Sample records for serf creation date

  1. SALT-RESPONSIVE ERF1 is a negative regulator of grain filling and gibberellin-mediated seedling establishment in rice.

    PubMed

    Schmidt, Romy; Schippers, Jos H M; Mieulet, Delphine; Watanabe, Mutsumi; Hoefgen, Rainer; Guiderdoni, Emmanuel; Mueller-Roeber, Bernd

    2014-02-01

    Grain quality is an important agricultural trait that is mainly determined by grain size and composition. Here, we characterize the role of the rice transcription factor (TF) SALT-RESPONSIVE ERF1 (SERF1) during grain development. Through genome-wide expression profiling and chromatin immunoprecipitation, we found that SERF1 directly regulates RICE PROLAMIN-BOX BINDING FACTOR (RPBF), a TF that functions as a positive regulator of grain filling. Loss of SERF1 enhances RPBF expression resulting in larger grains with increased starch content, while SERF1 overexpression represses RPBF resulting in smaller grains. Consistently, during grain filling, starch biosynthesis genes such as GRANULE-BOUND STARCH SYNTHASEI (GBSSI), STARCH SYNTHASEI (SSI), SSIIIa, and ADP-GLUCOSE PYROPHOSPHORYLASE LARGE SUBUNIT2 (AGPL2) are up-regulated in SERF1 knockout grains. Moreover, SERF1 is a direct upstream regulator of GBSSI. In addition, SERF1 negatively regulates germination by controlling RPBF expression, which mediates the gibberellic acid (GA)-induced expression of RICE AMYLASE1A (RAmy1A). Loss of SERF1 results in more rapid seedling establishment, while SERF1 overexpression has the opposite effect. Our study reveals that SERF1 represents a negative regulator of grain filling and seedling establishment by timing the expression of RPBF.

  2. SALT-RESPONSIVE ERF1 Regulates Reactive Oxygen Species–Dependent Signaling during the Initial Response to Salt Stress in Rice[W

    PubMed Central

    Schmidt, Romy; Mieulet, Delphine; Hubberten, Hans-Michael; Obata, Toshihiro; Hoefgen, Rainer; Fernie, Alisdair R.; Fisahn, Joachim; San Segundo, Blanca; Guiderdoni, Emmanuel; Schippers, Jos H.M.; Mueller-Roeber, Bernd

    2013-01-01

    Early detection of salt stress is vital for plant survival and growth. Still, the molecular processes controlling early salt stress perception and signaling are not fully understood. Here, we identified SALT-RESPONSIVE ERF1 (SERF1), a rice (Oryza sativa) transcription factor (TF) gene that shows a root-specific induction upon salt and hydrogen peroxide (H2O2) treatment. Loss of SERF1 impairs the salt-inducible expression of genes encoding members of a mitogen-activated protein kinase (MAPK) cascade and salt tolerance–mediating TFs. Furthermore, we show that SERF1-dependent genes are H2O2 responsive and demonstrate that SERF1 binds to the promoters of MAPK KINASE KINASE6 (MAP3K6), MAPK5, DEHYDRATION-RESPONSIVE ELEMENT BINDING2A (DREB2A), and ZINC FINGER PROTEIN179 (ZFP179) in vitro and in vivo. SERF1 also directly induces its own gene expression. In addition, SERF1 is a phosphorylation target of MAPK5, resulting in enhanced transcriptional activity of SERF1 toward its direct target genes. In agreement, plants deficient for SERF1 are more sensitive to salt stress compared with the wild type, while constitutive overexpression of SERF1 improves salinity tolerance. We propose that SERF1 amplifies the reactive oxygen species–activated MAPK cascade signal during the initial phase of salt stress and translates the salt-induced signal into an appropriate expressional response resulting in salt tolerance. PMID:23800963

  3. GET-SERF, a new gradient encoded SERF experiment for the trivial edition of 1H-19F couplings

    NASA Astrophysics Data System (ADS)

    Di Pietro, Maria Enrica; Aroulanda, Christie; Merlet, Denis

    2013-09-01

    A new spatially encoded heteronuclear 1H-19F selective refocusing NMR experiment (GET-SERF) is proposed. This sequence allows editing in one single 2D experiment all couplings between a selected fluorine site and all the proton nuclei of the molecule. Its efficiency is illustrated in the case of diflunisal, a difluorinated anti-inflammatory drug, in isotropic and anisotropic media.

  4. Estimation of contraction scour in riverbed using SERF

    USGS Publications Warehouse

    Jiang, J.; Ganju, N.K.; Mehta, A.J.

    2004-01-01

    Contraction scour in a firm-clay estuarine riverbed is estimated at an oil-unloading terminal at the Port of Haldia in India, where a scour hole attained a maximum depth greater than 5 m relative to the original bottom. A linear equation for the erosion flux as a function of the excess bed shear stress was semicalibrated in a rotating-cylinder device called SERF (Simulator of Erosion Rate Function) and coupled to a hydrodynamic code to simulate the hole as a clear-water scour process. SERF, whose essential design is based on previous such devices, additionally included a load cell for in situ and rapid measurement of the eroded sediment mass. Based on SERF's performance and the degree of comparison between measured and simulated hole geometry, it appears that this device holds promise as a simple tool for prediction of scour in firm-clay beds. ?? ASCE.

  5. Application of spin-exchange relaxation-free magnetometry to the Cosmic Axion Spin Precession Experiment

    NASA Astrophysics Data System (ADS)

    Wang, Tao; Kimball, Derek F. Jackson; Sushkov, Alexander O.; Aybas, Deniz; Blanchard, John W.; Centers, Gary; Kelley, Sean R. O.'; Wickenbrock, Arne; Fang, Jiancheng; Budker, Dmitry

    2018-03-01

    The Cosmic Axion Spin Precession Experiment (CASPEr) seeks to measure oscillating torques on nuclear spins caused by axion or axion-like-particle (ALP) dark matter via nuclear magnetic resonance (NMR) techniques. A sample spin-polarized along a leading magnetic field experiences a resonance when the Larmor frequency matches the axion/ALP Compton frequency, generating precessing transverse nuclear magnetization. Here we demonstrate a Spin-Exchange Relaxation-Free (SERF) magnetometer with sensitivity ≈ 1 fT /√{ Hz } and an effective sensing volume of 0.1 cm3 that may be useful for NMR detection in CASPEr. A potential drawback of SERF-magnetometer-based NMR detection is the SERF's limited dynamic range. Use of a magnetic flux transformer to suppress the leading magnetic field is considered as a potential method to expand the SERF's dynamic range in order to probe higher axion/ALP Compton frequencies.

  6. Investigation of erosion rates of field samples using FDOT's enhanced sediment erosion rate flume (SERF).

    DOT National Transportation Integrated Search

    2013-09-01

    The first part of this project was to enhance and improve the Florida Department of Transportations : Sediment Erosion Rate Flume (SERF) device. Notable improvements include a pump repair, laser : system enhancement, installation of a digital vide...

  7. Economic Risk Analysis of Agricultural Tillage Systems Using the SMART Stochastic Efficiency Software Package

    USDA-ARS?s Scientific Manuscript database

    Recently, a variant of stochastic dominance called stochastic efficiency with respect to a function (SERF) has been developed and applied. Unlike traditional stochastic dominance approaches, SERF uses the concept of certainty equivalents (CEs) to rank a set of risk-efficient alternatives instead of...

  8. Facilities | Photovoltaic Research | NREL

    Science.gov Websites

    Centers (RTCs) The Department of Energy Regional Test Centers for solar technologies serve to validate PV development to provide foundational support for the photovoltaic (PV) industry and PV users. Photo of the Solar Research Energy Facility. Solar Energy Research Facility (SERF) The SERF houses various

  9. Pushing the limits of signal resolution to make coupling measurement easier.

    PubMed

    Herbert Pucheta, José Enrique; Pitoux, Daisy; Grison, Claire M; Robin, Sylvie; Merlet, Denis; Aitken, David J; Giraud, Nicolas; Farjon, Jonathan

    2015-05-07

    Probing scalar couplings are essential for structural elucidation in molecular (bio)chemistry. While the measurement of JHH couplings is facilitated by SERF experiments, overcrowded signals represent a significant limitation. Here, a new band selective pure shift SERF allows access to δ(1)H and JHH with an ultrahigh spectral resolution.

  10. Students To Race Solar-Powered Vehicles

    Science.gov Websites

    12 inches high. The 20-meter race is a double elimination competition with awards going to the five fastest cars. Five design awards also will be given based on technology, craftsmanship and innovation. The Solar Energy Research Facility (SERF). The event is open to the public. To reach the SERF, take

  11. In situ triaxial magnetic field compensation for the spin-exchange-relaxation-free atomic magnetometer.

    PubMed

    Fang, Jiancheng; Qin, Jie

    2012-10-01

    The spin-exchange-relaxation-free (SERF) atomic magnetometer is an ultra-high sensitivity magnetometer, but it must be operated in a magnetic field with strength less than about 10 nT. Magnetic field compensation is an effective way to shield the magnetic field, and this paper demonstrates an in situ triaxial magnetic field compensation system for operating the SERF atomic magnetometer. The proposed hardware is based on optical pumping, which uses some part of the SERF atomic magnetometer itself, and the compensation method is implemented by analyzing the dynamics of the atomic spin. The experimental setup for this compensation system is described, and with this configuration, a residual magnetic field of strength less than 2 nT (±0.38 nT in the x axis, ±0.43 nT in the y axis, and ±1.62 nT in the z axis) has been achieved after compensation. The SERF atomic magnetometer was then used to verify that the residual triaxial magnetic fields were coincident with what were achieved by the compensation system.

  12. The polarization and the fundamental sensitivity of 39K (133Cs)-85Rb-4He hybrid optical pumping spin exchange relaxation free atomic magnetometers.

    PubMed

    Liu, Jian-Hua; Jing, Dong-Yang; Wang, Liang-Liang; Li, Yang; Quan, Wei; Fang, Jian-Cheng; Liu, Wu-Ming

    2017-07-28

    The hybrid optical pumping spin exchange relaxation free (SERF) atomic magnetometers can realize ultrahigh sensitivity measurement of magnetic field and inertia. We have studied the 85 Rb polarization of two types of hybrid optical pumping SERF magnetometers based on 39 K- 85 Rb- 4 He and 133 Cs- 85 Rb- 4 He respectively. Then we found that 85 Rb polarization varies with the number density of buffer gas 4 He and quench gas N 2 , pumping rate of pump beam and cell temperature respectively, which will provide an experimental guide for the design of the magnetometer. We obtain a general formula on the fundamental sensitivity of the hybrid optical pumping SERF magnetometer due to shot-noise. The formula describes that the fundamental sensitivity of the magnetometer varies with the number density of buffer gas and quench gas, the pumping rate of pump beam, external magnetic field, cell effective radius, measurement volume, cell temperature and measurement time. We obtain a highest fundamental sensitivity of 1.5073 aT/Hz 1/2 (1 aT = 10 -18 T) with 39 K- 85 Rb- 4 He magnetometer between above two types of magnetometers when 85 Rb polarization is 0.1116. We estimate the fundamental sensitivity limit of the hybrid optical pumping SERF magnetometer to be superior to 1.8359 × 10 -2 aT/Hz 1/2 , which is higher than the shot-noise-limited sensitivity of 1 aT/Hz 1/2 of K SERF atomic magnetometer.

  13. Search for exotic spin-dependent interactions with a spin-exchange relaxation-free magnetometer

    DOE PAGES

    Chu, Pinghan; Kim, Young Jin; Savukov, Igor Mykhaylovich

    2016-08-15

    We propose a novel experimental approach to explore exotic spin-dependent interactions using a spin-exchange relaxation-free (SERF) magnetometer, the most sensitive noncryogenic magnetic-field sensor. This approach studies the interactions between optically polarized electron spins located inside a vapor cell of the SERF magnetometer and unpolarized or polarized particles of external solid-state objects. The coupling of spin-dependent interactions to the polarized electron spins of the magnetometer induces the tilt of the electron spins, which can be detected with high sensitivity by a probe laser beam similarly as an external magnetic field. Lastly, we estimate that by moving unpolarized or polarized objects nextmore » to the SERF Rb vapor cell, the experimental limit to the spin-dependent interactions can be significantly improved over existing experiments, and new limits on the coupling strengths can be set in the interaction range below 10 –2 m.« less

  14. Saving Water at Los Alamos National Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Erickson, Andy

    Los Alamos National Laboratory decreased its water usage by 26 percent in 2014, with about one-third of the reduction attributable to using reclaimed water to cool a supercomputing center. The Laboratory's goal during 2014 was to use only re-purposed water to support the mission at the Strategic Computing Complex. Using reclaimed water from the Sanitary Effluent Reclamation Facility, or SERF, substantially decreased water usage and supported the overall mission. SERF collects industrial wastewater and treats it for reuse. The reclamation facility contributed more than 27 million gallons of re-purposed water to the Laboratory's computing center, a secured supercomputing facility thatmore » supports the Laboratory’s national security mission and is one of the institution’s larger water users. In addition to the strategic water reuse program at SERF, the Laboratory reduced water use in 2014 by focusing conservation efforts on areas that use the most water, upgrading to water-conserving fixtures, and repairing leaks identified in a biennial survey.« less

  15. Saving Water at Los Alamos National Laboratory

    ScienceCinema

    Erickson, Andy

    2018-01-16

    Los Alamos National Laboratory decreased its water usage by 26 percent in 2014, with about one-third of the reduction attributable to using reclaimed water to cool a supercomputing center. The Laboratory's goal during 2014 was to use only re-purposed water to support the mission at the Strategic Computing Complex. Using reclaimed water from the Sanitary Effluent Reclamation Facility, or SERF, substantially decreased water usage and supported the overall mission. SERF collects industrial wastewater and treats it for reuse. The reclamation facility contributed more than 27 million gallons of re-purposed water to the Laboratory's computing center, a secured supercomputing facility that supports the Laboratory’s national security mission and is one of the institution’s larger water users. In addition to the strategic water reuse program at SERF, the Laboratory reduced water use in 2014 by focusing conservation efforts on areas that use the most water, upgrading to water-conserving fixtures, and repairing leaks identified in a biennial survey.

  16. Field optimization method of a dual-axis atomic magnetometer based on frequency-response and dynamics

    NASA Astrophysics Data System (ADS)

    Xing, Li; Quan, Wei; Fan, Wenfeng; Li, Rujie; Jiang, Liwei; Fang, Jiancheng

    2018-05-01

    The frequency-response and dynamics of a dual-axis spin-exchange-relaxation-free (SERF) atomic magnetometer are investigated by means of transfer function analysis. The frequency-response at different bias magnetic fields is tested to demonstrate the effect of the residual magnetic field. The resonance frequency of alkali atoms and magnetic linewidth can be obtained simultaneously through our theoretical model. The coefficient of determination of the fitting results is superior to 0.995 with 95% confidence bounds. Additionally, step responses are applied to analyze the dynamics of the control system and the effect of imperfections. Finally, a noise-limited magnetic field resolution of 15 fT {{\\sqrt{Hz}}-1} has been achieved for our dual-axis SERF atomic magnetometer through magnetic field optimization.

  17. 49 CFR 1150.32 - Procedures and relevant dates-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Procedures and relevant dates-transactions that involve creation of Class III carriers. 1150.32 Section 1150.32 Transportation Other Regulations Relating.... 10901 § 1150.32 Procedures and relevant dates—transactions that involve creation of Class III carriers...

  18. 49 CFR 1150.32 - Procedures and relevant dates-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Procedures and relevant dates-transactions that involve creation of Class III carriers. 1150.32 Section 1150.32 Transportation Other Regulations Relating.... 10901 § 1150.32 Procedures and relevant dates—transactions that involve creation of Class III carriers...

  19. 49 CFR 1150.32 - Procedures and relevant dates-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Procedures and relevant dates-transactions that involve creation of Class III carriers. 1150.32 Section 1150.32 Transportation Other Regulations Relating.... 10901 § 1150.32 Procedures and relevant dates—transactions that involve creation of Class III carriers...

  20. 49 CFR 1150.32 - Procedures and relevant dates-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Procedures and relevant dates-transactions that involve creation of Class III carriers. 1150.32 Section 1150.32 Transportation Other Regulations Relating.... 10901 § 1150.32 Procedures and relevant dates—transactions that involve creation of Class III carriers...

  1. 26 CFR 26.2601-1 - Effective dates.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... effect only on the expiration of a stated period, whether or not on or before September 25, 1985, notice... period, measured from the date of creation of the trust, extending beyond any life in being at the date of creation of the trust plus a period of 21 years plus, if necessary, a reasonable period of...

  2. 49 CFR 1150.45 - Procedures and relevant dates-transactions under section 10902 that involve creation of Class I...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Procedures and relevant dates-transactions under section 10902 that involve creation of Class I or Class II rail carriers. 1150.45 Section 1150.45... dates—transactions under section 10902 that involve creation of Class I or Class II rail carriers. (a...

  3. 49 CFR 1150.35 - Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers. 1150.35 Section 1150.35 Transportation Other Regulations.... 10901 § 1150.35 Procedures and relevant dates—transactions that involve creation of Class I or Class II...

  4. 49 CFR 1150.45 - Procedures and relevant dates-transactions under section 10902 that involve creation of Class I...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Procedures and relevant dates-transactions under section 10902 that involve creation of Class I or Class II rail carriers. 1150.45 Section 1150.45... dates—transactions under section 10902 that involve creation of Class I or Class II rail carriers. (a...

  5. 49 CFR 1150.35 - Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers. 1150.35 Section 1150.35 Transportation Other Regulations.... 10901 § 1150.35 Procedures and relevant dates—transactions that involve creation of Class I or Class II...

  6. 49 CFR 1150.35 - Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers. 1150.35 Section 1150.35 Transportation Other Regulations.... 10901 § 1150.35 Procedures and relevant dates—transactions that involve creation of Class I or Class II...

  7. 49 CFR 1150.45 - Procedures and relevant dates-transactions under section 10902 that involve creation of Class I...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Procedures and relevant dates-transactions under section 10902 that involve creation of Class I or Class II rail carriers. 1150.45 Section 1150.45... dates—transactions under section 10902 that involve creation of Class I or Class II rail carriers. (a...

  8. 49 CFR 1150.35 - Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers. 1150.35 Section 1150.35 Transportation Other Regulations.... 10901 § 1150.35 Procedures and relevant dates—transactions that involve creation of Class I or Class II...

  9. 49 CFR 1150.45 - Procedures and relevant dates-transactions under section 10902 that involve creation of Class I...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Procedures and relevant dates-transactions under section 10902 that involve creation of Class I or Class II rail carriers. 1150.45 Section 1150.45... dates—transactions under section 10902 that involve creation of Class I or Class II rail carriers. (a...

  10. 49 CFR 1150.45 - Procedures and relevant dates-transactions under section 10902 that involve creation of Class I...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Procedures and relevant dates-transactions under section 10902 that involve creation of Class I or Class II rail carriers. 1150.45 Section 1150.45... dates—transactions under section 10902 that involve creation of Class I or Class II rail carriers. (a...

  11. 49 CFR 1150.35 - Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Procedures and relevant dates-transactions that involve creation of Class I or Class II carriers. 1150.35 Section 1150.35 Transportation Other Regulations.... 10901 § 1150.35 Procedures and relevant dates—transactions that involve creation of Class I or Class II...

  12. A fast determination method for transverse relaxation of spin-exchange-relaxation-free magnetometer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, Jixi, E-mail: lujixi@buaa.edu.cn; Qian, Zheng; Fang, Jiancheng

    2015-04-15

    We propose a fast and accurate determination method for transverse relaxation of the spin-exchange-relaxation-free (SERF) magnetometer. This method is based on the measurement of magnetic resonance linewidth via a chirped magnetic field excitation and the amplitude spectrum analysis. Compared with the frequency sweeping via separate sinusoidal excitation, our method can realize linewidth determination within only few seconds and meanwhile obtain good frequency resolution. Therefore, it can avoid the drift error in long term measurement and improve the accuracy of the determination. As the magnetic resonance frequency of the SERF magnetometer is very low, we include the effect of the negativemore » resonance frequency caused by the chirp and achieve the coefficient of determination of the fitting results better than 0.998 with 95% confidence bounds to the theoretical equation. The experimental results are in good agreement with our theoretical analysis.« less

  13. Highlights of the study of energy release in flares

    NASA Technical Reports Server (NTRS)

    Rust, D. M.; Batchelor, D. A.

    1987-01-01

    From February 26 to March 1, 1979, 32 solar flare investigators attended a workshop at Cambridge, MA to define objectives and devise a scientific program for the study of energy release in flares (SERF) during the coming solar maximum. Herein, some major results of the ensuing five-year effort to observe and understand the flare energy release process and its effects (energetic particle production, coronal and chromospheric heating, electromagnetic radiations, and mass motions and ejections) are reviewed. The central issue - what processes store and release the energy liberated in flares - remains unresolved except in the most general terms (e.g., it is generally agreed that the energy is stored in sheared or stressed magnetic fields and released by field annihilation during some MHD instability). Resolving that issue is still one of the most important goals in solar physics, but the advances during the SERF program have brought it closer.

  14. Preventing the forgotten ureteral stent: implementation of a web-based stent registry with automatic recall application.

    PubMed

    Lynch, Mark F; Ghani, Khurshid R; Frost, Ian; Anson, Ken M

    2007-09-01

    To describe and analyze a unique computerized system that tracks ureteral stents and automatically sends a notice by e-mail to clinical staff if a stent becomes overdue for removal. We have developed an electronic stent register (ESR) and stent extraction reminder facility (SERF) located within our hospital computer network. After stent insertion, a stent "episode" is created in the ESR with a mandatory maximal stent life (MSL). The SERF interrogates the ESR on a daily basis and identifies stents that have breached its MSL, generating daily e-mail notices to personnel until the stent is removed and the ESR updated. The episode data capture initially employing manual entry was changed to barcode technology acquisition. We analyzed the success of patient recall and conducted a prospective, blinded review to determine the success of the data acquisition. A total of 293 episodes were created within 2.4 years. Of the 241 (86%) episodes that were closed, 123 (51%) went beyond the MSL. The mean delay from designated MSL to stent removal was 20.89 days (SD 19.71). In the 7 months before barcode data acquisition, 43 of 71 stents were entered into the ESR (data capture rate 61%). In the 7 months after barcode data acquisition, 52 of 60 stents were entered (data capture rate 87%; P = 0.0009). The results of our study have shown the ESR and SERF to be robust and valuable tools for the treatment of patients with ureteral stents. Barcode acquisition significantly improved the stent insertion capture rate. This system ensures improved patient safety with an element of protection from potential litigation.

  15. Genome-scale investigation of phenotypically distinct but nearly clonal Trichoderma strains

    PubMed Central

    Weld, Richard J.; Cox, Murray P.; Bradshaw, Rosie E.; McLean, Kirstin L.; Stewart, Alison; Steyaert, Johanna M.

    2016-01-01

    Biological control agents (BCA) are beneficial organisms that are applied to protect plants from pests. Many fungi of the genus Trichoderma are successful BCAs but the underlying mechanisms are not yet fully understood. Trichoderma cf. atroviride strain LU132 is a remarkably effective BCA compared to T. cf. atroviride strain LU140 but these strains were found to be highly similar at the DNA sequence level. This unusual combination of phenotypic variability and high DNA sequence similarity between separately isolated strains prompted us to undertake a genome comparison study in order to identify DNA polymorphisms. We further investigated if the polymorphisms had functional effects on the phenotypes. The two strains were clearly identified as individuals, exhibiting different growth rates, conidiation and metabolism. Superior pathogen control demonstrated by LU132 depended on its faster growth, which is a prerequisite for successful distribution and competition. Genome sequencing identified only one non-synonymous single nucleotide polymorphism (SNP) between the strains. Based on this SNP, we successfully designed and validated an RFLP protocol that can be used to differentiate LU132 from LU140 and other Trichoderma strains. This SNP changed the amino acid sequence of SERF, encoded by the previously undescribed single copy gene “small EDRK-rich factor” (serf). A deletion of serf in the two strains did not lead to identical phenotypes, suggesting that, in addition to the single functional SNP between the nearly clonal Trichoderma cf. atroviride strains, other non-genomic factors contribute to their phenotypic variation. This finding is significant as it shows that genomics is an extremely useful but not exhaustive tool for the study of biocontrol complexity and for strain typing. PMID:27190719

  16. Investigation of erosion rates of field samples using FDOT's enhanced sediment erosion rate flume (SERF) : [summary].

    DOT National Transportation Integrated Search

    2013-09-01

    The most common cause of bridge failure in : the United States is the scouring of sediments, : which are broadly classified as cohesionless : (sand and gravel) and cohesive (rock, clay, sandclay mixtures). For cohesionless sediments, : predicting sco...

  17. Microfabricated spin exchange relaxation free atomic magnetometer

    NASA Astrophysics Data System (ADS)

    Griffith, W. Clark; Jimenez-Martinez, Ricardo; Preusser, Jan; Knappe, Svenja; Kitching, John

    2009-05-01

    Methods first developed at NIST for MEMS-based atomic clocks have been applied to magnetic field sensors. The sensors are built around microfabricated alkali-atom vapor cells integrated with micro-optics and a VCSEL light source. Exceptional magnetic field sensitivities can be achieved in a small volume vapor cell, especially when operated in the spin-exchange relaxation free (SERF) regime. In this technique, magnetic resonance broadening due to spin-exchange collisions is suppressed under conditions of high alkali density and low magnetic fields. We have demonstrated sensitivities better than 100 fT/Hz^1/2 with a millimeter scale SERF sensor.ootnotetextV. Shah, S. Knappe, P.D.D. Schwindt, and J. Kitching, Nature Photonics, 1, 649 (2007). Adding flux concentratorsootnotetextW.C. Griffith, R. Jimenez-Martinez, V. Shah, S. Knappe, and J. Kitching, Appl. Phys. Lett., 94, 023502 (2009). around the vapor cell further improves the sensitivity to 10 fT/Hz^1/2, potentially providing a low power, noncryogenic alternative to SQUID sensors.

  18. USSR Report, Cybernetics, Computers and Automation Technology

    DTIC Science & Technology

    1985-08-27

    ions penetrate the semiconductor’s lattice and change its electrical properties at the penetration sites. Electron/ion facilities consisting of...Design Systems], AVTOMETRIYA, 1984, No 4. 56 k. -^ qCD (l[^]^[Bm]-*{MCp^ ■srn ,(4) :2) (2(&L_ -Serf Key: 1. Application program 3. Link module

  19. Work with Us | Photovoltaic Research | NREL

    Science.gov Websites

    Research Facility (SERF) Science and Technology Facility (S&TF) Outdoor Test Facility (OTF) Energy the Hands On Photovoltaic Experience (HOPE). Photo of a researcher in a lab Photovoltaic research and related activities occur in various locations across the NREL campus, including the Solar Energy Research

  20. Students to Race Solar-Powered Model Cars

    Science.gov Websites

    hotel and the NREL Visitors Center. The SERF is the silver-colored building one-eighth mile past the teams Eagle Valley Middle School Two teams Fountain Middle School One team Hayden Middle School Two teams Kunsmiller Middle School One team Little Elementary Two teams Lyons Middle School Two teams Maple

  1. Continuum of risk analysis methods to assess tillage system sustainability at the experimental plot level

    USDA-ARS?s Scientific Manuscript database

    The primary goal of this study was to evaluate the efficacy of stochastic dominance and stochastic efficiency with respect to a function (SERF) methodology for ranking conventional and conservation tillage systems using 14 years (1990-2003) of economic budget data collected from 36 plots at the Iowa...

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Karaulanov, Todor; Savukov, Igor; Kim, Young Jin

    We constructed a spin-exchange relaxation-free (SERF) magnetometer with a small angle between the pump and probe beams facilitating a multi-channel design with a flat pancake cell. This configuration provides almost complete overlap of the beams in the cell, and prevents the pump beam from entering the probe detection channel. By coupling the lasers in multi-mode fibers, without an optical isolator or field modulation, we demonstrate a sensitivity of 10 fTmore » $$/\\sqrt{\\text{Hz}}$$ for frequencies between 10 Hz and 100 Hz. In addition to the experimental study of sensitivity, we present a theoretical analysis of SERF magnetometer response to magnetic fields for small-angle and parallel-beam configurations, and show that at optimal DC offset fields the magnetometer response is comparable to that in the orthogonal-beam configuration. Based on the analysis, we also derive fundamental and probe-limited sensitivities for the arbitrary non-orthogonal geometry. The expected practical and fundamental sensitivities are of the same order as those in the orthogonal geometry. As a result, we anticipate that our design will be useful for magnetoencephalography (MEG) and magnetocardiography (MCG) applications.« less

  3. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Young Jin

    The PowerPoint presentation focused on research goals, specific information about the atomic magnetometer, response and resolution factors of the SERF magnetometer, FC+AM systems, tests of field transfer and resolution on FC, gradient cancellation, testing of AM performance, ideas for a multi-channel AM, including preliminary sensitivity testing, and a description of a 6 channel DAQ system. A few ideas for future work ended the presentation.

  4. U.S. EPA, Pesticide Product Label, DIAZINON AG 500 EMULSIFIABLE CONCENTRATE, 01/29/1975

    EPA Pesticide Factsheets

    2011-04-21

    ... II aflp "t!:'\\: o! DIH/lllll/! A(i:lUO ,I'Op~ ;1 .... a ~pra~· III ,I 1I .. 1Il!!lurn 01 .! ~8b 01 water Pt:1 serf' o! 10 ~.Il .... ,I! \\\\,I't'r pt'r h,lt· It'l ).':oul!d appl1('stIOll:-'. ...

  5. 24 CFR 203.257 - Creation of the contract.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Creation of the contract. 203.257 Section 203.257 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 203.257 Creation of the contract. The mortgage shall be an insured mortgage from the date of the...

  6. 24 CFR 203.257 - Creation of the contract.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Creation of the contract. 203.257 Section 203.257 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 203.257 Creation of the contract. The mortgage shall be an insured mortgage from the date of the...

  7. 24 CFR 203.257 - Creation of the contract.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Creation of the contract. 203.257 Section 203.257 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 203.257 Creation of the contract. The mortgage shall be an insured mortgage from the date of the...

  8. 24 CFR 203.257 - Creation of the contract.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Creation of the contract. 203.257 Section 203.257 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 203.257 Creation of the contract. The mortgage shall be an insured mortgage from the date of the...

  9. 24 CFR 203.257 - Creation of the contract.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Creation of the contract. 203.257 Section 203.257 Housing and Urban Development Regulations Relating to Housing and Urban Development... § 203.257 Creation of the contract. The mortgage shall be an insured mortgage from the date of the...

  10. Suppression of vapor cell temperature error for spin-exchange-relaxation-free magnetometer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lu, Jixi, E-mail: lujixi@buaa.edu.cn; Qian, Zheng; Fang, Jiancheng

    2015-08-15

    This paper presents a method to reduce the vapor cell temperature error of the spin-exchange-relaxation-free (SERF) magnetometer. The fluctuation of cell temperature can induce variations of the optical rotation angle, resulting in a scale factor error of the SERF magnetometer. In order to suppress this error, we employ the variation of the probe beam absorption to offset the variation of the optical rotation angle. The theoretical discussion of our method indicates that the scale factor error introduced by the fluctuation of the cell temperature could be suppressed by setting the optical depth close to one. In our experiment, we adjustmore » the probe frequency to obtain various optical depths and then measure the variation of scale factor with respect to the corresponding cell temperature changes. Our experimental results show a good agreement with our theoretical analysis. Under our experimental condition, the error has been reduced significantly compared with those when the probe wavelength is adjusted to maximize the probe signal. The cost of this method is the reduction of the scale factor of the magnetometer. However, according to our analysis, it only has minor effect on the sensitivity under proper operating parameters.« less

  11. Spin-exchange relaxation-free magnetometer with nearly parallel pump and probe beams

    DOE PAGES

    Karaulanov, Todor; Savukov, Igor; Kim, Young Jin

    2016-03-22

    We constructed a spin-exchange relaxation-free (SERF) magnetometer with a small angle between the pump and probe beams facilitating a multi-channel design with a flat pancake cell. This configuration provides almost complete overlap of the beams in the cell, and prevents the pump beam from entering the probe detection channel. By coupling the lasers in multi-mode fibers, without an optical isolator or field modulation, we demonstrate a sensitivity of 10 fTmore » $$/\\sqrt{\\text{Hz}}$$ for frequencies between 10 Hz and 100 Hz. In addition to the experimental study of sensitivity, we present a theoretical analysis of SERF magnetometer response to magnetic fields for small-angle and parallel-beam configurations, and show that at optimal DC offset fields the magnetometer response is comparable to that in the orthogonal-beam configuration. Based on the analysis, we also derive fundamental and probe-limited sensitivities for the arbitrary non-orthogonal geometry. The expected practical and fundamental sensitivities are of the same order as those in the orthogonal geometry. As a result, we anticipate that our design will be useful for magnetoencephalography (MEG) and magnetocardiography (MCG) applications.« less

  12. The Mayo Clinic Value Creation System.

    PubMed

    Swensen, Stephen J; Dilling, James A; Harper, C Michel; Noseworthy, John H

    2012-01-01

    The authors present Mayo Clinic's Value Creation System, a coherent systems engineering approach to delivering a single high-value practice. There are 4 tightly linked, interdependent phases of the system: alignment, discovery, managed diffusion, and measurement. The methodology is described and examples of the results to date are presented. The Value Creation System has been demonstrated to improve the quality of patient care while reducing costs and increasing productivity.

  13. Solar forecast and real-time monitoring needs of the Study of Energy Release in Flares (SERF)

    NASA Technical Reports Server (NTRS)

    Rust, D. M.

    1979-01-01

    Complementary, simultaneous observations of flares from as many observatories, both ground based and orbiting, as possible planned for the Solar Maximum Year are considered. The need for forecasts of solar activity on long term, one week, and two day intervals is described. Real time reporting is not needed, but daily summaries of activity and permanent records are important.

  14. NASA's Global Change Master Directory: Discover and Access Earth Science Data Sets, Related Data Services, and Climate Diagnostics

    NASA Astrophysics Data System (ADS)

    Aleman, A.; Olsen, L. M.; Ritz, S.; Stevens, T.; Morahan, M.; Grebas, S. K.

    2011-12-01

    NASA's Global Change Master Directory provides the scientific community with the ability to discover, access, and use Earth science data, data-related services, and climate diagnostics worldwide.The GCMD offers descriptions of Earth science data sets using the Directory Interchange Format (DIF) metadata standard; Earth science related data services are described using the Service Entry Resource Format (SERF); and climate visualizations are described using the Climate Diagnostic (CD) standard. The DIF, SERF and CD standards each capture data attributes used to determine whether a data set, service, or climate visualization is relevant to a user's needs.Metadata fields include: title, summary, science keywords, service keywords, data center, data set citation, personnel, instrument, platform, quality, related URL, temporal and spatial coverage, data resolution and distribution information.In addition, nine valuable sets of controlled vocabularies have been developed to assist users in normalizing the search for data descriptions. An update to the GCMD's search functionality is planned to further capitalize on the controlled vocabularies during database queries.By implementing a dynamic keyword "tree", users will have the ability to search for data sets by combining keywords in new ways.This will allow users to conduct more relevant and efficient database searches to support the free exchange and re-use of Earth science data.

  15. Improving Information Products for System 2 Decision Support

    ERIC Educational Resources Information Center

    Gibson, Neal

    2010-01-01

    The creation, maintenance, and management of Information Product (IP) systems that are used by organizations for complex decisions represent a unique set of challenges. These challenges are compounded when the purpose of such a systems is also for knowledge creation and dissemination. Information quality research to date has focused mainly upon…

  16. JPRS Report, East Asia; Southeast Asia.

    DTIC Science & Technology

    1991-12-10

    Oct] 22 ECONOMIC Mahathir Says Country To Build Planes by 2020 [UTUSAN MALAYSIA 11 Oct] 22 Failure To Achieve Incorporation Lamented [UTUSAN...be able to handle this issue with patience and effectiveness. ECONOMIC Mahathir Says Country To Build Planes by 2020 92SE0058B Kuala Lumpur...UTUSANMALAYSIA in Malay 11 Oct 91 p 26 [Text] Jitra, 10 Oct—Prime Minister Datuk Serf Dr. Mahathir Mohamad says that by 2020 Malaysia will be a developed

  17. Estimating the Creation and Removal Date of Fracking Ponds Using Trend Analysis of Landsat Imagery.

    PubMed

    Platt, Rutherford V; Manthos, David; Amos, John

    2018-02-01

    Hydraulic fracturing, or fracking, is a process of introducing liquid at high pressure to create fractures in shale rock formations, thus releasing natural gas. Flowback and produced water from fracking operations is typically stored in temporary open-air earthen impoundments, or frack ponds. Unfortunately, in the United States there is no public record of the location of impoundments, or the dates that impoundments are created or removed. In this study we use a dataset of drilling-related impoundments in Pennsylvania identified through the FrackFinder project led by SkyTruth, an environmental non-profit. For each impoundment location, we compiled all low cloud Landsat imagery from 2000 to 2016 and created a monthly time series for three bands: red, near-infrared (NIR), and the Normalized Difference Vegetation Index (NDVI). We identified the approximate date of creation and removal of impoundments from sudden breaks in the time series. To verify our method, we compared the results to date ranges derived from photointerpretation of all available historical imagery on Google Earth for a subset of impoundments. Based on our analysis, we found that the number of impoundments built annually increased rapidly from 2006 to 2010, and then slowed from 2010 to 2013. Since newer impoundments tend to be larger, however, the total impoundment area has continued to increase. The methods described in this study would be appropriate for finding the creation and removal date of a variety of industrial land use changes at known locations.

  18. Estimating the Creation and Removal Date of Fracking Ponds Using Trend Analysis of Landsat Imagery

    NASA Astrophysics Data System (ADS)

    Platt, Rutherford V.; Manthos, David; Amos, John

    2018-02-01

    Hydraulic fracturing, or fracking, is a process of introducing liquid at high pressure to create fractures in shale rock formations, thus releasing natural gas. Flowback and produced water from fracking operations is typically stored in temporary open-air earthen impoundments, or frack ponds. Unfortunately, in the United States there is no public record of the location of impoundments, or the dates that impoundments are created or removed. In this study we use a dataset of drilling-related impoundments in Pennsylvania identified through the FrackFinder project led by SkyTruth, an environmental non-profit. For each impoundment location, we compiled all low cloud Landsat imagery from 2000 to 2016 and created a monthly time series for three bands: red, near-infrared (NIR), and the Normalized Difference Vegetation Index (NDVI). We identified the approximate date of creation and removal of impoundments from sudden breaks in the time series. To verify our method, we compared the results to date ranges derived from photointerpretation of all available historical imagery on Google Earth for a subset of impoundments. Based on our analysis, we found that the number of impoundments built annually increased rapidly from 2006 to 2010, and then slowed from 2010 to 2013. Since newer impoundments tend to be larger, however, the total impoundment area has continued to increase. The methods described in this study would be appropriate for finding the creation and removal date of a variety of industrial land use changes at known locations.

  19. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.

    PubMed

    Flannick, Jason; Thorleifsson, Gudmar; Beer, Nicola L; Jacobs, Suzanne B R; Grarup, Niels; Burtt, Noël P; Mahajan, Anubha; Fuchsberger, Christian; Atzmon, Gil; Benediktsson, Rafn; Blangero, John; Bowden, Don W; Brandslund, Ivan; Brosnan, Julia; Burslem, Frank; Chambers, John; Cho, Yoon Shin; Christensen, Cramer; Douglas, Desirée A; Duggirala, Ravindranath; Dymek, Zachary; Farjoun, Yossi; Fennell, Timothy; Fontanillas, Pierre; Forsén, Tom; Gabriel, Stacey; Glaser, Benjamin; Gudbjartsson, Daniel F; Hanis, Craig; Hansen, Torben; Hreidarsson, Astradur B; Hveem, Kristian; Ingelsson, Erik; Isomaa, Bo; Johansson, Stefan; Jørgensen, Torben; Jørgensen, Marit Eika; Kathiresan, Sekar; Kong, Augustine; Kooner, Jaspal; Kravic, Jasmina; Laakso, Markku; Lee, Jong-Young; Lind, Lars; Lindgren, Cecilia M; Linneberg, Allan; Masson, Gisli; Meitinger, Thomas; Mohlke, Karen L; Molven, Anders; Morris, Andrew P; Potluri, Shobha; Rauramaa, Rainer; Ribel-Madsen, Rasmus; Richard, Ann-Marie; Rolph, Tim; Salomaa, Veikko; Segrè, Ayellet V; Skärstrand, Hanna; Steinthorsdottir, Valgerdur; Stringham, Heather M; Sulem, Patrick; Tai, E Shyong; Teo, Yik Ying; Teslovich, Tanya; Thorsteinsdottir, Unnur; Trimmer, Jeff K; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Vaziri-Sani, Fariba; Voight, Benjamin F; Wilson, James G; Boehnke, Michael; McCarthy, Mark I; Njølstad, Pål R; Pedersen, Oluf; Groop, Leif; Cox, David R; Stefansson, Kari; Altshuler, David

    2014-04-01

    Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2 diabetes (T2D). Through sequencing or genotyping of ~150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. Collectively, carriers of protein-truncating variants had 65% reduced T2D risk (P = 1.7 × 10(-6)), and non-diabetic Icelandic carriers of a frameshift variant (p.Lys34Serfs*50) demonstrated reduced glucose levels (-0.17 s.d., P = 4.6 × 10(-4)). The two most common protein-truncating variants (p.Arg138* and p.Lys34Serfs*50) individually associate with T2D protection and encode unstable ZnT8 proteins. Previous functional study of SLC30A8 suggested that reduced zinc transport increases T2D risk, and phenotypic heterogeneity was observed in mouse Slc30a8 knockouts. In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention.

  20. Recent solar extreme ultraviolet irradiance observations and modeling: A review

    NASA Technical Reports Server (NTRS)

    Tobiska, W. Kent

    1993-01-01

    For more than 90 years, solar extreme ultraviolet (EUV) irradiance modeling has progressed from empirical blackbody radiation formulations, through fudge factors, to typically measured irradiances and reference spectra was well as time-dependent empirical models representing continua and line emissions. A summary of recent EUV measurements by five rockets and three satellites during the 1980s is presented along with the major modeling efforts. The most significant reference spectra are reviewed and threee independently derived empirical models are described. These include Hinteregger's 1981 SERF1, Nusinov's 1984 two-component, and Tobiska's 1990/1991/SERF2/EUV91 flux models. They each provide daily full-disk broad spectrum flux values from 2 to 105 nm at 1 AU. All the models depend to one degree or another on the long time series of the Atmosphere Explorer E (AE-E) EUV database. Each model uses ground- and/or space-based proxies to create emissions from solar atmospheric regions. Future challenges in EUV modeling are summarized including the basic requirements of models, the task of incorporating new observations and theory into the models, the task of comparing models with solar-terrestrial data sets, and long-term goals and modeling objectives. By the late 1990s, empirical models will potentially be improved through the use of proposed solar EUV irradiance measurements and images at selected wavelengths that will greatly enhance modeling and predictive capabilities.

