Kirkpatrick and Beyond: A Review of Models of Training Evaluation. IES Report.

ERIC Educational Resources Information Center

Tamkin, P.; Yarnall, J.; Kerrin, M.

Many organizations are not satisfied that their methods of evaluating training are rigorous or extensive enough to answer questions of value to them. Complaints about Kirkpatrick's popular four-step model (1959) of training evaluation are that each level is assumed to be associated with the previous and next levels and that the model is too simple…

Assessment of Operational Progress of NASA Langley Developed Windshield and Microphone for Infrasound

DTIC Science & Technology

2013-04-01

Assessment of Operational Progress of NASA Langley Developed Windshield and Microphone for Infrasound by W.C. Kirkpatrick Alberts, II...Windshield and Microphone for Infrasound W.C. Kirkpatrick Alberts, II, Stephen M. Tenney, and John M. Noble Sensors and Electron Devices Directorate...2013 4. TITLE AND SUBTITLE Assessment of Operational Progress of NASA Langley Developed Windshield and Microphone for Infrasound 5a. CONTRACT

Free-Energy Fluctuations and Chaos in the Sherrington-Kirkpatrick Model

NASA Astrophysics Data System (ADS)

Aspelmeier, T.

2008-03-01

The sample-to-sample fluctuations ΔFN of the free-energy in the Sherrington-Kirkpatrick model are shown rigorously to be related to bond chaos. Via this connection, the fluctuations become analytically accessible by replica methods. The replica calculation for bond chaos shows that the exponent μ governing the growth of the fluctuations with system size N, ΔFN˜Nμ, is bounded by μ≤(1)/(4).

Adapting Levels 1 and 2 of Kirkpatrick's Model of Training Evaluation to Examine the Effectiveness of a Tertiary-Level Writing Course

ERIC Educational Resources Information Center

Aryadoust, Vahid

2017-01-01

This study adapts Levels 1 and 2 of Kirkpatrick's model of training evaluation to evaluate learning outcomes of an English as a second language (ESL) paragraph writing course offered by a major Asian university. The study uses a combination of surveys and writing tests administered at the beginning and end of the course. The survey evaluated…

Reticulated Vitreous Carbon Electrodes for Gas Phase Pulsed Corona Reactors.

DTIC Science & Technology

1999-01-01

AFRL-ML-TY-TP-1999-4546 RETICULATED VITREOUS CARBON ELECTRODES FOR GAS PHASE PULSED CORONA REACTORS B.R. LOCKE M. KIRKPATRICK H. HANSON W.C...SUBTITLE Reticulated Vitreous Carbon Electrodes for Gas Phase Pulsed Corona Reactors 6. AUTHOR(S) B.R. Locke, M. Kirkpatrick, H. Hanson, and W.C. Finney...incorporating reticulated vitreous carbon electrodes is demonstrated to be effective for the removal of nitrogen oxides from synthetic air mixtures

Emerging Infectious Threats to the Blood Supply: Seroepidemiological Studies in Iran – a Review

PubMed Central

Karimi, Gharib; Gharehbaghian, Ahmad; Tafti, Mohammad Fallah; Vafaiyan, Vida

2013-01-01

Summary The risk of transfusion-transmitted infections has been greatly reduced by improvements in donor screening and testing. However, newly recognized blood-borne infectious agents can be threats to blood safety. In order to evaluate the prevalence some of these agents in blood donors, a systematic review was conducted. Data were obtained from published papers related to HGV, Torque Teno virus (TTV), HTLV, West Nile virus (WNV) and SEN virus (SEN-V). Based on these studies, the prevalence of HGV varied from 1 to 8.6% for anti-E2 and from 0 to 4.8% for HGV RNA. The prevalence of TTV DNA and HTLV-I varied from 2.7 to 79.5% and from 0.013 to 2.3%, respectively. The WNV-specific IgM antibody and WNV RNA are negative in blood donors. Prevalence rates of SEN-V in Iranian blood donors range from 23 to 90.8%. Consequences of these infectious agents for blood safety are different. Thus, the need to perform laboratory screening as well as effectiveness and efficiency of laboratory tests depend on pathogenicity level and epidemiological conditions of emerging infections. However, being prepared based on the current level of risk and interventions to reduce the risk can be effective in reducing the potential threat for blood supply. PMID:23922546

Moving the Needle: Simulation's Impact on Patient Outcomes.

PubMed

Cox, Tiffany; Seymour, Neal; Stefanidis, Dimitrios

2015-08-01

This review investigates the available literature that addresses the impact simulator training has on patient outcomes. The authors conducted a comprehensive literature search of studies reporting outcomes of simulation training and categorized studies based on the Kirkpatrick model of training evaluation. Kirkpatrick level 4 studies reporting patient outcomes were identified and included in this review. Existing evidence is promising, demonstrating patient benefits as a result of simulation training for central line placement, obstetric emergencies, cataract surgery, laparoscopic inguinal hernia repair, and team training. Copyright © 2015 Elsevier Inc. All rights reserved.

The effectiveness of clinical teaching of mental health courses in nursing using clinical supervision and Kirkpatrick's model.

PubMed

Maddineshat, Maryam; Hashemi, Mitra; Besharati, Reza; Gholami, Sepideh; Ghavidel, Fatemeh

2018-01-01

Clinical experience associated with the fear and anxiety of nursing students in the psychiatric unit. Mental health nursing instructors find it challenging to teach nursing students to deal with patients with mental disorders in an environment where they need to provide patient teaching and clinical decision-making based on evidence and new technology. To measure the effectiveness of clinical teaching of mental health courses in nursing using clinical supervision and Kirkpatrick's model evaluation in the psychiatry unit of Imam Reza Hospital, Bojnurd, Iran. This cross-sectional study was carried out from 2011 to 2016 on 76 nursing students from a university as part of a clinical mental health course in two semesters. The students were selected by a non-probable convenient sampling method. After completing their clinical education, each student responded to checklist questions based on the four-level Kirkpatrick's model evaluation and open questions relating to clinical supervision. Finally, all data was analyzed using the SPSS version 16. The students have evaluated clinical supervision as a useful approach, and appreciated the instructor's supportive behavior during teaching and imparting clinical skills. This has made them feel relaxed at the end of the clinical teaching course. In addition, in the evaluation through Kirkpatrick's model, more than 70% of the students have been satisfied with the method of conducting the teaching and average score of nursing students' attitude toward mental health students: Their mean self-confidence score was 18.33±1.69, and the mean score of their performance in the study was evaluated to be 93.74±5.3 from 100 points. The results of clinical mental health teaching through clinical supervision and Kirkpatrick's model evaluation show that the satisfaction, self-esteem, attitude, and skill of nursing students are excellent, thereby portraying the effectiveness of clinical teaching. But this program still needs to be reformed. To establish long-term goals and obtain knowledge and clinical skills of nursing, it is recommended to develop a curriculum and evaluate it appropriately.

Transfer of learning and patient outcome in simulated crisis resource management: a systematic review.

PubMed

Boet, Sylvain; Bould, M Dylan; Fung, Lillia; Qosa, Haytham; Perrier, Laure; Tavares, Walter; Reeves, Scott; Tricco, Andrea C

2014-06-01

Simulation-based learning is increasingly used by healthcare professionals as a safe method to learn and practice non-technical skills, such as communication and leadership, required for effective crisis resource management (CRM). This systematic review was conducted to gain a better understanding of the impact of simulation-based CRM teaching on transfer of learning to the workplace and subsequent changes in patient outcomes. Studies on CRM, crisis management, crew resource management, teamwork, and simulation published up to September 2012 were searched in MEDLINE(®), EMBASE™, CINAHL, Cochrane Central Register of Controlled Trials, and ERIC. All studies that used simulation-based CRM teaching with outcomes measured at Kirkpatrick Level 3 (transfer of learning to the workplace) or 4 (patient outcome) were included. Studies measuring only learners' reactions or simple learning (Kirkpatrick Level 1 or 2, respectively) were excluded. Two authors independently reviewed all identified titles and abstracts for eligibility. Nine articles were identified as meeting the inclusion criteria. Four studies measured transfer of simulation-based CRM learning into the clinical setting (Kirkpatrick Level 3). In three of these studies, simulation-enhanced CRM training was found significantly more effective than no intervention or didactic teaching. Five studies measured patient outcomes (Kirkpatrick Level 4). Only one of these studies found that simulation-based CRM training made a clearly significant impact on patient mortality. Based on a small number of studies, this systematic review found that CRM skills learned at the simulation centre are transferred to clinical settings, and the acquired CRM skills may translate to improved patient outcomes, including a decrease in mortality.

Immunotoxins recognising a new epitope on the neural cell adhesion molecule have potent cytotoxic effects against small cell lung cancer.

PubMed

Zangemeister-Wittke, U; Collinson, A R; Frösch, B; Waibel, R; Schenker, T; Stahel, R A

1994-01-01

The present study describes a comparison of two potent immunotoxins which utilise an identical targeting component, a monoclonal antibody (SEN7) specific for small cell lung cancer (SCLC), conjugated to two different effector components, blocked ricin (bR) and Pseudomonas exotoxin A (PE). SEN7 recognises a novel epitope on the neural cell adhesion molecule (NCAM) which is highly associated with SCLC. The immunotoxins SEN7-PE and SEN7-bR were selectively and potently active against a number of SCLC cell lines, of both classic and variant morphologies, inhibiting the incorporation of [3H]leucine with IC50 values ranging between 22 pM and 85 pM and between 7 pM and 62 pM for SEN7-PE and SEN7-bR respectively. Intoxication by both immunotoxins proceeded rapidly following short 2 h lag phases; the initial rates of protein synthesis inhibition occurred with t50 values of 6.5 h for SEN7-PE and 5.5 h for SEN7-bR. Monensin drastically enhanced the cytotoxic activity of the weakly active SEN7-ricin A-chain by 2,100-fold and of SEN7-bR by 80-fold but had no effect on SEN7-PE. In limiting dilution assays, four and more than 4.5 logs of clonogenic SW2 tumour cells were selectively eliminated from the cultures during continuous exposure to the immunotoxins SEN7-PE and SEN7-bR respectively, while antigen-negative cells required up to 1,000-fold more drug for a similar cell kill. SW2 cells surviving SEN7-bR treatment in the cultures did not express NCAM and consequently were not selectively killed by SEN7 immunotoxins. SW2 cells surviving continuous exposure to SEN7-PE showed no alteration in NCAM expression but were more resistant to intoxication mediated by PE. These cells were still sensitive to SEN7-bR.

Full-aperture x-ray tests of Kirkpatrick-Baez modules: preliminary results

NASA Astrophysics Data System (ADS)

Pina, L.; Marsikova, V.; Hudec, R.; Inneman, A.; Marsik, J.; Cash, W.; Shipley, A.; Zeiger, B.

2011-05-01

We report on preliminary results of full aperture X-ray optical tests at the X-ray test facility at the University of Colorado (USA) of four test modules of Kirkpatrick-Baez (KB) X-ray optical systems performed in August 2010. Direct experimental comparisons were made between gold-coated optics of two novel substrates: glass foils and silicon wafers. The preliminary results are promising, with full-width half-maxima of full stacks being of order of 30 arcsec in 2D full arrangement. These results justify further efforts to improve KB optics for use in low-cost, high-performance space-borne astronomical imaging instruments for X-ray wavelengths.

Scanning Kirkpatrick-Baez X-ray telescope to maximize effective area and eliminate spurious images - Design

NASA Technical Reports Server (NTRS)

Kast, J. W.

1975-01-01

We consider the design of a Kirkpatrick-Baez grazing-incidence X-ray telescope to be used in a scan of the sky and analyze the distribution of both properly reflected rays and spurious images over the field of view. To obtain maximum effective area over the field of view, it is necessary to increase the spacing between plates for a scanning telescope as compared to a pointing telescope. Spurious images are necessarily present in this type of lens, but they can be eliminated from the field of view by adding properly located baffles or collimators. Results of a computer design are presented.

A lack of vision: evidence for poor communication of visual problems and support needs in education statements/plans for children with SEN.

PubMed

Little, J-A; Saunders, K J

2015-02-01

Visual dysfunction is more common in children with neurological impairments and previous studies have recommended such children receive visual and refractive assessment. In the UK, children with neurological impairment often have educational statementing for Special Educational Needs (SEN) and the statement should detail all health care and support needs to ensure the child's needs are met during school life. This study examined the representation of visual information in statements of SEN and compared this to orthoptic visual information from school visual assessments for children in a special school in Northern Ireland, UK. The parents of 115 school children in a special school were informed about the study via written information. Participation involved parents permitting the researchers to access their child's SEN educational statement and orthoptic clinical records. Statement information was accessed for 28 participants aged between four and 19 years; 25 contained visual information. Two participants were identified in their statements as having a certification of visual impairment. An additional 10 children had visual acuity ≥ 0.3 logMAR. This visual deficit was not reported in statements in eight out of these 12 cases (67%). 11 participants had significant refractive error and wore spectacles, but only five (45%) had this requirement recorded in their statement. Overall, 10 participants (55%) had either reduced visual acuity or significant refractive error which was not recorded in their statement. Despite additional visual needs being common, and described in clinical records, the majority of those with reduced vision and/or spectacle requirements did not have this information included in their statement. If visual limitations are not recognized by educational services, the child's needs may not be met during school life. More comprehensive eye care services, embedded with stakeholder communication and links to education are necessary to improve understanding of vision for children with neurological impairments. Copyright © 2014 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Operating Below Crush Depth: The Formation, Evolution, and Collapse of the Imperial Japanese Navy Submarine Force in World War II

DTIC Science & Technology

2011-06-10

Subamrine, Medium) LCDR Lieutenant Commander LT Lieutenant NM Nautical Mile RADM Rear Admiral ST Sen- Taka (Submarine, High Speed) STo Sen-Toku...Special Submarine) STS Sen- Taka -Sho (Submarine, High Speed(Victory)) USS United States Ship VADM Vice Admiral 1 CHAPTER 1 INTRODUCTION On...Kirai-Sen meaning Mine-Layer, KT for Kai-Toku-Chu meaning Medium, Special Submarine, ST for Sen- Taka meaning Submarine, High speed, STo for Sen Toku

The role of cross-group friendship and emotions in adolescents' attitudes towards inclusion.

PubMed

Grütter, Jeanine; Gasser, Luciano; Malti, Tina

2017-03-01

Most countries have started to educate students with special educational needs (SEN) in mainstream schools, but it remains unclear how inclusive attitudes towards students with SEN can be promoted. This study investigated the role of adolescents' friendships and socio-moral competencies for their attitudes towards the inclusion of students with SEN. Specifically, we studied whether adolescents without SEN would develop more inclusive attitudes if they had close friendships with SEN students and if they expressed negative emotions about social exclusion. Adolescents' inclusive attitudes and their emotions were gathered from survey data of 1225 Swiss students aged 11-13. Social network data were collected to assess adolescents' friendship relationships. The results indicated that adolescents' friendship closeness with SEN students positively related to their inclusive attitudes. However, this was only true for adolescents who anticipated more negative than positive emotions if a student with SEN was excluded. These findings highlight the role of friendship relationships between adolescents with and without SEN and adolescents' socio-moral experiences for their attitudes towards the inclusion of peers with SEN. Thus, inclusive education may benefit from promoting friendships among students with and without SEN as well as adolescents' socio-moral competencies. Copyright © 2017 Elsevier Ltd. All rights reserved.

Saccharomyces cerevisiae Sen1 Helicase Domain Exhibits 5'- to 3'-Helicase Activity with a Preference for Translocation on DNA Rather than RNA.

PubMed

Martin-Tumasz, Stephen; Brow, David A

2015-09-18

In the yeast Saccharomyces cerevisiae, the essential nuclear helicase Sen1 is required for efficient termination of transcription of short noncoding RNA genes by RNA polymerase II. However, the mechanism by which Sen1 promotes transcription termination is not known. Prior biochemical studies on the Sen1 homolog from Schizosaccharomyces pombe showed that it can bind and unwind both DNA and RNA, but the S. pombe protein is not essential and has not been demonstrated to function in transcription. Furthermore, Sen1 from either yeast has not previously been expressed as a recombinant protein, due to its large molecular mass (252 kDa in S. cerevisiae). Here, we report the purification and characterization of the 89-kDa S. cerevisiae Sen1 helicase domain (Sen1-HD) produced in Escherichia coli. Sen1-HD binds single-stranded RNA and DNA with similar affinity in the absence of ATP, but it binds RNA more stably than DNA in the presence of ATP, apparently due to a slower translocation rate on RNA. Translocation occurs in the 5' to 3' direction, as for the S. pombe protein. When purified from E. coli at a moderate salt concentration, Sen1-HD was associated with short RNAs that are enriched for the trinucleotide repeat (CAN)4. We propose that Sen1 binds to RNAs and prevents their stable pairing with DNA, consistent with in vivo studies by others showing increased R-loop (RNA/DNA hybrid) formation when Sen1 activity is impaired by mutations. Our results are consistent with a model in which Sen1 promotes transcription termination by resolving R-loops. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

The Lande-Kirkpatrick mechanism is the null model of evolution by intersexual selection: implications for meaning, honesty, and design in intersexual signals.

PubMed

Prum, Richard O

2010-11-01

The Fisher-inspired, arbitrary intersexual selection models of Lande (1981) and Kirkpatrick (1982), including both stable and unstable equilibrium conditions, provide the appropriate null model for the evolution of traits and preferences by intersexual selection. Like the Hardy–Weinberg equilibrium, the Lande–Kirkpatrick (LK) mechanism arises as an intrinsic consequence of genetic variation in trait and preference in the absence of other evolutionary forces. The LK mechanism is equivalent to other intersexual selection mechanisms in the absence of additional selection on preference and with additional trait-viability and preference-viability correlations equal to zero. The LK null model predicts the evolution of arbitrary display traits that are neither honest nor dishonest, indicate nothing other than mating availability, and lack any meaning or design other than their potential to correspond to mating preferences. The current standard for demonstrating an arbitrary trait is impossible to meet because it requires proof of the null hypothesis. The LK null model makes distinct predictions about the evolvability of traits and preferences. Examples of recent intersexual selection research document the confirmationist pitfalls of lacking a null model. Incorporation of the LK null into intersexual selection will contribute to serious examination of the extent to which natural selection on preferences shapes signals.

Revising Amartya Sen's Capability Approach to Education for Ethical Development

ERIC Educational Resources Information Center

Mok, Kwangsu; Jeong, Wongyu

2016-01-01

The purpose of this paper is to examine whether Amartya Sen's capability approach can suggest an appropriate theory of education for ethical development. Many advocates of Sen's capability approach insist that his approach is superior to rival theories of education, including the human capital theory. This is because Sen emphasizes the purpose and…

Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria.

PubMed

Yoshihisa, Tohru; Yunoki-Esaki, Kaori; Ohshima, Chie; Tanaka, Nobuyuki; Endo, Toshiya

2003-08-01

Pre-tRNA splicing has been believed to occur in the nucleus. In yeast, the tRNA splicing endonuclease that cleaves the exon-intron junctions of pre-tRNAs consists of Sen54p, Sen2p, Sen34p, and Sen15p and was thought to be an integral membrane protein of the inner nuclear envelope. Here we show that the majority of Sen2p, Sen54p, and the endonuclease activity are not localized in the nucleus, but on the mitochondrial surface. The endonuclease is peripherally associated with the cytosolic surface of the outer mitochondrial membrane. A Sen54p derivative artificially fixed on the mitochondria as an integral membrane protein can functionally replace the authentic Sen54p, whereas mutant proteins defective in mitochondrial localization are not fully active. sen2 mutant cells accumulate unspliced pre-tRNAs in the cytosol under the restrictive conditions, and this export of the pre-tRNAs partly depends on Los1p, yeast exportin-t. It is difficult to explain these results from the view of tRNA splicing in the nucleus. We rather propose a new possibility that tRNA splicing occurs on the mitochondrial surface in yeast.

Impact of the early detection of esophageal neoplasms in hypopharyngeal cancer patients treated with concurrent chemoradiotherapy.

PubMed

Watanabe, Shigenobu; Ogino, Ichiro; Inayama, Yoshiaki; Sugiura, Madoka; Sakuma, Yasunori; Kokawa, Atsushi; Kunisaki, Chikara; Inoue, Tomio

2017-04-01

We examined the risk factors and prognostic factors for synchronous esophageal neoplasia (SEN) by comparing the characteristics of hypopharyngeal cancer (HPC) patients with and without SEN. We examined 183 patients who were treated with definitive radiotherapy for HPC. Lugol chromoendoscopy screening of the esophagus was performed in all patients before chemoradiotherapy. Thirty-six patients had SEN, 49 patients died of HPC and two died of esophageal cancer. The patients with SEN exhibited significantly higher alcohol consumption than those without SEN (P = 0.018). The 5-year overall survival (OS) rate of the 36 patients with SEN was lower than that of the other patients (36.2% vs 63.4%, P = 0.006). The SEN patients exhibited significantly shorter HPC cause-specific survival than the other patients (P = 0.039). Both the OS (P = 0.005) and the HPC cause-specific survival (P = 0.026) of the patients with SEN were significantly shorter than those of the patients without SEN in multivariate analysis. Category 4/T1 stage esophageal cancer was treated with concurrent chemoradiotherapy (CCRT), endoscopic treatment or chemotherapy. The 5-year survival rates for esophageal cancer recurrence for CCRT, endoscopic treatment and chemotherapy were 71.5, 43.7 and 0%, respectively. The median (range) survival time (months) of CCRT, endoscopic treatment and chemotherapy was 22.7 (7.5-90.6), 46.44 (17.3-136.7) and 7.98 (3.72-22.8), respectively. Advanced HPC patients with SEN might have a poorer prognosis than those without SEN even when the esophageal cancer is detected early and managed appropriately. © 2014 Wiley Publishing Asia Pty Ltd.

Testing a Prototype for a New Cosmic Ray Particle Detector at the South Pole

NASA Astrophysics Data System (ADS)

Howell, R.; Rimsa, E.; Tharp, T.; Andeen, K.

2017-01-01

Cosmic ray research has grown rapidly in the past century, often using vacuum photomultiplier tubes (PMTs) to analyze the light produced by high-energy particles passing through scintillating material. Silicon photomultipliers (SiPMs) are now being recognized as a more efficient alternative to PMTs. Different types of photon events have been characterized using a SensL brand SiPM in combination with a QuarkNet Data Acquisition board. The goal of this study is to test the viability of the SiPM for a new generation surface detector at the South Pole.

Beyond tRNA cleavage: novel essential function for yeast tRNA splicing endonuclease unrelated to tRNA processing

PubMed Central

Dhungel, Nripesh; Hopper, Anita K.

2012-01-01

Pre-tRNA splicing is an essential process in all eukaryotes. In yeast and vertebrates, the enzyme catalyzing intron removal from pre-tRNA is a heterotetrameric complex (splicing endonuclease [SEN] complex). Although the SEN complex is conserved, the subcellular location where pre-tRNA splicing occurs is not. In yeast, the SEN complex is located at the cytoplasmic surface of mitochondria, whereas in vertebrates, pre-tRNA splicing is nuclear. We engineered yeast to mimic the vertebrate cell biology and demonstrate that all three steps of pre-tRNA splicing, as well as tRNA nuclear export and aminoacylation, occur efficiently when the SEN complex is nuclear. However, nuclear pre-tRNA splicing fails to complement growth defects of cells with defective mitochondrial-located splicing, suggesting that the yeast SEN complex surprisingly serves a novel and essential function in the cytoplasm that is unrelated to tRNA splicing. The novel function requires all four SEN complex subunits and the catalytic core. A subset of pre-rRNAs accumulates when the SEN complex is restricted to the nucleus, indicating that the SEN complex moonlights in rRNA processing. Thus, findings suggest that selection for the subcellular distribution of the SEN complex may reside not in its canonical, but rather in a novel, activity. PMID:22391451

The National Ignition Facility modular Kirkpatrick-Baez microscope.

PubMed

Pickworth, L A; Ayers, J; Bell, P; Brejnholt, N F; Buscho, J G; Bradley, D; Decker, T; Hau-Riege, S; Kilkenny, J; McCarville, T; Pardini, T; Vogel, J; Walton, C

2016-11-01

Current two-dimensional X-ray imaging at the National Ignition Facility (NIF) uses time resolved pinhole cameras with ∼10-25 μm pinholes. This method has limitations in the smallest resolvable features that can be imaged with reasonable photon statistics for inertial confinement fusion (ICF) applications. ICF sources have a broadband self-emission spectrum that causes the pinhole images obtained, through thin foil filters, to contain a similarly broadband spectrum complicating the interpretation of structure in the source. In order to study phenomena on the scale of ∼5 μm, such as dopant mix in the ICF capsule, a narrow energy band, higher spatial resolution microscope system with improved signal/noise has been developed using X-ray optics. Utilizing grazing incidence mirrors in a Kirkpatrick-Baez microscope (KBM) configuration [P. Kirkpatrick and A. V. Baez, J. Opt. Soc. Am. 38, 766-774 (1948)], an X-ray microscope has been designed and fielded on NIF with four imaging channels. The KBM has ∼12 × magnification, <8 μm resolution, and higher throughput in comparison to similar pinhole systems. The first KBM mirrors are coated with a multilayer mirror to allow a "narrow band" energy response at 10.2 keV with ΔE ∼ 3 keV. By adjusting the mirror coating only, the energy response can be matched to the future experimental requirements. Several mirror packs have been commissioned and are interchangeable in the diagnostic snout.

Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila

NASA Technical Reports Server (NTRS)

Nolo, R.; Abbott, L. A.; Bellen, H. J.

2000-01-01

The senseless (sens) gene is required for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS) of Drosophila. Sens is a nuclear protein with four Zn fingers that is expressed and required in the sensory organ precursors (SOP) for proper proneural gene expression. Ectopic expression of Sens in many ectodermal cells causes induction of PNS external sensory organ formation and is able to recreate an ectopic proneural field. Hence, sens is both necessary and sufficient for PNS development. Our data indicate that proneural genes activate sens expression. Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs.

Contribution of Salmonella Enteritidis virulence factors to intestinal colonization and systemic dissemination in 1-day-old chickens.

PubMed

Addwebi, Tarek M; Call, Douglas R; Shah, Devendra H

2014-04-01

Salmonella enterica serovar Enteritidis is one of the most common serovars associated with poultry and poultry product contamination in the United States. We previously identified 14 mutant strains of Salmonella Enteritidis phage type 4 (PT4) with significantly reduced invasiveness in human intestinal epithelial cells (Caco-2), chicken macrophages (HD-11), and chicken hepatocellular epithelial cells (LMH). These included Salmonella Enteritidis mutants with transposon insertions in 6 newly identified Salmonella Enteritidis-specific genes (pegD and SEN1393), and genes or genomic islands common to most other Salmonella serovars (SEN0803, SEN0034, SEN2278, and SEN3503) along with 8 genes previously known to contribute to enteric infection (hilA, pipA, fliH, fljB, csgB, spvR, and rfbMN). We hypothesized that Salmonella Enteritidis employs both common Salmonella enterica colonization factors and Salmonella Enteritidis-specific traits to establish infection in chickens. Four Salmonella Enteritidis mutants (SEN0034::Tn5, fliH::Tn5, SEN1393::Tn5, and spvR::Tn5) were indistinguishable from the isogenic wild-type strain when orally inoculated in 1-d-old chickens, whereas 2 mutants (CsgB::Tn5 and PegD::Tn5) were defective for intestinal colonization (P < 0.05) and 8 mutants (hilA::Tn5, SEN3503::Tn5, SEN0803::Tn5, SEN2278::Tn5, fljB::Tn5, rfbM::Tn5, rfbN::Tn5, and pipA::Tn5) showed significant in vivo attenuation in more than one organ (P < 0.05). Complementation studies confirmed the role of rfbN and SEN3503 during infection. This study should contribute to a better understanding of the mechanisms involved in Salmonella Enteritidis pathogenesis, and the target genes identified here could potentially serve as targets for the development of live-attenuated or subunit vaccine.

Phonon dispersion relation of Mg-Cu-Gd bulk metallic glasses

NASA Astrophysics Data System (ADS)

Suthar, P. H.

2016-05-01

Collective dynamics and elastic constants of bulk metallic glasses Mg65Cu25Gd10 and Mg60Cu25Gd15 are computed using the Hubbard -Beeby approach and our well recognized model potential. The important ingredients in the present study are the pair potential and local field correction functions (LFCF). The local field correction functions due to Hartree (H), Farid et al (F) and Sarkar Sen et al (S) are employed to investigation the influence of the screening effects on the longitudinal and traversed of phonon modes of glassy system. The results for the elastic constants are found to be in good agreement with experimental data.

Research methodology workshops evaluation using the Kirkpatrick's model: translating theory into practice.

PubMed

Abdulghani, Hamza Mohammad; Shaik, Shaffi Ahamed; Khamis, Nehal; Al-Drees, Abdulmajeed Abdulrahman; Irshad, Mohammad; Khalil, Mahmoud Salah; Alhaqwi, Ali Ibrahim; Isnani, Arthur

2014-04-01

Qualitative and quantitative evaluation of academic programs can enhance the development, effectiveness, and dissemination of comparative quality reports as well as quality improvement efforts. To evaluate the five research methodology workshops through assessing participants' satisfaction, knowledge and skills gain and impact on practices by the Kirkpatrick's evaluation model. The four level Kirkpatrick's model was applied for the evaluation. Training feedback questionnaires, pre and post tests, learner development plan reports and behavioral surveys were used to evaluate the effectiveness of the workshop programs. Of the 116 participants, 28 (24.1%) liked with appreciation, 62 (53.4%) liked with suggestions and 26 (22.4%) disliked the programs. Pre and post MCQs tests mean scores showed significant improvement of relevant basic knowledge and cognitive skills by 17.67% (p ≤ 0.005). Pre-and-post tests scores on workshops sub-topics also significantly improved for the manuscripts (p ≤ 0.031) and proposal writing (p ≤ 0.834). As for the impact, 56.9% of participants started research, and 6.9% published their studies. The results from participants' performance revealed an overall positive feedback and 79% of participant reported transfer of training skills at their workplace. The course outcomes achievement and suggestions given for improvements offer insight into the program which were encouraging and very useful. Encouraging "research culture" and work-based learning are probably the most powerful determinants for research promotion. These findings therefore encourage faculty development unit to continue its training and development in the research methodology aspects.

The National Ignition Facility modular Kirkpatrick-Baez microscope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pickworth, L. A., E-mail: pickworth1@llnl.gov; Ayers, J.; Bell, P.

Current two-dimensional X-ray imaging at the National Ignition Facility (NIF) uses time resolved pinhole cameras with ∼10-25 μm pinholes. This method has limitations in the smallest resolvable features that can be imaged with reasonable photon statistics for inertial confinement fusion (ICF) applications. ICF sources have a broadband self-emission spectrum that causes the pinhole images obtained, through thin foil filters, to contain a similarly broadband spectrum complicating the interpretation of structure in the source. In order to study phenomena on the scale of ∼5 μm, such as dopant mix in the ICF capsule, a narrow energy band, higher spatial resolution microscopemore » system with improved signal/noise has been developed using X-ray optics. Utilizing grazing incidence mirrors in a Kirkpatrick-Baez microscope (KBM) configuration [P. Kirkpatrick and A. V. Baez, J. Opt. Soc. Am. 38, 766–774 (1948)], an X-ray microscope has been designed and fielded on NIF with four imaging channels. The KBM has ∼12 × magnification, <8 μm resolution, and higher throughput in comparison to similar pinhole systems. The first KBM mirrors are coated with a multilayer mirror to allow a “narrow band” energy response at 10.2 keV with ΔE ∼ 3 keV. By adjusting the mirror coating only, the energy response can be matched to the future experimental requirements. Several mirror packs have been commissioned and are interchangeable in the diagnostic snout.« less

Capabilities and Choices: Do They Make Sen'se for Understanding Objective and Subjective Well-Being? An Empirical Test of Sen's Capability Framework on German and British Panel Data

ERIC Educational Resources Information Center

Muffels, Ruud; Headey, Bruce

2013-01-01

In Sen's Capability Approach (CA) well-being can be defined as the freedom of choice to achieve the things in life which one has reason to value most for his or her personal life. Capabilities are in Sen's vocabulary therefore the real freedoms people have or the opportunities available to them. In this paper we examine the impact of capabilities…

SEN virus infection in patients with hepatocellular carcinoma.

PubMed

Momosaki, S; Umemura, T; Scudamore, C H; Kojiro, M; Alter, H J; Tabor, E

2005-07-01

Although most cases of hepatocellular carcinoma (HCC) are associated with either the hepatitis B or C viruses (HBV, HCV), about 10-20% of HCCs occur in patients with chronic hepatitis that is aetiologically undefined. The aim of the present study was to determine the prevalence of the transfusion-transmitted SEN virus (SEN-V) in patients with HCC, including those patients who do not otherwise appear to be infected with HBV or HCV. Fragments of SEN-V subtypes D and H were amplified separately by PCR from the sera of 50 patients with HCC (31 from Canada and 19 from Japan) as well as from HCC and adjacent nontumourous liver tissues from eight of the Canadian patients. SEN-V DNA was found in the serum of 10 of 31 (32%) Canadian patients and eight of 19 (42%) Japanese patients [overall, 18 of 50 (36%) HCC patients]. SEN-V DNA was detected in the serum of 10 of 23 (43%) HCC patients with antibody to HCV (anti-HCV), six of 11 (55%) with hepatitis B surface antigen (HBsAg), and two of 16 (12%) without detectable anti-HCV or HBsAg. Twenty-three HCC patients in this study had 'silent HBV,' characterized by the detection of HBV DNA in the absence of HBsAg; eight of these (35%) also had SEN-V infections. SEN-V DNA was detected in HCC patients most typically in those with coexistent HBV or HCV infection. SEN-V was found in only one of seven HCC patients without HBV (without HBsAg or HBV DNA) or HCV and thus does not appear to be an important cause of 'cryptogenic' HCC.

Infection of Mice by Salmonella enterica Serovar Enteritidis Involves Additional Genes That Are Absent in the Genome of Serovar Typhimurium

PubMed Central

Silva, Cecilia A.; Blondel, Carlos J.; Quezada, Carolina P.; Porwollik, Steffen; Andrews-Polymenis, Helene L.; Toro, Cecilia S.; Zaldívar, Mercedes; Contreras, Inés

2012-01-01

Salmonella enterica serovar Enteritidis causes a systemic, typhoid-like infection in newly hatched poultry and mice. In the present study, a library of 54,000 transposon mutants of S. Enteritidis phage type 4 (PT4) strain P125109 was screened for mutants deficient in the in vivo colonization of the BALB/c mouse model using a microarray-based negative-selection screening. Mutants in genes known to contribute to systemic infection (e.g., Salmonella pathogenicity island 2 [SPI-2], aro, rfa, rfb, phoP, and phoQ) and enteric infection (e.g., SPI-1 and SPI-5) in this and other Salmonella serovars displayed colonization defects in our assay. In addition, a strong attenuation was observed for mutants in genes and genomic islands that are not present in S. Typhimurium or in most other Salmonella serovars. These genes include a type I restriction/modification system (SEN4290 to SEN4292), the peg fimbrial operon (SEN2144A to SEN2145B), a putative pathogenicity island (SEN1970 to SEN1999), and a type VI secretion system remnant SEN1001, encoding a hypothetical protein containing a lysin motif (LysM) domain associated with peptidoglycan binding. Proliferation defects for mutants in these individual genes and in exemplar genes for each of these clusters were confirmed in competitive infections with wild-type S. Enteritidis. A ΔSEN1001 mutant was defective for survival within RAW264.7 murine macrophages in vitro. Complementation assays directly linked the SEN1001 gene to phenotypes observed in vivo and in vitro. The genes identified here may perform novel virulence functions not characterized in previous Salmonella models. PMID:22083712

Senseless acts as a binary switch during sensory organ precursor selection

NASA Technical Reports Server (NTRS)

Jafar-Nejad, Hamed; Acar, Melih; Nolo, Riitta; Lacin, Haluk; Pan, Hongling; Parkhurst, Susan M.; Bellen, Hugo J.

2003-01-01

During sensory organ precursor (SOP) specification, a single cell is selected from a proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger transcription factor, plays an important role in this process. We show that Sens is directly activated by proneural proteins in the presumptive SOPs and a few cells surrounding the SOP in most tissues. In the cells that express low levels of Sens, it acts in a DNA-binding-dependent manner to repress transcription of proneural genes. In the presumptive SOPs that express high levels of Sens, it acts as a transcriptional activator and synergizes with proneural proteins. We therefore propose that Sens acts as a binary switch that is fundamental to SOP selection.

Assessment of the Self-Determination of Spanish Students with Intellectual Disabilities and other Educational Needs

PubMed Central

Gomez-Vela, Maria; Verdugo, Miguel Angel; Gonzalez Gil, Francisca; Corbella, Marta Badia; Wehmeyer, Michael L.

2014-01-01

The purpose of this study was to assess the self-determination of Spanish high school students with Intellectual Disability and other Special Educational Needs (SEN). A total of 371 students between 11 and 17 years of age participated in the study. Of these, 46.4% (n=171) presented SEN, specifically learning disabilities (n=97; 26.2%), borderline and intellectual disability with higher IQ scores (n=43; 11.6%) and mild intellectual disability (n=32; 8.6%). The remaining students without SEN made up the control group. The assessment was carried out using a translated and validated Spanish version of The Arc’s Self-Determination Scale (Wehmeyer, 1995). This measure had appropriate psychometric properties. Students with SEN obtained significantly lower scores than their peers without SEN. However, no differences were found in relation to the type of SEN or, more specifically, in relation to the presence of intellectual disability. The educational implications of the results are discussed. PMID:25057433

Capability through Participatory Democracy: Sen, Freire, and Dewey

ERIC Educational Resources Information Center

Glassman, Michael; Patton, Rikki

2014-01-01

This paper explores possible important relationships and sympathies between Amartya Sen's Capabilities Approach framework for understanding the human condition and the educational ideas of John Dewey and Paolo Freire. All three focus on the importance of democratic values in a fair, well-functioning society, while Sen and Freire especially…

Self-rated health and wellbeing among school-aged children with and without special educational needs: Differences between mainstream and special schools.

PubMed

Rathmann, Katharina; Vockert, Theres; Bilz, Ludwig; Gebhardt, Markus; Hurrelmann, Klaus

2018-05-11

Studies among students with special educational needs (SEN) in separate special schools (SSS) and mainstream schools (MS) are particularly applicable to educational attainment and social participation. However, indicators of health and wellbeing have rarely been considered. This study investigates two related topics: first, health and wellbeing differences between students with SEN in special schools (SSS) and students without SEN in regular schools, and second, the rarely considered question whether health and wellbeing among students with SEN differ between school settings (i.e. MS vs. SSS). Bivariate and multilevel analyses are applied with data from the German National Educational Panel Study (NEPS) with 5267 students (grade 7). After having controlled for background characteristics, students in SSS report higher likelihoods of poor self-rated health compared to students in higher track schools. Self-rated health of students with SEN does not significantly differ between MS vs. SSS. For life satisfaction, students with SEN show higher likelihoods of low life satisfaction when attending MS. Teachers in inclusive settings are encouraged to establish class work and teaching that support a real change from class placement to inclusive culture in order to suitably support students with SEN. Copyright © 2018 Elsevier Ltd. All rights reserved.

Utilization of a novel digital measurement tool for quantitative assessment of upper extremity motor dexterity: a controlled pilot study.

PubMed

Getachew, Ruth; Lee, Sunghoon I; Kimball, Jon A; Yew, Andrew Y; Lu, Derek S; Li, Charles H; Garst, Jordan H; Ghalehsari, Nima; Paak, Brian H; Razaghy, Mehrdad; Espinal, Marie; Ostowari, Arsha; Ghavamrezaii, Amir A; Pourtaheri, Sahar; Wu, Irene; Sarrafzadeh, Majid; Lu, Daniel C

2014-08-13

The current methods of assessing motor function rely primarily on the clinician's judgment of the patient's physical examination and the patient's self-administered surveys. Recently, computerized handgrip tools have been designed as an objective method to quantify upper-extremity motor function. This pilot study explores the use of the MediSens handgrip as a potential clinical tool for objectively assessing the motor function of the hand. Eleven patients with cervical spondylotic myelopathy (CSM) were followed for three months. Eighteen age-matched healthy participants were followed for two months. The neuromotor function and the patient-perceived motor function of these patients were assessed with the MediSens device and the Oswestry Disability Index respectively. The MediSens device utilized a target tracking test to investigate the neuromotor capacity of the participants. The mean absolute error (MAE) between the target curve and the curve tracing achieved by the participants was used as the assessment metric. The patients' adjusted MediSens MAE scores were then compared to the controls. The CSM patients were further classified as either "functional" or "nonfunctional" in order to validate the system's responsiveness. Finally, the correlation between the MediSens MAE score and the ODI score was investigated. The control participants had lower MediSens MAE scores of 8.09%±1.60%, while the cervical spinal disorder patients had greater MediSens MAE scores of 11.24%±6.29%. Following surgery, the functional CSM patients had an average MediSens MAE score of 7.13%±1.60%, while the nonfunctional CSM patients had an average score of 12.41%±6.32%. The MediSens MAE and the ODI scores showed a statistically significant correlation (r=-0.341, p<1.14×10⁻⁵). A Bland-Altman plot was then used to validate the agreement between the two scores. Furthermore, the percentage improvement of the the two scores after receiving the surgical intervention showed a significant correlation (r=-0.723, p<0.04). The MediSens handgrip device is capable of identifying patients with impaired motor function of the hand. The MediSens handgrip scores correlate with the ODI scores and may serve as an objective alternative for assessing motor function of the hand.

Broken Replica Symmetry Bounds in the Mean Field Spin Glass Model

NASA Astrophysics Data System (ADS)

Guerra, Francesco

By using a simple interpolation argument, in previous work we have proven the existence of the thermodynamic limit, for mean field disordered models, including the Sherrington-Kirkpatrick model, and the Derrida p-spin model. Here we extend this argument in order to compare the limiting free energy with the expression given by the Parisi Ansatz, and including full spontaneous replica symmetry breaking. Our main result is that the quenched average of the free energy is bounded from below by the value given in the Parisi Ansatz, uniformly in the size of the system. Moreover, the difference between the two expressions is given in the form of a sum rule, extending our previous work on the comparison between the true free energy and its replica symmetric Sherrington-Kirkpatrick approximation. We give also a variational bound for the infinite volume limit of the ground state energy per site.

Stability of the quantum Sherrington-Kirkpatrick spin glass model

NASA Astrophysics Data System (ADS)

Young, A. P.

2017-09-01

I study in detail the quantum Sherrington-Kirkpatrick (SK) model, i.e., the infinite-range Ising spin glass in a transverse field, by solving numerically the effective one-dimensional model that the quantum SK model can be mapped to in the thermodynamic limit. I find that the replica symmetric solution is unstable down to zero temperature, in contrast to some previous claims, and so there is not only a line of transitions in the (longitudinal) field-temperature plane (the de Almeida-Thouless, AT, line) where replica symmetry is broken, but also a quantum de Almeida-Thouless (QuAT) line in the transverse field-longitudinal field plane at T =0 . If the QuAT line also occurs in models with short-range interactions its presence might affect the performance of quantum annealers when solving spin glass-type problems with a bias (i.e., magnetic field).

Design a Learning-Oriented Fall Event Reporting System Based on Kirkpatrick Model.

PubMed

Zhou, Sicheng; Kang, Hong; Gong, Yang

2017-01-01

Patient fall has been a severe problem in healthcare facilities around the world due to its prevalence and cost. Routine fall prevention training programs are not as effective as expected. Using event reporting systems is the trend for reducing patient safety events such as falls, although some limitations of the systems exist at current stage. We summarized these limitations through literature review, and developed an improved web-based fall event reporting system. The Kirkpatrick model, widely used in the business area for training program evaluation, has been integrated during the design of our system. Different from traditional event reporting systems that only collect and store the reports, our system automatically annotates and analyzes the reported events, and provides users with timely knowledge support specific to the reported event. The paper illustrates the design of our system and how its features are intended to reduce patient falls by learning from previous errors.

Note: Tandem Kirkpatrick-Baez microscope with sixteen channels for high-resolution laser-plasma diagnostics

NASA Astrophysics Data System (ADS)

Yi, Shengzhen; Zhang, Zhe; Huang, Qiushi; Zhang, Zhong; Wang, Zhanshan; Wei, Lai; Liu, Dongxiao; Cao, Leifeng; Gu, Yuqiu

2018-03-01

Multi-channel Kirkpatrick-Baez (KB) microscopes, which have better resolution and collection efficiency than pinhole cameras, have been widely used in laser inertial confinement fusion to diagnose time evolution of the target implosion. In this study, a tandem multi-channel KB microscope was developed to have sixteen imaging channels with the precise control of spatial resolution and image intervals. This precise control was created using a coarse assembly of mirror pairs with high-accuracy optical prisms, followed by precise adjustment in real-time x-ray imaging experiments. The multilayers coated on the KB mirrors were designed to have substantially the same reflectivity to obtain a uniform brightness of different images for laser-plasma temperature analysis. The study provides a practicable method to achieve the optimum performance of the microscope for future high-resolution applications in inertial confinement fusion experiments.

Amartya Sen's Capability Approach and the Brokering of Learning Provision for Young Adults

ERIC Educational Resources Information Center

Harreveld, Roberta E.; Singh, Michael J.

2008-01-01

This paper argues that Amartya Sen's ("Development as freedom," New York: Random House, 1999) concept of "capabilities" provides a useful framework for interpreting the brokering of learning provisions that emerged as a key feature of reforms to education and training in Queensland (Australia) for young people. Sen's capability…

Diagnosis and Disengagement: Exploring the Disjuncture between SEN Policy and Practice

ERIC Educational Resources Information Center

McKay, Jane; Neal, Jayne

2009-01-01

Special Educational Needs (SEN) policy and practice in England and Wales currently relies on an authoritative and accurate diagnosis of need by professionals working in partnership with parents and children. Our analysis suggests there is a "continuum of disengagement" for children and young people with SEN. This will be used as a…

CD-sens can be a reliable and easy-to-use complement in the diagnosis of allergic rhinitis.

PubMed

Nopp, A; Cardell, L O; Johansson, S G O

2013-01-01

A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge. Twenty-six patients with a history of allergic rhinitis due to grass pollen were intranasally challenged and nasal symptom score and peak nasal inspiratory flow (PNIF) changes were determined after 15 min. A 20% decrease in PNIF or a symptom score ≥2 were considered a positive test. A blood sample for CD-sens was drawn before each challenge. Eighteen patients were tested twice. CD-sens agreed with the positive or negative nasal symptom score in 22/26 and PNIF in 24/26 patients. After the second challenge, 14/18 patients had the same symptom, 17/18 the same PNIF, while all had identical CD-sens classification. CD-sens appears to be a reproducible test for diagnosis of allergic rhinitis with great advantages also for follow-up of disease development and treatment effects. Copyright © 2012 S. Karger AG, Basel.

Successful management of severe cow's milk allergy with omalizumab treatment and CD-sens monitoring.

PubMed

Nilsson, Caroline; Nordvall, Lennart; Johansson, S G O; Nopp, Anna

2014-10-01

Food allergy is common in children and young adults and may be difficult to diagnose and is at present treated with avoidance of the food in question. The aim of this report is to share our clinical experiences monitoring omalizumab treatment by basophil allergen threshold sensitivity, CD-sens. Five children, 6-16 years of age, with a severe milk allergy including episodes of anaphylaxis and IgE-antibodies, between 30 and 160 kUA/L to casein and alpha-lactalbumin (milk proteins), were treated with omalizumab. CD-sens, was tested prior to and after 4 months of omalizumab and if turned negative, it was followed by an oral milk challenge. All children became negative in CD-sens and had a negative milk challenge, but one child required doubling of the omalizumab dose to achieve a negative CD-sens before a challenge was done. Omalizumab appears useful in treatment of severe food allergy, e.g., anaphylaxis to milk, and CD-sens monitoring may decide when and how to perform a food challenge.

Successful management of severe cow's milk allergy with omalizumab treatment and CD-sens monitoring

PubMed Central

Nilsson, Caroline; Nordvall, Lennart; Johansson, S.G.O.

2014-01-01

Food allergy is common in children and young adults and may be difficult to diagnose and is at present treated with avoidance of the food in question. The aim of this report is to share our clinical experiences monitoring omalizumab treatment by basophil allergen threshold sensitivity, CD-sens. Five children, 6-16 years of age, with a severe milk allergy including episodes of anaphylaxis and IgE-antibodies, between 30 and 160 kUA/L to casein and alpha-lactalbumin (milk proteins), were treated with omalizumab. CD-sens, was tested prior to and after 4 months of omalizumab and if turned negative, it was followed by an oral milk challenge. All children became negative in CD-sens and had a negative milk challenge, but one child required doubling of the omalizumab dose to achieve a negative CD-sens before a challenge was done. Omalizumab appears useful in treatment of severe food allergy, e.g., anaphylaxis to milk, and CD-sens monitoring may decide when and how to perform a food challenge. PMID:25379486

Rebooting Kirkpatrick: Integrating Information System Theory Into the Evaluation of Web-based Continuing Professional Development Interventions for Interprofessional Education.

PubMed

Shen, Nelson; Yufe, Shira; Saadatfard, Omid; Sockalingam, Sanjeev; Wiljer, David

2017-01-01

Information system research has stressed the importance of theory in understanding how user perceptions can motivate the use and adoption of technology such as web-based continuing professional development programs for interprofessional education (WCPD-IPE). A systematic review was conducted to provide an information system perspective on the current state of WCPD-IPE program evaluation and how current evaluations capture essential theoretical constructs in promoting technology adoption. Six databases were searched to identify studies evaluating WCPD-IPE. Three investigators determined eligibility of the articles. Evaluation items extracted from the studies were assessed using the Kirkpatrick-Barr framework and mapped to the Benefits Evaluation Framework. Thirty-seven eligible studies yielded 362 evaluation items for analysis. Most items (n = 252) were assessed as Kirkpatrick-Barr level 1 (reaction) and were mainly focused on the quality (information, service, and quality) and satisfaction dimensions of the Benefits Evaluation. System quality was the least evaluated quality dimension, accounting for 26 items across 13 studies. WCPD-IPE use was reported in 17 studies and its antecedent factors were evaluated in varying degrees of comprehensiveness. Although user reactions were commonly evaluated, greater focus on user perceptions of system quality (ie, functionality and performance), usefulness, and usability of the web-based platform is required. Surprisingly, WCPD-IPE use was reported in less than half of the studies. This is problematic as use is a prerequisite to realizing any individual, organizational, or societal benefit of WCPD-IPE. This review proposes an integrated framework which accounts for these factors and provides a theoretically grounded guide for future evaluations.

[Schedule for evaluation of the deficit syndrome in schizophrenia: Schedule for Deficit Syndrome (SDS) (Kirkpatrick et al.). Importance pertinence of the SDS. Introduction of the French version].

PubMed

Ribeyre, J M; Dollfus, S; Lesieur, P; Ménard, J F; Petit, M

1994-01-01

The negative symptoms of schizophrenia have generated a great interest leading some authors (Crow, Andreasen, Kay) to delineate schizophrenic subtypes based on their presence or absence. Carpenter et al. have recently proposed another subtype, the deficit syndrome, based on Kraepelin's clinical description. This differs from other proposed negative subtypes and refers to the presence or absence of prominent, enduring and primary negative symptoms. Primary negative symptoms have to be due to psychophrenia itself, in other words, independent of factors such as depression, anxiety, akinesia... Kirkpatrick et al. have proposed the Schedule for the Deficit Syndrome (SDS) to reliably identify this deficit syndrome. Some studies using this instrument have supported the validity of the deficit syndrome concept. Particularly, deficit patients have clinical, neuropsychological, neurological, eye-tracking and brain imaging impairments compared to nondeficit patients. We realized a french translation of SDS and used it to study a biological index (plasma homovanillic acid, pHVA) among deficit and nondeficit schizophrenic patients. Our data suggest a specific biochemical basis for the deficit syndrome, ie, significant lower mean pHVA levels with a lack of diurnal variation for deficit patients. The french version of SDS was validated by Kirkpatrick after english back translation. We present here our psychometric data regarding reliability (assessed by weighted and unweighted kappa coefficients) and cohesiveness of the construct (assessed by rank-order correlations of each negative symptoms with the other five, using Spearman's rho). These data are quite significant and in agreement with the SDS authors.

KSC-04PD-1561

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Sen. Bob Graham (back), D-Fla., former astronaut and Sen. John H. Glenn (front left), D-Ohio, Sen. John F. Kerry, D-Mass., and Sen. Bill Nelson, D-Fla., don clean room attire during a tour of the Orbiter Processing Facility (OPF). The bunny suits are required dress for anyone coming in close proximity to the orbiter Discovery, currently being prepared for flight on the next Space Shuttle mission. The tour of the OPF follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes Americas commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-04pd1561

NASA Image and Video Library

2004-07-26

KENNEDY SPACE CENTER, FLA. - Sen. Bob Graham (back), D-Fla., former astronaut and Sen. John H. Glenn (front left), D-Ohio, Sen. John F. Kerry, D-Mass., and Sen. Bill Nelson, D-Fla., don clean room attire during a tour of the Orbiter Processing Facility (OPF). The “bunny suits” are required dress for anyone coming in close proximity to the orbiter Discovery, currently being prepared for flight on the next Space Shuttle mission. The tour of the OPF follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes America’s commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

SensA: web-based sensitivity analysis of SBML models.

PubMed

Floettmann, Max; Uhlendorf, Jannis; Scharp, Till; Klipp, Edda; Spiesser, Thomas W

2014-10-01

SensA is a web-based application for sensitivity analysis of mathematical models. The sensitivity analysis is based on metabolic control analysis, computing the local, global and time-dependent properties of model components. Interactive visualization facilitates interpretation of usually complex results. SensA can contribute to the analysis, adjustment and understanding of mathematical models for dynamic systems. SensA is available at http://gofid.biologie.hu-berlin.de/ and can be used with any modern browser. The source code can be found at https://bitbucket.org/floettma/sensa/ (MIT license) © The Author 2014. Published by Oxford University Press.

[School well-being of students with and without special educational needs--a comparison of students in inclusive and regular classes].

PubMed

Schwab, Susanne; Rossmann, Peter; Tanzer, Norbert; Hagn, Joachim; Oitzinger, Sabrina; Thurner, Verena; Wimberger, Tanja

2015-07-01

The present study examines the academic well-being of students with and without special educational needs (SEN) in inclusive classes compared to students from regular classes in which no child with SEN is taught. In addition, the relationships between the school well-being and emotional problems, conduct problems, hyperactivity/inattention, peer relationship problems and prosocial behavior are analyzed. A total of 1115 students from the 4th and 7th grade (37 % 4th graders, 63 % 7th graders) participated in the survey, 126 of whom had been diagnosed as having SEN. The subscale Well-Being at School taken from the FEESS 3–4 (Rauer & Schuck, 2004) and the SDQ (Goodman, 1997) were used for measurement. Results indicate high reliabilities for the subscale Well-Being in School for students both with and without SEN for both grades 4 and 7. Furthermore, it could be shown that the variance explained for school well-being can be connected to elements on the students’ individual level as well as on the class-specific level. Significant predictors of school well-being were sex, behavioral difficulties and strengths as well as the school grade. The SEN status (no SEN vs. SEN) and the class setting (regular vs. inclusive class) did not influence the school well-being significantly.

The impact of contact on students' attitudes towards peers with disabilities.

PubMed

Schwab, Susanne

2017-03-01

This study aimed to understand the relationship between contact with peers with Special Educational Needs (SEN) and students' attitudes towards their peers with SEN, by examining the inter-group contact theory in regular and inclusive classes. A total of 463 students in 8th grade, with a mean age of 14.42 years, from 25 secondary school classes in Styria (Austria) completed a self-report questionnaire regarding their contact with peers with SEN and their attitudes towards peers with disabilities. Contact was indicated by nominations for joint activities and examined in inclusive and regular classes. The German short version of the Chedoke-McMaster Attitudes towards Children with Handicaps scale (CATCH; Schwab, 2015b; Rosenbaum et al., 1986) was used to measure students' attitudes towards peers with learning disabilities and emotional disorders. Students with SEN are less frequently nominated by their peers for joint activities, such as working together on a school project. Students from inclusive and regular classes did not differ in their attitudes towards peers with SEN. However, those students who nominated at least one peer with SEN for a joint activity had more positive attitudes towards peers with disabilities. Freely choosing contact with a peer with SEN was associated with more positive attitudes towards disability while simply attending the same class may have no effect or even a negative impact on students' attitudes. Copyright © 2017 Elsevier Ltd. All rights reserved.

Consultation, Negotiation and Compromise: The Relationship between SENCos, Parents and Pupils with SEN

ERIC Educational Resources Information Center

Maher, Anthony

2016-01-01

One outcome of the UK Government's commitment to inclusive educational policies was an increase in the number of pupils with special educational needs (SEN) being taught in mainstream schools. From the perspective of SENCos, this article analyses whether parents and pupils are able and willing to influence the development of SEN provision and…

The Politics of Meritocracy in Malaysia

DTIC Science & Technology

2003-12-01

required to address persistent inequalities. Amartya Sen argues that meritocracy is just an extension of a general system of rewarding merit...individuals toward the establishment of a better society. In this aspect, Sen perceived that any particular society would prefer a meritocractic system...situation. 108 Armartya Sen , Merit and Justice in Kenneth Arrow, Samuel Bowles and Steven Durlauf, eds., Meritocracy and

Emotional and Behavioural Difficulties (EBD): The Special Educational Need Justifying Exclusion

ERIC Educational Resources Information Center

Jull, Stephen K.

2008-01-01

Students identified with emotional and behavioural difficulties (EBD) present a special case within special educational needs (SEN) and inclusion. EBD is perhaps the only category of SEN that exposes a child to increased risk of exclusion as a function of the very SEN identified as requiring special provision in the first instance. Students…

Performance of an Early Infant Diagnostic Test, AmpliSens DNA-HIV-FRT, Using Dried Blood Spots Collected from Children Born to Human Immunodeficiency Virus-Infected Mothers in Ukraine

PubMed Central

Shanmugam, Vedapuri; Azarskova, Marianna; Nguyen, Shon; Hurlston, Mackenzie; Sabatier, Jennifer; Zhang, Guoqing; Osmanov, Saladin; Ellenberger, Dennis; Yang, Chunfu; Vitek, Charles; Liulchuk, Maria; Nizova, Natalya

2015-01-01

An accurate accessible test for early infant diagnosis (EID) is crucial for identifying HIV-infected infants and linking them to treatment. To improve EID services in Ukraine, dried blood spot (DBS) samples obtained from 237 HIV-exposed children (≤18 months of age) in six regions in Ukraine in 2012 to 2013 were tested with the AmpliSens DNA-HIV-FRT assay, the Roche COBAS AmpliPrep/COBAS TaqMan (CAP/CTM) HIV-1 Qual test, and the Abbott RealTime HIV-1 Qualitative assay. In comparison with the paired whole-blood results generated from AmpliSens testing at the oblast HIV reference laboratories in Ukraine, the sensitivity was 0.99 (95% confidence interval [CI], 0.95 to 1.00) for the AmpliSens and Roche CAP/CTM Qual assays and 0.96 (95% CI, 0.90 to 0.98) for the Abbott Qualitative assay. The specificity was 1.00 (95% CI, 0.97 to 1.00) for the AmpliSens and Abbott Qualitative assays and 0.99 (95% CI, 0.96 to 1.00) for the Roche CAP/CTM Qual assay. McNemar analysis indicated that the proportions of positive results for the tests were not significantly different (P > 0.05). Cohen's kappa (0.97 to 0.99) indicated almost perfect agreement among the three tests. These results indicated that the AmpliSens DBS and whole-blood tests performed equally well and were comparable to the two commercially available EID tests. More importantly, the performance characteristics of the AmpliSens DBS test meets the World Health Organization EID test requirements; implementing AmpliSens DBS testing might improve EID services in resource-limited settings. PMID:26447114

Pupils with special educational needs in basic education schools and teachers' sickness absences--a register-linkage study.

