Ultrasonic transducer

DOEpatents

Taylor, Steven C.; Kraft, Nancy C.

2007-03-13

An ultrasonic transducer having an effective center frequency of about 42 MHz; a bandwidth of greater than 85% at 6 dB; a spherical focus of at least 0.5 inches in water; an F4 lens; a resolution sufficient to be able to detect and separate a 0.005 inch flat-bottomed hole at 0.005 inches below surface; and a beam size of approximately 0.006–0.008 inches measured off a 11/2 mm ball in water at the transducer's focal point.

Apparatus and method using a holographic optical element for converting a spectral distribution to image points

NASA Technical Reports Server (NTRS)

McGill, Matthew J. (Inventor); Scott, Vibart S. (Inventor); Marzouk, Marzouk (Inventor)

2001-01-01

A holographic optical element transforms a spectral distribution of light to image points. The element comprises areas, each of which acts as a separate lens to image the light incident in its area to an image point. Each area contains the recorded hologram of a point source object. The image points can be made to lie in a line in the same focal plane so as to align with a linear array detector. A version of the element has been developed that has concentric equal areas to match the circular fringe pattern of a Fabry-Perot interferometer. The element has high transmission efficiency, and when coupled with high quantum efficiency solid state detectors, provides an efficient photon-collecting detection system. The element may be used as part of the detection system in a direct detection Doppler lidar system or multiple field of view lidar system.

Single lens laser beam shaper

DOEpatents

Liu, Chuyu [Newport News, VA; Zhang, Shukui [Yorktown, VA

2011-10-04

A single lens bullet-shaped laser beam shaper capable of redistributing an arbitrary beam profile into any desired output profile comprising a unitary lens comprising: a convex front input surface defining a focal point and a flat output portion at the focal point; and b) a cylindrical core portion having a flat input surface coincident with the flat output portion of the first input portion at the focal point and a convex rear output surface remote from the convex front input surface.

Influence of the distance between target surface and focal point on the expansion dynamics of a laser-induced silicon plasma with spatial confinement

NASA Astrophysics Data System (ADS)

Zhang, Dan; Chen, Anmin; Wang, Xiaowei; Wang, Ying; Sui, Laizhi; Ke, Da; Li, Suyu; Jiang, Yuanfei; Jin, Mingxing

2018-05-01

Expansion dynamics of a laser-induced plasma plume, with spatial confinement, for various distances between the target surface and focal point were studied by the fast photography technique. A silicon wafer was ablated to induce the plasma with a Nd:YAG laser in an atmospheric environment. The expansion dynamics of the plasma plume depended on the distance between the target surface and focal point. In addition, spatially confined time-resolved images showed the different structures of the plasma plumes at different distances between the target surface and focal point. By analyzing the plume images, the optimal distance for emission enhancement was found to be approximately 6 mm away from the geometrical focus using a 10 cm focal length lens. This optimized distance resulted in the strongest compression ratio of the plasma plume by the reflected shock wave. Furthermore, the duration of the interaction between the reflected shock wave and the plasma plume was also prolonged.

Economic principles in communication: an experimental study.

PubMed

De Jaegher, Kris; Rosenkranz, Stephanie; Weitzel, Utz

2014-12-21

This paper experimentally investigates how economic principles affect communication. In a simple sender-receiver game with common interests over payoffs, the sender can send a signal without a pre-given meaning in an infrequent or frequent state of the world. When the signal is costly, several theories (focal point theory, the intuitive criterion, evolutionary game theory) predict an efficient separating equilibrium, where the signal is sent in the infrequent state of the world (also referred to as Horn׳s rule). To analyze whether Horn׳s rule applies, and if so, which theory best explains it, we develop and test variants of the sender-receiver game where the theories generate discriminatory hypotheses. In costly signaling variants, our participants follow Horn׳s rule most of the time, in a manner that is best explained by focal point theory. In costless signaling variants, evolutionary game theory best explains our results. Here participants coordinate significantly more (less) often on a separating equilibrium where the signal is sent in the frequent state if they are primed to associate the absence of a signal with the infrequent (frequent) state of the world. We also find indications that a similar priming effect applies to costly signals. Thus, while the frequency with which participants follow Horn׳s rule in costly signaling variants is best explained by Horn׳s rule, the priming effect shows that some of our participants׳ behavior is best explained by evolutionary game theory even when signals are costly. Copyright © 2014 Elsevier Ltd. All rights reserved.

Acoustooptic pulse-echo transducer system

NASA Technical Reports Server (NTRS)

Claus, R. O.; Wade, J. C.

1983-01-01

A pulse-echo transducer system which uses an ultrasonic generating element and an optical detection technique is described. The transmitting transducer consists of a concentric ring electrode pattern deposited on a circular, X-cut quartz substrate with a circular hole in the center. The rings are independently pulsed with a sequence high voltage signals phased in such a way that the ultrasonic waves generated by the separate rings superimpose to produce a composite field which is focused at a controllable distance below the surface of the specimen. The amplitude of the field reflected from this focus position is determined by the local reflection coefficient of the medium at the effective focal point. By processing the signals received for a range of ultrasonic transducer array focal lengths, the system can be used to locate and size anomalies within solids and liquids. Applications in both nondestructive evaluation and biomedical scanning are suggested.

Dynamic propagation of symmetric Airy pulses with initial chirps in an optical fiber

NASA Astrophysics Data System (ADS)

Shi, Xiaohui; Huang, Xianwei; Deng, Yangbao; Tan, Chao; Bai, Yanfeng; Fu, Xiquan

2017-09-01

We analytically and numerically investigate the propagation dynamics of initially chirped symmetric Airy pulses in an optical fiber. The results show that the positive chirps act to promote the interference in generating a focal point on the propagation axis, while the negative chirps tend to suppress the focusing effect, as compared to conventional unchirped symmetric Airy pulses. The numerical results demonstrate that the linear propagation of chirped symmetric Airy pulses depend considerably on the chirp parameter and the primary lobe position. In the anomalous dispersion region, positively chirped symmetric Airy pulses first undergo an initial compression, and reach a foci due to the opposite acceleration, and then experience a lossy inversion transformation, and come to the opposite facing focal position. The impact of truncation coefficient and Kerr nonlinearity on the chirped symmetric Airy pulses propagation is also disclosed separately.

Effect of defocusing on laser ablation plume observed by laser-induced fluorescence imaging spectroscopy

NASA Astrophysics Data System (ADS)

Oba, Masaki; Miyabe, Masabumi; Akaoka, Katsuaki; Wakaida, Ikuo

2016-02-01

We used laser-induced fluorescence imaging with a varying beam focal point to observe ablation plumes from metal and oxide samples of gadolinium. The plumes expand vertically when the focal point is far from the sample surface. In contrast, the plume becomes hemispherical when the focal point is on the sample surface. In addition, the internal plume structure and the composition of the ablated atomic and ionic particles also vary significantly. The fluorescence intensity of a plume from a metal sample is greater than that from an oxide sample, which suggests that the number of monatomic species produced in each plume differs. For both the metal and oxide samples, the most intense fluorescence from atomic (ionic) species is observed with the beam focal point at 3-4 mm (2 mm) from the sample surface.

Force direction patterns promote whole body stability even in hip-flexed walking, but not upper body stability in human upright walking

NASA Astrophysics Data System (ADS)

Müller, Roy; Rode, Christian; Aminiaghdam, Soran; Vielemeyer, Johanna; Blickhan, Reinhard

2017-11-01

Directing the ground reaction forces to a focal point above the centre of mass of the whole body promotes whole body stability in human and animal gaits similar to a physical pendulum. Here we show that this is the case in human hip-flexed walking as well. For all upper body orientations (upright, 25°, 50°, maximum), the focal point was well above the centre of mass of the whole body, suggesting its general relevance for walking. Deviations of the forces' lines of action from the focal point increased with upper body inclination from 25 to 43 mm root mean square deviation (RMSD). With respect to the upper body in upright gait, the resulting force also passed near a focal point (17 mm RMSD between the net forces' lines of action and focal point), but this point was 18 cm below its centre of mass. While this behaviour mimics an unstable inverted pendulum, it leads to resulting torques of alternating sign in accordance with periodic upper body motion and probably provides for low metabolic cost of upright gait by keeping hip torques small. Stabilization of the upper body is a consequence of other mechanisms, e.g. hip reflexes or muscle preflexes.

Argonne Today

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Multiple wavelength X-ray monochromators

DOEpatents

Steinmeyer, P.A.

1992-11-17

An improved apparatus and method is provided for separating input x-ray radiation containing first and second x-ray wavelengths into spatially separate first and second output radiation which contain the first and second x-ray wavelengths, respectively. The apparatus includes a crystalline diffractor which includes a first set of parallel crystal planes, where each of the planes is spaced a predetermined first distance from one another. The crystalline diffractor also includes a second set of parallel crystal planes inclined at an angle with respect to the first set of crystal planes where each of the planes of the second set of parallel crystal planes is spaced a predetermined second distance from one another. In one embodiment, the crystalline diffractor is comprised of a single crystal. In a second embodiment, the crystalline diffractor is comprised of a stack of two crystals. In a third embodiment, the crystalline diffractor includes a single crystal that is bent for focusing the separate first and second output x-ray radiation wavelengths into separate focal points. 3 figs.

Multiple wavelength X-ray monochromators

DOEpatents

Steinmeyer, Peter A.

1992-11-17

An improved apparatus and method is provided for separating input x-ray radiation containing first and second x-ray wavelengths into spatially separate first and second output radiation which contain the first and second x-ray wavelengths, respectively. The apparatus includes a crystalline diffractor which includes a first set of parallel crystal planes, where each of the planes is spaced a predetermined first distance from one another. The crystalline diffractor also includes a second set of parallel crystal planes inclined at an angle with respect to the first set of crystal planes where each of the planes of the second set of parallel crystal planes is spaced a predetermined second distance from one another. In one embodiment, the crystalline diffractor is comprised of a single crystal. In a second embodiment, the crystalline diffractor is comprised of a stack of two crystals. In a third embodiment, the crystalline diffractor includes a single crystal that is bent for focussing the separate first and second output x-ray radiation wavelengths into separate focal points.

Sighting optics including an optical element having a first focal length and a second focal length

DOEpatents

Crandall, David Lynn [Idaho Falls, ID

2011-08-01

One embodiment of sighting optics according to the teachings provided herein may include a front sight and a rear sight positioned in spaced-apart relation. The rear sight includes an optical element having a first focal length and a second focal length. The first focal length is selected so that it is about equal to a distance separating the optical element and the front sight and the second focal length is selected so that it is about equal to a target distance. The optical element thus brings into simultaneous focus, for a user, images of the front sight and the target.

Sighting optics including an optical element having a first focal length and a second focal length and methods for sighting

DOEpatents

Crandall, David Lynn

2011-08-16

Sighting optics include a front sight and a rear sight positioned in a spaced-apart relation. The rear sight includes an optical element having a first focal length and a second focal length. The first focal length is selected so that it is about equal to a distance separating the optical element and the front sight and the second focal length is selected so that it is about equal to a target distance. The optical element thus brings into simultaneous focus for a user images of the front sight and the target.

Method for chemically analyzing a solution by acoustic means

DOEpatents

Beller, Laurence S.

1997-01-01

A method and apparatus for determining a type of solution and the concention of that solution by acoustic means. Generally stated, the method consists of: immersing a sound focusing transducer within a first liquid filled container; locating a separately contained specimen solution at a sound focal point within the first container; locating a sound probe adjacent to the specimen, generating a variable intensity sound signal from the transducer; measuring fundamental and multiple harmonic sound signal amplitudes; and then comparing a plot of a specimen sound response with a known solution sound response, thereby determining the solution type and concentration.

Point Relay Scanner Utilizing Ellipsoidal Mirrors

NASA Technical Reports Server (NTRS)

Manhart, Paul K. (Inventor); Pagano, Robert J. (Inventor)

1997-01-01

A scanning system uses a polygonal mirror assembly with each facet of the polygon having an ellipsoidal mirror located thereon. One focal point of each ellipsoidal mirror is located at a common point on the axis of rotation of the polygonal mirror assembly. As the mirror assembly rotates. a second focal point of the ellipsoidal mirrors traces out a scan line. The scanner can be utilized for scanned output display of information or for scanning information to be detected.

Lydia Finney appointed WIST program initiator - Argonne Today

Science.gov Websites

Home Mission People Work/Life Connections Focal Point Inside Argonne Argonne Public Website Argonne Today Argonne Today Mission People Work/Life Connections Focal Point Lydia Finney appointed WIST program initiator Home People Lydia Finney appointed WIST program initiator Lydia Finney appointed WIST

Continuously variable focal length lens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Bernhard W; Chollet, Matthieu C

2013-12-17

A material preferably in crystal form having a low atomic number such as beryllium (Z=4) provides for the focusing of x-rays in a continuously variable manner. The material is provided with plural spaced curvilinear, optically matched slots and/or recesses through which an x-ray beam is directed. The focal length of the material may be decreased or increased by increasing or decreasing, respectively, the number of slots (or recesses) through which the x-ray beam is directed, while fine tuning of the focal length is accomplished by rotation of the material so as to change the path length of the x-ray beammore » through the aligned cylindrical slows. X-ray analysis of a fixed point in a solid material may be performed by scanning the energy of the x-ray beam while rotating the material to maintain the beam's focal point at a fixed point in the specimen undergoing analysis.« less

Physical Activity Performance of Focal Middle School Students

ERIC Educational Resources Information Center

Erfle, Stephen E.; Gelbaugh, Corey M.

2013-01-01

Histograms of push-ups and curl-ups from a sample of more than 9,000 students show periodic spikes at five and 10 unit intervals. This article argues that these spikes are related to focal points, a game theoretic concept popularized by Nobel Laureate Thomas Schelling. Being focal on one test makes one more likely to be focal on the other. Focal…

Focal points and principal solutions of linear Hamiltonian systems revisited

NASA Astrophysics Data System (ADS)

Šepitka, Peter; Šimon Hilscher, Roman

2018-05-01

In this paper we present a novel view on the principal (and antiprincipal) solutions of linear Hamiltonian systems, as well as on the focal points of their conjoined bases. We present a new and unified theory of principal (and antiprincipal) solutions at a finite point and at infinity, and apply it to obtain new representation of the multiplicities of right and left proper focal points of conjoined bases. We show that these multiplicities can be characterized by the abnormality of the system in a neighborhood of the given point and by the rank of the associated T-matrix from the theory of principal (and antiprincipal) solutions. We also derive some additional important results concerning the representation of T-matrices and associated normalized conjoined bases. The results in this paper are new even for completely controllable linear Hamiltonian systems. We also discuss other potential applications of our main results, in particular in the singular Sturmian theory.

Noncontact Tactile Display Based on Radiation Pressure of Airborne Ultrasound.

PubMed

Hoshi, T; Takahashi, M; Iwamoto, T; Shinoda, H

2010-01-01

This paper describes a tactile display which provides unrestricted tactile feedback in air without any mechanical contact. It controls ultrasound and produces a stress field in a 3D space. The principle is based on a nonlinear phenomenon of ultrasound: Acoustic radiation pressure. The fabricated prototype consists of 324 airborne ultrasound transducers, and the phase and intensity of each transducer are controlled individually to generate a focal point. The DC output force at the focal point is 16 mN and the diameter of the focal point is 20 mm. The prototype produces vibrations up to 1 kHz. An interaction system including the prototype is also introduced, which enables users to see and touch virtual objects.

A lab-on-phone instrument with varifocal microscope via a liquid-actuated aspheric lens (LAL)

PubMed Central

Fuh, Yiin-Kuen; Lai, Zheng-Hong; Kau, Li-Han; Huang, Hung-Jui

2017-01-01

In this paper, we introduce a novel concept of liquid-actuated aspheric lens (LAL) with a built-in aspheric polydimethylsiloxane lens (APL) to enable the design of compact optical systems with varifocal microscopic imaging. The varifocal lens module consists of a sandwiched structures such as 3d printed syringe pump functionally serves as liquid controller. Other key components include two acrylic cylinders, a rigid separator, a APL/membrane composite (APLMC) embedded PDMS membrane. In functional operation, the fluidic controller was driven to control the pressure difference and ALPMC deformation. The focal length can be changed through the pressure difference. This is achieved by the adjustment of volume change of injected liquid such that a widely tunable focal length. The proposed LAL can transform to 3 modes: microscopic mode (APLMC only), convex-concave mode and biconcave mode. It is noticeable that LAL in the operation of microscopic mode is tunable in focus via the actuation of APLMC (focal length is from 4.3 to 2.3 mm and magnification 50X) and can rival the images quality of commercial microscopes. A new lab-on-phone device is economically feasible and functionally versatile to offer a great potential in the point of care applications. PMID:28650971

Focal Points, Endogenous Processes, and Exogenous Shocks in the Autism Epidemic

ERIC Educational Resources Information Center

Liu, Kayuet; Bearman, Peter S.

2015-01-01

Autism prevalence has increased rapidly in the United States during the past two decades. We have previously shown that the diffusion of information about autism through spatially proximate social relations has contributed significantly to the epidemic. This study expands on this finding by identifying the focal points for interaction that drive…

Women in Energy: Rinku Gupta - Argonne Today

Science.gov Websites

Home Mission People Work/Life Connections Focal Point Inside Argonne Argonne Public Website Argonne Today Argonne Today Mission People Work/Life Connections Focal Point Women in Energy: Rinku Gupta Home People Women in Energy: Rinku Gupta Women in Energy: Rinku Gupta Apr 1, 2016 | Posted by Argonne

Measles elimination – review of event notifications sent to National IHR Focal Point between 2010 and 2016

PubMed

Izdebski, Radosław; Henszel, Łukasz; Janiec, Janusz; Radziszewski, Franciszek

The Member States of the World Health Organization (WHO) in accordance with International Health Regulations (2005) were obliged to appoint National IHR Focal Points (N IHR FP), of which tasks include obtaining information concerning public health emergencies of international concern which occurred abroad or within the country. The aim of this work is the review of WHO, ECDC, National IHR Focal Points from the WHO Member States and The State Sanitary Inspection notifications related to measles received by National IHR Focal Point in Poland in the period from 2010 to 2016. During this period N IHR FP was informed about 79 events related to measles. These events include: 36 related to the outbreaks in different countries, 27 concerning individual cases, 14 related to the exposure in contact with a measles case during air travel and two concerning the implementation of the MMR vaccination programs. Despite the progress in implementing the measures included in the elimination of measles programs in Europe, there was a significant increase in the number of measles cases and outbreaks particularly in years 2010-2011.

Aristotle's illusion reveals interdigit functional somatosensory alterations in focal hand dystonia.

PubMed

Tinazzi, Michele; Marotta, Angela; Fasano, Alfonso; Bove, Francesco; Bentivoglio, Anna Rita; Squintani, Giovanna; Pozzer, Lara; Fiorio, Mirta

2013-03-01

In focal hand dystonia, the cortical somatosensory representation of the fingers is abnormal, with overlapping receptive fields and reduced interdigit separation. These abnormalities are associated with deficits in sensory perception, as previously demonstrated by applying tactile stimuli to one finger at a time. What is still unknown is whether the sensory deficits can be observed when tactile perception involves more than one finger. To address this issue, we applied 'Aristotle's illusion' to 15 patients with focal hand dystonia, 15 patients with dystonia not affecting the hand (blepharospasm and cervical dystonia) and 15 healthy control subjects. In this illusion, one object touching the contact point of two crossed fingertips is perceived as two objects by a blindfolded subject. The same object placed between two parallel fingertips is correctly perceived as one. The illusory doubling sensation is because of the fact that the contact point between the crossed fingers consists of non-adjacent and functionally unrelated skin regions, which usually send sensory signals to separate spots in the somatosensory cortex. In our study, participants were touched by one sphere between the second-third digits, the second-fourth digits and the fourth-fifth digits of both hands, either in crossed or in parallel position, and had to refer whether they felt one or two stimuli. The percentage of 'two stimuli' responses was an index of the illusory doubling. Both healthy control subjects and dystonic patients presented Aristotle's illusion when the fingers were crossed. However, patients with focal hand dystonia presented a significant reduction of the illusion when the sphere was placed between the crossed fourth and fifth digits of the affected hand. This reduction correlated with the severity of motor disease at the fingers. Similar findings were not observed in non-hand dystonia and control groups. The reduction of Aristotle's illusion in non-affected fingers and its preservation in affected fingers suggests dissociation between the abnormal processing of sensory signals and the motor impairment. Based on previous evidence showing that the sensory signals coming from the fourth digit determine lower activation in the somatosensory cortex than those coming from the fifth digit, we suggest that in the crossed position, the tactile information conveyed by the fifth digit prevailed over the fourth digit, thus resulting in the perception of one stimulus. The reduction of the illusory doubling perception, therefore, may represent the functional correlate of the different level of activation between the fourth and the fifth digit in the somatosensory cortex.

Manifestations Of Mine-induced Seismicity At Large-scale Mining Operations In Khibiny Massive

NASA Astrophysics Data System (ADS)

Fedotova, I. V.; Kozyrev, A. A.; Yunga, S. L.

The focal mechanisms of seismic events in the Khibiny massive and their interrelation with spent mining operations were investigated. As a result it is detected, that redistri- bution of stresses stipulated by structural features of a rock mass and ore technology, is the basic reason of origin of dynamic rock pressure manifestations. On the basis of the available plan tectonic disturbances of an investigated lease of a massif and anal- ysis of seismic activity, in view of events with the detected focal mechanism, some bands, various on a degree of potential seismic activity are chosen. For each band the calculations of mechanisms of rock bumps with separation of planes of adjustments with engaging of the geologic data are held. As a result of this analysis it is approved, that the basic forerunner of cracking of a separation at a roof fall of the cantilever of hanging wall (on decryption of focal mechanisms) is the reorientation of axes of prin- cipal stresses. And, at conducting coal-face works in a trailing side of ore deposits, at cracking a separation in the cantilever of hanging wall there are seismic events pre- dominantly to a fault type of the focal mechanism. In a massif of soils of the working excavation, located in limits, and under it, most typical focal mechanisms are mainly strike-slip and normal faults. The researches are executed at support of the Russian foundation for basic research, - projects 00-05-64758, 01-05-65340.

Technique to separate lidar signal and sunlight.

PubMed

Sun, Wenbo; Hu, Yongxiang; MacDonnell, David G; Weimer, Carl; Baize, Rosemary R

2016-06-13

Sunlight contamination dominates the backscatter noise in space-based lidar measurements during daytime. The background scattered sunlight is highly variable and dependent upon the surface and atmospheric albedo. The scattered sunlight contribution to noise increases over land and snow surfaces where surface albedos are high and thus overwhelm lidar backscatter from optically thin atmospheric constituents like aerosols and thin clouds. In this work, we developed a novel lidar remote sensing concept that potentially can eliminate sunlight induced noise. The new lidar concept requires: (1) a transmitted laser light that carries orbital angular momentum (OAM); and (2) a photon sieve (PS) diffractive filter that separates scattered sunlight from laser light backscattered from the atmosphere, ocean and solid surfaces. The method is based on numerical modeling of the focusing of Laguerre-Gaussian (LG) laser beam and plane-wave light by a PS. The model results show that after passing through a PS, laser light that carries the OAM is focused on a ring (called "focal ring" here) on the focal plane of the PS filter, very little energy arrives at the center of the focal plane. However, scattered sunlight, as a plane wave without the OAM, focuses at the center of the focal plane and thus can be effectively blocked or ducted out. We also find that the radius of the "focal ring" increases with the increase of azimuthal mode (L) of LG laser light, thus increasing L can more effectively separate the lidar signal away from the sunlight noise.

Acoustic suspension system

NASA Technical Reports Server (NTRS)

Lee, M. C.; Wang, T. G. (Inventor)

1983-01-01

An acoustic levitation system is described, with single acoustic source and a small reflector to stably levitate a small object while the object is processed as by coating or heating it. The system includes a concave acoustic source which has locations on opposite sides of its axis that vibrate towards and away from a focal point to generate a converging acoustic field. A small reflector is located near the focal point, and preferably slightly beyond it, to create an intense acoustic field that stably supports a small object near the reflector. The reflector is located about one-half wavelength from the focal point and is concavely curved to a radius of curvature (L) of about one-half the wavelength, to stably support an object one-quarter wavelength (N) from the reflector.

Infrared Smartt Interferometer As An Alignment Tool For Carbon Dioxide Laser Fusion Systems

NASA Astrophysics Data System (ADS)

Viswanathan, V. K.; Bolen, P. D.

1980-11-01

It is essential to minimize the pointing and focusing errors at the focal plane for many applications involving infrared laser systems. In the case of the LASL CO2 laser fusion systems, with two beams in the Gemini System and eight beams in the Helios System, this is particularly important. The LASL Helios CO2 Laser Fusion System has eight 34-cm diameter beams emerging from the power amplifier and each beam is brought to focus by an off-aperture parabola (nearly 77.3-cm focal length) resulting in a nearly F/2.4 beam at the focal plane. The design tolerance at the focal plane for pointing accuracy is +/- 25 microns and for focusing accuracy is +/- 50 microns for this system. This paper describes an alignment scheme based on the use of the infrared Smartt interferometer' and compares the results obtained using this technique and the autocollimating Hartmann scheme2 in a laboratory setup duplicating the target chamber region of one of the beams of the Helios System. The results using the Smartt interferometer show that pointing accuracy of +/- 12.5 microns and focusing accuracies of ± 15 microns are obtained at the focal plane of the system.

Method for chemically analyzing a solution by acoustic means

DOEpatents

Beller, L.S.

1997-04-22

A method and apparatus are disclosed for determining a type of solution and the concentration of that solution by acoustic means. Generally stated, the method consists of: immersing a sound focusing transducer within a first liquid filled container; locating a separately contained specimen solution at a sound focal point within the first container; locating a sound probe adjacent to the specimen, generating a variable intensity sound signal from the transducer; measuring fundamental and multiple harmonic sound signal amplitudes; and then comparing a plot of a specimen sound response with a known solution sound response, thereby determining the solution type and concentration. 10 figs.

Multispectral Resource Sampler - An experimental satellite sensor for the mid-1980s

NASA Technical Reports Server (NTRS)

Schnetzler, C. C.; Thompson, L. L.

1979-01-01

An experimental pushbroom scan sensor, the Multispectral Resource Sampler (MRS), being developed by NASA for a future earth orbiting flight is presented. This sensor will provide new earth survey capabilities beyond those of current sensor systems, with a ground resolution of 15 m over a swath width of 15 km in four bands. The four arrays are aligned on a common focal surface requiring no beamsplitters, thus causing a spatial separation on the ground which requires computer processing to register the bands. Along track pointing permits stereo coverage at variable base/height ratios and atmospheric correction experiments, while across track pointing will provide repeat coverage, from a Landsat-type orbit, of every 1 to 3 days. The MRS can be used for experiments in crop discrimination and status, rock discrimination, land use classification, and forestry.

The positive impact of simultaneous implementation of the BD FocalPoint GS Imaging System and lean principles on the operation of gynecologic cytology.

PubMed

Wong, Rebecca; Levi, Angelique W; Harigopal, Malini; Schofield, Kevin; Chhieng, David C

2012-02-01

Our cytology laboratory, like many others, is under pressure to improve quality and provide test results faster while decreasing costs. We sought to address these issues by introducing new technology and lean principles. To determine the combined impact of the FocalPoint Guided Screener (GS) Imaging System (BD Diagnostics-TriPath, Burlington, North Carolina) and lean manufacturing principles on the turnaround time (TAT) and productivity of the gynecologic cytology operation. We established a baseline measure of the TAT for Papanicolaou tests. We then compared that to the performance after implementing the FocalPoint GS Imaging System and lean principles. The latter included value-stream mapping, workflow modification, and a first in-first out policy. The mean (SD) TAT for Papanicolaou tests before and after the implementation of FocalPoint GS Imaging System and lean principles was 4.38 (1.28) days and 3.20 (1.32) days, respectively. This represented a 27% improvement in the average TAT, which was statistically significant (P < .001). In addition, the productivity of staff improved 17%, as evidenced by the increase in slides screened from 8.85/h to 10.38/h. The false-negative fraction decreased from 1.4% to 0.9%, representing a 36% improvement. In our laboratory, the implementation of FocalPoint GS Imaging System in conjunction with lean principles resulted in a significant decrease in the average TAT for Papanicolaou tests and a substantial increase in the productivity of cytotechnologists while maintaining the diagnostic quality of gynecologic cytology.

Theory of dispersive microlenses

NASA Technical Reports Server (NTRS)

Herman, B.; Gal, George

1993-01-01

A dispersive microlens is a miniature optical element which simultaneously focuses and disperses light. Arrays of dispersive mircolenses have potential applications in multicolor focal planes. They have a 100 percent optical fill factor and can focus light down to detectors of diffraction spot size, freeing up areas on the focal plane for on-chip analog signal processing. Use of dispersive microlenses allows inband color separation within a pixel and perfect scene registration. A dual-color separation has the potential for temperature discrimination. We discuss the design of dispersive microlenses and present sample results for efficient designs.

Partnering with Families. Focal Point: A National Bulletin on Family Support and Children's Mental Health. Volume 18, Number 1, Summer 2004

ERIC Educational Resources Information Center

Walker, Janet S., Ed.

2004-01-01

The articles in this issue of "Focal Point" focus on the Research and Training Center's current work, which reflects the evolution of expectations for partnering with youth and families. Partnering successfully requires not only a philosophical commitment to the value, but also intentional, specific steps to redesign services and reallocate…

A compact spectrum splitting concentrator for high concentration photovoltaics based on the dispersion of a lens

NASA Astrophysics Data System (ADS)

He, J.; Flowers, C. A.; Yao, Y.; Atwater, H. A.; Rockett, A. A.; Nuzzo, R. G.

2018-06-01

Photovoltaic devices used in conjunction with functional optical elements for light concentration and spectrum splitting are known to be a viable approach for highly efficient photovoltaics. Conventional designs employ discrete optical elements, each with the task of either performing optical concentration or separating the solar spectrum. In the present work, we examine the performance of a compact photovoltaic architecture in which a single lens plays a dual role as both a concentrator and a spectrum splitter, the latter made possible by exploiting its intrinsic dispersion. A four-terminal two-junction InGaP/GaAs device is prepared to validate the concept and illustrates pathways for improvements. A spectral separation in the visible range is demonstrated at the focal point of a plano-convex lens with a geometric concentration ratio of 1104X with respect to the InGaP subcell.

Emerging infectious diseases not covered by routine vaccination in Europe in 2010-2015--the review of WHO and ECDC notifications for the National IHR Focal Point in Poland.

PubMed

Henszel, Łukasz; Janiec, Janusz; Izdebski, Radosław; Radziszewski, Franciszek; Polański, Piotr

2015-01-01

The National IHR Focal Point is a center set up by each Member State of the World Health Organization (WHO) in accordance with the International Health Regulations (2005). The International Health Regulations (IHR) were adopted on 23 May 2005 at the World Health Assembly and entered into force since 15 June 2007 as the legal instrument designed to help protect all countries from uncontrolled international spread of diseases and other urgent public health threats. According to Article 2 of IHR the purpose and scope of these Regulations are to prevent, protect against, control and provide a public health response to the international spread of disease in ways that are commensurate with and restricted to public health risks, and which avoid unnecessary interference with international traffic and trade. Primarily, the scope of IHR is to establish a system of early warning (in accordance with Article 6 and 7) with the functioning in each country National IHR Focal Point which is available at any time to communicate with WHO IHR Contact Points and other entities. The tasks of the National IHR Fo- cal Point in Poland which was appointed by the Minister of Health and runs in the Department of Epidemiology, National Institute of Public Health--National Institute of Hygiene from 1 September 2007 are the notification of events that may constitute a public health emergency of international concern occurring in Poland or abroad and the dissemination of this information to the WHO, other National IHR Focal Points or competent authorities responsible for public health. The task of the National IHR Focal Point in Poland is also the dissemination of WHO and ECDC notifications, including recommendation and risk assessment documents. The aim of this work is the review of WHO and ECDC notifications received by National IHR Focal Point in Poland in the period from 2010 to 2015 which were related to emerging infectious diseases not covered by routine vaccination programs or for which there are no effective vaccines that have occurred in the WHO European Region. The review includes verotoxin-producing Escherichia coli O104: H4 infections, MERS-CoV infections, Ebola virus disease, malaria, dengue fever, West Nile fever, chikungunya and cholera.

A new measurement method of profile tolerance for the LAMOST focal plane

NASA Astrophysics Data System (ADS)

Zhou, Zengxiang; Jin, Yi; Zhai, Chao; Xing, Xiaozheng

2008-07-01

There were a few methods taken in the profile tolerance measurement of the LAMOST Focal Plane Plate. One of the methods was to use CMM (Coordinate Measurement Machine) to measure the points on the small Focal Plane Plate and calculate the points whether or not in the tolerance zone. In this process there are some small shortcomings. The measuring point positions on the Focal Plane Plate are not the actual installation location of the optical fiber positioning system. In order to eliminate these principle errors, a measuring mandrel is inserted into the unit-holes, and the precision for the mandrel with the hole is controlled in the high level. Then measure the center of the precise target ball which is placed on the measuring mandrel by CMM. At last, fit a sphere surface with the measuring center points of the target ball and analyze the profile tolerance of the Focal Plane Plate. This process will be more in line with the actual installation location of the optical fiber positioning system. When use this method to judge the profile tolerance can provide the reference date for maintaining the ultra error unit-holes on the Focal Plane Plate. But when insert the measuring mandrel into the unit hole, there are manufacturing errors in the measuring mandrel, target ball and assembly errors. All these errors will bring the influence in the measurement. In the paper, an impact evaluation assesses the intermediate process with all these errors through experiments. And the experiment results show that there are little influence when use the target ball and the measuring mandrel in the measurement of the profile tolerance. Instead, there are more advantages than many past use of measuring methods.

Television monitor field shifter and an opto-electronic method for obtaining a stereo image of optimal depth resolution and reduced depth distortion on a single screen

NASA Technical Reports Server (NTRS)

Diner, Daniel B. (Inventor)

1989-01-01

A method and apparatus is developed for obtaining a stereo image with reduced depth distortion and optimum depth resolution. Static and dynamic depth distortion and depth resolution tradeoff is provided. Cameras obtaining the images for a stereo view are converged at a convergence point behind the object to be presented in the image, and the collection-surface-to-object distance, the camera separation distance, and the focal lengths of zoom lenses for the cameras are all increased. Doubling the distances cuts the static depth distortion in half while maintaining image size and depth resolution. Dynamic depth distortion is minimized by panning a stereo view-collecting camera system about a circle which passes through the convergence point and the camera's first nodal points. Horizontal field shifting of the television fields on a television monitor brings both the monitor and the stereo views within the viewer's limit of binocular fusion.

Corrections. Focal Point: Research, Policy, and Practice in Children's Mental Health. Volume 20, Number 2, Summer 2006

ERIC Educational Resources Information Center

Walker, Janet S., Ed.

2006-01-01

This issue of "Focal Point" describes the need for, and provides examples of, new strategies for meeting the mental health needs of children and adolescents involved with the juvenile justice system. Articles in this issue discuss the particular need for correction in the way that the juvenile justice system interacts with youth who have mental…

Workforce. Focal Point: Research, Policy, and Practice in Children's Mental Health. Volume 22, Number 1, Winter 2008

ERIC Educational Resources Information Center

Walker, Janet S., Ed.; Gowen, L. Kris, Ed.; Aue, Nicole, Ed.

2008-01-01

This issue of "Focal Point" explores how the increasing emphasis on using evidence-based practices and a "system of care" approach is driving changes in jobs and roles related to children's mental health. Articles in the issue describe how agencies and providers of services and supports have responded to these changes by creating new types of…

Resilience and Recovery. Focal Point: Research, Policy, and Practice in Children's Mental Health. Volume 19, Number 1, Summer 2005

ERIC Educational Resources Information Center

Walker, Janet S., Ed.

2005-01-01

This issue of "Focal Point" explores the concepts of resilience and recovery and what they mean in the context of mental health care for children and adolescents. From the articles, it emerges that the terminology associated with recovery and resilience (particularly the word, recovery, itself) can be confusing and even off-putting to…

Strengthening Social Support. Focal Point: Research, Policy, and Practice in Children's Mental Health. Volume 20, Number 1, Winter 2006

ERIC Educational Resources Information Center

Walker, Janet S., Ed.

2006-01-01

This issue of "Focal Point" explores some of what is known and unknown about strengthening social support. This introduction outlines some of the major concepts and themes in research on social support, and some implications of this research for interventions in children's mental health. This sets the stage for the rest of the issue, which…

Visualization of Surface Flow on a Prolate Spheroid Model Suspended by Magnetic Suspension and Balance System

NASA Astrophysics Data System (ADS)

Ambo, Takumi; Nakamura, Yuki; Ochiai, Taku; Nonomura, Taku; Asai, Keisuke

2017-11-01

In this study, the surface flow on a 6:1 prolate spheroid model was visualized by oil flow method in the magnetic suspension and balance system (MSBS). The MSBS is a support-free system for wind-tunnel test in that a model is levitated by magnetic force. In this experiment, the 0.3-m MSBS was installed in the low-speed wind tunnel. The Reynolds number was 0.5 million and the angle of attack was set 0 and 5 degrees. In addition to free-levitation tests, a thin rod simulating disturbance of a support system was placed on the model surface and the influence of support interference was evaluated. The obtained results indicate that complicated separation patterns are present even at zero angle of attack. At α = 5°, separation pattern becomes more complicated than that at α = 0° and the streamlines form a highly three-dimensional structure. A characteristic pattern of open separation is observed and a focal point is formed at the end of the separation line. In evaluation of the support interference, the separation is delayed in the downstream of the rod, suggesting that the change of separation pattern is caused by the transition of laminar boundary layer behind the rod. These results indicate that one must take particular care to the support interference in studying three-dimensional separation on a prolate spheroid.

Formation of the Light Infantry.

DTIC Science & Technology

1986-03-21

for light infantry force. Using the conversion of the Army’s 7th Infantry Division as the focal point, the critical issues that effected that...7th Infantry Division-as the focal point, the critical issues that effected that conversion are discussed. Personnel issues addressed consider the...Fort Ord one day and leaving for Fort Benning the next were not uncommon. This slow formation also impacted on the effectiveness of the initial

Focal Point Inside the Vacuum Chamber for Solar Thermal Propulsion

NASA Technical Reports Server (NTRS)

1999-01-01

Researchers at the Marshall Space Flight Center (MSFC) have designed, fabricated, and tested the first solar thermal engine, a non-chemical rocket engine that produces lower thrust but has better thrust efficiency than a chemical combustion engine. MSFC turned to solar thermal propulsion in the early 1990s due to its simplicity, safety, low cost, and commonality with other propulsion systems. Solar thermal propulsion works by acquiring and redirecting solar energy to heat a propellant. The 20- by 24-ft heliostat mirror (not shown in this photograph) has dual-axis control that keeps a reflection of the sunlight on an 18-ft diameter concentrator mirror, which then focuses the sunlight to a 4-in focal point inside the vacuum chamber. The focal point has 10 kilowatts of intense solar power. This photograph is a close-up view of a 4-in focal point inside the vacuum chamber at the MSFC Solar Thermal Propulsion Test facility. As part of MSFC's Space Transportation Directorate, the Propulsion Research Center serves as a national resource for research of advanced, revolutionary propulsion technologies. The mission is to move the Nation's capabilities beyond the confines of conventional chemical propulsion into an era of aircraft-like access to Earth orbit, rapid travel throughout the solar system, and exploration of interstellar space.

Persistence of Neighborhood Demographic Influences over Long Phylogenetic Distances May Help Drive Post-Speciation Adaptation in Tropical Forests

PubMed Central

Wills, Christopher; Harms, Kyle E.; Wiegand, Thorsten; Punchi-Manage, Ruwan; Gilbert, Gregory S.; Erickson, David; Kress, W. John; Hubbell, Stephen P.; Gunatilleke, C. V. Savitri; Gunatilleke, I. A. U. Nimal

2016-01-01

Studies of forest dynamics plots (FDPs) have revealed a variety of negative density-dependent (NDD) demographic interactions, especially among conspecific trees. These interactions can affect growth rate, recruitment and mortality, and they play a central role in the maintenance of species diversity in these complex ecosystems. Here we use an equal area annulus (EAA) point-pattern method to comprehensively analyze data from two tropical FDPs, Barro Colorado Island in Panama and Sinharaja in Sri Lanka. We show that these NDD interactions also influence the continued evolutionary diversification of even distantly related tree species in these FDPs. We examine the details of a wide range of these interactions between individual trees and the trees that surround them. All these interactions, and their cumulative effects, are strongest among conspecific focal and surrounding tree species in both FDPs. They diminish in magnitude with increasing phylogenetic distance between heterospecific focal and surrounding trees, but do not disappear or change the pattern of their dependence on size, density, frequency or physical distance even among the most distantly related trees. The phylogenetic persistence of all these effects provides evidence that interactions between tree species that share an ecosystem may continue to promote adaptive divergence even after the species’ gene pools have become separated. Adaptive divergence among taxa would operate in stark contrast to an alternative possibility that has previously been suggested, that distantly related species with dispersal-limited distributions and confronted with unpredictable neighbors will tend to converge on common strategies of resource use. In addition, we have also uncovered a positive density-dependent effect: growth rates of large trees are boosted in the presence of a smaller basal area of surrounding trees. We also show that many of the NDD interactions switch sign rapidly as focal trees grow in size, and that their cumulative effect can strongly influence the distributions and species composition of the trees that surround the focal trees during the focal trees’ lifetimes. PMID:27305092

Focal and Ambient Processing of Built Environments: Intellectual and Atmospheric Experiences of Architecture

PubMed Central

Rooney, Kevin K.; Condia, Robert J.; Loschky, Lester C.

2017-01-01

Neuroscience has well established that human vision divides into the central and peripheral fields of view. Central vision extends from the point of gaze (where we are looking) out to about 5° of visual angle (the width of one’s fist at arm’s length), while peripheral vision is the vast remainder of the visual field. These visual fields project to the parvo and magno ganglion cells, which process distinctly different types of information from the world around us and project that information to the ventral and dorsal visual streams, respectively. Building on the dorsal/ventral stream dichotomy, we can further distinguish between focal processing of central vision, and ambient processing of peripheral vision. Thus, our visual processing of and attention to objects and scenes depends on how and where these stimuli fall on the retina. The built environment is no exception to these dependencies, specifically in terms of how focal object perception and ambient spatial perception create different types of experiences we have with built environments. We argue that these foundational mechanisms of the eye and the visual stream are limiting parameters of architectural experience. We hypothesize that people experience architecture in two basic ways based on these visual limitations; by intellectually assessing architecture consciously through focal object processing and assessing architecture in terms of atmosphere through pre-conscious ambient spatial processing. Furthermore, these separate ways of processing architectural stimuli operate in parallel throughout the visual perceptual system. Thus, a more comprehensive understanding of architecture must take into account that built environments are stimuli that are treated differently by focal and ambient vision, which enable intellectual analysis of architectural experience versus the experience of architectural atmosphere, respectively. We offer this theoretical model to help advance a more precise understanding of the experience of architecture, which can be tested through future experimentation. (298 words) PMID:28360867

Focal and Ambient Processing of Built Environments: Intellectual and Atmospheric Experiences of Architecture.

PubMed

Rooney, Kevin K; Condia, Robert J; Loschky, Lester C

2017-01-01

Neuroscience has well established that human vision divides into the central and peripheral fields of view. Central vision extends from the point of gaze (where we are looking) out to about 5° of visual angle (the width of one's fist at arm's length), while peripheral vision is the vast remainder of the visual field. These visual fields project to the parvo and magno ganglion cells, which process distinctly different types of information from the world around us and project that information to the ventral and dorsal visual streams, respectively. Building on the dorsal/ventral stream dichotomy, we can further distinguish between focal processing of central vision, and ambient processing of peripheral vision. Thus, our visual processing of and attention to objects and scenes depends on how and where these stimuli fall on the retina. The built environment is no exception to these dependencies, specifically in terms of how focal object perception and ambient spatial perception create different types of experiences we have with built environments. We argue that these foundational mechanisms of the eye and the visual stream are limiting parameters of architectural experience. We hypothesize that people experience architecture in two basic ways based on these visual limitations; by intellectually assessing architecture consciously through focal object processing and assessing architecture in terms of atmosphere through pre-conscious ambient spatial processing. Furthermore, these separate ways of processing architectural stimuli operate in parallel throughout the visual perceptual system. Thus, a more comprehensive understanding of architecture must take into account that built environments are stimuli that are treated differently by focal and ambient vision, which enable intellectual analysis of architectural experience versus the experience of architectural atmosphere, respectively. We offer this theoretical model to help advance a more precise understanding of the experience of architecture, which can be tested through future experimentation. (298 words).

Persistence of Neighborhood Demographic Influences over Long Phylogenetic Distances May Help Drive Post-Speciation Adaptation in Tropical Forests.

PubMed

Wills, Christopher; Harms, Kyle E; Wiegand, Thorsten; Punchi-Manage, Ruwan; Gilbert, Gregory S; Erickson, David; Kress, W John; Hubbell, Stephen P; Gunatilleke, C V Savitri; Gunatilleke, I A U Nimal

2016-01-01

Studies of forest dynamics plots (FDPs) have revealed a variety of negative density-dependent (NDD) demographic interactions, especially among conspecific trees. These interactions can affect growth rate, recruitment and mortality, and they play a central role in the maintenance of species diversity in these complex ecosystems. Here we use an equal area annulus (EAA) point-pattern method to comprehensively analyze data from two tropical FDPs, Barro Colorado Island in Panama and Sinharaja in Sri Lanka. We show that these NDD interactions also influence the continued evolutionary diversification of even distantly related tree species in these FDPs. We examine the details of a wide range of these interactions between individual trees and the trees that surround them. All these interactions, and their cumulative effects, are strongest among conspecific focal and surrounding tree species in both FDPs. They diminish in magnitude with increasing phylogenetic distance between heterospecific focal and surrounding trees, but do not disappear or change the pattern of their dependence on size, density, frequency or physical distance even among the most distantly related trees. The phylogenetic persistence of all these effects provides evidence that interactions between tree species that share an ecosystem may continue to promote adaptive divergence even after the species' gene pools have become separated. Adaptive divergence among taxa would operate in stark contrast to an alternative possibility that has previously been suggested, that distantly related species with dispersal-limited distributions and confronted with unpredictable neighbors will tend to converge on common strategies of resource use. In addition, we have also uncovered a positive density-dependent effect: growth rates of large trees are boosted in the presence of a smaller basal area of surrounding trees. We also show that many of the NDD interactions switch sign rapidly as focal trees grow in size, and that their cumulative effect can strongly influence the distributions and species composition of the trees that surround the focal trees during the focal trees' lifetimes.

Bifocal Fresnel Lens Based on the Polarization-Sensitive Metasurface

NASA Astrophysics Data System (ADS)

Markovich, Hen; Filonov, Dmitrii; Shishkin, Ivan; Ginzburg, Pavel

2018-05-01

Thin structured surfaces allow flexible control over propagation of electromagnetic waves. Focusing and polarization state analysis are among functions, required for effective manipulation of radiation. Here a polarization sensitive Fresnel zone plate lens is proposed and experimentally demonstrated for GHz spectral range. Two spatially separated focal spots for orthogonal polarizations are obtained by designing metasurface pattern, made of overlapping tightly packed cross and rod shaped antennas with a strong polarization selectivity. Optimized subwavelength pattern allows multiplexing two different lenses with low polarization crosstalk on the same substrate and provides a control over focal spots of the lens only by changing of the polarization state of the incident wave. More than a wavelength separation between the focal spots was demonstrated for a broad spectral range, covering half a decade in frequency. The proposed concept could be straightforwardly extended for THz and visible spectra, where polarization-sensitive elements utilize localized plasmon resonance phenomenon.

Simulation of the Focal Spot of the Accelerator Bremsstrahlung Radiation

NASA Astrophysics Data System (ADS)

Sorokin, V.; Bespalov, V.

2016-06-01

Testing of thick-walled objects by bremsstrahlung radiation (BR) is primarily performed via high-energy quanta. The testing parameters are specified by the focal spot size of the high-energy bremsstrahlung radiation. In determining the focal spot size, the high- energy BR portion cannot be experimentally separated from the low-energy BR to use high- energy quanta only. The patterns of BR focal spot formation have been investigated via statistical modeling of the radiation transfer in the target material. The distributions of BR quanta emitted by the target for different energies and emission angles under normal distribution of the accelerated electrons bombarding the target have been obtained, and the ratio of the distribution parameters has been determined.

Alignment reference device

DOEpatents

Patton, Gail Y.; Torgerson, Darrel D.

1987-01-01

An alignment reference device provides a collimated laser beam that minimizes angular deviations therein. A laser beam source outputs the beam into a single mode optical fiber. The output end of the optical fiber acts as a source of radiant energy and is positioned at the focal point of a lens system where the focal point is positioned within the lens. The output beam reflects off a mirror back to the lens that produces a collimated beam.

Micro Ring Grating Spectrometer with Adjustable Aperture

NASA Technical Reports Server (NTRS)

Park, Yeonjoon (Inventor); King, Glen C. (Inventor); Elliott, James R. (Inventor); Choi, Sang H. (Inventor)

2012-01-01

A spectrometer includes a micro-ring grating device having coaxially-aligned ring gratings for diffracting incident light onto a target focal point, a detection device for detecting light intensity, one or more actuators, and an adjustable aperture device defining a circular aperture. The aperture circumscribes a target focal point, and directs a light to the detection device. The aperture device is selectively adjustable using the actuators to select a portion of a frequency band for transmission to the detection device. A method of detecting intensity of a selected band of incident light includes directing incident light onto coaxially-aligned ring gratings of a micro-ring grating device, and diffracting the selected band onto a target focal point using the ring gratings. The method includes using an actuator to adjust an aperture device and pass a selected portion of the frequency band to a detection device for measuring the intensity of the selected portion.

Focal Length Controllable Ultrasonic Transducer Using Bimorph-Type Bending Actuator

NASA Astrophysics Data System (ADS)

Chae, Min-Ku; Kim, Moo-Joon; Ha, Kang-Lyeol; Lee, Chai-Bong

2003-05-01

Using a bimorph-type bending actuator, we propose a new method for controlling the focal length of a transducer by electric DC voltage. We designed two focal length controllable ultrasonic transducers with actuators, a line-focus and a point-focus transducer. The polyvinylidene fluoride (PVDF) piezoelectric type polymer film is used for transmitting and receiving of ultrasonic signals. Using the new method, it is confirmed by investigation of the underwater acoustic field that the focal length can be controlled to within 10% of the radius of the transducer curvature.

Design and fabrication of continuous-profile diffractive micro-optical elements as a beam splitter.

PubMed

Feng, Di; Yan, Yingbai; Jin, Guofan; Fan, Shoushan

2004-10-10

An optimization algorithm that combines a rigorous electromagnetic computation model with an effective iterative method is utilized to design diffractive micro-optical elements that exhibit fast convergence and better design quality. The design example is a two-dimensional 1-to-2 beam splitter that can symmetrically generate two focal lines separated by 80 microm at the observation plane with a small angle separation of +/- 16 degrees. Experimental results are presented for an element with continuous profiles fabricated into a monocrystalline silicon substrate that has a width of 160 microm and a focal length of 140 microm at a free-space wavelength of 10.6 microm.

Solid-state image sensor with focal-plane digital photon-counting pixel array

NASA Technical Reports Server (NTRS)

Fossum, Eric R. (Inventor); Pain, Bedabrata (Inventor)

1995-01-01

A photosensitive layer such as a-Si for a UV/visible wavelength band is provided for low light level imaging with at least a separate CMOS amplifier directly connected to each PIN photodetector diode to provide a focal-plane array of NxN pixels, and preferably a separate photon-counting CMOS circuit directly connected to each CMOS amplifier, although one row of counters may be time shared for reading out the photon flux rate of each diode in the array, together with a buffer memory for storing all rows of the NxN image frame before transfer to suitable storage. All CMOS circuitry is preferably fabricated in the same silicon layer as the PIN photodetector diode for a monolithic structure, but when the wavelength band of interest requires photosensitive material different from silicon, the focal-plane array may be fabricated separately on a different semiconductor layer bump-bonded or otherwise bonded for a virtually monolithic structure with one free terminal of each diode directly connected to the input terminal of its CMOS amplifier and digital counter for integration of the photon flux rate at each photodetector of the array.

Evaluation and Validation (E&V) Team Public Report. Volume 2.