  1. NASA's Global Change Master Directory: Discover and Access Earth Science Data Sets, Related Data Services, and Climate Diagnostics

    NASA Technical Reports Server (NTRS)

    Aleman, Alicia; Olsen, Lola; Ritz, Scott; Morahan, Michael; Cepero, Laurel; Stevens, Tyler

    2011-01-01

    NASA's Global Change Master Directory provides the scientific community with the ability to discover, access, and use Earth science data, data-related services, and climate diagnostics worldwide. The GCMD offers descriptions of Earth science data sets using the Directory Interchange Format (DIF) metadata standard; Earth science related data services are described using the Service Entry Resource Format (SERF); and climate visualizations are described using the Climate Diagnostic (CD) standard. The DIF, SERF and CD standards each capture data attributes used to determine whether a data set, service, or climate visualization is relevant to a user's needs. Metadata fields include: title, summary, science keywords, service keywords, data center, data set citation, personnel, instrument, platform, quality, related URL, temporal and spatial coverage, data resolution and distribution information. In addition, nine valuable sets of controlled vocabularies have been developed to assist users in normalizing the search for data descriptions. An update to the GCMD's search functionality is planned to further capitalize on the controlled vocabularies during database queries. By implementing a dynamic keyword "tree", users will have the ability to search for data sets by combining keywords in new ways. This will allow users to conduct more relevant and efficient database searches to support the free exchange and re-use of Earth science data. http://gcmd.nasa.gov/

  2. Historiography of the Greek Education: Creation, Development, Influences, Perspectives (1824-2006)

    ERIC Educational Resources Information Center

    Bouzakis, Sifis

    2009-01-01

    In this article, the presentation as well as the interpretation (in a historical framework) of the creation and development of the historiography of the Greek education from the foundation of the Modern Greek State to date was attempted. During the first decades after the liberation of Greece from the Turks, this historiography served the national…

  3. 26 CFR 1.642(c)-7 - Transitional rules with respect to pooled income funds.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... later, on the date of its creation and ending the day before the date on which it meets the requirements..., such share being based on the fair market value of the property in which such life interest was... value of the total commingled property on the date of separation. The percentage share shall be the...

  4. A novel frameshift mutation of CHD7 in a Japanese patient with CHARGE syndrome

    PubMed Central

    Kohmoto, Tomohiro; Shono, Miki; Naruto, Takuya; Watanabe, Miki; Suga, Ken-ichi; Nakagawa, Ryuji; Kagami, Shoji; Masuda, Kiyoshi; Imoto, Issei

    2016-01-01

    CHARGE syndrome is a rare autosomal dominant developmental disorder involving multiple organs. CHD7 is a major causative gene of CHARGE syndrome. We performed targeted-exome sequencing using a next-generation sequencer for molecular diagnosis of a 4-month-old male patient who was clinically suspected to have CHARGE syndrome, and report a novel monoallelic mutation in CHD7, NM_017780.3(CHD7_v001):c.2966del causing a reading frameshift [p.(Cys989Serfs*3)]. PMID:27081570

  5. A novel frameshift mutation of CHD7 in a Japanese patient with CHARGE syndrome.

    PubMed

    Kohmoto, Tomohiro; Shono, Miki; Naruto, Takuya; Watanabe, Miki; Suga, Ken-Ichi; Nakagawa, Ryuji; Kagami, Shoji; Masuda, Kiyoshi; Imoto, Issei

    2016-01-01

    CHARGE syndrome is a rare autosomal dominant developmental disorder involving multiple organs. CHD7 is a major causative gene of CHARGE syndrome. We performed targeted-exome sequencing using a next-generation sequencer for molecular diagnosis of a 4-month-old male patient who was clinically suspected to have CHARGE syndrome, and report a novel monoallelic mutation in CHD7, NM_017780.3(CHD7_v001):c.2966del causing a reading frameshift [p.(Cys989Serfs*3)].

  6. 45 CFR 164.316 - Policies and procedures and documentation requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) of this section for 6 years from the date of its creation or the date when it last was in effect... for implementing the procedures to which the documentation pertains. (iii) Updates (Required). Review documentation periodically, and update as needed, in response to environmental or operational changes affecting...

  7. 77 FR 59704 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... Advisor Disclosure Statement. Form: 8918. Abstract: The American Jobs Creation Act of 2004, Public Law 108... legislative districts as their tax homes. Affected Public: Individuals or Households. Estimated Total Burden..., Public Law 104-13, on or after the date of publication of this notice. DATES: Comments should be received...

  8. 26 CFR 53.4948-1 - Application of taxes and denial of exemption with respect to certain foreign organizations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the date of its creation has received at least 85 percent of its support (as defined in section 509(d... the date of death of the decedent. For example, assume that an individual gives money to a foreign...

  9. 6 CFR 13.21 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the return date, such date will be suspended pending the ALJ's final action on the motion. (4) The... the creation of a Document. (c) Motions for discovery. (1) A party seeking discovery may file a motion. Such a motion will be accompanied by a copy of the request for production of Documents, request for...

  10. Combined dendrochronological and radiocarbon dating of six Russian icons from the 15th-17th centuries

    NASA Astrophysics Data System (ADS)

    Dolgikh, A. V.; Matskovsky, V. V.; Voronin, K. V.; Solomina, O. N.

    2017-06-01

    The results of dendrochronological and radiocarbon dating by means of accelerator mass spectrometry (AMS) of six medieval icons, originating from northern European Russia and painted on wooden panels made from Scots pine, dated to the 15th to 17th centuries are presented. The panels of each icon were studied using dendrochronology. Five to six AMS dates were obtained for four icons. Although five icons were dendro-dated successfully, one failed to be reliably cross-dated with the existing master tree-ring chronologies and it was dated by radiocarbon wiggle-matching. Dendrochronological dating and wiggle-matching of radiocarbon dates allowed us to determine the narrow chronological intervals of icon creation.

  11. Triangular Mesh Generation of Elevation Versus Distance Course Profiles for use with Road Property Files

    DTIC Science & Technology

    2010-09-01

    Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions...the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503 1 . AGENCY USE ONLY (Leave blank) 2. REPORT DATE... 1 2.0 ROAD GEOMETRY CREATION ............................................................. 1 3.0 NODE AND ELEMENT CREATION

  12. 78 FR 14088 - Creation of a New System of Records Notice: Telework Application and Agreement Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-04

    ... audits. DATES: Persons wishing to comment on this system of records notice must do so by April 15, 2013... ENVIRONMENTAL PROTECTION AGENCY [FRL-9786-9; EPA-HQ-OEI-2012-0481] Creation of a New System of... proposes to create a new system of records pursuant to the provisions of the Privacy Act of 1974 (5 U.S.C...

  13. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

    PubMed Central

    Flannick, Jason; Thorleifsson, Gudmar; Beer, Nicola L.; Jacobs, Suzanne B. R.; Grarup, Niels; Burtt, Noël P.; Mahajan, Anubha; Fuchsberger, Christian; Atzmon, Gil; Benediktsson, Rafn; Blangero, John; Bowden, Don W.; Brandslund, Ivan; Brosnan, Julia; Burslem, Frank; Chambers, John; Cho, Yoon Shin; Christensen, Cramer; Douglas, Desirée A.; Duggirala, Ravindranath; Dymek, Zachary; Farjoun, Yossi; Fennell, Timothy; Fontanillas, Pierre; Forsén, Tom; Gabriel, Stacey; Glaser, Benjamin; Gudbjartsson, Daniel F.; Hanis, Craig; Hansen, Torben; Hreidarsson, Astradur B.; Hveem, Kristian; Ingelsson, Erik; Isomaa, Bo; Johansson, Stefan; Jørgensen, Torben; Jørgensen, Marit Eika; Kathiresan, Sekar; Kong, Augustine; Kooner, Jaspal; Kravic, Jasmina; Laakso, Markku; Lee, Jong-Young; Lind, Lars; Lindgren, Cecilia M; Linneberg, Allan; Masson, Gisli; Meitinger, Thomas; Mohlke, Karen L; Molven, Anders; Morris, Andrew P.; Potluri, Shobha; Rauramaa, Rainer; Ribel-Madsen, Rasmus; Richard, Ann-Marie; Rolph, Tim; Salomaa, Veikko; Segrè, Ayellet V.; Skärstrand, Hanna; Steinthorsdottir, Valgerdur; Stringham, Heather M.; Sulem, Patrick; Tai, E Shyong; Teo, Yik Ying; Teslovich, Tanya; Thorsteinsdottir, Unnur; Trimmer, Jeff K.; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Vaziri-Sani, Fariba; Voight, Benjamin F.; Wilson, James G.; Boehnke, Michael; McCarthy, Mark I.; Njølstad, Pål R.; Pedersen, Oluf; Groop, Leif; Cox, David R.; Stefansson, Kari; Altshuler, David

    2014-01-01

    Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets1,2,3, yet none are described for type 2 diabetes (T2D). Through sequencing or genotyping ~150,000 individuals across five ethnicities, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8)4 and harbors a common variant (p.Trp325Arg) associated with T2D risk, glucose, and proinsulin levels5–7. Collectively, protein-truncating variant carriers had 65% reduced T2D risk (p=1.7×10−6), and non-diabetic Icelandic carriers of a frameshift variant (p.Lys34SerfsX50) demonstrated reduced glucose levels (−0.17 s.d., p=4.6×10−4). The two most common protein-truncating variants (p.Arg138X and p.Lys34SerfsX50) individually associate with T2D protection and encode unstable ZnT8 proteins. Previous functional study of SLC30A8 suggested reduced zinc transport increases T2D risk8,9, yet phenotypic heterogeneity was observed in rodent Slc30a8 knockouts10–15. Contrastingly, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, proposing ZnT8 inhibition as a therapeutic strategy in T2D prevention. PMID:24584071

  14. Metadata Authoring with Versatility and Extensibility

    NASA Technical Reports Server (NTRS)

    Pollack, Janine; Olsen, Lola

    2004-01-01

    NASA's Global Change Master Directory (GCMD) assists the scientific community in the discovery of and linkage to Earth science data sets and related services. The GCMD holds over 13,800 data set descriptions in Directory Interchange Format (DIF) and 700 data service descriptions in Service Entry Resource Format (SERF), encompassing the disciplines of geology, hydrology, oceanography, meteorology, and ecology. Data descriptions also contain geographic coverage information and direct links to the data, thus allowing researchers to discover data pertaining to a geographic location of interest, then quickly acquire those data. The GCMD strives to be the preferred data locator for world-wide directory-level metadata. In this vein, scientists and data providers must have access to intuitive and efficient metadata authoring tools. Existing GCMD tools are attracting widespread usage; however, a need for tools that are portable, customizable and versatile still exists. With tool usage directly influencing metadata population, it has become apparent that new tools are needed to fill these voids. As a result, the GCMD has released a new authoring tool allowing for both web-based and stand-alone authoring of descriptions. Furthermore, this tool incorporates the ability to plug-and-play the metadata format of choice, offering users options of DIF, SERF, FGDC, ISO or any other defined standard. Allowing data holders to work with their preferred format, as well as an option of a stand-alone application or web-based environment, docBUlLDER will assist the scientific community in efficiently creating quality data and services metadata.

  15. Clinical aspects of Usher syndrome and the USH2A gene in a cohort of 433 patients.

    PubMed

    Blanco-Kelly, Fiona; Jaijo, Teresa; Aller, Elena; Avila-Fernandez, Almudena; López-Molina, María Isabel; Giménez, Ascensión; García-Sandoval, Blanca; Millán, José M; Ayuso, Carmen

    2015-02-01

    A new statistical approach is needed to describe the clinical differences between type I and type II Usher syndrome and between the 2 most frequent mutations in the USH2A gene. To describe the primary phenotypic characteristics and differences between type I and type II Usher syndrome and to establish a phenotype-genotype correlation for the 2 most frequent mutations in the USH2A gene. Cross-sectional study at a genetics department, in which clinical evaluations were performed for 433 patients (297 unrelated families) who were classified as having type I, II, III, atypical, or unclassified Usher syndrome according to their clinical history, pedigree data, results from ophthalmological studies, and audiological, neurophysiological, and vestibular test results. Molecular studies were performed for 304 patients (256 unrelated families). The Mann-Whitney U test or the χ2 test was used for calculating the differences between mean values for the analyzed parameters. Age at diagnosis; age at onset of night blindness, visual field loss, visual acuity loss, and cataracts; and severity and age at diagnosis of hearing loss. The comparison between patients with type I Usher syndrome and those with type II Usher syndrome revealed P < .001 for most items analyzed. The most frequent mutations in the USH2A gene were the p.Glu767Serfs*21 and p.Cys759Phe mutations, with an allelic frequency of 23.2% (63 of 272 alleles) and 8.1% (22 of 272 alleles), respectively. The phenotypic analysis for patients carrying p.Cys759Phe showed P < .001 for most items analyzed when compared with patients carrying p.Glu767Serfs*21 and when compared with patients carrying other mutations in the USH2A gene. None of the p.Cys759Phe patients exhibited a severe hearing loss phenotype, and more than 60% had only mild hearing loss. Most patients carrying the p.Glu767Serfs*21 mutation (72.1%) were moderately deaf. Our study presents the clinical differences between type I and type II Usher syndrome and between the 2 most frequent mutations in the USH2A gene. Detailed genotype-phenotype correlations, as presented in our study, allow for a better correlation of clinical signs with a known genotype and can improve the clinical management, genetic counseling, and risk assessment of patients with Usher syndrome because an estimated prognosis of their disease can be made.

  16. Primary microcephaly caused by novel compound heterozygous mutations in ASPM

    PubMed Central

    Okamoto, Nobuhiko; Kohmoto, Tomohiro; Naruto, Takuya; Masuda, Kiyoshi; Imoto, Issei

    2018-01-01

    Autosomal recessive primary microcephaly (microcephaly primary hereditary, MCPH) is a genetically heterogeneous rare developmental disorder that is characterized by prenatal onset of abnormal brain growth, which leads to intellectual disability of variable severity. We report a 5-year-old male who presented with a severe form of primary microcephaly. Targeted panel sequencing revealed compound heterozygous truncating mutations of the abnormal spindle-like microcephaly-associated (ASPM) gene, which confirmed the MCPH5 diagnosis. A novel NM_018136.4: c.9742_9745del (p.Lys3248Serfs*13) deletion mutation was identified. PMID:29644084

  17. Primary microcephaly caused by novel compound heterozygous mutations in ASPM.

    PubMed

    Okamoto, Nobuhiko; Kohmoto, Tomohiro; Naruto, Takuya; Masuda, Kiyoshi; Imoto, Issei

    2018-01-01

    Autosomal recessive primary microcephaly (microcephaly primary hereditary, MCPH) is a genetically heterogeneous rare developmental disorder that is characterized by prenatal onset of abnormal brain growth, which leads to intellectual disability of variable severity. We report a 5-year-old male who presented with a severe form of primary microcephaly. Targeted panel sequencing revealed compound heterozygous truncating mutations of the abnormal spindle-like microcephaly-associated ( ASPM ) gene, which confirmed the MCPH5 diagnosis. A novel NM_018136.4: c.9742_9745del (p.Lys3248Serfs*13) deletion mutation was identified.

  18. Mobile, Collaborative Situated Knowledge Creation for Urban Planning

    PubMed Central

    Zurita, Gustavo; Baloian, Nelson

    2012-01-01

    Geo-collaboration is an emerging research area in computer sciences studying the way spatial, geographically referenced information and communication technologies can support collaborative activities. Scenarios in which information associated to its physical location are of paramount importance are often referred as Situated Knowledge Creation scenarios. To date there are few computer systems supporting knowledge creation that explicitly incorporate physical context as part of the knowledge being managed in mobile face-to-face scenarios. This work presents a collaborative software application supporting visually-geo-referenced knowledge creation in mobile working scenarios while the users are interacting face-to-face. The system allows to manage data information associated to specific physical locations for knowledge creation processes in the field, such as urban planning, identifying specific physical locations, territorial management, etc.; using Tablet-PCs and GPS in order to geo-reference data and information. It presents a model for developing mobile applications supporting situated knowledge creation in the field, introducing the requirements for such an application and the functionalities it should have in order to fulfill them. The paper also presents the results of utility and usability evaluations. PMID:22778639

  19. Mobile, collaborative situated knowledge creation for urban planning.

    PubMed

    Zurita, Gustavo; Baloian, Nelson

    2012-01-01

    Geo-collaboration is an emerging research area in computer sciences studying the way spatial, geographically referenced information and communication technologies can support collaborative activities. Scenarios in which information associated to its physical location are of paramount importance are often referred as Situated Knowledge Creation scenarios. To date there are few computer systems supporting knowledge creation that explicitly incorporate physical context as part of the knowledge being managed in mobile face-to-face scenarios. This work presents a collaborative software application supporting visually-geo-referenced knowledge creation in mobile working scenarios while the users are interacting face-to-face. The system allows to manage data information associated to specific physical locations for knowledge creation processes in the field, such as urban planning, identifying specific physical locations, territorial management, etc.; using Tablet-PCs and GPS in order to geo-reference data and information. It presents a model for developing mobile applications supporting situated knowledge creation in the field, introducing the requirements for such an application and the functionalities it should have in order to fulfill them. The paper also presents the results of utility and usability evaluations.

  20. Tactical Network Load Balancing in Multi-Gateway Wireless Sensor Networks

    DTIC Science & Technology

    2013-12-01

    writeup scrsz = get( 0 ,’ScreenSize’); %Creation of the random Sensor Network fig = figure(1); set(fig, ’Position’,[1 scrsz( 4 )*.25 scrsz(3)*.7...thesis writeup scrsz = get( 0 ,’ScreenSize’); %Creation of the random Sensor Network fig = figure(1); set(fig, ’Position’,[1 scrsz( 4 )*.25 scrsz(3)*.7...TYPE AND DATES COVERED Master’s Thesis 4 . TITLE AND SUBTITLE TACTICAL NETWORK LOAD BALANCING IN MULTI-GATEWAY WIRELESS SENSOR NETWORKS 5

  1. Arima syndrome caused by CEP290 specific variant and accompanied with pathological cilium; clinical comparison with Joubert syndrome and its related diseases.

    PubMed

    Itoh, Masayuki; Ide, Shuhei; Iwasaki, Yuji; Saito, Takashi; Narita, Keishi; Dai, Hongmei; Yamakura, Shinji; Furue, Takeki; Kitayama, Hirotsugu; Maeda, Keiko; Takahashi, Eihiko; Matsui, Kiyoshi; Goto, Yu-Ichi; Takeda, Sen; Arima, Masataka

    2018-04-01

    Arima syndrome (AS) is a rare disease and its clinical features mimic those of Joubert syndrome or Joubert syndrome-related diseases (JSRD). Recently, we clarified the AS diagnostic criteria and its severe phenotype. However, genetic evidence of AS remains unknown. We explored causative genes of AS and compared the clinical and genetic features of AS with the other JSRD. We performed genetic analyses of 4 AS patients of 3 families with combination of whole-exome sequencing and Sanger sequencing. Furthermore, we studied cell biology with the cultured fibroblasts of 3 AS patients. All patients had a specific homozygous variant (c.6012-12T>A, p.Arg2004Serfs*7) or compound heterozygous variants (c.1711+1G>A; c.6012-12T>A, p.Gly570Aspfs*19;Arg2004Serfs*7) in centrosomal protein 290 kDa (CEP290) gene. These unique variants lead to abnormal splicing and premature termination. Morphological analysis of cultured fibroblasts from AS patients revealed a marked decrease of the CEP290-positive cell number with significantly longer cilium and naked and protruded ciliary axoneme without ciliary membrane into the cytoplasm. AS resulted in cilia dysfunction from centrosome disruption. The unique variant of CEP290 could be strongly linked to AS pathology. Here, we provided AS specific genetic evidence, which steers the structure and functions of centrosome that is responsible for normal ciliogenesis. This is the first report that has demonstrated the molecular basis of Arima syndrome. Copyright © 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  2. Screening of LDLR and APOB gene mutations in Mexican patients with homozygous familial hypercholesterolemia.

    PubMed

    Hernández Flores, Teresita De Jesús; González García, Juan Ramón; Colima Fausto, Ana Gabriela; Vázquez Cárdenas, Norma Alejandra; Sánchez López, Yoaly; Zarate Morales, César Augusto; Magaña Torres, María Teresa

    Familial hypercholesterolemia (FH) is an autosomal dominant disorder that causes accumulation of serum low-density lipoprotein cholesterol and premature cardiovascular disease. It is mainly related to mutations in the LDLR gene. Homozygous FH (HoFH) patients have the most severe form of the disease accounting for a worldwide prevalence of 1:1,000,000. In Mexico, at least 5 cases of HoFH have been reported. The aim of this study was to describe the clinical, biochemical, and molecular data observed in patients with HoFH phenotype. We included 13 patients, belonging to 11 families, with clinical and biochemical diagnoses suggestive of HoFH. Molecular analyses of the LDLR and APOB genes were performed by means of polymerase chain reaction followed by Sanger sequencing. The causal mutation of HoFH was found in 8 of 11 unrelated patients. Excepting 1, all were true homozygotes. Six different variants in LDLR were identified: c.-139delCTCCCCCTGC, p.Glu140Lys, p.Asp360His, p.Asn405Lys, p.Ala755Glyfs*7, and p.Leu759Serfs*6. Of these, p.Asp360His and p.Asn405Lys were detected for the first time in Mexico; p.Leu759Serfs*6 showed to be the most frequent (43.7% of the alleles 7/16), and c.-139delCTCCCCCTGC is a new variant located in the promoter region. This work increases knowledge of biochemical and genetic features in Mexican patients with HoFH. A novel mutation in the LDLR gene promoter was detected: c.-139delCTCCCCCTGC, which possibly inhibits its expression. Copyright © 2018 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  3. Modernizing the Estonian farmhouse, redefining the family, 1880s-1930s.

    PubMed

    L'Heureux, Marie-Alice

    2010-01-01

    In the nineteenth century, the transition from a Baltic-German-controlled manor-and-serf economy to individually owned farmsteads transformed all aspects of life including the spatial organization and form of farmhouses in the western provinces of Tsarist Russia. Agricultural experts and social reformers discussed how to update the traditional threshing-room dwelling house (rehielamu) into a healthy dwelling for successful farmers and, after the Estonian War of Independence, for new settlers. Using material culture such as contemporary plans, I show that changing household relationships, in addition to economic and technological factors, helped to transform the ancient rehielamu into a modern dwelling.

  4. Nanotechnology - Enabling Future Space Viability

    DTIC Science & Technology

    2009-03-18

    nanotechnology dates back to 1987 when K. Eric Drexler published Engines of Creation: The Coming Era of Nanotechnology; however, the concept itself...The Joint Operating Environment 2008, (Suffolk, VA: USFJCOM, 25 November 2008), 23. 14 Peter Eisler , “Commercial Satellites Alter Global Security

  5. Beginning of grain harvest in the tri-border region Basel as a proxy for mean April - May temperatures; creation of a long Swiss series c. 1455 AD - 1950 AD

    NASA Astrophysics Data System (ADS)

    Wetter, Oliver; Pfister, Christian

    2010-05-01

    Beginning of grain harvest in the tri-border region Basel as a proxy for mean April-July temperatures; creation of a long Swiss series c. 1454 AD - 1950 AD O. Wetter and C. Pfister Section of Economic, Social and Environmental History, Institute of History, University of Bern, Bern, Switzerland (oliver.wetter@hist.unibe.ch) Before agricultural harvesting machines replaced manual labour the date of the grain harvest was largely dependent on mean temperatures from spring to early summer. It thus constitutes a very valuable source of information to reconstruct these temperatures. The later the harvest began, the cooler spring and early summer must have been and vice versa. For this reconstruction a new data series of grain harvests in the tri-border region Basel (representative for north-west Switzerland, the Alsace (France) and south-west Germany) was used as a temperature proxy. The harvesting dates have been extracted from the account books of the hospital of Basel which cover the period from c.1454 AD to 1705 AD. This series could be completed with several series of grain tithe dates originating from the Swiss Midland, covering the period between 1557 and 1825 and several grain harvest dates series covering the time between 1825 and 1950. Thus a series of almost 500 years could be compiled. Since the method of harvesting remained unchanged until the 1950's when manual labour was replaced by machines, the harvest dates of the modern series, lying within the temperature measurement series, could be used for calibrating the medieval dates.

  6. Optimizing Coverage of Three-Dimensional Wireless Sensor Networks by Means of Photon Mapping

    DTIC Science & Technology

    2013-12-01

    information if it does not display a currently valid OMB control number. 1. REPORT DATE DEC 2013 2. REPORT TYPE 3. DATES COVERED 00-00-2013 to 00-00...information about the monitored space is sensed?” Solving this formulation of the AGP relies upon the creation of a model describing how a set of...simulated photons will propagate in a 3D virtual environment. Furthermore, the photon model requires an efficient data structure with small memory

  7. 49 CFR 1150.32 - Procedures and relevant dates-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... given to shippers. (c) If the notice contains false or misleading information, the exemption is void ab initio. A petition to revoke under 49 U.S.C. 10502(d) does not automatically stay the exemption. Stay...

  8. 76 FR 56128 - Retrospective Review of Existing Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ..., welfare, safety, and our environment while promoting economic growth, innovation, competitiveness, and job creation.'' In furtherance of its ongoing efforts to update regulations to reflect market developments and... Commission in considering the development of a plan for the retrospective review of its regulations. DATES...

  9. 39 CFR 262.6 - Retention and disposal.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of time between the creation of a series and its authorized disposal date; however, in some cases it... series that are maintained by components of the Postal Service; it provides maintenance, retention, transfer, and disposal instructions for each series listed, and serves as the authority for Postal...

  10. 39 CFR 262.6 - Retention and disposal.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of time between the creation of a series and its authorized disposal date; however, in some cases it... series that are maintained by components of the Postal Service; it provides maintenance, retention, transfer, and disposal instructions for each series listed, and serves as the authority for Postal...

  11. 39 CFR 262.6 - Retention and disposal.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of time between the creation of a series and its authorized disposal date; however, in some cases it... series that are maintained by components of the Postal Service; it provides maintenance, retention, transfer, and disposal instructions for each series listed, and serves as the authority for Postal...

  12. 39 CFR 262.6 - Retention and disposal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of time between the creation of a series and its authorized disposal date; however, in some cases it... series that are maintained by components of the Postal Service; it provides maintenance, retention, transfer, and disposal instructions for each series listed, and serves as the authority for Postal...

  13. 39 CFR 262.6 - Retention and disposal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of time between the creation of a series and its authorized disposal date; however, in some cases it... series that are maintained by components of the Postal Service; it provides maintenance, retention, transfer, and disposal instructions for each series listed, and serves as the authority for Postal...

  14. Employment Creation of Shale Gas Investment in China

    NASA Astrophysics Data System (ADS)

    Wang, Xuecheng; Zhang, Baosheng; Wu, Meiling; Li, Xiang; Lin, Yuying

    2018-01-01

    An ambitious shale gas extraction plan has been proposed. The huge investment of shale gas may put an effect on the whole China’s economy, especially for employment. However, there is few study to date has quantified these effects. The aim of this paper is to quantify these effects especially employment creation and figures out whether shale gas investment in China is a good choice or not. Input-output analysis has been utilized in this study to estimate the employment creation in four different Chinese regions. Our findings show that shale gas investment will result in creating 660000, 370000, 140000 and 58000 equivalent jobs in Sichuan, Chongqing, Inner Mongolia and Guizhou, respectively. Considering the potential risks of environmental issues, we suggest that it may be a better strategy for the government, at least in the current situation, to slow down shale gas development investment.

  15. Total Quality Management and Cost of Quality

    NASA Astrophysics Data System (ADS)

    Hadjicostas, Evsevios

    Before we start analysing the philosophy of Total Quality Management it is worthwhile going back to the early days of quality and the quality movement. In fact, the quality concept dates back to the creation of Adam and Eve: “And God saw every thing that he had made, and, behold, it was very good”. (Genesis A 31). It is remarkable that at the end of each day, looking at his creations God was saying, “This is good”. However, at the end of the sixth day, after he finished the creation of human beings, he said, “This is very good”. It is amazing that he did not say, “This is excellent”. This is because excellence is something that we gain after tireless effort. God left room for improvement in order to challenge us and make our life more attractive, which has really happened!

  16. 75 FR 14575 - Voting Equipment Evaluations Phase III

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ..., Human Performance-Based Standards and Usability Testing. NIST Phase III research is designed to: (1... vendor equipment will not be released. Comparative information may be released in a blind manner... electronic poll book systems as well as software used for ballot design and creation. Dated: March 23, 2010...

  17. Digital Media Production and Identity: Insights from a Psychological Perspective

    ERIC Educational Resources Information Center

    Terras, M. M.; Ramsay, J.; Boyle, E. A.

    2015-01-01

    The unprecedented opportunities for production and collaborative working supported by Web 2.0 technology offer immense potential for active knowledge creation. Research to date has mostly explored the demographic factors that influence production but we argue here that a more detailed understanding of the psychological determinants of online…

  18. Introducing the Date and Acquaintance Rape Avoidance Scale.

    PubMed

    Resendez, Josephine R; Hughes, Jamie S

    2016-01-01

    We present the Date and Acquaintance Rape Avoidance Scale (DARAS). The DARAS is a measure of a woman's behaviors used to avoid date and acquaintance rape. Three factor structures were possible. The DARAS may have measured several factors related to alcohol and drug use, self-defense, and date behaviors; 2 factors related to behaviors to avoid acquaintance versus date rape; or a single factor that represented general vigilance. The data revealed a highly reliable, 63 item single factor that was correlated with stranger rape avoidance, rejection of rape myths, hostile sexist beliefs about men, and benevolent sexist beliefs about women. The creation of the DARAS adds to the growing body of research on rape avoidance. The DARAS is key to understanding the behaviors women employ to avoid date rape. Rather than placing the responsibility for rape on the victim, the DARAS was developed as a theoretical and applied tool that can be used to improve theory and construct rape education and prevention programs.

  19. 77 FR 68070 - Implementing Public Safety Broadband Provisions of the Middle Class Tax Relief and Job Creation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ...; announcement of effective date. SUMMARY: On October 15, 2012, the Public Safety and Homeland Security Bureau...: Gene Fullano, Federal Communications Commission, Public Safety and Homeland Security Bureau, 445 12th... . SUPPLEMENTARY INFORMATION: On October 15, 2012, the Public Safety and Homeland Security Bureau (Bureau) of the...

  20. Finding the Age of the Earth by Physics or by Faith?

    ERIC Educational Resources Information Center

    Brush, Stephen G.

    1982-01-01

    Refutes scientific creationists' arguments that the earth is less than 10,000 years old by presenting information related to the time scales for creation and evolution models, times from stellar distances, Kelvin's estimate of the earth's age, radioactive decay, radiometric dating, and the decay of the earth's magnetic field. (DC)

  1. Applying Developmental Theory and Research to the Creation of Educational Games

    ERIC Educational Resources Information Center

    Revelle, Glenda

    2013-01-01

    The field of developmental psychology has produced abundant theory and research about the physical, cognitive, social, and emotional development of children; however, to date there has been limited use of this wealth of knowledge by developers creating games for children. This chapter provides an overview of key theoretical observations and…

  2. 76 FR 32404 - Proposed Collection; Comment Request for Form 8864

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-06

    ... 8864, Biodiesel Fuels Credit. DATES: Written comments should be received on or before August 5, 2011 to...: Biodiesel Fuels Credit. OMB Number: 1545-1924. Form Number: 8864. Abstract: The American Jobs Creation Act of 2004, section 302, added new code section 40A, credit for biodiesel used as a fuel. Form 8864 has...

  3. 78 FR 14939 - American Jobs Creation Act Modifications to Section 6708, Failure To Maintain List of Advisees...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... avoiding the person's list maintenance obligations imposed by section 6112 and its corresponding... (and any corresponding regulations) that was in effect on the date the material advisor's list... material advisor's reasonable cause for failing to provide the list on a specific day include facts and...

  4. [The first physician MP of the Hungarian Parliament, Vince Zomborcsevics].

    PubMed

    Dörnyei, Sándor

    2007-01-01

    Dr. Vince Zomborcsevics (1810-1890) was the first practising physician elected--in 1847 for the town Szabadka--as MP of the Hungarian Parliament. He spoke up twice at parliamentary sessions: first for enlarging the weight of towns in the Parliament (and thereby that of the bourgeoisie), while second time for radical changes to be made in serfs' circumstances. Both prior and following his parliamentary activity he worked as a medical officer, later he pursued private practice. In the 1840-ies he joined the contemporary national professional and cultural movements, from the 50-ies however he worked only for his local community. Later he retired from public life entirely. He left his remarkable book-collection to the local secondary school.

  5. Software to Compare NPP HDF5 Data Files

    NASA Technical Reports Server (NTRS)

    Wiegand, Chiu P.; LeMoigne-Stewart, Jacqueline; Ruley, LaMont T.

    2013-01-01

    This software was developed for the NPOESS (National Polar-orbiting Operational Environmental Satellite System) Preparatory Project (NPP) Science Data Segment. The purpose of this software is to compare HDF5 (Hierarchical Data Format) files specific to NPP and report whether the HDF5 files are identical. If the HDF5 files are different, users have the option of printing out the list of differences in the HDF5 data files. The user provides paths to two directories containing a list of HDF5 files to compare. The tool would select matching HDF5 file names from the two directories and run the comparison on each file. The user can also select from three levels of detail. Level 0 is the basic level, which simply states whether the files match or not. Level 1 is the intermediate level, which lists the differences between the files. Level 2 lists all the details regarding the comparison, such as which objects were compared, and how and where they are different. The HDF5 tool is written specifically for the NPP project. As such, it ignores certain attributes (such as creation_date, creation_ time, etc.) in the HDF5 files. This is because even though two HDF5 files could represent exactly the same granule, if they are created at different times, the creation date and time would be different. This tool is smart enough to ignore differences that are not relevant to NPP users.

  6. Dislocation creation and void nucleation in FCC ductile metals under tensile loading: a general microscopic picture.

    PubMed

    Pang, Wei-Wei; Zhang, Ping; Zhang, Guang-Cai; Xu, Ai-Guo; Zhao, Xian-Geng

    2014-11-10

    Numerous theoretical and experimental efforts have been paid to describe and understand the dislocation and void nucleation processes that are fundamental for dynamic fracture modeling of strained metals. To date an essential physical picture on the self-organized atomic collective motions during dislocation creation, as well as the essential mechanisms for the void nucleation obscured by the extreme diversity in structural configurations around the void nucleation core, is still severely lacking in literature. Here, we depict the origin of dislocation creation and void nucleation during uniaxial high strain rate tensile processes in face-centered-cubic (FCC) ductile metals. We find that the dislocations are created through three distinguished stages: (i) Flattened octahedral structures (FOSs) are randomly activated by thermal fluctuations; (ii) The double-layer defect clusters are formed by self-organized stacking of FOSs on the close-packed plane; (iii) The stacking faults are formed and the Shockley partial dislocations are created from the double-layer defect clusters. Whereas, the void nucleation is shown to follow a two-stage description. We demonstrate that our findings on the origin of dislocation creation and void nucleation are universal for a variety of FCC ductile metals with low stacking fault energies.

  7. 77 FR 66628 - Privacy Act of 1974, as Amended; Notice of a New System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... New System of Records AGENCY: Office of the Secretary, Interior. ACTION: Notice of creation of a new... Privacy Act records systems. DATES: Comments must be received by December 17, 2012. This new system will be effective December 17, 2012. ADDRESSES: Any person interested in commenting on this new system of...

  8. 75 FR 44246 - Petition For Rulemaking to Establish Procedures For The Creation and Amendment of Endangered...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... availability of a January 19, 2010 petition from Dow AgroSciences LLC (``DAS''), Makhteshim Agan of North... comment due to technical difficulties and cannot contact you for clarification, EPA may not be able to... (subject heading, Federal Register date and page number). ii. Follow directions. The Agency may ask you to...

  9. Education Researchers as Bricoleurs in the Creation of Sustainable Learning Environments

    ERIC Educational Resources Information Center

    Mahlomaholo, Sechaba

    2014-01-01

    Higher education has, to date, been unable to provide effective and lasting solutions to challenges of education, because large sections thereof continue to search for knowledge for its own sake. At best, they conduct responsive research, but on a small scale they reduce the complexity that is education to a neat unilinear process which can be…

  10. 26 CFR 1.881-4 - Recordkeeping requirements concerning conduit financing arrangements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... identification number (if any) and country of residence of— (A) Each person that advanced money or other property...) The date and amount of— (A) Each advance of money or other property or grant of rights; and (B) Each... maintenance in accordance with paragraph (b) of this section generally does not require the original creation...

  11. 75 FR 11512 - Consultative Group to Eliminate the Use of Child Labor and Forced Labor in Imported Agricultural...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... include three members from the agriculture-related private sector; two members from institutions of higher... the 2008 Farm Bill. The Act provides for the creation of the Consultative Group. DATES: March 18, 2010... the global supply chains within the agricultural sector or other industries; (b) The roles and...

  12. Libraries Use Broadband Internet Service to Serve High Need Communities. Data Note. Number 1

    ERIC Educational Resources Information Center

    Pastore, Erica; Henderson, Everett

    2009-01-01

    America needs greater access to broadband Internet to spur economic growth, innovation, and job creation. To date, gains in household broadband take-up are not evenly distributed across all demographic groups or geographic areas. While from 2001 to 2007, the percentage of households in the United States with access to broadband Internet services…

  13. Using age of colonizing douglas-fir for the dating of young geomorphic surfaces: a case study

    USGS Publications Warehouse

    Pierson, Thomas C.

    2013-01-01

    Dating of many types of young (<500 year), dynamic, geomorphic landforms (e.g. mass-movement erosional tracks and deposits, alluvial terraces, flood plains, etc.) for purposes of hazard assessment and mitigation commonly requires greater dating precision than is available through radiocarbon dating or other methods. Ages of trees growing on landform surfaces have been used in a number of studies to estimate the time of landform creation or surface clearing, but the time lag between surface formation or disturbance and the reestablishment of trees can vary from 1 to more than 200 years (Desloges and Ryder 1990; Frenzen et al. 1988, 2005; Larsen and Bliss 1998; McCarthy and Luckman 1993; Sigafoos and Hendricks 1969; Winter et al. 2002). Appropriate lag times for selected tree species and for particular climatic and altitudinal ranges must be determined for the method to be useful.

  14. Solar flux variability and the lifetimes of cometary H2O and OH

    NASA Astrophysics Data System (ADS)

    Budzien, S. A.; Festou, M. C.; Feldman, P. D.

    1994-01-01

    A solar EUV/FUV flux model based on recent SUSIM solar observations is presented. It is shown that both the fluxes and variabilities of the model are more consistent with SME and SUSIM solar spectrum measurements than those of the SERF1 model. It is calculated that photodissociation accounts for about 80 percent of the H2O destruction rate, while photoionization and solar wind particle interactions each account for about 10 percent of the H2O destruction. The calculated H2O and OH lifetimes against direct photodissociation both vary by 30 percent with solar activity. The major destruction channel for OH is predissociation, while direct photodissociation and solar wind interactions account for roughly 30 and 10 percent of the destruction rate, respectively.

  15. Understanding Different Levels of Group Functionality: Activity Systems Analysis of an Intercultural Telecollaborative Multilingual Digital Storytelling Project

    ERIC Educational Resources Information Center

    Priego, Sabrina; Liaw, Meei-Ling

    2017-01-01

    An Activity Theory framework has been increasingly applied for understanding the tension or contradictions in telecollaboration. However, to date, few researchers have applied it to the analysis of digital stories, and none of them, to our knowledge, have used it to analyze the co-creation of multilingual digital stories. In this study, we explore…

  16. Spinal Cord Injury Veterans: Disability Benefits, Outcomes, and Health Care Utilization Patterns

    DTIC Science & Technology

    2016-08-01

    PRINCIPAL INVESTIGATOR: Denise Fyffe, PhD ORGANIZATION : Kessler Medical Rehabilitation Research & Education Corporation West Orange, NJ 07052 REPORT DATE... research material (e.g., Germplasm; cell lines, DNA probes, animal models); • clinical interventions; • new business creation; and • other...the research , exchanged personnel, or otherwise contributed. Provide the following information for each partnership: Organization Name

  17. Dislocation creation and void nucleation in FCC ductile metals under tensile loading: A general microscopic picture

    PubMed Central

    Pang, Wei-Wei; Zhang, Ping; Zhang, Guang-Cai; Xu, Ai-Guo; Zhao, Xian-Geng

    2014-01-01

    Numerous theoretical and experimental efforts have been paid to describe and understand the dislocation and void nucleation processes that are fundamental for dynamic fracture modeling of strained metals. To date an essential physical picture on the self-organized atomic collective motions during dislocation creation, as well as the essential mechanisms for the void nucleation obscured by the extreme diversity in structural configurations around the void nucleation core, is still severely lacking in literature. Here, we depict the origin of dislocation creation and void nucleation during uniaxial high strain rate tensile processes in face-centered-cubic (FCC) ductile metals. We find that the dislocations are created through three distinguished stages: (i) Flattened octahedral structures (FOSs) are randomly activated by thermal fluctuations; (ii) The double-layer defect clusters are formed by self-organized stacking of FOSs on the close-packed plane; (iii) The stacking faults are formed and the Shockley partial dislocations are created from the double-layer defect clusters. Whereas, the void nucleation is shown to follow a two-stage description. We demonstrate that our findings on the origin of dislocation creation and void nucleation are universal for a variety of FCC ductile metals with low stacking fault energies. PMID:25382029

  18. Magnetoencephalography with a Cs-based high-sensitivity compact atomic magnetometer

    NASA Astrophysics Data System (ADS)

    Sheng, Jingwei; Wan, Shuangai; Sun, Yifan; Dou, Rongshe; Guo, Yuhao; Wei, Kequan; He, Kaiyan; Qin, Jie; Gao, Jia-Hong

    2017-09-01

    In recent years, substantial progress has been made in developing a new generation of magnetoencephalography (MEG) with a spin-exchange relaxation free (SERF)-based atomic magnetometer (AM). An AM employs alkali atoms to detect weak magnetic fields. A compact AM array with high sensitivity is crucial to the design; however, most proposed compact AMs are potassium (K)- or rubidium (Rb)-based with single beam configurations. In the present study, a pump-probe two beam configuration with a Cesium (Cs)-based AM (Cs-AM) is introduced to detect human neuronal magnetic fields. The length of the vapor cell is 4 mm, which can fully satisfy the need of designing a compact sensor array. Compared with state-of-the-art compact AMs, our new Cs-AM has two advantages. First, it can be operated in a SERF regime, requiring much lower heating temperature, which benefits the sensor with a closer distance to scalp due to ease of thermal insulation and less electric heating noise interference. Second, the two-beam configuration in the design can achieve higher sensitivity. It is free of magnetic modulation, which is necessary in one-beam AMs; however, such modulation may cause other interference in multi-channel circumstances. In the frequency band between 10 Hz and 30 Hz, the noise level of the proposed Cs-AM is approximately 10 f T/Hz1/2, which is comparable with state-of-the-art K- or Rb-based compact AMs. The performance of the Cs-AM was verified by measuring human auditory evoked fields (AEFs) in reference to commercial superconducting quantum interference device (SQUID) channels. By using a Cs-AM, we observed a clear peak in AEFs around 100 ms (M100) with a much larger amplitude compared with that of a SQUID, and the temporal profiles of the two devices were in good agreement. The results indicate the possibility of using the compact Cs-AM for MEG recordings, and the current Cs-AM has the potential to be designed for multi-sensor arrays and gradiometers for future neuroscience studies.

