Sample records for series study design

  1. 76 FR 27637 - Supplemental Priorities for Discretionary Grant Programs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    .... Interrupted time series design means a type of quasi-experimental study (as defined in this notice) in which... design is an adaptation of an interrupted time series design that relies on the comparison of treatment... notice), interrupted time series designs (as defined in this notice), or regression discontinuity designs...

  2. 76 FR 32171 - Applications for New Awards; Investing in Innovation Fund

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... conflict of interest. Interrupted time series design \\5\\ means a type of quasi- experimental study in... single case design is an adaptation of an interrupted time series design that relies on the comparison of...), interrupted time series designs (as defined in this notice), or regression discontinuity designs (as defined...

  3. 76 FR 32159 - Applications for New Awards; Investing in Innovation Fund

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... conflict of interest. Interrupted time series design \\5\\ means a type of quasi- experimental study in which... design is an adaptation of an interrupted time series design that relies on the comparison of treatment...), interrupted time series designs (as defined in this notice), or regression discontinuity designs (as defined...

  4. Causal Inference and the Comparative Interrupted Time Series Design: Findings from Within-Study Comparisons

    ERIC Educational Resources Information Center

    St. Clair, Travis; Hallberg, Kelly; Cook, Thomas D.

    2014-01-01

    Researchers are increasingly using comparative interrupted time series (CITS) designs to estimate the effects of programs and policies when randomized controlled trials are not feasible. In a simple interrupted time series design, researchers compare the pre-treatment values of a treatment group time series to post-treatment values in order to…

  5. 76 FR 32148 - Applications for New Awards; Investing in Innovation Fund

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    .... Interrupted time series design \\5\\ means a type of quasi- experimental study in which the outcome of interest... interrupted time series design that relies on the comparison of treatment effects on a single subject or group... matched comparison group designs (as defined in this notice), interrupted time series designs (as defined...

  6. What's in a Name? The Incorrect Use of Case Series as a Study Design Label in Studies Involving Dogs and Cats.

    PubMed

    Sargeant, J M; O'Connor, A M; Cullen, J N; Makielski, K M; Jones-Bitton, A

    2017-07-01

    Study design labels are used to identify relevant literature to address specific clinical and research questions and to aid in evaluating the evidentiary value of research. Evidence from the human healthcare literature indicates that the label "case series" may be used inconsistently and inappropriately. Our primary objective was to determine the proportion of studies in the canine and feline veterinary literature labeled as case series that actually corresponded to descriptive cohort studies, population-based cohort studies, or other study designs. Our secondary objective was to identify the proportion of case series in which potentially inappropriate inferential statements were made. Descriptive evaluation of published literature. One-hundred published studies (from 19 journals) labeled as case series. Studies were identified by a structured literature search, with random selection of 100 studies from the relevant citations. Two reviewers independently characterized each study, with disagreements resolved by consensus. Of the 100 studies, 16 were case series. The remaining studies were descriptive cohort studies (35), population-based cohort studies (36), or other observational or experimental study designs (13). Almost half (48.8%) of the case series or descriptive cohort studies, with no control group and no formal statistical analysis, included inferential statements about the efficacy of treatment or statistical significance of potential risk factors. Authors, peer-reviewers, and editors should carefully consider the design elements of a study to accurately identify and label the study design. Doing so will facilitate an understanding of the evidentiary value of the results. Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

  7. 76 FR 9331 - Professional Development for Arts Educators Program; Office of Innovation and Improvement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ... adaptation of an interrupted time series design that relies on the comparison of treatment effects on a... group designs (as defined in this notice), interrupted time series designs (as defined in this notice... series design means a type of quasi-experimental study (as defined in this notice) in which the outcome...

  8. Case reports and case series in prehospital emergency care research.

    PubMed

    Patterson, P Daniel; Weaver, Matthew; Clark, Sunday; Yealy, Donald M

    2010-11-01

    Research begins with a clearly stated question, problem or hypothesis. The selection of a study design appropriate to the task is the next key step. This paper provides guidance for the use of case report and case series designs by describing the 'what', 'when' and 'how' of both designs. Also described is the use of case reports and case series study designs in prehospital emergency research and the quality of published literature from 2000 to mid-2008.

  9. Human Mars Lander Design for NASA's Evolvable Mars Campaign

    NASA Technical Reports Server (NTRS)

    Polsgrove, Tara; Chapman, Jack; Sutherlin, Steve; Taylor, Brian; Fabisinski, Leo; Collins, Tim; Cianciolo Dwyer, Alicia; Samareh, Jamshid; Robertson, Ed; Studak, Bill; hide

    2016-01-01

    Landing humans on Mars will require entry, descent, and landing capability beyond the current state of the art. Nearly twenty times more delivered payload and an order of magnitude improvement in precision landing capability will be necessary. To better assess entry, descent, and landing technology options and sensitivities to future human mission design variations, a series of design studies on human-class Mars landers has been initiated. This paper describes the results of the first design study in the series of studies to be completed in 2016 and includes configuration, trajectory and subsystem design details for a lander with Hypersonic Inflatable Aerodynamic Decelerator (HIAD) entry technology. Future design activities in this series will focus on other entry technology options.

  10. The Design of Time-Series Comparisons under Resource Constraints.

    ERIC Educational Resources Information Center

    Willemain, Thomas R.; Hartunian, Nelson S.

    1982-01-01

    Two methods for dividing an interrupted time-series study between baseline and experimental phases when study resources are limited are compared. In fixed designs, the baseline duration is predetermined. In flexible designs the baseline duration is contingent on remaining resources and the match of results to prior expectations of the evaluator.…

  11. Teacher Challenges to Implement Engineering Design in Secondary Technology Education

    ERIC Educational Resources Information Center

    Kelley, Todd R.; Wicklein, Robert C.

    2009-01-01

    This descriptive study examined the current status of technology education teacher practices with respect to engineering design. This article is the third article in a three-part series presenting the results of this study. The first article in the series titled "Examination of Engineering Design Curriculum Content" highlighted the research…

  12. The Validity and Precision of the Comparative Interrupted Time Series Design and the Difference-in-Difference Design in Educational Evaluation

    ERIC Educational Resources Information Center

    Somers, Marie-Andrée; Zhu, Pei; Jacob, Robin; Bloom, Howard

    2013-01-01

    In this paper, we examine the validity and precision of two nonexperimental study designs (NXDs) that can be used in educational evaluation: the comparative interrupted time series (CITS) design and the difference-in-difference (DD) design. In a CITS design, program impacts are evaluated by looking at whether the treatment group deviates from its…

  13. The Validity and Precision of the Comparative Interrupted Time-Series Design: Three Within-Study Comparisons

    ERIC Educational Resources Information Center

    St. Clair, Travis; Hallberg, Kelly; Cook, Thomas D.

    2016-01-01

    We explore the conditions under which short, comparative interrupted time-series (CITS) designs represent valid alternatives to randomized experiments in educational evaluations. To do so, we conduct three within-study comparisons, each of which uses a unique data set to test the validity of the CITS design by comparing its causal estimates to…

  14. Using Time-Series Research Designs to Investigate the Effects of Instruction on SLA.

    ERIC Educational Resources Information Center

    Mellow, J. Dean; And Others

    1996-01-01

    Argues that the study of second-language acquisition theory can be enhanced through time-series research designs. Within the context of investigating the effects of second-language instruction, four main reasons for using T-S design are identified. (95 references) (Author/CK)

  15. 76 FR 71341 - BASINS and WEPP Climate Assessment Tools: Case Study Guide to Potential Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... report presents a series of short case studies designed to illustrate the capabilities of these tools for... change impacts on water. This report presents a series of short case studies using the BASINS and WEPP climate assessment tools. The case studies are designed to illustrate the capabilities of these tools for...

  16. A Time Series Design Study of Neurologically Impaired Children.

    ERIC Educational Resources Information Center

    St. John, Patricia

    1992-01-01

    Used time series design, Change-over-Time, study to determine usefulness of four tasks in distinguishing maturational factors and neurological characteristics of eight boys diagnosed as neurologically impaired. Results indicated that tasks were characterized by use of regular art materials, interest to subjects, ability to be replicated, and…

  17. Testing the effectiveness of family therapeutic assessment: a case study using a time-series design.

    PubMed

    Smith, Justin D; Wolf, Nicole J; Handler, Leonard; Nash, Michael R

    2009-11-01

    We describe a family Therapeutic Assessment (TA) case study employing 2 assessors, 2 assessment rooms, and a video link. In the study, we employed a daily measures time-series design with a pretreatment baseline and follow-up period to examine the family TA treatment model. In addition to being an illustrative addition to a number of clinical reports suggesting the efficacy of family TA, this study is the first to apply a case-based time-series design to test whether family TA leads to clinical improvement and also illustrates when that improvement occurs. Results support the trajectory of change proposed by Finn (2007), the TA model's creator, who posits that benefits continue beyond the formal treatment itself.

  18. Associations of daily pediatric asthma emergency department visits with air pollution in Newark, NJ: utilizing time-series and case-crossover study designs.

    PubMed

    Gleason, Jessie A; Fagliano, Jerald A

    2015-10-01

    Asthma is one of the most common chronic diseases affecting children. This study assesses the associations of ozone and fine particulate matter (PM2.5) with pediatric emergency department visits in the urban environment of Newark, NJ. Two study designs were utilized and evaluated for usability. We obtained daily emergency department visits among children aged 3-17 years with a primary diagnosis of asthma during April to September for 2004-2007. Both a time-stratified case-crossover study design with bi-directional control sampling and a time-series study design were utilized. Lagged effects (1-d through 5-d lag, 3-d average, and 5-d average) of ozone and PM2.5 were explored and a dose-response analysis comparing the bottom 5th percentile of 3-d average lag ozone with each 5 percentile increase was performed. Associations of interquartile range increase in same-day ozone were similar between the time-series and case-crossover study designs (RR = 1.08, 95% CI 1.04-1.12) and (OR = 1.10, 95% CI 1.06-1.14), respectively. Similar associations were seen for 1-day lag and 3-day average lag ozone levels. PM2.5 was not associated with the outcome in either study design. Dose-response assessment indicated a statistically significant and increasing association around 50-55 ppb consistent for both study designs. Ozone was statistically positively associated with pediatric asthma ED visits in Newark, NJ. Our results were generally comparable across the time-series and case-crossover study designs, indicating both are useful to assess local air pollution impacts.

  19. A systematic review on the use of time series data in the study of antimicrobial consumption and Pseudomonas aeruginosa resistance.

    PubMed

    Athanasiou, Christos I; Kopsini, Angeliki

    2018-06-12

    In the field of antimicrobial resistance, the number of studies that use time series data has increased recently. The purpose of this study is the systematic review of all studies on antibacterial consumption and on Pseudomonas aeruginosa resistance in healthcare settings, that have used time series data. A systematic review of the literature till June 2017 was conducted. All the studies that have used time series data and have examined the inhospital antibiotic consumption and Ps. aeruginosa resistance rates or incidence were eligible. No other exclusion criteria were applied. Data on the structure, terminology used, methods used and results of each article were recorded and analyzed as possible. A total of thirty six studies were retrieved, twenty three of which were in accordance with our criteria. Thirteen of them were quasi experimental studies and ten were ecological observational studies. Eighteen studies collected time series data of both parameters and the statistical methodology of "time series analysis" was applied in nine studies. Most of the studies were published in the last eight years. The Interrupted Time Series design was the most widespread. As expected, there was high heterogeneity in regard to the study design, terminology and statistical methods applied. Copyright © 2018. Published by Elsevier Ltd.

  20. Evolution of the Instructional Design in a Series of Online Workshops

    ERIC Educational Resources Information Center

    Patry, Anne; Brown, Elizabeth Campbell; Rousseau, Rémi; Caron, Jeanette

    2015-01-01

    This case recounts the story of the design and production of a series of online workshops for French-speaking healthcare professionals in Canada. The project spans a couple of years and, despite encountering some challenges, succeeds in large part because of its strong foundation: the instructional design. This case study features an instructional…

  1. Computational Fluid Dynamics (CFD) investigation onto passenger car disk brake design

    NASA Astrophysics Data System (ADS)

    Munisamy, Kannan M.; Kanasan Moorthy, Shangkari K.

    2013-06-01

    The aim of this study is to investigate the flow and heat transfer in ventilated disc brakes using Computational Fluid Dynamics (CFD). NACA Series blade is designed for ventilated disc brake and the cooling characteristic is compared to the baseline design. The ventilated disc brakes are simulated using commercial CFD software FLUENTTM using simulation configuration that was obtained from experiment data. The NACA Series blade design shows improvements in Nusselt number compared to baseline design.

  2. Curriculum and Design Analysis of a Mathematics-Based Educational Television Program: A Case Study of Cyberchase Animated Television Series

    ERIC Educational Resources Information Center

    Yusop, Farrah Dina

    2013-01-01

    This paper presents a curriculum and design analyses of an Emmy-award winning children educational television series, Cyberchase. Using Posner's (2004) four process of curriculum analysis framework, this paper addresses each of the components and relates it to the design principles undertaken by the Cyberchase production team. Media and document…

  3. Interrupted time series regression for the evaluation of public health interventions: a tutorial.

    PubMed

    Bernal, James Lopez; Cummins, Steven; Gasparrini, Antonio

    2017-02-01

    Interrupted time series (ITS) analysis is a valuable study design for evaluating the effectiveness of population-level health interventions that have been implemented at a clearly defined point in time. It is increasingly being used to evaluate the effectiveness of interventions ranging from clinical therapy to national public health legislation. Whereas the design shares many properties of regression-based approaches in other epidemiological studies, there are a range of unique features of time series data that require additional methodological considerations. In this tutorial we use a worked example to demonstrate a robust approach to ITS analysis using segmented regression. We begin by describing the design and considering when ITS is an appropriate design choice. We then discuss the essential, yet often omitted, step of proposing the impact model a priori. Subsequently, we demonstrate the approach to statistical analysis including the main segmented regression model. Finally we describe the main methodological issues associated with ITS analysis: over-dispersion of time series data, autocorrelation, adjusting for seasonal trends and controlling for time-varying confounders, and we also outline some of the more complex design adaptations that can be used to strengthen the basic ITS design.

  4. Interrupted time series regression for the evaluation of public health interventions: a tutorial

    PubMed Central

    Bernal, James Lopez; Cummins, Steven; Gasparrini, Antonio

    2017-01-01

    Abstract Interrupted time series (ITS) analysis is a valuable study design for evaluating the effectiveness of population-level health interventions that have been implemented at a clearly defined point in time. It is increasingly being used to evaluate the effectiveness of interventions ranging from clinical therapy to national public health legislation. Whereas the design shares many properties of regression-based approaches in other epidemiological studies, there are a range of unique features of time series data that require additional methodological considerations. In this tutorial we use a worked example to demonstrate a robust approach to ITS analysis using segmented regression. We begin by describing the design and considering when ITS is an appropriate design choice. We then discuss the essential, yet often omitted, step of proposing the impact model a priori. Subsequently, we demonstrate the approach to statistical analysis including the main segmented regression model. Finally we describe the main methodological issues associated with ITS analysis: over-dispersion of time series data, autocorrelation, adjusting for seasonal trends and controlling for time-varying confounders, and we also outline some of the more complex design adaptations that can be used to strengthen the basic ITS design. PMID:27283160

  5. The Prediction of Teacher Turnover Employing Time Series Analysis.

    ERIC Educational Resources Information Center

    Costa, Crist H.

    The purpose of this study was to combine knowledge of teacher demographic data with time-series forecasting methods to predict teacher turnover. Moving averages and exponential smoothing were used to forecast discrete time series. The study used data collected from the 22 largest school districts in Iowa, designated as FACT schools. Predictions…

  6. A scan statistic for identifying optimal risk windows in vaccine safety studies using self-controlled case series design.

    PubMed

    Xu, Stanley; Hambidge, Simon J; McClure, David L; Daley, Matthew F; Glanz, Jason M

    2013-08-30

    In the examination of the association between vaccines and rare adverse events after vaccination in postlicensure observational studies, it is challenging to define appropriate risk windows because prelicensure RCTs provide little insight on the timing of specific adverse events. Past vaccine safety studies have often used prespecified risk windows based on prior publications, biological understanding of the vaccine, and expert opinion. Recently, a data-driven approach was developed to identify appropriate risk windows for vaccine safety studies that use the self-controlled case series design. This approach employs both the maximum incidence rate ratio and the linear relation between the estimated incidence rate ratio and the inverse of average person time at risk, given a specified risk window. In this paper, we present a scan statistic that can identify appropriate risk windows in vaccine safety studies using the self-controlled case series design while taking into account the dependence of time intervals within an individual and while adjusting for time-varying covariates such as age and seasonality. This approach uses the maximum likelihood ratio test based on fixed-effects models, which has been used for analyzing data from self-controlled case series design in addition to conditional Poisson models. Copyright © 2013 John Wiley & Sons, Ltd.

  7. Design considerations for case series models with exposure onset measurement error.

    PubMed

    Mohammed, Sandra M; Dalrymple, Lorien S; Sentürk, Damla; Nguyen, Danh V

    2013-02-28

    The case series model allows for estimation of the relative incidence of events, such as cardiovascular events, within a pre-specified time window after an exposure, such as an infection. The method requires only cases (individuals with events) and controls for all fixed/time-invariant confounders. The measurement error case series model extends the original case series model to handle imperfect data, where the timing of an infection (exposure) is not known precisely. In this work, we propose a method for power/sample size determination for the measurement error case series model. Extensive simulation studies are used to assess the accuracy of the proposed sample size formulas. We also examine the magnitude of the relative loss of power due to exposure onset measurement error, compared with the ideal situation where the time of exposure is measured precisely. To facilitate the design of case series studies, we provide publicly available web-based tools for determining power/sample size for both the measurement error case series model as well as the standard case series model. Copyright © 2012 John Wiley & Sons, Ltd.

  8. GPS Position Time Series @ JPL

    NASA Technical Reports Server (NTRS)

    Owen, Susan; Moore, Angelyn; Kedar, Sharon; Liu, Zhen; Webb, Frank; Heflin, Mike; Desai, Shailen

    2013-01-01

    Different flavors of GPS time series analysis at JPL - Use same GPS Precise Point Positioning Analysis raw time series - Variations in time series analysis/post-processing driven by different users. center dot JPL Global Time Series/Velocities - researchers studying reference frame, combining with VLBI/SLR/DORIS center dot JPL/SOPAC Combined Time Series/Velocities - crustal deformation for tectonic, volcanic, ground water studies center dot ARIA Time Series/Coseismic Data Products - Hazard monitoring and response focused center dot ARIA data system designed to integrate GPS and InSAR - GPS tropospheric delay used for correcting InSAR - Caltech's GIANT time series analysis uses GPS to correct orbital errors in InSAR - Zhen Liu's talking tomorrow on InSAR Time Series analysis

  9. Secondary School Advanced Mathematics, Chapter 8, Systems of Equations. Teacher's Commentary.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. School Mathematics Study Group.

    This manual was designed for use with the last of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered in…

  10. Secondary School Advanced Mathematics, Chapter 3, Formal Geometry. Teacher's Commentary.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. School Mathematics Study Group.

    This manual was designed for use with the second of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered…

  11. A Rhetorical and Structural Analysis of Instructional Television.

    ERIC Educational Resources Information Center

    Salcedo, Anunciacion M.

    The educational television series "Across Cultures" was evaluated to examine the effectiveness of the series and how the programs were structured to attain objectives. Designed to complement sixth- and seventh-grade social studies textbooks, the series on world cultures is composed of thirteen 15-minute programs about three widely…

  12. Therapeutic Assessment for Preadolescent Boys with Oppositional Defiant Disorder: A Replicated Single-Case Time-Series Design

    ERIC Educational Resources Information Center

    Smith, Justin D.; Handler, Leonard; Nash, Michael R.

    2010-01-01

    The Therapeutic Assessment (TA) model is a relatively new treatment approach that fuses assessment and psychotherapy. The study examines the efficacy of this model with preadolescent boys with oppositional defiant disorder and their families. A replicated single-case time-series design with daily measures is used to assess the effects of TA and to…

  13. 26 CFR 56.4911-2 - Lobbying expenditures, direct lobbying communications, and grass roots lobbying communications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... eligible to be considered as part of a series. If an electing organization times or channels a part of a series which is described in this paragraph (c)(1)(iii) in a manner designed to influence the general... project is not within the exception for nonpartisan analysis, study, or research because it is designed to...

  14. 26 CFR 56.4911-2 - Lobbying expenditures, direct lobbying communications, and grass roots lobbying communications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... eligible to be considered as part of a series. If an electing organization times or channels a part of a series which is described in this paragraph (c)(1)(iii) in a manner designed to influence the general... project is not within the exception for nonpartisan analysis, study, or research because it is designed to...

  15. 26 CFR 56.4911-2 - Lobbying expenditures, direct lobbying communications, and grass roots lobbying communications.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... eligible to be considered as part of a series. If an electing organization times or channels a part of a series which is described in this paragraph (c)(1)(iii) in a manner designed to influence the general... project is not within the exception for nonpartisan analysis, study, or research because it is designed to...

  16. Quasi-experimental study designs series-paper 7: assessing the assumptions.

    PubMed

    Bärnighausen, Till; Oldenburg, Catherine; Tugwell, Peter; Bommer, Christian; Ebert, Cara; Barreto, Mauricio; Djimeu, Eric; Haber, Noah; Waddington, Hugh; Rockers, Peter; Sianesi, Barbara; Bor, Jacob; Fink, Günther; Valentine, Jeffrey; Tanner, Jeffrey; Stanley, Tom; Sierra, Eduardo; Tchetgen, Eric Tchetgen; Atun, Rifat; Vollmer, Sebastian

    2017-09-01

    Quasi-experimental designs are gaining popularity in epidemiology and health systems research-in particular for the evaluation of health care practice, programs, and policy-because they allow strong causal inferences without randomized controlled experiments. We describe the concepts underlying five important quasi-experimental designs: Instrumental Variables, Regression Discontinuity, Interrupted Time Series, Fixed Effects, and Difference-in-Differences designs. We illustrate each of the designs with an example from health research. We then describe the assumptions required for each of the designs to ensure valid causal inference and discuss the tests available to examine the assumptions. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. ACC Study Guide Series (Revised Edition).

    ERIC Educational Resources Information Center

    Staples, Katherine; And Others

    Designed for the beginning college student who needs to search for information, prepare written assignments, or take tests, the ACC (Austin Community College) Study Guide Series comprises 17 one-page study guides. Printed on card stock with colored headings, the guides are highlighted with cartoon illustrations and are intended to provide…

  18. 75 FR 47284 - Secretary's Priorities for Discretionary Grant Programs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... the most currently available data. Interrupted time series design \\4\\ means a type of quasi... findings. \\4\\ A single subject or single case design is an adaptation of an interrupted time series design...), interrupted time series designs (as defined in this notice), or regression discontinuity designs (as defined...

  19. Trade-offs: What the Research Is Saying.

    ERIC Educational Resources Information Center

    Shea, James

    "Trade-offs" is an instructional television series of 15 programs designed to improve and expand economics instruction in fifth and sixth grade classrooms in the United States and Canada. This paper reviews 15 studies that have examined the impact of the "Trade-off" series, and seeks to determine how the series affects student…

  20. 26 CFR 53.4945-2 - Propaganda influencing legislation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... qualify as “nonpartisan analysis, study, or research”. (iii) Presentation as part of a series. Normally... months will ordinarily be eligible to be considered as part of a series. If a private foundation times or channels a part of a series which is described in this subdivision in a manner designed to influence the...

  1. Native Americans; A Bibliography for Young People. Bibliographic Series #7.

    ERIC Educational Resources Information Center

    Fuson, Elgie M., Comp.

    Early in 1969, the Sacramento State College Library began a series of bibliographies designed to aid its patrons in making more effective use of existing library resources. This publication, Number 7 of that series directed specifically to areas involved in the college's developing ethnic studies programs, cites materials published between 1905…

  2. 77 FR 64029 - Special Conditions: Airbus Model A318, A319, A320, and A321 Series Airplanes; Design Dive Speed

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... Series Airplanes; Design Dive Speed AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final... Model A318, A319, A320, and A321 series airplanes because of a novel or unusual design feature, special... Unusual Design Features The Airbus Model A318, A319, and A320 series airplanes with modification 160500...

  3. Therapeutic assessment for preadolescent boys with oppositional defiant disorder: a replicated single-case time-series design.

    PubMed

    Smith, Justin D; Handler, Leonard; Nash, Michael R

    2010-09-01

    The Therapeutic Assessment (TA) model is a relatively new treatment approach that fuses assessment and psychotherapy. The study examines the efficacy of this model with preadolescent boys with oppositional defiant disorder and their families. A replicated single-case time-series design with daily measures is used to assess the effects of TA and to track the process of change as it unfolds. All 3 families benefitted from participation in TA across multiple domains of functioning, but the way in which change unfolded was unique for each family. These findings are substantiated by the Behavior Assessment System for Children (Reynolds & Kamphaus, 2004). The TA model is shown to be an effective treatment for preadolescent boys with oppositional defiant disorder and their families. Further, the time-series design of this study illustrated how this empirically grounded case-based methodology reveals when and how change unfolds during treatment in a way that is usually not possible with other research designs.

  4. Parameters Design of Series Resonant Inverter Circuit

    NASA Astrophysics Data System (ADS)

    Qi, Xingkun; Peng, Yonglong; Li, Yabin

    This paper analyzes the main circuit structure of series resonant inverter, and designs the components parameters of the main circuit.That provides a theoretical method for the design of series resonant inverter.

  5. Design of an Active Bumper with a Series Elastic Actuator for Pedestrian Protection of Small Unmanned Vehicles

    NASA Astrophysics Data System (ADS)

    Terumasa, Narukawa; Tomoki, Tsuge; Hiroshi, Yamamoto; Takahiro, Suzuki

    2016-09-01

    When autonomous unmanned vehicles are operated on sidewalks, the vehicles must have high safety standards such as avoiding injury when they come in contact with pedestrians. In this study, we established a design for preventing serious injury when such collisions occur. We designed an active bumper with a series elastic actuator, with the goal of avoiding serious injury to a pedestrian in a collision with a small unmanned vehicle. The series elastic actuator comprised an elastic element in series with a table driven by a ball screw and servo motor. The active bumper was used to control the contact force between a vehicle and a pedestrian. The optimal force for minimizing the deflection of the object of the collision was derived, and the actuator controlled to apply this optimal force. Numerical simulations showed that the active bumper was successful in improving the collision safety of small unmanned vehicles.

  6. 77 FR 18229 - Applications for New Awards; Investing in Innovation Fund, Validation Grants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... the appearance of a conflict of interest. Interrupted time series design \\8\\ means a type of quasi... single case design is an adaptation of an interrupted time series design that relies on the comparison of... notice), interrupted time series designs (as defined in this notice), or regression discontinuity designs...

  7. 77 FR 18216 - Applications for New Awards; Investing in Innovation Fund, Scale-Up Grants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... evaluation and prevents even the appearance of a conflict of interest. Interrupted time series design \\8... findings. \\8\\ A single subject or single case design is an adaptation of an interrupted time series design... matched comparison group designs (as defined in this notice), interrupted time series designs (as defined...

  8. Learning and Celebrating: The Glamour of Design Lecture Series

    ERIC Educational Resources Information Center

    Popov, Lubomir

    2013-01-01

    The purpose of this paper is to highlight the celebratory aspect of the Design Lecture Series, a tradition in architecture schools and interior design programs, its meaning for all constituent parties, and its contributions to creating professional identity and community. The Design Lecture Series is a public event popular in design programs,…

  9. Secondary School Advanced Mathematics, Chapter 4, Equations, Inequalities, and Radicals, Chapter 5, Circles and Spheres. Teacher's Commentary.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. School Mathematics Study Group.

    This manual was designed for use with the third of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered in…

  10. Secondary School Advanced Mathematics, Chapter 1, Organizing Geometric Knowledge, Chapter 2, Concepts and Skills in Algebra. Teacher's Commentary.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. School Mathematics Study Group.

    This manual was designed for use with the first of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered in…

  11. 76 FR 23821 - Agency Information Collection Activities; Proposed Collection; Comment Request; Examination of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... solicits comments on a series of studies, Examination of Online Direct-to-Consumer Prescription Drug Promotion. These studies are designed to test different ways of presenting benefit and risk information in.... This dynamic is shifting, and evidence is needed to support guidance development. The series of studies...

  12. Host-Guest Complexes with Protein-Ligand-Like Affinities: Computational Analysis and Design

    PubMed Central

    Moghaddam, Sarvin; Inoue, Yoshihisa

    2009-01-01

    It has recently been discovered that guests combining a nonpolar core with cationic substituents bind cucurbit[7]uril (CB[7]) in water with ultra-high affinities. The present study uses the Mining Minima algorithm to study the physics of these extraordinary associations and to computationally test a new series of CB[7] ligands designed to bind with similarly high affinity. The calculations reproduce key experimental observations regarding the affinities of ferrocene-based guests with CB[7] and β-cyclodextrin and provide a coherent view of the roles of electrostatics and configurational entropy as determinants of affinity in these systems. The newly designed series of compounds is based on a bicyclo[2.2.2]octane core, which is similar in size and polarity to the ferrocene core of the existing series. Mining Minima predicts that these new compounds will, like the ferrocenes, bind CB[7] with extremely high affinities. PMID:19133781

  13. 76 FR 25674 - Notice of Submission for OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... for the rigorous comparative interrupted time series design including student records data collection...- experimental designs to explore the relationship between magnet programs and student achievement both for... this study. An OMB clearance request that (1) described the study design and full data collection...

  14. 77 FR 11087 - Applications for New Awards; Investing in Innovation Fund, Development Grants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... prevents even the appearance of a conflict of interest. Interrupted time series design \\8\\ means a type of.... \\8\\ A single subject or single case design is an adaptation of an interrupted time series design that... matched comparison group designs (as defined in this notice), interrupted time series designs (as defined...

  15. 75 FR 12072 - Office of Innovation and Improvement; Overview Information: Investing in Innovation Fund; Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... matched comparison group designs (as defined in this notice), interrupted time series designs (as defined... reading skills administered in the same way to both groups). Interrupted time series design \\3\\ means a... findings. \\3\\ A single subject or single case design is an adaptation of an interrupted time series design...

  16. 78 FR 36084 - Special Conditions: The Boeing Company, Model 717-200 Series Airplanes; Seats With Inflatable...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... 717- 200 series airplanes. These airplanes will have a novel or unusual design feature [[Page 36085... series airplanes will incorporate the following novel or unusual design features: inflatable lapbelts on... certain novel or unusual design features on one model series of airplanes. It is not a rule of general...

  17. 78 FR 68775 - Special Conditions: Airbus, Model A350-900 Series Airplane; Composite Fuselage In-Flight Fire...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... Model A350-900 series airplanes. This airplane will have a novel or unusual design features associated... Model A350-900 series because of a novel or unusual design feature, special conditions are prescribed... Airbus Model A350-900 series airplane will incorporate the following novel or unusual design features...