DTIC Science & Technology

1985-11-30

Byron, Countess of Lovelace. The Countess was an associate of Charles Babbage and is presumed to be the world’s first programmer (Barnes, 1982:2...by DDT&E, STARS, and AJPO personnel, as appropriate. 4.20.9 Focal Point The DDT&E and STARS focal points, respectively, are indicated below Charles K...Technology For Adaptable, Reliable Systems Major Charles W. Lillie from Headquarters Air Force Systems Command gave a presentation concerning Software For

The project of the mass separator of atomic nuclei produced in heavy ion induced reactions

NASA Astrophysics Data System (ADS)

Oganessian, Yu. Ts.; Shchepunov, V. A.; Dmitriev, S. N.; Itkis, M. G.; Gulbekyan, G. G.; Khabarov, M. V.; Bekhterev, V. V.; Bogomolov, S. L.; Efremov, A. A.; Pashenko, S. V.; Stepantsov, S. V.; Yeremin, A. V.; Yavor, M. I.; Kalimov, A. G.

2003-05-01

A new separator and mass analyzer, named MASHA (mass analyzer of super heavy atoms), has been designed at the Flerov Laboratory JINR Dubna to separate and measure masses of nuclei and molecules with precision better than 10 -3. The set up can work in the wide mass range from A≈20 to A≈500, its mass acceptance is as large as ±2.8%. In particular, it allows unambiguous mass identification of super heavy nuclei with a resolution better than 1 amu at the level of 300 amu. Synthesized in nuclear reactions nuclides are emitted from an ECR ion source at energy E=40 kV and charge state Q=+1. Then they pass the following steps of separation and analysis: the first section of rough separation, the second section of separation and mass analysis and the final section of separation with a 90° electrostatic deflector. In the focal plane of the device, a focal plane detector determines positions (masses) of studied nuclei. Ion optics of the analyzer, optimized up to the second order, is considered. Description of its elements and subsystems is given.

Spatial and temporal observation of phase-shift nano-emulsions assisted cavitation and ablation during focused ultrasound exposure.

PubMed

Qiao, Yangzi; Zong, Yujin; Yin, Hui; Chang, Nan; Li, Zhaopeng; Wan, Mingxi

2014-09-01

Phase-shift nano-emulsions (PSNEs) with a small initial diameter in nanoscale have the potential to leak out of the blood vessels and to accumulate at the target point of tissue. At desired location, PSNEs can undergo acoustic droplet vaporization (ADV) process, change into gas bubbles and enhance focused ultrasound efficiency. The threshold of droplet vaporization and influence of acoustic parameters have always been research hotspots in order to spatially control the potential of bioeffects and optimize experimental conditions. However, when the pressure is much higher than PSNEs' vaporization threshold, there were little reports on their cavitation and thermal effects. In this study, PSNEs induced cavitation and ablation effects during pulsed high-intensity focused ultrasound (HIFU) exposure were investigated, including the spatial and temporal information and the influence of acoustic parameters. Two kinds of tissue-mimicking phantoms with uniform PSNEs were prepared because of their optical transparency. The Sonoluminescence (SL) method was employed to visualize the cavitation activities. And the ablation process was observed as the heat deposition could produce white lesion. Precisely controlled HIFU cavitation and ablation can be realized at a relatively low input power. But when the input power was high, PSNEs can accelerate cavitation and ablation in pre-focal region. The cavitation happened layer by layer advancing the transducer. While the lesion appeared to be separated into two parts, one in pre-focal region stemmed from one point and grew quickly, the other in focal region grew much more slowly. The influence of duty cycle has also been examined. Longer pulse off time would cause heat transfer to the surrounding media, and generate smaller lesion. On the other hand, this would give outer layer bubbles enough time to dissolve, and inner bubbles can undergo violent collapse and emit bright light. Copyright © 2014 Elsevier B.V. All rights reserved.

Combining Accuracy and Efficiency: An Incremental Focal-Point Method Based on Pair Natural Orbitals.

PubMed

Fiedler, Benjamin; Schmitz, Gunnar; Hättig, Christof; Friedrich, Joachim

2017-12-12

In this work, we present a new pair natural orbitals (PNO)-based incremental scheme to calculate CCSD(T) and CCSD(T0) reaction, interaction, and binding energies. We perform an extensive analysis, which shows small incremental errors similar to previous non-PNO calculations. Furthermore, slight PNO errors are obtained by using T PNO = T TNO with appropriate values of 10 -7 to 10 -8 for reactions and 10 -8 for interaction or binding energies. The combination with the efficient MP2 focal-point approach yields chemical accuracy relative to the complete basis-set (CBS) limit. In this method, small basis sets (cc-pVDZ, def2-TZVP) for the CCSD(T) part are sufficient in case of reactions or interactions, while some larger ones (e.g., (aug)-cc-pVTZ) are necessary for molecular clusters. For these larger basis sets, we show the very high efficiency of our scheme. We obtain not only tremendous decreases of the wall times (i.e., factors >10 2 ) due to the parallelization of the increment calculations as well as of the total times due to the application of PNOs (i.e., compared to the normal incremental scheme) but also smaller total times with respect to the standard PNO method. That way, our new method features a perfect applicability by combining an excellent accuracy with a very high efficiency as well as the accessibility to larger systems due to the separation of the full computation into several small increments.

High precise measurement of tiny angle dimensional holes for the unit-holes of the LAMOST Focal Plane Plate

NASA Astrophysics Data System (ADS)

Zhou, Zengxiang; Jin, Yi; Zhai, Chao; Xing, Xiaozheng

2008-07-01

In the LAMOST project, the unit-holes on the Focal Plane Plate are the final installation location of the optical fiber positioning system. Theirs precision will influence the observation efficiency of the LAMOST. For the unique requirements, the unit-holes on the Focal Plane Plate are composed by a series of tiny angle dimensional holes which dimensional angle are between 16' to 2.5°. According to these requirements, the measurement of the tiny angle dimensional holes for the unit-holes needs to less than 3'. And all the unit-holes point to the virtual sphere center of the Focal Plane Plate. To that end, the angle departure of the unit-holes axis is changed to the distance from the virtual sphere center of Focal Plane Plate to the unit-holes axis. That is the better way to evaluate the technical requirements of the dimensional angle errors. In the measuring process, common measuring methods do not fit for the tiny angle dimensional hole by CMM(coordinate measurement machine). An extraordinary way to solve this problem is to insert a measuring stick into a unit-hole, with a target ball on the stick. Then measure the low point of the ball center and pull out the stick for the high station of center. Finally, calculate the two points for the unit-hole axis to get the angle departure. But on the other hand, use this methods will bring extra errors for the measuring stick and the target ball. For better analysis this question, a series experiments are mentioned in this paper, which testify that the influence of the measure implement is little. With increasing the distance between the low point and the high point position in the measuring process should enhance the accuracy of dimensional angle measurement.

Focal shift and the axial optical coordinate for high-aperture systems of finite Fresnel number.

PubMed

Sheppard, Colin J R; Török, Peter

2003-11-01

Analytic expressions are given for the on-axis intensity predicted by the Rayleigh-Sommerfeld and Kirchhoff diffraction integrals for a scalar optical system of high numerical aperture and finite value of Fresnel number. A definition of the axial optical coordinate is introduced that is valid for finite values of Fresnel number, for high-aperture systems, and for observation points distant from the focus. The focal shift effect is reexamined. For the case when the focal shift is small, explicit expressions are given for the focal shift and the axial peak in intensity.

Generation of a focused hollow beam by an 2π-phase plate and its application in atom or molecule optics

NASA Astrophysics Data System (ADS)

Xia, Yong; Yin, Jianping

2005-03-01

We propose a new scheme to generate a focusing hollow beam (FHB) by use of an azimuthally distributed 2π-phase plate and a convergent thin lens. From the Fresnel diffraction theory, we calculate the intensity distributions of the FHB in free propagation space and study the relationship between the waist w0 of the incident Gaussian beam (or the focal length f of the lens) and the dark spot size (or the beam radius) at the focal point and the relationship between the maximum radial intensity of the FHB and the dark spot size (or the beam radius) at the focal point, respectively. Our study shows that the FHB can be used to cool and trap neutral atoms by intensity-gradient-induced Sisyphus cooling due to an extremely high intensity gradient of the FHB itself near the focal point, or to guide and focus a cold molecular beam. We also calculate the optical potential of the blue-detuned FHB for 85Rb atoms and find that in the focal plane, the smaller the dark spot size of the FHB is, the higher the optical potential is, and the greater the corresponding optimal detuning δ is; these qualities are beneficial to an atomic lens not only because it is profitable to obtain an atomic lens with a higher resolution, but also because it is helpful to reduce the spontaneous photon-scattering effect of atoms in the FHB.

Micro-Fresnel Zone Plate Optical Devices Using Densely Accumulated Ray Points

NASA Technical Reports Server (NTRS)

Choi, Sang H. (Inventor); Park, Yeonjoon (Inventor); King, Glen C. (Inventor); Elliott, James R. (Inventor)

2011-01-01

An embodiment generally relates to an optical device suitable for use with an optical medium for the storage and retrieval of data. The optical device includes an illumination means for providing a beam of optical radiation of wavelength .lamda. and an optical path that the beam of optical radiation follows. The optical device also includes a diffractive optical element defined by a plurality of annular sections. The plurality of annular sections having a first material alternately disposed with a plurality of annular sections comprising a second material. The diffractive optical element generates a plurality of focal points and densely accumulated ray points with phase contrast phenomena and the optical medium is positioned at a selected focal point or ray point of the diffractive optical element.

Studies on design of 351  nm focal plane diagnostic system prototype and focusing characteristic of SGII-upgraded facility at half achievable energy performance.

PubMed

Liu, Chong; Ji, Lailin; Yang, Lin; Zhao, Dongfeng; Zhang, Yanfeng; Liu, Dong; Zhu, Baoqiang; Lin, Zunqi

2016-04-01

In order to obtain the intensity distribution of a 351 nm focal spot and smoothing by spectral dispersion (SSD) focal plane profile of a SGII-upgraded facility, a type of off-axis imaging system with three spherical mirrors, suitable for a finite distance source point to be imaged near the diffraction limit has been designed. The quality factor of the image system is 1.6 times of the diffraction limit tested by a 1053 nm point source. Because of the absence of a 351 nm point source, we can use a Collins diffraction imaging integral with respect to λ=351  nm, corresponding to a quality factor that is 3.8 times the diffraction limit at 351 nm. The calibration results show that at least the range of ±10  mrad of view field angle and ±50  mm along the axial direction around the optimum object distance can be satisfied with near diffraction limited image that is consistent with the design value. Using this image system, the No. 2 beam of the SGII-upgraded facility has been tested. The test result of the focal spot of final optics assembly (FOA) at 351 nm indicates that about 80% of energy is encompassed in 14.1 times the diffraction limit, while the output energy of the No. 2 beam is 908 J at 1053 nm. According to convolution theorem, the true value of a 351 nm focal spot of FOA is about 12 times the diffraction limit because of the influence of the quality factor. Further experimental studies indicate that the RMS value along the smoothing direction is less than 15.98% in the SSD spot test experiment. Computer simulations show that the quality factor of the image system used in the experiment has almost no effect on the SSD focal spot test. The image system can remarkably distort the SSD focal spot distribution under the circumstance of the quality factor 15 times worse than the diffraction limit. The distorted image shows a steep slope in the contour of the SSD focal spot along the smoothing direction that otherwise has a relatively flat top region around the focal spot center.

Spatial filters for high average power lasers

DOEpatents

Erlandson, Alvin C

2012-11-27

A spatial filter includes a first filter element and a second filter element overlapping with the first filter element. The first filter element includes a first pair of cylindrical lenses separated by a first distance. Each of the first pair of cylindrical lenses has a first focal length. The first filter element also includes a first slit filter positioned between the first pair of cylindrical lenses. The second filter element includes a second pair of cylindrical lenses separated by a second distance. Each of the second pair of cylindrical lenses has a second focal length. The second filter element also includes a second slit filter positioned between the second pair of cylindrical lenses.

Spatial filters for high power lasers

DOEpatents

Erlandson, Alvin Charles; Bayramian, Andrew James

2014-12-02

A spatial filter includes a first filter element and a second filter element overlapping with the first filter element. The first filter element includes a first pair of cylindrical lenses separated by a first distance. Each of the first pair of cylindrical lenses has a first focal length. The first filter element also includes a first longitudinal slit filter positioned between the first pair of cylindrical lenses. The second filter element includes a second pair of cylindrical lenses separated by a second distance. Each of the second pair of cylindrical lenses has a second focal length. The second filter element also includes a second longitudinal slit filter positioned between the second pair of cylindrical lenses.

Point spread function and depth-invariant focal sweep point spread function for plenoptic camera 2.0.

PubMed

Jin, Xin; Liu, Li; Chen, Yanqin; Dai, Qionghai

2017-05-01

This paper derives a mathematical point spread function (PSF) and a depth-invariant focal sweep point spread function (FSPSF) for plenoptic camera 2.0. Derivation of PSF is based on the Fresnel diffraction equation and image formation analysis of a self-built imaging system which is divided into two sub-systems to reflect the relay imaging properties of plenoptic camera 2.0. The variations in PSF, which are caused by changes of object's depth and sensor position variation, are analyzed. A mathematical model of FSPSF is further derived, which is verified to be depth-invariant. Experiments on the real imaging systems demonstrate the consistency between the proposed PSF and the actual imaging results.

Independent component analysis separates spikes of different origin in the EEG.

PubMed

Urrestarazu, Elena; Iriarte, Jorge; Artieda, Julio; Alegre, Manuel; Valencia, Miguel; Viteri, César

2006-02-01

Independent component analysis (ICA) is a novel system that finds independent sources in recorded signals. Its usefulness in separating epileptiform activity of different origin has not been determined. The goal of this study was to demonstrate that ICA is useful for separating different spikes using samples of EEG of patients with focal epilepsy. Digital EEG samples from four patients with focal epilepsy were included. The patients had temporal (n = 2), centrotemporal (n = 1) or frontal spikes (n = 1). Twenty-six samples with two (or more) spikes from two different patients were created. The selection of the two spikes for each mixed EEG was performed randomly, trying to have all the different combinations and rejecting the mixture of two spikes from the same patient. Two different examiners studied the EEGs using ICA with JADE paradigm in Matlab platform, trying to separate and to identify the spikes. They agreed in the correct separation of the spikes in 24 of the 26 samples, classifying the spikes as frontal, temporal or centrotemporal, left or right sided. The demonstration of the possibility of detecting different artificially mixed spikes confirms that ICA may be useful in separating spikes or other elements in real EEGs.

Focal Points, Endogenous Processes, and Exogenous Shocks in the Autism Epidemic

PubMed Central

Liu, Kayuet; Bearman, Peter S.

2014-01-01

Autism prevalence has increased rapidly in the United States during the past two decades. We have previously shown that the diffusion of information about autism through spatially proximate social relations has contributed significantly to the epidemic. This study expands on this finding by identifying the focal points for interaction that drive the proximity effect on subsequent diagnoses. We then consider how diffusion dynamics through interaction at critical focal points, in tandem with exogenous shocks, could have shaped the spatial dynamics of autism in California. We achieve these goals through an empirically calibrated simulation model of the whole population of 3- to 9-year-olds in California. We show that in the absence of interaction at these foci—principally malls and schools—we would not observe an autism epidemic. We also explore the idea that epigenetic changes affecting one generation in the distal past could shape the precise spatial patterns we observe among the next generation. PMID:26166907

The Strong Effects Of On-Axis Focal Shift And Its Nonlinear Variation In Ultrasound Beams Radiated By Low Fresnel Number Transducers

NASA Astrophysics Data System (ADS)

Makov, Y. N.; Espinosa, V.; Sánchez-Morcillo, V. J.; Ramis, J.; Cruañes, J.; Camarena, F.

2006-05-01

On the basis of theoretical concepts, an accurate and complete experimental and numerical examination of the on-axis distribution and the corresponding temporal profiles for low-Fresnel-number focused ultrasound beams under increasing transducer input voltage has been performed. For a real focusing transducer with sufficiently small Fresnel number, a strong initial (linear) shift of the main on-axis pressure maximum from geometrical focal point towards the transducer, and its following displacement towards the focal point and backward motion as the driving transducer voltage increase until highly nonlinear regimes were fixed. The simultaneous monitoring of the temporal waveform modifications determines the real roles and interplay between different nonlinear effects (refraction and attenuation) in the observed dynamics of on-axis pressure maximum. The experimental results are in good agreement with numerical solutions of KZK equation, confirming that the observed dynamic shift of the maximum pressure point is related only to the interplay between diffraction, dissipation and nonlinearity of the acoustic wave.

Design of compact electromagnetic impulse radiating antenna for melanoma treatment.

PubMed

Arockiasamy, Petrishia; Mohan, Sasikala

2016-01-01

Cancer therapy is one of the several new applications which use nanosecond and subnanosecond high voltage pulses. New treatment based on electromagnetic (EM) fields have been developed as non-surgical and minimally invasive treatments of tumors. In particular, subnanosecond pulses can introduce important non-thermal changes in cell biology, especially the permeabilization of the cell membrane. The motivation behind this work is to launch intense subnanosecond pulses to the target (tumors) non-invasively. This works focuses on the design of a compact intense pulsed EM radiating antenna. In tense EM waves radiated at the first focal point of the Prolate Spheroidal Reflector (PSR) are focused at the second focal point where the target (tumor) is present. Two antennas with PSR but fed with different compact wave radiator are designed to focus pulsed field at the second focal point. The PSR with modified bicone antenna feed and PSR with elliptically tapered horn antenna feed are designed. The design parameters and radiation performance are discussed.

Green's function and image system for the Laplace operator in the prolate spheroidal geometry

NASA Astrophysics Data System (ADS)

Xue, Changfeng; Deng, Shaozhong

2017-01-01

In the present paper, electrostatic image theory is studied for Green's function for the Laplace operator in the case where the fundamental domain is either the exterior or the interior of a prolate spheroid. In either case, an image system is developed to consist of a point image inside the complement of the fundamental domain and an additional symmetric continuous surface image over a confocal prolate spheroid outside the fundamental domain, although the process of calculating such an image system is easier for the exterior than for the interior Green's function. The total charge of the surface image is zero and its centroid is at the origin of the prolate spheroid. In addition, if the source is on the focal axis outside the prolate spheroid, then the image system of the exterior Green's function consists of a point image on the focal axis and a line image on the line segment between the two focal points.

A Sandia weapon review bulletin : defense programs, Autumn 1992.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-09-01

Topics in this issue: (1) Focal Point and STEP. Sandia National Laboratories has always focused its advanced weapon development not only on future weapon needs, but also on the engineering and manufacturing sciences needed to meet them. Both areas are changing dramatically. As the nation dismantles many of its warheads, it becomes essential that those that remain are increasingly reliable, secure, capable, and safe. And as development resources diminish, it becomes vital that they are applied to the most critical technologies in a disciplined manner. The mission of the Focal Point program and the Stockpile Transition Enabling Program (STEP) ismore » to develop processes for meeting these challenges. Focal Point offers a decision-making process for allocating Sandia's resources to meets its defense programs strategic goals. (2) Defense Programs news in brief. (3) Dismantling the nuclear stockpile. (4) W88/MK5: Arming, Fuzing, and Firing system meets all requirements and goals. (5) The Common Radar Fuze. (6) Insertable-explosive arming of firing sets. (7) Preparing for fewer underground tests.« less

Real-time adaptive methods for treatment of mobile organs by MRI-controlled high-intensity focused ultrasound.

PubMed

de Senneville, Baudouin Denis; Mougenot, Charles; Moonen, Chrit T W

2007-02-01

Focused ultrasound (US) is a unique and noninvasive technique for local deposition of thermal energy deep inside the body. MRI guidance offers the additional benefits of excellent target visualization and continuous temperature mapping. However, treating a moving target poses severe problems because 1) motion-related thermometry artifacts must be corrected, 2) the US focal point must be relocated according to the target displacement. In this paper a complete MRI-compatible, high-intensity focused US (HIFU) system is described together with adaptive methods that allow continuous MR thermometry and therapeutic US with real-time tracking of a moving target, online motion correction of the thermometry maps, and regional temperature control based on the proportional, integral, and derivative method. The hardware is based on a 256-element phased-array transducer with rapid electronic displacement of the focal point. The exact location of the target during US firing is anticipated using automatic analysis of periodic motions. The methods were tested with moving phantoms undergoing either rigid body or elastic periodical motions. The results show accurate tracking of the focal point. Focal and regional temperature control is demonstrated with a performance similar to that obtained with stationary phantoms. Copyright (c) 2007 Wiley-Liss, Inc.

In-Situ Real-Time Focus Detection during Laser Processing Using Double-Hole Masks and Advanced Image Sensor Software

PubMed Central

Hoang, Phuong Le; Ahn, Sanghoon; Kim, Jeng-o; Kang, Heeshin; Noh, Jiwhan

2017-01-01

In modern high-intensity ultrafast laser processing, detecting the focal position of the working laser beam, at which the intensity is the highest and the beam diameter is the lowest, and immediately locating the target sample at that point are challenging tasks. A system that allows in-situ real-time focus determination and fabrication using a high-power laser has been in high demand among both engineers and scientists. Conventional techniques require the complicated mathematical theory of wave optics, employing interference as well as diffraction phenomena to detect the focal position; however, these methods are ineffective and expensive for industrial application. Moreover, these techniques could not perform detection and fabrication simultaneously. In this paper, we propose an optical design capable of detecting the focal point and fabricating complex patterns on a planar sample surface simultaneously. In-situ real-time focus detection is performed using a bandpass filter, which only allows for the detection of laser transmission. The technique enables rapid, non-destructive, and precise detection of the focal point. Furthermore, it is sufficiently simple for application in both science and industry for mass production, and it is expected to contribute to the next generation of laser equipment, which can be used to fabricate micro-patterns with high complexity. PMID:28671566

Implementation of focal zooming on the Nike KrF laser

NASA Astrophysics Data System (ADS)

Kehne, D. M.; Karasik, M.; Aglitsky, Y.; Smyth, Z.; Terrell, S.; Weaver, J. L.; Chan, Y.; Lehmberg, R. H.; Obenschain, S. P.

2013-01-01

In direct drive inertial confinement laser fusion, a pellet containing D-T fuel is imploded by ablation arising from absorption of laser energy at its outer surface. For optimal coupling, the focal spot of the laser would continuously decrease to match the reduction in the pellet's diameter, thereby minimizing wasted energy. A krypton-fluoride laser (λ = 248 nm) that incorporates beam smoothing by induced spatial incoherence has the ability to produce a high quality focal profile whose diameter varies with time, a property known as focal zooming. A two-stage focal zoom has been demonstrated on the Nike laser at the Naval Research Laboratory. In the experiment, a 4.4 ns laser pulse was created in which the on-target focal spot diameter was 1.3 mm (full width at half maximum) for the first 2.4 ns and 0.28 mm for the final 2 ns. These two diameters appear in time-integrated focal plane equivalent images taken at several locations in the amplification chain. Eight of the zoomed output beams were overlapped on a 60 μm thick planar polystyrene target. Time resolved images of self-emission from the rear of the target show the separate shocks launched by the two corresponding laser focal diameters.

Implementation of focal zooming on the Nike KrF laser.

PubMed

Kehne, D M; Karasik, M; Aglitsky, Y; Smyth, Z; Terrell, S; Weaver, J L; Chan, Y; Lehmberg, R H; Obenschain, S P

2013-01-01

In direct drive inertial confinement laser fusion, a pellet containing D-T fuel is imploded by ablation arising from absorption of laser energy at its outer surface. For optimal coupling, the focal spot of the laser would continuously decrease to match the reduction in the pellet's diameter, thereby minimizing wasted energy. A krypton-fluoride laser (λ = 248 nm) that incorporates beam smoothing by induced spatial incoherence has the ability to produce a high quality focal profile whose diameter varies with time, a property known as focal zooming. A two-stage focal zoom has been demonstrated on the Nike laser at the Naval Research Laboratory. In the experiment, a 4.4 ns laser pulse was created in which the on-target focal spot diameter was 1.3 mm (full width at half maximum) for the first 2.4 ns and 0.28 mm for the final 2 ns. These two diameters appear in time-integrated focal plane equivalent images taken at several locations in the amplification chain. Eight of the zoomed output beams were overlapped on a 60 μm thick planar polystyrene target. Time resolved images of self-emission from the rear of the target show the separate shocks launched by the two corresponding laser focal diameters.

Positive focal shift of gallium nitride high contrast grating focusing reflectors

NASA Astrophysics Data System (ADS)

He, Shumin; Wang, Zhenhai; Liu, Qifa

2016-09-01

We design a type of metasurfaces capable of serving as a visible-light focusing reflector based on gallium nitride (GaN) high contrast gratings (HCGs). The wavefront of the reflected light is precisely manipulated by spatial variation of the grating periods along the subwavelength ridge array to achieve light focusing. Different from conventional negative focal shift effect, a positive focal shift is observed in such focusing reflectors. Detailed investigations of the influence of device size on the focusing performance, especially the focal length, are preformed via a finite element method . The results show that all performance parameters are greatly affected by the reflector size. A more concentrated focal point, or a better focusing capability, can be achieved by larger size. With increasing reflector size, the achieved focal length decreases and gradually approaches to the design, thus the corresponding positive focal shift decreases. Our results are helpful for understanding the visible-light control of the planar HCG-based focusing reflectors.

Site Characterization and Analysis Penetrometer System (SCAPS) Heavy Metal Sensors

DTIC Science & Technology

2003-04-01

gigawatts per square centimeter (GW/cm2). Within the small volume about the focal point, rapid heating, vaporization, and ionization of a small amount of the...2001). Briefly, the light emitted from the fiber in the probe is collimated, turned by a quartz prism, and focused by a short- focal -length quartz 5...are decoupled using the configuration shown in Figure 1. The excitation beam is focused by a 25-cm focal length lens through a 2-inch aluminum mirror

Methods and Devices for Space Optical Communications Using Laser Beams

NASA Technical Reports Server (NTRS)

Goorjian, Peter M. (Inventor)

2018-01-01

Light is used to communicate between objects separated by a large distance. Light beams are received in a telescopic lens assembly positioned in front of a cat's-eye lens. The light can thereby be received at various angles to be output by the cat's-eye lens to a focal plane of the cat's-eye lens, the position of the light beams upon the focal plane corresponding to the angle of the beam received. Lasers and photodetectors are distributed along this focal plane. A processor receives signals from the photodetectors, and selectively signal lasers positioned proximate the photodetectors detecting light, in order to transmit light encoding data through the cat's-eye lens and also through a telescopic lens back in the direction of the received light beams, which direction corresponds to a location upon the focal plane of the transmitting lasers.

Using avian focal species to inform rangeland management in California oak woodland

Treesearch

Alicia D. Young; Breanna Owens; Melissa Odell; Corey Shake; Wendell Gilgert; Geoffrey R. Geupel

2015-01-01

Biological knowledge about bird focal species may be used to inform planning, habitat management, and restoration efforts, with the assumption that the implementation of these species-based recommendations will maintain and enhance healthy functioning habitats and the ecosystems services they provide. Point Blue Conservation Science in collaboration with the Natural...

Patients with schizophrenia do not preserve automatic grouping when mentally re-grouping figures: shedding light on an ignored difficulty.

PubMed

Giersch, Anne; van Assche, Mitsouko; Capa, Rémi L; Marrer, Corinne; Gounot, Daniel

2012-01-01

Looking at a pair of objects is easy when automatic grouping mechanisms bind these objects together, but visual exploration can also be more flexible. It is possible to mentally "re-group" two objects that are not only separate but belong to different pairs of objects. "Re-grouping" is in conflict with automatic grouping, since it entails a separation of each item from the set it belongs to. This ability appears to be impaired in patients with schizophrenia. Here we check if this impairment is selective, which would suggest a dissociation between grouping and "re-grouping," or if it impacts on usual, automatic grouping, which would call for a better understanding of the interactions between automatic grouping and "re-grouping." Sixteen outpatients with schizophrenia and healthy controls had to identify two identical and contiguous target figures within a display of circles and squares alternating around a fixation point. Eye-tracking was used to check central fixation. The target pair could be located in the same or separate hemifields. Identical figures were grouped by a connector (grouped automatically) or not (to be re-grouped). Attention modulation of automatic grouping was tested by manipulating the proportion of connected and unconnected targets, thus prompting subjects to focalize on either connected or unconnected pairs. Both groups were sensitive to automatic grouping in most conditions, but patients were unusually slowed down for connected targets while focalizing on unconnected pairs. In addition, this unusual effect occurred only when targets were presented within the same hemifield. Patients and controls differed on this asymmetry between within- and across-hemifield presentation, suggesting that patients with schizophrenia do not re-group figures in the same way as controls do. We discuss possible implications on how "re-grouping" ties in with ongoing, automatic perception in healthy volunteers.

Patients with Schizophrenia Do Not Preserve Automatic Grouping When Mentally Re-Grouping Figures: Shedding Light on an Ignored Difficulty

PubMed Central

Giersch, Anne; van Assche, Mitsouko; Capa, Rémi L.; Marrer, Corinne; Gounot, Daniel

2012-01-01

Looking at a pair of objects is easy when automatic grouping mechanisms bind these objects together, but visual exploration can also be more flexible. It is possible to mentally “re-group” two objects that are not only separate but belong to different pairs of objects. “Re-grouping” is in conflict with automatic grouping, since it entails a separation of each item from the set it belongs to. This ability appears to be impaired in patients with schizophrenia. Here we check if this impairment is selective, which would suggest a dissociation between grouping and “re-grouping,” or if it impacts on usual, automatic grouping, which would call for a better understanding of the interactions between automatic grouping and “re-grouping.” Sixteen outpatients with schizophrenia and healthy controls had to identify two identical and contiguous target figures within a display of circles and squares alternating around a fixation point. Eye-tracking was used to check central fixation. The target pair could be located in the same or separate hemifields. Identical figures were grouped by a connector (grouped automatically) or not (to be re-grouped). Attention modulation of automatic grouping was tested by manipulating the proportion of connected and unconnected targets, thus prompting subjects to focalize on either connected or unconnected pairs. Both groups were sensitive to automatic grouping in most conditions, but patients were unusually slowed down for connected targets while focalizing on unconnected pairs. In addition, this unusual effect occurred only when targets were presented within the same hemifield. Patients and controls differed on this asymmetry between within- and across-hemifield presentation, suggesting that patients with schizophrenia do not re-group figures in the same way as controls do. We discuss possible implications on how “re-grouping” ties in with ongoing, automatic perception in healthy volunteers. PMID:22912621

Thermal Effects on Camera Focal Length in Messenger Star Calibration and Orbital Imaging

NASA Astrophysics Data System (ADS)

Burmeister, S.; Elgner, S.; Preusker, F.; Stark, A.; Oberst, J.

2018-04-01

We analyse images taken by the MErcury Surface, Space ENviorment, GEochemistry, and Ranging (MESSENGER) spacecraft for the camera's thermal response in the harsh thermal environment near Mercury. Specifically, we study thermally induced variations in focal length of the Mercury Dual Imaging System (MDIS). Within the several hundreds of images of star fields, the Wide Angle Camera (WAC) typically captures up to 250 stars in one frame of the panchromatic channel. We measure star positions and relate these to the known star coordinates taken from the Tycho-2 catalogue. We solve for camera pointing, the focal length parameter and two non-symmetrical distortion parameters for each image. Using data from the temperature sensors on the camera focal plane we model a linear focal length function in the form of f(T) = A0 + A1 T. Next, we use images from MESSENGER's orbital mapping mission. We deal with large image blocks, typically used for the production of a high-resolution digital terrain models (DTM). We analyzed images from the combined quadrangles H03 and H07, a selected region, covered by approx. 10,600 images, in which we identified about 83,900 tiepoints. Using bundle block adjustments, we solved for the unknown coordinates of the control points, the pointing of the camera - as well as the camera's focal length. We then fit the above linear function with respect to the focal plane temperature. As a result, we find a complex response of the camera to thermal conditions of the spacecraft. To first order, we see a linear increase by approx. 0.0107 mm per degree temperature for the Narrow-Angle Camera (NAC). This is in agreement with the observed thermal response seen in images of the panchromatic channel of the WAC. Unfortunately, further comparisons of results from the two methods, both of which use different portions of the available image data, are limited. If leaving uncorrected, these effects may pose significant difficulties in the photogrammetric analysis, specifically these may be responsible for erroneous longwavelength trends in topographic models.

Image-guided Navigation of Single-element Focused Ultrasound Transducer

PubMed Central

Kim, Hyungmin; Chiu, Alan; Park, Shinsuk; Yoo, Seung-Schik

2014-01-01

The spatial specificity and controllability of focused ultrasound (FUS), in addition to its ability to modify the excitability of neural tissue, allows for the selective and reversible neuromodulation of the brain function, with great potential in neurotherapeutics. Intra-operative magnetic resonance imaging (MRI) guidance (in short, MRg) has limitations due to its complicated examination logistics, such as fixation through skull screws to mount the stereotactic frame, simultaneous sonication in the MRI environment, and restrictions in choosing MR-compatible materials. In order to overcome these limitations, an image-guidance system based on optical tracking and pre-operative imaging data is developed, separating the imaging acquisition for guidance and sonication procedure for treatment. Techniques to define the local coordinates of the focal point of sonication are presented. First, mechanical calibration detects the concentric rotational motion of a rigid-body optical tracker, attached to a straight rod mimicking the sonication path, pivoted at the virtual FUS focus. The spatial error presented in the mechanical calibration was compensated further by MRI-based calibration, which estimates the spatial offset between the navigated focal point and the ground-truth location of the sonication focus obtained from a temperature-sensitive MR sequence. MRI-based calibration offered a significant decrease in spatial errors (1.9±0.8 mm; 57% reduction) compared to the mechanical calibration method alone (4.4±0.9 mm). Using the presented method, pulse-mode FUS was applied to the motor area of the rat brain, and successfully stimulated the motor cortex. The presented techniques can be readily adapted for the transcranial application of FUS to intact human brain. PMID:25232203

Fast Confocal Raman Imaging Using a 2-D Multifocal Array for Parallel Hyperspectral Detection.

PubMed

Kong, Lingbo; Navas-Moreno, Maria; Chan, James W

2016-01-19

We present the development of a novel confocal hyperspectral Raman microscope capable of imaging at speeds up to 100 times faster than conventional point-scan Raman microscopy under high noise conditions. The microscope utilizes scanning galvomirrors to generate a two-dimensional (2-D) multifocal array at the sample plane, generating Raman signals simultaneously at each focus of the array pattern. The signals are combined into a single beam and delivered through a confocal pinhole before being focused through the slit of a spectrometer. To separate the signals from each row of the array, a synchronized scan mirror placed in front of the spectrometer slit positions the Raman signals onto different pixel rows of the detector. We devised an approach to deconvolve the superimposed signals and retrieve the individual spectra at each focal position within a given row. The galvomirrors were programmed to scan different focal arrays following Hadamard encoding patterns. A key feature of the Hadamard detection is the reconstruction of individual spectra with improved signal-to-noise ratio. Using polystyrene beads as test samples, we demonstrated not only that our system images faster than a conventional point-scan method but that it is especially advantageous under noisy conditions, such as when the CCD detector operates at fast read-out rates and high temperatures. This is the first demonstration of multifocal confocal Raman imaging in which parallel spectral detection is implemented along both axes of the CCD detector chip. We envision this novel 2-D multifocal spectral detection technique can be used to develop faster imaging spontaneous Raman microscopes with lower cost detectors.

NASA's university program: Active grants and research contracts, fiscal year 1977

NASA Technical Reports Server (NTRS)

1977-01-01

As basic policy NASA believes that colleges and universities should be encouraged to participate in the nation's space and aeronautics program to the maximum extent practicable. The Office of University Affairs (OUA) serves as a focal point for NASA's relationships with colleges and universities. One of its roles is to provide information on the NASA University Program. The present document is designed to serve several purposes and a wide range of audiences from private individuals to NASA employees. The emphasis is on the technical content of the program, rather than on fiscal data, which is available separately from OUA. As some terminology will not be familiar to all readers, a User's Guide is included to facilitate the fullest use of the material related to the interests of any particular reader.

The postural control can be optimized by the first movement initiation condition encountered when submitted to muscle fatigue.

PubMed

Monjo, Florian; Forestier, Nicolas

2017-08-01

We investigated whether and how the movement initiation condition (IC) encountered during the early movements performed following focal muscle fatigue affects the postural control of discrete ballistic movements. For this purpose, subjects performed shoulder flexions in a standing posture at maximal velocity under two movement IC, i.e., in self-paced conditions and submitted to a Stroop-like task in which participants had to trigger fast shoulder flexions at the presentation of incongruent colors. Shoulder flexion kinematics, surface muscle activity of focal and postural muscles as well as center-of-pressure kinematics were recorded. The initial IC and the order in which subjects were submitted to these two conditions were varied within two separate experimental sessions. IC schedule was repeated before and after fatigue protocols involving shoulder flexors. The aim of this fatigue procedure was to affect acceleration-generating capacities of focal muscles. In such conditions, the postural muscle activity preceding and accompanying movement execution is expected to decrease. Following fatigue, when subjects initially moved in self-paced conditions, postural muscle activity decreased and scaled to the lower focal peak acceleration. This postural strategy then transferred to the Stroop-like task. In contrast, when subjects initially moved submitted to the Stroop-like task, postural muscle activity did not decrease and this transferred to self-paced movements. Regarding the center-of-pressure peak velocity, which is indicative of the efficiency of the postural actions generated in stabilizing posture, no difference appeared between the two sessions post-fatigue. This highlights an optimization of the postural actions when subjects first moved in self-paced conditions, smaller postural muscle activation levels resulting in similar postural consequences. In conclusion, the level of neuromuscular activity associated with the postural control is affected and can be optimized by the initial movement IC experienced post-fatigue. Beyond the fundamental contributions arising from these results, we point out potential applications for trainers and sports instructors. Copyright © 2017 Elsevier B.V. All rights reserved.

47 CFR 215.0 - Purpose and authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.0 Purpose and authority. The purpose of this part is to designate a focal point within the Federal Government for electromagnetic pulse (EMP...

47 CFR 215.0 - Purpose and authority.

Code of Federal Regulations, 2013 CFR

2013-10-01

... POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.0 Purpose and authority. The purpose of this part is to designate a focal point within the Federal Government for electromagnetic pulse (EMP...

47 CFR 215.0 - Purpose and authority.

Code of Federal Regulations, 2011 CFR

2011-10-01

... POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.0 Purpose and authority. The purpose of this part is to designate a focal point within the Federal Government for electromagnetic pulse (EMP...

47 CFR 215.0 - Purpose and authority.

Code of Federal Regulations, 2014 CFR

2014-10-01

... POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.0 Purpose and authority. The purpose of this part is to designate a focal point within the Federal Government for electromagnetic pulse (EMP...

47 CFR 215.0 - Purpose and authority.

Code of Federal Regulations, 2012 CFR

2012-10-01

... POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.0 Purpose and authority. The purpose of this part is to designate a focal point within the Federal Government for electromagnetic pulse (EMP...

A single-chip 32-channel analog beamformer with 4-ns delay resolution and 768-ns maximum delay range for ultrasound medical imaging with a linear array transducer.

PubMed

Um, Ji-Yong; Kim, Yoon-Jee; Cho, Seong-Eun; Chae, Min-Kyun; Kim, Byungsub; Sim, Jae-Yoon; Park, Hong-June

2015-02-01

A single-chip 32-channel analog beamformer is proposed. It achieves a delay resolution of 4 ns and a maximum delay range of 768 ns. It has a focal-point based architecture, which consists of 7 sub-analog beamformers (sub-ABF). Each sub-ABF performs a RX focusing operation for a single focal point. Seven sub-ABFs perform a time-interleaving operation to achieve the maximum delay range of 768 ns. Phase interpolators are used in sub-ABFs to generate sampling clocks with the delay resolution of 4 ns from a low frequency system clock of 5 MHz. Each sub-ABF samples 32 echo signals at different times into sampling capacitors, which work as analog memory cells. The sampled 32 echo signals of each sub-ABF are originated from one target focal point at one instance. They are summed at one instance in a sub-ABF to perform the RX focusing for the target focal point. The proposed ABF chip has been fabricated in a 0.13- μ m CMOS process with an active area of 16 mm (2). The total power consumption is 287 mW. In measurement, the digital echo signals from a commercial ultrasound medical imaging machine were applied to the fabricated chip through commercial DAC chips. Due to the speed limitation of the DAC chips, the delay resolution was relaxed to 10 ns for the real-time measurement. A linear array transducer with no steering operation is used in this work.

An improved schlieren method for measurement and automatic reconstruction of the far-field focal spot

PubMed Central

Wang, Zhengzhou; Hu, Bingliang; Yin, Qinye

2017-01-01

The schlieren method of measuring far-field focal spots offers many advantages at the Shenguang III laser facility such as low cost and automatic laser-path collimation. However, current methods of far-field focal spot measurement often suffer from low precision and efficiency when the final focal spot is merged manually, thereby reducing the accuracy of reconstruction. In this paper, we introduce an improved schlieren method to construct the high dynamic-range image of far-field focal spots and improve the reconstruction accuracy and efficiency. First, a detection method based on weak light beam sampling and magnification imaging was designed; images of the main and side lobes of the focused laser irradiance in the far field were obtained using two scientific CCD cameras. Second, using a self-correlation template matching algorithm, a circle the same size as the schlieren ball was dug from the main lobe cutting image and used to change the relative region of the main lobe cutting image within a 100×100 pixel region. The position that had the largest correlation coefficient between the side lobe cutting image and the main lobe cutting image when a circle was dug was identified as the best matching point. Finally, the least squares method was used to fit the center of the side lobe schlieren small ball, and the error was less than 1 pixel. The experimental results show that this method enables the accurate, high-dynamic-range measurement of a far-field focal spot and automatic image reconstruction. Because the best matching point is obtained through image processing rather than traditional reconstruction methods based on manual splicing, this method is less sensitive to the efficiency of focal-spot reconstruction and thus offers better experimental precision. PMID:28207758

Focal Adhesion Induction at the Tip of a Functionalized Nanoelectrode

PubMed Central

Fuentes, Daniela E.; Bae, Chilman; Butler, Peter J.

2012-01-01

Cells dynamically interact with their physical micro-environment through the assembly of nascent focal contacts and focal adhesions. The dynamics and mechanics of these contact points are controlled by transmembrane integrins and an array of intracellular adaptor proteins. In order to study the mechanics and dynamics of focal adhesion assembly, we have developed a technique for the timed induction of a nascent focal adhesion. Bovine aortic endothelial cells were approached at the apical surface by a nanoelectrode whose position was controlled with a resolution of 10s of nanometers using changes in electrode current to monitor distance from the cell surface. Since this probe was functionalized with fibronectin, a focal contact formed at the contact location. Nascent focal adhesion assembly was confirmed using time-lapse confocal fluorescent images of red fluorescent protein (RFP) – tagged talin, an adapter protein that binds to activated integrins. Binding to the cell was verified by noting a lack of change of electrode current upon retraction of the electrode. This study demonstrates that functionalized nanoelectrodes can enable precisely-timed induction and 3-D mechanical manipulation of focal adhesions and the assay of the detailed molecular kinetics of their assembly. PMID:22247742

Improvements of the Ray-Tracing Based Method Calculating Hypocentral Loci for Earthquake Location

NASA Astrophysics Data System (ADS)

Zhao, A. H.

2014-12-01

Hypocentral loci are very useful to reliable and visual earthquake location. However, they can hardly be analytically expressed when the velocity model is complex. One of methods numerically calculating them is based on a minimum traveltime tree algorithm for tracing rays: a focal locus is represented in terms of ray paths in its residual field from the minimum point (namely initial point) to low residual points (referred as reference points of the focal locus). The method has no restrictions on the complexity of the velocity model but still lacks the ability of correctly dealing with multi-segment loci. Additionally, it is rather laborious to set calculation parameters for obtaining loci with satisfying completeness and fineness. In this study, we improve the ray-tracing based numerical method to overcome its advantages. (1) Reference points of a hypocentral locus are selected from nodes of the model cells that it goes through, by means of a so-called peeling method. (2) The calculation domain of a hypocentral locus is defined as such a low residual area that its connected regions each include one segment of the locus and hence all the focal locus segments are respectively calculated with the minimum traveltime tree algorithm for tracing rays by repeatedly assigning the minimum residual reference point among those that have not been traced as an initial point. (3) Short ray paths without branching are removed to make the calculated locus finer. Numerical tests show that the improved method becomes capable of efficiently calculating complete and fine hypocentral loci of earthquakes in a complex model.

Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation

PubMed Central

2011-01-01

Active myofascial trigger points are one of the major peripheral pain generators for regional and generalized musculoskeletal pain conditions. Myofascial trigger points are also the targets for acupuncture and/or dry needling therapies. Recent evidence in the understanding of the pathophysiology of myofascial trigger points supports The Integrated Hypothesis for the trigger point formation; however unanswered questions remain. Current evidence shows that spontaneous electrical activity at myofascial trigger point originates from the extrafusal motor endplate. The spontaneous electrical activity represents focal muscle fiber contraction and/or muscle cramp potentials depending on trigger point sensitivity. Local pain and tenderness at myofascial trigger points are largely due to nociceptor sensitization with a lesser contribution from non-nociceptor sensitization. Nociceptor and non-nociceptor sensitization at myofascial trigger points may be part of the process of muscle ischemia associated with sustained focal muscle contraction and/or muscle cramps. Referred pain is dependent on the sensitivity of myofascial trigger points. Active myofascial trigger points may play an important role in the transition from localized pain to generalized pain conditions via the enhanced central sensitization, decreased descending inhibition and dysfunctional motor control strategy. PMID:21439050

Separation of distinct adhesion complexes and associated cytoskeleton by a micro-stencil-printing method.

PubMed

Caballero, David; Osmani, Naël; Georges-Labouesse, Elisabeth; Labouesse, Michel; Riveline, Daniel

2012-01-01

Adhesion between cells and the extracellular matrix is mediated by different types of transmembraneous proteins. Their associations to specific partners lead to the assembly of contacts such as focal adhesions and hemidesmosomes. The spatial overlap between both contacts within cells has however limited the study of each type of contact. Here we show that with "stampcils" focal contacts and hemidesmosomes can be spatially separated: cells are plated within the cavities of a stencil and the grids of the stencil serve as stamps for grafting an extracellular matrix protein-fibronectin. Cells engage new contacts on stamped zones leading to the segregation of adhesions and their associated cytoskeletons, i.e., actin and intermediate filaments of keratins. This new method should provide new insights into cell contacts compositions and dynamics.

Motor training reduces surround inhibition in the motor cortex.

PubMed

Akkad, Haya; Di Stasio, Flavio; Tibold, Robert; Kassavetis, Panagiotis; Rothwell, John C; Edwards, Mark J

2016-06-01

Surround inhibition (SI) is thought to facilitate focal contraction of a hand muscle by keeping nearby muscles silent. Unexpectedly, SI is reduced in skilled pianists. We tested whether repeated practice of focal contraction in non-pianists could reduce SI. Motor-evoked potentials were elicited by transcranial magnetic stimulation in the relaxed abductor digiti minimi randomly at the onset and 5s after offset of a 2s focal contraction (10% maximum) of the first dorsal interosseous (FDI). Over 5 blocks of 40 trials participants obtained points for increasing contraction speed and stability in FDI. In a final block, the interval between contractions was varied randomly to increase attention to the task. Over the first 5 blocks, SI declined as performance (points scored) improved. In the final "attention" block SI increased towards baseline without affecting performance. Although SI may be useful during the early stages of learning, skilled focal finger movement does not require SI to prevent activity in non-involved muscles. This could be due to better targeting of the excitatory command to move. Results from the final block suggest that increased attention can re-engage SI when task parameters change. SI is not necessary for successful focal contraction, but may contribute during learning and during attention to task. Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Conical refraction and formation of multiring focal image with Laguerre-Gauss light beams.

PubMed

Peet, Viktor

2011-08-01

For a light beam focused through a biaxial crystal along one of its optical axes, the effect of internal conical refraction in the crystal leads to the formation in the focal image plane of two bright rings separated by a dark ring. It is shown that, with circularly polarized Laguerre-Gauss LG(0)(ℓ) beams entering the crystal, this classical double-ring pattern is transformed into a multiring one consisting of ℓ+2 bright rings. © 2011 Optical Society of America

Analysis of the intraocular jet flows and pressure gradients induced by air and fluid infusion: mechanism of focal chorioretinal damage.

PubMed

Kim, Yong Joon; Jo, Sungkil; Moon, Daruchi; Joo, Youngcheol; Choi, Kyung Seek

2014-05-01

To comprehend the mechanism of focal chorioretinal damage by analysis of the pressure distribution and dynamic pressure induced by infused air during fluid-air exchange. A precise simulation featuring a model eye and a fluid circuit was designed to analyze fluid-air exchange. The pressure distribution, flow velocity, and dynamic pressure induced by infusion of air into an air-filled eye were analyzed using an approach based on fluid dynamics. The size of the port and the infusion pressure were varied during simulated iterations. We simulated infusion of an air-filled eye with balanced salt solution (BSS) to better understand the mechanism of chorioretinal damage induced by infused air. Infused air was projected straight toward a point on the retina contralateral to the infusion port (the "vulnerable point"). The highest pressure was evident at the vulnerable point, and the lowest pressure was recorded on most retinal areas. Simulations using greater infusion pressure and a port of larger size were associated with elevations in dynamic pressure and the pressure gradient. The pressure gradients were 2.8 and 5.1 mm Hg, respectively, when infusion pressures of 30 and 50 mm Hg were delivered through a 20-gauge port. The pressure gradient associated with BSS infusion was greater than that created by air, but lasted for only a moment. Our simulation explains the mechanism of focal chorioretinal damage in numerical terms. Infused air induces a prolonged increase in focal pressure on the vulnerable point, and this may be responsible for visual field defects arising after fluid-air exchange. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

Focus collimator press for a collimator for gamma ray cameras

DOE Office of Scientific and Technical Information (OSTI.GOV)

York, R.N.; York, D.L.

A focus collimator press for collimators for gamma ray cameras is described comprising a pivot arm of fixed length mounted on a travelling pivot which is movable in the plane of a spaced apart work table surface in a direction toward and away from the work table. A press plate is carried at the opposite end of the fixed length pivot arm, and is maintained in registration with the same portion of the work table for pressing engagement with each undulating radiation opaque strip as it is added to the top of a collimator stack in process by movement ofmore » the travelling pivot inward toward the work table. This enables the press plate to maintain its relative position above the collimator stack and at the same time the angle of the press plate changes, becoming less acute in relation to the work table as the travelling pivot motes inwardly toward the work table. The fixed length of the pivot arm is substantially equal to the focal point of the converging apertures formed by each pair of undulating strips stacked together. Thus, the focal point of each aperture row falls substantially on the axis of the travelling pivot, and since it moves in the plane of the work table surface the focal point of each aperture row is directed to lie in the same common plane. When one of two collimator stacks made in this way is rotated 180 degrees and the two bonded together along their respective first strips, all focal points of every aperture row lie on the central axis of the completed collimator.« less

[Adipose-derived stem cell transplantation promotes the expression of netrin-1 in the rat cortex after focal cerebral ischemia].

PubMed

Wang, Jiehua; Hong, Zhuquan; Pan, Ying; Li, Guoqian

2017-01-01

Objective To observe the effect of adipose-derived stem cells (ADSCs) transplantation on the expression of netrin-1 in rats after focal cerebral ischemia. Methods Male SD rats were randomly divided into control group, model group and ADSC group. ADSCs were harvested and purified. Focal cerebral ischemia models were established in rats by the suture method. ADSCs were injected into the lateral ventricle of ADSC group rats and the same does of PBS was given to model group rats. At day 4, 7 and 14 after reperfusion, six rats were sacrificed to remove the brain tissues at each time point. The expression of netrin-1 was detected by reverse-transcription PCR, Western blotting and immunohistochemistry. Results Compared with the control group, the expression of netrin-1 in the brain tissues of the model group increased after focal cerebral ischemia, reached the peak at 4 days, and the expression of netrin-1 was significantly higher than that of the control group at each time point. Compared with the model group, the expression of netrin-1 in the ADSC group increased further, reached the peak at 7 days, and the expression of netrin-1 in the ADSC group was significantly higher than that of the model group at each time point. Conclusion ADSC transplantation could up-regulate the expression of netrin-1, and promote axon regeneration and the recovery of neurological functions.

Cigarette Ads and Youth.