PubMed

Ervasti, Jenni; Kivimäki, Mika; Kawachi, Ichiro; Subramanian, S V; Pentti, Jaana; Ahola, Kirsi; Oksanen, Tuula; Pohjonen, Tiina; Vahtera, Jussi; Virtanen, Marianna

2012-05-01

We examined whether having a high percentage of pupils with special educational needs (SEN) in basic education schools increases the risk of sickness absence among teachers and whether this risk is dependent on the pupil-teacher ratio (PTR), an indicator of teacher resources at school. We obtained register data on 8089 teachers working in 404 schools in 10 municipalities in Finland during the school year 2004-2005. We used multilevel multinomial regression models to examine the risk of teachers' short- and long-term sickness absence in relation to the percentage of SEN pupils and the PTR at school. We tested the equality of trends in groups with high and low PTR using PTR × SEN interaction term. After adjustment for teacher and school characteristics, the risk for long-term absences was higher among teachers at schools with a high percentage of SEN pupils than among teachers at schools with a low percentage of SEN pupils [odds ratio (OR) 1.5, 95% confidence interval (95% CI) 1.2-1.8). This was also the case for short-term absences (OR 1.4, 95% CI 1.2-1.7). In analyses stratified by the PTR levels, the association between the percentage of SEN pupils and long-term absences was 15% higher among teachers with a high PTR than among those with a low PTR (P for interaction=0.10). Teachers' sickness absenteeism seems to increase with a higher percentage of SEN pupils, especially when the PTR is high. Teacher resources at schools that have a high percentage of SEN pupils should be well maintained to ensure the health of teachers.

Characterization of putative virulence factors of Serratia marcescens strain SEN for pathogenesis in Spodoptera litura.

PubMed

Aggarwal, Chetana; Paul, Sangeeta; Tripathi, Vishwas; Paul, Bishwajeet; Khan, Md Aslam

2017-02-01

Two Serratia marcescens strains, SEN and ICC-4, isolated from diseased insect cadavers were observed to differ considerably in their virulence towards Spodoptera litura. The present study was aimed to characterize the possible virulence factors present in the virulent Serratia marcescens strain SEN. Both the S. marcescens strains were evaluated for the presence of various lytic enzymes such as chitinase, lipase, protease and phospholipase. The virulent S. marcescens strain SEN was observed to possess considerably higher activity of chitinase and protease enzymes; activity of phospholipase enzyme was also higher. Although, all the three toxin genes shlA, phlA and swr could be detected in both the S. marcescens strains, there was a higher expression of these genes in the virulent strain SEN. S. marcescens strain ICC-4 showed greater reduction in overall growth yield in the post-exponential phase in the presence of midgut juice and hemolymph of S. litura larvae, as compared to S. marcescens strain SEN. Proliferation of the S. marcescens strain SEN was also considerably higher in foregut, midgut and hemolymph of S. litura larvae, as compared to strain ICC-4. Peritrophic membrane treated with broth culture of the S. marcescens strain SEN showed higher damage as compared to strain ICC-4. The peritrophic membrane of larvae fed on diet treated with the virulent strain showed considerable damage while the peritrophic membrane of larvae fed on diet treated with the non-virulent strain showed no damage. This is the first report documenting the fate of ingested S. marcescens in S. litura gut and the relative expression of toxin genes from two S. marcescens strains differing in their virulence towards S. litura. Copyright © 2016 Elsevier Inc. All rights reserved.

Three-Dimensional Flow Behavior Inside the Submerged Entry Nozzle

NASA Astrophysics Data System (ADS)

Real-Ramirez, Cesar Augusto; Carvajal-Mariscal, Ignacio; Sanchez-Silva, Florencio; Cervantes-de-la-Torre, Francisco; Diaz-Montes, Jesus; Gonzalez-Trejo, Jesus

2018-05-01

According to various authors, the surface quality of steel depends on the dynamic conditions that occur within the continuous casting mold's upper region. The meniscus, found in that upper region, is where the solidification process begins. The liquid steel is distributed into the mold through a submerged entry nozzle (SEN). In this paper, the dynamic behavior inside the SEN is analyzed by means of physical experiments and numerical simulations. The particle imaging velocimetry technique was used to obtain the vector field in different planes and three-dimensional flow patterns inside the SEN volume. Moreover, large eddy simulation was performed, and the turbulence model results were used to understand the nonlinear flow pattern inside the SEN. Using scaled physical and numerical models, quasi-periodic behavior was observed due to the interaction of two three-dimensional vortices that move inside the SEN lower region located between the exit ports of the nozzle.

Development and quality of life: a critique of Amartya Sen's Development as freedom.

PubMed

Navarro, V

2000-01-01

Presented here is a critical analysis of some of the major theses of Amartya Sen, as presented in his seminal work Development As Freedom. The author suggests that Sen's work, while representing a major break with the dominant neoliberal position reproduced in most national and international development agencies, is insufficient to explain the key relationship between freedom and development. The absence of an analysis of the power relations that cause and reproduce underdevelopment through national and international political institutions leaves Sen's work wanting. The author shows how Sen's interpretation of events and the conclusions derived from them, such as an explanation of famine in Bangladesh, are insufficient--when not faulty. The author also critically analyzes the United Nations Development Program reports, which, while documenting the nature and consequences of underdevelopment, barely touch on the political context in which underdevelopment occurs.

Transformative Educational Actions for Children in Poverty: Sen's Capability Approach into Practice in the Korean Context

ERIC Educational Resources Information Center

Kim, Kyung Hi

2017-01-01

By adopting Sen's capability approach, this study explores transformative educational actions for children in poverty to develop their capabilities for learning for life. Sen's capability approach provides a framework for why it is important to foster the capabilities of children in poverty and what is required to help these children to improve…

Social dimensions of inclusion in education of 4th and 7th grade pupils in inclusive and regular classes: Outcomes from Austria.

PubMed

Schwab, Susanne

2015-01-01

Positive peer relationships play a significant role in the development of students. They are beneficial for learning and psychological outcomes. This article draws upon an important distinction between the four main themes of social participation (friendships, interactions, peer acceptance and self-perception of social participation) and examines these aspects in inclusive and regular classes. Especially, differences in social participation of students with and without special educational needs (SEN) in inclusive classes and between students without SEN in inclusive and regular classes are examined. In this study, data from 1115 pupils in primary and secondary schools in Austria were analysed, of which 129 were diagnosed as having SEN. The results showed that in inclusive classes, students with SEN had lower scores on all four subthemes of social participation (friendships, interactions, peer acceptance and self-perception of social integration) than students without SEN. Regarding students without SEN, friendships and peer acceptance were significantly higher in inclusive classes than in regular classes. Differences were neither found for gender, nor between primary and secondary school students. Copyright © 2015 Elsevier Ltd. All rights reserved.

Peripheral tactile sensory perception of older adults improved using subsensory electrical noise stimulation.

PubMed

Breen, Paul P; Serrador, Jorge M; O'Tuathail, Claire; Quinlan, Leo R; McIntosh, Caroline; ÓLaighin, Gearóid

2016-08-01

Loss of tactile sensory function is common with aging and can lead to numbness and difficulty with balance and gait. In previous work we found that subsensory electrical noise stimulation (SENS) applied to the tibial nerve improved tactile perception in the soles of the feet of healthy adults. In this work we aimed to determine if SENS remained effective in an older adult population with significant levels of sensory loss. Older adult subjects (N=8, female = 4, aged 65-80) had SENS applied via surface electrodes placed proximally to the medial and lateral malleoli. Vibration perception thresholds (VPTs) were assessed in six conditions, two control conditions (no SENS) and four SENS conditions (zero mean ±15µA, 30µA, 45µA and 60µA SD). VPT was assessed at three sites on the plantar aspect of the foot. Vibration perception was significantly improved in the presence of ±30µA SENS and by 16.2±2.4% (mean ± s.e.m.) when optimised for each subject. The improvement in perception was similar across all VPT test sites. Copyright © 2016 IPEM. All rights reserved.

A pilot study of sensory feedback by transcutaneous electrical nerve stimulation to improve manipulation deficit caused by severe sensory loss after stroke

PubMed Central

2013-01-01

Background Sensory disturbance is common following stroke and can exacerbate functional deficits, even in patients with relatively good motor function. In particular, loss of appropriate sensory feedback in severe sensory loss impairs manipulation capability. We hypothesized that task-oriented training with sensory feedback assistance would improve manipulation capability even without sensory pathway recovery. Methods We developed a system that provides sensory feedback by transcutaneous electrical nerve stimulation (SENS) for patients with sensory loss, and investigated the feasibility of the system in a stroke patient with severe sensory impairment and mild motor deficit. The electrical current was modulated by the force exerted by the fingertips so as to allow the patient to identify the intensity. The patient had severe sensory loss due to a right thalamic hemorrhage suffered 27 months prior to participation in the study. The patient first practiced a cylindrical grasp task with SENS for 1 hour daily over 29 days. Pressure information from the affected thumb was fed back to the unaffected shoulder. The same patient practiced a tip pinch task with SENS for 1 hour daily over 4 days. Pressure information from the affected thumb and index finger was fed back to the unaffected and affected shoulders, respectively. We assessed the feasibility of SENS and examined the improvement of manipulation capability after training with SENS. Results The fluctuation in fingertip force during the cylindrical grasp task gradually decreased as the training progressed. The patient was able to maintain a stable grip force after training, even without SENS. Pressure exerted by the tip pinch of the affected hand was unstable before intervention with SENS compared with that of the unaffected hand. However, they were similar to each other immediately after SENS was initiated, suggesting that the somatosensory information improved tip pinch performance. The patient’s manipulation capability assessed by the Box and Block Test score improved through SENS intervention and was partly maintained after SENS was removed, until at least 7 months after the intervention. The sensory test score, however, showed no recovery after intervention. Conclusions We conclude that the proposed system would be useful in the rehabilitation of patients with sensory loss. PMID:23764012

A pilot study of sensory feedback by transcutaneous electrical nerve stimulation to improve manipulation deficit caused by severe sensory loss after stroke.

PubMed

Kita, Kahori; Otaka, Yohei; Takeda, Kotaro; Sakata, Sachiko; Ushiba, Junichi; Kondo, Kunitsugu; Liu, Meigen; Osu, Rieko

2013-06-13

Sensory disturbance is common following stroke and can exacerbate functional deficits, even in patients with relatively good motor function. In particular, loss of appropriate sensory feedback in severe sensory loss impairs manipulation capability. We hypothesized that task-oriented training with sensory feedback assistance would improve manipulation capability even without sensory pathway recovery. We developed a system that provides sensory feedback by transcutaneous electrical nerve stimulation (SENS) for patients with sensory loss, and investigated the feasibility of the system in a stroke patient with severe sensory impairment and mild motor deficit. The electrical current was modulated by the force exerted by the fingertips so as to allow the patient to identify the intensity. The patient had severe sensory loss due to a right thalamic hemorrhage suffered 27 months prior to participation in the study. The patient first practiced a cylindrical grasp task with SENS for 1 hour daily over 29 days. Pressure information from the affected thumb was fed back to the unaffected shoulder. The same patient practiced a tip pinch task with SENS for 1 hour daily over 4 days. Pressure information from the affected thumb and index finger was fed back to the unaffected and affected shoulders, respectively. We assessed the feasibility of SENS and examined the improvement of manipulation capability after training with SENS. The fluctuation in fingertip force during the cylindrical grasp task gradually decreased as the training progressed. The patient was able to maintain a stable grip force after training, even without SENS. Pressure exerted by the tip pinch of the affected hand was unstable before intervention with SENS compared with that of the unaffected hand. However, they were similar to each other immediately after SENS was initiated, suggesting that the somatosensory information improved tip pinch performance. The patient's manipulation capability assessed by the Box and Block Test score improved through SENS intervention and was partly maintained after SENS was removed, until at least 7 months after the intervention. The sensory test score, however, showed no recovery after intervention. We conclude that the proposed system would be useful in the rehabilitation of patients with sensory loss.

A comparative study of two-piece ostomy appliances.

PubMed

Welser, Marion; Riedlinger, Inge; Prause, Ulla

The quality of life of people with a stoma may be affected by peristomal skin disorders and by frequent unplanned changes of ostomy appliances due to problems with those appliances. The aim of this study was to evaluate two new, two-piece ostomy appliances with mechanical couplings (both from the SenSura range by Coloplast) and their ability to address areas that may be important to the quality of life of people with stomas, including appliance changes, stool seepage and overfilling. The study design featured two comparative, crossover, randomized multi-centre studies that were conducted in Germany. The SenSura appliances were evaluated against established reference appliances. Seventy-three individuals with a colostomy (closed-end appliances) and 75 individuals with an ileostomy (drainable appliances) participated in the studies. The participants tested 4-6 flanges of each type within a maximum period of two weeks. The results demonstrated that there was less seepage of stool observed under the SenSura flange when it was removed (p<0.05). Also, there were fewer unplanned changes (p<0.0005) seen with SenSura than with the reference appliances. The SenSura flanges had better adhesion and flexibility and were easier to remove than the references (p<0.0005), and they had greater resistance to erosion (p<0.05). In conclusion, SenSura performed better than the reference appliances on quality of life indicators - there were fewer unplanned changes and less seepage of stool was observed in patients using the SenSura products.

Evaluation That Goes the Distance.

ERIC Educational Resources Information Center

Bernthal, Paul R.

1995-01-01

A modification of Donald Kirkpatrick's model suggests use of a training-impact tree to identify variables that could establish links between training and organizational values. Steps include identifying organizational values and practices; identifying skills, knowledge, and attitudes; defining scope and purpose of evaluation; gathering data; and…

Globalization and State Soverignty

DTIC Science & Technology

2003-04-07

ENDNOTES 1 Amartya Sen (Noble Award Winner), “A World of Extremes: Ten Theses on Globalization,” Los Angeles Times, 17 July 2001, available from <http...Sylvia., “Globalization and the Nation States: Erosion from Above”, Timlin Lecture, University of Saskatchewan, February 1998. Sen , Amartya . (Noble...New York, January/ February 2001, available from http://proquest.umi.com; Internet; accessed 11 February 2003. 9 Hirst and Thompson. 10 Sen . 11 United

Afghanistan’s Local War: Building Local Defense Forces

DTIC Science & Technology

2010-01-01

Afghanistan’s Local War: Building Local Defense Forces economic and other development conditions. As the Nobel Prize- winning economist Amartya Sen ...strengthen warlords 9 Amartya Sen , Development as Freedom, New York: Anchor Books, 2000, p. 11. Mitigating Risks 77 • weaken central government forces...Taliban Afghanistan, Bonn: Bonn International Center for Conversion, 2002. Sen , Amartya , Development as Freedom, New York: Anchor Books, 2000. Shahrani

Social Relationships of Pupils with Special Educational Needs in the Mainstream Primary Class: Peer Group Membership and Peer-Assessed Social Behaviour

ERIC Educational Resources Information Center

Avramidis, Elias

2010-01-01

One of the major aims for the inclusion of pupils with special educational needs (SEN) within the mainstream classroom is to reduce prejudice and increase social interaction among children. Nevertheless, research has consistently shown that pupils with SEN remain less accepted by and may experience greater loneliness than their non-SEN peers. This…

Inclusion and the Special Educational Needs (SEN) Resource Base in Mainstream Schools: Physical Factors to Maximise Effectiveness

ERIC Educational Resources Information Center

McAllister, Keith; Hadjri, Karim

2013-01-01

As a society, we have a responsibility to provide an inclusive built environment. As part of the need to promote inclusion, there is now a growing trend to place pupils with special educational needs (SEN) into a mainstream school setting. This is often facilitated by providing a specialist SEN resource base located within the mainstream school.…

Quantitative computed tomography applied to interstitial lung diseases.

PubMed

Obert, Martin; Kampschulte, Marian; Limburg, Rebekka; Barańczuk, Stefan; Krombach, Gabriele A

2018-03-01

To evaluate a new image marker that retrieves information from computed tomography (CT) density histograms, with respect to classification properties between different lung parenchyma groups. Furthermore, to conduct a comparison of the new image marker with conventional markers. Density histograms from 220 different subjects (normal = 71; emphysema = 73; fibrotic = 76) were used to compare the conventionally applied emphysema index (EI), 15 th percentile value (PV), mean value (MV), variance (V), skewness (S), kurtosis (K), with a new histogram's functional shape (HFS) method. Multinomial logistic regression (MLR) analyses was performed to calculate predictions of different lung parenchyma group membership using the individual methods, as well as combinations thereof, as covariates. Overall correct assigned subjects (OCA), sensitivity (sens), specificity (spec), and Nagelkerke's pseudo R 2 (NR 2 ) effect size were estimated. NR 2 was used to set up a ranking list of the different methods. MLR indicates the highest classification power (OCA of 92%; sens 0.95; spec 0.89; NR 2 0.95) when all histogram analyses methods were applied together in the MLR. Highest classification power among individually applied methods was found using the HFS concept (OCA 86%; sens 0.93; spec 0.79; NR 2 0.80). Conventional methods achieved lower classification potential on their own: EI (OCA 69%; sens 0.95; spec 0.26; NR 2 0.52); PV (OCA 69%; sens 0.90; spec 0.37; NR 2 0.57); MV (OCA 65%; sens 0.71; spec 0.58; NR 2 0.61); V (OCA 66%; sens 0.72; spec 0.53; NR 2 0.66); S (OCA 65%; sens 0.88; spec 0.26; NR 2 0.55); and K (OCA 63%; sens 0.90; spec 0.16; NR 2 0.48). The HFS method, which was so far applied to a CT bone density curve analysis, is also a remarkable information extraction tool for lung density histograms. Presumably, being a principle mathematical approach, the HFS method can extract valuable health related information also from histograms from complete different areas. Copyright © 2018 Elsevier B.V. All rights reserved.

Analysis of Six Reviews on the Quality of Instruments for the Evaluation of Interprofessional Education in German-Speaking Countries.

PubMed

Ehlers, Jan P; Kaap-Fröhlich, Sylvia; Mahler, Cornelia; Scherer, Theresa; Huber, Marion

2017-01-01

Background: More and more institutions worldwide and in German-speaking countries are developing and establishing interprofessional seminars in undergraduate education of health professions. In order to evaluate the different didactic approaches and different outcomes regarding the anticipated interprofessional competencies, it is necessary to apply appropriate instruments. Cross-cultural instruments are particularly helpful for international comparability. The Interprofessional Education working group of the German Medical Association (GMA) aims at identifying existing instruments for the evaluation of interprofessional education in order to make recommendations for German-speaking countries. Methods: Systematic literature research was performed on the websites of international interprofessional organisations (CAIPE, EIPEN, AIPEN), as well as in the PubMed and Cinahl databases. Reviews focusing on quantitative instruments to evaluate competencies according to the modified Kirkpatrick competency levels were searched for. Psychometrics, language/country and setting, in which the instrument was applied, were recorded. Results: Six reviews out of 73 literature research hits were included. A large number of instruments were identified; however, their psychometrics and the applied setting were very heterogeneous. The instruments can mainly be assigned to Kirkpatrick levels 1, 2a & 2b. Most instruments have been developed in English but their psychometrics were not always reported rigorously. Only very few instruments are available in German. Conclusion: It is difficult to find appropriate instruments in German. Internationally, there are different approaches and objectives in the measurement and evaluation of interprofessional competencies. The question arises whether it makes sense to translate existing instruments or to go through the lengthy process of developing new ones. The evaluation of interprofessional seminars with quantitative instruments remains mainly on Kirkpatrick levels 1 and 2. Levels 3 and 4 can probably only be assessed with qualitative or mixed methods. German language instruments are necessary.

Analysis of Six Reviews on the Quality of Instruments for the Evaluation of Interprofessional Education in German-Speaking Countries

PubMed Central

Ehlers, Jan P.; Kaap-Fröhlich, Sylvia; Mahler, Cornelia; Scherer, Theresa; Huber, Marion

2017-01-01

Background: More and more institutions worldwide and in German-speaking countries are developing and establishing interprofessional seminars in undergraduate education of health professions. In order to evaluate the different didactic approaches and different outcomes regarding the anticipated interprofessional competencies, it is necessary to apply appropriate instruments. Cross-cultural instruments are particularly helpful for international comparability. The Interprofessional Education working group of the German Medical Association (GMA) aims at identifying existing instruments for the evaluation of interprofessional education in order to make recommendations for German-speaking countries. Methods: Systematic literature research was performed on the websites of international interprofessional organisations (CAIPE, EIPEN, AIPEN), as well as in the PubMed and Cinahl databases. Reviews focusing on quantitative instruments to evaluate competencies according to the modified Kirkpatrick competency levels were searched for. Psychometrics, language/country and setting, in which the instrument was applied, were recorded. Results: Six reviews out of 73 literature research hits were included. A large number of instruments were identified; however, their psychometrics and the applied setting were very heterogeneous. The instruments can mainly be assigned to Kirkpatrick levels 1, 2a & 2b. Most instruments have been developed in English but their psychometrics were not always reported rigorously. Only very few instruments are available in German. Conclusion: It is difficult to find appropriate instruments in German. Internationally, there are different approaches and objectives in the measurement and evaluation of interprofessional competencies. The question arises whether it makes sense to translate existing instruments or to go through the lengthy process of developing new ones. The evaluation of interprofessional seminars with quantitative instruments remains mainly on Kirkpatrick levels 1 and 2. Levels 3 and 4 can probably only be assessed with qualitative or mixed methods. German language instruments are necessary. PMID:28890927

New and existing combinations in Palaeotropical Phlegmariurus (Lycopodiaceae) and lectotypification of the type species Phlegmariurus phlegmaria (L.) T.Sen & U.Sen.

PubMed Central

Field, Ashley R.; Bostock, Peter D.

2013-01-01

Abstract The genus Phlegmariurus Holubis recognised more widely than originally proposed and is circumscribed to include both Neotropic and Palaeotropic epiphytic and terrestrial species of Huperzioid Lycopodiaceae that have isotomous shoots, lack bulbils in their sporophyllous shoots and have spores with convex lateral margins and foveolate-fossulate sculpture restricted to their distal surfaces. New combinations with Phlegmariurus are proposed for 81 species and existing combinations identified for 33 species originating from the Palaeotropics. This installs a generic circumscription that is consistent between the Neotropics and Palaeotropics. A lectotype is designated for the type species of the genus, Phlegmariurus phlegmaria (L.) T.Sen & U.Sen PMID:23730196

SenSyF Experience on Integration of EO Services in a Generic, Cloud-Based EO Exploitation Platform

NASA Astrophysics Data System (ADS)

Almeida, Nuno; Catarino, Nuno; Gutierrez, Antonio; Grosso, Nuno; Andrade, Joao; Caumont, Herve; Goncalves, Pedro; Villa, Guillermo; Mangin, Antoine; Serra, Romain; Johnsen, Harald; Grydeland, Tom; Emsley, Stephen; Jauch, Eduardo; Moreno, Jose; Ruiz, Antonio

2016-08-01

SenSyF is a cloud-based data processing framework for EO- based services. It has been pioneer in addressing Big Data issues from the Earth Observation point of view, and is a precursor of several of the technologies and methodologies that will be deployed in ESA's Thematic Exploitation Platforms and other related systems.The SenSyF system focuses on developing fully automated data management, together with access to a processing and exploitation framework, including Earth Observation specific tools. SenSyF is both a development and validation platform for data intensive applications using Earth Observation data. With SenSyF, scientific, institutional or commercial institutions developing EO- based applications and services can take advantage of distributed computational and storage resources, tailored for applications dependent on big Earth Observation data, and without resorting to deep infrastructure and technological investments.This paper describes the integration process and the experience gathered from different EO Service providers during the project.

Operationalizing Economics for Counterinsurgency and Stability Operations

DTIC Science & Technology

2009-05-01

as freedom, described by Amartya Sen provides an improved foundation for military operations and a more complete campaign framework. Within these...peacekeeping.7 Development described by Amartya Sen is based on a concept that promotes freedom, a cornerstone of democracy and U.S. national policy. The...poverty and disease promote state failure.19 The writings of Jeffery Sachs, Thomas Sowell, Paul Collier, Amartya Sen , the World Bank, and many others

Breaking the Failed-State Cycle

DTIC Science & Technology

2008-01-01

Perhaps this focus on human industry is obvious—for instance, Amartya Sen argues for a freedom-centered, agent-oriented view of development10—but...endowed with productive populations but few natural resources, such as Singapore. 10 Amartya Sen , Development as Freedom, New York: Anchor Books, 1999. 5...ArchiveID=16328 Sen , Amartya , Development as Freedom, New York: Anchor Books, 1999. U.S. Department of Defense, Office of the Assistant Secretary of

Variable magnification with Kirkpatrick-Baez optics for synchrotron X-ray microscopy

DOE PAGES

Jach, Terrence; Bakulin, Alex S.; Durbin, Stephen M.; ...

2006-05-01

In this study, we describe the distinction between the operation of a short focal length x-ray microscope forming a real image with a laboratory source (convergent illumination) and with a highly collimated intense beam from a synchrotron light source (Kohler illumination).

Applying the Kirkpatrick Model: Evaluating an "Interaction for Learning Framework" Curriculum Intervention

ERIC Educational Resources Information Center

Paull, Megan; Whitsed, Craig; Girardi, Antonia

2016-01-01

Global perspectives and interpersonal and intercultural communication competencies are viewed as a priority within higher education. For management educators, globalisation, student mobility and widening pathways present numerous challenges, but afford opportunities for curriculum innovation. The "Interaction for Learning Framework"…

VineSens: An Eco-Smart Decision-Support Viticulture System

PubMed Central

Pérez-Expósito, Josman P.; Fernández-Caramés, Tiago M.; Fraga-Lamas, Paula; Castedo, Luis

2017-01-01

This article presents VineSens, a hardware and software platform for supporting the decision-making of the vine grower. VineSens is based on a wireless sensor network system composed by autonomous and self-powered nodes that are deployed throughout a vineyard. Such nodes include sensors that allow us to obtain detailed knowledge on different viticulture processes. Thanks to the use of epidemiological models, VineSens is able to propose a custom control plan to prevent diseases like one of the most feared by vine growers: downy mildew. VineSens generates alerts that warn farmers about the measures that have to be taken and stores the historical weather data collected from different spots of the vineyard. Such data can then be accessed through a user-friendly web-based interface that can be accessed through the Internet by using desktop or mobile devices. VineSens was deployed at the beginning in 2016 in a vineyard in the Ribeira Sacra area (Galicia, Spain) and, since then, its hardware and software have been tested to prevent the development of downy mildew, showing during its first season that the system can led to substantial savings, to decrease the amount of phytosanitary products applied, and, as a consequence, to obtain a more ecologically sustainable and healthy wine. PMID:28245619

VineSens: An Eco-Smart Decision-Support Viticulture System.

PubMed

Pérez-Expósito, Josman P; Fernández-Caramés, Tiago M; Fraga-Lamas, Paula; Castedo, Luis

2017-02-25

This article presents VineSens, a hardware and software platform for supporting the decision-making of the vine grower. VineSens is based on a wireless sensor network system composed by autonomous and self-powered nodes that are deployed throughout a vineyard. Such nodes include sensors that allow us to obtain detailed knowledge on different viticulture processes. Thanks to the use of epidemiological models, VineSens is able to propose a custom control plan to prevent diseases like one of the most feared by vine growers: downy mildew. VineSens generates alerts that warn farmers about the measures that have to be taken and stores the historical weather data collected from different spots of the vineyard. Such data can then be accessed through a user-friendly web-based interface that can be accessed through the Internet by using desktop or mobile devices. VineSens was deployed at the beginning in 2016 in a vineyard in the Ribeira Sacra area (Galicia, Spain) and, since then, its hardware and software have been tested to prevent the development of downy mildew, showing during its first season that the system can led to substantial savings, to decrease the amount of phytosanitary products applied, and, as a consequence, to obtain a more ecologically sustainable and healthy wine.

The effects of the one-step replica symmetry breaking on the Sherrington-Kirkpatrick spin glass model in the presence of random field with a joint Gaussian probability density function for the exchange interactions and random fields

NASA Astrophysics Data System (ADS)

Hadjiagapiou, Ioannis A.; Velonakis, Ioannis N.

2018-07-01

The Sherrington-Kirkpatrick Ising spin glass model, in the presence of a random magnetic field, is investigated within the framework of the one-step replica symmetry breaking. The two random variables (exchange integral interaction Jij and random magnetic field hi) are drawn from a joint Gaussian probability density function characterized by a correlation coefficient ρ, assuming positive and negative values. The thermodynamic properties, the three different phase diagrams and system's parameters are computed with respect to the natural parameters of the joint Gaussian probability density function at non-zero and zero temperatures. The low temperature negative entropy controversy, a result of the replica symmetry approach, has been partly remedied in the current study, leading to a less negative result. In addition, the present system possesses two successive spin glass phase transitions with characteristic temperatures.

Harnessing the medical humanities for experiential learning.

PubMed

Singh, Satendra; Barua, Purnima; Dhaliwal, Upreet; Singh, Navjeevan

2017-01-01

A month-long workshop on medical humanities was held in the Jorhat Medical College, Assam in September 2015. It employed experiential learning (both online and onsite) using humanities tools, such as the theatre of the oppressed, art, literature, reflective narratives, movies, the history of medicine, graphic medicine, poetry and diversity studies. As a result of the interactions, 28 volunteer participants, comprising students and faculty members, wrote reflective narratives on doctor​-patient relationships, produced a newsletter and a logo for their medical humanities group, and staged cultural performances and forum theatre. The narratives, participants' reflections and feedback received were subjected to qualitative analysis; the workshop was evaluated using Kirkpatrick's model. The participants learned to examine their attitudes and behaviour, communicate with their bodies, and experience respect for diversity. There was an improvement in their understanding of empathy, ethics and professionalism. The workshop achieved level-3 (behaviour) on Kirkpatrick's model, suggesting that such workshops can initiate a change in the ABCDE attributes (attitude, behaviour, communication, diversity, ethics and empathy) of medical professionals.

Design and fabrication of x-ray Kirkpatrick-Baez microscope for ICF

NASA Astrophysics Data System (ADS)

Mu, Baozhong; Wang, Zhanshan; Huang, Shengling; Yi, Shengzhen; Shen, Zhengxiang

2007-12-01

A hard x-ray (8 keV, Kα line of Cu) Kirkpatrick-Baez (KB) microscope was designed for the diagnostics of inertial confinement fusion (ICF). Three main parts including optical design, fabrication of multilayers, and alignment method were discussed in this paper. According to the deduced equation of aberration in whole field, an optical system was designed, which gives attention to not only spatial resolution but also the collection efficiency. Tungsten (W) and boron carbide (B4C) were chosen as multilayer materials and the non-periodic multilayer with 40 layers was deposited. The measured reflectivity by XRD is better than 18% in the bandwidth range of about 0.3%. Super accurately alignment is another difficulty in the application of KB microscope. To meet the requirements of pointing and co-focusing, a binocular laser pointer which is flexible enough was designed. Finally, an 8keV x-ray tube was used as source in x-ray imaging experiment and images with magnification of 2× were obtained.

Extremal optimization for Sherrington-Kirkpatrick spin glasses

NASA Astrophysics Data System (ADS)

Boettcher, S.

2005-08-01

Extremal Optimization (EO), a new local search heuristic, is used to approximate ground states of the mean-field spin glass model introduced by Sherrington and Kirkpatrick. The implementation extends the applicability of EO to systems with highly connected variables. Approximate ground states of sufficient accuracy and with statistical significance are obtained for systems with more than N=1000 variables using ±J bonds. The data reproduces the well-known Parisi solution for the average ground state energy of the model to about 0.01%, providing a high degree of confidence in the heuristic. The results support to less than 1% accuracy rational values of ω=2/3 for the finite-size correction exponent, and of ρ=3/4 for the fluctuation exponent of the ground state energies, neither one of which has been obtained analytically yet. The probability density function for ground state energies is highly skewed and identical within numerical error to the one found for Gaussian bonds. But comparison with infinite-range models of finite connectivity shows that the skewness is connectivity-dependent.

Measuring perceived effects of drinking an extract of basidiomycetes Agaricus blazei murill: a survey of Japanese consumers with cancer

PubMed Central

Talcott, James A; Clark, Jack A; Lee, Insu P

2007-01-01

Background To survey cancer patients who consume an extract of the Basidiomycetes Agaricus blazei Murill mushroom (Sen-Sei-Ro) to measure their self-assessment of its effects and to develop an instrument for use in future randomized trials. Methods We designed, translated and mailed a survey to 2,346 Japanese consumers of Sen-Sei-Ro self-designated as cancer patients. The survey assessed consumer demographics, cancer history, Sen-Sei-Ro consumption, and its perceived effects. We performed exploratory psychometric analyses to identify distinct, multi-item scales that could summarize perceptions of effects. Results We received completed questionnaires from 782 (33%) of the sampled Sen-Sei-Ro consumers with a cancer history. Respondents represented a broad range of cancer patients familiar with Sen-Sei-Ro. Nearly all had begun consumption after their cancer diagnosis. These consumers expressed consistently positive views, though not extremely so, with more benefit reported for more abstract benefits such as emotional and physical well-being than relief of specific symptoms. We identified two conceptually and empirically distinct and internally consistent summary scales measuring Sen-Sei-Ro consumers' perceptions of its effects, Relief of Symptoms and Functional Well-being (Cronbach's alpha: Relief of Symptoms, α = .74; Functional Well-Being, α = .91). Conclusion Respondents to our survey of Sen-Sei-Ro consumers with cancer reported favorable perceived effects from its use. Our instrument, when further validated, may be a useful outcome in trials assessing this and other complementary and alternative medicine (CAM) substances in cancer patients. PMID:17967191

Further Simplification of the Simple Erosion Narrowing Score With Item Response Theory Methodology.

PubMed

Oude Voshaar, Martijn A H; Schenk, Olga; Ten Klooster, Peter M; Vonkeman, Harald E; Bernelot Moens, Hein J; Boers, Maarten; van de Laar, Mart A F J

2016-08-01

To further simplify the simple erosion narrowing score (SENS) by removing scored areas that contribute the least to its measurement precision according to analysis based on item response theory (IRT) and to compare the measurement performance of the simplified version to the original. Baseline and 18-month data of the Combinatietherapie Bij Reumatoide Artritis (COBRA) trial were modeled using longitudinal IRT methodology. Measurement precision was evaluated across different levels of structural damage. SENS was further simplified by omitting the least reliably scored areas. Discriminant validity of SENS and its simplification were studied by comparing their ability to differentiate between the COBRA and sulfasalazine arms. Responsiveness was studied by comparing standardized change scores between versions. SENS data showed good fit to the IRT model. Carpal and feet joints contributed the least statistical information to both erosion and joint space narrowing scores. Omitting the joints of the foot reduced measurement precision for the erosion score in cases with below-average levels of structural damage (relative efficiency compared with the original version ranged 35-59%). Omitting the carpal joints had minimal effect on precision (relative efficiency range 77-88%). Responsiveness of a simplified SENS without carpal joints closely approximated the original version (i.e., all Δ standardized change scores were ≤0.06). Discriminant validity was also similar between versions for both the erosion score (relative efficiency = 97%) and the SENS total score (relative efficiency = 84%). Our results show that the carpal joints may be omitted from the SENS without notable repercussion for its measurement performance. © 2016, American College of Rheumatology.

Performance of an Early Infant Diagnostic Test, AmpliSens DNA-HIV-FRT, Using Dried Blood Spots Collected from Children Born to Human Immunodeficiency Virus-Infected Mothers in Ukraine.

PubMed

Chang, Joy; Tarasova, Tetyana; Shanmugam, Vedapuri; Azarskova, Marianna; Nguyen, Shon; Hurlston, Mackenzie; Sabatier, Jennifer; Zhang, Guoqing; Osmanov, Saladin; Ellenberger, Dennis; Yang, Chunfu; Vitek, Charles; Liulchuk, Maria; Nizova, Natalya

2015-12-01

An accurate accessible test for early infant diagnosis (EID) is crucial for identifying HIV-infected infants and linking them to treatment. To improve EID services in Ukraine, dried blood spot (DBS) samples obtained from 237 HIV-exposed children (≤18 months of age) in six regions in Ukraine in 2012 to 2013 were tested with the AmpliSens DNA-HIV-FRT assay, the Roche COBAS AmpliPrep/COBAS TaqMan (CAP/CTM) HIV-1 Qual test, and the Abbott RealTime HIV-1 Qualitative assay. In comparison with the paired whole-blood results generated from AmpliSens testing at the oblast HIV reference laboratories in Ukraine, the sensitivity was 0.99 (95% confidence interval [CI], 0.95 to 1.00) for the AmpliSens and Roche CAP/CTM Qual assays and 0.96 (95% CI, 0.90 to 0.98) for the Abbott Qualitative assay. The specificity was 1.00 (95% CI, 0.97 to 1.00) for the AmpliSens and Abbott Qualitative assays and 0.99 (95% CI, 0.96 to 1.00) for the Roche CAP/CTM Qual assay. McNemar analysis indicated that the proportions of positive results for the tests were not significantly different (P > 0.05). Cohen's kappa (0.97 to 0.99) indicated almost perfect agreement among the three tests. These results indicated that the AmpliSens DBS and whole-blood tests performed equally well and were comparable to the two commercially available EID tests. More importantly, the performance characteristics of the AmpliSens DBS test meets the World Health Organization EID test requirements; implementing AmpliSens DBS testing might improve EID services in resource-limited settings. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Presidential Citation for Science and Society

NASA Astrophysics Data System (ADS)

2012-07-01

AGU presented its Presidential Citation for Science and Society to three recipients at a reception on 1 May 2012 in the Rayburn House Office Building as part of the inaugural AGU Science Policy Conference. Google Earth, Jane Lubchenco, who is the under secretary of Commerce for oceans and atmosphere and administrator of the National Oceanic and Atmospheric Administration, and Sen. Olympia Snowe (R-Maine) were recognized for their leadership and vision in shaping policy and heightening public awareness of the value of Earth and space science. “This is an important award because with it AGU brings to light the importance of cutting-edge use-inspired science that helps people, communities, and businesses adapt to climate change and sustainably manage our oceans and coasts,” Lubchenco said.

Experimental determination of J-Q in the two-parameter characterization of fracture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, S.; Chiang, F.P.

1995-11-01

It is well recognized that using a single parameter to characterize crack tip deformation is no long adequate if constraint is present. Several approaches of two-parameter characterization scheme have been proposed. There are the J-T approach, the J-Q approach of Shih et al and the J-Q approach of Sharma and Aravas. The authors propose a scheme to measure the J and Q of the J-Q theory of Sharma and Aravas. They find that with the addition of Q term the experimentally measured U-field displacement component agrees well with the theoretical prediction. The agreement increases as the crack tip constraint increases.more » The results of a SEN and a CN specimen are presented.« less

Building a Virtual Cultural Intelligence Community

DTIC Science & Technology

2007-06-01

within individual cultures. Amartya Sen provides some insight here when he states that “. . . culture is not a homogeneous attribute – there can be...The Wisdom of Crowds (New York:, Anchor Books, 2004), 173-191. 28 Amartya Sen , Identity and Violence: The Illusion of Destiny (New York: W.W. Norton...74 Sen , Amartya . (2006) Identity and violence: The illusion of destiny. New York, NY: W.W. Norton & Co. Simons, Anna. (2006) “Improving human

Arms Industries: New Suppliers and Regional Security

DTIC Science & Technology

1990-01-01

Implication," Asian Defense Journal (Septem- ber 1981), p. 36. 174 Sanders . As quoted: Amartya Sen , "How Is India Doiltg?" The New York Review of Books...University, through the Institute for National Strategic Studies, hosts about two dozen Sen -vor Fellows who engage in original research on national...building sub- marines under license from the West German Thys- sen Nordseewerke. West Germany also has helped Argentina produce Meko 140 class frigates

America’s Transitional Capacity: War, Systems, and Globalization

DTIC Science & Technology

2013-05-23

alleviate human suffering. Amartya Sen supports the Wilsonian philosophy by pointing out that 44Mead, 131. 45Ibid., 103. 46Mead, 164-7. 19...E. Fiasco: the American Military Adventure in Iraq, 2003 to 2005. Reprint ed. New York, NY: Penguin Books, 2007. Sen , Amartya . Development as...they produced a large naval forces in order to expand trade markets and ensure 47Amartya Sen , Development as Freedom (New York: Anchor Books, 1999

Towards a Capability Approach to Careers: Applying Amartya Sen's Thinking to Career Guidance and Development

ERIC Educational Resources Information Center

Robertson, Peter J.

2015-01-01

Amartya Sen's capability approach characterizes an individual's well-being in terms of what they are able to be, and what they are able to do. This framework for thinking has many commonalities with the core ideas in career guidance. Sen's approach is abstract and not in itself a complete or explanatory theory, but a case can be…

KSC-04PD-1556

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. From left, Sen. John F. Kerry, D- Mass., Sen. Bob Graham, D-Fla., and former astronaut and Sen. John H. Glenn, D-Ohio, receive a briefing from Kennedy Space Center Director James W. Kennedy before a tour of the Orbiter Processing Facility (OPF). In the OPF, the orbiter Discovery is being prepared for flight on the next Space Shuttle mission. The tour follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes Americas commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-04PD-1558

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Sen. Bill Nelson (second from left), D-Fla., former astronaut and Sen. John H. Glenn, D-Ohio, and Sen. John F. Kerry, D-Mass., receive a briefing from NASA Vehicle Manager Stephanie Stilson during a tour of the Orbiter Processing Facility (OPF). They are standing under the orbiter Discovery, which is being prepared for flight on the next Space Shuttle mission. The tour follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes Americas commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-04pd1558

NASA Image and Video Library

2004-07-26

KENNEDY SPACE CENTER, FLA. - Sen. Bill Nelson (second from left), D-Fla., former astronaut and Sen. John H. Glenn, D-Ohio, and Sen. John F. Kerry, D-Mass., receive a briefing from NASA Vehicle Manager Stephanie Stilson during a tour of the Orbiter Processing Facility (OPF). They are standing under the orbiter Discovery, which is being prepared for flight on the next Space Shuttle mission. The tour follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes America’s commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-04pd1556

NASA Image and Video Library

2004-07-26

KENNEDY SPACE CENTER, FLA. - From left, Sen. John F. Kerry, D-Mass., Sen. Bob Graham, D-Fla., and former astronaut and Sen. John H. Glenn, D-Ohio, receive a briefing from Kennedy Space Center Director James W. Kennedy before a tour of the Orbiter Processing Facility (OPF). In the OPF, the orbiter Discovery is being prepared for flight on the next Space Shuttle mission. The tour follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes America’s commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

76 FR 17584 - Approval and Promulgation of Implementation Plans; Oklahoma; Regional Haze State Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-30

..., Springlake Campus, Business Conference Center, Meeting Rooms H and I, 1900 Springlake Drive, Oklahoma City... Campus, Business Conference Center, Meeting Rooms H and I, 1900 Springlake Drive, Oklahoma City, Oklahoma... City Zoo and Kirkpatrick Center. Parking for the [[Page 17585

Gauge Impact with 5 Levels of Data

ERIC Educational Resources Information Center

Guskey, Thomas R.

2016-01-01

Effective professional learning evaluation requires consideration of five critical stages or levels of information. These five levels, which are presented in this article, represent an adaptation of an evaluation model developed by Kirkpatrick (1959, 1998) for judging the value of supervisory training programs in business and industry.…

Asset Allocation to Cover a Region of Piracy

DTIC Science & Technology

2011-09-01

1087-1092. 8. Kirkpatrick, S., Optimization by Simulated Annealing. Science, 1983. 220(4598): p. 671-680. 9. Daskin , M. S., A bibliography for some...... a uniform piracy risk and where some areas are more vulnerable than others. Simulated annealing was used to allocate the patrolling naval assets

The Sensed Presence Questionnaire (SenPQ): initial psychometric validation of a measure of the “Sensed Presence” experience

PubMed Central

Bell, Vaughan

2017-01-01

Background The experience of ‘sensed presence’—a feeling or sense that another entity, individual or being is present despite no clear sensory or perceptual evidence—is known to occur in the general population, appears more frequently in religious or spiritual contexts, and seems to be prominent in certain psychiatric or neurological conditions and may reflect specific functions of social cognition or body-image representation systems in the brain. Previous research has relied on ad-hoc measures of the experience and no specific psychometric scale to measure the experience exists to date. Methods Based on phenomenological description in the literature, we created the 16-item Sensed Presence Questionnaire (SenPQ). We recruited participants from (i) a general population sample, and; (ii) a sample including specific selection for religious affiliation, to complete the SenPQ and additional measures of well-being, schizotypy, social anxiety, social imagery, and spiritual experience. We completed an analysis to test internal reliability, the ability of the SenPQ to distinguish between religious and non-religious participants, and whether the SenPQ was specifically related to positive schizotypical experiences and social imagery. A factor analysis was also conducted to examine underlying latent variables. Results The SenPQ was found to be reliable and valid, with religious participants significantly endorsing more items than non-religious participants, and the scale showing a selective relationship with construct relevant measures. Principal components analysis indicates two potential underlying factors interpreted as reflecting ‘benign’ and ‘malign’ sensed presence experiences. Discussion The SenPQ appears to be a reliable and valid measure of sensed presence experience although further validation in neurological and psychiatric conditions is warranted. PMID:28367379

The DTIC Review. Volume 1, Number 1: Nuclear Proliferation and Deterrence in a Changing Political World

DTIC Science & Technology

1995-08-01

Mathematical Expectation" by David Schmeidler and Peter Wakker, "Expected Utility Hypothesis" by Mark Machina, "Rational Behavior" by Amartya Sen ...other regional adversaries are not secure and, hence, are highly sen - sitive to this form of pressure. The question is whether such threats can be used...Warsaw Pact." Moreover, conventional military capabilities are constantly changing through advances in armor, avionics, sen - sors, munitions. etc

Australian Disaster Research Directory (Including Some Contributions from New Zealand). Provisional--1983.

DTIC Science & Technology

1983-06-01

storm surge, cyclone,fire) * social and physical effects of nuclear attack * volcanic hazards statistics of abnormal sea levels * management of high...strengths and weaknesses of these responses * Impact of environmental change on present and future disaster strategies SOME QUESTIONNAIRE STATISTICS Some of...James Cook Univ Black , Mr R G 99 Sen Lec, Civil Eng, QIT Blackman. Dr D R 86 Sen Lec, Dept Mech Eng, V---ash Blong, Dr Russell 80 Sen Lec, Earth

Exploring the longitudinal association between interventions to support the transition to secondary school and child anxiety.

PubMed

Neal, S; Rice, F; Ng-Knight, T; Riglin, L; Frederickson, N

2016-07-01

School transition at around 11-years of age can be anxiety-provoking for children, particularly those with special educational needs (SEN). The present study adopted a longitudinal design to consider how existing transition strategies, categorized into cognitive, behavioral or systemic approaches, were associated with post-transition anxiety amongst 532 typically developing children and 89 children with SEN. Multiple regression analysis indicated that amongst typically developing pupils, systemic interventions were associated with lower school anxiety but not generalized anxiety, when controlling for prior anxiety. Results for children with SEN differed significantly, as illustrated by a Group × Intervention type interaction. Specifically, systemic strategies were associated with lower school anxiety amongst typically developing children and higher school anxiety amongst children with SEN. These findings highlight strategies that schools may find useful in supporting typically developing children over the transition period, whilst suggesting that children with SEN might need a more personalized approach. Copyright © 2016 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

Empowering children with special educational needs to speak up: experiences of inclusive physical education.

PubMed

Coates, Janine; Vickerman, Philip

2010-01-01

The inclusion of children with special educational needs (SEN) has risen up the political agenda since the return of the Labour Government in 1997. This has seen increasing numbers of children with SEN being educated within mainstream schools. This study examines the perspectives of children with SEN attending both mainstream and special schools in relation to their experiences of physical education (PE). Findings demonstrate that children with SEN in both mainstream and special schools enjoy PE, although issues were raised in mainstream schools regarding bullying and the appropriateness of activities in PE lessons. The findings show how children offered suggestions about how to improve PE and make it more beneficial. The findings identify how children are empowered through consultation, and are aware of their needs and abilities. As such it is evident that schools and those supporting inclusive physical activity for children with SEN must use consultation as a tool for empowering pupils as a means of providing them with choices while gaining a rich insight into their lived experiences of PE.

Late-maturing cooking rice Sensyuraku has excellent properties, equivalent to sake rice, for high-quality sake brewing.

PubMed

Anzawa, Yoshihiko; Satoh, Kenji; Satoh, Yuko; Ohno, Satomi; Watanabe, Tsutomu; Katsumata, Kazuaki; Kume, Kazunori; Watanabe, Ken-Ichi; Mizunuma, Masaki; Hirata, Dai

2014-01-01

Low protein content and sufficient grain rigidity are desired properties for the rice used in high-quality sake brewing such as Daiginjo-shu (polishing ratio of the rice, less than 50%). Two kinds of rice, sake rice (SR) and cooking rice (CR), have been used for sake brewing. Compared with those of SR, analyses of CR for high-quality sake brewing using highly polished rice have been limited. Here we described the original screening of late-maturing CR Sensyuraku (SEN) as rice with low protein content and characterization of its properties for high-quality sake brewing. The protein content of SEN was lower than those of SR Gohyakumangoku (GOM) and CR Yukinosei (YUK), and its grain rigidity was higher than that of GOM. The excellent properties of SEN with respect to both water-adsorption and enzyme digestibility were confirmed using a Rapid Visco Analyzer (RVA). Further, we confirmed a clear taste of sake produced from SEN by sensory evaluation. Thus, SEN has excellent properties, equivalent to those of SR, for high-quality sake brewing.

An Evaluation System for the Online Training Programs in Meteorology and Hydrology

ERIC Educational Resources Information Center

Wang, Yong; Zhi, Xiefei

2009-01-01

This paper studies the current evaluation system for the online training program in meteorology and hydrology. CIPP model that includes context evaluation, input evaluation, process evaluation and product evaluation differs from Kirkpatrick model including reactions evaluation, learning evaluation, transfer evaluation and results evaluation in…

Oracle or Monacle: Research Concerning Attitudes Toward Feminism.

ERIC Educational Resources Information Center

Prescott, Suzanne; Schmid, Margaret

Both popular studies and more serious empirical studies of attitudes toward feminism are reviewed beginning with Clifford Kirkpatrick's early empirical work and including the more recent empirical studies completed since 1970. The review examines the contents of items used to measure feminism, and the methodology and sampling used in studies, as…

A Systematic Literature Review of Faculty Development for Teacher Educators

ERIC Educational Resources Information Center

Phuong, Tam T.; Cole, S. Catherine; Zarestky, Jill

2018-01-01

Although ample literature exists regarding the effectiveness of faculty development (FD) activities, there is a gap in the literature synthesizing its outcomes. This review, using a predetermined review protocol, analyzed 22 publications on FD for teacher educators using Kirkpatrick's training evaluation taxonomy. We found that North American…

Providing Demonstrable Return-on-Investment for Organisational Learning and Training

ERIC Educational Resources Information Center

Elliott, Michael; Dawson, Ray; Edwards, Janet

2009-01-01

Purpose: The aim of this paper is to present a holistic approach to training, that clearly demonstrates cost savings with improved effectiveness and efficiencies that are aligned to business objectives. Design/methodology/approach: Extending Kirkpatrick's evaluation framework with Phillips's return-on-investment (ROI) concepts, the paper conveys a…

Evaluation of Training Programs for Rural Development

ERIC Educational Resources Information Center

Indira, A.

2008-01-01

An Evaluation of the "Impact Assessment of the Training Programs" of a National Level Training Institution in India was conducted using the Kirkpatrick Method (KP Method). The studied Institution takes up research, provides training, offers consultancy and initiates action in the rural sector of India. The evaluation study used a…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saakyan, D.B.

The variant of the Kirkpatrick-Sherrington model generalized by Derrida for the case of arbitrary spin is considered. When the number of simultaneously interacting neighbors tends to infinity, a solution to the model is obtained not only by reduction to the random-energy model but also by means of the replica method with the Parisi ansatz.

Mind Maps as Facilitative Tools in Science Education

ERIC Educational Resources Information Center

Safar, Ammar H.; Jafer,Yaqoub J.; Alqadiri, Mohammad A.

2014-01-01

This study explored the perceptions, attitudes, and willingness of pre-service science teachers in the College of Education at Kuwait University about using concept/mind maps and its related application software as facilitative tools, for teaching and learning, in science education. The first level (i.e., reaction) of Kirkpatrick's/Phillips'…

The intersectionality of postsecondary pathways: the case of high school students with special education needs.

PubMed

Robson, Karen L; Anisef, Paul; Brown, Robert S; Parekh, Gillian

2014-08-01

Using data from the Toronto District School Board, we examine the postsecondary pathways of students with special education needs (SEN). We consider both university and college pathways, employing multilevel multinomial logistic regressions, conceptualizing our findings within a life course and intersectionality framework. Our findings reveal that having SEN reduces the likelihood of confirming university, but increases the likelihood of college confirmation. We examine a set of known determinants of postsecondary education (PSE) pathways that were derived from the literature and employ exploratory statistical interactions to examine if the intersection of various traits differentially impacts upon the PSE trajectories of students with SEN. Our findings reveal that parental education, neighborhood wealth, race, and streaming impact on the postsecondary pathways of students with SEN in Toronto.

2011 NASA Day at the Capitol

NASA Image and Video Library

2011-02-10

Astronaut Steven Swanson (front) speaks to members of the Mississippi Senate in chambers, with Lt. Gov. Phil Bryant presiding (rear), during NASA Day at the Capitol in Jackson on Feb. 10. Swanson was joined at the podium by Sen. David Baria, D-Bay St. Louis (l to r), NASA Shared Services Center Executive Director Rick Arbuthnot, Stennis Director Patrick Scheuermann, Sen. Ezell Lee, D-Picayune, and Sen. Billy Hewes, R-Gulfport. Baria, Lee and Hewes all are members of the Mississippi Senate Gulf Coast delegation.

Eye sensitivity in soft contact lens wearers.

PubMed

Spyridon, Michael; Hickson-Curran, Sheila; Hunt, Chris; Young, Graeme

2012-12-01

To estimate the prevalence of self-reported "sensitive eyes" (SEs) in soft contact lens (CL) wearers, evaluate the clinical characteristics of patients with SEs, and examine the effect of refitting them with silicone hydrogel lenses. After self-assessment, 2154 CL wearers were separated into SE and non-SE patients. Demographics, biometric data, wearing time, symptoms, and signs were compared between the two populations. Sixty-three SE patients were randomized into senofilcon A (senA) lenses and 65 into a non-senA arm (lotrafilcon B, omafilcon A, and balafilcon A lenses). The performance of senA lenses was compared against habitual and non-senA lenses 2 weeks later. A total of 12.2% of CL wearers reported SEs with their habitual CLs. No significant differences were noticed between SE and non-SE patients in sex, age, or refraction. The prevalence of dryness (43 vs 19%, p < 0.0001), irritation (25 vs 11%, p < 0.0001), redness (20 vs 6%, p < 0.0001), and stinging (6 vs 1%, p < 0.0001) was higher in SE patients. Average wearing time (13.0 vs 14.1 hours, p < 0.0001) was lower in this group. Limbal/bulbar hyperemia and corneal/conjunctival staining were not significantly different between the two populations. Senofilcon A increased the number of patients reporting no dryness (habitual vs senA, 20 vs 44%, p < 0.0003), irritation (22 vs 37%, p = 0.015), redness (52 vs 76%, p =0.009) and stinging (58 vs 77%, p = 0.012) but did not significantly affect clinical signs. Senofilcon A was significantly more efficient than non-senA lenses in improving dryness (scale of 0 to 3: senA vs non-senA, 0.64 vs 1.02, p = 0.0056), irritation (0.72 vs 1.16, p = 0.0015), and stinging (0.18 vs 0.53, p = 0.0049). A substantial proportion of CL wearers report SEs with their habitual lenses. These patients are characterized by a high prevalence of additional symptoms, which are not reflected in clinical signs. Senofilcon A, or lenses with similar properties, may help reduce these symptoms in SE patients.

Frustrated Freedom: The Effects of Agency and Wealth on Wellbeing in Rural Mozambique.

PubMed

Victor, Bart; Fischer, Edward; Cooil, Bruce; Vergara, Alfredo; Mukolo, Abraham; Blevins, Meridith

2013-07-01

In Sen's capability view of poverty, wellbeing is threatened by both deficits of wealth and deficits of individual agency. Sen further predicts that "unfreedom," or low levels of agency will suppress the wellbeing effects of higher levels of wealth. The current paper extends Sen's view to include a condition, labeled "frustrated freedom," in which relatively higher levels of agency can heighten the poverty effects of relatively low levels of material wealth. Applying data from a large scale population study of female heads of household in rural Mozambique, the paper empirically tests Sen's view and the proposed extension. As predicted, agency is found to moderate the relationship between agency, wealth, and wellbeing, uncovering evidence of both unfreedom and frustrated freedom in the population. Further research into the complex dynamics of wellbeing and poverty are called for by the authors.

Senator Jake Garn on the KC-135

NASA Technical Reports Server (NTRS)

1985-01-01

Senator Jake Garn appears to be springing from a trampoline in this scene, taken during a brief period of weightlessness provided by a parabola flown by the KC-135. Jeff Bingham, an aide to the senator, floats freely nearby (25616); Sen. Garn and Jeff Bingham prepare to ease from a partially anchored position to a totally free flying mode during a brief weightless session (25617); Sen. Garn gets an initial 'feel' of weightlessness as his feet float freely while he anchors himself with his hands. Seated nearby is his aide Bingham (25618); Sen. Garn (background) shares some of the ceiling space of the KC-135 with Bingham (25619); Sen. Garn (foreground) takes a seat behind the KC-135's crew in the forward cabin. Roger Zweig and Joseph S. Algranti, pilot and co-pilot, are partially visible in the background (25620).