  19. A Computer Test as a Means to Assess Formation of the Teacher's Metasubject Competences

    ERIC Educational Resources Information Center

    Ansimova, Nina P.; Zolotariova, Angelina V.; Lekomtseva, Elena N.; Razumova, Anzhelika B.

    2017-01-01

    In the article here is up-to-dated the problem of creation and implementation of the complex system on measurement and assessment of the teachers' competences. Here are presented approaches and approbations of the computer test as a means to assess formation of the teacher's metasubject competences on the example of researching of the group of…

  20. A review on hydrothermal pre-treatment technologies and environmental profiles of algal biomass processing.

    PubMed

    Patel, Bhavish; Guo, Miao; Izadpanah, Arash; Shah, Nilay; Hellgardt, Klaus

    2016-01-01

    The need for efficient and clean biomass conversion technologies has propelled Hydrothermal (HT) processing as a promising treatment option for biofuel production. This manuscript discussed its application for pre-treatment of microalgae biomass to solid (biochar), liquid (biocrude and biodiesel) and gaseous (hydrogen and methane) products via Hydrothermal Carbonisation (HTC), Hydrothermal Liquefaction (HTL) and Supercritical Water Gasification (SCWG) as well as the utility of HT water as an extraction medium and HT Hydrotreatment (HDT) of algal biocrude. In addition, the Solar Energy Retained in Fuel (SERF) using HT technologies is calculated and compared with benchmark biofuel. Lastly, the Life Cycle Assessment (LCA) discusses the limitation of the current state of art as well as introduction to new potential input categories to obtain a detailed environmental profile. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. The Ethnic Factor in the Soviet Armed Forces. The Muslim Dimension

    DTIC Science & Technology

    1991-01-01

    Muslim conscripts into effective soldiers. The types of problems that a Muslim conscript presents for the Soviet military can be narrowed to two categories ... categories : ability and reliability. ETHNICITY AND DEMOGRAPHICS The major Soviet Muslim ethnic groups are creations of the Soviet regime, dating back to...avoid such embarrassments in the future. viii SOVIET MILITARY REFORM The predominantly coercive type of compliance previously used by the Soviet military

  2. Rapid Prototyping: State of the Art

    DTIC Science & Technology

    2003-10-23

    Rapid Prototyping SCS Solid Creation System SLM Selective Laser Melting SLP Solid Laser diode Plotter SLS Selective Laser Sintering SOAR State of the...121,000, respectively. SLP stands for Sold Laser Diode Plotter. The machines are relatively slow and parts are small, so, to date, the products have been...Gigerenzer, H., “Directed Laser Welding of Metal Matrix Composite Structures for Space Based Applications,“ Triton Systems Inc., Chelmsford, MA., 1

  3. Awaiting the Cyber 9/11

    DTIC Science & Technology

    2012-04-11

    REPORT TYPE 3. DATES COVERED (From- To) 11-04-2012 12, Master of Military Studies Research Paper Sep 2011 -Apr 2012 4. TITLE AND SUBTITLE Sa...DISCLAIMER THE OPINIONS AND CONCLUSIONS EXPRESSED HEREIN ARE THOSE OF THE INDIVIDUAL STUDENT AUTHOR AND DO NOT NECESSARILY REPRESENT THE...rely on firewalls to block attacks. This method is similar to the post World War I French creation of the Maginot Line.11 The Maginot Line was an

  4. Acute care surgery: impact on practice and economics of elective surgeons.

    PubMed

    Miller, Preston R; Wildman, Elizabeth A; Chang, Michael C; Meredith, J Wayne

    2012-04-01

    The creation of an acute care surgery service provides a rich operative experience for acute care surgeons. Elective surgeons typically have concerns about whether their practice volume will be restored with elective cases. Acute care surgery has financial implications for both groups. The aim of this project is to examine the impact in terms of work relative value units (wRVUs), collections, and cases in both groups with creation of an acute care surgery service at our institution. Work RVUs, collections, and case volume were examined from departmental records for 2 groups before and after acute care surgery service creation. The service began on September 1, 2008. Before this time, emergency surgical consults went to the general surgeon on call. After this date, all emergency consults were seen by acute care surgeons. The number of operations performed by the acute care surgery group increased significantly when the mean of the 2 years after institution of acute care surgery were compared with the mean of the 2 years preceding the service creation (1,639 vs 790/year; p = 0.007). There was no change in total operations done by the elective surgery group (2,763 vs 2,496/year: p = 0.13). Elective caseload, however, did increase by 23% in the elective surgery group. In the acute care surgery group, wRVUs increased by 140% and elective surgery group wRVUs decreased by 8%. Collections increased in both groups (acute care surgery 129%, elective surgery 7%) and the combined collections of the groups increased by $2,138,00 in the year after service creation. Acute care surgery service creation took emergency business from the elective surgery group, but this was almost immediately replaced with elective cases. This resulted in higher collections for both groups and a resultant significant increase in collections in aggregate. Copyright © 2012 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  5. JPRS Report Supplement, East Europe, Poland: Recent Legislation.

    DTIC Science & Technology

    1990-05-10

    national defense and Article 15. This Decree takes effect as of the day of its security as well as other tasks specified in special decrees...becomes, on the effective date of this Decree, as per 1) creation of conditions for the construction, mainte- the scope of his activities defined in...Navi- Article 10. This Decree takes effect on the day of itsArticle 4. 1. The Minister of Transportation and Nv- publication. gation performs his

  6. Highly Accurate Quantitative Analysis Of Enantiomeric Mixtures from Spatially Frequency Encoded 1H NMR Spectra.

    PubMed

    Plainchont, Bertrand; Pitoux, Daisy; Cyrille, Mathieu; Giraud, Nicolas

    2018-02-06

    We propose an original concept to measure accurately enantiomeric excesses on proton NMR spectra, which combines high-resolution techniques based on a spatial encoding of the sample, with the use of optically active weakly orienting solvents. We show that it is possible to simulate accurately dipolar edited spectra of enantiomers dissolved in a chiral liquid crystalline phase, and to use these simulations to calibrate integrations that can be measured on experimental data, in order to perform a quantitative chiral analysis. This approach is demonstrated on a chemical intermediate for which optical purity is an essential criterion. We find that there is a very good correlation between the experimental and calculated integration ratios extracted from G-SERF spectra, which paves the way to a general method of determination of enantiomeric excesses based on the observation of 1 H nuclei.

  7. Rare Compound Heterozygous Frameshift Mutations in ALMS1 Gene Identified Through Exome Sequencing in a Taiwanese Patient With Alström Syndrome.

    PubMed

    Tsai, Meng-Che; Yu, Hui-Wen; Liu, Tsunglin; Chou, Yen-Yin; Chiou, Yuan-Yow; Chen, Peng-Chieh

    2018-01-01

    Alström syndrome (AS) is a rare autosomal recessive disorder that shares clinical features with other ciliopathy-related diseases. Genetic mutation analysis is often required in making differential diagnosis but usually costly in time and effort using conventional Sanger sequencing. Herein we describe a Taiwanese patient presenting cone-rod dystrophy and early-onset obesity that progressed to diabetes mellitus with marked insulin resistance during adolescence. Whole exome sequencing of the patient's genomic DNA identified a novel frameshift mutation in exons 15 (c.10290_10291delTA, p.Lys3431Serfs * 10) and a rare mutation in 16 (c.10823_10824delAG, p.Arg3609Alafs * 6) of ALMS1 gene. The compound heterozygous mutations were predicted to render truncated proteins. This report highlighted the clinical utility of exome sequencing and extended the knowledge of mutation spectrum in AS patients.

  8. Room-temperature creation and spin-orbit torque-induced manipulation of skyrmions in thin film

    NASA Astrophysics Data System (ADS)

    Yu, Guoqiang; Upadhyaya, Pramey; Li, Xiang; Li, Wenyuan; Im, Se Kwon K.; Fan, Yabin; Wong, Kin L.; Tserkovnyak, Yaroslav; Amiri, Pedram Khalili; Wang, Kang L.

    Magnetic skyrmions, which are topologically protected spin texture, are promising candidates for ultra-low energy and ultra-high density magnetic data storage and computing applications1, 2. To date, most experiments on skyrmions have been carried out at low temperatures. The choice of materials available is limited and there is a lack of electrical means to control of skyrmions. Here, we experimentally demonstrate a method for creating skyrmion bubbles phase in the ferromagnetic thin film at room temperature. We further demonstrate that the created skyrmion bubbles can be manipulated by electric current. This room-temperature creation and manipulation of skyrmion in thin film is of particular interest for applications, being suitable for room-temperature operation and compatible with existing semiconductor manufacturing tools. 1. Nagaosa, N., Tokura, Y. Nature Nanotechnology 8, 899-911 (2013). 2. Fert, A., et al., Nature Nanotechnology 8, 152-156 (2013).

  9. Potential economic benefits of adapting agricultural production systems to future climate change

    USGS Publications Warehouse

    Fagre, Daniel B.; Pederson, Gregory; Bengtson, Lindsey E.; Prato, Tony; Qui, Zeyuan; Williams, Jimmie R.

    2010-01-01

    Potential economic impacts of future climate change on crop enterprise net returns and annual net farm income (NFI) are evaluated for small and large representative farms in Flathead Valley in Northwest Montana. Crop enterprise net returns and NFI in an historical climate period (1960–2005) and future climate period (2006–2050) are compared when agricultural production systems (APSs) are adapted to future climate change. Climate conditions in the future climate period are based on the A1B, B1, and A2 CO2 emission scenarios from the Intergovernmental Panel on Climate Change Fourth Assessment Report. Steps in the evaluation include: (1) specifying crop enterprises and APSs (i.e., combinations of crop enterprises) in consultation with locals producers; (2) simulating crop yields for two soils, crop prices, crop enterprises costs, and NFIs for APSs; (3) determining the dominant APS in the historical and future climate periods in terms of NFI; and (4) determining whether NFI for the dominant APS in the historical climate period is superior to NFI for the dominant APS in the future climate period. Crop yields are simulated using the Environmental/Policy Integrated Climate (EPIC) model and dominance comparisons for NFI are based on the stochastic efficiency with respect to a function (SERF) criterion. Probability distributions that best fit the EPIC-simulated crop yields are used to simulate 100 values for crop yields for the two soils in the historical and future climate periods. Best-fitting probability distributions for historical inflation-adjusted crop prices and specified triangular probability distributions for crop enterprise costs are used to simulate 100 values for crop prices and crop enterprise costs. Averaged over all crop enterprises, farm sizes, and soil types, simulated net return per ha averaged over all crop enterprises decreased 24% and simulated mean NFI for APSs decreased 57% between the historical and future climate periods. Although adapting APSs to future climate change is advantageous (i.e., NFI with adaptation is superior to NFI without adaptation based on SERF), in six of the nine cases in which adaptation is advantageous, NFI with adaptation in the future climate period is inferior to NFI in the historical climate period. Therefore, adaptation of APSs to future climate change in Flathead Valley is insufficient to offset the adverse impacts on NFI of such change.

  10. Mutations in MAB21L2 result in ocular Coloboma, microcornea and cataracts.

    PubMed

    Deml, Brett; Kariminejad, Ariana; Borujerdi, Razieh H R; Muheisen, Sanaa; Reis, Linda M; Semina, Elena V

    2015-01-01

    Ocular coloboma results from abnormal embryonic development and is often associated with additional ocular and systemic features. Coloboma is a highly heterogeneous disorder with many cases remaining unexplained. Whole exome sequencing from two cousins affected with dominant coloboma with microcornea, cataracts, and skeletal dysplasia identified a novel heterozygous allele in MAB21L2, c.151 C>G, p.(Arg51Gly); the mutation was present in all five family members with the disease and appeared de novo in the first affected generation of the three-generational pedigree. MAB21L2 encodes a protein similar to C. elegans mab-21 cell fate-determining factor; the molecular function of MAB21L2 is largely unknown. To further evaluate the role of MAB21L2, zebrafish mutants carrying a p.(Gln48Serfs*5) frameshift truncation (mab21l2Q48Sfs*5) and a p.(Arg51_Phe52del) in-frame deletion (mab21l2R51_F52del) were developed with TALEN technology. Homozygous zebrafish embryos from both lines developed variable lens and coloboma phenotypes: mab21l2Q48Sfs*5 embryos demonstrated severe lens and retinal defects with complete lethality while mab21l2R51_F52del mutants displayed a milder lens phenotype and severe coloboma with a small number of fish surviving to adulthood. Protein studies showed decreased stability for the human p.(Arg51Gly) and zebrafish p.(Arg51_Phe52del) mutant proteins and predicted a complete loss-of-function for the zebrafish p.(Gln48Serfs*5) frameshift truncation. Additionally, in contrast to wild-type human MAB21L2 transcript, mutant p.(Arg51Gly) mRNA failed to efficiently rescue the ocular phenotype when injected into mab21l2Q48Sfs*5 embryos, suggesting this allele is functionally deficient. Histology, immunohistochemistry, and in situ hybridization experiments identified retinal invagination defects, an increase in cell death, abnormal proliferation patterns, and altered expression of several ocular markers in the mab21l2 mutants. These findings support the identification of MAB21L2 as a novel factor involved in human coloboma and highlight the power of genome editing manipulation in model organisms for analysis of the effects of whole exome variation in humans.

  11. Potential economic benefits of adapting agricultural production systems to future climate change.

    PubMed

    Prato, Tony; Zeyuan, Qiu; Pederson, Gregory; Fagre, Dan; Bengtson, Lindsey E; Williams, Jimmy R

    2010-03-01

    Potential economic impacts of future climate change on crop enterprise net returns and annual net farm income (NFI) are evaluated for small and large representative farms in Flathead Valley in Northwest Montana. Crop enterprise net returns and NFI in an historical climate period (1960-2005) and future climate period (2006-2050) are compared when agricultural production systems (APSs) are adapted to future climate change. Climate conditions in the future climate period are based on the A1B, B1, and A2 CO(2) emission scenarios from the Intergovernmental Panel on Climate Change Fourth Assessment Report. Steps in the evaluation include: (1) specifying crop enterprises and APSs (i.e., combinations of crop enterprises) in consultation with locals producers; (2) simulating crop yields for two soils, crop prices, crop enterprises costs, and NFIs for APSs; (3) determining the dominant APS in the historical and future climate periods in terms of NFI; and (4) determining whether NFI for the dominant APS in the historical climate period is superior to NFI for the dominant APS in the future climate period. Crop yields are simulated using the Environmental/Policy Integrated Climate (EPIC) model and dominance comparisons for NFI are based on the stochastic efficiency with respect to a function (SERF) criterion. Probability distributions that best fit the EPIC-simulated crop yields are used to simulate 100 values for crop yields for the two soils in the historical and future climate periods. Best-fitting probability distributions for historical inflation-adjusted crop prices and specified triangular probability distributions for crop enterprise costs are used to simulate 100 values for crop prices and crop enterprise costs. Averaged over all crop enterprises, farm sizes, and soil types, simulated net return per ha averaged over all crop enterprises decreased 24% and simulated mean NFI for APSs decreased 57% between the historical and future climate periods. Although adapting APSs to future climate change is advantageous (i.e., NFI with adaptation is superior to NFI without adaptation based on SERF), in six of the nine cases in which adaptation is advantageous, NFI with adaptation in the future climate period is inferior to NFI in the historical climate period. Therefore, adaptation of APSs to future climate change in Flathead Valley is insufficient to offset the adverse impacts on NFI of such change.

  12. Kaizen newspaper

    NASA Technical Reports Server (NTRS)

    Shearer, Scott C. (Inventor); Proferes, John Nicholas (Inventor); Baker, Sr., Mitchell D. (Inventor); Reilly, Kenneth B. (Inventor); Tiwari, Vijai K. (Inventor)

    2013-01-01

    Systems, computer program products, and methods are disclosed for tracking an improvement event. An embodiment includes an event interface configured to receive a plurality of entries related to each of a plurality of improvement events. The plurality of entries includes a project identifier for the improvement event, a creation date, an objective, an action related to reaching the objective, and a first deadline related to the improvement event. A database interface is configured to store the plurality of entries in an event database.

  13. Building Better Armies: An Insider’s Account of Liberia

    DTIC Science & Technology

    2013-11-01

    penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE NOV 2013 2... inform different ideas about security may not easily translate into a coherent and actionable national se- curity strategy. The human security perspective...and relevance, and by support- 17 ing the creation of a balanced and effective security sector, informed by a clear understanding of its objec- tives

  14. An Assessment on the Creation of an Under Secretary of Defense for Business Management and Information

    DTIC Science & Technology

    2016-04-21

    whether the position should be consolidated and elevated, assess the advantages and disadvantages of doing so, and such other matters as the DBB... disadvantages of the legislation, the Task Group worked to: – Understand the existing DoD structure, and how it evolved to-date – Understand private...Board in the public meeting held April 21, 2016. 14 Findings: The Legislation Perceived Disadvantages : (slide 1 of 3)  Talent Considerations

  15. Living systematic reviews: an emerging opportunity to narrow the evidence-practice gap.

    PubMed

    Elliott, Julian H; Turner, Tari; Clavisi, Ornella; Thomas, James; Higgins, Julian P T; Mavergames, Chris; Gruen, Russell L

    2014-02-01

    The current difficulties in keeping systematic reviews up to date leads to considerable inaccuracy, hampering the translation of knowledge into action. Incremental advances in conventional review updating are unlikely to lead to substantial improvements in review currency. A new approach is needed. We propose living systematic review as a contribution to evidence synthesis that combines currency with rigour to enhance the accuracy and utility of health evidence. Living systematic reviews are high quality, up-to-date online summaries of health research, updated as new research becomes available, and enabled by improved production efficiency and adherence to the norms of scholarly communication. Together with innovations in primary research reporting and the creation and use of evidence in health systems, living systematic review contributes to an emerging evidence ecosystem.

  16. BP Spill Sampling and Monitoring Data

    EPA Pesticide Factsheets

    This dataset analyzes waste from the the British Petroleum Deepwater Horizon Rig Explosion Emergency Response, providing opportunity to query data sets by metadata criteria and find resulting raw datasets in CSV format.The data query tool allows users to download EPA's air, water and sediment sampling and monitoring data that has been collected in response to the BP oil spill. All sampling and monitoring data that has been collected to date is available for download as raw structured data.The query tools enables CSV file creation to be refined based on the following search criteria: date range (between April 28, 2010 and 9/29/2010); location by zip, city, or county; media (solid waste, weathered oil, air, surface water, liquid waste, tar, sediment, water); substance categories (based on media selection) and substances (based on substance category selection).

  17. Comparing Digital Flood Insurance Rate Maps (DFIRMs) to Interferometric Synthetic Aperture Radar (IFSAR) Products

    DTIC Science & Technology

    2000-09-01

    specifications and procedures call for the use of Digital Orthophoto Quarter Quadrangles (DOQs) produced by the USGS to be the default base map if...egm96.html (14 September 2000). USGS. “Digital Orthophoto Quadrangles”, http://www-wmc.wr.usgs.gov/doq (7 November 2000). United States Naval...Technologies Inc. Global Terrain Metadata File (DEM) File Creation date: Wednesday, June 02, 1999 Tile Identifier #: GT1N36W075H8V1.bil Project Area

  18. Los Angeles-Long Beach Harbor Areas Prehistory and Early History, Los Angeles County, California,

    DTIC Science & Technology

    1978-04-01

    H - R136 656 LOS ANGELES-LONG BEACH HARBOR ARE AS PREHISTORY AND I/i EARLY HISTORY LO S ANGELES COUNTY CALIFORNIA(U) ARMY ENGINEER DISTRICT LOS...world. The The Early Systems Period (50,000? to 7,000 creation of this megalopolis, unfortunately, years ago) had severe impacts on the natural...called amino acid dating. Using this of early occupation. There is data which system , archeologists determined that human suggests that some of the

  19. The VALiDATe29 MRI Based Multi-Channel Atlas of the Squirrel Monkey Brain.

    PubMed

    Schilling, Kurt G; Gao, Yurui; Stepniewska, Iwona; Wu, Tung-Lin; Wang, Feng; Landman, Bennett A; Gore, John C; Chen, Li Min; Anderson, Adam W

    2017-10-01

    We describe the development of the first digital atlas of the normal squirrel monkey brain and present the resulting product, VALiDATe29. The VALiDATe29 atlas is based on multiple types of magnetic resonance imaging (MRI) contrast acquired on 29 squirrel monkeys, and is created using unbiased, nonlinear registration techniques, resulting in a population-averaged stereotaxic coordinate system. The atlas consists of multiple anatomical templates (proton density, T1, and T2* weighted), diffusion MRI templates (fractional anisotropy and mean diffusivity), and ex vivo templates (fractional anisotropy and a structural MRI). In addition, the templates are combined with histologically defined cortical labels, and diffusion tractography defined white matter labels. The combination of intensity templates and image segmentations make this atlas suitable for the fundamental atlas applications of spatial normalization and label propagation. Together, this atlas facilitates 3D anatomical localization and region of interest delineation, and enables comparisons of experimental data across different subjects or across different experimental conditions. This article describes the atlas creation and its contents, and demonstrates the use of the VALiDATe29 atlas in typical applications. The atlas is freely available to the scientific community.

  20. BP Spill Sampling and Monitoring Data April-September 2010 - Data Download Tool

    EPA Pesticide Factsheets

    This dataset analyzes waste from the the British Petroleum Deepwater Horizon Rig Explosion Emergency Response, providing opportunity to query data sets by metadata criteria and find resulting raw datasets in CSV format.The data query tool allows users to download air, water and sediment sampling and monitoring data that has been collected in response to the BP oil spill. All sampling and monitoring data that has been collected to date is available for download as raw structured data.The query tools enables CSV file creation to be refined based on the following search criteria: date range (between April 28, 2010 and 9/29/2010); location by zip, city, or county; media (solid waste, weathered oil, air, surface water, liquid waste, tar, sediment, water); substance categories (based on media selection) and substances (based on substance category selection).

  1. BigDog

    NASA Astrophysics Data System (ADS)

    Playter, R.; Buehler, M.; Raibert, M.

    2006-05-01

    BigDog's goal is to be the world's most advanced quadruped robot for outdoor applications. BigDog is aimed at the mission of a mechanical mule - a category with few competitors to date: power autonomous quadrupeds capable of carrying significant payloads, operating outdoors, with static and dynamic mobility, and fully integrated sensing. BigDog is about 1 m tall, 1 m long and 0.3 m wide, and weighs about 90 kg. BigDog has demonstrated walking and trotting gaits, as well as standing up and sitting down. Since its creation in the fall of 2004, BigDog has logged tens of hours of walking, climbing and running time. It has walked up and down 25 & 35 degree inclines and trotted at speeds up to 1.8 m/s. BigDog has walked at 0.7 m/s over loose rock beds and carried over 50 kg of payload. We are currently working to expand BigDog's rough terrain mobility through the creation of robust locomotion strategies and terrain sensing capabilities.

  2. A novel 5-bp deletion in Clarin 1 in a family with Usher syndrome.

    PubMed

    Akoury, Elie; El Zir, Elie; Mansour, Ahmad; Mégarbané, André; Majewski, Jacek; Slim, Rima

    2011-11-01

    To identify the genetic defect in a Lebanese family with two sibs diagnosed with Usher Syndrome. Exome capture and sequencing were performed on DNA from one affected member using Agilent in solution bead capture, followed by Illumina sequencing. This analysis revealed the presence of a novel homozygous 5-bp deletion, in Clarin 1 (CLRN1), a known gene responsible for Usher syndrome type III. The deletion is inherited from both parents and segregates with the disease phenotype in the family. The 5-bp deletion, c.301_305delGTCAT, p.Val101SerfsX27, is predicted to result in a frameshift and protein truncation after 27 amino acids. Sequencing all the coding regions of the CLRN1 gene in the proband did not reveal any other mutation or variant. Here we describe a novel deletion in CLRN1. Our data support previously reported intra familial variability in the clinical features of Usher syndrome type I and III.

  3. Host Range of a Population of Pratylenchus vulnus in Commercial Fruit, Nut, Citrus, and Grape Rootstocks in Spain.

    PubMed

    Pinochet, J; Verdejo, S; Soler, A; Canals, J

    1992-12-01

    In a host-range study carried out under greenhouse conditions, a total of 37 commercial fruit tree, grape, and citrus rootstocks were tested for their reaction to a population of the lesion nematode, Pratylenchus vulnus, in Spain. Twenty-five rootstocks had a Pf/Pi > 1.5. These included almond (Desmayo Rojo, 1143), apple (EM-9, EM-106), avocado (Hass), cherry (Santa Lucia 64, Camil, M x M 14, Masto de Montafiana), grape (41-B, Fercal, Ritcher 110), hazelnut (Pauetet), loquat (Nadal), peach (Montclar, GF-305), pear (OHF-333), pistachio (P. atlantica, P. vera, P. terebinthus), plum (San Julian 655-2, Montizo, Pixy, Myrobalan 605), and walnut (Serf). The peach rootstock Nemaguard and the grape 161-49 had Pf/Pi between 1.0 and 1.5 (slightly higher than inoculation level). All the tested citrus (Alemow, rough lemon, Carrizo citrange, sour orange, Troyer citrange, Citrumelo), plus three grape (SO4, Vitis rupestris, 1103-P), and the olive rootstock Arbequina had a Pf/Pi < 1.0.

  4. Intelligent Design and the Creationism/Evolution Controversy

    NASA Astrophysics Data System (ADS)

    Scott, E. C.

    2004-12-01

    "Intelligent Design" (ID) is a new form of creationism that emerged after legal decisions in the 1980s hampered the inclusion of "creation science" in the public school curriculum. To avoid legal challenge, proponents claim agnosticism regarding the identity of the intelligent agent, which could be material (such as highly intelligent terrestrials) or transcendental (God). ID consists of a scientific/scholarly effort, and a politico-religious movement of "cultural renewal." Intelligent design is supposedly detectable through the application of Michael Behe's "irreducible complexity" concept and/or William Dembski's concept of "complex specified information". ID's claims amount to, first, that "Darwinism" (vaguely defined) is incapable of providing an adequate mechanism for evolution, and second (subsequently), that evolution did not occur. Although scientific ideas not infrequently are slow to be accepted, in the 20 years since ID appeared, there is no evidence of it being used to solve problems in biology. Even if the scientific/scholarly part of ID has been a failure, the "cultural renewal" part of ID has been a success. This social and political aspect of ID seeks "restoration" of a theistic sensibility in American culture to replace what supporters consider an overemphasis on secularism. In the last few years, in several states, legislators have introduced legislation promoting ID (to date, unsuccessfully) and an addendum to the 2001 federal education bill conference committee report (the "Santorum amendment") is being used to promote the teaching of ID in public schools. Perhaps because ID has no actual content other than antievolutionism, ID proponents contend that pre-college teachers should teach wweaknesses of evolutionw or "evidence against evolutionw - largely warmed-over arguments from creation science - even though professional scientists do not recognize these as valid scientific claims.

  5. Creation of Integrated System of Cosmonauts Sanitary-Hygienic Supply: Researches, Problems and Prospects

    NASA Astrophysics Data System (ADS)

    Shumilina, I.; Krivobok, S.; Shumilina, G.

    The necessity of Integrated System creation for cosmonauts Sanitary - Hygienic Supply has appeared at realization of joint flights on the International Space Station (ISS). Russian hygiene means manufactured and tested in the long space flights conditions and personal hygiene means of foreign manufacture, which were developed without chamber experiments conditions, are mean to use for Integrated System. The realization of Sanitary - Hygienic Water (SHW) regeneration is supposed for water circulation. The researches directed on equipment creation for clothing washing and clothing drying were carried out for the purposes of goods turnover optimization on ISS The variants of possible realization of water procedures (shower-bath, face washing) are studied. New and essentially date are received for an estimation of efficiency of various ways of cosmonauts Sanitary - Hygienic Supply, including results of tests for new generation regeneration SHW systems with Nanofiltration unit on various kinds real SHW. The improvement of washing-up liquids, individual selection of a complex of personal hygiene means with the man skin condition registration allows to raise of preventive measures use efficiency directed on prevention of adverse skin changes and skin diseases. The analysis of the equipment and methods for clothing washing and clothing drying for conditions of long space flight are carried out. The experimental data on textile materials drying are received. The investigations covered a wide range of issues associated with Sanitary - Hygienic Supply Integrated System including Personal Hygiene complex (items and techniques), ways of Sanitary - Hygienic Supply realization, methods of wastewater regeneration. The results of researches are especially urgent for cosmonauts Sanitary - Hygienic Supply System creation for long space flights, in particular, "Mars" flights at impossibility of updating of water stock, clothing stock etc.

  6. Automatic indexing of scanned documents: a layout-based approach

    NASA Astrophysics Data System (ADS)

    Esser, Daniel; Schuster, Daniel; Muthmann, Klemens; Berger, Michael; Schill, Alexander

    2012-01-01

    Archiving official written documents such as invoices, reminders and account statements in business and private area gets more and more important. Creating appropriate index entries for document archives like sender's name, creation date or document number is a tedious manual work. We present a novel approach to handle automatic indexing of documents based on generic positional extraction of index terms. For this purpose we apply the knowledge of document templates stored in a common full text search index to find index positions that were successfully extracted in the past.

  7. Magnetic helicity and flux tube dynamics in the solar convection zone: Comparisons between observation and theory

    NASA Astrophysics Data System (ADS)

    Nandy, Dibyendu

    2006-12-01

    Magnetic helicity, a conserved topological parameter in ideal MHD systems, conditions close to which are realized in the solar plasma, is intimately connected to the creation and subsequent dynamics of magnetic flux tubes in the solar interior. It can therefore be used as a tool to probe such dynamics. In this paper we show how photospheric observations of magnetic helicity of isolated magnetic flux tubes, manifested as the twist and writhe of solar active regions, can constrain the creation and dynamics of flux tubes in the solar convection zone and the nature of convective turbulence itself. We analyze the observed latitudinal distribution of twists in photospheric active regions, derived from solar vector magnetograms, in the largest such sample studied till-date. We confirm and put additional constraints on the hemispheric twist helicity trend and find that the dispersion in the active region twist distribution is latitude-independent, implying that the amplitude of turbulent fluctuations does not vary with latitude in the convection zone. Our data set also shows that the amplitude and dispersion of twist decreases with increasing magnetic size of active regions, supporting the conclusion that larger flux tubes are less affected by turbulence. Among the various theoretical models that have been proposed till-date to explain the origin of twist, our observations best match the Σ effect model, which invokes helical turbulent buffeting of rising flux tubes as the mechanism for twist creation. Finally, we complement our analysis of twists with past observations of tilts in solar active regions and tie them in with theoretical modeling studies, to build up a comprehensive picture of the dynamics of twisted magnetic flux tubes throughout the solar convection zone. This general framework, binding together theory and observations, suggests that flux tubes have a wide range of twists in the solar convection zone, with some as high as to make them susceptible to the kink instability mechanism that results in the formation of δ spot or non-Hale active regions.

  8. Teaching resources for dermatology on the WWW--quiz system and dynamic lecture scripts using a HTTP-database demon.

    PubMed Central

    Bittorf, A.; Diepgen, T. L.

    1996-01-01

    The World Wide Web (WWW) is becoming the major way of acquiring information in all scientific disciplines as well as in business. It is very well suitable for fast distribution and exchange of up to date teaching resources. However, to date most teaching applications on the Web do not use its full power by integrating interactive components. We have set up a computer based training (CBT) framework for Dermatology, which consists of dynamic lecture scripts, case reports, an atlas and a quiz system. All these components heavily rely on an underlying image database that permits the creation of dynamic documents. We used a demon process that keeps the database open and can be accessed using HTTP to achieve better performance and avoid the overhead involved by starting CGI-processes. The result of our evaluation was very encouraging. Images Figure 3 PMID:8947625

  9. Age of Barrier Canyon-style rock art constrained by cross-cutting relations and luminescence dating techniques.

    PubMed

    Pederson, Joel L; Chapot, Melissa S; Simms, Steven R; Sohbati, Reza; Rittenour, Tammy M; Murray, Andrew S; Cox, Gary

    2014-09-09

    Rock art compels interest from both researchers and a broader public, inspiring many hypotheses about its cultural origin and meaning, but it is notoriously difficult to date numerically. Barrier Canyon-style (BCS) pictographs of the Colorado Plateau are among the most debated examples; hypotheses about its age span the entire Holocene epoch and previous attempts at direct radiocarbon dating have failed. We provide multiple age constraints through the use of cross-cutting relations and new and broadly applicable approaches in optically stimulated luminescence dating at the Great Gallery panel, the type section of BCS art in Canyonlands National Park, southeastern Utah. Alluvial chronostratigraphy constrains the burial and exhumation of the alcove containing the panel, and limits are also set by our related research dating both a rockfall that removed some figures and the rock's exposure duration before that time. Results provide a maximum possible age, a minimum age, and an exposure time window for the creation of the Great Gallery panel, respectively. The only prior hypothesis not disproven is a late Archaic origin for BCS rock art, although our age result of A.D. ∼ 1-1100 coincides better with the transition to and rise of the subsequent Fremont culture. This chronology is for the type locality only, and variability in the age of other sites is likely. Nevertheless, results suggest that BCS rock art represents an artistic tradition that spanned cultures and the transition from foraging to farming in the region.

  10. Age of Barrier Canyon-style rock art constrained by cross-cutting relations and luminescence dating techniques

    PubMed Central

    Pederson, Joel L.; Chapot, Melissa S.; Simms, Steven R.; Sohbati, Reza; Rittenour, Tammy M.; Murray, Andrew S.; Cox, Gary

    2014-01-01

    Rock art compels interest from both researchers and a broader public, inspiring many hypotheses about its cultural origin and meaning, but it is notoriously difficult to date numerically. Barrier Canyon-style (BCS) pictographs of the Colorado Plateau are among the most debated examples; hypotheses about its age span the entire Holocene epoch and previous attempts at direct radiocarbon dating have failed. We provide multiple age constraints through the use of cross-cutting relations and new and broadly applicable approaches in optically stimulated luminescence dating at the Great Gallery panel, the type section of BCS art in Canyonlands National Park, southeastern Utah. Alluvial chronostratigraphy constrains the burial and exhumation of the alcove containing the panel, and limits are also set by our related research dating both a rockfall that removed some figures and the rock’s exposure duration before that time. Results provide a maximum possible age, a minimum age, and an exposure time window for the creation of the Great Gallery panel, respectively. The only prior hypothesis not disproven is a late Archaic origin for BCS rock art, although our age result of A.D. ∼1–1100 coincides better with the transition to and rise of the subsequent Fremont culture. This chronology is for the type locality only, and variability in the age of other sites is likely. Nevertheless, results suggest that BCS rock art represents an artistic tradition that spanned cultures and the transition from foraging to farming in the region. PMID:25157162

  11. Association between vascular access creation and deceleration of estimated glomerular filtration rate decline in late-stage chronic kidney disease patients transitioning to end-stage renal disease.

    PubMed

    Sumida, Keiichi; Molnar, Miklos Z; Potukuchi, Praveen K; Thomas, Fridtjof; Lu, Jun Ling; Ravel, Vanessa A; Soohoo, Melissa; Rhee, Connie M; Streja, Elani; Yamagata, Kunihiro; Kalantar-Zadeh, Kamyar; Kovesdy, Csaba P

    2017-08-01

    Prior studies have suggested that arteriovenous fistula (AVF) or graft (AVG) creation may be associated with slowing of estimated glomerular filtration rate (eGFR) decline. It is unclear if this is attributable to the physiological benefits of a mature access on systemic circulation versus confounding factors. We examined a nationwide cohort of 3026 US veterans with advanced chronic kidney disease (CKD) transitioning to dialysis between 2007 and 2011 who had a pre-dialysis AVF/AVG and had at least three outpatient eGFR measurements both before and after AVF/AVG creation. Slopes of eGFR were estimated using mixed-effects models adjusted for fixed and time-dependent confounders, and compared separately for the pre- and post-AVF/AVG period overall and in patients stratified by AVF/AVG maturation. In all, 3514 patients without AVF/AVG who started dialysis with a catheter served as comparators, using an arbitrary 6-month index date before dialysis initiation to assess change in eGFR slopes. Of the 3026 patients with AVF/AVG (mean age 67 years, 98% male, 75% diabetic), 71% had a mature AVF/AVG at dialysis initiation. eGFR decline accelerated in the last 6 months prior to dialysis in patients with a catheter (median, from -6.0 to -16.3 mL/min/1.73 m2/year, P < 0.001), while a significant deceleration of eGFR decline was seen after vascular access creation in those with AVF/AVG (median, from -5.6 to -4.1 mL/min/1.73 m2/year, P < 0.001). Findings were independent of AVF/AVG maturation status and were robust in adjusted models. The creation of pre-dialysis AVF/AVG appears to be associated with eGFR slope deceleration and, consequently, may delay the onset of dialysis initiation in advanced CKD patients. Published by Oxford University Press on behalf of ERA-EDTA 2016. This work is written by US Government employees and is in the public domain in the US.

  12. Room-Temperature Creation and Spin–Orbit Torque Manipulation of Skyrmions in Thin Films with Engineered Asymmetry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yu, Guoqiang; Upadhyaya, Pramey; Li, Xiang

    2016-03-09

    Magnetic skyrmions, which are topologically protected spin textures, are promising candidates for ultralow-energy and ultrahigh-density magnetic data storage and computing applications. To date, most experiments on skyrmions have been carried out at low temperatures. The choice of available materials is limited, and there is a lack of electrical means to control skyrmions in devices. In this work, we demonstrate a new method for creating a stable skyrmion bubble phase in the CoFeB–MgO material system at room temperature, by engineering the interfacial perpendicular magnetic anisotropy of the ferromagnetic layer. Importantly, we also demonstrate that artificially engineered symmetry breaking gives rise tomore » a force acting on the skyrmions, in addition to the current-induced spin–orbit torque, which can be used to drive their motion. This room-temperature creation and manipulation of skyrmions offers new possibilities to engineer skyrmionic devices. The results bring skyrmionic memory and logic concepts closer to realization in industrially relevant and manufacturable thin film material systems.« less

  13. Room-Temperature Creation and Spin–Orbit Torque Manipulation of Skyrmions in Thin Films with Engineered Asymmetry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yu, Guoqiang; Upadhyaya, Pramey; Li, Xiang

    2016-02-10

    Magnetic skyrmions, which are topologically protected spin textures, are promising candidates for ultralow-energy and ultrahigh-density magnetic data storage and computing applications. To date, most experiments on skyrmions have been carried out at low temperatures. The choice of available materials is limited, and there is a lack of electrical means to control skyrmions in devices. In this work, we demonstrate a new method for creating a stable skyrmion bubble phase in the CoFeB–MgO material system at room temperature, by engineering the interfacial perpendicular magnetic anisotropy of the ferromagnetic layer. Importantly, we also demonstrate that artificially engineered symmetry breaking gives rise tomore » a force acting on the skyrmions, in addition to the current-induced spin–orbit torque, which can be used to drive their motion. This room-temperature creation and manipulation of skyrmions offers new possibilities to engineer skyrmionic devices. The results bring skyrmionic memory and logic concepts closer to realization in industrially relevant and manufacturable thin film material systems.« less

  14. Controlling for Landform Age When Determining the Settlement History of the Kuril Islands

    PubMed Central

    MacInnes, Breanyn; Fitzhugh, Ben; Holman, Darryl

    2014-01-01

    Archaeological investigations of settlement patterns in dynamic landscapes can be strongly biased by the evolution of the Earth’s surface. The Kuril Island volcanic arc exemplifies such a dynamic landscape, where landscape-modifying geological forces were active during settlement, including sea-level changes, tectonic emergence, volcanic eruptive processes, coastal aggradation, and dune formation. With all these ongoing processes, in this paper we seek to understand how new landscape formation in the Holocene might bias archaeological interpretations of human settlement in the Kurils. Resolving this issue is fundamental to any interpretation of human settlement history derived from the distribution and age of archaeological sites from the region. On the basis of a comparison of landform ages and earliest archaeological occupation ages on those landforms, we conclude that landform creation did not significantly bias our aggregate archaeological evidence for earliest settlement. Some sections of the archipelago have larger proportions of landform creation dates closer to archaeological evidence of settlement and undoubtedly some archaeological sites have been lost to geomorphic processes. However, comparisons between regions reveal comparable archaeological establishment patterns irrespective of geomorphic antiquity. PMID:25684855

  15. Development of Matched (migratory Analytical Time Change Easy Detection) Method for Satellite-Tracked Migratory Birds

    NASA Astrophysics Data System (ADS)

    Doko, Tomoko; Chen, Wenbo; Higuchi, Hiroyoshi

    2016-06-01

    Satellite tracking technology has been used to reveal the migration patterns and flyways of migratory birds. In general, bird migration can be classified according to migration status. These statuses include the wintering period, spring migration, breeding period, and autumn migration. To determine the migration status, periods of these statuses should be individually determined, but there is no objective method to define 'a threshold date' for when an individual bird changes its status. The research objective is to develop an effective and objective method to determine threshold dates of migration status based on satellite-tracked data. The developed method was named the "MATCHED (Migratory Analytical Time Change Easy Detection) method". In order to demonstrate the method, data acquired from satellite-tracked Tundra Swans were used. MATCHED method is composed by six steps: 1) dataset preparation, 2) time frame creation, 3) automatic identification, 4) visualization of change points, 5) interpretation, and 6) manual correction. Accuracy was tested. In general, MATCHED method was proved powerful to identify the change points between migration status as well as stopovers. Nevertheless, identifying "exact" threshold dates is still challenging. Limitation and application of this method was discussed.