ERIC Educational Resources Information Center

Carol, Julia

1988-01-01

Points out ways the tobacco industry markets products to youth, including paid advertisements, sponsorship of sporting events, music concerts, and magazines. Relates several focal points for smoking prevention, which include deglamorization of cigarette advertisements and making smoking socially undesirable. (LS)

Mesenchymal stem cells cultured on magnetic nanowire substrates

NASA Astrophysics Data System (ADS)

Perez, Jose E.; Ravasi, Timothy; Kosel, Jürgen

2017-02-01

Stem cells have been shown to respond to extracellular mechanical stimuli by regulating their fate through the activation of specific signaling pathways. In this work, an array of iron nanowires (NWs) aligned perpendicularly to the surface was fabricated by pulsed electrodepositon in porous alumina templates followed by a partial removal of the alumina to reveal 2-3 μm of the NWs. This resulted in alumina substrates with densely arranged NWs of 33 nm in diameter separated by 100 nm. The substrates were characterized by scanning electron microscopy (SEM) energy dispersive x-ray analysis and vibrating sample magnetometer. The NW array was then used as a platform for the culture of human mesenchymal stem cells (hMSCs). The cells were stained for the cell nucleus and actin filaments, as well as immuno-stained for the focal adhesion protein vinculin, and then observed by fluorescence microscopy in order to characterize their spreading behavior. Calcein AM/ethidium homodimer-1 staining allowed the determination of cell viability. The interface between the cells and the NWs was studied using SEM. Results showed that hMSCs underwent a re-organization of actin filaments that translated into a change from an elongated to a spherical cell shape. Actin filaments and vinculin accumulated in bundles, suggesting the attachment and formation of focal adhesion points of the cells on the NWs. Though the overall number of cells attached on the NWs was lower compared to the control, the attached cells maintained a high viability (>90%) for up to 6 d. Analysis of the interface between the NWs and the cells confirmed the re-organization of F-actin and revealed the adhesion points of the cells on the NWs. Additionally, a net of filopodia surrounded each cell, suggesting the probing of the array to find additional adhesion points. The cells maintained their round shape for up to 6 d of culture. Overall, the NW array is a promising nanostructured platform for studying and influencing hMSCs differentiation.

Method and apparatus for aligning a solar concentrator using two lasers

DOEpatents

Diver Jr., Richard Boyer

2003-07-22

A method and apparatus are provided for aligning the facets of a solar concentrator. A first laser directs a first laser beam onto a selected facet of the concentrator such that a target board positioned adjacent to the first laser at approximately one focal length behind the focal point of the concentrator is illuminated by the beam after reflection thereof off of the selected facet. A second laser, located adjacent to the vertex of the optical axis of the concentrator, is used to direct a second laser beam onto the target board at a target point thereon. By adjusting the selected facet to cause the first beam to illuminate the target point on the target board produced by the second beam, the selected facet can be brought into alignment with the target point. These steps are repeated for other selected facets of the concentrator, as necessary, to provide overall alignment of the concentrator.

Distortion of Dynamical Systems in the Context of Focusing the Chaos Around the Point

NASA Astrophysics Data System (ADS)

Pawlak, Ryszard J.

In the paper, we examine local aspects of chaos for self-functions on topological manifolds. For this purpose, issues related to focal entropy points and homoclinic points are used. We consider also distortion of dynamical systems which is a theoretical analogue to wave interference.

Update on the Use of Botulinum Toxin Therapy for Focal and Task-Specific Dystonias.

PubMed

Lungu, Codrin; Ahmad, Omar F

2016-02-01

Focal dystonia is defined by anatomical distribution and represents a distinct entity from generalized dystonia. Task-specific dystonia occurs in the context of specific patterns of movement. Botulinum neurotoxin (BoNT) injections are the treatment of choice in most cases. Several formulations are available; the approved indications, dosing, and some administration details, differ between them. The major forms of focal and task-specific dystonia are reviewed, along with the evidence for BoNT therapy, the expected benefit and side effects, and practical points guiding the injections. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Usage of the Upgraded Vassilissa Separator for Synthesis of Super-Heavy Elements

NASA Astrophysics Data System (ADS)

Yeremin, A. V.; Malyshev, O. N.; Popeko, A. G.; Sagaidak, R. N.; Chepigin, V. I.; Kabachenko, A. P.; Belozerov, A. V.; Chelnokov, M. L.; Gorshkov, V. A.; Svirikhin, A. I.; Korotkov, S. P.; Rohach, J.; Brida, I.; Berek, G.

2002-12-01

Electrostatic separator VASSILISSA is used for exploring complete fussion nuclear reactions. The magnetic analyzer, based on D37 dipole magnet, was installed after the second triplet of quadrupole lenses of the separator for the mass identification of evaporation residues. Mass identification is an powerful tool for identification of recoil atoms of super-heavy elements. The new detection system consisting of the time-of-fiight system and 32-strips position-sensitive detector array was installed in the focal plane of the separator. The mass resolution of the separator after upgrade was found to be about 2.5 %.

Mirror with thermally controlled radius of curvature

DOEpatents

Neil, George R.; Shinn, Michelle D.

2010-06-22

A radius of curvature controlled mirror for controlling precisely the focal point of a laser beam or other light beam. The radius of curvature controlled mirror provides nearly spherical distortion of the mirror in response to differential expansion between the front and rear surfaces of the mirror. The radius of curvature controlled mirror compensates for changes in other optical components due to heating or other physical changes. The radius of curvature controlled mirror includes an arrangement for adjusting the temperature of the front surface and separately adjusting the temperature of the rear surface to control the radius of curvature. The temperature adjustment arrangements can include cooling channels within the mirror body or convection of a gas upon the surface of the mirror. A control system controls the differential expansion between the front and rear surfaces to achieve the desired radius of curvature.

Silhouettes - An automated three-dimensional plume visualization and tracking system for environmental monitoring

NASA Technical Reports Server (NTRS)

Cambridge, Vivien J.; Magee, Ronald G.

1993-01-01

The method of silhouettes proceeds from the premise that the 3D location and shape of an arbitrary object can be approximated via the cross section of a series of conical volumes whose focal points are arranged at sites surrounding the object; the projection of each conical volume onto a picture plane at each focal point is identical to a projection of the outline of the object onto that picture plane. Attention is presently given to the use of the silhouettes method for gas plume dispersion monitoring through the 3D reconstruction of plumes from imagery acquired at strategically located stations in the plumes' path.

Solar Thermal Propulsion Test

NASA Technical Reports Server (NTRS)

1999-01-01

Researchers at the Marshall Space Flight Center (MSFC) have designed, fabricated, and tested the first solar thermal engine, a non-chemical rocket engine that produces lower thrust but has better thrust efficiency than a chemical combustion engine. MSFC turned to solar thermal propulsion in the early 1990s due to its simplicity, safety, low cost, and commonality with other propulsion systems. Solar thermal propulsion works by acquiring and redirecting solar energy to heat a propellant. The 20- by 24-ft heliostat mirror (not shown in this photograph) has a dual-axis control that keeps a reflection of the sunlight on the 18-ft diameter concentrator mirror, which then focuses the sunlight to a 4-in focal point inside the vacuum chamber. The focal point has 10 kilowatts of intense solar power. This image, taken during the test, depicts the light being concentrated into the focal point inside the vacuum chamber. As part of MSFC's Space Transportation Directorate, the Propulsion Research Center serves as a national resource for research of advanced, revolutionary propulsion technologies. The mission is to move the Nation's capabilities beyond the confines of conventional chemical propulsion into an era of aircraft-like access to Earth orbit, rapid travel throughout the solar system, and exploration of interstellar space.

Research Technology

NASA Image and Video Library

1999-03-01

Researchers at the Marshall Space Flight Center (MSFC) have designed, fabricated, and tested the first solar thermal engine, a non-chemical rocket engine that produces lower thrust but has better thrust efficiency than a chemical combustion engine. MSFC turned to solar thermal propulsion in the early 1990s due to its simplicity, safety, low cost, and commonality with other propulsion systems. Solar thermal propulsion works by acquiring and redirecting solar energy to heat a propellant. The 20- by 24-ft heliostat mirror (not shown in this photograph) has a dual-axis control that keeps a reflection of the sunlight on the 18-ft diameter concentrator mirror, which then focuses the sunlight to a 4-in focal point inside the vacuum chamber. The focal point has 10 kilowatts of intense solar power. This image, taken during the test, depicts the light being concentrated into the focal point inside the vacuum chamber. As part of MSFC's Space Transportation Directorate, the Propulsion Research Center serves as a national resource for research of advanced, revolutionary propulsion technologies. The mission is to move the Nation's capabilities beyond the confines of conventional chemical propulsion into an era of aircraft-like access to Earth orbit, rapid travel throughout the solar system, and exploration of interstellar space.

Development and performance evaluation of an electromagnetic-type shock wave generator for lipolysis.

PubMed

Liang, S M; Chang, M H; Yang, Z Y

2014-01-01

This study aims at the design and development of electromagnetic-type intermittent shock wave generation in a liquid. The shock wave generated is focused at a focal point through an acoustic lens. This hardware device mainly consists of a full-wave bridge rectifier, 6 capacitors, a spark gap, and a flat coil. A metal disk is mounted in a liquid-filled tube and is placed in close proximity to the flat coil. Due to the repulsive force existing between the coil and disk shock waves are generated, while an eddy current is induced in the metal disk. Some components and materials associated with the device are also described. By increasing the capacitance content to enhance electric energy level, a highly focused pressure can be achieved at the focal point through an acoustic lens in order to lyse fat tissue. Focused pressures were measured at the focal point and its vicinity for different operation voltages. The designed shock wave generator with an energy intensity of 0.0016 mJ/mm(2) (at 4 kV) and 2000 firings or higher energy intensities with 1000 firings is found to be able to disrupt pig fat tissue.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liang, S. M., E-mail: liangsm@cc.feu.edu.tw; Yang, Z. Y.; Chang, M. H.

This study aims at the design and development of electromagnetic-type intermittent shock wave generation in a liquid. The shock wave generated is focused at a focal point through an acoustic lens. This hardware device mainly consists of a full-wave bridge rectifier, 6 capacitors, a spark gap, and a flat coil. A metal disk is mounted in a liquid-filled tube and is placed in close proximity to the flat coil. Due to the repulsive force existing between the coil and disk shock waves are generated, while an eddy current is induced in the metal disk. Some components and materials associated withmore » the device are also described. By increasing the capacitance content to enhance electric energy level, a highly focused pressure can be achieved at the focal point through an acoustic lens in order to lyse fat tissue. Focused pressures were measured at the focal point and its vicinity for different operation voltages. The designed shock wave generator with an energy intensity of 0.0016 mJ/mm{sup 2} (at 4 kV) and 2000 firings or higher energy intensities with 1000 firings is found to be able to disrupt pig fat tissue.« less

A 15kWe (nominal) solar thermal electric power conversion concept definition study: Steam Rankine reheat reciprocator system

NASA Technical Reports Server (NTRS)

Fuller, H.; Demler, R.; Poulin, E.; Dantowitz, P.

1979-01-01

An evaluation was made of the potential of a steam Rankine reheat reciprocator engine to operate at high efficiency in a point-focusing distributed receiver solar thermal-electric power system. The scope of the study included the engine system and electric generator; not included was the solar collector/mirror or the steam generator/receiver. A parametric analysis of steam conditions was completed leading to the selection of 973 K 12.1 MPa as the steam temperature/pressure for a conceptual design. A conceptual design was completed for a two cylinder/ opposed engine operating at 1800 rpm directly coupled to a commercially available induction generator. A unique part of the expander design is the use of carbon/graphite piston rings to eliminate the need for using oil as an upper cylinder lubricant. The evaluation included a system weight estimate of 230 kg at the mirror focal point with the condenser mounted separately on the ground. The estimated cost of the overall system is $1932 or $90/kW for the maximum 26 kW output.

Telephoto axicon

NASA Astrophysics Data System (ADS)

Burvall, Anna; Goncharov, Alexander; Dainty, Chris

2005-09-01

The axicon is an optical element which creates a narrow focal line along the optical axis, unlike the single focal point produced by a lens. The long and precisely defined axicon focal line is used e.g. in alignment, or to extend the depth of focus of existing methods such as optical coherence tomography or light sectioning. Axicons are generally manufactured as refractive cones or diffractive circular gratings. They are also made as lens systems or doublet lenses, which are easier to produce. We present a design in the form of a reflective-refractive single-element device with annular aperture. This very compact system has only two surfaces, which can be spherical or aspheric depending on the quality required of the focal line. Both surfaces have reflective coatings at specific zones, providing an annular beam suitable for generating extended focal lines. One draw-back of a normal axicon is its sensitivity to the angle of illumination. Even for relatively small angles, astigmatism will broaden the focus and give it an asteroid shape. For our design, with spherical surfaces concentric about the center of the entrance pupil, the focal line remains unchanged in off-axis illumination.

Statistical earthquake focal mechanism forecasts

NASA Astrophysics Data System (ADS)

Kagan, Yan Y.; Jackson, David D.

2014-04-01

Forecasts of the focal mechanisms of future shallow (depth 0-70 km) earthquakes are important for seismic hazard estimates and Coulomb stress, and other models of earthquake occurrence. Here we report on a high-resolution global forecast of earthquake rate density as a function of location, magnitude and focal mechanism. In previous publications we reported forecasts of 0.5° spatial resolution, covering the latitude range from -75° to +75°, based on the Global Central Moment Tensor earthquake catalogue. In the new forecasts we have improved the spatial resolution to 0.1° and the latitude range from pole to pole. Our focal mechanism estimates require distance-weighted combinations of observed focal mechanisms within 1000 km of each gridpoint. Simultaneously, we calculate an average rotation angle between the forecasted mechanism and all the surrounding mechanisms, using the method of Kagan & Jackson proposed in 1994. This average angle reveals the level of tectonic complexity of a region and indicates the accuracy of the prediction. The procedure becomes problematical where longitude lines are not approximately parallel, and where shallow earthquakes are so sparse that an adequate sample spans very large distances. North or south of 75°, the azimuths of points 1000 km away may vary by about 35°. We solved this problem by calculating focal mechanisms on a plane tangent to the Earth's surface at each forecast point, correcting for the rotation of the longitude lines at the locations of earthquakes included in the averaging. The corrections are negligible between -30° and +30° latitude, but outside that band uncorrected rotations can be significantly off. Improved forecasts at 0.5° and 0.1° resolution are posted at http://eq.ess.ucla.edu/kagan/glob_gcmt_index.html.

Truncation of the secondary concentrator (CPC) between maximum performances and economical requirements

NASA Astrophysics Data System (ADS)

Segal, A.; Epstein, M.

2009-08-01

A central solar plant, based on beam-down optics, is composed of a field of heliostats, a tower reflector and a ground receiver. The tower reflector is an optical system comprises of a quadric surface mirror (hyperboloid), where its upper focal point coincides with the aim point of a heliostat field and its lower focal point is located at a specified height, coinciding with the entrance plane of the ground receiver. The optics of a tower reflector requires the use of ground secondary concentrator, composed of a cluster of CPCs, because the quadric surface mirror always magnifies the sun image. There is an intrinsic correlation between the tower reflector position and its size on one hand, and the geometry, dimensions and reflective area of the secondary concentrator on the other hand; both are related to the heliostat field reflective area. Obviously, when one wishes to have a smaller tower reflector by placing it closer to the upper focal point, the image created at the lower focus will be larger, resulting in a larger secondary ground concentrator. The present work analyses the ways for a substantial decrease of the size of the ground concentrator cluster (and, implicit, the concentrators area) via truncation, without significant sacrifice of the performance, although some increase of the optical losses is inevitable. This offers a method for cost effective design of future central solar plants utilizing the beam down optics.

The Role of Interface Shape on the Impact Characteristics and Cranial Fracture Patterns Using the Immature Porcine Head Model,.

PubMed

Vaughan, Patrick E; Vogelsberg, Caitlin C M; Vollner, Jennifer M; Fenton, Todd W; Haut, Roger C

2016-09-01

The forensic literature suggests that when adolescents fall onto edged and pointed surfaces, depressed fractures can occur at low energy levels. This study documents impact biomechanics and fracture characteristics of infant porcine skulls dropped onto flat, curved, edged, and focal surfaces. Results showed that the energy needed for fracture initiation was nearly four times higher against a flat surface than against the other surfaces. While characteristic measures of fracture such as number and length of fractures did not vary with impact surface shape, the fracture patterns did depend on impact surface shape. While experimental impacts against the flat surface produced linear fractures initiating at sutural boundaries peripheral to the point of impact (POI), more focal impacts produced depressed fractures initiating at the POI. The study supported case-based forensic literature suggesting cranial fracture patterns depend on impact surface shape and that fracture initiation energy is lower for more focal impacts. © 2016 American Academy of Forensic Sciences.

[Laparoscopy findings of the yellow spot, a focal fatty liver infiltration].

PubMed

Koch, H; Henning, H; Friedrich, K; Lüders, C J

1984-05-01

From 1976 to 1982 in 279 patients amongst 3719 laparoscopies focal fatty liver infiltrates were found at the right and/or left liver edge next to the insertion point of the round ligament. These so-called "yellow spots" mainly could be recognized in case of normal liver tissue and in cases suffering from chronic hepatitis insofar as a cirrhotic transformation or a significant fibrosis had not taken place. The localization and the shape of these focal lesions indicate, that an abnormality in the portal blood supply of the corresponding area may play an etiologic role for the development of the fatty infiltration.

The design and assembly of aluminum mirrors of a three-mirror-anastigmat telescope

NASA Astrophysics Data System (ADS)

Chang, Shenq-Tsong; Lin, Yu-Chuan; Wu, Kun-Huan; Lien, Chun-Chieh; Huang, Ting-Ming; Tsay, Ho-Lin; Chan, Chia-Yen

2017-09-01

Better ground sampling distance (GSD) has been a trend for earth observation satellites. A long-focal-length telescope is required accordingly in systematic point of view. On the other hand, there is size constraint for such long-focal-length telescope especially in space projects. Three-mirror-anastigmat (TMA) was proven to have excellent features of correcting aberrations, wide spectral range and shorter physical requirement [1-3].

Tuskegee as Sacred Rhetoric: Focal Point for the Emergent Field of African American Religion and Health.

PubMed

Laws, Terri

2018-02-01

Scholars in African American religion engage the Tuskegee Syphilis Study as the focal point of the African American experience in institutional medicine. Seeking a way forward from this history and its intentional evil, the author proposes to position Tuskegee as a form of Lynch's culturally contextual sacred rhetoric to make use of its metaphoric value in the emerging field of African American religion and health. In this broader meaning-making frame, Tuskegee serves as a reminder that African American religious sensibility has long been an agential resource that counters abuse of the Black body. It also acknowledges the complex decisions facing African American clinical trial participants.

Visible and infrared linear detector arrays for the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS)

NASA Technical Reports Server (NTRS)

Bailey, Gary C.

1987-01-01

The Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) instrument uses four separate focal plane assemblies consisting of line array detectors that are multiplexed to a common J-FET preamp using a FET switch multiplexing (MUX) technique. A 32-element silicon line array covers the spectral range from 0.41 to 0.70 microns. Three additional 64-element indium antimonide (InSb) line arrays cover the spectral range from 0.68 to 2.45 microns. The spectral sampling interval per detector element is nominally 9.8 nm, giving a total of 224 spectral channels. All focal planes operate at liquid nitrogen temperature and are housed in separate dewars. Electrical performance characteristics include a read noise of less than 1000 e(-) in all channels, response and dark nonuniformity of 5 percent peak to peak, and quantum efficiency of greater than 60 percent.

The recoil transfer chamber—An interface to connect the physical preseparator TASCA with chemistry and counting setups

NASA Astrophysics Data System (ADS)

Even, J.; Ballof, J.; Brüchle, W.; Buda, R. A.; Düllmann, Ch. E.; Eberhardt, K.; Gorshkov, A.; Gromm, E.; Hild, D.; Jäger, E.; Khuyagbaatar, J.; Kratz, J. V.; Krier, J.; Liebe, D.; Mendel, M.; Nayak, D.; Opel, K.; Omtvedt, J. P.; Reichert, P.; Runke, J.; Sabelnikov, A.; Samadani, F.; Schädel, M.; Schausten, B.; Scheid, N.; Schimpf, E.; Semchenkov, A.; Thörle-Pospiech, P.; Toyoshima, A.; Türler, A.; Vicente Vilas, V.; Wiehl, N.; Wunderlich, T.; Yakushev, A.

2011-05-01

Performing experiments with transactinide elements demands highly sensitive detection methods due to the extremely low production rates (one -atom -at -a -time conditions). Preseparation with a physical recoil separator is a powerful method to significantly reduce the background in experiments with sufficiently long-lived isotopes ( t1/2≥0.5 s). In the last years, the new gas-filled TransActinide Separator and Chemistry Apparatus (TASCA) was installed and successfully commissioned at GSI. Here, we report on the design and performance of a Recoil Transfer Chamber (RTC) for TASCA—an interface to connect various chemistry and counting setups with the separator. Nuclear reaction products recoiling out of the target are separated according to their magnetic rigidity within TASCA, and the wanted products are guided to the focal plane of TASCA. In the focal plane, they pass a thin Mylar window that separates the ˜1 mbar atmosphere in TASCA from the RTC kept at ˜1 bar. The ions are stopped in the RTC and transported by a continuous gas flow from the RTC to the ancillary setup. In this paper, we report on measurements of the transportation yields under various conditions and on the first chemistry experiments at TASCA—an electrochemistry experiment with osmium and an ion exchange experiment with the transactinide element rutherfordium.

Phase-Scrambler Plate Spreads Point Image

NASA Technical Reports Server (NTRS)

Edwards, Oliver J.; Arild, Tor

1992-01-01

Array of small prisms retrofit to imaging lens. Phase-scrambler plate essentially planar array of small prisms partitioning aperture of lens into many subapertures, and prism at each subaperture designed to divert relatively large diffraction spot formed by that subaperture to different, specific point on focal plane.

The Relation Between Lung Dust and Lung Pathology in Pneumoconiosis*

PubMed Central

Nagelschmidt, G.

1960-01-01

Methods of isolation and analysis of dust from pneumoconiotic lungs are reviewed, and the results of lung dust analyses for different forms of pneumoconiosis are presented. A tentative classification separates beryllium, aluminium, abrasive fume, and asbestos, which cause interstitial or disseminated fibrosis from quartz, coal, haematite, talc, kaolin, and other dusts, which cause a nodular or focal fibrosis which may change to forms with massive lesions. The data suggest that in the first, but not in the second, group the dusts are relatively soluble; only in the second group do amounts of dust and severity of fibrosis go in parallel for a given form of pneumoconiosis. In classical silicosis the quartz percentage is higher and the amount of total dust much lower than in coal-miners' pneumoconiosis. Mixed forms of both groups occur, for instance, in diatomite workers. The need for more research, especially in the first group, is pointed out. Images PMID:13727444

High spatial resolution technique for SPECT using a fan-beam collimator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ichihar, T.; Nambu, K.; Motomura, N.

1993-08-01

The physical characteristics of the collimator cause degradation of resolution with increasing distance from the collimator surface. A new convolutional backprojection algorithm has been derived for fanbeam SPECT data without rebinding into parallel beam geometry. The projections are filtered and then backprojected into the area within an isosceles triangle whose vertex is the focal point of the fan-beam and whose base is the fan-beam collimator face, and outside of the circle whose center is located midway between the focal point and the center of rotation and whose diameter is the distance between the focal point and the center of rotation.more » Consequently the backprojected area is close to the collimator surface. This algorithm has been implemented on a GCA-9300A SPECT system showing good results with both phantom and patient studies. The SPECT transaxial resolution was 4.6mm FWHM (reconstructed image matrix size of 256x256) at the center of SPECT FOV using UHR (ultra-high-resolution) fan beam collimators for brain study. Clinically, Tc-99m HMPAO and Tc-99m ECD brain data were reconstructed using this algorithm. The reconstruction results were compared with MRI images of the same slice position and showed significantly improved over results obtained with standard reconstruction algorithms.« less

Research Technology

NASA Image and Video Library

1999-08-01

Researchers at the Marshall Space Flight Center (MSFC) have designed, fabricated, and tested the first solar thermal engine, a non-chemical rocket engine that produces lower thrust but has better thrust efficiency than a chemical combustion engine. MSFC turned to solar thermal propulsion in the early 1990s due to its simplicity, safety, low cost, and commonality with other propulsion systems. Solar thermal propulsion works by acquiring and redirecting solar energy to heat a propellant. The 20- by 24-ft heliostat mirror (not shown in this photograph) has dual-axis control that keeps a reflection of the sunlight on an 18-ft diameter concentrator mirror, which then focuses the sunlight to a 4-in focal point inside the vacuum chamber. The focal point has 10 kilowatts of intense solar power. This photograph is a close-up view of a 4-in focal point inside the vacuum chamber at the MSFC Solar Thermal Propulsion Test facility. As part of MSFC's Space Transportation Directorate, the Propulsion Research Center serves as a national resource for research of advanced, revolutionary propulsion technologies. The mission is to move the Nation's capabilities beyond the confines of conventional chemical propulsion into an era of aircraft-like access to Earth orbit, rapid travel throughout the solar system, and exploration of interstellar space.

Research Technology

NASA Image and Video Library

1999-08-01

Researchers at the Marshall Space Flight Center (MSFC) have designed, fabricated and tested the first solar thermal engine, a non-chemical rocket engine that produces lower thrust but has better thrust efficiency than a chemical combustion engine. MSFC turned to solar thermal propulsion in the early 1990s due to its simplicity, safety, low cost, and commonality with other propulsion systems. Solar thermal propulsion works by acquiring and redirecting solar energy to heat a propellant. This photograph, taken at MSFC's Solar Thermal Propulsion Test Facility, shows a concentrator mirror, a combination of 144 mirrors forming this 18-ft diameter concentrator, and a vacuum chamber that houses the focal point. The 20- by 24-ft heliostat mirror (not shown in this photograph) has a dual-axis control that keeps a reflection of the sunlight on the 18-foot diameter concentrator mirror, which then focuses the sunlight to a 4-in focal point inside the vacuum chamber. The focal point has 10 kilowatts of intense solar power. As part of MSFC's Space Transportation Directorate, the Propulsion Research Center serves as a national resource for research of advanced, revolutionary propulsion technologies. The mission is to move the Nation's capabilities beyond the confines of conventional chemical propulsion into an era of aircraft-like access to Earth-orbit, rapid travel throughout the solar system, and exploration of interstellar space.

Solar Thermal Propulsion Test Facility

NASA Technical Reports Server (NTRS)

1999-01-01

Researchers at the Marshall Space Flight Center (MSFC) have designed, fabricated and tested the first solar thermal engine, a non-chemical rocket engine that produces lower thrust but has better thrust efficiency than a chemical combustion engine. MSFC turned to solar thermal propulsion in the early 1990s due to its simplicity, safety, low cost, and commonality with other propulsion systems. Solar thermal propulsion works by acquiring and redirecting solar energy to heat a propellant. This photograph, taken at MSFC's Solar Thermal Propulsion Test Facility, shows a concentrator mirror, a combination of 144 mirrors forming this 18-ft diameter concentrator, and a vacuum chamber that houses the focal point. The 20- by 24-ft heliostat mirror (not shown in this photograph) has a dual-axis control that keeps a reflection of the sunlight on the 18-foot diameter concentrator mirror, which then focuses the sunlight to a 4-in focal point inside the vacuum chamber. The focal point has 10 kilowatts of intense solar power. As part of MSFC's Space Transportation Directorate, the Propulsion Research Center serves as a national resource for research of advanced, revolutionary propulsion technologies. The mission is to move the Nation's capabilities beyond the confines of conventional chemical propulsion into an era of aircraft-like access to Earth-orbit, rapid travel throughout the solar system, and exploration of interstellar space.

Design of Highly Articulated Mechanism for Surgical Applications

DTIC Science & Technology

2016-08-31

Army including surgery in the field and surgical bomb disarming. The views, opinions and/or findings contained in this report are those of the...many applications important to the Army including surgery in the field and surgical bomb disarming. We use minimally invasive surgery as a focal point...have many applications important to the Army including surgery in the field and surgical bomb disarming. We use minimally invasive surgery as a focal

Development of the focal plane system for the SEparator for CApture Reactions

NASA Astrophysics Data System (ADS)

Hood, A. A. D.; Blackmon, J. C.; Cottingham, R.; Deibel, C. M.; Good, E.; Joerres, K.; Laminack, A.; Garrity, A.; Secar Collaboration

2017-09-01

The SEparator for CApture Reactions (SECAR) is currently under construction for the National Superconducting Cyclotron Laboratory and future Facility for Rare Isotope Beams. SECAR is designed to conduct sensitive measurements of capture reactions critical to understanding stellar explosions. We have developed a versatile focal plane system that will differentiate reaction recoils from unreacted scattered beam particles in measurements covering a large range of energies and masses. The elements of the focal plane system include two metal-foil, micro-channel plate (MCP) detectors, a variety of diagnostics, and two alternative recoil stopping detectors. The MCP detectors will measure the time-of-flight (and therefore velocity) as well as the position of the recoils. Our primary heavy ion recoil detector is a gas ionization chamber that measures position, total energy and relative energy loss and provides good atomic number discrimination at energies greater than about 0.5 MeV/u. For some cases, this gas counter will be replaced by silicon strip detectors to provide superior energy resolution. We will describe the overall design and report on construction and testing of the detector systems. Supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, under Awards DE-SC0014384 and DE-FG02-96ER40978.

Gene genealogies for genetic association mapping, with application to Crohn's disease

PubMed Central

Burkett, Kelly M.; Greenwood, Celia M. T.; McNeney, Brad; Graham, Jinko

2013-01-01

A gene genealogy describes relationships among haplotypes sampled from a population. Knowledge of the gene genealogy for a set of haplotypes is useful for estimation of population genetic parameters and it also has potential application in finding disease-predisposing genetic variants. As the true gene genealogy is unknown, Markov chain Monte Carlo (MCMC) approaches have been used to sample genealogies conditional on data at multiple genetic markers. We previously implemented an MCMC algorithm to sample from an approximation to the distribution of the gene genealogy conditional on haplotype data. Our approach samples ancestral trees, recombination and mutation rates at a genomic focal point. In this work, we describe how our sampler can be used to find disease-predisposing genetic variants in samples of cases and controls. We use a tree-based association statistic that quantifies the degree to which case haplotypes are more closely related to each other around the focal point than control haplotypes, without relying on a disease model. As the ancestral tree is a latent variable, so is the tree-based association statistic. We show how the sampler can be used to estimate the posterior distribution of the latent test statistic and corresponding latent p-values, which together comprise a fuzzy p-value. We illustrate the approach on a publicly-available dataset from a study of Crohn's disease that consists of genotypes at multiple SNP markers in a small genomic region. We estimate the posterior distribution of the tree-based association statistic and the recombination rate at multiple focal points in the region. Reassuringly, the posterior mean recombination rates estimated at the different focal points are consistent with previously published estimates. The tree-based association approach finds multiple sub-regions where the case haplotypes are more genetically related than the control haplotypes, and that there may be one or multiple disease-predisposing loci. PMID:24348515

High-resolution velocimetry in energetic tidal currents using a convergent-beam acoustic Doppler profiler

NASA Astrophysics Data System (ADS)

Sellar, Brian; Harding, Samuel; Richmond, Marshall

2015-08-01

An array of single-beam acoustic Doppler profilers has been developed for the high resolution measurement of three-dimensional tidal flow velocities and subsequently tested in an energetic tidal site. This configuration has been developed to increase spatial resolution of velocity measurements in comparison to conventional acoustic Doppler profilers (ADPs) which characteristically use divergent acoustic beams emanating from a single instrument. This is achieved using geometrically convergent acoustic beams creating a sample volume at the focal point of 0.03 m3. Away from the focal point, the array is also able to simultaneously reconstruct three-dimensional velocity components in a profile throughout the water column, and is referred to herein as a convergent-beam acoustic Doppler profiler (C-ADP). Mid-depth profiling is achieved through integration of the sensor platform with the operational commercial-scale Alstom 1 MW DeepGen-IV Tidal Turbine deployed at the European Marine Energy Center, Orkney Isles, UK. This proof-of-concept paper outlines the C-ADP system configuration and comparison to measurements provided by co-installed reference instrumentation. Comparison of C-ADP to standard divergent ADP (D-ADP) velocity measurements reveals a mean difference of 8 mm s-1, standard deviation of 18 mm s-1, and an order of magnitude reduction in realisable length scale. C-ADP focal point measurements compared to a proximal single-beam reference show peak cross-correlation coefficient of 0.96 over 4.0 s averaging period and a 47% reduction in Doppler noise. The dual functionality of the C-ADP as a profiling instrument with a high resolution focal point make this configuration a unique and valuable advancement in underwater velocimetry enabling improved quantification of flow turbulence. Since waves are simultaneously measured via profiled velocities, pressure measurements and surface detection, it is expected that derivatives of this system will be a powerful tool in wave-current interaction studies.

Comparative feasibility study of two concepts for a space-based astrometric satellite

NASA Technical Reports Server (NTRS)

Bamdermann, L.; Bareket, N.; Metheny, W.

1982-01-01

A comparative feasibility study of two concepts for an astrometric satellite: a visual imaging telescope with a 16.5 meter focal length and a white light interferometer with a 15 meter baseline separation was conducted.

Methodological Aspects of Subjective Life Expectancy: Effects of Culture-Specific Reporting Heterogeneity Among Older Adults in the United States.

PubMed

Lee, Sunghee; Smith, Jacqui

2016-05-01

Subjective life expectancy (SLE) has been suggested as a predictor of mortality and mortality-related behaviors. Although critical for culturally diverse societies, these findings do not consider cross-cultural methodological comparability. Culture-specific reporting heterogeneity is a well-known phenomenon introducing biases, and research on this issue with SLE is not established. Using data from the Health and Retirement Study, we examined reporting heterogeneity in SLE focusing on item nonresponse, focal points, and reports over time for five ethnic-cultural groups: non-Hispanic Whites, non-Hispanic Blacks, non-Hispanic other races, English-interviewed Hispanics, and Spanish-interviewed Hispanics. On item nonresponse, Spanish-interviewed Hispanics said, "I don't know," to SLE significantly more than any other groups. Nearly half of the respondents chose 0, 50, or 100, making them focal points. However, the focal points differed: 50 for Whites, 100 for Blacks, and 0 for Spanish-interviewed Hispanics. The relationship of SLE measured at two time points was higher for Whites than minorities. Moreover, those who said "I don't know" to SLE showed higher subsequent mortality than those who gave an answer. SLE was not a significant mortality predictor for Hispanics. Overall, SLE is not free from culture-specific reporting heterogeneity. This warrants further research about its culture-relevant measurement mechanisms. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Role of third-order dispersion in chirped Airy pulse propagation in single-mode fibers

NASA Astrophysics Data System (ADS)

Cai, Wangyang; Wang, Lei; Wen, Shuangchun

2018-04-01

The dynamic propagation of the initial chirped Airy pulse in single-mode fibers is studied numerically, special attention being paid to the role of the third-order dispersion (TOD). It is shown that for the positive TOD, the Airy pulse experiences inversion irrespective of the sign of initial chirp. The role of TOD in the dynamic propagation of the initial chirped Airy pulse depends on the combined sign of the group-velocity dispersion (GVD) and the initial chirp. If the GVD and chirp have the opposite signs, the chirped Airy pulse compresses first and passes through a breakdown area, then reconstructs a new Airy pattern with opposite acceleration, with the breakdown area becoming small and the main peak of the new Airy pattern becoming asymmetric with an oscillatory structure due to the positive TOD. If the GVD and chirp have the same signs, the finite-energy Airy pulse compresses to a focal point and then inverses its acceleration, in the case of positive TOD, the distance to the focal point becoming smaller. At zero-dispersion point, the finite-energy Airy pulse inverses to the opposite acceleration at a focal point, with the tight-focusing effect being reduced by initial chirp. Under the effect of negative TOD, the initial chirped Airy pulse disperses and the lobes split. In addition, in the anomalous dispersion region, for strong nonlinearity, the initial chirped Airy pulse splits and enters a soliton shedding regime.

Basin boundaries and focal points in a map coming from Bairstow's method.

PubMed

Gardini, Laura; Bischi, Gian-Italo; Fournier-Prunaret, Daniele

1999-06-01

This paper is devoted to the study of the global dynamical properties of a two-dimensional noninvertible map, with a denominator which can vanish, obtained by applying Bairstow's method to a cubic polynomial. It is shown that the complicated structure of the basins of attraction of the fixed points is due to the existence of singularities such as sets of nondefinition, focal points, and prefocal curves, which are specific to maps with a vanishing denominator, and have been recently introduced in the literature. Some global bifurcations that change the qualitative structure of the basin boundaries, are explained in terms of contacts among these singularities. The techniques used in this paper put in evidence some new dynamic behaviors and bifurcations, which are peculiar of maps with denominator; hence they can be applied to the analysis of other classes of maps coming from iterative algorithms (based on Newton's method, or others). (c) 1999 American Institute of Physics.

Image motion compensation on the Spacelab 2 Solar Optical Universal Polarimeter /SL2 SOUP/

NASA Technical Reports Server (NTRS)

Tarbell, T. D.; Duncan, D. W.; Finch, M. L.; Spence, G.

1981-01-01

The SOUP experiment on Spacelab 2 includes a 30 cm visible light telescope and focal plane package mounted on the Instrument Pointing System (IPS). Scientific goals of the experiment dictate pointing stability requirements of less than 0.05 arcsecond jitter over periods of 5-20 seconds. Quantitative derivations of these requirements from two different aspects are presented: (1) avoidance of motion blurring of diffraction-limited images; (2) precise coalignment of consecutive frames to allow measurement of small image differences. To achieve this stability, a fine guider system capable of removing residual jitter of the IPS and image motions generated on the IPS cruciform instrument support structure has been constructed. This system uses solar limb detectors in the prime focal plane to derive an error signal. Image motion due to pointing errors is compensated by the agile secondary mirror mounted on piezoelectric transducers, controlled by a closed-loop servo system.

Bring the Pythagorean Theorem "Full Circle"

ERIC Educational Resources Information Center

Benson, Christine C.; Malm, Cheryl G.

2011-01-01

Middle school mathematics generally explores applications of the Pythagorean theorem and lays the foundation for working with linear equations. The Grade 8 Curriculum Focal Points recommend that students "apply the Pythagorean theorem to find distances between points in the Cartesian coordinate plane to measure lengths and analyze polygons and…

An HBCU Transformed

ERIC Educational Resources Information Center

Roach, Ronald

2006-01-01

Few institutions have embodied African-American history as completely as Wilberforce University. Established before the Civil War, the nation's oldest private Black college was a powerful focal point in the struggle for equality and served as a destination point on the Ohio Underground Railroad. Closed briefly during the Civil War, officials with…

Focal Adhesion-Independent Cell Migration.

PubMed

Paluch, Ewa K; Aspalter, Irene M; Sixt, Michael

2016-10-06

Cell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations have uncovered many of the molecular and physical mechanisms underlying cell migration. Together with protrusion extension and cell body retraction, adhesion to the substrate via specific focal adhesion points has long been considered an essential step in cell migration. Although this is true for cells moving on two-dimensional substrates, recent studies have demonstrated that focal adhesions are not required for cells moving in three dimensions, in which confinement is sufficient to maintain a cell in contact with its substrate. Here, we review the investigations that have led to challenging the requirement of specific adhesions for migration, discuss the physical mechanisms proposed for cell body translocation during focal adhesion-independent migration, and highlight the remaining open questions for the future.

Apparent diffusion coefficient of vertebral haemangiomas allows differentiation from malignant focal deposits in whole-body diffusion-weighted MRI.

PubMed

Winfield, Jessica M; Poillucci, Gabriele; Blackledge, Matthew D; Collins, David J; Shah, Vallari; Tunariu, Nina; Kaiser, Martin F; Messiou, Christina

2018-04-01

The aim of this study was to identify apparent diffusion coefficient (ADC) values for typical haemangiomas in the spine and to compare them with active malignant focal deposits. This was a retrospective single-institution study. Whole-body magnetic resonance imaging (MRI) scans of 106 successive patients with active multiple myeloma, metastatic prostate or breast cancer were analysed. ADC values of typical vertebral haemangiomas and malignant focal deposits were recorded. The ADC of haemangiomas (72 ROIs, median ADC 1,085×10 -6 mm 2 s -1 , interquartile range 927-1,295×10 -6 mm 2 s -1 ) was significantly higher than the ADC of malignant focal deposits (97 ROIs, median ADC 682×10 -6 mm 2 s -1 , interquartile range 583-781×10 -6 mm 2 s -1 ) with a p-value < 10 -6 . Receiver operating characteristic (ROC) analysis produced an area under the curve of 0.93. An ADC threshold of 872×10 -6 mm 2 s -1 separated haemangiomas from malignant focal deposits with a sensitivity of 84.7 % and specificity of 91.8 %. ADC values of classical vertebral haemangiomas are significantly higher than malignant focal deposits. The high ADC of vertebral haemangiomas allows them to be distinguished visually and quantitatively from active sites of disease, which show restricted diffusion. • Whole-body diffusion-weighted MRI is becoming widely used in myeloma and bone metastases. • ADC values of vertebral haemangiomas are significantly higher than malignant focal deposits. • High ADCs of haemangiomas allows them to be distinguished from active disease.

Breakdown simulations in a focused microwave beam within the simplified model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Semenov, V. E.; Rakova, E. I.; Glyavin, M. Yu.

2016-07-15

The simplified model is proposed to simulate numerically air breakdown in a focused microwave beam. The model is 1D from the mathematical point of view, but it takes into account the spatial non-uniformity of microwave field amplitude along the beam axis. The simulations are completed for different frequencies and different focal lengths of microwave beams. The results demonstrate complicated regimes of the breakdown evolution which represents a series of repeated ionization waves. These waves start at the focal point and propagate towards incident microwave radiation. The ionization wave parameters vary during propagation. At relatively low frequencies, the propagation regime ofmore » subsequent waves can also change qualitatively. Each next ionization wave is less pronounced than the previous one, and the breakdown evolution approaches the steady state with relatively small plasma density. The ionization wave parameters are sensitive to the weak source of external ionization, but the steady state is independent on such a source. As the beam focal length decreases, the stationary plasma density increases and the onset of the steady state occurs faster.« less

Solution for the nonuniformity correction of infrared focal plane arrays.

PubMed

Zhou, Huixin; Liu, Shangqian; Lai, Rui; Wang, Dabao; Cheng, Yubao

2005-05-20

Based on the S-curve model of the detector response of infrared focal plan arrays (IRFPAs), an improved two-point correction algorithm is presented. The algorithm first transforms the nonlinear image data into linear data and then uses the normal two-point algorithm to correct the linear data. The algorithm can effectively overcome the influence of nonlinearity of the detector's response, and it enlarges the correction precision and the dynamic range of the response. A real-time imaging-signal-processing system for IRFPAs that is based on a digital signal processor and field-programmable gate arrays is also presented. The nonuniformity correction capability of the presented solution is validated by experimental imaging procedures of a 128 x 128 pixel IRFPA camera prototype.

On a focal point instability in (B3Πg - C3Πu)N2 optogalvanic circuit with hollow cathode

NASA Astrophysics Data System (ADS)

Gencheva, V.

2016-03-01

The (B3Πg, v = 0 - C3 Πu, v = 0) N2 dynamic optogalvanic signals have been registered illuminating an Al hollow cathode lamp with a pulsed N2 laser generating at the wavelength of 337.1nm. The dynamic optogalvanic signal (DOGS) at certain discharge current of 8 mA is a harmonic oscillator due to a focal point instability produced by our optogalvanic circuit. This damped harmonic oscillator can be described as a solution of linear second order homogeneous differential equation. The oscillation frequency is estimated from the registered DOGS using Fourier synthesis. The analytical description of the damped harmonic DOGS is obtained.

Low cost point focus solar concentrator, phase 1

NASA Technical Reports Server (NTRS)

1979-01-01

Design concepts and plans for mass-production facilities and equipment, field installation, and maintenance were developed and used for cost analysis of a pneumatically stabilized plastic film point focus solar concentrator which has potential application in conjunction with Brayton cycle engines or supply of thermal energy. A sub-scale reflector was fabricated and optically tested by laser ray tracing to determine focal deviations of the surface slope and best focal plane. These test data were then used for comparisons with theoretical concentrator performance modeling and predictions of full-scale design performance. Results of the economic study indicate the concentrator design will have low cost when mass-produced and has cost/performance parameters that fall within current Jet Propulsion Laboratory goals.

Microscopy with multimode fibers

NASA Astrophysics Data System (ADS)

Moser, Christophe; Papadopoulos, Ioannis; Farahi, Salma; Psaltis, Demetri

2013-04-01

Microscopes are usually thought of comprising imaging elements such as objectives and eye-piece lenses. A different type of microscope, used for endoscopy, consists of waveguiding elements such as fiber bundles, where each fiber in the bundle transports the light corresponding to one pixel in the image. Recently a new type of microscope has emerged that exploits the large number of propagating modes in a single multimode fiber. We have successfully produced fluorescence images of neural cells with sub-micrometer resolution via a 200 micrometer core multimode fiber. The method for achieving imaging consists of using digital phase conjugation to reproduce a focal spot at the tip of the multimode fiber. The image is formed by scanning the focal spot digitally and collecting the fluorescence point by point.

An alignment method for mammographic X-ray spectroscopy under clinical conditions.

PubMed

Miyajima, S; Imagawa, K; Matsumoto, M

2002-09-01

This paper describes an alignment method for mammographic X-ray spectroscopy under clinical conditions. A pinhole, a fluorescent screen, a laser device and the case for a detector are used for alignment of the focal spot, a collimator and a detector. The method determines the line between the focal spot and the point of interest in an X-ray field radiographically. The method allows alignment for both central axis and off-axis directions.

Non-invasive identification of stable rotors and focal sources for human atrial fibrillation: mechanistic classification of atrial fibrillation from the electrocardiogram.

PubMed

Jones, Aled R; Krummen, David E; Narayan, Sanjiv M

2013-09-01

To develop electrocardiogram (ECG) tools to quantify the number of sources for atrial fibrillation (AF), i.e. spatially stable rotors and focal impulses, and whether they lie in right or left atrium. Intracardiac mapping has recently shown that paroxysmal and persistent AF is sustained by rotors or focal sources that are stable in location and thus targets for limited ablation [focal impulse and rotor modulation (FIRM)] to eliminate AF. Importantly, the numbers and locations of concurrent sources determine both the complexity of AF and the approach for ablation. In 36 AF patients (n = 29 persistent, 63 ± 9 years) in the CONventional ablation with or without Focal Impulse and Rotor Modulation (CONFIRM) trial, we developed phase lock (PL) to quantify spatial repeatability of ECG 'F-waves' between leads over time. Phase lock spectrally quantifies the angle θ between F-wave voltages in planes formed by ECG leads I, aVF, and V1 at successive points in time. We compared PL with ECG spectral dominant frequency (DF) and organizational index (OI) to characterize stable rotors and focal sources validated by intracardiac FIRM mapping. Focal impulse and rotor modulation ablation alone at ≤3 sources acutely terminated and rendered AF non-inducible or substantially slowed AF in 31 of 36 patients. Receiver operating characteristics of PL for this endpoint had area under the curve (AUC) = 0.72, and the optimum cut-point (PL = 0.09) had 74% sensitivity, 92% positive predictive value (PPV). Receiver operating characteristics areas for OI and DF were 0.50 and 0.58, respectively. Left (n = 28) or right (n = 3) atrial sources were localized by PL with AUC = 0.85, sensitivity 100%, PPV 30%, and negative predictive value 100%. Spectral DF provided AUC = 0.79. Notably, PL did not comigrate with diagnosis of paroxysmal or persistent AF (P = NS), unlike ECG DF. The novel metric of ECG PL identifies patients with fewer (≤3) or greater numbers of stable rotors/focal sources for AF, validated by intracardiac FIRM mapping, and localized them to right or left atria. These data open the possibility of using 12-lead ECG analyses to classify AF mechanistically and plan procedures for right- or left-sided FIRM ablation.

Phase-shift nano-emulsions induced cavitation and ablation during high intensity focused ultrasound exposure

NASA Astrophysics Data System (ADS)

Qiao, Yangzi; Yin, Hui; Chang, Nan; Wan, Mingxi

2017-03-01

Phase-shift Nano-emulsions (PSNEs) with a small initial diameter in nanoscale have the potential to leak out of the blood vessels and to accumulate at target point of tissue. At desired location, PSNEs can undergo acoustic droplet vaporization (ADV) process, change into gas bubbles and enhance focused ultrasound efficiency. The aim of this work was to provide spatial and temporal information on PSNE induced cavitation and ablation effects during pulsed high intensity focused ultrasound (HIFU) exposure. The PSNEs were composed of perfluorohaxane (PFH) and bovine serum albumin (BSA), and then uniformly distributed in a transparent polyacrylamide phantom. The Sonoluminescence (SL) method was employed to visualize the cavitation distribution and formation process of PSNEs induced cavitation. For the phantom which was used for ablation observation, heat sensitive BSA was added. When the temperature generated by ultrasound exposure was high enough to denature BSA, the transparent phantom would turn out white lesions. The shape of the lesion and the formation process were compared with those of cavitation. Each of the pulse contained 12 cycles for a duration of 10 µs. And the duty cycle changed from 1:10 to 1:40. The total "on" time of HIFU was 2s. PSNE can evidently accelerate cavitation emitting bright SL in pre-focal region. The cavitation was generated layer by layer towards the transducer. The formed bubble wall can block acoustic waves transmitting to the distal end. And the lesion appeared to be separated into two parts. One in pre-focal region stemmed from one point and grew quickly toward the transducer. The other in focal region was formed by merging some small white dots, and grew much slower. The influence of duty cycle has also been examined. The lower duty cycle with longer pulse-off time would generate more intense cavitation, however, smaller lesion. Bubble cloud gradually developed within phantom would greatly influence the cavitation and ablation process. One hand, the evaporated bubbles could enhance both the cavitation and thermal effects of HIFU. The other hand, outside layer bubbles would block the acoustic wave transmission, inducing distinctive cavitation and ablation formation process. The spatial distribution of cavitation and lesion organized into special structures under different acoustic parameters.

Coagulation and ablation patterns of high-intensity focused ultrasound on a tissue-mimicking phantom and cadaveric skin.

PubMed

Kim, Hee-Jin; Kim, Han Gu; Zheng, Zhenlong; Park, Hyoun Jun; Yoon, Jeung Hyun; Oh, Wook; Lee, Cheol Woo; Cho, Sung Bin

2015-12-01

High-intensity focused ultrasound (HIFU) can be applied noninvasively to create focused zones of tissue coagulation on various skin layers. We performed a comparative study of HIFU, evaluating patterns of focused tissue coagulation and ablation upon application thereof. A tissue-mimicking (TM) phantom was prepared with bovine serum albumin and polyacrylamide hydrogel to evaluate the geometric patterns of HIFU-induced thermal injury zones (TIZs) for five different HIFU devices. Additionally, for each device, we investigated histologic patterns of HIFU-induced coagulation and ablation in serial sections of cadaveric skin of the face and neck. All HIFU devices generated remarkable TIZs in the TM phantom, with different geometric values of coagulation for each device. Most of the TIZs seemed to be separated into two or more tiny parts. In cadaveric skin, characteristic patterns of HIFU-induced ablation and coagulation were noted along the mid to lower dermis at the focal penetration depth of 3 mm and along subcutaneous fat to the superficial musculoaponeurotic system or the platysma muscle of the neck at 4.5 mm. Additionally, remarkable pre-focal areas of tissue coagulation were observed in the upper and mid dermis at the focal penetration depth of 3 mm and mid to lower dermis at 4.5 mm. For five HIFU devices, we outlined various patterns of HIFU-induced TIZ formation along pre-focal, focal, and post-focal areas of TM phantom and cadaveric skin of the face and neck.

Be Mindful of What You Impose on Your Colleagues: Implications of Social Burden for Burdenees' Well-being, Attitudes and Counterproductive Work Behaviour.

PubMed

Yang, Liu-Qin; Liu, Cong; Nauta, Margaret M; Caughlin, David E; Spector, Paul E

2016-02-01

This paper describes two studies of a new relational variable social burden and its implications for employees' well-being, job attitudes and counterproductive work behaviours. Social burden is defined as behaviours from colleagues that elicit the focal employees' social support. Across two separate samples (540 nurses and 172 university employees), we found that social burden differentiated from psychological aggression and incivility, respectively. A separate cross-sectional sample of 273 nurses from Study 1 revealed that social burden from colleagues was positively associated with focal employees' anxiety, irritation, depressive mood, physical symptoms, job dissatisfaction and turnover intentions. Study 2 used a time-lagged design with a separate sample of 383 university employees and 160 of their coworkers. In this study, social burden from supervisors and from coworkers were together predictive of employees' subsequent emotional strains and job attitudes, as measured 6 months later. With respect to sources of social burden, social burden from supervisors more strongly predicted job attitudes and counterproductive work behaviours directed at others, and social burden from coworkers more strongly predicted emotional strains. Copyright © 2014 John Wiley & Sons, Ltd.

[Expected effect of retinal thickness after focal photocoagulation in diabetic macular oedema].

