from three areas of grassland, the suitable spatial resolution was hypothesized to lie in the lower portion of a 2-18 m range. To estimate per-field GLAI, airborne MSS data were collected at spatial resolutions of 2 m, 5 m and 10 m. The highest accuracies of per-field GLAI estimation were achieved using MSS data with spatial resolutions of 2 m and 5 m.

  7. Support for distinct subcomponents of spatial working memory: a double dissociation between spatial-simultaneous and spatial-sequential performance in unilateral neglect.

    PubMed

    Wansard, Murielle; Bartolomeo, Paolo; Bastin, Christine; Segovia, Fermín; Gillet, Sophie; Duret, Christophe; Meulemans, Thierry

    2015-01-01

    Over the last decade, many studies have demonstrated that visuospatial working memory (VSWM) can be divided into separate subsystems dedicated to the retention of visual patterns and their serial order. Impaired VSWM has been suggested to exacerbate left visual neglect in right-brain-damaged individuals. The aim of this study was to investigate the segregation between spatial-sequential and spatial-simultaneous working memory in individuals with neglect. We demonstrated that patterns of results on these VSWM tasks can be dissociated. Spatial-simultaneous and sequential aspects of VSWM can be selectively impaired in unilateral neglect. Our results support the hypothesis of multiple VSWM subsystems, which should be taken into account to better understand neglect-related deficits.

  8. Implications of high-spatial-resolution thermal infrared (Termoskan) data for Mars landing site selection

    NASA Technical Reports Server (NTRS)

    Betts, Bruce H.

    1994-01-01

    Thermal infrared observations of Mars from spacecraft provide physical information about the upper thermal skin depth of the surface, which is on the order of a few centimeters in depth and thus very significant for lander site selection. The Termoskan instrument onboard the Soviet Phobos '88 spacecraft acquired the highest spatial-resolution thermal infrared data obtained for Mars, ranging in resolution from 300 m to 3 km per pixel. It simultaneously obtained broadband reflected solar flux data. Although the 6 deg N - 30 deg S Termoskan coverage only slightly overlaps the nominal Mars Pathfinder target range, the implications of Termoskan data for that overlap region and the extrapolations that can be made to other regions give important clues for optimal landing site selection.

  9. The relationship between 3D morphology of optic disc and spatial patterns of visual field loss in glaucoma

    NASA Astrophysics Data System (ADS)

    Wang, Mengyu; Wang, Hui; Baniasadi, Neda; Elze, Tobias

    2017-02-01

    Purpose: Optic disc tilt defined over 3D optic disc morphology has been shown to be associated with the location of initial glaucomatous damages. In this work, we study the impact of optic cup depth (OCD) on spatial patterns of visual field loss in glaucoma. Methods: Pairs of reliable Cirrus OCT scans around optic disc and Humphrey visual fields of glaucoma patients without visually significant cataract and age-related macular degeneration were selected. The most recent visit of a randomly selected eye of each patient was chosen. The OCD was automatically calculated on the superior-inferior cross sectional image passing through the optic disc center. The correlations between the mean pattern deviation (PD) of each sector in glaucoma hemifield test (GHT) and Garway-Heath scheme and OCD were evaluated for all severities glaucoma and mild glaucoma (mean deviation >= -5 dB), respectively. Results: 424 eyes of 424 patients passed the data reliability criteria with 346 mild glaucoma patients. For all severities glaucoma, there was no significant correlation between the mean sector PD and OCD. For mild glaucoma, OCD was uniquely correlated to the mean PD of the inferior pericentral sector (r=-0.18, p=0.01) in GHT, which was independent of mean deviation and retinal nerve fiber layer thickness (p<0.001 for both). Conclusion: OCD was uniquely correlated to the vision loss of the inferior pericentral sector in GHT and Garway- Health scheme for mild glaucoma. Future advancement of OCT imaging techniques may provide better clinical diagnosis for early glaucoma by focusing on 3D morphological variation of the optic disc.

  10. Grid and non-grid cells in medial entorhinal cortex represent spatial location and environmental features with complementary coding schemes

    PubMed Central

    Diehl, Geoffrey W.; Hon, Olivia J.; Leutgeb, Stefan; Leutgeb, Jill K.

    2017-01-01

    Summary The medial entorhinal cortex (mEC) has been identified as a hub for spatial information processing by the discovery of grid, border, and head-direction cells. Here we find that in addition to these well characterized classes, nearly all of the remaining two thirds of mEC cells can be categorized as spatially selective. We refer to these cells as non-grid spatial cells and confirmed that their spatial firing patterns were unrelated to running speed and highly reproducible within the same environment. However, in response to manipulations of environmental features, such as box shape or box color, non-grid spatial cells completely reorganized their spatial firing patterns. At the same time, grid cells retained their spatial alignment and predominantly responded with redistributed firing rates across their grid fields. Thus, mEC contains a joint representation of both spatial and environmental feature content, with specialized cell types showing different types of integrated coding of multimodal information. PMID:28343867

  11. The spatial impact of neighbouring on the exports activities of COMESA countries by using spatial panel models

    NASA Astrophysics Data System (ADS)

    Hamzalouh, L.; Ismail, M. T.; Rahman, R. A.