  16. The role of inter-comparisons in radiocarbon quality assurance

    NASA Astrophysics Data System (ADS)

    Scott, Marian; Cook, Gordon; Naysmith, Philip

    2016-04-01

    Radiocarbon dating is used widely in many geochronology projects as a basis for the creation and testing of chronological constructs. Radiocarbon measurements are by their nature complex and the degree of sample pre-treatment varies considerably depending on the material. Within the UK and Europe, there are a number of well-established laboratories and increasingly, scientists are not just commissioning new dates, but also using statistical modelling of assemblages of dates, perhaps measured in different laboratories, to provide formal date estimates for their investigations. The issue of comparability of measurements (and thus bias, accuracy and precision of measurement) from the diverse laboratories is one which has been the focus of some attention both within the 14C community and the wider user communities for some time. As a result of this but also as part of laboratory benchmarking and quality assurance, the 14C community has undertaken a wide-scale, far-reaching and evolving programme of inter-comparisons, to the benefit of laboratories and users alike. This paper presents the results from the most recent exercise SIRI. The objectives of SIRI included, through choice of material, to contribute to the discussion concerning laboratory offsets and error multipliers in the context of IntCal (the International Calibration Programme) and to gain a better understanding of differences in background derived from a range of infinite age material types.

  17. Do the exome: A case of Williams-Beuren syndrome with severe epilepsy due to a truncating de novo variant in GABRA1.

    PubMed

    Popp, Bernt; Trollmann, Regina; Büttner, Christian; Caliebe, Almuth; Thiel, Christian T; Hüffmeier, Ulrike; Reis, André; Zweier, Christiane

    2016-10-01

    Williams-Beuren syndrome (WBS) is a relatively common, clinically recognizable microdeletion syndrome. In most cases the typical heterozygous deletion of 1.5 Mb on chromosome 7q11.23 spanning about 26 genes can be identified. Also some larger or smaller atypical deletions have been reported and associated with additional or atypical phenotypic aspects. We report on an individual with typical WBS due to the common deletion and with refractory infantile spasms. Using trio-exome sequencing, we identified a de novo truncating variant c.1200del, p (Lys401Serfs*25) in GABRA1 as the likely cause of the early onset epilepsy. This unique case not only allows to further define the phenotypic spectrum of infantile epileptic encephalopathy associated with rare de novo GABRA1 variants but exemplifies the need for a sensitive review of unclear associations in clinically defined syndromes and for extended diagnostic work-up in individuals with unusual presentations of a genetically confirmed diagnosis. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  18. Verifying the new luminescence surface-exposure dating technique--rock falls in Canyonlands National Park, Utah

    NASA Astrophysics Data System (ADS)

    Pederson, J. L.; Sohbati, R.; Murray, A. S.; Jain, M.

    2015-12-01

    Recent studies have helped develop the optically stimulated luminescence (OSL) dating of rock surfaces, as applied to the age of the famous Great Gallery rock art panel in Canyonlands National Park. Chapot et al. (2012) dated a key rock fall to ~900 yrs ago by applying OSL to the outer 1-mm buried surface of a sandstone talus boulder, an age confirmed by independent radiocarbon dating. Later, in a novel approach and with the use of a local known-age calibration sample, Sohbati et al. (2012) modelled the millimeter-scale OSL-depth profile to determine a pre-burial exposure duration of ~700 years for the same rock fall. This combination of rock-fall dating and exposure dating--an approach with broad potential to date Holocene mass movements--constrains the creation of the Great Gallery rock art to a time window of 900 to ~1600 years ago (Pederson et al., 2014), a result met with some controversy. Here we report on a new phase of research to verify these results and further refine OSL-profile exposure dating for mass movements. New analyses from within and near the Great Gallery alcove include: i) exposure dating of the same alcove surface upon which the rock art is painted with a predicted exposure age of ~1600 years; ii) exposure dating of the top (light-exposed) side of the same rock-fall boulder whose buried side was previously dated to test for reproduction of the known age; and iii) an improved calibration sample from a nearby trail/road-cut for verification. The residual OSL signal is measured with depth in millimeter-thick increments of all samples. We first determine the site-specific luminescence reduction rate at the rock surface by fitting the OSL surface-exposure dating model to the calibration profile from the trail/road-cut. This parameterized model then provides exposure ages for the bleaching profiles observed in the other samples. Results have implications for the application of OSL rock-surface and exposure-profile dating in other settings where quartz-rich rock is available. We discuss how the light-exposed top and buried underside of clasts can be used in tandem for calibration. The technique has particular relevance to younger timescales over which cosmogenic nuclides are of limited application.

  19. Promoting public health legal preparedness for emergencies: review of current trends and their relevance in light of the Ebola crisis

    PubMed Central

    Cohen, Odeya; Feder-Bubis, Paula; Bar-Dayan, Yaron; Adini, Bruria

    2015-01-01

    Background Public health legal preparedness (PHLP) for emergencies is a core component of the health system response. However, the implementation of health legal preparedness differs between low- and middle-income countries (LMIC) and developed countries. Objective This paper examines recent trends regarding public health legal preparedness for emergencies and discusses its role in the recent Ebola outbreak. Design A rigorous literature review was conducted using eight electronic databases as well as Google Scholar. The results encompassed peer-reviewed English articles, reports, theses, and position papers dating from 2011 to 2014. Earlier articles concerning regulatory actions were also examined. Results The importance of PHLP has grown during the past decade and focuses mainly on infection–disease scenarios. Amid LMICs, it mostly refers to application of international regulations, whereas in developed states, it focuses on independent legislation and creation of conditions optimal to promoting an effective emergency management. Among developed countries, the United States’ utilisation of health legal preparedness is the most advanced, including the creation of a model comprising four elements: law, competencies, information, and coordination. Only limited research has been conducted in this field to date. Nevertheless, in both developed and developing states, studies that focused on regulations and laws activated in health systems during emergencies, identified inconsistency and incoherence. The Ebola outbreak plaguing West Africa since 2014 has global implications, challenges and paralleling results, that were identified in this review. Conclusions The review has shown the need to broaden international regulations, to deepen reciprocity between countries, and to consider LMICs health capacities, in order to strengthen the national health security. Adopting elements of the health legal preparedness model is recommended. PMID:26449204

  20. Promoting public health legal preparedness for emergencies: review of current trends and their relevance in light of the Ebola crisis.

    PubMed

    Cohen, Odeya; Feder-Bubis, Paula; Bar-Dayan, Yaron; Adini, Bruria

    2015-01-01

    Public health legal preparedness (PHLP) for emergencies is a core component of the health system response. However, the implementation of health legal preparedness differs between low- and middle-income countries (LMIC) and developed countries. This paper examines recent trends regarding public health legal preparedness for emergencies and discusses its role in the recent Ebola outbreak. A rigorous literature review was conducted using eight electronic databases as well as Google Scholar. The results encompassed peer-reviewed English articles, reports, theses, and position papers dating from 2011 to 2014. Earlier articles concerning regulatory actions were also examined. The importance of PHLP has grown during the past decade and focuses mainly on infection-disease scenarios. Amid LMICs, it mostly refers to application of international regulations, whereas in developed states, it focuses on independent legislation and creation of conditions optimal to promoting an effective emergency management. Among developed countries, the United States' utilisation of health legal preparedness is the most advanced, including the creation of a model comprising four elements: law, competencies, information, and coordination. Only limited research has been conducted in this field to date. Nevertheless, in both developed and developing states, studies that focused on regulations and laws activated in health systems during emergencies, identified inconsistency and incoherence. The Ebola outbreak plaguing West Africa since 2014 has global implications, challenges and paralleling results, that were identified in this review. The review has shown the need to broaden international regulations, to deepen reciprocity between countries, and to consider LMICs health capacities, in order to strengthen the national health security. Adopting elements of the health legal preparedness model is recommended.

  1. Predictors of successful use of a web-based healthcare document storage and sharing system for pediatric cancer survivors: Cancer SurvivorLink™.

    PubMed

    Williamson, Rebecca; Meacham, Lillian; Cherven, Brooke; Hassen-Schilling, Leann; Edwards, Paula; Palgon, Michael; Espinoza, Sofia; Mertens, Ann

    2014-09-01

    Cancer SurvivorLink™, www.cancersurvivorlink.org , is a patient-controlled communication tool where survivors can electronically store and share documents with healthcare providers. Functionally, SurvivorLink serves as an electronic personal health record-a record of health-related information managed and controlled by the survivor. Recruitment methods to increase registration and the characteristics of registrants who completed each step of using SurvivorLink are described. Pediatric cancer survivors were recruited via mailings, survivor clinic, and community events. Recruitment method and Aflac Survivor Clinic attendance was determined for each registrant. Registration date, registrant type (parent vs. survivor), zip code, creation of a personal health record in SurvivorLink, storage of documents, and document sharing were measured. Logistic regression was used to determine the characteristics that predicted creation of a health record and storage of documents. To date, 275 survivors/parents have completed registration: 63 were recruited via mailing, 99 from clinic, 56 from community events, and 57 via other methods. Overall, 66.9 % registrants created a personal health record and 45.7 % of those stored a health document. There were no significant predictors for creating a personal health record. Attending a survivor clinic was the strongest predictor of document storage (p < 0.01). Of those with a document stored, 21.4 % shared with a provider. Having attended survivor clinic is the biggest predictor of registering and using SurvivorLink. Many survivors must advocate for their survivorship care. Survivor Link provides educational material and supports the dissemination of survivor-specific follow-up recommendations to facilitate shared clinical care decision making.

  2. A comprehensive data processing plan for crop calendar MSS signature development from satellite imagery: Crop identification using vegetation phenology

    NASA Technical Reports Server (NTRS)

    Hlavka, C. A. (Principal Investigator); Carlyle, S. M.; Haralick, R. M.; Yokoyama, R.

    1978-01-01

    The author has identified the following significant results. The phenological method of crop identification involves the creation of crop signatures which characterize multispectral observations as phenological growth states. The phenological signature models spectral reflectance explicitly as a function of crop maturity rather than as a function of date. A correspondence of time to growth state is established which minimizes the smallest difference between the given multispectral multitemporal vector and a category mean vector. The application of the method to the identification of winter wheat and corn shows (1) the method is capable of discriminating crop type with about the same degree of accuracy as more traditional classifiers; (2) the use of LANDSAT observations on two or more dates yields better results than the use of a single observation; and (3) some potential is demonstrated for labeling the degree of maturity of the crop, as well as the crop type.

  3. Dating the growth of oceanic crust at a slow-spreading ridge

    USGS Publications Warehouse

    Schwartz, J.J.; John, Barbara E.; Cheadle, Michael J.; Miranda, E.A.; Grimes, Craig B.; Wooden, J.L.; Dick, H.J.B.

    2005-01-01

    Nineteen uranium-lead zircon ages of lower crustal gabbros from Atlantis Bank, Southwest Indian Ridge, constrain the growth and construction of oceanic crust at this slow-spreading midocean ridge. Approximately 75% of the gabbros accreted within error of the predicted seafloor magnetic age, whereas ???25% are significantly older. These anomalously old samples suggest either spatially varying stochastic intrusion at the ridge axis or, more likely, crystallization of older gabbros at depths of ???5 to 18 kilometers below the base of crust in the cold, axial lithosphere, which were uplifted and intruded by shallow-level magmas during the creation of Atlantis Bank.

  4. Protecting Dark Skies as a State-Wide Resource

    NASA Astrophysics Data System (ADS)

    Allen, Lori E.; Walker, Constance E.; Hall, Jeffrey C.; Larson, Steve; Williams, Grant; Falco, Emilio; Hinz, Joannah; Fortin, Pascal; Brocious, Dan; Corbally, Christopher; Gabor, Paul; Veillet, Christian; Shankland, Paul; Jannuzi, Buell; Cotera, Angela; Luginbuhl, Christian

    2018-01-01

    The state of Arizona contains the highest concentration of research telescopes in the continental United States, contributing more than a quarter of a billion dollars annually to the state's economy. Protecting the dark skies above these observatories is both good for astronomy and good for the state's economy. In this contribution we describe how a coalition of Arizona observatories is working together to protect our dark skies. Efforts date back to the creation of one of the first Outdoor Lighting Codes in the United States and continue today, including educational outreach, public policy engagement, and consensus building. We review some proven strategies, highlight recent successes and look at current threats.

  5. The origin of the grooves on Phobos

    NASA Technical Reports Server (NTRS)

    Thomas, P. C.; Veverka, J.; Duxbury, T.

    1977-01-01

    Various theories for the long, linear depressions on the surface of Phobos are reviewed. Imagery from Viking Orbiters is used to map the surface distribution of the grooves, study their morphology, and date them by means of the density of superimposed impact craters. Data is presented which tends to support the hypothesis that the deep-seated fracturing was caused by a large, nearly catastrophic cratering event. It is suggested that the grooves were produced during the creation of the Stickney crater, rather than as the result of tidal stresses induced by Mars or by drag forces during the hypothetical capture of the satellite by Mars.

  6. Adapting and using quality management methods to improve health promotion.

    PubMed

    Becker, Craig M; Glascoff, Mary A; Felts, William Michael; Kent, Christopher

    2015-01-01

    Although the western world is the most technologically advanced civilization to date, it is also the most addicted, obese, medicated, and in-debt adult population in history. Experts had predicted that the 21st century would be a time of better health and prosperity. Although wealth has increased, our quest to quell health problems using a pathogenic approach without understanding the interconnectedness of everyone and everything has damaged personal and planetary health. While current efforts help identify and eliminate causes of problems, they do not facilitate the creation of health and well-being as would be done with a salutogenic approach. Sociologist Aaron Antonovsky coined the term salutogenesis in 1979. It is derived from salus, which is Latin for health, and genesis, meaning to give birth. Salutogenesis, the study of the origins and creation of health, provides a method to identify an interconnected way to enhance well-being. Salutogenesis provides a framework for a method of practice to improve health promotion efforts. This article illustrates how quality management methods can be used to guide health promotion efforts focused on improving health beyond the absence of disease. Published by Elsevier Inc.

  7. Charles Darwin and the Origins of Plant Evolutionary Developmental Biology

    PubMed Central

    Friedman, William E.; Diggle, Pamela K.

    2011-01-01

    Much has been written of the early history of comparative embryology and its influence on the emergence of an evolutionary developmental perspective. However, this literature, which dates back nearly a century, has been focused on metazoans, without acknowledgment of the contributions of comparative plant morphologists to the creation of a developmental view of biodiversity. We trace the origin of comparative plant developmental morphology from its inception in the eighteenth century works of Wolff and Goethe, through the mid nineteenth century discoveries of the general principles of leaf and floral organ morphogenesis. Much like the stimulus that von Baer provided as a nonevolutionary comparative embryologist to the creation of an evolutionary developmental view of animals, the comparative developmental studies of plant morphologists were the basis for the first articulation of the concept that plant (namely floral) evolution results from successive modifications of ontogeny. Perhaps most surprisingly, we show that the first person to carefully read and internalize the remarkable advances in the understanding of plant morphogenesis in the 1840s and 1850s is none other than Charles Darwin, whose notebooks, correspondence, and (then) unpublished manuscripts clearly demonstrate that he had discovered the developmental basis for the evolutionary transformation of plant form. PMID:21515816

  8. Open Access to Geophysical Data

    NASA Astrophysics Data System (ADS)

    Sergeyeva, Nataliya A.; Zabarinskaya, Ludmila P.

    2017-04-01

    Russian World Data Centers for Solar-Terrestrial Physics & Solid Earth Physics hosted by the Geophysical Center of the Russian Academy of Sciences are the Regular Members of the ICSU-World Data System. Guided by the principles of the WDS Constitution and WDS Data Sharing Principles, the WDCs provide full and open access to data, long-term data stewardship, compliance with agreed-upon data standards and conventions, and mechanisms to facilitate and improve access to data. Historical and current geophysical data on different media, in the form of digital data sets, analog records, collections of maps, descriptions are stored and collected in the Centers. The WDCs regularly fill up repositories and database with new data, support them up to date. Now the WDCs focus on four new projects, aimed at increase of data available in network by retrospective data collection and digital preservation of data; creation of a modern system of registration and publication of data with digital object identifier (DOI) assignment, and promotion of data citation culture; creation of databases instead of file system for more convenient access to data; participation in the WDS Metadata Catalogue and Data Portal by creating of metadata for information resources of WDCs.

  9. Charles Darwin and the origins of plant evolutionary developmental biology.

    PubMed

    Friedman, William E; Diggle, Pamela K

    2011-04-01

    Much has been written of the early history of comparative embryology and its influence on the emergence of an evolutionary developmental perspective. However, this literature, which dates back nearly a century, has been focused on metazoans, without acknowledgment of the contributions of comparative plant morphologists to the creation of a developmental view of biodiversity. We trace the origin of comparative plant developmental morphology from its inception in the eighteenth century works of Wolff and Goethe, through the mid nineteenth century discoveries of the general principles of leaf and floral organ morphogenesis. Much like the stimulus that von Baer provided as a nonevolutionary comparative embryologist to the creation of an evolutionary developmental view of animals, the comparative developmental studies of plant morphologists were the basis for the first articulation of the concept that plant (namely floral) evolution results from successive modifications of ontogeny. Perhaps most surprisingly, we show that the first person to carefully read and internalize the remarkable advances in the understanding of plant morphogenesis in the 1840s and 1850s is none other than Charles Darwin, whose notebooks, correspondence, and (then) unpublished manuscripts clearly demonstrate that he had discovered the developmental basis for the evolutionary transformation of plant form.

  10. LOVD: easy creation of a locus-specific sequence variation database using an "LSDB-in-a-box" approach.

    PubMed

    Fokkema, Ivo F A C; den Dunnen, Johan T; Taschner, Peter E M

    2005-08-01

    The completion of the human genome project has initiated, as well as provided the basis for, the collection and study of all sequence variation between individuals. Direct access to up-to-date information on sequence variation is currently provided most efficiently through web-based, gene-centered, locus-specific databases (LSDBs). We have developed the Leiden Open (source) Variation Database (LOVD) software approaching the "LSDB-in-a-Box" idea for the easy creation and maintenance of a fully web-based gene sequence variation database. LOVD is platform-independent and uses PHP and MySQL open source software only. The basic gene-centered and modular design of the database follows the recommendations of the Human Genome Variation Society (HGVS) and focuses on the collection and display of DNA sequence variations. With minimal effort, the LOVD platform is extendable with clinical data. The open set-up should both facilitate and promote functional extension with scripts written by the community. The LOVD software is freely available from the Leiden Muscular Dystrophy pages (www.DMD.nl/LOVD/). To promote the use of LOVD, we currently offer curators the possibility to set up an LSDB on our Leiden server. (c) 2005 Wiley-Liss, Inc.

  11. New lessons learned from disease modeling with induced Pluripotent Stem Cells

    PubMed Central

    Onder, Tamer T.; Daley, George Q.

    2012-01-01

    Cellular reprogramming and generation of induced pluripotent stem cells (iPSCs) from adult cell types has enabled the creation of patient-specific stem cells for use in disease modeling. To date, many iPSC lines have been generated from a variety of disorders, which have then been differentiated into disease-relevant cell types. When a disease-specific phenotype is detectable in such differentiated cells, the reprogramming technology provides a new opportunity to identify aberrant disease-associated pathways and drugs that can block them. Here, we highlight recent progress as well as limitations in the use of iPSCs to recapitulate disease phenotypes and to screen for therapeutics in vitro. PMID:22749051

  12. Mutation analysis of the MYO7A and CDH23 genes in Japanese patients with Usher syndrome type 1.

    PubMed

    Nakanishi, Hiroshi; Ohtsubo, Masafumi; Iwasaki, Satoshi; Hotta, Yoshihiro; Takizawa, Yoshinori; Hosono, Katsuhiro; Mizuta, Kunihiro; Mineta, Hiroyuki; Minoshima, Shinsei

    2010-12-01

    Usher syndrome (USH) is an autosomal recessive disorder characterized by retinitis pigmentosa and hearing loss. USH type 1 (USH1), the second common type of USH, is frequently caused by MYO7A and CDH23 mutations, accounting for 70-80% of the cases among various ethnicities, including Caucasians, Africans and Asians. However, there have been no reports of mutation analysis for any responsible genes for USH1 in Japanese patients. This study describes the first mutation analysis of MYO7A and CDH23 in Japanese USH1 patients. Five mutations (three in MYO7A and two in CDH23) were identified in four of five unrelated patients. Of these mutations, two were novel. One of them, p.Tyr1942SerfsX23 in CDH23, was a large deletion causing the loss of 3 exons. This is the first large deletion to be found in CDH23. The incidence of the MYO7A and CDH23 mutations in the study population was 80%, which is consistent with previous findings. Therefore, mutation screening for these genes is expected to be a highly sensitive method for diagnosing USH1 among the Japanese.

  13. Birt-Hogg-Dubé syndrome: novel FLCN frameshift deletion in daughter and father with renal cell carcinomas.

    PubMed

    Näf, Ernst; Laubscher, Dominik; Hopfer, Helmut; Streit, Markus; Matyas, Gabor

    2016-01-01

    Germline mutation of the FLCN gene causes Birt-Hogg-Dubé syndrome (BHD), a rare autosomal dominant condition characterized by skin fibrofolliculomas, lung cysts, spontaneous pneumothorax and renal tumours. We identified a hitherto unreported pathogenic FLCN frameshift deletion c.563delT (p.Phe188Serfs*35) in a family of a 46-year-old woman presented with macrohematuria due to bilateral chromophobe renal carcinomas. A heritable renal cancer was suspected due to the bilaterality of the tumour and as the father of this woman had suffered from renal cancer. Initially, however, BHD was overlooked by the medical team despite the highly suggestive clinical presentation. We assume that BHD is underdiagnosed, at least partially, due to low awareness of this variable condition and to insufficient use of appropriate genetic testing. Our study indicates that BHD and FLCN testing should be routinely considered in patients with positive family or personal history of renal tumours. In addition, we demonstrate how patients and their families can play a driving role in initiating genetic diagnosis, presymptomatic testing of at-risk relatives, targeted disease management, and genetic counselling of rare diseases such as BHD.

  14. Measurement Sensitivity Improvement of All-Optical Atomic Spin Magnetometer by Suppressing Noises

    PubMed Central

    Chen, Xiyuan; Zhang, Hong; Zou, Sheng

    2016-01-01

    Quantum manipulation technology and photoelectric detection technology have jointly facilitated the rapid development of ultra-sensitive atomic spin magnetometers. To improve the output signal and sensitivity of the spin-exchange-relaxation-free (SERF) atomic spin magnetometer, the noises influencing on the output signal and the sensitivity were analyzed, and the corresponding noise suppression methods were presented. The magnetic field noises, including the residual magnetic field noise and the light shift noise, were reduced to approximately zero by employing the magnetic field compensation method and by adjusting the frequency of the pump beam, respectively. With respect to the operation temperature, the simulation results showed that the temperature of the potassium atomic spin magnetometer realizing the spin-exchange relaxation-free regime was 180 °C. Moreover, the fluctuation noises of the frequency and the power were suppressed by using the frequency and the power stable systems. The experimental power stability results showed that the light intensity stability was enhanced 10%. Contrast experiments on the sensitivity were carried out to demonstrate the validity of the suppression methods. Finally, a sensitivity of 13 fT/Hz1/2 was successfully achieved by suppressing noises and optimizing parameters. PMID:27322272

  15. Hypomorphic Temperature-Sensitive Alleles of NSDHL Cause CK Syndrome

    PubMed Central

    McLarren, Keith W.; Severson, Tesa M.; du Souich, Christèle; Stockton, David W.; Kratz, Lisa E.; Cunningham, David; Hendson, Glenda; Morin, Ryan D.; Wu, Diane; Paul, Jessica E.; An, Jianghong; Nelson, Tanya N.; Chou, Athena; DeBarber, Andrea E.; Merkens, Louise S.; Michaud, Jacques L.; Waters, Paula J.; Yin, Jingyi; McGillivray, Barbara; Demos, Michelle; Rouleau, Guy A.; Grzeschik, Karl-Heinz; Smith, Raffaella; Tarpey, Patrick S.; Shears, Debbie; Schwartz, Charles E.; Gecz, Jozef; Stratton, Michael R.; Arbour, Laura; Hurlburt, Jane; Van Allen, Margot I.; Herman, Gail E.; Zhao, Yongjun; Moore, Richard; Kelley, Richard I.; Jones, Steven J.M.; Steiner, Robert D.; Raymond, F. Lucy; Marra, Marco A.; Boerkoel, Cornelius F.

    2010-01-01

    CK syndrome (CKS) is an X-linked recessive intellectual disability syndrome characterized by dysmorphism, cortical brain malformations, and an asthenic build. Through an X chromosome single-nucleotide variant scan in the first reported family, we identified linkage to a 5 Mb region on Xq28. Sequencing of this region detected a segregating 3 bp deletion (c.696_698del [p.Lys232del]) in exon 7 of NAD(P) dependent steroid dehydrogenase-like (NSDHL), a gene that encodes an enzyme in the cholesterol biosynthesis pathway. We also found that males with intellectual disability in another reported family with an NSDHL mutation (c.1098 dup [p.Arg367SerfsX33]) have CKS. These two mutations, which alter protein folding, show temperature-sensitive protein stability and complementation in Erg26-deficient yeast. As described for the allelic disorder CHILD syndrome, cells and cerebrospinal fluid from CKS patients have increased methyl sterol levels. We hypothesize that methyl sterol accumulation, not only cholesterol deficiency, causes CKS, given that cerebrospinal fluid cholesterol, plasma cholesterol, and plasma 24S-hydroxycholesterol levels are normal in males with CKS. In summary, CKS expands the spectrum of cholesterol-related disorders and insight into the role of cholesterol in human development. PMID:21129721

  16. The ClearEarth Project: Preliminary Findings from Experiments in Applying the CLEARTK NLP Pipeline and Annotation Tools Developed for Biomedicine to the Earth Sciences

    NASA Astrophysics Data System (ADS)

    Duerr, R.; Thessen, A.; Jenkins, C. J.; Palmer, M.; Myers, S.; Ramdeen, S.

    2016-12-01

    The ability to quickly find, easily use and effortlessly integrate data from a variety of sources is a grand challenge in Earth sciences, one around which entire research programs have been built. A myriad of approaches to tackling components of this challenge have been demonstrated, often with some success. Yet finding, assessing, accessing, using and integrating data remains a major challenge for many researchers. A technology that has shown promise in nearly every aspect of the challenge is semantics. Semantics has been shown to improve data discovery, facilitate assessment of a data set, and through adoption of the W3C's Linked Data Platform to have improved data integration and use at least for data amenable to that paradigm. Yet the creation of semantic resources has been slow. Why? Amongst a plethora of other reasons, it is because semantic expertise is rare in the Earth and Space sciences; the creation of semantic resources for even a single discipline is labor intensive and requires agreement within the discipline; best practices, methods and tools for supporting the creation and maintenance of the resources generated are in flux; and the human and financial capital needed are rarely available in the Earth sciences. However, other fields, such as biomedicine, have made considerable progress in these areas. The NSF-funded ClearEarth project is adapting the methods and tools from these communities for the Earth sciences in the expectation that doing so will enhance progress and the rate at which the needed semantic resources are created. We discuss progress and results to date, lessons learned from this adaptation process, and describe our upcoming efforts to extend this knowledge to the next generation of Earth and data scientists.

  17. Geoarchaeology, the four dimensional (4D) fluvial matrix and climatic causality

    NASA Astrophysics Data System (ADS)

    Brown, A. G.

    2008-10-01

    Geoarchaeology is the application of geological and geomorphological techniques to archaeology and the study of the interactions of hominins with the natural environment at a variety of temporal and spatial scales. Geoarchaeology in the UK over the last twenty years has flourished largely because it has gone beyond technological and scientific applications. Over the same period our ability to reconstruct the 3-dimensional stratigraphy of fluvial deposits and the matrix of fluvial sites has increased dramatically because of a number of technological advances. These have included the use of LiDAR (laser imaging) and radar to produce high-resolution digital surface models, the use of geophysics, particularly ground penetrating radar and electrical resistivity, to produce sediment depth models, and the use of GIS and data visualisation techniques to manipulate and display the data. These techniques along with more systematic and detailed sedimentological recording of exposed sections have allowed the construction of more precise 3-dimensional (volumetric) models of the matrix of artefacts within fluvial deposits. Additionally a revolution in dating techniques, particularly direct sediment dating by luminescence methods, has enabled the creation of 4-dimensional models of the creation and preservation of these sites. These 4-dimensional models have the ability to provide far more information about the processes of site creation, preservation and even destruction, and also allow the integration of these processes with independent data sources concerning cultural evolution and climatic change. All improvements in the precision of dating fluvial deposits have archaeological importance in our need to translate events from a sequential or geological timeframe to human timescales. This allows geoarchaeology to make a more direct contribution to cultural history through the recognition of agency at the individual or group level. This data can then form a component of biocomplexity or agent-based modelling which is becoming increasingly used in the natural sciences, particularly ecology and geomorphology and which can be used to test scenarios including the impact on, and response of, hominins to abrupt or catastrophic environmental change. Whilst catastrophic events clearly represent the atypical they can be illuminating in revealing cognitive processes resulting in abandonment, coping, mitigation and innovation. These points are exemplified using two in-depth case studies: one from the Holocene geoarchaeological record of the River Trent in Central England and the other from the Palaeolithic record from rivers in South West Britain. In the former the interaction between climate change and human activity is illustrated at the year to century timescale whilst in the other the timescale is millennial. These case studies have deliberately been chosen to be as different as possible in temporal and spatial scale with the aim of examining the applicability of methodological and theoretical aspects of geoarchaeology. Lastly the paper considers the problem of scale in geoarchaeology and concludes it is process-dependency, which ultimately affects the questions we can ask, and that questions of human response to climate change are fundamentally a product of materiality and cognitive processes. This demands an in-depth contextual approach to such questions rather than database-driven assertions of causality.

  18. Diamond nanowires: fabrication, structure, properties, and applications.

    PubMed

    Yu, Yuan; Wu, Liangzhuan; Zhi, Jinfang

    2014-12-22

    C(sp(3) )C-bonded diamond nanowires are wide band gap semiconductors that exhibit a combination of superior properties such as negative electron affinity, chemical inertness, high Young's modulus, the highest hardness, and room-temperature thermal conductivity. The creation of 1D diamond nanowires with their giant surface-to-volume ratio enhancements makes it possible to control and enhance the fundamental properties of diamond. Although theoretical comparisons with carbon nanotubes have shown that diamond nanowires are energetically and mechanically viable structures, reproducibly synthesizing the crystalline diamond nanowires has remained challenging. We present a comprehensive, up-to-date review of diamond nanowires, including a discussion of their synthesis along with their structures, properties, and applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Probing transplant and living donor candidates about their participation in organ vending.

    PubMed

    Bramstedt, Katrina A

    2010-09-01

    The selling of human organs for transplant is illegal in the United States and in most countries; however, such transactions still occur. Transplant hospitals and their personnel have multiple ethical duties, including (1) protecting the safety of their living donors and transplant recipients and (2) protecting the integrity of living donation and transplantation as clinical practices. To date, few psychosocial screening tools exist that pertain specifically to a person's risk or intent of pursuing organ vending (buying or selling). This article presents a series of transplant ethics case consultations that spawned the creation of a set of behavioral prompts for teams to probe with regard to organ vending when screening candidates about their suitability for participation as living donors or transplant recipients.

  20. Successful combination of electron spin resonance, luminescence and palaeomagnetic dating methods allows reconstruction of the Pleistocene evolution of the lower Moulouya river (NE Morocco)

    NASA Astrophysics Data System (ADS)

    Bartz, Melanie; Rixhon, Gilles; Duval, Mathieu; King, Georgina E.; Álvarez Posada, Claudia; Parés, Josep M.; Brückner, Helmut

    2018-04-01

    Based on a combination of Electron Spin Resonance (ESR) dating of quartz, luminescence dating of K-feldspar and palaeomagnetism, this study presents the first chronostratigraphic framework for the Pleistocene fluvial deposits of the lower Moulouya river in the Triffa basin (NE Morocco). K-feldspar pIRIR225 and pIRIR290 signals of all samples are saturated, suggesting fluvial deposition at least as early as the Middle Pleistocene (∼0.39-0.80 Ma). Consequently, further chronological information was obtained with ESR dating of quartz grains from the ancient Pleistocene fluvial deposits. As for ESR, the multiple centres approach provides equivalent dose values derived from the Al and Ti centres that mostly agree within 1σ-error, suggesting complete signal resetting from the former during fluvial transport. ESR dating results yield Calabrian deposition ages for all river profiles from ∼1.1 to ∼1.5 Ma. These ages are remarkably consistent with the palaeomagnetic results: the occurrence of mostly reversed polarity in the deposits indicates a Matuyama age (>0.78 Ma). While low incision rates in the Triffa basin (0.025 ± 0.003 mm/a) related to thrusting activity during the Calabrian could be inferred, the fluvial record points to an acyclic and discontinuous sedimentation pattern over the last ∼1.3 Ma. It thereby probably rules out climate as the main driver for fluvial aggradation in the lowermost sedimentary basin. At a regional scale, several indicators point to transient fluvial response resulting from major Quaternary tectonic activity along the Beni Snassen gorge, located directly upstream of the investigated basin. We suggest that a capture event at the margin of the uplifting Beni Snassen massif occurred between 1.04 and 1.36 Ma at the latest and subsequently led to the creation of the gorge.

  1. sCO2 Brayton Cycle: Roadmap to sCO2 Power Cycles NE Commercial Applications.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mendez Cruz, Carmen Margarita; Rochau, Gary E.

    The mission of the Energy Conversion (EC) area of the Advanced Reactor Technology (ART) program is to commercialize the sCO2 Brayton cycle for Advance Reactors and for the Supercritical Transformational Electric Production (STEP) program. The near-term objective of the EC team efforts is to support the development of a commercially scalable Recompression Closed Brayton Cycle (RCBC) to be constructed for the first STEP demonstration system with the lowest risk possible. This document details the status of technology, policy and market considerations, documentation of gaps and needs, and outlines the steps necessary for the successful development and deployment of commercial sCO2more » Brayton Power Systems along the path to nuclear reactor applications. Document Control Version Creation Date Revisions Created By Release Date 1.0 2/29/2016 Preliminary Draft Mendez, C. 3/2/2016 2.0 7/29/2016 Preliminaty/Partial Report -- updated Focus Area structure, added commercial path forward Mendez, C. 8/10/16 3.0 5/1/2018 Updated Roadmap supports timeline changes and inclusion of grid qualification goals Mendez, C. 6/6/18« less

  2. Hypomorphic temperature-sensitive alleles of NSDHL cause CK syndrome.

    PubMed

    McLarren, Keith W; Severson, Tesa M; du Souich, Christèle; Stockton, David W; Kratz, Lisa E; Cunningham, David; Hendson, Glenda; Morin, Ryan D; Wu, Diane; Paul, Jessica E; An, Jianghong; Nelson, Tanya N; Chou, Athena; DeBarber, Andrea E; Merkens, Louise S; Michaud, Jacques L; Waters, Paula J; Yin, Jingyi; McGillivray, Barbara; Demos, Michelle; Rouleau, Guy A; Grzeschik, Karl-Heinz; Smith, Raffaella; Tarpey, Patrick S; Shears, Debbie; Schwartz, Charles E; Gecz, Jozef; Stratton, Michael R; Arbour, Laura; Hurlburt, Jane; Van Allen, Margot I; Herman, Gail E; Zhao, Yongjun; Moore, Richard; Kelley, Richard I; Jones, Steven J M; Steiner, Robert D; Raymond, F Lucy; Marra, Marco A; Boerkoel, Cornelius F

    2010-12-10

    CK syndrome (CKS) is an X-linked recessive intellectual disability syndrome characterized by dysmorphism, cortical brain malformations, and an asthenic build. Through an X chromosome single-nucleotide variant scan in the first reported family, we identified linkage to a 5 Mb region on Xq28. Sequencing of this region detected a segregating 3 bp deletion (c.696_698del [p.Lys232del]) in exon 7 of NAD(P) dependent steroid dehydrogenase-like (NSDHL), a gene that encodes an enzyme in the cholesterol biosynthesis pathway. We also found that males with intellectual disability in another reported family with an NSDHL mutation (c.1098 dup [p.Arg367SerfsX33]) have CKS. These two mutations, which alter protein folding, show temperature-sensitive protein stability and complementation in Erg26-deficient yeast. As described for the allelic disorder CHILD syndrome, cells and cerebrospinal fluid from CKS patients have increased methyl sterol levels. We hypothesize that methyl sterol accumulation, not only cholesterol deficiency, causes CKS, given that cerebrospinal fluid cholesterol, plasma cholesterol, and plasma 24S-hydroxycholesterol levels are normal in males with CKS. In summary, CKS expands the spectrum of cholesterol-related disorders and insight into the role of cholesterol in human development. Copyright © 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  3. Ultra-sensitive magnetic microscopy with an optically pumped magnetometer

    DOE PAGES

    Kim, Young Jin; Savukov, Igor Mykhaylovich

    2016-04-22

    Optically pumped magnetometers (OPMs) based on lasers and alkali-metal vapor cells are currently the most sensitive non-cryogenic magnetic field sensors. Many applications in neuroscience and other fields require high-resolution, high-sensitivity magnetic microscopic measurements. In order to meet this demand we combined a cm-size spin-exchange relaxation-free (SERF) OPM and flux guides (FGs) to realize an ultra-sensitive FG-OPM magnetic microscope. The FGs serve to transmit the target magnetic flux to the OPM thus improving both the resolution and sensitivity to small magnetic objects. We investigated the performance of the FG-OPM device using experimental and numerical methods, and demonstrated that an optimized devicemore » can achieve a unique combination of high resolution (80 μm) and high sensitivity (8.1 pT/). Additionally, we also performed numerical calculations of the magnetic field distribution in the FGs to estimate the magnetic noise originating from the domain fluctuations in the material of the FGs. We anticipate many applications of the FG-OPM device such as the detection of micro-biological magnetic fields; the detection of magnetic nano-particles; and non-destructive testing. From our theoretical estimate, an FG-OPM could detect the magnetic field of a single neuron, which would be an important milestone in neuroscience.« less

  4. A novel ABCD1 mutation detected by next generation sequencing in presumed hereditary spastic paraplegia: A 30-year diagnostic delay caused by misleading biochemical findings.

    PubMed

    Koutsis, Georgios; Lynch, David S; Tucci, Arianna; Houlden, Henry; Karadima, Georgia; Panas, Marios

    2015-08-15

    To present a Greek family in which 5 male and 2 female members developed progressive spastic paraplegia. Plasma very long chain fatty acids (VLCFA) were reportedly normal at first testing in an affected male and for over 30 years the presumed diagnosis was hereditary spastic paraplegia (HSP). Targeted next generation sequencing (NGS) was used as a further diagnostic tool. Targeted exome sequencing in the proband, followed by Sanger sequencing confirmation; mutation segregation testing in multiple family members and plasma VLCFA measurement in the proband. NGS of the proband revealed a novel frameshift mutation in ABCD1 (c.1174_1178del, p.Leu392Serfs*7), bringing an end to diagnostic uncertainty by establishing the diagnosis of adrenomyeloneuropathy (AMN), the myelopathic phenotype of X-linked adrenoleukodystrophy (ALD). The mutation segregated in all family members and the diagnosis of AMN/ALD was confirmed by plasma VLCFA measurement. Confounding factors that delayed the diagnosis are presented. This report highlights the diagnostic utility of NGS in patients with undiagnosed spastic paraplegia, establishing a molecular diagnosis of AMN, allowing proper genetic counseling and management, and overcoming the diagnostic delay that can be rarely caused by false negative VLCFA analysis. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Ultra-sensitive Magnetic Microscopy with an Optically Pumped Magnetometer

    NASA Astrophysics Data System (ADS)

    Kim, Young Jin; Savukov, Igor

    2016-04-01

    Optically pumped magnetometers (OPMs) based on lasers and alkali-metal vapor cells are currently the most sensitive non-cryogenic magnetic field sensors. Many applications in neuroscience and other fields require high-resolution, high-sensitivity magnetic microscopic measurements. In order to meet this demand we combined a cm-size spin-exchange relaxation-free (SERF) OPM and flux guides (FGs) to realize an ultra-sensitive FG-OPM magnetic microscope. The FGs serve to transmit the target magnetic flux to the OPM thus improving both the resolution and sensitivity to small magnetic objects. We investigated the performance of the FG-OPM device using experimental and numerical methods, and demonstrated that an optimized device can achieve a unique combination of high resolution (80 μm) and high sensitivity (8.1 pT/). In addition, we also performed numerical calculations of the magnetic field distribution in the FGs to estimate the magnetic noise originating from the domain fluctuations in the material of the FGs. We anticipate many applications of the FG-OPM device such as the detection of micro-biological magnetic fields; the detection of magnetic nano-particles; and non-destructive testing. From our theoretical estimate, an FG-OPM could detect the magnetic field of a single neuron, which would be an important milestone in neuroscience.

  6. Ultra-sensitive magnetic microscopy with an optically pumped magnetometer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Young Jin; Savukov, Igor Mykhaylovich

    Optically pumped magnetometers (OPMs) based on lasers and alkali-metal vapor cells are currently the most sensitive non-cryogenic magnetic field sensors. Many applications in neuroscience and other fields require high-resolution, high-sensitivity magnetic microscopic measurements. In order to meet this demand we combined a cm-size spin-exchange relaxation-free (SERF) OPM and flux guides (FGs) to realize an ultra-sensitive FG-OPM magnetic microscope. The FGs serve to transmit the target magnetic flux to the OPM thus improving both the resolution and sensitivity to small magnetic objects. We investigated the performance of the FG-OPM device using experimental and numerical methods, and demonstrated that an optimized devicemore » can achieve a unique combination of high resolution (80 μm) and high sensitivity (8.1 pT/). Additionally, we also performed numerical calculations of the magnetic field distribution in the FGs to estimate the magnetic noise originating from the domain fluctuations in the material of the FGs. We anticipate many applications of the FG-OPM device such as the detection of micro-biological magnetic fields; the detection of magnetic nano-particles; and non-destructive testing. From our theoretical estimate, an FG-OPM could detect the magnetic field of a single neuron, which would be an important milestone in neuroscience.« less

  7. Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains.