PubMed

Garcia-Rubio, Yatzul Zuhaila; Razo Blanco-Hernández, Dulce Milagros; Lima-Gómez, Virgilio

2016-01-01

Macular oedema is a form of diabetic retinopathy that can be treated with photocoagulation. The expected effect of treatment varies, and may depend on the previous characteristics of retinal thickening. To determine whether the change in retinal thickness after focal photocoagulation for diabetic macular oedema varies due to the presence of anatomical features that may justify a separate assessment. Non-experimental, comparative, retrospective, longitudinal study. The mean percentage change in macular volume was compared in eyes with diabetic macular oedema, 3 weeks after focal photocoagulation. The analysis was stratified according to the presence of central and perifoveal temporal thickening (Mann-Whitney U). A regression analysis was performed to identify the contribution of the anatomical variables before photocoagulation to the change in macular volume. A total of 72 eyes were evaluated. The mean change of macular volume in the sample was -0.68±3.84%. In the multiple regression analysis, the changes of perifoveal temporal (beta 0.54, p<0.001) and central field thickness (beta 0.3, p =0.01) contributed to the change of macular volume (R=0.64). Macular volume decreased by a mean of -2.1±4.3% in eyes with temporal perifoveal thickening, and increased by 0.5±2.8% (p =0.007) in eyes with no thickening. Perifoveal temporal thickening before photocoagulation changes the expected effect of this therapy on macular volume in eyes with focal diabetic macular oedema. It is recommended to evaluate the effect separately, and according to the perifoveal temporal thickness. Copyright © 2015 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.

Enhanced cryopreservation of MSCs in microfluidic bioreactor by regulated shear flow

PubMed Central

Bissoyi, Akalabya; Bit, Arindam; Singh, Bikesh Kumar; Singh, Abhishek Kumar; Patra, Pradeep Kumar

2016-01-01

Cell-matrix systems can be stored for longer period of time by means of cryopreservation. Cell-matrix and cell-cell interaction has been found to be critical in a number of basic biological processes. Tissue structure maintenance, cell secretary activity, cellular migration, and cell-cell communication all exist because of the presence of cell interactions. This complex and co-ordinated interaction between cellular constituents, extracellular matrix and adjacent cells has been identified as a significant contributor in the overall co-ordination of tissue. The prime objective of this investigation is to evaluate the effects of shear-stress and cell-substrate interaction in successful recovery of adherent human mesenchymal-stem-cells (hMSCs). A customized microfluidic bioreactor has been used for the purpose. We have measured the changes in focal-point-adhesion (FPAs) by changing induced shear stress inside the bioreactor. The findings indicate that with increase in shear stress, FPAs increases between substrate and MSCs. Further, experimental results show that increased FPAs (4e-3 μbar) enhances the cellular survivability of adherent MSCs. Probably, for the first time involvement of focal point interaction in the outcome of cryopreservation of MSCs has been clarified, and it proved a potentially new approach for modification of cryopreservation protocol by up-regulating focal point of cells to improve its clinical application. PMID:27748463

Real-time method for motion-compensated MR thermometry and MRgHIFU treatment in abdominal organs.

PubMed

Celicanin, Zarko; Auboiroux, Vincent; Bieri, Oliver; Petrusca, Lorena; Santini, Francesco; Viallon, Magalie; Scheffler, Klaus; Salomir, Rares

2014-10-01

Magnetic resonance-guided high-intensity focused ultrasound is considered to be a promising treatment for localized cancer in abdominal organs such as liver, pancreas, or kidney. Abdominal motion, anatomical arrangement, and required sustained sonication are the main challenges. MR acquisition consisted of thermometry performed with segmented gradient-recalled echo echo-planar imaging, and a segment-based one-dimensional MR navigator parallel to the main axis of motion to track the organ motion. This tracking information was used in real-time for: (i) prospective motion correction of MR thermometry and (ii) HIFU focal point position lock-on target. Ex vivo experiments were performed on a sheep liver and a turkey pectoral muscle using a motion demonstrator, while in vivo experiments were conducted on two sheep liver. Prospective motion correction of MR thermometry yielded good signal-to-noise ratio (range, 25 to 35) and low geometric distortion due to the use of segmented EPI. HIFU focal point lock-on target yielded isotropic in-plane thermal build-up. The feasibility of in vivo intercostal liver treatment was demonstrated in sheep. The presented method demonstrated in moving phantoms and breathing sheep accurate motion-compensated MR thermometry and precise HIFU focal point lock-on target using only real-time pencil-beam navigator tracking information, making it applicable without any pretreatment data acquisition or organ motion modeling. Copyright © 2013 Wiley Periodicals, Inc.

High intensity focused ultrasound (HIFU) focal spot localization using harmonic motion imaging (HMI).

PubMed

Han, Yang; Hou, Gary Yi; Wang, Shutao; Konofagou, Elisa

2015-08-07

Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of high-intensity focused ultrasound (HIFU) treatment. However, accurate localization and characterization of the effective region of treatment (focal spot) remain important obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a HIFU monitoring technique that utilizes radiation-force-induced localized oscillatory displacement. HMIFU has been shown to correctly identify the formation and extent of HIFU thermal ablation lesions. However a significant problem remains in identifying the location of the HIFU focus, which is necessary for treatment planning. In this study, the induced displacement was employed to localize the HIFU focal spot inside the tissue prior to treatment. Feasibility was shown with two separate systems. The 1D HMIFU system consisted of a HIFU transducer emitting an amplitude-modulated HIFU beam for mechanical excitation and a confocal single-element, pulse-echo transducer for simultaneous RF acquisition. The 2D HIFU system consists of a HIFU phased array, and a co-axial imaging phased array for simultaneous imaging. Initial feasibility was first performed on tissue-mimicking gelatin phantoms and the focal zone was defined as the region corresponding to the -3dB full width at half maximum of the HMI displacement. Using the same parameters, in vitro experiments were performed in canine liver specimens to compare the defined focal zone with the lesion. In vitro measurements showed good agreement between the HMI predicted focal zone and the induced HIFU lesion location. HMIFU was experimentally shown to be capable of predicting and tracking the focal region in both phantoms and in vitro tissues. The accuracy of focal spot localization was evaluated by comparing with the lesion location in post-ablative tissues, with a R(2) = 0.821 at p < 0.002 in the 2D HMI system. We demonstrated the feasibility of using this HMI-based technique to localize the HIFU focal spot without inducing thermal changes during the planning phase. The focal spot localization method has also been applied on ex vivo human breast tissue ablation and can be fully integrated into any HMI system for planning purposes.

High Intensity Focused Ultrasound (HIFU) Focal Spot Localization Using Harmonic Motion Imaging (HMI)

PubMed Central

Han, Yang; Hou, Gary Yi; Wang, Shutao; Konofagou, Elisa

2015-01-01

Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of High-Intensity Focused Ultrasound (HIFU) treatment. However, accurate localization and characterization of the effective region of treatment (focal spot) remain important obstacles in the clinical implementation of HIFU ablation. Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a HIFU monitoring technique that utilizes radiation-force-induced localized oscillatory displacement. HMIFU has been shown to correctly identify the formation and extent of HIFU thermal ablation lesions. However a significant problem remains in identifying the location of the HIFU focus, which is necessary for treatment planning. In this study, the induced displacement was employed to localize the HIFU focal spot inside the tissue prior to treatment. Feasibility was shown with two separate systems. The 1D HMIFU system consisted of a HIFU transducer emitting an amplitude-modulated HIFU beam for mechanical excitation and a confocal single-element, pulse-echo transducer for simultaneous RF acquisition. The 2D HIFU system consists of a HIFU phased array, and a co-axial imaging phased array for simultaneous imaging. Initial feasibility was first performed on tissue-mimicking gelatin phantoms and the focal zone was defined as the region corresponding to the −3 dB full width at half maximum of the HMI displacement. Using the same parameters, in vitro experiments were performed in canine liver specimens to compare the defined focal zone with the lesion. In vitro measurements showed good agreement between the HMI predicted focal zone and the induced HIFU lesion location. HMIFU was experimentally shown to be capable of predicting and tracking the focal region in both phantoms and in vitro tissues. The accuracy of focal spot localization was evaluated by comparing with the lesion location in post-ablative tissues, with a R2 = 0.821 at p<0.002 in the 2D HMI system. We demonstrated the feasibility of using this HMI-based technique to localize the HIFU focal spot without inducing thermal changes during the planning phase. The focal spot localization method has also been applied on ex vivo human breast tissue ablation and can be fully integrated into any HMI system for planning purposes. PMID:26184846

High intensity focused ultrasound (HIFU) focal spot localization using harmonic motion imaging (HMI)

NASA Astrophysics Data System (ADS)

Han, Yang; Hou, Gary Yi; Wang, Shutao; Konofagou, Elisa

2015-08-01

Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of high-intensity focused ultrasound (HIFU) treatment. However, accurate localization and characterization of the effective region of treatment (focal spot) remain important obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a HIFU monitoring technique that utilizes radiation-force-induced localized oscillatory displacement. HMIFU has been shown to correctly identify the formation and extent of HIFU thermal ablation lesions. However a significant problem remains in identifying the location of the HIFU focus, which is necessary for treatment planning. In this study, the induced displacement was employed to localize the HIFU focal spot inside the tissue prior to treatment. Feasibility was shown with two separate systems. The 1D HMIFU system consisted of a HIFU transducer emitting an amplitude-modulated HIFU beam for mechanical excitation and a confocal single-element, pulse-echo transducer for simultaneous RF acquisition. The 2D HIFU system consists of a HIFU phased array, and a co-axial imaging phased array for simultaneous imaging. Initial feasibility was first performed on tissue-mimicking gelatin phantoms and the focal zone was defined as the region corresponding to the  -3dB full width at half maximum of the HMI displacement. Using the same parameters, in vitro experiments were performed in canine liver specimens to compare the defined focal zone with the lesion. In vitro measurements showed good agreement between the HMI predicted focal zone and the induced HIFU lesion location. HMIFU was experimentally shown to be capable of predicting and tracking the focal region in both phantoms and in vitro tissues. The accuracy of focal spot localization was evaluated by comparing with the lesion location in post-ablative tissues, with a R2 = 0.821 at p  <  0.002 in the 2D HMI system. We demonstrated the feasibility of using this HMI-based technique to localize the HIFU focal spot without inducing thermal changes during the planning phase. The focal spot localization method has also been applied on ex vivo human breast tissue ablation and can be fully integrated into any HMI system for planning purposes.

7 CFR 3800.3 - Functions.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... (c) Weather and climate. (1) Serve as a focal point within the Department for coordination of weather, climate, and related crop monitoring activities. (d) Remote sensing. (1) Provide technical assistance...

7 CFR 3800.3 - Functions.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... (c) Weather and climate. (1) Serve as a focal point within the Department for coordination of weather, climate, and related crop monitoring activities. (d) Remote sensing. (1) Provide technical assistance...

7 CFR 3800.3 - Functions.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... (c) Weather and climate. (1) Serve as a focal point within the Department for coordination of weather, climate, and related crop monitoring activities. (d) Remote sensing. (1) Provide technical assistance...

7 CFR 3800.3 - Functions.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... (c) Weather and climate. (1) Serve as a focal point within the Department for coordination of weather, climate, and related crop monitoring activities. (d) Remote sensing. (1) Provide technical assistance...

Homogeneity of Moral Judgment? Apprentices Solving Business Conflicts.

ERIC Educational Resources Information Center

Beck, Klaus; Heinrichs, Karin; Minnameier, Gerhard; Parche-Kawik, Kirsten

In an ongoing longitudinal study that started in 1994, the moral development of business apprentices is being studied. The focal point of this project is a critical analysis of L. Kohlberg's thesis of homogeneity, according to which people should judge every moral issue from the point of view of their "modal" stage (the most frequently…

Separation efficiency of the MASHA facility for short-lived mercury isotopes

NASA Astrophysics Data System (ADS)

Rodin, A. M.; Belozerov, A. V.; Chernysheva, E. V.; Dmitriev, S. N.; Gulyaev, A. V.; Gulyaeva, A. V.; Itkis, M. G.; Kliman, J.; Kondratiev, N. A.; Krupa, L.; Novoselov, A. S.; Oganessian, Yu. Ts.; Podshibyakin, A. V.; Salamatin, V. S.; Siváček, I.; Stepantsov, S. V.; Vanin, D. V.; Vedeneev, V. Yu.; Yukhimchuk, S. A.; Granja, C.; Pospisil, S.

2014-06-01

The mass-separator MASHA built to identify Super Heavy Elements by their mass-to-charge ratios is described. The results of the off- and on-line measurements of its separation efficiency are presented. In the former case four calibrated leaks of noble gases were used. In the latter the efficiency was measured via 284 MeV Ar beam and with using the hot catcher. The ECR ion source was used in both cases. The -radioactive isotopes of mercury produced in the complete fusion reaction Ar+SmHg+xn were detected at the mass-separator focal plane. The half-lives and the separation efficiency for the short-lived mercury isotopes were measured. Potentialities of the MEDIPIX detector system have been demonstrated for future use at the mass-separator MASHA.

Emergency Operations Center

EPA Pesticide Factsheets

EOC serves as the response operational focal point. A communication and coordination hub designed to increase data management and coordination abilities, provides communication support for Watch Officer, Homeland Security, regional and field assets.

Target isolation system, high power laser and laser peening method and system using same

DOEpatents

Dane, C. Brent; Hackel, Lloyd A.; Harris, Fritz

2007-11-06

A system for applying a laser beam to work pieces, includes a laser system producing a high power output beam. Target delivery optics are arranged to deliver the output beam to a target work piece. A relay telescope having a telescope focal point is placed in the beam path between the laser system and the target delivery optics. The relay telescope relays an image between an image location near the output of the laser system and an image location near the target delivery optics. A baffle is placed at the telescope focal point between the target delivery optics and the laser system to block reflections from the target in the target delivery optics from returning to the laser system and causing damage.

Apparatus for and method of performing spectroscopic analysis on an article

DOEpatents

Powell, George Louis; Hallman, Jr., Russell Louis

1999-01-01

An apparatus for and method of analyzing an article having an entrance and an exit in communication with the entrance. The apparatus comprises: a spectrometer having an emission source with a focal point; a plurality of mirrors; and a detector connected to the spectroscope. The emission source is positioned so that its focal point is substantially coextensive with the entrance of the article. The mirrors comprise: a first mirror positionable adjacent the exit of the article and a second mirror positioned relative to the other of said plurality of mirrors. The first mirror receives scattered emissions exiting the article and substantially collimates the scattered emissions. The second mirror substantially focuses the collimated emissions into a focused emission. The detector receives the focused emission from the mirrors.

Apparatus for and method of performing spectroscopic analysis on an article

DOEpatents

Powell, G.L.; Hallman, R.L. Jr.

1999-04-20

An apparatus and method are disclosed for analyzing an article having an entrance and an exit in communication with the entrance. The apparatus comprises: a spectrometer having an emission source with a focal point; a plurality of mirrors; and a detector connected to the spectroscope. The emission source is positioned so that its focal point is substantially coextensive with the entrance of the article. The mirrors comprise: a first mirror positionable adjacent the exit of the article and a second mirror positioned relative to the other of said plurality of mirrors. The first mirror receives scattered emissions exiting the article and substantially collimates the scattered emissions. The second mirror substantially focuses the collimated emissions into a focused emission. The detector receives the focused emission from the mirrors. 6 figs.

Gas chromatography/matrix-isolation apparatus

DOEpatents

Reedy, G.T.

1986-06-10

A gas-sample collection device provides matrix isolation of individual gas bands from a gas chromatographic separation and for the spectroscopic analysis of the individual sample bands. The device includes a vacuum chamber containing a rotatably supported, specular carousel having at least one reflecting surface for holding a sample deposited thereon. A gas inlet is provided for depositing a mixture of sample and matrix material on the reflecting surface which is maintained at a sufficiently low temperature to cause solidification. A first parabolic mirror directs an incident beam of electromagnetic radiation, such as in the infrared (IR) spectrum, from a source onto the sample/matrix mixture while a second parabolic mirror directs a second beam of electromagnetic radiation reflected by the specular surface to an IR spectrometer for determining the absorption spectra of the sample material deposited on the reflecting surface. The pair of off-axis parabolic mirrors having a common focal point are positioned outside of the vacuum chamber and may be displaced in combination for improved beam positioning and alignment. The carousel is provided with an aperture for each reflecting surface to facilitate accurate positioning of the incident beam relative to the gas-samples under analysis. Improved gas-sample deposition is insured by the use of a long focal length stereomicroscope positioned outside of the vacuum chamber for monitoring sample formation through a window, while the sample collector is positioned outside of the zone bounded by the incident and reflected electromagnetic beams for improved sample access and monitoring. 10 figs.

Gas chromatography/matrix-isolation apparatus

DOEpatents

Reedy, Gerald T.

1986-01-01

A gas-sample collection device provides matrix isolation of individual gas bands from a gas chromatographic separation and for the spectroscopic analysis of the individual sample bands. The device includes a vacuum chamber containing a rotatably supported, specular carousel having at least one reflecting surface for holding a sample deposited thereon. A gas inlet is provided for depositing a mixture of sample and matrix material on the reflecting surface which is maintained at a sufficiently low temperature to cause solidification. A first parabolic mirror directs an incident beam of electromagnetic radiation, such as in the infrared (IR) spectrum, from a source onto the sample/matrix mixture while a second parabolic mirror directs a second beam of electromagnetic radiation reflected by the specular surface to an IR spectrometer for determining the absorption spectra of the sample material deposited on the reflecting surface. The pair of off-axis parabolic mirrors having a common focal point are positioned outside of the vacuum chamber and may be displaced in combination for improved beam positioning and alignment. The carousel is provided with an aperture for each reflecting surface to facilitate accurate positioning of the incident beam relative to the gas-samples under analysis. Improved gas-sample deposition is insured by the use of a long focal length stereomicroscope positioned outside of the vacuum chamber for monitoring sample formation through a window, while the sample collector is positioned outside of the zone bounded by the incident and reflected electromagnetic beams for improved sample access and monitoring.

HYMOSS signal processing for pushbroom spectral imaging

NASA Technical Reports Server (NTRS)

Ludwig, David E.

1991-01-01

The objective of the Pushbroom Spectral Imaging Program was to develop on-focal plane electronics which compensate for detector array non-uniformities. The approach taken was to implement a simple two point calibration algorithm on focal plane which allows for offset and linear gain correction. The key on focal plane features which made this technique feasible was the use of a high quality transimpedance amplifier (TIA) and an analog-to-digital converter for each detector channel. Gain compensation is accomplished by varying the feedback capacitance of the integrate and dump TIA. Offset correction is performed by storing offsets in a special on focal plane offset register and digitally subtracting the offsets from the readout data during the multiplexing operation. A custom integrated circuit was designed, fabricated, and tested on this program which proved that nonuniformity compensated, analog-to-digital converting circuits may be used to read out infrared detectors. Irvine Sensors Corporation (ISC) successfully demonstrated the following innovative on-focal-plane functions that allow for correction of detector non-uniformities. Most of the circuit functions demonstrated on this program are finding their way onto future IC's because of their impact on reduced downstream processing, increased focal plane performance, simplified focal plane control, reduced number of dewar connections, as well as the noise immunity of a digital interface dewar. The potential commercial applications for this integrated circuit are primarily in imaging systems. These imaging systems may be used for: security monitoring systems, manufacturing process monitoring, robotics, and for spectral imaging when used in analytical instrumentation.

HYMOSS signal processing for pushbroom spectral imaging

NASA Astrophysics Data System (ADS)

Ludwig, David E.

1991-06-01

The objective of the Pushbroom Spectral Imaging Program was to develop on-focal plane electronics which compensate for detector array non-uniformities. The approach taken was to implement a simple two point calibration algorithm on focal plane which allows for offset and linear gain correction. The key on focal plane features which made this technique feasible was the use of a high quality transimpedance amplifier (TIA) and an analog-to-digital converter for each detector channel. Gain compensation is accomplished by varying the feedback capacitance of the integrate and dump TIA. Offset correction is performed by storing offsets in a special on focal plane offset register and digitally subtracting the offsets from the readout data during the multiplexing operation. A custom integrated circuit was designed, fabricated, and tested on this program which proved that nonuniformity compensated, analog-to-digital converting circuits may be used to read out infrared detectors. Irvine Sensors Corporation (ISC) successfully demonstrated the following innovative on-focal-plane functions that allow for correction of detector non-uniformities. Most of the circuit functions demonstrated on this program are finding their way onto future IC's because of their impact on reduced downstream processing, increased focal plane performance, simplified focal plane control, reduced number of dewar connections, as well as the noise immunity of a digital interface dewar. The potential commercial applications for this integrated circuit are primarily in imaging systems. These imaging systems may be used for: security monitoring systems, manufacturing process monitoring, robotics, and for spectral imaging when used in analytical instrumentation.

Double peacock eye optical element for extended focal depth imaging with ophthalmic applications.

PubMed

Romero, Lenny A; Millán, María S; Jaroszewicz, Zbigniew; Kolodziejczyk, Andrzej

2012-04-01

The aged human eye is commonly affected by presbyopia, and therefore, it gradually loses its capability to form images of objects placed at different distances. Extended depth of focus (EDOF) imaging elements can overcome this inability, despite the introduction of a certain amount of aberration. This paper evaluates the EDOF imaging performance of the so-called peacock eye phase diffractive element, which focuses an incident plane wave into a segment of the optical axis and explores the element's potential use for ophthalmic presbyopia compensation optics. Two designs of the element are analyzed: the single peacock eye, which produces one focal segment along the axis, and the double peacock eye, which is a spatially multiplexed element that produces two focal segments with partial overlapping along the axis. The performances of the peacock eye elements are compared with those of multifocal lenses through numerical simulations as well as optical experiments in the image space. The results demonstrate that the peacock eye elements form sharper images along the focal segment than the multifocal lenses and, therefore, are more suitable for presbyopia compensation. The extreme points of the depth of field in the object space, which represent the remote and the near object points, have been experimentally obtained for both the single and the double peacock eye optical elements. The double peacock eye element has better imaging quality for relatively short and intermediate distances than the single peacock eye, whereas the latter seems better for far distance vision.

SIRTF Focal Plane Survey: A Pre-flight Error Analysis

NASA Technical Reports Server (NTRS)

Bayard, David S.; Brugarolas, Paul B.; Boussalis, Dhemetrios; Kang, Bryan H.

2003-01-01

This report contains a pre-flight error analysis of the calibration accuracies expected from implementing the currently planned SIRTF focal plane survey strategy. The main purpose of this study is to verify that the planned strategy will meet focal plane survey calibration requirements (as put forth in the SIRTF IOC-SV Mission Plan [4]), and to quantify the actual accuracies expected. The error analysis was performed by running the Instrument Pointing Frame (IPF) Kalman filter on a complete set of simulated IOC-SV survey data, and studying the resulting propagated covariances. The main conclusion of this study is that the all focal plane calibration requirements can be met with the currently planned survey strategy. The associated margins range from 3 to 95 percent, and tend to be smallest for frames having a 0.14" requirement, and largest for frames having a more generous 0.28" (or larger) requirement. The smallest margin of 3 percent is associated with the IRAC 3.6 and 5.8 micron array centers (frames 068 and 069), and the largest margin of 95 percent is associated with the MIPS 160 micron array center (frame 087). For pointing purposes, the most critical calibrations are for the IRS Peakup sweet spots and short wavelength slit centers (frames 019, 023, 052, 028, 034). Results show that these frames are meeting their 0.14" requirements with an expected accuracy of approximately 0.1", which corresponds to a 28 percent margin.

Focal Point Theory Models for Dissecting Dynamic Duality Problems of Microbial Infections

PubMed Central

Huang, S.-H.; Zhou, W.; Jong, A.

2008-01-01

Extending along the dynamic continuum from conflict to cooperation, microbial infections always involve symbiosis (Sym) and pathogenesis (Pat). There exists a dynamic Sym-Pat duality (DSPD) in microbial infection that is the most fundamental problem in infectomics. DSPD is encoded by the genomes of both the microbes and their hosts. Three focal point (FP) theory-based game models (pure cooperative, dilemma, and pure conflict) are proposed for resolving those problems. Our health is associated with the dynamic interactions of three microbial communities (nonpathogenic microbiota (NP) (Cooperation), conditional pathogens (CP) (Dilemma), and unconditional pathogens (UP) (Conflict)) with the hosts at different health statuses. Sym and Pat can be quantitated by measuring symbiotic index (SI), which is quantitative fitness for the symbiotic partnership, and pathogenic index (PI), which is quantitative damage to the symbiotic partnership, respectively. Symbiotic point (SP), which bears analogy to FP, is a function of SI and PI. SP-converting and specific pathogen-targeting strategies can be used for the rational control of microbial infections. PMID:18350122

Quiet is the new loud: pausing and focus in child and adult Dutch.

PubMed

Romøren, Anna Sara H; Chen, Aoju

2015-03-01

In a number of languages, prosody is used to highlight new information (or focus). In Dutch, focus is marked by accentuation, whereby focal constituents are accented and post-focal constituents are de-accented. Even if pausing is not traditionally seen as a cue to focus in Dutch, several previous studies have pointed to a possible relationship between pausing and information structure. Considering that Dutch-speaking 4 to 5 year olds are not yet completely proficient in using accentuation for focus and that children generally pause more than adults, we asked whether pausing might be an available parameter for children to manipulate for focus. Sentences with varying focus structure were elicited from 10 Dutch-speaking 4 to 5 year olds and 9 Dutch-speaking adults by means of a picture-matching game. Comparing pause durations before focal and non-focal targets showed pre-target pauses to be significantly longer when the targets were focal than when they were not. Notably, the use of pausing was more robust in the children than in the adults, suggesting that children exploit pausing to mark focus more generally than adults do, at a stage where their mastery of the canonical cues to focus is still developing.

SWOT Analysis on Medical Informatics and Development Strategies

ERIC Educational Resources Information Center

Ma, Xiaoyan; Han, Zhongdong; Ma, Hua

2015-01-01

This article aims at clarifying the strategic significance of developing medical informatics, conducting SWOT analysis on this discipline and hence establishing the strategic objectives and focal points for its development.

Learning from an Owl.

ERIC Educational Resources Information Center

Greeves, Adrian

1988-01-01

Describes one creative writing teacher's use of an owl as a focal point for writing activities and how the writing activities aided the students' personal and creative development. Provides samples of student writing. (ARH)

Pharmacokinetic Study of Piracetam in Focal Cerebral Ischemic Rats.

PubMed

Paliwal, Pankaj; Dash, Debabrata; Krishnamurthy, Sairam

2018-04-01

Cerebral ischemia affects hepatic enzymes and brain permeability extensively. Piracetam was investigated up to phase III of clinical trials and there is lack of data on brain penetration in cerebral ischemic condition. Thus, knowledge of the pharmacokinetics and brain penetration of piracetam during ischemic condition would aid to improve pharmacotherapeutics in ischemic stroke. Focal cerebral ischemia was induced by middle cerebral artery occlusion for 2 h in male Wistar rats followed by reperfusion. After 24 h of middle cerebral artery occlusion or 22 h of reperfusion, piracetam was administered for pharmacokinetic, brain penetration, and pharmacological experiments. In pharmacokinetic study, blood samples were collected at different time points after 200-mg/kg (oral) and 75-mg/kg (intravenous) administration of piracetam through right external jugular vein cannulation. In brain penetration study, the cerebrospinal fluid, systemic blood, portal blood, and brain samples were collected at pre-designated time points after 200-mg/kg oral administration of piracetam. In a separate experiment, the pharmacological effect of the single oral dose of piracetam in middle cerebral artery occlusion was assessed at a dose of 200 mg/kg. All the pharmacokinetic parameters of piracetam including area under curve (AUC 0-24 ), maximum plasma concentration (C max ), time to reach the maximum plasma concentration (t max ), elimination half-life (t 1/2 ), volume of distribution (V z ), total body clearance, mean residence time, and bioavailability were found to be similar in ischemic stroke condition except for brain penetration. Piracetam exposure (AUC 0-2 ) in brain and CSF were found to be 2.4- and 3.1-fold higher, respectively, in ischemic stroke compared to control rats. Piracetam significantly reduced infarct volume by 35.77% caused by middle cerebral artery occlusion. There was no change in the pharmacokinetic parameters of piracetam in the ischemic stroke model except for brain penetration. This indicates that variables influencing brain penetration may not be limiting factors for use of piracetam in ischemic stroke.

Stress Field in Brazil with Focal Mechanism: Regional and Local Patterns

NASA Astrophysics Data System (ADS)

Dias, F.; Assumpcao, M.

2013-05-01

The knowledge of stress field is fundamental not only to understand driving forces and plate deformation but also in the study of intraplate seismicity. The stress field in Brazil has been determined mainly using focal mechanisms and a few breakout data and in-situ measurements. However the stress field still is poorly known in Brazil. The focal mechanisms of recent earthquakes (magnitude lower than 5 mb) were studied using waveform modeling. We stacked the record of several teleseismic stations ( delta > 30°) stacked groups of stations separated according to distance and azimuth. Every record was visually inspected and those with a good signal/noise ratio (SNR) were grouped in windows of ten degrees distance and stacked. The teleseismic P-wave of the stacked signals was modeled using the hudson96 program of Herrmann seismology package (Herrmann, 2002) and the consistency of focal mechanism with the first-motion was checked. Some events in central Brazil were recorded by closer stations (~ 1000 km) and the moment tensor was determined with the ISOLA code (Sokos & Zahradnik, 2008). With the focal mechanisms available in literature and those obtained in this work, we were able to identify some patterns: the central region shows a purely compressional pattern (E-W SHmax), which is predicted by regional theoretical models (Richardson & Coblentz, 1996 and the TD0 model of Lithgow & Bertelloni, 2004). Meanwhile in the Amazon we find an indication of SHmax oriented in the SE-NW direction, probably caused by the Caribbean plate interaction (Meijer, 1995). In northern coastal region, the compression rotates following the coastline, which indicates an important local component related to spreading effects at the continental/oceanic transition (Assumpção, 1998) and flexural stresses caused by sedimentary load in Amazon Fan. We determine the focal mechanism of several events in Brazil using different techniques according to the available data. The major difficulty is to determine focal mechanism of low magnitudes events (< 5.0 mb) using distant s seismograph stations. We find examples of stress perturbations induced by local effects (e.g. flexure and continental spreading). The results of this work should be useful for future numerical modeling of intraplate stress field. Assumpção,M.,1998.Seismicity and stresses in the Brazilian passive margin. Bull. Seism. Soc. Am., 88(1),160-169. Herrmann, R. B. (2002). Computer programs in seismology, St. Louis University Earthquake Center, St. Louis, Missouri, www.eas.slu .edu/eqc/eqccps.html. Lithgow-Bertelloni, C., & J.H. Guynn, 2004. Origin of the lithospheric stress field. J. Geophys. Res., 109, B01408, doi:10.1029/2003JB002467. Meijer, P.T., 1995. Dynamics of active continental margins: the Andes and the Aegean regions. PhD Thesis, Utrecht University, The Netherlands. Sokos, E., Zahradnik, J., (2008). ISOLA a Fortran code and a Matlab GUI to perform multiple-point source inversion of seismic data, Computers and Geosciences, 34, 967-97. Watts, A. B., M. Rodger, C. Peirce, C. J. Greenroyd, and R. W. Hobbs (2009). Seismic structure, gravity anomalies, and flexure of the Amazon continental margin, NE Brazil, J. Geophys. Res., 114, B07103, doi:10.1029/2008JB006259.

Dewey's Logic as a Methodological Grounding Point for Practitioner-Based Inquiry

ERIC Educational Resources Information Center

Demetrion, George

2012-01-01

The purpose of this essay is to draw out key insights from Dewey's important text "Logic: The Theory of Inquiry" to provide theoretical and practical support for the emergent field of teacher research. The specific focal point is the argument in Cochran-Smith and Lytle's "Inside/Outside: Teacher Research and Knowledge" on the significance of…

Epidemiological, clinical and genetic aspects of adult onset isolated focal dystonia in Ireland.

PubMed

Williams, L; McGovern, E; Kimmich, O; Molloy, A; Beiser, I; Butler, J S; Molloy, F; Logan, P; Healy, D G; Lynch, T; Walsh, R; Cassidy, L; Moriarty, P; Moore, H; McSwiney, T; Walsh, C; O'Riordan, S; Hutchinson, M

2017-01-01

Adult onset idiopathic isolated focal dystonia presents with a number of phenotypes. Reported prevalence rates vary considerably; well-characterized cohorts are important to our understanding of this disorder. To perform a nationwide epidemiological study of adult onset idiopathic isolated focal dystonia in the Republic of Ireland. Patients with adult onset idiopathic isolated focal dystonia were recruited from multiple sources. Diagnosis was based on assessment by a neurologist with an expertise in movement disorders. When consent was obtained, a number of clinical features including family history were assessed. On the prevalence date there were 592 individuals in Ireland with adult onset idiopathic isolated focal dystonia, a point prevalence of 17.8 per 100 000 (95% confidence interval 16.4-19.2). Phenotype numbers were cervical dystonia 410 (69.2%), blepharospasm 102 (17.2%), focal hand dystonia 39 (6.6%), spasmodic dysphonia 18 (3.0%), musician's dystonia 17 (2.9%) and oromandibular dystonia six (1.0%). Sixty-two (16.5%) of 375 consenting index cases had a relative with clinically confirmed adult onset idiopathic isolated focal dystonia (18 multiplex and 24 duplex families). Marked variations in the proportions of patients with tremor, segmental spread, sensory tricks, pain and psychiatric symptoms by phenotype were documented. The prevalence of adult onset idiopathic isolated focal dystonia in Ireland is higher than that recorded in many similar service-based epidemiological studies but is still likely to be an underestimate. The low proportion of individuals with blepharospasm may reflect reduced environmental exposure to sunlight in Ireland. This study will serve as a resource for international comparative studies of environmental and genetic factors in the pathogenesis of the disorder. © 2016 EAN.

Short-Lasting Episodes of Torsade de Pointes in the Chronic Atrioventricular Block Dog Model Have a Focal Mechanism, While Longer-Lasting Episodes Are Maintained by Re-Entry.

PubMed

Vandersickel, Nele; Bossu, Alexandre; De Neve, Jan; Dunnink, Albert; Meijborg, Veronique M F; van der Heyden, Marcel A G; Beekman, Jet D M; De Bakker, Jacques M T; Vos, Marc A; Panfilov, Alexander V

2017-12-26

This study investigated the arrhythmogenic mechanisms responsible for torsade de pointes (TdP) in the chronic atrioventricular block dog model, known for its high susceptibility for TdP. The mechanism of TdP arrhythmias has been under debate for many years. Focal activity as well as re-entry have both been mentioned in the initiation and the perpetuation of TdP. In 5 TdP-sensitive chronic atrioventricular block dogs, 56 needle electrodes were evenly distributed transmurally to record 240 unipolar local electrograms simultaneously. Nonterminating (NT) episodes were defibrillated after 10 s. Software was developed to automatically detect activation times and to create 3-dimensional visualizations of the arrhythmia. For each episode of ectopic activity (ranging from 2 beats to NT episodes), a novel methodology was created to construct directed graphs of the wave propagation and detect re-entry loops by using an iterative depth-first-search algorithm. Depending on the TdP definition (number of consecutive ectopic beats), we analyzed 29 to 54 TdP: 29 were longer than 5 beats. In the total group, 9 were NT and 45 were self-terminating. Initiation and termination were always based on focal activity. Re-entry becomes more important in the longer-lasting episodes (>14 beats), whereas in all NT TdP, re-entry was the last active mechanism. During re-entry, excitation fronts were constantly present in the heart, while during focal TdP, there was always a silent interval between 2 consecutive waves (142 ms) during which excitation fronts were absent. Interbeat intervals were significantly smaller for re-entry episodes-220 versus 310 ms in focal. Electrograms recorded in particular areas during NT TdP episodes had significantly smaller amplitude (0.38) than during focal episodes (0.59). TdP can be driven by focal activity as well as by re-entry depending on the duration of the episode. NT episodes are always maintained by re-entry, which can be identified in local unipolar electrograms by shorter interbeat intervals and smaller deflection amplitude. Copyright © 2017 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

High-numerical-aperture-based virtual point detectors for photoacoustic tomography

NASA Astrophysics Data System (ADS)

Li, Changhui; Wang, Lihong V.

2008-07-01

The focal point of a high-numerical-aperture (NA) ultrasonic transducer can be used as a virtual point detector. This virtual point detector detects omnidirectionally over a wide acceptance angle. It also combines a large active transducer surface and a small effective virtual detector size. Thus the sensitivity is high compared with that of a real point detector, and the aperture effect is small compared with that of a finite size transducer. We present two kinds of high-NA-based virtual point detectors and their successful application in photoacoustic tomography. They can also be applied in other ultrasound-related fields.

The College Mathematics Experience and Changes in Majors: A Structural Model Analysis.

ERIC Educational Resources Information Center

Whiteley, Meredith A.; Fenske, Robert H.

1990-01-01

Testing of a structural equation model with college mathematics experience as the focal variable in 745 students' final decisions concerning major or dropping out over 4 years of college yielded separate model estimates for 3 fields: scientific/technical, quantitative business, and business management majors. (Author/MSE)

Sierra Leone Estuary

NASA Image and Video Library

2014-02-05

This image acquired by NASA Terra spacecraft is of the Sierra Leone estuary, which became a focal point for trade and interaction between Africans and Europeans because of its exceptional harbor, starting in the mid-15th century.

77 FR 66476 - National Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-05

... by teleconference. Members of the public who wish to obtain the listen-only call-in number, access... policies and strategies. FEMA's Office of the NAC serves as the focal point for all NAC coordination...

Training to Survive the Hazard Called Education.

ERIC Educational Resources Information Center

Agassi, Joseph

1984-01-01

The evils of compulsory instruction and the problems of educational reform in the general education system are explored. Strategies which target student boredom as a focal point are offered for improving education. (DF)

Relay telescope for high power laser alignment system

DOEpatents

Dane, C. Brent; Hackel, Lloyd; Harris, Fritz B.

2006-09-19

A laser system includes an optical path having an intracavity relay telescope with a telescope focal point for imaging an output of the gain medium between an image location at or near the gain medium and an image location at or near an output coupler for the laser system. A kinematic mount is provided within a vacuum chamber, and adapted to secure beam baffles near the telescope focal point. An access port on the vacuum chamber is adapted for allowing insertion and removal of the beam baffles. A first baffle formed using an alignment pinhole aperture is used during alignment of the laser system. A second tapered baffle replaces the alignment aperture during operation and acts as a far-field baffle in which off angle beams strike the baffle a grazing angle of incidence, reducing fluence levels at the impact areas.

Numerical study and ex vivo assessment of HIFU treatment time reduction through optimization of focal point trajectory

NASA Astrophysics Data System (ADS)

Grisey, A.; Yon, S.; Pechoux, T.; Letort, V.; Lafitte, P.

2017-03-01

Treatment time reduction is a key issue to expand the use of high intensity focused ultrasound (HIFU) surgery, especially for benign pathologies. This study aims at quantitatively assessing the potential reduction of the treatment time arising from moving the focal point during long pulses. In this context, the optimization of the focal point trajectory is crucial to achieve a uniform thermal dose repartition and avoid boiling. At first, a numerical optimization algorithm was used to generate efficient trajectories. Thermal conduction was simulated in 3D with a finite difference code and damages to the tissue were modeled using the thermal dose formula. Given an initial trajectory, the thermal dose field was first computed, then, making use of Pontryagin's maximum principle, the trajectory was iteratively refined. Several initial trajectories were tested. Then, an ex vivo study was conducted in order to validate the efficicency of the resulting optimized strategies. Single pulses were performed at 3MHz on fresh veal liver samples with an Echopulse and the size of each unitary lesion was assessed by cutting each sample along three orthogonal planes and measuring the dimension of the whitened area based on photographs. We propose a promising approach to significantly shorten HIFU treatment time: the numerical optimization algorithm was shown to provide a reliable insight on trajectories that can improve treatment strategies. The model must now be improved in order to take in vivo conditions into account and extensively validated.

Poliomyelitis eradication – the review of notifications from the years 2010-2016 sent to National IHR Focal Point

PubMed

Radziszewski, Franciszek; Janiec, Janusz; Henszel, Łukasz; Izdebski, Radosław; Polański, Piotr

Polio eradication programme was launched after World Health Assembly in 1988. Despite considerable decrease in reported cases it still constitutes a significant public health threat. All WHO member state is bound to appoint National IHR Focal Point, which operates based on International Health Regulations (2005), which were enacted during the World Health Assembly in 2005. In Poland National IHR Focal Point (IHR NFP in Poland) operates since 2007, and is located in the Department of Epidemiology, in National Institute of Public Health - National Institute of Hygiene. Its aim is to acquire, assess and to transfer information on events which may constitute an international threat for the public health. IHR NFP in Poland has an access to WHO’s Event Information Site (EIS) as well as Early Warning and Response System (EWRS) with reading-only credentials. Both platforms are of limited access (1). Among recipients of IHR NFP notifications and information are experts from many fields such as epidemiology, virology, bacteriology and others- related to specific type of notification, as well as specific and appointed members of state’s administration and authorities in the field of public health. In this paper a review of notifications on the subject of poliomyelitis, sent to IHR NFP in Poland in the years 2010-2016 is presented, as well as references to poliomyelitis epidemiological situation were made based on the date from Global Polio Eradication Initiative.

Effect on High-Intensity Fields of a Tough Hydrophone With Hydrothermal PZT Thick-Film Vibrator and Titanium Front Layer.

PubMed

Okada, Nagaya; Takeuchi, Shinichi

2017-07-01

A novel tough hydrophone was fabricated by depositing hydrothermally synthesized lead zirconate titanate polycrystalline film on the back-side surface of a titanium plate. Our developed tough hydrophone resisted damage in a high-pressure field (15 MPa) at a focal point of a sinusoidal continuous wave driven by a concave high-intensity focused ultrasound (HIFU) transducer with up to 50 W of power input to the sound source. The hydrophone was suitable for the HIFU field, even though the hydrophone has a flat-shape tip of 3.5 mm diameter, which is slightly larger than the wavelength of a few megahertz. In this paper, experiments are performed to assess the effect on the HIFU field of changing the shape of the tough hydrophone, with the aim of developing a tough hydrophone. The spatial distribution of the acoustic bubbles around the focal point was visualized by using ultrasonic diagnostic equipment with the tough hydrophone located at the focal point of the HIFU transducer. From the visualization, the trapped acoustic bubbles were seen to arise from the standing wave, which implies that the acoustic pressure is reduced by this cloud of acoustic bubbles that appeared during hydrophone measurement. Although cavitation and acoustic bubbles may be unavoidable when using high-intensity ultrasound, the estimated result of evaluating acoustic fields without misunderstanding by acoustic bubbles can be obtained by the aid of visualizing bubbles around the tough hydrophone.

Cassegrain Solar Concentrator System for ISRU Material Processing

NASA Technical Reports Server (NTRS)

Colozza, Anthony J.; Macosko, Robert; Castle, Charles; Sacksteder, Kurt; Suzuki, Nantel H.; Mulherin, James

2012-01-01

A 0.5 m diameter Cassegrain concentrator was constructed as a means of providing highly concentrated sunlight for the demonstration processing of lunar simulated regolith and other NASA In-Situ Resource Utilization Project (ISRU) reaction processes. The concentrator is constructed of aluminum with a concentration ratio of approximately 3000 to 1. The concentrator focuses solar energy into a movable tray located behind the concentrator. This tray can hold simulated regolith or any other material and or device to be tested with concentrated solar energy. The tray is movable in one axis. A 2-axis extended optical system was also designed and fabricated. The extended optical system is added to the back of the primary concentrator in place of the moveable test tray and associated apparatus. With this optical system the focused sunlight can be extended from the back of the primary concentrator toward the ground with the added advantage of moving the focal point axially and laterally relative to the ground. This allows holding the focal point at a fixed position on the ground as the primary concentrator tracks the sun. Also, by design, the focal point size was reduced via the extended optics by a factor of 2 and results in a concentration ratio for the system of approximately 6,000 to 1.The designs of both optical systems are discussed. The results from simulated regolith melting tests are presented as well as the operational experience of utilizing the Cassegrain concentrator system.

Tracking initially unresolved thrusting objects in 3D using a single stationary optical sensor

NASA Astrophysics Data System (ADS)

Lu, Qin; Bar-Shalom, Yaakov; Willett, Peter; Granström, Karl; Ben-Dov, R.; Milgrom, B.

2017-05-01

This paper considers the problem of estimating the 3D states of a salvo of thrusting/ballistic endo-atmospheric objects using 2D Cartesian measurements from the focal plane array (FPA) of a single fixed optical sensor. Since the initial separations in the FPA are smaller than the resolution of the sensor, this results in merged measurements in the FPA, compounding the usual false-alarm and missed-detection uncertainty. We present a two-step methodology. First, we assume a Wiener process acceleration (WPA) model for the motion of the images of the projectiles in the optical sensor's FPA. We model the merged measurements with increased variance, and thence employ a multi-Bernoulli (MB) filter using the 2D measurements in the FPA. Second, using the set of associated measurements for each confirmed MB track, we formulate a parameter estimation problem, whose maximum likelihood estimate can be obtained via numerical search and can be used for impact point prediction. Simulation results illustrate the performance of the proposed method.

ASEAN GMP and pharmaceutical industries in Indonesia.

PubMed

Soesilo, S; Sitorus, U

1995-01-01

Indonesia was appointed by the ASEAN Technical Cooperation in Pharmaceutical as a focal point and to coordinate the development of practical guidelines for the implementation of GMP. The ASEAN GMP Guidelines were endorsed by the ASEAN Technical Cooperation in Pharmaceutical in 1988, which among others required separation of Beta-Lactam dedicated facilities and three degrees of cleanliness for production areas. As it was realised that drug manufacturers in developing countries need more detailed guidelines to be able to implement the GMP, an Operational Manual for GMP was also prepared for providing examples of SOPs lay-outs, documentation etc. It was agreed by the technical cooperation group to leave the implementation of GMP to each member country. However, the ASEAN Manual for Inspection of GMP was drafted and endorsed by the group and training of ASEAN Drug Inspectors was organized to support the implementation. The ASEAN GMP is being implemented in Indonesia through a five-year, stepwise implementation plan, starting in 1989.

Large aperture diffractive space telescope

DOEpatents

Hyde, Roderick A.

2001-01-01

A large (10's of meters) aperture space telescope including two separate spacecraft--an optical primary objective lens functioning as a magnifying glass and an optical secondary functioning as an eyepiece. The spacecraft are spaced up to several kilometers apart with the eyepiece directly behind the magnifying glass "aiming" at an intended target with their relative orientation determining the optical axis of the telescope and hence the targets being observed. The objective lens includes a very large-aperture, very-thin-membrane, diffractive lens, e.g., a Fresnel lens, which intercepts incoming light over its full aperture and focuses it towards the eyepiece. The eyepiece has a much smaller, meter-scale aperture and is designed to move along the focal surface of the objective lens, gathering up the incoming light and converting it to high quality images. The positions of the two space craft are controlled both to maintain a good optical focus and to point at desired targets which may be either earth bound or celestial.

[Erectile function and ablative surgery of penile tumors].

PubMed

Pisani, E; Austoni, E; Trinchieri, A; Ceresoli, A; Mantovani, F; Colombo, F; Mastromarino, G; Vecchio, D; Canclini, L; Fenice, O

1994-02-01

The Authors try to show the possibility to combine radical excision with minimal invasiveness in the surgery of penile cancer. The focal point of every therapeutic decision is correct clinical staging. Unfortunately there's some confusion in the two international staging systems (TNM and Jackson's classification). In fact it's not clear the anatomical difference between epithelioma of the glans infiltrating corpus spongiosum and subcoronary epithelioma of the shaft infiltrating the corpora cavernosa. It's obvious that the infiltration of the corpora cavernosa is a far more aggressive oncological manifestation than that of tumour infiltrating the corpus spongiosum. So we consider Jackson's classification more congenial. In terms of surgery this anatomical independence makes it easy to consider the corpora cavernosa as a distinct entity, so they remain perfectly functional when separated from the glandulo-spongio-urethral unit with its vasculo-nervous bundle. This makes conservation of the erectile function, when clinical staging show us that the tumour is not infiltrating the corpora cavernosa. The Authors show their results, which seem to be rather good.

High dose rate brachytherapy source measurement intercomparison.

PubMed

Poder, Joel; Smith, Ryan L; Shelton, Nikki; Whitaker, May; Butler, Duncan; Haworth, Annette

2017-06-01

This work presents a comparison of air kerma rate (AKR) measurements performed by multiple radiotherapy centres for a single HDR 192 Ir source. Two separate groups (consisting of 15 centres) performed AKR measurements at one of two host centres in Australia. Each group travelled to one of the host centres and measured the AKR of a single 192 Ir source using their own equipment and local protocols. Results were compared to the 192 Ir source calibration certificate provided by the manufacturer by means of a ratio of measured to certified AKR. The comparisons showed remarkably consistent results with the maximum deviation in measurement from the decay-corrected source certificate value being 1.1%. The maximum percentage difference between any two measurements was less than 2%. The comparisons demonstrated the consistency of well-chambers used for 192 Ir AKR measurements in Australia, despite the lack of a local calibration service, and served as a valuable focal point for the exchange of ideas and dosimetry methods.

a Plutonium Ceramic Target for Masha

NASA Astrophysics Data System (ADS)

Wilk, P. A.; Shaughnessy, D. A.; Moody, K. J.; Kenneally, J. M.; Wild, J. F.; Stoyer, M. A.; Patin, J. B.; Lougheed, R. W.; Ebbinghaus, B. B.; Landingham, R. L.; Oganessian, Yu. Ts.; Yeremin, A. V.; Dmitriev, S. N.

2005-09-01

We are currently developing a plutonium ceramic target for the MASHA mass separator. The MASHA separator will use a thick plutonium ceramic target capable of tolerating temperatures up to 2000 °C. Promising candidates for the target include oxides and carbides, although more research into their thermodynamic properties will be required. Reaction products will diffuse out of the target into an ion source, where they will then be transported through the separator to a position-sensitive focal-plane detector array. Experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments where the chemical properties of the heaviest elements are studied.

Using a focal-plane array to estimate antenna pointing errors

NASA Technical Reports Server (NTRS)

Zohar, S.; Vilnrotter, V. A.

1991-01-01

The use of extra collecting horns in the focal plane of an antenna as a means of determining the Direction of Arrival (DOA) of the signal impinging on it, provided it is within the antenna beam, is considered. Our analysis yields a relatively simple algorithm to extract the DOA from the horns' outputs. An algorithm which, in effect, measures the thermal noise of the horns' signals and determines its effect on the uncertainty of the extracted DOA parameters is developed. Both algorithms were implemented in software and tested in simulated data. Based on these tests, it is concluded that this is a viable approach to the DOA determination. Though the results obtained are of general applicability, the particular motivation for the present work is their application to the pointing of a mechanically deformed antenna. It is anticipated that the pointing algorithm developed for a deformed antenna could be obtained as a small perturbation of the algorithm developed for an undeformed antenna. In this context, it should be pointed out that, with a deformed antenna, the array of horns and its associated circuitry constitute the main part of the deformation-compensation system. In this case, the pointing system proposed may be viewed as an additional task carried out by the deformation-compensation hardware.

Converging PET and fMRI evidence for a common area involved in human focal epilepsies

PubMed Central

Laufs, H.; Richardson, M.P.; Salek-Haddadi, A.; Vollmar, C.; Duncan, J.S.; Gale, K.; Lemieux, L.; Löscher, W.

2011-01-01

Objectives: Experiments in animal models have identified specific subcortical anatomic circuits, which are critically involved in the pathogenesis and control of seizure activity. However, whether such anatomic substrates also exist in human epilepsy is not known. Methods: We studied 2 separate groups of patients with focal epilepsies arising from any cortical location using either simultaneous EEG-fMRI (n = 19 patients) or [11C]flumazenil PET (n = 18). Results: Time-locked with the interictal epileptiform discharges, we found significant hemodynamic increases common to all patients near the frontal piriform cortex ipsilateral to the presumed cortical focus. GABAA receptor binding in the same area was reduced in patients with more frequent seizures. Conclusions: Our findings of cerebral blood flow and GABAergic changes, irrespective of where interictal or ictal activity occurs in the cortex, suggest that this area of the human primary olfactory cortex may be an attractive new target for epilepsy therapy, including neurosurgery, electrical stimulation, and focal drug delivery. PMID:21849655

Malignant mixed müllerian tumors. An ultrastructural and immunohistochemical analysis with histogenetic considerations.