Testing Students with Special Educational Needs in Large-Scale Assessments – Psychometric Properties of Test Scores and Associations with Test Taking Behavior

PubMed Central

Pohl, Steffi; Südkamp, Anna; Hardt, Katinka; Carstensen, Claus H.; Weinert, Sabine

2016-01-01

Assessing competencies of students with special educational needs in learning (SEN-L) poses a challenge for large-scale assessments (LSAs). For students with SEN-L, the available competence tests may fail to yield test scores of high psychometric quality, which are—at the same time—measurement invariant to test scores of general education students. We investigated whether we can identify a subgroup of students with SEN-L, for which measurement invariant competence measures of adequate psychometric quality may be obtained with tests available in LSAs. We furthermore investigated whether differences in test-taking behavior may explain dissatisfying psychometric properties and measurement non-invariance of test scores within LSAs. We relied on person fit indices and mixture distribution models to identify students with SEN-L for whom test scores with satisfactory psychometric properties and measurement invariance may be obtained. We also captured differences in test-taking behavior related to guessing and missing responses. As a result we identified a subgroup of students with SEN-L for whom competence scores of adequate psychometric quality that are measurement invariant to those of general education students were obtained. Concerning test taking behavior, there was a small number of students who unsystematically picked response options. Removing these students from the sample slightly improved item fit. Furthermore, two different patterns of missing responses were identified that explain to some extent problems in the assessments of students with SEN-L. PMID:26941665

Vibration and acoustic frequency spectra for industrial process modeling using selective fusion multi-condition samples and multi-source features

NASA Astrophysics Data System (ADS)

Tang, Jian; Qiao, Junfei; Wu, ZhiWei; Chai, Tianyou; Zhang, Jian; Yu, Wen

2018-01-01

Frequency spectral data of mechanical vibration and acoustic signals relate to difficult-to-measure production quality and quantity parameters of complex industrial processes. A selective ensemble (SEN) algorithm can be used to build a soft sensor model of these process parameters by fusing valued information selectively from different perspectives. However, a combination of several optimized ensemble sub-models with SEN cannot guarantee the best prediction model. In this study, we use several techniques to construct mechanical vibration and acoustic frequency spectra of a data-driven industrial process parameter model based on selective fusion multi-condition samples and multi-source features. Multi-layer SEN (MLSEN) strategy is used to simulate the domain expert cognitive process. Genetic algorithm and kernel partial least squares are used to construct the inside-layer SEN sub-model based on each mechanical vibration and acoustic frequency spectral feature subset. Branch-and-bound and adaptive weighted fusion algorithms are integrated to select and combine outputs of the inside-layer SEN sub-models. Then, the outside-layer SEN is constructed. Thus, "sub-sampling training examples"-based and "manipulating input features"-based ensemble construction methods are integrated, thereby realizing the selective information fusion process based on multi-condition history samples and multi-source input features. This novel approach is applied to a laboratory-scale ball mill grinding process. A comparison with other methods indicates that the proposed MLSEN approach effectively models mechanical vibration and acoustic signals.

Understanding the conviction of Binayak Sen: Neocolonialism, political violence and the political economy of health in the central Indian tribal belt.

PubMed

Kennedy, Jonathan J; King, Lawrence P

2011-05-01

The health of adivasis' (Scheduled Tribes or indigenous peoples) is far worse than the general Indian population. Binayak Sen, a renowned Indian public health practitioner, has worked with adivasis in central India for over thirty years. On Christmas Eve 2010 Sen was convicted of involvement with Maoist insurgents and sentenced to life in prison. Sen's conviction has been condemned by Amnesty International and Human Rights Watch, and medical journals such as The Lancet and the British Medical Journal are campaigning for his release. This short report addresses the apparently vexing question of how such a miscarriage of justice could happen to a well-reputed physician in a country that is widely referred to as 'the world's largest democracy'. Both Sen's conviction and the health crisis among adivasis in central India are symptoms of what Paul Farmer (2005) refers to as 'deeper pathologies of power'; specifically, the neocolonial political economy in which the state is very active in dispossessing adivasis but inactive in providing benevolent functions. Thus, the case demonstrates the manner in which public health is intimately related to social, economic and political processes. Copyright © 2011 Elsevier Ltd. All rights reserved.

Adaptation of Kirkpatrick's Four Level Model of Training Criteria to Assessment of Learning Outcomes and Program Evaluation in Higher Education

ERIC Educational Resources Information Center

Praslova, Ludmila

2010-01-01

Assessment of educational effectiveness provides vitally important feedback to Institutions of Higher Education. It also provides important information to external stakeholders, such as prospective students, parents, governmental and local regulatory entities, professional and regional accrediting organizations, and representatives of the…

An Attachment Theory Approach to Narrating the Faith Journey of Children of Parental Divorce

ERIC Educational Resources Information Center

Kiesling, Chris

2011-01-01

This study explores the effects of parental divorce on a child's faith. Drawing from attachment theory, Granqvist and Kirkpatrick proposed two probable developmental pathways to religion. For those with secure attachment, whose cumulative experiences of sensitive, religious caregivers enhance the development of a God image as loving; belief…

Evaluating an Organizational Protocol to Implement Effective Leadership Meetings

ERIC Educational Resources Information Center

Anderson, Erika

2009-01-01

The problem on which this study focused was the need to organize and implement effective leadership meetings that led to improved professional collaboration. The purpose was to evaluate the use of a protocol in organizing and implementing such meetings. The research questions were framed around the four levels of the Kirkpatrick (1996) evaluation…

Evaluation of Cross-Cultural Training Programs for International Students from East Europe

ERIC Educational Resources Information Center

Kovacova, Michaela; Eckert, Stefan

2010-01-01

This paper presents a comparative evaluation of didactic and experiential training in Germany carried out on a sample of international university students from Eastern Europe. The long-term evaluation was conducted by using a quasi-experimental design with a control group according to Kirkpatrick's model including three steps: reaction, learning…

PLASMA PROTEIN PROFILING AS A HIGH THROUGHPUT TOOL FOR CHEMICAL SCREENING USING A SMALL FISH MODEL

EPA Science Inventory

Hudson, R. Tod, Michael J. Hemmer, Kimberly A. Salinas, Sherry S. Wilkinson, James Watts, James T. Winstead, Peggy S. Harris, Amy Kirkpatrick and Calvin C. Walker. In press. Plasma Protein Profiling as a High Throughput Tool for Chemical Screening Using a Small Fish Model (Abstra...

Variable Magnification With Kirkpatrick-Baez Optics for Synchrotron X-Ray Microscopy

PubMed Central

Jach, Terrence; Bakulin, Alex S.; Durbin, Stephen M.; Pedulla, Joseph; Macrander, Albert

2006-01-01

We describe the distinction between the operation of a short focal length x-ray microscope forming a real image with a laboratory source (convergent illumination) and with a highly collimated intense beam from a synchrotron light source (Köhler illumination). We demonstrate the distinction with a Kirkpatrick-Baez microscope consisting of short focal length multilayer mirrors operating at an energy of 8 keV. In addition to realizing improvements in the resolution of the optics, the synchrotron radiation microscope is not limited to the usual single magnification at a fixed image plane. Higher magnification images are produced by projection in the limit of geometrical optics with a collimated beam. However, in distinction to the common method of placing the sample behind the optical source of a diverging beam, we describe the situation in which the sample is located in the collimated beam before the optical element. The ultimate limits of this magnification result from diffraction by the specimen and are determined by the sample position relative to the focal point of the optic. We present criteria by which the diffraction is minimized. PMID:27274930

Quantum Optimization of Fully Connected Spin Glasses

NASA Astrophysics Data System (ADS)

Venturelli, Davide; Mandrà, Salvatore; Knysh, Sergey; O'Gorman, Bryan; Biswas, Rupak; Smelyanskiy, Vadim

2015-07-01

Many NP-hard problems can be seen as the task of finding a ground state of a disordered highly connected Ising spin glass. If solutions are sought by means of quantum annealing, it is often necessary to represent those graphs in the annealer's hardware by means of the graph-minor embedding technique, generating a final Hamiltonian consisting of coupled chains of ferromagnetically bound spins, whose binding energy is a free parameter. In order to investigate the effect of embedding on problems of interest, the fully connected Sherrington-Kirkpatrick model with random ±1 couplings is programmed on the D-Wave TwoTM annealer using up to 270 qubits interacting on a Chimera-type graph. We present the best embedding prescriptions for encoding the Sherrington-Kirkpatrick problem in the Chimera graph. The results indicate that the optimal choice of embedding parameters could be associated with the emergence of the spin-glass phase of the embedded problem, whose presence was previously uncertain. This optimal parameter setting allows the performance of the quantum annealer to compete with (and potentially outperform, in the absence of analog control errors) optimized simulated annealing algorithms.

Eight-channel Kirkpatrick-Baez microscope for multiframe x-ray imaging diagnostics in laser plasma experiments.

PubMed

Yi, Shengzhen; Zhang, Zhe; Huang, Qiushi; Zhang, Zhong; Mu, Baozhong; Wang, Zhanshan; Fang, Zhiheng; Wang, Wei; Fu, Sizu

2016-10-01

Because grazing-incidence Kirkpatrick-Baez (KB) microscopes have better resolution and collection efficiency than pinhole cameras, they have been widely used for x-ray imaging diagnostics of laser inertial confinement fusion. The assembly and adjustment of a multichannel KB microscope must meet stringent requirements for image resolution and reproducible alignment. In the present study, an eight-channel KB microscope was developed for diagnostics by imaging self-emission x-rays with a framing camera at the Shenguang-II Update (SGII-Update) laser facility. A consistent object field of view is ensured in the eight channels using an assembly method based on conical reference cones, which also allow the intervals between the eight images to be tuned to couple with the microstrips of the x-ray framing camera. The eight-channel KB microscope was adjusted via real-time x-ray imaging experiments in the laboratory. This paper describes the details of the eight-channel KB microscope, its optical and multilayer design, the assembly and alignment methods, and results of imaging in the laboratory and at the SGII-Update.

Many-body localization-delocalization transition in the quantum Sherrington-Kirkpatrick model

NASA Astrophysics Data System (ADS)

Mukherjee, Sudip; Nag, Sabyasachi; Garg, Arti

2018-04-01

We analyze the many-body localization- (MBL) to-delocalization transition in the Sherrington-Kirkpatrick (SK) model of Ising spin glass in the presence of a transverse field Γ . Based on energy-resolved analysis, which is of relevance for a closed quantum system, we show that the quantum SK model has many-body mobility edges separating the MBL phase, which is nonergodic and nonthermal, from the delocalized phase, which is ergodic and thermal. The range of the delocalized regime increases with an increase in the strength of Γ , and eventually for Γ larger than ΓCP the entire many-body spectrum is delocalized. We show that the Renyi entropy is almost independent of the system size in the MBL phase while the delocalized phase shows extensive Renyi entropy. We further obtain the spin-glass transition curve in the energy density ɛ -Γ plane from the collapse of the eigenstate spin susceptibility. We demonstrate that in most of the parameter regime, the spin-glass transition occurs close to the MBL transition, indicating that the spin-glass phase is nonergodic and nonthermal while the paramagnetic phase is delocalized and thermal.

Development of scanning x-ray fluorescence microscope with spatial resolution of 30 nm using Kirkpatrick-Baez mirror optics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matsuyama, S.; Mimura, H.; Yumoto, H.

We developed a high-spatial-resolution scanning x-ray fluorescence microscope (SXFM) using Kirkpatrick-Baez mirrors. As a result of two-dimensional focusing tests at BL29XUL of SPring-8, the full width at half maximum of the focused beam was achieved to be 50x30 nm{sup 2} (VxH) under the best focusing conditions. The measured beam profiles were in good agreement with simulated results. Moreover, beam size was controllable within the wide range of 30-1400 nm by changing the virtual source size, although photon flux and size were in a trade-off relationship. To demonstrate SXFM performance, a fine test chart fabricated using focused ion beam system wasmore » observed to determine the best spatial resolution. The element distribution inside a logo mark of SPring-8 in the test chart, which has a minimum linewidth of approximately 50-60 nm, was visualized with a spatial resolution better than 30 nm using the smallest focused x-ray beam.« less

HYBRID Simulations of Diffraction-Limited Focusing with Kirkpatrick-Baez Mirrors for a Next-Generation In Situ Hard X-ray Nanoprobe

NASA Astrophysics Data System (ADS)

Maser, Jörg; Shi, Xianbo; Reininger, Ruben; Lai, Barry; Vogt, Stefan

2016-12-01

Next-generation hard X-ray nanoprobe beamlines such as the In Situ Nanoprobe (ISN) beamline being planned at the Advanced Photon Source aim at providing very high spatial resolution while also enabling very high focused flux, to study complex materials and devices using fast, multidimensional imaging across many length scales. The ISN will use diffractive optics to focus X-rays with a bandpass of Δ E/ E = 10-4 into a focal spot of 20 nm or below. Reflective optics in Kirkpatrick-Baez geometry will be used to focus X-rays with a bandpass as large as Δ E/ E = 10-2 into a focal spot of 50 nm. Diffraction-limited focusing with reflective optics is achieved by spatial filtering and use of a very long, vertically focusing mirror. To quantify the performance of the ISN beamline, we have simulated the propagation of both partially and fully coherent wavefronts from the undulator source, through the ISN beamline and into the mirror-based focal spot. Simulations were carried out using the recently developed software " HYBRID."

VizieR Online Data Catalog: Brown dwarf surface gravities with Keck/NIRSPEC (Martin , 2017)

NASA Astrophysics Data System (ADS)

Martin, E. C.; Mace, G. N.; McLean, I. S.; Logsdon, S. E.; Rice, E. L.; Kirkpatrick, J. D.; Burgasser, A. J.; McGovern, M. R.; Prato, L.

2017-10-01

In this paper, we follow up on prior NIR spectroscopy by our group and use a modified Allers & Liu (A13, 2013ApJ...772...79A) method to determine surface gravities for 228 M, L, and T dwarfs. We present medium-resolution (R~20000) J-band spectra of 85 M dwarfs, 92 L dwarfs, and 51 T dwarfs obtained as part of the Keck NIRSPEC Brown Dwarf Spectroscopic Survey (BDSS). Ninety-seven spectra were published previously in McLean+ (2003ApJ...596..561M), Burgasser+ (2003ApJ...592.1186B), McGovern+ (2004ApJ...600.1020M), Rice+ (2010ApJS..186...63R), Kirkpatrick+ (2010, J/ApJS/190/100), Luhman (2012ARA&A..50...65L), Thompson+ (2013PASP..125..809T), Mace+ (2013, J/ApJS/205/6), Mace+ (2013ApJ...777...36M), and Kirkpatrick+ (2014, J/ApJ/783/122), and the remaining 131 are presented here for the first time. Observation information (spanning 1999 Apr to 2015 Mar) for all of the targets in our sample is listed in Table 1. (4 data files).

NASA Day at the Capitol

NASA Image and Video Library

2009-02-19

Stennis Space Center leaders and guests visit with Mississippi Senate members in chambers during NASA Day at the Capitol events in Jackson on Feb. 19. Standing at the Senate podium (rear) is Mississippi Lt. Gov. Phil Bryant. Standing at the lectern below are (l to r): Sen. David Baria, D-Bay St. Louis; Partners for Stennis Chair Clay Wagner; NASA Shared Services Center Director Rick Arbuthnot; astronaut Rex Walheim; Stennis Space Center Director Gene Goldman; President Pro Tempore Billy Hewes, R-Gulfport; Sen. Ezell Lee, D-Picayune; and Sen. Tommy Gollott, R-Biloxi.

Use of a novel extended blink test to evaluate the performance of two polyvinylpyrrolidone-containing, silicone hydrogel contact lenses

PubMed Central

Schafer, Jeffery; Reindel, William; Steffen, Robert; Mosehauer, Gary; Chinn, Joseph

2018-01-01

Background Sustained digital display viewing reduces eye blink frequency and tear film stability. To retain water and preserve a smooth optical surface, contact lens manufacturers have integrated the humectant polyvinylpyrrolidone (PVP) into silicone hydrogel contact lenses. In this study, extended blink time (EBT) was used to assess visual stability over a prolonged blink interval of two PVP-containing silicone hydrogel lenses, samfilcon A (SAM) and senofilcon A (SEN). Materials and methods This randomized, bilateral, masked, crossover study assessed lens performance in ten subjects after 16 hours of wear. EBT, ie, the time elapsed between cessation of blinking and blur-out of a threshold letter on the acuity chart, was measured. At the end of the wear period, subjects reported duration of computer use and rated visual quality (VQ) and comfort while wearing the assigned lens, and the investigator evaluated lens surface wetting characteristics. Each lens was removed and immediately weighed to determine total water content. Results EBTs were 10.42 seconds for SAM and 8.04 seconds for SEN (p = 0.015). Subjective ratings of VQ after 16 hours of wear were 84.6 for SAM and 74.4 for SEN (p = 0.049). Comfort ratings were 85.9 for SAM and 80.2 for SEN (p > 0.05). Median times of computer use were 6–8 hours for both lens types. Post blink, 70.0% of SAM and 30.0% of SEN lenses were completely wet (p = 0.021). Total water content after wear was 43.7% for SAM and 35.5% for SEN (p < 0.001). Conclusion EBT measurement indicated more stable vision with the PVP-containing SAM polymer compared with the PVP-containing SEN polymer. The SAM polymer also demonstrated better surface wetting and maintained higher water content after a prolonged period of wear. EBT can be valuable in assessing vision stability of patients after hours of computer use. PMID:29765195

A quasi-exclusive European ancestry in the Senepol tropical cattle breed highlights the importance of the slick locus in tropical adaptation.

PubMed

Flori, Laurence; Gonzatti, Mary Isabel; Thevenon, Sophie; Chantal, Isabelle; Pinto, Joar; Berthier, David; Aso, Pedro M; Gautier, Mathieu

2012-01-01

The Senepol cattle breed (SEN) was created in the early XX(th) century from a presumed cross between a European (EUT) breed (Red Poll) and a West African taurine (AFT) breed (N'Dama). Well adapted to tropical conditions, it is also believed trypanotolerant according to its putative AFT ancestry. However, such origins needed to be verified to define relevant husbandry practices and the genetic background underlying such adaptation needed to be characterized. We genotyped 153 SEN individuals on 47,365 SNPs and combined the resulting data with those available on 18 other populations representative of EUT, AFT and Zebu (ZEB) cattle. We found on average 89% EUT, 10.4% ZEB and 0.6% AFT ancestries in the SEN genome. We further looked for footprints of recent selection using standard tests based on the extent of haplotype homozygosity. We underlined i) three footprints on chromosome (BTA) 01, two of which are within or close to the polled locus underlying the absence of horns and ii) one footprint on BTA20 within the slick hair coat locus, involved in thermotolerance. Annotation of these regions allowed us to propose three candidate genes to explain the observed signals (TIAM1, GRIK1 and RAI14). Our results do not support the accepted concept about the AFT origin of SEN breed. Initial AFT ancestry (if any) might have been counter-selected in early generations due to breeding objectives oriented in particular toward meat production and hornless phenotype. Therefore, SEN animals are likely susceptible to African trypanosomes which questions the importation of SEN within the West African tsetse belt, as promoted by some breeding societies. Besides, our results revealed that SEN breed is predominantly a EUT breed well adapted to tropical conditions and confirmed the importance in thermotolerance of the slick locus.

A Quasi-Exclusive European Ancestry in the Senepol Tropical Cattle Breed Highlights the Importance of the slick Locus in Tropical Adaptation

PubMed Central

Flori, Laurence; Gonzatti, Mary Isabel; Thevenon, Sophie; Chantal, Isabelle; Pinto, Joar; Berthier, David; Aso, Pedro M.; Gautier, Mathieu

2012-01-01

Background The Senepol cattle breed (SEN) was created in the early XXth century from a presumed cross between a European (EUT) breed (Red Poll) and a West African taurine (AFT) breed (N’Dama). Well adapted to tropical conditions, it is also believed trypanotolerant according to its putative AFT ancestry. However, such origins needed to be verified to define relevant husbandry practices and the genetic background underlying such adaptation needed to be characterized. Methodology/Principal Findings We genotyped 153 SEN individuals on 47,365 SNPs and combined the resulting data with those available on 18 other populations representative of EUT, AFT and Zebu (ZEB) cattle. We found on average 89% EUT, 10.4% ZEB and 0.6% AFT ancestries in the SEN genome. We further looked for footprints of recent selection using standard tests based on the extent of haplotype homozygosity. We underlined i) three footprints on chromosome (BTA) 01, two of which are within or close to the polled locus underlying the absence of horns and ii) one footprint on BTA20 within the slick hair coat locus, involved in thermotolerance. Annotation of these regions allowed us to propose three candidate genes to explain the observed signals (TIAM1, GRIK1 and RAI14). Conclusions/Significance Our results do not support the accepted concept about the AFT origin of SEN breed. Initial AFT ancestry (if any) might have been counter-selected in early generations due to breeding objectives oriented in particular toward meat production and hornless phenotype. Therefore, SEN animals are likely susceptible to African trypanosomes which questions the importation of SEN within the West African tsetse belt, as promoted by some breeding societies. Besides, our results revealed that SEN breed is predominantly a EUT breed well adapted to tropical conditions and confirmed the importance in thermotolerance of the slick locus. PMID:22675421

A Study on the Nonmetallic Inclusion Motions in a Swirling Flow Submerged Entry Nozzle in a New Cylindrical Tundish Design

NASA Astrophysics Data System (ADS)

Ni, Peiyuan; Ersson, Mikael; Jonsson, Lage Tord Ingemar; Jönsson, Pär Göran

2018-04-01

Different sizes and shapes of nonmetallic inclusions in a swirling flow submerged entry nozzle (SEN) placed in a new tundish design were investigated by using a Lagrangian particle tracking scheme. The results show that inclusions in the current cylindrical tundish have difficulties remaining in the top tundish region, since a strong rotational steel flow exists in this region. This high rotational flow of 0.7 m/s provides the required momentum for the formation of a strong swirling flow inside the SEN. The results show that inclusions larger than 40 µm were found to deposit to a smaller extent on the SEN wall compared to smaller inclusions. The reason is that these large inclusions have Separation number values larger than 1. Thus, the swirling flow causes these large size inclusions to move toward the SEN center. For the nonspherical inclusions, large size inclusions were found to be deposited on the SEN wall to a larger extent, compared to spherical inclusions. More specifically, the difference of the deposited inclusion number is around 27 pct. Overall, it was found that the swirling flow contains three regions, namely, the isotropic core region, the anisotropic turbulence region and the near-wall region. Therefore, anisotropic turbulent fluctuations should be taken into account when the inclusion motion was tracked in this complex flow. In addition, many inclusions were found to deposit at the SEN inlet region. The plotted velocity distribution shows that the inlet flow is very chaotic. A high turbulent kinetic energy value of around 0.08 m2/s2 exists in this region, and a recirculating flow was also found here. These flow characteristics are harmful since they increase the inclusion transport toward the wall. Therefore, a new design of the SEN inlet should be developed in the future, with the aim to modify the inlet flow so that the inclusion deposition is reduced.

Graphite nanoplatelet enabled embeddable fiber sensor for in situ curing monitoring and structural health monitoring of polymeric composites.

PubMed

Luo, Sida; Liu, Tao

2014-06-25

A graphite nanoplatelet (GNP) thin film enabled 1D fiber sensor (GNP-FibSen) was fabricated by a continuous roll-to-roll spray coating process, characterized by scanning electron microscopy and Raman spectroscopy and evaluated by coupled electrical-mechanical tensile testing. The neat GNP-FibSen sensor shows very high gauge sensitivity with a gauge factor of ∼17. By embedding the sensor in fiberglass prepreg laminate parts, the dual functionalities of the GNP-FibSen sensor were demonstrated. In the manufacturing process, the resistance change of the embedded sensor provides valuable local resin curing information. After the manufacturing process, the same sensor is able to map the strain/stress states and detect the failure of the host composite. The superior durability of the embedded GNP-FibSen sensor has been demonstrated through 10,000 cycles of coupled electromechanical tests.

Frustrated Freedom: The Effects of Agency and Wealth on Wellbeing in Rural Mozambique

PubMed Central

Victor, Bart; Fischer, Edward; Cooil, Bruce; Vergara, Alfredo; Mukolo, Abraham; Blevins, Meridith

2014-01-01

In Sen's capability view of poverty, wellbeing is threatened by both deficits of wealth and deficits of individual agency. Sen further predicts that “unfreedom,” or low levels of agency will suppress the wellbeing effects of higher levels of wealth. The current paper extends Sen's view to include a condition, labeled “frustrated freedom,” in which relatively higher levels of agency can heighten the poverty effects of relatively low levels of material wealth. Applying data from a large scale population study of female heads of household in rural Mozambique, the paper empirically tests Sen's view and the proposed extension. As predicted, agency is found to moderate the relationship between agency, wealth, and wellbeing, uncovering evidence of both unfreedom and frustrated freedom in the population. Further research into the complex dynamics of wellbeing and poverty are called for by the authors. PMID:25125791

miR-Sens--a retroviral dual-luciferase reporter to detect microRNA activity in primary cells.

PubMed

Beillard, Emmanuel; Ong, Siau Chi; Giannakakis, Antonis; Guccione, Ernesto; Vardy, Leah A; Voorhoeve, P Mathijs

2012-05-01

MicroRNA-mRNA interactions are commonly validated and deconstructed in cell lines transfected with luciferase reporters. However, due to cell type-specific variations in microRNA or RNA-binding protein abundance, such assays may not reliably reflect microRNA activity in other cell types that are less easily transfected. In order to measure miRNA activity in primary cells, we constructed miR-Sens, a MSCV-based retroviral vector that encodes both a Renilla luciferase reporter gene controlled by microRNA binding sites in its 3' UTR and a Firefly luciferase normalization gene. miR-Sens sensors can be efficiently transduced in primary cells such as human fibroblasts and mammary epithelial cells, and allow the detection of overexpressed and, more importantly, endogenous microRNAs. Notably, we find that the relative luciferase activity is correlated to the miRNA expression, allowing quantitative measurement of microRNA activity. We have subsequently validated the miR-Sens 3' UTR vectors with known human miRNA-372, miRNA-373, and miRNA-31 targets (LATS2 and TXNIP). Overall, we observe that miR-Sens-based assays are highly reproducible, allowing detection of the independent contribution of multiple microRNAs to 3' UTR-mediated translational control of LATS2. In conclusion, miR-Sens is a new tool for the efficient study of microRNA activity in primary cells or panels of cell lines. This vector will not only be useful for studies on microRNA biology, but also more broadly on other factors influencing the translation of mRNAs.

Transferability and within- and between-laboratory reproducibilities of EpiSensA for predicting skin sensitization potential in vitro: A ring study in three laboratories.

PubMed

Mizumachi, Hideyuki; Sakuma, Megumi; Ikezumi, Mayu; Saito, Kazutoshi; Takeyoshi, Midori; Imai, Noriyasu; Okutomi, Hiroko; Umetsu, Asami; Motohashi, Hiroko; Watanabe, Mika; Miyazawa, Masaaki

2018-05-03

The epidermal sensitization assay (EpiSensA) is an in vitro skin sensitization test method based on gene expression of four markers related to the induction of skin sensitization; the assay uses commercially available reconstructed human epidermis. EpiSensA has exhibited an accuracy of 90% for 72 chemicals, including lipophilic chemicals and pre-/pro-haptens, when compared with the results of the murine local lymph node assay. In this work, a ring study was performed by one lead and two naive laboratories to evaluate the transferability, as well as within- and between-laboratory reproducibilities, of EpiSensA. Three non-coded chemicals (two lipophilic sensitizers and one non-sensitizer) were tested for the assessment of transferability and 10 coded chemicals (seven sensitizers and three non-sensitizers, including four lipophilic chemicals) were tested for the assessment of reproducibility. In the transferability phase, the non-coded chemicals (two sensitizers and one non-sensitizer) were correctly classified at the two naive laboratories, indicating that the EpiSensA protocol was transferred successfully. For the within-laboratory reproducibility, the data generated with three coded chemicals tested in three independent experiments in each laboratory gave consistent predictions within laboratories. For the between-laboratory reproducibility, 9 of the 10 coded chemicals tested once in each laboratory provided consistent predictions among the three laboratories. These results suggested that EpiSensA has good transferability, as well as within- and between-laboratory reproducibility. Copyright © 2018 John Wiley & Sons, Ltd.

Academic attainment and special educational needs in extremely preterm children at 11 years of age: the EPICure study.

PubMed

Johnson, S; Hennessy, E; Smith, R; Trikic, R; Wolke, D; Marlow, N

2009-07-01

To assess academic attainment and special educational needs (SEN) in extremely preterm children in middle childhood. Of 307 extremely preterm (< or =25 weeks) survivors born in the UK and Ireland in 1995, 219 (71%) were re-assessed at 11 years of age and compared to 153 classmates born at term, using standardised tests of cognitive ability and academic attainment and teacher reports of school performance and SEN. Multiple imputation was used to correct for selective dropout. Extremely preterm children had significantly lower scores than classmates for cognitive ability (-20 points; 95% CI -23 to -17), reading (-18 points; -22 to -15) and mathematics (-27 points; -31 to -23). Twenty nine (13%) extremely preterm children attended special school. In mainstream schools, 105 (57%) extremely preterm children had SEN (OR 10; 6 to 18) and 103 (55%) required SEN resource provision (OR 10; 6 to 18). Teachers rated 50% of extremely preterm children as having below average attainment compared with 5% of classmates (OR 18; 8 to 41). Extremely preterm children who entered compulsory education an academic year early due to preterm birth had similar academic attainment but required more SEN support (OR 2; 1.0 to 3.6). Extremely preterm survivors remain at high risk for learning impairments and poor academic attainment in middle childhood. A significant proportion require full-time specialist education and over half of those attending mainstream schools require additional health or educational resources to access the national curriculum. The prevalence and impact of SEN are likely to increase as these children approach the transition to secondary school.

A Study of Gaps in Attack Analysis

DTIC Science & Technology

2016-10-12

2014. [86] Shobha Venkataraman , David Brumley, Subhabrata Sen, and Oliver Spatscheck. Automati- cally Inferring the Evolution of Malicious Activity on...Shobha Venkataraman , Subhabrata Sen, Oliver Spatscheck, Patrick Haffner, and Dawn Song. Exploiting Network Structure for Proactive Spam Mitigation. In

A Study of Gaps in Attack Analysis

DTIC Science & Technology

2016-01-21

www.threatstream.com/blog/shockpot-exploitation-analysis, September 2014. [86] Shobha Venkataraman , David Brumley, Subhabrata Sen, and Oliver...NDSS 2013, San Diego, California, USA, February 24-27, 2013, 2013. [87] Shobha Venkataraman , Subhabrata Sen, Oliver Spatscheck, Patrick Haffner, and

EPA IG Response to Senate Committee on Environment and Public Works Ranking Member Carper and Sen. Whitehouse

EPA Pesticide Factsheets

These letters respond to correspondence received by Inspector General Arthur Elkins from Senate Committee on Environment and Public Works Ranking Member Tom Carper and Sen. Sheldon Whitehouse on May 2, 2018.

UNITEC SENS-IT

EPA Science Inventory

The UniTec Sens-It is a small gas-sensing device that can measure volatile organic compounds (VOCs). This sensor is used to measure VOCs in applications such as urban air quality, roadside pollution, and (solid waste) landfill monitoring. This operating procedure explains what yo...

Global Energy-saving Map of Strong Ocean Currents

DTIC Science & Technology

2015-01-01

Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan) 2(Department of Oceanography, National Sun Yat-sen University, Kaohsiung...World Bank and FAO. (2009). The sunken billions. The economic justification for fisheries reform. Washington, DC, Agriculture and Rural Development

Sen. John C. Stennis celebrates a successful Space Shuttle Main Engine test

NASA Technical Reports Server (NTRS)

1978-01-01

Sen. John C. Stennis dances a jig on top of the Test Control Center at Stennis Space Center following the successful test of a Space Shuttle Main Engine in 1978. A staunch supporter of the National Aeronautics and Space Administration (NASA), the senior senator from DeKalb, Miss., supported the establishment of the space center in Hancock County and spoke personally with local residents who would relocate their homes to accommodate Mississippi's entry into the space age. Stennis Space Center was named for Sen. Stennis by Executive Order of President Ronald Reagan on May 20, 1988.

Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines

PubMed Central

Caughey, Winslow S.; Raymond, Lynne D.; Horiuchi, Motohiro; Caughey, Byron

1998-01-01

A central aspect of pathogenesis in the transmissible spongiform encephalopathies or prion diseases is the conversion of normal protease-sensitive prion protein (PrP-sen) to the abnormal protease-resistant form, PrP-res. Here we identify porphyrins and phthalocyanines as inhibitors of PrP-res accumulation. The most potent of these tetrapyrroles had IC50 values of 0.5–1 μM in scrapie-infected mouse neuroblastoma (ScNB) cell cultures. Inhibition was observed without effects on protein biosynthesis in general or PrP-sen biosynthesis in particular. Tetrapyrroles also inhibited PrP-res formation in a cell-free reaction composed predominantly of hamster PrP-res and PrP-sen. Inhibitors were found among phthalocyanines, deuteroporphyrins IX, and meso-substituted porphines; examples included compounds containing anionic, neutral protic, and cationic peripheral substituents and various metals. We conclude that certain tetrapyrroles specifically inhibit the conversion of PrP-sen to PrP-res without apparent cytotoxic effects. The inhibition observed in the cell-free conversion reaction suggests that the mechanism involved direct interactions of the tetrapyrrole with PrP-res and/or PrP-sen. These findings introduce a new class of inhibitors of PrP-res formation that represents a potential source of therapeutic agents for transmissible spongiform encephalopathies. PMID:9770449

Chronic beryllium disease and beryllium sensitization at Rocky Flats: a case-control study.

PubMed

Viet, S M; Torma-Krajewski, J; Rogers, J

2000-01-01

A case-control study was conducted to evaluate the risk of chronic beryllium disease (CBD) and beryllium sensitization (SENS) associated with various levels of historical beryllium exposure at the Rocky Flats nuclear weapons facility. Fifty CBD and 74 SENS cases were matched to controls of the same age group, race, gender, and smoking status. A job exposure matrix was developed from job history data and fixed airhead (FAH) exposure data available from 1960 to 1988. Job titles and building areas were assigned factors based on exposure relative to a machinist in the Building 444 Beryllium Shop. Concurrence on these factors was obtained from past and present Rocky Flats industrial hygienists. Using the matrix, long-term mean and cumulative exposures were estimated for each subject. Both exposure estimates (p < 0.0001) and years of employment (p = 0.010) were found to be significantly higher for CBD cases as compared with their controls, but not so for the SENS cases as compared with their controls. Logistic regression analyses showed statistically significant relationships between both cumulative and mean exposure and CBD, but not for SENS. These findings suggest that reduced worker exposures might lower the future incidence of CBD, but may not necessarily lower the incidence of SENS.

Some Experience Using SEN2COR

NASA Astrophysics Data System (ADS)

Pflug, Bringfried; Bieniarz, Jakub; Debaecker, Vincent; Louis, Jérôme; Müller-Wilms, Uwe

2016-04-01

ESA has developed and launched the Sentinel-2A optical imaging mission that delivers optical data products designed to feed downstream services mainly related to land monitoring, emergency management and security. Many of these applications require accurate correction of satellite images for atmospheric effects to ensure the highest quality of scientific exploitation of Sentinel-2 data. Therefore the atmospheric correction processor Sen2Cor was developed by TPZ V on behalf of ESA. TPZ F and DLR have teamed up in order to provide the calibration and validation of the Level-2A processor Sen2Cor. Level-2A processing is applied to Top-Of-Atmosphere (TOA) Level-1C ortho-image reflectance products. Level-2A main output is the Bottom-Of-Atmosphere (BOA) corrected reflectance product. Additional outputs are an Aerosol Optical Thickness (AOT) map, a Water Vapour (WV) map and a Scene Classification (SC) map with Quality Indicators for cloud and snow probabilities. The poster will present some processing examples of Sen2Cor applied to Sentinel-2A data together with first performance investigations. Different situations will be covered like processing with and without DEM (Digital Elevation Model). Sen2Cor processing is controlled by several configuration parameters. Some examples will be presented demonstrating the influence of different settings of some parameters.

Gambling Related Cognitive Distortions in Adolescence: Relationships with Gambling Problems in Typically Developing and Special Needs Students.

PubMed

Taylor, Robyn N; Parker, James D A; Keefer, Kateryna V; Kloosterman, Patricia H; Summerfeldt, Laura J

2015-12-01

The present study examined the link between problematic gambling and gambling related cognitions (GRCs) in a large sample of adolescents with (N = 266) and without (N = 1,738) special education needs (SEN) between the ages of 14 and 18 years attending several high schools in eastern central Ontario. The adolescents with SENs were identified as having various learning disorders and/or internalizing and externalizing problems [e.g., attention deficit hyperactivity disorder (ADHD)]. All adolescents completed a self-report questionnaire package that included the GRC Scale (GRCS; Raylu and Oei in Addiction 99:757-769, 2004), as well as measures of problem gambling, negative affect, and ADHD symptomatology. Results showed that adolescents with SEN hold more erroneous beliefs about gambling and had a higher risk of developing problematic patterns of gambling behaviour than their typically developing peers. Moreover, the GRCS subscales were found to be strong predictors of problem gambling among adolescents both with and without SEN, accounting for a substantial amount of the variance even when controlling for the effects of age, gender, ADHD, and negative affect. It is suggested that intervention and prevention programs aimed at adolescent gambling need to give particular attention to those with SEN.

Developing the Model for Optimal Learning and Transfer (MOLT) Following an Evaluation of Outdoor Groupwork Skills Programmes

ERIC Educational Resources Information Center

Cooley, Sam Joseph; Cumming, Jennifer; Holland, Mark J. G.; Burns, Victoria E.

2015-01-01

Purpose: This paper aims to evaluate the perceived efficacy of outdoor groupwork skills programmes for the undergraduate and postgraduate students, and the factors that influence its success. It also illustrates the use of Kirkpatrick's (1994) 4-level model of training evaluation as a framework for qualitative investigation of learning and…

Evaluating Vocational Educators' Training Programs: A Kirkpatrick-Inspired Evaluation Model

ERIC Educational Resources Information Center

Ravicchio, Fabrizio; Trentin, Guglielmo

2015-01-01

The aim of the article is to describe the assessment model adopted by the SCINTILLA Project, a project in Italy aimed at the online vocational training of young, seriously-disabled subjects and their subsequent work inclusion in smart-work mode. It will thus describe the model worked out for evaluation of the training program conceived for the…

Microcomputer Interfaces with U.S. Marine Corps Tactical Communications Systems,

DTIC Science & Technology

1991-04-01

Schneider and Mrs. Kirkpatrick at the Communications officer School Quantico, Virginia This document has been approvedf or p,bic Yleaze cncd sae; its...communications systems; however, there is not a comprehensive USMC Command, Control, Communications, and Computers (C4) operational policy that documents these...5-6 COMMUNICATIONS SYSTEMS .... ............. 5-6 ADP SYSTEMS ....... .................. 5-6 OPERATIONAL POLICIES

Training Professionals' Usage and Understanding of Kirkpatrick's Level 3 and Level 4 Evaluations

ERIC Educational Resources Information Center

Kennedy, Perri Estes; Chyung, Seung Youn; Winiecki, Donald J.; Brinkerhoff, Robert O.

2014-01-01

Training professionals have long acknowledged the necessity of conducting behavior-based (Level 3) and results-based (Level 4) evaluations, yet organizations do not frequently conduct such evaluations. This research examined training professionals' perceptions of the utility of Level 3 and Level 4 evaluations and the factors that facilitate…

Genomics Analogy Model for Educators (GAME): From Jumping Genes to Alternative Splicing

ERIC Educational Resources Information Center

Corn, Joanie; Pittendrigh, Barry R.; Orvis, Kathryn S.

2004-01-01

Studies have shown that there is usually a lack of understanding concerning the fields of genetics and genomics among high school students (Lewis and Wood-Robinson, 2000). A recent article (Kirkpatrick et al, 2002) introduced the GAME (Genomics Analogy Model for Educators) model and two of its components: (1) explaining sequencing technology with…

Using Outdoor Adventure Education to Develop Students' Groupwork Skills: A Quantitative Exploration of Reaction and Learning

ERIC Educational Resources Information Center

Cooley, Sam J.; Burns, Victoria E.; Cumming, Jennifer

2016-01-01

This study investigates the initial development of groupwork skills through outdoor adventure education (OAE) and the factors that predict the extent of this development, using the first two levels of Kirkpatrick's model of training evaluation. University students (N = 238) completed questionnaires measuring their initial reactions to OAE (Level 1…

Effective Dementia Education and Training for the Health and Social Care Workforce: A Systematic Review of the Literature

ERIC Educational Resources Information Center

Surr, Claire A.; Gates, Cara; Irving, Donna; Oyebode, Jan; Smith, Sarah Jane; Parveen, Sahdia; Drury, Michelle; Dennison, Alison

2017-01-01

Ensuring an informed and effective dementia workforce is of international concern; however, there remains limited understanding of how this can be achieved. This review aimed to identify features of effective dementia educational programs. Critical interpretive synthesis underpinned by Kirkpatrick's return on investment model was applied. One…

Functional genomics annotation of a statistical epistasis network associated with bladder cancer susceptibility.

PubMed

Hu, Ting; Pan, Qinxin; Andrew, Angeline S; Langer, Jillian M; Cole, Michael D; Tomlinson, Craig R; Karagas, Margaret R; Moore, Jason H

2014-04-11

Several different genetic and environmental factors have been identified as independent risk factors for bladder cancer in population-based studies. Recent studies have turned to understanding the role of gene-gene and gene-environment interactions in determining risk. We previously developed the bioinformatics framework of statistical epistasis networks (SEN) to characterize the global structure of interacting genetic factors associated with a particular disease or clinical outcome. By applying SEN to a population-based study of bladder cancer among Caucasians in New Hampshire, we were able to identify a set of connected genetic factors with strong and significant interaction effects on bladder cancer susceptibility. To support our statistical findings using networks, in the present study, we performed pathway enrichment analyses on the set of genes identified using SEN, and found that they are associated with the carcinogen benzo[a]pyrene, a component of tobacco smoke. We further carried out an mRNA expression microarray experiment to validate statistical genetic interactions, and to determine if the set of genes identified in the SEN were differentially expressed in a normal bladder cell line and a bladder cancer cell line in the presence or absence of benzo[a]pyrene. Significant nonrandom sets of genes from the SEN were found to be differentially expressed in response to benzo[a]pyrene in both the normal bladder cells and the bladder cancer cells. In addition, the patterns of gene expression were significantly different between these two cell types. The enrichment analyses and the gene expression microarray results support the idea that SEN analysis of bladder in population-based studies is able to identify biologically meaningful statistical patterns. These results bring us a step closer to a systems genetic approach to understanding cancer susceptibility that integrates population and laboratory-based studies.

OIG News Release: EPA IG responds to open letter from Sen. Vitter

EPA Pesticide Factsheets

U.S. Environmental Protection Agency (EPA) Inspector General Arthur A. Elkins Jr. has responded to a letter signed and released to the public February 18 by U.S. Sen. David Vitter, Ranking Member of the Committee on Environment and Public Works.

Optimal sample formulations for DNP SENS: The importance of radical-surface interactions

DOE PAGES

Perras, Frederic A.; Wang, Lin-Lin; Manzano, J. Sebastian; ...

2017-11-15

The efficacy of dynamic nuclear polarization (DNP) surface-enhanced NMR spectroscopy (SENS) is reviewed for alumina, silica, and ordered mesoporous carbon (OMC) materials, with vastly different surface areas, as a function of the biradical concentration. Importantly, our studies show that the use of a “one-size-fits-all” biradical concentration should be avoided when performing DNP SENS experiments and instead an optimal concentration should be selected as appropriate for the type of material studied as well as its surface area. In general, materials with greater surface areas require higher radical concentrations for best possible DNP performance. This result is explained with the use ofmore » a thermodynamic model wherein radical-surface interactions are expected to lead to an increase in the local concentration of the polarizing agent at the surface. We also show, using plane-wave density functional theory calculations, that weak radical-surface interactions are the cause of the poor performance of DNP SENS for carbonaceous materials.« less

Early Validation of Sentinel-2 L2A Processor and Products

NASA Astrophysics Data System (ADS)

Pflug, Bringfried; Main-Knorn, Magdalena; Bieniarz, Jakub; Debaecker, Vincent; Louis, Jerome

2016-08-01

Sentinel-2 is a constellation of two polar orbiting satellite units each one equipped with an optical imaging sensor MSI (Multi-Spectral Instrument). Sentinel-2A was launched on June 23, 2015 and Sentinel-2B will follow in 2017.The Level-2A (L2A) processor Sen2Cor implemented for Sentinel-2 data provides a scene classification image, aerosol optical thickness (AOT) and water vapour (WV) maps and the Bottom-Of-Atmosphere (BOA) corrected reflectance product. First validation results of Sen2Cor scene classification showed an overall accuracy of 81%. AOT at 550 nm is estimated by Sen2Cor with uncertainty of 0.035 for cloudless images and locations with dense dark vegetation (DDV) pixels present in the image. Aerosol estimation fails if the image contains no DDV-pixels. Mean difference between Sen2Cor WV and ground-truth is 0.29 cm. Uncertainty of up to 0.04 was found for the BOA- reflectance product.

Amartya Sen's Capability Approach and Education

ERIC Educational Resources Information Center

Walker, Melanie

2005-01-01

The human capabilities approach developed by the economist Amartya Sen links development, quality of life and freedom. This article explores the key ideas in the capability approach of: capability, functioning, agency, human diversity and public participation in generating valued capabilities. It then considers how these ideas relate specifically…

OIG News Release: EPA IG responds to memo from agency’s Deputy Administrator challenging ‘context’ of responses to Sen. Vitter’s questions

EPA Pesticide Factsheets

EPA Inspector General (IG) Arthur A. Elkins Jr. today responded to a February 27 memorandum from EPA Deputy Administrator Bob Perciasepe addressing the IG's recent correspondence with U.S. Sen. David Vitter.

Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae.

PubMed

Sariki, Santhosh Kumar; Sahu, Pushpendra Kumar; Golla, Upendarrao; Singh, Vikash; Azad, Gajendra Kumar; Tomar, Raghuvir S

2016-11-01

Mutations in the Senataxin gene, SETX are known to cause the neurodegenerative disorders, ataxia with oculomotor apraxia type 2 (AOA2), and amyotrophic lateral sclerosis 4 (ALS4). However, the mechanism underlying disease pathogenesis is still unclear. The Senataxin N-terminal protein-interaction and C-terminal RNA/DNA helicase domains are conserved in the Saccharomyces cerevisiae homolog, Sen1p. Using genome-wide expression analysis, we first show alterations in key cellular pathways such as: redox, unfolded protein response, and TOR in the yeast sen1 ΔN mutant (N-terminal truncation). This mutant exhibited growth defects on nonfermentable carbon sources, was sensitive to oxidative stress, and showed severe loss of mitochondrial DNA. The growth defect could be partially rescued upon supplementation with reducing agents and antioxidants. Furthermore, the mutant showed higher levels of reactive oxygen species, lower UPR activity, and alterations in mitochondrial membrane potential, increase in vacuole acidity, free calcium ions in the cytosol, and resistance to rapamycin treatment. Notably, the sen1 ∆N mutant showed increased cell death and shortened chronological life span. Given the strong similarity of the yeast and human Sen1 proteins, our study thus provides a mechanism for the progressive neurological disorders associated with mutations in human senataxin. © 2016 Federation of European Biochemical Societies.

Comparison of SensL and Hamamatsu 4×4 channel SiPM arrays in gamma spectrometry with scintillators

NASA Astrophysics Data System (ADS)

Grodzicka-Kobylka, M.; Szczesniak, T.; Moszyński, M.

2017-06-01

The market of Silicon Photomultipliers (SiPMs) consists of many manufacturers that produce their detectors in different technology. Hamamatsu (Japan) and SensL (Ireland) seems to be the most popular companies that produce large SiPM arrays. The aim of this work is characterization and comparison of 4×4 channel SiPM arrays produced by these two producers. Both of the tested SiPMs are made in through-silicon via (TSV) technology, consist of 16, 3×3 mm avalanche photodiode (APD) cells and have fill factor slightly above 60%. The largest difference is a single APD cell size and hence total number of APD cells (55,424 for Hamamatsu, 76,640 for SensL). In the case of SensL SiPM, its spectral response characteristics is shifted slightly toward shorter wavelengths with maximum at 420 nm (450 nm for Hamamatsu). The presented measurements cover selection of the SiPM optimum operating voltage (in respect to energy resolution), verification of the excess noise factor and check of the linearity characteristics. Moreover, the gamma spectrometry with LSO, BGO and CsI:Tl scintillators together with pulse characteristics for these crystals (rise time and fall time) is reported, as well as temperature dependence. The presented measurements show better performance of the SensL array comparing to the Hamamatsu detector.

Professional Development of New Higher Education Teachers with Information and Communication Technology in Shanghai: A Kirkpatrick's Evaluation Approach

ERIC Educational Resources Information Center

Wu, Bian; Hu, Yiling; Gu, Xiaoqing; Lim, Cher Ping

2016-01-01

As information and communication technology (ICT) continues to develop, it is essential for teachers to acquire ability for teaching with ICT. In China, new higher education (HE) teachers often lack teaching experience because there are limited teaching opportunities during their postgraduate studies. This status quo may compromise the quality of…

HYBRID simulations of diffraction-limited focusing with Kirkpatrick-Baez mirrors for a next-generation In Situ hard X-ray nanoprobe

DOE PAGES

Maser, Jorg; Shi, Xianbo; Reininger, Ruben; ...

2016-02-22

Next-generation hard X-ray nanoprobe beamlines such as the In Situ Nanoprobe (ISN) beamline being planned at the Advanced Photon Source aim at providing very high spatial resolution while also enabling very high focused flux, to study complex materials and devices using fast, multidimensional imaging across many length scales. The ISN will use diffractive optics to focus X-rays with a bandpass of ΔE/E = 10 –4 into a focal spot of 20 nm or below. Reflective optics in Kirkpatrick-Baez geometry will be used to focus X-rays with a bandpass as large as ΔE/E = 10 –2 into a focal spot ofmore » 50 nm. Diffraction-limited focusing with reflective optics is achieved by spatial filtering and use of a very long, vertically focusing mirror. Furthermore, to quantify the performance of the ISN beamline, we have simulated the propagation of both partially and fully coherent wavefronts from the undulator source, through the ISN beamline and into the mirror-based focal spot. Simulations were carried out using the recently developed software “HYBRID.”« less

Clinical Simulation in Psychiatric-Mental Health Nursing: Post-Graduation Follow Up.

PubMed

Lilly, Mary LuAnne; Hermanns, Melinda; Crawley, Bill

2016-10-01

In psychiatric-mental health, creating an innovative strategy to help students learn content that may not be frequently seen in a clinical setting is challenging. Thus, simulation helps narrow this gap. Using Kirkpatrick and Kirkpatrick's model of evaluation to guide the current study, faculty contacted baccalaureate nursing program graduates who completed a psychiatric-mental health clinical simulation scenario featuring a hanging suicide and wrist cutting suicide attempt scenario in the "Behind the Door" series as part of the clinical component of their undergraduate psychiatric-mental health course. Eleven nurses responded to a survey regarding their post-graduate encounters with these types of clinical situations, and their perception of recall and application of knowledge and skills acquired during the simulation experience to the clinical situation. Nursing graduates' responses are expressed through three major themes: emotional, contextual/behavioral, and assessment outcomes. Data from the survey indicate that nursing graduates perceived the "Behind the Door" simulations as beneficial to nursing practice. This perception is important in evaluating knowledge transfer from a simulation experience as a student into application in nursing practice. [Journal of Psychosocial Nursing and Mental Health Services, 54(10), 40-45.]. Copyright 2016, SLACK Incorporated.

Triassic-Jurassic sediments and multiple volcanic events in North Victoria Land, Antarctica: A revised stratigraphic model

USGS Publications Warehouse

Schöner, R.; Viereck-Goette, L.; Schneider, J.; Bomfleur, B.

2007-01-01

Field investigations in North Victoria Land, Antarctica during GANOVEX IX (2005/2006) allow the revision of the Triassic-Jurassic stratigraphy of ~300 m thick continental deposits in between the crystalline basement and the Kirkpatrick lava flows of the Ferrar Group. The lower stratigraphic unit (Section Peak Formation) is characterised by braided river-type quartzose sandstone deposits with intercalations of shale and coal occurring at the top. It is overlain by a homogeneous unit of reworked tuffs composed of fine-grained silicic shards, quartz and feldspar (new name: "Shafer Peak Formation"). These deposits can be correlated with parts of the Hanson Formation in the Central Transantarctic Mountains and require a distal yet unknown source of massive silicic volcanism. Clastic products of mafic volcanic eruptions, formerly described as a separate stratigraphic formation (Exposure Hill Formation), occur within local diatreme structures as well as intercalated at various stratigraphic levels within the sedimentary succession. These dominantly hydroclastic eruptions are the first subaerial expression of Ferrar magmatism. The initial Kirkpatrick lavas/pillow lavas were generated from local eruptive centres and again may be overlain by thin sediments, which are covered by the thick plateau lava succession known throughout the Transantarctic Mountain Range.

Possible ergodic-nonergodic regions in the quantum Sherrington-Kirkpatrick spin glass model and quantum annealing

NASA Astrophysics Data System (ADS)

Mukherjee, Sudip; Rajak, Atanu; Chakrabarti, Bikas K.

2018-02-01

We explore the behavior of the order parameter distribution of the quantum Sherrington-Kirkpatrick model in the spin glass phase using Monte Carlo technique for the effective Suzuki-Trotter Hamiltonian at finite temperatures and that at zero temperature obtained using the exact diagonalization method. Our numerical results indicate the existence of a low- but finite-temperature quantum-fluctuation-dominated ergodic region along with the classical fluctuation-dominated high-temperature nonergodic region in the spin glass phase of the model. In the ergodic region, the order parameter distribution gets narrower around the most probable value of the order parameter as the system size increases. In the other region, the Parisi order distribution function has nonvanishing value everywhere in the thermodynamic limit, indicating nonergodicity. We also show that the average annealing time for convergence (to a low-energy level of the model, within a small error range) becomes system size independent for annealing down through the (quantum-fluctuation-dominated) ergodic region. It becomes strongly system size dependent for annealing through the nonergodic region. Possible finite-size scaling-type behavior for the extent of the ergodic region is also addressed.

Effectiveness of Online Cancer Education for Nurses and Allied Health Professionals; a Systematic Review Using Kirkpatrick Evaluation Framework.

PubMed

Campbell, Karen; Taylor, Vanessa; Douglas, Sheila

2017-12-12

Embedding online learning within higher education can provide engaging, cost-effective, interactive and flexible education. By evaluating the impact, outcomes and pedagogical influence of online cancer and education, future curricula can be shaped and delivered by higher education providers to better meet learner, health care provider and educational commissioners' requirements for enhanced patient care and service delivery needs. Using the Kirkpatrick's four-level model of educational evaluation, a systematic review of the effectiveness of online cancer education for nurses and allied health professionals was conducted. From 101 articles, 30 papers were included in the review. Educational theory is not always employed. There is an absence of longitudinal studies to examine impact; an absence of reliability and/or validity testing of measures, limited experimental designs taking account of power and few attempts to mitigate bias. There is, however, an emerging innovative use of mobile/spaced learning techniques. Evidence for clinical and educational effectiveness is weak offering insights into experiences and participant perceptions rather than concrete quantitative data and patient-reported outcomes. More pedagogical research is merited to inform effective evaluation of online cancer education, which incorporates and demonstrates a longer-term impact.

Selecting Capabilities for Quality of Life Measurement

ERIC Educational Resources Information Center

Robeyns, Ingrid

2005-01-01

The capability approach advocates that interpersonal comparisons be made in the space of functionings and capabilities. However, Amartya Sen has not specified which capabilities should be selected as the relevant ones. This has provoked two types of criticism. The stronger critique is Martha Nussbaum's claim that Sen should endorse one specific…

The Role of the U.S. Army in Health System Reconstruction and Development During Counterinsurgency

DTIC Science & Technology

2012-06-08

freedom. — Amartya Sen Development as Freedom Military medical personnel involved in health system reconstruction and development in Iraq and...Afghanistan. New York: W.W. Norton and Company, 2009. Sen , Amartya . Development as Freedom. New York: Anchor Books, 2000. Special Inspector General for

Primary Schooling in West Bengal

ERIC Educational Resources Information Center

Sen, Amartya

2010-01-01

With his Nobel Prize award money, Amartya Sen set up the Pratichi Trust which carries out research, advocacy and experimental projects in basic education, primary health care, and women's development in West Bengal and Bangladesh. Professor Sen himself took active interest in this work--helping set the agenda, looking at the evidence from…

Understanding Indian Insurgencies: Implications for Counterinsurgency Operations in the Third World

DTIC Science & Technology

2005-12-01

contested area (e.g., Lenin in France and Austria, Sun Yat- Sen in Japan, Fidel Castro in Mexico, Che Guevara in Mexico, Hekmatyar in Pakistan, and Ho Chi...Princeton University Press. Sageman, M. (2004). Understanding terror networks. Philadelphia: University of Pennsylvania Press. Sen , A. (1999). World

Economic Valuation of Air Force Environmental Resources: A Contingent Valuation Case Study.

DTIC Science & Technology

1996-12-01

Empirical Measures of Welfare Change: A Comparison of Non-market Techniques," Land Economics: 156-175 (Vol. 61, No. 2, 1985). Sen , Amartya K...shackles of the traditional [observed] approach" ( Sen , 1977). The flexibility of a properly designed contingent valuation study allows CVM to measure

Individual Freedom and Institutional Frameworks in Development

ERIC Educational Resources Information Center

Allen, Nicholas

2012-01-01

In this article I explore Amartya Sen's contention that individual freedom represents both the objective of development and the means through which development is to take place. Examining the conceptualisation of freedom central to Sen's capability approach, I distinguish between two notions of freedom, autonomy and agency, where the former…

Working Memory: Its Role in Dyslexia and Other Specific Learning Difficulties

ERIC Educational Resources Information Center

Jeffries, Sharman; Everatt, John

2004-01-01

This paper reports a study contrasting dyslexic children against a control group of children without special educational needs (SEN) and a group with varied SENs. Children's abilities were compared on tasks assessing phonological processing, visuo-spatial/motor coordination and executive/inhibitory functioning; being targeted for assessment based…

Ethical Accountability and Routine Moral Stress in Special Educational Needs Professionals

ERIC Educational Resources Information Center

Hellawell, Beate

2015-01-01

This small-scale interview study considers experiences, difficulties and dilemmas of local Special Educational Needs (SEN) professionals such as SEN caseworkers, and examines the neglected ethical dimensions of their role. It argues that fostering "ethical knowledge" (Campbell, 2003), rather than an increase in prescriptive guidance,…

A Cross-Cultural Conflict Reexamined: Annette Akroyd and Keshub Chunder Sen.

ERIC Educational Resources Information Center

Scherer, M. A.

1996-01-01

Reexamines a well-known conflict between Unitarian reformer, Annette Akroyd, and Hindu liberal, Keshub Chunder Sen, over the administration of a private girls' school in 19th century India. Argues that previous interpretations stressing colonial ethnocentrism failed to take into account the complexity of the situation. (MJP)

IG Statement: EPA Inspector General Responds to Sen. Inhofe's Letter about Review of Hydraulic Fracturing

EPA Pesticide Factsheets

EPA IG Arthur Elkins Jr. responded to Sen. James Inhofe’s Oct 2, 2014, letter asserting that the EPA OIG should not proceed with a program evaluation of the EPA’s and states’ ability to manage potential threats to water resources from hydraulic fracturing.