    PubMed

    Lewis, Tony E; Sillitoe, Ian; Andreeva, Antonina; Blundell, Tom L; Buchan, Daniel W A; Chothia, Cyrus; Cuff, Alison; Dana, Jose M; Filippis, Ioannis; Gough, Julian; Hunter, Sarah; Jones, David T; Kelley, Lawrence A; Kleywegt, Gerard J; Minneci, Federico; Mitchell, Alex; Murzin, Alexey G; Ochoa-Montaño, Bernardo; Rackham, Owen J L; Smith, James; Sternberg, Michael J E; Velankar, Sameer; Yeats, Corin; Orengo, Christine

    2013-01-01

    Genome3D, available at http://www.genome3d.eu, is a new collaborative project that integrates UK-based structural resources to provide a unique perspective on sequence-structure-function relationships. Leading structure prediction resources (DomSerf, FUGUE, Gene3D, pDomTHREADER, Phyre and SUPERFAMILY) provide annotations for UniProt sequences to indicate the locations of structural domains (structural annotations) and their 3D structures (structural models). Structural annotations and 3D model predictions are currently available for three model genomes (Homo sapiens, E. coli and baker's yeast), and the project will extend to other genomes in the near future. As these resources exploit different strategies for predicting structures, the main aim of Genome3D is to enable comparisons between all the resources so that biologists can see where predictions agree and are therefore more trusted. Furthermore, as these methods differ in whether they build their predictions using CATH or SCOP, Genome3D also contains the first official mapping between these two databases. This has identified pairs of similar superfamilies from the two resources at various degrees of consensus (532 bronze pairs, 527 silver pairs and 370 gold pairs).

  8. f-treeGC: a questionnaire-based family tree-creation software for genetic counseling and genome cohort studies.

    PubMed

    Tokutomi, Tomoharu; Fukushima, Akimune; Yamamoto, Kayono; Bansho, Yasushi; Hachiya, Tsuyoshi; Shimizu, Atsushi

    2017-07-14

    The Tohoku Medical Megabank project aims to create a next-generation personalized healthcare system by conducting large-scale genome-cohort studies involving three generations of local residents in the areas affected by the Great East Japan Earthquake. We collected medical and genomic information for developing a biobank to be used for this healthcare system. We designed a questionnaire-based pedigree-creation software program named "f-treeGC," which enables even less experienced medical practitioners to accurately and rapidly collect family health history and create pedigree charts. f-treeGC may be run on Adobe AIR. Pedigree charts are created in the following manner: 1) At system startup, the client is prompted to provide required information on the presence or absence of children; f-treeGC is capable of creating a pedigree up to three generations. 2) An interviewer fills out a multiple-choice questionnaire on genealogical information. 3) The information requested includes name, age, gender, general status, infertility status, pregnancy status, fetal status, and physical features or health conditions of individuals over three generations. In addition, information regarding the client and the proband, and birth order information, including multiple gestation, custody, multiple individuals, donor or surrogate, adoption, and consanguinity may be included. 4) f-treeGC shows only marriages between first cousins via the overlay function. 5) f-treeGC automatically creates a pedigree chart, and the chart-creation process is visible for inspection on the screen in real time. 6) The genealogical data may be saved as a file in the original format. The created/modified date and time may be changed as required, and the file may be password-protected and/or saved in read-only format. To enable sorting or searching from the database, the file name automatically contains the terms typed into the entry fields, including physical features or health conditions, by default. 7) Alternatively, family histories are collected using a completed foldable interview paper sheet named "f-sheet", which is identical to the questionnaire in f-treeGC. We developed a questionnaire-based family tree-creation software, named f-treeGC, which is fully compliant with international recommendations for standardized human pedigree nomenclature. The present software simplifies the process of collecting family histories and pedigrees, and has a variety of uses, from genome cohort studies or primary care to genetic counseling.

  9. Creationism as Science: What Every Teacher-Scientist Should Know.

    ERIC Educational Resources Information Center

    Gatzke, Ken W.

    1985-01-01

    Addresses philosophical problems of the evolution/creationism debate (including underlying assumptions of creationism and nature of science), suggesting that creationism cannot be presented as science in science courses because it fails to qualify as a science. Prediction and explanation, absolute creationism, and a fundamental difficulty in…

  10. [The creation of a new nutritional market in Spain: vitamins in the press (1917-1950)].

    PubMed

    Perdiguero-Gil, E

    2012-11-01

    To analyze the extent to which vitamins played a role in the strategy to create a new market of food, food-medicines, and medicines in Spain during the first half of the twentieth century. A study was made of references to vitamins in the years between 1917 and 1950 in the daily newspapers "ABC", "Heraldo de Madrid", "El Imparcial", "El Liberal" and "El Sol", published in Madrid, "La Vanguardia", published in Barcelona, and the weekly publication "Blanco y Negro". The starting date was selected as the year in which the first news of vitamins appeared. The year 1950 marked the end of the harshest stage of autarky imposed by Franco's regime. The news that appeared was classified in the following categories: scientific news, nutritional advice, advertising, economy, politics, anecdotes and metaphors. The advertisements that used vitamins as part of their marketing strategy are the most important section with over 50% of total references to the vitamin concept in almost all the newspapers. Scientific news on vitamins ranks second in importance. References to vitamins in the remaining categories were below 5%. Judging by the references which appear in the most important newspapers of the time vitamins represent a fundamental element in the creation of a new food product market in Spain in the first half of the twentieth century.

  11. The coming technological singularity: How to survive in the post-human era

    NASA Technical Reports Server (NTRS)

    Vinge, Vernor

    1993-01-01

    The acceleration of technological progress has been the central feature of this century. I argue in this paper that we are on the edge of change comparable to the rise of human life on Earth. The precise cause of this change is the imminent creation by technology of entities with greater than human intelligence. There are several means by which science may achieve this breakthrough (and this is another reason for having confidence that the event will occur): (1) the development of computers that are 'awake' and superhumanly intelligent (to date, most controversy in the area of AI relates to whether we can create human equivalence in a machine. But if the answer is 'yes, we can', then there is little doubt that beings more intelligent can be constructed shortly thereafter); (2) large computer networks (and their associated users) may 'wake up' as a superhumanly intelligent entity; (3) computer/human interfaces may become so intimate that users may reasonably be considered superhumanly intelligent; and (4) biological science may find ways to improve upon the natural human intellect. The first three possibilities depend in large part on improvements in computer hardware. Progress in computer hardware has followed an amazingly steady curve in the last few decades. Based largely on this trend, I believe that the creation of greater than human intelligence will occur during the next thirty years.

  12. Vulnerability of Space Station Freedom Modules: A Study of the Effects of Module Perforation on Crew and Equipment. Volume 2; Analytical Modeling of Internal Debris Cloud Effects

    NASA Technical Reports Server (NTRS)

    Schonberg, William P.; Davenport, Quint

    1995-01-01

    In this part of the report, a first-principles based model is developed to predict the overpressure and temperature effects of a perforating orbital debris particle impact within a pressurized habitable module. While the effects of a perforating debris particles on crew and equipment can be severe, only a limited number of empirical studies focusing on space vehicles have been performed to date. Traditionally, crew loss or incapacitation due to a perforating impact has primarily been of interest to military organizations and as such have focused on military vehicles and systems. The module wall considered in this study is initially assumed to be a standard Whippletype dual-wall system in which the outer wall protects the module and its inhabitants by disrupting impacting particles. The model is developed in a way such that it sequentially characterizes the phenomena comprising the impact event, including the initial impact, the creation and motion of a debris cloud within the dual-wall system, the impact of the debris cloud on the inner wall, the creation and motion of the debris cloud that enters the module interior, and the effects of the debris cloud within the module on module pressure and temperature levels. This is accomplished through the application of elementary shock physics and thermodynamic theory.

  13. Cancer vaccines inducing antibody production: more pros than cons.

    PubMed

    Jensen-Jarolim, Erika; Singer, Josef

    2011-09-01

    To date, passive immunotherapy with monoclonal antibodies is a well-established option in clinical oncology. By contrast, anticancer vaccines are less advanced, with the exception of successfully applied prophylactic vaccines against oncogenic virus infections. The creation of therapeutic vaccines is still a great challenge mostly due to the self-nature of tumor antigens. Therapeutic vaccines may be based on patient-specific material including pulsed effector cells, or tumor-associated antigens and derivatives thereof, such as peptides, mimotopes and nucleic acids. The latter represents a more universal approach, which would set an ideal economic framework resulting in broad patient access. In this article we focus on cancer vaccines for antibody production, in particular mimotope vaccines. The collected evidence suggests that they will open up new treatment options in minimal residual disease and early stage disease.

  14. The historical roots of the "bipolar spectrum": did Aristotle anticipate Kraepelin's broad concept of manic-depression?

    PubMed

    Pies, Ronald

    2007-06-01

    The construct of bipolar disorder, or bipolar spectrum disorders, has been a source of controversy in recent years. Some have argued that subtle variants within the putative bipolar spectrum are merely the creation of overzealous clinicians, perhaps encouraged by various special interest groups. In reality, the concept of a bipolar spectrum may be inferred from numerous classical sources, dating back to the 19th century and even into antiquity. The Greek philosopher Aristotle, usually considered the author of a work called Problemata, appears to have recognized some form of the bipolar spectrum, more than two millennia ago. This recognition continues throughout the 19th century, and into our own time. Such transcultural findings across many centuries have implications for the "objective" nature of psychiatric disease.

  15. Reducing the unexpectedly high rate of injuries caused by NOTES gastrotomy creation.

    PubMed

    Sohn, Dae Kyung; Turner, Brian G; Gee, Denise W; Willingham, Field F; Sylla, Patricia; Cizginer, Sevdenur; Konuk, Yusuf; Brugge, William R; Rattner, David W

    2010-02-01

    Despite the wide range of natural orifice transluminal endoscopic surgery (NOTES) procedures reported to date using a transgastric endoscopic approach, complications associated with gastrotomy creation have not been described. This study was conducted to identify the incidence and types of complications related to gastrotomy creation with the needle knife puncture and balloon dilatation technique for NOTES access to the peritoneal cavity. Between May 2007 and August 2008, transgastric procedures were performed in 76 swine at a single institution. A total of 58 gastrotomies were created using the needle knife puncture and balloon dilatation technique without laparoscopic observation and 18 gastrotomies were created under laparoscopic visualization after CO(2) insufflation through a laparoscopic port. In all cases, a needle knife with an electrosurgical current of 25-W coagulation and/or 25-W cut and a wire-guided endoscopic balloon dilated to 20 mm were used to create the gastrotomy. All complications were collected prospectively and reviewed from laboratory medical records, operative reports, and necropsy findings. NOTES gastrotomy-related complications occurred in 10/76 (13.2%) animals. Major complications occurred in six animals (7.9%), including four splenic lacerations, a mesenteric tear, and a fatal diaphragmatic injury. Minor complications occurred in four animals (5.3%), including three abdominal wall injuries and minor gastrotomy site bleeding. When pregastrotomy laparoscopic guidance was used, only one injury occurred in 18 animals (5.5%), but 9/58 (15.5%) gastrotomies performed without laparoscopic visualization caused some type of injury. The difference in rate of injury did not achieve statistical significance. No learning curve effect could be identified. Injuries to adjacent viscera occur more often than is reported with the traditional transgastric needle knife NOTES access technique. Gastric punctures should be made either with laparoscopic visualization or by other techniques such as the PEG approach or with noncutting devices to reduce the incidence of visceral injury associated with transgastric peritoneal entry.

  16. Solar test of Dirac's large number hypothesis. [multiplicative creation model for solar evolution

    NASA Technical Reports Server (NTRS)

    Chin, C.-W.; Stothers, R.

    1975-01-01

    An investigation is conducted regarding the implications of Dirac's theories (1973, 1974) concerning the creation of new matter. It is found that Dirac's theory of multiplicative creation, but not his theory of additive creation, is not in contradiction with known facts about the sun. According to the theory of additive creation, matter is formed uniformly throughout space. The concept of multiplicative creation implies that existing matter multiplies itself in proportion to the amount of matter already present.

  17. Modified-Fibonacci-Dual-Lucas method for earthquake prediction

    NASA Astrophysics Data System (ADS)

    Boucouvalas, A. C.; Gkasios, M.; Tselikas, N. T.; Drakatos, G.

    2015-06-01

    The FDL method makes use of Fibonacci, Dual and Lucas numbers and has shown considerable success in predicting earthquake events locally as well as globally. Predicting the location of the epicenter of an earthquake is one difficult challenge the other being the timing and magnitude. One technique for predicting the onset of earthquakes is the use of cycles, and the discovery of periodicity. Part of this category is the reported FDL method. The basis of the reported FDL method is the creation of FDL future dates based on the onset date of significant earthquakes. The assumption being that each occurred earthquake discontinuity can be thought of as a generating source of FDL time series The connection between past earthquakes and future earthquakes based on FDL numbers has also been reported with sample earthquakes since 1900. Using clustering methods it has been shown that significant earthquakes (<6.5R) can be predicted with very good accuracy window (+-1 day). In this contribution we present an improvement modification to the FDL method, the MFDL method, which performs better than the FDL. We use the FDL numbers to develop possible earthquakes dates but with the important difference that the starting seed date is a trigger planetary aspect prior to the earthquake. Typical planetary aspects are Moon conjunct Sun, Moon opposite Sun, Moon conjunct or opposite North or South Modes. In order to test improvement of the method we used all +8R earthquakes recorded since 1900, (86 earthquakes from USGS data). We have developed the FDL numbers for each of those seeds, and examined the earthquake hit rates (for a window of 3, i.e. +-1 day of target date) and for <6.5R. The successes are counted for each one of the 86 earthquake seeds and we compare the MFDL method with the FDL method. In every case we find improvement when the starting seed date is on the planetary trigger date prior to the earthquake. We observe no improvement only when a planetary trigger coincided with the earthquake date and in this case the FDL method coincides with the MFDL. Based on the MDFL method we present the prediction method capable of predicting global events or localized earthquakes and we will discuss the accuracy of the method in as far as the prediction and location parts of the method. We show example calendar style predictions for global events as well as for the Greek region using planetary alignment seeds.

  18. How Co-Creation Helped Address Hierarchy, Overwhelmed Patients, and Conflicts of Interest in Health Care Quality and Safety.

    PubMed

    Israilov, Sigal; Cho, Hyung J

    2017-11-01

    Co-creation is health professionals' and systems' development of health care together with patients and families. Such collaborations yield an exchange of values, ideas, and priorities that can individualize care for each patient. Co-creation has been discussed interchangeably with co-production and shared decision making; this article explores co-creation through the lens of quality improvement. Although there are barriers to co-creation including physician autonomy, patient overwhelm, and conflicts of interest, co-creation has been shown to promote patient engagement, peer learning, and improved outcomes. Further research is needed in co-creation for systems improvement. © 2017 American Medical Association. All Rights Reserved.

  19. Defensive Cyber Battle Damage Assessment Through Attack Methodology Modeling

    DTIC Science & Technology

    2011-03-25

    ASL Creation ............................................................... 68 3.3.4. Evidence Evaluation and EML Creation...90 4.2.3. COA Analysis and ASL Creation ............................................................... 92 4.2.4. Evidence Evaluation and EML ...Evidence Evaluation and EML Creation. .................................................... 70 18. DCBDA Forensic Analysis

  20. Value co-creation in healthcare through positive deviance.

    PubMed

    Zanetti, Cole Anthony; Taylor, Natalie

    2016-12-01

    To explore how converging fields of co-creation and positive deviance may increase value in healthcare. Informed by research in positive deviance, patient engagement, value co-creation, and quality improvement, we propose a positive deviance approach to co-creation of health. Co-creation has shown to improve health outcomes with regard to multiple health conditions. Positive deviance has also shown to improve outcomes in multiple healthcare and patient community environments. A positive deviance co-creation framework may aid in achieving improved outcomes for patients, care teams and their respective healthcare organizations. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Effect of traditional plants in Sri Lanka on skin fibroblast cell number.

    PubMed

    Sano, Katsura; Someya, Takao; Hara, Kotaro; Sagane, Yoshimasa; Watanabe, Toshihiro; Wijesekara, R G S

    2018-08-01

    This article describes the effects of extracts of several plants collected in Sri Lanka on the cell number of human skin fibroblasts. This study especially focuses on the plants traditionally used in indigenous systems of medicine in Sri Lanka, such as Ayurveda, as described below (English name, "local name in Sri Lanka," scientific name). Bougainvillea plant, "bouganvilla," Bougainvillea grabla (Nature׳s Beauty Creations Ltd., 2014) [1], purple fruited pea eggplant,"welthibbatu," Solanum trilobatum (Nature׳s Beauty Creations Ltd., 2014) [2], country borage plant, "kapparawalliya," Plectranthus amboinicus  (Nature׳s Beauty Creations Ltd., 2014) [3], malabar nut plant, "adhatoda," Justicia adhatoda (Nature׳s Beauty Creations Ltd., 2014) [4], long pepper plant,"thippili," Piper longum (Nature׳s Beauty Creations Ltd., 2014) [5], holy basil plant, "maduruthala," Ocimum tenuiflorum (Nature׳s Beauty Creations Ltd., 2014) [6], air plant, "akkapana," Kalanchoe pinnata (Nature׳s Beauty Creations Ltd., 2014) [7], plumed cockscomb plant, "kiri-henda," Celosia argentea (Nature׳s Beauty Creations Ltd., 2014) [8], neem plant,"kohomba," Azadirachta indica (Nature׳s Beauty Creations Ltd., 2014) [9], emblic myrobalan plant, "nelli," Phyllanthus emblica (Nature׳s Beauty Creations Ltd., 2014) [10]. Human skin fibroblast cells were treated with various concentration of plant extracts (0-3.0%), and the cell viability of cells were detected using calcein assay. The cell viabillity profiles are provided as line graphs.

  2. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2003-11-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  3. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    Euzéby, Jean

    2010-05-01

    The purpose of this announcement is to effect the valid publication of the following effectively published new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries. It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  4. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2006-01-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  5. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2006-05-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  6. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    Euzéby, Jean

    2006-09-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  7. Scientific Creationism: A Case Study.

    ERIC Educational Resources Information Center

    Pipho, Chris

    1981-01-01

    Describes the current movement to elevate biblical creationism to a scientific theory to be taught alongside evolution in the public schools. Focuses on the strategies and influence of pro "scientific creationism" groups and reviews pending legislation that would mandate equal teaching time for creationism. (GC)

  8. Co-creating value through demand and supply integration in senior industry-observations on 33 senior enterprises in Taiwan.

    PubMed

    Yang, Ya-Ting; Iqbal, Usman; Chen, Ya-Mei; Su, Shyi; Chang, Yao-Mao; Handa, Yujiro; Lin, Neng-Pai; Hsu, Yi-Hsin Elsa

    2016-09-01

    With global population aging, great business opportunities are driven by the various needs that the elderly face in everyday living. Internet development makes information spread faster, also allows elderly and their caregivers to more easily access information and actively participate in value co-creation in the services. This study aims to investigate the designs of value co-creation by the supply and demand sides of the senior industry. This study investigated senior industry in Taiwan and analyzed bussiness models of 33 selected successful senior enterprises in 2013. We adopted series field observation, reviews of documentations, analysis of meeting records and in-depth interviews with 65 CEOs and managers. Thirty-three quality enterprises in senior industry. Sixty-five CEOs and managers in 33 senior enterprises. None. Value co-creation design, value co-creating process. We constructed a conceptual model that comprehensively describes essential aspects of value co-creation and categorized the value co-creation designs into four types applying for different business models: (i) interaction in experience spaces co-creation design, (ii) on-site interacting co-creation design, (iii) social networking platform co-creation design and (iv) empowering customers co-creation design. Through value co-creation platform design, the senior enterprises have converted the originally passive roles of the elderly and caregivers into active participants in the value co-creation process. The new paradigm of value co-creation designs not only promote innovative development during the interactive process, lead enterprises reveal and meet customers' needs but also increase markets and profits. © The Author 2016. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  9. An Automated Telescope for Education and Outreach

    NASA Astrophysics Data System (ADS)

    Burks, G. S.; Guzik, T. G.; Tohline, J. E.; Landolt, A.

    1997-12-01

    In this time of limited resources, the problem of providing an up to date facility for education and outreach needs to be addressed. One solution to this problem is a joint venture between Louisiana State University, BREC (the Park and creation Commission of East Baton Rouge Parish), and BRAS (the Baton Rouge Astronomical Society). The result of this collaboration is a facility with outreach and educational space, a 20 inch Ritchey-Chretien telescope with CCD camera, and volunteers from the amateur community for help with the outreach mission. We present an overview of the project, and show how the telescope will be completely automated to allow use of the telescope by LSU students and our outreach partners on the Internet. We explore the possibility for use of this facility by a world wide audience over the web.

  10. Deterministic Squeezed States with Collective Measurements and Feedback.

    PubMed

    Cox, Kevin C; Greve, Graham P; Weiner, Joshua M; Thompson, James K

    2016-03-04

    We demonstrate the creation of entangled, spin-squeezed states using a collective, or joint, measurement and real-time feedback. The pseudospin state of an ensemble of N=5×10^{4} laser-cooled ^{87}Rb atoms is deterministically driven to a specified population state with angular resolution that is a factor of 5.5(8) [7.4(6) dB] in variance below the standard quantum limit for unentangled atoms-comparable to the best enhancements using only unitary evolution. Without feedback, conditioning on the outcome of the joint premeasurement, we directly observe up to 59(8) times [17.7(6) dB] improvement in quantum phase variance relative to the standard quantum limit for N=4×10^{5}  atoms. This is one of the largest reported entanglement enhancements to date in any system.

  11. Extraordinary Matter: Visualizing Space Plasmas and Particles

    NASA Astrophysics Data System (ADS)

    Barbier, S. B.; Bartolone, L.; Christian, E. R.; Eastman, T.; Lewis, E.; Thieman, J.

    2010-08-01

    We present an online NASA multimedia library, now in development, designed to assist educators with explaining concepts of basic particle and plasma physics. Such resources are few in number and/or difficult to locate, and most do not provide suitable context. On our Extraordinary Matter site, each product will be accompanied by an explanation at a reading level matching the concept's educational level, link to the source, educational standards addressed, file size, use restrictions, credits, format(s), creation date and, optionally, associated educational activities and other relevant information and links. The site will target grades 9-14 and the equivalent in informal education and outreach. Products are intended to stand alone, making them adaptable to the widest range of uses. This project is funded by the NASA EPOESS Program in response to NRA NNH08ZDA001N for ROSES-2008.

  12. Creation of the Hubble Space Telescope

    NASA Astrophysics Data System (ADS)

    O'Dell, C. R.

    2009-08-01

    The Hubble Space Telescope has been the most successful space astronomy project to date, producing images that put the public in awe and images and spectra that have produced many scientific discoveries. It is the natural culmination of a dream envisioned when rocket flight into space was first projected and a goal set for the US space program soon after NASA was created. The design and construction period lasted almost two decades and its operations have already lasted almost as long. The capabilities of the observatory have evolved and expanded with periodic upgrading of its instrumentation, thus realizing the advantages of its unique design. The success of this long-lived observatory is closely tied to the availability of the Space Shuttle and the end of the Shuttle program means that the end of the Hubble program will follow before long.

  13. The astronomy of Andean myth: The history of a cosmology

    NASA Astrophysics Data System (ADS)

    Sullivan, William F.

    It is shown that Andean myth, on one level, represents a technical language recording astronomical observations of precession and, at the same time, an historical record of simultaneous social and celestial transformations. Topographic and architectural terms of Andean myth are interpreted as a metaphor for the organization of and locations on the celestial sphere. Via ethoastronomical date, mythical animals are identified as stars and placed on the celestial sphere according to their topographical location. Tested in the planetarium, these arrays generate cluster of dates - 200 B.C. and 650 A.D. Analysis of the names of Wiraqocha and Manco Capac indicates they represent Saturn and Jupiter and that their mythical meeting represents their conjunction in 650 A.D. The astronomy of Andean myth is then used as an historical tool to examine how the Andean priest-astronomers recorded the simultaneous creation of the avllu and of this distinctive astronomical system about 200 B.C. The idea that the agricultural avllu, with its double descent system stressing the importance of paternity, represents a transformation of society from an earlier matrilineal/horticultural era is examined in light of the sexual imagery employed in myth. Wiraqocha's androgyny and the division of the celestial sphere into male (ecliptic) and female (celestial equator = earth) are interpreted as cosmological validations of the new social structure.

  14. Using a Co-Creational Approach to Develop, Implement and Evaluate an Intervention to Promote Physical Activity in Adolescent Girls from Vocational and Technical Schools: A Case Control Study

    PubMed Central

    Verloigne, Maïté; Altenburg, Teatske Maria; Chinapaw, Mai Jeanette Maidy; Chastin, Sebastien; Cardon, Greet

    2017-01-01

    Background: As physical inactivity is particularly prevalent amongst lower-educated adolescent girls, interventions are needed. Using a co-creational approach increases their engagement and might be effective. This study aimed to: (1) describe the co-creation process, (2) evaluate how girls experienced co-creation, and (3) evaluate the effect of the co-creational interventions on physical activity, individual, sociocultural and school-based factors. Methods: Three intervention schools (n = 91) and three control schools (n = 105) across Flanders participated. A questionnaire was completed pre (September–October 2014) and post (April–May 2015). In between, sessions with a co-creation group were organised to develop and implement the intervention in each intervention school. Focus groups were conducted to evaluate the co-creational process. Results: School 1 organised sport sessions for girls, school 2 organised a fitness activity and set up a Facebook page, school 3 organised a lunch walk. Girls were positive about having a voice in developing an intervention. No significant effects were found, except for small effects on extracurricular sports participation and self-efficacy. Conclusions: Using a co-creational approach amongst adolescent girls might be a feasible approach. However, as interventions were minimal, effects were limited or undetectable. Future co-creation projects could consider the most optimal co-creation process, evaluation design and intensively test this approach. PMID:28763041

  15. Using a Co-Creational Approach to Develop, Implement and Evaluate an Intervention to Promote Physical Activity in Adolescent Girls from Vocational and Technical Schools: A Case Control Study.

    PubMed

    Verloigne, Maïté; Altenburg, Teatske Maria; Chinapaw, Mai Jeanette Maidy; Chastin, Sebastien; Cardon, Greet; De Bourdeaudhuij, Ilse

    2017-08-01

    Background: As physical inactivity is particularly prevalent amongst lower-educated adolescent girls, interventions are needed. Using a co-creational approach increases their engagement and might be effective. This study aimed to: (1) describe the co-creation process, (2) evaluate how girls experienced co-creation, and (3) evaluate the effect of the co-creational interventions on physical activity, individual, sociocultural and school-based factors. Methods: Three intervention schools (n = 91) and three control schools (n = 105) across Flanders participated. A questionnaire was completed pre (September-October 2014) and post (April-May 2015). In between, sessions with a co-creation group were organised to develop and implement the intervention in each intervention school. Focus groups were conducted to evaluate the co-creational process. Results: School 1 organised sport sessions for girls, school 2 organised a fitness activity and set up a Facebook page, school 3 organised a lunch walk. Girls were positive about having a voice in developing an intervention. No significant effects were found, except for small effects on extracurricular sports participation and self-efficacy. Conclusions: Using a co-creational approach amongst adolescent girls might be a feasible approach. However, as interventions were minimal, effects were limited or undetectable. Future co-creation projects could consider the most optimal co-creation process, evaluation design and intensively test this approach.

  16. Phase transition in conservative diffusive contact processes

    NASA Astrophysics Data System (ADS)

    Fiore, Carlos E.; de Oliveira, Mário J.

    2004-10-01

    We determine the phase diagrams of conservative diffusive contact processes by means of numerical simulations. These models are versions of the ordinary diffusive single-creation, pair-creation, and triplet-creation contact processes in which the particle number is conserved. The transition between the frozen and active states was determined by studying the system in the subcritical regime, and the nature of the transition, whether continuous or first order, was determined by looking at the fractal dimension of the critical cluster. For the single-creation model the transition remains continuous for any diffusion rate. For pair- and triplet-creation models, however, the transition becomes first order for high enough diffusion rate. Our results indicate that in the limit of infinite diffusion rate the jump in density equals 2/3 for the pair-creation model and 5/6 for the triplet-creation model.

  17. National Institute for Rocket Propulsion Systems 2012 Annual Report: A Year of Progress and Challenge

    NASA Technical Reports Server (NTRS)

    Thomas, L. Dale; Doreswamy, Rajiv; Fry, Emma Kiele

    2013-01-01

    The National Institute for Rocket Propulsion Systems (NIRPS) maintains and advances U.S. leadership in all aspects of rocket propulsion for defense, civil, and commercial uses. The Institute's creation is in response to widely acknowledged concerns about the U.S. rocket propulsion base dating back more than a decade. U.S. leadership in rocket and missile propulsion is threatened by long-term industry downsizing, a shortage of new solid and liquid propulsion programs, limited ability to attract and retain fresh talent, and discretionary federal budget pressures. Numerous trade and independent studies cite erosion of this capability as a threat to national security and the U.S. economy resulting in a loss of global competitiveness for the U.S. propulsion industry. This report covers the period between May 2011 and December 2012, which includes the creation and transition to operations of NIRPS. All subsequent reports will be annual. The year 2012 has been an eventful one for NIRPS. In its first full year, the new team overcame many obstacles and explored opportunities to ensure the institute has a firm foundation for the future. NIRPS is now an active organization making contributions to the development, sustainment, and strategy of the rocket propulsion industry in the United States. This report describes the actions taken by the NIRPS team to determine the strategy, organizational structure, and goals of the Institute. It also highlights key accomplishments, collaborations with other organizations, and the strategic framework for the Institute.

  18. FROM THE HISTORY OF PHYSICS: On the making of the Soviet hydrogen (thermonuclear) bomb

    NASA Astrophysics Data System (ADS)

    Khariton, Yu B.; Adamskii, V. B.; Smirnov, Yu N.

    1996-02-01

    The May 1991 issue of Uspekhi Fizicheskikh Nauk (Physics-Uspekhi), devoted to the 70th birthday of Andrei Dmitrievich Sakharov, included a translation of an article by D Hirsch and W Mathews, 'The H-bomb: Who Really Gave Away the Secret?' It was the Editors' hope that, prompted by this polemic and in many respects controversial publication, our physicists and nuclear weapons developers would speak out too. However, it is only now, five years later and with a number of formal restrictions lifted, that the Journal has received an article on the creation of the Soviet H-bomb written by Arzamas-16 (All-Union Research Institute of Experimental Physics) specialists (of whom Yu N Smirnov worked under A D Sakharov in the 1960s). The Editors are confident that this article will be of interest to our readers. What makes the article particularly authoritative is the co-authorship of Yulii Borisovich Khariton, a patriarch of national nuclear physicists. His brilliant debut dating back to the 1920s was made in the N N Semyonov group and at the famous Cavendsh Laboratory (then under E Rutherford); from 1946 to 1992 Yu B Khariton was a permanent scientific leader of the Arzamas-16 Nuclear Weapons Centre. It is primarily to I V Kurchatov and Yu B Khariton that we owe the creation of our nuclear weapons which laid the groundwork for the country's powerful defence potential. Editorial Board.

  19. Probability Distributions over Cryptographic Protocols

    DTIC Science & Technology

    2009-06-01

    Artificial Immune Algorithm . . . . . . . . . . . . . . . . . . . 9 3 Design Decisions 11 3.1 Common Ground...creation algorithm for unbounded distribution . . . . . . . 24 4.2 Message creation algorithm for unbounded naive distribution . . . . 24 4.3 Protocol...creation algorithm for intended-run distributions . . . . . . 26 4.4 Protocol and message creation algorithm for realistic distribution . . 32 ix THIS

  20. Performance Scripts Creation: Processes and Applications

    ERIC Educational Resources Information Center

    Lyons, Paul

    2006-01-01

    Purpose: Seeks to explain some of the dynamics of scripts creation as used in training, to offer some theoretical underpinning regarding the influence of script creation on behavior and performance, and to offer some examples of how script creation is applied in training activities. Design/methodology/approach: The paper explains in detail and…

  1. 15 CFR 2001.1 - Creation and location.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Creation and location. 2001.1 Section 2001.1 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE CREATION, ORGANIZATION, AND FUNCTIONS § 2001.1 Creation and location. (a) The...

  2. 15 CFR 2001.1 - Creation and location.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Creation and location. 2001.1 Section 2001.1 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE CREATION, ORGANIZATION, AND FUNCTIONS § 2001.1 Creation and location. (a) The...

  3. 17 CFR 45.3 - Swap data reporting: creation data.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Swap data reporting: creation... (CONTINUED) SWAP DATA RECORDKEEPING AND REPORTING REQUIREMENTS § 45.3 Swap data reporting: creation data. Registered entities and swap counterparties must report required swap creation data electronically to a swap...

  4. 15 CFR 2001.1 - Creation and location.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Creation and location. 2001.1 Section 2001.1 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE CREATION, ORGANIZATION, AND FUNCTIONS § 2001.1 Creation and location. (a) The...

  5. 15 CFR 2001.1 - Creation and location.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Creation and location. 2001.1 Section 2001.1 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE CREATION, ORGANIZATION, AND FUNCTIONS § 2001.1 Creation and location. (a) The...

  6. 15 CFR 2001.1 - Creation and location.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Creation and location. 2001.1 Section 2001.1 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE CREATION, ORGANIZATION, AND FUNCTIONS § 2001.1 Creation and location. (a) The...

  7. Molecular-genetic diagnostics of von Hippel-Lindau syndrome (VHL) in Bulgaria: first complex mutation event in the VHL gene.

    PubMed

    Glushkova, Maria; Dimova, Petia; Yordanova, Iglika; Todorov, Tihomir; Tourtourikov, Ivan; Mitev, Vanyo; Todorova, Albena

    2018-02-01

    Von Hippel-Lindau syndrome is an autosomal-dominant disease characterized by the formation of various tumours and cysts in many different parts of the body. Von Hippel-Lindau syndrome is caused by VHL gene mutations leading to production of impaired tumor suppressor Von Hippel-Lindau syndrome protein or its complete absence. To study five patients with clinically suspected Von Hippel-Lindau syndrome, who were referred for molecular genetic testing. Sanger sequencing of the coding regions of the VHL gene. Five clinically relevant germline mutations were detected. One of the pathogenic variants has not been previously reported. This novel mutation is a complex mutation event combining a duplication and an indel, rearranging exon 3 of the VHL gene - c. [516_517dupGTCAAGCCT; 532_542delCTGGACATCGTinsATTA], p. (Glu173Serfs*4). Overall, our results showed that the diagnosis of Von Hippel-Lindau syndrome in our country is difficult most probably because of its heterogeneous clinical manifestation and insufficient knowledge on the diagnostic criteria for the disease. From genetic point of view our results add some novel data on the mutation profile of the VHL gene. In order to prove or revise the diagnosis, early genetic testing is strongly recommended in affected patients and their family members to ensure appropriate follow-up and treatment of the malignancies.

  8. Mutations in the calcium-related gene IL1RAPL1 are associated with autism.

    PubMed

    Piton, Amélie; Michaud, Jacques L; Peng, Huashan; Aradhya, Swaroop; Gauthier, Julie; Mottron, Laurent; Champagne, Nathalie; Lafrenière, Ronald G; Hamdan, Fadi F; Joober, Ridha; Fombonne, Eric; Marineau, Claude; Cossette, Patrick; Dubé, Marie-Pierre; Haghighi, Pejmun; Drapeau, Pierre; Barker, Philip A; Carbonetto, Salvatore; Rouleau, Guy A

    2008-12-15

    In a systematic sequencing screen of synaptic genes on the X chromosome, we have identified an autistic female without mental retardation (MR) who carries a de novo frameshift Ile367SerfsX6 mutation in Interleukin-1 Receptor Accessory Protein-Like 1 (IL1RAPL1), a gene implicated in calcium-regulated vesicle release and dendrite differentiation. We showed that the function of the resulting truncated IL1RAPL1 protein is severely altered in hippocampal neurons, by measuring its effect on neurite outgrowth activity. We also sequenced the coding region of the close related member IL1RAPL2 and of NCS-1/FREQ, which physically interacts with IL1RAPL1, in a cohort of subjects with autism. The screening failed to identify non-synonymous variant in IL1RAPL2, whereas a rare missense (R102Q) in NCS-1/FREQ was identified in one autistic patient. Furthermore, we identified by comparative genomic hybridization a large intragenic deletion of exons 3-7 of IL1RAPL1 in three brothers with autism and/or MR. This deletion causes a frameshift and the introduction of a premature stop codon, Ala28GlufsX15, at the very beginning of the protein. All together, our results indicate that mutations in IL1RAPL1 cause a spectrum of neurological impairments ranging from MR to high functioning autism.

  9. Modern dual-mobility cup implanted with an uncemented stem: about 100 cases with 12-year follow-up.

    PubMed

    Philippot, Remi; Meucci, Jean Francois; Boyer, Bertrand; Farizon, Frederic

    2013-09-01

    We report the results of a 12-year follow-up retrospective series of 100 total hip arthroplasties using cementless, press-fit, dual-mobility acetabular cups. The aim of our study was to evaluate the clinical and radiographic results of this acetabular cup at last follow-up. This continuous and homogeneous series included 100 primary total hip arthroplasties performed during the year 2000. The THA combined a Corail® stem (Corail®, Depuy, Warsaw, IN) with a stainless steel Novae Sunfit® (Serf, Decines, France) acetabular cup. Fifteen patients died and 2 were lost to follow-up. Two cases of early dislocation were observed, and 3 cases of aseptic loosening of the acetabular component were reported. The mean stem subsidence was 0.71 mm, the mean craniopodal acetabular migration was 1.37 mm, and the mean medio-lateral acetabular migration was 1.52 mm. The 12-year survivorship is comparable to the data from the literature. The low dislocation rate at 12 years confirms the long-term, high stability of dual mobility, which should be recommended in primary THA for patients at risk for postoperative instability. The absence of true intraprosthetic dislocation events at 12-year follow-up provides evidence of the good quality of the latest generation of polyethylene liners and the necessity of combining thin-mirror, polished femoral necks with dual-mobility cups.

  10. Super-nonlinear fluorescence microscopy for high-contrast deep tissue imaging

    NASA Astrophysics Data System (ADS)

    Wei, Lu; Zhu, Xinxin; Chen, Zhixing; Min, Wei

    2014-02-01

    Two-photon excited fluorescence microscopy (TPFM) offers the highest penetration depth with subcellular resolution in light microscopy, due to its unique advantage of nonlinear excitation. However, a fundamental imaging-depth limit, accompanied by a vanishing signal-to-background contrast, still exists for TPFM when imaging deep into scattering samples. Formally, the focusing depth, at which the in-focus signal and the out-of-focus background are equal to each other, is defined as the fundamental imaging-depth limit. To go beyond this imaging-depth limit of TPFM, we report a new class of super-nonlinear fluorescence microscopy for high-contrast deep tissue imaging, including multiphoton activation and imaging (MPAI) harnessing novel photo-activatable fluorophores, stimulated emission reduced fluorescence (SERF) microscopy by adding a weak laser beam for stimulated emission, and two-photon induced focal saturation imaging with preferential depletion of ground-state fluorophores at focus. The resulting image contrasts all exhibit a higher-order (third- or fourth- order) nonlinear signal dependence on laser intensity than that in the standard TPFM. Both the physical principles and the imaging demonstrations will be provided for each super-nonlinear microscopy. In all these techniques, the created super-nonlinearity significantly enhances the imaging contrast and concurrently extends the imaging depth-limit of TPFM. Conceptually different from conventional multiphoton processes mediated by virtual states, our strategy constitutes a new class of fluorescence microscopy where high-order nonlinearity is mediated by real population transfer.

  11. "Origin," "creation," and "origin of life" some conceptual considerations.

    PubMed

    Charpa, Ulrich

    2012-01-01

    This paper opens by drawing attention to the fact that there is some conceptual confusion with regard to "origin" and "creation." This has its historical roots in the beginnings of modern science and undoubtedly affects our positioning towards the evolutionism/creationism-debate. This article argues that there are relevant ontological, epistemological, thematic, methodological, and logical differences between "origin" and "creation." As a result, the analysis suggests keeping the usage of both concepts strictly quite separate. Creation is not simply another word for origin nor does it stand for an (from a rigid scientific point of view) awkward example of an origin. Irrespective of the apparent similarities as explanatory factors, origin and creation belong to fundamentally different types of concepts. Consequently, "origin of life" and those scientific projects connected to it present themselves as something distinct that neither competes nor meshes with thinking about creation.

  12. Creation of vector bosons by an electric field in curved spacetime

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kangal, E. Ersin; Yanar, Hilmi; Havare, Ali

    2014-04-15

    We investigate the creation rate of massive spin-1 bosons in the de Sitter universe by a time-dependent electric field via the Duffin–Kemmer–Petiau (DKP) equation. Complete solutions are given by the Whittaker functions and particle creation rate is computed by using the Bogoliubov transformation technique. We analyze the influence of the electric field on the particle creation rate for the strong and vanishing electric fields. We show that the electric field amplifies the creation rate of charged, massive spin-1 particles. This effect is analyzed by considering similar calculations performed for scalar and spin-1/2 particles. -- Highlights: •Duffin–Kemmer–Petiau equation is solved exactlymore » in the presence of an electrical field. •Solutions were made in (1+1)-dimensional curved spacetime. •Particle creation rate for the de Sitter model is calculated. •Pure gravitational or pure electrical field effect on the creation rate is analyzed.« less

  13. Creationism in the Biology Classroom: What Do Teachers Teach & How Do They Teach It?

    ERIC Educational Resources Information Center

    Moore, Randy

    2008-01-01

    Approximately one-fourth of biology teachers in public schools include creationism in their biology courses. Most of these teachers 1) present creationism as a scientific alternative to evolution, and 2) present only the biblical (i.e., Christian) story of creation. State science-education standards, position statements from professional…

  14. Knowledge Creation and Innovation in a Civil Engineering Course for the First-Year University Students

    ERIC Educational Resources Information Center

    Salmisto, Alpo; Nokelainen, Petri

    2015-01-01

    This article examines the application of knowledge creation learning and innovation to higher education in construction. The objectives are to demonstrate the application of the course based on knowledge creation learning to mass teaching and to analyse whether knowledge creation learning improves student motivation and learning. The empirical…

  15. A combined qualitative-quantitative approach for the identification of highly co-creative technology-driven firms

    NASA Astrophysics Data System (ADS)

    Milyakov, Hristo; Tanev, Stoyan; Ruskov, Petko

    2011-03-01

    Value co-creation, is an emerging business and innovation paradigm, however, there is not enough clarity on the distinctive characteristics of value co-creation as compared to more traditional value creation approaches. The present paper summarizes the results from an empirically-derived research study focusing on the development of a systematic procedure for the identification of firms that are active in value co-creation. The study is based on a sample 273 firms that were selected for being representative of the breadth of their value co-creation activities. The results include: i) the identification of the key components of value co-creation based on a research methodology using web search and Principal Component Analysis techniques, and ii) the comparison of two different classification techniques identifying the firms with the highest degree of involvement in value co-creation practices. To the best of our knowledge this is the first study using sophisticated data collection techniques to provide a classification of firms according to the degree of their involvement in value co-creation.