PubMed

Geisinger, K R; Dabbs, D J; Marshall, R B

1987-05-15

In the female genital tract, malignant mixed müllerian tumors (MMTs) are uncommon neoplasms of uncertain histogenesis. We have examined 11 MMTs by both electron microscopy (EM) and immunoperoxidase techniques (IPX). Eight were of endometrial, two were of ovarian, and one of tubal origins. The IPX analysis included monoclonal antibodies to keratin (k) and vimentin (v) and a polyclonal antibody to myoglobin. Carcinomatous elements were always keratin positive (K+) and were focally positive for vimentin in six tumors. Homologous stromal sarcoma cells were vimentin positive (V+) and in three tumors were focally K+. Ultrastructurally, the epithelial cells were not highly differentiated and the sarcomatous elements generally resembled normal proliferative-phase stromal cells. The epithelial and stromal elements were separated by a thin basal lamina that only rarely and focally had discontinuities. No transitional cellular forms were identified. A definite positive myoglobin reaction was seen in two of the four neoplasms in which rhabdomyoblasts were identified by light microscopy. Myofilaments were identified by electron microscope in three neoplasms.

A Methodology to Assess the Impact of Optical and Electronic Crosstalk in a New Generation of Sensors Using Heritage Sensors

NASA Technical Reports Server (NTRS)

Oudrari, Hassan; Schwarting, Thomas; Chiang, Kwo-Fu; McIntire, Jeff; Pan, Chunhui; Xiong, Xiaoxiong; Butler, James

2010-01-01

Electronic and optical crosstalk are radiometric challenges that often exist in the focal plane design in many sensors Such as MODIS. A methodology is described to assess the impact due to optical and electronic crosstalk on the measured radiance, and thereafter, the retrieval of geophysical products using MODIS Level I data sets. Based on a postulated set of electronic and optical crosstalk coefficients, and a set of MODIS scenes, we have simulated a system signal contamination on any detector on a focal plane when another detector on that focal plane is stimulated with a geophysical signal. The original MODIS scenes and the crosstalk impacted scenes can be used with validated geophysical algorithms to derive the final data products. Products contaminated with crosstalk are then compared to those without contamination to assess the impact magnitude and location, and will allow us to separate Out-Of-Band (OOB) leaks from hand-to-hand optical crosstalk, and identify potential failures to meet climate research requirements.

Nuclear Safety Information Center, Its Products and Services

ERIC Educational Resources Information Center

Buchanan, J. R.

1970-01-01

The Nuclear Safety Information Center (NSIC) serves as a focal point for the collection, analysis and dissemination of information related to safety problems encountered in the design, analysis, and operation of nuclear facilities. (Author/AB)

78 FR 38067 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

... (Amendment). Abstract: The National Fire Academy was established to advance the professional development of... Management Agency Institute serves as the national focal point for the development and delivery of emergency...

Robotic autopositioning of the operating microscope.

PubMed

Oppenlander, Mark E; Chowdhry, Shakeel A; Merkl, Brandon; Hattendorf, Guido M; Nakaji, Peter; Spetzler, Robert F

2014-06-01

Use of the operating microscope has become pervasive since its introduction to the neurosurgical world. Neuronavigation fused with the operating microscope has allowed accurate correlation of the focal point of the microscope and its location on the downloaded imaging study. However, the robotic ability of the Pentero microscope has not been utilized to orient the angle of the microscope or to change its focal length to hone in on a predefined target. To report a novel technology that allows automatic positioning of the operating microscope onto a set target and utilization of a planned trajectory, either determined with the StealthStation S7 by using preoperative imaging or intraoperatively with the microscope. By utilizing the current motorized capabilities of the Zeiss OPMI Pentero microscope, a robotic autopositioning feature was developed in collaboration with Surgical Technologies, Medtronic, Inc. (StealthStation S7). The system is currently being tested at the Barrow Neurological Institute. Three options were developed for automatically positioning the microscope: AutoLock Current Point, Align Parallel to Plan, and Point to Plan Target. These options allow the microscope to pivot around the lesion, hover in a set plane parallel to the determined trajectory, or rotate and point to a set target point, respectively. Integration of automatic microscope positioning into the operative workflow has potential to increase operative efficacy and safety. This technology is best suited for precise trajectories and entry points into deep-seated lesions.

Digital focusing of OCT images based on scalar diffraction theory and information entropy.

PubMed

Liu, Guozhong; Zhi, Zhongwei; Wang, Ruikang K

2012-11-01

This paper describes a digital method that is capable of automatically focusing optical coherence tomography (OCT) en face images without prior knowledge of the point spread function of the imaging system. The method utilizes a scalar diffraction model to simulate wave propagation from out-of-focus scatter to the focal plane, from which the propagation distance between the out-of-focus plane and the focal plane is determined automatically via an image-definition-evaluation criterion based on information entropy theory. By use of the proposed approach, we demonstrate that the lateral resolution close to that at the focal plane can be recovered from the imaging planes outside the depth of field region with minimal loss of resolution. Fresh onion tissues and mouse fat tissues are used in the experiments to show the performance of the proposed method.

A general purpose wideband optical spatial frequency spectrum analyzer

NASA Technical Reports Server (NTRS)

Ballard, G. S.; Mellor, F. A.

1972-01-01

The light scattered at various angles by a transparent media is studied. An example of these applications is the optical Fourier spectrum measurement resulting from various spatial frequencies which were recorded on a photographic emulsion. A method for obtaining these measurements consists of illuminating the test object with parallel monochromatic light. A stationary lens, placed in the resulting wavefield at a distance of one focal length from the object, will focus parallel waves emanating from the test object at a point lying in the focal plane of the lens. A light detector with a small filtering aperture is then used to measure the intensity variation of the light in the focal or transform plane of the lens. Such measurements require the use of a lens which is highly corrected for all of the common aberrations except chromatic aberration.

Kalman Filter for Calibrating a Telescope Focal Plane

NASA Technical Reports Server (NTRS)

Kang, Bryan; Bayard, David

2006-01-01

The instrument-pointing frame (IPF) Kalman filter, and an algorithm that implements this filter, have been devised for calibrating the focal plane of a telescope. As used here, calibration signifies, more specifically, a combination of measurements and calculations directed toward ensuring accuracy in aiming the telescope and determining the locations of objects imaged in various arrays of photodetectors in instruments located on the focal plane. The IPF Kalman filter was originally intended for application to a spaceborne infrared astronomical telescope, but can also be applied to other spaceborne and ground-based telescopes. In the traditional approach to calibration of a telescope, (1) one team of experts concentrates on estimating parameters (e.g., pointing alignments and gyroscope drifts) that are classified as being of primarily an engineering nature, (2) another team of experts concentrates on estimating calibration parameters (e.g., plate scales and optical distortions) that are classified as being primarily of a scientific nature, and (3) the two teams repeatedly exchange data in an iterative process in which each team refines its estimates with the help of the data provided by the other team. This iterative process is inefficient and uneconomical because it is time-consuming and entails the maintenance of two survey teams and the development of computer programs specific to the requirements of each team. Moreover, theoretical analysis reveals that the engineering/ science iterative approach is not optimal in that it does not yield the best estimates of focal-plane parameters and, depending on the application, may not even enable convergence toward a set of estimates.

A Micromechanical INS/GPS System for Small Satellites

NASA Technical Reports Server (NTRS)

Barbour, N.; Brand, T.; Haley, R.; Socha, M.; Stoll, J.; Ward, P.; Weinberg, M.

1995-01-01

The cost and complexity of large satellite space missions continue to escalate. To reduce costs, more attention is being directed toward small lightweight satellites where future demand is expected to grow dramatically. Specifically, micromechanical inertial systems and microstrip global positioning system (GPS) antennas incorporating flip-chip bonding, application specific integrated circuits (ASIC) and MCM technologies will be required. Traditional microsatellite pointing systems do not employ active control. Many systems allow the satellite to point coarsely using gravity gradient, then attempt to maintain the image on the focal plane with fast-steering mirrors. Draper's approach is to actively control the line of sight pointing by utilizing on-board attitude determination with micromechanical inertial sensors and reaction wheel control actuators. Draper has developed commercial and tactical-grade micromechanical inertial sensors, The small size, low weight, and low cost of these gyroscopes and accelerometers enable systems previously impractical because of size and cost. Evolving micromechanical inertial sensors can be applied to closed-loop, active control of small satellites for micro-radian precision-pointing missions. An inertial reference feedback control loop can be used to determine attitude and line of sight jitter to provide error information to the controller for correction. At low frequencies, the error signal is provided by GPS. At higher frequencies, feedback is provided by the micromechanical gyros. This blending of sensors provides wide-band sensing from dc to operational frequencies. First order simulation has shown that the performance of existing micromechanical gyros, with integrated GPS, is feasible for a pointing mission of 10 micro-radians of jitter stability and approximately 1 milli-radian absolute error, for a satellite with 1 meter antenna separation. Improved performance micromechanical sensors currently under development will be suitable for a range of micro-nano-satellite applications.

Investigation on dynamics of red blood cells through their behavior as biophotonic lenses.

PubMed

Memmolo, Pasquale; Merola, Francesco; Miccio, Lisa; Mugnano, Martina; Ferraro, Pietro

2016-12-01

The possibility to adopt biological matter as photonic optical elements can open scenarios in biophotonics research. Recently, it has been demonstrated that a red blood cell (RBC) can be seen as an optofluidic microlens by showing its imaging capability as well as its focal tunability. Moreover, correlation between an RBC’s morphology and its behavior as a refractive optical element has been established and its exploitation for biomedical diagnostic purposes has been foreseen. In fact, any deviation from the healthy RBC morphology can be seen as additional aberration in the optical wavefront passing through the cell. By this concept, accurate localization of focal spots of RBCs can become very useful in the blood disorders identification. We investigate the three-dimensional positioning of such focal spots over time for samples with two different osmolarity conditions, i.e., when they assume discocyte and spherical shapes, respectively. We also demonstrate that a temporal variation of an RBC’s focal points along the optical axis is correlated to the temporal fluctuations in the RBC’s thickness maps. Furthermore, we show a sort of synchronization of the whole erythrocytes ensemble.

Local activation time sampling density for atrial tachycardia contact mapping: how much is enough?

PubMed

Williams, Steven E; Harrison, James L; Chubb, Henry; Whitaker, John; Kiedrowicz, Radek; Rinaldi, Christopher A; Cooklin, Michael; Wright, Matthew; Niederer, Steven; O'Neill, Mark D

2018-02-01

Local activation time (LAT) mapping forms the cornerstone of atrial tachycardia diagnosis. Although anatomic and positional accuracy of electroanatomic mapping (EAM) systems have been validated, the effect of electrode sampling density on LAT map reconstruction is not known. Here, we study the effect of chamber geometry and activation complexity on optimal LAT sampling density using a combined in silico and in vivo approach. In vivo 21 atrial tachycardia maps were studied in three groups: (1) focal activation, (2) macro-re-entry, and (3) localized re-entry. In silico activation was simulated on a 4×4cm atrial monolayer, sampled randomly at 0.25-10 points/cm2 and used to re-interpolate LAT maps. Activation patterns were studied in the geometrically simple porcine right atrium (RA) and complex human left atrium (LA). Activation complexity was introduced into the porcine RA by incomplete inter-caval linear ablation. In all cases, optimal sampling density was defined as the highest density resulting in minimal further error reduction in the re-interpolated maps. Optimal sampling densities for LA tachycardias were 0.67 ± 0.17 points/cm2 (focal activation), 1.05 ± 0.32 points/cm2 (macro-re-entry) and 1.23 ± 0.26 points/cm2 (localized re-entry), P = 0.0031. Increasing activation complexity was associated with increased optimal sampling density both in silico (focal activation 1.09 ± 0.14 points/cm2; re-entry 1.44 ± 0.49 points/cm2; spiral-wave 1.50 ± 0.34 points/cm2, P < 0.0001) and in vivo (porcine RA pre-ablation 0.45 ± 0.13 vs. post-ablation 0.78 ± 0.17 points/cm2, P = 0.0008). Increasing chamber geometry was also associated with increased optimal sampling density (0.61 ± 0.22 points/cm2 vs. 1.0 ± 0.34 points/cm2, P = 0.0015). Optimal sampling densities can be identified to maximize diagnostic yield of LAT maps. Greater sampling density is required to correctly reveal complex activation and represent activation across complex geometries. Overall, the optimal sampling density for LAT map interpolation defined in this study was ∼1.0-1.5 points/cm2. Published on behalf of the European Society of Cardiology

Focal plane wavefront sensor achromatization: The multireference self-coherent camera

NASA Astrophysics Data System (ADS)

Delorme, J. R.; Galicher, R.; Baudoz, P.; Rousset, G.; Mazoyer, J.; Dupuis, O.

2016-04-01

Context. High contrast imaging and spectroscopy provide unique constraints for exoplanet formation models as well as for planetary atmosphere models. But this can be challenging because of the planet-to-star small angular separation (<1 arcsec) and high flux ratio (>105). Recently, optimized instruments like VLT/SPHERE and Gemini/GPI were installed on 8m-class telescopes. These will probe young gazeous exoplanets at large separations (≳1 au) but, because of uncalibrated phase and amplitude aberrations that induce speckles in the coronagraphic images, they are not able to detect older and fainter planets. Aims: There are always aberrations that are slowly evolving in time. They create quasi-static speckles that cannot be calibrated a posteriori with sufficient accuracy. An active correction of these speckles is thus needed to reach very high contrast levels (>106-107). This requires a focal plane wavefront sensor. Our team proposed a self coherent camera, the performance of which was demonstrated in the laboratory. As for all focal plane wavefront sensors, these are sensitive to chromatism and we propose an upgrade that mitigates the chromatism effects. Methods: First, we recall the principle of the self-coherent camera and we explain its limitations in polychromatic light. Then, we present and numerically study two upgrades to mitigate chromatism effects: the optical path difference method and the multireference self-coherent camera. Finally, we present laboratory tests of the latter solution. Results: We demonstrate in the laboratory that the multireference self-coherent camera can be used as a focal plane wavefront sensor in polychromatic light using an 80 nm bandwidth at 640 nm (bandwidth of 12.5%). We reach a performance that is close to the chromatic limitations of our bench: 1σ contrast of 4.5 × 10-8 between 5 and 17 λ0/D. Conclusions: The performance of the MRSCC is promising for future high-contrast imaging instruments that aim to actively minimize the speckle intensity so as to detect and spectrally characterize faint old or light gaseous planets.

Reflective Properties of a Parabolic Mirror.

ERIC Educational Resources Information Center

Ramsey, Gordon P.

1991-01-01

An incident light ray parallel to the optical axis of a parabolic mirror will be reflected at the focal point and vice versa. Presents a mathematical proof that uses calculus, algebra, and geometry to prove this reflective property. (MDH)

Food for Thought.

ERIC Educational Resources Information Center

Knight, Ruth

1984-01-01

Discusses various ways in which snacks are used as the focal point of science lessons. They include writing a laboratory report after experimenting (and eating) lollipops and preparing peanut butter and jelly sandwiches following the exact directions supplied by students. (JN)

Integration of transportation for improved mobility.

DOT National Transportation Integrated Search

2017-07-04

Mobility management and improvement have become the focal point of the federal, state, and local transportation agencies over the last decade. Even with decreasing vehicle-miles-traveled (VMT) over the same time span, the congestion and delays have n...

Projection of distributed-collector solar-thermal electric power plant economics to years 1990-2000

NASA Technical Reports Server (NTRS)

Fujita, T.; Elgabalawi, N.; Herrera, G.; Turner, R. H.

1977-01-01

A preliminary comparative evaluation of distributed-collector solar thermal power plants was undertaken by projecting power plant economics of selected systems to the 1990 to 2000 time frame. The selected systems include: (1) fixed orientation collectors with concentrating reflectors and vacuum tube absorbers, (2) one axis tracking linear concentrator including parabolic trough and variable slat designs, and (3) two axis tracking parabolic dish systems including concepts with small heat engine-electric generator assemblies at each focal point as well as approaches having steam generators at the focal point with pipeline collection to a central power conversion unit. Comparisons are presented primarily in terms of energy cost and capital cost over a wide range of operating load factors. Sensitvity of energy costs for a range of efficiency and cost of major subsystems/components is presented to delineate critical technological development needs.

Development and Testing of a Power Trough System Using a Structurally-Efficient, High-Performance, Large-Aperture Concentrator with Thin Glass Reflector and Focal Point Rotation

DOE Office of Scientific and Technical Information (OSTI.GOV)

May, E. K.; Forristall, R.

2005-11-01

Industrial Solar Technology has assembled a team of experts to develop a large-aperture parabolic trough for the electric power market that moves beyond cost and operating limitations of 1980's designs based on sagged glass reflectors. IST's structurally efficient space frame design will require nearly 50% less material per square meter than a Solel LS-2 concentrator and the new trough will rotate around the focal point. This feature eliminates flexhoses that increase pump power, installation and maintenance costs. IST aims to deliver a concentrator module costing less than $100 per square meter that can produce temperatures up to 400 C. Themore » IST concentrator is ideally suited for application of front surface film reflectors and ensures that US corporations will manufacture major components, except for the high temperature receivers.« less

A comparison between GO/aperture-field and physical-optics methods for offset reflectors

NASA Technical Reports Server (NTRS)

Rahmat-Samii, Y.

1984-01-01

Both geometrical optics (GO)/aperture-field and physical-optics (PO) methods are used extensively in the diffraction analysis of offset parabolic and dual reflectors. An analytical/numerical comparative study is performed to demonstrate the limitations of the GO/aperture-field method for accurately predicting the sidelobe and null positions and levels. In particular, it is shown that for offset parabolic reflectors and for feeds located at the focal point, the predicted far-field patterns (amplitude) by the GO/aperture-field method will always be symmetric even in the offset plane. This, of course, is inaccurate for the general case and it is shown that the physical-optics method can result in asymmetric patterns for cases in which the feed is located at the focal point. Representative numerical data are presented and a comparison is made with available measured data.

Laser-enhanced thermal effect of moderate intensity focused ultrasound on bio-tissues

NASA Astrophysics Data System (ADS)

Zhao, JinYu; Zhang, ShuYi; Shui, XiuJi; Fan, Li

2017-09-01

For avoiding extra-damage to healthy tissues surrounding the focal point during high intensity focused ultrasound (HIFU) treatment in medical therapy, to reduce the ultrasonic intensity outside the focal point is expected. Thus, the heating processes induced by moderate intensity focused ultrasound (MIFU) and enhanced by combined irradiation of laser pulses for bio-tissues are studied in details. For fresh bio-tissues, the enhanced thermal effects by pulsed laser combined with MIFU irradiation are observed experimentally. To explore the mechanisms of these effects, several tissue-mimicking materials composed of agar mixed with graphite powders are prepared and studied for comparison, but the laser-enhanced thermal effects in these mimicking materials are much less than that in the fresh bio-tissues. Therefore, it is suggested that the laser-enhanced thermal effects may be mainly attributed to bio-activities and related photo-bio-chemical effects of fresh tissues.

Micro spectrometer for parallel light and method of use

NASA Technical Reports Server (NTRS)

Park, Yeonjoon (Inventor); Choi, Sang H. (Inventor); King, Glen C. (Inventor); Elliott, James R. (Inventor)

2011-01-01

A spectrometer system includes an optical assembly for collimating light, a micro-ring grating assembly having a plurality of coaxially-aligned ring gratings, an aperture device defining an aperture circumscribing a target focal point, and a photon detector. An electro-optical layer of the grating assembly may be electrically connected to an energy supply to change the refractive index of the electro-optical layer. Alternately, the gratings may be electrically connected to the energy supply and energized, e.g., with alternating voltages, to change the refractive index. A data recorder may record the predetermined spectral characteristic. A method of detecting a spectral characteristic of a predetermined wavelength of source light includes generating collimated light using an optical assembly, directing the collimated light onto the micro-ring grating assembly, and selectively energizing the micro-ring grating assembly to diffract the predetermined wavelength onto the target focal point, and detecting the spectral characteristic using a photon detector.

D3D augmented reality imaging system: proof of concept in mammography.

PubMed

Douglas, David B; Petricoin, Emanuel F; Liotta, Lance; Wilson, Eugene

2016-01-01

The purpose of this article is to present images from simulated breast microcalcifications and assess the pattern of the microcalcifications with a technical development called "depth 3-dimensional (D3D) augmented reality". A computer, head display unit, joystick, D3D augmented reality software, and an in-house script of simulated data of breast microcalcifications in a ductal distribution were used. No patient data was used and no statistical analysis was performed. The D3D augmented reality system demonstrated stereoscopic depth perception by presenting a unique image to each eye, focal point convergence, head position tracking, 3D cursor, and joystick fly-through. The D3D augmented reality imaging system offers image viewing with depth perception and focal point convergence. The D3D augmented reality system should be tested to determine its utility in clinical practice.

Photogrammetry: An available surface characterization tool for solar concentrators. Part 2: Assessment of surfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shortis, M.; Johnston, G.

1997-11-01

In a previous paper, the results of photogrammetric measurements of a number of paraboloidal reflecting surfaces were presented. These results showed that photogrammetry can provide three-dimensional surface characterizations of such solar concentrators. The present paper describes the assessment of the quality of these surfaces as a derivation of the photogrammetrically produced surface coordinates. Statistical analysis of the z-coordinate distribution of errors indicates that these generally conform to a univariate Gaussian distribution, while the numerical assessment of the surface normal vectors on these surfaces indicates that the surface normal deviations appear to follow an approximately bivariate Gaussian distribution. Ray tracing ofmore » the measured surfaces to predict the expected flux distribution at the focal point of the 400 m{sup 2} dish show a close correlation with the videographically measured flux distribution at the focal point of the dish.« less

Single cell manipulation utilizing femtosecond laser-induced shock and stress waves

NASA Astrophysics Data System (ADS)

Hosokawa, Yoichiroh

2017-02-01

When an intense femtosecond laser pulse is focused into a culture medium through an objective lens, an impulsive force is loaded on the cells with generations of the shock and stress waves at the laser focal point. The shock and stress waves were acted to single cells in the vicinity of the laser focal point as an impulsive force. We have applied the impulsive force to manipulate single cells. As the transient intensity of the impulsive force is over 1000 times stronger than the force due to optical tweezers, drastic single manipulation which is difficult by the optical tweezers can be realized. The generation process of the impulsive force and behavior of animal cell after loading the impulsive force were reviewed, and then our original quantification method of the impulsive force utilizing atomic force microscope (AFM) was introduced with its applications for evaluating adhesions between animal cells and between sub-organelles in plant cell.

Method for pulse control in a laser including a stimulated brillouin scattering mirror system

DOEpatents

Dane, C. Brent; Hackel, Lloyd; Harris, Fritz B.

2007-10-23

A laser system, such as a master oscillator/power amplifier system, comprises a gain medium and a stimulated Brillouin scattering SBS mirror system. The SBS mirror system includes an in situ filtered SBS medium that comprises a compound having a small negative non-linear index of refraction, such as a perfluoro compound. An SBS relay telescope having a telescope focal point includes a baffle at the telescope focal point which blocks off angle beams. A beam splitter is placed between the SBS mirror system and the SBS relay telescope, directing a fraction of the beam to an alternate beam path for an alignment fiducial. The SBS mirror system has a collimated SBS cell and a focused SBS cell. An adjustable attenuator is placed between the collimated SBS cell and the focused SBS cell, by which pulse width of the reflected beam can be adjusted.

Stimulated Brillouin scattering mirror system, high power laser and laser peening method and system using same

DOEpatents

Dane, C Brent [Livermore, CA; Hackel, Lloyd [Livermore, CA; Harris, Fritz B [Rocklin, CA

2007-04-24

A laser system, such as a master oscillator/power amplifier system, comprises a gain medium and a stimulated Brillouin scattering SBS mirror system. The SBS mirror system includes an in situ filtered SBS medium that comprises a compound having a small negative non-linear index of refraction, such as a perfluoro compound. An SBS relay telescope having a telescope focal point includes a baffle at the telescope focal point which blocks off angle beams. A beam splitter is placed between the SBS mirror system and the SBS relay telescope, directing a fraction of the beam to an alternate beam path for an alignment fiducial. The SBS mirror system has a collimated SBS cell and a focused SBS cell. An adjustable attenuator is placed between the collimated SBS cell and the focused SBS cell, by which pulse width of the reflected beam can be adjusted.

Relay telescope including baffle, and high power laser amplifier utilizing the same

DOEpatents

Dane, C. Brent; Hackel, Lloyd; Harris, Fritz B.

2006-09-19

A laser system includes an optical path having an intracavity relay telescope with a telescope focal point for imaging an output of the gain medium between an image location at or near the gain medium and an image location at or near an output coupler for the laser system. A kinematic mount is provided within a vacuum chamber, and adapted to secure beam baffles near the telescope focal point. An access port on the vacuum chamber is adapted for allowing insertion and removal of the beam baffles. A first baffle formed using an alignment pinhole aperture is used during alignment of the laser system. A second tapered baffle replaces the alignment aperture during operation and acts as a far-field baffle in which off angle beams strike the baffle a grazing angle of incidence, reducing fluence levels at the impact areas.

Familial temporal lobe epilepsy due to focal cortical dysplasia type IIIa.

PubMed

Fabera, Petr; Krijtova, Hana; Tomasek, Martin; Krysl, David; Zamecnik, Josef; Mohapl, Milan; Jiruska, Premysl; Marusic, Petr

2015-09-01

Focal cortical dysplasia (FCD) represents a common cause of refractory epilepsy. It is considered a sporadic disorder, but its occasional familial occurrence suggests the involvement of genetic mechanisms. Siblings with intractable epilepsy were referred for epilepsy surgery evaluation. Both patients were examined using video-EEG monitoring, MRI examination and PET imaging. They underwent left anteromedial temporal lobe resection. Electroclinical features pointed to left temporal lobe epilepsy and MRI examination revealed typical signs of left-sided hippocampal sclerosis and increased white matter signal intensity in the left temporal pole. PET examination confirmed interictal hypometabolism in the left temporal lobe. Histopathological examination of resected tissue demonstrated the presence FCD type IIIa, i.e. hippocampal sclerosis and focal cortical dysplasia in the left temporal pole. We present a unique case of refractory mesial temporal lobe epilepsy in siblings, characterized by an identical clinical profile and histopathology of FCD type IIIa, who were successfully treated by epilepsy surgery. The presence of such a high concordance between the clinical and morphological data, together with the occurrence of epilepsy and febrile seizures in three generations of the family pedigree points towards a possible genetic nature of the observed FCD type IIIa. Copyright © 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Secondary damage in the spinal cord after motor cortex injury in rats.

PubMed

Weishaupt, Nina; Silasi, Gergely; Colbourne, Frederick; Fouad, Karim

2010-08-01

When neurons within the motor cortex are fatally injured, their axons, many of which project into the spinal cord, undergo wallerian degeneration. Pathological processes occurring downstream of the cortical damage have not been extensively studied. We created a focal forelimb motor cortex injury in rats and found that axons from cell bodies located in the hindlimb motor cortex (spared by the cortical injury) become secondarily damaged in the spinal cord. To assess axonal degeneration in the spinal cord, we quantified silver staining in the corticospinal tract (CST) at 1 week and 4 weeks after the injury. We found a significant increase in silver deposition at the thoracic spinal cord level at 4 weeks compared to 1 week post-injury. At both time points, no degenerating neurons could be found in the hindlimb motor cortex. In a separate experiment, we showed that direct injury of neurons within the hindlimb motor cortex caused marked silver deposition in the thoracic CST at 1 week post-injury, and declined thereafter. Therefore, delayed axonal degeneration in the thoracic spinal cord after a focal forelimb motor cortex injury is indicative of secondary damage at the spinal cord level. Furthermore, immunolabeling of spinal cord sections showed that a local inflammatory response dominated by partially activated Iba-1-positive microglia is mounted in the CST, a viable mechanism to cause the observed secondary degeneration of fibers. In conclusion, we demonstrate that following motor cortex injury, wallerian degeneration of axons in the spinal cord leads to secondary damage, which is likely mediated by inflammatory processes.

Commander islands as the significant point for monitoring some dangerous changes in the Beringia ecosystem

Treesearch

Vladimir Sevostianov

2007-01-01

This paper explores the many natural, historical, and economic reasons the Commander Islands are an essential focal point for field expedition work and finally for conservation projects in the unique ecosystem of the North Pacific. Around the Commander Islands we can find a biologically productive and diverse marine environment. For example, it is one of the richest...

A Comparison of the Cognitive and Personal Development of College-Level Mathematics Students and Developmental Mathematics Students at a Community College

ERIC Educational Resources Information Center

Smith, Bridgett Pressley

2010-01-01

Education is a major focal point of individual justice within a free society as well as a central point of human capital for the world. This study compared the cognitive and personal developmental levels of community college students enrolled in developmental-level mathematics courses to students enrolled in college-level mathematics courses. In…

Paraxial ray solution for liquid-filled variable focus lenses

NASA Astrophysics Data System (ADS)

Wang, Lihui; Oku, Hiromasa; Ishikawa, Masatoshi

2017-12-01

We propose a general solution for determining the cardinal points and effective focal length of a liquid-filled variable focus lens to aid in understanding the dynamic behavior of the lens when the focal length is changed. A prototype of a variable focus lens was fabricated and used to validate the solution. A simplified solution was also presented that can be used to quickly and conveniently calculate the performance of the lens. We expect that the proposed solutions will improve the design of optical systems that contain variable focus lenses, such as machine vision systems with zoom and focus functions.

Absolute OH Number Density Measurements in Lean Fuel-Air Mixtures Excited by a Repetitively Pulsed Nanosecond Discharge

DTIC Science & Technology

2013-01-01

cross section quartz channel with wall thickness of 1.75 mm. Two plane quartz windows are fused to the ends of the channel at Brewster angle (for ~308...ttp :// ar c. ai aa .o rg | D O I: 1 0. 25 14 /6 .2 01 3- 43 2 4 about 1 J/pulse, softly focused over the flame using a lens with a focal...region with an f=550 mm lens . The LIF signal sampling volume was about 100 mm away from the laser focal point, to avoid transition saturation. The

Development of Camera Model and Geometric Calibration/validation of Xsat IRIS Imagery

NASA Astrophysics Data System (ADS)

Kwoh, L. K.; Huang, X.; Tan, W. J.

2012-07-01

XSAT, launched on 20 April 2011, is the first micro-satellite designed and built in Singapore. It orbits the Earth at altitude of 822 km in a sun synchronous orbit. The satellite carries a multispectral camera IRIS with three spectral bands - 0.52~0.60 mm for Green, 0.63~0.69 mm for Red and 0.76~0.89 mm for NIR at 12 m resolution. In the design of IRIS camera, the three bands were acquired by three lines of CCDs (NIR, Red and Green). These CCDs were physically separated in the focal plane and their first pixels not absolutely aligned. The micro-satellite platform was also not stable enough to allow for co-registration of the 3 bands with simple linear transformation. In the camera model developed, this platform stability was compensated with 3rd to 4th order polynomials for the satellite's roll, pitch and yaw attitude angles. With the camera model, the camera parameters such as the band to band separations, the alignment of the CCDs relative to each other, as well as the focal length of the camera can be validated or calibrated. The results of calibration with more than 20 images showed that the band to band along-track separation agreed well with the pre-flight values provided by the vendor (0.093° and 0.046° for the NIR vs red and for green vs red CCDs respectively). The cross-track alignments were 0.05 pixel and 5.9 pixel for the NIR vs red and green vs red CCDs respectively. The focal length was found to be shorter by about 0.8%. This was attributed to the lower operating temperature which XSAT is currently operating. With the calibrated parameters and the camera model, a geometric level 1 multispectral image with RPCs can be generated and if required, orthorectified imagery can also be produced.

Dual-element transducer with phase-inversion for wide depth of field in high-frequency ultrasound imaging.

PubMed

Jeong, Jong Seob

2014-08-05

In high frequency ultrasound imaging (HFUI), the quality of focusing is deeply related to the length of the depth of field (DOF). In this paper, a phase-inversion technique implemented by a dual-element transducer is proposed to enlarge the DOF. The performance of the proposed method was numerically demonstrated by using the ultrasound simulation program called Field-II. A simulated dual-element transducer was composed of a disc- and an annular-type elements, and its aperture was concavely shaped to have a confocal point at 6 mm. The area of each element was identical in order to provide same intensity at the focal point. The outer diameters of the inner and the outer elements were 2.1 mm and 3 mm, respectively. The center frequency of each element was 40 MHz and the f-number (focal depth/aperture size) was two. When two input signals with 0° and 180° phases were applied to inner and outer elements simultaneously, a multi-focal zone was generated in the axial direction. The total -6 dB DOF, i.e., sum of two -6 dB DOFs in the near and far field lobes, was 40% longer than that of the conventional single element transducer. The signal to noise ratio (SNR) was increased by about two times, especially in the far field. The point and cyst phantom simulation were conducted and their results were identical to that of the beam pattern simulation. Thus, the proposed scheme may be a potential method to improve the DOF and SNR in HFUI.

A Plutonium Ceramic Target for MASHA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilk, P A; Shaughnessy, D A; Moody, K J

2004-07-06

We are currently developing a plutonium ceramic target for the MASHA mass separator. The MASHA separator will use a thick plutonium ceramic target capable of tolerating temperatures up to 2000 C. Promising candidates for the target include oxides and carbides, although more research into their thermodynamic properties will be required. Reaction products will diffuse out of the target into an ion source, where they will then be transported through the separator to a position-sensitive focal-plane detector array. Experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments wheremore » the chemical properties of the heaviest elements are studied.« less

Math and Humane Education.

ERIC Educational Resources Information Center

DeRosa, Bill

1986-01-01

Describes an activity designed to improve students' skills at solving mathematical word problems through an awareness of the pet overpopulation problem. Uses the concept of cumulative female offspring as a focal point in assisting students to analyze and work through word problems. (ML)

Utilizing Proverbs as a Focal Point to Cultural Awareness and Communicative Competence: Illustrations from Africa.

ERIC Educational Resources Information Center

Richmond, Edmun B.

1987-01-01

Proposes a model of target- and native-language proverb comparison which can be used to assist proverb analysis in the language curriculum, using examples from Mandinka, a West African language. (Author/CB)

Revision to the SUDAS traffic signal standards : phase 2.

DOT National Transportation Integrated Search

2012-05-01

This report provides a summary of the updates to the traffic signal content within the Iowa Statewide Urban Design and Specifications : (SUDAS) Design Manual Chapter 13 and Standard Specifications Division 8. Major focal points included pole footing ...

Digital focusing of OCT images based on scalar diffraction theory and information entropy

PubMed Central

Liu, Guozhong; Zhi, Zhongwei; Wang, Ruikang K.

2012-01-01

This paper describes a digital method that is capable of automatically focusing optical coherence tomography (OCT) en face images without prior knowledge of the point spread function of the imaging system. The method utilizes a scalar diffraction model to simulate wave propagation from out-of-focus scatter to the focal plane, from which the propagation distance between the out-of-focus plane and the focal plane is determined automatically via an image-definition-evaluation criterion based on information entropy theory. By use of the proposed approach, we demonstrate that the lateral resolution close to that at the focal plane can be recovered from the imaging planes outside the depth of field region with minimal loss of resolution. Fresh onion tissues and mouse fat tissues are used in the experiments to show the performance of the proposed method. PMID:23162717

An Atomic Lens Using a Focusing Hollow Beam

NASA Astrophysics Data System (ADS)

Xia, Yong; Yin, Jian-Ping; Wang, Yu-Zhu

2003-05-01

We propose a new method to generate a focused hollow laser beam by using an azimuthally distributed 2pi-phase plate and a convergent thin lens, and calculate the intensity distribution of the focused hollow beam in free propagation space. The relationship between the waist wo of the incident collimated Gaussian beam and the dark spot size of the focused hollow beam at the focal point, and the relationship between the focal length f of the thin lens and the dark spot size are studied respectively. The optical potential of the blue-detuned focused hollow beam for 85Rb atoms is calculated. Our study shows that when the larger waist w of the incident Gaussian beam and the shorter focal length f of the lens are chosen, we can obtain an extremely small dark spot size of the focused hollow beam, which can be used to form an atomic lens with a resolution of several angstroms.

The correction of aberrations computed in the aperture plane of multifrequency microwave radiometer antennas

NASA Technical Reports Server (NTRS)

Schmidt, R. F.

1984-01-01

An analytical/numerical approach to identifying and correcting the aberrations introduced by a general displacement of the feed from the focal point of a single offset paraboloid antenna used in deployable radiometer systems is developed. A 15 meter reflector with 18 meter focal length is assumed for the analysis, which considers far field radiation pattern quality, focal region fields, and aberrations appearing in the aperture plane. The latter are obtained by ray tracing in the transmit mode and are expressed in terms of optical notation. Attention is given to the physical restraints imposed on corrective elements by real microwave systems and to the intermediate near field aspects of the problem in three dimensions. The subject of wave fronts and caustics in the receive mode is introduced for comparative purposes. Several specific examples are given for aberration reduction at eight beamwidths of scan at a frequency of 1.414 GHz.

Accurate acoustic power measurement for low-intensity focused ultrasound using focal axial vibration velocity

NASA Astrophysics Data System (ADS)

Tao, Chenyang; Guo, Gepu; Ma, Qingyu; Tu, Juan; Zhang, Dong; Hu, Jimin

2017-07-01

Low-intensity focused ultrasound is a form of therapy that can have reversible acoustothermal effects on biological tissue, depending on the exposure parameters. The acoustic power (AP) should be chosen with caution for the sake of safety. To recover the energy of counteracted radial vibrations at the focal point, an accurate AP measurement method using the focal axial vibration velocity (FAVV) is proposed in explicit formulae and is demonstrated experimentally using a laser vibrometer. The experimental APs for two transducers agree well with theoretical calculations and numerical simulations, showing that AP is proportional to the square of the FAVV, with a fixed power gain determined by the physical parameters of the transducers. The favorable results suggest that the FAVV can be used as a valuable parameter for non-contact AP measurement, providing a new strategy for accurate power control for low-intensity focused ultrasound in biomedical engineering.

Generation of a sub-half-wavelength focal spot with purely transverse spin angular momentum

NASA Astrophysics Data System (ADS)

Hang, Li; Fu, Jian; Yu, Xiaochang; Wang, Ying; Chen, Peifeng

2017-11-01

We theoretically demonstrate that optical focus fields with purely transverse spin angular momentum (SAM) can be obtained when a kind of special incident fields is focused by a high numerical aperture (NA) aplanatic lens (AL). When the incident pupil fields are refracted by an AL, two transverse Cartesian components of the electric fields at the exit pupil plane do not have the same order of sinusoidal or cosinoidal components, resulting in zero longitudinal SAMs of the focal fields. An incident field satisfying above conditions is then proposed. Using the Richard-Wolf vectorial diffraction theory, the energy density and SAM density distributions of the tightly focused beam are calculated and the results clearly validate the proposed theory. In addition, a sub-half-wavelength focal spot with purely transverse SAM can be achieved and a flattop energy density distribution parallel to z-axis can be observed around the maximum energy density point.

A comparison of time taken to return to baseline erectile function following focal and whole gland ablative therapies for localized prostate cancer: A systematic review.

PubMed

Faure Walker, Nicholas A; Norris, Joseph M; Shah, Taimur T; Yap, Tet; Cathcart, Paul; Moore, Caroline M; Ahmed, Hashim U; Emberton, Mark; Minhas, Suks

2018-02-01

To systematically review erectile function (EF) outcomes following primary whole gland (WG) and focal ablative therapies for localized prostate cancer to ascertain whether the treatment modality or intended treatment volume affects the time taken to recover baseline EF. A systematic review was performed according to the preferred reporting items for systematic review and meta-analysis statement. Inclusion criteria were men with localized prostate cancer treated with primary, ablative therapy. Primary outcome was the return to baseline EF measured with objective, validated symptoms scores. Secondary outcome was use of phosphodiesterase inhibitors or erectile aids. Meta-analysis was not performed owing to heterogenous outcome measures. Of 222 articles identified in February 2017, 55 studies which reported EF after ablative therapy were identified but only 17 used validated outcome measures and met inclusion criteria. WG cryotherapy was used in 2 studies, WG high-intensity focused ultrasound (HIFU) in 5, focal cryotherapy in 2, focal HIFU in 3, focal phototherapy or laser therapy in 4, vascular-targeted photodynamic therapy in 3, and irreversible electroporation in 2. WG cryotherapy was associated with a significant decline in EF at 6 months with minimal improvement at 36 months. Baseline IIEF-15 of patients undergoing focal HIFU fell 30 points at 1 month but returned to baseline by 6 months. The remaining focal therapies demonstrated minimal or no effect on EF, but the men in these studies had small foci of disease. The review is limited by lack of randomized studies and heterogenous outcome measures. Most studies assessing the outcomes of focal therapy on sexual function were not of high quality, used heterogenous outcomes, and had relatively short follow up, highlighting the need for more robustly designed studies using validated patient reported outcome measures  for comparison. However, FT in general resulted in less effect on EF than WG ablation. Copyright © 2018 Elsevier Inc. All rights reserved.

Three-dimensional particle tracking via tunable color-encoded multiplexing.

PubMed

Duocastella, Martí; Theriault, Christian; Arnold, Craig B

2016-03-01

We present a novel 3D tracking approach capable of locating single particles with nanometric precision over wide axial ranges. Our method uses a fast acousto-optic liquid lens implemented in a bright field microscope to multiplex light based on color into different and selectable focal planes. By separating the red, green, and blue channels from an image captured with a color camera, information from up to three focal planes can be retrieved. Multiplane information from the particle diffraction rings enables precisely locating and tracking individual objects up to an axial range about 5 times larger than conventional single-plane approaches. We apply our method to the 3D visualization of the well-known coffee-stain phenomenon in evaporating water droplets.

Development of the Focal Plane Detection System for the Future Gas-Filled Separator at the Cyclotron Institute

NASA Astrophysics Data System (ADS)

Bertelsen, Erin; Mayorov, Dmitriy; Folden, Charles ``Cody'', III

2015-10-01

A focal plane detection system is being developed for use with the gas-filled separator previously known as SASSYER (Small Angle Separator System at Yale for Evaporation Residues) that will be installed at the Cyclotron Institute at Texas A&M University. This system will be used to study heavy (Z >= 90) elements and features two 60×40 strip double-sided silicon detectors (DSSDs) and accompanying multiplexing read-out electronics. The DSSDs cover an area of 120×40 mm2 and are read-out by fourteen 16-channel multiplexers (Mesytec MUX-16) that perform the function of a preamplifier, shaper, and leading-edge discriminator in one unit. The multiplexers are controlled by four ``MUX drivers,'' each of which serves as a signal bus for multiple MUX-16 boards. The system allows a single 16-channel ADC to read the combined 200 strips of both DSSDs. A four peak source composed of 148Gd, 239Pu, 241Am, and 244Cm was used to characterize the performance of the system, with a preliminary energy resolution of ~ 60 keV measured for the 241Am alphas. This contribution will discuss the work performed in assembly of the test setup, optimization and performance check of the multiplexers, and the preliminary energy and position data collected with the α-source. Present address: Los Alamos National Laboratory, Los Alamos, NM 87545.

Image monitoring of pharmaceutical blending processes and the determination of an end point by using a portable near-infrared imaging device based on a polychromator-type near-infrared spectrometer with a high-speed and high-resolution photo diode array detector.

PubMed

Murayama, Kodai; Ishikawa, Daitaro; Genkawa, Takuma; Sugino, Hiroyuki; Komiyama, Makoto; Ozaki, Yukihiro

2015-03-03

In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis.

Pointing and figure control system for a space-based far-IR segmented telescope

NASA Technical Reports Server (NTRS)

Lau, Kenneth

1993-01-01

A pointing and figure control system for two space-based far-IR telescopes, the 10-20 m Large Deployable Reflector and the 3.6 m Submillimeter Intermediate Mission, is described. The figure maintenance control system is designed to counter the optical elements translational and rotational changes induced by long-term thermal drifts that the support structure may experience. The pointing system applies optical truss to telescope pointing; a laser metrology system is used to transfer pointing informaton from an external fine guidance sensor to the telescope optical boresight, defined by the primary mirror, secondary mirror, and focal plane assembly.

The Unicellular State as a Point Source in a Quantum Biological System

PubMed Central

Torday, John S.; Miller, William B.

2016-01-01

A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific biologic structure or stage. However, such an epigenomic entity exists and its transforming effects can be understood through the obligatory recapitulation of all eukaryotic lifeforms through a zygotic unicellular phase. This requisite biological conjunction can now be properly assessed as the focal point of reconciliation between biology and quantum phenomena, illustrated by deconvoluting complex physiologic traits back to their unicellular origins. PMID:27240413

The Role of Law in Adaptive Governance

EPA Science Inventory

The term “governance” encompasses both governmental and nongovernmental participation in collective choice and action. Law dictates the structure, boundaries, rules, and processes within which governmental action takes place, and in doing so becomes one of the focal points for an...

Options for enhancing the effectiveness of Virginia's safety management system : final report.

DOT National Transportation Integrated Search

1996-02-01

In 1993, Virginia began to formalize the relationships and organizational structure for its Safety Management System (SMS). Although the SMS is no longer a federal requirement, Virginia decided to continue its implementation. The Focal Point for the ...

Richard Wright: Climate of Fear and Violence.

ERIC Educational Resources Information Center

Nnaemeka, Obioma

1992-01-01

In his works, Richard Wright denounces murder while advocating collectivism as an essential ingredient for effecting social change. The short story collection "Uncle Tom's Children" and the novel "Native Son" are the focal points in this analysis of Wright's recurring themes. (SLD)

47 CFR 215.1 - Background.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

47 CFR 215.1 - Background.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

47 CFR 215.1 - Background.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

47 CFR 215.1 - Background.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

47 CFR 215.1 - Background.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Background. 215.1 Section 215.1 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.1 Background. (a) The nuclear electromagnetic...

Spacecraft Alignment Determination and Control for Dual Spacecraft Precision Formation Flying

NASA Technical Reports Server (NTRS)

Calhoun, Philip; Novo-Gradac, Anne-Marie; Shah, Neerav

2017-01-01

Many proposed formation flying missions seek to advance the state of the art in spacecraft science imaging by utilizing precision dual spacecraft formation flying to enable a virtual space telescope. Using precision dual spacecraft alignment, very long focal lengths can be achieved by locating the optics on one spacecraft and the detector on the other. Proposed science missions include astrophysics concepts with spacecraft separations from 1000 km to 25,000 km, such as the Milli-Arc-Second Structure Imager (MASSIM) and the New Worlds Observer, and Heliophysics concepts for solar coronagraphs and X-ray imaging with smaller separations (50m-500m). All of these proposed missions require advances in guidance, navigation, and control (GNC) for precision formation flying. In particular, very precise astrometric alignment control and estimation is required for precise inertial pointing of the virtual space telescope to enable science imaging orders of magnitude better than can be achieved with conventional single spacecraft instruments. This work develops design architectures, algorithms, and performance analysis of proposed GNC systems for precision dual spacecraft astrometric alignment. These systems employ a variety of GNC sensors and actuators, including laser-based alignment and ranging systems, optical imaging sensors (e.g. guide star telescope), inertial measurement units (IMU), as well as microthruster and precision stabilized platforms. A comprehensive GNC performance analysis is given for Heliophysics dual spacecraft PFF imaging mission concept.

Spacecraft Alignment Determination and Control for Dual Spacecraft Precision Formation Flying

NASA Technical Reports Server (NTRS)

Calhoun, Philip C.; Novo-Gradac, Anne-Marie; Shah, Neerav

2017-01-01

Many proposed formation flying missions seek to advance the state of the art in spacecraft science imaging by utilizing precision dual spacecraft formation flying to enable a virtual space telescope. Using precision dual spacecraft alignment, very long focal lengths can be achieved by locating the optics on one spacecraft and the detector on the other. Proposed science missions include astrophysics concepts with spacecraft separations from 1000 km to 25,000 km, such as the Milli-Arc-Second Structure Imager (MASSIM) and the New Worlds Observer, and Heliophysics concepts for solar coronagraphs and X-ray imaging with smaller separations (50m 500m). All of these proposed missions require advances in guidance, navigation, and control (GNC) for precision formation flying. In particular, very precise astrometric alignment control and estimation is required for precise inertial pointing of the virtual space telescope to enable science imaging orders of magnitude better than can be achieved with conventional single spacecraft instruments. This work develops design architectures, algorithms, and performance analysis of proposed GNC systems for precision dual spacecraft astrometric alignment. These systems employ a variety of GNC sensors and actuators, including laser-based alignment and ranging systems, optical imaging sensors (e.g. guide star telescope), inertial measurement units (IMU), as well as micro-thruster and precision stabilized platforms. A comprehensive GNC performance analysis is given for Heliophysics dual spacecraft PFF imaging mission concept.

Determination of Fusion Barrier Distributions from Quasielastic Scattering Cross Sections towards Superheavy Nuclei Synthesis

NASA Astrophysics Data System (ADS)

Tanaka, Taiki; Narikiyo, Yoshihiro; Morita, Kosuke; Fujita, Kunihiro; Kaji, Daiya; Morimoto, Kouji; Yamaki, Sayaka; Wakabayashi, Yasuo; Tanaka, Kengo; Takeyama, Mirei; Yoneda, Akira; Haba, Hiromitsu; Komori, Yukiko; Yanou, Shinya; Jean-Paul Gall, Benoît; Asfari, Zouhair; Faure, Hugo; Hasebe, Hiroo; Huang, Minghui; Kanaya, Jumpei; Murakami, Masashi; Yoshida, Atsushi; Yamaguchi, Takayuki; Tokanai, Fuyuki; Yoshida, Tomomi; Yamamoto, Shoya; Yamano, Yuki; Watanabe, Kenyu; Ishizawa, Satoshi; Asai, Masato; Aono, Ryuji; Goto, Shin-ichi; Katori, Kenji; Hagino, Kouichi

2018-01-01

In order to study the nucleus-nucleus interactions for syntheses of superheavy nuclei, we measured excitation functions for the quasielastic scattering of 48Ca+208Pb, 50Ti+208Pb, and 48Ca+248Cm using the gas-filled-type recoil ion separator GARIS. The quasielastic scattering events were clearly separated from deep-inelastic events by using GARIS and its focal plan detectors, except for high-incident-energy points. The quasielastic barrier distributions were successfully extracted for these systems, and compared with coupled-channels calculations. The results of the calculations indicate that vibrational and rotational excitations of the colliding nuclei, as well as neutron transfers before contact, strongly affect the structure of the barrier distribution. For the reactions of 48Ca+208Pb and 50Ti+208Pb, a local maximum of the barrier distribution occurred at the same energy as the peak of the 2n evaporation cross section of the system. On the other hand, for the hot fusion reaction of 48Ca+248Cm, the 4n evaporation cross section of the system peaks at energies well above the maximum of the barrier distribution. This may be attributed to the deformation of the target nucleus. We argue that these findings can be utilized to locate the optimal energy for future searches for undiscovered superheavy nuclei.

Design of a bullet beam pattern of a micro ultrasound transducer (Conference Presentation)

NASA Astrophysics Data System (ADS)

Roh, Yongrae; Lee, Seongmin

2016-04-01

Ultrasonic imaging transducer is often required to compose a beam pattern of a low sidelobe level and a small beam width over a long focal region to achieve good image resolution. Normal ultrasound transducers have many channels along its azimuth, which allows easy formation of the sound beam into a desired shape. However, micro-array transducers have no control of the beam pattern along their elevation. In this work, a new method is proposed to manipulate the beam pattern by using an acoustic multifocal lens and a shaded electrode on top of the piezoelectric layer. The shading technique split an initial uniform electrode into several segments and combined those segments to compose a desired beam pattern. For a given elevation width and frequency, the optimal pattern of the split electrodes was determined by means of the OptQuest-Nonlinear Program (OQ-NLP) algorithm to achieve the lowest sidelobe level. The requirement to achieve a small beam width with a long focal region was satisfied by employing an acoustic lens of three multiple focuses. Optimal geometry of the multifocal lens such as the radius of curvature and aperture diameter for each focal point was also determined by the OQ-NLP algorithm. For the optimization, a new index was devised to evaluate the on-axis response: focal region ratio = focal region / minimum beam width. The larger was the focal region ratio, the better was the beam pattern. Validity of the design has been verified through fabricating and characterizing an experimental prototype of the transducer.

Muscle fatigue effects can be anticipated to reproduce a movement kinematics learned without fatigue.