A General Approach to Nonrigid Registration: Decoupled Optimization

DTIC Science & Technology

2001-10-25

Juan Ruiz-Alzola Dep. Señales y Comunicaciones . Universidad de Las Palmas de Gran Canaria, SPAIN Dep. Teorı́a de la Señal,Universidad de...s) and Address(es) Dep. Senales y Communicaciones Universidad de Las Palma de Gran Canaria, Spain Performing Organization Report Number Sponsoring

Autistic Spectrum Disorders and Primary-Secondary Transition

ERIC Educational Resources Information Center

Jindal-Snape, D.; Douglas, W.; Topping, K. J.; Kerr, C.; Smith, E. F.

2006-01-01

Transition from primary to secondary school has been a focus of concern regarding pupil anxiety, social integration, lack of progression and under-achievement, particularly for children/young people with special educational needs (SEN). Previous studies often over-depended on data from professionals and treated all SEN as similar. This study…

Student Voices on Social Exclusion in General Primary Schools

ERIC Educational Resources Information Center

de Leeuw, R. R.; de Boer, A. A.; Minnaert, A. E. M. G.

2018-01-01

Advocates of inclusive education argue that the social inclusion of students with secial educational needs (SEN) increases when they are educated with tyically develoing eers. However, research indicates that this is not aarent for all students with SEN. Students with social, emotional and behavioural difficulties (SEBD) are often socially…

The Northern Ireland Resource File and Aspire

ERIC Educational Resources Information Center

Ryan, David; Montgomery, Brenda

2016-01-01

The paper begins by identifying issues as to how initial teacher training and in-service training for teachers inadequately prepares them for teaching the pupils with special educational needs (SEN). The paper then provides a brief legislative background to SEN in the Northern Ireland context, before describing two elements of educational reform…

Managing Current Developments in SEN and Inclusion: Developing Confidence in New Teachers

ERIC Educational Resources Information Center

Richards, Gill

2010-01-01

Developments in special and inclusive education have lead to increasing challenges for teachers. Initial Teacher Education has struggled to keep pace with these developments and equip all newly qualified teachers with the skills required to meet the needs of children with SEN. This paper reflects upon recent national initiatives designed to…

U.S. Democracy Promotion and Al Jazeera: A View into Arab Reactions and Opposing Movements

DTIC Science & Technology

2005-09-01

New York Time, 13 April, 2000, http://www.stanford.edu/~wacziarg/articles/nytdemoc/nytdemoc.html (accessed 11 December 2004). 9. Amartya Sen ...February 12, 2005, 106 http://www.jsonline.com/news/editorials/feb05/301034.asp (accessed August 22, 2005). Sen , Amartya . “Democracy as a

The Chinese Century: Sino-American Relations -- Change, Challenges, and Opportunities in the 21st Century

DTIC Science & Technology

2006-03-15

immoral and it is dangerous” to view the Western emphasis on individualism as universal. (p.310) 114 Harvard professor, Amartya Sen argues... Amartya Sen , “Human Rights and Asian Values,” Sixteenth Morgenthau Memorial Lecture on Ethics and Foreign Policy (New York: Carnegie Council on Ethics

Game Theory, Decision Theory, and Social Choice Theory in the Context of a New Theory of Equity

DTIC Science & Technology

1978-12-01

Press of Harvard University. Sen , Amartya , 1977, "On Weights and Measures: Informational Constraints in Social Welfare Analysis," Econometrica, Vol...this requirement is a natural consequence of a setup that rules out cardinal utility, as Arrow (1978) and Sen (1977) have pointed out in different

Teachers' Perspectives Surrounding ICT Use amongst SEN Students in the Mainstream Educational Setting

ERIC Educational Resources Information Center

Abed, Mohaned Ghazi

2018-01-01

At the present time, ICT (Information and Communication Technology) is recognised as a pressing consideration in educational establishments worldwide. Accordingly, the present research proved to be valuable to teaching staff, teachers in (Special Educational Needs) SEN and leaders in schools. This work's aim was centred on explaining and examining…

Commentary on "Education, Employment and Human Development: Illustrations from Mexico"

ERIC Educational Resources Information Center

Strathdee, Rob

2007-01-01

Flores-Crespo has written a timely paper, "Education, employment and human development: illustrations from Mexico". Flores-Crespo uses Amartya Sen's ideas to bring a fresh perspective to bear on the relationship between higher education and human development. Although there is growing interest in applying Sen's ideas in a range of…

Review of the Literature on Children with Special Educational Needs

ERIC Educational Resources Information Center

Alkahtani, Mohammed Ali

2016-01-01

This study outlines the literature relevant to the Cross-cultural issues and the politics of SEN and the different perspectives arising from the literature on this widely debated issue are addressed. In addition, the origin of the term "special educational needs" (SEN), its definitions and the types of special education needs are…

Characteristics of Primary Teacher Training Programmes on Inclusion: A Literature Focus

ERIC Educational Resources Information Center

Kurniawati, Farida; De Boer, Anke A.; Minnaert, A. E. M. G.; Mangunsong, Frieda

2014-01-01

Background: The implementation of inclusive education creates challenges for classroom teachers who have to meet the learning needs of students with and without special educational needs (SEN). Research has revealed that teachers' readiness and willingness to accommodate the learning needs of students with SEN was determined by their…

Manifestations of "Capabilities Poverty" with Learners Attending Informal Settlement Schools

ERIC Educational Resources Information Center

Maarman, Rouaan

2009-01-01

In this study I use the notion of "capabilities poverty", as theorised by Sen, to examine the experiences of learners attending informal settlement schools in North-West Province, South Africa. Sen distinguishes between functionings (what people do or their ability to do something) and capabilities (various combinations of what people…

Voices of Students with Special Educational Needs (SEN): Views on Schooling

ERIC Educational Resources Information Center

Prunty, Anita; Dupont, Maeve; McDaid, Rory

2012-01-01

As important decisions are being made with regard to educational legislation, policy and provision for children with special educational needs (SEN), it is critical that the views of these key stakeholders are heard and considered. This article reports the perspectives of 38 children and young people with special educational needs on their…

Erasmus Mundus SEN: The Inclusive Scholarship Programme?

ERIC Educational Resources Information Center

Grinbergs, Christopher J.; Jones, Hilary

2013-01-01

The Erasmus Mundus MA/Mgr in Special Education Needs (EM SEN) was created as a Masters Course funded by the European Commission's Erasmus Mundus Programme (EMP) to challenge and educate students in inclusive policy and practice in education. Yet, it is debatable the extent to which this programme embodies the values of an inclusive approach,…

Teaching Inclusively: Are Secondary Physical Education Student Teachers Sufficiently Prepared to Teach in Inclusive Environments?

ERIC Educational Resources Information Center

Coates, Janine Kim

2012-01-01

Background: Contemporary British educational guidelines, such as the National Curriculum (NC) have adopted inclusivity in the way children with special educational needs (SEN) are taught. Therefore, inclusion has risen up the political agenda, resulting in more children with SEN being taught in mainstream environments. Empirical research has…

Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome

PubMed Central

Carver, Melissa N.; Müller, Ulrika; Bekiranov, Stefan; Auble, David T.

2017-01-01

Transcriptome studies on eukaryotic cells have revealed an unexpected abundance and diversity of noncoding RNAs synthesized by RNA polymerase II (Pol II), some of which influence the expression of protein-coding genes. Yet, much less is known about biogenesis of Pol II non-coding RNA than mRNAs. In the budding yeast Saccharomyces cerevisiae, initiation of non-coding transcripts by Pol II appears to be similar to that of mRNAs, but a distinct pathway is utilized for termination of most non-coding RNAs: the Sen1-dependent or “NNS” pathway. Here, we examine the effect on the S. cerevisiae transcriptome of conditional mutations in the genes encoding six different essential proteins that influence Sen1-dependent termination: Sen1, Nrd1, Nab3, Ssu72, Rpb11, and Hrp1. We observe surprisingly diverse effects on transcript abundance for the different proteins that cannot be explained simply by differing severity of the mutations. Rather, we infer from our results that termination of Pol II transcription of non-coding RNA genes is subject to complex combinatorial control that likely involves proteins beyond those studied here. Furthermore, we identify new targets and functions of Sen1-dependent termination, including a role in repression of meiotic genes in vegetative cells. In combination with other recent whole-genome studies on termination of non-coding RNAs, our results provide promising directions for further investigation. PMID:28665995

Ribavirin, Interferon, and Antibody Approaches to Prophylaxis and Therapy for Viral Hemorrhagic Fevers

DTIC Science & Technology

1990-01-01

competitively inhibits intracellular pools of tive in preventing nosocomial infections (MMWR 1988, guanosine triphosphate required for viral nucleic...separation of cytotoxic and viral inhibitory activ- serious viral infections , they assume another dimension ities (Smith and Kirkpatrick, eds., Ribavirin, A...individuals or those exposed to clinical trials conducted since 1977, ribavirin has been self-limited viral infections must also take into account administered

Evaluation of the Effectiveness of a First Aid Health Volunteers' Training Programme Using Kirkpatrick's Model: A Pilot Study

ERIC Educational Resources Information Center

Vizeshfar, Fatemeh; Momennasab, Marzieh; Yektatalab, Shahrzad; Iman, Mohamad Taghi

2018-01-01

Objective: This study aimed to evaluate the effectiveness of a health volunteers' complementary training programme on first aid. Design: Quasi-experimental study. Setting: A comprehensive health centre in the southwest of Iran. Method: The study was conducted in the second half of 2015 with all 25 health volunteers in the Qamar Bani Hashem…

Evidence of Emperor Geese breeding in Russia and staging in Alaska

USGS Publications Warehouse

Schmutz, Joel A.; Kondratyev, Alexander V.

1995-01-01

Emperor Geese (Chen canagica) breed primarily on the Yukon-Kuskokwim Delta, Alaska (Eisenhauer and Kirkpatrick 1977), but a small, poorly quantified proportion of the world's population is known to breed in the Russia Far East (Kistchinski 1976, 1988, Portenko 1981). Eisenhauer and Kirkpatrick (1977) stated that 80 to 90% of all Emperor Geese breed on the Yukon-Kuskokwim Delta, Alaska, and current estimates for numbers of breeding pairs in this area are 20,000 to 25,000 (R. A. Stehn, National Biological Service, Anchorage, Alaska, unpubl. data). In Russia, Emperor Geese are distributed primarily along the north coast of the Chukotka Peninsula between Kolyuchin Bay and Cape Shmidt, and in the Anadyr Lowlands along the coast of Anadyr Bay (Fig. 1; Kistchinski 1988, Kondratyev 1992, 1993), Kistchinski (1976) noted that up to 80% of these geese are nonbreeding birds. Recent aerial surveys of Emperor Goose habitats along the eastern coast of Russia indicated a minimum of 3,000 to 5,000 geese, although very few were on nests or with young, and only 127 total broods were seen during these surveys (J. I. Hodges, Fish and Wildlife Service (FWS), Juneau, Alaska, unpubl. data) It is not known if these two continental distributions of breeding Emperor Geese commingle and use similar areas during migration and for winter. Aerial surveys of the Alaska Peninsula during spring and fall indicate that lagoons on the northern coast are the primary staging areas for this species, and it is presumed that virtually all Emperor Geese use the Alaska Peninsula during migration (Petersen and Gill 1982). Emperor Geese winter throughout the Aleutian and Kommandorsky islands (Byrd et al., 1974). In the late fall, geese arrive in the western and eastern Aleutian Islands before arriving in the central Aleutians, thus suggesting that geese may be coming to this wintering area from both continents (G. V. Byrd pers, comm.). Speculations of previous investigators that Emperor Geese breeding in Russia use the Alaska Peninsula for staging (Eisenhauer and Kirkpatrick 1977, A. Krechmar pers. comm.) have not been confirmed. Here we report observations of two geese banded as juveniles in Russia and observed on the Alaska Peninsula during their first fall migration.

Biological impact of α genes, β haplotypes, and G6PD activity in sickle cell anemia at baseline and with hydroxyurea

PubMed Central

Arnaud, Cécile; Kamdem, Annie; Hau, Isabelle; Lelong, Françoise; Epaud, Ralph; Pondarré, Corinne; Pissard, Serge

2018-01-01

Sickle cell anemia (SCA), albeit monogenic, has heterogeneous phenotypic expression, mainly related to the level of hemoglobin F (HbF). No large cohort studies have ever compared biological parameters in patients with major β-globin haplotypes; ie, Senegal (SEN), Benin (BEN), and Bantu/Central African Republic (CAR). The aim of this study was to evaluate the biological impact of α genes, β haplotypes, and glucose-6-phosphate dehydrogenase (G6PD) activity at baseline and with hydroxyurea (HU). Homozygous HbS patients from the Créteil pediatric cohort with available α-gene and β-haplotype data were included (n = 580; 301 females and 279 males) in this retrospective study. Homozygous β-haplotype patients represented 74% of cases (37.4% CAR/CAR, 24.3% BEN/BEN, and 12.1% SEN/SEN). HU was given to 168 cohort SCA children. Hematological parameters were recorded when HbF was maximal, and changes (ΔHU-T0) were calculated. At baseline, CAR-haplotype and α-gene numbers were independently and negatively correlated with Hb and positively correlated with lactate dehydrogenase. HbF was negatively correlated with CAR-haplotype numbers and positively with BEN- and SEN-haplotype numbers. The BCL11A/rs1427407 “T” allele, which is favorable for HbF expression, was positively correlated with BEN- and negatively correlated with CAR-haplotype numbers. With HU treatment, Δ and HbF values were positively correlated with the BEN-haplotype number. BEN/BEN patients had higher HbF and Hb levels than CAR/CAR and SEN/SEN patients. In conclusion, we show that BEN/BEN patients have the best response on HU and suggest that this could be related to the higher prevalence of the favorable BCL11A/rs1427407/T/allele for HbF expression in these patients. PMID:29555644

Sen2Cor for Sentinel-2

NASA Astrophysics Data System (ADS)

Main-Knorn, Magdalena; Pflug, Bringfried; Louis, Jerome; Debaecker, Vincent; Müller-Wilm, Uwe; Gascon, Ferran

2017-10-01

In the frame of the Copernicus programme, ESA has developed and launched the Sentinel-2 optical imaging mission that delivers optical data products designed to feed downstream services mainly related to land monitoring, emergency management and security. The Sentinel-2 mission is the constellation of two polar orbiting satellites Sentinel-2A and Sentinel-2B, each one equipped with an optical imaging sensor MSI (Multi-Spectral Instrument). Sentinel-2A was launched on June 23rd, 2015 and Sentinel-2B followed on March 7th, 2017. With the beginning of the operational phase the constellation of both satellites enable image acquisition over the same area every 5 days or less. To use unique potential of the Sentinel-2 data for land applications and ensure the highest quality of scientific exploitation, accurate correction of satellite images for atmospheric effects is required. Therefore the atmospheric correction processor Sen2Cor was developed by Telespazio VEGA Deutschland GmbH on behalf of ESA. Sen2Cor is a Level-2A processor which main purpose is to correct single-date Sentinel-2 Level-1C Top-Of-Atmosphere (TOA) products from the effects of the atmosphere in order to deliver a Level-2A Bottom-Of-Atmosphere (BOA) reflectance product. Additional outputs are an Aerosol Optical Thickness (AOT) map, a Water Vapour (WV) map and a Scene Classification (SCL) map with Quality Indicators for cloud and snow probabilities. Telespazio France and DLR have teamed up in order to provide the calibration and validation of the Sen2Cor processor. Here we provide an overview over the Sentinel-2 data, processor and products. It presents some processing examples of Sen2Cor applied to Sentinel-2 data, provides up-to-date information about the Sen2Cor release status and recent validation results at the time of the SPIE Remote Sensing 2017.

Transposon Mutagenesis of Salmonella enterica Serovar Enteritidis Identifies Genes That Contribute to Invasiveness in Human and Chicken Cells and Survival in Egg Albumen

PubMed Central

Zhou, Xiaohui; Kim, Hye-Young; Call, Douglas R.; Guard, Jean

2012-01-01

Salmonella enterica serovar Enteritidis is an important food-borne pathogen, and chickens are a primary reservoir of human infection. While most knowledge about Salmonella pathogenesis is based on research conducted on Salmonella enterica serovar Typhimurium, S. Enteritidis is known to have pathobiology specific to chickens that impacts epidemiology in humans. Therefore, more information is needed about S. Enteritidis pathobiology in comparison to that of S. Typhimurium. We used transposon mutagenesis to identify S. Enteritidis virulence genes by assay of invasiveness in human intestinal epithelial (Caco-2) cells and chicken liver (LMH) cells and survival within chicken (HD-11) macrophages as a surrogate marker for virulence. A total of 4,330 transposon insertion mutants of an invasive G1 Nalr strain were screened using Caco-2 cells. This led to the identification of attenuating mutations in a total of 33 different loci, many of which include genes previously known to contribute to enteric infection (e.g., Salmonella pathogenicity island 1 [SPI-1], SPI-4, SPI-5, CS54, fliH, fljB, csgB, spvR, and rfbMN) in S. Enteritidis and other Salmonella serovars. Several genes or genomic islands that have not been reported previously (e.g., SPI-14, ksgA, SEN0034, SEN2278, and SEN3503) or that are absent in S. Typhimurium or in most other Salmonella serovars (e.g., pegD, SEN1152, SEN1393, and SEN1966) were also identified. Most mutants with reduced Caco-2 cell invasiveness also showed significantly reduced invasiveness in chicken liver cells and impaired survival in chicken macrophages and in egg albumen. Consequently, these genes may play an important role during infection of the chicken host and also contribute to successful egg contamination by S. Enteritidis. PMID:22988017

Response evaluation after primary systemic therapy of Her2 positive breast cancer – an observational cross-sectional study.

PubMed

Tőkés, Tímea; Szentmártoni, Gyöngyvér; Torgyík, László; Kajáry, Kornélia; Lengyel, Zsolt; Györke, Tamás; Molnár, Béla Á; Tőkés, Anna-Mária; Kulka, Janina; Dank, Magdolna

2015-04-01

To evaluate (I) trastuzumab-containing primary systemic therapy (PST) in human epidermal growth factor receptor 2 (Her2) overexpressing breast carcinomas.; (II) compare the patients who achieved and those who did not achieve pathological complete remission (pCR), and (III) analyze the accuracy of different clinical-imaging modalities in tumor response monitoring. 188 patients who received PST between 2008 and 2014 were reviewed and 43 Her2 overexpressing breast cancer patients (28 Luminal B/Her2-positive and 15 Her2-positive) were enrolled. 26 patients received mostly taxane-based PST without trastuzumab (Group 1) and 17 patients received trastuzumab-containing PST (Group 2). We compared the concordance between pCR and complete remission (CR) defined by breast-ultrasound, CR defined by standard 18F-fluoro-deoxy-glucose positron emission tomography and computerized tomography (FDG-PET/CT) criteria (Method 1) and CR defined by a novel, breast cancer specific FDG-PET/CT criteria (Method 2). Sensitivity (sens), specificity (spec), and positive (PPV) and negative predictive values (NPV) were calculated. Ten patients (38.5%) in Group 1 and eight (47%) in Group 2 achieved pCR. pCR was significantly more frequent in Her2-positive than in Luminal B/Her2-positive tumors in both Group 1: (P=0.043) and Group 2: (P=0.029). PET/CT evaluated by the breast cancer specific criteria (Method 2) differentiated pCR from non-pCR more accurately in both groups (Group 1: sens=77.8%, spec=%, PPV=100%, NPV=71.4%; Group 2: sens=87.5%, spec=62.5%, PPV=70%, NPV=83.3%) than standard PET/CT criteria (Method 1) (Group 1: sens=22.2% spec=100% PPV=100% NPV=41.7%; in Group 2: sens=37.5%, spec=87.5%, PPV=75% NPV=58.3%) or breast ultrasound (Group 1, sens=83.3% spec=25% PPV=62.5% NPV=50%; Group 2, sens=100% spec=12.5% PPV=41.6% NPV=100%). The benefit of targeted treatment with trastuzumab-containing PST in Her2 overexpressing breast cancer was defined in terms of pCR rate. Luminal B/Her2-positive subtype needs further subdivision to identify patients who would benefit from PST. Combined evaluation of tumor response by our novel, breast cancer specific FDG-PET/CT criteria accurately differentiated pCR from non-pCR patients.

Multicenter Comparison of Roche COBAS AMPLICOR MONITOR Version 1.5, Organon Teknika NucliSens QT with Extractor, and Bayer Quantiplex Version 3.0 for Quantification of Human Immunodeficiency Virus Type 1 RNA in Plasma

PubMed Central

Murphy, Donald G.; Côté, Louise; Fauvel, Micheline; René, Pierre; Vincelette, Jean

2000-01-01

The performance and characteristics of Roche COBAS AMPLICOR HIV-1 MONITOR version 1.5 (CA MONITOR 1.5) UltraSensitive (usCA MONITOR 1.5) and Standard (stCA MONITOR 1.5) procedures, Organon Teknika NucliSens HIV-1 RNA QT with Extractor (NucliSens), and Bayer Quantiplex HIV RNA version 3.0 (bDNA 3.0) were compared in a multicenter trial. Samples used in this study included 460 plasma specimens from human immunodeficiency virus (HIV) type 1 (HIV-1)-infected persons, 100 plasma specimens from HIV antibody (anti-HIV)-negative persons, and culture supernatants of HIV-1 subtype A to E isolates diluted in anti-HIV-negative plasma. Overall, bDNA 3.0 showed the least variation in RNA measures upon repeat testing. For the Roche assays, usCA MONITOR 1.5 displayed less variation in RNA measures than stCA MONITOR 1.5. NucliSens, at an input volume of 2 ml, showed the best sensitivity. Deming regression analysis indicated that the results of all three assays were significantly correlated (P < 0.0001). However, the mean difference in values between CA MONITOR 1.5 and bDNA 3.0 (0.274 log10 RNA copies/ml; 95% confidence interval, 0.192 to 0.356) was significantly different from 0, indicating that CA MONITOR 1.5 values were regularly higher than bDNA 3.0 values. Upon testing of 100 anti-HIV-negative plasma specimens, usCA MONITOR 1.5 and NucliSens displayed 100% specificity, while bDNA 3.0 showed 98% specificity. NucliSens quantified 2 of 10 non-subtype B viral isolates at 1 log10 lower than both CA MONITOR 1.5 and bDNA 3.0. For NucliSens, testing of specimens with greater than 1,000 RNA copies/ml at input volumes of 0.1, 0.2, and 2.0 ml did not affect the quality of results. Additional factors differing between assays included specimen throughput and volume requirements, limit of detection, ease of execution, instrument work space, and costs of disposal. These characteristics, along with assay performance, should be considered when one is selecting a viral load assay. PMID:11060065

Dual Powerpoint Presentation Approach for Students with Special Educational Needs and Note-Takers

ERIC Educational Resources Information Center

Naik, Nitin

2017-01-01

In higher education, supporting students with special educational needs (SEN) necessitates an understanding of these needs, additional teaching aids and innovative ideas. The teacher must be an integral part of this support process, and this is difficult for the majority of teachers, due to their lack of core understanding of SEN. However,…

Community-Involved Learning to Expand Possibilities for Vulnerable Children: A Critical Communicative, Sen's Capability, and Action Research Approach

ERIC Educational Resources Information Center

Kim, Kyung Hi

2014-01-01

This research, based on a case study of vulnerable children in Korea, used a mixed methods transformative approach to explore strategies to support and help disadvantaged children. The methodological approach includes three phases: a mixed methods contextual analysis, a qualitative dominant analysis based on Sen's capability approach and critical…

How Will the Indian Military’s Upgrade and Modernization of Its ISR, Precision Strike, and Missile Defense Affect the Stability in South Asia?

DTIC Science & Technology

2005-03-01

September 2001), 2. 13 Amartya Sen and Jean Dreze. India: Economic Development and Social Opportunity. Oxford University Press, 1999, 1. 12...University Press, 2000), 261. Sen , Amartya and Jean Dreze. India: Economic Development and Social Opportunity. Oxford University Press, 1999

Development of the American Democracy Transnational Social Movement. Strategic Insights v4 n5 May 2005

DTIC Science & Technology

2005-05-01

increases."[5] In addition to this pacifying influence, democracies are better at providing for their citizens’ needs. Amartya Sen , the recipient of the...Russett and John Oneal, Triangulating Peace (New York: W.W. Norton & Company, Inc, 2001), 275. 6. Amartya Sen , "Democracy as a Universal Value" The

Sen and the Art of Motorcycle Maintenance: Adaptive Preferences and Higher Education

ERIC Educational Resources Information Center

Watts, Michael

2009-01-01

Adaptive preferences are both a central justification and continuing problem for the use of the capability approach. They are illustrated here with reference to a project examining the choices of young people who had rejected higher education. Jon Elster, Amartya Sen and Martha Nussbaum have all criticised utilitarianism on the grounds that a…

Disentangling the Circularity in Sen's Capability Approach: An Analysis of the Co-Evolution of Functioning Achievement and Resources

ERIC Educational Resources Information Center

Binder, Martin; Coad, Alex

2011-01-01

There is an ambiguity in Amartya Sen's capability approach as to what constitutes an individual's resources, conversion factors and valuable functionings. What we here call the "circularity problem" points to the fact that all three concepts seem to be mutually endogenous and interdependent. To econometrically account for this…

Understanding Indian Insurgencies: Implications for Counterinsurgency Operations in the Third World

DTIC Science & Technology

2007-02-01

Democracy, Amartya Sen pointed out how “a country does not have to be judged to be fit for democracy, rather it has to become fit through democracy...stage, has taken refuge in territory outside the contested area (e.g., Lenin in France and Austria, Sun Yat- Sen in Japan, Fidel Castro in Mexico, Che

Sen and the Art of Educational Maintenance: Evidencing a Capability, as Opposed to an Effectiveness, Approach to Schooling

ERIC Educational Resources Information Center

Kelly, Anthony

2012-01-01

There are few more widely applied terms in common parlance than "capability". It is used (inaccurately) to represent everything from the aspiration to provide opportunity to notions of innate academic ability, with everything in between claiming apostolic succession to Amartya Sen, who (with apologies to Aristotle) first developed the…

Hardiness of Adolescents with Special Educational Needs: Research Results

ERIC Educational Resources Information Center

Shchipanova, Dina Ye.; Tserkovnikova, Nataliya G.; Uskova, Bella A.; Puzyrev, Viktor V.; Markova, Anastasia S.; Fomin, Evgenii P.

2016-01-01

The relevance of the problem under study is due to the fact that the current worldwide trend shows high dynamics of the increase in the number of children with SEN, which requires that society in general and the education system, in particular, should develop approaches to the socialization and adaptation of people with SEN through strengthening…

Characteristics of Teacher-Identified Students with Special Educational Needs in Dutch Mainstream Primary Education

ERIC Educational Resources Information Center

Bruggink, M.; Goei, S. L.; Koot, H. M.

2013-01-01

Background: Traditionally, special educational needs (SEN) were often defined in terms of child deficits. Recently, there has been a tendency to define SEN in terms of (additional) support needed in the classroom. However, little is known about how teachers define students with special educational needs. To close this gap, characteristics of…

The Influence of Occupational Socialisation upon the Teaching of Pupils Experiencing Social and Emotional Behavioural Difficulties (SEBD) in Physical Education

ERIC Educational Resources Information Center

O'Leary, Nick; Longmore, Carl; Medcalf, Richard

2015-01-01

Research within physical education (PE) utilising the occupational socialisation framework indicates that the childhood phase of socialisation is the most powerful phase of socialisation. However, for most teachers working with pupils experiencing special educational needs (SEN), the childhood phase often lacks direct experience of SEN and thus…

Moderate Learning Difficulties: Searching for Clarity and Understanding

ERIC Educational Resources Information Center

Norwich, Brahm; Ylonen, Annamari; Gwernan-Jones, Ruth

2014-01-01

The concept of moderate learning difficulties (MLD) is not clearly understood in its definition and in its general use. Nevertheless, as a distinct area of special educational needs (SEN) this category has constituted about a quarter of all of those pupils identified as having SEN in England. This paper reports the analysis of findings from an…

Health-related quality of life research and the capability approach of Amartya Sen.

PubMed

Verkerk, M A; Busschbach, J J; Karssing, E D

2001-01-01

Standardised health-related quality of life questionnaires play an increasing role as measures of outcome in the evaluation of health care interventions. However, problems can arise when the selected functions or dimensions of such standardised measures are not in line with the intervention that is the focus of the research. Furthermore, the subjective element of quality of life makes standardised questionnaires vulnerable to the coping mechanism, thereby decreasing their sensitivity. The capability approach of the economist and philosopher Amartya Sen offers a descriptive concept that contributes to a better understanding of these problems. This article provides an introduction to the ideas of Sen for researchers who wish to go beyond the traditional framework of measuring health-related quality of life.

miR-Sens—a retroviral dual-luciferase reporter to detect microRNA activity in primary cells

PubMed Central

Beillard, Emmanuel; Ong, Siau Chi; Giannakakis, Antonis; Guccione, Ernesto; Vardy, Leah A.; Voorhoeve, P. Mathijs

2012-01-01

MicroRNA–mRNA interactions are commonly validated and deconstructed in cell lines transfected with luciferase reporters. However, due to cell type-specific variations in microRNA or RNA-binding protein abundance, such assays may not reliably reflect microRNA activity in other cell types that are less easily transfected. In order to measure miRNA activity in primary cells, we constructed miR-Sens, a MSCV-based retroviral vector that encodes both a Renilla luciferase reporter gene controlled by microRNA binding sites in its 3′ UTR and a Firefly luciferase normalization gene. miR-Sens sensors can be efficiently transduced in primary cells such as human fibroblasts and mammary epithelial cells, and allow the detection of overexpressed and, more importantly, endogenous microRNAs. Notably, we find that the relative luciferase activity is correlated to the miRNA expression, allowing quantitative measurement of microRNA activity. We have subsequently validated the miR-Sens 3′ UTR vectors with known human miRNA-372, miRNA-373, and miRNA-31 targets (LATS2 and TXNIP). Overall, we observe that miR-Sens-based assays are highly reproducible, allowing detection of the independent contribution of multiple microRNAs to 3′ UTR–mediated translational control of LATS2. In conclusion, miR-Sens is a new tool for the efficient study of microRNA activity in primary cells or panels of cell lines. This vector will not only be useful for studies on microRNA biology, but also more broadly on other factors influencing the translation of mRNAs. PMID:22417692

An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens.

PubMed

Saito, Kazutoshi; Takenouchi, Osamu; Nukada, Yuko; Miyazawa, Masaaki; Sakaguchi, Hitoshi

2017-04-01

To evaluate chemicals (e.g. lipophilic chemicals, pre/pro-haptens) that are difficult to correctly evaluate using in vitro skin sensitization tests (e.g. DPRA, KeratinoSens or h-CLAT), we developed a novel in vitro test termed "Epidermal Sensitization Assay: EpiSensA" that uses reconstructed human epidermis. This assay is based on the induction of multiple marker genes (ATF3, IL-8, DNAJB4 and GCLM) related to two keratinocyte responses (inflammatory or cytoprotective) in the induction of skin sensitization. Here, we first confirmed the mechanistic relevance of these marker genes by focusing on key molecules that regulate keratinocyte responses in vivo (P2X 7 for inflammatory and Nrf2 for cytoprotective responses). The up-regulation of ATF3 and IL-8, or DNAJB4 and GCLM induced by the representative sensitizer 2,4-dinitrochlorobenzene in human keratinocytes was significantly suppressed by a P2X 7 specific antagonist KN-62, or by Nrf2 siRNA, respectively, which supported mechanistic relevance of marker genes. Moreover, the EpiSensA had sensitivity, specificity and accuracy of 93%, 100% and 93% for 29 lipophilic chemicals (logKow≥3.5), and of 96%, 75% and 88% for 43 hydrophilic chemicals including 11 pre/pro-haptens, compared with the LLNA. These results suggested that the EpiSensA could be a mechanism-based test applicable to broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Copyright © 2016 Elsevier Ltd. All rights reserved.

Arctic Security in a Warming World

DTIC Science & Technology

2010-03-01

2009). 3 Map based on: “Northwest Passage - Map of Arctic Sea Ice: Global Warming is Opening Canada’s Arctic” http://geology.com/articles/northwest...War College, February 17, 2009) 3. 5 Scott G. Borgerson, “Arctic Meltdown: the Economic and Security Implications of Global Warming ”, Foreign Affairs...april/kirkpatrick.pdf (accessed February 10, 2010). 45 Thomas R. McCarthy, Jr., Global Warming Threatens National Interests in the Arctic, Strategy

Managing the Near Term Functions of Change in Medical Units.

DTIC Science & Technology

1986-06-06

BIBLIOGRAPHY Books Ackoff, Russell L. and Jamshid Gharajedaghi and Elsa Vergara Finnell. A Guide to Controlling Your Corporation’s Future. New York...Management In Transition. San Francisco : Jossey-Bass Publishers, 1985. 156 -. Havelock, Ronald G. and Mary C. Havelock. Training for Change Agents A...Jones-Irwin, 1984. Kirkpatrick, Donald L. How To Manage Change Effectively Approaches, Methods, and Case Examples. San Francisco : Jossey-Bass Inc

Parallel Algorithms for Computer Vision.

DTIC Science & Technology

1989-01-01

34 IEEE Tran. Pattern Ankyaij and Ma- Artifcial Intelligence , Tokyo, 1979. chine Intelligence , 6, 1984. Kirkpatrick, S., C.D. Gelatt, Jr. and M.P. Vecchi...MASSACHUSETTS INST OF TECH CAMBRIDGE ARTIFICIAL INTELLIGENCE LAB T P06010 JAN 89 ETL-0529 UNCLASSIFIED DACA76-85-C-0010 F.’G 12/1I N mommiimmmiiso...PoggioI Massachusetts Institute of Technology i Artificial Intelligence Laboratory 545 Technology Square Cambridge, Massachusetts 02139 DTIC January

Cosmic clustering

DOE PAGES

Anninos, Dionysios; Denef, Frederik

2016-06-30

We show that the late time Hartle-Hawking wave function for a free massless scalar in a fixed de Sitter background encodes a sharp ultrametric structure for the standard Euclidean distance on the space of field configurations. This implies a hierarchical, tree-like organization of the state space, reflecting its genesis as a branched diffusion process. In conclusion, an equivalent mathematical structure organizes the state space of the Sherrington-Kirkpatrick model of a spin glass.

Wind Noise Suppression for Infrasound Sensors

DTIC Science & Technology

2014-03-01

Wind Noise Suppression for Infrasound Sensors by John M. Noble, W.C. Kirkpatrick Alberts, II, Sandra L. Collier, Richard Raspet, and Mark A...Laboratory Adelphi, MD 20783-1197 ARL-TR-6873 March 2014 Wind Noise Suppression for Infrasound Sensors John M. Noble, Sandra L. Collier, and...DATES COVERED (From - To) October 2012 to September 2013 4. TITLE AND SUBTITLE Wind Noise Suppression for Infrasound Sensors 5a. CONTRACT NUMBER 5b

Focusing X-ray free-electron laser pulses using Kirkpatrick-Baez mirrors at the NCI hutch of the PAL-XFEL.

PubMed

Kim, Jangwoo; Kim, Hyo Yun; Park, Jaehyun; Kim, Sangsoo; Kim, Sunam; Rah, Seungyu; Lim, Jun; Nam, Ki Hyun

2018-01-01

The Pohang Accelerator Laboratory X-ray Free-Electron Laser (PAL-XFEL) is a recently commissioned X-ray free-electron laser (XFEL) facility that provides intense ultrashort X-ray pulses based on the self-amplified spontaneous emission process. The nano-crystallography and coherent imaging (NCI) hutch with forward-scattering geometry is located at the hard X-ray beamline of the PAL-XFEL and provides opportunities to perform serial femtosecond crystallography and coherent X-ray diffraction imaging. To produce intense high-density XFEL pulses at the interaction positions between the X-rays and various samples, a microfocusing Kirkpatrick-Baez (KB) mirror system that includes an ultra-precision manipulator has been developed. In this paper, the design of a KB mirror system that focuses the hard XFEL beam onto a fixed sample point of the NCI hutch, which is positioned along the hard XFEL beamline, is described. The focusing system produces a two-dimensional focusing beam at approximately 2 µm scale across the 2-11 keV photon energy range. XFEL pulses of 9.7 keV energy were successfully focused onto an area of size 1.94 µm × 2.08 µm FWHM.

A Question of Agency: Applying Sen's Theory of Human Capability to the Concept of Secondary School Student Career "Choice"

ERIC Educational Resources Information Center

Galliott, Natal'ya; Graham, Linda J.

2014-01-01

In this paper, we seek to operationalize Amartya Sen's concept of human capability to guide a scholarly investigation of student career choice capability. We begin by outlining factors affecting youth labour markets in Australia; a prosperous country that is affected by a "two-speed" national economy. We then examine recent government…

The More Things Change the More They Stay the Same? A Response to the Audit Commission's Report on Statutory Assessment and Statements of Special Education Needs.

ERIC Educational Resources Information Center

Florian, Lani

2002-01-01

This article addresses issues raised by the British Audit Commission's report on statutory assessment and Statements of Special Educational Needs (SEN). Questions are raised concerning ideas of "special educational needs,""areas of need," and "categories of handicap"; fair distribution of SEN funding; relationships…

Social Justice and the Philosophical Foundations of Critical Peace Education: Exploring Nussbaum, Sen, and Freire

ERIC Educational Resources Information Center

Snauwaert, Dale

2011-01-01

The purpose of this paper is to philosophically explore a "realization-focused" capabilities theory of social justice, as articulated by AmartyaSen and Martha Nussbaum, as foundational to a theory of critical peace education. Paulo Freire's philosophy of critical pedagogy has had and continues to have a profound influence on the theory and…

Special Teachers' Educational Responses in Supporting Students with Special Educational Needs (SEN) in the Domain of Social Skills Development

ERIC Educational Resources Information Center

Vlachou, Anastasia; Stavroussi, Panayiota; Didaskalou, Eleni

2016-01-01

The acquisition of appropriate social skills is considered critical for a person's social development and personal well-being. This consideration is far more crucial in the area of inclusive education, where the development of social skills in children with SEN has been associated with academic progress, social inclusion and successful transition…

Classroom Behaviour Management Strategies in Response to Problematic Behaviours of Primary School Children with Special Educational Needs: Views of Special Educational Needs Coordinators

ERIC Educational Resources Information Center

Nye, Elizabeth; Gardner, Frances; Hansford, Lorraine; Edwards, Vanessa; Hayes, Rachel; Ford, Tamsin

2016-01-01

Children identified with special educational needs (SEN) and behavioural difficulties present extra challenges to educators and require additional supports in school. This paper presents views from special educational needs coordinators (SENCos) on various strategies used by educators to support children identified with SEN and problematic…

Pedagogy for Ethnic Minority Pupils with Special Educational Needs in England: Common yet Different?

ERIC Educational Resources Information Center

Tan, Andrea Geok Poh; Ware, Jean; Norwich, Brahm

2017-01-01

The increasing ethnic diversity in the UK has highlighted the importance of supporting primary school pupils with English as an Additional Language (EAL), some of whom also have special educational needs (SEN). However, there is relatively little research carried out in the UK on children with both EAL needs and SEN. This paper presents the…

Parents' Involvement in Inclusive Education: An Empirical Test for the Psycho-Educational Development of Learners with Special Education Needs (SENs)

ERIC Educational Resources Information Center

Afolabi, Olusegun Emmanuel

2014-01-01

There is mounting evidence that involvement paradigm is a major strategy that supports positive learning outcomes and is critically vital for educating learners with special educational needs (SENs). To illuminate the parental involvement concept and potential in a concrete context, this paper explains 1) the empirical literature that explains the…

Staying on Task: Can a Thinking Skills Approach Support a Productive Pedagogy for Inclusion?

ERIC Educational Resources Information Center

Baumfield, Vivienne; Devlin, Niall

2005-01-01

This study investigates the effects of a thinking skills approach on the on task rates of pupils with Special Educational Needs (SEN). There were three situations: two experimental and one controlled. The experimental situations compared on task rates of 19 primary-aged pupils with SEN in thinking skills (TS) and non-thinking skills (XTS) lessons.…

Men in Limbo: Former Students with Special Educational Needs Caught between Economic Independence and Social Security Dependence

ERIC Educational Resources Information Center

Skjong, Gerd; Myklebust, Jon Olav

2016-01-01

Individuals in their mid-thirties are expected to be employed and economically independent. However, people with disabilities and health problems--for example, former students with special educational needs (SEN)--may have problems in this domain of adult life. In Norway, individuals with SEN frequently rely on social security and support measures…

Teaching Students with Special Educational Needs in Inclusive Music Classrooms: Experiences of Music Teachers in Hong Kong Primary Schools

ERIC Educational Resources Information Center

Wong, Marina Wai-yee; Chik, Maria Pik-yuk

2016-01-01

It has been a decade since the implementation of Hong Kong's policy of inclusion, that mainstream schools should admit students with special educational needs (SEN). This study reports on music teachers' experiences of teaching SEN students in inclusive music classrooms. Data were derived from a qualitative multiple case study comprising 10…

Glenn in his sleep rack on the Discovery's middeck

NASA Image and Video Library

1998-10-29

STS095-E-5032 (10-29-98) --- During Flight Day 1 activties, U.S. Sen. John H. Glenn Jr. takes part in his assigned medical studies as a payload specialist onboard the Space Shuttle Discovery. A flashlight floats in front of Sen. Glenn. The photo was made with an electronic still camera (ESC) at ll:48:35 GMT, Oct. 29.

OIG News Release: EPA IG responds to Sen. Vitter's letter about audit report on agency's use of private and alias email accounts to conduct official business

EPA Pesticide Factsheets

Arthur A. Elkins Jr., Inspector General for the U.S. Environmental Protection Agency, has replied to a letter signed and released to the public February 20 byU.S. Sen. David Vitter, Ranking Member of the Senate Committee on Environment and Public Works.

Teaching Assistants, Neuro-Linguistic Programming (NLP) and Special Educational Needs: "Reframing" the Learning Experience for Students with Mild SEN

ERIC Educational Resources Information Center

Kudliskis, Voldis

2014-01-01

This study examines how an understanding of two NLP concepts, the meta-model of language and the implementation of reframing, could be used to help teaching assistants enhance class-based interactions with students with mild SEN. Participants (students) completed a pre-intervention and a post-intervention "Beliefs About my Learning…

Competence Assessment of Students with Special Educational Needs--Identification of Appropriate Testing Accommodations

ERIC Educational Resources Information Center

Südkamp, Anna; Pohl, Steffi; Weinert, Sabine

2015-01-01

Including students with special educational needs in learning (SEN-L) is a challenge for large-scale assessments. In order to draw inferences with respect to students with SEN-L and to compare their scores to students in general education, one needs to assure that the measurement model is reliable and that the same construct is measured for…

Labelling and Self-Esteem: The Impact of Using Specific vs. Generic Labels

ERIC Educational Resources Information Center

Taylor, Laura Marie; Hume, Ian Robert; Welsh, Nikki

2010-01-01

The aim of this study is to investigate the relationship between being labelled either as having dyslexia or as having general special educational needs (SEN) and a child's self-esteem. Seventy-five children aged between 8 and 15 years categorised as having dyslexia (N = 26), as having general SEN (N = 26) or as having no learning difficulties (N…

The impact of speech and language problems in kindergarten on academic learning and special education status in grade three.

PubMed

Janus, Magdalena; Labonté, Chantal; Kirkpatrick, Ryan; Davies, Scott; Duku, Eric

2017-11-24

This study addressed the implications of experiencing early speech-language pathologies (SLPs) in kindergarten on special education needs (SEN) and academic outcomes in grade three. Early Development Instrument (EDI) kindergarten data on development and the presence or absence of SLPs were matched with grade three school-system standardised tests of reading, writing and maths, and SEN classification in Ontario, Canada for 59 015 students. Children were classified as having a Persistent speech language pathology (SLP), Remittent SLP, Latent SEN or as a typically developing Control. Even though 72.3% of children's SLPs remitted by grade three, kindergarten SLPs conveyed higher likelihood of having an SEN, and of lower achievement levels in grade three. The degree of impact varied between Persistent and Remittent groups. Children in the Latent group had lower scores in kindergarten on all five EDI domains than Control children. These population level results provide strong evidence to indicate that all children who present with an SLP in kindergarten face further academic challenges, even if their SLP resolves over time. Findings have implications for early intervention and treatment for children with early SLPs.

A novel technique using high energy synchronous double-wave laser in endoscopic submucosal dissection of patients with superficial esophageal neoplasm.

PubMed

Yao, Jun; Li, Jun; Wang, Peng; Liu, Feng; Li, Zhaoshen

2018-06-08

BACKGROUND : Endoscopic submucosal dissection (ESD) has been widely used to treat superficial esophageal neoplasms (SENs). Intraoperative bleeding is one of the main concerns that makes ESD in the esophagus more difficult and time consuming with higher complication rates. We introduced a novel laser endoknife system that enabled better intraoperative hemostasis, and preliminarily investigated its feasibility in ESD for patients with SENs.  17 consecutive patients with SENs were prospectively enrolled. The laser endoknife system was used in marking and submucosal dissection. Data on therapeutic outcomes were collected and analyzed.  The median diameter of the lesions was 2.5 cm and of the resected specimens was 3.0 cm. The median procedure time was 48 minutes. Histologic evaluation revealed 15 high grade intraepithelial neoplasias and two squamous cell carcinomas. No intraoperative bleeding occurred during laser cutting and no significant complications occurred postoperatively. Curative R0 resection was achieved in all patients.  Our new laser endoknife system was feasible in the submucosal dissection of SENs and showed great prospects for future application. © Georg Thieme Verlag KG Stuttgart · New York.

Prevalence of SENV-H and SENV-D virus: epidemiological study in blood donors and dialysis patients.

PubMed

Spataro, Pasquale; Di Pietro, Angela; Scoglio, Maria Elena; Visalli, Giuseppa; Chirico, Cristina; Picerno, Isa; Ferlazzo, Nadia; Campo, Salvatore; Bellinghieri, Guido; Savica, Vincenzo; Santoro, Domenico; Buemi, Michele; Costantino, Franco

2006-01-01

Recently, the identification of the SEN virus as a possible etiological agent of parental transmission hepatitis led to the study of the prevalence of such pathogen agents, particularly SENV-H, in our population. This paper compares the rate prevalence in high-risk subjects, such as dialysis patients, and low-risk subjects, such as blood donors. The study was carried out on SEN virus DNA extracted from serum of dialysis patients and blood donors, and the presence of viral genomes was performed by the nested PCR method. The results showed a higher prevalence in male blood donors, supporting the hypothesis of an epidemiological role for sexual and also parental transmission, as is clearly demonstrated by the high prevalence in dialysis patients. The result reduced the importance of the possible etiological role of the SEN virus due to the high percentage of positivity in healthy population, and it induces one to consider poorly significant the pathogenicity of such viral agents. For this instance, the authors, in agreement with the phylogenically related TT virus, described SEN viruses as absolutely not pathogens and considered them as "simple guests."

KSC-04PD-1563

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Sen. Bill Nelson (right), D-Fla., explains the layout of the glass cockpit to Sen. John F. Kerry, D-Mass., on the flight deck of orbiter Discovery during a tour of the Orbiter Processing Facility (OPF). The bunny suits they are wearing are clean room attire required for anyone coming in close proximity to Discovery, currently being prepared for flight on the next Space Shuttle mission. The tour of the OPF follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes Americas commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-04PD-1562

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Sen. John F. Kerry (left), D-Mass., and Sen. Bill Nelson, D-Fla., dressed in clean room attire, visit the flight deck of Space Shuttle Discovery during a tour of the Orbiter Processing Facility (OPF). The bunny suits are required dress for anyone coming in close proximity to Discovery, currently being prepared for flight on the next Space Shuttle mission. The tour of the OPF follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes Americas commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-04pd1562

NASA Image and Video Library

2004-07-26

KENNEDY SPACE CENTER, FLA. - Sen. John F. Kerry (left), D-Mass., and Sen. Bill Nelson, D-Fla., dressed in clean room attire, visit the flight deck of Space Shuttle Discovery during a tour of the Orbiter Processing Facility (OPF). The “bunny suits” are required dress for anyone coming in close proximity to Discovery, currently being prepared for flight on the next Space Shuttle mission. The tour of the OPF follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes America’s commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

The Effects of Type I Error Rate and Power of the ANCOVA F-Test and Selected Alternatives under Non-Normality and Variance Heterogeneity.

ERIC Educational Resources Information Center

Rheinheimer, David C.; Penfield, Douglas A.

The performance of analysis of covariance (ANCOVA) and six selected competitors was examined under varying experimental conditions through Monte Carlo simulations. The six alternatives were: (1) Quade's procedure (D. Quade, 1967); (2) Puri and Sen's solution (M. Puri and P. Sen, 1969); (3) Burnett and Barr's rank difference scores (T. Burnett and…

2014 Code of Practice: How Research Evidence on the Role and Impact of Teaching Assistants Can Inform Professional Practice

ERIC Educational Resources Information Center

Webster, Rob

2014-01-01

In this article, the author reflects on findings from research on the role and impact of teaching assistants and experience of working as a special educational needs (SEN) officer. Research evidence suggests the reliance on teaching assistants to include pupils with Statements of SEN in mainstream settings masks a collective, though unintentional,…

The British Government's Strategy for SEN: Implications for the Role and Future Development of Special Schools

ERIC Educational Resources Information Center

Baker, John

2007-01-01

In July 2006, the House of Commons Education and Skills Committee reported on Special Educational Needs. The report expressed concern over the Government's policy on SEN, especially as it relates to inclusion and to the confusion this has created for special schools. In this article I shall attempt to tease out what I believe to be the…

Segregation, Integration, Inclusion and Effective Provision: A Case Study of Perspectives from Special Educational Needs Children, Parents and Teachers in Bangalore India

ERIC Educational Resources Information Center

Elton-Chalcraft, Sally; Cammack, Paul J.; Harrison, Liz

2016-01-01

Educating special educational needs (SEN) children in special schools is the norm in India but there is a growing trend towards inclusive practice. Perspectives were sought from children, their parents and teachers in Bangalore, India to investigate perceptions of effective provision for SEN children using an interpretative approach to provide…

Researching and Developing Music Provision in Special Schools in England for Children and Young People with Complex Needs

ERIC Educational Resources Information Center

Cheng, Evangeline; Ockelford, Adam; Welch, Graham

2009-01-01

The House of Commons Select Committee on Education (2006) estimated that around 18% of all pupils in England were categorised as having Special Educational Needs (SEN). "Around 3% of all children (250,000) had a statement of SEN and around 1% of all children were in special schools (90,000) which represent approximately one third of children…

Parents' Perspective of the Impact of School Practices on the Functioning of Students with Special Educational Needs

ERIC Educational Resources Information Center

Lui, Ming; Yang, Lan; Sin, Kuen-Fung

2017-01-01

Students with special educational needs (SEN) are at an elevated risk of psychological and behavioural dysfunctions. In this study, we conducted a survey of parents of students with SEN in Hong Kong to examine the impact of two school practices--learning support and school climate--on the psychological and behavioural functioning (PBF) of students…

Meeting the Educational and Social Needs of Children with Language Impairment or Autism Spectrum Disorder: The Parents' Perspectives

ERIC Educational Resources Information Center

Lindsay, Geoff; Ricketts, Jessie; Peacey, Lindy V.; Dockrell, Julie E.; Charman, Tony

2016-01-01

Background: There is increasing interest in examining the perspectives of parents of children with special educational needs (SEN). Exploring the view of parents of a child with language impairment (LI) or autism spectrum disorder (ASD) is particularly important because of their high prevalence, at over 30% of children with SEN in England, and the…

East Asia: Southeast Asia

DTIC Science & Technology

1990-08-03

each grassroots unit is also wrong. Some of these mistakes are the presentation of erroneous issues for the benefit of mankind, seeking social impetus...board of directors of the Intersputnik organization permitted station Hoa Sen [ Lotus ] I to begin test operations. With the Hoa Sen I satellite...by his organization to mark Ho Chi Minh’s 100th birth centenary. (NHAN DAN 7 May 90 pp 1,4)

If GDP Is Not the Answer, What Is the Question? The Juncture of Capabilities, Institutions and Measurement in the Stiglitz-Sen-Fitoussi Report

ERIC Educational Resources Information Center

Tsai, Ming-Chang

2011-01-01

This review essay offers an institutional critique of the Stiglitz-Sen-Fitoussi Report. The notion of human capabilities and functionings advocated by the Report demonstrates an inspirational perspective to monitor human progress in quality of life (QoL). Several measurements the Report suggested remain inadequate. The personal diary techniques…

NASA Stennis hosts 2010 NASA Day at the Capitol.

NASA Technical Reports Server (NTRS)

2010-01-01

Astronaut Danny Olivas (center) speaks to members of the Mississippi Senate in chambers during NASA Day at the Capitol in Jackson on Jan. 6. Olivas was joined at the podium by Stennis Deputy Director Patrick Scheuermann (standing, l to r), Sen. David Baria, D-Bay St. Louis, and Sen. Billy Hewes, R-Gulfport. Baria and Hewes both are members of the Mississippi Senate Gulf Coast delegation.

Examining Key Issues Underlying the Audit Commission Reports on SEN Policy Paper 1 (5th Series)

ERIC Educational Resources Information Center

Norwich, Brahm; Beek, Chris; Richardson, Penny; Gray, Peter

2004-01-01

This book is the first publication in the fifth series of seminars organised by the SEN Policy Options Steering Group to examine policy issues to do with special educational needs. The aim of the seminar was to examine in depth several underlying issues raised by the recent Audit Commission Reports on special educational needs. The seminar…

Management of a rapidly growing peritoneal dialysis population at the First Affiliated Hospital of Sun Yat-sen University.

PubMed

Yu, Xueqing; Yang, Xiao; Huang, Naya

2014-06-01

Managing a rapidly growing peritoneal dialysis program with more than 1000 patients involves multiple challenges, labor constraints, logistics, and excessive geographic distance. This paper describes how Sun Yat-sen University, Guangzhou, China, manages those issues, while simultaneously improving quality of the care and, subsequently, clinical outcomes. Copyright © 2014 International Society for Peritoneal Dialysis.

An improved state-parameter analysis of ecosystem models using data assimilation

USGS Publications Warehouse

Chen, M.; Liu, S.; Tieszen, L.L.; Hollinger, D.Y.

2008-01-01

Much of the effort spent in developing data assimilation methods for carbon dynamics analysis has focused on estimating optimal values for either model parameters or state variables. The main weakness of estimating parameter values alone (i.e., without considering state variables) is that all errors from input, output, and model structure are attributed to model parameter uncertainties. On the other hand, the accuracy of estimating state variables may be lowered if the temporal evolution of parameter values is not incorporated. This research develops a smoothed ensemble Kalman filter (SEnKF) by combining ensemble Kalman filter with kernel smoothing technique. SEnKF has following characteristics: (1) to estimate simultaneously the model states and parameters through concatenating unknown parameters and state variables into a joint state vector; (2) to mitigate dramatic, sudden changes of parameter values in parameter sampling and parameter evolution process, and control narrowing of parameter variance which results in filter divergence through adjusting smoothing factor in kernel smoothing algorithm; (3) to assimilate recursively data into the model and thus detect possible time variation of parameters; and (4) to address properly various sources of uncertainties stemming from input, output and parameter uncertainties. The SEnKF is tested by assimilating observed fluxes of carbon dioxide and environmental driving factor data from an AmeriFlux forest station located near Howland, Maine, USA, into a partition eddy flux model. Our analysis demonstrates that model parameters, such as light use efficiency, respiration coefficients, minimum and optimum temperatures for photosynthetic activity, and others, are highly constrained by eddy flux data at daily-to-seasonal time scales. The SEnKF stabilizes parameter values quickly regardless of the initial values of the parameters. Potential ecosystem light use efficiency demonstrates a strong seasonality. Results show that the simultaneous parameter estimation procedure significantly improves model predictions. Results also show that the SEnKF can dramatically reduce the variance in state variables stemming from the uncertainty of parameters and driving variables. The SEnKF is a robust and effective algorithm in evaluating and developing ecosystem models and in improving the understanding and quantification of carbon cycle parameters and processes. ?? 2008 Elsevier B.V.

Performance of three commercial viral load assays, Versant human immunodeficiency virus type 1 (HIV-1) RNA bDNA v3.0, Cobas AmpliPrep/Cobas TaqMan HIV-1, and NucliSens HIV-1 EasyQ v1.2, testing HIV-1 non-B subtypes and recombinant variants.

PubMed

Holguín, Africa; López, Marisa; Molinero, Mar; Soriano, Vincent

2008-09-01

Monitoring antiretroviral therapy requires that human immunodeficiency virus type 1 (HIV-1) viremia assays are applicable to all distinct variants. This study evaluates the performance of three commercial viral load assays-Versant HIV-1 RNA bDNA v3.0, Cobas AmpliPrep/Cobas TaqMan HIV-1, and NucliSens HIV-1 EasyQ v1.2-in testing 83 plasma specimens from patients carrying HIV-1 non-B subtypes and recombinants previously defined by phylogenetic analysis of the pol gene. All 28 specimens from patients under treatment presented viremia values below the detection limit with the three methods. In the remaining 55 specimens from naive individuals viremia could not be detected in 32.7, 20, and 14.6% using the NucliSens, Versant, or TaqMan tests, respectively, suggesting potential viral load underestimation of some samples by all techniques. Only 32 (58.2%) samples from naive subjects were quantified by the three methods; the NucliSens test provided the highest HIV RNA values (mean, 4.87 log copies/ml), and the Versant test provided the lowest (mean, 4.16 log copies/ml). Viremia differences of greater than 1 log were seen in 8 (14.5%) of 55 specimens, occurring in 10.9, 7.3, and 5.4%, respectively, of the specimens in comparisons of Versant versus NucliSens, Versant versus TaqMan, and TaqMan versus NucliSens. Differences greater than 0.5 log, considered significant for clinicians, occurred in 45.5, 27.3, and 29% when the same assays were compared. Some HIV-1 strains, such as subtype G and CRF02_AG, showed more discrepancies in distinct quantification methods than others. In summary, an adequate design of primers and probes is needed for optimal quantitation of plasma HIV-RNA in non-B subtypes. Our data emphasize the need to use the same method for monitoring patients on therapy and also the convenience of HIV-1 subtyping.

Construction of Optimal-Path Maps for Homogeneous-Cost-Region Path-Planning Problems

DTIC Science & Technology

1989-09-01

of Artificial Inteligence , 9%,4. 24. Kirkpatrick, S., Gelatt Jr., C. D., and Vecchi, M. P., "Optinization by Sinmulated Ani- nealing", Science, Vol...studied in depth by researchers in such fields as artificial intelligence, robot;cs, and computa- tional geometry. Most methods require homogeneous...the results of the research. 10 U. L SLEVANT RESEARCH A. APPLICABLE CONCEPTS FROM ARTIFICIAL INTELLIGENCE 1. Search Methods One of the central

Information Processing in Mammalian Visual Cortex.