  16. Fistula and Survival Outcomes after Fistula Creation among Predialysis Chronic Kidney Disease Stage 5 Patients.

    PubMed

    Miyamoto, Masahito; Kurita, Noriaki; Suemitsu, Kotaro; Murakami, Masaaki

    2017-01-01

    Most guidelines recommend the creation of arteriovenous fistula (AVF) in patients with chronic kidney disease (CKD) stage 4. However, an increasing number of studies suggest that early AVF creation leads to high rates of AVF failure and death before dialysis commencement. Only the Japanese guideline recommends AVF creation at CKD stage 5; however, no data are available regarding access-related outcomes at this stage. This was a multicenter cohort study involving Japanese CKD stage 5 patients who underwent preemptive AVF creation from 2009 to 2013. The primary outcome was unnecessary AVF creation, defined as death before requiring dialysis or AVF failure before dialysis commencement. The secondary outcome was dialysis commencement. The associations with candidate predictors and the outcomes were examined. A total of 303 patients were registered. Four cases of death before dialysis and 13 cases of AVF failure before dialysis commencement were observed. A total of 283 patients who advanced to dialysis were found to have functional AVFs. The cumulative incidences of unnecessary AVF creation and dialysis commencement at 1 year were 4.8 and 89.3%, respectively. Competing risk regression analyses showed that age ≥75 years (subhazard ratio [SHR] 3.12, 95% CI 1.20-8.09) and female gender (SHR 3.31, 95% CI 1.20-9.09) were associated with unnecessary AVF creation. A low incidence of unnecessary AVF creation was revealed among Japanese patients who received AVF at CKD stage 5. These results may help clarify the natural history of unnecessary AVF creation for other countries reformatting their guidelines regarding late vascular access creation. © 2017 S. Karger AG, Basel.

  17. Voluntary medical male circumcision: a qualitative study exploring the challenges of costing demand creation in eastern and southern Africa.

    PubMed

    Bertrand, Jane T; Njeuhmeli, Emmanuel; Forsythe, Steven; Mattison, Sarah K; Mahler, Hally; Hankins, Catherine A

    2011-01-01

    This paper proposes an approach to estimating the costs of demand creation for voluntary medical male circumcision (VMMC) scale-up in 13 countries of eastern and southern Africa. It addresses two key questions: (1) what are the elements of a standardized package for demand creation? And (2) what challenges exist and must be taken into account in estimating the costs of demand creation? We conducted a key informant study on VMMC demand creation using purposive sampling to recruit seven people who provide technical assistance to government programs and manage budgets for VMMC demand creation. Key informants provided their views on the important elements of VMMC demand creation and the most effective funding allocations across different types of communication approaches (e.g., mass media, small media, outreach/mobilization). The key finding was the wide range of views, suggesting that a standard package of core demand creation elements would not be universally applicable. This underscored the importance of tailoring demand creation strategies and estimates to specific country contexts before estimating costs. The key informant interviews, supplemented by the researchers' field experience, identified these issues to be addressed in future costing exercises: variations in the cost of VMMC demand creation activities by country and program, decisions about the quality and comprehensiveness of programming, and lack of data on critical elements needed to "trigger the decision" among eligible men. Based on this study's findings, we propose a seven-step methodological approach to estimate the cost of VMMC scale-up in a priority country, based on our key assumptions. However, further work is needed to better understand core components of a demand creation package and how to cost them. Notwithstanding the methodological challenges, estimating the cost of demand creation remains an essential element in deriving estimates of the total costs for VMMC scale-up in eastern and southern Africa.

  18. Voluntary Medical Male Circumcision: A Qualitative Study Exploring the Challenges of Costing Demand Creation in Eastern and Southern Africa

    PubMed Central

    Bertrand, Jane T.; Njeuhmeli, Emmanuel; Forsythe, Steven; Mattison, Sarah K.; Mahler, Hally; Hankins, Catherine A.

    2011-01-01

    Background This paper proposes an approach to estimating the costs of demand creation for voluntary medical male circumcision (VMMC) scale-up in 13 countries of eastern and southern Africa. It addresses two key questions: (1) what are the elements of a standardized package for demand creation? And (2) what challenges exist and must be taken into account in estimating the costs of demand creation? Methods and Findings We conducted a key informant study on VMMC demand creation using purposive sampling to recruit seven people who provide technical assistance to government programs and manage budgets for VMMC demand creation. Key informants provided their views on the important elements of VMMC demand creation and the most effective funding allocations across different types of communication approaches (e.g., mass media, small media, outreach/mobilization). The key finding was the wide range of views, suggesting that a standard package of core demand creation elements would not be universally applicable. This underscored the importance of tailoring demand creation strategies and estimates to specific country contexts before estimating costs. The key informant interviews, supplemented by the researchers' field experience, identified these issues to be addressed in future costing exercises: variations in the cost of VMMC demand creation activities by country and program, decisions about the quality and comprehensiveness of programming, and lack of data on critical elements needed to “trigger the decision” among eligible men. Conclusions Based on this study's findings, we propose a seven-step methodological approach to estimate the cost of VMMC scale-up in a priority country, based on our key assumptions. However, further work is needed to better understand core components of a demand creation package and how to cost them. Notwithstanding the methodological challenges, estimating the cost of demand creation remains an essential element in deriving estimates of the total costs for VMMC scale-up in eastern and southern Africa. PMID:22140450

  19. 77 FR 49839 - IndexIQ Advisors LLC and IndexIQ Active ETF Trust; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... Amount (if any), for that day. The published Creation Basket will apply until a new Creation Basket is announced on the following Business Day, and there will be no intra-day changes to the Creation Basket... (``Shares'') redeemable in large aggregations only (``Creation Units''); (b) secondary market transactions...

  20. 8 CFR 264.2 - Application for creation of record of permanent residence.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Application for creation of record of... REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.2 Application for creation of... this chapter shall submit his/her application for creation of a record of lawful permanent residence on...

  1. 8 CFR 264.2 - Application for creation of record of permanent residence.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Application for creation of record of... REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.2 Application for creation of... this chapter shall submit his/her application for creation of a record of lawful permanent residence on...

  2. 8 CFR 264.2 - Application for creation of record of permanent residence.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Application for creation of record of... REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.2 Application for creation of... this chapter shall submit his/her application for creation of a record of lawful permanent residence on...

  3. 8 CFR 264.2 - Application for creation of record of permanent residence.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Application for creation of record of... REGULATIONS REGISTRATION AND FINGERPRINTING OF ALIENS IN THE UNITED STATES § 264.2 Application for creation of... this chapter shall submit his/her application for creation of a record of lawful permanent residence on...

  4. 49 CFR 1150.33 - Information to be contained in notice-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... that involve creation of Class III carriers. 1150.33 Section 1150.33 Transportation Other Regulations.... 10901 § 1150.33 Information to be contained in notice—transactions that involve creation of Class III...: § 1150.33 Information to be contained in notice—transactions that involve creation of Class III carriers...

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Yizhou, E-mail: yliu062@ucr.edu; Yin, Gen; Lake, Roger K., E-mail: rlake@ece.ucr.edu

    Single skyrmion creation and annihilation by spin waves in a crossbar geometry are theoretically analyzed. A critical spin-wave frequency is required both for the creation and the annihilation of a skyrmion. The minimum frequencies for creation and annihilation are similar, but the optimum frequency for creation is below the critical frequency for skyrmion annihilation. If a skyrmion already exists in the cross bar region, a spin wave below the critical frequency causes the skyrmion to circulate within the central region. A heat assisted creation process reduces the spin-wave frequency and amplitude required for creating a skyrmion. The effective field resultingmore » from the Dzyaloshinskii-Moriya interaction and the emergent field of the skyrmion acting on the spin wave drive the creation and annihilation processes.« less

  6. Sharpening the U-Th Chronometer: Progress and Outlook

    NASA Astrophysics Data System (ADS)

    McLean, N. M.; Condon, D. J.; Henderson, G. M.; Richards, D. A.; Noble, S.; Mason, A.

    2013-12-01

    Uranium is incorporated into a variety of natural materials when they form, including carbonates like speleothems and corals. The two most abundant naturally occurring uranium isotopes, 238U and 235U, decay to 206Pb and 207Pb over long timescales with half-lives of 4.5 and 0.7 billion years respectively, but transition through several intermediate daughter isotopes with shorter half-lives first. Fractionation between these daughter isotopes, including 234U, 230Th, and 231Pa, and their parent isotopes, followed by their time-dependent return to secular equilibrium over the course of up to ~800 kyr, forms the basis for U-series geochronology, and allows speleothems and corals to be precisely dated. These carbonates often additionally incorporate chemical and isotopic signatures (e.g., trace elements, δ18O and δ13C) from the environment in which they form, and thus are some of the best dated paleoclimate archives, offering clues about past and future conditions for life on Earth. Over the past decade, the analytical precision of U-series isotope measurements has improved dramatically, largely due to the steadily increasing sensitivity of multiple-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). Analytical uncertainties in U-Th dates now approach or are better than 0.1% (2σ), for instance ×100 years for a speleothem or coral that is 130 kyr old (Cheng et al., 2013). However, the accuracy of U-series dates also depends on the accuracy of tracer calibrations, reference solutions and data reduction protocols, which has not kept pace in many laboratories. This means that dates measured in different labs, while impressively precise, may not be directly comparable. To address issues of inter-laboratory bias and improve the accuracy and inter-comparability of U-Th dates, we have instigated work in three related directions. First, we report on the mixing of three synthetic U-Th age solutions, created by combining high-purity mono-isotopic solutions to mimic the isotopic composition of commonly analyzed materials. These age solutions will form the basis for an inter-laboratory comparison and serve as international reference materials for assessing long-term reproducibility. Second is the creation of several U-Th gravimetric solutions, which can be used to calibrate the mixed 229Th-236U×233U tracers used in the community without having to rely on materials assumed to be in secular equilibrium. Tracers calibrated against these solutions, and therefore U-Th dates measured with these tracers, will be fully metrologically traceable. Finally, we report progress on and important considerations in developing data reduction and uncertainty propagation protocols for calculating U-Th dates and constructing and interpreting U-Th age models. Reference: Cheng et al. (2013) EPSL 371-372, 82-91

  7. [Methodological approaches to the creation of healthy food].

    PubMed

    Kornen, N N; Viktorova, E P; Evdokimova, O V

    2015-01-01

    The substantiation of necessity of creation of healthy food products and their classification. Formulated methodological approaches to the creation of healthy food: enriched, functional and specialized purpose.

  8. 78 FR 32281 - ProShares Advisors LLC, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... 144A. \\5\\ Each Fund will sell and redeem Creation Units on any day the Fund is open for business... Balancing Amount (if any), for that day. The published Creation Basket will apply until a new Creation Basket is announced on the following Business Day, and there will be no intra-day changes to the Creation...

  9. 43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary or...

  10. 43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary or...

  11. 43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary or...

  12. 26 CFR 301.6048-1 - Returns as to creation of or transfers to certain foreign trusts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Returns as to creation of or transfers to... and Returns Returns and Records § 301.6048-1 Returns as to creation of or transfers to certain foreign trusts. For provisions relating to the requirement of returns as to creation of or transfers to certain...

  13. 26 CFR 301.6048-1 - Returns as to creation of or transfers to certain foreign trusts.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 18 2014-04-01 2014-04-01 false Returns as to creation of or transfers to... and Returns Returns and Records § 301.6048-1 Returns as to creation of or transfers to certain foreign trusts. For provisions relating to the requirement of returns as to creation of or transfers to certain...

  14. 20 CFR 631.30 - Designation or creation and functions of a State dislocated worker unit or office, and rapid...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Designation or creation and functions of a... TRAINING PARTNERSHIP ACT State Administration § 631.30 Designation or creation and functions of a State dislocated worker unit or office, and rapid response assistance. (a) Designation or creation of State...

  15. 26 CFR 301.6048-1 - Returns as to creation of or transfers to certain foreign trusts.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 18 2013-04-01 2013-04-01 false Returns as to creation of or transfers to... and Returns Returns and Records § 301.6048-1 Returns as to creation of or transfers to certain foreign trusts. For provisions relating to the requirement of returns as to creation of or transfers to certain...

  16. 43 CFR 3280.5 - May BLM require the modification of lease requirements in connection with the creation and...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... requirements in connection with the creation and operation of a unit agreement? 3280.5 Section 3280.5 Public... with the creation and operation of a unit agreement? (a) BLM may, with the consent of the lessees... connection with the creation and operation of any such unit agreement as BLM may consider necessary or...

  17. 20 CFR 631.30 - Designation or creation and functions of a State dislocated worker unit or office, and rapid...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Designation or creation and functions of a... TRAINING PARTNERSHIP ACT State Administration § 631.30 Designation or creation and functions of a State dislocated worker unit or office, and rapid response assistance. (a) Designation or creation of State...

  18. 26 CFR 301.6048-1 - Returns as to creation of or transfers to certain foreign trusts.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Returns as to creation of or transfers to... and Returns Returns and Records § 301.6048-1 Returns as to creation of or transfers to certain foreign trusts. For provisions relating to the requirement of returns as to creation of or transfers to certain...

  19. 26 CFR 301.6048-1 - Returns as to creation of or transfers to certain foreign trusts.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Returns as to creation of or transfers to... and Returns Returns and Records § 301.6048-1 Returns as to creation of or transfers to certain foreign trusts. For provisions relating to the requirement of returns as to creation of or transfers to certain...

  20. Nascent Entrepreneurship and the Developing Individual: Early Entrepreneurial Competence in Adolescence and Venture Creation Success during the Career

    ERIC Educational Resources Information Center

    Obschonka, Martin; Silbereisen, Rainer K.; Schmitt-Rodermund, Eva; Stuetzer, Michael

    2011-01-01

    What predicts a person's venture creation success over the course of the career, such as making progress in the venture creation process and multiple successful venture creations? Applying a life span approach of human development, this study examined the effect of early entrepreneurial competence in adolescence, which was gathered retrospectively…

  1. 'Ethos' Enabling Organisational Knowledge Creation

    NASA Astrophysics Data System (ADS)

    Matsudaira, Yoshito

    This paper examines knowledge creation in relation to improvements on the production line in the manufacturing department of Nissan Motor Company and aims to clarify embodied knowledge observed in the actions of organisational members who enable knowledge creation will be clarified. For that purpose, this study adopts an approach that adds a first, second, and third-person's viewpoint to the theory of knowledge creation. Embodied knowledge, observed in the actions of organisational members who enable knowledge creation, is the continued practice of 'ethos' (in Greek) founded in Nissan Production Way as an ethical basis. Ethos is knowledge (intangible) assets for knowledge creating companies. Substantiated analysis classifies ethos into three categories: the individual, team and organisation. This indicates the precise actions of the organisational members in each category during the knowledge creation process. This research will be successful in its role of showing the indispensability of ethos - the new concept of knowledge assets, which enables knowledge creation -for future knowledge-based management in the knowledge society.

  2. Anticancer substances of mushroom origin.

    PubMed

    Ivanova, T S; Krupodorova, T A; Barshteyn, V Y; Artamonova, A B; Shlyakhovenko, V A

    2014-06-01

    The present status of investigations about the anticancer activity which is inherent to medicinal mushrooms, as well as their biomedical potential and future prospects are discussed. Mushroom products and extracts possess promising immunomodulating and anticancer effects, so the main biologically active substances of mushrooms responsible for immunomodulation and direct cytoto-xicity toward cancer cell lines (including rarely mentioned groups of anticancer mushroom proteins), and the mechanisms of their antitumor action were analyzed. The existing to date clinical trials of mushroom substances are mentioned. Mushroom anticancer extracts, obtained by the different solvents, are outlined. Modern approaches of cancer treatment with implication of mushroom products, including DNA vaccinotherapy with mushroom immunomodulatory adjuvants, creation of prodrugs with mushroom lectins that can recognize glycoconjugates on the cancer cell surface, development of nanovectors etc. are discussed. The future prospects of mushroom anticancer substances application, including chemical modification of polysaccharides and terpenoids, gene engineering of proteins, and implementation of vaccines are reviewed.

  3. Biotin-independent strains of Escherichia coli for enhanced streptavidin production.

    PubMed

    Jeschek, Markus; Bahls, Maximilian O; Schneider, Veronika; Marlière, Philippe; Ward, Thomas R; Panke, Sven

    2017-03-01

    Biotin is an archetypal vitamin used as cofactor for carboxylation reactions found in all forms of life. However, biotin biosynthesis is an elaborate multi-enzymatic process and metabolically costly. Moreover, many industrially relevant organisms are incapable of biotin synthesis resulting in the requirement to supplement defined media. Here we describe the creation of biotin-independent strains of Escherichia coli and Corynebacterium glutamicum through installation of an optimized malonyl-CoA bypass, which re-routes natural fatty acid synthesis, rendering the previously essential vitamin completely obsolete. We utilize biotin-independent E. coli for the production of the high-value protein streptavidin which was hitherto restricted because of toxic effects due to biotin depletion. The engineered strain revealed significantly improved streptavidin production resulting in the highest titers and productivities reported for this protein to date. Copyright © 2017 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

  4. Allogeneic tumor cell vaccines

    PubMed Central

    Srivatsan, Sanjay; Patel, Jaina M; Bozeman, Erica N; Imasuen, Imade E; He, Sara; Daniels, Danielle; Selvaraj, Periasamy

    2014-01-01

    The high mortality rate associated with cancer and its resistance to conventional treatments such as radiation and chemotherapy has led to the investigation of a variety of anti-cancer immunotherapies. The development of novel immunotherapies has been bolstered by the discovery of tumor-associated antigens (TAAs), through gene sequencing and proteomics. One such immunotherapy employs established allogeneic human cancer cell lines to induce antitumor immunity in patients through TAA presentation. Allogeneic cancer immunotherapies are desirable in a clinical setting due to their ease of production and availability. This review aims to summarize clinical trials of allogeneic tumor immunotherapies in various cancer types. To date, clinical trials have shown limited success due potentially to extensive degrees of inter- and intra-tumoral heterogeneity found among cancer patients. However, these clinical results provide guidance for the rational design and creation of more effective allogeneic tumor immunotherapies for use as monotherapies or in combination with other therapies. PMID:24064957

  5. Allogeneic tumor cell vaccines: the promise and limitations in clinical trials.

    PubMed

    Srivatsan, Sanjay; Patel, Jaina M; Bozeman, Erica N; Imasuen, Imade E; He, Sara; Daniels, Danielle; Selvaraj, Periasamy

    2014-01-01

    The high mortality rate associated with cancer and its resistance to conventional treatments such as radiation and chemotherapy has led to the investigation of a variety of anti-cancer immunotherapies. The development of novel immunotherapies has been bolstered by the discovery of tumor-associated antigens (TAAs), through gene sequencing and proteomics. One such immunotherapy employs established allogeneic human cancer cell lines to induce antitumor immunity in patients through TAA presentation. Allogeneic cancer immunotherapies are desirable in a clinical setting due to their ease of production and availability. This review aims to summarize clinical trials of allogeneic tumor immunotherapies in various cancer types. To date, clinical trials have shown limited success due potentially to extensive degrees of inter- and intra-tumoral heterogeneity found among cancer patients. However, these clinical results provide guidance for the rational design and creation of more effective allogeneic tumor immunotherapies for use as monotherapies or in combination with other therapies.

  6. NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 9: Information intermediaries and the transfer of aerospace Scientific and Technical Information (STI): A report from the field

    NASA Technical Reports Server (NTRS)

    Eveland, J. D.; Pinelli, Thomas E.

    1991-01-01

    From the NASA/DOD survey data, there can be no way of inferring what strategy for knowledge transfer is best; indeed, given the fact that the respondents were all presumably well qualified professionals, the data tend to call into serious question the idea that any one model might meet the needs of more than a distinct minority of possible users. The evidence to date appears to reinforce the concept that different information environments take many different shapes, and interact with each other and with formal data transmission sources in many different and equally valuable ways. Any overall strategy for improving the effectiveness and efficiency of scientific and technical information sharing must take this divergence into account, and work toward the creation of systems that reinforce true interactive knowledge utilization rather than simply disseminating data.

  7. Medicare+Choice: what lies ahead?

    PubMed

    Layne, R Jeffrey

    2002-03-01

    Health plans have continued to exit the Medicare+Choice program in recent years, despite efforts of Congress and the Centers for Medicare and Medicaid Services (CMS) to reform the program. Congress and CMS therefore stand poised to make additional, substantial reforms to the program. CMS has proposed to consolidate its oversight of the program, extend the due date for Medicare+Choice plans to file their adjusted community rate proposals, revise risk-adjustment processes, streamline the marketing review process, enhance quality-improvement requirements, institute results based performance assessment audits, coordinate policy changes to coincide with contracting cycles, expand its fall advertising campaign for the program, provide better employer-based Medicare options for beneficiaries, and take steps to minimize beneficiary costs. Congressional leaders have proposed various legislative remedies to improve the program, including creation of an entirely new pricing structure for the program based on a competitive bidding process.

  8. The coming of age of artificial intelligence in medicine.

    PubMed

    Patel, Vimla L; Shortliffe, Edward H; Stefanelli, Mario; Szolovits, Peter; Berthold, Michael R; Bellazzi, Riccardo; Abu-Hanna, Ameen

    2009-05-01

    This paper is based on a panel discussion held at the Artificial Intelligence in Medicine Europe (AIME) conference in Amsterdam, The Netherlands, in July 2007. It had been more than 15 years since Edward Shortliffe gave a talk at AIME in which he characterized artificial intelligence (AI) in medicine as being in its "adolescence" (Shortliffe EH. The adolescence of AI in medicine: will the field come of age in the '90s? Artificial Intelligence in Medicine 1993;5:93-106). In this article, the discussants reflect on medical AI research during the subsequent years and characterize the maturity and influence that has been achieved to date. Participants focus on their personal areas of expertise, ranging from clinical decision-making, reasoning under uncertainty, and knowledge representation to systems integration, translational bioinformatics, and cognitive issues in both the modeling of expertise and the creation of acceptable systems.

  9. The coming revolution in personal care robotics: what does it mean for nurses?

    PubMed

    Sharts-Hopko, Nancy C

    2014-01-01

    The business sector provides regular reportage on the development of personal care robots to enable elders and people with disabilities to remain in their homes. Technology in this area is advancing rapidly in Asia, Europe, and North America. To date, the nursing literature has not addressed how nurses will assist these vulnerable populations in the selection and use of robotic technology or how robotics could effect nursing care and patient outcomes. This article provides an overview of development in the area of personal care robotics to address societal needs reflecting demographic trends. Selected relevant issues related to the human-robotic interface including ethical concerns are identified. Implications for nursing education and the delivery of nursing services are identified. Collaboration with engineers in the development of personal care robotic technology has the potential to contribute to the creation of products that optimally address the needs of elders and people with disabilities.

  10. Core competencies in the science and practice of knowledge translation: description of a Canadian strategic training initiative.

    PubMed

    Straus, Sharon E; Brouwers, Melissa; Johnson, David; Lavis, John N; Légaré, France; Majumdar, Sumit R; McKibbon, K Ann; Sales, Anne E; Stacey, Dawn; Klein, Gail; Grimshaw, Jeremy

    2011-12-09

    Globally, healthcare systems are attempting to optimize quality of care. This challenge has resulted in the development of implementation science or knowledge translation (KT) and the resulting need to build capacity in both the science and practice of KT. We are attempting to meet these challenges through the creation of a national training initiative in KT. We have identified core competencies in this field and have developed a series of educational courses and materials for three training streams. We report the outline for this approach and the progress to date. We have prepared a strategy to develop, implement, and evaluate a national training initiative to build capacity in the science and practice of KT. Ultimately through this initiative, we hope to meet the capacity demand for KT researchers and practitioners in Canada that will lead to improved care and a strengthened healthcare system.

  11. Core competencies in the science and practice of knowledge translation: description of a Canadian strategic training initiative

    PubMed Central

    2011-01-01

    Background Globally, healthcare systems are attempting to optimize quality of care. This challenge has resulted in the development of implementation science or knowledge translation (KT) and the resulting need to build capacity in both the science and practice of KT. Findings We are attempting to meet these challenges through the creation of a national training initiative in KT. We have identified core competencies in this field and have developed a series of educational courses and materials for three training streams. We report the outline for this approach and the progress to date. Conclusions We have prepared a strategy to develop, implement, and evaluate a national training initiative to build capacity in the science and practice of KT. Ultimately through this initiative, we hope to meet the capacity demand for KT researchers and practitioners in Canada that will lead to improved care and a strengthened healthcare system. PMID:22152223

  12. Plant Biodiversity Change Across Scales During the Anthropocene.

    PubMed

    Vellend, Mark; Baeten, Lander; Becker-Scarpitta, Antoine; Boucher-Lalonde, Véronique; McCune, Jenny L; Messier, Julie; Myers-Smith, Isla H; Sax, Dov F

    2017-04-28

    Plant communities have undergone dramatic changes in recent centuries, although not all such changes fit with the dominant biodiversity-crisis narrative used to describe them. At the global scale, future declines in plant species diversity are highly likely given habitat conversion in the tropics, although few extinctions have been documented for the Anthropocene to date (<0.1%). Nonnative species introductions have greatly increased plant species richness in many regions of the world at the same time that they have led to the creation of new hybrid polyploid species by bringing previously isolated congeners into close contact. At the local scale, conversion of primary vegetation to agriculture has decreased plant diversity, whereas other drivers of change-e.g., climate warming, habitat fragmentation, and nitrogen deposition-have highly context-dependent effects, resulting in a distribution of temporal trends with a mean close to zero. These results prompt a reassessment of how conservation goals are defined and justified.

  13. Familiarizing Students with the Basics of a Smartphone's Internal Sensors

    NASA Astrophysics Data System (ADS)

    Countryman, Colleen Lanz

    2014-12-01

    The Physics Teacher's "iPhysicsLabs" column has been dedicated to the implementation of smartphones in instructional physics labs as data collection devices. In order to understand any data set, however, one should first understand how it is obtained. This concern regarding the inclusion of smartphones in lab activities has arisen in response to the creation of this column1 as well as to a paper in a recent issue of Physics Today.2 The majority of the labs featured in the "iPhysicsLabs" column to date make use of the internal accelerometer, common to nearly all smartphones on the market today. In order to glean meaningful conclusions from their data, students should first understand how the sensor works, as was pointed out in the first article to be featured in that column.3 We attempt to elucidate this "iBlackBox" using a simple ball-and-spring model.

  14. Creationism & Climate Change (Invited)

    NASA Astrophysics Data System (ADS)

    Newton, S.

    2009-12-01

    Although creationists focus on the biological sciences, recently creationists have also expanded their attacks to include the earth sciences, especially on the topic of climate change. The creationist effort to deny climate change, in addition to evolution and radiometric dating, is part of a broader denial of the methodology and validity of science itself. Creationist misinformation can pose a serious problem for science educators, who are further hindered by the poor treatment of the earth sciences and climate change in state science standards. Recent changes to Texas’ science standards, for example, require that students learn “different views on the existence of global warming.” Because of Texas’ large influence on the national textbook market, textbooks presenting non-scientific “different views” about climate change—or simply omitting the subject entirely because of the alleged “controversy”—could become part of K-12 classrooms across the country.

  15. Development of moral character in the People's Republic of China: Some implications for educators

    NASA Astrophysics Data System (ADS)

    Hu, Xiaolu; Korllos, Thomas S.

    1995-01-01

    This paper presents data gathered from a sample of mainland Chinese university students to test some assumptions about social control theory. According to theory dating back to Durkheim, the most important mechanism for exerting social control in a population is the process of development of moral character. While political socialization is the dominant influence in the People's Republic of China, the family, the media, and particularly the educational system are used to play important roles in the creation of model members of that society. Findings from questions on morality, modernity and the influence of schooling indicate the formation of strong moral views and the apparent absorption of state values. While the limitations of the data do not permit wider generalization, the results suggest the success of the state in transferring central values to at the least the younger age group.

  16. Mesenchymal stem cells: immune evasive, not immune privileged

    PubMed Central

    Ankrum, James A.; Ong, Joon Faii; Karp, Jeffrey M.

    2014-01-01

    The diverse immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) may be exploited for treatment of a multitude of inflammatory conditions. MSCs have long been reported to be hypoimmunogenic or ‘immune privileged’; this property is thought to enable MSC transplantation across major histocompatibility barriers and the creation of off-the-shelf therapies consisting of MSCs grown in culture. However, recent studies describing generation of antibodies against and immune rejection of allogeneic donor MSCs suggest that MSCs may not actually be immune privileged. Nevertheless, whether rejection of donor MSCs influences the efficacy of allogeneic MSC therapies is not known, and no definitive clinical advantage of autologous MSCs over allogeneic MSCs has been demonstrated to date. Although MSCs may exert therapeutic function through a brief ‘hit and run’ mechanism, protecting MSCs from immune detection and prolonging their persistence in vivo may improve clinical outcomes and prevent patient sensitization toward donor antigens. PMID:24561556

  17. Bioinspired Nanoscale Materials for Biomedical and Energy Applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bhattacharya, Priyanka; Du, Dan; Lin, Yuehe

    2014-05-01

    The demand of green, affordable and environmentally sustainable materials has encouraged scientists in different fields to draw inspiration from nature in developing materials with unique properties such as miniaturization, hierarchical organization, and adaptability. Together with the exceptional properties of nanomaterials, over the past century, the field of bioinspired nanomaterials has taken huge leaps. While on one hand, the sophistication of hierarchical structures endow biological systems with multifunctionality, the synthetic control on the creation of nanomaterials enables the design of materials with specific functionalities. The aim of this review is to provide a comprehensive, up-to-date overview of the field of bioinspiredmore » nanomaterials, which we have broadly categorized into biotemplates and biomimics. We will discuss the application of bioinspired nanomaterials as biotemplates in catalysis, nanomedicine, immunoassays and in energy, drawing attention to novel materials such as protein cages. Further, the applications of bioinspired materials in tissue engineering and biomineralization will also be discussed.« less

  18. Undergraduate Education with the WIYN 0.9-m Telescope

    NASA Astrophysics Data System (ADS)

    Pilachowski, Catherine A.

    2017-01-01

    Several models have been explored at Indiana University Bloomington for undergraduate student engagement in astronomy using the WIYN 0.9-m telescope at Kitt Peak. These models include individual student research projects using the telescope, student observations as part of an observational techniques course for majors, and enrichment activities for non-science majors in general education courses. Where possible, we arrange for students to travel to the telescope. More often, we are able to use simple online tools such as Skype and VNC viewers to give students an authentic observing experience. Experiences with the telescope motivate students to learn basic content in astronomy, including the celestial sphere, the electromagnetic spectrum, telescopes and detectors, the variety of astronomical objects, date reduction processes, image analysis, and color image creation and appreciation. The WIYN 0.9-m telescope is an essential tool for our program at all levels of undergraduate education

  19. Scientific Services on the Cloud

    NASA Astrophysics Data System (ADS)

    Chapman, David; Joshi, Karuna P.; Yesha, Yelena; Halem, Milt; Yesha, Yaacov; Nguyen, Phuong

    Scientific Computing was one of the first every applications for parallel and distributed computation. To this date, scientific applications remain some of the most compute intensive, and have inspired creation of petaflop compute infrastructure such as the Oak Ridge Jaguar and Los Alamos RoadRunner. Large dedicated hardware infrastructure has become both a blessing and a curse to the scientific community. Scientists are interested in cloud computing for much the same reason as businesses and other professionals. The hardware is provided, maintained, and administrated by a third party. Software abstraction and virtualization provide reliability, and fault tolerance. Graduated fees allow for multi-scale prototyping and execution. Cloud computing resources are only a few clicks away, and by far the easiest high performance distributed platform to gain access to. There may still be dedicated infrastructure for ultra-scale science, but the cloud can easily play a major part of the scientific computing initiative.

  20. Attitudes and intentions of off-highway vehicle riders toward trail use: implications for forest managers

    USGS Publications Warehouse

    Kuehn, D.M.; D'Luhosch, P. D.; Luzadis, V.A.; Malmsheimer, R.W.; Schuster, R.M.

    2011-01-01

    Management of off-highway vehicles (OHV) in public forest areas requires up-to-date information about the attitudes and intentions of OHV riders toward trail use. A survey of 811 members of the New England Trail Riders Association was conducted in fall 2007; 380 questionnaires were completed and returned. Descriptive statistics and regressions were used to identify relationships between OHV rider attitudes, management preferences, and intentions toward two trail use-related behaviors (i.e., illegal use of trails by OHVs and the creation and/or use of unauthorized trails by OHV riders). Results reveal that the average responding association member has a negative attitude toward the two depreciative behaviors, intends to ride OHVs legally, and slightly prefers indirect over direct forms of management. Significant relationships between intentions and both attitudes and management preferences are identified. Policy and management implications and strategies are discussed. ?? 2011 by the Society of American Foresters.

  1. International jurisprudence on trade and environmental health: one step forward, two steps back?

    PubMed

    Timmermans, Karin

    2008-01-01

    Since the creation of the World Trade Organization (WTO), there has been considerable debate regarding the impact of its rules on public health. By contrast, the role of the WTO dispute settlement mechanism has received little attention, even though the bodies responsible for settling disputes are the ultimate interpreters of WTO rules and agreements. To date, three WTO disputes that relate to occupational and/or environmental health have been fully litigated. A review of the decisions and reasoning in these cases indicates that WTO jurisprudence is evolving, as Panels and the Appellate Body try--with varying degrees of success--to balance countries' rights and obligations under international trade agreements with their right to protect occupational and environmental health. Disputes between nations can have an impact beyond the parties concerned, and raise questions about the relationship between trade agreements and other international agreements, especially multilateral environmental agreements (MEAs).

  2. A Bibliometric History of the Journal of Psychology Between 1936 and 2015.

    PubMed

    Tur-Porcar, Ana; Mas-Tur, Alicia; Merigó, José M; Roig-Tierno, Norat; Watt, John

    2018-05-19

    The Journal of Psychology: Interdisciplinary and Applied is a leading international journal in psychology dating back to 1935. This study examines its publications since its creation utilizing a bibliometric analysis. The primary objective is to provide a complete overview of the key factors affecting the journal. This analysis includes such key issues as the publication and citation structure of the journal, its most cited articles, and the leading authors, institutions, and countries referenced in the journal. The work uses the Scopus database to classify the bibliographic material. Additionally, the analysis provides a graphical mapping of the bibliographic data by using visualization of similarities viewer software. This software uses several bibliometric techniques including co-citation, bibliographic coupling and co-occurrence of keywords. The Journal of Psychology is strongly connected to most of the current leading journals in psychology, and currently has a 5-year impact factor of 1.77 (Thomson Reuters, 2015 Journal Citation Reports).

  3. The Coming of Age of Artificial Intelligence in Medicine*

    PubMed Central

    Patel, Vimla L.; Shortliffe, Edward H.; Stefanelli, Mario; Szolovits, Peter; Berthold, Michael R.; Bellazzi, Riccardo; Abu-Hanna, Ameen

    2009-01-01

    Summary This paper is based on a panel discussion held at the Artificial Intelligence in Medicine Europe (AIME) conference in Amsterdam, The Netherlands, in July 2007. It had been more than 15 years since Edward Shortliffe gave a talk at AIME in which he characterized artificial intelligence (AI) in medicine as being in its “adolescence” (Shortliffe EH. The adolescence of AI in medicine: Will the field come of age in the ‘90s? Artificial Intelligence in Medicine 1993; 5:93–106). In this article, the discussants reflect on medical AI research during the subsequent years and attempt to characterize the maturity and influence that has been achieved to date. Participants focus on their personal areas of expertise, ranging from clinical decision making, reasoning under uncertainty, and knowledge representation to systems integration, translational bioinformatics, and cognitive issues in both the modeling of expertise and the creation of acceptable systems. PMID:18790621

  4. Validation list no. 110. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2006-07-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  5. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2005-01-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  6. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2005-03-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  7. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2008-09-01

    The purpose of this announcement is to effect the valid publication of the following effectively published new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  8. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2007-07-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  9. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    Euzéby, Jean

    2008-07-01

    The purpose of this announcement is to effect the valid publication of the following effectively published new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  10. Validation list no. 98. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2004-07-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  11. Validation list no. 113. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2007-01-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  12. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2008-01-01

    The purpose of this announcement is to effect the valid publication of the following effectively published new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  13. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2004-05-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  14. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2004-11-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  15. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    Euzéby, Jean

    2007-05-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  16. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2005-09-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  17. Validation list no. 114. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2007-03-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  18. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2004-03-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  19. Validation List no. 117. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    Euzéby, Jean

    2007-09-01

    The purpose of this announcement is to effect the valid publication of the following effectively published new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  20. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    Euzéby, Jean

    2005-05-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  1. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2005-07-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  2. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2004-01-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  3. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    Euzéby, Jean

    2008-03-01

    The purpose of this announcement is to effect the valid publication of the following effectively published new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  4. Validation of publication of new names and new combinations previously effectively published outside the IJSEM.

    PubMed

    2004-09-01

    The purpose of this announcement is to effect the valid publication of the following new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  5. List of new names and new combinations previously effectively, but not validly, published.

    PubMed

    2008-05-01

    The purpose of this announcement is to effect the valid publication of the following effectively published new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should send three copies of the pertinent reprint or photocopies thereof, or an electronic copy of the published paper, to the IJSEM Editorial Office for confirmation that all of the other requirements for valid publication have been met. It is also a requirement of IJSEM and the ICSP that authors of new species, new subspecies and new combinations provide evidence that types are deposited in two recognized culture collections in two different countries (i.e. documents certifying deposition and availability of type strains). It should be noted that the date of valid publication of these new names and combinations is the date of publication of this list, not the date of the original publication of the names and combinations. The authors of the new names and combinations are as given below, and these authors' names will be included in the author index of the present issue and in the volume author index. Inclusion of a name on these lists validates the publication of the name and thereby makes it available in bacteriological nomenclature. The inclusion of a name on this list is not to be construed as taxonomic acceptance of the taxon to which the name is applied. Indeed, some of these names may, in time, be shown to be synonyms, or the organisms may be transferred to another genus, thus necessitating the creation of a new combination.

  6. 77 FR 37362 - Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ...] Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a Public Safety... public safety answering points (PSAPs) as required by the ``Middle Class Tax Relief and Job Creation Act... Objectives of, the Proposed Rules 21. The ``Middle Class Tax Relief and Job Creation Act of 2012'' requires...

  7. Comparison of post-creation procedures and costs between surgical and an endovascular approach to arteriovenous fistula creation.

    PubMed

    Yang, Shuo; Lok, Charmaine; Arnold, Renee; Rajan, Dheeraj; Glickman, Marc

    2017-03-28

    Due to early and late failures that may occur with surgically created hemodialysis arteriovenous fistulas (SAVF), post-creation procedures are commonly required to facilitate AVF maturation and maintain patency. This study compared AVF post-creation procedures and their associated costs in patients with SAVF to patients with a new endovascularly created AVF (endoAVF). A 5% random sample from Medicare Standard Analytical Files was abstracted to determine post-creation procedures and associated costs for SAVF created from 2011 to 2013. Medicare enrollment during the 6 months prior to and after the AVF creation was required. Patients' follow-up inpatient, outpatient, and physician claims were used to identify post-creation procedures and to estimate average procedure costs. Comparative procedural information on endoAVF was obtained from the Novel Endovascular Access Trial (NEAT). Of 3764 Medicare SAVF patients, 60 successfully matched to endoAVF patients using 1:1 propensity score matching of baseline demographic and clinical characteristics. The total post-creation procedural event rate within 1 year was lower for endoAVF patients (0.59 per patient-year) compared to the matched SAVF cohort (3.43 per patient-year; p<0.05). In the endoAVF cohort, event rates of angioplasty, thrombectomy, revision, catheter placement, subsequent arteriovenous graft (AVG), new SAVF, and vascular access-related infection were all significantly lower than in the SAVF cohort. The average first year cost per patient-year associated with post-creation procedures was estimated at US$11,240 USD lower for endoAVF than for SAVF. Compared to patients with SAVF, patients with endoAVF required fewer post-creation procedures and had lower associated mean costs within the first year.

  8. Automated CD-SEM recipe creation technology for mass production using CAD data

    NASA Astrophysics Data System (ADS)

    Kawahara, Toshikazu; Yoshida, Masamichi; Tanaka, Masashi; Ido, Sanyu; Nakano, Hiroyuki; Adachi, Naokaka; Abe, Yuichi; Nagatomo, Wataru

    2011-03-01

    Critical Dimension Scanning Electron Microscope (CD-SEM) recipe creation needs sample preparation necessary for matching pattern registration, and recipe creation on CD-SEM using the sample, which hinders the reduction in test production cost and time in semiconductor manufacturing factories. From the perspective of cost reduction and improvement of the test production efficiency, automated CD-SEM recipe creation without the sample preparation and the manual operation has been important in the production lines. For the automated CD-SEM recipe creation, we have introduced RecipeDirector (RD) that enables the recipe creation by using Computer-Aided Design (CAD) data and text data that includes measurement information. We have developed a system that automatically creates the CAD data and the text data necessary for the recipe creation on RD; and, for the elimination of the manual operation, we have enhanced RD so that all measurement information can be specified in the text data. As a result, we have established an automated CD-SEM recipe creation system without the sample preparation and the manual operation. For the introduction of the CD-SEM recipe creation system using RD to the production lines, the accuracy of the pattern matching was an issue. The shape of design templates for the matching created from the CAD data was different from that of SEM images in vision. Thus, a development of robust pattern matching algorithm that considers the shape difference was needed. The addition of image processing of the templates for the matching and shape processing of the CAD patterns in the lower layer has enabled the robust pattern matching. This paper describes the automated CD-SEM recipe creation technology for the production lines without the sample preparation and the manual operation using RD applied in Sony Semiconductor Kyusyu Corporation Kumamoto Technology Center (SCK Corporation Kumamoto TEC).