PubMed

Monjo, Florian; Forestier, Nicolas

2016-12-17

Muscle fatigue modifies the gain between motor command magnitude and the mechanical muscular response. In other words, post-fatigue, central drives to the muscles must increase to maintain a particular submaximum mechanical output. In this study, we tested the hypothesis that this modified gain can be predicted by the central nervous system (CNS) during discrete ballistic movements. In two separate experiments, subjects were required to perform shoulder flexions in standing and sitting positions at submaximum target peak accelerations. They were assisted with visual feedback informing them on their performance after each trial. Shoulder flexions were performed before and after fatiguing protocols of the focal muscles. Acceleration signals, focal and postural muscle electromyograms (EMGs) were recorded. The results demonstrated that participants were able to reach with precision the target acceleration during the first movements post-fatigue at the cost of significant increase in focal motor command magnitude. Decreased variance of peak accelerations associated with increased focal command variability was observed post-fatigue. During the standing experiment, postural muscle EMGs revealed that anticipatory postural adjustments (APAs) scaled to focal movement acceleration post-fatigue. All these results support that fatigue effects are taken into account during movement planning. Indeed, given that no feedback could enable participants to adjust acceleration during movement, this capacity to anticipate fatigue effects is the exclusive result of feedforward processes. To account for this prediction capacity, we discuss the role of fatigue-related modifications in sensory inputs from the working muscles. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

Making Carbon Emissions Remotely Sensible: Flux Observations of Carbon from an Airborne Laboratory (FOCAL), its Near-Surface Survey of Carbon Gases and Isotopologues on Alaska's North Slope

NASA Astrophysics Data System (ADS)

Dobosy, R.; Dumas, E. J.; Sayres, D. S.; Healy, C. E.; Munster, J. B.; Baker, B.; Anderson, J. G.

2014-12-01

Detailed process-oriented study of the mechanisms of conversion in the Arctic of fossil carbon to atmospheric gas is progressing, but necessarily limited to a few point locations and requiring detailed subsurface measurements inaccessible to remote sensing. Airborne measurements of concentration, transport and flux of these carbon gases at sufficiently low altitude to reflect surface variations can tie such local measurements to remotely observable features of the landscape. Carbon dioxide and water vapor have been observable for over 20 years from low-altitude small aircraft in the Arctic and elsewhere. Methane has been more difficult, requiring large powerful aircraft or limited flask samples. Recent developments in spectroscopy, however, have reduced the power and weight required to measure methane at rates suitable for eddy-covariance flux estimates. The Flux Observations of Carbon from an Airborne Laboratory (FOCAL) takes advantage of Integrated Cavity-Output Spectroscopy (ICOS) to measure CH4, CO2, and water vapor in a new airborne system. The system, moreover, measures these gases' stable isotopologues every two seconds or faster helping to separate thermogenic from biogenic emissions. Paired with the Best Airborne Turbulence (BAT) probe developed for small aircraft by NOAA's Air Resources Laboratory and a light twin-engine aircraft adapted by Aurora Flight Sciences Inc., the FOCAL measures at 6 m spacing, covering 100 km in less than 30 minutes. It flies between 10 m and 50 m above ground interspersed with profiles to the top of the boundary layer and beyond. This presentation gives an overview of the magnitude and variation in fluxes and concentrations of CH4, CO2, and H2O with space, time, and time of day in a spatially extensive survey, more than 7500 km total in 15 flights over roughly a 100 km square during the month of August 2013. An extensive data set such as this at low altitude with high-rate sampling addresses features that repeat on 1 km scale or smaller such as thermokarst lakes as well as landscape changes on the 100 km scale.

Genetic heterogeneity in families with non-epidermolytic palmar plantar keratosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spurr, N.K.; Kelshell, D.P.; Stevens, H.

1994-09-01

Following reports of linkage close to the keratin gene cluster in families with tylosis and the detection of mutations in the keratin 9 gene cosegregating in families with epidermolytic palmar plantar keratoderma (EPPK, and EPPK associated with breast and ovarian cancer), we have identified families with three phenotypically distinct forms of non-epidermolytic keratosis with either punctate, diffuse or focal keratoderma, one with diffuse lesions and one with punctate and malignancies. Initially we typed these families with 17q markers close to the keratin gene cluster; this included a dinucleotide repeat marker within the keratin 9 gene. Two point linkage analysis ofmore » the focal keratoderma family showed a positive lod score of 3.2 at a theta of 0 from the marker D17S855. The lod score for the diffuse family was -6.0 at a theta of 0.05 from the marker D17S776. The second focal keratoderma family showed a haplotype consistent with linkage to 17q close to the keratin gene cluster. A second keratin gene cluster has been mapped in humans on 12q, and we decided to test the unlinked diffuse and punctate keratoderma families with markers in that region. We used the markers: D12S87-D12S85-D12S368-D12S96-D12S90. Linkage analysis of the diffuse family gave a lod score of 3.1 at a theta of 0 from the marker D12S368. Currently studies are underway to look for mutations in specific keratin genes in the clusters on 17q and 12q that segregate with the observed phenotypes. The punctate keratoderma family gave lod scores of -3.9 at a theta of 0.55 with D17S855 and -6.0 at a theta of 0.05 with D12S90/D12S83. This would lead us to the conclusion that a separate susceptibility locus must exist for the punctate family associated with malignancy. Investigations of candidate regions are in progress.« less

Focal nodular hyperplasia coexistent with hepatoblastoma in a 36-d-old infant

PubMed Central

Gong, Ying; Chen, Lian; Qiao, Zhong-Wei; Ma, Yang-Yang

2015-01-01

Focal nodular hyperplasia (FNH) is a benign hepatic tumor characterized by hepatocyte hyperplasia and a central stellate scar. The association of FNH with other hepatic lesions, such as adenomas, hemangiomas and hepatocellular carcinoma, has been previously reported, but FNH associated with another hepatic tumor is rare in infants. Here we report a case of FNH coexistent with hepatoblastoma in a 36-d-old girl. Computed tomography (CT) imaging showed an ill-delineated, inhomogeneous enhanced mass with a central star-like scar in the right lobe of the liver. The tumor showed early mild enhancement at the arterial phase (from 40HU without contrast to 52HU at the arterial phase), intense enhancement at the portal phase (87.7HU) and 98.1HU in the 3-min delay scan. A central scar in the tumor presented as low density on non-contrast CT and slightly enhanced at delayed contrast-enhanced scanning. This infant underwent surgical resection of the tumor. Histopathology demonstrated typical FNH coexistent with a focal hepatoblastoma, which showed epithelioid tumor cells separated by proliferated fibrous tissue. PMID:25624742

Focal nodular hyperplasia coexistent with hepatoblastoma in a 36-d-old infant.

PubMed

Gong, Ying; Chen, Lian; Qiao, Zhong-Wei; Ma, Yang-Yang

2015-01-21

Focal nodular hyperplasia (FNH) is a benign hepatic tumor characterized by hepatocyte hyperplasia and a central stellate scar. The association of FNH with other hepatic lesions, such as adenomas, hemangiomas and hepatocellular carcinoma, has been previously reported, but FNH associated with another hepatic tumor is rare in infants. Here we report a case of FNH coexistent with hepatoblastoma in a 36-d-old girl. Computed tomography (CT) imaging showed an ill-delineated, inhomogeneous enhanced mass with a central star-like scar in the right lobe of the liver. The tumor showed early mild enhancement at the arterial phase (from 40HU without contrast to 52HU at the arterial phase), intense enhancement at the portal phase (87.7HU) and 98.1HU in the 3-min delay scan. A central scar in the tumor presented as low density on non-contrast CT and slightly enhanced at delayed contrast-enhanced scanning. This infant underwent surgical resection of the tumor. Histopathology demonstrated typical FNH coexistent with a focal hepatoblastoma, which showed epithelioid tumor cells separated by proliferated fibrous tissue.

Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters

NASA Technical Reports Server (NTRS)

Strangman, Gary; Franceschini, Maria Angela; Boas, David A.; Sutton, J. P. (Principal Investigator)

2003-01-01

Near-infrared spectroscopy (NIRS) can be used to noninvasively measure changes in the concentrations of oxy- and deoxyhemoglobin in tissue. We have previously shown that while global changes can be reliably measured, focal changes can produce erroneous estimates of concentration changes (NeuroImage 13 (2001), 76). Here, we describe four separate sources for systematic error in the calculation of focal hemoglobin changes from NIRS data and use experimental methods and Monte Carlo simulations to examine the importance and mitigation methods of each. The sources of error are: (1). the absolute magnitudes and relative differences in pathlength factors as a function of wavelength, (2). the location and spatial extent of the absorption change with respect to the optical probe, (3). possible differences in the spatial distribution of hemoglobin species, and (4). the potential for simultaneous monitoring of multiple regions of activation. We found wavelength selection and optode placement to be important variables in minimizing such errors, and our findings indicate that appropriate experimental procedures could reduce each of these errors to a small fraction (<10%) of the observed concentration changes.

Perpetuation of torsade de pointes in heterogeneous hearts: competing foci or re-entry?

PubMed

Vandersickel, Nele; de Boer, Teun P; Vos, Marc A; Panfilov, Alexander V

2016-12-01

The underlying mechanism of torsade de pointes (TdP) remains of debate: perpetuation may be due to (1) focal activity or (2) re-entrant activity. The onset of TdP correlates with action potential heterogeneities in different regions of the heart. We studied the mechanism of perpetuation of TdP in silico using a 2D model of human cardiac tissue and an anatomically accurate model of the ventricles of the human heart. We found that the mechanism of perpetuation TdP depends on the degree of heterogeneity. If the degree of heterogeneity is large, focal activity alone can sustain a TdP, otherwise re-entrant activity emerges. This result can help to understand the relationship between the mechanisms of TdP and tissue properties and may help in developing new drugs against it. Torsade de pointes (TdP) can be the consequence of cardiac remodelling, drug effects or a combination of both. The mechanism underlying TdP is unclear, and may involve triggered focal activity or re-entry. Recent work by our group has indicated that both cases may exist, i.e. TdPs induced in the chronic atrioventricular block (CAVB) dog model may have a focal origin or are due to re-entry. Also it was found that heterogeneities might play an important role. In the current study we have used computational modelling to further investigate the mechanisms involved in TdP initiation and perpetuation, especially in the CAVB dog model, by the addition of heterogeneities with reduced repolarization reserve in comparison with the surrounding tissue. For this, the TNNP computer model was used for computations. We demonstrated in 2D and 3D simulations that ECGs with the typical TdP morphology can be caused by both multiple competing foci and re-entry circuits as a result of introduction of heterogeneities, depending on whether the heterogeneities have a large or a smaller reduced repolarization reserve in comparison with the surrounding tissue. Large heterogeneities can produce ectopic TdP, while smaller heterogeneities will produce re-entry-type TdP. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

Direct generation of abruptly focusing vortex beams using a 3/2 radial phase-only pattern.

PubMed

Davis, Jeffrey A; Cottrell, Don M; Zinn, Jonathan M

2013-03-20

Abruptly focusing Airy beams have previously been generated using a radial cubic phase pattern that represents the Fourier transform of the Airy beam. The Fourier transform of this pattern is formed using a system length of 2f, where f is the focal length of the Fourier transform lens. In this work, we directly generate these abruptly focusing Airy beams using a 3/2 radial phase pattern encoded onto a liquid crystal display. The resulting optical system is much shorter. In addition, we can easily produce vortex patterns at the focal point of these beams. Experimental results match theoretical predictions.

Public transit to public lands : the nature express.

DOT National Transportation Integrated Search

2017-05-01

Access to leisure by public transportation has not been studied in great detail, at least in the United States. The Northeastern Illinois region with the City of Chicago (in Cook County) as the focal point is home to the third largest public transpor...

42 CFR 460.6 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... a facility which includes a primary care clinic, and areas for therapeutic recreation, restorative therapies, socialization, personal care, and dining, and which serves as the focal point for coordination... ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Basis...

42 CFR 460.6 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... a facility which includes a primary care clinic, and areas for therapeutic recreation, restorative therapies, socialization, personal care, and dining, and which serves as the focal point for coordination... ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Basis...

42 CFR 460.6 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... a facility which includes a primary care clinic, and areas for therapeutic recreation, restorative therapies, socialization, personal care, and dining, and which serves as the focal point for coordination... ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Basis...

The Federal Employees' Compensation Act.

ERIC Educational Resources Information Center

Nordlund, Willis J.

1991-01-01

The 1916 Federal Employees' Compensation Act is still the focal point around which the federal workers compensation program works today. The program has gone through many changes on its way to becoming a modern means of compensating workers for job-related injury, disease, and death. (Author)

Chariots for Apollo: A History of Manned Lunar Spacecraft

NASA Technical Reports Server (NTRS)

Brooks, C. G.; Grimwood, J. M.; Swenson, L. S., Jr.

1979-01-01

Beginning with the challenges presented by Sputnik 1 in 1957, and the formation of NASA, the apollo lunar exploration program is reviewed through Apollo Flight 11. The focal points are the spacecraft including the command and service modules, and the lunar module.

47 CFR 215.2 - Assignment of responsibilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Assignment of responsibilities. 215.2 Section 215.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.2 Assignment of responsibilities...

47 CFR 215.2 - Assignment of responsibilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Assignment of responsibilities. 215.2 Section 215.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.2 Assignment of responsibilities...

47 CFR 215.2 - Assignment of responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Assignment of responsibilities. 215.2 Section 215.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.2 Assignment of responsibilities...

47 CFR 215.2 - Assignment of responsibilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Assignment of responsibilities. 215.2 Section 215.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.2 Assignment of responsibilities...

47 CFR 215.2 - Assignment of responsibilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Assignment of responsibilities. 215.2 Section 215.2 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL FEDERAL GOVERNMENT FOCAL POINT FOR ELECTROMAGNETIC PULSE (EMP) INFORMATION § 215.2 Assignment of responsibilities...

Taylorism and the Logic of Learning Outcomes

ERIC Educational Resources Information Center

Stoller, Aaron

2015-01-01

This essay examines the shared philosophical foundations of Fredrick W. Taylor's scientific management principles and the contemporary learning outcomes movement (LOM). It analyses the shared philosophical ground between the focal point of Taylor's system--"the task"--and the conceptualization and deployment of "learning…

Study of efficacy of esthetic High-Intensity Focused Ultrasound system on Iranian skin for reducing the laxity and wrinkles of aging.

PubMed

Saket, Parvaneh; Shobeihi, Shobeir; Mehrdadi, Soroush

2017-09-01

Ultrasound is a mechanical wave that transmitted in a straight line and it can be focused at frequencies of 1-7 MHz with a high degree of precision. An important aspect of HIFU is that damaging focal point is located several millimeters below the surface of the skin and tissue above and below the focal point remains unaffected. Due to absorption of this energy, temperature of tissue rises to more than 60°C and this stimulates the cells for collagen production and tissue rejuvenation. To evaluate the clinical efficacy and safety of High-Intensity Focused Ultrasound on Skin Laxity and wrinkles. The study involved 22 women aged 35-62 with skin type II-IV. HIFU device with three transducers was employed. Various focal depths with different energies were used in accordance with skin thickness. Improvement for seven regions of face and whole face were evaluated by two dermatologists and patients 3 months after treatment. All of the patients completed the study. Three months after treatment, there was a highly statistical improvement in skin laxity for all of the patients. Also, the average percentage of improvement by doctor's opinion and patients was 58% and 60%, respectively. The experimental data obtained from dermatologists and patients showed that HIFU appears to be a safe and effective modality for skin laxity treatment. © 2017 Wiley Periodicals, Inc.

Effects of laser acupoint irradiation on energy metabolism of brain tissue of rats with cerebral ischemia-reperfusion

NASA Astrophysics Data System (ADS)

Xiong, Guoxin; Li, Xinzhong

2017-12-01

The protective effect and mechanism of low-intensity laser acupoint irradiation on focal cerebral ischemia-reperfusion (CIR) injury in rats were investigated. Male Sprague-Dawley rats were randomly divided into a sham group, a CIR model (model) group, and a model plus laser irradiation (laser) group. The focal CIR model was induced by middle cerebral artery occlusion in all except the rats in the sham group. After modeling, the Baihui, Mingmen, and left Zusanli points of the rats in the laser group were irradiated with 15 mW using a semiconductor laser, and each point was irradiated for 15 min once a day for 7 d. The treatments used in the sham and model groups were the same as in the laser group except that the laser output power was zero. After treatment, the expressions of serum superoxide dismutase (SOD) activity and serum malonaldehyde (MDA) content, the expression of growth-associated protein (GAP-43), the activities of succinic dehydrogenase and lactic dehydrogenase in brain tissue, were measured. The results showed that acupoint irradiation with a semiconductor laser can improve energy metabolism, enhance the expression of GAP-43, increase the levels of expression of serum SOD, and decrease the serum MDA content in a rat model of focal CIR, suggesting the mechanism for reduction of CIR injury.

Optimizing focal plane electric field estimation for detecting exoplanets

NASA Astrophysics Data System (ADS)

Groff, T.; Kasdin, N. J.; Riggs, A. J. E.

Detecting extrasolar planets with angular separations and contrast levels similar to Earth requires a large space-based observatory and advanced starlight suppression techniques. This paper focuses on techniques employing an internal coronagraph, which is highly sensitive to optical errors and must rely on focal plane wavefront control techniques to achieve the necessary contrast levels. To maximize the available science time for a coronagraphic mission we demonstrate an estimation scheme using a discrete time Kalman filter. The state estimate feedback inherent to the filter allows us to minimize the number of exposures required to estimate the electric field. We also show progress including a bias estimate into the Kalman filter to eliminate incoherent light from the estimate. Since the exoplanets themselves are incoherent to the star, this has the added benefit of using the control history to gain certainty in the location of exoplanet candidates as the signal-to-noise between the planets and speckles improves. Having established a purely focal plane based wavefront estimation technique, we discuss a sensor fusion concept where alternate wavefront sensors feedforward a time update to the focal plane estimate to improve robustness to time varying speckle. The overall goal of this work is to reduce the time required for wavefront control on a target, thereby improving the observatory's planet detection performance by increasing the number of targets reachable during the lifespan of the mission.

Interactions for pollinator visitation and their consequences for reproduction in a plant community

NASA Astrophysics Data System (ADS)

Hegland, Stein Joar; Totland, Ørjan

2012-08-01

Competition and facilitation in species interactions attract much attention in ecology, but their relative importance has seldom been evaluated in a community context. We assessed competitive and facilitative interactions for pollinator visitation among co-flowering species in a plant community, investigated the subsequent consequences for plant reproduction, and investigated whether effects could be trait-based. We removed the flowers of two species attractive to pollinators, in two separate experiments and assessed the effects on pollinator visitation rates and components of reproductive success in 11 co-flowering focal herb species. Overall, most focal species appear not to interact with the removal species with respect to pollinator visitation and subsequent reproduction (neutral interactions). Three focal species in the community had significantly higher reproductive responses (fruit production and seed weight) in the presence of the attractive removal species (facilitative interactions), but species interaction effects were less pronounced in species' flower visitation rates. A community-wide meta-analysis demonstrated that the two experiments did not have a significant effect on either facilitation or competition, and that there was no overall correlation between effect sizes for visitation and reproduction. Based on species-specific responses, it seems likely that floral traits such as similar flower colors contribute to interspecific facilitation of pollinator visitation and, in particular, that high pollinator dependence for plant reproduction, and associated pollen limitation, may contribute to subsequent interaction effects on reproduction in the focal species.

High-resolution velocimetry in energetic tidal currents using a convergent-beam acoustic Doppler profiler

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sellar, Brian; Harding, Samuel F.; Richmond, Marshall C.

An array of convergent acoustic Doppler velocimeters has been developed and tested for the high resolution measurement of three-dimensional tidal flow velocities in an energetic tidal site. This configuration has been developed to increase spatial resolution of velocity measurements in comparison to conventional acoustic Doppler profilers (ADPs) which characteristically use diverging acoustic beams emanating from a single instrument. This is achieved using converging acoustic beams with a sample volume at the focal point of 0.03 m 3. The array is also able to simultaneously measure three-dimensional velocity components in a profile throughout the water column, and as such is referredmore » to herein as a converging-beam acoustic Doppler profiler (CADP). Mid-depth profiling is achieved through integration of the sensor platform with the operational Alstom 1MW DeepGen-IV Tidal Turbine. This proof-of-concept paper outlines system configuration and comparison to measurements provided by co-installed reference instrumentation. Comparison of CADP to standard ADP velocity measurements reveals a mean difference of 8 mm/s, standard deviation of 18 mm/s, and order-of-magnitude reduction in realizable length-scale. CADP focal point measurements compared to a proximal single-beam reference show peak cross-correlation coefficient of 0.96 over 4.0 s averaging period and a 47% reduction in Doppler noise. The dual functionality of the CADP as a profiling instrument with a high resolution focal point make this configuration a unique and valuable advancement in underwater velocimetry enabling improved turbulence, resource and structural loading quantification and validation of numerical simulations. Alternative modes of operation have been implemented including noise-reducing bi-static sampling. Since waves are simultaneously measured it is expected that derivatives of this system will be a powerful tool in wave-current interaction studies.« less

The Teaching of Global Environmental Problems According to the Constructivist Approach: As a Focal Point of the Problem and the Availability of Concept Cartoons

ERIC Educational Resources Information Center

Oluk, Sami; Ozalp, Isilay

2007-01-01

In this study, with selecting the focusing point of the problem as the availability of cartoons, the teaching of global environmental problems according to the constructivist theory is investigated on the 7th graders in rural areas. This study is restricted with the global warming (G), ozone depletion (O) and the acid rain (A) problems. In the…

A novel dual-color bifocal imaging system for single-molecule studies.

PubMed

Jiang, Chang; Kaul, Neha; Campbell, Jenna; Meyhofer, Edgar

2017-05-01

In this paper, we report the design and implementation of a dual-color bifocal imaging (DBI) system that is capable of acquiring two spectrally distinct, spatially registered images of objects located in either same or two distinct focal planes. We achieve this by separating an image into two channels with distinct chromatic properties and independently focusing both images onto a single CCD camera. The two channels in our device are registered with subpixel accuracy, and long-term stability of the registered images with nanometer-precision was accomplished by reducing the drift of the images to ∼5 nm. We demonstrate the capabilities of our DBI system by imaging biomolecules labeled with spectrally distinct dyes and micro- and nano-sized spheres located in different focal planes.

Radiology of pneumonia.

PubMed

Gharib, A M; Stern, E J

2001-11-01

Infection of the lower respiratory tract, acquired by way of the airways and confined to the lung parenchyma and airways, typically presents radiologically as one of three patterns: (1) focal nonsegmental or lobar pneumonia, (2) multifocal bronchopneumonia or lobular pneumonia, and (3) focal or diffuse "interstitial" pneumonia. These patterns can be useful in identifying the etiological organism in the appropriate clinical setting. To serve the purpose of this article, these patterns are used as the primary method of classification of pulmonary infections caused by different organisms. Mycobacterial and fungal pulmonary infections are reviewed separately because of their wide range of radiographic appearance that depend on the stage of the disease at presentation. This article discusses the clinical and radiographic features of the most common causes of pneumonia, primarily in the adult population of the United States.

Performance and cost benefits associated with nonimaging secondary concentrators used in point-focus dish solar thermal applications

NASA Astrophysics Data System (ADS)

Ogallagher, J.; Winston, R.

1987-09-01

Using nonimaging secondary concentrators in point-focus applications may permit the development of more cost-effective concentrator systems by either improving performance or reducing costs. Secondaries may also increase design flexibility. The major objective of this study was to develop as complete an understanding as possible of the quantitative performance and cost effects associated with deploying nonimaging secondary concentrators at the focal zone of point-focus solar thermal concentrators. A performance model was developed that uses a Monte Carlo ray-trace procedure to determine the focal plane distribution of a paraboloidal primary as a function of optical parameters. It then calculates the corresponding optimized concentration and thermal efficiency as a function of temperature with and without the secondary. To examine the potential cost benefits associated with secondaries, a preliminary model for the rational optimization of performance versus cost trade-offs was developed. This model suggests a possible 10 to 20 percent reduction in the cost of delivered energy when secondaries are used. This is a lower limit, and the benefits may even be greater if using a secondary permits the development of inexpensive primary technologies for which the performance would not otherwise be viable.

Development and Beam-Shape Analysis of an Integrated Fiber-Optic Confocal Probe for High-Precision Central Thickness Measurement of Small-Radius Lenses

PubMed Central

Sutapun, Boonsong; Somboonkaew, Armote; Amarit, Ratthasart; Chanhorm, Sataporn

2015-01-01

This work describes a new design of a fiber-optic confocal probe suitable for measuring the central thicknesses of small-radius optical lenses or similar objects. The proposed confocal probe utilizes an integrated camera that functions as a shape-encoded position-sensing device. The confocal signal for thickness measurement and beam-shape data for off-axis measurement can be simultaneously acquired using the proposed probe. Placing the probe’s focal point off-center relative to a sample’s vertex produces a non-circular image at the camera’s image plane that closely resembles an ellipse for small displacements. We were able to precisely position the confocal probe’s focal point relative to the vertex point of a ball lens with a radius of 2.5 mm, with a lateral resolution of 1.2 µm. The reflected beam shape based on partial blocking by an aperture was analyzed and verified experimentally. The proposed confocal probe offers a low-cost, high-precision technique, an alternative to a high-cost three-dimensional surface profiler, for tight quality control of small optical lenses during the manufacturing process. PMID:25871720

Formation Flying of Components of a Large Space Telescope

NASA Technical Reports Server (NTRS)

Mettler, Edward; Quadrelli, Marco; Breckenridge, William

2009-01-01

A conceptual space telescope having an aperture tens of meters wide and a focal length of hundreds of meters would be implemented as a group of six separate optical modules flying in formation: a primary-membrane-mirror module, a relay-mirror module, a focal-plane-assembly module containing a fast steering mirror and secondary and tertiary optics, a primary-mirror-figure-sensing module, a scanning-electron-beam module for controlling the shape of the primary mirror, and a sunshade module. Formation flying would make it unnecessary to maintain the required precise alignments among the modules by means of an impractically massive rigid structure. Instead, a control system operating in conjunction with a metrology system comprising optical and radio subsystems would control the firing of small thrusters on the separate modules to maintain the formation, thereby acting as a virtual rigid structure. The control system would utilize a combination of centralized- and decentralized-control methods according to a leader-follower approach. The feasibility of the concept was demonstrated in computational simulations that showed that relative positions could be maintained to within a fraction of a millimeter and orientations to within several microradians.

Laser machining-- a status report

Treesearch

C. W. McMillin

1972-01-01

The laser (an acronym for Light Amplification by Stimulated Emission of Radiation) provides a source of intense optical radiation. This energy can be focused to a very small diameter. At even moderate power levels, therefore, the energy at the focal point is sufficient to vaporize most materials.

Meet the Alpha-Pets.

ERIC Educational Resources Information Center

Zitlaw, Jo Ann Bruce; Frank, Cheryl Standish

1985-01-01

"Alpha-Pets" are the focal point of an integrated, multidisciplinary curriculum. Each pet is featured for a week in a vocabulary-rich story and introduces related activities beginning with the featured letter, such as the four food groups during Freddie Fish's week or universe during Ulysses Unicorn's week. (MT)

Compact range for variable-zone measurements

DOEpatents

Burnside, Walter D.; Rudduck, Roger C.; Yu, Jiunn S.

1988-08-02

A compact range for testing antennas or radar targets includes a source for directing energy along a feedline toward a parabolic reflector. The reflected wave is a spherical wave with a radius dependent on the distance of the source from the focal point of the reflector.

76 FR 21908 - Statement of Organization, Functions, and Delegations of Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... areas of traditional and new media, including Web initiatives such as social media supported by innovative, increasingly mobile technologies; media relations; public information campaigns; and speechwriting. Serves as CMS' focal point in all activities related to the media. Provides consultation, advice...

32 CFR 85.6 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... serve as the focal point for all health promotion program issues and to integrate the activities of the... prevention and cessation, physical fitness, nutrition, stress management, alcohol and drug abuse, and early.... (v) As part of routine physical and dental examinations and at other appropriate times, health care...

Compact range for variable-zone measurements

DOEpatents

Burnside, Walter D.; Rudduck, Roger C.; Yu, Jiunn S.

1988-01-01

A compact range for testing antennas or radar targets includes a source for directing energy along a feedline toward a parabolic reflector. The reflected wave is a spherical wave with a radius dependent on the distance of the source from the focal point of the reflector.

In Defense of the Vendors

ERIC Educational Resources Information Center

Irwin, G. Brockett

1975-01-01

The problems that are encountered when cooperation breaks down between the industrial source operator and the pollution control equipment vendor are examined. The focal point of this examination is the study of defenses available to the equipment vendor when industrial source operators refuse to cooperate. (Author/BT)

76 FR 19376 - Statement of Organizations, Functions, and Delegations of Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... safety mission. These outside groups include academic organizations, private organizations, and other Federal Agencies. 3. Coordinates the access to large databases for pharmacoepidemiologic and..., procedures, training, and security or databases available to OSE. 3. Acts as focal point for all hardware...

Stress analysis of the space telescope focal plane structure joint

NASA Technical Reports Server (NTRS)

Foster, W. A., Jr.; Shoemaker, W. L.

1985-01-01

Two major efforts were begun concerning the Space Telescope focal plane structure joint. The 3-D solid finite element modeling of the bipod flexure plate was carried out. Conceptual models were developed for the load transfer through the three major bolts to the flexure plate. The flexure plate drawings were reconstructed using DADAM for the purpose of developing a file from which the coordinates of any point on the flexure plate could be determined and also to locate the attachment points of the various components which connect with the flexure plate. For modeling convenience the CADAM drawing of the flexure plate has been divided into several regions which will be subdivided into finite elements using MSGMESH, which is a finite element mesh generator available with MSC/NASTRAN. In addition to the CADAM work on the flexure plate, an effort was also begun to develop computer aided drawings of the peripheral beam which will be used to assist in modeling the connection between it and the flexure plate.

Applications of two-photon fluorescence microscopy in deep-tissue imaging

NASA Astrophysics Data System (ADS)

Dong, Chen-Yuan; Yu, Betty; Hsu, Lily L.; Kaplan, Peter D.; Blankschstein, D.; Langer, Robert; So, Peter T. C.

2000-07-01

Based on the non-linear excitation of fluorescence molecules, two-photon fluorescence microscopy has become a significant new tool for biological imaging. The point-like excitation characteristic of this technique enhances image quality by the virtual elimination of off-focal fluorescence. Furthermore, sample photodamage is greatly reduced because fluorescence excitation is limited to the focal region. For deep tissue imaging, two-photon microscopy has the additional benefit in the greatly improved imaging depth penetration. Since the near- infrared laser sources used in two-photon microscopy scatter less than their UV/glue-green counterparts, in-depth imaging of highly scattering specimen can be greatly improved. In this work, we will present data characterizing both the imaging characteristics (point-spread-functions) and tissue samples (skin) images using this novel technology. In particular, we will demonstrate how blind deconvolution can be used further improve two-photon image quality and how this technique can be used to study mechanisms of chemically-enhanced, transdermal drug delivery.

Experimental validation of a newly designed 6 degrees of freedom scanning laser head: Application to three-dimensional beam structure

DOE Office of Scientific and Technical Information (OSTI.GOV)

Di Maio, D., E-mail: dario.dimaio@bristol.ac.uk; Copertaro, E.

2013-12-15

A new scanning laser head is designed to use single Laser Doppler Vibrometer (LDV) for performing measurements up to 6 degrees of freedom (DOF) at a target. The scanning head is supported by a rotating hollow shaft, which allows the laser beam to travel up to the scanning head from an opposite direction where an LDV is set up. The scanning head is made of a set of two mirrors, which deflects the laser beam with an angle so that the rotation of the scanning head produces a conical scan. When measurements are performed at the focal point of themore » conical scan then three translational vibration components can be measured, otherwise the very small circle scan, before and after the focal point, can measure up to 6 degrees of freedom, including three translations and three rotations. This paper presents the 6DOF scanning head and the measurements of 3D operational deflection shapes of a test structure.« less

Influence of Radiographic Positioning on Canine Sacroiliac and Lumbosacral Angle Measurements.

PubMed

Jones, Susan; Savage, Mason; Naughton, Brian; Singh, Susheela; Robertson, Ian; Roe, Simon C; Marcellin-Little, Denis J; Mathews, Kyle G

2018-01-01

 To evaluate the influence of radiographic malpositioning on canine sacroiliac and lumbosacral inclination angles.  Using canine cadavers, lateral pelvic radiographs were acquired with the radiographic beam in a neutral position and then rotated 5, 10 and 15° to mimic rotational malpositioning. The focal point of the beam was then focused over the abdomen and again over mid-diaphysis of the femur to mimic an abdominal or femoral radiographic study.  Five degrees of rotational malpositioning did not influence measurements of sacroiliac or lumbosacral inclination, but malpositioning by more than 5° led to a significant decrease in both sacroiliac and lumbosacral angles. Moving the focal point to the femur significantly decreased the measured lumbosacral angle. Abdominally centred radiographs had no effect on lumbosacral and sacroiliac angle measurements.  When evaluating canine lumbosacral and sacroiliac angles radiographically, pelvic rotation of more than 5° should be avoided as should the use of lateral radiographs centred over the femur. Schattauer GmbH Stuttgart.

IAL SPACE: A test laboratory for the ISO cryogenic payload

NASA Technical Reports Server (NTRS)

Cucchiaro, A.; Henrist, M.; Macau, J. P.; Ninane, N.; Blanpain, R.

1990-01-01

The ESA Infrared Space Observatory (ISO) satellite is a 3 axes pointed platform designed to make accurate pointed observations of astronomical objects and sources in the wavelength range between 2.5 and 200 microns. ISO is composed of a service module and a payload module which is a large cylindrical vacuum vessel. The vessel is in fact a cryostat (capacity of 2250 l of liquid He II) which contains the telescope and the four focal scientific instruments. The latter being cooled up to a temperature less than 4 K. The qualification of the payload requires the measurement respectively of: the image quality of the telescope through wave front error (WFE) measurements; and the optical alignment of the scientific instruments with respect to the telescope axis and the telescope focus, and this under cryogenic conditions. Consequently, since 1988, the FOCAL 5 IAL Space facility has been upgraded in order to perform the cryogenic optical tests of the ISO optical subsystems.

Status of national diabetes programmes in the Americas.

PubMed Central

White, F.; Nanan, D.

1999-01-01

Reported are the responses in the latter half of 1997 of all ministries of health in the Region of the Americas to the Declaration of the Americas on Diabetes, which was adopted by the Directing Council of the Pan American Health Organization (PAHO) in 1996 as a basis for national programme development in diabetes. The short-term targets were the designation of national focal points, the preparation of national estimates of the disease burden, and the development and implementation of national strategies and plans to deal with diabetes. The survey found that most countries recognized diabetes as a significant public health problem. In terms of global relevance, a number of lessons have been learned from this exercise: the role of broadly based participation in gaining recognition at the national health policy level; the wide acceptance of an integrated programme model; the relevance of process-related targets to achieve short-term success; and the critical role of having a designated focal point within the managerial approach. PMID:10680245

Precision Control Module For UV Laser 3D Micromachining

NASA Astrophysics Data System (ADS)

Wu, Wen-Hong; Hung, Min-Wei; Chang, Chun-Li

2011-01-01

UV laser has been widely used in various micromachining such as micro-scribing or patterning processing. At present, most of the semiconductors, LEDs, photovoltaic solar panels and touch panels industries need the UV laser processing system. However, most of the UV laser processing applications in the industries utilize two dimensional (2D) plane processing. And there are tremendous business opportunities that can be developed, such as three dimensional (3D) structures of micro-electromechanical (MEMS) sensor or the precision depth control of indium tin oxide (ITO) thin films edge insulation in touch panels. This research aims to develop a UV laser 3D micromachining module that can create the novel applications for industries. By special designed beam expender in optical system, the focal point of UV laser can be adjusted quickly and accurately through the optical path control lens of laser beam expender optical system. Furthermore, the integrated software for galvanometric scanner and focal point adjustment mechanism is developed as well, so as to carry out the precise 3D microstructure machining.

Novel imaging closed loop control strategy for heliostats

NASA Astrophysics Data System (ADS)

Bern, Gregor; Schöttl, Peter; Heimsath, Anna; Nitz, Peter

2017-06-01

Central Receiver Systems use up to thousands of heliostats to concentrate solar radiation. The precise control of heliostat aiming points is crucial not only for efficiency but also for reliable plant operation. Besides the calibration of open loop control systems, closed loop tracking strategies are developed to address a precise and efficient aiming strategy. The need for cost reductions in the heliostat field intensifies the motivation for economic closed loop control systems. This work introduces an approach for a closed loop heliostat tracking strategy using image analysis and signal modulation. The approach aims at the extraction of heliostat focal spot position within the receiver domain by means of a centralized remote vision system decoupled from the rough conditions close to the focal area. Taking an image sequence of the receiver while modulating a signal on different heliostats, their aiming points are retrieved. The work describes the methodology and shows first results from simulations and practical tests performed in small scale, motivating further investigation and deployment.

Optimizing the performance of dual-axis confocal microscopes via Monte-Carlo scattering simulations and diffraction theory.

PubMed

Chen, Ye; Liu, Jonathan T C

2013-06-01

Dual-axis confocal (DAC) microscopy has been found to exhibit superior rejection of out-of-focus and multiply scattered background light compared to conventional single-axis confocal microscopy. DAC microscopes rely on the use of separated illumination and collection beam paths that focus and intersect at a single focal volume (voxel) within tissue. While it is generally recognized that the resolution and contrast of a DAC microscope depends on both the crossing angle of the DAC beams, 2θ, and the focusing numerical aperture of the individual beams, α, a detailed study to investigate these dependencies has not been performed. Contrast and resolution are considered as two main criteria to assess the performance of a point-scanned DAC microscope (DAC-PS) and a line-scanned DAC microscope (DAC-LS) as a function of θ and α. The contrast and resolution of these designs are evaluated by Monte-Carlo scattering simulations and diffraction theory calculations, respectively. These results can be used for guiding the optimal designs of DAC-PS and DAC-LS microscopes.

Electric field measurements across the harang discontinuity. [of the auroral zone

NASA Technical Reports Server (NTRS)

Maynard, N. C.

1974-01-01

The Harang discontinuity, the area separating the positive and negative bay regions in the midnight sector of the auroral zone, is a focal point for changes in behavior of many phenomena. Through this region the electric field rotates through the west from a basically northward field in the positive bay region to a basically southward field in the negative bay region, appearing as a reversal in a single axis measurement; 32 of these reversals have been identified in the OGO-6 data from November and December, 1969. The discontinuity is dynamic in nature, moving southward and steepening its latitudinal profile as magnetic activity is increased. As activity decreases it relaxes poleward and spreads out in latitudinal width. It occurs over several hours of magnetic local time. The boundary in the electric field data is consistent with the reversal of ground magnetic disturbances from a positive to negative bay condition. The discontinuity is present in the electric field data both during substorms and during quiet times and appears to define a pattern on which other effects can occur.

Research on Hartmann test for progressive addition lenses

NASA Astrophysics Data System (ADS)

Qin, Lin-ling; Yu, Jing-chi

2009-05-01

Recently, in the world some growing-up measurements for Progressive addition lenses and relevant equipments have been developed. They are single point measurement, moiré deflectometry, Ronchi test techniques. Hartmann test for Progressive addition lenses is proposed in the article. The measurement principle of Hartmann test for ophthalmic lenses and the power compensation of off-axis rays are introduced. The experimental setup used to test lenses is put forward. For experimental test, a spatial filter is used for selecting a clean Gaussian beam; a collimating lens with focal distance f =300 mm is used to produce collimated beam. The Hartmann plate with a square array of holes separated at 2 mm is selected. The selection of laser and CCD camera is critical to the accuracy of experiment and the image processing algorithm. The spot patterns from CCD are obtained from the experimental tests. The power distribution map for lenses can be obtained by image processing in theory. The results indicate that Hartmann test for Progressive addition lenses is convenient and feasible; also its structure is simple.

The frequency and spectrum of thymus 2-[fluorine-18] fluoro-2-deoxy-D-glucose uptake patterns in hyperthyroidism patients.

PubMed

Chen, Yen-Kung; Yeh, Chia-Lu; Chen, Yen-Ling; Wang, Su-Chen; Cheng, Ru-Hwa; Kao, Pan-Fu

2011-10-01

Thymic hyperplasia is associated with hyperthyroidism. Increased thymus 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) uptake in hyperthyroidism patients has been reported. The aim of this study was to analyze the FDG positron emission tomography (PET) thymus uptake spectrum in patients with active hyperthyroidism with correlation with serum hormones. The prospective study included FDG PET scans from 65 hyperthyroidism patients and 30 subjects with euthyroid status as control group. The intensity of FDG uptake in thyroid and thymus regions was graded subjectively on a five-point scale and semi-quantitatively by measuring standard uptake value (SUV). Correlation coefficient between thymus SUV and serum thyroxine, triiodothyronine, thyrotropin, thyroid peroxidase antibodies (TPO Ab), thyrotropin receptor autoantibody (TR Ab), and thymulin were analyzed. Among 65 hyperthyroidism patients, 30 (46.2%) and 39 (60%) patients showed thyroid and thymus FDG uptake, respectively. The frequency of thymus uptake FDG was high in patients younger than age 40 (28/31, 90.3%). The patterns of the thymic FDG uptake include inverted V or triangular, separated triangular, united nontriangular, unilateral right or left extension, and focal midline. Focal midline FDG uptake was the most common pattern (15/39, 38.5%). None of the control group showed thymus FDG uptake. The correlation coefficient between the FDG uptake SUV levels in thymus and serum hormones, thyrotropin, TPO Ab, TR Ab, and thymulin levels were all low (P > .05). In FDG PET scan, thymus activity was common in hyperthyroidism patients; this should not be misdiagnosed as a malignancy in patients exhibiting weight loss. Copyright © 2011 AUR. Published by Elsevier Inc. All rights reserved.

A Lightweight, Precision-Deployable, Optical Bench for High Energy Astrophysics Missions

NASA Astrophysics Data System (ADS)

Danner, Rolf; Dailey, D.; Lillie, C.

2011-09-01

The small angle of total reflection for X-rays, forcing grazing incidence optics with large collecting areas to long focal lengths, has been a fundamental barrier to the advancement of high-energy astrophysics. Design teams around the world have long recognized that a significant increase in effective area beyond Chandra and XMM-Newton requires either a deployable optical bench or separate X-ray optics and instrument module on formation flying spacecraft. Here, we show that we have in hand the components for a lightweight, precision-deployable optical bench that, through its inherent design features, is the affordable path to the next generation of imaging high-energy astrophysics missions. We present our plans for a full-scale engineering model of a deployable optical bench for Explorer-class missions. We intend to use this test article to raise the technology readiness level (TRL) of the tensegrity truss for a lightweight, precision-deployable optical bench for high-energy astrophysics missions from TRL 3 to TRL 5 through a set of four well-defined technology milestones. The milestones cover the architecture's ability to deploy and control the focal point, characterize the deployed dynamics, determine long-term stability, and verify the stowed load capability. Our plan is based on detailed design and analysis work and the construction of a first prototype by our team. Building on our prior analysis and the high TRL of the architecture components we are ready to move on to the next step. The key elements to do this affordably are two existing, fully characterized, flight-quality, deployable booms. After integrating them into the test article, we will demonstrate that our architecture meets the deployment accuracy, adjustability, and stability requirements. The same test article can be used to further raise the TRL in the future.

Imaging X-Ray Polarimetry Explorer Mission Attitude Determination and Control Concept

NASA Technical Reports Server (NTRS)

Bladt, Jeff; Deininger, William D.; Kalinowski, William C.; Boysen, Mary; Bygott, Kyle; Guy, Larry; Pentz, Christina; Seckar, Chris; Valdez, John; Wedmore, Jeffrey;

Identification of Baribis fault - West Java using second vertical derivative method of gravity

NASA Astrophysics Data System (ADS)

Sari, Endah Puspita; Subakti, Hendri

2015-04-01

Baribis fault is one of West Java fault zones which is an active fault. In modern era, the existence of fault zone can be observed by gravity anomaly. Baribis fault zone has not yet been measured by gravity directly. Based on this reason, satellite data supported this research. Data used on this research are GPS satellite data downloaded from TOPEX. The purpose of this research is to determine the type and strike of Baribis fault. The scope of this research is Baribis fault zone which lies on 6.50o - 7.50o S and 107.50o - 108.80o E. It consists of 5146 points which one point to another is separated by 1 minute meridian. The method used in this research is the Second Vertical Derivative (SVD) of gravity anomaly. The Second Vertical Derivative of gravity anomaly show as the amplitude of gravity anomaly caused by fault structure which appears as residual anomaly. The zero value of residual gravity anomaly indicates that the contact boundary of fault plane. Second Vertical Derivative method of gravity was applied for identifying Baribis fault. The result of this research shows that Baribis fault has a thrust mechanism. It has a lineament strike varies from 107o to 127o. This result agrees with focal mechanism data of earthquakes occurring on this region based on Global CMT catalogue.

Fine Guidance Sensing for Coronagraphic Observatories

NASA Technical Reports Server (NTRS)

Brugarolas, Paul; Alexander, James W.; Trauger, John T.; Moody, Dwight C.

2011-01-01

Three options have been developed for Fine Guidance Sensing (FGS) for coronagraphic observatories using a Fine Guidance Camera within a coronagraphic instrument. Coronagraphic observatories require very fine precision pointing in order to image faint objects at very small distances from a target star. The Fine Guidance Camera measures the direction to the target star. The first option, referred to as Spot, was to collect all of the light reflected from a coronagraph occulter onto a focal plane, producing an Airy-type point spread function (PSF). This would allow almost all of the starlight from the central star to be used for centroiding. The second approach, referred to as Punctured Disk, collects the light that bypasses a central obscuration, producing a PSF with a punctured central disk. The final approach, referred to as Lyot, collects light after passing through the occulter at the Lyot stop. The study includes generation of representative images for each option by the science team, followed by an engineering evaluation of a centroiding or a photometric algorithm for each option. After the alignment of the coronagraph to the fine guidance system, a "nulling" point on the FGS focal point is determined by calibration. This alignment is implemented by a fine alignment mechanism that is part of the fine guidance camera selection mirror. If the star images meet the modeling assumptions, and the star "centroid" can be driven to that nulling point, the contrast for the coronagraph will be maximized.

Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology.

PubMed

Taljanovic, Mihra S; Graham, Anna R; Benjamin, James B; Gmitro, Arthur F; Krupinski, Elizabeth A; Schwartz, Stephanie A; Hunter, Tim B; Resnick, Donald L

2008-05-01

To correlate the amount of bone marrow edema (BME) calculated by magnetic resonance imaging(MRI) with clinical findings, histopathology, and radiographic findings, in patients with advanced hip osteoarthritis(OA). The study was approved by The Institutional Human Subject Protection Committee. Coronal MRI of hips was acquired in 19 patients who underwent hip replacement. A spin echo (SE) sequence with four echoes and separate fast spin echo (FSE) proton density (PD)-weighted SE sequences of fat (F) and water (W) were acquired with water and fat suppression, respectively. T2 and water:fat ratio calculations were made for the outlined regions of interest. The calculated MRI values were correlated with the clinical, radiographic, and histopathologic findings. Analyses of variance were done on the MRI data for W/(W + F) and for T2 values (total and focal values) for the symptomatic and contralateral hips. The values were significantly higher in the study group. Statistically significant correlations were found between pain and total W/(W + F), pain and focal T2 values, and the number of microfractures and calculated BME for the focal W/(W + F) in the proximal femora. Statistically significant correlations were found between the radiographic findings and MRI values for total W/(W + F), focal W/(W + F) and focal T2 and among the radiographic findings, pain, and hip movement. On histopathology, only a small amount of BME was seen in eight proximal femora. The amount of BME in the OA hip, as measured by MRI, correlates with the severity of pain, radiographic findings, and number of microfractures.

The effects of longitudinal chromatic aberration and a shift in the peak of the middle-wavelength sensitive cone fundamental on cone contrast

PubMed Central

Rucker, F. J.; Osorio, D.

2009-01-01

Longitudinal chromatic aberration is a well-known imperfection of visual optics, but the consequences in natural conditions, and for the evolution of receptor spectral sensitivities are less well understood. This paper examines how chromatic aberration affects image quality in the middle-wavelength sensitive (M-) cones, viewing broad-band spectra, over a range of spatial frequencies and focal planes. We also model the effects on M-cone contrast of moving the M-cone fundamental relative to the long- and middle-wavelength (L- and M-cone) fundamentals, while the eye is accommodated at different focal planes or at a focal plane that maximizes luminance contrast. When the focal plane shifts towards longer (650 nm) or shorter wavelengths (420 nm) the effects on M-cone contrast are large: longitudinal chromatic aberration causes total loss of M-cone contrast above 10 to 20 c/d. In comparison, the shift of the M-cone fundamental causes smaller effects on M-cone contrast. At 10 c/d a shift in the peak of the M-cone spectrum from 560 nm to 460 nm decreases M-cone contrast by 30%, while a 10 nm blue-shift causes only a minor loss of contrast. However, a noticeable loss of contrast may be seen if the eye is focused at focal planes other than that which maximizes luminance contrast. The presence of separate long- and middle-wavelength sensitive cones therefore has a small, but not insignificant cost to the retinal image via longitudinal chromatic aberration. This aberration may therefore be a factor limiting evolution of visual pigments and trichromatic color vision. PMID:18639571

Wavelet Imaging on Multiple Scales (WIMS) reveals focal adhesion distributions, dynamics and coupling between actomyosin bundle stability

PubMed Central

Toplak, Tim; Palmieri, Benoit; Juanes-García, Alba; Vicente-Manzanares, Miguel; Grant, Martin; Wiseman, Paul W.

2017-01-01

We introduce and use Wavelet Imaging on Multiple Scales (WIMS) as an improvement to fluorescence correlation spectroscopy to measure physical processes and features that occur across multiple length scales. In this study, wavelet transforms of cell images are used to characterize molecular dynamics at the cellular and subcellular levels (i.e. focal adhesions). We show the usefulness of the technique by applying WIMS to an image time series of a migrating osteosarcoma cell expressing fluorescently labelled adhesion proteins, which allows us to characterize different components of the cell ranging from optical resolution scale through to focal adhesion and whole cell size scales. Using WIMS we measured focal adhesion numbers, orientation and cell boundary velocities for retraction and protrusion. We also determine the internal dynamics of individual focal adhesions undergoing assembly, disassembly or elongation. Thus confirming as previously shown, WIMS reveals that the number of adhesions and the area of the protruding region of the cell are strongly correlated, establishing a correlation between protrusion size and adhesion dynamics. We also apply this technique to characterize the behavior of adhesions, actin and myosin in Chinese hamster ovary cells expressing a mutant form of myosin IIB (1935D) that displays decreased filament stability and impairs front-back cell polarity. We find separate populations of actin and myosin at each adhesion pole for both the mutant and wild type form. However, we find these populations move rapidly inwards toward one another in the mutant case in contrast to the cells that express wild type myosin IIB where those populations remain stationary. Results obtained with these two systems demonstrate how WIMS has the potential to reveal novel correlations between chosen parameters that belong to different scales. PMID:29049414

Differential focal and nonfocal prospective memory accuracy in a demographically diverse group of nondemented community-dwelling older adults.

PubMed

Chi, Susan Y; Rabin, Laura A; Aronov, Avner; Fogel, Joshua; Kapoor, Ashu; Wang, Cuiling

2014-11-01

Although prospective memory (PM) is compromised in mild cognitive impairment (MCI), it is unclear which specific cognitive processes underlie these PM difficulties. We investigated older adults' performance on a computerized event-based focal versus nonfocal PM task that made varying demands on the amount of attentional control required to support intention retrieval. Participants were nondemented individuals (mean age=81.8 years; female=66.1%) enrolled in a community-based longitudinal study, including those with amnestic MCI (aMCI), nonamnestic MCI (naMCI), subjective cognitive decline (SCD), and healthy controls (HC). Participants included in the primary analysis (n=189) completed the PM task and recalled and/or recognized both focal and nonfocal PM cues presented in the task. Participants and their informants also completed a questionnaire assessing everyday PM failures. Relative to HC, those with aMCI and naMCI were significantly impaired in focal PM accuracy (p<.05). In a follow-up analysis that included 13 additional participants who successfully recalled and/or recognized at least one of the two PM cues, the naMCI group showed deficits in nonfocal PM accuracy (p<.05). There was a significant negative correlation between informant reports of PM difficulties and nonfocal PM accuracy (p<.01). PM failures in aMCI may be primarily related to impairment of spontaneous retrieval processes associated with the medial temporal lobe system, while PM failures in naMCI potentially indicate additional deficits in executive control functions and prefrontal systems. The observed focal versus nonfocal PM performance profiles in aMCI and naMCI may constitute specific behavioral markers of PM decline that result from compromise of separate neurocognitive systems.