DTIC Science & Technology

1986-02-26

cortex (VI). We used contours from the same hemisphere that had previously been mapped by LeVay et al. (1985) using our standard manual procedure...hardware being constructed by engineer Herb Adams and the software developed by Dave Bilitch. The major system components include: 1) a rat head-holding...Edelman et al.), Neurosci. Res. Found., pp. 585-612. Kirkpatrick et al. (1983) Science 200: 671-680. LeVay , S., M. Connolly, J. Houde, and D. C. Van

Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.

PubMed

Alcantara, Luiz Carlos; Van Dooren, Sonia; Gonçalves, Marilda Souza; Kashima, Simone; Costa, Maria Cristina Ramos; Santos, Fred Luciano Neves; Bittencourt, Achilea Lisboa; Dourado, Inês; Filho, Antonio Andrade; Covas, Dimas Tadeu; Vandamme, Anne-Mieke; Galvão-Castro, Bernardo

2003-08-01

The city of Salvador, Bahia, Brazil, has sociodemographic characteristics similar to some African cities. Up to now, it has had the highest prevalence of human T-cell lymphotropic virus type I (HTLV-I) infection (1.74%) in the country. To investigate which strains of HTLV-I are circulating in Salvador, we studied isolates from 82 patients infected with HTLV-I: 19 from the general population, 21 from pregnant women, 16 from intravenous drug users, and 26 from patients and their family attending a neurologic clinic. Phylogenetic analysis from part of the LTR fragments showed that most of these isolates belonged to the Transcontinental subgroup of the Cosmopolitan subtype (HTLV-Ia). Only one sample from a pregnant woman was closely related to the Japanese subgroup, suggesting recent introduction of a Japanese HTLV-I lineage into Salvador. betaA-Globin haplotypes were examined in 34 infected individuals and found to be atypical, confirming the racial heterogeneity of this population. A total of 20 chromosomes were characterized as Central African Republic (CAR) haplotype (29.4%), 31 (45.6%) were characterized as Benin (BEN) haplotype, and 17 (25%) were characterized as Senegal (SEN) haplotype. Five patients' genotypes (14.7%) were CAR/CAR; 10 (29,4%), BEN/BEN; 9 (26.5%), CAR/BEN; 2 (5.9%), BEN/SEN; and 7 (20.6%), SEN/SEN. One patient's genotype (2.9%) was CAR/SEN. The betaA-globin haplotype distribution in Salvador is unusual compared with other Brazilian states. Our data support the hypothesis of multiple post-Columbian introductions of African HTLV-Ia strains in Salvador, Bahia, Brazil.

[Prevalence of Cardiovascular Risk Factors at The Population Level: A Comparison of Ambulatory Physician-Coded Claims Data With Clinical Data From A Population-Based Study].

PubMed

Angelow, Aniela; Reber, Katrin Christiane; Schmidt, Carsten Oliver; Baumeister, Sebastian Edgar; Chenot, Jean-Francois

2018-06-04

The study assesses the validity of ICD-10 coded cardiovascular risk factors in claims data using gold-standard measurements from a population-based study for arterial hypertension, diabetes, dyslipidemia, smoking and obesity as a reference. Data of 1941 participants (46 % male, mean age 58±13 years) of the Study of Health in Pomerania (SHIP) were linked to electronic medical records from the regional association of statutory health insurance physicians from 2008 to 2012 used for billing purposes. Clinical data from SHIP was used as a gold standard to assess the agreement with claims data for ICD-10 codes I10.- (arterial hypertension), E10.- to E14.- (diabetes mellitus), E78.- (dyslipidemia), F17.- (smoking) and E65.- to E68.- (obesity). A higher agreement between ICD-coded and clinical diagnosis was found for diabetes (sensitivity (sens) 84%, specificity (spec) 95%, positive predictive value (ppv) 80%) and hypertension (sens 72%, spec 93%, ppv 97%) and a low level of agreement for smoking (sens 18%, spec 99%, ppv 89%), obesity (sens 22%, spec 99%, ppv 99%) and dyslipidemia (sens 40%, spec 60%, ppv 70%). Depending on the investigated cardiovascular risk factor, medication, documented additional cardiovascular co-morbidities, age, sex and clinical severity were associated with the ICD-coded cardiovascular risk factor. The quality of ICD-coding in ambulatory care is highly variable for different cardiovascular risk factors and outcomes. Diagnoses were generally undercoded, but those relevant for billing were coded more frequently. Our results can be used to quantify errors in population-based estimates of prevalence based on claims data for the investigated cardiovascular risk factors. © Georg Thieme Verlag KG Stuttgart · New York.

Evaluation of the new AmpliSens multiplex real-time PCR assay for simultaneous detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis.

PubMed

Rumyantseva, Tatiana; Golparian, Daniel; Nilsson, Christian S; Johansson, Emma; Falk, My; Fredlund, Hans; Van Dam, Alje; Guschin, Alexander; Unemo, Magnus

2015-10-01

In this study, we performed an evaluation of the new CE-marked multiplex real-time AmpliSens N.gonorrhoeae/C.trachomatis/M.genitalium/T.vaginalis-MULTIPRIME-FRT PCR assay compared to APTIMA tests, i.e., APTIMA COMBO 2 assay, APTIMA Trichomonas vaginalis assay (FDA-approved), and two different APTIMA Mycoplasma genitalium assays (research use only; one of them only used for discrepancy analysis). Vaginal swabs (n = 209) and first-void urine (FVU) specimens from females (n = 498) and males (n = 554), consecutive attendees (n = 1261) at a dermatovenerological clinic in Sweden, were examined. The sensitivity of the AmpliSens PCR assay for detection of C. trachomatis (6.3% prevalence), M. genitalium (5.7% prevalence), N. gonorrhoeae (0.3% prevalence), and T. vaginalis (0.08% prevalence) was 97.5% (95% confidence interval (CI): 91.2-99.6%), 81.9% (95% CI: 70.7-89.7%), 100% (95% CI: 40.2-100%) and 100% (95% CI: 16.5-100%), respectively. The specificity of the AmpliSens PCR assay was 100% (95% CI: 99.6-100%) for all agents. The analytical sensitivity and specificity for N. gonorrhoeae detection was excellent, i.e., 55 international gonococcal strains detected and 135 isolates of 13 non-gonococcal Neisseria species were negative. In conclusion, the multiplex real-time AmpliSens N.gonorrhoeae/C.trachomatis/M.genitalium/T.vaginalis-MULTIPRIME-FRT PCR assay demonstrated high sensitivity and excellent specificity for the detection of C. trachomatis, N. gonorrhoeae, and T. vaginalis, and excellent specificity but suboptimal sensitivity for M. genitalium detection. © 2015 APMIS. Published by John Wiley & Sons Ltd.

Exon-Enriched Libraries Reveal Large Genic Differences Between Aedes aegypti from Senegal, West Africa, and Populations Outside Africa

PubMed Central

Dickson, Laura B.; Campbell, Corey L.; Juneja, Punita; Jiggins, Francis M.; Sylla, Massamba; Black, William C.

2016-01-01

Aedes aegypti is one of the most studied mosquito species, and the principal vector of several arboviruses pathogenic to humans. Recently failure to oviposit, low fecundity, and poor egg-to-adult survival were observed when Ae. aegypti from Senegal (SenAae) West Africa were crossed with Ae. aegypti (Aaa) from outside of Africa, and in SenAae intercrosses. Fluorescent in situ hybridization analyses indicated rearrangements on chromosome 1, and pericentric inversions on chromosomes 2 and 3. Herein, high throughput sequencing (HTS) of exon-enriched libraries was used to compare chromosome-wide genetic diversity among Aaa collections from rural Thailand and Mexico, a sylvatic collection from southeastern Senegal (PK10), and an urban collection from western Senegal (Kaolack). Sex-specific polymorphisms were analyzed in Thailand and PK10 to assess genetic differences between sexes. Expected heterozygosity was greatest in SenAae. FST distributions of 15,735 genes among all six pairwise comparisons of the four collections indicated that Mexican and Thailand collections are genetically similar, while FST distributions between PK10 and Kaolack were distinct. All four comparisons of SenAae with Aaa indicated extreme differentiation. FST was uniform between sexes across all chromosomes in Thailand, but were different, especially on the sex autosome 1, in PK10. These patterns correlate with the reproductive isolation noted earlier. We hypothesize that cryptic Ae. aegypti taxa may exist in West Africa, and the large genic differences between Aaa and SenAae detected in the present study have accumulated over a long period following the evolution of chromosome rearrangements in allopatric populations that subsequently cause reproductive isolation when these populations became sympatric. PMID:28007834

Down-regulation of FcεRI-mediated CD63 basophil response during short-term VIT determined venom-nonspecific desensitization.

PubMed

Čelesnik Smodiš, Nina; Šilar, Mira; Eržen, Renato; Rijavec, Matija; Košnik, Mitja; Korošec, Peter

2014-01-01

We recently showed a desensitization of FcεRI-mediated basophil response after short-term VIT. Our aim was to evaluate the allergen specificity of this desensitization. In 11 Hymenoptera-venom double positive subjects, basophil threshold sensitivity (CD-sens) to anti-FcεRI, honeybee, and Vespula venom was assessed at the beginning and just before the first maintenance dose (MD) of single ultra-rush VIT. In some patients we also monitored CD-sens to rApi m 1 and/or rVes v 5 or other co-sensitizations (i.e., grass pollen). In additional 7 patients, basophils were stripped and sensitized with house dust mite (HDM) IgEs at the same time points. We demonstrated a marked reduction of CD-sens to anti-FcεRI and VIT-specific venom before the first MD in all 18 subjects included. Furthermore, in 10 out of 11 double positive subjects, a significant and comparable decrease before the first MD was also evident for non-VIT venom; this nonspecific decrease was further supported by the opposite recombinant species-specific major allergen. In one subject with additional grass pollen allergy, a decrease of CD-sens to grass allergen was also demonstrated. Similarly, in 7 cases of patients with passively HDM-sensitized basophils, a significant reduction of CD-sens was also evident to de novo sensitized HDM allergen. Short-term VIT induced basophil desensitization to VIT-specific as well as to VIT-nonspecific venom. As opposed to long-term VIT, which induces venom-specific changes, the effect of short-term VIT seems to be venom-nonspecific.

Down-Regulation of FcεRI-Mediated CD63 Basophil Response during Short-Term VIT Determined Venom-Nonspecific Desensitization

PubMed Central

Čelesnik Smodiš, Nina; Šilar, Mira; Eržen, Renato; Rijavec, Matija; Košnik, Mitja; Korošec, Peter

2014-01-01

Background We recently showed a desensitization of FcεRI-mediated basophil response after short-term VIT. Our aim was to evaluate the allergen specificity of this desensitization. Methods In 11 Hymenoptera-venom double positive subjects, basophil threshold sensitivity (CD-sens) to anti-FcεRI, honeybee, and Vespula venom was assessed at the beginning and just before the first maintenance dose (MD) of single ultra-rush VIT. In some patients we also monitored CD-sens to rApi m 1 and/or rVes v 5 or other co-sensitizations (i.e., grass pollen). In additional 7 patients, basophils were stripped and sensitized with house dust mite (HDM) IgEs at the same time points. Results We demonstrated a marked reduction of CD-sens to anti-FcεRI and VIT-specific venom before the first MD in all 18 subjects included. Furthermore, in 10 out of 11 double positive subjects, a significant and comparable decrease before the first MD was also evident for non-VIT venom; this nonspecific decrease was further supported by the opposite recombinant species-specific major allergen. In one subject with additional grass pollen allergy, a decrease of CD-sens to grass allergen was also demonstrated. Similarly, in 7 cases of patients with passively HDM-sensitized basophils, a significant reduction of CD-sens was also evident to de novo sensitized HDM allergen. Conclusions Short-term VIT induced basophil desensitization to VIT-specific as well as to VIT-nonspecific venom. As opposed to long-term VIT, which induces venom-specific changes, the effect of short-term VIT seems to be venom-nonspecific. PMID:24733549

KSC-04pd1563

NASA Image and Video Library

2004-07-26

KENNEDY SPACE CENTER, FLA. - Sen. Bill Nelson (right), D-Fla., explains the layout of the glass cockpit to Sen. John F. Kerry, D-Mass., on the flight deck of orbiter Discovery during a tour of the Orbiter Processing Facility (OPF). The “bunny suits” they are wearing are clean room attire required for anyone coming in close proximity to Discovery, currently being prepared for flight on the next Space Shuttle mission. The tour of the OPF follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes America’s commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

Person-Centred Reviews and Transition: An Exploration of the Views of Students and Their Parents/Carers

ERIC Educational Resources Information Center

White, Julie; Rae, Tina

2016-01-01

The person-centred review (PCR) is a model for the review of a student's special educational needs (SEN) which places the young person and their family at the centre of the process. This mixed-methods, exploratory study investigated the views of 16 students with SEN aged between 10-11 years (Year 6) and 13-14 years (Year 9), and their…

The Efficacy of a Digital Mathematics Intervention for English Language Learners in U.S. High Schools: An Analysis Using Sen's Capabilities Approach

ERIC Educational Resources Information Center

Freeman, Barbara

2010-01-01

English language learners (ELLs) often find themselves marginalized with respect to learning mathematics in U.S. schools due, in part, to language barriers and gaps in prerequisite math knowledge and skills. The goal of this study was to use Sen's (1980, 1992, 1999) capabilities approach model as a lens through which to analyze the relationship…

Peridynamic Applications for Orthotropic Materials

DTIC Science & Technology

2012-09-26

test and a vibration excitation of a laminated beam. An SEN (single edge notch) test of a 0° laminated plate was simulated by peridynamics and the...computational results matched very well with published experimental results. Fracture initiation and crack path of laminated plates with different fiber...Dwivedi [1] modeled the propagation of single-edge notch (SEN) in 0° laminated plate using cohesizve zone method. Xu [2] and Hu [3] proposed a two

Asymptotic Methods Especially in Combustion.

DTIC Science & Technology

1981-11-01

1980.) Invited paper. 101. G.S.S. Ludford & Asok K. Sen: Burning rate maximum of a plane premixed flame. Proceedings of the Seventh International...Reactive Systems, ed. by J. Ray Bowen, N. Manson, Antoni K. Ompenheim, and R.I. Soloukhin.) 102. G.S.S. Ludford: Premixed cylindrical flames...106. Asok K. Sen & 0.S.S. Ludford: Effects of mass diffusion on the burning rate of non-4ilute mixtures. Proceedings of the Eighteenth Symposium

The New Special Educational Needs (SEN) Legislation in England and Implications for Services for Children and Young People with Social, Emotional and Behavioural Difficulties

ERIC Educational Resources Information Center

Norwich, Brahm; Eaton, Andrew

2015-01-01

This paper analyses the first significant change to Special Educational Needs (SEN) legislation in England for over a decade, a change that promises new approaches to identification and assessment, increased parental choice and enhanced pupil outcomes. The paper aims to examine to what extent this new framework can live up to its claims in the…

Quarrelsome Committees in U.S. Defense Acquisition: The KC-X Case

DTIC Science & Technology

2014-04-30

close to its original specifications in the RfP published on February 24, 2010. NG-EADS supporters were decidedly negative. Sen. Sessions ( R -AL...party. Thus, for example, the Boeing congressional delegation included Rep. Todd Tiahrt ( R -KS), along with the largely Democratic Washington State...delegation. The congressional EADS supporters included Sen. Jeff Sessions ( R -AL). And political figures stepped up to claim a major role in changing

Analytical study of a Kerr-Sen black hole and a charged massive scalar field

NASA Astrophysics Data System (ADS)

Bernard, Canisius

2017-11-01

It is reported that Kerr-Newman and Kerr-Sen black holes are unstable to perturbations of charged massive scalar field. In this paper, we study analytically the complex frequencies which characterize charged massive scalar fields in a near-extremal Kerr-Sen black hole. For near-extremal Kerr-Sen black holes and for charged massive scalar fields in the eikonal large-mass M ≫μ regime, where M is the mass of the black hole, and μ is the mass of the charged scalar field, we have obtained a simple expression for the dimensionless ratio ωI/(ωR-ωc) , where ωI and ωR are, respectively, the imaginary and real parts of the frequency of the modes, and ωc is the critical frequency for the onset of super-radiance. We have also found our expression is consistent with the result of Hod [Phys. Rev. D 94, 044036 (2016), 10.1103/PhysRevD.94.044036] for the case of a near-extremal Kerr-Newman black hole and the result of Zouros and Eardly [Ann. Phys. (N.Y.) 118, 139 (1979), 10.1016/0003-4916(79)90237-9] for the case of neutral scalar fields in the background of a near-extremal Kerr black hole.

Designing evaluation studies to optimally inform policy: what factors do policy-makers in China consider when making resource allocation decisions on healthcare worker training programmes?

PubMed

Wu, Shishi; Legido-Quigley, Helena; Spencer, Julia; Coker, Richard James; Khan, Mishal Sameer

2018-02-23

In light of the gap in evidence to inform future resource allocation decisions about healthcare provider (HCP) training in low- and middle-income countries (LMICs), and the considerable donor investments being made towards training interventions, evaluation studies that are optimally designed to inform local policy-makers are needed. The aim of our study is to understand what features of HCP training evaluation studies are important for decision-making by policy-makers in LMICs. We investigate the extent to which evaluations based on the widely used Kirkpatrick model - focusing on direct outcomes of training, namely reaction of trainees, learning, behaviour change and improvements in programmatic health indicators - align with policy-makers' evidence needs for resource allocation decisions. We use China as a case study where resource allocation decisions about potential scale-up (using domestic funding) are being made about an externally funded pilot HCP training programme. Qualitative data were collected from high-level officials involved in resource allocation at the national and provincial level in China through ten face-to-face, in-depth interviews and two focus group discussions consisting of ten participants each. Data were analysed manually using an interpretive thematic analysis approach. Our study indicates that Chinese officials not only consider information about the direct outcomes of a training programme, as captured in the Kirkpatrick model, but also need information on the resources required to implement the training, the wider or indirect impacts of training, and the sustainability and scalability to other settings within the country. In addition to considering findings presented in evaluation studies, we found that Chinese policy-makers pay close attention to whether the evaluations were robust and to the composition of the evaluation team. Our qualitative study indicates that training programme evaluations that focus narrowly on direct training outcomes may not provide sufficient information for policy-makers to make decisions on future training programmes. Based on our findings, we have developed an evidence-based framework, which incorporates but expands beyond the Kirkpatrick model, to provide conceptual and practical guidance that aids in the design of training programme evaluations better suited to meet the information needs of policy-makers and to inform policy decisions.

Reproductive Incompatibility Involving Senegalese Aedes aegypti (L) Is Associated with Chromosome Rearrangements

PubMed Central

Dickson, Laura B.; Sharakhova, Maria V.; Timoshevskiy, Vladimir A.; Fleming, Karen L.; Caspary, Alex; Sylla, Massamba; Black, William C.

2016-01-01

Aedes aegypti, the primary vector of dengue, yellow fever and Zika flaviviruses, consists of at least two subspecies. Aedes aegypti (Aaa) is light in color, has pale scales on the first abdominal tergite, oviposits in artificial containers, and preferentially feeds on humans. Aedes aegypti formosus (Aaf), has a dark cuticle, is restricted to sub-Saharan Africa, has no pale scales on the first abdominal tergite and frequently oviposits in natural containers. Scale patterns correlate with cuticle color in East Africa but not in Senegal, West Africa where black cuticle mosquitoes display a continuum of scaling patterns and breed domestically indoors. An earlier laboratory study did not indicate any pre- or postzygotic barriers to gene flow between Aaa and Aaf in East Africa. However, similar attempts to construct F1 intercross families between Aaa laboratory strains and Senegal Ae. aegypti (SenAae) failed due to poor F1 oviposition and low F2 egg-to-adult survival. Insemination and assortative mating experiments failed to identify prezygotic mating barriers. Backcrosses were performed to test for postzygotic isolation patterns consistent with Haldane’s rule modified for species, like Aedes, that have an autosomal sex determining locus (SDL). Egg-pupal survival was predicted to be low in females mated to hybrid F1 males but average when a male mates with a hybrid F1 female. Survival was in fact significantly reduced when females mated to hybrid males but egg-pupal survival was significantly increased when males were mated to hybrid F1 females. These observations are therefore inconclusive with regards to Haldane’s rule. Basic cytogenetic analyses and Fluorescent In Situ Hybridization (FISH) experiments were performed to compare SenAae strains with the IB12 strain of Aaa that was used for genome sequencing and physical mapping. Some SenAae strains had longer chromosomes than IB12 and significantly different centromeric indices on chromosomes 1 and 3. DAPI staining was used to identify AT-rich regions, chromomycin A3 following pretreatment with barium hydroxide stained for GC-rich regions and stained the ribosomal RNA locus and YOYO-1 was used to test for differential staining. Chromosome patterns in SenAae strains revealed by these three stains differed from those in IB12. For FISH, 40 BAC clones previously physically mapped on Aaa chromosomes were used to test for chromosome rearrangements in SenAae relative to IB12. Differences in the order of markers identified two chromosomal rearrangements between IB12 and SenAae strains. The first rearrangement involves two overlapping pericentric (containing the centromere) inversions in chromosome 3 or an insertion of a large fragment into the 3q arm. The second rearrangement is close to the centromere on the p arm of chromosome 2. Linkage analysis of the SDL and the white-eye locus identified a likely chromosomal rearrangement on chromosome 1. The reproductive incompatibility observed within SenAae and between SenAae and Aaa may be generally associated with chromosome rearrangements on all three chromosomes and specifically caused by pericentric inversions on chromosomes 2 and 3. PMID:27105225

Integrating Intelligence and Acquisition to Meet Evolving Threats: Interview With Dr. Sean Kirkpatrick of the Defense Intelligence Agency

DTIC Science & Technology

2015-06-01

CIPs ) We have drafted policy language that Defense Acquisition, Technology, and Logistics now is coordinating that will make it a requirement for at...least Acquisition Category I programs to identify CIPs early and for the intelligence community to monitor those and report breaches throughout the...are coming. Two important ones are the Critical Intelligence Parameters ( CIPs ) policy and the change to the System Threat Assessment Re- port (STAR

OPERATION COBRA. Deliberate Attack, Exploitation

DTIC Science & Technology

1984-05-25

to attack Sens, then continue to Troyes , on the Seine River. CCA was in the north, crossing the Loing River at Souppes against light resistance and...advanced from Troyes and prepared positions close to Sens. Under strong artillery support, a task force from CCA (TF Oden) attacked the enemy frontally...movement towards the Seine River on 24 August with an advance toward Troyes . Facing the combat command were what remained of the 51st SS Brigade, light

SensInDenT-Noncontact Sensors Integrated Into Dental Treatment Units.

PubMed

Teichmann, Daniel; Teichmann, Maren; Weitz, Philippe; Wolfart, Stefan; Leonhardt, Steffen; Walter, Marian

2017-02-01

This paper presents the first system design (SensInDenT) for noncontact cardiorespiratory monitoring during dental treatment. The system is integrated into a dental treatment unit, and combines sensors based on electromagnetic, optical, and mechanical coupling at different sensor locations. The measurement principles and circuits are described and a system overview is presented. Furthermore, a first proof of concept is provided by taking measurements in healthy volunteers under laboratory conditions.

Design and evaluation of an IPE module at the beginning of professional training in medicine, nursing, and physiotherapy.

PubMed

Zirn, Lena; Körner, Mirjam; Luzay, Leonie; Sandeck, Florian; Müller-Fröhlich, Christa; Straub, Christine; Stößel, Ulrich; Silbernagel, Waltraud; Fischer, Julia

2016-01-01

Interprofessional education (IPE) is a central feature of modern education in the health care professions. Despite this, empirically founded and systematically structured IPE courses are absent from many curricula. To answer the WHO's call for improved interprofessional collaboration in the health care system, a seminar was designed, implemented and evaluated. The target group consisted of students beginning nursing and medical studies (first and second semesters) and physiotherapy students (first year of training). The aim was to develop a basic IPE module focusing not only on the demands placed by academia and politics, but also the interests of the target group. This module was evaluated on the basis of the modified four-level Kirkpatrick approach. Based on focus group interviews analyzed qualitatively using Mayring's content analysis, it was possible to define five learning objectives and develop four practice-oriented modules. The seminar was then implemented and evaluated using written pre- and post-seminar evaluations and group discussions. Analysis confirmed the success of the IPE concept in that the seminar was positively rated by attendees not only in terms of their immediate reactions, but also attitude, knowledge and skills according to Kirkpatrick. In the future, it is intended to offer the IPE module on a permanent basis and assess the competencies acquired in the seminar using observation. Courses to ensure sustained learning outcomes would also be desirable.

Evaluation of a continuing professional development training program for physicians and physician assistants in hospitals in Laos based on the Kirkpatrick model

PubMed Central

2016-01-01

Purpose: Medical professionals from Korea and Laos have been working together to develop a continuing professional development training program covering the major clinical fields of primary care. This study aimed to evaluate the effectiveness of the program from 2013 to 2014 using the Kirkpatrick model. Methods: A questionnaire was used to evaluate the reaction of the trainees, and the trainers assessed the level of trainees’ performance at the beginning and the end of each clinical section. The transfer (behavioral change) of the trainees was evaluated through the review of medical records written by the trainees before and after the training program. Results: The trainees were satisfied with the training program, for which the average score was 4.48 out of 5.0. The average score of the trainees’ performance at the beginning was 2.39 out of 5.0, and rose to 3.88 at the end of each section. The average score of the medical records written before the training was 2.92 out of 5.0, and it rose to 3.34 after the training. The number of patient visits to the district hospitals increased. Conclusion: The continuing professional development training program, which was planned and implemented with the full engagement and responsibility of Lao health professionals, proved to be effective. PMID:27246494

Kirkpatrick-Baez microscope for hard X-ray imaging of fast ignition experiments.

PubMed

Friesen, H; Tiedje, H F; Hey, D S; Mo, M Z; Beaudry, A; Fedosejevs, R; Tsui, Y Y; Mackinnon, A; McLean, H S; Patel, P K

2013-02-01

A Kirkpatrick-Baez X-ray microscope has been developed for use on the Titan laser facility at the Lawrence Livermore National Laboratory in Fast Ignition experiments. It was developed as a broadband alternative to narrow band Bragg crystal imagers for imaging Kα emission from tracer layers. A re-entrant design is employed which allows for alignment from outside the chamber. The mirrors are coated with Pt and operate at a grazing incident angle of 0.5° providing higher resolution than an equal brightness pinhole and sufficient bandwidth to image thermally shifted characteristic Kα emission from heated Cu tracer layers in Fast Ignition experiments. The superpolished substrates (<1 Å rms roughness) had a final visible wavelength roughness of 1.7 Å after coating, and exhibited a reflectivity corresponding to an X-ray wavelength roughness of 7 ± 1 Å. A unique feature of this design is that during experiments, the unfiltered direct signal along with the one-dimensional reflections are retained on the detector in order to enable a live indication of alignment and incident angle. The broad spectral window from 4 to 9 keV enables simultaneous observation of emission from several spectral regions of interest, which has been demonstrated to be particularly useful for cone-wire targets. An experimentally measured resolution of 15 μm has been obtained at the center of the field of view.

The National Ignition Facility modular Kirkpatrick-Baez microscope

DOE PAGES

Pickworth, L. A.; Ayers, J.; Bell, P.; ...

2016-08-10

Current two-dimensional X-ray imaging at the National Ignition Facility (NIF) uses time resolved pinhole cameras with ~10-25µm pinholes. This method has limitations in the smallest resolvable features that can be imaged with reasonable photon statistics for inertial confinement fusion (ICF) applications. ICF sources have a broadband self-emission spectrum that causes the pinhole images obtained, through thin foil filters, to contain a similarly broadband spectrum complicating the interpretation of structure in the source. In order to study phenomena on the scale of ~5 µm, such as dopant mix in the ICF capsule, a narrow energy band, higher spatial resolution microscope systemmore » with improved signal/noise has been developed using X-ray optics. Utilizing grazing incidence mirrors in a Kirkpatrick-Baez microscope (KBM) configuration, an X-ray microscope has been designed and fielded on NIF with four imaging channels. The KBM has ~12x magnification, <8 µm resolution and higher throughput in comparison to similar pinhole systems. The first KBM mirrors are coated with a multilayer mirror to allow a ‘narrow band’ energy response at 10.2keV with ΔE~3keV. By adjusting the mirror coating only, the energy response can be matched to future experimental requirements. Here, several mirror packs have been commissioned and are interchangeable in the diagnostic snout.« less

The National Ignition Facility modular Kirkpatrick-Baez microscope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pickworth, L. A.; Ayers, J.; Bell, P.

Current two-dimensional X-ray imaging at the National Ignition Facility (NIF) uses time resolved pinhole cameras with ~10-25µm pinholes. This method has limitations in the smallest resolvable features that can be imaged with reasonable photon statistics for inertial confinement fusion (ICF) applications. ICF sources have a broadband self-emission spectrum that causes the pinhole images obtained, through thin foil filters, to contain a similarly broadband spectrum complicating the interpretation of structure in the source. In order to study phenomena on the scale of ~5 µm, such as dopant mix in the ICF capsule, a narrow energy band, higher spatial resolution microscope systemmore » with improved signal/noise has been developed using X-ray optics. Utilizing grazing incidence mirrors in a Kirkpatrick-Baez microscope (KBM) configuration, an X-ray microscope has been designed and fielded on NIF with four imaging channels. The KBM has ~12x magnification, <8 µm resolution and higher throughput in comparison to similar pinhole systems. The first KBM mirrors are coated with a multilayer mirror to allow a ‘narrow band’ energy response at 10.2keV with ΔE~3keV. By adjusting the mirror coating only, the energy response can be matched to future experimental requirements. Here, several mirror packs have been commissioned and are interchangeable in the diagnostic snout.« less

Poppies for medicine in Afghanistan: lessons from India and Turkey.

PubMed

Windle, James

2011-01-01

This study examines India and Turkey as case studies relevant to the Senlis Council’s ‘poppies for medicine’ proposal. The proposal is that Afghan farmers are licensed to produce opium for medical and scientific purposes. Here it is posited that the Senlis proposal neglects at least three key lessons from the Turkish and Indian experiences. First, not enough weight has been given to diversion from licit markets, as experienced in India. Second, both India and Turkey had significantly more efficient state institutions with authority over the licensed growing areas. Third, the proposal appears to overlook the fact that Turkey’s successful transition was largely due to the use of the poppy straw method of opium production. It is concluded that, while innovative and creative policy proposals such as that of the Senlis proposal are required if Afghanistan is to move beyond its present problems, ‘poppies for medicine’ does not withstand evidence-based scrutiny.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perras, Frederic A.; Wang, Lin-Lin; Manzano, J. Sebastian

The efficacy of dynamic nuclear polarization (DNP) surface-enhanced NMR spectroscopy (SENS) is reviewed for alumina, silica, and ordered mesoporous carbon (OMC) materials, with vastly different surface areas, as a function of the biradical concentration. Importantly, our studies show that the use of a “one-size-fits-all” biradical concentration should be avoided when performing DNP SENS experiments and instead an optimal concentration should be selected as appropriate for the type of material studied as well as its surface area. In general, materials with greater surface areas require higher radical concentrations for best possible DNP performance. This result is explained with the use ofmore » a thermodynamic model wherein radical-surface interactions are expected to lead to an increase in the local concentration of the polarizing agent at the surface. We also show, using plane-wave density functional theory calculations, that weak radical-surface interactions are the cause of the poor performance of DNP SENS for carbonaceous materials.« less

Improving the accuracy of synovial fluid analysis in the diagnosis of prosthetic joint infection with simple and inexpensive biomarkers: C-reactive protein and adenosine deaminase.

PubMed

Sousa, R; Serrano, P; Gomes Dias, J; Oliveira, J C; Oliveira, A

2017-03-01

The aims of this study were to increase the diagnostic accuracy of the analysis of synovial fluid in the differentiation of prosthetic joint infection (PJI) by the addition of inexpensive biomarkers such as the levels of C-reactive protein (CRP), adenosine deaminase (ADA), alpha-2-macrogloblulin (α2M) and procalcitonin. Between January 2013 and December 2015, synovial fluid and removed implants were requested from 143 revision total joint arthroplasties. A total of 55 patients met inclusion criteria of the receipt of sufficient synovial fluid, tissue samples and removed implants for analysis. The diagnosis of PJI followed the definition from a recent International Consensus Meeting to create two groups of patients; septic and aseptic. Using receiver operating characteristic curves we determined the cutoff values and diagnostic accuracy for each marker. There were 23 PJIs and 32 patients with aseptic loosening. The levels of total leucocyte count, proportion of polymorphonuclear leucocytes (PMNs), CRP, ADA and α2M in the synovial fluid were all significantly higher in those with a PJI than in those with aseptic loosening. The levels of procalcitonin were comparable in the two groups. Cutoff values for the optimal performance in the diagnosis of infection were: total leucocyte count > 1463 cells/μL (sensitivity (Sens) 100%, specificity (Spec) 71.9%, positive predictive value (PPV) 71.9%, negative predictive value (NPV) 100%); proportion of PMNs > 81% (Sens 78.3%, Spec 75.0%, PPV 69.2%, NPV 82.8%); CRP > 6.7mg/L (Sens 78.3%, Spec 93.8%, PPV 90.0%, NPV 85.7%); ADA > 61U/L (Sens 78.3%, Spec 96.9%, PPV 94.7%, NPV 86.1%) and α2M > 958 mg/L (Sens 47.8%, Spec 96.9%, PPV 91.7%, NPV 72.1%). The addition of a raised level of CRP or ADA to the total leukocyte count increased the specificity: total leukocyte count > 1463 cells/μL and CRP > 6.7mg/L (Sens 78.3%, Spec 100%, PPV 100%, NPV 86.5%) or with ADA > 61U/L (Sens 78.3%, Spec 96.9%, PPV 94.7%, NPV 86.1%). The total leucocyte count in the synovial fluid offers great negative predictive value in the diagnosis of PJI and the addition of more specific markers such as CRP and ADA improves the positive predictive value. Thus the addition of simple and inexpensive markers to the measurement of the leucocyte count in the synovial fluid may reduce the number of equivocal results which demand more expensive investigation. Cite this article: Bone Joint J 2017;99-B:351-7. ©2017 The British Editorial Society of Bone & Joint Surgery.

Noninvasive Tests Do Not Accurately Differentiate Nonalcoholic Steatohepatitis From Simple Steatosis: A Systematic Review and Meta-analysis.

PubMed

Verhaegh, Pauline; Bavalia, Roisin; Winkens, Bjorn; Masclee, Ad; Jonkers, Daisy; Koek, Ger

2018-06-01

Nonalcoholic fatty liver disease is a rapidly increasing health problem. Liver biopsy analysis is the most sensitive test to differentiate between nonalcoholic steatohepatitis (NASH) and simple steatosis (SS), but noninvasive methods are needed. We performed a systematic review and meta-analysis of noninvasive tests for differentiating NASH from SS, focusing on blood markers. We performed a systematic search of the PubMed, Medline and Embase (1990-2016) databases using defined keywords, limited to full-text papers in English and human adults, and identified 2608 articles. Two independent reviewers screened the articles and identified 122 eligible articles that used liver biopsy as reference standard. If at least 2 studies were available, pooled sensitivity (sens p ) and specificity (spec p ) values were determined using the Meta-Analysis Package for R (metafor). In the 122 studies analyzed, 219 different blood markers (107 single markers and 112 scoring systems) were identified to differentiate NASH from simple steatosis, and 22 other diagnostic tests were studied. Markers identified related to several pathophysiological mechanisms. The markers analyzed in the largest proportions of studies were alanine aminotransferase (sens p , 63.5% and spec p , 74.4%) within routine biochemical tests, adiponectin (sensp, 72.0% and spec p , 75.7%) within inflammatory markers, CK18-M30 (sens p , 68.4% and spec p , 74.2%) within markers of cell death or proliferation and homeostatic model assessment of insulin resistance (sens p , 69.0% and spec p , 72.7%) within the metabolic markers. Two scoring systems could also be pooled: the NASH test (differentiated NASH from borderline NASH plus simple steatosis with 22.9% sens p and 95.3% spec p ) and the GlycoNASH test (67.1% sens p and 63.8% spec p ). In the meta-analysis, we found no test to differentiate NASH from SS with a high level of pooled sensitivity and specificity (≥80%). However, some blood markers, when included in scoring systems in single studies, identified patients with NASH with ≥80% sensitivity and specificity. Replication studies and more standardized study designs are urgently needed. At present, no marker or scoring system can be recommended for use in clinical practice to differentiate NASH from simple steatosis. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

Deconstruction of Oncogenic K-RAS Signaling Reveals Focal Adhesion Kinase as a Novel Therapeutic Target in NSCLC

DTIC Science & Technology

2015-10-01

Tang (Associate Professor at Sun Yat-sen University, Guangzhou, China , Visiting professor) and Niranjan Venkateswaran, MS (Research technician...supported by the Sun Yat-sen University, Guangzhou, China . Name: Niranjan Venkateswaran Project Role: Research technician II Researcher Identifier (e.g...Dallas,  TX.   Honors   1989   Medicina   Prize   for   Italian   Researchers   younger   than   35   years   of   age

Separated Component-Based Restoration of Speckled SAR Images

DTIC Science & Technology

2013-01-01

unsupervised change detection from SAR amplitude imagery,” IEEE Trans. Geosci. Remote Sens., vol. 44, no. 10, pp. 2972–2982, Oct. 2006. [5] F. Argenti , T...Sens., vol. 40, no. 10, pp. 2196–2212, Oct. 2002. [13] F. Argenti and L. Alparone, “Speckle removal from SAR images in the undecimated wavelet domain...iterative thresh- olding algorithm for linear inverse problems with a sparsity con- straint,” Commun . Pure Appl. Math., vol. 57, no. 11, pp. 1413

The relevance of basophil allergen sensitivity testing to distinguish between severe and mild peanut-allergic children.

PubMed

Homšak, Matjaž; Silar, Mira; Berce, Vojko; Tomazin, Maja; Skerbinjek-Kavalar, Maja; Celesnik, Nina; Košnik, Mitja; Korošec, Peter

2013-01-01

Peanut sensitization is common in children. However, it is difficult to assess which children will react mildly and which severely. This study evaluated the relevance of basophil allergen sensitivity testing to distinguish the severity of peanut allergy in children. Twenty-seven peanut-sensitized children with symptoms varying from mild symptoms to severe anaphylaxis underwent peanut CD63 dose-response curve analysis with the inclusion of basophil allergen sensitivity calculation (CD-sens) and peanut component immunoglobulin E (IgE) testing. Eleven children who had experienced anaphylaxis to peanuts showed a markedly higher peanut CD63 response at submaximal allergen concentrations and CD-sens (median 1,667 vs. 0.5; p < 0.0001) than 16 children who experienced a milder reaction. Furthermore, a negative or low CD-sens to peanuts unambiguously excluded anaphylactic peanut allergy. Children with anaphylaxis have higher levels of Ara h 1, 2, 3 and 9 IgE, but comparable levels of IgE to Ara h 8 and whole-peanut extract. The diagnostic specificity calculated with a receiver operating characteristic analysis reached 100% for CD-sens and 73% for Ara h 2. We demonstrated that severe peanut allergy is significantly associated with higher basophil allergen sensitivity. This cellular test should facilitate a more accurate diagnosis of peanut allergy. © 2013 S. Karger AG, Basel.

Effect of Drying Temperature on Rosmarinic Acid and Sinensetin Concentration in Orthosiphon stamineus Herbal Leaves

NASA Astrophysics Data System (ADS)

Abdullah, Sriyana; Razak Shaari, Abdul; Hajar Rukunudin, Ibni; Syarhabil Ahmad, Muhammad

2018-03-01

The objective of this work was to investigate the effects of drying temperature on the concentration of O rthosiphon stamineus biomarker compounds which were rosmarinic acid (RA) and sinensetin (SEN). The thin layer drying approach was used to dry O. stamineus leaves at various temperatures of 30, 40 and 50°C using a laboratory scale hot air dryer. The dried leaves were then extracted using 60% aqueous methanol prior to quantification. The RA and SEN concentrations in the dried leaves extracts were quantified by the high performance liquid chromatography. The concentration of RA for the dried leaves at 30 and 40°C were higher as compared to that of the fresh leaves. This may due to the response of the plant cells to abiotic stress. The concentration of RA also showed a significant reduction when the temperature was increased to 50°C. In contrast, the SEN concentration in O. stamineus dried leaf extract was lower than that of the fresh samples. The concentrations of SEN depicted insignificant effects by drying at 30 and 50°C, and the highest value was obtained in the samples dried at 40°C. Results showed that the drying process was found to affect the concentration of both compounds; therefore suitable drying conditions should be adopted to enhance the medicinal values of the plant species.

The COP9 Signalosome Converts Temporal Hormone Signaling to Spatial Restriction on Neural Competence

PubMed Central

Huang, Yi-Chun; Lu, Yu-Nung; Wu, June-Tai; Chien, Cheng-Ting; Pi, Haiwei

2014-01-01

During development, neural competence is conferred and maintained by integrating spatial and temporal regulations. The Drosophila sensory bristles that detect mechanical and chemical stimulations are arranged in stereotypical positions. The anterior wing margin (AWM) is arrayed with neuron-innervated sensory bristles, while posterior wing margin (PWM) bristles are non-innervated. We found that the COP9 signalosome (CSN) suppresses the neural competence of non-innervated bristles at the PWM. In CSN mutants, PWM bristles are transformed into neuron-innervated, which is attributed to sustained expression of the neural-determining factor Senseless (Sens). The CSN suppresses Sens through repression of the ecdysone signaling target gene broad (br) that encodes the BR-Z1 transcription factor to activate sens expression. Strikingly, CSN suppression of BR-Z1 is initiated at the prepupa-to-pupa transition, leading to Sens downregulation, and termination of the neural competence of PWM bristles. The role of ecdysone signaling to repress br after the prepupa-to-pupa transition is distinct from its conventional role in activation, and requires CSN deneddylating activity and multiple cullins, the major substrates of deneddylation. Several CSN subunits physically associate with ecdysone receptors to represses br at the transcriptional level. We propose a model in which nuclear hormone receptors cooperate with the deneddylation machinery to temporally shutdown downstream target gene expression, conferring a spatial restriction on neural competence at the PWM. PMID:25393278

History of the Joint Chiefs of Staff. Volume 5. The Joint Chiefs of Staff and National Policy, 1953-1954

DTIC Science & Technology

1986-01-01

Kirkpatrick, USN, CJCS Staff Group, "NATO Force Goals Attained 1951 through 1954 and Projections through 1957," 4 Mar 55, OQCS File 092.2 NATO 1955 319...CINCAL CINCARIB CINCCENTER CINCFE CINCLANT CINCNE CINCNELM CINCONAD CINCPAC CINCSOUTH CINCUNC CINCUSAFE CINCUSAREUR CJCS COMLANDCENT...Snyder, "New Look," pp. 407-409. Charles J.V. Murphy, "The Eisenhower Shift," Fortune (Mar 56), p. 232. 49. Memo, Pres to CJCS , "Project Solarium," 20

Time Reparametrization Group and the Long Time Behavior in Quantum Glassy Systems

NASA Astrophysics Data System (ADS)

Kennett, Malcolm P.; Chamon, Claudio

2001-02-01

We study the long time dynamics of a quantum version of the Sherrington-Kirkpatrick model. Time reparametrizations of the dynamical equations have a parallel with renormalization group transformations; in this language the long time behavior of this model is controlled by a reparametrization group ( RpG) fixed point of the classical dynamics. The irrelevance of quantum terms in the dynamical equations in the aging regime explains the classical nature of the out of equilibrium fluctuation-dissipation relation.

Development of X-Ray Laser Media. Measurement of Gain and Development of Cavity Resonators for Wavelengths near 130 Angstroms. Volume 3.

DTIC Science & Technology

1983-02-01

ray microscope (Kirkpatrick and Baez, 1948). At present such systems use single layer coatings illminated at very glancing angles. Ikltilayer coatings...might be useful as a means of operating such a system at an increased angle of incidence to the surface (this would reduce the geometrical aberrations...of the focussing elements); however our analysis of the LLE system indicates that one will have to accept a trade-off between collection aperture

Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirkpatrick, R. James

This document serves as the final report for United States Department of Energy Basic Energy Sciences Grant DE-FG02-08ER15929, “Computational and Spectroscopic Investigations of the Molecular Scale Structure and Dynamics of Geologically Important Fluids and Mineral-Fluid Interfaces” (R. James Kirkpatrick, P.I., A. O. Yazaydin, co-P.I.). The research under this grant was intimately tied to that supported by the parallel the grant of the same title at Alfred (DOE DE-FG02-10ER16128; Geoffrey M. Bowers, P.I.).

Evaluating the effectiveness of intercultural teachers.

PubMed

Cox, Kathleen

2011-01-01

With globalization and major immigration flows, intercultural teaching encounters are likely to increase, along with the need to assure intercultural teaching effectiveness.Thus, the purpose of this article is to present a conceptual framework for nurse educators to consider when anticipating an intercultural teaching experience. Kirkpatrick's and Bushnell's models provide a basis for the conceptual framework. Major concepts of the model include input, process, output, and outcome.The model may possibly be used to guide future research to determine which variables are most influential in explaining intercultural teaching effectiveness.

KSC00pp0054

NASA Image and Video Library

2000-01-14

Senator Connie Mack and Senator George Kirkpatrick talk before the Florida Space Summit being held today at the Kennedy Space Center Visitor Complex. The event, featuring a discussion on the future of space as it relates to the State of Florida and moderated by Center Director Roy Bridges, included participants such as Senator Bob Graham, Rep. Dave Weldon, members of Florida's State government including Gov. Jeb Bush, NASA Administrator Dan Goldin, 45th Space Wing Commander Brig. Gen. Donald Pettit and heads of aerospace companies

KSC-00pp0054

NASA Image and Video Library

2000-01-14

Senator Connie Mack and Senator George Kirkpatrick talk before the Florida Space Summit being held today at the Kennedy Space Center Visitor Complex. The event, featuring a discussion on the future of space as it relates to the State of Florida and moderated by Center Director Roy Bridges, included participants such as Senator Bob Graham, Rep. Dave Weldon, members of Florida's State government including Gov. Jeb Bush, NASA Administrator Dan Goldin, 45th Space Wing Commander Brig. Gen. Donald Pettit and heads of aerospace companies

Network Centric Warfare Case Study. U.S. V Corps and 3rd Infantry Division (Mechanized) During Operation Iraq Freedom Combat Operations (Mar-Apr 2003). Volume 1: Operations

DTIC Science & Technology

2003-11-01

Command Historian , and the personnel from the Center for Army Lessons Learned (CALL) for their assistance in gaining access to the many documents that...after the Network Centric Warfare Case Study operations. The Center for Army Lessons Learned (CALL), the V Corps Command Historian , and other... Historian , Dr. Charles Kirkpatrick, in Heidelberg, Germany, assisted in this effort. Nu- merous documents were collected, both unclassified and classified

Tackling Strategies for Thriving Geoscience Departments

NASA Astrophysics Data System (ADS)

Wuebbles, Donald J.; Takle, Eugene S.

2005-05-01

Special sessions on thriving geosciences departments and on cyberinfrastructure in the geosciences highlighted the recent 5th AGU Meeting of Heads and Chairs of Earth and Space Science Departments. ``From Surviving to Thriving: Strategies for Advancing University Geoscience Programs in Times of Change'' was a topic that drew intense interest. This panel discussion, led by Don Wuebbles (University of Illinois), included panelists Eric Betterton (University of Arizona), Judy Curry (Georgia Institute of Technology), Heather MacDonald (College of William and Mary), and Jim Kirkpatrick (University of Illinois).

Proceedings of the 2011 AFMS Medical Research Symposium. Volume 6. Traumatic Brain Injury (TBI) & Psychological Health Track

DTIC Science & Technology

2011-08-02

Representative > COL Leo Tucker, DCDD, User Representative > Dr. James Kirkpatrick. DCDD, Combat Developer > Mr. Willie Lindsay, AMEDD Test Board, Field...Scores 30l ll 25 :E ---- ~ 20 0 15 --~ f 10 =’ --- .t 0 --Controls - - concun1ons ---· lOC /AmnesiJ 151617181920 2122 2324 25 2627 282930 FIGURE...Psychological Health 99 ~;~haracteristics of concussion f’" . Concussion = mild lbi • Concussion may not always include loc • ’a trauma-induced

Sen2-Agri country level demonstration for Ukraine

NASA Astrophysics Data System (ADS)

Kussul, N.; Kolotii, A.; Shelestov, A.; Lavreniuk, M. S.

2016-12-01

Due to launch of Sentinel-2 mission European Space Agency (ESA) started Sentinel-2 for Agriculture (Sen2-Agri) project coordinated by Universite catholique de Louvain (UCL). Ukraine is selected as one of 3 country level demonstration sites for benchmarking Sentinel-2 data due to wide range of main crops (both winter and summer), big fields and high enough climate variability over the territory [1-2]. Within this county level demonstration main objectives are following: i) Sentinel's products quality assessment and their suitability estimation for the territory of Ukraine [2]; ii) demonstration in order to convince decision makers and state authorities; iii) assessment of the personnel and facilities required to run the Sen2-Agri system and creation of Sen-2 Agri products (crop type maps and such essential climatic variable as Leaf Area Index - LAI [3]). During this project ground data were collected for crop land mapping and crop type classification along the roads within main agro-climatic zones of Ukraine. For LAI estimation we used indirect non-destructive method which is based on DHP-images and VALERI protocol. Products created with use of Sen2-Agri system deployed during project execution and results of neural-network approach utilization will be compared. References Kussul, N., Lemoine, G., Gallego, F. J., Skakun, S. V., Lavreniuk, M., & Shelestov, A. Y. Parcel-Based Crop Classification in Ukraine Using Landsat-8 Data and Sentinel-1A Data. IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing , 9 (6), 2500-2508. Kussul, N., Skakun, S., Shelestov, A., Lavreniuk, M., Yailymov, B., & Kussul, O. (2015). Regional scale crop mapping using multi-temporal satellite imagery. The International Archives of Photogrammetry, Remote Sensing and Spatial Information Sciences, 40(7), 45-52. Shelestov, A., Kolotii, A., Camacho, F., Skakun, S., Kussul, O., Lavreniuk, M., & Kostetsky, O. (2015, July). Mapping of biophysical parameters based on high resolution EO imagery for JECAM test site in Ukraine. In 2015 IEEE International Geoscience and Remote Sensing Symposium (IGARSS), 1733-1736

Outcomes after the Mustard, Senning and arterial switch operation for treatment of transposition of the great arteries in Finland: a nationwide 4-decade perspective.

PubMed

Raissadati, Alireza; Nieminen, Heta; Sairanen, Heikki; Jokinen, Eero

2017-09-01

We analysed nationwide early and late results after the Mustard, Senning and arterial switch operation. We included all paediatric patients (<18 years) who underwent a Senning, a Mustard or an arterial switch operation for transposition of the great arteries from 1968 to 2009 in Finland. Data were obtained retrospectively from a paediatric cardiac surgical database and population data from the Finnish national registry. Early mortality (<30 days) was 11% after Mustard and 5% after Senning operation, while the rate decreased from 19% during 1976-1999 to 2% during 2000-2009 for arterial switch patients (P < 0.0001). The 43-year survival rate was 75% [95% confidence interval (CI) 70-80%] for all patients and 97% (95% CI 94-98%) for the general population. Late survival improved during later eras, with a 10-year survival of 96% (95% CI 92-99%) for those operated during 2000-2009 vs 81% (95% CI 74-88%) in the 1990s (hazard ratio 3.7, 95% CI 1.4-9.6, P = 0.008). Twenty-year survival rates (without 30-day mortality) after arterial switch operation, Mustard and Senning were 97% (95% CI 95-100%), 78% (95% CI 68-87%) and 84% (95% CI 77-90%), respectively. No late sudden deaths or fatal heart failures occurred after the arterial switch operation. Outcome after surgery for transposition of the great arteries has improved, mostly due to the arterial switch operation but also due to improvements in perioperative care and follow-up. Operative deaths after the arterial switch operation have diminished, and no late sudden deaths or fatal heart failures occurred during the first 25-30 years after the procedure. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Obstetric factors and different causes of special educational need: retrospective cohort study of 407,503 schoolchildren.

PubMed

Mackay, D F; Smith, G C S; Dobbie, R; Cooper, S-A; Pell, J P

2013-02-01

To determine whether relationships with gestational age and birthweight centile vary between specific causes of special educational need (SEN). Retrospective cohort study. Scotland. A cohort of 407,503 schoolchildren. Polytomous logistic regression was used to examine the risk of each cause of SEN across the spectrum of gestation at delivery and birthweight centile, adjusting for potential confounding factors. Crude and adjusted odds ratios and confidence intervals. Of the 19,821 children with SEN, 557 (2.8%) had sensory impairments, 812 (4.1%) had physical or motor disabilities, 876 (4.4%) had language impairments, 2823 (14.2%) had social, emotional, or behavioural problems, 7018 (35.4%) had intellectual disabilities, 4404 (22.2%) had specific learning difficulties, and 1684 (8.5%) autistic spectrum disorder (ASD). Extreme preterm delivery (at 24-27 weeks of gestation) was a strong predictor of sensory (adjusted OR 23.64, 95% CI 12.03-46.45), physical or motor (adjusted OR 29.69, 95% CI 17.49-50.40), and intellectual (adjusted OR 11.67, 95% CI 8.46-16.10) impairments, with dose relationships across the range of gestation. Similarly, birthweight below the third centile was associated with sensory (adjusted OR 2.85, 95% CI 2.04-3.99), physical or motor (adjusted OR 2.47, 95% CI 1.82-3.37), and intellectual (adjusted OR 2.67, 95% CI 2.41-2.96) impairments. Together, gestation and birthweight centile accounted for 24.0% of SEN arising from sensory impairment, 34.3% arising from physical or motor disabilities, and 26.6% arising from intellectual disabilities. Obstetric factors were less strongly associated with specific learning difficulties and social or emotional problems, and there were no significant associations with ASD. The association between gestation and birthweight centile and overall risk of SEN is largely driven by very strong associations with sensory, physical or motor impairments, and intellectual impairments. © 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.

Competitiveness and survival of two strains of Glossina palpalis gambiensis in an urban area of Senegal

PubMed Central

Bassène, Mireille Djimangali; Seck, Momar Talla; Pagabeleguem, Soumaïla; Fall, Assane Gueye; Sall, Baba; Vreysen, Marc J. B.; Gimonneau, Geoffrey

2017-01-01

Background In the Niayes area, located in the west of Senegal, only one tsetse species, Glossina palpalis gambiensis Vanderplank (Diptera: Glossinidae) was present. The Government of Senegal initiated and implemented an elimination programme in this area that included a sterile insect technique (SIT) component. The G. p. gambiensis strain (BKF) mass-reared at the Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES) in Burkina Faso was used for the SIT component. Methodology/principal findings Studies conducted in 2011 in four localities in the Niayes area (Pout, Sébikotane, Diacksao Peul and the Parc de Hann) showed that the BKF strain demonstrated inferior survival in the ecosystem of the Parc de Hann, a forested area in the city centre of the capital Dakar. Therefore, G. p. gambiensis flies from the Niayes area (SEN strain) were colonized. Here we compared the competitiveness and survival of the two strains (BKF and SEN) in the Parc de Hann. Released sterile males of the SEN colony showed a daily mortality rate of 0.08 (SD 0.08) as compared with 0.14 (SD 0.08) for the BKF flies but the difference was not significant (p-value = 0.14). However, the competitiveness of the SEN males was lower (0.14 (SD 0.10)) as compared with that of the BKF males (0.76 (SD 0.11)) (p-value < 10−3). Conclusions/significance Based on the results of this study, it can be concluded that the BKF strain will remain the main strain to be used in the elimination programme. Despite the slightly longer survival of the SEN males in the Parc de Hann, the superior competitiveness of the BKF males is deemed more important for the SIT component, as their shorter survival rates can be easily compensated for by more frequent fly releases. PMID:29281634

Competitiveness and survival of two strains of Glossina palpalis gambiensis in an urban area of Senegal.

PubMed

Bassène, Mireille Djimangali; Seck, Momar Talla; Pagabeleguem, Soumaïla; Fall, Assane Gueye; Sall, Baba; Vreysen, Marc J B; Gimonneau, Geoffrey; Bouyer, Jérémy

2017-12-01

In the Niayes area, located in the west of Senegal, only one tsetse species, Glossina palpalis gambiensis Vanderplank (Diptera: Glossinidae) was present. The Government of Senegal initiated and implemented an elimination programme in this area that included a sterile insect technique (SIT) component. The G. p. gambiensis strain (BKF) mass-reared at the Centre International de Recherche-Développement sur l'Elevage en zone Subhumide (CIRDES) in Burkina Faso was used for the SIT component. Studies conducted in 2011 in four localities in the Niayes area (Pout, Sébikotane, Diacksao Peul and the Parc de Hann) showed that the BKF strain demonstrated inferior survival in the ecosystem of the Parc de Hann, a forested area in the city centre of the capital Dakar. Therefore, G. p. gambiensis flies from the Niayes area (SEN strain) were colonized. Here we compared the competitiveness and survival of the two strains (BKF and SEN) in the Parc de Hann. Released sterile males of the SEN colony showed a daily mortality rate of 0.08 (SD 0.08) as compared with 0.14 (SD 0.08) for the BKF flies but the difference was not significant (p-value = 0.14). However, the competitiveness of the SEN males was lower (0.14 (SD 0.10)) as compared with that of the BKF males (0.76 (SD 0.11)) (p-value < 10-3). Based on the results of this study, it can be concluded that the BKF strain will remain the main strain to be used in the elimination programme. Despite the slightly longer survival of the SEN males in the Parc de Hann, the superior competitiveness of the BKF males is deemed more important for the SIT component, as their shorter survival rates can be easily compensated for by more frequent fly releases.

KSC-08pd1810

NASA Image and Video Library

2008-06-23

CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (right) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At the dais with Nelson are NASA Administrator Michael Griffin (left) and Florida Sen. Mel Martinez (center). Photo credit: NASA/Kim Shiflett

Test of SensL SiPM coated with NOL-1 wavelength shifter in liquid xenon

NASA Astrophysics Data System (ADS)

Akimov, D. Yu.; Belov, V. A.; Borshchev, O. V.; Burenkov, A. A.; Grishkin, Yu. L.; Karelin, A. K.; Kuchenkov, A. V.; Martemiyanov, A. N.; Ponomarenko, S. A.; Simakov, G. E.; Stekhanov, V. N.; Surin, N. M.; Timoshin, V. S.; Zeldovich, O. Ya.

2017-05-01

A SensL MicroFC-SMT-60035 6×6 mm2 silicon photo-multiplier coated with a NOL-1 wavelength shifter have been tested in the liquid xenon to detect the 175-nm scintillation light. For comparison, a Hamamatsu vacuum ultraviolet sensitive MPPC VUV3 3×3 mm2 was tested under the same conditions. The photodetection efficiency of 13.1 ± 2.5% and 6.0 ± 1.0%, correspondingly, is obtained.