  18. 78 FR 76980 - Special Conditions: Airbus, A350-900 Series Airplane; Interaction of Systems and Structures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... series airplanes. These airplanes will have novel or unusual design features when compared to the state...-900 series because of a novel or unusual design feature, special conditions are prescribed under Sec...)(2). Novel or Unusual Design Features The Airbus Model A350-900 series will incorporate the following...

  19. Evaluating the Impact of Database Heterogeneity on Observational Study Results

    PubMed Central

    Madigan, David; Ryan, Patrick B.; Schuemie, Martijn; Stang, Paul E.; Overhage, J. Marc; Hartzema, Abraham G.; Suchard, Marc A.; DuMouchel, William; Berlin, Jesse A.

    2013-01-01

    Clinical studies that use observational databases to evaluate the effects of medical products have become commonplace. Such studies begin by selecting a particular database, a decision that published papers invariably report but do not discuss. Studies of the same issue in different databases, however, can and do generate different results, sometimes with strikingly different clinical implications. In this paper, we systematically study heterogeneity among databases, holding other study methods constant, by exploring relative risk estimates for 53 drug-outcome pairs and 2 widely used study designs (cohort studies and self-controlled case series) across 10 observational databases. When holding the study design constant, our analysis shows that estimated relative risks range from a statistically significant decreased risk to a statistically significant increased risk in 11 of 53 (21%) of drug-outcome pairs that use a cohort design and 19 of 53 (36%) of drug-outcome pairs that use a self-controlled case series design. This exceeds the proportion of pairs that were consistent across databases in both direction and statistical significance, which was 9 of 53 (17%) for cohort studies and 5 of 53 (9%) for self-controlled case series. Our findings show that clinical studies that use observational databases can be sensitive to the choice of database. More attention is needed to consider how the choice of data source may be affecting results. PMID:23648805

  20. Spacecraft (Mobile Satellite) configuration design study

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The relative costs to procure and operate a two-satellite mobile satellite system designed to operate either in the UHF band of the L Band, and with several antenna diameter options in each frequency band was investigated. As configured, the size of the spacecraft is limited to the current RCA Series 4000 Geosynchronous Communications Spacecraft bus, which spans the range from 4000 to 5800 pounds in the transfer orbit. The Series 4000 bus forms the basis around which the Mobile Satellite transponder and associated antennas were appended. Although the resultant configuration has little outward resemblance to the present Series 4000 microwave communications spacecraft, the structure, attitude control, thermal, power, and command and control subsystems of the Series 4000 spacecraft are all adapted to support the Mobile Satellite mission.

  1. Modelling short time series in metabolomics: a functional data analysis approach.

    PubMed

    Montana, Giovanni; Berk, Maurice; Ebbels, Tim

    2011-01-01

    Metabolomics is the study of the complement of small molecule metabolites in cells, biofluids and tissues. Many metabolomic experiments are designed to compare changes observed over time under two or more experimental conditions (e.g. a control and drug-treated group), thus producing time course data. Models from traditional time series analysis are often unsuitable because, by design, only very few time points are available and there are a high number of missing values. We propose a functional data analysis approach for modelling short time series arising in metabolomic studies which overcomes these obstacles. Our model assumes that each observed time series is a smooth random curve, and we propose a statistical approach for inferring this curve from repeated measurements taken on the experimental units. A test statistic for detecting differences between temporal profiles associated with two experimental conditions is then presented. The methodology has been applied to NMR spectroscopy data collected in a pre-clinical toxicology study.

  2. Interrupted time series design: a useful approach for studying interventions targeting participation.

    PubMed

    Anaby, Dana; Lal, Shalini; Huszczynski, Justine; Maich, Jana; Rogers, Jade; Law, Mary

    2014-11-01

    Comparative effectiveness research (CER) strives for evidence to inform clinical decisions for specific clients in typical health care settings. While the randomized controlled trial (RCT) is well-aligned with the objectives of CER, this design may not be feasible or applicable to all research questions, particularly those pertaining to clinical decision making and individually based change. It is important, therefore, to consider alternative approaches, especially when studying complex and subjective outcomes such as children's participation. We propose the use of interrupted time series (ITS) quasi-experimental design for its potential application in determining the effectiveness of participation-focused interventions. In this perspective, ITS design is described, ascertaining its advantages and limitations, and suggestions are provided to overcome challenges to implementation. Results of a case study using the ITS approach to evaluate changes in participation of an adolescent with physical disabilities are described. Finally, strategies to implement this design in practice are suggested.

  3. Secondary School Advanced Mathematics, Chapter 6, The Complex Number System, Chapter 7, Equations of the First and Second Degree in Two Variables. Teacher's Commentary.

    ERIC Educational Resources Information Center

    Stanford Univ., CA. School Mathematics Study Group.

    This manual was designed for use with the fourth of five texts in the Secondary School Advanced Mathematics (SSAM) series. Developed for students who have completed the Secondary School Mathematics (SSM) program and wish to continue their studies in mathematics, this series is designed to review, strengthen, and fill gaps in the material covered…

  4. Architecture as a Primary Source for Social Studies. How To Do It Series, Series 2, Number 5.

    ERIC Educational Resources Information Center

    Leclerc, Daniel C.

    Designed for elementary and secondary use in the social studies, this guide provides activities for learning the basic elements and the history of architecture. Through this study, students develop critical observation skills and investigate buildings as manifestations of religious, social, and personal values. The historical overview traces the…

  5. Just entertainment: effects of TV series about intrigue on young adults

    PubMed Central

    Wang, Fei; Lin, Shengdong; Ke, Xue

    2015-01-01

    The potential harmful effects of media violence have been studied systematically and extensively. However, very little attention has been devoted to the intrigue and struggles between people depicted in the mass media. A longitudinal randomized experimental group-control group, pretest–posttest design study was conducted to examine the potential effects of this type of TV series on young adults. A typical and popular TV series was select as a stimulus. By scrutinizing the outline of this TV series and inspired by studies of the effects of media violence, one behavioral observation and five scales were adopted as dependent measures. The study did not find any effect of the intrigue TV series on any of the six dependent variables. Finally, possible interference variables or moderators were discussed. PMID:26029127

  6. Exploring Collaboration in Learning by Design via Weblogs

    ERIC Educational Resources Information Center

    Çakiroglu, Ünal; Yildiz, Merve; Mazlum, Ebru; Turan Güntepe, Ebru; Aydin, Senay

    2017-01-01

    The purpose of this qualitative study was to explore collaborative activities that were carried out via weblogs according to a "learning by design" approach. During the instructional process, Microsoft Publisher was used for a series of infographic design activities. The study participants were 33 undergraduate students who were enrolled…

  7. Displacement and deformation measurement for large structures by camera network

    NASA Astrophysics Data System (ADS)

    Shang, Yang; Yu, Qifeng; Yang, Zhen; Xu, Zhiqiang; Zhang, Xiaohu

    2014-03-01

    A displacement and deformation measurement method for large structures by a series-parallel connection camera network is presented. By taking the dynamic monitoring of a large-scale crane in lifting operation as an example, a series-parallel connection camera network is designed, and the displacement and deformation measurement method by using this series-parallel connection camera network is studied. The movement range of the crane body is small, and that of the crane arm is large. The displacement of the crane body, the displacement of the crane arm relative to the body and the deformation of the arm are measured. Compared with a pure series or parallel connection camera network, the designed series-parallel connection camera network can be used to measure not only the movement and displacement of a large structure but also the relative movement and deformation of some interesting parts of the large structure by a relatively simple optical measurement system.

  8. Bridging CALL & HCI: Input from Participatory Design

    ERIC Educational Resources Information Center

    Cardenas-Claros, Monica S.; Gruba, Paul A.

    2010-01-01

    Participatory design (PD), or the collaboration between software engineers and end users throughout the design process, may help improve CALL design practices. In this case study, four ESL learners, a software designer, and a language teacher created and evaluated a series of paper prototypes concerning help options in computer-based second…

  9. 78 FR 75511 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... Design Features The C-series airplanes will incorporate the following novel or unusual design features: A.... Conclusion This action affects only certain novel or unusual design features on two model series of airplanes... Inc., Models BD-500-1A10 and BD- 500-1A11 Series Airplanes; Electronic Flight Control System: Control...

  10. Construct-a-Greenhouse. Science by Design Series.

    ERIC Educational Resources Information Center

    Lee, Felicia

    This book is one of four books in the Science-by-Design Series created by TERC and funded by the National Science Foundation (NSF). This series presents directed instruction on how to successfully formulate and carry out product design. Students learn and apply concepts in science and technology to design and build a pair of insulated gloves, a…

  11. Using machine learning to identify structural breaks in single-group interrupted time series designs.

    PubMed

    Linden, Ariel; Yarnold, Paul R

    2016-12-01

    Single-group interrupted time series analysis (ITSA) is a popular evaluation methodology in which a single unit of observation is being studied, the outcome variable is serially ordered as a time series and the intervention is expected to 'interrupt' the level and/or trend of the time series, subsequent to its introduction. Given that the internal validity of the design rests on the premise that the interruption in the time series is associated with the introduction of the treatment, treatment effects may seem less plausible if a parallel trend already exists in the time series prior to the actual intervention. Thus, sensitivity analyses should focus on detecting structural breaks in the time series before the intervention. In this paper, we introduce a machine-learning algorithm called optimal discriminant analysis (ODA) as an approach to determine if structural breaks can be identified in years prior to the initiation of the intervention, using data from California's 1988 voter-initiated Proposition 99 to reduce smoking rates. The ODA analysis indicates that numerous structural breaks occurred prior to the actual initiation of Proposition 99 in 1989, including perfect structural breaks in 1983 and 1985, thereby casting doubt on the validity of treatment effects estimated for the actual intervention when using a single-group ITSA design. Given the widespread use of ITSA for evaluating observational data and the increasing use of machine-learning techniques in traditional research, we recommend that structural break sensitivity analysis is routinely incorporated in all research using the single-group ITSA design. © 2016 John Wiley & Sons, Ltd.

  12. Liberating Learning Object Design from the Learning Style of Student Instructional Designers

    ERIC Educational Resources Information Center

    Akpinar, Yavuz

    2007-01-01

    Learning objects are a new form of learning resource, and the design of these digital environments has many facets. To investigate senior instructional design students' use of reflection tools in designing learning objects, a series of studies was conducted using the Reflective Action Instructional Design and Learning Object Review Instrument…

  13. The Value of Interrupted Time-Series Experiments for Community Intervention Research

    PubMed Central

    Biglan, Anthony; Ary, Dennis; Wagenaar, Alexander C.

    2015-01-01

    Greater use of interrupted time-series experiments is advocated for community intervention research. Time-series designs enable the development of knowledge about the effects of community interventions and policies in circumstances in which randomized controlled trials are too expensive, premature, or simply impractical. The multiple baseline time-series design typically involves two or more communities that are repeatedly assessed, with the intervention introduced into one community at a time. It is particularly well suited to initial evaluations of community interventions and the refinement of those interventions. This paper describes the main features of multiple baseline designs and related repeated-measures time-series experiments, discusses the threats to internal validity in multiple baseline designs, and outlines techniques for statistical analyses of time-series data. Examples are given of the use of multiple baseline designs in evaluating community interventions and policy changes. PMID:11507793

  14. An assessment of the validity and discrimination of the intensive time-series design by monitoring learning differences between students with different cognitive tendencies

    NASA Astrophysics Data System (ADS)

    Farnsworth, Carolyn H.; Mayer, Victor J.

    Intensive time-series designs for classroom investigations have been under development since 1975. Studies have been conducted to determine their feasibility (Mayer & Lewis, 1979), their potential for monitoring knowledge acquisition (Mayer & Kozlow, 1980), and the potential threat to validity of the frequency of testing inherent in the design (Mayer & Rojas, 1982). This study, an extension of those previous studies, is an attempt to determine the degree of discrimination the design allows in collecting data on achievement. It also serves as a replication of the Mayer and Kozlow study, an attempt to determine design validity for collecting achievement data. The investigator used her eighth-grade earth science students, from a suburban Columbus (Ohio) junior high school. A multiple-group single intervention time-series design (Glass, Willson, & Gottman, 1975) was adapted to the collection of daily data on achievement in the topic of the intervention, a unit on plate tectonics. Single multiple-choice items were randomly assigned to each of three groups of students, identified on the basis of their ranking on a written test of cognitive level (Lawson, 1978). The top third, or those with formal cognitive tendencies, were compared on the basis of knowledge achievement and understanding achievement with the lowest third of the students, or those with concrete cognitive tendencies, to determine if the data collected in the design would discriminate between the two groups. Several studies (Goodstein & Howe, 1978; Lawson & Renner, 1975) indicated that students with formal cognitive tendencies should learn a formal concept such as plate tectonics with greater understanding than should students with concrete cognitive tendencies. Analyses used were a comparison of regression lines in each of the three study stages: baseline, intervention, and follow-up; t-tests of means of days summed across each stage; and a time-series analysis program. Statistically significant differences were found between the two groups both in slopes of regression lines (0.0001) and in t-tests (0.0005) on both knowledge and understanding levels of learning. These differences confirm the discrimination of the intensive time-series design in showing that it can distinguish differences in learning between students with formal cognitive tendencies and those with concrete cognitive tendencies. The time-series analysis model with a trend in the intervention was better than a model with no trend for both groups of students, in that it accounted for a greater amount of variance in the data from both knowledge and understanding levels of learning. This finding adds additional confidence in the validity of the design for obtaining achievement data. When the analysis model with trend was used on data from the group with formal cognitive tendencies, it accounted for a greater degree of variance than the same model applied to the data from the group with concrete cognitive tendencies. This more conservative analysis, therefor, gave results consistent with those from the more usual linear regression techniques and t-tests, further adding to the confidence in the discrimination of the design.

  15. Structural reanalysis via a mixed method. [using Taylor series for accuracy improvement

    NASA Technical Reports Server (NTRS)

    Noor, A. K.; Lowder, H. E.

    1975-01-01

    A study is made of the approximate structural reanalysis technique based on the use of Taylor series expansion of response variables in terms of design variables in conjunction with the mixed method. In addition, comparisons are made with two reanalysis techniques based on the displacement method. These techniques are the Taylor series expansion and the modified reduced basis. It is shown that the use of the reciprocals of the sizing variables as design variables (which is the natural choice in the mixed method) can result in a substantial improvement in the accuracy of the reanalysis technique. Numerical results are presented for a space truss structure.

  16. Series: Pragmatic trials and real world evidence: Paper 1. Introduction.

    PubMed

    Zuidgeest, Mira G P; Goetz, Iris; Groenwold, Rolf H H; Irving, Elaine; van Thiel, Ghislaine J M W; Grobbee, Diederick E

    2017-08-01

    This is the introductory paper in a series of eight papers. In this series, we integrate the theoretical design options with the practice of conducting pragmatic trials. For most new market-approved treatments, the clinical evidence is insufficient to fully guide physicians and policy makers in choosing the optimal treatment for their patients. Pragmatic trials can fill this gap, by providing evidence on the relative effectiveness of a treatment strategy in routine clinical practice, already in an early phase of development, while maintaining the strength of randomized controlled trials. Selecting the setting, study population, mode of intervention, comparator, and outcome are crucial in designing pragmatic trials. In combination with monitoring and data collection that does not change routine care, this will enable appropriate generalization to the target patient group in clinical practice. To benefit from the full potential of pragmatic trials, there is a need for guidance and tools in designing these studies while ensuring operational feasibility. This paper introduces the concept of pragmatic trial design. The complex interplay between pragmatic design options, feasibility, stakeholder acceptability, validity, precision, and generalizability will be clarified. In this way, balanced design choices can be made in pragmatic trials with an optimal chance of success in practice. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Selection of Behavior Modification Programs Using the Simultaneous Treatment Design: Two Case Studies.

    ERIC Educational Resources Information Center

    Lowe, Warren C.

    This report outlines the limitations and weaknesses of singlecase, time-series research designs, of which the ABAB design is one of the widely used. An alternative design, the simultaneous treatment design, proposed by Browning and Stover (1971), has several advantages over the ABAB design. The design enables an experimenter to simultaneously…

  18. 29 CFR 1607.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in the design of the study and their effects identified. (5) Statistical relationships. The degree of...; or such factors should be included in the design of the study and their effects identified. (f... arduous effort involving a series of research studies, which include criterion related validity studies...

  19. 29 CFR 1607.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in the design of the study and their effects identified. (5) Statistical relationships. The degree of...; or such factors should be included in the design of the study and their effects identified. (f... arduous effort involving a series of research studies, which include criterion related validity studies...

  20. 29 CFR 1607.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in the design of the study and their effects identified. (5) Statistical relationships. The degree of...; or such factors should be included in the design of the study and their effects identified. (f... arduous effort involving a series of research studies, which include criterion related validity studies...

  1. 29 CFR 1607.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in the design of the study and their effects identified. (5) Statistical relationships. The degree of...; or such factors should be included in the design of the study and their effects identified. (f... arduous effort involving a series of research studies, which include criterion related validity studies...

  2. 29 CFR 1607.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... in the design of the study and their effects identified. (5) Statistical relationships. The degree of...; or such factors should be included in the design of the study and their effects identified. (f... arduous effort involving a series of research studies, which include criterion related validity studies...

  3. Skill Training Using Adaptive Technology: A Better Way to Hover

    DTIC Science & Technology

    2005-09-01

    instructional presentation strategies as discussed below. Primary Presentations Merrill’s CDT suggests that instruction be organized around a series of...conducted a series of experiments designed to investigate the application of Shiffrin and Schneider’s (1977) theory of automatic and controlled...perceptual-motor in content. The results of a series of interlocking studies, using various cognitive and perceptual-motor tasks and observational

  4. Development of a Design-Based Learning Curriculum through Design-Based Research for a Technology-Enabled Science Classroom

    ERIC Educational Resources Information Center

    Kim, Paul; Suh, Esther; Song, Donggil

    2015-01-01

    This exploratory study provides a deeper look into the aspects of students' experience from design-based learning (DBL) activities for fifth grade students. Using design-based research (DBR), this study was conducted on a series of science learning activities leveraging mobile phones with relevant applications and sensors. We observed 3 different…

  5. More on Time Series Designs: A Reanalysis of Mayer and Kozlow's Data.

    ERIC Educational Resources Information Center

    Willson, Victor L.

    1982-01-01

    Differentiating between time-series design and time-series analysis, examines design considerations and reanalyzes data previously reported by Mayer and Kozlow in this journal. The current analysis supports the analysis performed by Mayer and Kozlow but puts the results on a somewhat firmer statistical footing. (Author/JN)

  6. The Effects of Television Advertising on Children. Report No. 2: Second Year Experimental Evidence. Final Report.

    ERIC Educational Resources Information Center

    Atkin, Charles K.

    This report, the second in a series of six reports on television advertising and children, presents the results from a series of experimental studies designed to test children's intentional and incidental learning from television commercials. A total of 400 elementary school students of varying socioeconomic status participated in the study, with…

  7. Supervised Study Guide for Physical Therapy Aide (079.378). Texas Trade and Industrial Education Series.

    ERIC Educational Resources Information Center

    Jordan, Georgia S.; Dunn, Florence

    This study guide for the physical therapy aide, as one of a series designed to present related technical instruction to students in trade and industrial education, is intended for use under the direct supervision of a vocational instructor or instructor-coordinator. Developed by a materials specialist, this document contains a separate answer…

  8. Behavior Modification for Children with Autistic Tendencies; Study Guide for a Videotaped Series.

    ERIC Educational Resources Information Center

    Ackerman, Arthur; Dirr, Peter J.

    The study guide accompanies a series of 28 videotaped programs designed to provide teachers, teacher aides and parents with an understanding of children with autistic tendencies and of how behavior modification techniques might be used to train such children. Synopses of each program and each program segment and a few questions intended to…

  9. The Role of Graphic Elements in the Accurate Portrayal of Instructional Design.

    ERIC Educational Resources Information Center

    Branch, Robert C.; Bloom, Janet R.

    This study explores the interpretation of two types of flow diagrams composed of different visual elements intended to communicate the same meaning. Using linear and cyclical diagrams, the study focused on whether, given a series of diagrams using linear elements and a series using cyclical elements, both types of visuals convey the same message…

  10. Investigating the Impact of Cambridge International Assessments on U.S. Stakeholders: Student and Teacher Perceptions

    ERIC Educational Resources Information Center

    Shaw, Stuart

    2011-01-01

    As part of the continuing program to study the impact of its international assessments, the University of Cambridge International Examinations ("Cambridge") has undertaken a series of studies investigating the impact on a range of US stakeholders. This paper reports on research designed to respond to a series of washback and impact…

  11. Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents.

    PubMed

    Datar, Prasanna A; Limaye, Saleel A

    2015-01-01

    Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.

  12. Proton pump inhibitors and the risk of pneumonia: a comparison of cohort and self-controlled case series designs

    PubMed Central

    2013-01-01

    Background To compare the results of a new-user cohort study design and the self-controlled case series (SCCS) design using the risk of hospitalisation for pneumonia in those dispensed proton pump inhibitors compared to those unexposed as a case study. Methods The Australian Government Department of Veterans’ Affairs administrative claims database was used. Exposure to proton pump inhibitors and hospitalisations for pneumonia were identified over a 4 year study period 01 Jul 2007 -30 Jun 2011. The same inclusion and exclusion criteria were applied to both studies, however, the SCCS study included subjects with a least one hospitalisation for pneumonia. Results There were 105,467 subjects included in the cohort study and 6775 in the SCCS. Both studies showed an increased risk of hospitalisations for pneumonia in the three defined risk periods following initiation of proton pump inhibitors compared to baseline. With the highest risk in the first 1 to 7 days (Cohort RR, 3.24; 95% CI (2.50, 4.19): SCCS: RR, 3.07; 95% CI (2.69, 3.50)). Conclusions This study has shown that the self-controlled case series method produces similar risk estimates to a new-users cohort study design when applied to the association of proton pump inhibitors and pneumonia. Exposure to a proton pump inhibitor increases the likelihood of being admitted to hospital for pneumonia, with the risk highest in the first week of treatment. PMID:23800078

  13. Research on theoretical optimization and experimental verification of minimum resistance hull form based on Rankine source method

    NASA Astrophysics Data System (ADS)

    Zhang, Bao-Ji; Zhang, Zhu-Xin

    2015-09-01

    To obtain low resistance and high efficiency energy-saving ship, minimum total resistance hull form design method is studied based on potential flow theory of wave-making resistance and considering the effects of tail viscous separation. With the sum of wave resistance and viscous resistance as objective functions and the parameters of B-Spline function as design variables, mathematical models are built using Nonlinear Programming Method (NLP) ensuring the basic limit of displacement and considering rear viscous separation. We develop ship lines optimization procedures with intellectual property rights. Series60 is used as parent ship in optimization design to obtain improved ship (Series60-1) theoretically. Then drag tests for the improved ship (Series60-1) is made to get the actual minimum total resistance hull form.

  14. Designing and Proposing Your Research Project. Concise Guides to Conducting Behavioral, Health, and Social Science Research Series

    ERIC Educational Resources Information Center

    Urban, Jennifer Brown; van Eeden-Moorefield, Bradley Matheus

    2017-01-01

    Designing your own study and writing your research proposal takes time, often more so than conducting the study. This practical, accessible guide walks you through the entire process. You will learn to identify and narrow your research topic, develop your research question, design your study, and choose appropriate sampling and measurement…

  15. 78 FR 19468 - Applications for New Awards; Minority Science and Engineering Improvement Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    ... new immigrants, who are migrant, or who have disabilities. Interrupted time series design means a type... time series design that relies on the comparison of treatment effects on a single subject or group of... defined in this notice), interrupted time series designs (as defined in this notice), or regression...

  16. What Time-Series Designs May Have to Offer Educational Researchers.

    ERIC Educational Resources Information Center

    Kratochwill, Thomas R.; Levin, Joel R.

    1978-01-01

    The promise of time-series designs for educational research and evaluation is reviewed. Ten time-series designs are presented and discussed in the context of threats to internal and external validity. The advantages and disadvantages of various visual and statistical data-analysis techniques are presented. A bibliography is appended. (Author/RD)

  17. An approach to checking case-crossover analyses based on equivalence with time-series methods.

    PubMed

    Lu, Yun; Symons, James Morel; Geyh, Alison S; Zeger, Scott L

    2008-03-01

    The case-crossover design has been increasingly applied to epidemiologic investigations of acute adverse health effects associated with ambient air pollution. The correspondence of the design to that of matched case-control studies makes it inferentially appealing for epidemiologic studies. Case-crossover analyses generally use conditional logistic regression modeling. This technique is equivalent to time-series log-linear regression models when there is a common exposure across individuals, as in air pollution studies. Previous methods for obtaining unbiased estimates for case-crossover analyses have assumed that time-varying risk factors are constant within reference windows. In this paper, we rely on the connection between case-crossover and time-series methods to illustrate model-checking procedures from log-linear model diagnostics for time-stratified case-crossover analyses. Additionally, we compare the relative performance of the time-stratified case-crossover approach to time-series methods under 3 simulated scenarios representing different temporal patterns of daily mortality associated with air pollution in Chicago, Illinois, during 1995 and 1996. Whenever a model-be it time-series or case-crossover-fails to account appropriately for fluctuations in time that confound the exposure, the effect estimate will be biased. It is therefore important to perform model-checking in time-stratified case-crossover analyses rather than assume the estimator is unbiased.

  18. Design Considerations of Help Options in Computer-Based L2 Listening Materials Informed by Participatory Design

    ERIC Educational Resources Information Center

    Cárdenas-Claros, Mónica Stella

    2015-01-01

    This paper reports on the findings of two qualitative exploratory studies that sought to investigate design features of help options in computer-based L2 listening materials. Informed by principles of participatory design, language learners, software designers, language teachers, and a computer programmer worked collaboratively in a series of…

  19. 78 FR 76248 - Special Conditions: Airbus, Model A350-900 Series Airplane; Side Stick Controller

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-17

    ... control columns and wheels. This kind of controller is designed for only one-hand operation. The... same subject: For the Airbus Model A350-900 series airplane equipped with stick controls designed for... Airbus Model A350-900 series airplanes. These airplanes will have a novel or unusual design feature...

  20. FACTORS INFLUENCING THE DESIGN OF BIOACCUMULATION FACTOR AND BIOTA-SEDIMENT ACCUMULATION FACTOR FIELD STUDIES

    EPA Science Inventory

    General guidance for designing field studies to measure bioaccumulation factors (BAFs) and biota-sediment accumulation factors (BSAFs) is not available. To develop such guidance, a series of modeling simulations were performed to evaluate the underlying factors and principles th...

  1. Quasi-experimental study designs series-paper 6: risk of bias assessment.

    PubMed

    Waddington, Hugh; Aloe, Ariel M; Becker, Betsy Jane; Djimeu, Eric W; Hombrados, Jorge Garcia; Tugwell, Peter; Wells, George; Reeves, Barney

    2017-09-01

    Rigorous and transparent bias assessment is a core component of high-quality systematic reviews. We assess modifications to existing risk of bias approaches to incorporate rigorous quasi-experimental approaches with selection on unobservables. These are nonrandomized studies using design-based approaches to control for unobservable sources of confounding such as difference studies, instrumental variables, interrupted time series, natural experiments, and regression-discontinuity designs. We review existing risk of bias tools. Drawing on these tools, we present domains of bias and suggest directions for evaluation questions. The review suggests that existing risk of bias tools provide, to different degrees, incomplete transparent criteria to assess the validity of these designs. The paper then presents an approach to evaluating the internal validity of quasi-experiments with selection on unobservables. We conclude that tools for nonrandomized studies of interventions need to be further developed to incorporate evaluation questions for quasi-experiments with selection on unobservables. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Elections: Secondary Teaching Activities in the Participation Series.

    ERIC Educational Resources Information Center

    Schultz, John; Taft-Morales, Hugh

    One of a series of teacher-developed curriculum guides designed to encourage student participation and involvement in important social issues, this secondary level guide helps 7th through 12th grade English and social studies educators teach about the election process. An introductory section suggests practical considerations, means of enlisting…

  3. ACC Study Guide Series.

    ERIC Educational Resources Information Center

    Austin Community Coll., TX. Rio Grande Campus.

    Ten one-page instructional guides designed to assist Austin Community College (ACC) students in using the library and in writing research papers are presented in this series. The titles of the guides are: (1) "The Media Collection (We have more than books in the LRC)"; (2) "Encyclopedias"; (3) "Finding Books"; (4)…

  4. Ergonomic Based Design and Survey of Elementary School Furniture

    ERIC Educational Resources Information Center

    Maheshwar; Jawalkar, Chandrashekhar S.

    2014-01-01

    This paper presents the ergonomic aspects in designing and prototyping of desks cum chairs used in elementary schools. The procedures adopted for the assessment included: the study of existing school furniture, design analysis and development of prototypes. The design approach proposed a series of adjustable desks and chairs developed in terms of…

  5. Case Series in Cognitive Neuropsychology: Promise, Perils and Proper Perspective

    PubMed Central

    Rapp, Brenda

    2012-01-01

    Schwartz & Dell (2010) advocated for a major role for case series investigations in cognitive neuropsychology. They defined the key features of this approach and presented a number of arguments and examples illustrating the benefits of case series studies and their contribution to computational cognitive neuropsychology. In the Special Issue on “Case Series in Cognitive Neuropsychology” there are six commentaries on Schwartz and Dell (2010) as well as a response to the six commentaries by Dell and Schwartz. In this paper, I provide a brief summary of the key points made in Schwartz and Dell (2010) and I review the promise and perils of case series design as revealed by the six commentaries. I conclude by placing the set of papers within a broader perspective, providing some clarification of the historical record on case series and single case approaches, raising some cautionary notes for case series studies and situating both case series and single case approaches within the larger context of theory development in the cognitive sciences. PMID:22746685

  6. Systematic review of the methodological and reporting quality of case series in surgery.

    PubMed

    Agha, R A; Fowler, A J; Lee, S-Y; Gundogan, B; Whitehurst, K; Sagoo, H K; Jeong, K J L; Altman, D G; Orgill, D P

    2016-09-01

    Case series are an important and common study type. No guideline exists for reporting case series and there is evidence of key data being missed from such reports. The first step in the process of developing a methodologically sound reporting guideline is a systematic review of literature relevant to the reporting deficiencies of case series. A systematic review of methodological and reporting quality in surgical case series was performed. The electronic search strategy was developed by an information specialist and included MEDLINE, Embase, Cochrane Methods Register, Science Citation Index and Conference Proceedings Citation index, from the start of indexing to 5 November 2014. Independent screening, eligibility assessments and data extraction were performed. Included articles were then analysed for five areas of deficiency: failure to use standardized definitions, missing or selective data (including the omission of whole cases or important variables), transparency or incomplete reporting, whether alternative study designs were considered, and other issues. Database searching identified 2205 records. Through the process of screening and eligibility assessments, 92 articles met inclusion criteria. Frequencies of methodological and reporting issues identified were: failure to use standardized definitions (57 per cent), missing or selective data (66 per cent), transparency or incomplete reporting (70 per cent), whether alternative study designs were considered (11 per cent) and other issues (52 per cent). The methodological and reporting quality of surgical case series needs improvement. The data indicate that evidence-based guidelines for the conduct and reporting of case series may be useful. © 2016 BJS Society Ltd Published by John Wiley & Sons Ltd.