Control of treatment size in cavitation-enhanced high-intensity focused ultrasound using radio-frequency echo signals

NASA Astrophysics Data System (ADS)

Tomiyasu, Kentaro; Takagi, Ryo; Iwasaki, Ryosuke; Yoshizawa, Shin; Umemura, Shin-ichiro

2017-07-01

In high-intensity focused ultrasound (HIFU) treatment, controlling the ultrasound dose at each focal target spot is important because it is a problem that the length of the coagulated region in front of the focal point deviates owing to the differences in absorption in each focal target spot and attenuation in the intervening tissues. In this study, the detected changes in the power spectra of HIFU echoes were used by controlling the HIFU duration in the “trigger HIFU” sequence with the aim to increase coagulation size through the enhancement of the ultrasonic heating by the cavitation induced by the preceding extremely high intensity short “trigger” pulse. The result shows that this method can be used to detect boiling bubbles and the following generated cavitation bubbles at their early stage. By automatically stopping HIFU exposure immediately after detecting the bubbles, overheating was prevented and the deviation of the length of the coagulated region was reduced.

Enchanced interference cancellation and telemetry reception in multipath environments with a single paraboic dish antenna using a focal plane array

NASA Technical Reports Server (NTRS)

Vilnrotter, Victor A. (Inventor); Mukai, Ryan (Inventor)

2011-01-01

An Advanced Focal Plane Array ("AFPA") for parabolic dish antennas that exploits spatial diversity to achieve better channel equalization performance in the presence of multipath (better than temporal equalization alone), and which is capable of receiving from two or more sources within a field-of-view in the presence of multipath. The AFPA uses a focal plane array of receiving elements plus a spatio-temporal filter that keeps information on the adaptive FIR filter weights, relative amplitudes and phases of the incoming signals, and which employs an Interference Cancelling Constant Modulus Algorithm (IC-CMA) that resolves multiple telemetry streams simultaneously from the respective aero-nautical platforms. This data is sent to an angle estimator to calculate the target's angular position, and then on to Kalman filters FOR smoothing and time series prediction. The resulting velocity and acceleration estimates from the time series data are sent to an antenna control unit (ACU) to be used for pointing control.

Big capabilities in small packages: hyperspectral imaging from a compact platform

NASA Astrophysics Data System (ADS)

Beasley, Matthew; Goldberg, Hannah; Voorhees, Christopher; Illsley, Peter

2016-09-01

We present the Compact Holographic Aberration-corrected Platform (CHAP) instrument, designed and developed at Planetary Resources Development Corporation. By combining a dispersive element with the secondary of a telescope, we are able to produce a relatively long focal length with moderate dispersion at the focal plane. This design enables us to build a capable hyperspectral imaging instrument within the size constraints of the Cubesat form-factor. The advantages of our design revolves around its simplicity: there are only two optical elements, producing both a white light and diffracted image. With the use of a replicated grating, we can produce a long focal length hyperspectral imager at a price point far below other spaceflight instruments. The design is scalable for larger platforms and since it has no transmitting optics and only two reflective surfaces could be designed to function at any desired wavelength. Our system will be capable of spectral imaging across the 400 to 900 nm spectral range for use in small body surveys.

Nonlinear Focal Modulation Microscopy.

PubMed

Zhao, Guangyuan; Zheng, Cheng; Kuang, Cuifang; Zhou, Renjie; Kabir, Mohammad M; Toussaint, Kimani C; Wang, Wensheng; Xu, Liang; Li, Haifeng; Xiu, Peng; Liu, Xu

2018-05-11

We demonstrate nonlinear focal modulation microscopy (NFOMM) to achieve superresolution imaging. Traditional approaches to superresolution that utilize point scanning often rely on spatially reducing the size of the emission pattern by directly narrowing (e.g., through minimizing the detection pinhole in Airyscan, Zeiss) or indirectly peeling its outer profiles [e.g., through depleting the outer emission region in stimulated emission depletion (STED) microscopy]. We show that an alternative conceptualization that focuses on maximizing the optical system's frequency shifting ability offers advantages in further improving resolution while reducing system complexity. In NFOMM, a spatial light modulator and a suitably intense laser illumination are used to implement nonlinear focal-field modulation to achieve a transverse spatial resolution of ∼60  nm (∼λ/10). We show that NFOMM is comparable with STED microscopy and suitable for fundamental biology studies, as evidenced in imaging nuclear pore complexes, tubulin and vimentin in Vero cells. Since NFOMM is readily implemented as an add-on module to a laser-scanning microscope, we anticipate wide utility of this new imaging technique.

Effect of the focal plane position on CO2 laser beam cutting of injection molded polycarbonate sheets

NASA Astrophysics Data System (ADS)

Moradi, Mahmoud; Mehrabi, Omid; Azdast, Taher; Benyounis, Khaled Y.

2016-11-01

In the present research, the effect of laser beam focal plane position (FPP) on the kerf quality of the polycarbonate laser cutting is investigated. Low power CO2 laser is used as the heat source of the cutting runs. In the experiments, FPP is varied from 0 to -4mm while other processing parameters (i.e. laser power, cutting speed and gas pressure) are considered constant. Upper and lower kerf width, kerf taper, upper heat affected zone and surface roughness of the kerf wall are also considered as the responses. Observations signified that reducing the position of the laser beam focal point from zero to - 3mm reduces the upper and lower kerf width. However reducing FPP below -3mm leads to an increase in the kerf width. Results also reveals that upper heat affected zone value reduces by reduction in FPP. Moreover the best kerf wall surface roughness occurred at FPP= -3mm.

Efficacy and tolerability of oral lacosamide as adjunctive therapy in pediatric patients with pharmacoresistant focal epilepsy.

PubMed

Gavatha, M; Ioannou, I; Papavasiliou, A S

2011-04-01

The results of adjunctive lacosamide treatment in 18 pediatric patients with pharmacoresistant focal epilepsy are reported. All had severe forms of focal epilepsy with or without secondary generalization and were concurrently receiving one to three other antiepileptic drugs. Lacosamide was administered orally, and final dose, after slow titration, ranged between 1.7 and 10 mg/kg. Mean treatment duration was 8 months (range=3 weeks-17 months). Treatment efficacy was assessed at two time points with a 1-year interval. The reported greater than 50% reduction in seizure frequency was 36% in the initial short-term and 20% in the following long-term assessment. Side effects, mostly somnolence and irritability, were reported by 39% of patients in both evaluations. Our data suggest that lacosamide treatment in pediatric patients is safe at doses up to 10 mg/kg/day without any major side effects, but studies in larger series are needed to validate and extend these findings. Copyright © 2011 Elsevier Inc. All rights reserved.

Nonlinear Focal Modulation Microscopy

NASA Astrophysics Data System (ADS)

Zhao, Guangyuan; Zheng, Cheng; Kuang, Cuifang; Zhou, Renjie; Kabir, Mohammad M.; Toussaint, Kimani C.; Wang, Wensheng; Xu, Liang; Li, Haifeng; Xiu, Peng; Liu, Xu

2018-05-01

We demonstrate nonlinear focal modulation microscopy (NFOMM) to achieve superresolution imaging. Traditional approaches to superresolution that utilize point scanning often rely on spatially reducing the size of the emission pattern by directly narrowing (e.g., through minimizing the detection pinhole in Airyscan, Zeiss) or indirectly peeling its outer profiles [e.g., through depleting the outer emission region in stimulated emission depletion (STED) microscopy]. We show that an alternative conceptualization that focuses on maximizing the optical system's frequency shifting ability offers advantages in further improving resolution while reducing system complexity. In NFOMM, a spatial light modulator and a suitably intense laser illumination are used to implement nonlinear focal-field modulation to achieve a transverse spatial resolution of ˜60 nm (˜λ /10 ). We show that NFOMM is comparable with STED microscopy and suitable for fundamental biology studies, as evidenced in imaging nuclear pore complexes, tubulin and vimentin in Vero cells. Since NFOMM is readily implemented as an add-on module to a laser-scanning microscope, we anticipate wide utility of this new imaging technique.

Ultrasound elastographic techniques in focal liver lesions

PubMed Central

Conti, Clara Benedetta; Cavalcoli, Federica; Fraquelli, Mirella; Conte, Dario; Massironi, Sara

2016-01-01

Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, transient elastography and acoustic radiation force imaging methods, which include point shear wave and shear wave imaging elastography. The application of these methods in clinical practice aims at estimating the mechanical tissues properties. One of the main settings for the application of these tools has been liver stiffness assessment in chronic liver disease, which has been studied mainly using transient elastography. Another field of application for these techniques is the assessment of focal lesions, detected by ultrasound in organs such as pancreas, prostate, breast, thyroid, lymph nodes. Considering the frequency and importance of the detection of focal liver lesions through routine ultrasound, some studies have also aimed to assess the role that elestography can play in studying the stiffness of different types of liver lesions, in order to predict their nature and thus offer valuable non-invasive methods for the diagnosis of liver masses. PMID:26973405

Ultrasound elastographic techniques in focal liver lesions.

PubMed

Conti, Clara Benedetta; Cavalcoli, Federica; Fraquelli, Mirella; Conte, Dario; Massironi, Sara

2016-03-07

Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, transient elastography and acoustic radiation force imaging methods, which include point shear wave and shear wave imaging elastography. The application of these methods in clinical practice aims at estimating the mechanical tissues properties. One of the main settings for the application of these tools has been liver stiffness assessment in chronic liver disease, which has been studied mainly using transient elastography. Another field of application for these techniques is the assessment of focal lesions, detected by ultrasound in organs such as pancreas, prostate, breast, thyroid, lymph nodes. Considering the frequency and importance of the detection of focal liver lesions through routine ultrasound, some studies have also aimed to assess the role that elestography can play in studying the stiffness of different types of liver lesions, in order to predict their nature and thus offer valuable non-invasive methods for the diagnosis of liver masses.

Mispronunciation Detection for Language Learning and Speech Recognition Adaptation

ERIC Educational Resources Information Center

Ge, Zhenhao

2013-01-01

The areas of "mispronunciation detection" (or "accent detection" more specifically) within the speech recognition community are receiving increased attention now. Two application areas, namely language learning and speech recognition adaptation, are largely driving this research interest and are the focal points of this work.…

Women's Handwork: Stories of Similarity and Diversity.

ERIC Educational Resources Information Center

Kellman, Julia

1996-01-01

Characterizes women's handwork (needlepoint, beadwork, embroidery, crocheting) as a valid means of artistic expression and an integral part of women's culture. Discusses the varieties of handwork and their relationships within local cultures. Recommends using these objects as focal points for studying art, local history, or social studies. (MJP)

Compact range for variable-zone measurements

DOEpatents

Burnside, W.D.; Rudduck, R.C.; Yu, J.S.

1987-02-27

A compact range for testing antennas or radar targets includes a source for directing energy along a feedline toward a parabolic reflector. The reflected wave is a spherical wave with a radius dependent on the distance of the source from the focal point of the reflector. 2 figs.

7 CFR 2.72 - Chairman, World Agricultural Outlook Board.

Code of Federal Regulations, 2014 CFR

2014-01-01

... climate. (i) Advise the Secretary on climate and weather activities, and coordinate the development of policy options on weather and climate. (ii) Coordinate all weather and climate information and monitoring activities within the Department and provide a focal point in the Department for weather and climate...

7 CFR 2.72 - Chairman, World Agricultural Outlook Board.

Code of Federal Regulations, 2011 CFR

2011-01-01

... climate. (i) Advise the Secretary on climate and weather activities, and coordinate the development of policy options on weather and climate. (ii) Coordinate all weather and climate information and monitoring activities within the Department and provide a focal point in the Department for weather and climate...

7 CFR 2.72 - Chairman, World Agricultural Outlook Board.

Code of Federal Regulations, 2012 CFR

2012-01-01

... climate. (i) Advise the Secretary on climate and weather activities, and coordinate the development of policy options on weather and climate. (ii) Coordinate all weather and climate information and monitoring activities within the Department and provide a focal point in the Department for weather and climate...

7 CFR 2.72 - Chairman, World Agricultural Outlook Board.

Code of Federal Regulations, 2013 CFR

2013-01-01

... climate. (i) Advise the Secretary on climate and weather activities, and coordinate the development of policy options on weather and climate. (ii) Coordinate all weather and climate information and monitoring activities within the Department and provide a focal point in the Department for weather and climate...

Ethics of the Health Educator as Behavior Change Agent in Gerontological Health.

ERIC Educational Resources Information Center

Neutens, James J.; Jackson, Michael L.

1985-01-01

As health education becomes a focal point in the health care system, more attention will be given to the professional practice of health educators. Understanding ethical theory and other value judgments will be an important aspect of the health education profession. (DF)

The Dispositions Improvement Process

ERIC Educational Resources Information Center

Brewer, Robin D.; Lindquist, Cynthia; Altemueller, Lisa

2011-01-01

Globally, teacher dispositions along with knowledge and skills continue to be the focal point of teacher education programs. Teachers influence children's development and therefore dispositions are a universal concern. For the past 20 years in the United States, teacher education programs have assessed dispositions. We, however, must now also use…

Standardization in Performance Assessment of Telemetry Tracking Systems

DTIC Science & Technology

2013-09-01

for a defense system against ballistic missiles ( Kaplan , 2008). Back then the threat was realized by Germany’s V-2 rocket, the world’s first...Kennedy of Massachusetts ( Kaplan , 2008). “It is the policy of the United States to deploy as soon as is technologically possible an effective... P2 , and P3. The parabolic dish then reflects all this energy onto the focal point, point F. The feed of the antenna, which encloses or houses the

The Engineer Model Improvement Program Plan

DTIC Science & Technology

1988-08-01

evaluations of engineer doctrine placed it in a unique position to be a focal point for USACE modeling support. To this end, on 3 December of 1986 the CC...community in a 27 February 1980 memorandum in which the Army Chief of Staff urged the Chief of Engineers "... to relook the manner in which engineers...battlefield is controlled through a system of user-established Movement-Control- Points (MCPs). An MCP is described by X-Y-Z coordinates which define a

Estimation of the laser cutting operating cost by support vector regression methodology

NASA Astrophysics Data System (ADS)

Jović, Srđan; Radović, Aleksandar; Šarkoćević, Živče; Petković, Dalibor; Alizamir, Meysam

2016-09-01

Laser cutting is a popular manufacturing process utilized to cut various types of materials economically. The operating cost is affected by laser power, cutting speed, assist gas pressure, nozzle diameter and focus point position as well as the workpiece material. In this article, the process factors investigated were: laser power, cutting speed, air pressure and focal point position. The aim of this work is to relate the operating cost to the process parameters mentioned above. CO2 laser cutting of stainless steel of medical grade AISI316L has been investigated. The main goal was to analyze the operating cost through the laser power, cutting speed, air pressure, focal point position and material thickness. Since the laser operating cost is a complex, non-linear task, soft computing optimization algorithms can be used. Intelligent soft computing scheme support vector regression (SVR) was implemented. The performance of the proposed estimator was confirmed with the simulation results. The SVR results are then compared with artificial neural network and genetic programing. According to the results, a greater improvement in estimation accuracy can be achieved through the SVR compared to other soft computing methodologies. The new optimization methods benefit from the soft computing capabilities of global optimization and multiobjective optimization rather than choosing a starting point by trial and error and combining multiple criteria into a single criterion.

Dynamic Load Predictions for Launchers Using Extra-Large Eddy Simulations X-Les

NASA Astrophysics Data System (ADS)

Maseland, J. E. J.; Soemarwoto, B. I.; Kok, J. C.

2005-02-01

Flow-induced unsteady loads can have a strong impact on performance and flight characteristics of aerospace vehicles and therefore play a crucial role in their design and operation. Complementary to costly flight tests and delicate wind-tunnel experiments, unsteady loads can be calculated using time-accurate Computational Fluid Dynamics. A capability to accurately predict the dynamic loads on aerospace structures at flight Reynolds numbers can be of great value for the design and analysis of aerospace vehicles. Advanced space launchers are subject to dynamic loads in the base region during the ascent to space. In particular the engine and nozzle experience aerodynamic pressure fluctuations resulting from massive flow separations. Understanding these phenomena is essential for performance enhancements for future launchers which operate a larger nozzle. A new hybrid RANS-LES turbulence modelling approach termed eXtra-Large Eddy Simulations (X-LES) holds the promise to capture the flow structures associated with massive separations and enables the prediction of the broad-band spectrum of dynamic loads. This type of method has become a focal point, reducing the cost of full LES, driven by the demand for their applicability in an industrial environment. The industrial feasibility of X-LES simulations is demonstrated by computing the unsteady aerodynamic loads on the main-engine nozzle of a generic space launcher configuration. The potential to calculate the dynamic loads is qualitatively assessed for transonic flow conditions in a comparison to wind-tunnel experiments. In terms of turn-around-times, X-LES computations are already feasible within the time-frames of the development process to support the structural design. Key words: massive separated flows; buffet loads; nozzle vibrations; space launchers; time-accurate CFD; composite RANS-LES formulation.

Modeling of Pixelated Detector in SPECT Pinhole Reconstruction.

PubMed

Feng, Bing; Zeng, Gengsheng L

2014-04-10

A challenge for the pixelated detector is that the detector response of a gamma-ray photon varies with the incident angle and the incident location within a crystal. The normalization map obtained by measuring the flood of a point-source at a large distance can lead to artifacts in reconstructed images. In this work, we investigated a method of generating normalization maps by ray-tracing through the pixelated detector based on the imaging geometry and the photo-peak energy for the specific isotope. The normalization is defined for each pinhole as the normalized detector response for a point-source placed at the focal point of the pinhole. Ray-tracing is used to generate the ideal flood image for a point-source. Each crystal pitch area on the back of the detector is divided into 60 × 60 sub-pixels. Lines are obtained by connecting between a point-source and the centers of sub-pixels inside each crystal pitch area. For each line ray-tracing starts from the entrance point at the detector face and ends at the center of a sub-pixel on the back of the detector. Only the attenuation by NaI(Tl) crystals along each ray is assumed to contribute directly to the flood image. The attenuation by the silica (SiO 2 ) reflector is also included in the ray-tracing. To calculate the normalization for a pinhole, we need to calculate the ideal flood for a point-source at 360 mm distance (where the point-source was placed for the regular flood measurement) and the ideal flood image for the point-source at the pinhole focal point, together with the flood measurement at 360 mm distance. The normalizations are incorporated in the iterative OSEM reconstruction as a component of the projection matrix. Applications to single-pinhole and multi-pinhole imaging showed that this method greatly reduced the reconstruction artifacts.

Total reaction cross sections and neutron-removal cross sections of neutron-rich light nuclei measured by the COMBAS fragment-separator

NASA Astrophysics Data System (ADS)

Hue, B. M.; Isataev, T.; Erdemchimeg, B.; Artukh, A. G.; Aznabaev, D.; Davaa, S.; Klygin, S. A.; Kononenko, G. A.; Khuukhenkhuu, G.; Kuterbekov, K.; Lukyanov, S. M.; Mikhailova, T. I.; Maslov, V. A.; Mendibaev, K.; Sereda, Yu M.; Penionzhkevich, Yu E.; Vorontsov, A. N.

2017-12-01

Preliminary results of measurements of the total reaction cross sections σR and neutron removal cross section σ-xn for weakly bound 6He, 8Li, 9Be and 10Be nuclei at energy range (20-35) A MeV with 28Si target is presented. The secondary beams of light nuclei were produced by bombardment of the 22Ne (35 A MeV) primary beam on Be target and separated by COMBAS fragment-separator. In dispersive focal plane a horizontal slit defined the momentum acceptance as 1% and a wedge degrader of 200 μm Al was installed. The Bρ of the second section of the fragment-separator was adjusted for measurements in energy range (20-35) A MeV. Two-neutron removal cross sections for 6He and 10Be and one -neutron removal cross sections 8Li and 9Be were measured.

Shape analysis of cylindrical micromirrors for angular focusing

NASA Astrophysics Data System (ADS)

Hou, Max Ti-Kuang; Hong, Pei-Yuan; Chen, Rongshun

2001-11-01

In this paper, we analyze the shape of the cylindrical micromirror, which directly defines the profile of the reflecting surface, and is very important for the function on focusing. A cylindrical micromirror can converge incident rays to a real focal line after reflection, namely angular focusing. Therefore, under specific design two cylindrical micromirrors, the primary and secondary, can converge incident rays into a real focal point after twice reflection. The curved shape of micromirror, formed due to the stress-induced bending of the bilayer microstructure upon release, has been theoretically analyzed and numerically simulated. The results show that the reflecting surface, especially at boundaries, is not perfectly cylindrical, while adding longitudinal frames can make some improvement.

OAJ 2.6m survey telescope: optical alignment and on-sky evaluation of IQ performances

NASA Astrophysics Data System (ADS)

Lousberg, Gregory P.; Bastin, Christian; Moreau, Vincent; Pirnay, Olivier; Flebus, Carlo; Chueca, Sergio; Iñiguez, César; Ederoclite, Alessandro; Ramió, Héctor V.; Cenarro, A. Javier

2016-08-01

AMOS has recently completed the alignment campaign of the 2.6m telescope for the Observatorio Astrofisico de Javalambre (OAJ). AMOS developed an innovative alignment technique for wide field-of-view telescopes that has been successfully implemented on the OAJ 2.6m telescope with the active support of the team of CEFCA (Centro de Estudios de Física del Cosmos de Aragón). The alignment relies on two fundamental techniques: (1) the wavefront-curvature sensing (WCS) for the evaluation of the telescope aberrations at arbitrary locations in the focal plane, and (2) the comafree point method for the adjustment of the position of the secondary mirror (M2) and of the focal plane (FP). The alignment campaign unfolds in three steps: (a) analysis of the repeatability of the WCS measurements, (b) assessment of the sensitivity of telescope wavefront error to M2 and FP position adjustments, and (c) optical alignment of the telescope. At the end of the campaign, seeing-limited performances are demonstrated in the complete focal plane. With the help of CEFCA team, the image quality of the telescope are investigated with a lucky-imaging method. Image sizes of less than 0.3 arcsec FWHM are obtained, and this excellent image quality is observed over the complete focal plane.

Large incidence angle and defocus influence cat's eye retro-reflector

NASA Astrophysics Data System (ADS)

Zhang, Lai-xian; Sun, Hua-yan; Zhao, Yan-zhong; Yang, Ji-guang; Zheng, Yong-hui

2014-11-01

Cat's eye lens make the laser beam retro-reflected exactly to the opposite direction of the incidence beam, called cat's eye effect, which makes rapid acquiring, tracking and pointing of free space optical communication possible. Study the influence of cat's eye effect to cat's eye retro-reflector at large incidence angle is useful. This paper analyzed the process of how the incidence angle and focal shit affect effective receiving area, retro-reflected beam divergence angle, central deviation of cat's eye retro-reflector at large incidence angle and cat's eye effect factor using geometrical optics method, and presented the analytic expressions. Finally, numerical simulation was done to prove the correction of the study. The result shows that the efficiency receiving area of cat's eye retro-reflector is mainly affected by incidence angle when the focal shift is positive, and it decreases rapidly when the incidence angle increases; the retro-reflected beam divergence and central deviation is mainly affected by focal shift, and within the effective receiving area, the central deviation is smaller than beam divergence in most time, which means the incidence beam can be received and retro-reflected to the other terminal in most time. The cat's eye effect factor gain is affected by both incidence angle and focal shift.

Food for Thought.

ERIC Educational Resources Information Center

Harriman, Cliff; And Others

This document describes "Food for Thought," a multidisciplinary project for grades 5 through 8, using nutrition as a focal point. The program focuses on the popular topic of food to make the study of different cultures and historic periods more relevant. In the program students research the diets and prepare the meals of cultures they…

78 FR 30307 - Statement of Organization, Functions, and Delegations of Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

..., 2013. Sherri A. Berger, Chief Operating Officer, Centers for Disease Control and Prevention. [FR Doc... financial management; (19) serves as focal point for emergency operations and deployment; (20) manages and... priorities and objectives and reassesses the role of NCHHSTP field staff assignees to state and local health...

Application of the canonical operator to the description of self-focusing soliton-like solutions of the Kadomtsev-Petviashvili equation

NASA Astrophysics Data System (ADS)

Maslov, V. P.; Shafarevich, A. I.

2011-12-01

A description for the asymptotic soliton-like solution of the Kadomtsev-Petviashvili I equation (KPI equation) in terms of the canonical operator is suggested. This solution can smoothly be continued to the vicinity of the focal point.

A Discovery Chemistry Experiment on Buffers

ERIC Educational Resources Information Center

Kulevich, Suzanne E.; Herrick, Richard S.; Mills, Kenneth V.

2014-01-01

The Holy Cross Chemistry Department has designed and implemented an experiment on buffers as part of our Discovery Chemistry curriculum. The pedagogical philosophy of Discovery Chemistry is to make the laboratory the focal point of learning for students in their first two years of undergraduate instruction. We first pose questions in prelaboratory…

Leadership Excellence through Advancement and Determination Program: A Qualitative Case Study

ERIC Educational Resources Information Center

Perrell, Wendy M.

2012-01-01

Alaska Native leadership development programs are often used to prepare participants and to enhance their leadership potential. The cultural appropriateness of developing Alaska Native leaders through the Western-structured LEAD program was the focal point of this study. Understanding how the LEAD participants adapted to Native and Western…

Solo and Distributed Leadership: Definitions and Dilemmas

ERIC Educational Resources Information Center

Crawford, Megan

2012-01-01

This article discusses solo and distributed leadership. Using the anniversary of "Educational Management Administration & Leadership" as a focal point, it looks back over the last 40 years of "EMAL", using this to frame a wider discussion of the relationship between solo and distributed leadership approaches. It acknowledges other approaches to…

Scattering and Propagation in Random Media

DTIC Science & Technology

1988-01-01

courts porno C~r) module Au champ darns Is pupille A,Ca)4 amplitude complex* Au chomp danms 1. plan focal OMf fouction As tranefert longue point do...instantenie N nosbre minimum d~imagem A utilimer doen les algorithmasm I noabre As taveluros prisontos darns V image courts porno N) noabre do moum

The Impact of Institutional Grant Aid on College Choice

ERIC Educational Resources Information Center

Hurwitz, Michael Drew

2011-01-01

The influence of institutional grant aid on the enrollment behavior of college students has been the focal point of several empirical studies during the past decade. Yet, the extent to which this multibillion dollar per year grant-allocation process influences the matriculation choices of students deciding between multiple institutions remains…

Ghosts of the Past: Character Journals from the Titanic.

ERIC Educational Resources Information Center

LaBonty, Jan

1998-01-01

Describes an assignment used in a reading/language arts course for elementary education majors that uses Robert Ballard's factual book "Exploring the Titanic" as a focal point for a character journal assignment. Notes students' enthusiastic responses to this assignment. Describes how this assignment could be adapted to a middle- or…

Language Choice in Multilingual Encounters in Transnational Workplaces

ERIC Educational Resources Information Center

Kingsley, Leilarna

2013-01-01

This paper is based on research conducted in banks in the international banking centre of Luxembourg. Operating in the globalised context of international banking and multilingual Luxembourg, financial institutions are an ideal focal point for investigating policy and practices in complex multilingual and transnational work spaces. Two theoretical…

48 CFR 304.7001 - Numbering acquisitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracting office identification codes currently in use is contained in the DCIS Users' Manual, available at... than one code may apply in a specific situation, or for additional codes, refer to the DCIS Users' Manual or consult with the cognizant DCIS coordinator/focal point for guidance on which code governs...

Afterschool Essentials: Research and Polling

ERIC Educational Resources Information Center

Afterschool Alliance, 2013

2013-01-01

This 2-page resource summarizes statistical findings highlighting the need and demand for more afterschool programs for children and youth. Focal points include: (1) The Afterschool Hours in America; (2) Afterschool Offers a Range of Benefits to Youth and their Families; (3) Afterschool Supports Student Success; (4) Afterschool Programs Are Seen…

Spatial Distribution and Morphology of Sediments in Texas Southern High Plains Playa Wetlands

USDA-ARS?s Scientific Manuscript database

Playas are depressional geomorphic features on the U.S. High Plains and about 20,000 Southern High Plains playa wetlands serve as runoff catchment basins, which are thought to be focal points of Ogallala aquifer recharge. Sediments in playas can alter biodiversity services, impede aquifer recharge,...

Origins of Coordinate Searching.

ERIC Educational Resources Information Center

Kilgour, Frederick G.

1997-01-01

Reviews the origins of post-coordinate searching and emphasizes that the focal point should be on the searcher, not on the item being indexed. Highlights include the history of the term information retrieval; edge notched punch cards; the "peek-a-boo" system; the Uniterm system; and using computers to search for information. (LRW)

Inviting other professions to help reduce wildfire property losses

Treesearch

A. Fege; J. Absher

2007-01-01

Preventing structure loss has become a major focal point of wildland firefighting. Most days it feels like wildland fire professionals and land managers are become more and more responsible for reducing property losses in the wildland/urban interface (WUI).What if this impression-and reality-could change?

Virtual Schools in the U.S. 2017

ERIC Educational Resources Information Center

Molnar, Alex; Miron, Gary; Gulosino, Charisse; Shank, Christopher; Davidson, Caryn; Barbour, Michael; Huerta, Luis; Shafter, Sheryl Rankin; Rice, Jennifer King; Nitkin, David

2017-01-01

In the five years since the first National Education Policy Center (NEPC) "Annual Report on Virtual Education" was released in 2013, virtual education has continued to be a focal point for policymakers. Proponents argue that virtual education can expand student choices and improve the efficiency of public education. In particular,…

Identification of methyl farnesoate from the hemolymph of insects

USDA-ARS?s Scientific Manuscript database

Juvenile hormones (JH) have been a focal point of study in insect endocrinology for more than 80 years and are implicated in regulation of more physiological and behavioral functions than any other insect hormone. Indeed, evidence has suggested that JHs are the only sesquiterpene hormone products s...

Blind Students Learn Food Skills

ERIC Educational Resources Information Center

Pass, Gisela; Uhlinger, Susan J.

1970-01-01

The problems of cooking and working in the kitchen were the focal point of a series of six lessons given by the Hampden County, Massachusetts, Extension Service for 16 blind men and women. The basic purpose of the course was to help them develop self-reliance in relation to meal preparation. (Author/MF)

Testing wetland axioms at a watershed scale: Case studies of the aggregate hydrologic effects of non-adjacent wetlands

EPA Science Inventory

Wetlands not adjacent to streams (i.e. “non-adjacent wetlands”) are hypothesized to affect downgradient hydrology in a number of ways. Non-adjacent wetlands may, for example, attenuate peak flows, serve as focal points for groundwater recharge, and decrease streamflow...

10 CFR 603.1115 - Single audits.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Single audits. 603.1115 Section 603.1115 Energy DEPARTMENT... Administration § 603.1115 Single audits. For audits of for-profit participant's systems, under §§ 603.640 through 603.660, the contracting officer is the focal point for ensuring that participants submit audit...

Sharing a Vision.

ERIC Educational Resources Information Center

Cox, Susan M.

1999-01-01

Explains how one New Orleans (LA) school is making a positive difference in a low-income community by serving as the community's focal point and providing the community access to a public library, computers, and a learning center. Highlights the development of the Greater New Orleans Education Foundation and its assessment process, designed to…

Immersive Educational Technology: Changing Families and Learning.

ERIC Educational Resources Information Center

Ehrich, Roger W.; McCreary, Faith

Since the popularization of networked computing that began in 1993, many excited educators have employed networked computers to improve motivation and learning in the classroom. Computers have also become a focal point for the improvement of instruction through the introduction of teaching methods that better support constructivist learning. While…

Standards Writers Wade into Curriculum

ERIC Educational Resources Information Center

Gewertz, Catherine

2011-01-01

New guidelines on crafting curriculum materials for the common standards in English/language arts are reigniting debate about how to ensure a marketplace of good instructional materials for the new standards without crossing the line into telling teachers how to teach. The focal point of the conversations is a set of "publishers' criteria" issued…

A Vital Equation: School + Museum + Community = Learning Through the Arts

ERIC Educational Resources Information Center

Davis, Cecille

1976-01-01

Article described Project "Turn-On," which took place at the Cloisters in New York City, designed to introduce children and teachers in District 6 in upper Manhattan to the beautiful and unusual "neighborhood" museum that became the focal point for active learning in many areas. (Author/RK)

18 CFR 740.1 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Purpose and scope. 740.1 Section 740.1 Conservation of Power and Water Resources WATER RESOURCES COUNCIL STATE WATER... focal point for the management of water and related land resources, this part establishes guidelines for...

18 CFR 740.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Purpose and scope. 740.1 Section 740.1 Conservation of Power and Water Resources WATER RESOURCES COUNCIL STATE WATER... focal point for the management of water and related land resources, this part establishes guidelines for...

18 CFR 740.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Purpose and scope. 740.1 Section 740.1 Conservation of Power and Water Resources WATER RESOURCES COUNCIL STATE WATER... focal point for the management of water and related land resources, this part establishes guidelines for...

Organizational Politics in Schools: Micro, Macro, and Logics of Action.

ERIC Educational Resources Information Center

Bacharach, Samuel B.; Mundell, Bryan L.

1993-01-01

Develops a framework for analyzing the politics of school organizations, affirming a Weberian perspective as most appropriate. Develops "logic of action" (the implicit relationship between means and goals) as the focal point of organizational politics. Underlines the importance of analyzing interest groups and their strategies. Political…

Is a Scientific Classification of Educational (Behavioral) Objectives Possible?

ERIC Educational Resources Information Center

Stigliano, Tony

Robert M. W. Travers's 1980 essay is the focal point of this paper. He argues that evaluation research requires a scientific taxonomy of human behavior and learning. Such a taxonomy must be experimentally based, mathematically expressed, theoretically sound, and predictive. He bases such criteria on the development of scientifically successful…

The Feminists and Their Impact on the College Community

ERIC Educational Resources Information Center

Loeffler, Marcia

1975-01-01

As American women increasingly seek advanced education, they concurrently anticipate commensurate social recognition. Activist appeals and ensuing action are taking place within various feminist organizations. The unique attributes of women are the focal point in a variety of Womens Studies programs offered in our nation's colleges and…

Unveiling White Privilege.

ERIC Educational Resources Information Center

Pappas, Georgia

1995-01-01

Racism, discrimination, and prejudice are typically viewed from the perspective of the disadvantaged ethnic minority, but another approach is to address the advantages of whites. There is one culture that is usually invisible to whites, and that is "whiteness." To grow up white is to be the focal point from which others differ. Whites…

Understanding Policy Implementation: District-Level Leaders' Perceptions of Reading Policy Implementation Efforts

ERIC Educational Resources Information Center

Hall, Charles Dana

2013-01-01

Research investigating the complex, multi-directional relationships inherent to public education has become a focal point of reform research. This study investigated the perceptions held by district-level leaders regarding the Colorado Department of Education's efforts to facilitate the successful implementation of reading policy. In addition, it…

Focal adhesion interactions with topographical structures: a novel method for immuno-SEM labelling of focal adhesions in S-phase cells.

PubMed

Biggs, M J P; Richards, R G; Wilkinson, C D W; Dalby, M J

2008-07-01

Current understanding of the mechanisms involved in osseointegration following implantation of a biomaterial has led to adhesion quantification being implemented as an assay of cytocompatibility. Such measurement can be hindered by intra-sample variation owing to morphological changes associated with the cell cycle. Here we report on a new scanning electron microscopical method for the simultaneous immunogold labelling of cellular focal adhesions and S-phase nuclei identified by BrdU incorporation. Prior to labelling, cellular membranes are removed by tritonization and antigens of non-interest blocked by serum incubation. Adhesion plaque-associated vinculin and S-phase nuclei were both separately labelled with a 1.4 nm gold colloid and visualized by subsequent colloid enhancement via silver deposition. This study is specifically concerned with the effects microgroove topographies have on adhesion formation in S-phase osteoblasts. By combining backscattered electron (BSE) imaging with secondary electron (SE) imaging it was possible to visualize S-phase nuclei and the immunogold-labelled adhesion sites in one energy 'plane' and the underlying nanotopography in another. Osteoblast adhesion to these nanotopographies was ascertained by quantification of adhesion complex formation.

Study the efficacy of neuroprotective drugs on brain physiological properties during focal head injury using optical spectroscopy data analysis

NASA Astrophysics Data System (ADS)

Abookasis, David; Shochat, Ariel

2016-03-01

We present a comparative evaluation of five different neuroprotective drugs in the early phase following focal traumatic brain injury (TBI) in mouse intact head. The effectiveness of these drugs in terms of changes in brain tissue morphology and hemodynamic properties was experimentally evaluated through analysis of the optical absorption coefficient and spectral reduced scattering parameters in the range of 650-1000 nm. Anesthetized male mice (n=50 and n=10 control) were subjected to weight drop model mimics real life focal head trauma. Monitoring the effect of injury and neuroprotective drugs was obtained by using a diffuse reflectance spectroscopy system utilizing independent source-detector separation and location. Result indicates that administration of minocycline improve hemodynamic and reduced the level of tissue injury at an early phase post-injury while hypertonic saline treatment decrease brain water content. These findings highlight the heterogeneity between neuroprotective drugs and the ongoing controversy among researchers regarding which drug therapy is preferred for treatment of TBI. On the other hand, our results show the capability of optical spectroscopy technique to noninvasively study brain function following injury and drug therapy.

A Simple Rule for Dendritic Spine and Axonal Bouton Formation Can Account for Cortical Reorganization after Focal Retinal Lesions

PubMed Central

Butz, Markus; van Ooyen, Arjen

2013-01-01

Lasting alterations in sensory input trigger massive structural and functional adaptations in cortical networks. The principles governing these experience-dependent changes are, however, poorly understood. Here, we examine whether a simple rule based on the neurons' need for homeostasis in electrical activity may serve as driving force for cortical reorganization. According to this rule, a neuron creates new spines and boutons when its level of electrical activity is below a homeostatic set-point and decreases the number of spines and boutons when its activity exceeds this set-point. In addition, neurons need a minimum level of activity to form spines and boutons. Spine and bouton formation depends solely on the neuron's own activity level, and synapses are formed by merging spines and boutons independently of activity. Using a novel computational model, we show that this simple growth rule produces neuron and network changes as observed in the visual cortex after focal retinal lesions. In the model, as in the cortex, the turnover of dendritic spines was increased strongest in the center of the lesion projection zone, while axonal boutons displayed a marked overshoot followed by pruning. Moreover, the decrease in external input was compensated for by the formation of new horizontal connections, which caused a retinotopic remapping. Homeostatic regulation may provide a unifying framework for understanding cortical reorganization, including network repair in degenerative diseases or following focal stroke. PMID:24130472

DEEM, a versatile platform of FRD measurement for highly multiplexed fibre systems in astronomy

NASA Astrophysics Data System (ADS)

Yan, Yunxiang; Yan, Qi; Wang, Gang; Sun, Weimin; Luo, A.-Li; Ma, Zhenyu; Zhang, Qiong; Li, Jian; Wang, Shuqing

2018-06-01

We present a new method of DEEM, the direct energy encircling method, for characterizing the performance of fibres in most astronomical spectroscopic applications. It is a versatile platform to measure focal ratio degradation (FRD), throughput, and point spread function. The principle of DEEM and the relation between the encircled energy and the spot size were derived and simulated based on the power distribution model (PDM). We analysed the errors of DEEM and pointed out the major error source for better understanding and optimization. The validation of DEEM has been confirmed by comparing the results with conventional method which shows that DEEM has good robustness with high accuracy in both stable and complex experiment environments. Applications on the integral field unit (IFU) show that the FRD of 50 μm core fibre is substandard for the requirement which requires the output focal ratio to be slower than 4.5. The homogeneity of throughput is acceptable and higher than 85 per cent. The prototype IFU of the first generation helps to find out the imperfections to optimize the new design of the next generation based on the staggered structure with 35 μm core fibres of N.A. = 0.12, which can improve the FRD performance. The FRD dependence on wavelength and core size is revealed that higher output focal ratio occurs at shorter wavelengths for large core fibres, which is in agreement with the prediction of PDM. But the dependence of the observed data is weaker than the prediction.

Two-Point Orientation Discrimination Versus the Traditional Two-Point Test for Tactile Spatial Acuity Assessment

PubMed Central

Tong, Jonathan; Mao, Oliver; Goldreich, Daniel

2013-01-01

Two-point discrimination is widely used to measure tactile spatial acuity. The validity of the two-point threshold as a spatial acuity measure rests on the assumption that two points can be distinguished from one only when the two points are sufficiently separated to evoke spatially distinguishable foci of neural activity. However, some previous research has challenged this view, suggesting instead that two-point task performance benefits from an unintended non-spatial cue, allowing spuriously good performance at small tip separations. We compared the traditional two-point task to an equally convenient alternative task in which participants attempt to discern the orientation (vertical or horizontal) of two points of contact. We used precision digital readout calipers to administer two-interval forced-choice versions of both tasks to 24 neurologically healthy adults, on the fingertip, finger base, palm, and forearm. We used Bayesian adaptive testing to estimate the participants’ psychometric functions on the two tasks. Traditional two-point performance remained significantly above chance levels even at zero point separation. In contrast, two-point orientation discrimination approached chance as point separation approached zero, as expected for a valid measure of tactile spatial acuity. Traditional two-point performance was so inflated at small point separations that 75%-correct thresholds could be determined on all tested sites for fewer than half of participants. The 95%-correct thresholds on the two tasks were similar, and correlated with receptive field spacing. In keeping with previous critiques, we conclude that the traditional two-point task provides an unintended non-spatial cue, resulting in spuriously good performance at small spatial separations. Unlike two-point discrimination, two-point orientation discrimination rigorously measures tactile spatial acuity. We recommend the use of two-point orientation discrimination for neurological assessment. PMID:24062677

Search for Near-Earth Objects with Small Aphelion Distances

NASA Technical Reports Server (NTRS)

Tholen, David J.

2003-01-01

An essential component of our ability to efficiently find NEOs at small solar elongation is a focal reducer, whose construction is being separately funded by a grant from NSF. This focal reducer will increase the field of view of the 8k CCD mosaic camera from 19 arc min to about 32 arc min at the Cassegrain focus of the University of Hawaii 2.24-m telescope. As of January, all but one of the lenses for the focal reducer were in hand. The final lens had been delayed due to problems with the availability of the rather exotic material out of which the manufacturer was to fabricate the lens. Perhaps as a result of their rush to deliver that final lens, it developed a crack during the annealing process at the manufacturer, thus they had to start over. The total delay in delivery of that last lens was nearly ten months, and therefore the focal reducer was not completed on schedule and could not be used on the telescope this semester. A postdoctoral research associate was recruited to handle the day-to-day operations. The closing date for applications was 2002 December 3 1, and seven were received. One applicant was not qualified, and two were marginal. Of the four qualified candidates, Fabrizio Bernardi stood out as being best qualified. He was a student of Andrea Carusi and had worked on the CINEOS project in Italy, which includes a component of searching for NEOs at small solar elongations.

A focal plane detector design for a wide band Laue-lens telescope

NASA Astrophysics Data System (ADS)

Caroli, E.; Auricchio, N.; Bertuccio, G.; Budtz-Jørgensen, C.; Curado da Silva, R. M.; Del Sordo, S.; Frontera, F.; Quadrini, E.; Ubertini, P.; Ventura, G.

2006-06-01

The energy range above 50 keV is important for the study of many open problems in high energy astrophysics such as, non thermal mechanisms in SNR, the study of the high energy cut-offs in AGN spectra, and the detection of nuclear and annihilation lines. In the framework of the definition of a new mission concept for hard X and soft gamma ray (GRI- Gamma Ray Imager) for the next decade, the use of Laue lenses with broad energy band-passes from 100 to 1000 keV is under study. This kind of instruments will be used for deep study the hard X-ray continuum of celestial sources. This new telescope will require focal plane detectors with high detection efficiency over the entire operative range, an energy resolution of few keV at 500 keV and a sensitivity to linear polarization. We describe a possible configuration for the focal plane detector based on CdTe/CZT pixelated layers stacked together to achieve the required detection efficiency at high energy. Each layer can either operate as a separate position sensitive detector and a polarimeter or together with other layers in order to increase the overall full energy efficiency. We report on the current state of art in high Z spectrometers development and on some activities undergoing. Furthermore we describe the proposed focal plane option with the required resources and an analytical summary of the achievable performance in terms of efficiency and polarimetry.

Optimization of behavioural tests for the prediction of outcomes in mouse models of focal middle cerebral artery occlusion.

PubMed

Wen, Zhuoyu; Xu, Xiaomeng; Xu, Lili; Yang, Lian; Xu, Xiaohui; Zhu, Juehua; Wu, Li; Jiang, Yongjun; Liu, Xinfeng

2017-06-15

Intraluminal middle cerebral artery occlusion (MCAO) is the most widely used model of stroke. We aimed to predict the outcome of MCAO using a combination of fine behavioural tests for the prediction of unsuccessful surgery in mice leading to no infarction, haemorrhage and unexpected death. MCAO was performed on adult mice under the guidance of laser-Doppler flowmetry (LDF) to warrant a decrease in regional cerebral blood flow (rCBF) in the MCA territory. Four outcomes of MCAO were defined according to histological analysis: infarction, no infarction, haemorrhage and unexpected death (death within 24h post-surgery). Fine behavioural tests including the rotarod, modified neurological severity score (mNSS), Clark general and Clark focal tests were performed separately at 6h, 12h and 24h post-stroke. A total of 94 mice were included in the analysis. The infarction rate associated with MCAO was 58.5% (55/94). After optimization of the timing and behavioural tests, we found that higher Clark focal (>17.5) or higher mNSS scores (>10) were markedly related to early death, whereas a lower mNSS score (<3.5) was indicative of a tendency to show no infarction at 6h post-stroke. After 24h post-stroke, there was a positive correlation between the infarct volume and Clark focal results. Behavioural tests could help to predict the outcomes in the MCAO mouse model. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

’Systematic Watch’ in the Corps Rear Area

DTIC Science & Technology

1990-06-01

concealment, and to exploit the capabilities of existing rail, road and communications systems. However, urban areas may also be a focal point for activity...to encounter enemy activity in the rear area while moving supplies forward, operating a refueling point or evacuating equipment to the rear. These...ituc-cnii. w,,ct .e ,stng Cadt , gathe mg and " a ’,ntatng the data ne.ded. And COMDIetng And l’e e..n.; !e .c .on f infomation Send co-en,$ o srqg this

Buy Our Spares Smart Annual Report, Fiscal Year 1987.

DTIC Science & Technology

1988-01-19

by Mr. J. J. Genovese , serves as the single focal point for This annual report presents a detailed description implementing and guiding Project BOSS...participating commands or making 43 lyl’e ) p I 4COMPETITION CONTACT POINTS COMMAND ADVOCATE TELEPHONE Naval Supply Systems Command Mr. J.J. Genovese A...20) MMI Laredo Bell MM3 Frederick R. Schnieder STGI Michael D. Fleming EW3 David J. Shallo LT Jeffrey J. Grabarek BT2 Marshall L. Vorhies USS KITTY

Kernel Ada Programming Support Environment (KAPSE) Interface Team: Public Report. Volume II.

DTIC Science & Technology

1982-10-28

essential I parameters from our work so far in this area and, using trade-offs concerning these, construct the KIT’s recommended alternative. 1145...environment that are also in the development states. At this point in development it is essential for the KITEC to provide a forum and act as a focal...standardization in this area. Moreover, this is an area with considerable divergence in proposed approaches. Or the other hand, an essential tool from the point of

National Center for Standards and Certification Information: Service and programs

NASA Technical Reports Server (NTRS)

Overman, Joanne

1994-01-01

The National Center for Standards and Certification Information (NCSCI) provides information on U.S., foreign and international voluntary standards, government regulations, and conformity assessment procedures for non-agricultural products. The Center serves as a referral service and focal point in the United States for information on standards and standards-related information. NCSCI staff respond to inquiries, maintain a reference collection of standards and standards-related documents, and serve as the U.S. inquiry point for information to and from foreign countries.

Changes in retinal venular oxygen saturation predict activity of proliferative diabetic retinopathy 3 months after panretinal photocoagulation.

PubMed

Torp, Thomas Lee; Kawasaki, Ryo; Wong, Tien Yin; Peto, Tunde; Grauslund, Jakob

2018-03-01

Proliferative diabetic retinopathy (PDR) is a severe blinding condition. We investigated whether retinal metabolism, measured by retinal oximetry, may predict PDR activity after panretinal laser photocoagulation (PRP). We performed a prospective, interventional, clinical study of patients with treatment-naive PDR. Wide-field fluorescein angiography (OPTOS, Optomap) and global and focal retinal oximetry (Oxymap T1) were performed at baseline (BL), and 3 months (3M) after PRP. Angiographic findings were used to divide patients according to progression or non-progression of PDR after PRP. We evaluated differences in global and focal retinal oxygen saturation between patients with and without progression of PDR after PRP treatment. We included 45 eyes of 37 patients (median age and duration of diabetes were 51.6 and 20 years). Eyes with progression of PDR developed a higher retinal venous oxygen saturation than eyes with non-progression at 3M (global: +5.9% (95% CI -1.5 to 12.9), focal: +5.4%, (95% CI -4.1 to 14.8)). Likewise, progression of PDR was associated with a lower arteriovenular (AV) oxygen difference between BL and 3M (global: -6.1%, (95% CI -13.4 to -1.4), focal: -4.5% (95% CI -12.1 to 3.2)). In a multiple logistic regression model, increment in global retinal venular oxygen saturation (OR 1.30 per 1%-point increment, p=0.017) and decrement in AV oxygen saturation difference (OR 0.72 per 1%-point increment, p=0.016) at 3M independently predicted progression of PDR. Development of higher retinal venular and lower AV global oxygen saturation independently predicts progression of PDR despite standard PRP and might be a potential non-invasive marker of angiogenic disease activity. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

An automated optimization tool for high-dose-rate (HDR) prostate brachytherapy with divergent needle pattern

NASA Astrophysics Data System (ADS)

Borot de Battisti, M.; Maenhout, M.; de Senneville, B. Denis; Hautvast, G.; Binnekamp, D.; Lagendijk, J. J. W.; van Vulpen, M.; Moerland, M. A.

2015-10-01

Focal high-dose-rate (HDR) for prostate cancer has gained increasing interest as an alternative to whole gland therapy as it may contribute to the reduction of treatment related toxicity. For focal treatment, optimal needle guidance and placement is warranted. This can be achieved under MR guidance. However, MR-guided needle placement is currently not possible due to space restrictions in the closed MR bore. To overcome this problem, a MR-compatible, single-divergent needle-implant robotic device is under development at the University Medical Centre, Utrecht: placed between the legs of the patient inside the MR bore, this robot will tap the needle in a divergent pattern from a single rotation point into the tissue. This rotation point is just beneath the perineal skin to have access to the focal prostate tumor lesion. Currently, there is no treatment planning system commercially available which allows optimization of the dose distribution with such needle arrangement. The aim of this work is to develop an automatic inverse dose planning optimization tool for focal HDR prostate brachytherapy with needle insertions in a divergent configuration. A complete optimizer workflow is proposed which includes the determination of (1) the position of the center of rotation, (2) the needle angulations and (3) the dwell times. Unlike most currently used optimizers, no prior selection or adjustment of input parameters such as minimum or maximum dose or weight coefficients for treatment region and organs at risk is required. To test this optimizer, a planning study was performed on ten patients (treatment volumes ranged from 8.5 cm3to 23.3 cm3) by using 2-14 needle insertions. The total computation time of the optimizer workflow was below 20 min and a clinically acceptable plan was reached on average using only four needle insertions.

A novel mouse model of podocyte depletion

PubMed Central

Wang, L.; Tang, Y.; Howell, D.N.; Ruiz, P.; Spurney, R.F.

2013-01-01

Aim The goal of these studies was to examine the capacity for glomerular repair after a podocyte depleting injury. Methods We created transgenic (TG) mice expressing the yeast enzyme cytosine deaminase specifically in glomerular podocytes. In these TG animals, the prodrug 5-flucytosine (5-FC) is converted to 5-fluorouracil (5-FU) and promotes cell death. Results Treatment with increasing dosages of 5-FC caused graded increases in proteinuria 1–2 weeks after treatment, which returned to control levels by the 10-week time point. Light microscopic examination revealed minimal pathology at the 2-week time point, but electron microscopy revealed found foot process effacement as well as focal areas of glomerular basement membrane duplication, and immunohistochemical studies detected podocyte apoptosis and a decrease in the number of Wilms tumor protein 1 (WT1) positive cells. By the 10-week time point, however, the number of WT1 positive cells was similar to controls and a few mice had developed focal areas of glomerulosclerosis. Consistent with the effects of 5-FC on podocyte number, expression of the podocyte mRNAs for nephrin, podocin, synaptopodin and podocalyxin were altered in a similar temporal fashion. Conclusion The glomerulus has a significant capacity for repair after a podocyte depleting injury. PMID:23095233

Laser focus compensating sensing and imaging device

DOEpatents

Vann, Charles S.