Celebrating John Glenn’s Legacy

NASA Image and Video Library

2012-03-02

Sen. John Glenn, left, shakes hands with former Astronaut Steve Lindsey as NASA Administrator Charles Bolden smiles at an event celebrating John Glenn's legacy and 50 years of americans in orbit held at the Cleveland State University Wolstein Center on Friday, March 3, 2012 in Cleveland, Ohio. In 1998 Lindsey flew onboard the space shuttle Discovery along with then 77 year-old Sen. John Glenn for the STS-95 mission. Glenn became the first American to orbit Earth in 1962. Photo Credit: (NASA/Bill Ingalls)

The Cyclic Life-Test of a T5 Ion Thruster Hollow Cathode to 4200 Hours.

DTIC Science & Technology

1981-05-01

Conference on Fluid Mechanics in Energy Conversion, Alta (Utah) 1979, p. 263. (Published by SIAM, 1980.) Invited paper. 101. G.S.S. Ludford & Asok K. Sen...GCttingen 1979. Progress in Astronautics and Aeronautics, 76 (1981). p. 427. (Combustion in Reactive Systems, ed. by J. Ray Bowen, N. Manson, Antoni...steady detonation waves in a simple model problem. To appear in Studies in Applied Mathematics. 106. Asok K. Sen & G.S.S. Ludford: Effects of mass

BreathSens: A Continuous On-Bed Respiratory Monitoring System With Torso Localization Using an Unobtrusive Pressure Sensing Array.

PubMed

Liu, Jason J; Huang, Ming-Chun; Xu, Wenyao; Zhang, Xiaoyi; Stevens, Luke; Alshurafa, Nabil; Sarrafzadeh, Majid

2015-09-01

The ability to continuously monitor respiration rates of patients in homecare or in clinics is an important goal. Past research showed that monitoring patient breathing can lower the associated mortality rates for long-term bedridden patients. Nowadays, in-bed sensors consisting of pressure sensitive arrays are unobtrusive and are suitable for deployment in a wide range of settings. Such systems aim to extract respiratory signals from time-series pressure sequences. However, variance of movements, such as unpredictable extremities activities, affect the quality of the extracted respiratory signals. BreathSens, a high-density pressure sensing system made of e-Textile, profiles the underbody pressure distribution and localizes torso area based on the high-resolution pressure images. With a robust bodyparts localization algorithm, respiratory signals extracted from the localized torso area are insensitive to arbitrary extremities movements. In a study of 12 subjects, BreathSens demonstrated its respiratory monitoring capability with variations of sleep postures, locations, and commonly tilted clinical bed conditions.

Influence of sensitization on the discriminative stimulus effects of methylphenidate in mice.

PubMed

McGovern, Robin; Luderman, Lauryn; Knecht, Kelly; Griffin, William C

2014-12-01

Methylphenidate (MPH) remains an important therapy for attention-deficit hyperactivity disorder, but aspects of its pharmacology remain unclear. In the present study, we used a regimen of MPH (8 mg/kg daily×14 days) in C57BL/6J mice to determine whether establishing locomotor sensitization to MPH influenced the acquisition and the dose-response function of MPH in a classic drug discrimination procedure. MPH-sensitized mice (SENS group) showed enhanced locomotor activity to the 8 mg/kg exposure dose as well as a 2 mg/kg dose before discrimination training. However, the SENS mice did not acquire discrimination of either a low dose (2 mg/kg) or a higher dose (4 mg/kg) of MPH any more rapidly than the CTRL mice. Further, during generalization testing, the dose-response functions for the SENS and CTRL mice were identical. Therefore, we did not find that previous exposure to MPH, which produced a sensitized locomotor response, facilitated MPH discrimination.

State of the Art Control Measures for Aluminium Fade and SEN Clogging during Steelmaking Operations

NASA Astrophysics Data System (ADS)

Kamaraj, Ashok; Saravanakumar, R.; Rajaguru, M.

2018-02-01

Crack formation, fatigue failure of components and other process interruptions in liquid steel practices such as ladle nozzle clogging, SEN clogging, break outs are mainly due to residual deoxidation products such as alumina present in steels. The present paper deals with the issues in steel processing operations and provides state-of-the-art control measures for clean steel production. Investigations regarding the residual alumina content and its consequences at integrated steel plant shows that, Al-fade of maximum 0.02% is observed, which produces equivalent of 37 Kg of alumina in the liquid steel. Furthermore, slag carry over, re-oxidation, improper argon rinsing practice, aluminium consumption at secondary steelmaking practices also influences the alumina formation during steelmaking practices. The residual alumina not only affects the quality of steel, but also results in process interruptions such as ladle choking, SEN choking, subsequent break outs etc. various steelmaking practices influences clogging and aluminium fade are discussed and possible suggestions are given to improve the cleanliness of steel.

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office. Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. In this image, Sen. Mikulski receives an overview of the Asteroid Redirect Mission in front of mockups of the asteroid and capture vehicle. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Bill Hrybyk Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office. Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. In this image, a gathering of Goddard employees await the arrival of Sen. Mikulski to the facility. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Desiree Stover Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office (SSCO). Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. In this image, Sen. Mikulski receives an overview of NASA’s satellite servicing efforts from Benjamin Reed, deputy program manager of SSCO. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Desiree Stover Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Treatment of complex airway lesions after lung transplantation with self-expandable nitinol stents: early experience.

PubMed

Anile, M; Venuta, F; Diso, D; Liparulo, V; Ricella, C; De Giacomo, T; Pugliese, F; Rolla, M; Quattrucci, S; Pecoraro, Y; Rendina, E A; Coloni, G F

2010-05-01

Airway complications (AC) are considered a serious cause of morbidity after lung transplantation (LT). Mechanical dilatation, laser vaporization, and silicone stent placement usually solve it. However, the use of self-expandable metallic stents (SENS) may be indicated in selected cases. Ten lung transplant recipients with AC were treated with SENS. Six patients underwent LT for cystic fibrosis, 2 for idiopathic pulmonary fibrosis, 1 for bronchiectasis, and 1 for emphysema. All patients received at least 1 treatment attempt with dilatation and silicone stent placement. The indications for SENS placement were the presence of a tortuous airway axis with stenosis and malacia of the right main bronchus in 5 patients; a long stenosis of the main and intermediate right bronchus involving the upper lobe orifice in 3 patients; or malacia that could not be stabilized with silicone stents in 3 cases. In 1 patient the procedure was bilateral. Functional improvement was immediate with a mean forced expiratory volume at 1 second (FEV(1)) gain of 35%. No stent dislocation was observed. Symptoms did not occur again in 5 patients with previous recurrent episodes of pneumonia. One stenosis, which was due to the ingrowth of granulation tissue occurred at 6 months after the procedure, was successfully treated with mechanical dilatation and laser vaporization. The deployment of SENS in a selected group of patients with AC after LT was easy, safe, and effective. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Evaluation and impact of cardiotocography training programmes: a systematic review.

PubMed

Pehrson, C; Sorensen, J L; Amer-Wåhlin, I

2011-07-01

The interpretation and management of cardiotocography (CTG) tracings are often criticised in obstetric malpractice cases. As a consequence, regular CTG training has been recommended, even though little is known about the effect of CTG training. To perform a systematic review of the existing literature on studies on CTG training in order to assess educational strategies, evaluation of training programmes, and impact of training programmes. The Medline database was searched to identify studies describing and/or evaluating CTG training programmes. The literature search resulted in 409 citations. Twenty studies describing and evaluating CTG training programmes were included. There was no restriction on study design. Data regarding study design, study quality, educational strategies used for training in CTG interpretation and decision making, target groups, number of participants, methods used for evaluation, quality of evaluation, level of evaluation and results of training was extracted from 20 articles, and analysed using Kirkpatrick's four-level model for the evaluation of education. Training was associated with improvements on all Kirkpatrick levels, resulting in increased CTG knowledge and interpretive skills, higher interobserver agreement, better management of intrapartum CTG, and improved quality of care. Computer-based training (CBT) might be less time-consuming than classroom teaching. Clinical skills seem to decrease faster than theoretical knowledge. Training can improve CTG competence and clinical practise. Further research on CBT, test-enhanced learning and long-term retention, evaluation of training and impact on clinical outcomes is recommended. © 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.

Saving lives: A meta-analysis of team training in healthcare.

PubMed

Hughes, Ashley M; Gregory, Megan E; Joseph, Dana L; Sonesh, Shirley C; Marlow, Shannon L; Lacerenza, Christina N; Benishek, Lauren E; King, Heidi B; Salas, Eduardo

2016-09-01

As the nature of work becomes more complex, teams have become necessary to ensure effective functioning within organizations. The healthcare industry is no exception. As such, the prevalence of training interventions designed to optimize teamwork in this industry has increased substantially over the last 10 years (Weaver, Dy, & Rosen, 2014). Using Kirkpatrick's (1956, 1996) training evaluation framework, we conducted a meta-analytic examination of healthcare team training to quantify its effectiveness and understand the conditions under which it is most successful. Results demonstrate that healthcare team training improves each of Kirkpatrick's criteria (reactions, learning, transfer, results; d = .37 to .89). Second, findings indicate that healthcare team training is largely robust to trainee composition, training strategy, and characteristics of the work environment, with the only exception being the reduced effectiveness of team training programs that involve feedback. As a tertiary goal, we proposed and found empirical support for a sequential model of healthcare team training where team training affects results via learning, which leads to transfer, which increases results. We find support for this sequential model in the healthcare industry (i.e., the current meta-analysis) and in training across all industries (i.e., using meta-analytic estimates from Arthur, Bennett, Edens, & Bell, 2003), suggesting the sequential benefits of training are not unique to medical teams. Ultimately, this meta-analysis supports the expanded use of team training and points toward recommendations for optimizing its effectiveness within healthcare settings. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Informing web-based communication curricula in veterinary education: a systematic review of web-based methods used for teaching and assessing clinical communication in medical education.

PubMed

Artemiou, Elpida; Adams, Cindy L; Toews, Lorraine; Violato, Claudio; Coe, Jason B

2014-01-01

We determined the Web-based configurations that are applied to teach medical and veterinary communication skills, evaluated their effectiveness, and suggested future educational directions for Web-based communication teaching in veterinary education. We performed a systematic search of CAB Abstracts, MEDLINE, Scopus, and ERIC limited to articles published in English between 2000 and 2012. The review focused on medical or veterinary undergraduate to clinical- or residency-level students. We selected studies for which the study population was randomized to the Web-based learning (WBL) intervention with a post-test comparison with another WBL or non-WBL method and that reported at least one empirical outcome. Two independent reviewers completed relevancy screening, data extraction, and synthesis of results using Kirkpatrick and Kirkpatrick's framework. The search retrieved 1,583 articles, and 10 met the final inclusion criteria. We identified no published articles on Web based communication platforms in veterinary medicine; however, publications summarized from human medicine demonstrated that WBL provides a potentially reliable and valid approach for teaching and assessing communication skills. Student feedback on the use of virtual patients for teaching clinical communication skills has been positive,though evidence has suggested that practice with virtual patients prompted lower relation-building responses.Empirical outcomes indicate that WBL is a viable method for expanding the approach to teaching history taking and possibly to additional tasks of the veterinary medical interview.

Residents-as-Teachers Publications: What Can Programs Learn From the Literature When Starting a New or Refining an Established Curriculum?

PubMed

Bree, Kelly K; Whicker, Shari A; Fromme, H Barrett; Paik, Steve; Greenberg, Larrie

2014-06-01

Teaching residents how to teach is a critical part of resident education because residents are often the major teachers of medical students. The importance of formal residents-as-teachers (RAT) curricula has been emphasized throughout the literature, yet not all residency programs have such a curriculum in place. The purpose of our study was to (1) review the medical education literature for established RAT curricula, (2) assess published curricula's reproducibility, (3) evaluate the type of outcomes achieved using the Kirkpatrick model of evaluation, and (4) identify curricula that training programs could feasibly adopt. We performed a literature review using PubMed, Medline, Scopus, PsycINFO, ERIC, and Embase. Key search words included residents, residents as teachers, teaching, internship and residency, and curriculum. In addition, a search of MedEdPORTAL was performed using the same key terms. Articles were evaluated based on the reproducibility of curricula and the assessment tools. Evaluation of educational outcomes was performed using the Kirkpatrick model. Thirty-nine articles were deemed appropriate for review. Interventions and evaluation techniques varied greatly. Only 1 article from the literature was deemed to have both curricula and assessments that would be fully reproducible by other programs. A literature review on RAT curricula found few articles that would be easily reproduced for residency programs that want to start or improve their own RAT curricula. It also demonstrated the difficulty and lack of rigorous outcome measurements for most curricula.

Simulation based teaching in interventional radiology training: is it effective?

PubMed

Patel, R; Dennick, R

2017-03-01

To establish the educational effectiveness of simulation teaching in interventional radiology training. Electronic databases (MEDLINE, ERIC, Embase, OvidSP, and Cochrane Library) were searched (January 2000 to May 2015). Studies specifically with educational outcomes conducted on radiologists were eligible. All forms of simulation in interventional training were included. Data were extracted based on the population, intervention, comparison, and outcome (PICO) model. Kirkpatrick's hierarchy was used to establish educational intervention effectiveness. The quality of studies was assessed using the Cochrane risk of bias tool. Search resulted in 377 articles, of which 15 met the inclusion criteria. Thirteen of the 15 studies achieved level 2 of Kirkpatrick's hierarchy with only one reaching level 4. Statistically significant improvements in performance metrics as objective measures, demonstrating trainee competence were seen in 12/15 studies. Subjective improvements in confidence were noted in 13/15. Only one study demonstrated skills transferability and improvements in patient outcomes. Results demonstrate the relevance of simulated training to current education models in improving trainee competence; however, this is limited to the simulated environment as there is a lack of literature investigating its predictive validity and the effect on patient outcomes. The requirement for further research in this field is highlighted. Simulation is thus currently only deemed useful as an adjunct to current training models with the potential to play an influential role in the future of the interventional radiology training curriculum. Copyright © 2016. Published by Elsevier Ltd.

Isolation of a human intestinal anaerobe, Bifidobacterium sp. strain SEN, capable of hydrolyzing sennosides to sennidins.

PubMed Central

Akao, T; Che, Q M; Kobashi, K; Yang, L; Hattori, M; Namba, T

1994-01-01

A strictly anaerobic bacterium capable of metabolizing sennosides was isolated from human feces and identified as Bifidobacterium sp., named strain SEN. The bacterium hydrolyzed sennosides A and B to sennidins A and B via sennidin A and B 8-monoglucosides, respectively. Among nine species of Bifidobacterium having beta-glucosidase activity, only Bifidobacterium dentium and B. adolescentis metabolized sennoside B to sennidin B, suggesting that the sennoside-metabolizing bacteria produce a novel type of beta-glucosidase capable of hydrolyzing sennosides to sennidins. PMID:8161172

INFINITY ribbon-cutting

NASA Image and Video Library

2012-04-11

Ceremony participants prepare to cut the ribbon on the INFINITY at NASA Stennis Space Center facility April 11, 2012. Participating in the ceremony were (l to r): Gulfport Mayor and INFINITY Science Center Inc. Chairman George Schloegel; U.S. Rep. Steven Palazzo, R-Miss.; U.S. Sen. Roger Wicker, R-Miss.; Roy S. Estess granddaughter Lauren McKay; Mississippi Gov. Phil Bryant; Leo Seal Jr. grandson Leo Seal IV; Stennis Director Patrick Scheuermann; U.S. Sen. Thad Cochran, R-Miss.; NASA Chief of Staff David Radzanowski; and Apollo 13 astronaut and INFINITY Science Center Inc. Vice Chairman Fred Haise.

KSC-08pd1805

NASA Image and Video Library

2008-06-23

CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (right) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. On the left is Florida Sen. Mel Martinez. NASA was represented by Deputy Associate Administrator of Exploration Systems Doug Cooke, Administrator Michael Griffin and Associate Administrator of Space Operations William Gerstenmaier. Photo credit: NASA/Kim Shiflett

A Compendium of Portage Studies

DTIC Science & Technology

1982-02-01

M = 1.5W + 2.0(W+L)(L/W)2 + E(W+L)(1.5V2 + 0.35VG) (1) where M = metabolic cost (watts) W = subject weight, nude (kg) L = external load (kg) E...footing factor V = velocity ( m /sec) G = grade or slope (%) While it may not always result in an accurate prediction, Formula 1 does incorporate...Randall, R.B. Ray, S.N. Redfearn, J.W.T. Reid, A.M. Renbourne, E.T. Ress, M . Richardson, D.T. Roy, B.N. Saha, P.N. Sanders, J.H. Sen, R.N. Sen

John Glenn during preflight training for STS-95

NASA Image and Video Library

1998-04-14

S98-06944 (28 April 1998) --- U.S. Sen. John H. Glenn Jr. (D.-Ohio) prepares to rehearse launch readiness procedures on the middeck of a crew trainer at the Johnson Space Center (JSC). Sharon Jones, involved in crew training, briefs the STS-95 payload specialist. When he lifts off aboard the Space Shuttle Discovery in October of this year and later lands in Florida, Sen. Glenn will be seated in a temporary middeck chair like the one used in this training exercise. The photo was taken by Joe McNally, National Geographic, for NASA.

Scanning three-dimensional x-ray diffraction microscopy using a high-energy microbeam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hayashi, Y., E-mail: y-hayashi@mosk.tytlabs.co.jp; Hirose, Y.; Seno, Y.

2016-07-27

A scanning three-dimensional X-ray diffraction (3DXRD) microscope apparatus with a high-energy microbeam was installed at the BL33XU Toyota beamline at SPring-8. The size of the 50 keV beam focused using Kirkpatrick-Baez mirrors was 1.3 μm wide and 1.6 μm high in full width at half maximum. The scanning 3DXRD method was tested for a cold-rolled carbon steel sheet sample. A three-dimensional orientation map with 37 {sup 3} voxels was obtained.

Collective Political Violence in Easton’s Political Systems Model (La Violence Politique Collective dans le Modele de Systeme Politique d’Easton)

DTIC Science & Technology

2011-09-01

opérationnelle) [ novembre 2010], note publiée pendant la première phase du projet, soit l’élaboration conceptuelle du programme de recherche. DRDC Toronto...Kirkpatrick, D. & Sanger, D. (2011). A Tunisian-Egyptian link that shook Arab history. The New York Times, 13 February 2011. Martin, J. (1986). The...body of abstract and indexing annotation must be entered when the overall document is classified) 13 . ABSTRACT (A brief and factual summary of the

High-pressure pair distribution function (PDF) measurement using high-energy focused x-ray beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hong, Xinguo, E-mail: xhong@bnl.gov; Weidner, Donald J.; Ehm, Lars

In this paper, we report recent development of the high-pressure pair distribution function (HP-PDF) measurement technique using a focused high-energy X-ray beam coupled with a diamond anvil cell (DAC). The focusing optics consist of a sagittally bent Laue monochromator and Kirkpatrick-Baez (K–B) mirrors. This combination provides a clean high-energy X-ray beam suitable for HP-PDF research. Demonstration of the HP-PDF technique for nanocrystalline platinum under quasi-hydrostatic condition above 30 GPa is presented.

Nondispersive neutron focusing method beyond the critical angle of mirrors

DOEpatents

Ice, Gene E.

2008-10-21

This invention extends the Kirkpatrick-Baez (KB) mirror focusing geometry to allow nondispersive focusing of neutrons with a convergence on a sample much larger than is possible with existing KB optical schemes by establishing an array of at least three mirrors and focusing neutrons by appropriate multiple deflections via the array. The method may be utilized with supermirrors, multilayer mirrors, or total external reflection mirrors. Because high-energy x-rays behave like neutrons in their absorption and reflectivity rates, this method may be used with x-rays as well as neutrons.

Automated analysis of long-term bridge behavior and health using a cyber-enabled wireless monitoring system

NASA Astrophysics Data System (ADS)

O'Connor, Sean M.; Zhang, Yilan; Lynch, Jerome; Ettouney, Mohammed; van der Linden, Gwen

2014-04-01

A worthy goal for the structural health monitoring field is the creation of a scalable monitoring system architecture that abstracts many of the system details (e.g., sensors, data) from the structure owner with the aim of providing "actionable" information that aids in their decision making process. While a broad array of sensor technologies have emerged, the ability for sensing systems to generate large amounts of data have far outpaced advances in data management and processing. To reverse this trend, this study explores the creation of a cyber-enabled wireless SHM system for highway bridges. The system is designed from the top down by considering the damage mechanisms of concern to bridge owners and then tailoring the sensing and decision support system around those concerns. The enabling element of the proposed system is a powerful data repository system termed SenStore. SenStore is designed to combine sensor data with bridge meta-data (e.g., geometric configuration, material properties, maintenance history, sensor locations, sensor types, inspection history). A wireless sensor network deployed to a bridge autonomously streams its measurement data to SenStore via a 3G cellular connection for storage. SenStore securely exposes the bridge meta- and sensor data to software clients that can process the data to extract information relevant to the decision making process of the bridge owner. To validate the proposed cyber-enable SHM system, the system is implemented on the Telegraph Road Bridge (Monroe, MI). The Telegraph Road Bridge is a traditional steel girder-concrete deck composite bridge located along a heavily travelled corridor in the Detroit metropolitan area. A permanent wireless sensor network has been installed to measure bridge accelerations, strains and temperatures. System identification and damage detection algorithms are created to automatically mine bridge response data stored in SenStore over an 18-month period. Tools like Gaussian Process (GP) regression are used to predict changes in the bridge behavior as a function of environmental parameters. Based on these analyses, pertinent behavioral information relevant to bridge management is autonomously extracted.

Pregnancy Complications as Markers for Subsequent Maternal Cardiovascular Disease: Validation of a Maternal Recall Questionnaire.

PubMed

Carter, Ebony Boyce; Stuart, Jennifer J; Farland, Leslie V; Rich-Edwards, Janet W; Zera, Chloe A; McElrath, Thomas F; Seely, Ellen W

2015-09-01

We designed and tested the validity of a questionnaire to characterize maternal recall of pregnancy complications associated with increased future cardiovascular disease risk, based on the 2011 American Heart Association (AHA) guidelines. A maternal recall questionnaire of pregnancy history was administered to 971 patients who had participated in a previous cohort study of 1,608 pregnant women. Medical records from the study pregnancy served as the gold standard. Prevalence, sensitivity (sens), specificity (spec), positive predictive value (PPV), negative predictive value (NPV), and/or Spearman's correlation coefficients (r) were calculated for each question. A total of 526 (54%) individuals recontacted responded. Respondents were more likely to be older, white, educated, and nulliparous and were less likely to deliver low-birthweight infants in the study pregnancy than were individuals who did not respond. Mean length of recall was 4.35 years (standard deviation [SD] 0.46) postpartum. Maternal recall was most accurate for gestational diabetes (sens: 92%, spec: 98%, PPV: 79%, NPV: 99%), infant birthweight (r=0.95), and gestation length (r=0.85). Maternal recall was modest for preeclampsia (sens: 79%, spec: 97%, PPV: 68%, NPV: 98%) and pregnancy-associated hypertension, including preeclampsia or gestational hypertension (sens: 60%, spec: 95%, PPV: 64%, NPV: 94%). This validation study demonstrated that the majority of women could accurately recall a history of gestational diabetes, infant birthweight, and gestational age at delivery, 4 years postpartum on average. Recall of preeclampsia and pregnancy-associated hypertension overall was modest. Maternal report of these pregnancy conditions may help clinicians identify women at increased risk for cardiovascular disease.

Binary Cell Fate Decisions and Fate Transformation in the Drosophila Larval Eye

PubMed Central

Rister, Jens; Ng, June; Celik, Arzu; Sprecher, Simon G.

2013-01-01

The functionality of sensory neurons is defined by the expression of specific sensory receptor genes. During the development of the Drosophila larval eye, photoreceptor neurons (PRs) make a binary choice to express either the blue-sensitive Rhodopsin 5 (Rh5) or the green-sensitive Rhodopsin 6 (Rh6). Later during metamorphosis, ecdysone signaling induces a cell fate and sensory receptor switch: Rh5-PRs are re-programmed to express Rh6 and become the eyelet, a small group of extraretinal PRs involved in circadian entrainment. However, the genetic and molecular mechanisms of how the binary cell fate decisions are made and switched remain poorly understood. We show that interplay of two transcription factors Senseless (Sens) and Hazy control cell fate decisions, terminal differentiation of the larval eye and its transformation into eyelet. During initial differentiation, a pulse of Sens expression in primary precursors regulates their differentiation into Rh5-PRs and repression of an alternative Rh6-cell fate. Later, during the transformation of the larval eye into the adult eyelet, Sens serves as an anti-apoptotic factor in Rh5-PRs, which helps in promoting survival of Rh5-PRs during metamorphosis and is subsequently required for Rh6 expression. Comparably, during PR differentiation Hazy functions in initiation and maintenance of rhodopsin expression. Hazy represses Sens specifically in the Rh6-PRs, allowing them to die during metamorphosis. Our findings show that the same transcription factors regulate diverse aspects of larval and adult PR development at different stages and in a context-dependent manner. PMID:24385925

Crystallization and preliminary characterization of a novel haem-binding protein of Streptomyces reticuli

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zou, Peijian; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg; Groves, Matthew R.

2008-05-01

The haem-binding protein HbpS from Streptomyces reticuli was crystallized and diffraction data were collected to a maximal resolution of 2.25 Å. Streptomyces reticuli is a soil-growing Gram-positive bacteria that has been shown to secrete a novel haem-binding protein known as HbpS. Sequence analysis reveals that homologues of HbpS are found in a wide variety of bacteria, including different Actinobacteria and the Gram-negative Vibrio cholera and Klebsiella pneumoniae. The in vivo production of HbpS is greatly increased when S. reticuli is cultured in the presence of the natural antibiotic haemin (Fe{sup 3+} oxidized form of haem). Mutational analysis demonstrated that HbpSmore » significantly increases the resistance of S. reticuli to toxic concentrations of haemin. Previous data show that the presence of the newly identified two-component sensor system SenS–SenR also considerably enhances the resistance of S. reticuli to haemin and the redox-cycling compound plumbagin, suggesting a role in the sensing of redox changes. Specific interaction between HbpS and SenS–SenR, which regulates the expression of the catalase–peroxidase CpeB, as well as HbpS, has been demonstrated in vitro. HbpS has been recombinantly overexpressed, purified and crystallized in space group P2{sub 1}3, with a cell edge of 152.5 Å. Diffraction data were recorded to a maximal resolution of 2.25 Å and phases were obtained using the SAD method from crystals briefly soaked in high concentrations of sodium bromide.« less

Binary cell fate decisions and fate transformation in the Drosophila larval eye.

PubMed

Mishra, Abhishek Kumar; Tsachaki, Maria; Rister, Jens; Ng, June; Celik, Arzu; Sprecher, Simon G

2013-01-01

The functionality of sensory neurons is defined by the expression of specific sensory receptor genes. During the development of the Drosophila larval eye, photoreceptor neurons (PRs) make a binary choice to express either the blue-sensitive Rhodopsin 5 (Rh5) or the green-sensitive Rhodopsin 6 (Rh6). Later during metamorphosis, ecdysone signaling induces a cell fate and sensory receptor switch: Rh5-PRs are re-programmed to express Rh6 and become the eyelet, a small group of extraretinal PRs involved in circadian entrainment. However, the genetic and molecular mechanisms of how the binary cell fate decisions are made and switched remain poorly understood. We show that interplay of two transcription factors Senseless (Sens) and Hazy control cell fate decisions, terminal differentiation of the larval eye and its transformation into eyelet. During initial differentiation, a pulse of Sens expression in primary precursors regulates their differentiation into Rh5-PRs and repression of an alternative Rh6-cell fate. Later, during the transformation of the larval eye into the adult eyelet, Sens serves as an anti-apoptotic factor in Rh5-PRs, which helps in promoting survival of Rh5-PRs during metamorphosis and is subsequently required for Rh6 expression. Comparably, during PR differentiation Hazy functions in initiation and maintenance of rhodopsin expression. Hazy represses Sens specifically in the Rh6-PRs, allowing them to die during metamorphosis. Our findings show that the same transcription factors regulate diverse aspects of larval and adult PR development at different stages and in a context-dependent manner.

Molecular cloning and cold shock induced overexpression of the DNA encoding phor sensor domain from Mycobacterium tuberculosis as a target molecule for novel anti-tubercular drugs

NASA Astrophysics Data System (ADS)

Langi, Gladys Emmanuella Putri; Moeis, Maelita R.; Ihsanawati, Giri-Rachman, Ernawati Arifin

2014-03-01

Mycobacterium tuberculosis (Mtb), the sole cause of Tuberculosis (TB), is still a major global problem. The discovery of new anti-tubercular drugs is needed to face the increasing TB cases, especially to prevent the increase of cases with resistant Mtb. A potential novel drug target is the Mtb PhoR sensor domain protein which is the histidine kinase extracellular domain for receiving environmental signals. This protein is the initial part of the two-component system PhoR-PhoP regulating 114 genes related to the virulence of Mtb. In this study, the gene encoding PhoR sensor domain (SensPhoR) was subcloned from pGEM-T SensPhoR from the previous study (Suwanto, 2012) to pColdII. The construct pColdII SensPhoR was confirmed through restriction analysis and sequencing. Using the construct, SensPhoR was overexpressed at 15°C using Escherichia coli BL21 (DE3). Low temperature was chosen because according to the solubility prediction program of recombinant proteins from The University of Oklahama, the PhoR sensor domain has a chance of 79.8% to be expressed as insoluble proteins in Escherichia coli's (E. coli) cytoplasm. This prediction is also supported by other similar programs: PROSO and PROSO II. The SDS PAGE result indicated that the PhoR sensor domain recombinant protein was overexpressed. For future studies, this protein will be purified and used for structure analysis which can be used to find potential drugs through rational drug design.

Influence of Vertical Electromagnetic Brake on the Steel/Slag Interface Behavior in a Slab Mold

NASA Astrophysics Data System (ADS)

Li, Zhuang; Wang, Engang; Zhang, Lintao; Xu, Yu; Deng, Anyuan

2017-10-01

The steel/slag interface behavior under a new type of electromagnetic brake (EMBr), vertical electromagnetic brake (V-EMBr), was investigated. The influence of the magnetic induction intensity, the submerged entry nozzle (SEN) immersion depth, and the port angle of the SEN are investigated numerically. The effect of magnetic induction intensity on the meniscus fluctuation of molten alloy is further studied by the experiments. The results show that the meniscus fluctuation is depressed as the magnetic induction intensity is increased, especially for the region in the vicinity of the narrow face of the slab mold. This result is validated by the following experiments. For the influence of the SEN immersion depth and the port angle, the results show that the meniscus fluctuation is suppressed as the values of the immersion depth and the port angle are increased (absolute values for the port angle). However, the influence of the immersion depth and the port angle are not as sensitive as those in the other type of EMBr, e.g., EMBr Ruler. The industrial application of V-EMBr could benefit from this result.

Cosmic censorship conjecture in Kerr-Sen black hole

NASA Astrophysics Data System (ADS)

Gwak, Bogeun

2017-06-01

The validity of the cosmic censorship conjecture for the Kerr-Sen black hole, which is a solution to the low-energy effective field theory for four-dimensional heterotic string theory, is investigated using charged particle absorption. When the black hole absorbs the particle, the charge on it changes owing to the conserved quantities of the particle. Changes in the black hole are constrained to the equation for the motion of the particle and are consistent with the laws of thermodynamics. Particle absorption increases the mass of the Kerr-Sen black hole to more than that of the absorbed charges such as angular momentum and electric charge; hence, the black hole cannot be overcharged. In the near-extremal black hole, we observe a violation of the cosmic censorship conjecture for the angular momentum in the first order of expansion and the electric charge in the second order. However, considering an adiabatic process carrying the conserved quantities as those of the black hole, we prove the stability of the black hole horizon. Thus, we resolve the violation. This is consistent with the third law of thermodynamics.

Research Center Renaming Will Honor Senator Domenici

NASA Astrophysics Data System (ADS)

2008-05-01

New Mexico Tech and the National Radio Astronomy Observatory (NRAO) will rename the observatory's research center on the New Mexico Tech campus to honor retiring U.S. Senator Pete V. Domenici in a ceremony on May 30. The building that serves as the scientific, technical, and administrative center for the Very Large Array (VLA) and Very Long Baseline Array (VLBA) radio telescopes will be named the "Pete V. Domenici Science Operations Center." The building previously was known simply as the "Array Operations Center." Sen. Pete V. Domenici Sen. Pete V. Domenici "The new name recognizes the strong and effective support for science that has been a hallmark of Senator Domenici's long career in public service," said Dr. Fred Lo, NRAO Director. New Mexico Tech President Daniel H. Lopez said Sen. Domenici has always been a supporter of science and research in Socorro and throughout the state. "He's been a statesman for New Mexico, the nation -- and without exaggeration -- for the world," Lopez said. "Anyone with that track record deserves this recognition." Van Romero, Tech vice president of research and economic development, has served as the university's main lobbyist in Washington, D.C., for more than a decade. He said Sen. Domenici has always been receptive to new ideas and willing to take risks. "Over the years, Sen. Domenici has always had time to listen to our needs and goals," Romero said. "He has served as a champion of New Mexico Tech's causes and we owe him a debt of gratitude for all his efforts over the decades." Originally dedicated in 1988, the center houses offices and laboratories that support VLA and VLBA operations. The center also supports work on the VLA modernization project and on the international Atacama Large Millimeter/submillimeter Array (ALMA) project. Work on ALMA at the Socorro center and at the ALMA Test Facility at the VLA site west of Socorro has focused on developing and testing equipment to be deployed at the ALMA site in Chile's Atacama Desert. The research facility, part of the National Science Foundation-funded NRAO, was located on the NM Tech campus through a joint Federal-State effort spearheaded by Domenici. "Senator Domenici has worked hard over the years to support research both at New Mexico Tech and at the NRAO, and our facility on the New Mexico Tech campus is a symbol of that support. It's highly appropriate to name it after him," said Dr. Ethan Schreier, President of Associated Universities Inc., which operates the NRAO for the National Science Foundation. Senator Domenici helped make New Mexico Tech's Magdalena Ridge Observatory (MRO) a reality and provided essential support for NRAO's VLA and VLBA. MRO is one of the world's most technologically-advanced optical observatories. The VLA is the most scientifically-productive ground-based telescope in the history of astronomy. "Both these facilities will advance the frontiers of 21st-Century astrophysics, and keep our state and its research community in the forefront of science worldwide," said Dr. Robert Dickman, NRAO's Director for New Mexico Operations. Domenici also was instrumental in bringing the International Law Enforcement Academy -- another New Mexico Tech division -- to Roswell. During the Reagan Administration, Domenici sponsored the legislation that allowed the university to use the "M" Mountain range for research and testing. Lopez said the U.S. Department of the Interior would not let the university conduct testing on the range. A high level bureaucrat told Laurence Lattman, then the president of Tech, that it "would take an act of Congress" for Tech to have unlimited access to the land. Domenici sponsored the legislation -- signed by Reagan -- that gave Tech access to the land. Over the years, Domenici's support has helped Tech launch the homeland security training program in Playas, the EarthScope research and other anti-terrorism training programs. "All these projects benefit New Mexico Tech," Lopez said. "But these programs also benefit the nation. Senator Domenici has always been careful to make sure that federal money went to programs that benefit the entire nation." The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under cooperative agreement by Associated Universities, Inc.

Retrieval of Optical Parameters From Seawifs Observations Over The Pomme Area (north-est Atlantic): Biogeochemical Applications

NASA Astrophysics Data System (ADS)

Loisel, H.; Nicolas, J.-M.; Merien, D.; Claustre, H.; Sciandra, A.; Becu, G.; Deschamps, P.-Y.

Since the success of the first ocean color instrument, the Coastal Zone Color Sen- sor (CZCS), the interpretation of ocean color in terms of phytoplankton pigment (the chlorophyll, Chl) is now well recognized. The chlorophyll data, as detected from space, are now currently used to constraint oceanic biological models. New gener- ation of biological models now integrate explicitly 2 or more species of plankton, as well as dissolved organic and particulate matter, DOC and POC, respectively. The as- sessment of such information from the Sea-viewing Wide Field-of-view Sensor and inverse modeling will be discussed. In the frame of the POMME (Programme Océan Multidisciplinaire Méso-Echelle) project we will present the seasonal variability of the absorption, a, the backscattering, bb, and the scattering, b, coefficients as retrieved from SeaWiFS observations over the POMME area. These optical parameters will be compared with in situ measurements made during winter, spring and summer 2001, and biological information derived from these optical properties retrieved at different wavelengths will be presented.

A well-defined Pd hybrid material for the Z-selective semihydrogenation of alkynes characterized at the molecular level by DNP SENS.

PubMed

Conley, Matthew P; Drost, Ruben M; Baffert, Mathieu; Gajan, David; Elsevier, Cornelis; Franks, W Trent; Oschkinat, Hartmut; Veyre, Laurent; Zagdoun, Alexandre; Rossini, Aaron; Lelli, Moreno; Lesage, Anne; Casano, Gilles; Ouari, Olivier; Tordo, Paul; Emsley, Lyndon; Copéret, Christophe; Thieuleux, Chloé

2013-09-09

Direct evidence of the conformation of a Pd-N heterocyclic carbene (NHC) moiety imbedded in a hybrid material and of the Pd-NHC bond were obtained by dynamic nuclear polarization surface-enhanced NMR spectroscopy (DNP SENS) at natural abundance in short experimental times (hours). Overall, this silica-based hybrid material containing well-defined Pd-NHC sites in a uniform environment displays high activity and selectivity in the semihydrogenation of alkynes into Z-alkenes (see figure). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KSC-04PD-1557

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Sen. John F. Kerry, D-Mass., greets Kennedy Space Center employees during a tour of the Orbiter Processing Facility (OPF). The orbiter Discovery is being prepared for flight in the OPF on the next Space Shuttle mission. The tour follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes Americas commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-04pd1557

NASA Image and Video Library

2004-07-26

KENNEDY SPACE CENTER, FLA. - Sen. John F. Kerry, D-Mass., greets Kennedy Space Center employees during a tour of the Orbiter Processing Facility (OPF). The orbiter Discovery is being prepared for flight in the OPF on the next Space Shuttle mission. The tour follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes America’s commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-08pd1804

NASA Image and Video Library

2008-06-23

CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (third from right on the dais) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At Nelson's right is Florida Sen. Mel Martinez. Seated at left are NASA representatives Deputy Associate Administrator of Exploration Systems Doug Cooke, Administrator Michael Griffin and Associate Administrator of Space Operations William Gerstenmaier. Photo credit: NASA/Kim Shiflett

Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

PubMed Central

Ashley, Elizabeth A; Touabi, Malek; Ahrer, Margareta; Hutagalung, Robert; Htun, Khayae; Luchavez, Jennifer; Dureza, Christine; Proux, Stephane; Leimanis, Mara; Lwin, Myo Min; Koscalova, Alena; Comte, Eric; Hamade, Prudence; Page, Anne-Laure; Nosten, François; Guerin, Philippe J

2009-01-01

Background In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). Methods In Dawei, southern Myanmar, three pLDH based RDTs (CareStart™ Malaria pLDH (Pan), CareStart™ Malaria pLDH (Pan, Pf) and OptiMAL-IT®)were evaluated in patients presenting with clinically suspected malaria. Each RDT was read independently by two readers. A subset of patients with microscopically confirmed malaria had their RDTs repeated on days 2, 7 and then weekly until negative. At the end of the study, samples of study batches were sent for heat stability testing. Results Between August and November 2007, 1004 patients aged between 1 and 93 years were enrolled in the study. Slide microscopy (the reference standard) diagnosed 213 Plasmodium vivax (Pv) monoinfections, 98 Plasmodium falciparum (Pf) mono-infections and no malaria in 650 cases. The sensitivities (sens) and specificities (spec), of the RDTs for the detection of malaria were- CareStart Malaria™ pLDH (Pan) test: sens 89.1% [CI95 84.2-92.6], spec 97.6% [CI95 96.5-98.4] OptiMal-IT®: Pf+/- other species detection: sens 95.2% [CI95 87.5-98.2], spec 94.7% [CI95 93.3-95.8]; non-Pf detection alone: sens 89.6% [CI95 83.6-93.6], spec 96.5% [CI95 94.8-97.7] CareStart Malaria™ pLDH (Pan, Pf): Pf+/- other species: sens 93.5% [CI9585.4-97.3], spec 97.4% [95.9-98.3]; non-Pf: sens 78.5% [CI9571.1-84.4], spec 97.8% [CI95 96.3-98.7] Inter-observer agreement was excellent for all tests (kappa > 0.9). The median time for the RDTs to become negative was two days for the CareStart™ Malaria tests and seven days for OptiMAL-IT®. Tests were heat stable up to 90 days except for OptiMAL-IT® (Pf specific pLDH stable to day 20 at 35°C). Conclusion None of the pLDH-based RDTs evaluated was able to detect non-falciparum malaria with high sensitivity, particularly at low parasitaemias. OptiMAL-IT® performed best overall and would perform best in an area of high malaria prevalence among screened fever cases. However, heat stability was unacceptable and the number of steps to perform this test is a significant drawback in the field. A reliable, heat-stable, highly sensitive RDT, capable of diagnosing all Plasmodium species has yet to be identified. PMID:19860920

Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria.

PubMed

Ashley, Elizabeth A; Touabi, Malek; Ahrer, Margareta; Hutagalung, Robert; Htun, Khayae; Luchavez, Jennifer; Dureza, Christine; Proux, Stephane; Leimanis, Mara; Lwin, Myo Min; Koscalova, Alena; Comte, Eric; Hamade, Prudence; Page, Anne-Laure; Nosten, François; Guerin, Philippe J

2009-10-27

In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). In Dawei, southern Myanmar, three pLDH based RDTs (CareStart Malaria pLDH (Pan), CareStart Malaria pLDH (Pan, Pf) and OptiMAL-IT)were evaluated in patients presenting with clinically suspected malaria. Each RDT was read independently by two readers. A subset of patients with microscopically confirmed malaria had their RDTs repeated on days 2, 7 and then weekly until negative. At the end of the study, samples of study batches were sent for heat stability testing. Between August and November 2007, 1004 patients aged between 1 and 93 years were enrolled in the study. Slide microscopy (the reference standard) diagnosed 213 Plasmodium vivax (Pv) monoinfections, 98 Plasmodium falciparum (Pf) mono-infections and no malaria in 650 cases. The sensitivities (sens) and specificities (spec), of the RDTs for the detection of malaria were- CareStart Malaria pLDH (Pan) test: sens 89.1% [CI95 84.2-92.6], spec 97.6% [CI95 96.5-98.4]. OptiMal-IT: Pf+/- other species detection: sens 95.2% [CI95 87.5-98.2], spec 94.7% [CI95 93.3-95.8]; non-Pf detection alone: sens 89.6% [CI95 83.6-93.6], spec 96.5% [CI95 94.8-97.7]. CareStart Malaria pLDH (Pan, Pf): Pf+/- other species: sens 93.5% [CI95 85.4-97.3], spec 97.4% [95.9-98.3]; non-Pf: sens 78.5% [CI95 71.1-84.4], spec 97.8% [CI95 96.3-98.7]. Inter-observer agreement was excellent for all tests (kappa > 0.9). The median time for the RDTs to become negative was two days for the CareStart Malaria tests and seven days for OptiMAL-IT. Tests were heat stable up to 90 days except for OptiMAL-IT (Pf specific pLDH stable to day 20 at 35 degrees C). None of the pLDH-based RDTs evaluated was able to detect non-falciparum malaria with high sensitivity, particularly at low parasitaemias. OptiMAL-IT performed best overall and would perform best in an area of high malaria prevalence among screened fever cases. However, heat stability was unacceptable and the number of steps to perform this test is a significant drawback in the field. A reliable, heat-stable, highly sensitive RDT, capable of diagnosing all Plasmodium species has yet to be identified.

Inclusion behaviour in the liquid core during continuous casting

NASA Astrophysics Data System (ADS)

Jiang, Guang S.

Water models using perspex have been built to study the fluid flow and recirculation patterns developed in the sump of a steel continuous casting machine and the influences these have on the behaviour of inclusions. An experimental method has been devised to simulate the behaviour of inclusions in the sump and to study the apportionment of the input flux of inclusions between the molten mould powder layer and the strand. The method entails the uses of finely dispersed coloured paraffin oil in the inlet stream together with a floating colourless paraffin layer on the top of the water in the model mould to simulate the molten powder layer on top of the molten steel.A theoretical model has been formulated which relates the inclusion separation in the sump to the fluid flow there. The inclusion removal ratio in the sump for a given continuous casting machine can be predicted using this theoretical model. The model, using the properties of liquid steel and practicable casting speeds, demonstrates that the removal of inclusions of small size (<40 um) from the mould sump is less than 5% efficient.Inclusion agglomeration plays an important role in inclusion removal. It has been shown that deep submersion of the SEN enhances the agglomeration of inclusion particle. Under certain conditions, for example, the average particle diameter in the meniscus region has been found to be as much as three times its value at the SEN nozzle.The use of fine alumina flakes or small air bubbles, together with a plane light source, has been found to be very successful in studying the fluid flow patterns developed in three-dimensional models. Employing this method, the fluid flow patterns developed on different planes within the model mould have been viewed and recorded photographically. The photographs so obtained have helped to explain the results obtained for the removal of inclusions. The fluid flow patterns developed when small outside diameter nozzles with deep SEN submerged depths are used have been found to be of benefit to the removal of inclusions.Increasing the SEN submerged depth promotes inclusion agglomeration and hence increases the inclusion removal ratio. Reducing the nozzle outside diameter and the casting speed increases the inclusion removal ratio in the sump. But the infleunces of these latter changes are not very strong, so that inclusion removal consideration need not influence the design strategies used for the casting speed and nozzle outside diameter. The SEN port angle has a little effect on the inclusion removal when using deep SEN submerged depth.Although argon stream introduced into the tundish nozzle stream can protect the nozzle blockage, it is not beneficial to the inclusion removal in the sump.

Alternative designs for space x-ray telescopes

NASA Astrophysics Data System (ADS)

Hudec, R.; Pína, L.; Maršíková, Veronika; Černá, Daniela; Inneman, A.; Tichý, V.

2017-11-01

The X-ray optics is a key element of space X-ray telescopes, as well as other X-ray imaging instruments. The grazing incidence X-ray lenses represent the important class of X-ray optics. Most of grazing incidence (reflective) X-ray imaging systems used in astronomy but also in other (laboratory) applications are based on the Wolter 1 (or modified) arrangement. But there are also other designs and configurations proposed, used and considered for future applications both in space and in laboratory. The Kirkpatrick-Baez (K-B) lenses as well as various types of Lobster-Eye optics and MCP/Micropore optics serve as an example. Analogously to Wolter lenses, the X-rays are mostly reflected twice in these systems to create focal images. Various future projects in X-ray astronomy and astrophysics will require large segments with multiple thin shells or foils. The large Kirkpatrick-Baez modules, as well as the large Lobster-Eye X-ray telescope modules in Schmidt arrangement may serve as examples. All related space projects will require high quality and light segmented shells (bent or flat foils) with high X-ray reflectivity and excellent mechanical stability. The Multi Foil Optics (MFO) approach represent a promising alternative for both LE and K-B X-ray optical modules. Several types of reflecting substrates may be considered for these applications, with emphasis on thin float glass sheets and, more recently, high quality silicon wafers. This confirms the importance of non-Wolter X-ray optics designs for the future. The alternative designs require novel reflective substrates which are also discussed in the paper.

Lake trout population dynamics at Drummond Island Refuge in Lake Huron: Implications for future rehabilitation

USGS Publications Warehouse

Madenjian, C.P.; Ebener, M.P.; Desorcie, T.J.

2008-01-01

The Drummond Island Refuge (DIR) was established in 1985 as part of the rehabilitation effort for lake trout Salvelinus namaycush in Lake Huron. Since then, several strains of hatchery-reared lake trout have been stocked annually at the DIR. An intensive lampricide treatment of the St. Marys River during 1998-2001 was expected to lower the abundance of sea lamprey Petromyzon marinus within the DIR by 2000. We conducted annual gill-net surveys during spring and fall to evaluate the performance of each of the strains of lake trout as well as that of the entire lake trout population (all strains pooled) in the DIR during 1991-2005. The criteria to evaluate performance included the proportion of "wild" fish within the population, spawner density, adult survival, growth, maturity, and wounding rate by sea lampreys. Wild lake trout did not recruit to the adult population to any detectable degree. During 1991-2005, the average density of spawning lake trout appeared to be marginally sufficient to initiate a self-sustaining population. Survival of the Seneca Lake (SEN) strain of lake trout was significantly higher than that of the Superior-Marquette (SUP) strain, in part because of the higher sea-lamprey-induced mortality suffered by the SUP strain. However, other factors were also involved. Apparently SUP fish were more vulnerable to fishing conducted in waters near the refuge boundaries than SEN fish. The St. Marys River treatment appeared to be effective in reducing the sea lamprey wounding rate on SEN fish. We recommend that the stocking of SEN lake trout in the DIR, control of sea lampreys in the St. Marys River, and reduction of commercial fishery effort in waters near the DIR be maintained. ?? Copyright by the American Fisheries Society 2008.

Design and Evaluation of a new mechatronic platform for assessment and prevention of fall risks

PubMed Central

2012-01-01

Background Studying the responses in human behaviour to external perturbations during daily motor tasks is of key importance for understanding mechanisms of balance control and for investigating the functional response of targeted subjects. Experimental platforms as far developed entail a low number of perturbations and, only in few cases, have been designed to measure variables used at run time to trigger events during a certain motor task. Methods This work introduces a new mechatronic device, named SENLY, that provides balance perturbations while subjects carry out daily motor tasks (e.g., walking, upright stance). SENLY mainly consists of two independently-controlled treadmills that destabilize balance by suddenly perturbing belts movements in the horizontal plane. It is also provided with force sensors, which can be used at run time to estimate the ground reaction forces and identify events along the gait cycle in order to trigger the platform perturbation. The paper also describes the customized procedures adopted to calibrate the platform and the first testing trials aimed at evaluating its performance. Results SENLY allows to measure both vertical ground reaction forces and their related location more precisely and more accurately than other platforms of the same size. Moreover, the platform kinematic and kinetic performance meets all required specifications, with a negligible influence of the instrumental noise. Conclusion A new perturbing platform able to reproduce different slipping paradigms while measuring GRFs at run time in order to enable the asynchronous triggering during the gait cycle was designed and developed. Calibration procedures and pilot tests show that SENLY allows to suitably estimate dynamical features of the load and to standardize experimental sessions, improving the efficacy of functional analysis. PMID:22838638

Pregnancy Complications as Markers for Subsequent Maternal Cardiovascular Disease: Validation of a Maternal Recall Questionnaire

PubMed Central

Stuart, Jennifer J.; Farland, Leslie V.; Rich-Edwards, Janet W.; Zera, Chloe A.; McElrath, Thomas F.; Seely, Ellen W.

2015-01-01

Abstract Background: We designed and tested the validity of a questionnaire to characterize maternal recall of pregnancy complications associated with increased future cardiovascular disease risk, based on the 2011 American Heart Association (AHA) guidelines. Methods: A maternal recall questionnaire of pregnancy history was administered to 971 patients who had participated in a previous cohort study of 1,608 pregnant women. Medical records from the study pregnancy served as the gold standard. Prevalence, sensitivity (sens), specificity (spec), positive predictive value (PPV), negative predictive value (NPV), and/or Spearman's correlation coefficients (r) were calculated for each question. Results: A total of 526 (54%) individuals recontacted responded. Respondents were more likely to be older, white, educated, and nulliparous and were less likely to deliver low-birthweight infants in the study pregnancy than were individuals who did not respond. Mean length of recall was 4.35 years (standard deviation [SD] 0.46) postpartum. Maternal recall was most accurate for gestational diabetes (sens: 92%, spec: 98%, PPV: 79%, NPV: 99%), infant birthweight (r=0.95), and gestation length (r=0.85). Maternal recall was modest for preeclampsia (sens: 79%, spec: 97%, PPV: 68%, NPV: 98%) and pregnancy-associated hypertension, including preeclampsia or gestational hypertension (sens: 60%, spec: 95%, PPV: 64%, NPV: 94%). Conclusions: This validation study demonstrated that the majority of women could accurately recall a history of gestational diabetes, infant birthweight, and gestational age at delivery, 4 years postpartum on average. Recall of preeclampsia and pregnancy-associated hypertension overall was modest. Maternal report of these pregnancy conditions may help clinicians identify women at increased risk for cardiovascular disease. PMID:26061196

The role of N-terminal PRO-brain natriuretic peptide and echocardiography for screening asymptomatic left ventricular dysfunction in a population at high risk for heart failure. The PROBE-HF study.

PubMed

Betti, Irene; Castelli, Gabriele; Barchielli, Alessandro; Beligni, Cinzia; Boscherini, Vittorio; De Luca, Leonardo; Messeri, Gianni; Gheorghiade, Mihai; Maisel, Alan; Zuppiroli, Alfredo

2009-06-01

Screening for asymptomatic left ventricular dysfunction (ALVD) in subjects at risk for heart failure (HF) can affect clinical management. The aim of the present study is to examine the role of NT-pro BNP in the diagnosis of ALVD in subjects with hypertension and diabetes from primary care. A total of 1012 subjects with hypertension and/or diabetes and no symptoms or signs of HF were assessed by B-type natriuretic peptide (NT-proBNP) assay and echocardiography. Diastolic dysfunction was present in 368/1012 subjects (36.4%): 327 (32.4%) with mild diastolic dysfunction and 41 (4%) with a moderate-to-severe diastolic dysfunction. Systolic dysfunction was present in 11/1012 (1.1%). NT-proBNP levels were 170 +/- 206 and 859 +/- 661 pg/mL, respectively, in diastolic and systolic dysfunction and 92 +/- 169 in normal subjects (P < .0001). Pooling moderate-to-severe diastolic with systolic dysfunction, a total of 52 subjects (5.1 %) were obtained: best cutoff value of NT-proBNP was 125 pg/mL (males <67 years: sensitivity [Sens] 87.5%, specificity [Spec] 92.7%, negative predictive value [NPV] 99.5%, positive predictive value [PPV] 33.3%; females <67 years: Sens 100%, Spec 84.1%, NPV 100%, PPV 33.3%; males >or=67 years: Sens 100%, Spec 77.1%, NPV 100%, PPV 32.5%; females >or=67 years: Sens 100%, Spec 59.9%, NPV 100%, PPV 23%). The prevalence of ALVD in subjects at risk for HF is 5.1%. Because of its excellent NPV, NT-proBNP can be used by general practitioners to rule out ALVD in hypertensive or diabetic patients.

From the SAIN,LIM system to the SENS algorithm: a review of a French approach of nutrient profiling.

PubMed

Tharrey, Marion; Maillot, Matthieu; Azaïs-Braesco, Véronique; Darmon, Nicole

2017-08-01

Nutrient profiling aims to classify or rank foods according to their nutritional composition to assist policies aimed at improving the nutritional quality of foods and diets. The present paper reviews a French approach of nutrient profiling by describing the SAIN,LIM system and its evolution from its early draft to the simplified nutrition labelling system (SENS) algorithm. Considered in 2010 by WHO as the 'French model' of nutrient profiling, SAIN,LIM classifies foods into four classes based on two scores: a nutrient density score (NDS) called SAIN and a score of nutrients to limit called LIM, and one threshold on each score. The system was first developed by the French Food Standard Agency in 2008 in response to the European regulation on nutrition and health claims (European Commission (EC) 1924/2006) to determine foods that may be eligible for bearing claims. Recently, the European regulation (EC 1169/2011) on the provision of food information to consumers allowed simplified nutrition labelling to facilitate consumer information and help them make fully informed choices. In that context, the SAIN,LIM was adapted to obtain the SENS algorithm, a system able to rank foods for simplified nutrition labelling. The implementation of the algorithm followed a step-by-step, systematic, transparent and logical process where shortcomings of the SAIN,LIM were addressed by integrating specificities of food categories in the SENS, reducing the number of nutrients, ordering the four classes and introducing European reference intakes. Through the French example, this review shows how an existing nutrient profiling system can be specifically adapted to support public health nutrition policies.

Large deviation approach to the generalized random energy model

NASA Astrophysics Data System (ADS)

Dorlas, T. C.; Dukes, W. M. B.

2002-05-01

The generalized random energy model is a generalization of the random energy model introduced by Derrida to mimic the ultrametric structure of the Parisi solution of the Sherrington-Kirkpatrick model of a spin glass. It was solved exactly in two special cases by Derrida and Gardner. A complete solution for the thermodynamics in the general case was given by Capocaccia et al. Here we use large deviation theory to analyse the model in a very straightforward way. We also show that the variational expression for the free energy can be evaluated easily using the Cauchy-Schwarz inequality.

Replica Approach for Minimal Investment Risk with Cost

NASA Astrophysics Data System (ADS)

Shinzato, Takashi

2018-06-01

In the present work, the optimal portfolio minimizing the investment risk with cost is discussed analytically, where an objective function is constructed in terms of two negative aspects of investment, the risk and cost. We note the mathematical similarity between the Hamiltonian in the mean-variance model and the Hamiltonians in the Hopfield model and the Sherrington-Kirkpatrick model, show that we can analyze this portfolio optimization problem by using replica analysis, and derive the minimal investment risk with cost and the investment concentration of the optimal portfolio. Furthermore, we validate our proposed method through numerical simulations.

The Parisi Formula has a Unique Minimizer

NASA Astrophysics Data System (ADS)

Auffinger, Antonio; Chen, Wei-Kuo

2015-05-01

In 1979, Parisi (Phys Rev Lett 43:1754-1756, 1979) predicted a variational formula for the thermodynamic limit of the free energy in the Sherrington-Kirkpatrick model, and described the role played by its minimizer. This formula was verified in the seminal work of Talagrand (Ann Math 163(1):221-263, 2006) and later generalized to the mixed p-spin models by Panchenko (Ann Probab 42(3):946-958, 2014). In this paper, we prove that the minimizer in Parisi's formula is unique at any temperature and external field by establishing the strict convexity of the Parisi functional.

Innovative space x-ray telescopes

NASA Astrophysics Data System (ADS)

Hudec, R.; Inneman, A.; Pina, L.; Sveda, L.; Ticha, H.; Brozek, V.

2017-11-01

We report on the progress in innovative X-ray mirror development with focus on requirements of future X-ray astronomy space projects. Various future projects in X-ray astronomy and astrophysics will require large lightweight but highly accurate segments with multiple thin shells or foils. The large Wolter 1 grazing incidence multiple mirror arrays, the Kirkpatrick-Baez modules, as well as the large Lobster-Eye X-ray telescope modules in Schmidt arrangement may serve as examples. All these space projects will require high quality and light segmented shells (shaped, bent or flat foils) with high X-ray reflectivity and excellent mechanical stability.

Inverse Ising Inference Using All the Data

NASA Astrophysics Data System (ADS)

Aurell, Erik; Ekeberg, Magnus

2012-03-01

We show that a method based on logistic regression, using all the data, solves the inverse Ising problem far better than mean-field calculations relying only on sample pairwise correlation functions, while still computationally feasible for hundreds of nodes. The largest improvement in reconstruction occurs for strong interactions. Using two examples, a diluted Sherrington-Kirkpatrick model and a two-dimensional lattice, we also show that interaction topologies can be recovered from few samples with good accuracy and that the use of l1 regularization is beneficial in this process, pushing inference abilities further into low-temperature regimes.