  7. Approximate techniques of structural reanalysis

    NASA Technical Reports Server (NTRS)

    Noor, A. K.; Lowder, H. E.

    1974-01-01

    A study is made of two approximate techniques for structural reanalysis. These include Taylor series expansions for response variables in terms of design variables and the reduced-basis method. In addition, modifications to these techniques are proposed to overcome some of their major drawbacks. The modifications include a rational approach to the selection of the reduced-basis vectors and the use of Taylor series approximation in an iterative process. For the reduced basis a normalized set of vectors is chosen which consists of the original analyzed design and the first-order sensitivity analysis vectors. The use of the Taylor series approximation as a first (initial) estimate in an iterative process, can lead to significant improvements in accuracy, even with one iteration cycle. Therefore, the range of applicability of the reanalysis technique can be extended. Numerical examples are presented which demonstrate the gain in accuracy obtained by using the proposed modification techniques, for a wide range of variations in the design variables.

  8. 78 FR 64415 - Special Conditions: Airbus, Model A350-900 Series Airplane; Ground Pivoting Loads

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ... series because of a novel or unusual design feature, special conditions are prescribed under Sec. 21.16... A350-900 series airplane will incorporate the following novel or unusual design features: a braking...-0890; Notice No. 25-13-10-SC] Special Conditions: Airbus, Model A350-900 Series Airplane; Ground...

  9. 78 FR 75287 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Flight...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ... appropriate safety standards for the C-series airplanes because of a novel or unusual design feature, special... Features The C-series airplanes will incorporate the following novel or unusual design features: new... Series Airplanes; Flight Envelope Protection: General Limiting Requirements AGENCY: Federal Aviation...

  10. 77 FR 64025 - Special Conditions: Airbus Model A318, A319, A320, and A321 Series Airplanes; Interaction of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... series airplanes with modification 160023 (Sharklet). These airplanes will have novel or unusual design... novel or unusual design features on the model series of airplanes listed above. It is not a rule of... Series Airplanes; Interaction of Systems and Structures AGENCY: Federal Aviation Administration (FAA...

  11. CBE Worplace Performance Webinar Series

    Science.gov Websites

    Speech Privacy Task Ambient Conditioning Team Space Design Study Thermal Comfort Automotive Research , Design and Evaluation Theory, tools and strategies to help professionals create and support successful Design With Science View slide presentation (PDF) Janice Barnes, PhD, LEED AP, Principal and Global

  12. 77 FR 34023 - Notice of Public Workshop: “Designing for Impact: Workshop on Building the National Network for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... series of public workshops entitled ``Designing for Impact: Workshop on Building the National Network for... Education and Workforce Development. The Designing for Impact workshop series is organized by... series will be held on Monday, July 9, 2012 from 8:00 a.m. until 4:30 p.m. Eastern time. Event check-in...

  13. Early phase drug discovery: cheminformatics and computational techniques in identifying lead series.

    PubMed

    Duffy, Bryan C; Zhu, Lei; Decornez, Hélène; Kitchen, Douglas B

    2012-09-15

    Early drug discovery processes rely on hit finding procedures followed by extensive experimental confirmation in order to select high priority hit series which then undergo further scrutiny in hit-to-lead studies. The experimental cost and the risk associated with poor selection of lead series can be greatly reduced by the use of many different computational and cheminformatic techniques to sort and prioritize compounds. We describe the steps in typical hit identification and hit-to-lead programs and then describe how cheminformatic analysis assists this process. In particular, scaffold analysis, clustering and property calculations assist in the design of high-throughput screening libraries, the early analysis of hits and then organizing compounds into series for their progression from hits to leads. Additionally, these computational tools can be used in virtual screening to design hit-finding libraries and as procedures to help with early SAR exploration. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Design-Based Research and Video Game Based Learning: Developing the Educational Video Game "Citizen Science"

    ERIC Educational Resources Information Center

    Gaydos, Matthew J.

    2013-01-01

    This paper presents a series of studies detailing the research and development of the educational science video game "Citizen Science." It documents the design process, beginning with the initial grant and ending with a case study of two teachers who used the game in their classrooms. Following a design-based research approach, this…

  15. The Status of Instructional Television; A Study of Instructional Television for Elementary and Secondary Schools During the First Semester of the School Year 1963-1964, with Supplementary Tables.

    ERIC Educational Resources Information Center

    National Instructional Television Library, New York, NY.

    Information for a tabular study of instructional television (ITV) series was supplied via questionnaire by 81 educational television stations, the Midwest Program on Airborne Television Instruction, 41 closed-circuit installations, and 51 commercial channels. Most of the series offerings (72%) were designed for elementary grades. Offerings for…

  16. False Dichotomies and Health Policy Research Designs: Randomized Trials Are Not Always the Answer.

    PubMed

    Soumerai, Stephen B; Ceccarelli, Rachel; Koppel, Ross

    2017-02-01

    Some medical scientists argue that only data from randomized controlled trials (RCTs) are trustworthy. They claim data from natural experiments and administrative data sets are always spurious and cannot be used to evaluate health policies and other population-wide phenomena in the real world. While many acknowledge biases caused by poor study designs, in this article we argue that several valid designs using administrative data can produce strong findings, particularly the interrupted time series (ITS) design. Many policy studies neither permit nor require an RCT for cause-and-effect inference. Framing our arguments using Campbell and Stanley's classic research design monograph, we show that several "quasi-experimental" designs, especially interrupted time series (ITS), can estimate valid effects (or non-effects) of health interventions and policies as diverse as public insurance coverage, speed limits, hospital safety programs, drug abuse regulation and withdrawal of drugs from the market. We further note the recent rapid uptake of ITS and argue for expanded training in quasi-experimental designs in medical and graduate schools and in post-doctoral curricula.

  17. 76 FR 13136 - Notice of Submission for OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... design; (3) analyze the impact of receipt of RTT funds on student outcomes using an interrupted time series design; and (4) investigate the relationship between STM turnaround models (and strategies within...-performing schools. The evaluation is designed to (1) study the implementation of RTT and SIG; (2) analyze...

  18. 76 FR 77503 - Notice of Submission for OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... series design; and (4) investigate the relationship between STM turnaround models (and strategies within...-performing schools. The evaluation is designed to (1) study the implementation of RTT and SIG; (2) analyze the impact of SIG- or RTT-funded STMs on student outcomes using a regression discontinuity design; (3...

  19. 75 FR 78230 - Notice of Proposed Information Collection Requests

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... discontinuity design; (3) analyze the impact of receipt of RTT funds on student outcomes using an interrupted time series design; and (4) investigate the relationship between STM turnaround models (and strategies... (STMs) in the lowest-performing schools. The evaluation is designed to (1) study the implementation of...

  20. Improving Children's Problem Eating and Mealtime Behaviours: An Evaluative Study of a Single Session Parent Education Programme

    ERIC Educational Resources Information Center

    Fraser, Kim; Wallis, Marianne; St. John, Winsome

    2004-01-01

    Objective: To evaluate the effectiveness of a "single session" group, early intervention, multidisciplinary, education programme (entitled the "Fun not Fuss with Food" group programme) designed to improve children's problem eating and mealtime behaviours. Design: A quasi-experimental time-series design incorporating data…

  1. Federal truck size and weight policy : looking beyond the comprehensive truck size and weight study : Irvine, California, May 10-11, 2000

    DOT National Transportation Integrated Search

    1997-05-01

    This document presents a series of five design examples illustrating the principles and methods of geotechnical earthquake engineering and seismic design for highway facilities. These principles and methods are described in Volume I - Design Principl...

  2. Induced static asymmetry of the pelvis is associated with functional asymmetry of the lumbo-pelvo-hip complex.

    PubMed

    Gnat, Rafał; Saulicz, Edward

    2008-03-01

    This study evaluates the hypothesis that triggering and eliminating induced static pelvic asymmetry (SPA) may be followed by immediate change in functional asymmetry of the lumbo-pelvo-hip complex. Repeated measures experimental design with 2 levels of independent variable, that is, induced SPA triggered and induced SPA eliminated, was implemented. Three series of measurements were performed, that is, baseline, after triggering SPA, and after eliminating SPA. A group of 84 subjects with no initial symptoms of SPA was studied. Different forms of mechanical stimulation were applied aiming to induce SPA, and the 2 manual stretching-manipulating techniques were performed aiming to eliminate it. A hand inclinometer was used to measure SPA in standing posture. Selected ranges of motion of the hip joints and lumbar spine were used to depict functional asymmetry of the lumbo-pelvo-hip complex. The functional asymmetry indices for individual movements were calculated. Repeated measures design of analysis of variance, dependent data Student t test, and linear Pearson's correlation test were used. Assessment of the SPA showed its significant increase between baseline and series 2 measurements, with a subsequent significant decrease between series 2 and series 3 measurements. Values of the functional asymmetry indices changed accordingly, that is, they increased significantly between series 1 and series 2 and had returned to their initial level in series 3 measurements. Induced SPA shows considerable association with functional asymmetry of the lumbo-pelvo-hip complex.

  3. Standards for Clinical Trials in Male and Female Sexual Dysfunction: III. Unique Aspects of Clinical Trials in Male Sexual Dysfunction.

    PubMed

    Fisher, William A; Gruenwald, Ilan; Jannini, Emmanuele A; Lev-Sagie, Ahinoam; Lowenstein, Lior; Pyke, Robert E; Reisman, Yakov; Revicki, Dennis A; Rubio-Aurioles, Eusebio

    2017-01-01

    This series of articles, Standards for Clinical Trials in Male and Female Sexual Dysfunction, began with the discussion of a common expected standard for clinical trial design in male and female sexual dysfunction, a common rationale for the design of phase I to IV clinical trials, and common considerations for the selection of study population and study duration in male and female sexual dysfunction. The second article in this series discussed fundamental principles in development, validation, and selection of patient- (and partner-) reported outcome assessment. The third and present article in this series discusses selected aspects of sexual dysfunction that are that are unique to male sexual dysfunctions and relevant to the conduct of clinical trials of candidate treatments for men. Copyright © 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

  4. The Comparative Rowhouse Study: An Introduction to Architectural Design.

    ERIC Educational Resources Information Center

    Hirshorn, Paul

    1982-01-01

    A course is described that involves a comparative study of Philadelphia rowhouses. Students each visit a house and complete its architectural drawing according to established guidelines. The drawings are later reduced and offset printed for sale. A series of exercises focuses on a number of design elements. (MSE)

  5. Toward automatic time-series forecasting using neural networks.

    PubMed

    Yan, Weizhong

    2012-07-01

    Over the past few decades, application of artificial neural networks (ANN) to time-series forecasting (TSF) has been growing rapidly due to several unique features of ANN models. However, to date, a consistent ANN performance over different studies has not been achieved. Many factors contribute to the inconsistency in the performance of neural network models. One such factor is that ANN modeling involves determining a large number of design parameters, and the current design practice is essentially heuristic and ad hoc, this does not exploit the full potential of neural networks. Systematic ANN modeling processes and strategies for TSF are, therefore, greatly needed. Motivated by this need, this paper attempts to develop an automatic ANN modeling scheme. It is based on the generalized regression neural network (GRNN), a special type of neural network. By taking advantage of several GRNN properties (i.e., a single design parameter and fast learning) and by incorporating several design strategies (e.g., fusing multiple GRNNs), we have been able to make the proposed modeling scheme to be effective for modeling large-scale business time series. The initial model was entered into the NN3 time-series competition. It was awarded the best prediction on the reduced dataset among approximately 60 different models submitted by scholars worldwide.

  6. Managing Vocational Education Programs. Vocational Education Curriculum Specialist, Module 14.

    ERIC Educational Resources Information Center

    Appleby, Judith A.

    One of five modules in the administrative series of the 16-module series designed to train vocational education curriculum specialists, this module is intended for use in classes or individual study arrangements at the preservice or inservice level by students with varying amounts of experience in vocational education. (These modules are revised…

  7. Global Issues 89/90. Fifth Edition. Annual Editions Series.

    ERIC Educational Resources Information Center

    Jackson, Robert, Ed.

    This book is one in a series designed to provide access to a wide range of selected articles from magazines, newspapers, and journals. This volume contains 55 articles by scientists, educators, researchers, and writers providing effective and useful perspectives on today's important topics in the study of global issues. Articles included in this…

  8. The Right to Live and Die. Canadian Critical Issues Series.

    ERIC Educational Resources Information Center

    Eisenberg, John; Bourne, Paula

    One of a series adapted from the Canadian Public Issues Project, this book is designed to stimulate discussion and reflection about controversial issues through case studies. The book is based on high school units originally drawn from cases in newspapers, journals, books, legal documents, and government reports. Conflicts from issues arising over…

  9. Priorities in Vocational Education. Vocational Education Curriculum Specialist, Module 5.

    ERIC Educational Resources Information Center

    Wheeler, Jeanette D.

    One of five modules in the foundation series of the 16-module series designed to train vocational education curriculum specialists, this module is intended for use in classes or individual study arrangements at the preservice or inservice level by students with varying amounts of experience in vocational education. (These modules are revised…

  10. The Scope of Vocational Education. Vocational Education Curriculum Specialist, Module 2.

    ERIC Educational Resources Information Center

    Wheeler, Jeanette D.

    One of five modules in the foundation series of the 16-module series designed to train vocational education curriculum specialists, this module is intended for use in classes or individual study arrangements at the preservice or inservice level by students with varying amounts of experience in vocational education. (These modules are revised…

  11. China, A Country Study. Area Handbook Series. Third Edition.

    ERIC Educational Resources Information Center

    Bunge, Frederica M., Ed.; Shinn, Rinn-Sup, Ed.

    Basic facts are given about the social, economic, political, and military institutions of China. The handbook, which is one of a continuing series designed for those interested in foreign affairs, is a revision of one published in 1972. The 1981 edition focuses on historical antecedents and China's new modernization strategies. Arranged into 14…

  12. 14 CFR 26.35 - Changes to type certificates affecting fuel tank flammability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...—Airbus A318, A319, A320, A321 Series A300, A310 Series A330, A340 Series (d) Design Changes and Service...) Applicability. This section applies to holders and applicants for approvals of the following design changes to any airplane subject to 14 CFR 26.33(a): (1) Any fuel tank designed to be Normally Emptied if the fuel...

  13. 14 CFR 26.35 - Changes to type certificates affecting fuel tank flammability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...—Airbus A318, A319, A320, A321 Series A300, A310 Series A330, A340 Series (d) Design Changes and Service...) Applicability. This section applies to holders and applicants for approvals of the following design changes to any airplane subject to 14 CFR 26.33(a): (1) Any fuel tank designed to be Normally Emptied if the fuel...

  14. 14 CFR 26.35 - Changes to type certificates affecting fuel tank flammability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...—Airbus A318, A319, A320, A321 Series A300, A310 Series A330, A340 Series (d) Design Changes and Service...) Applicability. This section applies to holders and applicants for approvals of the following design changes to any airplane subject to 14 CFR 26.33(a): (1) Any fuel tank designed to be Normally Emptied if the fuel...

  15. 14 CFR 26.35 - Changes to type certificates affecting fuel tank flammability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...—Airbus A318, A319, A320, A321 Series A300, A310 Series A330, A340 Series (d) Design Changes and Service...) Applicability. This section applies to holders and applicants for approvals of the following design changes to any airplane subject to 14 CFR 26.33(a): (1) Any fuel tank designed to be Normally Emptied if the fuel...

  16. 14 CFR 26.35 - Changes to type certificates affecting fuel tank flammability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...—Airbus A318, A319, A320, A321 Series A300, A310 Series A330, A340 Series (d) Design Changes and Service...) Applicability. This section applies to holders and applicants for approvals of the following design changes to any airplane subject to 14 CFR 26.33(a): (1) Any fuel tank designed to be Normally Emptied if the fuel...

  17. Standards for Clinical Trials in Male and Female Sexual Dysfunction: I. Phase I to Phase IV Clinical Trial Design.

    PubMed

    Fisher, William A; Gruenwald, Ilan; Jannini, Emmanuele A; Lev-Sagie, Ahinoam; Lowenstein, Lior; Pyke, Robert E; Reisman, Yakov; Revicki, Dennis A; Rubio-Aurioles, Eusebio

    2016-12-01

    This series of articles outlines standards for clinical trials of treatments for male and female sexual dysfunctions, with a focus on research design and patient-reported outcome assessment. These articles consist of revision, updating, and integration of articles on standards for clinical trials in male and female sexual dysfunction from the 2010 International Consultation on Sexual Medicine developed by the authors as part of the 2015 International Consultation on Sexual Medicine. We are guided in this effort by several principles. In contrast to previous versions of these guidelines, we merge discussion of standards for clinical trials in male and female sexual dysfunction in an integrated approach that emphasizes the common foundational practices that underlie clinical trials in the two settings. We present a common expected standard for clinical trial design in male and female sexual dysfunction, a common rationale for the design of phase I to IV clinical trials, and common considerations for selection of study population and study duration in male and female sexual dysfunction. We present a focused discussion of fundamental principles in patient- (and partner-) reported outcome assessment and complete this series of articles with specific discussions of selected aspects of clinical trials that are unique to male and to female sexual dysfunction. Our consideration of standards for clinical trials in male and female sexual dysfunction attempts to embody sensitivity to existing and new regulatory guidance and to address implications of the evolution of the diagnosis of sexual dysfunction that have been brought forward in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. The first article in this series focuses on phase I to phase IV clinical trial design considerations. Subsequent articles in this series focus on the measurement of patient-reported outcomes, unique aspects of clinical trial design for men, and unique aspects of clinical trial design for women. Copyright © 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

  18. Handbook for Using the Intensive Time-Series Design.

    ERIC Educational Resources Information Center

    Mayer, Victor J.; Monk, John S.

    Work on the development of the intensive time-series design was initiated because of the dissatisfaction with existing research designs. This dissatisfaction resulted from the paucity of data obtained from designs such as the pre-post and randomized posttest-only designs. All have the common characteristic of yielding data from only one or two…

  19. Retrofit and verification test of a 30-cm ion thruster

    NASA Technical Reports Server (NTRS)

    Dulgeroff, C. R.; Poeschel, R. L.

    1980-01-01

    Twenty modifications were found to be necessary and were approved by design review. These design modifications were incorporated in the thruster documents (drawings and procedures) to define the J series thruster. Sixteen of the design revisions were implemented in a 900 series thruster by retrofit modification. A standardized set of test procedures was formulated, and the retrofit J series thruster design was verified by test. Some difficulty was observed with the modification to the ion optics assembly, but the overall effect of the design modification satisfies the design objectives. The thruster was tested over a wide range of operating parameters to demonstrate its capabilities.

  20. Design and application of a new series of gallbladder endoscopes that facilitate gallstone removal without gallbladder excision

    NASA Astrophysics Data System (ADS)

    Qiao, Tie; Huang, Wan-Chao; Luo, Xiao-Bing; Zhang, Yang-De

    2012-01-01

    In recent years, some Chinese doctors have proposed a new concept, gallstone removal without gallbladder excision, along with transition of the medical model. As there is no specialized endoscope for gallstone removal without gallbladder excision, we designed and produced a new series of gallbladder endoscopes and accessories that have already been given a Chinese invention patent (No. ZL200810199041.2). The design of these gallbladder endoscopes was based on the anatomy and physiology of the gallbladder, characteristics of gallbladder disease, ergonomics, and industrial design. This series of gallbladder endoscopes underwent clinical trials in two hospitals appointed by the State Administration of Traditional Chinese Medicine. The clinical trials showed that surgeries of gallstones, gallbladder polyps, and cystic duct calculus could be smoothly performed with these products. In summary, this series of gallbladder endoscopes is safe, reliable, and effective for gallstone removal without gallbladder excision. This note comprehensively introduces the research and design of this series of gallbladder endoscopes.

  1. Designing and Financing an Integrated Program of College Study: Lessons from the California Academy of Liberal Studies

    ERIC Educational Resources Information Center

    Goldberger, Susan; Haynes, Leslie

    2005-01-01

    This document represents the first in a series of design briefs on models for early college high schools. The briefs focus on the academic and organizational design of the college component and tie those key features to a sustainable financing model. By engaging students in up to two years of demanding college-level work while still in high…

  2. Design a light pattern of multiple concentric circles for LED fishing lamps using Fourier series and an energy mapping method.

    PubMed

    Shen, S C; Li, J S; Huang, M C

    2014-06-02

    Fourier series and an energy mapping method were used in this study to design a lens that produces a light pattern of multiple concentric circles (LPMCC) for a light-emitting diode (LED) fishing lamp. Fourier series were used to represent the light intensity distribution curve (LIDC) of the LPMCC light pattern. Energy mapping involves performing angular energy mapping based on the LIDCs of an LED light source and LPMCC to design a freeform lens. Type I and Type II LPMCC lenses were designed according to the phototaxis behavior of fish to create a LPMCC light pattern of interleaving light-dark zones that attracts fish shoals to stay in an area for a long period. The experimental results indicated that, in comparing the LIDCs of the Type I and II lenses with the respective simulation values, the normalized cross-correlation (NCC) value reached 96%. According to a 24-hour observation of the phototaxis of Poecilia reticulata to evaluate the effectiveness of the proposed light pattern to attract fish, when a fish shoal was habituated to a light source that emitted constant illumination light, it gradually moved away from the intense light zone and hovered around the junction of the light and dark zones. In the future, the design used in this study can be applied to LED fishing lamps to replace traditional fishing lamps.

  3. Concept Learning by Direct Current Design Challenges in Secondary Education

    ERIC Educational Resources Information Center

    van Breukelen, Dave H. J.; de Vries, Marc J.; Schure, Frank A.

    2017-01-01

    This paper presents a mixed methods study in which 77 students and 3 teachers took part, that investigated the practice of Learning by Design (LBD). The study is part of a series of studies, funded by the Netherlands Organisation for Scientific Research, that aims to improve student learning, teaching skills and teacher training. LBD uses the…

  4. Use of Time-Series, ARIMA Designs to Assess Program Efficacy.

    ERIC Educational Resources Information Center

    Braden, Jeffery P.; And Others

    1990-01-01

    Illustrates use of time-series designs for determining efficacy of interventions with fictitious data describing drug-abuse prevention program. Discusses problems and procedures associated with time-series data analysis using Auto Regressive Integrated Moving Averages (ARIMA) models. Example illustrates application of ARIMA analysis for…

  5. A Study of the Effect of Proximally Autocorrelated Error on Tests of Significance for the Interrupted Time Series Quasi-Experimental Design.

    ERIC Educational Resources Information Center

    Sween, Joyce; Campbell, Donald T.

    The primary purpose of the present study was to investigate the appropriateness of several tests of significance for use with interrupted time series data. The second purpose was to determine what effect the violation of the assumption of uncorrelated error would have on the three tests of significance. The three tests were the Mood test,…

  6. A Time Series Study of Factors Associated with Retention and Attrition of Older Adult Child-Care Workers. Final Report.

    ERIC Educational Resources Information Center

    Newman, Sally; Engel, Rafael; Ward, Christopher; Karip, Emin; Faux, Robert

    The work-related and personal factors associated with the willingness and ability of older adults to remain as child care workers and the factors associated with leaving child care work were studied in a time-series design. Subjects were 534 persons aged 50 years and older who were working for pay as child care providers. Of these, 341 replied to…

  7. BASINS and WEPP Climate Assessment Tools (CAT): Case ...

    EPA Pesticide Factsheets

    This draft report supports application of two recently developed water modeling tools, the BASINS and WEPP climate assessment tools. The report presents a series of short case studies designed to illustrate the capabilities of these tools for conducting scenario based assessments of the potential future effects of climate change on water resources. This report presents a series of short, illustrative case studies using the BASINS and WEPP climate assessment tools.

  8. Heterogeneity in application, design, and analysis characteristics was found for controlled before-after and interrupted time series studies included in Cochrane reviews.

    PubMed

    Polus, Stephanie; Pieper, Dawid; Burns, Jacob; Fretheim, Atle; Ramsay, Craig; Higgins, Julian P T; Mathes, Tim; Pfadenhauer, Lisa M; Rehfuess, Eva A

    2017-11-01

    The aim of the study was to examine the application, design, and analysis characteristics of controlled before-after (CBA) and interrupted time series (ITS) studies and their use in Cochrane reviews. We searched the Cochrane library for reviews including these study designs from May 2012 to March 2015 and purposively selected, where available, two reviews each across 10 prespecified intervention types. We randomly selected two CBA and two ITS studies from each review. Two researchers independently extracted information from the studies and the respective reviews. Sixty-nine reviews considered CBA and ITS studies for inclusion. We analyzed 21 CBA and 16 ITS studies from 11 to 8 reviews, respectively. Cochrane reviews inconsistently defined and labeled CBA and ITS studies. Many studies did not meet the Cochrane definition or the minimum criteria provided by Cochrane Effective Practice and Organisation of Care. The studies present a heterogeneous set of study features and applied a large variety of analyses. While CBA and ITS studies represent important study designs to evaluate the effects of interventions, especially on a population or organizational level, unclear study design features challenge unequivocal classification and appropriate use. We discuss options for more specific definitions and explicit criteria for CBA and ITS studies. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Precision of Curriculum-Based Measurement Reading Data: Considerations for Multiple-Baseline Designs

    ERIC Educational Resources Information Center

    Klingbeil, David A.; Van Norman, Ethan R.; Nelson, Peter M.

    2017-01-01

    Single-case designs provide an established technology for evaluating the effects of academic interventions. Researchers interested in studying the long-term effects of reading interventions often use curriculum-based measures of reading (CBM-R) as they possess many of the desirable characteristics for use in a time-series design. The reliability…

  10. Assessing the Effectiveness of a Computer Simulation for Teaching Ecological Experimental Design

    ERIC Educational Resources Information Center

    Stafford, Richard; Goodenough, Anne E.; Davies, Mark S.

    2010-01-01

    Designing manipulative ecological experiments is a complex and time-consuming process that is problematic to teach in traditional undergraduate classes. This study investigates the effectiveness of using a computer simulation--the Virtual Rocky Shore (VRS)--to facilitate rapid, student-centred learning of experimental design. We gave a series of…

  11. Designing and Validating a Measure of Teacher Knowledge of Universal Design for Assessment (UDA)

    ERIC Educational Resources Information Center

    Jamgochian, Elisa Megan

    2010-01-01

    The primary purpose of this study was to design and validate a measure of teacher knowledge of Universal Design for Assessment (TK-UDA). Guided by a validity framework, a number of inferences, assumptions, and evidences supported this investigation. By addressing a series of research questions, evidence was garnered for the use of the measure to…

  12. Bias correction of risk estimates in vaccine safety studies with rare adverse events using a self-controlled case series design.

    PubMed

    Zeng, Chan; Newcomer, Sophia R; Glanz, Jason M; Shoup, Jo Ann; Daley, Matthew F; Hambidge, Simon J; Xu, Stanley

    2013-12-15

    The self-controlled case series (SCCS) method is often used to examine the temporal association between vaccination and adverse events using only data from patients who experienced such events. Conditional Poisson regression models are used to estimate incidence rate ratios, and these models perform well with large or medium-sized case samples. However, in some vaccine safety studies, the adverse events studied are rare and the maximum likelihood estimates may be biased. Several bias correction methods have been examined in case-control studies using conditional logistic regression, but none of these methods have been evaluated in studies using the SCCS design. In this study, we used simulations to evaluate 2 bias correction approaches-the Firth penalized maximum likelihood method and Cordeiro and McCullagh's bias reduction after maximum likelihood estimation-with small sample sizes in studies using the SCCS design. The simulations showed that the bias under the SCCS design with a small number of cases can be large and is also sensitive to a short risk period. The Firth correction method provides finite and less biased estimates than the maximum likelihood method and Cordeiro and McCullagh's method. However, limitations still exist when the risk period in the SCCS design is short relative to the entire observation period.

  13. Design-of-experiments to Reduce Life-cycle Costs in Combat Aircraft Inlets

    NASA Technical Reports Server (NTRS)

    Anderson, Bernhard H.; Baust, Henry D.; Agrell, Johan

    2003-01-01

    It is the purpose of this study to demonstrate the viability and economy of Design- of-Experiments (DOE), to arrive at micro-secondary flow control installation designs that achieve optimal inlet performance for different mission strategies. These statistical design concepts were used to investigate the properties of "low unit strength" micro-effector installation. "Low unit strength" micro-effectors are micro-vanes, set a very low angle-of incidence, with very long chord lengths. They are designed to influence the neat wall inlet flow over an extended streamwise distance. In this study, however, the long chord lengths were replicated by a series of short chord length effectors arranged in series over multiple bands of effectors. In order to properly evaluate the performance differences between the single band extended chord length installation designs and the segmented multiband short chord length designs, both sets of installations must be optimal. Critical to achieving optimal micro-secondary flow control installation designs is the understanding of the factor interactions that occur between the multiple bands of micro-scale vane effectors. These factor interactions are best understood and brought together in an optimal manner through a structured DOE process, or more specifically Response Surface Methods (RSM).

  14. Design Specification Issues in Time-Series Intervention Models.

    ERIC Educational Resources Information Center

    Huitema, Bradley E.; McKean, Joseph W.

    2000-01-01

    Presents examples of egregious errors of interpretation in time-series intervention models and makes recommendations regarding the correct specification of the design matrix. Discusses the profound effects of variants of the slope change variable in the design matrix. (SLD)

  15. Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: time-series and time-stratified case-crossover analyses with threshold effects.

    PubMed

    Li, Shi; Batterman, Stuart; Wasilevich, Elizabeth; Wahl, Robert; Wirth, Julie; Su, Feng-Chiao; Mukherjee, Bhramar

    2011-11-01

    Asthma morbidity has been associated with ambient air pollutants in time-series and case-crossover studies. In such study designs, threshold effects of air pollutants on asthma outcomes have been relatively unexplored, which are of potential interest for exploring concentration-response relationships. This study analyzes daily data on the asthma morbidity experienced by the pediatric Medicaid population (ages 2-18 years) of Detroit, Michigan and concentrations of pollutants fine particles (PM2.5), CO, NO2 and SO2 for the 2004-2006 period, using both time-series and case-crossover designs. We use a simple, testable and readily implementable profile likelihood-based approach to estimate threshold parameters in both designs. Evidence of significant increases in daily acute asthma events was found for SO2 and PM2.5, and a significant threshold effect was estimated for PM2.5 at 13 and 11 μg m(-3) using generalized additive models and conditional logistic regression models, respectively. Stronger effect sizes above the threshold were typically noted compared to standard linear relationship, e.g., in the time series analysis, an interquartile range increase (9.2 μg m(-3)) in PM2.5 (5-day-moving average) had a risk ratio of 1.030 (95% CI: 1.001, 1.061) in the generalized additive models, and 1.066 (95% CI: 1.031, 1.102) in the threshold generalized additive models. The corresponding estimates for the case-crossover design were 1.039 (95% CI: 1.013, 1.066) in the conditional logistic regression, and 1.054 (95% CI: 1.023, 1.086) in the threshold conditional logistic regression. This study indicates that the associations of SO2 and PM2.5 concentrations with asthma emergency department visits and hospitalizations, as well as the estimated PM2.5 threshold were fairly consistent across time-series and case-crossover analyses, and suggests that effect estimates based on linear models (without thresholds) may underestimate the true risk. Copyright © 2011 Elsevier Inc. All rights reserved.