    2017-09-01

    In this paper, spatial panel models were used and the method for selecting the best model amongst the spatial fixed effects model and the spatial random effects model to estimate the fitting model by using the robust Hausman test for analysis of the exports pattern of the Common Market for Eastern and Southern African (COMESA) countries. And examine the effects of the interactions of the economic statistic of explanatory variables on the exports of the COMESA. Results indicated that the spatial Durbin model with fixed effects specification should be tested and considered in most cases of this study. After that, the direct and indirect effects among COMESA regions were assessed, and the role of indirect spatial effects in estimating exports was empirically demonstrated. Regarding originality and research value, and to the best of the authors’ knowledge, this is the first attempt to examine exports between COMESA and its member countries through spatial panel models using XSMLE, which is a new command for spatial analysis using STATA.

  12. Using neuronal populations to study the mechanisms underlying spatial and feature attention

    PubMed Central

    Cohen, Marlene R.; Maunsell, John H.R.

    2012-01-01

    Summary Visual attention affects both perception and neuronal responses. Whether the same neuronal mechanisms mediate spatial attention, which improves perception of attended locations, and non-spatial forms of attention has been a subject of considerable debate. Spatial and feature attention have similar effects on individual neurons. Because visual cortex is retinotopically organized, however, spatial attention can co-modulate local neuronal populations, while feature attention generally requires more selective modulation. We compared the effects of feature and spatial attention on local and spatially separated populations by recording simultaneously from dozens of neurons in both hemispheres of V4. Feature and spatial attention affect the activity of local populations similarly, modulating both firing rates and correlations between pairs of nearby neurons. However, while spatial attention appears to act on local populations, feature attention is coordinated across hemispheres. Our results are consistent with a unified attentional mechanism that can modulate the responses of arbitrary subgroups of neurons. PMID:21689604

  13. Spatial Analysis of China Province-level Perinatal Mortality

    PubMed Central

    XIANG, Kun; SONG, Deyong

    2016-01-01

    Background: Using spatial analysis tools to determine the spatial patterns of China province-level perinatal mortality and using spatial econometric model to examine the impacts of health care resources and different socio-economic factors on perinatal mortality. Methods: The Global Moran’s I index is used to examine whether the spatial autocorrelation exists in selected regions and Moran’s I scatter plot to examine the spatial clustering among regions. Spatial econometric models are used to investigate the spatial relationships between perinatal mortality and contributing factors. Results: The overall Moran’s I index indicates that perinatal mortality displays positive spatial autocorrelation. Moran’s I scatter plot analysis implies that there is a significant clustering of mortality in both high-rate regions and low-rate regions. The spatial econometric models analyses confirm the existence of a direct link between perinatal mortality and health care resources, socio-economic factors. Conclusions: Since a positive spatial autocorrelation has been detected in China province-level perinatal mortality, the upgrading of regional economic development and medical service level will affect the mortality not only in region itself but also its adjacent regions. PMID:27398334

  14. The effects of selective and divided attention on sensory precision and integration.

    PubMed

    Odegaard, Brian; Wozny, David R; Shams, Ladan

    2016-02-12

    In our daily lives, our capacity to selectively attend to stimuli within or across sensory modalities enables enhanced perception of the surrounding world. While previous research on selective attention has studied this phenomenon extensively, two important questions still remain unanswered: (1) how selective attention to a single modality impacts sensory integration processes, and (2) the mechanism by which selective attention improves perception. We explored how selective attention impacts performance in both a spatial task and a temporal numerosity judgment task, and employed a Bayesian Causal Inference model to investigate the computational mechanism(s) impacted by selective attention. We report three findings: (1) in the spatial domain, selective attention improves precision of the visual sensory representations (which were relatively precise), but not the auditory sensory representations (which were fairly noisy); (2) in the temporal domain, selective attention improves the sensory precision in both modalities (both of which were fairly reliable to begin with); (3) in both tasks, selective attention did not exert a significant influence over the tendency to integrate sensory stimuli. Therefore, it may be postulated that a sensory modality must possess a certain inherent degree of encoding precision in order to benefit from selective attention. It also appears that in certain basic perceptual tasks, the tendency to integrate crossmodal signals does not depend significantly on selective attention. We conclude with a discussion of how these results relate to recent theoretical considerations of selective attention. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  15. Unique Fock quantization of scalar cosmological perturbations

    NASA Astrophysics Data System (ADS)

    Fernández-Méndez, Mikel; Mena Marugán, Guillermo A.; Olmedo, Javier; Velhinho, José M.