The simplest possible design for a KB microfocus mirror system?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, S. P., E-mail: steve.collins@diamond.ac.uk; Scott, S. M.; Hawkins, D. M.

2016-07-27

We report a design for a Kirkpatrick-Baez (KB) microfocussing mirror system. The main components are described, with emphasis on a ‘tripod’ manipulator, where we outline the required coordinate transformation calculations. The merit of this device lies in its simplicity of design, minimal degrees of freedom, and speed and ease of setup on a beamline. Test results and an example of the mirrors in use on Diamond Beamline I16, showing a high-resolution polar domain map of KTiOPO{sub 4} with a spot size of 1.25 µm × 1.5 µm, are presented.

KSC-04PD-1560

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Sen. John F. Kerry (center), D-Mass., discusses Space Shuttle processing with NASA Vehicle Manager Stephanie Stilson during a tour of the Orbiter Processing Facility (OPF). They are standing under the orbiter Discovery, which is being prepared for flight on the next Space Shuttle mission. The tour follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes Americas commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

Residual Strength after Fatigue of Unidirectional and Cross-Ply Metal Matrix Composites at Elevated Temperature

DTIC Science & Technology

1996-06-01

MPO)SIT[lS A’l’ 1’IIVA tI , P R T 1R , ’[II?,I Scil.’’/e Cliou . Major, 1R. C ). 0’. ARMY AFIT/ GAE / ENY I 9(’ , 96-01650 DEPARTMENT OF THE AIR FORCE...UNIDIRECTIONAL AND CROSS-PLY METAL MATRIX COMPOSITES AT ELEVATED TEMPERATURE THESISp Sen-Tzcr Chiou, Major, R. 0. C ., ARMY AFIT GAE ENY 96 J-2 Approved for...for the Degree of’ Master of Sciene in Aeronautical Engince. ing Sen-Tzer ChioLu. Major, R. 0. C ., ARMY June, 1996 Approved for public release

KSC-04pd1560

NASA Image and Video Library

2004-07-26

KENNEDY SPACE CENTER, FLA. - Sen. John F. Kerry (center), D-Mass., discusses Space Shuttle processing with NASA Vehicle Manager Stephanie Stilson during a tour of the Orbiter Processing Facility (OPF). They are standing under the orbiter Discovery, which is being prepared for flight on the next Space Shuttle mission. The tour follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes America’s commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Maryland's Sen. Barbara Mikulski greeted employees at NASA's Goddard Space Flight Center in Greenbelt, Maryland, during a packed town hall meeting Jan. 6. She discussed her history with Goddard and appropriations for NASA in 2016. Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... Credit: NASA/Goddard/Rebecca Roth NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2016-01-06

Maryland's Sen. Barbara Mikulski greeted employees at NASA's Goddard Space Flight Center in Greenbelt, Maryland, during a packed town hall meeting Jan. 6. She discussed her history with Goddard and appropriations for NASA in 2016. Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... Credit: NASA/Goddard/Rebecca Roth NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Maryland's Sen. Barbara Mikulski greeted employees at NASA's Goddard Space Flight Center in Greenbelt, Maryland, during a packed town hall meeting Jan. 6. She discussed her history with Goddard and appropriations for NASA in 2016. Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... Credit: NASA/Goddard/Bill Hrybyk NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2016-01-06

Maryland's Sen. Barbara Mikulski greeted employees at NASA's Goddard Space Flight Center in Greenbelt, Maryland, during a packed town hall meeting Jan. 6. She discussed her history with Goddard and appropriations for NASA in 2016. Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... Credit: NASA/Goddard/Bill Hrybyk NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Reliability and Construct Validity of the SENS Motion® Activity Measurement System as a Tool to Detect Sedentary Behaviour in Patients with Knee Osteoarthritis

PubMed Central

Gudbergsen, Henrik; Kjærgaard, Morten; Lykkegaard, Kasper Lundberg

2018-01-01

Physical inactivity is important to address, and an objective way of measuring inactivity is by accelerometry. The objective of this study was to determine the reliability and construct validity of the SENS motion system to record physical activity and inactivity in patients with knee osteoarthritis. Participants with an age > 40 years and an average weekly pain above 0 on a numeric rating scale (0 = no pain, 10 = worst pain) were included. Participants had a total of two study visits and at each visit participants completed a standardized activity. Data from 24 participants were analysed. A mean agreement of 99% (SD 3%) for sedentary behaviour and a mean agreement of 97% (SD 9%) for active behaviour were found. The agreement for “walking” was 28% (SD 18%). Mean agreement between recordings on the two visits was 96% (SD 8%) for sedentary behaviour and 99% (SD 1%) for active behaviour. The SENS motion activity measurement system can be regarded as a reliable and valid device for measuring sedentary behaviour in patients with knee OA, whereas detection of walking is not reliable and would require further work. PMID:29686901

Optimization of performance parameters for large area silicon photomultipliers for use in the GlueX experiment

NASA Astrophysics Data System (ADS)

Janzen, Kathryn Louise

Largely because of their resistance to magnetic fields, silicon photomultipliers (SiPMs) are being considered as the readout for the GlueX Barrel Calorimeter, a key component of the GlueX detector located immediately inside a 2.2 T superconducting solenoid. SiPMs with active area 1 x 1 mm2 have been investigated for use in other experiments, but detectors with larger active areas are required for the GlueX BCAL. This puts the GlueX collaboration in the unique position of being pioneers in the use of this frontend detection revolution by driving the technology for larger area sensors. SensL, a photonics research and development company in Ireland, has been collaborating with the University of Regina GlueX group to develop prototype large area SiPMs comprising 16 - 3x3 mm2 cells assembled in a close-packed matrix. Performance parameters of individual SensL 1x1 mm2 and 3x3 mm2 SiPMs along with prototype SensL SiPM arrays are tested, including current versus voltage characteristics, photon detection efficiency, and gain uniformity, in an effort to determine the suitability of these detectors to the GlueX BCAL readout.

Evaluation of the RealTime HIV-1, Xpert HIV-1, and Aptima HIV-1 Quant Dx Assays in Comparison to the NucliSens EasyQ HIV-1 v2.0 Assay for Quantification of HIV-1 Viral Load.

PubMed

Mor, Orna; Gozlan, Yael; Wax, Marina; Mileguir, Fernando; Rakovsky, Avia; Noy, Bina; Mendelson, Ella; Levy, Itzchak

2015-11-01

HIV-1 RNA monitoring, both before and during antiretroviral therapy, is an integral part of HIV management worldwide. Measurements of HIV-1 viral loads are expected to assess the copy numbers of all common HIV-1 subtypes accurately and to be equally sensitive at different viral loads. In this study, we compared for the first time the performance of the NucliSens v2.0, RealTime HIV-1, Aptima HIV-1 Quant Dx, and Xpert HIV-1 viral load assays. Plasma samples (n = 404) were selected on the basis of their NucliSens v2.0 viral load results and HIV-1 subtypes. Concordance, linear regression, and Bland-Altman plots were assessed, and mixed-model analysis was utilized to compare the analytical performance of the assays for different HIV-1 subtypes and for low and high HIV-1 copy numbers. Overall, high concordance (>83.89%), high correlation values (Pearson r values of >0.89), and good agreement were observed among all assays, although the Xpert and Aptima assays, which provided the most similar outputs (estimated mean viral loads of 2.67 log copies/ml [95% confidence interval [CI], 2.50 to 2.84 log copies/ml] and 2.68 log copies/ml [95% CI, 2.49 to 2.86 log copies/ml], respectively), correlated best with the RealTime assay (89.8% concordance, with Pearson r values of 0.97 to 0.98). These three assays exhibited greater precision than the NucliSens v2.0 assay. All assays were equally sensitive for subtype B and AG/G samples and for samples with viral loads of 1.60 to 3.00 log copies/ml. The NucliSens v2.0 assay underestimated A1 samples and those with viral loads of >3.00 log copies/ml. The RealTime assay tended to underquantify subtype C (compared to the Xpert and Aptima assays) and subtype A1 samples. The Xpert and Aptima assays were equally efficient for detection of all subtypes and viral loads, which renders these new assays most suitable for clinical HIV laboratories. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Insights into the reproduction of some Antarctic dendroceratid, poecilosclerid, and haplosclerid demosponges

PubMed Central

Koutsouveli, Vasiliki; Taboada, Sergi; Moles, Juan; Cristobo, Javier; Ríos, Pilar; Bertran, Andrea; Solà, Joan; Avila, Conxita

2018-01-01

Sponges are a dominant element of the Antarctic benthic communities, posing both high species richness and large population densities. Despite their importance in Antarctic ecosystems, very little is known about their reproductive patterns and strategies. In our study, we surveyed the tissue of six different species for reproductive elements, namely, Dendrilla antarctica Topsent, 1905 (order Dendroceratida), Phorbas areolatus (Thiele, 1905), Kirkpatrickia variolosa (Kirkpatrick, 1907), and Isodictya kerguelenensis (Ridley & Dendy, 1886) (order Poecilosclerida), and Hemigellius pilosus (Kirkpatrick, 1907) and Haliclona penicillata (Topsent, 1908) (Haplosclerida). Samples of these six species containing various reproductive elements were collected in Deception Island and were processed for both light and transmission electron microscopy (TEM). Even though we were not able to monitor the entire reproductive cycle, due to time and meteorological conditions, we report important aspects of the reproduction of these species. This includes oocyte and embryo morphology and cell ultrastructure, follicular structures and nurse cell activity, as well as vitellogenesis. All species were brooding their embryos within their mesohyl. Both oocytes and embryos were registered in the majority of the studied species, and a single sperm cell being carried to an egg for fertilization was observed in H. penicillata. While the reproductive periods of all species coincided temporally, some of them seemed to rely on a single spawning event, this being suggested by the synchronic oogenesis and embryogenesis occurrence of D. antarctica, P. areolatus and I. kerguelenensis. In contrast, K. variolosa had an asynchronous embryo development, which suggests several larval release events. Our results suggest that differences in the reproductive strategies and morphological traits might succeed in the coexistence of these species at the same habitat avoiding the direct competition between them. PMID:29420669

Evaluation of a training program of hypertension for accredited social health activists (ASHA) in rural India.

PubMed

Abdel-All, Marwa; Thrift, Amanda Gay; Riddell, Michaela; Thankappan, Kavumpurathu Raman Thankappan; Mini, Gomathyamma Krishnakurup; Chow, Clara K; Maulik, Pallab Kumar; Mahal, Ajay; Guggilla, Rama; Kalyanram, Kartik; Kartik, Kamakshi; Suresh, Oduru; Evans, Roger George; Oldenburg, Brian; Thomas, Nihal; Joshi, Rohina

2018-05-02

Hypertension is a major risk factor for cardiovascular disease, a leading cause of premature death and disability in India. Since access to health services is poor in rural India and Accredited Social Health Activists (ASHAs) are available throughout India for maternal and child health, a potential solution for improving hypertension control is by utilising this available workforce. We aimed to develop and implement a training package for ASHAs to identify and control hypertension in the community, and evaluate the effectiveness of the training program using the Kirkpatrick Evaluation Model. The training program was part of a cluster randomised feasibility trial of a 3-month intervention to improve hypertension outcomes in South India. Training materials incorporated details on managing hypertension, goal setting, facilitating group meetings, and how to measure blood pressure and weight. The 15 ASHAs attended a five-day training workshop that was delivered using interactive instructional strategies. ASHAs then led community-based education support groups for 3 months. Training was evaluated using Kirkpatrick's evaluation model for measuring reactions, learning, behaviour and results using tests on knowledge at baseline, post-training and post-intervention, observation of performance during meetings and post-intervention interviews. The ASHAs' knowledge of hypertension improved from a mean score of 64% at baseline to 76% post-training and 84% after the 3-month intervention. Research officers, who observed the community meetings, reported that ASHAs delivered the self-management content effectively without additional assistance. The ASHAs reported that the training materials were easy to understand and useful in educating community members. ASHAs can be trained to lead community-based group educational discussions and support individuals for the management of high blood pressure. The feasibility trial is registered with the Clinical Trials Registry - India (CTRI) CTRI/2016/02/006678 (25/02/2016).

Sensitivity, specificity, positive and negative predictive values: diagnosing purple mange.

PubMed

Collier, Jill; Huebscher, Roxana

2010-04-01

To shed light on several epidemiological terms for better understanding of diagnostic testing measures by using a mythical condition, "purple mange." Scientific literature related to epidemiology and statistical tests. Nurse practitioners (NPs) use the concepts of sensitivity (SEN), specificity (SPEC), positive predictive value (PPV), and negative predictive value (NPV) daily in primary care and specialty areas. In addition, PPV and NPV vary with the prevalence of a condition. At times, NPs misunderstand the meaning of these terms. In order to develop appropriate treatment plans, an understanding of the concepts of SEN, SPEC, PPV, and NPV is important for interpreting test results. The authors have used this mythical condition purple mange as a teaching tool for NP students.

senator-barbara-mikulski-visits-nasa-goddard_23847927479_o

NASA Image and Video Library

2016-01-06

Maryland's Sen. Barbara Mikulski greeted employees at NASA's Goddard Space Flight Center in Greenbelt, Maryland, during a packed town hall meeting Jan. 6. She discussed her history with Goddard and appropriations for NASA in 2016. Read more: http://www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mikulski-visits-nasa-goddard Credit: NASA/Goddard/Rebecca Roth NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram   N

Senator Barbara Mikulski visits NASA Goddard Space Flight Center.

NASA Image and Video Library

2016-01-06

Maryland's Sen. Barbara Mikulski greeted employees at NASA's Goddard Space Flight Center in Greenbelt, Maryland, during a packed town hall meeting Jan. 6. She discussed her history with Goddard and appropriations for NASA in 2016. Read more: http://www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mikulski-visits-nasa-goddard Credit: NASA/Goddard/Rebecca Roth NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram   N

senator-barbara-mikulski-visits-nasa-goddard_24107702312_o

NASA Image and Video Library

2016-01-06

Maryland's Sen. Barbara Mikulski greeted employees at NASA's Goddard Space Flight Center in Greenbelt, Maryland, during a packed town hall meeting Jan. 6. She discussed her history with Goddard and appropriations for NASA in 2016. Read more: http://www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mikulski-visits-nasa-goddard Credit: NASA/Goddard/Rebecca Roth NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram   N

Work productivity in rheumatoid arthritis: relationship with clinical and radiological features.

PubMed

Chaparro Del Moral, Rafael; Rillo, Oscar Luis; Casalla, Luciana; Morón, Carolina Bru; Citera, Gustavo; Cocco, José A Maldonado; Correa, María de Los Ángeles; Buschiazzo, Emilio; Tamborenea, Natalia; Mysler, Eduardo; Tate, Guillermo; Baños, Andrea; Herscovich, Natalia

2012-01-01

Objective. To assess the relationship between work productivity with disease activity, functional capacity, life quality and radiological damage in patients with rheumatoid arthritis (RA). Methods. The study included consecutive employed patients with RA (ACR'87), aged over 18. Demographic, disease-related, and work-related variables were determined. The reduction of work productivity was assessed by WPAI-RA. Results. 90 patients were evaluated, 71% women. Age average is 50 years old, DAS28 4, and RAQoL 12. Median SENS is 18 and HAQ-A 0.87. Mean absenteeism was of 14%, presenting an average of 6.30 work hours wasted weekly. The reduction in performance at work or assistance was of 38.4% and the waste of productivity was of 45%. Assistance correlated with DAS28 (r = 0.446; P < 0.001), HAQ-A (r = 0.545; P < 0.001) and RAQoL (r = 0.475; P < 0.001). Lower total productivity was noticed in higher levels of activity and functional disability. Patients with SENS > 18 showed lower work productivity than those with SENS < 18 (50 versus 34; P = 0.04). In multiple regression analysis, variables associated with reduction of total work productivity were HAQ-A and RAQoL. Conclusion. RA patients with higher disease severity showed higher work productivity compromise.

Work Productivity in Rheumatoid Arthritis: Relationship with Clinical and Radiological Features

PubMed Central

Chaparro del Moral, Rafael; Rillo, Oscar Luis; Casalla, Luciana; Morón, Carolina Bru; Citera, Gustavo; Cocco, José A. Maldonado; Correa, María de los Ángeles; Buschiazzo, Emilio; Tamborenea, Natalia; Mysler, Eduardo; Tate, Guillermo; Baños, Andrea; Herscovich, Natalia

2012-01-01

Objective. To assess the relationship between work productivity with disease activity, functional capacity, life quality and radiological damage in patients with rheumatoid arthritis (RA). Methods. The study included consecutive employed patients with RA (ACR'87), aged over 18. Demographic, disease-related, and work-related variables were determined. The reduction of work productivity was assessed by WPAI-RA. Results. 90 patients were evaluated, 71% women. Age average is 50 years old, DAS28 4, and RAQoL 12. Median SENS is 18 and HAQ-A 0.87. Mean absenteeism was of 14%, presenting an average of 6.30 work hours wasted weekly. The reduction in performance at work or assistance was of 38.4% and the waste of productivity was of 45%. Assistance correlated with DAS28 (r = 0.446; P < 0.001), HAQ-A (r = 0.545; P < 0.001) and RAQoL (r = 0.475; P < 0.001). Lower total productivity was noticed in higher levels of activity and functional disability. Patients with SENS > 18 showed lower work productivity than those with SENS < 18 (50 versus 34; P = 0.04). In multiple regression analysis, variables associated with reduction of total work productivity were HAQ-A and RAQoL. Conclusion. RA patients with higher disease severity showed higher work productivity compromise. PMID:23320166

A glucose meter evaluation co-designed with both health professional and consumer input.

PubMed

Thompson, Harmony; Chan, Huan; Logan, Florence J; Heenan, Helen F; Taylor, Lynne; Murray, Chris; Florkowski, Christopher M; Frampton, Christopher M A; Lunt, Helen

2013-11-22

Health consumer's input into assessment of medical device safety is traditionally given either as part of study outcome (trial participants) or during post marketing surveillance. Direct consumer input into the methodological design of device assessment is less common. We discuss the difference in requirements for assessment of a measuring device from the consumer and clinician perspectives, using the example of hand held glucose meters. Around 80,000 New Zealanders with diabetes recently changed their glucose meter system, to enable ongoing access to PHARMAC subsidised meters and strips. Consumers were most interested in a direct comparison of their 'old' meter system (Accu-Chek Performa) with their 'new' meter system (CareSens brand, including the CareSens N POP), rather than comparisons against a laboratory standard. This direct comparison of meter/strip systems showed that the CareSens N POP meter read around 0.6 mmol/L higher than the Performa system. Whilst this difference is unlikely to result in major errors in clinical decision making such as major insulin dosing errors, this information is nevertheless of interest to consumers who switched meters so that they could maintain access to PHARMAC subsidised meters and strips. We recommend that when practical, the consumer perspective be incorporated into study design related to medical device assessment.

Inside-in, alternative paradigms for sound spatialization

NASA Astrophysics Data System (ADS)

Bahn, Curtis; Moore, Stephan

2003-04-01

Arrays of widely spaced mono-directional loudspeakers (P.A.-style stereo configurations or ``outside-in'' surround-sound systems) have long provided the dominant paradigms for electronic sound diffusion. So prevalent are these models that alternatives have largely been ignored and electronic sound, regardless of musical aesthetic, has come to be inseparably associated with single-channel speakers, or headphones. We recognize the value of these familiar paradigms, but believe that electronic sound can and should have many alternative, idiosyncratic voices. Through the design and construction of unique sound diffusion structures, one can reinvent the nature of electronic sound; when allied with new sensor technologies, these structures offer alternative modes of interaction with techniques of sonic computation. This paper describes several recent applications of spherical speakers (multichannel, outward-radiating geodesic speaker arrays) and Sensor-Speaker-Arrays (SenSAs: combinations of various sensor devices with outward-radiating multi-channel speaker arrays). This presentation introduces the development of four generations of spherical speakers-over a hundred individual speakers of various configurations-and their use in many different musical situations including live performance, recording, and sound installation. We describe the design and construction of these systems, and, more generally, the new ``voices'' they give to electronic sound.

Armored Enzyme Nanoparticles for Remediation of Subsurface Contaminants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jonathan S. Dordick; Jay Grate; Jungbae Kim

2007-02-19

The remediation of subsurface contaminants is a critical problem for the Department of Energy, other government agencies, and our nation. Severe contamination of soil and groundwater exists at several DOE sites due to various methods of intentional and unintentional release. Given the difficulties involved in conventional removal or separation processes, it is vital to develop methods to transform contaminants and contaminated earth/water to reduce risks to human health and the environment. Transformation of the contaminants themselves may involve conversion to other immobile species that do not migrate into well water or surface waters, as is proposed for metals and radionuclides;more » or degradation to harmless molecules, as is desired for organic contaminants. Transformation of contaminated earth (as opposed to the contaminants themselves) may entail reductions in volume or release of bound contaminants for remediation. Research at Rensselaer focused on the development of haloalkane dehalogenase as a critical enzyme in the dehalogenation of contaminated materials (ultimately trichloroethylene and related pollutants). A combination of bioinformatic investigation and experimental work was performed. The bioinformatics was focused on identifying a range of dehalogenase enzymes that could be obtained from the known proteomes of major microorganisms. This work identified several candidate enzymes that could be obtained through relatively straightforward gene cloning and expression approaches. The experimental work focused on the isolation of haloalkane dehalogenase from a Xanthobacter species followed by incorporating the enzyme into silicates to form biocatalytic silicates. These are the precursors of SENs. At the conclusion of the study, dehalogenase was incorporated into SENs, although the loading was low. This work supported a single Ph.D. student (Ms. Philippa Reeder) for two years. The project ended prior to her being able to perform substantive bioinformatics efforts that would identify more promising dehalogenase enzymes. The SEN synthesis, however, was demonstrated to be partially successful with dehalogenases. Further work would provide optimized dehalogenases in SENs for use in pollution remission.« less

Performance of prenatal screening using maternal serum and ultrasound markers for Down syndrome in Chinese women: a systematic review and meta-analysis.

PubMed

Tu, S; Rosenthal, M; Wang, D; Huang, J; Chen, Y

2016-09-01

Controversies about the performance of conventional prenatal screening using maternal serum and ultrasound markers (PSMSUM) in detecting Down syndrome (DS) have been raised as a result of a recently available noninvasive prenatal test based on cell-free fetal DNA sequencing. To evaluate the screening performance of PSMSUM in detecting DS in Chinese women. An exhaustive literature search of MEDLINE, Embase, the Cochrane Library, ISI Web of Science and China BioMedical Disc. Primary studies, published from January 2004 to November 2014, which examined the screening accuracy of PSMSUM in pregnant Chinese women, compared with a reference standard, either chromosomal verification or inspection of the newborn. Data were extracted as screening positive/negative results for Down and non-Down syndrome pregnancies, allowing estimation of sensitivities and specificities. Risks of bias within and across studies were assessed. Screening accuracy measures were pooled using a bivariate random effects regression model. Seventy-eight studies, involving six categories of PSMSUM, were included. Second-trimester double serum [pooled sensitivity (SEN) = 0.80, pooled specificity (SPE) = 0.95] and triple-serum (pooled SEN = 0.79, pooled SPE = 0.96) screening were the predominant PSMSUM methods. The screening performances of these methods achieved the national standard but varied enormously across studies. First-trimester combined screening (pooled SEN = 0.92, pooled SPE = 0.93) and second-trimester quadruple serum screening (median SEN = 0.86, median SPE = 0.96) performed better, but were rarely used. Second-trimester maternal serum screening has the potential to achieve satisfactory screening performance in middle- and low-income countries. The reported enormous range in screening performance of second-trimester PSMSUM calls for urgent implementation of methods for performance optimization. Meta-analysis results show good accuracy of maternal serum and ultrasound screening for trisomy 21 in Chinese women. © 2016 Royal College of Obstetricians and Gynaecologists.

Thermodynamical Limit for Correlated Gaussian Random Energy Models

NASA Astrophysics Data System (ADS)

Contucci, P.; Esposti, M. Degli; Giardinà, C.; Graffi, S.

Let {EΣ(N)}ΣΣN be a family of |ΣN|=2N centered unit Gaussian random variables defined by the covariance matrix CN of elements cN(Σ,τ):=Av(EΣ(N)Eτ(N)) and the corresponding random Hamiltonian. Then the quenched thermodynamical limit exists if, for every decomposition N=N1+N2, and all pairs (Σ,τ)ΣN×ΣN: where πk(Σ),k=1,2 are the projections of ΣΣN into ΣNk. The condition is explicitly verified for the Sherrington-Kirkpatrick, the even p-spin, the Derrida REM and the Derrida-Gardner GREM models.

Astronomer to Data Scientist

NASA Astrophysics Data System (ADS)

Kirkpatrick, Jessica

2015-01-01

Jessica Kirkpatrick received her PhD in Astrophysics from Berkeley in 2012. After an exhaustive job search within academia and beyond, she accepted a job as a data scientist / analyst for the social network Yammer (acquired by Microsoft) and is now the Director of Data Science for Education Company InstaEDU. Now instead of spending her days finding patterns in the large scale structure of galaxies, she finds patterns in the behaviors of people. She'll talk about her transition from astrophysics to tech, compare and contrast the two fields, and give tips about how to land a tech job, and discuss useful tools which helped her with her transition.

The X-ray Fluorescence Microscopy Beamline at the Australian Synchrotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paterson, D.; Jonge, M. D. de; Howard, D. L.

2011-09-09

A hard x-ray micro-nanoprobe has commenced operation at the Australian Synchrotron providing versatile x-ray fluorescence microscopy across an incident energy range from 4 to 25 keV. Two x-ray probes are used to collect {mu}-XRF and {mu}-XANES for elemental and chemical microanalysis: a Kirkpatrick-Baez mirror microprobe for micron resolution studies and a Fresnel zone plate nanoprobe capable of 60-nm resolution. Some unique aspects of the beamline design and operation are discussed. An advanced energy dispersive x-ray fluorescence detection scheme named Maia has been developed for the beamline, which enables ultrafast x-ray fluorescence microscopy.

Various views of STS-95 Senator John Glenn during training

NASA Image and Video Library

1998-06-18

S98-08741 (May 1998) --- Three crew members in training for the STS-95 mission check out a training version of a blood centrifuge that will accompany them aboard the Space Shuttle Discovery later this year. In the foreground (from the left), are astronauts Scott E. Parazynski and Pedro Duque, both mission specialists, and U.S. Sen. John H. Glenn Jr., payload specialist. Duque, representing the European Space Agency (ESA), has his right hand on the centrifuge. Sen. Glenn holds a vial of blood that would be placed inside the centrifuge. Among those in the background is astronaut Stephen K. Robinson (left side of frame), STS-95 mission specialist. The photo was taken by Joe McNally, National Geographic, for NASA.

KSC-04PD-1564

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Sen. John F. Kerry, D-Mass., visits the flight deck of Space Shuttle Discovery during a tour of the Orbiter Processing Facility (OPF). The bunny suit he is wearing is clean room attire required for anyone coming in close proximity to Discovery, currently being prepared for flight on the next Space Shuttle mission. The tour of the OPF follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes Americas commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

KSC-04pd1564

NASA Image and Video Library

2004-07-26

KENNEDY SPACE CENTER, FLA. - Sen. John F. Kerry, D-Mass., visits the flight deck of Space Shuttle Discovery during a tour of the Orbiter Processing Facility (OPF). The “bunny suit” he is wearing is clean room attire required for anyone coming in close proximity to Discovery, currently being prepared for flight on the next Space Shuttle mission. The tour of the OPF follows a public meeting Kerry held at the Dr. Kurt H. Debus Conference Facility at the Kennedy Space Center Visitor Complex. He said he chose to speak at KSC because it symbolizes America’s commitment to science, innovation and technology. He and Sen. John Edwards, D-N.C., are on a speaking tour prior to their appearance at the Democratic National Convention in Boston.

U-shaped, double-tapered, fiber-optic sensor for effective biofilm growth monitoring.

PubMed

Zhong, Nianbing; Zhao, Mingfu; Li, Yishan

2016-02-01

To monitor biofilm growth on polydimethylsiloxane in a photobioreactor effectively, the biofilm cells and liquids were separated and measured using a sensor with two U-shaped, double-tapered, fiber-optic probes (Sen. and Ref. probes). The probes' Au-coated hemispherical tips enabled double-pass evanescent field absorption. The Sen. probe sensed the cells and liquids inside the biofilm. The polyimide-silica hybrid-film-coated Ref. probe separated the liquids from the biofilm cells and analyzed the liquid concentration. The biofilm structure and active biomass were also examined to confirm the effectiveness of the measurement using a simulation model. The sensor was found to effectively respond to the biofilm growth in the adsorption through exponential phases at thicknesses of 0-536 μm.

NIL fabrication of a polymer-based photonic sensor device in P3SENS project

NASA Astrophysics Data System (ADS)

Giannone, Domenico; Dortu, Fabian; Bernier, Damien; Johnson, Nigel P.; Sharp, Graham J.; Hou, Lianping; Khokhar, Ali Z.; Fürjes, Péter; Kurunczi, Sándor; Petrik, Peter; Horvath, Robert; Aalto, Timo; Kolari, Kai; Ylinen, Sami; Haatainen, Tomi; Egger, Holger

2012-06-01

We present the most recent results of EU funded project P3SENS (FP7-ICT-2009.3.8) aimed at the development of a low-cost and medium sensitivity polymer based photonic biosensor for point of care applications in proteomics. The fabrication of the polymer photonic chip (biosensor) using thermal nanoimprint lithography (NIL) is described. This technique offers the potential for very large production at reduced cost. However several technical challenges arise due to the properties of the used materials. We believe that, once the NIL technique has been optimised to the specific materials, it could be even transferred to a kind of roll-to-roll production for manufacturing a very large number of photonic devices at reduced cost.

Effectiveness of a Web-Based Simulation in Improving Nurses' Workplace Practice With Deteriorating Ward Patients: A Pre- and Postintervention Study.

PubMed

Liaw, Sok Ying; Wong, Lai Fun; Lim, Eunice Ya Ping; Ang, Sophia Bee Leng; Mujumdar, Sandhya; Ho, Jasmine Tze Yin; Mordiffi, Siti Zubaidah; Ang, Emily Neo Kim

2016-02-19

Nurses play an important role in detecting patients with clinical deterioration. However, the problem of nurses failing to trigger deteriorating ward patients still persists despite the implementation of a patient safety initiative, the Rapid Response System. A Web-based simulation was developed to enhance nurses' role in recognizing and responding to deteriorating patients. While studies have evaluated the effectiveness of the Web-based simulation on nurses' clinical performance in a simulated environment, no study has examined its impact on nurses' actual practice in the clinical setting. The objective of this study was to evaluate the impact of Web-based simulation on nurses' recognition of and response to deteriorating patients in clinical settings. The outcomes were measured across all levels of Kirkpatrick's 4-level evaluation model with clinical outcome on triggering rates of deteriorating patients as the primary outcome measure. A before-and-after study was conducted on two general wards at an acute care tertiary hospital over a 14-month period. All nurses from the two study wards who undertook the Web-based simulation as part of their continuing nursing education were invited to complete questionnaires at various time points to measure their motivational reaction, knowledge, and perceived transfer of learning. Clinical records on cases triggered by ward nurses from the two study wards were evaluated for frequency and types of triggers over a period of 6 months pre- and 6 months postintervention. The number of deteriorating patients triggered by ward nurses in a medical general ward increased significantly (P<.001) from pre- (84/937, 8.96%) to postintervention (91/624, 14.58%). The nurses reported positively on the transfer of learning (mean 3.89, SD 0.49) from the Web-based simulation to clinical practice. A significant increase (P<.001) on knowledge posttest score from pretest score was also reported. The nurses also perceived positively their motivation (mean 3.78, SD 0.56) to engage in the Web-based simulation. This study provides evidence on the effectiveness of Web-based simulation in improving nursing practice when recognizing and responding to deteriorating patients. This educational tool could be implemented by nurse educators worldwide to address the educational needs of a large group of hospital nurses responsible for patients in clinical deterioration.

Cooperation between two periplasmic copper chaperones is required for full activity of the cbb 3-type cytochrome c oxidase and copper homeostasis in Rhodobacter capsulatus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trasnea, Petru -Iulian; Utz, Marcel; Khalfaoui-Hassani, Bahia

Copper (Cu) is an essential micronutrient that functions as a cofactor in several important enzymes, like respiratory heme-copper oxygen reductases. Yet, Cu is also toxic and therefore cells engage a highly coordinated Cu uptake and delivery system to prevent the accumulation of toxic Cu concentrations. In the current work we analyzed Cu delivery to the cbb 3-type cytochrome c oxidase ( cbb 3-Cox) of Rhodobacter capsulatus. We identified the PCu AC-like periplasmic chaperone PccA and analyzed its contribution to cbb 3-Cox assembly. Our data demonstrate that PccA is a Cu-binding protein with a preference for Cu(I), which is required formore » efficient cbb 3-Cox assembly, in particular at low Cu concentrations. By using in vivo and in vitro crosslinking we show that PccA forms a complex with the Sco1-homologue SenC. This complex is stabilized in the absence of the cbb 3-Cox specific assembly factors CcoGHIS. In cells lacking SenC, the cytoplasmic Cu content is significantly increased, but the simultaneous absence of PccA prevents this Cu accumulation. Lastly, these data demonstrate that the interplay between PccA and SenC is not only required for Cu delivery during cbb 3-Cox assembly, but that it also regulates Cu homeostasis in R. capsulatus.« less

Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assays.

PubMed

Macmillan, Donna S; Canipa, Steven J; Chilton, Martyn L; Williams, Richard V; Barber, Christopher G

2016-04-01

There is a pressing need for non-animal methods to predict skin sensitisation potential and a number of in chemico and in vitro assays have been designed with this in mind. However, some compounds can fall outside the applicability domain of these in chemico/in vitro assays and may not be predicted accurately. Rule-based in silico models such as Derek Nexus are expert-derived from animal and/or human data and the mechanism-based alert domain can take a number of factors into account (e.g. abiotic/biotic activation). Therefore, Derek Nexus may be able to predict for compounds outside the applicability domain of in chemico/in vitro assays. To this end, an integrated testing strategy (ITS) decision tree using Derek Nexus and a maximum of two assays (from DPRA, KeratinoSens, LuSens, h-CLAT and U-SENS) was developed. Generally, the decision tree improved upon other ITS evaluated in this study with positive and negative predictivity calculated as 86% and 81%, respectively. Our results demonstrate that an ITS using an in silico model such as Derek Nexus with a maximum of two in chemico/in vitro assays can predict the sensitising potential of a number of chemicals, including those outside the applicability domain of existing non-animal assays. Copyright © 2016 Elsevier Inc. All rights reserved.

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office. Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Bill Hrybyk Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office. Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. In this image, a gathering of Goddard employees watch the ribbon cutting. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Desiree Stover Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office. Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Chris Gunn Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office. Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm (visible at top right), a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Bill Hrybyk Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2016-01-06

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office. Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... Credit: NASA/Goddard/Chris Gunn NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office (SSCO). Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm (visible above, at right), a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Desiree Stover Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Cooperation between two periplasmic copper chaperones is required for full activity of the cbb 3-type cytochrome c oxidase and copper homeostasis in Rhodobacter capsulatus

DOE PAGES

Trasnea, Petru -Iulian; Utz, Marcel; Khalfaoui-Hassani, Bahia; ...

2016-02-28

Copper (Cu) is an essential micronutrient that functions as a cofactor in several important enzymes, like respiratory heme-copper oxygen reductases. Yet, Cu is also toxic and therefore cells engage a highly coordinated Cu uptake and delivery system to prevent the accumulation of toxic Cu concentrations. In the current work we analyzed Cu delivery to the cbb 3-type cytochrome c oxidase ( cbb 3-Cox) of Rhodobacter capsulatus. We identified the PCu AC-like periplasmic chaperone PccA and analyzed its contribution to cbb 3-Cox assembly. Our data demonstrate that PccA is a Cu-binding protein with a preference for Cu(I), which is required formore » efficient cbb 3-Cox assembly, in particular at low Cu concentrations. By using in vivo and in vitro crosslinking we show that PccA forms a complex with the Sco1-homologue SenC. This complex is stabilized in the absence of the cbb 3-Cox specific assembly factors CcoGHIS. In cells lacking SenC, the cytoplasmic Cu content is significantly increased, but the simultaneous absence of PccA prevents this Cu accumulation. Lastly, these data demonstrate that the interplay between PccA and SenC is not only required for Cu delivery during cbb 3-Cox assembly, but that it also regulates Cu homeostasis in R. capsulatus.« less

Statistical characterization of the standard map

NASA Astrophysics Data System (ADS)

Ruiz, Guiomar; Tirnakli, Ugur; Borges, Ernesto P.; Tsallis, Constantino

2017-06-01

The standard map, paradigmatic conservative system in the (x, p) phase space, has been recently shown (Tirnakli and Borges (2016 Sci. Rep. 6 23644)) to exhibit interesting statistical behaviors directly related to the value of the standard map external parameter K. A comprehensive statistical numerical description is achieved in the present paper. More precisely, for large values of K (e.g. K  =  10) where the Lyapunov exponents are neatly positive over virtually the entire phase space consistently with Boltzmann-Gibbs (BG) statistics, we verify that the q-generalized indices related to the entropy production q{ent} , the sensitivity to initial conditions q{sen} , the distribution of a time-averaged (over successive iterations) phase-space coordinate q{stat} , and the relaxation to the equilibrium final state q{rel} , collapse onto a fixed point, i.e. q{ent}=q{sen}=q{stat}=q{rel}=1 . In remarkable contrast, for small values of K (e.g. K  =  0.2) where the Lyapunov exponents are virtually zero over the entire phase space, we verify q{ent}=q{sen}=0 , q{stat} ≃ 1.935 , and q{rel} ≃1.4 . The situation corresponding to intermediate values of K, where both stable orbits and a chaotic sea are present, is discussed as well. The present results transparently illustrate when BG behavior and/or q-statistical behavior are observed.

Multivariate Models for Prediction of Human Skin Sensitization ...

EPA Pesticide Factsheets

One of the lnteragency Coordinating Committee on the Validation of Alternative Method's (ICCVAM) top priorities is the development and evaluation of non-animal approaches to identify potential skin sensitizers. The complexity of biological events necessary to produce skin sensitization suggests that no single alternative method will replace the currently accepted animal tests. ICCVAM is evaluating an integrated approach to testing and assessment based on the adverse outcome pathway for skin sensitization that uses machine learning approaches to predict human skin sensitization hazard. We combined data from three in chemico or in vitro assays - the direct peptide reactivity assay (DPRA), human cell line activation test (h-CLAT) and KeratinoSens TM assay - six physicochemical properties and an in silico read-across prediction of skin sensitization hazard into 12 variable groups. The variable groups were evaluated using two machine learning approaches , logistic regression and support vector machine, to predict human skin sensitization hazard. Models were trained on 72 substances and tested on an external set of 24 substances. The six models (three logistic regression and three support vector machine) with the highest accuracy (92%) used: (1) DPRA, h-CLAT and read-across; (2) DPRA, h-CLAT, read-across and KeratinoSens; or (3) DPRA, h-CLAT, read-across, KeratinoSens and log P. The models performed better at predicting human skin sensitization hazard than the murine

Self-interest and the theory of action.

PubMed

Barbalet, Jack

2012-09-01

The concept of self-interest remains underdeveloped in sociology although central to economics. Recent methodological and social trends render sociological indifference to the concept untenable. The term has enjoyed historical predominance in the West since the sixteenth century. While it is seen in modern economics as a singular motivating force, Adam Smith regarded self-interest in economic action as necessarily moderated by sympathy. In addition to its problematic economic conceptualization self-interest has an experiential basis in unequal power relations. An alternative to the concept of self-interest is presented by Amartya Sen in his account of commitment; its inconsistencies, however, render Sen's statement unsatisfactory. Differences between present and future interests indicate that the distinction between self-interested and other-interested action is not sustainable. © London School of Economics and Political Science 2012.

A-3 Groundbreaking Ceremony

NASA Image and Video Library

2007-08-23

NASA officials and government leaders participated in a groundbreaking event for a new rocket engine test stand at NASA's Stennis Space Center, Miss. Pictured (left to right) are Deputy Associate Administrator for Exploration Systems Doug Cooke, Pratt & Whitney Rocketdyne President Jim Maser, Stennis Space Center Director Richard Gilbrech, NASA Associate Administrator for Exploration Systems Scott Horowitz, NASA Deputy Administrator Shana Dale, Mississippi Gov. Haley Barbour, Sen. Thad Cochran, Sen. Trent Lott, Rep. Gene Taylor, SSC's Deputy Director Gene Goldman, and SSC's A-3 Project Manager Lonnie Dutreix. Stennis' A-3 Test Stand will provide altitude testing for NASA's developing J-2X engine. That engine will power the upper stages of NASA's Ares I and Ares V rockets. A-3 is the first large test stand to be built at SSC since the site's inception in the 1960s.

U-shaped, double-tapered, fiber-optic sensor for effective biofilm growth monitoring

PubMed Central

Zhong, Nianbing; Zhao, Mingfu; Li, Yishan

2016-01-01

To monitor biofilm growth on polydimethylsiloxane in a photobioreactor effectively, the biofilm cells and liquids were separated and measured using a sensor with two U-shaped, double-tapered, fiber-optic probes (Sen. and Ref. probes). The probes’ Au-coated hemispherical tips enabled double-pass evanescent field absorption. The Sen. probe sensed the cells and liquids inside the biofilm. The polyimide–silica hybrid-film-coated Ref. probe separated the liquids from the biofilm cells and analyzed the liquid concentration. The biofilm structure and active biomass were also examined to confirm the effectiveness of the measurement using a simulation model. The sensor was found to effectively respond to the biofilm growth in the adsorption through exponential phases at thicknesses of 0–536 μm. PMID:26977344

A Scoping Review of Peer-led Education in Patient Safety Training

PubMed Central

McLachlan, Andrew J.; Chen, Timothy F.

2018-01-01

Objective. To examine the literature pertaining to the use of peer-led education in patient safety. Findings. Four studies met the inclusion criteria: two were conducted in health care students and two in medical practitioners. Three studies used pre-post evaluation, with one containing a comparator group. One study a post-intervention evaluation only. All studies undertook Kirkpatrick Level 2 evaluations, showing significant improvements in attitudes and knowledge. One study undertook Level 3 and 4 evaluations, showing improvement in self-reported behaviors and engagement in quality improvement initiatives. Summary. There are few studies evaluating peer-led education in patient safety and formal and high-quality evaluations are lacking. PMID:29606704

Coherent x-ray zoom condenser lens for diffractive and scanning microscopy.

PubMed

Kimura, Takashi; Matsuyama, Satoshi; Yamauchi, Kazuto; Nishino, Yoshinori

2013-04-22

We propose a coherent x-ray zoom condenser lens composed of two-stage deformable Kirkpatrick-Baez mirrors. The lens delivers coherent x-rays with a controllable beam size, from one micrometer to a few tens of nanometers, at a fixed focal position. The lens is suitable for diffractive and scanning microscopy. We also propose non-scanning coherent diffraction microscopy for extended objects by using an apodized focused beam produced by the lens with a spatial filter. The proposed apodized-illumination method will be useful in highly efficient imaging with ultimate storage ring sources, and will also open the way to single-shot coherent diffraction microscopy of extended objects with x-ray free-electron lasers.

Computational and Experimental Investigations of the Molecular Scale Structure and Dynamics of Gologically Important Fluids and Mineral-Fluid Interfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bowers, Geoffrey

United States Department of Energy grant DE-FG02-10ER16128, “Computational and Spectroscopic Investigations of the Molecular Scale Structure and Dynamics of Geologically Important Fluids and Mineral-Fluid Interfaces” (Geoffrey M. Bowers, P.I.) focused on developing a molecular-scale understanding of processes that occur in fluids and at solid-fluid interfaces using the combination of spectroscopic, microscopic, and diffraction studies with molecular dynamics computer modeling. The work is intimately tied to the twin proposal at Michigan State University (DOE DE-FG02-08ER15929; same title: R. James Kirkpatrick, P.I. and A. Ozgur Yazaydin, co-P.I.).

Assessing the impact of egg sweating on Salmonella Enteritidis penetration into shell eggs.

PubMed

Gradl, Janet A; Curtis, Patricia A; Jones, Deana R; Anderson, Kenneth E

2017-07-01

Salmonella Enteritidis (SE) prevalence in eggs is a major concern to the egg industry. Some research has shown that egg sweating can increase Salmonella penetration into egg contents when refrigerated eggs are moved to a warmer temperature. This occurs when eggs are tempered before wash, to minimize thermal cracks. The effect of egg sweating on SE penetration into shell eggs over a 6 week storage period at 4°C was assessed. A 2 × 2 factorial of SE inoculation and egg sweating was utilized. Treatments included (SES) nalidixic acid (NA)-resistant SE inoculated and sweated, (SENS) NA-resistant SE inoculated and not sweated, (NSES) buffered peptone water (BPW) inoculated and sweated, and (NSENS) BPW inoculated and not sweated. Eggs were inoculated with 108 SE. Eggs formed condensation for approximately 17 min in a 32°C incubator. Shell rinse, shell emulsion, and egg contents were sampled then enumerated and assessed for prevalence of SE over a 6 wk storage period at 4°C. After wk 1, the SENS shell rinse had higher SE counts (0.32 log10 CFU/mL) than the other 3 treatments, where no SE was enumerated. A significant week by treatment interaction was found for the shell rinse SE detection (P < 0.05). In subsequent weeks, no SE counts were obtained from the egg shell rinse, shell emulsion, or egg contents. The SENS shell rinses had significantly higher SE prevalence than the SES rinses in weeks 1 (100% vs. 34.3%), 2 (57.6% vs. 22.2%), and 3 (38.2% vs. 11.1%) (P < 0.05). In samples from weeks 4, 5, and 6, there was no difference in SE prevalence between SES and SENS. Egg sweating did not increase SE penetration into the shell emulsion across treatment or week (P < 0.05). The decreasing trend of SE prevalence obtained over the study period indicate that refrigeration is effective at inhibiting SE growth. These results indicate that egg sweating occurring under common US egg handling practices is not harmful to egg safety. © 2017 Poultry Science Association Inc.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosch, R.; Boutin, J. Y.; Le Breton, J. P.

This article describes x-ray imaging with grazing-incidence microscopes, developed for the experimental program carried out on the Ligne d'Integration Laser (LIL) facility [J. P. Le Breton et al., Inertial Fusion Sciences and Applications 2001 (Elsevier, Paris, 2002), pp. 856-862] (24 kJ, UV--0.35 nm). The design includes a large target-to-microscope (400-700 mm) distance required by the x-ray ablation issues anticipated on the Laser MegaJoule facility [P. A. Holstein et al., Laser Part. Beams 17, 403 (1999)] (1.8 MJ) which is under construction. Two eight-image Kirkpatrick-Baez microscopes [P. Kirkpatrick and A. V. Baez J. Opt. Soc. Am. 38, 766 (1948)] with differentmore » spectral wavelength ranges and with a 400 mm source-to-mirror distance image the target on a custom-built framing camera (time resolution of {approx}80 ps). The soft x-ray version microscope is sensitive below 1 keV and its spatial resolution is better than 30 {mu}m over a 2-mm-diam region. The hard x-ray version microscope has a 10 {mu}m resolution over an 800-{mu}m-diam region and is sensitive in the 1-5 keV energy range. Two other x-ray microscopes based on an association of toroidal/spherical surfaces (T/S microscopes) produce an image on a streak camera with a spatial resolution better than 30 {mu}m over a 3 mm field of view in the direction of the camera slit. Both microscopes have been designed to have, respectively, a maximum sensitivity in the 0.1-1 and 1-5 keV energy range. We present the original design of these four microscopes and their test on a dc x-ray tube in the laboratory. The diagnostics were successfully used on LIL first experiments early in 2005. Results of soft x-ray imaging of a radiative jet during conical shaped laser interaction are shown.« less

Evaluation of the flipped classroom approach in a veterinary professional skills course.

PubMed

Moffett, Jenny; Mill, Aileen C

2014-01-01

The flipped classroom is an educational approach that has had much recent coverage in the literature. Relatively few studies, however, use objective assessment of student performance to measure the impact of the flipped classroom on learning. The purpose of this study was to evaluate the use of a flipped classroom approach within a medical education setting to the first two levels of Kirkpatrick and Kirkpatrick's effectiveness of training framework. This study examined the use of a flipped classroom approach within a professional skills course offered to postgraduate veterinary students. A questionnaire was administered to two cohorts of students: those who had completed a traditional, lecture-based version of the course (Introduction to Veterinary Medicine [IVM]) and those who had completed a flipped classroom version (Veterinary Professional Foundations I [VPF I]). The academic performance of students within both cohorts was assessed using a set of multiple-choice items (n=24) nested within a written examination. Data obtained from the questionnaire were analyzed using Cronbach's alpha, Kruskal-Wallis tests, and factor analysis. Data obtained from student performance in the written examination were analyzed using the nonparametric Wilcoxon rank sum test. A total of 133 IVM students and 64 VPF I students (n=197) agreed to take part in the study. Overall, study participants favored the flipped classroom approach over the traditional classroom approach. With respect to student academic performance, the traditional classroom students outperformed the flipped classroom students on a series of multiple-choice items (IVM mean =21.4±1.48 standard deviation; VPF I mean =20.25±2.20 standard deviation; Wilcoxon test, w=7,578; P<0.001). This study demonstrates that learners seem to prefer a flipped classroom approach. The flipped classroom was rated more positively than the traditional classroom on many different characteristics. This preference, however, did not translate into improved student performance, as assessed by a series of multiple-choice items delivered during a written examination.

The role of simulation in continuing medical education for acute care physicians: a systematic review.

PubMed

Khanduja, P Kristina; Bould, M Dylan; Naik, Viren N; Hladkowicz, Emily; Boet, Sylvain

2015-01-01

We systematically reviewed the effectiveness of simulation-based education, targeting independently practicing qualified physicians in acute care specialties. We also describe how simulation is used for performance assessment in this population. Data source included: DataMEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane CENTRAL Database of Controlled Trials, and National Health Service Economic Evaluation Database. The last date of search was January 31, 2013. All original research describing simulation-based education for independently practicing physicians in anesthesiology, critical care, and emergency medicine was reviewed. Data analysis was performed in duplicate with further review by a third author in cases of disagreement until consensus was reached. Data extraction was focused on effectiveness according to Kirkpatrick's model. For simulation-based performance assessment, tool characteristics and sources of validity evidence were also collated. Of 39 studies identified, 30 studies focused on the effectiveness of simulation-based education and nine studies evaluated the validity of simulation-based assessment. Thirteen studies (30%) targeted the lower levels of Kirkpatrick's hierarchy with reliance on self-reporting. Simulation was unanimously described as a positive learning experience with perceived impact on clinical practice. Of the 17 remaining studies, 10 used a single group or "no intervention comparison group" design. The majority (n = 17; 44%) were able to demonstrate both immediate and sustained improvements in educational outcomes. Nine studies reported the psychometric properties of simulation-based performance assessment as their sole objective. These predominantly recruited independent practitioners as a convenience sample to establish whether the tool could discriminate between experienced and inexperienced operators and concentrated on a single aspect of validity evidence. Simulation is perceived as a positive learning experience with limited evidence to support improved learning. Future research should focus on the optimal modality and frequency of exposure, quality of assessment tools and on the impact of simulation-based education beyond the individuals toward improved patient care.

Educational Interventions to Improve Handover in Health Care: An Updated Systematic Review.

PubMed

Gordon, Morris; Hill, Elaine; Stojan, Jennifer N; Daniel, Michelle

2018-04-03

Effective handovers (handoffs) are vital to patient safety. Medical educators investigated educational interventions to improve handovers in a 2011 systematic review. The number of publications on handover education has increased since then, so authors undertook this updated review. The authors considered studies involving educational interventions to improve handover amongst undergraduate or postgraduate health professionals in acute care settings. In September 2016, two authors independently conducted a standardized search of online databases and completed a data extraction and quality assessment of the articles included. They conducted a content analysis of and extracted key themes from the interventions described. Eighteen reports met the inclusion criteria. All but two were based in the United States. Interventions most commonly involved single-patient exercises based on simulation and role play. Many studies mentioned multiprofessional education or practice, but interventions occurred largely in single-professional contexts. Analysis of interventions revealed three major themes: facilitating information management, reducing the potential for errors, and improving confidence. The majority of studies assessed Kirkpatrick's outcomes of knowledge and skill improvement (Levels 1 and 2). The strength of conclusions was generally weak. Despite increased interest in and publications on handover, the quality of published research remains poor. Inadequate reporting of interventions, especially as they relate to educational theory, pedagogy, curricula, and resource requirements, continues to impede replication. Weaknesses in methodologies, length of follow-up, and scope of outcomes evaluation (Kirkpatrick levels) persist. Future work to address these issues, and to consider the role of multiprofessional and multiple-patient handovers, is vital.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Conceptualising the lack of health insurance coverage.

PubMed

Davis, J B

2000-01-01

This paper examines the lack of health insurance coverage in the US as a public policy issue. It first compares the problem of health insurance coverage to the problem of unemployment to show that in terms of the numbers of individuals affected lack of health insurance is a problem comparable in importance to the problem of unemployment. Secondly, the paper discusses the methodology involved in measuring health insurance coverage, and argues that the current method of estimation of the uninsured underestimates the extent that individuals go without health insurance. Third, the paper briefly introduces Amartya Sen's functioning and capabilities framework to suggest a way of representing the extent to which individuals are uninsured. Fourth, the paper sketches a means of operationalizing the Sen representation of the uninsured in terms of the disability-adjusted life year (DALY) measure.

Hidden symmetries for ellipsoid-solitonic deformations of Kerr-Sen black holes and quantum anomalies

NASA Astrophysics Data System (ADS)

Vacaru, Sergiu I.

2013-02-01

We prove the existence of hidden symmetries in the general relativity theory defined by exact solutions with generic off-diagonal metrics, nonholonomic (non-integrable) constraints, and deformations of the frame and linear connection structure. A special role in characterization of such spacetimes is played by the corresponding nonholonomic generalizations of Stackel-Killing and Killing-Yano tensors. There are constructed new classes of black hole solutions and we study hidden symmetries for ellipsoidal and/or solitonic deformations of "prime" Kerr-Sen black holes into "target" off-diagonal metrics. In general, the classical conserved quantities (integrable and not-integrable) do not transfer to the quantized systems and produce quantum gravitational anomalies. We prove that such anomalies can be eliminated via corresponding nonholonomic deformations of fundamental geometric objects (connections and corresponding Riemannian and Ricci tensors) and by frame transforms.

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office (SSCO). Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. Here, she receives an overview of a robotic console station used to practice satellite servicing activities. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Chris Gunn Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office (SSCO). In this image, she is joined by Chris Scolese, Goddard Center Director (right) and Frank Cepollina, Associate Director of the SSCO (left). Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Chris Gunn Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Senator Barbara Mikulski Visits NASA Goddard

NASA Image and Video Library

2016-01-06

Sen. Barbara Mikulski participated in a ribbon cutting at NASA’s Goddard Space Flight Center on January 6th, 2016, to officially open the new Robotic Operations Center (ROC) developed by the Satellite Servicing Capabilities Office (SSCO). In this image, she is joined by Chris Scolese, Goddard Center Director (right) and Frank Cepollina, Associate Director of the SSCO (left). Within the ROC's black walls, NASA is testing technologies and operational procedures for science and exploration missions, including the Restore-L satellite servicing mission and also the Asteroid Redirect Mission. During her tour of the ROC, Sen. Mikulski saw first-hand an early version of the NASA Servicing Arm, a 2-meter-class robot with the dexterity to grasp and refuel a satellite on orbit. She also heard a description of Raven, a payload launching to the International Space Station that will demonstrate real-time, relative space navigation technology. The robotic technologies that NASA is developing within the ROC also support the Journey to Mars. Learn more about NASA’s satellite servicing technologies at ssco.gsfc.nasa.gov/. Image credit: NASA/Chris Gunn Read more: www.nasa.gov/feature/goddard/2016/maryland-sen-barbara-mi... NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Influence of a highly purified senna extract on colonic epithelium.

PubMed

van Gorkom, B A; Karrenbeld, A; van Der Sluis, T; Koudstaal, J; de Vries, E G; Kleibeuker, J H

2000-01-01

Chronic use of sennoside laxatives often causes pseudomelanosis coli. A recent study suggested that pseudomelanosis coli is associated with an increased colorectal cancer risk. A single high dose of highly purified senna extract increased proliferation rate and reduced crypt length in the sigmoid colon compared to historical controls. To evaluate in a controlled study the effects of highly purified senna extract on cell proliferation and crypt length in the entire colon and on p53 and bcl-2 expression. Addition of a senna extract to colonic lavage was studied in 184 consecutive outpatients. From 32 randomised patients, 15 with sennosides (Sen), 17 without (NSen), biopsies were taken. Proliferative activity was studied in 4 areas of the colon, using 5-bromo-2'-deoxyuridine labelling and immunohistochemistry (labelling index, LI). Expression of p53 and bcl-2 in the sigmoid colon was determined immunohistochemically. Crypts were shorter in Sen than in NSen in the transverse and sigmoid colon. LI was higher in Sen than in NSen in the entire colon. No difference in p53 expression was seen. Bcl-2 expression was higher in both groups when crypts were shorter and/or proliferation was increased. Sennosides induce acute massive cell loss probably by apoptosis, causing shorter crypts, and increased cell proliferation and inhibition of apoptosis to restore cellularity. These effects may reflect the mechanism for the suggested cancer-promoting effect of chronic sennoside use. Copyright 2000 S. Karger AG, Basel

Disrupted dispersal and its genetic consequences: Comparing protected and threatened baboon populations (Papio papio) in West Africa.

PubMed

Ferreira da Silva, Maria Joana; Kopp, Gisela H; Casanova, Catarina; Godinho, Raquel; Minhós, Tânia; Sá, Rui; Zinner, Dietmar; Bruford, Michael W

2018-01-01

Dispersal is a demographic process that can potentially counterbalance the negative impacts of anthropogenic habitat fragmentation. However, mechanisms of dispersal may become modified in populations living in human-dominated habitats. Here, we investigated dispersal in Guinea baboons (Papio papio) in areas with contrasting levels of anthropogenic fragmentation, as a case study. Using molecular data, we compared the direction and extent of sex-biased gene flow in two baboon populations: from Guinea-Bissau (GB, fragmented distribution, human-dominated habitat) and Senegal (SEN, continuous distribution, protected area). Individual-based Bayesian clustering, spatial autocorrelation, assignment tests and migrant identification suggested female-mediated gene flow at a large spatial scale for GB with evidence of contact between genetically differentiated males at one locality, which could be interpreted as male-mediated gene flow in southern GB. Gene flow was also found to be female-biased in SEN for a smaller scale. However, in the southwest coastal part of GB, at the same geographic scale as SEN, no sex-biased dispersal was detected and a modest or recent restriction in GB female dispersal seems to have occurred. This population-specific variation in dispersal is attributed to behavioural responses to human activity in GB. Our study highlights the importance of considering the genetic consequences of disrupted dispersal patterns as an additional impact of anthropogenic habitat fragmentation and is potentially relevant to the conservation of many species inhabiting human-dominated environments.