  16. The Effects of STI Education on Korean Adolescents Using Smartphone Applications

    ERIC Educational Resources Information Center

    Jeong, Sookyung; Cha, Chiyoung; Lee, Jacob

    2017-01-01

    Objective: This study aimed to compare the effectiveness of adolescents' use of smartphone applications and educational booklets in an educational programme about sexually transmitted infections (STIs). Design: Non-equivalent control-group time-series design. Setting: The study was conducted in two public high schools located in two urban areas of…

  17. Using Cases in Higher Education: A Guide for Faculty and Administrators.

    ERIC Educational Resources Information Center

    Honan, James P.; Rule, Cheryl Sternman

    This resource is designed for faculty and administrators who use case studies to analyze, assess, and respond to the issues facing higher education leaders. It is especially designed to complement the series of casebooks of the Harvard Institutes for Higher Education. Following an introduction, Teaching and Learning with Case Studies, the chapters…

  18. Feasibility study of an Integrated Program for Aerospace-vehicle Design (IPAD) system. Volume 3: Engineering creative/evaluation processes, phase 1, task 2

    NASA Technical Reports Server (NTRS)

    Garrocq, C. A.; Hosek, J. J.

    1973-01-01

    A series of functional flow charts are considered that were developed to properly identify and record the degree of participation of the disciplines considered in this feasibility study and the type of data required in the design process.

  19. Design Criteria for Learning and Teaching Genetics

    ERIC Educational Resources Information Center

    Knippels, Marie-Christine P. J.; Waarlo, Arend Jan; Boersma, Kerst Th.

    2005-01-01

    While learning and teaching difficulties in genetics have been abundantly explored and described, there has been less focus on the development and field-testing of strategies to address them. To inform the design of such a strategy a review study, focus group interviews with teachers, a case study of a traditional series of genetics lessons,…

  20. Looking at Earth from space. Glossary of terms

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This glossary is one of a series of NASA publications designed to familiarize educators with global change issues and Mission to Planet Earth. The series enables teachers to enhance classroom studies with hands-on activities, including satellite images. Concepts and terms related to the global environment and the impact of human activities on the planet are presented.

  1. Alcohol and Other Chemicals. Adolescent Alcoholism: Recognizing, Intervening, and Treating Series No. 6.

    ERIC Educational Resources Information Center

    Gougelet, Robert M.; Nelson, E. Don

    This document is one of seven publications contained in a series of materials for physicians on recognizing, intervening with, and treating adolescent alcoholism. The materials in this unit of study are designed to help the physician know the different classes of drugs, recognize common presenting symptoms of drug overdose, and place use and abuse…

  2. Genesis lunar outpost: An evolutionary lunar habitat

    NASA Technical Reports Server (NTRS)

    Moore, Gary T. (Compiler); Baschiera, Dino; Fieber, Joe; Moths, Janis

    1990-01-01

    Students at the University of Wisconsin-Milwaukee Department of Agriculture undertook a series of studies of lunar habitats during the 1989 to 1990 academic year. Undergraduate students from architecture and mechanical and structural engineering with backgrounds in interior design, biology and construction technology were involved in a seminar in the fall semester followed by a design studio in the spring. The studies resulted in three design alternatives for lunar habitation and an integrated design for an early stage lunar outpost.

  3. Investigation of a Systematic Group of NACA 1-Series Cowlings with and Without Spinners

    NASA Technical Reports Server (NTRS)

    Nichols, Mark R; Keith, Arvid L , Jr

    1949-01-01

    Report presents the results of an investigation conducted in the Langley propeller research tunnel to study cowling-spinner combinations based on the NACA 1-series nose inlets and to obtain systematic design data for one family of approximately ellipsoidal spinners. In the main part of the investigation, 11 of the related spinners were tested in various combinations with 9 NACA open-nose cowlings, which were also tested without spinners. The effects of location and shape of the spinner, shape of the inner surface of the cowling lip, and operation of a propeller having approximately oval shanks were investigated briefly. In addition, a study was conducted to determine the correct procedure for extrapolating design conditions determined from the low-speed test data to the design conditions at the actual flight Mach number.

  4. Clean Cities case study : Barwood Cab Fleet study summary

    DOT National Transportation Integrated Search

    1999-05-21

    Barwood Cab Fleet Study Summary is the second in a new series called 'Alternative Fuel Information Case Studies', designed to present real-world experiences with alternative fuels to fleet managers and other industry stakeholders.

  5. Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship-Quasi-Experimental Designs.

    PubMed

    Schweizer, Marin L; Braun, Barbara I; Milstone, Aaron M

    2016-10-01

    Quasi-experimental studies evaluate the association between an intervention and an outcome using experiments in which the intervention is not randomly assigned. Quasi-experimental studies are often used to evaluate rapid responses to outbreaks or other patient safety problems requiring prompt, nonrandomized interventions. Quasi-experimental studies can be categorized into 3 major types: interrupted time-series designs, designs with control groups, and designs without control groups. This methods paper highlights key considerations for quasi-experimental studies in healthcare epidemiology and antimicrobial stewardship, including study design and analytic approaches to avoid selection bias and other common pitfalls of quasi-experimental studies. Infect Control Hosp Epidemiol 2016;1-6.

  6. Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship – Quasi-Experimental Designs

    PubMed Central

    Schweizer, Marin L.; Braun, Barbara I.; Milstone, Aaron M.

    2016-01-01

    Quasi-experimental studies evaluate the association between an intervention and an outcome using experiments in which the intervention is not randomly assigned. Quasi-experimental studies are often used to evaluate rapid responses to outbreaks or other patient safety problems requiring prompt non-randomized interventions. Quasi-experimental studies can be categorized into three major types: interrupted time series designs, designs with control groups, and designs without control groups. This methods paper highlights key considerations for quasi-experimental studies in healthcare epidemiology and antimicrobial stewardship including study design and analytic approaches to avoid selection bias and other common pitfalls of quasi-experimental studies. PMID:27267457

  7. Factors Associated with Evidence-Based Clinical Questions Presented in a Vertically Integrated Seminar Series at a U.S. Dental School.

    PubMed

    Shenoy, Gayathri M; Dragan, Irina F; Pagni, Sarah; Murphy, Jennipher; Karimbux, Nadeem

    2018-06-01

    The Basic Science/Clinical Science Spiral Seminar Series (BaSiCSsss) was implemented at Tufts University School of Dental Medicine in 2013. In the series, teams of dental students from all four years presented components of a clinical case, supported by evidence-based dentistry concepts. The role of the third-year student on each team was to present questions based on the PICO (Population, Intervention, Comparison, Outcome) method to support the treatment plan for the selected case. The primary aim of this study was to identify the dental discipline from which the PICO question was chosen, and the secondary aim was to review the level of evidence (journal impact factor, study design, and year of publication) of sources used to support the PICO questions. Presentations compiled during the 2014-15 and 2015-16 academic years were reviewed. The PICO questions and additional details from the publications used as reference (choice of journal, year of publication, study design) were reviewed. A total of 224 presentations were reviewed. The results showed that most topics were from the subjects of periodontology and prosthodontics. Systematic reviews and cohort studies were the most often used types of study design. The majority of the articles cited were recently published. The students used supporting references for the clinical questions published recently with a high level of evidence.

  8. Improving the conspicuity of trailblazing signs for incident management.

    DOT National Transportation Integrated Search

    1998-03-01

    This report represents efforts to design and evaluate a new sign design for emergency route trailblazing in a two-part series. : Study was an off-road field experiment conducted to determine the best sign color combination, letter stroke width, and l...

  9. FACTORS INFLUENCING THE DESIGN OF BIOACCUMULATION FACTOR AND BIOTA-SEDIMENT ACCUMULATION FACTOR FIELD STUDIES

    EPA Science Inventory

    A series of modeling simulations were performed to develop an understanding of the underlying factors and principles involved in developing field sampling designs for measuring bioaccumulation factors (BAFs) and biota-sediment accumulation factors (BSAFs. These simulations reveal...

  10. Energy in Our Society.

    ERIC Educational Resources Information Center

    Philadelphia Electric Co., PA. Energy Education Advisory Council.

    This publication is a series of 13 original classroom instructional packets and an additional 4 units adapted from National Science Teachers Association units. Each packet is designed to supplement specific existing subject curricula. Units have been designed for physics, chemistry, English, mathematics, general science and studies. Packets…

  11. The Timeseries Toolbox - A Web Application to Enable Accessible, Reproducible Time Series Analysis

    NASA Astrophysics Data System (ADS)

    Veatch, W.; Friedman, D.; Baker, B.; Mueller, C.

    2017-12-01

    The vast majority of data analyzed by climate researchers are repeated observations of physical process or time series data. This data lends itself of a common set of statistical techniques and models designed to determine trends and variability (e.g., seasonality) of these repeated observations. Often, these same techniques and models can be applied to a wide variety of different time series data. The Timeseries Toolbox is a web application designed to standardize and streamline these common approaches to time series analysis and modeling with particular attention to hydrologic time series used in climate preparedness and resilience planning and design by the U. S. Army Corps of Engineers. The application performs much of the pre-processing of time series data necessary for more complex techniques (e.g. interpolation, aggregation). With this tool, users can upload any dataset that conforms to a standard template and immediately begin applying these techniques to analyze their time series data.

  12. 77 FR 50469 - Notice of Public Workshop: “Designing for Impact III: Workshop on Building the National Network...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... series of public workshops entitled ``Designing for Impact: Workshop on Building the National Network for...-president-manufacturing-and-economy . The Designing for Impact workshop series is organized by the federal...: ``Designing for Impact III: Workshop on Building the National Network for Manufacturing Innovation'' AGENCY...

  13. 77 FR 19148 - Special Conditions: Airbus, A350-900 Series Airplane; Crew Rest Compartments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ...-900 series airplanes. These airplanes will have novel or unusual design features associated with two... standards for this design feature. These proposed special conditions contain the additional safety standards... for FAA type certification to June 28, 2009. The A350-900 series has a conventional layout with twin...

  14. 76 FR 62431 - Notice of Issuance of Final Determination Concerning Certain Ethernet Switches

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... importing 7 Series Ethernet switches assembled in China. The switches are designed to interconnect servers... country of origin of Arista's 7048, 7050, 7100, 7124, and 7500 series (``7 Series'') local area network..., packaged, and prepared for shipping. Arista's EOS TM (Extensible Operating System) software is designed to...

  15. Preparing Instructional Designers for Game-Based Learning: Part III. Game Design as a Collaborative Process

    ERIC Educational Resources Information Center

    Hirumi, Atsusi; Appelman, Bob; Rieber, Lloyd; Van Eck, Richard

    2010-01-01

    In this three part series, four professors who teach graduate level courses on the design of instructional video games discuss their perspectives on preparing instructional designers to optimize game-based learning. Part I set the context for the series and one of four panelists discussed what he believes instructional designers should know about…

  16. Quasi-experimental Studies in the Fields of Infection Control and Antibiotic Resistance, Ten Years Later: A Systematic Review.

    PubMed

    Alsaggaf, Rotana; O'Hara, Lyndsay M; Stafford, Kristen A; Leekha, Surbhi; Harris, Anthony D

    2018-02-01

    OBJECTIVE A systematic review of quasi-experimental studies in the field of infectious diseases was published in 2005. The aim of this study was to assess improvements in the design and reporting of quasi-experiments 10 years after the initial review. We also aimed to report the statistical methods used to analyze quasi-experimental data. DESIGN Systematic review of articles published from January 1, 2013, to December 31, 2014, in 4 major infectious disease journals. METHODS Quasi-experimental studies focused on infection control and antibiotic resistance were identified and classified based on 4 criteria: (1) type of quasi-experimental design used, (2) justification of the use of the design, (3) use of correct nomenclature to describe the design, and (4) statistical methods used. RESULTS Of 2,600 articles, 173 (7%) featured a quasi-experimental design, compared to 73 of 2,320 articles (3%) in the previous review (P<.01). Moreover, 21 articles (12%) utilized a study design with a control group; 6 (3.5%) justified the use of a quasi-experimental design; and 68 (39%) identified their design using the correct nomenclature. In addition, 2-group statistical tests were used in 75 studies (43%); 58 studies (34%) used standard regression analysis; 18 (10%) used segmented regression analysis; 7 (4%) used standard time-series analysis; 5 (3%) used segmented time-series analysis; and 10 (6%) did not utilize statistical methods for comparisons. CONCLUSIONS While some progress occurred over the decade, it is crucial to continue improving the design and reporting of quasi-experimental studies in the fields of infection control and antibiotic resistance to better evaluate the effectiveness of important interventions. Infect Control Hosp Epidemiol 2018;39:170-176.

  17. Graphical Data Analysis on the Circle: Wrap-Around Time Series Plots for (Interrupted) Time Series Designs.

    PubMed

    Rodgers, Joseph Lee; Beasley, William Howard; Schuelke, Matthew

    2014-01-01

    Many data structures, particularly time series data, are naturally seasonal, cyclical, or otherwise circular. Past graphical methods for time series have focused on linear plots. In this article, we move graphical analysis onto the circle. We focus on 2 particular methods, one old and one new. Rose diagrams are circular histograms and can be produced in several different forms using the RRose software system. In addition, we propose, develop, illustrate, and provide software support for a new circular graphical method, called Wrap-Around Time Series Plots (WATS Plots), which is a graphical method useful to support time series analyses in general but in particular in relation to interrupted time series designs. We illustrate the use of WATS Plots with an interrupted time series design evaluating the effect of the Oklahoma City bombing on birthrates in Oklahoma County during the 10 years surrounding the bombing of the Murrah Building in Oklahoma City. We compare WATS Plots with linear time series representations and overlay them with smoothing and error bands. Each method is shown to have advantages in relation to the other; in our example, the WATS Plots more clearly show the existence and effect size of the fertility differential.

  18. Nonlinear time-series-based adaptive control applications

    NASA Technical Reports Server (NTRS)

    Mohler, R. R.; Rajkumar, V.; Zakrzewski, R. R.

    1991-01-01

    A control design methodology based on a nonlinear time-series reference model is presented. It is indicated by highly nonlinear simulations that such designs successfully stabilize troublesome aircraft maneuvers undergoing large changes in angle of attack as well as large electric power transients due to line faults. In both applications, the nonlinear controller was significantly better than the corresponding linear adaptive controller. For the electric power network, a flexible AC transmission system with series capacitor power feedback control is studied. A bilinear autoregressive moving average reference model is identified from system data, and the feedback control is manipulated according to a desired reference state. The control is optimized according to a predictive one-step quadratic performance index. A similar algorithm is derived for control of rapid changes in aircraft angle of attack over a normally unstable flight regime. In the latter case, however, a generalization of a bilinear time-series model reference includes quadratic and cubic terms in angle of attack.

  19. Investigation of a catalytic gas generator for the Space Shuttle APU. [hydrazine Auxiliary Propulsion Unit

    NASA Technical Reports Server (NTRS)

    Emmons, D. L.; Huxtable, D. D.; Blevins, D. R.

    1974-01-01

    An investigation was conducted to establish the capability of a monopropellant hydrazine catalytic gas generator to meet the requirements specified for the Space Shuttle APU. Detailed analytical and experimental studies were conducted on potential problem areas including long-term nitriding effects on materials, design variables affecting catalyst life, vehicle vibration effects, and catalyst oxidation/contamination. A full-scale gas generator, designed to operate at a chamber pressure of 750 psia and a flow rate of 0.36 lbm/sec, was fabricated and subjected to three separate life test series. The objective of the first test series was to demonstrate the capability of the gas generator to successfully complete 20 simulated Space Shuttle missions in steady-state operation. The gas generator was then refurbished and subjected to a second series of tests to demonstrate the pulse-mode capability of the gas generator during 20 simulated missions. The third series of tests was conducted with a refurbished reactor to further demonstrate pulse-mode capability with a modified catalyst bed.

  20. Simulation-based power calculation for designing interrupted time series analyses of health policy interventions.

    PubMed

    Zhang, Fang; Wagner, Anita K; Ross-Degnan, Dennis

    2011-11-01

    Interrupted time series is a strong quasi-experimental research design to evaluate the impacts of health policy interventions. Using simulation methods, we estimated the power requirements for interrupted time series studies under various scenarios. Simulations were conducted to estimate the power of segmented autoregressive (AR) error models when autocorrelation ranged from -0.9 to 0.9 and effect size was 0.5, 1.0, and 2.0, investigating balanced and unbalanced numbers of time periods before and after an intervention. Simple scenarios of autoregressive conditional heteroskedasticity (ARCH) models were also explored. For AR models, power increased when sample size or effect size increased, and tended to decrease when autocorrelation increased. Compared with a balanced number of study periods before and after an intervention, designs with unbalanced numbers of periods had less power, although that was not the case for ARCH models. The power to detect effect size 1.0 appeared to be reasonable for many practical applications with a moderate or large number of time points in the study equally divided around the intervention. Investigators should be cautious when the expected effect size is small or the number of time points is small. We recommend conducting various simulations before investigation. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. The Missing Treatment Design Element: Continuity of Treatment When Multiple Postobservations Are Used in Time-Series and Repeated Measures Study Designs

    ERIC Educational Resources Information Center

    Barnette, J. Jackson; Wallis, Anne Baber

    2005-01-01

    We rely a great deal on the schematic descriptions that represent experimental and quasi-experimental design arrangements, as well as the discussions of threats to validity associated with these, provided by Campbell and his associates: Stanley, Cook, and Shadish. Some of these designs include descriptions of treatments removed, removed and then…

  2. MECHANICAL TECHNOLOGY, DESIGN AND PRODUCTION, SUGGESTED TECHNIQUES FOR DETERMINING COURSES OF STUDY IN VOCATIONAL EDUCATION PROGRAMS.

    ERIC Educational Resources Information Center

    PETERSON, CLARENCE E.

    THIS PUBLICATION IS THE THIRD IN A SERIES DESIGNED TO PROVIDE INFORMATION TO HELP STATES ORGANIZE AND OPERATE PROGRAMS UNDER TITLE VIII OF THE NATIONAL DEFENSE EDUCATION ACT OF 1958. THE OTHER PUBLICATIONS ARE "MECHANICAL DRAFTING AND DESIGN TECHNOLOGY" (VT 001 823) AND "ELECTRICAL AND ELECTRONIC TECHNOLOGY" (VT 002 421). EACH…

  3. Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5- a ]pyrazines as ATR Inhibitors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barsanti, Paul A.; Aversa, Robert J.; Jin, Xianming

    A saturation strategy focused on improving the selectivity and physicochemical properties of ATR inhibitor HTS hit 1 led to a novel series of highly potent and selective tetrahydropyrazolo[1,5-a]pyrazines. Use of PI3Kα mutants as ATR crystal structure surrogates was instrumental in providing cocrystal structures to guide the medicinal chemistry designs. Detailed DMPK studies involving cyanide and GSH as trapping agents during microsomal incubations, in addition to deuterium-labeled compounds as mechanistic probes uncovered the molecular basis for the observed CYP3A4 TDI in the series.

  4. Community design and the incidence of crashes involving pedestrians and motorists aged 75 and older.

    DOT National Transportation Integrated Search

    2012-04-01

    Contemporary community design practice has focused on strategies intended to make communities safe for families with children. Comparatively little attention has been given to its effects on older adults. This study employs a series of negative binom...

  5. Development of guidelines for incorporation of vertical ground motion effects in seismic design of highway bridges.

    DOT National Transportation Integrated Search

    2008-05-01

    This study was undertaken with the objective of assessing the current provisions in SDC-2006 for incorporating : vertical effects of ground motions in seismic evaluation and design of ordinary highway bridges. A : comprehensive series of simulations ...

  6. Case Designs for Ill-Structured Problems: Analysis and Implications for Practice

    ERIC Educational Resources Information Center

    Dabbagh, Nada; Blijd, Cecily Williams

    2009-01-01

    This study is a third in a series of studies that examined students' information seeking and problem solving behaviors while interacting with one of two types of web-based representations of an ill-structured instructional design case: hierarchical (tree-like) and heterarchical (network-like). A Java program was used to track students' hypermedia…

  7. Large-scale breeder reactor prototype mechanical pump conceptual design study, hot leg

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1976-09-01

    Due to the extensive nature of this study, the report is presented as a series of small reports. The complete design analysis is placed in a separate section. The drawings and tabulations are in the back portion of the report. Other topics are enumerated and located as shown in the table of contents.

  8. Women's Studies. Developments in Classroom Instruction Series.

    ERIC Educational Resources Information Center

    McLure, Gail Thomas; McLure, John W.

    This book is designed to help educators design and plan curriculum on women's studies. It focuses on the curriculum changes needed to eliminate sex role stereotypes and presents a new model for achieving psychological androgyny--a climate in which men and women will be able to develop freely without the inhibitions and constraints of sex roles.…

  9. Radiology/Imaging. Clinical Rotation. Instructor's Packet and Student Study Packet.

    ERIC Educational Resources Information Center

    Texas Univ., Austin. Extension Instruction and Materials Center.

    The instructor's packet, the first of two packets, is one of a series of materials designed to help students who are investigating the activities within a radiology department or considering any of the imaging technologies as a career. The material is designed to relate training experience to information studied in the classroom. This packet…

  10. Stewpot Pre-School Feasibility Study. Daycare Planning Guidelines: A Pre-School for Stewpot Community Services.

    ERIC Educational Resources Information Center

    Jacob, Paul; Poros, John

    The Education Design Institute developed a series of tearsheets that were used as part of a feasibility study for a pre-school. The tearsheets, which aid designers in planning pre-school environments, outline educational objectives; optimum square foot standards; general environmental concerns; and furniture and equipment for infant, toddler, and…

  11. Forest, Land, and Water: Understanding Our Natural Resources. Natural Resources Education Series.

    ERIC Educational Resources Information Center

    Sunal, Dennis; And Others

    This curriculum consists of a Teacher's Guide and a series of 12 instructional modules, that are centered around concepts important in the study of national resource science. The modules are designed to supplement textbooks with activities for students in primary and middle grades (K-8). The titles of the modules are: (1) Natural History of a…

  12. Strategic Financial Management for Conferences, Workshops, and Meetings. Jossey-Bass Higher and Adult Education Series and Jossey-Bass Management Series.

    ERIC Educational Resources Information Center

    Simerly, Robert G.

    This book shows how to design and implement a strategic financial management system for any organization that plans conferences, workshops, and meetings. It guides the reader through steps in the budgeting and strategic financial management process. Case studies, hints, and guidelines for avoiding the most common mistakes are given, and…

  13. The Civil War: Slavery and the Crisis of Union. Public Issues Series.

    ERIC Educational Resources Information Center

    Singleton, Laurel R., Ed.

    This booklet is part of a series of units designed to help students take and defend a position on public issues. The unit presented here explores questions about when people should challenge authority through a study of the Civil War and slavery. The booklet is divided into six sections. The first and last are an introduction and review…

  14. THE SOUNDS OF ENGLISH AND ITALIAN, A SYSTEMATIC ANALYSIS OF THE CONTRASTS BETWEEN THE SOUND SYSTEMS. CONTRASTIVE STRUCTURE SERIES.

    ERIC Educational Resources Information Center

    AGARD, FREDERICK B.; DI PIETRO, ROBERT J.

    DESIGNED AS A SOURCE OF INFORMATION FOR PROFESSIONALS PREPARING INSTRUCTIONAL MATERIALS, PLANNING COURSES, OR DEVELOPING CLASSROOM TECHNIQUES FOR FOREIGN LANGUAGE PROGRAMS, A SERIES OF STUDIES HAS BEEN PREPARED THAT CONTRASTS, IN TWO VOLUMES FOR EACH OF THE FIVE MOST COMMONLY TAUGHT FOREIGN LANGUAGES IN THE UNITED STATES, THE SOUND AND GRAMMATICAL…

  15. Three-in-One Resonance Tube for Harmonic Series Sound Wave Experiments

    ERIC Educational Resources Information Center

    Jaafar, Rosly; Nazihah Mat Daud, Anis; Ali, Shaharudin; Kadri Ayop, Shahrul

    2017-01-01

    In this study we constructed a special three-in-one resonance tube for a harmonic series sound waves experiment. It is designed for three different experiments: both-open-end, one-closed-end and both-closed-end tubes. The resonance tube consists of a PVC conduit with a rectangular hole, rubber tube, plastic stopper with an embedded microphone and…

  16. Evaluation of 6-chloro-N-[3,4-disubstituted-1,3-thiazol-2(3H)-ylidene]-1,3-benzothiazol-2-amine Using Drug Design Concept for Their Targeted Activity Against Colon Cancer Cell Lines HCT-116, HCT15, and HT29.

    PubMed

    Zhu, Ming-Li; Wang, Cui-Yue; Xu, Cheng-Mian; Bi, Wei-Ping; ZHou, Xiu-Ying

    2017-03-05

    BACKGROUND Colorectal adenocarcinoma is the second leading cause of cancer-related death in the world. The stage of the disease is related to the survival of the patient, and in early phases surgery is the main modality of treatment. The main aim of modern medicinal chemistry is to synthesize small molecules via drug designing, especially by targeting tumor cells. MATERIAL AND METHODS A new series of 19 compounds containing benzothiazole and thiazole were designed. Molecular docking studies were performed on the designed series of molecules. Compounds showing good binding affinity towards the EGFR receptor were selected for synthetic studies. Characterization of the synthesized compounds was done by FTIR, 1HNMR, Mass and C, H, N, analysis. RESULTS The anticancer evaluation of the synthesized compounds was done at NIC, USA at a single dose against colon cancer cell lines HCT 116, HCT15, and HC 29. The active compounds were further evaluated for the 5-dose testing. Compounds were designed by using docking analysis. To ascertain the interaction of EGFR tyrosine kinase binding, energy calculation was used. CONCLUSIONS The results of the present study indicate that the designed compounds show good activity against colon cancer cell lines, which may be further studied to design new potential molecules.

  17. Effect of Impact Damage and Open Hole on Compressive Strength of Hybrid Composite Laminates

    NASA Technical Reports Server (NTRS)

    Hiel, Clement; Brinson, H. F.

    1993-01-01

    Impact damage tolerance is a frequently listed design requirement for composites hardware. The effect of impact damage and open hole size on laminate compressive strength was studied on sandwich beam specimens which combine CFRP-GFRP hybrid skins and a syntactic foam core. Three test specimen configurations have been investigated for this study. The first two were sandwich beams which were loaded in pure bending (by four point flexure). One series had a skin damaged by impact, and the second series had a circular hole machined through one of the skins. The reduction of compressive strength with increasing damage (hole) size was compared. Additionally a third series of uniaxially loaded open hole compression coupons were tested to generate baseline data for comparison with both series of sandwich beams.

  18. Design of static synchronous series compensator based damping controller employing invasive weed optimization algorithm.

    PubMed

    Ahmed, Ashik; Al-Amin, Rasheduzzaman; Amin, Ruhul

    2014-01-01

    This paper proposes designing of Static Synchronous Series Compensator (SSSC) based damping controller to enhance the stability of a Single Machine Infinite Bus (SMIB) system by means of Invasive Weed Optimization (IWO) technique. Conventional PI controller is used as the SSSC damping controller which takes rotor speed deviation as the input. The damping controller parameters are tuned based on time integral of absolute error based cost function using IWO. Performance of IWO based controller is compared to that of Particle Swarm Optimization (PSO) based controller. Time domain based simulation results are presented and performance of the controllers under different loading conditions and fault scenarios is studied in order to illustrate the effectiveness of the IWO based design approach.

  19. Hazards Due to Overdischarge in Lithium-ion Cylindrical Cells in Multi-cell Configurations

    NASA Technical Reports Server (NTRS)

    Jeevarajan, Judith; Strangways, Brad; Nelson, Tim

    2010-01-01

    Lithium-ion cells in the cylindrical Commercial-off-the-shelf 18650 design format were used to study the hazards associated with overdischarge. The cells in series or in parallel configurations were subjected to different conditions of overdischarge. The cells in parallel configurations were all overdischarged to 2.0 V for 75 cycles with one cell removed at 25 cycles to study the health of the cell. The cells in series were designed to be in an unbalanced configuration by discharging one cell in each series configuration before the start of test. The discharge consisted of removing a pre-determined capacity from the cell. This ranged from 50 to 150 mAh removal. The cells were discharged down to a predetermined end-of-discharge voltage cutoff which allowed the cell with lower capacity to go into an overdischarge mode. The cell modules that survived the 75 cycles were subjected to one overvoltage test to 4.4 V/cell.

  20. 76 FR 41491 - Applications for New Awards; Arts in Education National Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-14

    ... the arts as a core academic subject in the school curriculum. Interrupted time series design means a... interrupted time series design that relies on the comparison of treatment effects on a single subject or group.... That is, the series should show an ``interruption'' of the prior situation at the time when the program...

  1. Does ought imply can?

    PubMed Central

    Kurthy, Miklos; Lawford-Smith, Holly; Sousa, Paulo

    2017-01-01

    Most philosophers believe that a person can have an obligation only insofar as she is able to fulfil it, a principle generally referred to as “Ought Implies Can”. Arguably, this principle reflects something basic about the ordinary concept of obligation. However, in a paper published recently in this journal, Wesley Buckwalter and John Turri presented evidence for the conclusion that ordinary people in fact reject that principle. With a series of studies, they claimed to have demonstrated that, in people’s judgements, obligations persist irrespective of whether those who hold them have the ability to fulfil them. We argue in this paper that due to some problems in their design, Buckwalter & Turri’s conclusions may not be warranted. We present the results of a series of studies demonstrating the problems with their design and showing that, with an improved design, people judge that obligation depends on ability after all. PMID:28403195

  2. 78 FR 69885 - AIM Growth Series (Invesco Growth Series), et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... designed to ensure that Sub-Advisors comply with a Subadvised Series' investment objective, policies and...] AIM Growth Series (Invesco Growth Series), et al.; Notice of Application November 15, 2013. AGENCY... approval and would grant relief from certain disclosure requirements. APPLICANTS: AIM Growth Series...

  3. Early detection network design and search strategy issues

    EPA Science Inventory

    We conducted a series of field and related modeling studies (2005-2012) to evaluate search strategies for Great Lakes coastal ecosystems that are at risk of invasion by non-native aquatic species. In developing a network, we should design to achieve an acceptable limit of detect...