  9. Is the creation of artificial life morally significant?

    PubMed Central

    Douglas, Thomas; Powell, Russell; Savulescu, Julian

    2013-01-01

    In 2010, the Venter lab announced that it had created the first bacterium with an entirely synthetic genome. This was reported to be the first instance of ‘artificial life,’ and in the ethical and policy discussions that followed it was widely assumed that the creation of artificial life is in itself morally significant. We cast doubt on this assumption. First we offer an account of the creation of artificial life that distinguishes this from the derivation of organisms from existing life and clarify what we mean in asking whether the creation of artificial life has moral significance. We then articulate and evaluate three attempts to establish that the creation of artificial life is morally significant. These appeal to (1) the claim that the creation of artificial life involves playing God, as expressed in three distinct formulations; (2) the claim that the creation of artificial life will encourage reductionist attitudes toward the living world that undermine the special moral value accorded to life; and (3) the worry that artificial organisms will have an uncertain functional status and consequently an uncertain moral status. We argue that all three attempts to ground the moral significance of the creation of artificial life fail, because none of them establishes that the creation of artificial life is morally problematic in a way that the derivation of organisms from existing life forms is not. We conclude that the decisive moral consideration is not how life is created but what non-genealogical properties it possesses. PMID:23810562

  10. The Effect of Active Creation on Psychological Health: A Feasibility Study on (Therapeutic) Mechanisms

    PubMed Central

    Lange, Gudrun; Leonhart, Rainer; Gruber, Harald

    2018-01-01

    Creation is an important part of many interventions in creative arts therapies (art, music, dance, and drama therapy). This active part of art-making in arts therapies has not yet been closely investigated. The present study commits to this field of research using a mixed-methods design to investigate the effects of active creation on health-related psychological outcomes. In an artistic inquiry within an experimental design, N = 44 participants engaged in active art-making for eight minutes in the presence of the researcher (first author) with a choice of artistic materials: paper and colors for drawing and writing, musical instruments, space for moving or performing. Before and after the creation, participants completed a well-being, a self-efficacy and an experience of creation scale, and in addition found their own words to express the experiences during the activity. We hypothesized that the experience of empowerment, freedom, impact, and creativity (Experience of Creation Scale) mediates the positive effect of active creation on the outcomes of self-efficacy and well-being, and evaluated this assumption with a mediation analysis. Results suggest that the effect of active creation on both self-efficacy and well-being is significantly mediated by the Experience of Creation Scale. This article focuses on the quantitative side of the investigation. During the process, qualitative and quantitative results were triangulated for a more valid evaluation and jointly contribute to the emerging theory frame of embodied aesthetics. PMID:29439541

  11. Creation of sidewall aneurysm in rabbits: aneurysm patency and growth follow-up.

    PubMed

    Ding, Yong Hong; Tieu, Tai; Kallmes, David F

    2014-01-01

    To explore the patency and growth of surgical sidewall aneurysms in rabbits. Forty sidewall aneurysms were created in the right common carotid artery (RCCA). Intravenous digital subtraction angiography (DSA) through the ear vein was performed immediately after creation. Three weeks later, intra-arterial DSA through the femoral artery was performed. Aneurysm sizes (neck, width, height and volume) were measured and calculated immediately after creation and 3 weeks later. Aneurysm patency after creation was evaluated. Differences in aneurysm sizes immediately after creation and 3 weeks later were compared using the Student's t test. Aneurysms and the parent artery remained patent in 38 (95%) of the 40 rabbits 3 weeks after creation. Two other rabbits (5%) showed aneurysm occlusion. There was a significant difference in aneurysm neck size 3 weeks after creation (3.6±0.9 mm vs 2.4±0.4 mm, p<0.0001). The aneurysm became wider 3 weeks later (5.8±1.5 mm vs 4.3±1.2 mm, p<0.0001). Aneurysm length was also larger than immediately after creation (6.1±1.3 mm vs 4.3±1.4 mm, p<0.0001). The aneurysm volume was larger than that created immediately (127.5±89.4 mm(3) vs 51.0±34.9 mm(3), p<0.0001). The patency rate of sidewall aneurysms in rabbits is high. The aneurysm keeps growing for at least 3 weeks after creation.

  12. Is the creation of artificial life morally significant?

    PubMed

    Douglas, Thomas; Powell, Russell; Savulescu, Julian

    2013-12-01

    In 2010, the Venter lab announced that it had created the first bacterium with an entirely synthetic genome. This was reported to be the first instance of 'artificial life,' and in the ethical and policy discussions that followed it was widely assumed that the creation of artificial life is in itself morally significant. We cast doubt on this assumption. First we offer an account of the creation of artificial life that distinguishes this from the derivation of organisms from existing life and clarify what we mean in asking whether the creation of artificial life has moral significance. We then articulate and evaluate three attempts to establish that the creation of artificial life is morally significant. These appeal to (1) the claim that the creation of artificial life involves playing God, as expressed in three distinct formulations; (2) the claim that the creation of artificial life will encourage reductionist attitudes toward the living world that undermine the special moral value accorded to life; and (3) the worry that artificial organisms will have an uncertain functional status and consequently an uncertain moral status. We argue that all three attempts to ground the moral significance of the creation of artificial life fail, because none of them establishes that the creation of artificial life is morally problematic in a way that the derivation of organisms from existing life forms is not. We conclude that the decisive moral consideration is not how life is created but what non-genealogical properties it possesses. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. The Effect of Active Creation on Psychological Health: A Feasibility Study on (Therapeutic) Mechanisms.

    PubMed

    Lange, Gudrun; Leonhart, Rainer; Gruber, Harald; Koch, Sabine C

    2018-02-12

    Creation is an important part of many interventions in creative arts therapies (art, music, dance, and drama therapy). This active part of art-making in arts therapies has not yet been closely investigated. The present study commits to this field of research using a mixed-methods design to investigate the effects of active creation on health-related psychological outcomes. In an artistic inquiry within an experimental design, N = 44 participants engaged in active art-making for eight minutes in the presence of the researcher (first author) with a choice of artistic materials: paper and colors for drawing and writing, musical instruments, space for moving or performing. Before and after the creation, participants completed a well-being, a self-efficacy and an experience of creation scale, and in addition found their own words to express the experiences during the activity. We hypothesized that the experience of empowerment, freedom, impact, and creativity (Experience of Creation Scale) mediates the positive effect of active creation on the outcomes of self-efficacy and well-being, and evaluated this assumption with a mediation analysis. Results suggest that the effect of active creation on both self-efficacy and well-being is significantly mediated by the Experience of Creation Scale. This article focuses on the quantitative side of the investigation. During the process, qualitative and quantitative results were triangulated for a more valid evaluation and jointly contribute to the emerging theory frame of embodied aesthetics.

  14. Money creation process in a random redistribution model

    NASA Astrophysics Data System (ADS)

    Chen, Siyan; Wang, Yougui; Li, Keqiang; Wu, Jinshan

    2014-01-01

    In this paper, the dynamical process of money creation in a random exchange model with debt is investigated. The money creation kinetics are analyzed by both the money-transfer matrix method and the diffusion method. From both approaches, we attain the same conclusion: the source of money creation in the case of random exchange is the agents with neither money nor debt. These analytical results are demonstrated by computer simulations.

  15. More Stable Ties or Better Structure? An Examination of the Impact of Co-author Network on Team Knowledge Creation

    PubMed Central

    Li, Mingze; Zhuang, Xiaoli; Liu, Wenxing; Zhang, Pengcheng

    2017-01-01

    This study aims to explore the influence of co-author network on team knowledge creation. Integrating the two traditional perspectives of network relationship and network structure, we examine the direct and interactive effects of tie stability and structural holes on team knowledge creation. Tracking scientific articles published by 111 scholars in the research field of human resource management from the top 8 American universities, we analyze scholars’ scientific co-author networks. The result indicates that tie stability changes the teams’ information processing modes and, when graphed, results in an inverted U-shape relationship between tie stability and team knowledge creation. Moreover, structural holes in co-author network are proved to be harmful to team knowledge sharing and diffusion, thereby impeding team knowledge creation. Also, tie stability and structural hole interactively influence team knowledge creation. When the number of structural hole is low in the co-author network, the graphical representation of the relationship between tie stability and team knowledge creation tends to be a more distinct U-shape. PMID:28993744

  16. More Stable Ties or Better Structure? An Examination of the Impact of Co-author Network on Team Knowledge Creation.

    PubMed

    Li, Mingze; Zhuang, Xiaoli; Liu, Wenxing; Zhang, Pengcheng

    2017-01-01

    This study aims to explore the influence of co-author network on team knowledge creation. Integrating the two traditional perspectives of network relationship and network structure, we examine the direct and interactive effects of tie stability and structural holes on team knowledge creation. Tracking scientific articles published by 111 scholars in the research field of human resource management from the top 8 American universities, we analyze scholars' scientific co-author networks. The result indicates that tie stability changes the teams' information processing modes and, when graphed, results in an inverted U-shape relationship between tie stability and team knowledge creation. Moreover, structural holes in co-author network are proved to be harmful to team knowledge sharing and diffusion, thereby impeding team knowledge creation. Also, tie stability and structural hole interactively influence team knowledge creation. When the number of structural hole is low in the co-author network, the graphical representation of the relationship between tie stability and team knowledge creation tends to be a more distinct U-shape.

  17. Play it forward! A community-based participatory research approach to childhood obesity prevention.

    PubMed

    Berge, Jerica M; Jin, Seok Won; Hanson, Carrie; Doty, Jennifer; Jagaraj, Kimberly; Braaten, Kent; Doherty, William J

    2016-03-01

    To date there has been limited success with childhood obesity prevention interventions. This may be due in part, to the challenge of reaching and engaging parents in interventions. The current study used a community-based participatory research (CBPR) approach to engage parents in cocreating and pilot testing a childhood obesity prevention intervention. Because CBPR approaches to childhood obesity prevention are new, this study aims to detail the creation, including the formation of the citizen action group (CAG), and implementation of a childhood obesity prevention intervention using CBPR methods. A CBPR approach was used to recruit community members to partner with university researchers in the CAG (n = 12) to create and implement the Play It Forward! childhood obesity intervention. The intervention creation and implementation took 2 years. During Year 1 (2011-2012), the CAG carried out a community needs and resources assessment and designed a community-based and family focused childhood obesity prevention intervention. During Year 2 (2012-2013), the CAG implemented the intervention and conducted an evaluation. Families (n = 50; 25 experimental/25 control group) with children ages 6-12 years participated in Play It Forward! Feasibility and process evaluation data suggested that the intervention was highly feasible and participants in both the CAG and intervention were highly satisfied. Specifically, over half of the families attended 75% of the Play It Forward! events and 33% of families attended all the events. Equal collaboration between parents and academic researchers to address childhood obesity may be a promising approach that merits further testing. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  18. Iterative co-creation for improved hand hygiene and aseptic techniques in the operating room: experiences from the safe hands study.

    PubMed

    Erichsen Andersson, Annette; Frödin, Maria; Dellenborg, Lisen; Wallin, Lars; Hök, Jesper; Gillespie, Brigid M; Wikström, Ewa

    2018-01-04

    Hand hygiene and aseptic techniques are essential preventives in combating hospital-acquired infections. However, implementation of these strategies in the operating room remains suboptimal. There is a paucity of intervention studies providing detailed information on effective methods for change. This study aimed to evaluate the process of implementing a theory-driven knowledge translation program for improved use of hand hygiene and aseptic techniques in the operating room. The study was set in an operating department of a university hospital. The intervention was underpinned by theories on organizational learning, culture and person centeredness. Qualitative process data were collected via participant observations and analyzed using a thematic approach. Doubts that hand-hygiene practices are effective in preventing hospital acquired infections, strong boundaries and distrust between professional groups and a lack of psychological safety were identified as barriers towards change. Facilitated interprofessional dialogue and learning in "safe spaces" worked as mechanisms for motivation and engagement. Allowing for the free expression of different opinions, doubts and viewing resistance as a natural part of any change was effective in engaging all professional categories in co-creation of clinical relevant solutions to improve hand hygiene. Enabling nurses and physicians to think and talk differently about hospital acquired infections and hand hygiene requires a shift from the concept of one-way directed compliance towards change and learning as the result of a participatory and meaning-making process. The present study is a part of the Safe Hands project, and is registered with ClinicalTrials.gov (ID: NCT02983136 ). Date of registration 2016/11/28, retrospectively registered.

  19. Hybridization in a warmer world

    PubMed Central

    Chunco, Amanda J

    2014-01-01

    Climate change is profoundly affecting the evolutionary trajectory of individual species and ecological communities, in part through the creation of novel species assemblages. How climate change will influence competitive interactions has been an active area of research. Far less attention, however, has been given to altered reproductive interactions. Yet, reproductive interactions between formerly isolated species are inevitable as populations shift geographically and temporally as a result of climate change, potentially resulting in introgression, speciation, or even extinction. The susceptibility of hybridization rates to anthropogenic disturbance was first recognized in the 1930s. To date, work on anthropogenically mediated hybridization has focused primarily on either physical habitat disturbance or species invasion. Here, I review recent literature on hybridization to identify how ecological responses to climate change will increase the likelihood of hybridization via the dissolution of species barriers maintained by habitat, time, or behavior. Using this literature, I identify several cases where novel hybrid zones have recently formed, likely as a result of changing climate. Future research should focus on identifying areas and taxonomic groups where reproductive species interactions are most likely to be influenced by climate change. Furthermore, a better understanding of the evolutionary consequences of climate-mediated secondary contact is urgently needed. Paradoxically, hybridization is both a major conservation concern and an important source of novel genetic and phenotypic variation. Hybridization may therefore both contribute to increasing rates of extinction and stimulate the creation of novel phenotypes that will speed adaptation to novel climates. Predicting which result will occur following secondary contact will be an important contribution to conservation for many species. PMID:24963394

  20. Metadata Wizard: an easy-to-use tool for creating FGDC-CSDGM metadata for geospatial datasets in ESRI ArcGIS Desktop

    USGS Publications Warehouse

    Ignizio, Drew A.; O'Donnell, Michael S.; Talbert, Colin B.

    2014-01-01

    Creating compliant metadata for scientific data products is mandated for all federal Geographic Information Systems professionals and is a best practice for members of the geospatial data community. However, the complexity of the The Federal Geographic Data Committee’s Content Standards for Digital Geospatial Metadata, the limited availability of easy-to-use tools, and recent changes in the ESRI software environment continue to make metadata creation a challenge. Staff at the U.S. Geological Survey Fort Collins Science Center have developed a Python toolbox for ESRI ArcDesktop to facilitate a semi-automated workflow to create and update metadata records in ESRI’s 10.x software. The U.S. Geological Survey Metadata Wizard tool automatically populates several metadata elements: the spatial reference, spatial extent, geospatial presentation format, vector feature count or raster column/row count, native system/processing environment, and the metadata creation date. Once the software auto-populates these elements, users can easily add attribute definitions and other relevant information in a simple Graphical User Interface. The tool, which offers a simple design free of esoteric metadata language, has the potential to save many government and non-government organizations a significant amount of time and costs by facilitating the development of The Federal Geographic Data Committee’s Content Standards for Digital Geospatial Metadata compliant metadata for ESRI software users. A working version of the tool is now available for ESRI ArcDesktop, version 10.0, 10.1, and 10.2 (downloadable at http:/www.sciencebase.gov/metadatawizard).

  1. Knowledge-Based Transformational Synthesis of Efficient Structures for Concurrent Computation.

    DTIC Science & Technology

    1985-09-30

    this wire network to a smaller wire network , creation of subnetworks to replace an overly-broad fanout network , virtualization which is the creation of...dependencies among the values they contain, reduction of this wire network to a smaller wire network , " creation of subnetworks to replace an overly-broad...fanout network , "rtualization which is the creation of additional array elements and processors to reflect the internal enumera- -4 tions that

  2. Genera of the human lineage

    PubMed Central

    Cela-Conde, Camilo J.; Ayala, Francisco J.

    2003-01-01

    Human fossils dated between 3.5 and nearly 7 million years old discovered during the last 8 years have been assigned to as many as four new genera of the family Hominidae: Ardipithecus, Orrorin, Kenyanthropus, and Sahelanthropus. These specimens are described as having morphological traits that justify placing them in the family Hominidae while creating a new genus for the classification of each. The discovery of these fossils pushed backward by >2 million years the date of the oldest hominids known. Only two or three hominid genera, Australopithecus, Paranthropus, and Homo, had been previously accepted, with Paranthropus considered a subgenus of Australopithecus by some authors. Two questions arise from the classification of the newly discovered fossils: (i) Should each one of these specimens be placed in the family Hominidae? (ii) Are these specimens sufficiently distinct to justify the creation of four new genera? The answers depend, in turn, on the concepts of what is a hominid and how the genus category is defined. These specimens seem to possess a sufficient number of morphological traits to be placed in the Hominidae. However, the nature of the morphological evidence and the adaptation-rooted concept of what a genus is do not justify the establishment of four new genera. We propose a classification that includes four well defined genera: Praeanthropus, Ardipithecus, Australopithecus, and Homo, plus one tentative incertae sedis genus: Sahelanthropus. PMID:12794185

  3. A research program to assess the impact of the electromagnetic pulse on electric power systems

    NASA Astrophysics Data System (ADS)

    McConnell, B. W.; Barnes, P. R.

    A strong electromagnetic pulse (EMP) with an electric-field component on the order of tens of kilovolts per meter is produced by a nuclear detonation in or above the atmosphere. This paper presents an overview and a summary of the results to date of a program formulated to address the research and development of technologies and systems required to assess and reduce the impact of EMP on electric power systems. The technologies and systems being considered include simulation models, methods of assessment, definition of required experiments and data, development of protective hardware, and the creation or revision of operating and control procedures. Results to date include the development of relatively simple unclassified EMP environment models, the development of methods for extending EMP coupling models to the large transmission and distribution network associated with the electric power system, and the performance of a parametric study of HEMP induced surges using an appropriate EMP environment. An experiment to investigate the effect of corona on the coupling of EMP to conductors has been defined and has been performed in an EMP simulator. Experiments to determine the response of key components to simulated EMP surges and an investigation of the impact of steep-front, short-duration impulse on a selected number of the insulation systems used in electric power systems apparatus are being performed.

  4. Achieving Research Impact Through Co-creation in Community-Based Health Services: Literature Review and Case Study.

    PubMed

    Greenhalgh, Trisha; Jackson, Claire; Shaw, Sara; Janamian, Tina

    2016-06-01

    Co-creation-collaborative knowledge generation by academics working alongside other stakeholders-is an increasingly popular approach to aligning research and service development. It has potential for "moving beyond the ivory towers" to deliver significant societal impact via dynamic, locally adaptive community-academic partnerships. Principles of successful co-creation include a systems perspective, a creative approach to research focused on improving human experience, and careful attention to governance and process. If these principles are not followed, co-creation efforts may fail. Co-creation-collaborative knowledge generation by academics working alongside other stakeholders-reflects a "Mode 2" relationship (knowledge production rather than knowledge translation) between universities and society. Co-creation is widely believed to increase research impact. We undertook a narrative review of different models of co-creation relevant to community-based health services. We contrasted their diverse disciplinary roots and highlighted their common philosophical assumptions, principles of success, and explanations for failures. We applied these to an empirical case study of a community-based research-service partnership led by the Centre of Research Excellence in Quality and Safety in Integrated Primary-Secondary Care at the University of Queensland, Australia. Co-creation emerged independently in several fields, including business studies ("value co-creation"), design science ("experience-based co-design"), computer science ("technology co-design"), and community development ("participatory research"). These diverse models share some common features, which were also evident in the case study. Key success principles included (1) a systems perspective (assuming emergence, local adaptation, and nonlinearity); (2) the framing of research as a creative enterprise with human experience at its core; and (3) an emphasis on process (the framing of the program, the nature of relationships, and governance and facilitation arrangements, especially the style of leadership and how conflict is managed). In both the literature review and the case study, co-creation "failures" could often be tracked back to abandoning (or never adopting) these principles. All co-creation models made strong claims for significant and sustainable societal impacts as a result of the adaptive and developmental research process; these were illustrated in the case study. Co-creation models have high potential for societal impact but depend critically on key success principles. To capture the nonlinear chains of causation in the co-creation pathway, impact metrics must reflect the dynamic nature and complex interdependencies of health research systems and address processes as well as outcomes. © 2016 Milbank Memorial Fund.

  5. Global analysis of exon creation versus loss and the role of alternative splicing in 17 vertebrate genomes

    PubMed Central

    Alekseyenko, Alexander V.; Kim, Namshin; Lee, Christopher J.

    2007-01-01

    Association of alternative splicing (AS) with accelerated rates of exon evolution in some organisms has recently aroused widespread interest in its role in evolution of eukaryotic gene structure. Previous studies were limited to analysis of exon creation or lost events in mouse and/or human only. Our multigenome approach provides a way for (1) distinguishing creation and loss events on the large scale; (2) uncovering details of the evolutionary mechanisms involved; (3) estimating the corresponding rates over a wide range of evolutionary times and organisms; and (4) assessing the impact of AS on those evolutionary rates. We use previously unpublished independent analyses of alternative splicing in five species (human, mouse, dog, cow, and zebrafish) from the ASAP database combined with genomewide multiple alignment of 17 genomes to analyze exon creation and loss of both constitutively and alternatively spliced exons in mammals, fish, and birds. Our analysis provides a comprehensive database of exon creation and loss events over 360 million years of vertebrate evolution, including tens of thousands of alternative and constitutive exons. We find that exon inclusion level is inversely related to the rate of exon creation. In addition, we provide a detailed in-depth analysis of mechanisms of exon creation and loss, which suggests that a large fraction of nonrepetitive created exons are results of ab initio creation from purely intronic sequences. Our data indicate an important role for alternative splicing in creation of new exons and provide a useful novel database resource for future genome evolution research. PMID:17369312

  6. Knowledge Value Creation Characteristics of Virtual Teams: A Case Study in the Construction Sector

    NASA Astrophysics Data System (ADS)

    Vorakulpipat, Chalee; Rezgui, Yacine

    Any knowledge environment aimed at virtual teams should promote identification, access, capture and retrieval of relevant knowledge anytime / anywhere, while nurturing the social activities that underpin the knowledge sharing and creation process. In fact, socio-cultural issues play a critical role in the successful implementation of Knowledge Management (KM), and constitute a milestone towards value creation. The findings indicate that Knowledge Management Systems (KMS) promote value creation when they embed and nurture the social conditions that bind and bond team members together. Furthermore, technology assets, human networks, social capital, intellectual capital, and change management are identified as essential ingredients that have the potential to ensure effective knowledge value creation.

  7. Thermodynamics and emergent universe

    NASA Astrophysics Data System (ADS)

    Ghosh, Saumya; Gangopadhyay, Sunandan

    2017-05-01

    We show that in the isentropic scenario, the first-order thermodynamical particle creation model gives an emergent universe solution even when the chemical potential is nonzero. However, there exists no emergent universe scenario in the second-order non-equilibrium theory for the particle creation model. We then point out a correspondence between the particle creation model with barotropic equation of state and the equation of state giving rise to an emergent universe without particle creation in spatially flat FRW cosmology.

  8. Dating young geomorphic surfaces using age of colonizing Douglas fir in southwestern Washington and northwestern Oregon, USA

    USGS Publications Warehouse

    Pierson, T.C.

    2007-01-01

    Dating of dynamic, young (<500 years) geomorphic landforms, particularly volcanofluvial features, requires higher precision than is possible with radiocarbon dating. Minimum ages of recently created landforms have long been obtained from tree-ring ages of the oldest trees growing on new surfaces. But to estimate the year of landform creation requires that two time corrections be added to tree ages obtained from increment cores: (1) the time interval between stabilization of the new landform surface and germination of the sampled trees (germination lag time or GLT); and (2) the interval between seedling germination and growth to sampling height, if the trees are not cored at ground level. The sum of these two time intervals is the colonization time gap (CTG). Such time corrections have been needed for more precise dating of terraces and floodplains in lowland river valleys in the Cascade Range, where significant eruption-induced lateral shifting and vertical aggradation of channels can occur over years to decades, and where timing of such geomorphic changes can be critical to emergency planning. Earliest colonizing Douglas fir (Pseudotsuga menziesii) were sampled for tree-ring dating at eight sites on lowland (<750 m a.s.l.), recently formed surfaces of known age near three Cascade volcanoes - Mount Rainier, Mount St. Helens and Mount Hood - in southwestern Washington and northwestern Oregon. Increment cores or stem sections were taken at breast height and, where possible, at ground level from the largest, oldest-looking trees at each study site. At least ten trees were sampled at each site unless the total of early colonizers was less. Results indicate that a correction of four years should be used for GLT and 10 years for CTG if the single largest (and presumed oldest) Douglas fir growing on a surface of unknown age is sampled. This approach would have a potential error of up to 20 years. Error can be reduced by sampling the five largest Douglas fir instead of the single largest. A GLT correction of 5 years should be added to the mean ring-count age of the five largest trees growing on the surface being dated, if the trees are cored at ground level. This correction would have an approximate error of ??5 years. If the trees are cored at about 1.4 m above the round surface (breast height), a CTG correction of 11 years should be added to the mean age of the five sampled trees (with an error of about ??7 years).

  9. 9 CFR 416.5 - Employee hygiene.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... product and the creation of insanitary conditions. (b) Clothing. Aprons, frocks, and other outer clothing... as necessary to prevent adulteration of product and the creation of insanitary conditions. (c... from any operations which could result in product adulteration and the creation of insanitary...

  10. 9 CFR 416.5 - Employee hygiene.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... product and the creation of insanitary conditions. (b) Clothing. Aprons, frocks, and other outer clothing... as necessary to prevent adulteration of product and the creation of insanitary conditions. (c... from any operations which could result in product adulteration and the creation of insanitary...

  11. 9 CFR 416.5 - Employee hygiene.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... product and the creation of insanitary conditions. (b) Clothing. Aprons, frocks, and other outer clothing... as necessary to prevent adulteration of product and the creation of insanitary conditions. (c... from any operations which could result in product adulteration and the creation of insanitary...

  12. 9 CFR 416.5 - Employee hygiene.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... product and the creation of insanitary conditions. (b) Clothing. Aprons, frocks, and other outer clothing... as necessary to prevent adulteration of product and the creation of insanitary conditions. (c... from any operations which could result in product adulteration and the creation of insanitary...

  13. Vascular Access Creation before Hemodialysis Initiation and Use: A Population-Based Cohort Study

    PubMed Central

    Al-Jaishi, Ahmed A.; Lok, Charmaine E.; Garg, Amit X.; Zhang, Joyce C.

    2015-01-01

    Background and objectives In Canada, approximately 17% of patients use an arteriovenous access (fistula or arteriovenous graft) at commencement of hemodialysis, despite guideline recommendations promoting its timely creation and use. It is unclear if this low pattern of use is attributable to the lack of surgical creation or a high nonuse rate. Design, setting, participants, & measurements Using large health care databases in Ontario, Canada, a population-based cohort of adult patients (≥18 years old) who initiated hemodialysis as their first form of RRT between 2001 and 2010 was studied. The aims were to (1) estimate the proportion of patients who had an arteriovenous access created before starting hemodialysis and the proportion who successfully used it at hemodialysis start, (2) test for secular trends in arteriovenous access creation, and (3) estimate the effect of late nephrology referral and patient characteristics on arteriovenous access creation. Results There were 17,183 patients on incident hemodialysis. The mean age was 65.8 years, 60% were men, and 40% were referred late to a nephrologist; 27% of patients (4556 of 17,183) had one or more arteriovenous accesses created, and the median time between arteriovenous access creation and hemodialysis start was 184 days. When late referrals were excluded, 39% of patients (4007 of 10,291) had one or more arteriovenous accesses created, and 27% of patients (2724 of 10,291) used the arteriovenous access. Since 2001, there has been a decline in arteriovenous access creation before hemodialysis initiation. Women, higher numbers of comorbidities, and rural residence were consistently associated with lower rates of arteriovenous access creation. These results persisted even after removing patients with <6 months nephrology care or who had AKI 6 months before starting hemodialysis. Conclusions In Canada, arteriovenous access creation before hemodialysis initiation is low, even among patients followed by a nephrologist. Better understanding of the barriers and influencers of arteriovenous access creation is needed to inform both clinical care and guidelines. PMID:25568219

  14. Vascular access creation before hemodialysis initiation and use: a population-based cohort study.

    PubMed

    Al-Jaishi, Ahmed A; Lok, Charmaine E; Garg, Amit X; Zhang, Joyce C; Moist, Louise M

    2015-03-06

    In Canada, approximately 17% of patients use an arteriovenous access (fistula or arteriovenous graft) at commencement of hemodialysis, despite guideline recommendations promoting its timely creation and use. It is unclear if this low pattern of use is attributable to the lack of surgical creation or a high nonuse rate. Using large health care databases in Ontario, Canada, a population-based cohort of adult patients (≥18 years old) who initiated hemodialysis as their first form of RRT between 2001 and 2010 was studied. The aims were to (1) estimate the proportion of patients who had an arteriovenous access created before starting hemodialysis and the proportion who successfully used it at hemodialysis start, (2) test for secular trends in arteriovenous access creation, and (3) estimate the effect of late nephrology referral and patient characteristics on arteriovenous access creation. There were 17,183 patients on incident hemodialysis. The mean age was 65.8 years, 60% were men, and 40% were referred late to a nephrologist; 27% of patients (4556 of 17,183) had one or more arteriovenous accesses created, and the median time between arteriovenous access creation and hemodialysis start was 184 days. When late referrals were excluded, 39% of patients (4007 of 10,291) had one or more arteriovenous accesses created, and 27% of patients (2724 of 10,291) used the arteriovenous access. Since 2001, there has been a decline in arteriovenous access creation before hemodialysis initiation. Women, higher numbers of comorbidities, and rural residence were consistently associated with lower rates of arteriovenous access creation. These results persisted even after removing patients with <6 months nephrology care or who had AKI 6 months before starting hemodialysis. In Canada, arteriovenous access creation before hemodialysis initiation is low, even among patients followed by a nephrologist. Better understanding of the barriers and influencers of arteriovenous access creation is needed to inform both clinical care and guidelines. Copyright © 2015 by the American Society of Nephrology.

  15. Why I teach the controversy: using creationism to teach critical thinking

    PubMed Central

    Honey, P. Lynne

    2015-01-01

    Creationism and intelligent design are terms used to describe supernatural explanations for the origin of life, and the diversity of species on this planet. Many scientists have argued that the science classroom is no place for discussion of creationism. When I began teaching I did not teach creationism, as I focused instead on my areas of expertise. Over time it became clear that students had questions about creationism, and did not understand the difference between a scientific approach to knowledge and non-scientific approaches. This led me to wonder whether ignoring supernatural views allowed them to remain as viable “alternatives” to scientific hypotheses, in the minds of students. Also, a psychology class is an ideal place to discuss not only the scientific method but also the cognitive errors associated with non-science views. I began to explain creationism in my classes, and to model the scientific thought process that leads to a rejection of creationism. My approach is consistent with research that demonstrates that teaching content alone is insufficient for students to develop critical thinking and my admittedly anecdotal experience leads me to conclude that “teaching the controversy” has benefits for science students. PMID:26136700

  16. Social Network Modeling and Simulation of Integrated Resilient Command and Control (C2) in Contested Cyber Environments

    DTIC Science & Technology

    2011-12-09

    traced to non-state actors it provided the impetus to the creation of Joint Task Force Computer Network Defense (JTF-CND). Since the creation of JTF...telecommunications and IT systems. One of those many efforts by the USAF has been the creation of the 24th Air Force (24th AF), also known as US Air Force...Support For Organizational Structures, Policies, Technologies and People to Improve Resilience Prior to creation of USCYBERCOM, responsibility for

  17. Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia.

    PubMed

    Nemoto, Michiko; Hattori, Hiroyoshi; Maeda, Naoko; Akita, Nobuhiro; Muramatsu, Hideki; Moritani, Suzuko; Kawasaki, Tomonori; Maejima, Masami; Ode, Hirotaka; Hachiya, Atsuko; Sugiura, Wataru; Yokomaku, Yoshiyuki; Horibe, Keizo; Iwatani, Yasumasa

    2018-05-03

    Complete tyrosine kinase 2 (TYK2) deficiency has been previously described in patients with primary immunodeficiency diseases. The patients were infected with various pathogens, including mycobacteria and/or viruses, and one of the patients developed hyper-IgE syndrome. A detailed immunological investigation of these patients revealed impaired responses to type I IFN, IL-10, IL-12 and IL-23, which are associated with increased susceptibility to mycobacterial and/or viral infections. Herein, we report a recessive partial TYK2 deficiency in two siblings who presented with T-cell lymphopenia characterized by low naïve CD4 + T-cell counts and who developed Epstein-Barr virus (EBV)-associated B-cell lymphoma. Targeted exome-sequencing of the siblings' genomes demonstrated that both patients carried novel compound heterozygous mutations (c.209_212delGCTT/c.691C > T, p.Cys70Serfs*21/p.Arg231Trp) in the TYK2. The TYK2 protein levels were reduced by 35% in the T cells of the patient. Unlike the response under complete TYK2 deficiency, the patient's T cells responded normally to type I IFN, IL-6, IL-10 and IL-12, whereas the cells displayed an impaired response to IL-23. Furthermore, the level of STAT1 was low in the cells of the patient. These studies reveal a new clinical entity of a primary immunodeficiency with T-cell lymphopenia that is associated with compound heterozygous TYK2 mutations in the patients.

  18. Utility of whole exome sequencing in the diagnosis of Usher syndrome: Report of novel compound heterozygous MYO7A mutations.

    PubMed

    Ramzan, Khushnooda; Al-Owain, Mohammed; Huma, Rozeena; Al-Hazzaa, Selwa A F; Al-Ageel, Sarah; Imtiaz, Faiqa; Al-Sayed, Moeenaldeen

    2018-05-01

    Next generation sequencing (NGS), such as targeted panel sequencing, whole-exome sequencing and whole-genome sequencing has led to an exponential increase of elucidated genetic causes in both rare diseases, and common but heterogeneous disorders. NGS is applied in both research and clinical settings, and the clinical exome sequencing (CES), which provides not only the sequence variation data but also clinical interpretation, aids in reaching a final conclusion with regards to a genetic diagnosis. Usher syndrome is a group of disorders, characterized by bilateral sensorineural hearing loss, with or without vestibular dysfunction and retinitis pigmentosa. The index patient, a 2-year-old child was initially diagnosed with nonsyndromic hearing impairment. Homozygosity mapping followed by CES was utilized as a diagnostic tool to identify the genetic basis of his hearing loss. A paternally inherited novel insertion, c.198_199insA (p.Val67Serfs*73) and a maternally inherited novel deletion, c.1219_1226del (p.Phe407Aspfs*33) in gene MYO7A were found in compound heterozygous state in the index patient. The result expands the mutational spectrum of MYO7A. In addition it helped in early diagnosis of the syndrome, for planning and adjustments for the patient, and as well as for future family planning. This study highlights the clinical effectiveness of CES for Usher syndrome diagnosis in a child presented with congenital hearing loss. Copyright © 2018. Published by Elsevier B.V.

  19. Usher syndrome in Denmark: mutation spectrum and some clinical observations.

    PubMed

    Dad, Shzeena; Rendtorff, Nanna Dahl; Tranebjærg, Lisbeth; Grønskov, Karen; Karstensen, Helena Gásdal; Brox, Vigdis; Nilssen, Øivind; Roux, Anne-Françoise; Rosenberg, Thomas; Jensen, Hanne; Møller, Lisbeth Birk

    2016-09-01

    Usher syndrome (USH) is a genetically heterogeneous deafness-blindness syndrome, divided into three clinical subtypes: USH1, USH2 and USH3. Mutations in 21 out of 26 investigated Danish unrelated individuals with USH were identified, using a combination of molecular diagnostic methods. Before Next Generation Sequencing (NGS) became available mutations in nine individuals (1 USH1, 7 USH2, 1 USH3) were identified by Sanger sequencing of USH1C , USH2A or CLRN1 or by Arrayed Primer EXtension (APEX) method. Mutations in 12 individuals (7 USH1, 5 USH2) were found by targeted NGS of ten known USH genes. Five novel pathogenic variants were identified. We combined our data with previously published, and obtained an overview of the USH mutation spectrum in Denmark, including 100 unrelated individuals; 32 with USH1, 67 with USH2, and 1 with USH3. Macular edema was observed in 44 of 117 individuals. Olfactory function was tested in 12 individuals and found to be within normal range in all. Mutations that lead to USH1 were predominantly identified in MYO7A (75%), whereas all mutations in USH2 cases were identified in USH2A . The MYO7A mutation c.93C>A, p.(Cys31*) accounted for 33% of all USH1 mutations and the USH2A c.2299delG, p.(Glu767Serfs*21) variant accounted for 45% of all USH2 mutations in the Danish cohort.

  20. Comparison between photon annihilation-then-creation and photon creation-then-annihilation thermal states: Non-classical and non-Gaussian properties

    NASA Astrophysics Data System (ADS)

    Xu, Xue-Xiang; Yuan, Hong-Chun; Wang, Yan

    2014-07-01

    We investigate the nonclassical properties of arbitrary number photon annihilation-then-creation operation (AC) and creation-then-annihilation operation (CA) to the thermal state (TS), whose normalization factors are related to the polylogarithm function. Then we compare their quantum characters, such as photon number distribution, average photon number, Mandel Q-parameter, purity and the Wigner function. Because of the noncommutativity between the annihilation operator and the creation operator, the ACTS and the CATS have different nonclassical properties. It is found that nonclassical properties are exhibited more strongly after AC than after CA. In addition we also examine their non-Gaussianity. The result shows that the ACTS can present a slightly bigger non-Gaussianity than the CATS.

  1. 42 CFR 401.120 - Creation of records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Creation of records. 401.120 Section 401.120 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS GENERAL ADMINISTRATIVE REQUIREMENTS Confidentiality and Disclosure § 401.120 Creation of records...

  2. 14 CFR 1201.100 - Creation and authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Creation and authority. 1201.100 Section 1201.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.100 Creation and authority. The National Aeronautics and...

  3. 14 CFR 1201.100 - Creation and authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Creation and authority. 1201.100 Section 1201.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.100 Creation and authority. The National Aeronautics and...

  4. 14 CFR 1201.100 - Creation and authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Creation and authority. 1201.100 Section 1201.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.100 Creation and authority. The National Aeronautics and...

  5. 42 CFR 401.120 - Creation of records.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Creation of records. 401.120 Section 401.120 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS GENERAL ADMINISTRATIVE REQUIREMENTS Confidentiality and Disclosure § 401.120 Creation of records...

  6. 42 CFR 401.120 - Creation of records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Creation of records. 401.120 Section 401.120 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS GENERAL ADMINISTRATIVE REQUIREMENTS Confidentiality and Disclosure § 401.120 Creation of records...

  7. 42 CFR 401.120 - Creation of records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Creation of records. 401.120 Section 401.120 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS GENERAL ADMINISTRATIVE REQUIREMENTS Confidentiality and Disclosure § 401.120 Creation of records...

  8. 42 CFR 401.120 - Creation of records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Creation of records. 401.120 Section 401.120 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS GENERAL ADMINISTRATIVE REQUIREMENTS Confidentiality and Disclosure § 401.120 Creation of records...

  9. 14 CFR 1201.100 - Creation and authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Creation and authority. 1201.100 Section 1201.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.100 Creation and authority. The National Aeronautics and...

  10. Toward a Broader Perspective in the Evolutionism-Creationism Debate.

    ERIC Educational Resources Information Center

    Strahler, Arthur N.

    1983-01-01

    Examines creationism/evolution debate in context of philosophy using ontological models in which reality is assigned to one or both natural or transnatural (supernatural) realms. The six models (theistic-teleological dualism; deistic-mechanistic dualism; fundamentalist creationism; atheistic monism; theistic monism; mechanistic monism) deal with…

  11. Creationism, Censorship, and Academic Freedom.

    ERIC Educational Resources Information Center

    Sturm, Susan P.

    1982-01-01

    Argues that the fight against creationism in public schools is essential to the preservation of First Amendment rights guaranteed by the U.S. Constitution. Discusses how creationists, to avoid religious issues, are presenting the "creation-science" (pseudoscience) issue in terms of academic freedom and censorship. (Author/JN)

  12. Using creation science to demonstrate evolution: application of a creationist method for visualizing gaps in the fossil record to a phylogenetic study of coelurosaurian dinosaurs.

    PubMed

    Senter, P

    2010-08-01

    It is important to demonstrate evolutionary principles in such a way that they cannot be countered by creation science. One such way is to use creation science itself to demonstrate evolutionary principles. Some creation scientists use classic multidimensional scaling (CMDS) to quantify and visualize morphological gaps or continuity between taxa, accepting gaps as evidence of independent creation and accepting continuity as evidence of genetic relatedness. Here, I apply CMDS to a phylogenetic analysis of coelurosaurian dinosaurs and show that it reveals morphological continuity between Archaeopteryx, other early birds, and a wide range of nonavian coelurosaurs. Creation scientists who use CMDS must therefore accept that these animals are genetically related. Other uses of CMDS for evolutionary biologists include the identification of taxa with much missing evolutionary history and the tracing of the progressive filling of morphological gaps in the fossil record through successive years of discovery.

  13. Network Analysis of an Emergent Massively Collaborative Creation on Video Sharing Website

    NASA Astrophysics Data System (ADS)

    Hamasaki, Masahiro; Takeda, Hideaki; Nishimura, Takuichi

    The Web technology enables numerous people to collaborate in creation. We designate it as massively collaborative creation via the Web. As an example of massively collaborative creation, we particularly examine video development on Nico Nico Douga, which is a video sharing website that is popular in Japan. We specifically examine videos on Hatsune Miku, a version of a singing synthesizer application software that has inspired not only song creation but also songwriting, illustration, and video editing. As described herein, creators of interact to create new contents through their social network. In this paper, we analyzed the process of developing thousands of videos based on creators' social networks and investigate relationships among creation activity and social networks. The social network reveals interesting features. Creators generate large and sparse social networks including some centralized communities, and such centralized community's members shared special tags. Different categories of creators have different roles in evolving the network, e.g., songwriters gather more links than other categories, implying that they are triggers to network evolution.

  14. Is the continuous matter creation cosmology an alternative to ΛCDM?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fabris, J.C.; Pacheco, J.A. de Freitas; Piattella, O.F., E-mail: fabris@pq.cnpq.br, E-mail: pacheco@oca.eu, E-mail: oliver.piattella@pq.cnpq.br

    2014-06-01

    The matter creation cosmology is revisited, including the evolution of baryons and dark matter particles. The creation process affects only dark matter and not baryons. The dynamics of the ΛCDM model can be reproduced only if two conditions are satisfied: 1) the entropy density production rate and the particle density variation rate are equal and 2) the (negative) pressure associated to the creation process is constant. However, the matter creation model predicts a present dark matter-to-baryon ratio much larger than that observed in massive X-ray clusters of galaxies, representing a potential difficulty for the model. In the linear regime, amore » fully relativistic treatment indicates that baryons are not affected by the creation process but this is not the case for dark matter. Both components evolve together at early phases but lately the dark matter density contrast decreases since the background tends to a constant value. This behaviour produces a negative growth factor, in disagreement with observations, being a further problem for this cosmology.« less

  15. Likelihood of Starting Dialysis after Incident Fistula Creation

    PubMed Central

    Quinn, Robert R.; Garg, Amit X.; Kim, S. Joseph; Wald, Ron; Paterson, J. Michael

    2012-01-01

    Summary Background and objectives Guidelines promote early fistula creation to avoid central venous catheter use. This practice may lead to fistula creations in patients who never receive dialysis. The objective of this study was to estimate the risk of fistula nonuse with long-term follow-up. Design, setting, participants, & measurements Administrative health data identified 1929 predialysis adults who had their first fistula creation between April of 2002 and March of 2006. Patients were followed for a minimum of 2 years or until they began dialysis, received a kidney transplant, or died. Results The median follow-up times in patients who started dialysis, died without receiving dialysis, and remained in predialysis were 6.1, 11.5, and 38.7 months, respectively. Eighty-one percent of patients initiated dialysis; 9% of patients died without receiving dialysis, and 10% of patients remained predialysis. Forty percent of patients had their first fistula creation 3–12 months before initiating dialysis (the recommended window). Thirty percent were created within 90 days of starting dialysis; 30% were created more than 1 year before starting dialysis, and 10% were created more than 2 years before starting dialysis. Older patients, females, and patients with less comorbidity were not as likely to initiate dialysis after incident fistula creation. Conclusions Most patients who underwent fistula creation before starting dialysis eventually received dialysis with extended follow-up, but the risk was significantly modified by age, sex, and comorbidity. Many patients had fistula creations earlier or later than recommended. PMID:22344512

  16. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a) General...