1993-01-01

A laser focus compensating sensing and imaging device permits the focus of a single focal point of different frequency laser beams emanating from the same source point. In particular it allows the focusing of laser beam originating from the same laser device but having differing intensities so that a low intensity beam will not convert to a higher frequency when passing through a conversion crystal associated with the laser generating device. The laser focus compensating sensing and imaging device uses a cassegrain system to fold the lower frequency, low intensity beam back upon itself so that it will focus at the same focal point as a high intensity beam. An angular tilt compensating lens is mounted about the secondary mirror of the cassegrain system to assist in alignment. In addition cameras or CCD's are mounted with the primary mirror to sense the focused image. A convex lens is positioned co-axial with the cassegrain system on the side of the primary mirror distal of the secondary for use in aligning a target with the laser beam. A first alternate embodiment includes a cassegrain system using a series of shutters and an internally mounted dichroic mirror. A second alternate embodiment uses two laser focus compensating sensing and imaging devices for aligning a moving tool with a work piece.

Laser focus compensating sensing and imaging device

DOEpatents

Vann, C.S.

1993-08-31

A laser focus compensating sensing and imaging device permits the focus of a single focal point of different frequency laser beams emanating from the same source point. In particular it allows the focusing of laser beam originating from the same laser device but having differing intensities so that a low intensity beam will not convert to a higher frequency when passing through a conversion crystal associated with the laser generating device. The laser focus compensating sensing and imaging device uses a Cassegrain system to fold the lower frequency, low intensity beam back upon itself so that it will focus at the same focal point as a high intensity beam. An angular tilt compensating lens is mounted about the secondary mirror of the Cassegrain system to assist in alignment. In addition cameras or CCD's are mounted with the primary mirror to sense the focused image. A convex lens is positioned co-axial with the Cassegrain system on the side of the primary mirror distal of the secondary for use in aligning a target with the laser beam. A first alternate embodiment includes a Cassegrain system using a series of shutters and an internally mounted dichroic mirror. A second alternate embodiment uses two laser focus compensating sensing and imaging devices for aligning a moving tool with a work piece.

Added Value of Contrast-Enhanced Ultrasound on Biopsies of Focal Hepatic Lesions Invisible on Fusion Imaging Guidance.

PubMed

Kang, Tae Wook; Lee, Min Woo; Song, Kyoung Doo; Kim, Mimi; Kim, Seung Soo; Kim, Seong Hyun; Ha, Sang Yun

2017-01-01

To assess whether contrast-enhanced ultrasonography (CEUS) with Sonazoid can improve the lesion conspicuity and feasibility of percutaneous biopsies for focal hepatic lesions invisible on fusion imaging of real-time ultrasonography (US) with computed tomography/magnetic resonance images, and evaluate its impact on clinical decision making. The Institutional Review Board approved this retrospective study. Between June 2013 and January 2015, 711 US-guided percutaneous biopsies were performed for focal hepatic lesions. Biopsies were performed using CEUS for guidance if lesions were invisible on fusion imaging. We retrospectively evaluated the number of target lesions initially invisible on fusion imaging that became visible after applying CEUS, using a 4-point scale. Technical success rates of biopsies were evaluated based on histopathological results. In addition, the occurrence of changes in clinical decision making was assessed. Among 711 patients, 16 patients (2.3%) were included in the study. The median size of target lesions was 1.1 cm (range, 0.5-1.9 cm) in pre-procedural imaging. After CEUS, 15 of 16 (93.8%) focal hepatic lesions were visualized. The conspicuity score was significantly increased after adding CEUS, as compared to that on fusion imaging (p < 0.001). The technical success rate of biopsy was 87.6% (14/16). After biopsy, there were changes in clinical decision making for 11 of 16 patients (68.8%). The addition of CEUS could improve the conspicuity of focal hepatic lesions invisible on fusion imaging. This dual guidance using CEUS and fusion imaging may affect patient management via changes in clinical decision-making.

In Vivo Determination of the Complex Elastic Moduli of Cetacean Head Tissue

DTIC Science & Technology

2014-09-30

testing on Navy dolphins and stranded animals, for which permits and approvals have been obtained. 3 WORK COMPLETED System Design A prototype...chosen for the prototype system’s focal length. This would allow examination of brain tissue in a typical adult bottlenose dolphin , which is the...those observed in preliminary in vivo experiments (conducted under a separate effort) on two bottlenose dolphins and one beluga whale. System

On the Quality of Point-Clouds Derived from Sfm-Photogrammetry Applied to UAS Imagery

NASA Astrophysics Data System (ADS)

Carbonneau, P.; James, T.

2014-12-01

Structure from Motion photogrammetry (SfM-photogrammetry) recently appeared in environmental sciences as an impressive tool allowing for the creation of topographic data from unstructured imagery. Several authors have tested the performance of SfM-photogrammetry vs that of TLS or dGPS. Whilst the initial results were very promising, there is currently a growing awareness that systematic deformations occur in DEMs and point-clouds derived from SfM-photogrammetry. Notably, some authors have identified a systematic doming manifest as an increasing error vs distance to the model centre. Simulation studies have confirmed that this error is due to errors in the calibration of camera distortions. This work aims to further investigate these effects in the presence of real data. We start with a dataset of 220 images acquired from a sUAS. After obtaining an initial self-calibration of the camera lens with Agisoft Photoscan, our method consists in applying systematic perturbations to 2 key lens parameters: Focal length and the k1 distortion parameter. For each perturbation, a point-cloud was produced and compared to LiDAR data. After deriving the mean and standard deviation of the error residuals (ɛ), a 2nd order polynomial surface was fitted to the errors point-cloud and the peak ɛ defined as the mathematical extrema of this surface. The results are presented in figure 1. This figure shows that lens perturbations can induce a range of errors with systematic behaviours. Peak ɛ is primarily controlled by K1 with a secondary control exerted by the focal length. These results allow us to state that: To limit the peak ɛ to 10cm, the K1 parameter must be calibrated to within 0.00025 and the focal length to within 2.5 pixels (≈10 µm). This level of calibration accuracy can only be achieved with proper design of image acquisition and control network geometry. Our main point is therefore that SfM is not a bypass to a rigorous and well-informed photogrammetric approach. Users of SfM-photogrammetry will still require basic training and knowledge in the fundamentals of photogrammetry. This is especially true for applications where very small topographic changes need to be detected or where gradient-sensitive processes need to be modelled.

Social Policy as Social Process. Final Report.

ERIC Educational Resources Information Center

Newitt, Jane

A decade's explosive growth in the scope, funding and complexity of national social policy has created serious problems in the United States. This first overview report notes that the Office of Economic Opportunity (now known as the Community Services Administration) has ceased to provide a focal point for national social policy. It was this state…

Balanced Development for Provincial-Level Coordination and Higher Vocational Education

ERIC Educational Resources Information Center

Po, Yang; Yunbo, Liu

2017-01-01

In the rapid development of Chinese higher vocational education, large gaps have appeared in the scale of development and resource generation among the provinces, among regions in the provinces, and among higher education institutions in the provinces. Balanced regional development and provincial-level coordination have become policy focal points,…

TVET Teacher Education on the Threshold of Internationalisation

ERIC Educational Resources Information Center

Bunning, Frank, Ed.; Zhao, Zhi-Qun, Ed.

2006-01-01

The UNESCO International Meeting on Innovation and Excellence in TVET Teacher Education took place in Hangzhou/China in November 2004. The main aim of this conference was to establish a platform for discussion about improving the quality of Technical and Vocational Education and Training (TVET). The focal point was the development and…

Physical Education, Sport and Recreation: A Triad Pedagogy of Hope

ERIC Educational Resources Information Center

van Deventer, K. J.

2011-01-01

Bloch (2009, 58), a previous advocate of Outcomes-based Education (OBE), states that "schooling in SA" is a national disaster. Quality holistic education that includes Physical Education (PE) and school sport should be the focal point of progress in developing countries. However, PE is worldwide in a political crisis and the situation is…

Head, Heart, and Hands for Our Youngest Children.

ERIC Educational Resources Information Center

Southeastern Regional Vision for Education (SERVE), Tallahassee, FL.

This document details a strategy to bring together state and community leaders in the southeastern United States to establish dialogue, set priorities, and make system-wide changes for supporting literacy for the youngest children and their families. The Head, Heart, and Hands campaign has three focal points: (1) Head--understanding research and…

Developing Secure Agent Systems Using Delegation Based Trust Management

DTIC Science & Technology

2005-01-01

delegation rules, so that the information in the SCM may be accessed only by authorized agents. Special intelligent agents called security agents are re... Bluetooth , IEEE 802.11, or Infrared, via any hand-held device, within a Vigil can also be used in wired systems, but the focal point of our re- search is

An Analysis of Informal Reasoning Fallacy and Critical Thinking Dispositions among Malaysian Undergraduates

ERIC Educational Resources Information Center

Ramasamy, Shamala

2011-01-01

In this information age, the amount of complex information available due to technological advancement would require undergraduates to be extremely competent in processing information systematically. Critical thinking ability of undergraduates has been the focal point among educators, employers and the public at large. One of the dimensions of…

English Language Teachers' Ideology of ELT Assessment Literacy

ERIC Educational Resources Information Center

Hakim, Badia

2015-01-01

Deep understanding, clear perception and accurate use of assessment methodology play an integral role in the success of a language program. Use of various assessment techniques to evaluate and improve the performance of learners has been the focal point of interest in the field of English Language Teaching (ELT). Equally researchers are interested…

77 FR 23250 - Statement of Organization, Functions, and Delegations of Authority; Administration for Community...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Community Living (ACL) provides national leadership and direction to plan, manage, develop, and raise... Management and Budget (BE) B.20 Functions. ACL is the principal agency designated to lead aging and... executive direction, leadership, and guidance for ACL programs, and serves as the focal point for the...

REFLECTION AND REFRACTION, VOLUME 2.

ERIC Educational Resources Information Center

KLAUS, DAVID J.; AND OTHERS

THIS VOLUME 2 OF A TWO-VOLUME SET PROVIDES AUTOINSTRUCTION IN PHYSICS. THE UNITS COVERED IN THIS VOLUME ARE (1) REFLECTION OF LIGHT, (2) PHOTOMETRY, (3) POLARIZATION, (4) REFRACTION OF LIGHT, (5) SNELL'S LAW, (6) LENSES, FOCUS, AND FOCAL POINTS, (7) IMAGE FORMATION, AND (8) ABERRATIONS, THE EYE, AND MAGNIFICATION. THE INTRODUCTION AND UNITS ON…

Relationship between Teacher Self-Efficacy and the Teacher Evaluation Process

ERIC Educational Resources Information Center

Pisciotta, Summer

2014-01-01

Changes in state laws led the education system personnel in Arizona to reconsider how they assess students, teachers, and administrators. Higher expectations for teacher and student performance and a budget deficit at schools resulted in evaluations being a focal point in teacher contract renewal. The purpose of this qualitative case study was to…

Learning Approaches and Cultural Influences: A Comparative Study of Confucian and Western-Heritage Students

ERIC Educational Resources Information Center

Dennehy, Edward

2015-01-01

With the advent of increasingly multinational student cohorts in many higher education institutes, the possible influence of 'national culture' on students' learning approaches has become a focal point of attention. In particular, the claim that Asian (Confucian) students adopt (primarily) surface learning approaches has attracted much debate…

76 FR 61106 - Notice of Intent To Prepare an Environmental Impact Statement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-03

... Environmental Protection, Office of Research Facilities, NIH, B13/2S11, 9000 Rockville Pike, Bethesda, Maryland... Institutes of Health (NIH), one of the world's largest biomedical research facilities and the Federal government's focal point for medical and behavioral research. The NIH Animal Center at Poolesville is a major...

Teacher Evaluation: Principals' Insights and Suggestions for Improvement

ERIC Educational Resources Information Center

Kersten, Thomas A.; Israel, Marla S.

2005-01-01

In the twenty-first century, school improvement is the focal point for educational leadership, in which the school building administrator is recognized as the catalyst for this necessary improvement. Within the area of teacher evaluation, the evaluation tools, along with the amount of time, format, and feedback, have changed dramatically from the…

Romani Culture and Academic Success: Arguments against the Belief in a Contradiction

ERIC Educational Resources Information Center

Brüggemann, Christian

2014-01-01

Roma, today perceived as the most numerous European minority, face marginalisation and exclusion. Education is considered to be one of the focal points for improvement, and numerous studies have analysed and reported on the educational situation of Roma. Several studies have argued that Romani cultural values are not compatible with institutional…

Inclusive Education: Proclamations or Reality (Primary School Teachers' View)

ERIC Educational Resources Information Center

Slavica, Pavlovic

2010-01-01

This paper deals with 2 focal points of inclusive education, which is the integral segment of the current education reform in the Bosnia and Herzegovina: its position in various proclamations and in primary school teachers' reality, i.e., legislative aspects vs. everyday situation in primary schools. The survey research was carried out through the…

Missing--The People's Voice: Organisation for Economic Co-Operation and Development

ERIC Educational Resources Information Center

Pike, Patricia

2014-01-01

Sustainable development in education for future economic growth has always been a global focal point for non-governmental agencies across the world. This article highlights the extensive work the Organisation for Economic Co-operation Development (OECD) has achieved over time, constructing contemporary society as we know it today, continually…

New To Teaching: "Vegecating" Children

ERIC Educational Resources Information Center

Bagshaw, Katherine; Barham, Hannah; Betts, Rebecca; Felton, Amie; Knatt, Joshua

2014-01-01

Student teachers, Katherine Bagshaw, Hannah Barham, Rebecca Betts, Amie Felton and Joshua Knatt, share their ideas on how to bridge the gap between statutory and non-statutory guidelines for food and nutrition with 8- to 10-year-olds. The teachers realized the health of children has become a focal point of concern for both parents and education…

Here's How You Can Carry On the Fight against Epidemics in Your Schools.

ERIC Educational Resources Information Center

Hickson, Meredith Ann; Hinman, Alan R.

1983-01-01

During the 1970's many children lacked immunization against one or more of the major childhood diseases. Recently the number of cases of childhood diseases has declined dramatically. The schools are the focal point for disease prevention. Outlined are 10 steps to continue to ensure childrens' health. (MD)

The History Teacher as Propagandist

ERIC Educational Resources Information Center

Birn, Donald S.

1972-01-01

During the post war years the League of Nations Union Movement in Britain worked through the schools and converted pro-league sentiment into specific government policies. The history classroom was the focal point of the L.N.U.'s educational effort so that new generations would grow up ready to support enlightened foreign policies and the work of…

A New Eye on History

ERIC Educational Resources Information Center

Galuszka, Peter

2010-01-01

Two years after the opening of the National Underground Railroad Freedom Center, the $110 million center, opened with exhibits on how enslaved African-Americans risked their lives to make the northward trek to freedom. Today, however, the center is shifting its focus while serving as an educational focal point, research asset and change agent.…

Biotechnology Process Engineering Center at MIT Home

Science.gov Websites

has provided a focal point for biotechnology research and education at MIT. Prominent examples include to be one of the most crucial interdisciplinary research centers connected to BE; a significant and providing support for research and education at the nexus of biology, engineering, and materials

The Star Schools Distance-Learning Program: Results from the Mandated Study.

ERIC Educational Resources Information Center

Tushnet, Naida C.; And Others

The Star Schools Assistance Program has been funding activities since 1988. It provides projects with seed money to develop distance learning programming and equip sites. In addition, Star Schools has served as a focal point for demonstrating innovative uses of technology to advance educational opportunity and improvement. This paper represents…

Ribose 5-Phosphate Isomerase Investigations for the Undergraduate Biochemistry Laboratory

ERIC Educational Resources Information Center

Jewett, Kathy; Sandwick, Roger K.

2011-01-01

The enzyme ribose 5-phosphate isomerase (RpiA) has many features that make it attractive as a focal point of a semester-long, advanced biochemistry laboratory for undergraduate students. The protein can easily and inexpensively be isolated from spinach using traditional purification techniques. Characterization of RpiA enzyme activity can be…

77 FR 14319 - Unmanned Aircraft System Test Sites

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... DoD and NASA. A project at a test range (a defined geographic area where research and development are..., the FAA believes that the new test sites need to include focal points to ensure that research is... and experience in conducting UAS operations and research. Methods that test site operators can use for...

Contemporary Art and Multicultural Education.

ERIC Educational Resources Information Center

Cahan, Susan, Ed.; Kocur, Zoya, Ed.

As a curriculum guide for high school teachers and students, this volume is a natural outgrowth of the philosophy of the New Museum of Contemporary Art. It provides thought-provoking and innovative materials that challenge the normative practice of art education and art history. Contemporary art is used as the focal point for an antiracist,…

Threshold Concepts as Focal Points for Supporting Student Learning

ERIC Educational Resources Information Center

Jordan, Katy; Tracy, Frances; Johnstone, Keith

2011-01-01

The Plant Sciences Pedagogy Project conducted research into undergraduate teaching and learning in the Department of Plant Sciences at the University of Cambridge and has translated the research findings into interventions to improve support for student learning. A key research objective for the project was to investigate how teachers within the…

Libraries for the Blind in the Russian Soviet Federal Socialist Republic.

ERIC Educational Resources Information Center

Zarkov, D. S.

1981-01-01

This overview of the development of a system of library services for the blind in one union republic of the USSR describes the centralized network of special libraries which serve as the focal point of systems providing services at the regional and local levels, and suggests some possible future developments. (RAA)

Incorporating Intercultural Communication Activities in English Language Classes

ERIC Educational Resources Information Center

Velasco, Daniel

2017-01-01

Intercultural Communication has become a relevant focal point within a variety of fields--science, psychology, politics, journalism, economics, and education, to name a few. Yet, current university students may not even be aware of Intercultural Communication's role in these fields, as well as their studies and future careers. A survey was first…

The Rules of Engagement

ERIC Educational Resources Information Center

Raths, David

2013-01-01

There is a civil war simmering in classrooms nationwide. Arrayed on one side are students who would sooner cut off an arm than sacrifice their mobile devices. On the other stand faculty members who expect to be the focal point of their classes and will not abide distractions. Caught in the crossfire are instructional technology professionals.…

33 CFR 1.05-5 - Marine Safety and Security Council.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marine Safety and Security... SECURITY GENERAL GENERAL PROVISIONS Rulemaking § 1.05-5 Marine Safety and Security Council. The Marine... Commandant and is the focal point of the Coast Guard regulatory system. The Marine Safety and Security...

33 CFR 1.05-5 - Marine Safety and Security Council.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marine Safety and Security... SECURITY GENERAL GENERAL PROVISIONS Rulemaking § 1.05-5 Marine Safety and Security Council. The Marine... Commandant and is the focal point of the Coast Guard regulatory system. The Marine Safety and Security...

33 CFR 1.05-5 - Marine Safety and Security Council.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marine Safety and Security... SECURITY GENERAL GENERAL PROVISIONS Rulemaking § 1.05-5 Marine Safety and Security Council. The Marine... Commandant and is the focal point of the Coast Guard regulatory system. The Marine Safety and Security...

33 CFR 1.05-5 - Marine Safety and Security Council.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marine Safety and Security... SECURITY GENERAL GENERAL PROVISIONS Rulemaking § 1.05-5 Marine Safety and Security Council. The Marine... Commandant and is the focal point of the Coast Guard regulatory system. The Marine Safety and Security...

Influence of Spirituality, Family, and Self Efficacy on Teacher Effectiveness

ERIC Educational Resources Information Center

Heffner, Judith Maples

2016-01-01

Spirituality, family influence, and teacher efficacy are the focal points of this research project. Research supports family influence as a powerful support in career selection and the positive effects spirituality has on a teacher's personal and professional life. Self efficacy possessed by a teacher gives them an "I can do attitude."…

Helmdon's First Rainforest

ERIC Educational Resources Information Center

Blackburn, Sue

2003-01-01

This article describes how Helmdon Primary School is transformed in a memorable learning experience. It started out as a simple idea, a whole-school art exhibition centred on the theme of a tropical rainforest. The focal point was to be a life-sized rainforest created using a variety of media in the school hall. The school wanted the children to…

Fishing in Puddles: Place and Space in Performance Research

ERIC Educational Resources Information Center

Piasecka, Shelley

2014-01-01

This article examines the significance of place and space from a Performance Studies and Social Studies perspective. In terms of the social sciences, I draw upon the formal, symbolic and marginal articulation of place. Hetherington suggests that certain places act as focal point for the establishment of social identities, citing city-centre…

Ku I Ke Ao: Hawaiian Cultural Identity and Student Progress at Kamehameha Elementary School

ERIC Educational Resources Information Center

Stender, Robert Holoua

2010-01-01

The relationship between Hawaiian cultural identity and student progress at Kamehameha Elementary School (KES) is the focal point of this study. As the student demographics continue to evolve at Kamehameha Schools, most recently with increasing numbers of children coming from orphan and indigent backgrounds, teachers want greater understanding of…

Many Ways to Make A Line

ERIC Educational Resources Information Center

Ferrell, Holly

2006-01-01

This article describes a middle school introductory art lesson that encourages experimentation as an essential part of the creative process. In this lesson, students experiment with different types of media and tools to create an abstract piece that focuses on the most basic element of art--line. Students focus on line quality, focal points,…

Gaming Redefines Interactivity for Learning

ERIC Educational Resources Information Center

DeKanter, Nick

2005-01-01

The new definition of interactivity has as its focal point the skills of people, not the capabilities of the technology. The goal is to enhance the interaction between people and the learning that can only occur among curious and motivated individuals working together. The social nature of people, the increasing capabilities of technology and the…

Experience on Mashup Development with End User Programming Environment

ERIC Educational Resources Information Center

Yue, Kwok-Bun

2010-01-01

Mashups, Web applications integrating data and functionality from other Web sources to provide a new service, have quickly become ubiquitous. Because of their role as a focal point in three important trends (Web 2.0, situational software applications, and end user development), mashups are a crucial emerging technology for information systems…

A Study of North Carolina Technology Teacher Evaluation Practices and Job Satisfaction

ERIC Educational Resources Information Center

Olah, Dean Anthony

2013-01-01

Defining and measuring teacher effectiveness is one of the most hotly debated topics in public education today. The "No Child Left Behind" Act placed considerable emphasis on high quality teaching standards, making it a focal point of study among educators, administrators, and curriculum developers. Recruitment and retention of high…

Welcome to Our Web: Integrating Subjects through Entomology.

ERIC Educational Resources Information Center

Tevebaugh, Tara

2001-01-01

Shares how the study of insects became a focal point for cross-curricular convergence in the author's classroom. Describes the design of a unit of study that focused on entomology but integrated academic areas, especially language arts. Concludes that students must develop a sense of interdependence and an understanding of possible relationships…

Oak policy and management in California: Spanish origins and future considerations

Treesearch

James W. Bartolome; Lynn Huntsinger

2015-01-01

The development of goals and policies for Californian oak woodlands is reviewed; then some important considerations for future policy development are highlighted. California and Spain share long and illuminating histories of human interaction with oak woodlands. The Integrated Hardwood Range Management Program, initiated about 1985, was a focal point for Californian...

Identifying and Investigating Difficult Concepts in Engineering Mechanics and Electric Circuits. Research Brief

ERIC Educational Resources Information Center

Streveler, Ruth; Geist, Monica; Ammerman, Ravel; Sulzbach, Candace; Miller, Ronald; Olds, Barbara; Nelson, Mary

2007-01-01

This study extends ongoing work to identify difficult concepts in thermal and transport science and measure students' understanding of those concepts via a concept inventory. Two research questions provided the focal point: "What important concepts in electric circuits and engineering mechanics do students find difficult to learn?" and…

Examining Heterogeneity in the Effect of Taking Algebra in Eighth Grade

ERIC Educational Resources Information Center

Rickles, Jordan H.

2013-01-01

Increased access to algebra was a focal point of the National Mathematics Advisory Panel's 2008 report on improving mathematics learning in the United States. Past research found positive effects for early access to algebra, but the focus on average effects may mask important variation across student subgroups. The author addresses whether these…

Literature Ladders: Linking Books and Internet Resources.

ERIC Educational Resources Information Center

Lamb, Annette

2001-01-01

Describes Literature Learning Ladders, a project that uses books for children and young adults as the focal point for technology-rich thematic activities. Explains the use of Internet Web sites to find book information as well as sties that demonstrate how resources can be used as part of technology-based classroom activities. (LRW)

Pre-Service Teachers' Computational Knowledge, Efficacy, and Number Sense Skills

ERIC Educational Resources Information Center

Hinton, Vanessa

2011-01-01

The National Council of Teachers of Mathematics (NCTM) Curriculum Focal Points (2006) suggested heavy emphasis on instruction in whole numbers for young elementary students. Any intervention curriculum for students who are at-risk for mathematic difficulties should not be oversimplified. Number sense was defined by Berch (1998) as a developing…

"The Capture:" Kidnapping Students' Interests Using the "Guardians of Ga'Hoole"

ERIC Educational Resources Information Center

Bradbury, Leslie; Frye, Beth; Gross, Lisa

2013-01-01

This project describes a fourth-grade unit that integrated science and language arts using the book "The Capture" as a focal point. During the unit, students engaged in science activities and language arts lessons that focused on owls. Students conducted investigations that helped them develop a deeper understanding of the adaptations of…

Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins

NASA Technical Reports Server (NTRS)

Alenghat, Francis J.; Ingber, Donald E.

2002-01-01

Mechanical stresses modulate cell function by either activating or tuning signal transduction pathways. Mechanotransduction, the process by which cells convert mechanical stimuli into a chemical response, occurs both in cells specialized for sensing mechanical cues and in parenchymal cells whose primary function is not mechanosensory. However, common among the various responses to mechanical stress is the importance of direct or indirect connections between the internal cytoskeleton, the extracellular matrix (ECM), and traditional signal transducing molecules. In many instances, these elements converge at focal adhesions, sites of structural attachment between the cytoskeleton and ECM that are anchored by cell surface integrin receptors. Alenghat and Ingber discuss the accumulating evidence for the central role of cytoskeleton, ECM, and integrin-anchored focal adhesions in several mechanotransduction pathways.

ApcMin, A Mutation in the Murine Apc Gene, Predisposes to Mammary Carcinomas and Focal Alveolar Hyperplasias

NASA Astrophysics Data System (ADS)

Moser, Amy Rapaich; Mattes, Ellen M.; Dove, William F.; Lindstrom, Mary J.; Haag, Jill D.; Gould, Michael N.

1993-10-01

ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.

On-orbit calibration for star sensors without priori information.

PubMed

Zhang, Hao; Niu, Yanxiong; Lu, Jiazhen; Zhang, Chengfen; Yang, Yanqiang

2017-07-24

The star sensor is a prerequisite navigation device for a spacecraft. The on-orbit calibration is an essential guarantee for its operation performance. However, traditional calibration methods rely on ground information and are invalid without priori information. The uncertain on-orbit parameters will eventually influence the performance of guidance navigation and control system. In this paper, a novel calibration method without priori information for on-orbit star sensors is proposed. Firstly, the simplified back propagation neural network is designed for focal length and main point estimation along with system property evaluation, called coarse calibration. Then the unscented Kalman filter is adopted for the precise calibration of all parameters, including focal length, main point and distortion. The proposed method benefits from self-initialization and no attitude or preinstalled sensor parameter is required. Precise star sensor parameter estimation can be achieved without priori information, which is a significant improvement for on-orbit devices. Simulations and experiments results demonstrate that the calibration is easy for operation with high accuracy and robustness. The proposed method can satisfy the stringent requirement for most star sensors.

Observation of interaction of shock wave with gas bubble by image converter camera

NASA Astrophysics Data System (ADS)

Yoshii, M.; Tada, M.; Tsuji, T.; Isuzugawa, Kohji

1995-05-01

When a spark discharge occurs at the first focal point of a semiellipsoid or a reflector located in water, a spherical shock wave is produced. A part of the wave spreads without reflecting on the reflector and is called direct wave in this paper. Another part reflects on the semiellipsoid and converges near the second focal point, that is named the focusing wave, and locally produces a high pressure. This phenomenon is applied to disintegrators of kidney stone. But it is concerned that cavitation bubbles induced in the body by the expansion wave following the focusing wave will injure human tissue around kidney stone. In this paper, in order to examine what happens when shock waves strike bubbles on human tissue, the aspect that an air bubble is truck by the spherical shock wave or its behavior is visualized by the schlieren system and its photographs are taken using an image converter camera. Besides,the variation of the pressure amplitude caused by the shock wave and the flow of water around the bubble is measured with a pressure probe.

Field testing of a convergent array of acoustic Doppler profilers for high-resolution velocimetry in energetic tidal currents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harding, Samuel F.; Sellar, Brian; Richmond, Marshall C.

An array of single-beam acoustic Doppler profilers has been developed for the high resolution measurement of three-dimensional tidal flow velocities and subsequently tested in an energetic tidal site. This configuration has been developed to increase spatial resolution of velocity measurements in comparison to conventional acoustic Doppler profilers (ADPs) which characteristically use divergent acoustic beams emanating from a single instrument. This is achieved using geometrically convergent acoustic beams creating a sample volume at the focal point of 0.03 m3. Away from the focal point, the array is also able to simultaneously reconstruct three-dimensional velocity components in a profile throughout the watermore » column, and is referred to herein as a convergent-beam acoustic Doppler profiler (C-ADP). Mid-depth profiling is achieved through integration of the sensor platform with the operational commercial-scale Alstom 1MW DeepGen-IV Tidal Turbine deployed at the European Marine Energy Center, Orkney Isles, UK. This proof-of-concept paper outlines the C-ADP system configuration and comparison to measurements provided by co-installed reference instrumentation.« less

Plasma Channel Lenses and Plasma Tornadoes for Optical Beam Focusing and Transport

NASA Astrophysics Data System (ADS)

Hubbard, R. F.; Kaganovich, D.; Johnson, L. A.; Gordon, D. F.; Penano, J. R.; Hafizi, B.; Helle, M. H.; Mamonau, A. A.

2017-10-01

Shaped plasmas offer the possibility of manipulating laser pulses at intensities far above the damage limits for conventional optics. An example is the plasma channel, which is a cylindrical plasma column with an on-axis density minimum. Long plasma channels have been widely used to guide intense laser pulses, particularly in laser wakefield accelerators. A new concept, the ``plasma tornado'', offers the possibility of creating long plasma channels with no nearby structures and at densities lower than can be achieved by capillary discharges. A short plasma channel can focus a laser pulse in much the same manner as a conventional lens or off-axis parabola. When placed in front of the focal point of an intense laser pulse, a plasma channel lens (PCL) can reduce the effective f-number of conventional focusing optics. When placed beyond the focal point, it can act as a collimator. We will present experimental and modeling results for a new plasma tornado design, review experimental methods for generating short PCLs, and discuss potential applications. Supported by the Naval Research Laboratory Base Program.

Bifurcations: Focal Points of Particle Adhesion in Microvascular Networks

PubMed Central

Prabhakarpandian, Balabhaskar; Wang, Yi; Rea-Ramsey, Angela; Sundaram, Shivshankar; Kiani, Mohammad F.; Pant, Kapil

2011-01-01

Objective Particle adhesion in vivo is dependent on microcirculation environment which features unique anatomical (bifurcations, tortuosity, cross-sectional changes) and physiological (complex hemodynamics) characteristics. The mechanisms behind these complex phenomena are not well understood. In this study, we used a recently developed in vitro model of microvascular networks, called Synthetic Microvascular Network, for characterizing particle adhesion patterns in the microcirculation. Methods Synthetic microvascular networks were fabricated using soft lithography processes followed by particle adhesion studies using avidin and biotin-conjugated microspheres. Particle adhesion patterns were subsequently analyzed using CFD based modeling. Results Experimental and modeling studies highlighted the complex and heterogeneous fluid flow patterns encountered by particles in microvascular networks resulting in significantly higher propensity of adhesion (>1.5X) near bifurcations compared to the branches of the microvascular networks. Conclusion Bifurcations are the focal points of particle adhesion in microvascular networks. Changing flow patterns and morphology near bifurcations are the primary factors controlling the preferential adhesion of functionalized particles in microvascular networks. Synthetic microvascular networks provide an in vitro framework for understanding particle adhesion. PMID:21418388

Optical levitation of a non-spherical particle in a loosely focused Gaussian beam.

PubMed

Chang, Cheong Bong; Huang, Wei-Xi; Lee, Kyung Heon; Sung, Hyung Jin

2012-10-08

The optical force on a non-spherical particle subjected to a loosely focused laser beam was calculated using the dynamic ray tracing method. Ellipsoidal particles with different aspect ratios, inclination angles, and positions were modeled, and the effects of these parameters on the optical force were examined. The vertical component of the optical force parallel to the laser beam axis decreased as the aspect ratio decreased, whereas the ellipsoid with a small aspect ratio and a large inclination angle experienced a large vertical optical force. The ellipsoids were pulled toward or repelled away from the laser beam axis, depending on the inclination angle, and they experienced a torque near the focal point. The behavior of the ellipsoids in a viscous fluid was examined by analyzing a dynamic simulation based on the penalty immersed boundary method. As the ellipsoids levitated along the direction of the laser beam propagation, they moved horizontally with rotation. Except for the ellipsoid with a small aspect ratio and a zero inclination angle near the focal point, the ellipsoids rotated until the major axis aligned with the laser beam axis.

Thermal buffering of receivers for parabolic dish solar thermal power plants

NASA Technical Reports Server (NTRS)

Manvi, R.; Fujita, T.; Gajanana, B. C.; Marcus, C. J.

1980-01-01

A parabolic dish solar thermal power plant comprises a field of parabolic dish power modules where each module is composed of a two-axis tracking parabolic dish concentrator which reflects sunlight (insolation) into the aperture of a cavity receiver at the focal point of the dish. The heat generated by the solar flux entering the receiver is removed by a heat transfer fluid. In the dish power module, this heat is used to drive a small heat engine/generator assembly which is directly connected to the cavity receiver at the focal point. A computer analysis is performed to assess the thermal buffering characteristics of receivers containing sensible and latent heat thermal energy storage. Parametric variations of the thermal inertia of the integrated receiver-buffer storage systems coupled with different fluid flow rate control strategies are carried out to delineate the effect of buffer storage, the transient response of the receiver-storage systems and corresponding fluid outlet temperature. It is concluded that addition of phase change buffer storage will substantially improve system operational characteristics during periods of rapidly fluctuating insolation due to cloud passage.

Laser schlieren crystal monitor

NASA Technical Reports Server (NTRS)

Owen, Robert B. (Inventor); Johnston, Mary H. (Inventor)

1987-01-01

A system and method for monitoring the state of a crystal which is suspended in a solution is described which includes providing a light source for emitting a beam of light along an optical axis. A collimating lens is arranged along the optical axis for collimating the emitted beam to provide a first collimated light beam consisting of parallel light rays. By passing the first collimated light beam through a transparent container, a number of the parallel light rays are deflected off the surfaces of said crystal being monitored according to the refractive index gradient to provide a deflected beam of deflected light rays. A focusing lens is arranged along optical axis for focusing the deflected rays towards a desired focal point. A knife edge is arranged in a predetermined orientation at the focal point; and a screen is provided. A portion of the deflected beam is blocked with the knife edge to project only a portion of the deflected beam. A band is created at one edge of the image of the crystal which indicates the state of change of the surface of the crystal being monitored.

The parallel-sequential field subtraction techniques for nonlinear ultrasonic imaging

NASA Astrophysics Data System (ADS)

Cheng, Jingwei; Potter, Jack N.; Drinkwater, Bruce W.

2018-04-01

Nonlinear imaging techniques have recently emerged which have the potential to detect cracks at a much earlier stage and have sensitivity to particularly closed defects. This study utilizes two modes of focusing: parallel, in which the elements are fired together with a delay law, and sequential, in which elements are fired independently. In the parallel focusing, a high intensity ultrasonic beam is formed in the specimen at the focal point. However, in sequential focusing only low intensity signals from individual elements enter the sample and the full matrix of transmit-receive signals is recorded; with elastic assumptions, both parallel and sequential images are expected to be identical. Here we measure the difference between these images formed from the coherent component of the field and use this to characterize nonlinearity of closed fatigue cracks. In particular we monitor the reduction in amplitude at the fundamental frequency at each focal point and use this metric to form images of the spatial distribution of nonlinearity. The results suggest the subtracted image can suppress linear features (e.g., back wall or large scatters) and allow damage to be detected at an early stage.

Analysis of the geometric parameters of a solitary waves-based harvester to enhance its power output

NASA Astrophysics Data System (ADS)

Rizzo, Piervincenzo; Li, Kaiyuan

2017-07-01

We present a harvester formed by a metamaterial, an isotropic medium bonded to the metamaterial, and a wafer-type transducer glued to the medium. The harvester conveys the distributed energy of a mechanical oscillator into a focal point where this energy is converted into electricity. The metamaterial is made with an array of granular chains that host the propagation of highly nonlinear solitary waves triggered by the impact of the oscillator. At the interface between the chains and the isotropic solid, part of the acoustic energy refracts into the solid where it triggers the vibration of the solid and coalesces at a point. Here, the transducer converts the focalized stress wave and the waves generated by the reverberation with the edges into electric potential. The effects of the harvester’s geometric parameters on the amount of electrical power that can be harvested are quantified numerically. The results demonstrate that the power output of the harvester increases a few orders of magnitude when the appropriate geometric parameters are selected.

Determining noise temperatures in beam waveguide systems

NASA Technical Reports Server (NTRS)

Imbriale, W.; Veruttipong, W.; Otoshi, T.; Franco, M.

1994-01-01

A new 34-m research and development antenna was fabricated and tested as a precursor to introducing beam waveguide (BWG) antennas and Ka-band (32 GHz) frequencies into the NASA/JPL Deep Space Network. For deep space use, system noise temperature is a critical parameter. There are thought to be two major contributors to noise temperature in a BWG system: the spillover past the mirrors, and the conductivity loss in the walls. However, to date, there are no generally accepted methods for computing noise temperatures in a beam waveguide system. An extensive measurement program was undertaken to determine noise temperatures in such a system along with a correspondent effort in analytic prediction. Utilizing a very sensitive radiometer, noise temperature measurements were made at the Cassegrain focus, an intermediate focal point, and the focal point in the basement pedestal room. Several different horn diameters were used to simulate different amounts of spillover past the mirrors. Two analytic procedures were developed for computing noise temperature, one utilizing circular waveguide modes and the other a semiempirical approach. The results of both prediction methods are compared to the experimental data.

FAST in Space: Considerations for a Multibeam, Multipurpose Survey Using China's 500-m Aperture Spherical Radio Telescope (FAST)

NASA Astrophysics Data System (ADS)

Li, Di; Wang, Pei; Qian, Lei; Krco, Marko; Jiang, Peng; Yue, Youling; Jin, Chenjin; Zhu, Yan; Pan, Zhichen; Nan, Rendong; Dunning, Alex

2018-04-01

Having achieved "first light" immediately prior to the ceremony introducing it on 25 September 2016, China's 500-m aperture spherical radio telescope (FAST) is now being kept busy with commissions. Its innovative design requires 1,000 points to be measured and driven instead of just the two axes of motion, e.g., azimuth and elevation for most conventional antennas, to realize pointing and tracking. We have devised a survey plan to exploit the full sensitivity of FAST, while minimizing the complexities involved during system operation. The 19-beam L-band focal plan array will be rotated to specific angles and receive continuous data streams, while the surface shape and the focal cabin stay fixed. Such a survey will cover the northern sky in about 220 full days. Our aim is to obtain data simultaneously for pulsar search, detection of neutral hydrogen (HI) galaxies, HI imaging, and radio transients through multiple back ends. These data sets could represent a significant contribution to all related fields in radio astronomy and remain relevant for decades.

Hyperchromatic lens for recording time-resolved phenomena

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frayer, Daniel K.

A method and apparatus for the capture of a high number of quasi-continuous effective frames of 2-D data from an event at very short time scales (from less than 10.sup.-12 to more than 10.sup.-8 seconds) is disclosed which allows for short recording windows and effective number of frames. Active illumination, from a chirped laser pulse directed to the event creates a reflection where wavelength is dependent upon time and spatial position is utilized to encode temporal phenomena onto wavelength. A hyperchromatic lens system receives the reflection and maps wavelength onto axial position. An image capture device, such as holography ormore » plenoptic imaging device, captures the resultant focal stack from the hyperchromatic lens system in both spatial (imaging) and longitudinal (temporal) axes. The hyperchromatic lens system incorporates a combination of diffractive and refractive components to maximally separate focal position as a function of wavelength.« less

Broadband acoustic focusing by Airy-like beams based on acoustic metasurfaces

NASA Astrophysics Data System (ADS)

Chen, Di-Chao; Zhu, Xing-Feng; Wei, Qi; Wu, Da-Jian; Liu, Xiao-Jun

2018-01-01

An acoustic metasurface (AM) composed of space-coiling subunits is proposed to generate acoustic Airy-like beams (ALBs) by manipulating the transmitted acoustic phase. The self-accelerating, self-healing, and non-diffracting features of ALBs are demonstrated using finite element simulations. We further employ two symmetrical AMs to realize two symmetrical ALBs, resulting in highly efficient acoustic focusing. At the working frequency, the focal intensity can reach roughly 20 times that of the incident wave. It is found that the highly efficient acoustic focusing can circumvent obstacles in the propagating path and can be maintained in a broad frequency bandwidth. In addition, simply changing the separation between the two AMs can modulate the focal length of the proposed AM lens. ALBs generated by AMs and the corresponding AM lens may benefit applications in medical ultrasound imaging, biomedical therapy, and particle trapping and manipulation.

Membrane-less variable focus liquid lens with manual actuation

NASA Astrophysics Data System (ADS)

Patra, Roshan; Agarwal, Shivam; Kondaraju, Sasidhar; Bahga, Supreet Singh

2017-04-01

We present a tunable, membrane-less, mechanical-wetting liquid lens that can be actuated manually using a linear actuator such as screw or piston. The operation of the liquid lens is based on deforming the interface separating two immiscible liquids with different refractive indices, while pinning the three-phase contact line at the sharp edge of lens aperture. Our lens design improves upon the existing designs of mechanical-wetting lenses by eliminating the use of complex actuation mechanisms, without compromising on the optical performance. We demonstrate the operation of the liquid lens by tuning its power back and forth from negative to positive by simple rotation of a screw. We also present an analytical description of the focal length of the lens and validate it with detailed experimental measurements. Our experiments show that the focal length of the liquid lens can be tuned repeatably without any adverse effects of hysteresis and gravity.

Chromatic dispersion concentrator applied to photovoltaic systems

NASA Astrophysics Data System (ADS)

Sassi, G.

1980-01-01

The aim of this paper is to show how it is possible to realize a chromatic dispersion concentrator which collects the different monochromatic components of the solar spectrum separately in subsequently concentric rings in the focal zone. This comes about without an increase in the energetic losses compared to any other type of concentrator. If different photovoltaic elements with energy gaps equal to the photon energy falling on the focal zone are put in the latter, energy losses due to incomplete utilization of the solar spectrum and to incomplete utilization of the energy of a single photon can be drastically reduced. How the losses due to the voltage factor and the fill-factor of the photovoltaic elements of the system can be reduced compared to the normal silicon cells is also demonstrated. The other contributions to losses in the conversion process have only been mentioned, foreseeing their possible variation.

Telangiectatic focal nodular hyperplasia of the liver: a case detected at birth.

PubMed Central

Kim, Han-Seong; Kim, Young A.; Kim, Chong Jai; Suh, Yeon-Lim; Jang, Ja-June; Chi, Je G.

2003-01-01

A case of telangiectatic focal nodular hyperplasia (FNH) was detected at birth and was surgically removed. Grossly, the lesion was a solitary nodule and showed vague nodularity, appearing as an adenoma-like mass with fine fibrous septa, but having no macroscopic scar. On microscopic scale, the mass typically had neither fibrous central scar nor hyperplastic nodules different from the usual FNHs. The hepatic plates were separated by sinusoidal dilatation, sometimes alternating with areas of marked ectasia. Instead of large fibrous scar, thin fibrous septa were often found, and contained abnormal tortuous large arteries. These high-pressure vessels were connected directly into the adjacent sinusoids and made marked dilation of sinusoids. Bile ductular proliferation was also noted in the thin fibrous septa. To our knowledge, this is considered to be the first reported case of telangiectatic FNH detected at birth. PMID:14555832

Optical design of f-theta lens for dual wavelength selective laser melting

NASA Astrophysics Data System (ADS)

Feng, Lianhua; Cao, Hongzhong; Zhang, Ning; Xu, Xiping; Duan, Xuanming

2016-10-01

F-theta lens is an important unit for selective laser melting (SLM) manufacture. The dual wavelength f-theta lens has not been used in SLM manufacture. Here, we present the design of the f-theta lens which satisfies SLM manufacture with coaxial 532 nm and 1030 nm 1080 nm laser beams. It is composed of three pieces of spherical lenses. The focal spots for 532 nm laser and 1030 nm 1080 nm laser are smaller than 35 μm and 70 μm, respectively. The results meet the demands of high precision SLM. The chromatic aberration could cause separation between two laser focal spots in the scanning plane, so chromatic aberration correction is very important to our design. The lateral color of the designed f-theta lens is less than 11 μm within the scan area of 150 mm x 150 mm, which meet the application requirements of dual wavelength selective laser melting.

Evaluation of the LithoGold LG-380 Lithotripter: In Vitro Acoustic Characterization and Assessment of Renal Injury in the Pig Model

PubMed Central

Pishchalnikov, Yuri A.; Williams, James C.; Connors, Bret A.; Handa, Rajash K.; Lingeman, James E.; Evan, Andrew P.

2013-01-01

Abstract Purpose Conduct a laboratory evaluation of a novel low-pressure, broad focal zone electrohydraulic lithotripter (TRT LG-380). Methods Mapping of the acoustic field of the LG-380, along with a Dornier HM3, a Storz Modulith SLX, and a XiXin CS2012 (XX-ES) lithotripter was performed using a fiberoptic hydrophone. A pig model was used to assess renal response to 3000 shockwaves (SW) administered by a multistep power ramping protocol at 60 SW/min, and when animals were treated at the maximum power setting at 120 SW/min. Injury to the kidney was assessed by quantitation of lesion size and routine measures of renal function. Results SW amplitudes for the LG-380 ranged from (P+/P-) 7/-1.8 MPa at PL-1 to 21/-4 MPa at PL-11 while focal width measured ∼20 mm, wider than the HM3 (8 mm), SLX (2.6 mm), or XX-ES (18 mm). For the LG-380, there was gradual narrowing of the focal width to ∼10 mm after 5000 SWs, but this had negligible effect on breakage of model stones, because stones positioned at the periphery of the focal volume (10 mm off-axis) broke nearly as well as stones at the target point. Kidney injury measured less than 0.1% FRV (functional renal volume) for pigs treated using a gradual power ramping protocol at 60 SW/min and when SWs were delivered at maximum power at 120 SW/min. Conclusions The LG-380 exhibits the acoustic characteristics of a low-pressure, wide focal zone lithotripter and has the broadest focal width of any lithotripter yet reported. Although there was a gradual narrowing of focal width as the electrode aged, the efficiency of stone breakage was not affected. Because injury to the kidney was minimal when treatment followed either the recommended slow SW-rate multistep ramping protocol or when all SWs were delivered at fast SW-rate using maximum power, this appears to be a relatively safe lithotripter. PMID:23228113

Variable Magnification With Kirkpatrick-Baez Optics for Synchrotron X-Ray Microscopy

PubMed Central

Jach, Terrence; Bakulin, Alex S.; Durbin, Stephen M.; Pedulla, Joseph; Macrander, Albert

2006-01-01

We describe the distinction between the operation of a short focal length x-ray microscope forming a real image with a laboratory source (convergent illumination) and with a highly collimated intense beam from a synchrotron light source (Köhler illumination). We demonstrate the distinction with a Kirkpatrick-Baez microscope consisting of short focal length multilayer mirrors operating at an energy of 8 keV. In addition to realizing improvements in the resolution of the optics, the synchrotron radiation microscope is not limited to the usual single magnification at a fixed image plane. Higher magnification images are produced by projection in the limit of geometrical optics with a collimated beam. However, in distinction to the common method of placing the sample behind the optical source of a diverging beam, we describe the situation in which the sample is located in the collimated beam before the optical element. The ultimate limits of this magnification result from diffraction by the specimen and are determined by the sample position relative to the focal point of the optic. We present criteria by which the diffraction is minimized. PMID:27274930

Geometries and focal properties of two electron-lens systems useful in low-energy electron or ion scattering

NASA Technical Reports Server (NTRS)

Chutjian, A.

1979-01-01

Geometries and focal properties are given for two types of electron-lens system commonly needed in electron scattering. One is an electron gun that focuses electrons from a thermionic emitter onto a fixed point (target) over a wide range of final energies. The other is an electron analyzer system that focuses scattered electrons of variable energy onto a fixed position (e.g., the entrance plane of an analyzer) at fixed energy with a zero final beam angle. Analyzer-system focusing properties are given for superelastically, elastically, and inelastically scattered electrons. Computer calculations incorporating recent accurate tube-lens focal properties are used to compute lens voltages, locations and diameters of all pupils and windows, filling factors, and asymptotic rays throughout each lens system. Focus voltages as a function of electron energy and energy change are given, and limits of operation of each system discussed. Both lens systems have been in routine use for several years, and good agreement has been consistently found between calculated and operating lens voltages.

A fast processing route of aspheric polydimethylsiloxane lenses array (APLA) and optical characterization for smartphone microscopy

NASA Astrophysics Data System (ADS)

Fuh, Yiin-Kuen; Lai, Zheng-Hong

2017-02-01

A fast processing route of aspheric polydimethylsiloxane (PDMS) lenses array (APLA) is proposed via the combined effect of inverted gravitational and heat-assisted forces. The fabrication time can be dramatically reduced to 30 s, compared favorably to the traditional duration of 2 hours of repeated cycles of addition-curing processes. In this paper, a low-cost flexible lens can be fabricated by repeatedly depositing, inverting, curing a hanging transparent PDMS elastomer droplet on a previously deposited curved structure. Complex structures with aspheric curve features and various focal lengths can be successfully produced and the fabricated 4 types of APLA have various focal lengths in the range of 7.03 mm, 6.00 mm, 5.33 mm, and 4.43 mm, respectively. Empirically, a direct relationship between the PDMS volume and focal lengths of the lenses can be experimentally deducted. Using these fabricated APLA, an ordinary commercial smartphone camera can be easily transformed to a low-cost, portable digital microscopy (50×magnification) such that point of care diagnostic can be implemented pervasively.

Photoacoustic and ultrasound imaging of cancellous bone tissue.

PubMed

Yang, Lifeng; Lashkari, Bahman; Tan, Joel W Y; Mandelis, Andreas

2015-07-01

We used ultrasound (US) and photoacoustic (PA) imaging modalities to characterize cattle trabecular bones. The PA signals were generated with an 805-nm continuous wave laser used for optimally deep optical penetration depth. The detector for both modalities was a 2.25-MHz US transducer with a lateral resolution of ~1 mm at its focal point. Using a lateral pixel size much larger than the size of the trabeculae, raster scanning generated PA images related to the averaged values of the optical and thermoelastic properties, as well as density measurements in the focal volume. US backscatter yielded images related to mechanical properties and density in the focal volume. The depth of interest was selected by time-gating the signals for both modalities. The raster scanned PA and US images were compared with microcomputed tomography (μCT) images averaged over the same volume to generate similar spatial resolution as US and PA. The comparison revealed correlations between PA and US modalities with the mineral volume fraction of the bone tissue. Various features and properties of these modalities such as detectable depth, resolution, and sensitivity are discussed.

Multiple Spatial Frequencies Pyramid WaveFront Sensing

NASA Astrophysics Data System (ADS)

Ragazzoni, Roberto; Vassallo, Daniele; Dima, Marco; Portaluri, Elisa; Bergomi, Maria; Greggio, Davide; Viotto, Valentina; Gullieuszik, Marco; Biondi, Federico; Carolo, Elena; Chinellato, Simonetta; Farinato, Jacopo; Magrin, Demetrio; Marafatto, Luca

2017-11-01

A modification of the pyramid wavefront sensor is described. In this conceptually new class of devices, the perturbations are split at the level of the focal plane depending upon their spatial frequencies, and then measured separately. The aim of this approach is to increase the accuracy in the determination of some range of spatial frequency perturbations, or a certain classes of modes, disentangling them from the noise associated to the Poissonian fluctuations of the light coming from the perturbations outside of the range of interest or from the background in the pupil planes; the latter case specifically when the pyramid wavefront sensor is used with a large modulation. While the limits and the effectiveness of this approach should be further investigated, a number of variations on the concept are shown, including a generalization of the spatial filtering in the point-diffraction wavefront sensor. The simplest application, a generalization to the pyramid of the well-known spatially filtering in wavefront sensing, is showing promise as a significant limiting magnitude advance. Applications are further speculated in the area of extreme adaptive optics and when serving spectroscopic instrumentation where “light in the bucket” rather than Strehl performance is required.