  4. Rheumatoid Arthritis Educational Video Series

    MedlinePlus Videos and Cool Tools

    ... Corner / Patient Webcasts / Rheumatoid Arthritis Educational Video Series Rheumatoid Arthritis Educational Video Series This series of five videos was designed to help you learn more about Rheumatoid Arthritis (RA). You will learn how the diagnosis of ...

  5. Novel Design for Centrifugal Countercurrent Chromatography: II. Studies on Novel Geometries of Zigzag Toroidal Tubing

    PubMed Central

    Yang, Yi; Aisa, Haji Akber; Ito, Yoichiro

    2009-01-01

    The toroidal column using a zigzag pattern has been improved in both retention of the stationary phase and peak resolution. To further improve the retention of stationary phase and peak resolution, a series of novel geometric designs of tubing (plain, mid-clamping, flattened and flat-twisted tubing) was evaluated their performance in CCC. The results showed that the tubing which was flattened vertically against centrifugal force (vert-flattened tubing) produced the best peak resolution among them. Using vert-flattened tubing a series of experiments was performed to study the effects of column capacity and sample size. The results indicated that a 0.25 ml capacity column is ideal for analysis of small amount samples. PMID:20454530

  6. Bivariate analysis of floods in climate impact assessments.

    PubMed

    Brunner, Manuela Irene; Sikorska, Anna E; Seibert, Jan

    2018-03-01

    Climate impact studies regarding floods usually focus on peak discharges and a bivariate assessment of peak discharges and hydrograph volumes is not commonly included. A joint consideration of peak discharges and hydrograph volumes, however, is crucial when assessing flood risks for current and future climate conditions. Here, we present a methodology to develop synthetic design hydrographs for future climate conditions that jointly consider peak discharges and hydrograph volumes. First, change factors are derived based on a regional climate model and are applied to observed precipitation and temperature time series. Second, the modified time series are fed into a calibrated hydrological model to simulate runoff time series for future conditions. Third, these time series are used to construct synthetic design hydrographs. The bivariate flood frequency analysis used in the construction of synthetic design hydrographs takes into account the dependence between peak discharges and hydrograph volumes, and represents the shape of the hydrograph. The latter is modeled using a probability density function while the dependence between the design variables peak discharge and hydrograph volume is modeled using a copula. We applied this approach to a set of eight mountainous catchments in Switzerland to construct catchment-specific and season-specific design hydrographs for a control and three scenario climates. Our work demonstrates that projected climate changes have an impact not only on peak discharges but also on hydrograph volumes and on hydrograph shapes both at an annual and at a seasonal scale. These changes are not necessarily proportional which implies that climate impact assessments on future floods should consider more flood characteristics than just flood peaks. Copyright © 2017. Published by Elsevier B.V.

  7. Construct-a-Glove. Science by Design Series.

    ERIC Educational Resources Information Center

    Pulis, Lee

    This book is one of four books in the Science-by-Design Series created by TERC and funded by the National Science Foundation (NSF). It offers high school students a challenging, hands-on opportunity to compare the function and design of many types of handwear from a hockey mitt to a surgical glove, and design and test a glove to their own…

  8. 77 FR 64023 - Special Conditions: Airbus Model A318, A319, A320, and A321 Series Airplanes; Design Roll...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... airplanes with modification 160023 (Sharklet). These airplanes will have novel or unusual design features..., A320, and A321 series airplanes because of a novel or unusual design feature, special conditions are... model that incorporates the same novel or unusual design feature, or should any other model already...

  9. Design and Usability Assessment of a Dialogue-Based Cognitive Tutoring System to Model Expert Problem Solving in Research Design

    ERIC Educational Resources Information Center

    Hung, Wei-Chen; Smith, Thomas J.; Smith, M. Cecil

    2015-01-01

    Technology provides the means to create useful learning and practice environments for learners. Well-designed cognitive tutor systems, for example, can provide appropriate learning environments that feature cognitive supports (ie, scaffolding) for students to increase their procedural knowledge. The purpose of this study was to conduct a series of…

  10. The Monitoring the Future Project after Four Decades: Design and Procedures. Monitoring the Future Occasional Paper Series. Paper 82

    ERIC Educational Resources Information Center

    Bachman, Jerald G.; Johnston, Lloyd D.; O'Malley, Patrick M.; Schulenberg, John E.; Miech, Richard A.

    2015-01-01

    The purpose of this paper is to provide a detailed description of the Monitoring the Future research design, including sampling design, data collection procedures, measurement content, and questionnaire format. This study assesses the changing lifestyles, values, and preferences of American youth on a continuing basis. Each year since 1975, at…

  11. Out on a Limb. Personality Booklet 3. Teacher's Edition=En un aprieto. Personalidad libro 3. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  12. Conservation, Pollution. Environment Booklet 3. Teacher's Edition=Conservacion, contaminacion. Libro del medio ambiente 3. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  13. All about Sex: The School Counselor's Guide to Handling Tough Adolescent Problems. Practical Skills for Counselors Series.

    ERIC Educational Resources Information Center

    Bradley, Loretta J.; Jarchow, Elaine; Robinson, Beth

    This book is designed to be used by school counselors to help them respond to sexual issues of adolescence. Chapter 1, "Sexual Stuff: What's a Counselor To Do?" introduces the topic of knowing the boundaries of school policy, parents, values and religion, and confidentiality. A series of case studies are presented and answers common concerns…

  14. Setting Goals and Getting There: Planning Tomorrow Today. BANK-ED II: Personal Money Management Series.

    ERIC Educational Resources Information Center

    Butterfield, Sherri M.

    The three units in this guide are designed to teach language, mathematics, and social studies skills associated with earning and managing money to students in grades 7-9. Each unit includes notes to aid the teacher in preparing and presenting the material, pre/post tests, and a series of one-page reproducible sheets which contain information or…

  15. Projects That Matter: Concepts and Models for Service-Learning in Engineering. AAHE's Series on Service-Learning in the Disciplines.

    ERIC Educational Resources Information Center

    Tsang, Edmund, Ed.

    This volume, the 14th in a series of monographs on service learning and academic disciplinary areas, is designed as a practical guide for faculty seeking to integrate service learning into an engineering course. The volume also deals with larger issues in engineering education and provides case studies of service-learning courses. The articles…

  16. Urban Ecosystems. Environment Booklet 4. Teacher's Edition =Ecosist urbanos. Libro del medio ambiente 4. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and are designed to help students understand some major human problems and make sound, responsive decisions to…

  17. Life Support Systems. Environment Booklet 1. Teacher's Edition=Sistemas vitales. Libro del medio ambiente 1. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  18. Others and I. Personality Booklet 1. Teacher's Edition=Otros y Yo. Personalidad libro 1. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  19. Response-based Multimedia and the Culture of the Classroom: A Pilot Study of "Kid's Space" in Four Elementary Classrooms. Report Series 2.26.

    ERIC Educational Resources Information Center

    Meskill, Carla; Swan, Karen

    A pilot study describes the prototype design and classroom implementation of "Kid's Space," a response-based multimedia application for literature teaching and learning. "Kid's Space" was designed around the metaphor of a universe populated by the individual student's world. Each world supports a variety of personal spaces in…

  20. World War II Unit. Using Primary Sources in the Classroom.

    ERIC Educational Resources Information Center

    Alabama Dept. of Archives and History, Montgomery.

    This teaching unit, "World War II Unit," is the ninth in a series of 10 units about Alabama state history, part of a project designed to help teachers integrate the use of primary source materials into their classrooms. Although the units are designed to augment the study of Alabama, they are useful in the study of U.S. history, world…

  1. CVO driver fatigue and complex in-vehicle systems

    DOT National Transportation Integrated Search

    1997-10-01

    As one of a series of studies aimed at gathering data to develop human factors design guidelines for Advanced Traveler Information Systems (ATIS) and Commercial Vehicle Operations (CVO), the present study utilized a driving simulator to study CVO dri...

  2. The risk of acute liver injury among users of antibiotic medications: a comparison of case-only studies.

    PubMed

    Brauer, Ruth; Ruigómez, Ana; Klungel, Olaf; Reynolds, Robert; Feudjo Tepie, Maurille; Smeeth, Liam; Douglas, Ian

    2016-03-01

    The aims of this study were two-fold: (i) to investigate the effect of exposure to antibiotic agents on the risk of acute liver injury using a self-controlled case series and case-crossover study and (ii) to compare the results between the case-only studies. For the self-controlled case series study relative incidence ratios (IRR) were calculated by dividing the rate of acute liver injury experienced during patients' periods of exposure to antibiotics to patients' rate of events during non-exposed time using conditional Poisson regression. For the case-crossover analysis we calculated Odds Ratios (OR) using conditional logistic regression by comparing exposure during 14- and 30-day risk windows with exposure during control moments. Using the self-controlled case series approach, the IRR was highest during the first 7 days after receipt of a prescription (10.01, 95% CI 6.59-15.18). Omitting post-exposure washout periods lowered the IRR to 7.2. The highest estimate in the case-crossover analysis was found when two 30-day control periods 1 year prior to the 30-day ALI risk period were retained in the analysis: OR = 6.5 (95% CI, 3.95-10.71). The lowest estimate was found when exposure in the 14-day risk period was compared to exposure in four consecutive 14-day control periods immediately prior to the risk period (OR = 3.05, 95% CI, 2.06-4.53). An increased relative risk of acute liver injury was consistently observed using both self-controlled case series and case-crossover designs. Case-only designs can be used as a viable alternative study design to study the risk of acute liver injury, albeit with some limitations. © 2015 The Authors Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons Ltd.

  3. Quality assurance of road roughness measurement.

    DOT National Transportation Integrated Search

    2000-01-01

    This report describes a study designed to establish the accuracy and repeatability of high-speed, road-profiling equipment. This effort focused on a series of roughness validation sites. The study addresses selecting the appropriate sites, determinin...

  4. Reverse Commute Transportation: Emerging Provider Roles

    DOT National Transportation Integrated Search

    1992-03-01

    This study reports the findings of a small Federal Transit Administration funded study designed to identify and briefly evaluate both historical and modern reverse commute experiments and projects. A series of Federal and State programs funded revers...

  5. Birds. Nature Discovery I.

    ERIC Educational Resources Information Center

    Stone, Sally F.

    The birds of New England and their particular habitats are explored in this guide which is part of a series of Nature Discovery publications. The materials are designed to directly supplement the natural science curricula and to complement other subject areas including social studies, language arts, music, and art. The program is designed for…

  6. Estimating Slope and Level Change in N = 1 Designs

    ERIC Educational Resources Information Center

    Solanas, Antonio; Manolov, Rumen; Onghena, Patrick

    2010-01-01

    The current study proposes a new procedure for separately estimating slope change and level change between two adjacent phases in single-case designs. The procedure eliminates baseline trend from the whole data series before assessing treatment effectiveness. The steps necessary to obtain the estimates are presented in detail, explained, and…

  7. A Design Model of Distributed Scaffolding for Inquiry-Based Learning

    ERIC Educational Resources Information Center

    Hsu, Ying-Shao; Lai, Ting-Ling; Hsu, Wei-Hsiu

    2015-01-01

    This study presents a series of three experiments that focus on how distributed scaffolding influences learners' conceptual understanding and reasoning from combined levels of triangulation, at the interactive level (discourses within a focus group) and the collective level (class). Three inquiry lessons on plate tectonics (LPT) were designed,…

  8. Machinist (AFSC 42750).

    ERIC Educational Resources Information Center

    Air Univ., Gunter AFS, Ala. Extension Course Inst.

    This four-volume student text is designed for use by Air Force personnel enrolled in a self-study extension course for machinists. Covered in the individual volumes are machine shop fundamentals, metallurgy and advanced machine work, advanced machine work, and tool design and shop management. Each volume in the set contains a series of lessons,…

  9. Bayesian analysis of time-series data under case-crossover designs: posterior equivalence and inference.

    PubMed

    Li, Shi; Mukherjee, Bhramar; Batterman, Stuart; Ghosh, Malay

    2013-12-01

    Case-crossover designs are widely used to study short-term exposure effects on the risk of acute adverse health events. While the frequentist literature on this topic is vast, there is no Bayesian work in this general area. The contribution of this paper is twofold. First, the paper establishes Bayesian equivalence results that require characterization of the set of priors under which the posterior distributions of the risk ratio parameters based on a case-crossover and time-series analysis are identical. Second, the paper studies inferential issues under case-crossover designs in a Bayesian framework. Traditionally, a conditional logistic regression is used for inference on risk-ratio parameters in case-crossover studies. We consider instead a more general full likelihood-based approach which makes less restrictive assumptions on the risk functions. Formulation of a full likelihood leads to growth in the number of parameters proportional to the sample size. We propose a semi-parametric Bayesian approach using a Dirichlet process prior to handle the random nuisance parameters that appear in a full likelihood formulation. We carry out a simulation study to compare the Bayesian methods based on full and conditional likelihood with the standard frequentist approaches for case-crossover and time-series analysis. The proposed methods are illustrated through the Detroit Asthma Morbidity, Air Quality and Traffic study, which examines the association between acute asthma risk and ambient air pollutant concentrations. © 2013, The International Biometric Society.

  10. Use of Traditional and Novel Methods to Evaluate the Influence of an EVA Glove on Hand Performance

    NASA Technical Reports Server (NTRS)

    Benson, Elizabeth A.; England, Scott A.; Mesloh, Miranda; Thompson, Shelby; ajulu, Sudhakar

    2010-01-01

    The gloved hand is one of an astronaut s primary means of interacting with the environment, and any restrictions imposed by the glove can strongly affect performance during extravehicular activity (EVA). Glove restrictions have been the subject of study for decades, yet previous studies have generally been unsuccessful in quantifying glove mobility and tactility. Past studies have tended to focus on the dexterity, strength, and functional performance of the gloved hand; this provides only a circumspect analysis of the impact of each type of restriction on the glove s overall capability. The aim of this study was to develop novel capabilities to provide metrics for mobility and tactility that can be used to assess the performance of a glove in a way that could enable designers and engineers to improve their current designs. A series of evaluations were performed to compare unpressurized and pressurized (4.3 psi) gloved conditions with the ungloved condition. A second series of evaluations were performed with the Thermal Micrometeoroid Garment (TMG) removed. This series of tests provided interesting insight into how much of an effect the TMG has on gloved mobility - in some cases, the presence of the TMG restricted glove mobility as much as pressurization did. Previous hypotheses had assumed that the TMG would have a much lower impact on mobility, but these results suggest that an improvement in the design of the TMG could have a significant impact on glove performance. Tactility testing illustrated the effect of glove pressurization, provided insight into the design of hardware that interfaces with the glove, and highlighted areas of concern. The metrics developed in this study served to benchmark the Phase VI EVA glove and to develop requirements for the next-generation glove for the Constellation program.

  11. 78 FR 39023 - ING Investments, LLC, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... portion of a Sub- Advised Series' assets, and (c) implement procedures reasonably designed to ensure that..., ING Series Fund, Inc., ING Strategic Allocation Portfolios, Inc., ING Variable Funds, ING Variable... Investment Company may offer one or more series of shares (each a ``Series'' and collectively, ``Series...

  12. Information content of household-stratified epidemics.

    PubMed

    Kinyanjui, T M; Pellis, L; House, T

    2016-09-01

    Household structure is a key driver of many infectious diseases, as well as a natural target for interventions such as vaccination programs. Many theoretical and conceptual advances on household-stratified epidemic models are relatively recent, but have successfully managed to increase the applicability of such models to practical problems. To be of maximum realism and hence benefit, they require parameterisation from epidemiological data, and while household-stratified final size data has been the traditional source, increasingly time-series infection data from households are becoming available. This paper is concerned with the design of studies aimed at collecting time-series epidemic data in order to maximize the amount of information available to calibrate household models. A design decision involves a trade-off between the number of households to enrol and the sampling frequency. Two commonly used epidemiological study designs are considered: cross-sectional, where different households are sampled at every time point, and cohort, where the same households are followed over the course of the study period. The search for an optimal design uses Bayesian computationally intensive methods to explore the joint parameter-design space combined with the Shannon entropy of the posteriors to estimate the amount of information in each design. For the cross-sectional design, the amount of information increases with the sampling intensity, i.e., the designs with the highest number of time points have the most information. On the other hand, the cohort design often exhibits a trade-off between the number of households sampled and the intensity of follow-up. Our results broadly support the choices made in existing epidemiological data collection studies. Prospective problem-specific use of our computational methods can bring significant benefits in guiding future study designs. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  13. Models for forecasting hospital bed requirements in the acute sector.

    PubMed Central

    Farmer, R D; Emami, J

    1990-01-01

    STUDY OBJECTIVE--The aim was to evaluate the current approach to forecasting hospital bed requirements. DESIGN--The study was a time series and regression analysis. The time series for mean duration of stay for general surgery in the age group 15-44 years (1969-1982) was used in the evaluation of different methods of forecasting future values of mean duration of stay and its subsequent use in the formation of hospital bed requirements. RESULTS--It has been suggested that the simple trend fitting approach suffers from model specification error and imposes unjustified restrictions on the data. Time series approach (Box-Jenkins method) was shown to be a more appropriate way of modelling the data. CONCLUSION--The simple trend fitting approach is inferior to the time series approach in modelling hospital bed requirements. PMID:2277253

  14. Construct-a-Catapult. Science by Design Series.

    ERIC Educational Resources Information Center

    Pulis, Lee

    This book is one of four books in the Science-by-Design Series crated by TERC and funded by the National Science Foundation (NSF). It integrates history, physics, mathematics, and technology in its challenge to high school students to design and build a working catapult system. Students investigate elasticity, projectile launching, and learn about…

  15. Construct-a-Boat. Science by Design Series.

    ERIC Educational Resources Information Center

    Baroway, William

    This book is one of four books in the Science-by-Design Series created by TERC and funded by the National Science Foundation (NSF). It challenges high school students to investigate the physics of boat performance and work with systems and modeling. Through research, design, testing, and evaluation of a model boat, students experience the…

  16. Examining the Internal Validity and Statistical Precision of the Comparative Interrupted Time Series Design by Comparison with a Randomized Experiment

    ERIC Educational Resources Information Center

    St.Clair, Travis; Cook, Thomas D.; Hallberg, Kelly

    2014-01-01

    Although evaluators often use an interrupted time series (ITS) design to test hypotheses about program effects, there are few empirical tests of the design's validity. We take a randomized experiment on an educational topic and compare its effects to those from a comparative ITS (CITS) design that uses the same treatment group as the experiment…

  17. 76 FR 68675 - Revisions to the Export Administration Regulations (EAR): Control of Aircraft and Related Items...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ...(g) of the July 15 proposed rule) and all other 600 series items if, at the time of export, reexport... designed'' for a defense article would become subject to the new 600 series controls on the CCL as... the extent an item is ``specially designed'' for a military use, it is subject to a 600 series ECCN in...

  18. Study design in medical research: part 2 of a series on the evaluation of scientific publications.

    PubMed

    Röhrig, Bernd; du Prel, Jean-Baptist; Blettner, Maria

    2009-03-01

    The scientific value and informativeness of a medical study are determined to a major extent by the study design. Errors in study design cannot be corrected afterwards. Various aspects of study design are discussed in this article. Six essential considerations in the planning and evaluation of medical research studies are presented and discussed in the light of selected scientific articles from the international literature as well as the authors' own scientific expertise with regard to study design. The six main considerations for study design are the question to be answered, the study population, the unit of analysis, the type of study, the measuring technique, and the calculation of sample size. This article is intended to give the reader guidance in evaluating the design of studies in medical research. This should enable the reader to categorize medical studies better and to assess their scientific quality more accurately.

  19. The Validity of the Comparative Interrupted Time Series Design for Evaluating the Effect of School-Level Interventions.

    PubMed

    Jacob, Robin; Somers, Marie-Andree; Zhu, Pei; Bloom, Howard

    2016-06-01

    In this article, we examine whether a well-executed comparative interrupted time series (CITS) design can produce valid inferences about the effectiveness of a school-level intervention. This article also explores the trade-off between bias reduction and precision loss across different methods of selecting comparison groups for the CITS design and assesses whether choosing matched comparison schools based only on preintervention test scores is sufficient to produce internally valid impact estimates. We conduct a validation study of the CITS design based on the federal Reading First program as implemented in one state using results from a regression discontinuity design as a causal benchmark. Our results contribute to the growing base of evidence regarding the validity of nonexperimental designs. We demonstrate that the CITS design can, in our example, produce internally valid estimates of program impacts when multiple years of preintervention outcome data (test scores in the present case) are available and when a set of reasonable criteria are used to select comparison organizations (schools in the present case). © The Author(s) 2016.

  20. Controlled generation of a single Trichel pulse and a series of single Trichel pulses in air

    NASA Astrophysics Data System (ADS)

    Mizeraczyk, Jerzy; Berendt, Artur; Akishev, Yuri

    2018-04-01

    In this paper, a simple method for the controlled generation of a single Trichel pulse or a series of single Trichel pulses of a regulated repetition frequency in air is proposed. The concept of triggering a single Trichel pulse or a series of such pulses is based on the precise controlling the voltage inception of the negative corona, which can be accomplished through the use of a ramp voltage pulse or a series of such pulses with properly chosen ramp voltage pulse parameters (rise and fall times, and ramp voltage pulse repetition frequency). The proposal has been tested in experiments using a needle-to-plate electrode arrangement in air, and reproducible Trichel pulses (single or in a series) were obtained by triggering them with an appropriately designed voltage waveform. The proposed method and results obtained have been qualitatively analysed. The analysis provides guidance for designing the voltage ramp pulse in respect of the generation of a single Trichel pulse or a series of single Trichel pulses. The controlled generation of a single Trichel pulse or a series of such pulses would be a helpful research tool for the refined studies of the fundamental processes in a negative corona discharge in a single- (air is an example) and multi-phase gaseous fluids. The controlled generation of a single Trichel pulse or a series of Trichel pulses can also be attractive for those corona treatments which need manipulation of the electric charge and heat portions delivered by the Trichel pulses to the object.

  1. Competitiveness Implications of Environmental Regulations: Case Studies (1992- 1997)

    EPA Pesticide Factsheets

    This collection of reports is part of a series of case studies designed to examine Michael Porter’s hypothesis that innovative companies responding to environmental regulation can create competitive advantage through lower costs or higher sales.

  2. Design and Implementation of a Professional Development Course Series.

    PubMed

    Welch, Beth; Spooner, Joshua J; Tanzer, Kim; Dintzner, Matthew R

    2017-12-01

    Objective. To design and implement a longitudinal course series focused on professional development and professional identity formation in pharmacy students at Western New England University. Methods. A four-year, theme-based course series was designed to sequentially and longitudinally impart the values, attributes, and characteristics of a professional pharmacist. Requirements of the course include: goal planning and reflective assignments, submission of "Best Works," attendance at professional meetings, completion of service hours, annual completion of a Pharmacy Professionalism Instrument, attendance at Dean's Seminar, participation in roundtable discussions, and maintenance of an electronic portfolio. Though the Professional Development course series carries no credit, these courses are progression requirements and students are assessed on a pass/fail basis. Results. Course pass rates in the 2015-2016 academic year for all four classes were 99% to 100%, suggesting the majority of students take professional development seriously and are achieving the intended outcomes of the courses. Conclusion. A professional development course series was designed and implemented in the new Doctor of Pharmacy program at Western New England University to enhance the professional identity formation of students.

  3. Study design and hierarchy of evidence for surgical decision making.

    PubMed

    Sprague, Sheila; McKay, Paula; Thoma, Achilleas

    2008-04-01

    This article provides a historical overview of the hierarchy of evidence for surgical decision making and discusses key study designs in the hierarchy of evidence. This encompasses meta-analyses, randomized controlled trials, and observational studies, including cohort and case-controlled studies, case series and case reports, and basic science studies. This article also reviews the principles and importance of evidence-based plastic surgery and describes several systems to rate the strength of the scientific evidence.

  4. Interactional Patterns Among Dental School Students and the Influence of Building Design. Final Progress Report on the Planning Study: Behavioral Factors in Dental School Design.

    ERIC Educational Resources Information Center

    Myrick, Richard; Marx, Barbara S.

    The relationship of architecture to human behavior is a topic of increasing concern both to designers and behavioral scientists. To further evaluate the extent of the relationship a series of preliminary investigations has been undertaken. The primary means of measurement was informal conversations of dental students as related to the…

  5. The influence of actuator materials and nozzle designs on electrostatic charge of pressurised metered dose inhaler (pMDI) formulations.

    PubMed

    Chen, Yang; Young, Paul M; Fletcher, David F; Chan, Hak Kim; Long, Edward; Lewis, David; Church, Tanya; Traini, Daniela

    2014-05-01

    To investigate the influence of different actuator materials and nozzle designs on the electrostatic charge properties of a series of solution metered dose inhaler (pMDI) aerosols. Actuators were manufactured with flat and cone nozzle designs using five different materials from the triboelectric series (Nylon, Polyethylene terephthalate, Polyethylene-High density, Polypropylene copolymer and Polytetrafluoroethylene). The electrostatic charge profiles of pMDI containing beclomethasone dipropionate (BDP) as model drug in HFA-134a propellant, with different concentrations of ethanol were studied. Electrostatic measurements were taken using a modified electrical low-pressure impactor (ELPI) and the deposited drug mass assayed chemically using HPLC. The charge profiles of HFA 134a alone have shown strong electronegativity with all actuator materials and nozzle designs, at an average of -1531.34 pC ± 377.34. The presence of co-solvent ethanol significantly reduced the negative charge magnitude. BDP reduced the suppressing effect of ethanol on the negative charging of the propellant. For all tested formulations, the flat nozzle design showed no significant differences in net charge between different actuator materials, whereas the charge profiles of cone designs followed the triboelectric series. The electrostatic charging profiles from a solution pMDI containing BDP and ethanol can be significantly influenced by the actuator material, nozzle design and formulation components. Ethanol concentration appears to have the most significant impact. Furthermore, BDP interactions with ethanol and HFA have an influence on the electrostatic charge of aerosols. By choosing different combinations of actuator materials and orifice design, the fine particle fractions of formulations can be altered.

  6. Ambient temperature and coronary heart disease mortality in Beijing, China: a time series study

    PubMed Central

    2012-01-01

    Background Many studies have examined the association between ambient temperature and mortality. However, less evidence is available on the temperature effects on coronary heart disease (CHD) mortality, especially in China. In this study, we examined the relationship between ambient temperature and CHD mortality in Beijing, China during 2000 to 2011. In addition, we compared time series and time-stratified case-crossover models for the non-linear effects of temperature. Methods We examined the effects of temperature on CHD mortality using both time series and time-stratified case-crossover models. We also assessed the effects of temperature on CHD mortality by subgroups: gender (female and male) and age (age > =65 and age < 65). We used a distributed lag non-linear model to examine the non-linear effects of temperature on CHD mortality up to 15 lag days. We used Akaike information criterion to assess the model fit for the two designs. Results The time series models had a better model fit than time-stratified case-crossover models. Both designs showed that the relationships between temperature and group-specific CHD mortality were non-linear. Extreme cold and hot temperatures significantly increased the risk of CHD mortality. Hot effects were acute and short-term, while cold effects were delayed by two days and lasted for five days. The old people and women were more sensitive to extreme cold and hot temperatures than young and men. Conclusions This study suggests that time series models performed better than time-stratified case-crossover models according to the model fit, even though they produced similar non-linear effects of temperature on CHD mortality. In addition, our findings indicate that extreme cold and hot temperatures increase the risk of CHD mortality in Beijing, China, particularly for women and old people. PMID:22909034

  7. Comparison of estimators for rolling samples using Forest Inventory and Analysis data

    Treesearch

    Devin S. Johnson; Michael S. Williams; Raymond L. Czaplewski

    2003-01-01

    The performance of three classes of weighted average estimators is studied for an annual inventory design similar to the Forest Inventory and Analysis program of the United States. The first class is based on an ARIMA(0,1,1) time series model. The equal weight, simple moving average is a member of this class. The second class is based on an ARIMA(0,2,2) time series...

  8. Chain Reaction. Culture and Social Organization Booklet 3. Teacher's Edition=Reaccion en cadena. Cultura y organizacion social libro 3. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Polytechnic Univ., Pomona. National Multilingual Multicultural Materials Development Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  9. Let's Help Each Other. Economic Organization Booklet 3. Teacher's Edition=Ayudemonos uno al otro. Organizacion economica libro 3. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  10. From Here to There. Economic Organization Booklet 2. Teacher's Edition=De aqui a alla. Organizacion economica libro 2. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  11. Learning from Multiple Cases: A New Paradigm for Investigating the Effects of Clinical Experience on Knowledge Restructuring and Knowledge Acquisition.

    ERIC Educational Resources Information Center

    Boshuizen, Henny P. A.; Bongaerts, Maureen Machiels; van de Wiel, Margaretha W. J.; Schmidt, Henk G.

    The effects of experience with a series of similar cases on the knowledge restructuring and learning from text were studied in a longitudinal design. Two groups of fourth-year medical students were confronted with a series of cases, part of them having the same underlying disease. The cases were interspersed with fillers, and each set of cases had…

  12. The Irish: In Their Homeland, In America, In Connecticut. The Peoples of Connecticut Multicultural Ethnic Heritage Studies Series, Number One.

    ERIC Educational Resources Information Center

    Stone, Frank Andrews

    The curriculum guide is designed to promote understanding of Irish Americans and their culture in their homeland and in America. It is part of a series of guides about ethnic groups in America and in Connecticut. Written for grades nine through 12, the material is adaptable for younger readers or adults. A 15-question quiz to test students'…

  13. Limited Resources, Unlimited Wants. Environment Booklet 2. Teacher's Edition=Recursos limitados, deseos ilimitados. Libro del medio ambiente 2. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and are designed to help students understand some major human problems and make sound, responsive decisions to…

  14. Roots. Culture and Social Organization Booklet 1. Teacher's Edition=Raices. Cultura y organizacion social libro 1. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and are designed to help students understand some major human problems and make sound, responsive decisions to…

  15. New angles on energy correlation functions

    DOE PAGES

    Moult, Ian; Necib, Lina; Thaler, Jesse

    2016-12-29

    Jet substructure observables, designed to identify specific features within jets, play an essential role at the Large Hadron Collider (LHC), both for searching for signals beyond the Standard Model and for testing QCD in extreme phase space regions. In this paper, we systematically study the structure of infrared and collinear safe substructure observables, defining a generalization of the energy correlation functions to probe n-particle correlations within a jet. These generalized correlators provide a flexible basis for constructing new substructure observables optimized for specific purposes. Focusing on three major targets of the jet substructure community — boosted top tagging, boosted W/Z/Hmore » tagging, and quark/gluon discrimination — we use power-counting techniques to identify three new series of powerful discriminants: M i, N i, and U i. The Mi series is designed for use on groomed jets, providing a novel example of observables with improved discrimination power after the removal of soft radiation. The N i series behave parametrically like the N -subjettiness ratio observables, but are defined without respect to subjet axes, exhibiting improved behavior in the unresolved limit. Finally, the U i series improves quark/gluon discrimination by using higher-point correlators to simultaneously probe multiple emissions within a jet. Taken together, these observables broaden the scope for jet substructure studies at the LHC.« less

  16. New angles on energy correlation functions

    NASA Astrophysics Data System (ADS)

    Moult, Ian; Necib, Lina; Thaler, Jesse

    2016-12-01

    Jet substructure observables, designed to identify specific features within jets, play an essential role at the Large Hadron Collider (LHC), both for searching for signals beyond the Standard Model and for testing QCD in extreme phase space regions. In this paper, we systematically study the structure of infrared and collinear safe substructure observables, defining a generalization of the energy correlation functions to probe n-particle correlations within a jet. These generalized correlators provide a flexible basis for constructing new substructure observables optimized for specific purposes. Focusing on three major targets of the jet substructure community — boosted top tagging, boosted W/Z/H tagging, and quark/gluon discrimination — we use power-counting techniques to identify three new series of powerful discriminants: M i , N i , and U i . The M i series is designed for use on groomed jets, providing a novel example of observables with improved discrimination power after the removal of soft radiation. The N i series behave parametrically like the N -subjettiness ratio observables, but are defined without respect to subjet axes, exhibiting improved behavior in the unresolved limit. Finally, the U i series improves quark/gluon discrimination by using higher-point correlators to simultaneously probe multiple emissions within a jet. Taken together, these observables broaden the scope for jet substructure studies at the LHC.