    2012-05-01

    We investigate the ambiguities in the Fock quantization of the scalar perturbations of a Friedmann-Lemaître-Robertson-Walker model with a massive scalar field as matter content. We consider the case of compact spatial sections (thus avoiding infrared divergences), with the topology of a three-sphere. After expanding the perturbations in series of eigenfunctions of the Laplace-Beltrami operator, the Hamiltonian of the system is written up to quadratic order in them. We fix the gauge of the local degrees of freedom in two different ways, reaching in both cases the same qualitative results. A canonical transformation, which includes the scaling of the matter-field perturbations by the scale factor of the geometry, is performed in order to arrive at a convenient formulation of the system. We then study the quantization of these perturbations in the classical background determined by the homogeneous variables. Based on previous work, we introduce a Fock representation for the perturbations in which: (a) the complex structure is invariant under the isometries of the spatial sections and (b) the field dynamics is implemented as a unitary operator. These two properties select not only a unique unitary equivalence class of representations, but also a preferred field description, picking up a canonical pair of field variables among all those that can be obtained by means of a time-dependent scaling of the matter field (completed into a linear canonical transformation). Finally, we present an equivalent quantization constructed in terms of gauge-invariant quantities. We prove that this quantization can be attained by a mode-by-mode time-dependent linear canonical transformation which admits a unitary implementation, so that it is also uniquely determined.

  16. Scaffold of Asymmetric Organic Compounds - Magnetite Plaquettes

    NASA Technical Reports Server (NTRS)

    Chan, Q. H. S.; Zolensky, M. E.; Martinez, J.

    2015-01-01

    Life on Earth shows preference towards the set of organics with particular spatial configurations, this 'selectivity' is a crucial criterion for life. With only rare exceptions, life prefers the left- (L-) form over the right- (D-) form of amino acids, resulting in an L-enantiomeric excess (L-ee). Recent studies have shown Lee for alpha-methyl amino acids in some chondrites. Since these amino acids have limited terrestrial occurrence, the origin of their stereoselectivity is nonbiological, and it seems appropriate to conclude that chiral asymmetry, the molecular characteristic that is common to all terrestrial life form, has an abiotic origin. A possible abiotic mechanism that can produce chiral asymmetry in meteoritic amino acids is their formation with the presence of asymmetric catalysts, as mineral crystallization can produce spatially asymmetric structures. Magnetite is shown to be an effective catalyst for the formation of amino acids that are commonly found in chondrites. Magnetite 'plaquettes' (or 'platelets'), first described by Jedwab, show an interesting morphology of barrel-shaped stacks of magnetite disks with an apparent dislocation-induced spiral growth that seem to be connected at the center. A recent study by Singh et al. has shown that magnetites can self-assemble into helical superstructures. Such molecular asymmetry could be inherited by adsorbed organic molecules. In order to understand the distribution of 'spiral' magnetites in different meteorite classes, as well as to investigate their apparent spiral configurations and possible correlation to molecular asymmetry, we observed polished sections of carbonaceous chondrites (CC) using scanning electron microscope (SEM) imaging. The sections were also studied by electron backscattered diffraction (EBSD) in order to reconstruct the crystal orientation along the stack of magnetite disks.

  17. High-Resolution Ambient MS Imaging of Negative Ions in Positive Ion Mode: Using Dicationic Reagents with the Single-Probe

    NASA Astrophysics Data System (ADS)

    Rao, Wei; Pan, Ning; Tian, Xiang; Yang, Zhibo

    2016-01-01

    We have used the Single-probe, a miniaturized sampling device utilizing in-situ surface microextraction for ambient mass spectrometry (MS) analysis, for the high resolution MS imaging (MSI) of negatively charged species in the positive ionization mode. Two dicationic compounds, 1,5-pentanediyl-bis(1-butylpyrrolidinium) difluoride [C5(bpyr)2F2] and 1,3-propanediyl-bis(tripropylphosphonium) difluoride [C3(triprp)2F2], were added into the sampling solvent to form 1+ charged adducts with the negatively charged species extracted from tissues. We were able to detect 526 and 322 negatively charged species this way using [C5(bpyr)2F2] and [C3(triprp)2F2], respectively, including oleic acid, arachidonic acid, and several species of phosphatidic acid, phosphoethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and others. In conjunction with the identification of the non-adduct cations, we have tentatively identified a total number of 1200 and 828 metabolites from mouse brain sections using [C5(bpyr)2F2] and [C3(triprp)2F2], respectively, through high mass accuracy measurements (mass error <5 ppm); MS/MS analyses were also performed to verify the identity of selected species. In addition to the high mass accuracy measurement, we were able to generate high spatial resolution (~17 μm) MS images of mouse brain sections. Our study demonstrated that utilization of dicationic compounds in the surface microextraction with the Single-probe device can perform high mass and spatial resolution ambient MSI measurements of broader types of compounds in tissues. Other reagents can be potentially used with the Single-probe device for a variety of reactive MSI studies to enable the analysis of species that are previously intractable.