  17. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a) General...

  18. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a) General...

  19. 8 CFR 204.6 - Petitions for employment creation aliens.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Petitions for employment creation aliens. 204.6 Section 204.6 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.6 Petitions for employment creation aliens. (a) General...

  20. Crowdsourcing Content Creation in the Classroom

    ERIC Educational Resources Information Center

    Hills, Thomas T.

    2015-01-01

    The recent growth in crowdsourcing technologies offers a new way of envisioning student involvement in the classroom. This article describes a participatory action research approach to combining crowdsourced content creation with the student as producer model, whereby students' interests are used to drive the identification and creation of…

  1. 41 CFR 105-53.110 - Creation and authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Creation and authority. 105-53.110 Section 105-53.110 Public Contracts and Property Management Federal Property Management... General § 105-53.110 Creation and authority. The General Services Administration was established by...

  2. 41 CFR 105-53.110 - Creation and authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Creation and authority. 105-53.110 Section 105-53.110 Public Contracts and Property Management Federal Property Management... General § 105-53.110 Creation and authority. The General Services Administration was established by...

  3. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  4. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  5. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  6. 41 CFR 105-53.110 - Creation and authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Creation and authority. 105-53.110 Section 105-53.110 Public Contracts and Property Management Federal Property Management... General § 105-53.110 Creation and authority. The General Services Administration was established by...

  7. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  8. 31 CFR 354.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Creation of Participant's Security Entitlement; security interests. 354.4 Section 354.4 Money and Finance: Treasury Regulations Relating to Money... Creation of Participant's Security Entitlement; security interests. (a) A Participant's Security...

  9. History Forum Addresses Creation/Evolution Controversy.

    ERIC Educational Resources Information Center

    Schweinsberg, John

    1997-01-01

    A series of programs entitled Creationism and Evolution: The History of a Controversy was presented at the University of Alabama in Huntsville. The controversy was addressed from an historical and sociological, rather than a scientific perspective. Speakers addressed the evolution of scientific creationism, ancient texts versus sedimentary rocks…

  10. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the U.S...

  11. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of 1974...

  12. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of 1974...

  13. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the U.S...

  14. Managing Research Output for Knowledge Creation in South-South Nigerian Universities

    ERIC Educational Resources Information Center

    Akuegwu, B. A.; Edet, A. O.; Uchendu, C. C.

    2012-01-01

    This ex-post facto designed study investigated the extent of Deans and Heads of Departments' effectiveness in managing research output for knowledge creation in South-South Nigerian universities. One research question and one hypothesis were drawn along the four dimensions of knowledge creation namely: socialization, combination, externalization…

  15. Mangrove soil and vegetation change after tidal wetland creation: a 20-year chronosequence in Tampa Bay, FL

    EPA Science Inventory

    Mangrove restoration and creation efforts are increasingly proposed as mechanisms to compensate for mangrove loss (which has been high in recent decades: ~30-50% global loss). However, ecosystem development and functionality following mangrove restoration and creation is poorly u...

  16. The Creation-Evolution Debate as a Model of Issue Polarization.

    ERIC Educational Resources Information Center

    Wielert, Jan S.

    1983-01-01

    The Almond model of public opinion can be modified to produce an issue-polarization model of the creation-evolution debate. Suggests that the nonattentive public may hold more potential for expanding the ranks of pro-evolution attentives than for expanding the ranks of those favoring creationism. (JN)

  17. FAST TRACK COMMUNICATION: Open string pair creation from worldsheet instantons

    NASA Astrophysics Data System (ADS)

    Schubert, Christian; Torrielli, Alessandro

    2010-10-01

    Worldline instantons provide a particularly elegant way to derive Schwinger's well-known formula for the pair creation rate due to a constant electric field in quantum electrodynamics. In this communication, we show how to extend this method to the corresponding problem of open string pair creation.

  18. 75 FR 67084 - Notice of Availability of the Draft Programmatic Environmental Impact Statement for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-01

    ... Draft Programmatic Environmental Impact Statement for the Mechanical Creation and Maintenance of... the Mechanical Creation and Maintenance of Emergent Sandbar Habitat on the Riverine Segments of the... Environmental Impact Statement for the Mechanical Creation and Maintenance of Emergent Sandbar Habitat in the...

  19. Knowledge Creation in Construction Organisations: A Case Approach

    ERIC Educational Resources Information Center

    Eliufoo, Harriet

    2008-01-01

    Purpose: The purpose of this paper is to investigate and characterise the knowledge creation process in construction organisations and explore to what extent organisations facilitate the process. Design/methodology/approach: A case study approach is adopted using four construction organisations; a knowledge creation model is also used as the…

  20. Distinguishing Knowledge-Sharing, Knowledge-Construction, and Knowledge-Creation Discourses

    ERIC Educational Resources Information Center

    van Aalst, Jan

    2009-01-01

    The study reported here sought to obtain the clear articulation of asynchronous computer-mediated discourse needed for Carl Bereiter and Marlene Scardamalia's knowledge-creation model. Distinctions were set up between three modes of discourse: knowledge sharing, knowledge construction, and knowledge creation. These were applied to the asynchronous…

  1. 12 CFR 611.1040 - Creation of new associations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Creation of new associations. 611.1040 Section 611.1040 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Bank Mergers, Consolidations and Charter Amendments § 611.1040 Creation of new associations. Any application for the issuance...

  2. 24 CFR 300.5 - Creation and status.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Creation and status. 300.5 Section 300.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Creation and status. The Association is a Government corporation in the Department of Housing and Urban...

  3. 12 CFR 987.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Creation of Participant's Security Entitlement; security interests. 987.4 Section 987.4 Banks and Banking FEDERAL HOUSING FINANCE BOARD OFFICE OF FINANCE BOOK-ENTRY PROCEDURE FOR CONSOLIDATED OBLIGATIONS § 987.4 Creation of Participant's Security...

  4. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of 1974...

  5. 17 CFR 45.5 - Unique swap identifiers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... transmit a unique swap identifier as provided in paragraphs (a)(1) and (2) of this section. (1) Creation... prior to the reporting of required swap creation data. The unique swap identifier shall consist of a... execution facility or designated contract market with respect to unique swap identifier creation; and (ii...

  6. 14 CFR 1206.203 - Creation of records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Creation of records. 1206.203 Section 1206.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.203 Creation of records. Records will not be...

  7. 18 CFR 1314.5 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Creation of Participant's Security Entitlement; security interests. 1314.5 Section 1314.5 Conservation of Power and Water... FEDERAL RESERVE BANKS § 1314.5 Creation of Participant's Security Entitlement; security interests. (a) A...

  8. 24 CFR 81.93 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Creation of Participant's Security Entitlement; security interests. 81.93 Section 81.93 Housing and Urban Development Office of the Secretary... Procedures § 81.93 Creation of Participant's Security Entitlement; security interests. (a) A Participant's...

  9. Research on Education in the Knowledge Creation Paradigm

    ERIC Educational Resources Information Center

    Tan, Seng Chee; Ow, John; Chai, ChingSing; Teo, Chew-Lee; Yeo, Jennifer

    2014-01-01

    To better prepare learners for the "knowledge society," educators in Singapore have embarked on a journey in experimenting with knowledge creation pedagogy in classrooms. The Knowledge Creation and Innovative Design Centre was set up to further coordinate this effort. In this article, the authors give an account of the historical…

  10. 12 CFR 611.1040 - Creation of new associations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Creation of new associations. 611.1040 Section 611.1040 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Bank Mergers, Consolidations and Charter Amendments § 611.1040 Creation of new associations. Any application for the issuance...

  11. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the U.S...

  12. 12 CFR 1270.14 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Creation of Participant's Security Entitlement; security interests. 1270.14 Section 1270.14 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS LIABILITIES Book-Entry Procedure for Consolidated Obligations § 1270.14 Creation of...

  13. 18 CFR 1314.5 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Creation of Participant's Security Entitlement; security interests. 1314.5 Section 1314.5 Conservation of Power and Water... FEDERAL RESERVE BANKS § 1314.5 Creation of Participant's Security Entitlement; security interests. (a) A...

  14. 12 CFR 1249.13 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Creation of Participant's Security Entitlement; security interests. 1249.13 Section 1249.13 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES BOOK-ENTRY PROCEDURES § 1249.13 Creation of Participant's Security Entitlement; security interests. (a...

  15. 14 CFR § 1201.100 - Creation and authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Creation and authority. § 1201.100 Section § 1201.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1201.100 Creation and authority. The National Aeronautics...

  16. 12 CFR 611.1040 - Creation of new associations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Creation of new associations. 611.1040 Section 611.1040 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Bank Mergers, Consolidations and Charter Amendments § 611.1040 Creation of new associations. Any application for the issuance...

  17. 14 CFR 1206.203 - Creation of records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Creation of records. 1206.203 Section 1206.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.203 Creation of records. Records will not be...

  18. 12 CFR 1511.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Creation of Participant's Security Entitlement; security interests. 1511.4 Section 1511.4 Banks and Banking DEPARTMENT OF THE TREASURY RESOLUTION FUNDING CORPORATION BOOK-ENTRY PROCEDURE § 1511.4 Creation of Participant's Security Entitlement; security interests...

  19. 24 CFR 300.5 - Creation and status.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Creation and status. 300.5 Section 300.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Creation and status. The Association is a Government corporation in the Department of Housing and Urban...

  20. 12 CFR 615.5454 - Creation of participant's security entitlement; security interests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Creation of participant's security entitlement; security interests. 615.5454 Section 615.5454 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT... Procedures for Farm Credit Securities § 615.5454 Creation of participant's security entitlement; security...

  1. 24 CFR 350.5 - Creation of Participant's Security Entitlement; Security Interests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Creation of Participant's Security Entitlement; Security Interests. 350.5 Section 350.5 Housing and Urban Development Regulations Relating to... AND URBAN DEVELOPMENT BOOK-ENTRY PROCEDURES § 350.5 Creation of Participant's Security Entitlement...

  2. 24 CFR 300.5 - Creation and status.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Creation and status. 300.5 Section 300.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Creation and status. The Association is a Government corporation in the Department of Housing and Urban...

  3. 18 CFR 1314.5 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Creation of Participant's Security Entitlement; security interests. 1314.5 Section 1314.5 Conservation of Power and Water... FEDERAL RESERVE BANKS § 1314.5 Creation of Participant's Security Entitlement; security interests. (a) A...

  4. 17 CFR 201.1100 - Creation of Fair Fund.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Creation of Fair Fund. 201.1100 Section 201.1100 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Fair Fund and Disgorgement Plans § 201.1100 Creation of Fair Fund. In any agency process initiated...

  5. 24 CFR 81.93 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Creation of Participant's Security Entitlement; security interests. 81.93 Section 81.93 Housing and Urban Development Office of the Secretary... Procedures § 81.93 Creation of Participant's Security Entitlement; security interests. (a) A Participant's...

  6. 17 CFR 201.1100 - Creation of Fair Fund.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Creation of Fair Fund. 201.1100 Section 201.1100 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Fair Fund and Disgorgement Plans § 201.1100 Creation of Fair Fund. In any agency process initiated...

  7. 18 CFR 1314.5 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Creation of Participant's Security Entitlement; security interests. 1314.5 Section 1314.5 Conservation of Power and Water... FEDERAL RESERVE BANKS § 1314.5 Creation of Participant's Security Entitlement; security interests. (a) A...

  8. 24 CFR 300.5 - Creation and status.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Creation and status. 300.5 Section 300.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Creation and status. The Association is a Government corporation in the Department of Housing and Urban...

  9. 12 CFR 1249.13 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Creation of Participant's Security Entitlement; security interests. 1249.13 Section 1249.13 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES BOOK-ENTRY PROCEDURES § 1249.13 Creation of Participant's Security Entitlement; security interests. (a...

  10. 17 CFR 201.1100 - Creation of Fair Fund.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Creation of Fair Fund. 201.1100 Section 201.1100 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Fair Fund and Disgorgement Plans § 201.1100 Creation of Fair Fund. In any agency process initiated...

  11. 32 CFR 10.6 - Non-creation of right.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Non-creation of right. 10.6 Section 10.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS MILITARY COMMISSION INSTRUCTIONS § 10.6 Non-creation of right. Neither this part nor any Military Commission...

  12. 49 CFR 1150.34 - Caption summary-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Caption summary-transactions that involve creation of Class III carriers. 1150.34 Section 1150.34 Transportation Other Regulations Relating to....34 Caption summary—transactions that involve creation of Class III carriers. The caption summary must...

  13. 12 CFR 611.1040 - Creation of new associations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Creation of new associations. 611.1040 Section 611.1040 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Bank Mergers, Consolidations and Charter Amendments § 611.1040 Creation of new associations. Any application for the issuance...

  14. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of 1974...

  15. 24 CFR 81.93 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Creation of Participant's Security Entitlement; security interests. 81.93 Section 81.93 Housing and Urban Development Office of the Secretary... Procedures § 81.93 Creation of Participant's Security Entitlement; security interests. (a) A Participant's...

  16. 18 CFR 1314.5 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Creation of Participant's Security Entitlement; security interests. 1314.5 Section 1314.5 Conservation of Power and Water... FEDERAL RESERVE BANKS § 1314.5 Creation of Participant's Security Entitlement; security interests. (a) A...

  17. 14 CFR 1206.203 - Creation of records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Creation of records. 1206.203 Section 1206.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.203 Creation of records. Records will not be...

  18. 24 CFR 350.5 - Creation of Participant's Security Entitlement; Security Interests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Creation of Participant's Security Entitlement; Security Interests. 350.5 Section 350.5 Housing and Urban Development Regulations Relating to... AND URBAN DEVELOPMENT BOOK-ENTRY PROCEDURES § 350.5 Creation of Participant's Security Entitlement...

  19. 24 CFR 300.5 - Creation and status.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Creation and status. 300.5 Section 300.5 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... Creation and status. The Association is a Government corporation in the Department of Housing and Urban...

  20. 12 CFR 1270.14 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Creation of Participant's Security Entitlement; security interests. 1270.14 Section 1270.14 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS LIABILITIES Book-Entry Procedure for Consolidated Obligations § 1270.14 Creation of...

  1. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the U.S...

  2. 32 CFR 10.6 - Non-creation of right.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Non-creation of right. 10.6 Section 10.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS MILITARY COMMISSION INSTRUCTIONS § 10.6 Non-creation of right. Neither this part nor any Military Commission...

  3. 14 CFR 1206.203 - Creation of records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Creation of records. 1206.203 Section 1206.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.203 Creation of records. Records will not be...

  4. 49 CFR 1150.34 - Caption summary-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Caption summary-transactions that involve creation of Class III carriers. 1150.34 Section 1150.34 Transportation Other Regulations Relating to....34 Caption summary—transactions that involve creation of Class III carriers. The caption summary must...

  5. 17 CFR 45.5 - Unique swap identifiers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... transmit a unique swap identifier as provided in paragraphs (a)(1) and (2) of this section. (1) Creation... prior to the reporting of required swap creation data. The unique swap identifier shall consist of a... execution facility or designated contract market with respect to unique swap identifier creation; and (ii...

  6. 40 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Creation and authority. 1.1 Section 1.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. Reorganization Plan 3 of 1970, established the U.S...

  7. 49 CFR 1150.34 - Caption summary-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Caption summary-transactions that involve creation of Class III carriers. 1150.34 Section 1150.34 Transportation Other Regulations Relating to....34 Caption summary—transactions that involve creation of Class III carriers. The caption summary must...

  8. 12 CFR 615.5454 - Creation of participant's security entitlement; security interests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Creation of participant's security entitlement; security interests. 615.5454 Section 615.5454 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT... Procedures for Farm Credit Securities § 615.5454 Creation of participant's security entitlement; security...

  9. 12 CFR 1249.13 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Creation of Participant's Security Entitlement; security interests. 1249.13 Section 1249.13 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES BOOK-ENTRY PROCEDURES § 1249.13 Creation of Participant's Security Entitlement; security interests. (a...

  10. 17 CFR 45.5 - Unique swap identifiers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... transmit a unique swap identifier as provided in paragraphs (a)(1) and (2) of this section. (1) Creation... prior to the reporting of required swap creation data. The unique swap identifier shall consist of a... execution facility or designated contract market with respect to unique swap identifier creation; and (ii...

  11. 24 CFR 350.5 - Creation of Participant's Security Entitlement; Security Interests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Creation of Participant's Security Entitlement; Security Interests. 350.5 Section 350.5 Housing and Urban Development Regulations Relating to... AND URBAN DEVELOPMENT BOOK-ENTRY PROCEDURES § 350.5 Creation of Participant's Security Entitlement...

  12. 24 CFR 81.93 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Creation of Participant's Security Entitlement; security interests. 81.93 Section 81.93 Housing and Urban Development Office of the Secretary... Procedures § 81.93 Creation of Participant's Security Entitlement; security interests. (a) A Participant's...

  13. 12 CFR 1249.13 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Creation of Participant's Security Entitlement; security interests. 1249.13 Section 1249.13 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES BOOK-ENTRY PROCEDURES § 1249.13 Creation of Participant's Security Entitlement; security interests. (a...

  14. 10 CFR 1.1 - Creation and authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Creation and authority. 1.1 Section 1.1 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Introduction § 1.1 Creation and authority. (a) The Nuclear Regulatory Commission was established by the Energy Reorganization Act of 1974...

  15. 12 CFR 987.4 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Creation of Participant's Security Entitlement; security interests. 987.4 Section 987.4 Banks and Banking FEDERAL HOUSING FINANCE BOARD OFFICE OF FINANCE BOOK-ENTRY PROCEDURE FOR CONSOLIDATED OBLIGATIONS § 987.4 Creation of Participant's Security...

  16. 32 CFR 10.6 - Non-creation of right.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Non-creation of right. 10.6 Section 10.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS MILITARY COMMISSION INSTRUCTIONS § 10.6 Non-creation of right. Neither this part nor any Military Commission...

  17. 24 CFR 350.5 - Creation of Participant's Security Entitlement; Security Interests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Creation of Participant's Security Entitlement; Security Interests. 350.5 Section 350.5 Housing and Urban Development Regulations Relating to... AND URBAN DEVELOPMENT BOOK-ENTRY PROCEDURES § 350.5 Creation of Participant's Security Entitlement...

  18. 24 CFR 350.5 - Creation of Participant's Security Entitlement; Security Interests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Creation of Participant's Security Entitlement; Security Interests. 350.5 Section 350.5 Housing and Urban Development Regulations Relating to... AND URBAN DEVELOPMENT BOOK-ENTRY PROCEDURES § 350.5 Creation of Participant's Security Entitlement...

  19. 32 CFR 10.6 - Non-creation of right.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Non-creation of right. 10.6 Section 10.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS MILITARY COMMISSION INSTRUCTIONS § 10.6 Non-creation of right. Neither this part nor any Military Commission...

  20. 49 CFR 1150.34 - Caption summary-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Caption summary-transactions that involve creation of Class III carriers. 1150.34 Section 1150.34 Transportation Other Regulations Relating to....34 Caption summary—transactions that involve creation of Class III carriers. The caption summary must...

  1. 17 CFR 201.1100 - Creation of Fair Fund.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Creation of Fair Fund. 201.1100 Section 201.1100 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Fair Fund and Disgorgement Plans § 201.1100 Creation of Fair Fund. In any agency process initiated...

  2. 12 CFR 1270.14 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Creation of Participant's Security Entitlement; security interests. 1270.14 Section 1270.14 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS LIABILITIES Book-Entry Procedure for Consolidated Obligations § 1270.14 Creation of...

  3. 49 CFR 1150.34 - Caption summary-transactions that involve creation of Class III carriers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Caption summary-transactions that involve creation of Class III carriers. 1150.34 Section 1150.34 Transportation Other Regulations Relating to....34 Caption summary—transactions that involve creation of Class III carriers. The caption summary must...

  4. 24 CFR 81.93 - Creation of Participant's Security Entitlement; security interests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Creation of Participant's Security Entitlement; security interests. 81.93 Section 81.93 Housing and Urban Development Office of the Secretary... Procedures § 81.93 Creation of Participant's Security Entitlement; security interests. (a) A Participant's...

  5. 17 CFR 201.1100 - Creation of Fair Fund.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Creation of Fair Fund. 201.1100 Section 201.1100 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Fair Fund and Disgorgement Plans § 201.1100 Creation of Fair Fund. In any agency process initiated...

  6. 12 CFR 611.1040 - Creation of new associations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Creation of new associations. 611.1040 Section 611.1040 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Bank Mergers, Consolidations and Charter Amendments § 611.1040 Creation of new associations. Any application for the issuance...

  7. 32 CFR 10.6 - Non-creation of right.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Non-creation of right. 10.6 Section 10.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS MILITARY COMMISSION INSTRUCTIONS § 10.6 Non-creation of right. Neither this part nor any Military Commission...

  8. Value Co-Creation through Learning Styles Segmentation and Integrated Course Design

    ERIC Educational Resources Information Center

    Young, Mark; Collins, Marianne K.

    2014-01-01

    This paper describes an innovative Principles of Marketing course design and delivery which matches learning and teaching styles, while reducing multi-section variation. Value co-creation is encouraged by instructors and students collaborating in the creation of customized learning experiences which facilitates both teaching style and learning…

  9. Teaching About the Creation/Evolution Controversy. Fastback 134.

    ERIC Educational Resources Information Center

    Bergman, Jerry

    The booklet discusses questions related to teaching engendered by the creation/evolution controversy, presents current positions of educators and textbooks, and recommends a two-model teaching approach. It is divided into six chapters. Chapter I defines and summarizes evolution and creationism as different belief structures, and outlines various…

  10. Does Teaching Creationism Facilitate Student Autonomy?

    ERIC Educational Resources Information Center

    Warnick, Bryan R.; Fooce, C. David

    2007-01-01

    The teaching of evolution in US public schools continues to generate controversy. One argument for including creationism in science classrooms is based on the goal of facilitating student autonomy. Autonomy requires that students be exposed to significant alternatives, it is argued, and religious creation stories offer a significant alternative to…

  11. 18 CFR 701.2 - Creation and basic authority.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 2 2013-04-01 2012-04-01 true Creation and basic authority. 701.2 Section 701.2 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Introduction § 701.2 Creation and basic authority. The Water Resources Council was established by...

  12. 18 CFR 701.2 - Creation and basic authority.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Creation and basic authority. 701.2 Section 701.2 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Introduction § 701.2 Creation and basic authority. The Water Resources Council was established by...

  13. 18 CFR 701.2 - Creation and basic authority.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Creation and basic authority. 701.2 Section 701.2 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Introduction § 701.2 Creation and basic authority. The Water Resources Council was established by...

  14. 18 CFR 701.2 - Creation and basic authority.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Creation and basic authority. 701.2 Section 701.2 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Introduction § 701.2 Creation and basic authority. The Water Resources Council was established by...

  15. 18 CFR 701.2 - Creation and basic authority.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 2 2014-04-01 2014-04-01 false Creation and basic authority. 701.2 Section 701.2 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COUNCIL ORGANIZATION Introduction § 701.2 Creation and basic authority. The Water Resources Council was established by...

  16. Global Optimization of Interplanetary Trajectories in the Presence of Realistic Mission Constraints

    NASA Technical Reports Server (NTRS)

    Hinckley, David; Englander, Jacob; Hitt, Darren

    2015-01-01

    Single trial evaluations Trial creation by Phase-wise GA-style or DE-inspired recombination Bin repository structure requires an initialization period Non-exclusionary Kill Distance Population collapse mechanic Main loop Creation Probabilistic switch between GA and DE creation types Locally optimize Submit to repository Repeat.

  17. Relationships between Organizational Trust, Knowledge Transfer, Knowledge Creation, and Firm's Innovativeness

    ERIC Educational Resources Information Center

    Sankowska, Anna

    2013-01-01

    Purpose: This study seeks to provide empirical evidence of relationships between organizational trust, knowledge transfer, creation and innovativeness at the firm level. It aims to hypothesize a mediational model implying that organizational trust is related to knowledge transfer, which will, in turn, enhance knowledge creation, thereby…

  18. A Case Against Scientific Creationism: A Look at Content Issues.

    ERIC Educational Resources Information Center

    Kenkel, Father Leonard A.

    1985-01-01

    Discusses: (1) the theology of creation (religion); (2) evolution (science); and (3) scientific creationism (religious doctrine and pseudoscience). Points out that contrary to its claim, the latter is a sectarian religious doctrine in the guise of science demanding to be taught in the classroom "as a science." (JN)

  19. Knowledge Creation through User-Guided Data Mining: A Database Case

    ERIC Educational Resources Information Center

    Steiger, David M.

    2008-01-01

    This case focuses on learning by applying the four integrating mechanisms of Nonaka's knowledge creation theory: socialization, externalization, combination and internalization. In general, such knowledge creation and internalization (i.e., learning) is critical to database students since they will be expected to apply their specialized database…

  20. Gravitational particle creation in a stiff matter dominated universe

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lankinen, Juho; Vilja, Iiro, E-mail: jumila@utu.fi, E-mail: vilja@utu.fi

    A scenario for gravitational particle creation in a stiff matter dominated flat Friedmann-Robertson-Walker universe is presented. The primary creation of scalar particles is calculated using quantum field theory in curved spacetime and it is found to be strongly dependent on the scalar mass and the expansion parameter of the universe. The particle creation is most effective for a very massive scalar field and large expansion parameter. We demonstrate the phenomenon by applying it to cosmological toy model scenario, where secondary particles are created by the scalar field decay.

  1. Gravitational particle creation in a stiff matter dominated universe

    NASA Astrophysics Data System (ADS)

    Lankinen, Juho; Vilja, Iiro

    2017-08-01

    A scenario for gravitational particle creation in a stiff matter dominated flat Friedmann-Robertson-Walker universe is presented. The primary creation of scalar particles is calculated using quantum field theory in curved spacetime and it is found to be strongly dependent on the scalar mass and the expansion parameter of the universe. The particle creation is most effective for a very massive scalar field and large expansion parameter. We demonstrate the phenomenon by applying it to cosmological toy model scenario, where secondary particles are created by the scalar field decay.

  2. Transjugular intrahepatic portosystemic shunt creation using intravascular ultrasound guidance.

    PubMed

    Farsad, Khashayar; Fuss, Cristina; Kolbeck, Kenneth J; Barton, Robert E; Lakin, Paul C; Keller, Frederick S; Kaufman, John A

    2012-12-01

    To describe the use of intravascular ultrasound (US) guidance for creation of transjugular intrahepatic portosystemic shunts (TIPSs) in humans. The initial 25 cases of intravascular US-guided TIPS were retrospectively compared versus the last 75 conventional TIPS cases during the same time period at the same institution in terms of the number of needle passes required to establish portal vein (PV) access, fluoroscopy time, and needle pass-related complications. Intravascular US-guided TIPS creation was successful in all cases, and there was no statistically significant difference in number of needle passes, fluoroscopy time, or needle pass-related complications between TIPS techniques. Intravascular US-guided TIPS creation was successful in cases in which conventional TIPS creation had failed as a result of PV thrombosis or distorted anatomy. Intravascular US guidance for TIPS creation was additionally useful in a patient with Budd-Chiari syndrome and in a patient with intrahepatic tumors. Intravascular US is a safe and reproducible means of real-time image guidance for TIPS creation, equivalent in efficacy to conventional fluoroscopic guidance. Real-time sonographic guidance with intravascular US may prove advantageous for cases in which there is PV thrombus, distorted anatomy, Budd-Chiari syndrome, or hepatic tumors. Copyright © 2012 SIR. Published by Elsevier Inc. All rights reserved.

  3. Risk factors of stoma re-creation after closure of diverting ileostomy in patients with rectal cancer who underwent low anterior resection or intersphincteric resection with loop ileostomy.

    PubMed

    Song, Ook; Kim, Kyung Hwan; Lee, Soo Young; Kim, Chang Hyun; Kim, Young Jin; Kim, Hyeong Rok

    2018-04-01

    The aim of this study was to identify the risk factors of stoma re-creation after closure of diverting ileostomy in patients with rectal cancer who underwent low anterior resection (LAR) or intersphincteric resection (ISR) with loop ileostomy. We retrospectively reviewed 520 consecutive patients with rectal cancer who underwent LAR or ISR with loop ileostomy from January 2005 to December 2014 at Chonnam National University Hwasun Hospital. Risk factors for stoma re-creation after ileostomy closure were evaluated. Among 520 patients with rectal cancer who underwent LAR or ISR with loop ileostomy, 458 patients underwent stoma closure. Among these patients, 45 (9.8%) underwent stoma re-creation. The median period between primary surgery and stoma closure was 5.5 months (range, 0.5-78.3 months), and the median period between closure and re-creation was 6.8 months (range, 0-71.5 months). Stoma re-creation was performed because of anastomosis-related complications (26, 57.8%), local recurrence (15, 33.3%), and anal sphincter dysfunction (3, 6.7%). Multivariate analysis showed that independent risk factors for stoma re-creation were anastomotic leakage (odds ratio [OR], 4.258; 95% confidence interval [CI], 1.814-9.993), postoperative radiotherapy (OR, 3.947; 95% CI, 1.624-9.594), and ISR (OR, 3.293; 95% CI, 1.462-7.417). Anastomotic leakage, postoperative radiotherapy, and ISR were independent risk factors for stoma re-creation after closure of ileostomy in patients with rectal cancer.

  4. Proponents of Creationism but not Proponents of Evolution Frame the Origins Debate in Terms of Proof

    NASA Astrophysics Data System (ADS)

    Barnes, Ralph M.; Church, Rebecca A.

    2013-03-01

    In Study 1, 72 internet documents containing creationism, ID (intelligent design), or evolution content were selected for analysis. All instances of proof cognates (the word "proof" and related terms such as "proven", "disproof", etc.) contained within these documents were identified and labeled in terms of the manner in which the terms were used. In Study 2, frequency counts for six terms (proof, evidence, establish, experiment, test, trial) were conducted on a sample of peer-reviewed research articles in the journal Science and the 72 internet documents included in Study 1. Quantitative and qualitative analyses revealed that proponents of creationism were much more likely than proponents of evolution to frame the creationism/evolution issue in terms of proof (ID proponents fell partway between the other two). Proponents of creationism frequently described empirical data favoring their position as proof of their position. Even more frequently, proponents of creationism described evolutionary scientists as being engaged in failed attempts to prove the truth of the evolutionary position. Evolution documents included fewer proof cognates than creationism or ID documents and the few proof cognates found in evolution documents were rarely used to describe the status of the theory of evolution. Qualitative data analysis indicated that proof cognates were often used to indicate certainty. The asymmetry between evolution and creationism documents was limited primarily to proof cognates; there were no major asymmetries for the terms evidence, establish, experiment, test, and trial. The results may reveal differences in the epistemological commitments of the involved parties.

  5. The Co-Creation-Wheel: A Four-Dimensional Model of Collaborative Interorganistional Innovation

    ERIC Educational Resources Information Center

    Ehlen, Corry; van der Klink, Marcel; Stoffers, Jol; Boshuizen, Henny

    2017-01-01

    Purpose: This study aims to design and validate a conceptual and practical model of co-creation. Co-creation, to design collaborative new products, services and processes in contact with users, has become more and more important because organisations increasingly require multidisciplinary collaboration inside and outside the organisation to…

  6. Value co-creation platform design within the context of technology-driven businesses

    NASA Astrophysics Data System (ADS)

    Tanev, Stoyan; Ruskov, Petko

    2010-02-01

    The article provides a discussion of value co-creation platforms within the context of technology driven business. It emphasizes the need for a terminological refinement of the value co-creation paradigm as well as for an articulation of its implications for the design and reconfiguration of the company value network.

  7. Science and Creation: Geological, Theological & Educational Perspectives.

    ERIC Educational Resources Information Center

    Hanson, Robert W., Ed.

    This book provides working examples of how different teachers, scientists, and theologians have dealt with problems of "creation science" versus evolutionary concepts. A 1982 symposia on the topic of science and creation was so well received that the participants were asked to submit formal presentations; this book is a collection of these papers.…

  8. Rural Job Creation. Case Studies of CETA Linkage with Economic Development.

    ERIC Educational Resources Information Center

    Bruno, A. Lee; Wright, L. M., Jr.

    This collection contains 20 case studies illustrating some of the contributions Comprehensive Employment and Training Act (CETA) programs have made to economic development and job creation efforts in rural areas. The collection is a companion volume to the monograph entitled "Rural Job Creation--a Study of CETA Linkages with Economic…

  9. Scopes II. The Great Debate. Creation vs. Evolution.

    ERIC Educational Resources Information Center

    Keith, Bill

    This book, written by a member of the Louisiana State Legislature (who authored a bill during the 1981 legislative session mandating balanced treatment for creation-science wherever evolution-science is taught to public school children), takes a step toward answering the question: Should the scientific evidences for creation be given equal time…

  10. 22 CFR 8.5 - Creation of a committee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Creation of a committee. 8.5 Section 8.5 Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.5 Creation of a committee. (a) A bureau or an office designated or desiring to sponsor an advisory committee will prepare a...

  11. An Efficacious Measurement of Learning Initiatives: E-Learning Systems, Learning-Organization Culture, Knowledge Creation, and Innovativeness

    ERIC Educational Resources Information Center

    Grundhoefer, Raymie

    2013-01-01

    The purpose of this research is twofold: (a) develop a validated measure for learning initiatives based on knowledge-creation theory and (b) conduct a quantitative study to investigate the relationships between electronic learning systems, learning-organization culture, efficacious knowledge creation (EKC), and innovativeness. Although Cheng-Chang…

  12. 34 CFR 5.15 - Creation of records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Creation of records. 5.15 Section 5.15 Education Office of the Secretary, Department of Education AVAILABILITY OF INFORMATION TO THE PUBLIC PURSUANT TO PUB. L. 90-23 (Eff. until 7-14-10) What Records Are Available § 5.15 Creation of records. Records are not...

  13. 34 CFR 5.12 - Creation of agency records not required.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 1 2012-07-01 2012-07-01 false Creation of agency records not required. 5.12 Section 5.12 Education Office of the Secretary, Department of Education AVAILABILITY OF INFORMATION TO THE PUBLIC Agency Records Available to the Public § 5.12 Creation of agency records not required. In response...

  14. 41 CFR 102-193.10 - What are the goals of the Federal Records Management Program?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATIVE PROGRAMS 193-CREATION, MAINTENANCE, AND USE OF RECORDS § 102-193.10 What are the goals of the... maintenance of management controls that prevent the creation of unnecessary records and promote effective and... creation, maintenance, and use. (e) Judicious preservation and disposal of records. (f) Direction of...

  15. 41 CFR 102-193.10 - What are the goals of the Federal Records Management Program?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATIVE PROGRAMS 193-CREATION, MAINTENANCE, AND USE OF RECORDS § 102-193.10 What are the goals of the... maintenance of management controls that prevent the creation of unnecessary records and promote effective and... creation, maintenance, and use. (e) Judicious preservation and disposal of records. (f) Direction of...

  16. 22 CFR 8.5 - Creation of a committee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Creation of a committee. 8.5 Section 8.5 Foreign Relations DEPARTMENT OF STATE GENERAL ADVISORY COMMITTEE MANAGEMENT § 8.5 Creation of a committee. (a) A bureau or an office designated or desiring to sponsor an advisory committee will prepare a...

  17. 14 CFR § 1206.203 - Creation of records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Creation of records. § 1206.203 Section § 1206.203 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.203 Creation of records. Records will not be...

  18. 34 CFR 5.12 - Creation of agency records not required.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Creation of agency records not required. 5.12 Section 5.12 Education Office of the Secretary, Department of Education AVAILABILITY OF INFORMATION TO THE PUBLIC Agency Records Available to the Public § 5.12 Creation of agency records not required. In response...

  19. 5 CFR 2634.404 - Summary of procedures for creation of a qualified trust.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Summary of procedures for creation of a qualified trust. 2634.404 Section 2634.404 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT... Trusts § 2634.404 Summary of procedures for creation of a qualified trust. (a) Consultation with the...

  20. 40 CFR 98.120 - Definition of the source category.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... does not include the reuse or recycling of a fluorinated gas, the creation of HFC-23 during the production of HCFC-22, the creation of intermediates that are created and transformed in a single process with no storage of the intermediates, or the creation of fluorinated GHGs that are released or...

  1. 34 CFR 5.12 - Creation of agency records not required.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Creation of agency records not required. 5.12 Section 5.12 Education Office of the Secretary, Department of Education AVAILABILITY OF INFORMATION TO THE PUBLIC Agency Records Available to the Public § 5.12 Creation of agency records not required. In response...

  2. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  3. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  4. 41 CFR 102-193.10 - What are the goals of the Federal Records Management Program?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATIVE PROGRAMS 193-CREATION, MAINTENANCE, AND USE OF RECORDS § 102-193.10 What are the goals of the... maintenance of management controls that prevent the creation of unnecessary records and promote effective and... creation, maintenance, and use. (e) Judicious preservation and disposal of records. (f) Direction of...

  5. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  6. 41 CFR 102-193.10 - What are the goals of the Federal Records Management Program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ADMINISTRATIVE PROGRAMS 193-CREATION, MAINTENANCE, AND USE OF RECORDS § 102-193.10 What are the goals of the... maintenance of management controls that prevent the creation of unnecessary records and promote effective and... creation, maintenance, and use. (e) Judicious preservation and disposal of records. (f) Direction of...

  7. 40 CFR 98.120 - Definition of the source category.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... does not include the reuse or recycling of a fluorinated gas, the creation of HFC-23 during the production of HCFC-22, the creation of intermediates that are created and transformed in a single process with no storage of the intermediates, or the creation of fluorinated GHGs that are released or...

  8. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  9. 34 CFR 5.12 - Creation of agency records not required.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false Creation of agency records not required. 5.12 Section 5.12 Education Office of the Secretary, Department of Education AVAILABILITY OF INFORMATION TO THE PUBLIC Agency Records Available to the Public § 5.12 Creation of agency records not required. In response...

  10. 40 CFR 98.120 - Definition of the source category.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... does not include the reuse or recycling of a fluorinated gas, the creation of HFC-23 during the production of HCFC-22, the creation of intermediates that are created and transformed in a single process with no storage of the intermediates, or the creation of fluorinated GHGs that are released or...

  11. 5 CFR 2634.404 - Summary of procedures for creation of a qualified trust.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Summary of procedures for creation of a qualified trust. 2634.404 Section 2634.404 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT... Trusts § 2634.404 Summary of procedures for creation of a qualified trust. (a) Consultation with the...

  12. 40 CFR 98.120 - Definition of the source category.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... does not include the reuse or recycling of a fluorinated gas, the creation of HFC-23 during the production of HCFC-22, the creation of intermediates that are created and transformed in a single process with no storage of the intermediates, or the creation of fluorinated GHGs that are released or...

  13. 28 CFR 600.10 - No creation of rights.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false No creation of rights. 600.10 Section 600.10 Judicial Administration OFFICES OF INDEPENDENT COUNSEL, DEPARTMENT OF JUSTICE GENERAL POWERS OF SPECIAL COUNSEL § 600.10 No creation of rights. The regulations in this part are not intended to, do not...

  14. Evolutionary Creation: Moving beyond the Evolution versus Creation Debate

    ERIC Educational Resources Information Center

    Lamoureux, Denis O.

    2010-01-01

    Evolutionary creation offers a conservative Christian approach to evolution. It explores biblical faith and evolutionary science through a Two Divine Books model and proposes a complementary relationship between Scripture and science. The Book of God's Words discloses the spiritual character of the world, while the Book of God's Works reveals the…

  15. 78 FR 47433 - GENCAP Strategies LLC, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ... from, the series in connection with the purchase and redemption of Creation Units; and (e) certain... will range from $20 to $200. All orders to purchase Creation Units must be placed with the Distributor... agreement with the Distributor with respect to the purchase and redemption of Creation Units. 7. Shares will...

  16. Change Creation: The Rest of the Planning Story.

    ERIC Educational Resources Information Center

    Lick, Dale W.; Kaufman, Roger

    2001-01-01

    Introduces a new, comprehensive planning and change concept for universities, "change creation," that encompasses both strategic planning and a transition process for the organization from "what is" to "what should be." After exploring change, why it often fails, and the tenets of change creation, presents its steps. A few are: leadership team…

  17. Job Creation: The Role of Local and State Leaders in Vocational Education.

    ERIC Educational Resources Information Center

    Russell, Earl B.

    Vocational education can contribute to the creation of new jobs through educational programs for employers or prospective employers and through collaborative efforts with community leaders. Local leadership is the most essential ingredient in successful job creation programs at the community level. Local leaders can work to obtain baseline…

  18. Evolution, Creationism, and the Courts: 20 Questions

    ERIC Educational Resources Information Center

    Moore, Randy; Miksch, Karen L.

    2003-01-01

    The teaching of evolution and creationism is controversial to many people in the United States. Knowledge of the many important court-decisions about the teaching of evolution and creationism in the United States can be used not only to resist anti-evolution activities of creationists, but also to help teachers address questions about the teaching…

  19. Creationism as a Misconception: Socio-Cognitive Conflict in the Teaching of Evolution

    ERIC Educational Resources Information Center

    Foster, Colin

    2012-01-01

    This position paper argues that students' understanding and acceptance of evolution may be supported, rather than hindered, by classroom discussion of creationism. Parallels are drawn between creationism and other scientific misconceptions, both of the scientific community in the past and of students in the present. Science teachers frequently…

  20. Assessing Large-Scale Public Job Creation. R&D Monograph 67.

    ERIC Educational Resources Information Center

    Employment and Training Administration (DOL), Washington, DC.

    To assess the feasibility of large-scale, countercyclical public job creation, a study was initiated. Job creation program activities were examined in terms of how many activities could be undertaken; what would be their costs; and what would be their characteristics (labor-intensity, skill-mix, and political acceptability) that might contribute…

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