  17. Time series smoother for effect detection.

    PubMed

    You, Cheng; Lin, Dennis K J; Young, S Stanley

    2018-01-01

    In environmental epidemiology, it is often encountered that multiple time series data with a long-term trend, including seasonality, cannot be fully adjusted by the observed covariates. The long-term trend is difficult to separate from abnormal short-term signals of interest. This paper addresses how to estimate the long-term trend in order to recover short-term signals. Our case study demonstrates that the current spline smoothing methods can result in significant positive and negative cross-correlations from the same dataset, depending on how the smoothing parameters are chosen. To circumvent this dilemma, three classes of time series smoothers are proposed to detrend time series data. These smoothers do not require fine tuning of parameters and can be applied to recover short-term signals. The properties of these smoothers are shown with both a case study using a factorial design and a simulation study using datasets generated from the original dataset. General guidelines are provided on how to discover short-term signals from time series with a long-term trend. The benefit of this research is that a problem is identified and characteristics of possible solutions are determined.

  18. Time series smoother for effect detection

    PubMed Central

    Lin, Dennis K. J.; Young, S. Stanley

    2018-01-01

    In environmental epidemiology, it is often encountered that multiple time series data with a long-term trend, including seasonality, cannot be fully adjusted by the observed covariates. The long-term trend is difficult to separate from abnormal short-term signals of interest. This paper addresses how to estimate the long-term trend in order to recover short-term signals. Our case study demonstrates that the current spline smoothing methods can result in significant positive and negative cross-correlations from the same dataset, depending on how the smoothing parameters are chosen. To circumvent this dilemma, three classes of time series smoothers are proposed to detrend time series data. These smoothers do not require fine tuning of parameters and can be applied to recover short-term signals. The properties of these smoothers are shown with both a case study using a factorial design and a simulation study using datasets generated from the original dataset. General guidelines are provided on how to discover short-term signals from time series with a long-term trend. The benefit of this research is that a problem is identified and characteristics of possible solutions are determined. PMID:29684033

  19. Problem Implementation as a Lever for Change: An Experimental Study of the Effects of a Professional Development Program on Students' Mathematics Learning

    ERIC Educational Resources Information Center

    Santagata, Rossella; Kersting, Nicole; Givvin, Karen B.; Stigler, James W.

    2011-01-01

    This study investigates, through an experimental design, the effectiveness of a professional development program on teacher knowledge and practices and on student learning. The program consisted of a series of video-based modules designed to respond to needs of U.S. teachers, as highlighted by findings from the 1999 Third International Mathematics…

  20. Urban Children in Distress: An Introduction to the Issues. Innocenti Occasional Papers. The Urban Child Series, Number 2.

    ERIC Educational Resources Information Center

    Blanc, Cristina S.

    This publication presents a discussion of the status of poor urban children world-wide and the design of a five-nation study of the condition of distressed urban children. Following an introduction, Section 2 describes the urban child project designed to study and advance the plight of urban children in developing nations. Section 3 outlines the…

  1. ACT-CCREC Core Research Program: Study Questions and Design. ACT Working Paper Series. WP-2015-01

    ERIC Educational Resources Information Center

    Cruce, Ty M.

    2015-01-01

    This report provides a non-technical overview of the guiding research questions and research design for the ACT-led core research program conducted on behalf of the GEAR UP College and Career Readiness Evaluation Consortium (CCREC). The core research program is a longitudinal study of the effectiveness of 14 GEAR UP state grants on the academic…

  2. Earth Observatory Satellite system definition study. Report 3: Design cost trade-off studies and recommendations

    NASA Technical Reports Server (NTRS)

    1974-01-01

    An analysis of the design and cost tradeoff aspects of the Earth Observatory Satellite (EOS) development is presented. The design/cost factors that affect a series of mission/system level concepts are discussed. The subjects considered are as follows: (1) spacecraft subsystem cost tradeoffs, (2) ground system cost tradeoffs, and (3) program cost summary. Tables of data are provided to summarize the results of the analyses. Illustrations of the various spacecraft configurations are included.

  3. Investigation of Microcavitation-Induced Effects using in Vitro Models for Traumatic Brain Injury

    DTIC Science & Technology

    2016-08-25

    four MOSFET switches (IXFB38N I OOQ2) stacking in series . The designing details of such stacking circuit can be found in [25] . In brief, the gate... time of the mechanical vibration of the piezotransducer. The on- time in this study was limited to ~2 s. B. Microbubble chamber design Rev. Sci...60 s. This long collapse time may be favored for biological studies where the observation of time evolution is of essence. We purposely designed the

  4. Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis.

    PubMed

    Kim, Okseon; Jeong, Yujeong; Lee, Hyunseung; Hong, Sun-Sun; Hong, Sungwoo

    2011-04-14

    Phosphatidylinositol 3-kinase α (PI3Kα) is an important regulator of intracellular signaling pathways, controlling remarkably diverse arrays of physiological processes. Because the PI3K pathway is frequently up-regulated in human cancers, the inhibition of PI3Kα can be a promising approach to cancer therapy. In this study, we have designed and synthesized a new series of imidazo[1,2-a]pyridine derivatives as PI3Kα inhibitors through the fragment-growing strategy. By varying groups at the 3- and 6-positions of imidazo[1,2-a]pyridines, we studied the structure-activity relationships (SAR) profiles and identified a series of potent PI3Kα inhibitors. Representative derivatives showed good activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited noteworthy antiangiogenic activity.

  5. Gfr Core Neutronics Studies at CEA

    NASA Astrophysics Data System (ADS)

    Bosq, J. C.; Brun-Magaud, V.; Rimpault, G.; Tommasi, J.; Conti, A.; Garnier, J. C.

    2006-04-01

    The Gas cooled Fast Reactor (GFR) is a high priority in the CEA R&D program on Future Nuclear Energy Systems. After preliminary neutronics and thermo-aerolic studies, a first He-cooled 2400MWth core design based on a series of carbide CERCER plates arranged in an hexagonal wrapper were selected. Although GFR subassembly and core design studies are still at an early stage of development, it is nonetheless possible to identify a number of nuclear data needs that could have some impact on the actual design: new materials, decay heat contributors….

  6. 77 FR 71399 - Notice of Public Workshop: Blueprint for Action: Workshop on the Design of the National Network...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ...).'' This workshop series provides a forum for the AMNPO to present the proposed design of the National...: Blueprint for Action: Workshop on the Design of the National Network for Manufacturing Innovation (NNMI... Standards and Technology (NIST), announces the first workshop in a new series of public workshops entitled...

  7. Apparel Design and Production: A Suggested Program Guide. Fashion Industry Series No. 2.

    ERIC Educational Resources Information Center

    Fashion Inst. of Tech., New York, NY.

    The apparel design and production guide is the second of a series of five interrelated program resource guides encompassing the various dimensions of the fashion industry. Designed to provide youths and adults with intensive preparation for initial entry employment and also with career advancement opportunities within specific categories of jobs,…

  8. Undertaking Experiments in Social Sciences: Sequential, Multiple Time Series Designs for Consideration

    ERIC Educational Resources Information Center

    Phan, Huy P.; Ngu, Bing H.

    2017-01-01

    In social sciences, the use of stringent methodological approaches is gaining increasing emphasis. Researchers have recognized the limitations of cross-sectional, non-manipulative data in the study of causality. True experimental designs, in contrast, are preferred as they represent rigorous standards for achieving causal flows between variables.…

  9. Nudging Waste Diversion at Western State Colorado University: Application of Behavioral Insights

    ERIC Educational Resources Information Center

    McCoy, Kimberly; Oliver, Justin J.; Borden, D. Scott; Cohn, Scott I.

    2018-01-01

    Purpose: This paper aims to test a nudge, or intervention, designed through behavioral insights at a university campus to discover cost-effective means for increasing recycling participation and methods for estimating waste removal cost savings. Design/methodology/approach: A series of studies were conducted demonstrating the effectiveness of…

  10. Demonstration-Based Training (DBT) in the Design of a Video Tutorial for Software Training

    ERIC Educational Resources Information Center

    van der Meij, Hans; van der Meij, Jan

    2016-01-01

    This study investigates the design and effectiveness of a video tutorial for software training. In accordance with demonstration-based training, the tutorial consisted of a series of task demonstrations, with instructional features added to enhance learning. An experiment is reported in which a demonstration-only control condition was compared…

  11. Studios Abroad: A Challenge in Innovative Pedagogy

    ERIC Educational Resources Information Center

    Macedo, Joseli

    2017-01-01

    Study abroad programs offer a unique opportunity to evaluate pedagogic models. The role of studios in design and planning pedagogy has been examined. However, how the general framework of a studio supports other pedagogic models has not been widely discussed. This article assesses a series of urban planning and design studios conducted abroad to…

  12. Mathematics: PROJECT DESIGN. Educational Needs, Fresno, 1968, Number 12.

    ERIC Educational Resources Information Center

    Smart, James R.

    This report examines and summarizes the needs in mathematics of the Fresno City school system. The study is one in a series of needs assessment reports for PROJECT DESIGN, an ESEA Title III project administered by the Fresno City Unified School District. Theoretical concepts, rather than computational drill, would be emphasized in the proposed…

  13. The Impact of a Service-Learning Design Course on White Students' Racial Attitudes

    ERIC Educational Resources Information Center

    Houshmand, Sara; Spanierman, Lisa B.; Beer, Amanda M.; Poteat, V. Paul; Lawson, Laura J.

    2014-01-01

    This study examined the racial attitudes of White undergraduates (N = 15) enrolled in a service-learning design studio, in which students worked closely on landscape architecture projects with residents in a low-income African American community. Using a modified consensual qualitative research method, the authors analyzed a series of guided…

  14. 38 CFR 1.17 - Evaluation of studies relating to health effects of radiation exposure.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... health effects of radiation exposure. (a) From time to time, the Secretary shall publish evaluations of... paragraph a valid study is one which: (i) Has adequately described the study design and methods of data... studies affecting epidemiological assessments including case series, correlational studies and studies...

  15. 38 CFR 1.17 - Evaluation of studies relating to health effects of radiation exposure.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... health effects of radiation exposure. (a) From time to time, the Secretary shall publish evaluations of... paragraph a valid study is one which: (i) Has adequately described the study design and methods of data... studies affecting epidemiological assessments including case series, correlational studies and studies...

  16. 38 CFR 1.17 - Evaluation of studies relating to health effects of radiation exposure.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... health effects of radiation exposure. (a) From time to time, the Secretary shall publish evaluations of... paragraph a valid study is one which: (i) Has adequately described the study design and methods of data... studies affecting epidemiological assessments including case series, correlational studies and studies...

  17. 38 CFR 1.17 - Evaluation of studies relating to health effects of radiation exposure.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... health effects of radiation exposure. (a) From time to time, the Secretary shall publish evaluations of... paragraph a valid study is one which: (i) Has adequately described the study design and methods of data... studies affecting epidemiological assessments including case series, correlational studies and studies...

  18. 38 CFR 1.17 - Evaluation of studies relating to health effects of radiation exposure.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... health effects of radiation exposure. (a) From time to time, the Secretary shall publish evaluations of... paragraph a valid study is one which: (i) Has adequately described the study design and methods of data... studies affecting epidemiological assessments including case series, correlational studies and studies...

  19. Ground Operations Aerospace Language (GOAL). Volume 1: Study overview

    NASA Technical Reports Server (NTRS)

    1973-01-01

    A series of NASA and Contractor studies sponsored by NASA/KSC resulted in a specification for the Ground Operations Aerospace Language (GOAL). The Cape Kennedy Facility of the IBM Corporation was given the responsibility, under existing contracts, to perform an analysis of the Language Specification, to design and develop a GOAL Compiler, to provide a specification for a data bank, to design and develop an interpretive code translator, and to perform associated application studies.

  20. Single subject design: Use of time series analyses in a small cohort to understand adherence with a prescribed fluid restriction.

    PubMed

    Reilly, Carolyn Miller; Higgins, Melinda; Smith, Andrew; Culler, Steven D; Dunbar, Sandra B

    2015-11-01

    This paper presents a secondary in-depth analysis of five persons with heart failure randomized to receive an education and behavioral intervention on fluid restriction as part of a larger study. Using a single subject analysis design, time series analyses models were constructed for each of the five patients for a period of 180 days to determine correlations between daily measures of patient reported fluid intake, thoracic impedance, and weights, and relationships between patient reported outcomes of symptom burden and health related quality of life over time. Negative relationships were observed between fluid intake and thoracic impedance, and between impedance and weight, while positive correlations were observed between daily fluid intake and weight. By constructing time series analyses of daily measures of fluid congestion, trends and patterns of fluid congestion emerged which could be used to guide individualized patient care or future research endeavors. Employment of such a specialized analysis technique allows for the elucidation of clinically relevant findings potentially disguised when only evaluating aggregate outcomes of larger studies. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. The examination of headache activity using time-series research designs.

    PubMed

    Houle, Timothy T; Remble, Thomas A; Houle, Thomas A

    2005-05-01

    The majority of research conducted on headache has utilized cross-sectional designs which preclude the examination of dynamic factors and principally rely on group-level effects. The present article describes the application of an individual-oriented process model using time-series analytical techniques. The blending of a time-series approach with an interactive process model allows consideration of the relationships of intra-individual dynamic processes, while not precluding the researcher to examine inter-individual differences. The authors explore the nature of time-series data and present two necessary assumptions underlying the time-series approach. The concept of shock and its contribution to headache activity is also presented. The time-series approach is not without its problems and two such problems are specifically reported: autocorrelation and the distribution of daily observations. The article concludes with the presentation of several analytical techniques suited to examine the time-series interactive process model.

  2. Introduction to the Special Series: Current Directions for Measuring Parenting Constructs to Inform Prevention Science.

    PubMed

    Lindhiem, Oliver; Shaffer, Anne

    2017-04-01

    Parenting behaviors are multifaceted and dynamic and therefore challenging to quantify. Measurement methods have critical implications for study results, particularly for prevention trials designed to modify parenting behaviors. Although multiple approaches can complement one another and contribute to a more complete understanding of prevention trials, the assumptions and implications of each approach are not always clearly addressed. Greater attention to the measurement of complex constructs such as parenting is needed to advance the field of prevention science. This series examines the challenges of measuring changes in parenting behaviors in the context of prevention trials. All manuscripts in the special series address measurement issues and make practical recommendations for prevention researchers. Manuscripts in this special series include (1) empirical studies that demonstrate novel measurement approaches, (2) re-analyses of prevention trial outcome data directly comparing and contrasting two or more methods, and (3) a statistical primer and practical guide to analyzing proportion data.

  3. Research subject privacy protection in otolaryngology.

    PubMed

    Noone, Michael C; Walters, K Christian; Gillespie, M Boyd

    2004-03-01

    Health Insurance Portability and Accountability Act regulations, which took effect on April 14, 2003, placed new constraints on the use of protected health information for research purposes. To review practices of research subject privacy protection in otolaryngology in order to determine steps necessary to achieve compliance with Health Insurance Portability and Accountability Act regulations. Literature review. Articles appearing in 2001 in 3 widely circulated otolaryngology journals were classified according to study design. The "Methods" section of each article was reviewed to determine whether the informed consent and institutional review board processes were clearly documented. Descriptive studies involving case reports and case series were more common than observational studies that include a control group (66% vs 11%). Few case series documented the consent process (18%) and institutional review board process (19%). Observational designs demonstrated better documentation of the consent process (P<.001) and the institutional review board exemption and approval process (P<.001). Methods used to protect subject privacy are not commonly documented in case series in otolaryngology. More attention needs to be given to research subject privacy concerns in the otolaryngology literature in order to comply with Health Insurance Portability and Accountability Act regulations.

  4. Gardening from a Wheelchair

    MedlinePlus

    ... your function in the garden. Match your garden's design to your individual needs." Trying to push beyond ... sports Team sports Winter sports Video: Handcycling Video series: Accessible gardening Video series: Exercise tips Video series: ...

  5. Area Handbook Series: Zimbabwe: A Country Study

    DTIC Science & Technology

    1982-08-01

    not be construed as an official Department of the Army position, policy, or decision, unless so designated by other official documentation. The authors...see table A). Claimed in the late nineteenth century by Cecil Rhodes’ British South Africa Company as part of a larger territory designated Rhodesia...has used the term Rhodesia except in situations where the historical significance of the other designations appears more appropriate to the reader’s

  6. Morse Brothers, Inc. Harrisburg plant : high-strength concrete : research study.

    DOT National Transportation Integrated Search

    1987-07-01

    This report is the seventh in a series of research studies designed to determine the difference in strength of concrete cylinders cast in steel molds vs. cylinders cast in plastic molds. Prior to this report, six other research studies on the differe...

  7. Overview of risk assessment in new EPA epidemiology studies

    EPA Science Inventory

    Since 2003, the Office of Research and Development of the US Environmental Protection Agency has conducted a series of epidemiology studies of water quality and health effects among beach goers at beaches across the United States. These studies are designed to establish associati...

  8. 75 FR 9002 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-26

    ... Guide, DG-3040, ``Design, Construction, and Inspection of Embankment Retention Systems at Fuel Cycle... guide in the agency's ``Regulatory Guide'' series. This series was developed to describe and make... to be satisfactory for the design, construction, and inspection of embankment retention systems used...

  9. Instructional Systems. The Educational Technology Reviews Series. Number Eight.

    ERIC Educational Resources Information Center

    Educational Technology Publications, Englewood Cliffs, NJ.

    Composed of articles which appeared recently in "Educational Technology" magazine, this volume in the review series considers instructional systems. Topics covered include systems models for instructional design and management, the design of simulation systems, informal and vocational education, individualized instruction, operational learning…

  10. Economic analysis of Darrieus vertical axis wind turbine systems for the generation of utility grid electrical power. Volume IV. Summary and analysis of the A. T. Kearney and Alcoa Laboratories point design economic studies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sullivan, W.N.; Nellums, R.O.

    1979-08-01

    The A.T. Kearney and Alcoa economic studies are two independent attempts to assess the installed costs of a series of six Darrieus vertical axis wind turbine designs. The designs cover a range of sizes with peak outputs from 10 to 1600 kW. All are designed to produce utility grid electrical power. Volume IV of this report summarizes, compares, and analyzes the results of these studies. The Kearney and Alcoa final reports are included in the Appendices.

  11. Economic analysis of Darrieus vertical axis wind turbine systems for the generation of utility grid electrical power. Volume IV: summary and analysis of the A. T. Kearney and Alcoa Laboratories point design economic studies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sullivan, W.N.; Nellums, R.O.

    1979-08-01

    The A. T. Kearney and Alcoa economic studies are two independent attempts to assess the installed costs of a series of six Darrieus vertical axis wind turbine designs. The designs cover a range of sizes with peak outputs from 10 to 1600 kW. All are designed to produce utility grid electrical power. Volume IV of this report summarizes, compares, and analyzes the results of these studies. The Kearney and Alcoa final reports are included in the Appendices.

  12. Bandwidth based methodology for designing a hybrid energy storage system for a series hybrid electric vehicle with limited all electric mode

    NASA Astrophysics Data System (ADS)

    Shahverdi, Masood

    The cost and fuel economy of hybrid electrical vehicles (HEVs) are significantly dependent on the power-train energy storage system (ESS). A series HEV with a minimal all-electric mode (AEM) permits minimizing the size and cost of the ESS. This manuscript, pursuing the minimal size tactic, introduces a bandwidth based methodology for designing an efficient ESS. First, for a mid-size reference vehicle, a parametric study is carried out over various minimal-size ESSs, both hybrid (HESS) and non-hybrid (ESS), for finding the highest fuel economy. The results show that a specific type of high power battery with 4.5 kWh capacity can be selected as the winning candidate to study for further minimization. In a second study, following the twin goals of maximizing Fuel Economy (FE) and improving consumer acceptance, a sports car class Series-HEV (SHEV) was considered as a potential application which requires even more ESS minimization. The challenge with this vehicle is to reduce the ESS size compared to 4.5 kWh, because the available space allocation is only one fourth of the allowed battery size in the mid-size study by volume. Therefore, an advanced bandwidth-based controller is developed that allows a hybridized Subaru BRZ model to be realized with a light ESS. The result allows a SHEV to be realized with 1.13 kWh ESS capacity. In a third study, the objective is to find optimum SHEV designs with minimal AEM assumption which cover the design space between the fuel economies in the mid-size car study and the sports car study. Maximizing FE while minimizing ESS cost is more aligned with customer acceptance in the current state of market. The techniques applied to manage the power flow between energy sources of the power-train significantly affect the results of this optimization. A Pareto Frontier, including ESS cost and FE, for a SHEV with limited AEM, is introduced using an advanced bandwidth-based control strategy teamed up with duty ratio control. This controller allows the series hybrid's advantage of tightly managing engine efficiency to be extended to lighter ESS, as compared to the size of the ESS in available products in the market.

  13. An Interrupted Time Series Analysis of the State College Nuisance Property Ordinance and an Assessment of Rental Property Managers as Place Manager/Intimate Handler of Offender

    ERIC Educational Resources Information Center

    Koehle, Gregory M.

    2011-01-01

    This research involves a legal impact study of the State College Nuisance Property Ordinance and an assessment of State College Rental Property Managers in the role of place manager/intimate handler of offender. The impact of the Ordinance was assessed by employing an interrupted time series design which examined five years of pre-ordinance…

  14. You and Beyond. Culture and Social Organization Booklet 2. Teacher's Edition=Tu y mas alla. Cultura y organizacion social libro 2. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  15. Does the Well-Being of Individuals with Down Syndrome and Dementia Improve When Using Life Story Books and Rummage Boxes? A Randomized Single Case Series Experiment

    ERIC Educational Resources Information Center

    Crook, Nicola; Adams, Malcolm; Shorten, Nicola; Langdon, Peter E.

    2016-01-01

    Background: This study investigated whether a personalized life story book and rummage box enhanced well-being and led to changes in behaviour for people with Down syndrome (DS) who have dementia. Materials and Methods: A randomized single case series design was used with five participants who had DS and a diagnosis of dementia. Participants were…

  16. Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.

    PubMed

    Tran, Thien-Duc; Pryde, David C; Jones, Peter; Adam, Fiona M; Benson, Neil; Bish, Gerwyn; Calo, Frederick; Ciaramella, Guiseppe; Dixon, Rachel; Duckworth, Jonathan; Fox, David N A; Hay, Duncan A; Hitchin, James; Horscroft, Nigel; Howard, Martin; Gardner, Iain; Jones, Hannah M; Laxton, Carl; Parkinson, Tanya; Parsons, Gemma; Proctor, Katie; Smith, Mya C; Smith, Nicholas; Thomas, Amy

    2011-04-15

    The synthesis and structure-activity relationships of a series of novel interferon inducers are described. Pharmacokinetic studies and efficacy assessment of a series of 8-oxo-3-deazapurine analogues led to the identification of compound 33, a potent and selective agonist of the TLR7 receptor with an excellent in vivo efficacy profile in a mouse model. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Differentiation of Period, Age, and Cohort Effects on Drug Use 1976-1986. Monitoring the Future Occasional Paper Series, Paper 22.

    ERIC Educational Resources Information Center

    O'Malley, Patrick M.; And Others

    Conducted as part of the Monitoring the Future project, this study used a cohort-sequential design to examine period, age, and cohort effects on substance use among American youth between the ages of 18 and 28 from the high school classes of 1976 to 1986. This manuscript supersedes Paper 14 in the series which reported on American youth from 18-24…

  18. The Rise of Organized Labor: Workers, Employers, and the Public Interest. Public Issues Series.

    ERIC Educational Resources Information Center

    Stewart, James; Giese, James R.

    This booklet is part of a series of units designed to help students take and defend a position on public issues. The booklet is premised on the idea that the study of how various labor-related conflicts were resolved in the past can throw light on the problem of how they ought to be resolved here and now. That is why this particular unit looks at…

  19. Fault Tolerant Hardware/Software Architecture for Flight Critical Function

    DTIC Science & Technology

    1985-09-01

    Applications Studies Programme. The results of AGARD work are reported to the member nations and the NATO Authorities through the AGARD series of...systems, and is being advocated as a defense against design deficiencies which can plague software. - -- -- z--mm-L ___ K A critical application area for...day of the lecture series concludes with part I of a paper on the ;use of the Ada programming language In flight critical applications . Ada has been

  20. Personality Module. Test Booklet. Test Items for Booklets 1, 2, 3=Modulo de personalidad. Libro de prueba. Itemes de prueba para los libros 1, 2, 3.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  1. An Experimental Study of a Televised Science Series, Grades 1-4, Comparing the Quality and Sequence of Television and Classroom Questions with a Proposed Strategy of Science Instruction.

    ERIC Educational Resources Information Center

    Beisenherz, Paul Chalmers

    The effectiveness of a televised science series used in the Seattle metropolitan area was investigated, using factorial design to provide a treatment variable representing four degrees of utilization of TV science and non-TV science. Teachers and their intact classes were randomly assigned to one of four treatment groups: TV science only, plus…

  2. A New Trend-Following Indicator: Using SSA to Design Trading Rules

    NASA Astrophysics Data System (ADS)

    Leles, Michel Carlo Rodrigues; Mozelli, Leonardo Amaral; Guimarães, Homero Nogueira

    Singular Spectrum Analysis (SSA) is a non-parametric approach that can be used to decompose a time-series as trends, oscillations and noise. Trend-following strategies rely on the principle that financial markets move in trends for an extended period of time. Moving Averages (MAs) are the standard indicator to design such strategies. In this study, SSA is used as an alternative method to enhance trend resolution in comparison with the traditional MA. New trading rules using SSA as indicator are proposed. This paper shows that for the Down Jones Industrial Average (DJIA) and Shangai Securities Composite Index (SSCI) time-series the SSA trading rules provided, in general, better results in comparison to MA trading rules.

  3. Experimental research on air propellers

    NASA Technical Reports Server (NTRS)

    Durand, William F

    1918-01-01

    The purposes of the experimental investigation on the performance of air propellers described in this report are as follows: (1) the development of a series of design factors and coefficients drawn from model forms distributed with some regularity over the field of air-propeller design and intended to furnish a basis of check with similar work done in other aerodynamic laboratories, and as a point of departure for the further study of special or individual types and forms; (2) the establishment of a series of experimental values derived from models and intended for later use as a basis for comparison with similar results drawn from certain selected full-sized forms and tested in free flight.

  4. SAMPLE DESIGN CONSIDERATIONS FOR INDOOR AIR EXPOSURE SURVEYS

    EPA Science Inventory

    Recent studies have shown that the traditional practice of monitoring outdoor (ambient) air quality leads to little information regarding the exposures of people in indoor surroundings. Consequently, EPA has begun a series of studies to determine the air pollution exposures peopl...

  5. Environmental Approaches to Prehistory/Archaeology. Activities Designed to Supplement a Course in North American Prehistory/Archaeology at the Junior High or High School Level. Curriculum Series, Number 2.

    ERIC Educational Resources Information Center

    Carpenter, James C.; Fraser, Kathryn M.

    Presented are 17 activities designed to supplement junior or senior high school studies in prehistory and archaeology. Stressed throughout the manual is the changing relationship between humans and the environment. The learning experiences fall into three categories: (1) how we study prehistoric cultures, (2) how prehistoric peoples lived, and (3)…

  6. Enabling Web-Based Analysis of CUAHSI HIS Hydrologic Data Using R and Web Processing Services

    NASA Astrophysics Data System (ADS)

    Ames, D. P.; Kadlec, J.; Bayles, M.; Seul, M.; Hooper, R. P.; Cummings, B.

    2015-12-01

    The CUAHSI Hydrologic Information System (CUAHSI HIS) provides open access to a large number of hydrological time series observation and modeled data from many parts of the world. Several software tools have been designed to simplify searching and access to the CUAHSI HIS datasets. These software tools include: Desktop client software (HydroDesktop, HydroExcel), developer libraries (WaterML R Package, OWSLib, ulmo), and the new interactive search website, http://data.cuahsi.org. An issue with using the time series data from CUAHSI HIS for further analysis by hydrologists (for example for verification of hydrological and snowpack models) is the large heterogeneity of the time series data. The time series may be regular or irregular, contain missing data, have different time support, and be recorded in different units. R is a widely used computational environment for statistical analysis of time series and spatio-temporal data that can be used to assess fitness and perform scientific analyses on observation data. R includes the ability to record a data analysis in the form of a reusable script. The R script together with the input time series dataset can be shared with other users, making the analysis more reproducible. The major goal of this study is to examine the use of R as a Web Processing Service for transforming time series data from the CUAHSI HIS and sharing the results on the Internet within HydroShare. HydroShare is an online data repository and social network for sharing large hydrological data sets such as time series, raster datasets, and multi-dimensional data. It can be used as a permanent cloud storage space for saving the time series analysis results. We examine the issues associated with running R scripts online: including code validation, saving of outputs, reporting progress, and provenance management. An explicit goal is that the script which is run locally should produce exactly the same results as the script run on the Internet. Our design can be used as a model for other studies that need to run R scripts on the web.

  7. Designing Studies That Would Address the Multilayered Nature of Health Care

    PubMed Central

    Pennell, Michael; Rhoda, Dale; Hade, Erinn M.; Paskett, Electra D.

    2010-01-01

    We review design and analytic methods available for multilevel interventions in cancer research with particular attention to study design, sample size requirements, and potential to provide statistical evidence for causal inference. The most appropriate methods will depend on the stage of development of the research and whether randomization is possible. Early on, fractional factorial designs may be used to screen intervention components, particularly when randomization of individuals is possible. Quasi-experimental designs, including time-series and multiple baseline designs, can be useful once the intervention is designed because they require few sites and can provide the preliminary evidence to plan efficacy studies. In efficacy and effectiveness studies, group-randomized trials are preferred when randomization is possible and regression discontinuity designs are preferred otherwise if assignment based on a quantitative score is possible. Quasi-experimental designs may be used, especially when combined with recent developments in analytic methods to reduce bias in effect estimates. PMID:20386057

  8. [Not Available].