  18. Practical recipes for the model order reduction, dynamical simulation and compressive sampling of large-scale open quantum systems

    NASA Astrophysics Data System (ADS)

    Sidles, John A.; Garbini, Joseph L.; Harrell, Lee E.; Hero, Alfred O.; Jacky, Jonathan P.; Malcomb, Joseph R.; Norman, Anthony G.; Williamson, Austin M.

    2009-06-01

    Practical recipes are presented for simulating high-temperature and nonequilibrium quantum spin systems that are continuously measured and controlled. The notion of a spin system is broadly conceived, in order to encompass macroscopic test masses as the limiting case of large-j spins. The simulation technique has three stages: first the deliberate introduction of noise into the simulation, then the conversion of that noise into an equivalent continuous measurement and control process, and finally, projection of the trajectory onto state-space manifolds having reduced dimensionality and possessing a Kähler potential of multilinear algebraic form. These state-spaces can be regarded as ruled algebraic varieties upon which a projective quantum model order reduction (MOR) is performed. The Riemannian sectional curvature of ruled Kählerian varieties is analyzed, and proved to be non-positive upon all sections that contain a rule. These manifolds are shown to contain Slater determinants as a special case and their identity with Grassmannian varieties is demonstrated. The resulting simulation formalism is used to construct a positive P-representation for the thermal density matrix. Single-spin detection by magnetic resonance force microscopy (MRFM) is simulated, and the data statistics are shown to be those of a random telegraph signal with additive white noise. Larger-scale spin-dust models are simulated, having no spatial symmetry and no spatial ordering; the high-fidelity projection of numerically computed quantum trajectories onto low dimensionality Kähler state-space manifolds is demonstrated. The reconstruction of quantum trajectories from sparse random projections is demonstrated, the onset of Donoho-Stodden breakdown at the Candès-Tao sparsity limit is observed, a deterministic construction for sampling matrices is given and methods for quantum state optimization by Dantzig selection are given.

  19. Selective Memories: Infants' Encoding Is Enhanced in Selection via Suppression

    ERIC Educational Resources Information Center

    Markant, Julie; Amso, Dima

    2013-01-01

    The present study examined the hypothesis that inhibitory visual selection mechanisms play a vital role in memory by limiting distractor interference during item encoding. In Experiment 1a we used a modified spatial cueing task in which 9-month-old infants encoded multiple category exemplars in the contexts of an attention orienting mechanism…

  20. Spatially resolved proteome mapping of laser capture microdissected tissue with automated sample transfer to nanodroplets.

    PubMed

    Zhu, Ying; Dou, Maowei; Piehowski, Paul D; Liang, Yiran; Wang, Fangjun; Chu, Rosalie K; Chrisler, Will; Smith, Jordan N; Schwarz, Kaitlynn C; Shen, Yufeng; Shukla, Anil K; Moore, Ronald J; Smith, Richard D; Qian, Wei-Jun; Kelly, Ryan T

    2018-06-24

    Current mass spectrometry (MS)-based proteomics approaches are ineffective for mapping protein expression in tissue sections with high spatial resolution due to the limited overall sensitivity of conventional workflows. Here we report an integrated and automated method to advance spatially resolved proteomics by seamlessly coupling laser capture microdissection (LCM) with a recently developed nanoliter-scale sample preparation system termed nanoPOTS (Nanodroplet Processing in One pot for Trace Samples). The workflow is enabled by prepopulating nanowells with DMSO, which serves as a sacrificial capture liquid for microdissected tissues. The DMSO droplets efficiently collect laser-pressure catapulted LCM tissues as small as 20 µm in diameter with success rates >87%. We also demonstrate that tissue treatment with DMSO can significantly improve proteome coverage, likely due to its ability to dissolve lipids from tissue and enhance protein extraction efficiency. The LCM-nanoPOTS platform was able to identify 180, 695, and 1827 protein groups on average from 12-µm-thick rat brain cortex tissue sections with diameters of 50, 100, and 200 µm, respectively. We also analyzed 100-µm-diameter sections corresponding to 10-18 cells from three different regions of rat brain and comparatively quantified ~1000 proteins, demonstrating the potential utility for high-resolution spatially resolved mapping of protein expression in tissues. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

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