ENSO impact on hydrology in Peru

NASA Astrophysics Data System (ADS)

Lavado-Casimiro, W. S.; Felipe, O.; Silvestre, E.; Bourrel, L.

2013-04-01

The El Niño and La Niña impacts on the hydrology of Peru were assessed based on discharge data (1968-2006) of 20 river catchments distributed over three drainage regions in Peru: 14 in the Pacific Coast (PC), 3 in the Lake Titicaca (TL) region, and 3 in the Amazonas (AM). To classify the El Niño and La Niña events, we used the Southern Oscillation Index (SOI) based on hydrological years (September to August). Using the SOI values, the events were re-classified as strong El Niño (SEN), moderate El Niño (MEN), normal years (N), moderate La Niña (MLN) and strong La Niña (SLN). On average during the SEN years, sharp increases occurred in the discharges in the north central area of the PC and decreases in the remaining discharge stations that were analyzed, while in the years of MEN events, these changes show different responses than those of the SEN. During the years classified as La Niña, positive changes are mostly observed in the majority of the stations in the rivers located in the center of Peru's Pacific Coast. Another important result of this work is that the Ilave River (south of the Titicaca watershed) shows higher positive (negative) impacts during La Niña (El Niño) years, a fact that is not clearly seen in the rivers of the northern part of the Titicaca watershed (Ramis and Huancane rivers).

T56. AN EXPLORATORY ANALYSIS CONVERTING SCORES BETWEEN THE PANSS AND BNSS

PubMed Central

Kott, Alan; Daniel, David

2018-01-01

Abstract Background The Brief Negative Symptom Scale is a relatively new instrument designed specifically to measure the negative symptoms in schizophrenia. Recently more clinical trials include the BNSS scale as a secondary or exploratory outcome, typically along with the PANSS. In the current analysis we aimed at establishing the equations that would allow conversion between the BNSS scale total score and the PANSS negative subscale and PANSS negative factors score as well as conversion equations between the expressive deficits and avolition/apathy factors of the scales. (Kirkpatrick, 2011; Strauss, 2012) Methods Data from 518 schizophrenia clinical trials subjects with both PANSS and BNSS data available were used. Regression analyses predicting the BNSS total score with the PANSS negative subscale score, and the BNSS total score with the PANSS Negative factor (NFS) score were performed on data from all subjects. Regression analyses predicting the BNSS avolition/apathy factor (items 1, 2, 3, 5, 6, 7, and 8) with the PANSS avolition/apathy factor (items N2, N4 and G16) and the BNSS expressive deficits factor (items 4, 9, 10, 11, 12, and 13)with the expressive deficits factor (items N1, N3, N6, G5, G7, and G13)of the PANSS were performed on a sample of 318 subjects with individual BNSS item scores available. In addition to estimating the equations we as well calculated the Pearson’s correlations between the scales. Results The PANSS and BNSS avolition/apathy factors were highly correlated (r=0.70) as were the expressive deficit factors r=0.83). The following equations predicting the BNSS total score were obtained from regression analyses performed on 2,560 data points: BNSS_total = -11.64 + 2.10*PANSS_negative_subscale BNSS_total = -9.26 + 2.11*PANSS_NFS The following equations predicting the BNSS factor scores from the PANSS factor scores were obtained from regression analyses performed on 1,634 data points: BNSS_avolition/apathy = -2.40 + 2.38 * PANSS_avolition/apathy BNSS_expressive_deficit_factor = -4.21 + 1.27 * PANSS_expressive_deficit_factor Discussion The BNSS differs from the PANSS negative factor because it addresses all five currently recognized domains of negative symptoms including anhedonia and attempts to differentiate anticipatory from consummatory states. In our analysis we have replicated the strong correlation between the BNSS total score and PANSS negative subscale and newly identified strong correlations between the BNSS total score and NFS as well as strong correlations between the avolotion/apathy and expressive deficit factors of the BNSS and the PANSS scales. (Kirkpatrick, 2011)The provided equations offer a useful tool allowing researchers and clinicians to easily convert the data between the instruments for reasons such as pooling data from multiple trials using one of the instruments, to allow interpretation of results within the context of previously conducted research, etc. but as well offer a framework for risk based monitoring to identify data deviating from the expected relationship and allow for a targeted exploration of the causes for such a disagreement. The data used for analysis included not only subjects with predominantly negative symptoms but as well acutely psychotic subjects as well as subjects in stable conditions allowing therefore to generalize the results across the majority of schizophrenic subjects. This post-hoc analysis is exploratory. We plan to further explore the potential utility of equations addressing the relationships among schizophrenia measures of symptom severity in an iterative manner with larger datasets.

Quantum critical scaling in the disordered itinerant ferromagnet UCo 1-xFe xGe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Kevin; Eley, Serena Merteen; Civale, Leonardo

The Belitz-Kirkpatrick-Vojta (BKV) theory shows in excellent agreement with experiment that ferromagnetic quantum phase transitions (QPTs) in clean metals are generally first order due to the coupling of the magnetization to electronic soft modes, in contrast to the classical analogue that is an archetypical second-order phase transition. For disordered metals the BKV theory predicts that the secondorder nature of the QPT is restored because the electronic soft modes change their nature from ballistic to diffusive. Lastly, our low-temperature magnetization study identifies the ferromagnetic QPT in the disordered metal UCo 1$-$xFe xGe as the first clear example that exhibits the associatedmore » critical exponents predicted by the BKV theory.« less

Above and beyond short-term mating, long-term mating is uniquely tied to human personality.

PubMed

Holtzman, Nicholas S; Strube, Michael J

2013-12-16

To what extent are personality traits and sexual strategies linked? The literature does not provide a clear answer, as it is based on the Sociosexuality model, a one-dimensional model that fails to measure long-term mating (LTM). An improved two-dimensional model separately assesses long-term and short-term mating (STM; Jackson and Kirkpatrick, 2007). In this paper, we link this two-dimensional model to an array of personality traits (Big 5, Dark Triad, and Schizoid Personality). We collected data from different sources (targets and peers; Study 1), and from different nations (United States, Study 1; India, Study 2). We demonstrate for the first time that, above and beyond STM, LTM captures variation in personality.

Quantum critical scaling in the disordered itinerant ferromagnet UCo 1-xFe xGe

DOE PAGES

Huang, Kevin; Eley, Serena Merteen; Civale, Leonardo; ...

2016-11-30

The Belitz-Kirkpatrick-Vojta (BKV) theory shows in excellent agreement with experiment that ferromagnetic quantum phase transitions (QPTs) in clean metals are generally first order due to the coupling of the magnetization to electronic soft modes, in contrast to the classical analogue that is an archetypical second-order phase transition. For disordered metals the BKV theory predicts that the secondorder nature of the QPT is restored because the electronic soft modes change their nature from ballistic to diffusive. Lastly, our low-temperature magnetization study identifies the ferromagnetic QPT in the disordered metal UCo 1$-$xFe xGe as the first clear example that exhibits the associatedmore » critical exponents predicted by the BKV theory.« less

[Evaluating a blended-learning program on developing teamwork competence].

PubMed

Aguado, David; Arranz, Virginia; Valera-Rubio, Ana; Marín-Torres, Susana

2011-08-01

The knowledge, skills and abilities that are required to work optimally in teams are critical for many types of work. Organizations can provide access to these skills by means of training programs. Diverse studies show how traditional in-site training methodologies can improve teamwork knowledge, skills and abilities. Nevertheless, in-site methods can be complemented with on-line strategies that result in blended-learning programs. The aim of this work is to analyze, following Kirkpatrick's assessment levels, the effectiveness of a blended-learning program of teamwork training in an organizational context. Carried out with 102 professionals, the results show participants' satisfaction with the program, high level of learning (of both declarative and procedural knowledge), and a moderate level of transfer of learning to the job.

Understanding Soil Moisture

USDA-ARS?s Scientific Manuscript database

Understanding soil moisture is critical for landscape irrigation management. This landscaep irrigation seminar will compare volumetric and matric potential soil-moisture sensors, discuss the relationship between their readings and demonstrate how to use these data. Soil water sensors attempt to sens...

Low cost structural health monitoring of bridges using wireless SenSpot sensors.

DOT National Transportation Integrated Search

2012-05-01

Deterioration of highway bridges is a common, yet complex problem. To protect highway bridges, this : project combines a number of recent and emerging technologies microstructured sensing, ultra-lowpower : wireless communication, and advanced mic...

Climate variability, vulnerability, and coping mechanism in Alaknanda catchment, Central Himalaya, India.

PubMed

Kumar, Kireet; Joshi, Sneh; Joshi, Varun

2008-06-01

A study was carried out to discover trends in the rainfall and temperature pattern of the Alaknanda catchment in the Central Himalaya. Data on the annual rainfall, monsoon rainfall for the last decade, and average annual temperatures over the last few decades were analyzed. Nonparametric methods (Mann-Kendall and Sen's method) were employed to identify trends. The Mann-Kendall test shows a decline in rainfall and rise in temperature, and these trends were found to be statistically significant at the 95% confidence level for both transects. Sen's method also confirms this trend. This aspect has to be considered seriously for the simple reason that if the same trend continues in the future, more chances of drought are expected. The impact of climate change has been well perceived by the people of the catchment, and a coping mechanism has been developed at the local level.

ICT in the Education of Students with SEN: Perceptions of Stakeholders

NASA Astrophysics Data System (ADS)

Ribeiro, Jaime; Moreira, António; Almeida, Ana Margarida

Portugal is experiencing a technological reform in education. Technological refurbishing of schools and training of students and teachers is a reality on the rise, enhanced by the implementation of the Education Technological Plan, which also aims at computer skills certification, by 2010, of 90% of teachers. In a School that must be adjusted to all pupils, Special Educational Needs cannot be neglected and the nature and constitution of its computer resources should obviate the support of these students. ICT training is essential to benefit all students from its use. In the case of SEN, this need for training is of paramount importance to establish itself as a facilitator for these students. ICT Coordinators are the visible face of ICT implementation in schools; their functions include the management of the schools computer facilities and to zeal for the ICT training of fellow teachers.

Observing the contour profile of a Kerr-Sen black hole

NASA Astrophysics Data System (ADS)

Lan, X. G.; Pu, J.

2018-06-01

In this paper, the shadow and the corresponding naked singularity cast by a Kerr-Sen black hole are studied. It is found that the shadow of a rotating black hole would be a dark zone surrounded by a deformed circle, and the shadow is distorted more away from a circle when the black hole approaches the extremal case. Besides, it is shown that the mean radius of the shadow decreases and distortion parameter increases with the increasing of charge, respectively. However, the mean radius and the distortion parameter vary complicatedly with the change of spin parameter. In the beginning, both observables decrease rapidly with the increasing of specific angular momentum, nevertheless, they increase slightly in the latter part. These results show that there would be a significant effect of the spin on the shadows, which would be of great importance for probing the nature of the black hole.

Organic Synthetic Advanced Materials for Optoelectronic and Energy Applications (at National Sun Yat-sen University) 

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yen, Hung-Ju

These slides cover Hung-Ju Yen's recent work in the synthesis and structural design of functional materials, which were further used for optoelectronic and energy applications, such as lithium ion battery, solar cell, LED, electrochromic, and fuel cells. This was for a job interview at National Sun Yat-sen University. The following topics are detailed: current challenges for lithium-ion batteries; graphene, graphene oxide and nanographene; nanographenes with various functional groups; fine tune d-spacing through organic synthesis: varying functional group; schematic view of LIBs; nanographenes as LIB anode; rate performance (charging-discharging); electrochromic technology; electrochromic materials; advantages of triphenylamine; requirement of electrochromic materials formore » practical applications; low driving voltage and long cycle life; increasing the electroactive sites by multi-step synthetic procedures; synthetic route to starburst triarylamine-based polyamide; electrochromism ranging from visible to NIR region; transmissive to black electrochromism; RGB and CMY electrochromism.« less

[Historical origins between National Medical Association of China and Boji Hospital in Guangzhou].

PubMed

Liu, Pinming

2015-09-01

In 2015, National Medical Association of China, now being called the Chinese Medical Association, celebrates its centennial and Boji Hospital in Guangzhou ( also known as Canton Hospital, or the Canton Pok Tsai Hospital, and now Sun Yat-sen Memorial Hospital of Sun Yat-sen University ) marks its 180th anniversary. Three major historical events establish the role of Boji Hospital in the founding and development of the National Medical Association of China during the last 100 years, viz.: ①hosting and participating in the establishment of the Medical Missionary Association of China and its official journal: the China Medical Missionary Journal; ②holding the 11th scientific sessions of the National Medical Association of China; ③nominating Dr. Wu Lien-teh as a candidate for the Nobel Prize in Physiology or Medicine in 1935 by William Warder Cadbury, the president of Boji Hospital.

Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database.

PubMed

Hoffmann, Sebastian; Kleinstreuer, Nicole; Alépée, Nathalie; Allen, David; Api, Anne Marie; Ashikaga, Takao; Clouet, Elodie; Cluzel, Magalie; Desprez, Bertrand; Gellatly, Nichola; Goebel, Carsten; Kern, Petra S; Klaric, Martina; Kühnl, Jochen; Lalko, Jon F; Martinozzi-Teissier, Silvia; Mewes, Karsten; Miyazawa, Masaaki; Parakhia, Rahul; van Vliet, Erwin; Zang, Qingda; Petersohn, Dirk

2018-05-01

Cosmetics Europe, the European Trade Association for the cosmetics and personal care industry, is conducting a multi-phase program to develop regulatory accepted, animal-free testing strategies enabling the cosmetics industry to conduct safety assessments. Based on a systematic evaluation of test methods for skin sensitization, five non-animal test methods (DPRA (Direct Peptide Reactivity Assay), KeratinoSens TM , h-CLAT (human cell line activation test), U-SENS TM , SENS-IS) were selected for inclusion in a comprehensive database of 128 substances. Existing data were compiled and completed with newly generated data, the latter amounting to one-third of all data. The database was complemented with human and local lymph node assay (LLNA) reference data, physicochemical properties and use categories, and thoroughly curated. Focused on the availability of human data, the substance selection resulted nevertheless resulted in a high diversity of chemistries in terms of physico-chemical property ranges and use categories. Predictivities of skin sensitization potential and potency, where applicable, were calculated for the LLNA as compared to human data and for the individual test methods compared to both human and LLNA reference data. In addition, various aspects of applicability of the test methods were analyzed. Due to its high level of curation, comprehensiveness, and completeness, we propose our database as a point of reference for the evaluation and development of testing strategies, as done for example in the associated work of Kleinstreuer et al. We encourage the community to use it to meet the challenge of conducting skin sensitization safety assessment without generating new animal data.

Wg Signaling via Zw3 and Mad Restricts Self-Renewal of Sensory Organ Precursor Cells in Drosophila

PubMed Central

Quijano, Janine C.; Stinchfield, Michael J.; Newfeld, Stuart J.

2011-01-01

It is well known that the Dpp signal transducer Mad is activated by phosphorylation at its carboxy-terminus. The role of phosphorylation on other regions of Mad is not as well understood. Here we report that the phosphorylation of Mad in the linker region by the Wg antagonist Zw3 (homolog of vertebrate Gsk3-β) regulates the development of sensory organs in the anterior–dorsal quadrant of the wing. Proneural expression of Mad-RNA interference (RNAi) or a Mad transgene with its Zw3/Gsk3-β phosphorylation sites mutated (MGM) generated wings with ectopic sensilla and chemosensory bristle duplications. Studies with pMad-Gsk (an antibody specific to Zw3/Gsk3-β-phosphorylated Mad) in larval wing disks revealed that this phosphorylation event is Wg dependent (via an unconventional mechanism), is restricted to anterior–dorsal sensory organ precursors (SOP) expressing Senseless (Sens), and is always co-expressed with the mitotic marker phospho-histone3. Quantitative analysis in both Mad-RNAi and MGM larval wing disks revealed a significant increase in the number of Sens SOP. We conclude that the phosphorylation of Mad by Zw3 functions to prevent the self-renewal of Sens SOP, perhaps facilitating their differentiation via asymmetric division. The conservation of Zw3/Gsk3-β phosphorylation sites in vertebrate homologs of Mad (Smads) suggests that this pathway, the first transforming growth factor β-independent role for any Smad protein, may be widely utilized for regulating mitosis during development. PMID:21868604

Learning disabilities among extremely preterm children without neurosensory impairment: Comorbidity, neuropsychological profiles and scholastic outcomes.

PubMed

Johnson, Samantha; Strauss, Victoria; Gilmore, Camilla; Jaekel, Julia; Marlow, Neil; Wolke, Dieter

2016-12-01

Children born extremely preterm are at high risk for intellectual disability, learning disabilities, executive dysfunction and special educational needs, but little is understood about the comorbidity of intellectual and learning disabilities in this population. This study explored comorbidity in intellectual disability (ID) and learning disabilities (LD) in children born extremely preterm (EP; <26 +0 weeks' gestation). A UK national cohort of 161 EP children and 153 term-born controls without neurosensory impairments was assessed at 11years of age (the EPICure Study). IQ, mathematics and reading attainment, executive function, visuospatial processing and sensorimotor skills were assessed using standardised tests, and curriculum-based attainment and special educational needs (SEN) using teacher reports. Overall, 75 (47%) EP children and 7 (4.6%) controls had ID or LD (RR 10.12; 95% CI 4.81, 21.27). Comorbidity in ID/LD was more common among EP children than controls (24% vs. 0%). EP children with comorbid ID/LD had significantly poorer neuropsychological abilities and curriculum-based attainment than EP children with an isolated disability or no disabilities. LD were associated with a 3 times increased risk for SEN. However, EP children with ID alone had poorer neuropsychological abilities and curriculum-based attainment than children with no disabilities, yet there was no increase in SEN provision among this group. EP children are at high risk for comorbid intellectual and learning disabilities. Education professionals should be aware of the complex nature of EP children's difficulties and the need for multi-domain assessments to guide intervention. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Identification of a novel gene in ROD9 island of Salmonella Enteritidis involved in the alteration of virulence-associated genes expression.

PubMed

Das, Susmita; Ray, Shilpa; Ryan, Daniel; Sahu, Bikash; Suar, Mrutyunjay

2018-01-01

Salmonella enterica subsp. I serovar Enteritidis (S. Enteritidis), one of the causative agents for non-typhoidal gastrointestinal diseases in humans is an intracellular bacterium and mechanism for its invasion into host cells is critical to cause infection. The virulence of the pathogen is explained by the expression of genes located on its pathogenicity islands, mostly encoded under SPI-1 and SPI-2. However, S. Typhimurium SL1344, despite sharing ∼98% of its genome with S. Enteritidis P125109, lacks few regions of differences (ROD) that are hypothesized to impart virulence potential to S. Enteritidis. In this study, we created different mutants in the ROD9 island of S. Enteritidis, also referred as SPI-19 and identified a novel locus, SEN1005, encoding a hypothetical protein that is involved in its pathogenesis. ΔSEN1005 displayed significantly reduced entry into cultured epithelial cells as well as uptake by macrophages and failed to cause acute colitis in C57BL/6 mice at day 3 post-infection (p.i.). Additionally, the global transcriptome analysis revealed a highly repressed SPI-1 and other down-regulated genes responsible for flagellar assembly, chemotaxis and motility in the mutant which correlated with decreased invasion and abated inflammation as compared to the wild-type. Therefore, our findings revealed that ΔSEN1005 was attenuated in vitro as well as in vivo and we propose this hypothetical protein to play a role in altering the expression of genes involved in Salmonella virulence.

CREW TRAINING (GARN) - STS-51E

NASA Image and Video Library

1985-01-14

Senator Jake Garn (R., Utah), center on front row, listens to a briefing with Jeff Bingham, the Senator's aide. Garn and Binham on front row of conference table 1. TRAINING - GARN, E. J. "JAKE", SEN. Also available in 35 CN

Field Evaluation of Dried Blood Spots for Routine HIV-1 Viral Load and Drug Resistance Monitoring in Patients Receiving Antiretroviral Therapy in Africa and Asia

PubMed Central

Monleau, Marjorie; Eymard-Duvernay, Sabrina; Dagnra, Anoumou; Kania, Dramane; Ngo-Giang-Huong, Nicole; Touré-Kane, Coumba; Truong, Lien X. T.; Chaix, Marie-Laure; Delaporte, Eric; Ayouba, Ahidjo; Peeters, Martine

2014-01-01

Dried blood spots (DBS) can be used in developing countries to alleviate the logistic constraints of using blood plasma specimens for viral load (VL) and HIV drug resistance (HIVDR) testing, but they should be assessed under field conditions. Between 2009 and 2011, we collected paired plasma-DBS samples from treatment-experienced HIV-1-infected adults in Burkina Faso, Cameroon, Senegal, Togo, Thailand, and Vietnam. The DBS were stored at an ambient temperature for 2 to 4 weeks and subsequently at −20°C before testing. VL testing was performed on the plasma samples and DBS using locally available methods: the Abbott m2000rt HIV-1 test, generic G2 real-time PCR, or the NucliSENS EasyQ version 1.2 test. In the case of virological failure (VF), i.e., a plasma VL of ≥1,000 copies/ml, HIVDR genotyping was performed on paired plasma-DBS samples. Overall, we compared 382 plasma-DBS sample pairs for DBS VL testing accuracy. The sensitivities of the different assays in different laboratories for detecting VF using DBS varied from 75% to 100% for the m2000rt test in labs B, C, and D, 91% to 93% for generic G2 real-time PCR in labs A and F, and 85% for the NucliSENS test in lab E. The specificities varied from 82% to 97% for the m2000rt and NucliSENS tests and reached only 60% for the generic G2 test. The NucliSENS test showed good agreement between plasma and DBS VL but underestimated the DBS VL. The lowest agreement was observed for the generic G2 test. Genotyping was successful for 96/124 (77%) DBS tested, and 75/96 (78%) plasma-DBS pairs had identical HIVDR mutations. Significant discrepancies in resistance interpretations were observed in 9 cases, 6 of which were from the same laboratory. DBS can be successfully used as an alternative to blood plasma samples for routine VL and HIVDR monitoring in African and Asian settings. However, the selection of an adequate VL measurement method and the definition of the VF threshold should be considered, and laboratory performance should be monitored. PMID:24478491

Educational psychology and the effectiveness of inclusive education/mainstreaming.

PubMed

Lindsay, Geoff

2007-03-01

Inclusive education/mainstreaming is a key policy objective for the education of children and young people with special educational needs (SEN) and disabilities. This paper reviews the literature on the effectiveness of inclusive education/mainstreaming. The focus is on evidence for effects in terms of child outcomes with examination also of evidence on processes that support effectiveness. The review covers a range of SEN and children from pre-school to the end of compulsory education. Following an historical review of evidence on inclusive education/mainstreaming, the core of the paper is a detailed examination of all the papers published in eight journals from the field of special education published 2001-2005 (N=1373): Journal of Special Education, Exceptional Children, Learning Disabilities Research and Practice, Journal of Learning Disabilities, Remedial and Special Education, British Journal of Special Education, European Journal of Special Needs Education, and the International Journal of Inclusive Education. The derived categories were: comparative studies of outcomes: other outcome studies; non-comparative qualitative studies including non-experimental case studies; teacher practice and development; teacher attitudes; and the use of teaching assistants. Only 14 papers (1.0%) were identified as comparative outcome studies of children with some form of SEN. Measures used varied but included social as well as educational outcomes. Other papers included qualitative studies of inclusive practice, some of which used a non-comparative case study design while others were based on respondent's judgements, or explored process factors including teacher attitudes and the use of teaching assistants. Inclusive education/mainstreaming has been promoted on two bases: the rights of children to be included in mainstream education and the proposition that inclusive education is more effective. This review focuses on the latter issue. The evidence from this review does not provide a clear endorsement for the positive effects of inclusion. There is a lack of evidence from appropriate studies and, where evidence does exist, the balance was only marginally positive. It is argued that the policy has been driven by a concern for children's rights. The important task now is to research more thoroughly the mediators and moderators that support the optimal education for children with SEN and disabilities and, as a consequence, develop an evidence-based approach to these children's education.

Convolutional Neural Network for Multi-Source Deep Learning Crop Classification in Ukraine

NASA Astrophysics Data System (ADS)

Lavreniuk, M. S.

2016-12-01

Land cover and crop type maps are one of the most essential inputs when dealing with environmental and agriculture monitoring tasks [1]. During long time neural network (NN) approach was one of the most efficient and popular approach for most applications, including crop classification using remote sensing data, with high an overall accuracy (OA) [2]. In the last years the most popular and efficient method for multi-sensor and multi-temporal land cover classification is convolution neural networks (CNNs). Taking into account presence clouds in optical data, self-organizing Kohonen maps (SOMs) are used to restore missing pixel values in a time series of optical imagery from Landsat-8 satellite. After missing data restoration, optical data from Landsat-8 was merged with Sentinel-1A radar data for better crop types discrimination [3]. An ensemble of CNNs is proposed for multi-temporal satellite images supervised classification. Each CNN in the corresponding ensemble is a 1-d CNN with 4 layers implemented using the Google's library TensorFlow. The efficiency of the proposed approach was tested on a time-series of Landsat-8 and Sentinel-1A images over the JECAM test site (Kyiv region) in Ukraine in 2015. Overall classification accuracy for ensemble of CNNs was 93.5% that outperformed an ensemble of multi-layer perceptrons (MLPs) by +0.8% and allowed us to better discriminate summer crops, in particular maize and soybeans. For 2016 we would like to validate this method using Sentinel-1 and Sentinel-2 data for Ukraine territory within ESA project on country level demonstration Sen2Agri. 1. A. Kolotii et al., "Comparison of biophysical and satellite predictors for wheat yield forecasting in Ukraine," The Int. Arch. of Photogram., Rem. Sens. and Spatial Inform. Scie., vol. 40, no. 7, pp. 39-44, 2015. 2. F. Waldner et al., "Towards a set of agrosystem-specific cropland mapping methods to address the global cropland diversity," Int. Journal of Rem. Sens. vol. 37, no. 14, pp 3196-3231, 2016. 3. S. Skakun et al., "Efficiency assessment of multitemporal C-band Radarsat-2 intensity and Landsat-8 surface reflectance satellite imagery for crop classification in Ukraine," IEEE Journal of Selected Topics in Applied Earth Observ. and Rem. Sens., 2015, DOI: 10.1109/JSTARS.2015.2454297.

Antibacterial resistances in uncomplicated urinary tract infections in women: ECO·SENS II data from primary health care in Austria

PubMed Central

2012-01-01

Background Uncomplicated urinary tract infections (UTI) are a frequent reason for consultation of women in primary health care. To avoid therapy failure and development of resistances, the choice of an antibiotic should be based on the knowledge of recent local resistance data but these data are scarce for the Austrian primary health care sector. Within the context of the ECO·SENS II study it was the aim to obtain appropriate and relevant local resistance data and describe the changes in the resistance pattern in comparison to the ECO·SENS study. Methods 23 GPs from different parts of Austria participated in the study between July 2007 and November 2008. According to the defined inclusion- and exclusion criteria female patients with symptoms of an uncomplicated UTI were included and a midstream urine sample was collected. In case of significant bacteriuria susceptibility testing of E. coli against 14 antibiotics was performed. Descriptive statistical methods were used. Results In 313 patients included in the study, a total of 147 E. coli isolates (47%) were detected and tested. The resistance rates were in %: Mecillinam (0.0), nitrofurantoin (0.7), fosfomycin trometamol (0.7), gentamycin (1.4), cefotaxime (2.7), ceftazidime (2.7), Cephadroxil (4.1) and ciprofloxacin (4.1). Higher resistance rates were found in amoxicillin/clavulanic acid (8.9), nalidixic acid (9.6), trimethoprim/sulphamethoxazole (14.4), trimethoprim (15.8), sulphamethoxazole (21.2) and ampicillin (28.8). Additionally, the comparison of these results with the results of the ECO·SENS study demonstrated an increase in resistance rates of ampicillin, amoxicillin/clavulanic acid, nalidixic acid and ciprofloxacin. Conclusions The resistance data for E. coli in uncomplicated UTIs in women gained by this study are the most recent data for this disease in Austria at the moment. The increased resistance rates of amoxicillin/clavulanic acid, ciprofloxacin and nalidixic acid should be respected when choosing an appropriate antibiotic for uncomplicated UTIs. The use of ampicillin, sulphamethoxazole, trimethoprim and trimethoprim/sulphametoxazole in uncomplicated UTIs in women should be questioned at all. The findings of this study should result in a regular surveillance system of resistances emerging in the ambulatory sector designed after the model of the EARS-Net. PMID:22989349

Meeting the educational and social needs of children with language impairment or autism spectrum disorder: the parents' perspectives.

PubMed

Lindsay, Geoff; Ricketts, Jessie; Peacey, Lindy V; Dockrell, Julie E; Charman, Tony

2016-09-01

There is increasing interest in examining the perspectives of parents of children with special educational needs (SEN). Exploring the view of parents of a child with language impairment (LI) or autism spectrum disorder (ASD) is particularly important because of their high prevalence, at over 30% of children with SEN in England, and the increasing evidence of overlapping profiles of their needs. To examine the similarities and differences between the perspectives of parents of children with LI or ASD on three issues: (1) their child's educational progress, and their behavioural, emotional and social development; (2) the provision made to support their child's education and meet their SEN; and (3) their own involvement in decision-making about provision for their child. The parents of 129 children with LI (n = 76) or ASD (n = 53) were interviewed using a semi-structured protocol that gathered both quantitative data (parent ratings) and qualitative, in-depth explorations of their perspectives. There were no significant differences between the perspectives of parents of children with LI and parents of children with ASD with respect to their child's educational progress; the provision made to meet their child's educational needs; or their involvement in decision-making during the statutory assessment procedure, including the determination of a statement of SEN, and the current provision made by their child's school. Both parent groups were generally positive about these but parents of children with ASD were more concerned about their child's peer relationships. Parents whose child attended a mainstream school with a specialist resource tended to be more positive about the provision made than parents whose child was included individually into a mainstream school. Although previous research indicates that parents of children with ASD are overrepresented among those who express dissatisfaction with the provision made to meet their child's needs, this study indicates high levels of satisfaction and overlap between the perspectives of parents of children with LI or ASD regarding their child's educational progress and their own involvement in decision-making about the child's provision. The findings indicate the importance for policy and practice of focusing on identified needs rather than diagnostic category; and the importance of practitioners and administrators engaging meaningfully with parents in collaborative decision-making. © 2016 Royal College of Speech and Language Therapists.

Modeling and modification of medical 3D objects. The benefit of using a haptic modeling tool.

PubMed

Kling-Petersen, T; Rydmark, M

2000-01-01

The Computer Laboratory of the medical faculty in Goteborg (Mednet) has since the end of 1998 been one of a limited numbers of participants in the development of a new modeling tool together with SensAble Technologies Inc [http:¿www.sensable.com/]. The software called SensAble FreeForm was officially released at Siggraph September 1999. Briefly, the software mimics the modeling techniques traditionally used by clay artists. An imported model or a user defined block of "clay" can be modified using different tools such as a ball, square block, scrape etc via the use of a SensAble Technologies PHANToM haptic arm. The model will deform in 3D as a result of touching the "clay" with any selected tool and the amount of deformation is linear to the force applied. By getting instantaneous haptic as well as visual feedback, precise and intuitive changes are easily made. While SensAble FreeForm lacks several of the features normally associated with a 3D modeling program (such as text handling, application of surface and bumpmaps, high-end rendering engines, etc) it's strength lies in the ability to rapidly create non-geometric 3D models. For medical use, very few anatomically correct models are created from scratch. However, FreeForm features tools enable advanced modification of reconstructed or 3D scanned models. One of the main problems with 3D laserscanning of medical specimens is that the technique usually leaves holes or gaps in the dataset corresponding to areas in shadows such as orifices, deep grooves etc. By using FreeForms different tools, these defects are easily corrected and gaps are filled out. Similarly, traditional 3D reconstruction (based on serial sections etc) often shows artifacts as a result of the triangulation and/or tessellation processes. These artifacts usually manifest as unnatural ridges or uneven areas ("the accordion effect"). FreeForm contains a smoothing algorithm that enables the user to select an area to be modified and subsequently apply any given amount of smoothing to the object. While the final objects need to be exported for further 3D graphic manipulation, FreeForm addresses one of the most time consuming problems of 3D modeling: modification and creation of non-geometric 3D objects.

Structural disorder of natural BimSen superlattices grown by molecular beam epitaxy

NASA Astrophysics Data System (ADS)

Springholz, G.; Wimmer, S.; Groiss, H.; Albu, M.; Hofer, F.; Caha, O.; Kriegner, D.; Stangl, J.; Bauer, G.; Holý, V.

2018-05-01

The structure and morphology of BimSen epitaxial layers with compositions ranging from Bi2Se3 to the Bi1Se1 grown by molecular beam epitaxy with different flux compositions are investigated by transmission electron microscopy, high-resolution x-ray diffraction, and atomic force microscopy. It is shown that the lattice structure changes significantly as a function of the beam flux composition, i.e., Se/BiSe flux ratio that determines the stoichiometry of the layers. A perfect Bi2Se3 phase is formed only with a sufficiently high additional Se flux, whereas Bi1Se1 is obtained when only a BiSe compound source without additional Se is used. For intermediate values of the excess Se flux during growth, Bi2Se3 -δ layers are obtained with the Se deficit δ varying between 0 and 1. This Se deficit is accommodated by incorporation of additional Bi-Bi double layers into the Bi2Se3 structure that otherwise exclusively consists of Se-Bi-Se-Bi-Se quintuple layers. While a periodic insertion of such Bi double layers would result in the formation of natural BimSen superlattices, we find that this Bi double-layer insertion is rather stochastic with a high degree of disorder depending on the film composition. Therefore, the structure of such epilayers is better described by a one-dimensional paracrystal model, consisting of disordered sequences of quintuple and double layers rather than by strictly periodic natural superlattices. From detailed analysis of the x-ray diffraction data, we determine the dependence of the lattice parameters a and c and distances of the individual (0001) planes dj as a function of composition, evidencing that only the in-plane lattice parameter a shows a linear dependence on composition. The simulation of the diffraction curves with the random stacking paracrystal model yields an excellent agreement with the experimental data and it brings quantitative information on the randomness of the stacking sequence, which is compared to growth modeling using Monte Carlo simulations. The analysis of transmission electron microscopy data furthermore confirms that the Bi-Bi bilayers contain a large amount of vacancies of up to 25%. Conductivity and Hall data confirm that BimSen phases containing Bi-Bi double layers exhibit a rather semimetallic behavior.

Model assessment of atmospheric pollution control schemes for critical emission regions

NASA Astrophysics Data System (ADS)

Zhai, Shixian; An, Xingqin; Liu, Zhao; Sun, Zhaobin; Hou, Qing

2016-01-01

In recent years, the atmospheric environment in portions of China has become significantly degraded and the need for emission controls has become urgent. Because more international events are being planned, it is important to implement air quality assurance targeted at significant events held over specific periods of time. This study sets Yanqihu (YQH), Beijing, the location of the 2014 Beijing APEC (Asia-Pacific Economic Cooperation) summit, as the target region. By using the atmospheric inversion model FLEXPART, we determined the sensitive source zones that had the greatest impact on the air quality of the YQH region in November 2012. We then used the air-quality model Models-3/CMAQ and a high-resolution emissions inventory of the Beijing-Tianjian-Hebei region to establish emission reduction tests for the entire source area and for specific sensitive source zones. This was achieved by initiating emission reduction schemes at different ratios and different times. The results showed that initiating a moderate reduction of emissions days prior to a potential event is more beneficial to the air quality of Beijing than initiating a high-strength reduction campaign on the day of the event. The sensitive source zone of Beijing (BJ-Sens) accounts for 54.2% of the total source area of Beijing (BJ), but its reduction effect reaches 89%-100% of the total area, with a reduction efficiency 1.6-1.9 times greater than that of the entire area. The sensitive source zone of Huabei (HuaB-Sens.) only represents 17.6% of the total area of Huabei (HuaB), but its emission reduction effect reaches 59%-97% of the entire area, with a reduction efficiency 4.2-5.5 times greater than that of the total area. The earlier that emission reduction measures are implemented, the greater the effect they have on preventing the transmission of pollutants. In addition, expanding the controlling areas to sensitive provinces and cities around Beijing (HuaB-sens) can significantly accelerate the reduction effects compared to controlling measures only in the Beijing sensitive source zone (BJ-Sens). Therefore, when enacting emission reduction schemes, cooperating with surrounding provinces and cities, as well as narrowing the reduction scope to specific sensitive source zones prior to unfavorable meteorological conditions, can help reduce emissions control costs and improve the efficiency and maneuverability of emission reduction schemes.

Evaluation of simulation-based training on the ability of birth attendants to correctly perform bimanual compression as obstetric first aid.

PubMed

Andreatta, Pamela; Gans-Larty, Florence; Debpuur, Domitilla; Ofosu, Anthony; Perosky, Joseph

2011-10-01

Maternal mortality from postpartum hemorrhage remains high globally, in large part because women give birth in rural communities where unskilled (traditional birth attendants) provide care for delivering mothers. Traditional attendants are neither trained nor equipped to recognize or manage postpartum hemorrhage as a life-threatening emergent condition. Recommended treatment includes using uterotonic agents and physical manipulation to aid uterine contraction. In resource-limited areas where Obstetric first aid may be the only care option, physical methods such as bimanual uterine compression are easily taught, highly practical and if performed correctly, highly effective. A simulator with objective performance feedback was designed to teach skilled and unskilled birth attendants to perform the technique. To evaluate the impact of simulation-based training on the ability of birth attendants to correctly perform bimanual compression in response to postpartum hemorrhage from uterine atony. Simulation-based training was conducted for skilled (N=111) and unskilled birth attendants (N=14) at two regional (Kumasi, Tamale) and two district (Savelugu, Sene) medical centers in Ghana. Training was evaluated using Kirkpatrick's 4-level model. All participants significantly increased their bimanual uterine compression skills after training (p=0.000). There were no significant differences between 2-week delayed post-test performances indicating retention (p=0.52). Applied behavioral and clinical outcomes were reported for 9 months from a subset of birth attendants in Sene District: 425 births, 13 postpartum hemorrhages were reported without concomitant maternal mortality. The results of this study suggest that simulation-based training for skilled and unskilled birth attendants to perform bi-manual uterine compression as postpartum hemorrhage Obstetric first aid leads to improved applied procedural skills. Results from a smaller subset of the sample suggest that these skills could potentially lead to improved clinical outcomes and additional study is merited. Copyright © 2011 Elsevier Ltd. All rights reserved.

Curriculum Design and Implementation of the Emergency Medicine Chief Resident Incubator.

PubMed

Gisondi, Michael A; Chou, Adaira; Joshi, Nikita; Sheehy, Margaret K; Zaver, Fareen; Chan, Teresa M; Riddell, Jeffrey; Sifford, Derek P; Lin, Michelle

2018-02-24

Background Chief residents receive minimal formal training in preparation for their administrative responsibilities. There is a lack of professional development programs specifically designed for chief residents. Objective In 2015, Academic Life in Emergency Medicine designed and implemented an annual, year-long, training program and virtual community of practice for chief residents in emergency medicine (EM). This study describes the curriculum design process and reports measures of learner engagement during the first two cycles of the curriculum. Methods Kern's Six-Step Approach for curriculum development informed key decisions in the design and implementation of the Chief Resident Incubator. The resultant curriculum was created using constructivist social learning theory, with specific objectives that emphasized the needs for a virtual community of practice, longitudinal content delivery, mentorship for participants, and the facilitation of multicenter digital scholarship. The 12-month curriculum included 11 key administrative or professional development domains, delivered using a combination of digital communications platforms. Primary outcomes measures included markers of learner engagement with the online curriculum, recognized as modified Kirkpatrick Level One outcomes for digital learning. Results An average of 206 chief residents annually enrolled in the first two years of the curriculum, with an overall participation by 33% (75/227) of the allopathic EM residency programs in the United States (U.S.). There was a high level of learner engagement, with an average 13,414 messages posted per year. There were also 42 small group teaching sessions held online, which included 39 faculty and 149 chief residents. The monthly e-newsletter had a 50.7% open rate. Digital scholarship totaled 23 online publications in two years, with 67 chief resident co-authors and 21 faculty co-authors. Conclusions The Chief Resident Incubator is a virtual community of practice that provides longitudinal training and mentorship for EM chief residents. This incubator conceptual framework may be used to design similar professional development curricula across various health professions using an online digital platform.

Curriculum Design and Implementation of the Emergency Medicine Chief Resident Incubator

PubMed Central

Chou, Adaira; Joshi, Nikita; Sheehy, Margaret K; Zaver, Fareen; Chan, Teresa M; Riddell, Jeffrey; Sifford, Derek P; Lin, Michelle

2018-01-01

Background Chief residents receive minimal formal training in preparation for their administrative responsibilities. There is a lack of professional development programs specifically designed for chief residents. Objective In 2015, Academic Life in Emergency Medicine designed and implemented an annual, year-long, training program and virtual community of practice for chief residents in emergency medicine (EM). This study describes the curriculum design process and reports measures of learner engagement during the first two cycles of the curriculum. Methods Kern’s Six-Step Approach for curriculum development informed key decisions in the design and implementation of the Chief Resident Incubator. The resultant curriculum was created using constructivist social learning theory, with specific objectives that emphasized the needs for a virtual community of practice, longitudinal content delivery, mentorship for participants, and the facilitation of multicenter digital scholarship. The 12-month curriculum included 11 key administrative or professional development domains, delivered using a combination of digital communications platforms. Primary outcomes measures included markers of learner engagement with the online curriculum, recognized as modified Kirkpatrick Level One outcomes for digital learning. Results An average of 206 chief residents annually enrolled in the first two years of the curriculum, with an overall participation by 33% (75/227) of the allopathic EM residency programs in the United States (U.S.). There was a high level of learner engagement, with an average 13,414 messages posted per year. There were also 42 small group teaching sessions held online, which included 39 faculty and 149 chief residents. The monthly e-newsletter had a 50.7% open rate. Digital scholarship totaled 23 online publications in two years, with 67 chief resident co-authors and 21 faculty co-authors. Conclusions The Chief Resident Incubator is a virtual community of practice that provides longitudinal training and mentorship for EM chief residents. This incubator conceptual framework may be used to design similar professional development curricula across various health professions using an online digital platform. PMID:29696101

Aquapath-Soil: Supporting farmers with hydrologic models and EO data

NASA Astrophysics Data System (ADS)

Chambel-Leitao, Pedro; Almeida, Carina; Jauch, Eduardo; Rosado, Hugo; Rocha, António; Leitão, José; Neves, Ramiro

2013-04-01

The AquaPath-Soil service (support to agricultural production) aims to provide support services for irrigation, based on the use of satellite images, hydrological models and meteorological data. Users can observe the project results through the website page (http://www.agro-evapo.eu) maps of Leaf Area Index (LAI), and animated maps of Actual Evapotranspiration (ETA) or receive SMS throughout the period with meteorological information and actual evapotranspiration. The service has been tested for a period of 3 years, and presently has about 80 pivot being covered by the service. The farmers evaluated positively the service and the service will continue in 2013. ETA maps are generated by MOHID LAND model and represent the evapotranspiration accumulated weekly throughout the growing period of maize between May and September, using LAI as input. Both this models (SWAT and MOHID LAND) calculate plant growth, actual evapotranspiration and soil moisture by explicitly calculating water balance of the system soil-plant-atmosphere. The information provided in the SMS is obtained through SWAT model running in forecast mode using meteorological data from the previous week and forecasts for the next week. The weather data is from the closest station of each field (precipitation, temperature, relative humidity, wind speed and solar radiation). The weather forecasts are obtained from the MM5 model (http://meteo.ist.utl.pt). Models and satellite images have been validated during this last three years using field measurements and farmers support. Main challenge of Aquapath-Soil service is the reduction of operational costs, mainly related with satellite acquisition and processing. The recently approved SenSyF FP7 project will implement a framework to obtain this aim. The SenSyF project proposes a complete system for fully automated data acquisition and processing. The SenSyF project provides a specialized Sandbox Service with tools and development/validation platforms where developers are able to implement and test their applications, and then tap into a distributed pool of cloud resources when ready for the exploitation phase. This project will allow for the development and testing of new processing chains and methods for Sentinel and GMES contributing mission data on a continuous basis, and the delivery of higher-level products and services complementing the information provided by the (pre-)operational services. This system will be based on a dynamic parallel processing infrastructure, where the capabilities of grid computing applied to Sentinel data processing can be exploited and demonstrated. The sandbox model furnishes a test environment very similar to the space agencies operational environments, where the applications are ran against large EO series of datasets, and where the "time- to-market" understood as the applications maturity and readiness for production can be streamlined. The distributed processing services are bridging the exploitation gap by offering access to EO data and processing power, and bringing the processors and applications closer to the data. By using the same model behind the European Space Agency (ESA) Grid Processing on-Demand environment, the SenSyF project will enable the collaborative sharing of data and processing power from commercial or/and private clouds. The SenSyF project will provide an infrastructure where SME and scientists can develop and deploy Earth Science application with a lower overall cost of data and infrastructure setup and maintenance. On top of the Synergy Framework being proposed, a selected set of demonstrative services were selected, which will 1) demonstrate the system's potential, 2) provide valuable development feedback for the framework improvement, and 3) prove the overall concept by addressing specific services needs within the European and global setting. Aquapath-Soil is one of the services to be included in SenSyF Framework.

Exposure to Air Pollution Enhances the Generation of Vascular Microparticles

EPA Science Inventory

Epidemiological studies associate exposure to ambient levels of particulate matter (PM) with cardiovascular morbidity and mortality. The biological mechanisms by which PM exposure induces cardiovascular effects remain to be elucidated. One important limitation is the lack of sens...

Development of a time-dependent hurricane evacuation model for the New Orleans area.

DOT National Transportation Integrated Search

2013-01-01

Revealed preference is the traditional method to collect hurricane evacuation behavior data. However, revealed preference surveys, as they are currently administered, have the disadvantage that they are unable to collect time-sensitive and policy-sen...

Weigh-in-Motion Sensor and Controller Operation and Performance Comparison

DOT National Transportation Integrated Search

2018-01-01

This research project utilized statistical inference and comparison techniques to compare the performance of different Weigh-in-Motion (WIM) sensors. First, we analyzed test-vehicle data to perform an accuracy check of the results reported by the sen...

Investigation of fugitive emissions from petrochemical transport barges using optical remote sensing

EPA Science Inventory

Recent airborne remote sensing survey data acquired with passive gas imaging equipment (PGIE), in this case infrared cameras, have shown potentially significant fugitive volatile organic carbon (VOC) emissions from petrochemical transport barges. The experiment found remote sens...

Long-Term Structural Performance Monitoring of Bridges : Hardware Maintenance and, Long-term Data Collection/Analysis

DOT National Transportation Integrated Search

2011-06-01

In this project a description of the maintenance of the sensor monitoring systems installed on three California : highway bridges is presented. The monitoring systems consist of accelerometers, strain gauges, pressure sensors, : and displacement sens...

Long-term structural performance monitoring of bridges : hardware maintenance and, long-term data collection/analysis.

DOT National Transportation Integrated Search

2011-06-01

In this project a description of the maintenance of the sensor monitoring systems installed on three California : highway bridges is presented. The monitoring systems consist of accelerometers, strain gauges, pressure sensors, : and displacement sens...

1300243

NASA Image and Video Library

2013-04-18

Alabama Gov. Robert Bentley signs a proclamation declaring April 18, 2013, "NASA Day in Alabama." Looking on, from left, are Marshall Space Flight Center Director Patrick Scheuermann, astronauts Kathleen "Kate" Rubins and Jack Fischer, and State Sen. Bill Holtzclaw of Madison, who represents Madison and Limestone counties.

The Matter with Listening Comprehension Isn't the Ear: Hardware and Software.

ERIC Educational Resources Information Center

Harvey, T. Edward

1978-01-01

Reviews some technological advances and classroom games which may be used to increase listening comprehension skills in the foreign language classroom. These include the Random Access Memory (RAM), the Sens-it-Cell, and the SCUCHO game. (AM)

Annual Progress Report, FY 1980 (U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD)

DTIC Science & Technology

1980-10-01

Detrick, MD 21701 Fort Detrick, MD 21701 PW 44.p UW ~$" TOM r,ý 8i It V &. A ý 0.00"UAL wmwo* Anderson, A. 0. Barquist, R. F. IWLEPMgo: 301 663-7211 S301...Antiviral Agent (R. A. Smith and W. Kirkpatrick, eds). Academic Press, New York. 10i RESIAMO A14D TECNOOGY W=~ UW SUMAMY DA 0G6427 80 10 01 DOD96Z&(AR)OJ6 L...Defense; 010100 Microbiology 77 10 80 0Q*..... C. In-house I, a* 010WOA a"Isb-Ws ?A I5T V -WLAL 8 1.0 121 VONA We"J lo of 444 C UW S". 0MY 0 S USA

Pediatric radiology in the Philadelphia region: a history of pedigrees and legacies.

PubMed

Markowitz, Richard I

2009-09-01

The specialty of pediatric radiology in the Philadelphia region has grown and evolved over the past eight decades originating from early "visiting" radiologists to Drs. Hope and Kirkpatrick, the "giants" of the 1950s and 1960s, to over 40 actively practicing pediatric radiologists. Clinical excellence, commitment to teaching, and advancement of knowledge through research remain the goals and ideals, much as they were many years ago. Philadelphia has been a fertile home and environment for this development, mostly because of outstanding leaders and role models who have trained and influenced generations of pediatric radiologists. The purpose of this article is to tell the story of this growth and development and to explore the intellectual origins, professional "genealogy," and legacies left by those who created this tradition.

Imaging Research With Non-Periodic Multilayers for Inertial Confinement Fusion Diagnostic Experiments

NASA Astrophysics Data System (ADS)

L. Wang, F.; Mu, B. Z.; Wang, Z. S.; Gu, C. S.; Zhang, Z.; Qin, S. J.; Chen, L. Y.

A grazing Kirkpatrick-Baez (K-B) microscope was designed for hard x-ray (8keV; Cu Ka radiation) imaging in Inertial Confinement Fusion (ICF) diagnostic experiments. Ray tracing software was used to simulate optical system performance. The optimized theoretical resolution of K-B microscope was about 2 micron and better than 10 micron in 200 micron field of view. Tungsten and boron carbide were chosen as multilayer materials and the multilayer was deposited onto the silicon wafer substrate and the reflectivity was measured by x-ray diffraction (XRD). The reflectivity of supermirror was about 20 % in 0.3 % of bandwidth. 8keV Cu target x-ray tube source was used in x-ray imaging experiments and the magnification of 1x and 2x x-ray images were obtained.

On the TAP Free Energy in the Mixed p-Spin Models

NASA Astrophysics Data System (ADS)

Chen, Wei-Kuo; Panchenko, Dmitry

2018-05-01

Thouless et al. (Phys Mag 35(3):593-601, 1977), derived a representation for the free energy of the Sherrington-Kirkpatrick model, called the TAP free energy, written as the difference of the energy and entropy on the extended configuration space of local magnetizations with an Onsager correction term. In the setting of mixed p-spin models with Ising spins, we prove that the free energy can indeed be written as the supremum of the TAP free energy over the space of local magnetizations whose Edwards-Anderson order parameter (self-overlap) is to the right of the support of the Parisi measure. Furthermore, for generic mixed p-spin models, we prove that the free energy is equal to the TAP free energy evaluated on the local magnetization of any pure state.

Performance of NucliSens HIV-1 EasyQ Version 2.0 compared with six commercially available quantitative nucleic acid assays for detection of HIV-1 in China.

PubMed

Xu, Sihong; Song, Aijing; Nie, Jianhui; Li, Xiuhua; Wang, Youchun

2010-10-01

Six HIV-1 viral load assays have been widely used in China. These include the Cobas Amplicor HIV-1 Monitor Version 1.5 ('Amplicor'), Cobas AmpliPrep/Cobas TaqMan HIV-1 test Version 1.0 ('CAP/CTM'), Versant HIV-1 RNA Version 3.0 (branched DNA [bDNA]-based assay; 'Versant bDNA'), Abbott RealTime HIV-1 assay ('Abbott RealTime'), NucliSens HIV-1 QT (nucleic acid sequence-based amplification assay; 'NucliSens NASBA'), and NucliSens EasyQ HIV-1 Version 1.1 ('EasyQ V1.1'). Recently, an updated version of EasyQ V1.1, NucliSens EasyQ HIV-1 Version 2.0 ('EasyQ V2.0') was introduced into China. It is important to evaluate the impact of HIV-1 genotypes on the updated assay compared with the other commercial available assays in China. A total of 175 plasma samples with different HIV-1 clades prevalent in China were collected from treatment-naïve patients. The viral loads of those samples were determined with the seven HIV-1 viral load assays, and the quantitative differences between them were evaluated. Overall, EasyQ V2.0 exhibited a significant correlation (R = 0.769-0.850, p ≤ 0.001) and high agreement (94.77-97.13%, using the Bland-Altman model) with the other six assays. Although no significant differences between EasyQ V2.0 and the other six assays were observed when quantifying clade B' samples, there were statistically significant differences between EasyQ V2.0 and the Amplicor, Versant bDNA, and Abbott RealTime assays when quantifying clade BC samples, and between EasyQ V2.0 and the Versant bDNA and Abbott RealTime assays when quantifying clade AE samples. For clade BC samples, the quantitative differences between EasyQ V2.0 and the Amplicor, Versant bDNA, and Abbott RealTime assays exceeded 0.5 log(10) IU/mL in approximately 50% of samples and exceeded 1 log(10) IU/mL in approximately 15% of samples. For clade AE samples, the quantitative differences between EasyQ V2.0 and the CAP/CTM, Versant bDNA, and Abbott RealTime assays exceeded 0.5 log(10) IU/mL in approximately 50% of samples, and the differences between EasyQ V2.0 and CAP/CTM exceeded 1 log(10) IU/mL in approximately 15% of samples. Genotypes may affect the quantification of HIV-1 RNA, especially in clade BC samples with respect to EasyQ V2.0 and the Amplicor, Versant bDNA, or Abbott RealTime assays, and in clade AE samples with respect to EasyQ V2.0 and the Versant bDNA or Abbott RealTime assays. It is therefore strongly suggested that, where possible, the HIV-1 viral load in infected patients be quantified at follow-up by the same version of the same assay that was used initially.

Mycobacterium tuberculosis PhoY Proteins Promote Persister Formation by Mediating Pst/SenX3-RegX3 Phosphate Sensing.

PubMed

Namugenyi, Sarah B; Aagesen, Alisha M; Elliott, Sarah R; Tischler, Anna D

2017-07-11

The Mycobacterium tuberculosis phosphate-specific transport (Pst) system controls gene expression in response to phosphate availability by inhibiting the activation of the SenX3-RegX3 two-component system under phosphate-rich conditions, but the mechanism of communication between these systems is unknown. In Escherichia coli , inhibition of the two-component system PhoR-PhoB under phosphate-rich conditions requires both the Pst system and PhoU, a putative adaptor protein. E. coli PhoU is also involved in the formation of persisters, a subpopulation of phenotypically antibiotic-tolerant bacteria. M. tuberculosis encodes two PhoU orthologs, PhoY1 and PhoY2. We generated phoY single- and double-deletion mutants and examined the expression of RegX3-regulated genes by quantitative reverse transcription-PCR (qRT-PCR). Gene expression was increased only in the Δ phoY1 Δ phoY2 double mutant and could be restored to the wild-type level by complementation with either phoY1 or phoY2 or by deletion of regX3 These data suggest that the PhoY proteins function redundantly to inhibit SenX3-RegX3 activation. We analyzed the frequencies of antibiotic-tolerant persister variants in the phoY mutants using several antibiotic combinations. Persister frequency was decreased at least 40-fold in the Δ phoY1 Δ phoY2 mutant compared to the frequency in the wild type, and this phenotype was RegX3 dependent. A Δ pstA1 mutant lacking a Pst system transmembrane component exhibited a similar RegX3-dependent decrease in persister frequency. In aerosol-infected mice, the Δ phoY1 Δ phoY2 and Δ pstA1 mutants were more susceptible to treatment with rifampin but not isoniazid. Our data demonstrate that disrupting phosphate sensing mediated by the PhoY proteins and the Pst system enhances the susceptibility of M. tuberculosis to antibiotics both in vitro and during infection. IMPORTANCE Persister variants, subpopulations of bacteria that are phenotypically antibiotic tolerant, contribute to the lengthy treatment times required to cure Mycobacterium tuberculosis infection, but the molecular mechanisms governing their formation and maintenance are poorly characterized. Here, we demonstrate that a phosphate-sensing signal transduction system, comprising the Pst phosphate transporter, the two-component system SenX3-RegX3, and functionally redundant PhoY proteins that mediate signaling between Pst and SenX3-RegX3, influences persister formation. Activation of RegX3 by deletion of the phoY genes or a Pst system component resulted in decreased persister formation in vitro Activated RegX3 also limited persister formation during growth under phosphate-limiting conditions. Importantly, increased susceptibility to the front-line drug rifampin was also observed in a mouse infection model. Thus, the M. tuberculosis phosphate-sensing signal transduction system contributes to antibiotic tolerance and is a potential target for the development of novel therapeutics that may shorten the duration of tuberculosis treatment. Copyright © 2017 Namugenyi et al.

Facing an Uncertain Future.

DTIC Science & Technology

1982-01-01

apparent coincidence that the same normalization should do for time and uncertainty with Kenneth Arrow, Michael Boskin, Frank Hahn, Hugh Rose, Amartya ... Sen , and John Wise at various times, and the possible relationship between the structure of a criterion function and an information tree such as that

Applying Molecular Tools for Monitoring Inhibition of Nitrification by Heavy Metals

EPA Science Inventory

The biological removal of ammonia in conventional wastewater treatment plants (WWTPs) is performed by promoting nitrification and denitrification as sequential steps. The first step in nitrification, the oxidation of ammonia to nitrite by ammonia oxidizing bacteria (AOB), is sens...

Bridenstine Sworn In As NASA Administrator

NASA Image and Video Library

2018-04-23

Sen. Ted Cruz, R-Texas, takes a picture of Vice President Mike Pence as he speaks prior to the swearing-in of Jim Bridenstine as the 13th NASA Administrator, Monday, April 23, 2018 at NASA Headquarters in Washington. Photo Credit: (NASA/Joel Kowsky)

Vertical integration from the large Hilbert space

NASA Astrophysics Data System (ADS)

Erler, Theodore; Konopka, Sebastian

2017-12-01

We develop an alternative description of the procedure of vertical integration based on the observation that amplitudes can be written in BRST exact form in the large Hilbert space. We relate this approach to the description of vertical integration given by Sen and Witten.

sts119-s-041

NASA Image and Video Library

2009-03-24

President Barack Obama is joined by members of Congress, including former astronaut Sen. Bill Nelson, right, and school children as he talks Tuesday, March 24, 2009, with astronauts on the International Space Station from the Roosevelt Room at the White House. (White House Photo/Pete Souza)