    PubMed

    Paturzo, Marco; Colaceci, Sofia; Clari, Marco; Mottola, Antonella; Alvaro, Rosaria; Vellone, Ercole

    2016-01-01

    . Mixed methods designs: an innovative methodological approach for nursing research. The mixed method research designs (MM) combine qualitative and quantitative approaches in the research process, in a single study or series of studies. Their use can provide a wider understanding of multifaceted phenomena. This article presents a general overview of the structure and design of MM to spread this approach in the Italian nursing research community. The MM designs most commonly used in the nursing field are the convergent parallel design, the sequential explanatory design, the exploratory sequential design and the embedded design. For each method a research example is presented. The use of MM can be an added value to improve clinical practices as, through the integration of qualitative and quantitative methods, researchers can better assess complex phenomena typical of nursing.

  9. 78 FR 11661 - Request for Information: Main Study Design for the National Children's Study

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ....nationalchildrensstudy.gov/research/workshops/Pages/nationalacademyofsciencesworkshop.aspx . DATES: RFI Release Date is...-response relationships, substudies embedded in the Vanguard Study or the Main Study, and formative research... fall of 2012, the NCS held a series of meetings with federal and non-federal statistical sampling...

  10. A Study of the Generalizability of Teacher Change Quasi-Experiments

    ERIC Educational Resources Information Center

    Stringfield, Samuel; Schaffer, Eugene; Devlin-Scherer, Roberta

    2017-01-01

    Quasi-experimental teacher effectiveness studies have indicated that properly designed staff development programs can lead to changes in teacher and student behavior and to gains in student achievement. Those studies involved workshop series led by nationally known scholars. Using instructors from varied backgrounds, the current study examined the…

  11. 75 FR 11574 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... agency's ``Regulatory Guide'' series. This series was developed to describe and make available to the... protection during plant operation and maintenance activities. For plants that have a design basis that... coatings be qualified and capable of surviving a design-basis accident without adversely affecting safety...

  12. 75 FR 53352 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... Guide, DG-1247, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants.'' FOR FURTHER...'s ``Regulatory Guide'' series. This series was developed to describe and make available to the.... The draft regulatory guide (DG), entitled, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear...

  13. Comparison of different synthetic 5-min rainfall time series regarding their suitability for urban drainage modelling

    NASA Astrophysics Data System (ADS)

    van der Heijden, Sven; Callau Poduje, Ana; Müller, Hannes; Shehu, Bora; Haberlandt, Uwe; Lorenz, Manuel; Wagner, Sven; Kunstmann, Harald; Müller, Thomas; Mosthaf, Tobias; Bárdossy, András

    2015-04-01

    For the design and operation of urban drainage systems with numerical simulation models, long, continuous precipitation time series with high temporal resolution are necessary. Suitable observed time series are rare. As a result, intelligent design concepts often use uncertain or unsuitable precipitation data, which renders them uneconomic or unsustainable. An expedient alternative to observed data is the use of long, synthetic rainfall time series as input for the simulation models. Within the project SYNOPSE, several different methods to generate synthetic precipitation data for urban drainage modelling are advanced, tested, and compared. The presented study compares four different approaches of precipitation models regarding their ability to reproduce rainfall and runoff characteristics. These include one parametric stochastic model (alternating renewal approach), one non-parametric stochastic model (resampling approach), one downscaling approach from a regional climate model, and one disaggregation approach based on daily precipitation measurements. All four models produce long precipitation time series with a temporal resolution of five minutes. The synthetic time series are first compared to observed rainfall reference time series. Comparison criteria include event based statistics like mean dry spell and wet spell duration, wet spell amount and intensity, long term means of precipitation sum and number of events, and extreme value distributions for different durations. Then they are compared regarding simulated discharge characteristics using an urban hydrological model on a fictitious sewage network. First results show a principal suitability of all rainfall models but with different strengths and weaknesses regarding the different rainfall and runoff characteristics considered.

  14. Life on Guam: Farm & Garden.

    ERIC Educational Resources Information Center

    Moore, Philip H.

    This unit is a part of a series of materials produced by a project to develop locally applicable class, lab, and field materials in ecology and social studies for Guam junior and senior high school. While the materials were designed for Guam, they can be adapted to other localities. This unit is designed to interest the student in growing plants…

  15. Examination of Assessment Practices for Engineering Design Projects in Secondary Technology Education (Second Article in 3-Part Series)

    ERIC Educational Resources Information Center

    Kelley, Todd R.; Wicklein, Robert C.

    2009-01-01

    Based on the efforts to infuse engineering practices within the technology education curriculum it is appropriate to now investigate how technology education teachers are assessing engineering design activities within their classrooms. This descriptive study drew a full sample of high school technology teachers from the current International…

  16. On Human Communication: A Review, a Survey, and a Criticism.

    ERIC Educational Resources Information Center

    Cherry, Colin

    This book, uniting the material from numerous lectures on communication theory, is designed to serve as the introduction to a series entitled "Studies in Communication," which will appear during the next few years. It is not intended for the expert in each of the many fields related to human communication, but, rather, it is designed for the…

  17. Sweet Grass Elementary School: A Study in Energy Conservation. Energy Conservation: School Design.

    ERIC Educational Resources Information Center

    Edmonton Public Schools (Alberta).

    The results of building a new school in Edmonton (Alberta) in accordance with energy efficient principles are described in this report, the third and last in a series describing three projects utilizing different approaches to energy conservation. The Sweet Grass Elementary School project consisted in designing, building, and monitoring an energy…

  18. Slushie World: An In-Class Access Database Tutorial

    ERIC Educational Resources Information Center

    Wynn, Donald E., Jr.; Pratt, Renée M. E.

    2015-01-01

    The Slushie World case study is designed to teach the basics of Microsoft Access and database management over a series of three 75-minute class sessions. Students are asked to build a basic database to track sales and inventory for a small business. Skills to be learned include table creation, data entry and importing, form and report design,…

  19. Innovations: The Social Consequences of Science and Technology. Final Evaluation Report.

    ERIC Educational Resources Information Center

    Tolman, Richard R.

    The Biological Sciences Curriculum Study designed, developed, and field-tested a series of nine curriculum resource units for a semester program called "Innovations: The Social Consequences of Science and Technology (IST)." The units were designed for use by students and teachers in the 11th and 12th grades and at the junior college…

  20. Settlement Unit. Using Primary Sources in the Classroom.

    ERIC Educational Resources Information Center

    Alabama Dept. of Archives and History, Montgomery.

    This teaching unit, "Settlement Unit,"which focuses on the settlement of Alabama's land, is the second in a series of 10 units about Alabama state history, part of a project designed to help teachers integrate the use of primary source materials into their classrooms. Although the units are designed to augment the study of Alabama, they…

  1. Deep Learning in Distance Education: Are We Achieving the Goal?

    ERIC Educational Resources Information Center

    Shearer, Rick L.; Gregg, Andrea; Joo, K. P.

    2015-01-01

    As educators, one of our goals is to help students arrive at deeper levels of learning. However, how is this accomplished, especially in online courses? This design-based research study explored the concept of deep learning through a series of design changes in a graduate education course. A key question that emerged was through what learning…

  2. Flat-plate photovoltaic array design optimization

    NASA Technical Reports Server (NTRS)

    Ross, R. G., Jr.

    1980-01-01

    An analysis is presented which integrates the results of specific studies in the areas of photovoltaic structural design optimization, optimization of array series/parallel circuit design, thermal design optimization, and optimization of environmental protection features. The analysis is based on minimizing the total photovoltaic system life-cycle energy cost including repair and replacement of failed cells and modules. This approach is shown to be a useful technique for array optimization, particularly when time-dependent parameters such as array degradation and maintenance are involved.

  3. Assessment of an Onboard EO Sensor to Enable Detect-and-Sense Capability for UAVs Operating in a Cluttered Environment

    DTIC Science & Technology

    2017-09-01

    via visual sensors onboard the UAV. Both the hardware and software architecture design are discussed at length. Then, a series of tests that were...visual sensors onboard the UAV. Both the hardware and software architecture design are discussed at length. Then, a series of tests that were conducted...and representing the change in time . (1) Horn and Schunck (1981) further simplified this equation by taking the Taylor series

  4. Evaluating efficiency and statistical power of self-controlled case series and self-controlled risk interval designs in vaccine safety.

    PubMed

    Li, Rongxia; Stewart, Brock; Weintraub, Eric

    2016-01-01

    The self-controlled case series (SCCS) and self-controlled risk interval (SCRI) designs have recently become widely used in the field of post-licensure vaccine safety monitoring to detect potential elevated risks of adverse events following vaccinations. The SCRI design can be viewed as a subset of the SCCS method in that a reduced comparison time window is used for the analysis. Compared to the SCCS method, the SCRI design has less statistical power due to fewer events occurring in the shorter control interval. In this study, we derived the asymptotic relative efficiency (ARE) between these two methods to quantify this loss in power in the SCRI design. The equation is formulated as [Formula: see text] (a: control window-length ratio between SCRI and SCCS designs; b: ratio of risk window length and control window length in the SCCS design; and [Formula: see text]: relative risk of exposed window to control window). According to this equation, the relative efficiency declines as the ratio of control-period length between SCRI and SCCS methods decreases, or with an increase in the relative risk [Formula: see text]. We provide an example utilizing data from the Vaccine Safety Datalink (VSD) to study the potential elevated risk of febrile seizure following seasonal influenza vaccine in the 2010-2011 season.

  5. Adding Design Elements to Improve Time Series Designs: No Child Left behind as an Example of Causal Pattern-Matching

    ERIC Educational Resources Information Center

    Wong, Manyee; Cook, Thomas D.; Steiner, Peter M.

    2015-01-01

    Some form of a short interrupted time series (ITS) is often used to evaluate state and national programs. An ITS design with a single treatment group assumes that the pretest functional form can be validly estimated and extrapolated into the postintervention period where it provides a valid counterfactual. This assumption is problematic. Ambiguous…

  6. The Future of STEM Curriculum and Instructional Design: A Research and Development Agenda for Learning Designers. Report of a Workshop Series

    ERIC Educational Resources Information Center

    Center for the Study of Mathematics Curriculum, 2012

    2012-01-01

    In 2009-10 a series of Workshops was organized to focus on STEM (science, technology, engineering, and mathematics) learning design for young students and adolescents. The objective was to provide visionary leadership to the education community by: (a) identifying and analyzing the needs and opportunities for future STEM curriculum development and…

  7. 78 FR 15978 - Blackstone Alternative Investment Funds, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... of a Subadvised Series' assets, and (c) implement procedures reasonably designed to ensure that Sub... open-end management investment company. The Trust may offer one or more series of shares (each, a ``Series'') with its own distinct investment objectives, policies and restrictions.\\1\\ Each Series has, or...

  8. Technology Utilization Conference Series, volume 1

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The design, development, and results of a series of technology utilization conferences are presented. The conference series represents the development of a viable and successful means of encouraging the transfer of technology to the minority business community.

  9. Trends in Elevated Triglyceride in Adults: United States, 2001-2012

    MedlinePlus

    ... All variance estimates accounted for the complex survey design using Taylor series linearization ( 10 ). Percentage estimates for the total adult ... al. National Health and Nutrition Examination Survey: Sample design, 2007–2010. ... KM. Taylor series methods. In: Introduction to variance estimation. 2nd ed. ...

  10. 76 FR 10917 - Draft Regulatory Guide: Issuance, Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-28

    ... in the agency's ``Regulatory Guide'' series. This series was developed to describe and make available... connection assemblies can perform their safety functions during and after a design-basis event. Title 10 of... Reprocessing Plants,'' Criterion III, ``Design Control,'' requires, in part, that test programs used to verify...

  11. [Diversity and frequency of scientific research design and statistical methods in the "Arquivos Brasileiros de Oftalmologia": a systematic review of the "Arquivos Brasileiros de Oftalmologia"--1993-2002].

    PubMed

    Crosta, Fernando; Nishiwaki-Dantas, Maria Cristina; Silvino, Wilmar; Dantas, Paulo Elias Correa

    2005-01-01

    To verify the frequency of study design, applied statistical analysis and approval by institutional review offices (Ethics Committee) of articles published in the "Arquivos Brasileiros de Oftalmologia" during a 10-year interval, with later comparative and critical analysis by some of the main international journals in the field of Ophthalmology. Systematic review without metanalysis was performed. Scientific papers published in the "Arquivos Brasileiros de Oftalmologia" between January 1993 and December 2002 were reviewed by two independent reviewers and classified according to the applied study design, statistical analysis and approval by the institutional review offices. To categorize those variables, a descriptive statistical analysis was used. After applying inclusion and exclusion criteria, 584 articles for evaluation of statistical analysis and, 725 articles for evaluation of study design were reviewed. Contingency table (23.10%) was the most frequently applied statistical method, followed by non-parametric tests (18.19%), Student's t test (12.65%), central tendency measures (10.60%) and analysis of variance (9.81%). Of 584 reviewed articles, 291 (49.82%) presented no statistical analysis. Observational case series (26.48%) was the most frequently used type of study design, followed by interventional case series (18.48%), observational case description (13.37%), non-random clinical study (8.96%) and experimental study (8.55%). We found a higher frequency of observational clinical studies, lack of statistical analysis in almost half of the published papers. Increase in studies with approval by institutional review Ethics Committee was noted since it became mandatory in 1996.

  12. Usability engineering for augmented reality: employing user-based studies to inform design.

    PubMed

    Gabbard, Joseph L; Swan, J Edward

    2008-01-01

    A major challenge, and thus opportunity, in the field of human-computer interaction and specifically usability engineering is designing effective user interfaces for emerging technologies that have no established design guidelines or interaction metaphors or introduce completely new ways for users to perceive and interact with technology and the world around them. Clearly, augmented reality is one such emerging technology. We propose a usability engineering approach that employs user-based studies to inform design, by iteratively inserting a series of user-based studies into a traditional usability engineering lifecycle to better inform initial user interface designs. We present an exemplar user-based study conducted to gain insight into how users perceive text in outdoor augmented reality settings and to derive implications for design in outdoor augmented reality. We also describe lessons learned from our experiences conducting user-based studies as part of the design process.

  13. On the equivalence of case-crossover and time series methods in environmental epidemiology.

    PubMed

    Lu, Yun; Zeger, Scott L

    2007-04-01

    The case-crossover design was introduced in epidemiology 15 years ago as a method for studying the effects of a risk factor on a health event using only cases. The idea is to compare a case's exposure immediately prior to or during the case-defining event with that same person's exposure at otherwise similar "reference" times. An alternative approach to the analysis of daily exposure and case-only data is time series analysis. Here, log-linear regression models express the expected total number of events on each day as a function of the exposure level and potential confounding variables. In time series analyses of air pollution, smooth functions of time and weather are the main confounders. Time series and case-crossover methods are often viewed as competing methods. In this paper, we show that case-crossover using conditional logistic regression is a special case of time series analysis when there is a common exposure such as in air pollution studies. This equivalence provides computational convenience for case-crossover analyses and a better understanding of time series models. Time series log-linear regression accounts for overdispersion of the Poisson variance, while case-crossover analyses typically do not. This equivalence also permits model checking for case-crossover data using standard log-linear model diagnostics.

  14. Non-parametric characterization of long-term rainfall time series

    NASA Astrophysics Data System (ADS)

    Tiwari, Harinarayan; Pandey, Brij Kishor

    2018-03-01

    The statistical study of rainfall time series is one of the approaches for efficient hydrological system design. Identifying, and characterizing long-term rainfall time series could aid in improving hydrological systems forecasting. In the present study, eventual statistics was applied for the long-term (1851-2006) rainfall time series under seven meteorological regions of India. Linear trend analysis was carried out using Mann-Kendall test for the observed rainfall series. The observed trend using the above-mentioned approach has been ascertained using the innovative trend analysis method. Innovative trend analysis has been found to be a strong tool to detect the general trend of rainfall time series. Sequential Mann-Kendall test has also been carried out to examine nonlinear trends of the series. The partial sum of cumulative deviation test is also found to be suitable to detect the nonlinear trend. Innovative trend analysis, sequential Mann-Kendall test and partial cumulative deviation test have potential to detect the general as well as nonlinear trend for the rainfall time series. Annual rainfall analysis suggests that the maximum changes in mean rainfall is 11.53% for West Peninsular India, whereas the maximum fall in mean rainfall is 7.8% for the North Mountainous Indian region. The innovative trend analysis method is also capable of finding the number of change point available in the time series. Additionally, we have performed von Neumann ratio test and cumulative deviation test to estimate the departure from homogeneity. Singular spectrum analysis has been applied in this study to evaluate the order of departure from homogeneity in the rainfall time series. Monsoon season (JS) of North Mountainous India and West Peninsular India zones has higher departure from homogeneity and singular spectrum analysis shows the results to be in coherence with the same.

  15. Experimental study of a valveless pulse detonation rocket engine using nontoxic hypergolic propellants

    NASA Astrophysics Data System (ADS)

    Kan, Brandon K.

    A pulsed detonation rocket engine concept was explored through the use of hypergolic propellants in a fuel-centered pintle injector combustor. The combustor design yielded a simple open ended chamber with a pintle type injection element and pressure instrumentation. High-frequency pressure measurements from the first test series showed the presence of large pressure oscillations in excess of 2000 psia at frequencies between 400-600 hz during operation. High-speed video confirmed the high-frequency pulsed behavior and large amounts of after burning. Damaged hardware and instrumentation failure limited the amount of data gathered in the first test series, but the experiments met original test objectives of producing large over-pressures in an open chamber. A second test series proceeded by replacing hardware and instrumentation, and new data showed that pulsed events produced under expanded exhaust prior to pulsing, peak pressures around 8000 psi, and operating frequencies between 400-800 hz. Later hot-fires produced no pulsed behavior despite undamaged hardware. The research succeeded in producing pulsed combustion behavior using hypergolic fuels in a pintle injector setup and provided insights into design concepts that would assist future injector designs and experimental test setups.

  16. Interspecific competition in plants: how well do current methods answer fundamental questions?

    PubMed

    Connolly, J; Wayne, P; Bazzaz, F A

    2001-02-01

    Accurately quantifying and interpreting the processes and outcomes of competition among plants is essential for evaluating theories of plant community organization and evolution. We argue that many current experimental approaches to quantifying competitive interactions introduce size bias, which may significantly impact the quantitative and qualitative conclusions drawn from studies. Size bias generally arises when estimates of competitive ability are erroneously influenced by the initial size of competing individuals. We employ a series of quantitative thought experiments to demonstrate the potential for size bias in analysis of four traditional experimental designs (pairwise, replacement series, additive series, and response surfaces) either when only final measurements are available or when both initial and final measurements are collected. We distinguish three questions relevant to describing competitive interactions: Which species dominates? Which species gains? and How do species affect each other? The choice of experimental design and measurements greatly influences the scope of inference permitted. Conditions under which the latter two questions can give biased information are tabulated. We outline a new approach to characterizing competition that avoids size bias and that improves the concordance between research question and experimental design. The implications of the choice of size metrics used to quantify both the initial state and the responses of elements in interspecific mixtures are discussed. The relevance of size bias in competition studies with organisms other than plants is also discussed.

  17. Economic Organization Module. Test Booklet. Test Items for Booklets 1, 2, 3=Libro de prueba. Modulo de organizacion economica. Itemes de prueba para los libros 1, 2, 3.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and designed to help students understand some major human problems and make sound, responsive decisions to improve…

  18. Environment Module. Test Booklet. Test Items for Booklets 1, 2, 3, 4=Libro de prueba. Modulo del medio ambiente. Itemes de prueba para los libros 1, 2, 3, 4.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and are designed to help students understand some major human problems and make sound, responsive decisions to…

  19. Less and Less for More and More. Economic Organization Booklet 1. Teacher's Edition=Menos y menos por mas y mas. Organizacion economica libro 1. Manual para El Maestro.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and are designed to help students understand some major human problems and make sound, responsive decisions to…

  20. Model-Based Design of Long-Distance Tracer Transport Experiments in Plants.

    PubMed

    Bühler, Jonas; von Lieres, Eric; Huber, Gregor J

    2018-01-01

    Studies of long-distance transport of tracer isotopes in plants offer a high potential for functional phenotyping, but so far measurement time is a bottleneck because continuous time series of at least 1 h are required to obtain reliable estimates of transport properties. Hence, usual throughput values are between 0.5 and 1 samples h -1 . Here, we propose to increase sample throughput by introducing temporal gaps in the data acquisition of each plant sample and measuring multiple plants one after each other in a rotating scheme. In contrast to common time series analysis methods, mechanistic tracer transport models allow the analysis of interrupted time series. The uncertainties of the model parameter estimates are used as a measure of how much information was lost compared to complete time series. A case study was set up to systematically investigate different experimental schedules for different throughput scenarios ranging from 1 to 12 samples h -1 . Selected designs with only a small amount of data points were found to be sufficient for an adequate parameter estimation, implying that the presented approach enables a substantial increase of sample throughput. The presented general framework for automated generation and evaluation of experimental schedules allows the determination of a maximal sample throughput and the respective optimal measurement schedule depending on the required statistical reliability of data acquired by future experiments.

  1. Decoding Dynamic Brain Patterns from Evoked Responses: A Tutorial on Multivariate Pattern Analysis Applied to Time Series Neuroimaging Data.

    PubMed

    Grootswagers, Tijl; Wardle, Susan G; Carlson, Thomas A

    2017-04-01

    Multivariate pattern analysis (MVPA) or brain decoding methods have become standard practice in analyzing fMRI data. Although decoding methods have been extensively applied in brain-computer interfaces, these methods have only recently been applied to time series neuroimaging data such as MEG and EEG to address experimental questions in cognitive neuroscience. In a tutorial style review, we describe a broad set of options to inform future time series decoding studies from a cognitive neuroscience perspective. Using example MEG data, we illustrate the effects that different options in the decoding analysis pipeline can have on experimental results where the aim is to "decode" different perceptual stimuli or cognitive states over time from dynamic brain activation patterns. We show that decisions made at both preprocessing (e.g., dimensionality reduction, subsampling, trial averaging) and decoding (e.g., classifier selection, cross-validation design) stages of the analysis can significantly affect the results. In addition to standard decoding, we describe extensions to MVPA for time-varying neuroimaging data including representational similarity analysis, temporal generalization, and the interpretation of classifier weight maps. Finally, we outline important caveats in the design and interpretation of time series decoding experiments.

  2. 14 CFR 129.115 - Limit of validity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... certificate or a later design change. This section also applies to foreign air carriers or foreign persons... A300-600 Series 30 30,000 FC/67,500 FH A310-200 Series 30 40,000 FC/60,000 FH A310-300 Series 30 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  3. 14 CFR 129.115 - Limit of validity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... certificate or a later design change. This section also applies to foreign air carriers or foreign persons... A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH A310-300 Series 60 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  4. 14 CFR 129.115 - Limit of validity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... certificate or a later design change. This section also applies to foreign air carriers or foreign persons... A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH A310-300 Series 60 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  5. 14 CFR 129.115 - Limit of validity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... certificate or a later design change. This section also applies to foreign air carriers or foreign persons... A300-600 Series 30 30,000 FC/67,500 FH A310-200 Series 30 40,000 FC/60,000 FH A310-300 Series 30 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  6. 75 FR 81560 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ... associated risk factors. As part of an ongoing series of NAHMS studies on the U.S. livestock population... study is designed to collect information on operations with total annual sales between $10,000 and $250... number. Animal and Plant Health Inspection Service Title: Small-Scale Livestock Operations 2011 Study...

  7. 40 CFR 94.8 - Exhaust emission standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...)(i) of this section. (f) The following define the requirements for low-emitting Blue Sky Series engines: (1) Voluntary standards. (i) Category 1 and Category 2 engines may be designated “Blue Sky Series... may be designated “Blue Sky Series” engines by meeting these voluntary standards that would apply to...

  8. Implementing Collaborative Design in the Next Series of eLearning Platforms

    ERIC Educational Resources Information Center

    Kropf, Dorothy

    2013-01-01

    Collaborative design empowers learning management system (LMS) providers and end users (online students) to develop a vibrant teaching and learning community. Successful periodic collaborations utilizing collaborative web tools between these two pivotal groups can produce the next series of eLearning platforms that are fertile grounds for…

  9. 75 FR 11184 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... ROPS. To overcome these barriers, NIOSH designed a prototype of a cost-effective roll over protective... installation complexity is significantly reduced. NIOSH has CROPS prototype designs for five tractors: Ford 3000 series, Ford 4000 series, Ford 8N, Ford 4600 and Massey-Ferguson 135. However, this technology has...

  10. Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists.

    PubMed

    Burkholder, Timothy P; Cunningham, Brian E; Clayton, Joshua R; Lander, Peter A; Brown, Matthew L; Doti, Robert A; Durst, Gregory L; Montrose-Rafizadeh, Chahrzad; King, Constance; Osborne, Harold E; Amos, Robert M; Zink, Richard W; Stramm, Lawrence E; Burris, Thomas P; Cardona, Guemalli; Konkol, Debra L; Reidy, Charles; Christe, Michael E; Genin, Michael J

    2015-04-01

    The design, synthesis, and structure activity relationships for a novel series of indoles as potent, selective, thyroid hormone receptor β (TRβ) agonists is described. Compounds with >50× binding selectivity for TRβ over TRα were generated and evaluation of compound 1c from this series in a model of dyslipidemia demonstrated positive effects on plasma lipid endpoints in vivo. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Filter-based multiscale entropy analysis of complex physiological time series.

    PubMed

    Xu, Yuesheng; Zhao, Liang

    2013-08-01

    Multiscale entropy (MSE) has been widely and successfully used in analyzing the complexity of physiological time series. We reinterpret the averaging process in MSE as filtering a time series by a filter of a piecewise constant type. From this viewpoint, we introduce filter-based multiscale entropy (FME), which filters a time series to generate multiple frequency components, and then we compute the blockwise entropy of the resulting components. By choosing filters adapted to the feature of a given time series, FME is able to better capture its multiscale information and to provide more flexibility for studying its complexity. Motivated by the heart rate turbulence theory, which suggests that the human heartbeat interval time series can be described in piecewise linear patterns, we propose piecewise linear filter multiscale entropy (PLFME) for the complexity analysis of the time series. Numerical results from PLFME are more robust to data of various lengths than those from MSE. The numerical performance of the adaptive piecewise constant filter multiscale entropy without prior information is comparable to that of PLFME, whose design takes prior information into account.

  12. Evaluation of the best fit distribution for partial duration series of daily rainfall in Madinah, western Saudi Arabia

    NASA Astrophysics Data System (ADS)

    Alahmadi, F.; Rahman, N. A.; Abdulrazzak, M.

    2014-09-01

    Rainfall frequency analysis is an essential tool for the design of water related infrastructure. It can be used to predict future flood magnitudes for a given magnitude and frequency of extreme rainfall events. This study analyses the application of rainfall partial duration series (PDS) in the vast growing urban Madinah city located in the western part of Saudi Arabia. Different statistical distributions were applied (i.e. Normal, Log Normal, Extreme Value type I, Generalized Extreme Value, Pearson Type III, Log Pearson Type III) and their distribution parameters were estimated using L-moments methods. Also, different selection criteria models are applied, e.g. Akaike Information Criterion (AIC), Corrected Akaike Information Criterion (AICc), Bayesian Information Criterion (BIC) and Anderson-Darling Criterion (ADC). The analysis indicated the advantage of Generalized Extreme Value as the best fit statistical distribution for Madinah partial duration daily rainfall series. The outcome of such an evaluation can contribute toward better design criteria for flood management, especially flood protection measures.

  13. 77 FR 40889 - Proposed Data Collections Submitted for Public Comment and Recommendations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... evaluation study will be conducted using a group-randomized controlled trial multi-time series design. Four... their time. Estimated Annualized Burden Hours Number of Average burden Respondents Number of responses...

  14. Control of Echolalic Speech in Psychotic Children

    ERIC Educational Resources Information Center

    Carr, Edward G.; And Others

    1975-01-01

    Immediate echolalia (repeating what someone has just said) was studied in a series of replicated single-subject designs across six schizophrenic and five normal children (all ranging in age from 2 to 15 years). (Author/SBH)

  15. Series hybrid vehicles and optimized hydrogen engine design

    NASA Astrophysics Data System (ADS)

    Smith, J. R.; Aceves, S.; Vanblarigan, P.

    1995-05-01

    Lawrence Livermore, Sandia Livermore and Los Alamos National Laboratories have a joint project to develop an optimized hydrogen fueled engine for series hybrid automobiles. The major divisions of responsibility are: system analysis, engine design and kinetics modeling by LLNL; performance and emission testing, and friction reduction by SNL; computational fluid mechanics and combustion modeling by LANL. This project is a component of the Department of Energy, Office of Utility Technology, National Hydrogen Program. We report here on the progress on system analysis and preliminary engine testing. We have done system studies of series hybrid automobiles that approach the PNGV design goal of 34 km/liter (80 mpg), for 384 km (240 mi) and 608 km (380 mi) ranges. Our results indicate that such a vehicle appears feasible using an optimized hydrogen engine. The impact of various on-board storage options on fuel economy are evaluated. Experiments with an available engine at the Sandia Combustion Research Facility demonstrated NO(x) emissions of 10 to 20 ppm at an equivalence ratio of 0.4, rising to about 500 ppm at 0.5 equivalence ratio using neat hydrogen. Hybrid vehicle simulation studies indicate that exhaust NO(x) concentrations must be less than 180 ppm to meet the 0.2 g/mile California Air Resources Board ULEV or Federal Tier-2 emissions regulations. We have designed and fabricated a first generation optimized hydrogen engine head for use on an existing single cylinder Onan engine. This head currently features 14.8:1 compression ratio, dual ignition, water cooling, two valves and open quiescent combustion chamber to minimize heat transfer losses.

  16. Secondary School Mathematics Curriculum Improvement Study Information Bulletin 7.

    ERIC Educational Resources Information Center

    Secondary School Mathematics Curriculum Improvement Study, New York, NY.

    The background, objectives, and design of Secondary School Mathematics Curriculum Improvement Study (SSMCIS) are summarized. Details are given of the content of the text series, "Unified Modern Mathematics," in the areas of algebra, geometry, linear algebra, probability and statistics, analysis (calculus), logic, and computer…

  17. Ohio Studies: Minimum Standards Leadership Series 1985.

    ERIC Educational Resources Information Center

    Ohio State Dept. of Education, Columbus. Div. of Elementary and Secondary Education.

    This monograph is designed to provide materials, ideas, and strategies for school districts and teachers to broaden and expand the standards and requirements of Ohio studies. Section 1, "Introduction" provides an overview of the monograph. Section 2, "Organizing for Instruction" gives several alternative approaches to designing…

  18. 78 FR 60344 - Forethought Variable Insurance Trust, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... designed to ensure that the Sub-Advisers comply with a Sub- Advised Series' investment objectives, policies...-end management investment company. The Trust may offer one or more series of shares (each, a ``Series... an investment adviser under the Investment Advisers Act of 1940 (``Advisers Act''). Each Series will...

  19. The Lifting Body Legacy...X-33

    NASA Technical Reports Server (NTRS)

    Barret, Chris

    1999-01-01

    NASA has a technology program in place to enable the development of a next generation Reusable Launch Vehicle that will carry our future payloads into orbit at a much-reduced cost. The VentureStar, Lifting Body (LB) flight vehicle, is one of the potential reusable launch vehicle configurations being studied. A LB vehicle has no wings and derives its lift solely from the shape of its body, and has the unique advantages of superior volumetric efficiency, better aerodynamic efficiency at high angles-of-attack and hypersonic speeds, and reduced thermal protection system weight. Classically, in a ballistic vehicle, drag has been employed to control the level of deceleration in reentry. In the LB, lift enables the vehicle to decelerate at higher altitudes for the same velocity and defines the reentry corridor which includes a greater cross range. This paper outlines the flight stability and control aspects of our LB heritage which was utilized in the design of the VentureStar LB and its test version, the X-33. NASA and the U.S. Air Force have a rich heritage of LB vehicle design and flight experience. In the initial LB Program, eight LB's were built and over 225 LB test flights were conducted through 1975. Three LB series were most significant in the advancement of today's LB technolocy: the M2-F; the HL-10; and the X-24 series. The M2-F series was designed by NASA Ames Research Center, the HL-10 series by NASA Langley Research Center, and the X-24 series by the U. S. Air Force. LB vehicles are alive again today with the X- 33, X-38, and VentureStar.

  20. Investigation of naphthofuran moiety as potential dual inhibitor against BACE-1 and GSK-3β: molecular dynamics simulations, binding energy, and network analysis to identify first-in-class dual inhibitors against Alzheimer's disease.

    PubMed

    Kumar, Akhil; Srivastava, Gaurava; Srivastava, Swati; Verma, Seema; Negi, Arvind S; Sharma, Ashok

    2017-08-01

    BACE-1 and GSK-3β are potential therapeutic drug targets for Alzheimer's disease. Recently, both the targets received attention for designing dual inhibitors for Alzheimer's disease. Until now, only two-scaffold triazinone and curcumin have been reported as BACE-1 and GSK-3β dual inhibitors. Docking, molecular dynamics, clustering, binding energy, and network analysis of triazinone derivatives with BACE-1 and GSK-3β was performed to get molecular insight into the first reported dual inhibitor. Further, we designed and evaluated a naphthofuran series for its ability to inhibit BACE-1 and GSK-3β with the computational approaches. Docking study of naphthofuran series showed a good binding affinity towards both the targets. Molecular dynamics, binding energy, and network analysis were performed to compare their binding with the targets and amino acids responsible for binding. Naphthofuran series derivatives showed good interaction within the active site residues of both of the targets. Hydrogen bond occupancy and binding energy suggested strong binding with the targets. Dual-inhibitor binding was mostly governed by the hydrophobic interactions for both of the targets. Per residue energy decomposition and network analysis identified the key residues involved in the binding and inhibiting BACE-1 and GSK-3β. The results indicated that naphthofuran series derivative 11 may be a promising first-in-class dual inhibitor against BACE-1 and GSK-3β. This naphthofuran series may be further explored to design better dual inhibitors. Graphical abstract Naphthofuran derivative as a dual inhibitor for BACE-1 and GSK-3β.

  1. Space Station Freedom coupling tasks: An evaluation of their telerobotic and EVA compatibility

    NASA Technical Reports Server (NTRS)

    Sampaio, Carlos E.; Bierschwale, John M.; Fleming, Terence F.; Stuart, Mark A.

    1993-01-01

    Of the couplings included in this study, several design components were found to be of interest. With respect to the operation of the couplings, the various concepts resulted in differing reactions from the four subjects who participated in this study. The purpose of this study was not to conceive the final coupling design. Rather, it was intended as a step along an interactive process. The newly modified coupling will be included in a series of further controlled, as well as subjective, evaluations. This part of the ongoing work in the Remote Operator Interaction Laboratory (ROIL) designed to enhance the overall interface by improving design at both the teleoperator and telerobot ends of the system.

  2. International Evaluation Studies of Second Step, a Primary Prevention Programme: A Review

    ERIC Educational Resources Information Center

    Schick, Andreas; Cierpka, Manfred

    2013-01-01

    Second Step is a social-emotional, skill-based, violence-prevention programme, which has been adapted for several European countries. The various versions of the programme (for kindergarten/preschool, elementary school, middle school) have been evaluated in a series of research studies. The outcomes and study designs of these studies are reported…

  3. The Nevada Study on The Holocaust.

    ERIC Educational Resources Information Center

    Crawford, Barbara; Metcalf, Sandra

    This study series on the Holocaust consists of four units designed for middle school/junior high and senior high students in United States and world history classes. The units may be self-contained or integrated into previous units of study. A 45-minute color video "Nevada Study on The Holocaust" accompanies this guide. The middle school…

  4. Women's Studies: A Resource Guide for Teachers.

    ERIC Educational Resources Information Center

    British Columbia Dept. of Education, Victoria.

    Designed to help secondary teachers in British Columbia (Canada) supplement the curriculum, the guide contains a series of units focusing on women's studies. The units can be integrated into English, social studies, and guidance courses or used as a resource for the development of a women's studies course. Topics covered are reflected in the unit…

  5. 41 CFR 60-3.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... likely to affect validity differences; or that these factors are included in the design of the study and... construct validity is both an extensive and arduous effort involving a series of research studies, which... validity studies. 60-3.14 Section 60-3.14 Public Contracts and Property Management Other Provisions...

  6. 41 CFR 60-3.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... likely to affect validity differences; or that these factors are included in the design of the study and... construct validity is both an extensive and arduous effort involving a series of research studies, which... validity studies. 60-3.14 Section 60-3.14 Public Contracts and Property Management Other Provisions...

  7. 41 CFR 60-3.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... likely to affect validity differences; or that these factors are included in the design of the study and... construct validity is both an extensive and arduous effort involving a series of research studies, which... validity studies. 60-3.14 Section 60-3.14 Public Contracts and Property Management Other Provisions...

  8. 41 CFR 60-3.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... likely to affect validity differences; or that these factors are included in the design of the study and... construct validity is both an extensive and arduous effort involving a series of research studies, which... validity studies. 60-3.14 Section 60-3.14 Public Contracts and Property Management Other Provisions...

  9. 41 CFR 60-3.14 - Technical standards for validity studies.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... likely to affect validity differences; or that these factors are included in the design of the study and... construct validity is both an extensive and arduous effort involving a series of research studies, which... validity studies. 60-3.14 Section 60-3.14 Public Contracts and Property Management Other Provisions...

  10. Designing and Evaluating an Interprofessional Experiential Course Series Involving Medical and Pharmacy Students

    PubMed Central

    Dueñas, Gladys G.; Zanoni, Aileen; Grover, Anisha B.

    2016-01-01

    Objective. To prepare first-year and second-year pharmacy and medical students to build effective collaborative health care teams by participating in an interprofessional experiential 6-semester course series. Design. An interprofessional experiential course series was designed using a variety of teaching methods to achieve both interprofessional and experiential learning outcomes. A standardized objective behavioral assessment was developed to measure team performance of interprofessional communication and teamwork. In addition, student perceptions were measured using a validated instrument. Assessment. A majority of teams demonstrated appropriate competence with respect to interprofessional communication and teamwork. Additionally, a majority of students expressed positive perceptions of interprofessional collaboration with respect to teamwork, roles and responsibilities, and patient outcomes. Conclusion. An interprofessional experiential course series can be successfully implemented to achieve both interprofessional and experiential learning outcomes. Highly collaborative teams and positive student perceptions provide evidence of achievement of interprofessional education learning outcomes. PMID:27402988

  11. Getting Down to Business: Software Design Company, Module 20. [Student Guide]. Entrepreneurship Training Components.

    ERIC Educational Resources Information Center

    Shapiro, Norma

    This module on owning and operating a software design company is one of 36 in a series on entrepreneurship. The introduction tells the student what topics will be covered and suggests other modules to read in related occupations. Each unit includes student goals, a case study, and a discussion of the unit subject matter. Learning activities are…

  12. The Effects of Multimedia Learning on Thai Primary Pupils' Achievement in Size and Depth of Vocabulary Knowledge

    ERIC Educational Resources Information Center

    Jingjit, Mathukorn

    2015-01-01

    This study aims to obtain more insight regarding the effect of multimedia learning on third grade of Thai primary pupils' achievement in Size and Depth Vocabulary of English. A quasi-experiment is applied using "one group pretest-posttest design" combined with "time series design," as well as data triangulation. The sample…

  13. Design and implementation of monitoring and evaluation of healthcare organization management

    NASA Astrophysics Data System (ADS)

    Charalampos, Platis; Emmanouil, Zoulias; Dimitrios, Iracleous; Lappa, Evaggelia

    2017-09-01

    The management of a healthcare organization is monitored using a suitably designed questionnaire to 271 nurses operating in Greek hospital. The data are fed to an automatic data mining system to obtain a suitable series of models to analyse, visualise and study the obtained information. Hidden patterns, correlations and interdependencies are investigated and the results are analytically presented.

  14. Using Material Authenticity in the Saudi English Textbook Design: A Content Analysis from the Viewpoint of EFL Teachers

    ERIC Educational Resources Information Center

    Alshumaimeri, Yousif A.; Alzyadi, Maha S.

    2015-01-01

    This study attempts to identify the extent of using authentic materials in the new series of secondary English textbooks ("Flying High for Saudi Arabia") used currently in Saudi schools. Therefore, a content analysis instrument has been designed to analyze the first secondary English textbook. The instrument has been distributed on 112…

  15. Effects of Automated Tier 2 Storybook Intervention on Vocabulary and Comprehension Learning in Preschool Children with Limited Oral Language Skills

    ERIC Educational Resources Information Center

    Kelley, Elizabeth Spencer; Goldstein, Howard; Spencer, Trina D.; Sherman, Amber

    2015-01-01

    This early efficacy study examined the effects of an automated storybook intervention designed to promote school readiness among at-risk prekindergarten children. Story Friends is a small-group intervention in which vocabulary and question-answering lessons are embedded in a series of storybooks.A randomized group design with an embedded…

  16. Jomeokee Geology. Pilot Mountain State Park: An Environmental Education Learning Experience Designed for Grades 9-12.

    ERIC Educational Resources Information Center

    Smith, Michael W.

    This activity packet provides educators with a series of hands-on classroom and outdoor education activities for grades 9-12 that focus on geology using the Pilot Mountain State Park. The packet was designed to meet established curriculum objectives of the North Carolina Department of Public Instruction's Standard Course of Study. Three types of…

  17. Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors.

    PubMed

    Ma, Yuchi; Sun, Guangqiang; Chen, Danqi; Peng, Xia; Chen, Yue-Lei; Su, Yi; Ji, Yinchun; Liang, Jin; Wang, Xin; Chen, Lin; Ding, Jian; Xiong, Bing; Ai, Jing; Geng, Meiyu; Shen, Jingkang

    2015-03-12

    c-Met has emerged as an attractive target for targeted cancer therapy because of its abnormal activation in many cancer cells. To identify high potent and selective c-Met inhibitors, we started with profiling the potency and in vitro metabolic stability of a reported hit 7. By rational design, a novel sulfonylpyrazolo[4,3-b]pyridine 9 with improved DMPK properties was discovered. Further elaboration of π-π stacking interactions and solvent accessible polar moieties led to a series of highly potent and selective type I c-Met inhibitors. On the basis of in vitro and in vivo pharmacological and pharmacokinetics studies, compound 46 was selected as a preclinical candidate for further anticancer drug development.

  18. Making intelligent systems team players: Additional case studies

    NASA Technical Reports Server (NTRS)

    Malin, Jane T.; Schreckenghost, Debra L.; Rhoads, Ron W.

    1993-01-01

    Observations from a case study of intelligent systems are reported as part of a multi-year interdisciplinary effort to provide guidance and assistance for designers of intelligent systems and their user interfaces. A series of studies were conducted to investigate issues in designing intelligent fault management systems in aerospace applications for effective human-computer interaction. The results of the initial study are documented in two NASA technical memoranda: TM 104738 Making Intelligent Systems Team Players: Case Studies and Design Issues, Volumes 1 and 2; and TM 104751, Making Intelligent Systems Team Players: Overview for Designers. The objective of this additional study was to broaden the investigation of human-computer interaction design issues beyond the focus on monitoring and fault detection in the initial study. The results of this second study are documented which is intended as a supplement to the original design guidance documents. These results should be of interest to designers of intelligent systems for use in real-time operations, and to researchers in the areas of human-computer interaction and artificial intelligence.

  19. 14 CFR 121.1115 - Limit of validity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... weight is a result of an original type certificate or a later design change. This section also applies to... A300-600 Series 30 30,000 FC/67,500 FH A310-200 Series 30 40,000 FC/60,000 FH A310-300 Series 30 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  20. 14 CFR 121.1115 - Limit of validity.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... weight is a result of an original type certificate or a later design change. This section also applies to... A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH A310-300 Series 60 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  1. 14 CFR 121.1115 - Limit of validity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... weight is a result of an original type certificate or a later design change. This section also applies to... A300-600 Series 30 30,000 FC/67,500 FH A310-200 Series 30 40,000 FC/60,000 FH A310-300 Series 30 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  2. 14 CFR 121.1115 - Limit of validity.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... weight is a result of an original type certificate or a later design change. This section also applies to... A300-600 Series 60 30,000 FC/67,500 FH A310-200 Series 60 40,000 FC/60,000 FH A310-300 Series 60 35,000 FC/60,000 FH A318 Series 60 48,000 FC/60,000 FH A319 Series 60 48,000 FC/60,000 FH A320-100 Series 60...

  3. Design and Development of a Series Switch for High Voltage in RF Heating

    NASA Astrophysics Data System (ADS)

    Patel, Himanshu K.; Shah, Deep; Thacker, Mauli; Shah, Atman

    2013-02-01

    Plasma is the fourth state of matter. To sustain plasma in its ionic form very high temperature is essential. RF heating systems are used to provide the required temperature. Arching phenomenon in these systems can cause enormous damage to the RF tube. Heavy current flows across the anode-cathode junction, which need to be suppressed in minimal time for its protection. Fast-switching circuit breakers are used to cut-off the load from the supply in cases of arching. The crowbar interrupts the connection between the high voltage power supply (HVPS) and the RF tube for a temporary period between which the series switch has to open. The crowbar shunts the current across the load but in the process leads to short circuiting the HVPS. Thus, to protect the load as well as the HVPS a series switch is necessary. This paper presents the design and development of high voltage Series Switch for the high power switching applications. Fiber optic based Optimum triggering scheme is designed and tested to restrict the time delay well within the stipulated limits. The design is well supported with the experimental results for the whole set-up along with the series switch at various voltage level before its approval for operation at 5.2 kV.

  4. The MQXA quadrupoles for the LHC low-beta insertions

    NASA Astrophysics Data System (ADS)

    Ajima, Y.; Higashi, N.; Iida, M.; Kimura, N.; Nakamoto, T.; Ogitsu, T.; Ohhata, H.; Ohuchi, N.; Shintomi, T.; Sugawara, S.; Sugita, K.; Tanaka, K.; Taylor, T.; Terashima, A.; Tsuchiya, K.; Yamamoto, A.

    2005-09-01

    High-performance superconducting quadrupole magnets, MQXA, for the LHC low-beta insertions have been designed, manufactured in series and tested. The design field gradient of the quadrupole, which has a coil aperture of diameter 70 mm, was 240 T/m at 1.9 K; its effective length is 6.37 m, and it is required to operate reliably at up to 215 T/m when subjected to radiation heat deposit in the coils of up to 5 W/m. The series of 20 magnets has been produced in industry, and tested at KEK. The magnet design is explained, and the construction and performance of the series units, in terms of training, field quality and geometry, are presented.

  5. Series-Bosch Technology for Oxygen Recovery During Lunar or Martian Surface Missions

    NASA Technical Reports Server (NTRS)

    Abney, Morgan B.; Mansell, J. Matthew; Rabenberg, Ellen; Stanley, Christine M.; Edmunson, Jennifer; Alleman, James E.; Chen, Kevin; Dumez, Sam

    2014-01-01

    Long-duration surface missions to the Moon or Mars will require life support systems that maximize resource recovery to minimize resupply from Earth. To address this need, NASA previously proposed a Series-Bosch (S-Bosch) oxygen recovery system, based on the Bosch process, which can theoretically recover 100% of the oxygen from metabolic carbon dioxide. Bosch processes have the added benefits of the potential to recover oxygen from atmospheric carbon dioxide and the use of regolith materials as catalysts, thereby eliminating the need for catalyst resupply from Earth. In 2012, NASA completed an initial design for an S-Bosch development test stand that incorporates two catalytic reactors in series including a Reverse Water-Gas Shift (RWGS) Reactor and a Carbon Formation Reactor (CFR). In 2013, fabrication of system components, with the exception of a CFR, and assembly of the test stand was initiated. Stand-alone testing of the RWGS reactor was completed to compare performance with design models. Continued testing of Lunar and Martian regolith simulants provided sufficient data to design a CFR intended to utilize these materials as catalysts. Finally, a study was conducted to explore the possibility of producing bricks from spent regolith catalysts. The results of initial demonstration testing of the RWGS reactor, results of continued catalyst performance testing of regolith simulants, and results of brick material properties testing are reported. Additionally, design considerations for a regolith-based CFR are discussed.

  6. Series-Bosch Technology for Oxygen Recovery During Lunar or Martian Surface Missions

    NASA Technical Reports Server (NTRS)

    Abney, Morgan B.; Mansell, James M.; Stanley, Christine; Edmunson, Jennifer; Dumez, Samuel; Chen, Kevin; Alleman, James E.

    2014-01-01

    Long-duration surface missions to the Moon or Mars will require life support systems that maximize resource recovery to minimize resupply from Earth. To address this need, NASA previously proposed a Series-Bosch (S-Bosch) oxygen recovery system, based on the Bosch process, which can theoretically recover 100% of the oxygen from metabolic carbon dioxide. Bosch processes have the added benefits of the potential to recover oxygen from atmospheric carbon dioxide and the use of regolith materials as catalysts, thereby eliminating the need for catalyst resupply from Earth. In 2012, NASA completed an initial design for an S-Bosch development test stand that incorporates two catalytic reactors in series including a Reverse Water-Gas Shift (RWGS) Reactor and a Carbon Formation Reactor (CFR). In 2013, fabrication of system components, with the exception of a CFR, and assembly of the test stand was initiated. Stand-alone testing of the RWGS reactor was completed to compare performance with design models. Continued testing of Lunar and Martian regolith simulants provided sufficient data to design a CFR intended to utilize these materials as catalysts. Finally, a study was conducted to explore the possibility of producing bricks from spend regolith catalysts. The results of initial demonstration testing of the RWGS reactor, results of continued catalyst performance testing of regolith simulants, and results of brick material properties testing are reported. Additionally, design considerations for a regolith-based CFR are discussed.

  7. BASINs and WEPP Climate Assessment Tools (CAT): Case ...

    EPA Pesticide Factsheets

    EPA announced the release of the final report, BASINs and WEPP Climate Assessment Tools (CAT): Case Study Guide to Potential Applications. This report supports application of two recently developed water modeling tools, the Better Assessment Science Integrating point & Non-point Sources (BASINS) and the Water Erosion Prediction Project Climate Assessment Tool (WEPPCAT). The report presents a series of short case studies designed to illustrate the capabilities of these tools for conducting scenario based assessments of the potential effects of climate change on streamflow and water quality. This report presents a series of short, illustrative case studies using the BASINS and WEPP climate assessment tools.

  8. Quantitative structure-property relationship (correlation analysis) of phosphonic acid-based chelates in design of MRI contrast agent.

    PubMed

    Tiwari, Anjani K; Ojha, Himanshu; Kaul, Ankur; Dutta, Anupama; Srivastava, Pooja; Shukla, Gauri; Srivastava, Rakesh; Mishra, Anil K

    2009-07-01

    Nuclear magnetic resonance imaging is a very useful tool in modern medical diagnostics, especially when gadolinium (III)-based contrast agents are administered to the patient with the aim of increasing the image contrast between normal and diseased tissues. With the use of soft modelling techniques such as quantitative structure-activity relationship/quantitative structure-property relationship after a suitable description of their molecular structure, we have studied a series of phosphonic acid for designing new MRI contrast agent. Quantitative structure-property relationship studies with multiple linear regression analysis were applied to find correlation between different calculated molecular descriptors of the phosphonic acid-based chelating agent and their stability constants. The final quantitative structure-property relationship mathematical models were found as--quantitative structure-property relationship Model for phosphonic acid series (Model 1)--log K(ML) = {5.00243(+/-0.7102)}- MR {0.0263(+/-0.540)}n = 12 l r l = 0.942 s = 0.183 F = 99.165 quantitative structure-property relationship Model for phosphonic acid series (Model 2)--log K(ML) = {5.06280(+/-0.3418)}- MR {0.0252(+/- .198)}n = 12 l r l = 0.956 s = 0.186 F = 99.256.

  9. Human Factors Engineering Bibliographic Series. Volume 5, 1967 Literature

    DTIC Science & Technology

    1976-03-01

    8217aining progracus designed to In- crease arn strength. There were 26 subects In each group. those In the experimental group, static and dyl’sic... experimental design over more usual classical procedures are Swq* gested.a’ 32,258 Cohen. 1t.l. CONTINUOUS VERSUS Tti. VISUAL FEEDSAX INl PRISM... experimental study was :?arformeed to evaluate, singly &no In combination, the effective- ness of a is-hr. training progrm and a set of visual aids designed to

  10. Heavy Duty Diesel Truck and Bus Hybrid Powertrain Study

    DTIC Science & Technology

    2012-03-01

    electric 22 ft. bus that offers greater range than battery-electric buses can provide. Designed to seat 22 passengers plus standees, this Ebus model...system that has both parallel and series operating modes. The relatively low volume of many truck and bus designs has inhibited the development of...that battery packs need to be designed for 50,000 lifetime energy storage cycles in a hybrid transit bus vs. just 3,600 cycles in the typical

  11. Theoretical-Numerical Study of Feasibility of Use of Winglets on Low Aspect Ration Wings at Subsonic and Transonic Mach Numbers to Reduce Drag

    NASA Technical Reports Server (NTRS)

    Kuhlman, John M.; Liaw, Paul; Cerney, Michael J.

    1988-01-01

    A numerical design study was conducted to assess the drag reduction potential of winglets installed on a series of low aspect ratio wings at a design point of M=0.8, C sub L=0.3. Wing-winglet and wing-alone design geometries were obtained for wings of aspect ratios between 1.75 and 2.67, having leading edge sweep angles between 45 and 60 deg. Winglet length was fixed at 15% of wing semispan. To assess the relative performance between wing-winglet and wing-alone configurations, the PPW nonlinear extended small disturbance potential flow code was utilized. This model has proven to yield plausible transonic flow field simulations for the series of low aspect ratio configurations selected. Predicted decreases in pressure drag coefficient for the wing-winglet configurations relative to the corresponding wing-alone planform are about 15% at the design point. Predicted decreases in wing-winglet total drag coefficient are about 12%, relative to the corresponding wing-alone design. Longer winglets (25% of the wing semispan) yielded decreases in the pressure drag of up to 22% and total drag of up to 16.4%. These predicted drag coefficient reductions are comparable to reductions already demonstrated by actual winglet designs installed on higher aspect ratio transport type aircraft.

  12. An Experimental Evaluation of the Internal Flow Field of an Automotive Heating, Ventilating and Air Conditioning System

    DTIC Science & Technology

    1990-07-01

    HVAC) was conducted. This study consisted of four primary experiments designed to provide a fairly complete description of the governing flow mechanisms...interest. In order to generate the 28 required optical characteristics, the laser beam was directed through a mechanical beam chopper and a series of...lenses. The beam chopper operated at a frequency of 75 chops per second to create series of laser pulses 1/75s in duration. Once chopped, the beam was

  13. Botulinum Neurotoxin Serotype A Inhibitors: Small-Molecule Mercaptoacetamide Analogs

    PubMed Central

    Moe, Scott T.; Thompson, Andrew B.; Smith, Genessa M.; Fredenburg, Ross A.; Stein, Ross L.; Jacobson, Alan R

    2009-01-01

    Botulinum neurotoxin elicits its paralytic activity through a zinc-dependant metalloprotease that cleaves proteins involved in neurotransmitter release. Currently, no drugs are available to reverse the effects of botulinum intoxication. Herein we report the design of a novel series of mercaptoacetamide small-molecule inhibitors active against botulinum neurotoxin serotype A. These analogs show low micromolar inhibitory activity against the isolated enzyme. Structure-activity relationship studies for a series of mercaptoacetamide analogs of 5-amino-3-phenylpyrazole reveal components essential for potent inhibitory activity. PMID:19329331

  14. Culture and Social Organization Module. Test Booklet. Test Items for Booklets 1, 2, 3, 4=Libro de prueba. Modulo de cultura y organizacion social. Itemes de prueba para los libros 1, 2, 3, 4.

    ERIC Educational Resources Information Center

    California State Univ., Los Angeles. National Dissemination and Assessment Center.

    The booklet is part of a grade 10-12 social studies series produced for bilingual education. The series consists of six major thematic modules, with four to five booklets in each. The interdisciplinary modules are based on major ideas and are designed to help students understand some major human problems and make sound, responsive decisions to…

  15. Problems in aerial application : I. - V.

    DOT National Transportation Integrated Search

    1966-06-01

    Airmen who apply insecticides from aircraft may suffer ill-defined effects from continued exposure to insecticide particles suspended in the air medium. The present series of experiments has been designed to study both lethal and sublethal effects re...

  16. Us and Them: Challenging the Divisions.

    ERIC Educational Resources Information Center

    Brown, Barbara B.

    1996-01-01

    Presents a series of class activities designed to counteract stereotypes of other people. Includes a hilarious parody of an anthropological study of the Nacirema (American spelled backwards). Satirizes American personal hygiene rituals, modern medical practices, and ethnocentric assumptions. (MJP)

  17. 14 CFR 26.11 - Electrical wiring interconnection systems (EWIS) maintenance program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... configuration of each model series airplane that incorporates all variations of EWIS used in production on that series airplane, and all TC-holder-designed modifications mandated by airworthiness directive as of the... effect on December 10, 2007 for each affected type design, and submit those ICA for review and approval...

  18. 14 CFR 26.11 - Electrical wiring interconnection systems (EWIS) maintenance program.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... configuration of each model series airplane that incorporates all variations of EWIS used in production on that series airplane, and all TC-holder-designed modifications mandated by airworthiness directive as of the... effect on December 10, 2007 for each affected type design, and submit those ICA for review and approval...

  19. 14 CFR 26.11 - Electrical wiring interconnection systems (EWIS) maintenance program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... configuration of each model series airplane that incorporates all variations of EWIS used in production on that series airplane, and all TC-holder-designed modifications mandated by airworthiness directive as of the... effect on December 10, 2007 for each affected type design, and submit those ICA for review and approval...

  20. 14 CFR 26.11 - Electrical wiring interconnection systems (EWIS) maintenance program.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... configuration of each model series airplane that incorporates all variations of EWIS used in production on that series airplane, and all TC-holder-designed modifications mandated by airworthiness directive as of the... effect on December 10, 2007 for each affected type design, and submit those ICA for review and approval...

  1. 14 CFR 26.11 - Electrical wiring interconnection systems (EWIS) maintenance program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... configuration of each model series airplane that incorporates all variations of EWIS used in production on that series airplane, and all TC-holder-designed modifications mandated by airworthiness directive as of the... effect on December 10, 2007 for each affected type design, and submit those ICA for review and approval...

  2. 46 CFR 108.550 - Survival craft launching and recovery arrangements: General.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... must be designed, based on the ultimate strength of the construction material, to be at least 4.5 times...-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Lifesaving Equipment § 108.550 Survival craft... approved under approval series 160.132, with a winch approved under approval series 160.115. Each launching...

  3. 46 CFR 108.550 - Survival craft launching and recovery arrangements: General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... must be designed, based on the ultimate strength of the construction material, to be at least 4.5 times...-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Lifesaving Equipment § 108.550 Survival craft... approved under approval series 160.132, with a winch approved under approval series 160.115. Each launching...

  4. Plants in the Classroom, An Environmental Investigation.

    ERIC Educational Resources Information Center

    National Wildlife Federation, Washington, DC.

    This environmental unit is one of a series designed for integration within the existing curriculum. The unit is self-contained and requires minimal teacher preparation. The philosophy of this series is based on an experience-oriented process that encourages self-paced independent student work. This particular unit, designed for the primary grades,…

  5. What Have We Learned from Communication Design Failure?

    ERIC Educational Resources Information Center

    Poggenpohl, Sharon; Winkler, Dietmar R.

    2010-01-01

    In closing, the guest editors of this "Visible Language" special series reflect on the failures identified in the various papers and interpret what this suggests for design education and research in the context of changing practice. The failures cited in this series point out the fractures in our understanding and practices from user-centered,…

  6. 49 CFR 451.25 - Required information.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451... same for all containers of a design-type or type-series covered by one notice of approval. (c) The safety approval number must be the same for all containers of a design-type or type-series covered by one...

  7. 49 CFR 451.25 - Required information.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451... same for all containers of a design-type or type-series covered by one notice of approval. (c) The safety approval number must be the same for all containers of a design-type or type-series covered by one...

  8. 49 CFR 451.25 - Required information.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451... same for all containers of a design-type or type-series covered by one notice of approval. (c) The safety approval number must be the same for all containers of a design-type or type-series covered by one...

  9. 49 CFR 451.25 - Required information.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS TESTING AND APPROVAL OF CONTAINERS Safety Approval Plate § 451... same for all containers of a design-type or type-series covered by one notice of approval. (c) The safety approval number must be the same for all containers of a design-type or type-series covered by one...

  10. Facility Issues in Community School Centers. #4 in a Series of 6 Booklets.

    ERIC Educational Resources Information Center

    Educational Facilities Labs., Inc., New York, NY.

    This booklet is the fourth in a series that examines community school centers. The development and substance of the building program, issues related to site selection and development, and overall building design strategies are examined. Also discussed are particularly important design details about which the programming committee and the architect…

  11. Cattails or Concrete?

    ERIC Educational Resources Information Center

    Heal, Fred A.; And Others

    Developed for elementary science studies, this unit on man and environment requires student involvement in discovery, observation, gathering and recording data, and problem solving. A series of 19 booklets, each designed as an activity which can be completed out-of-doors, comprise this student packet of materials. Topics studied in the activities…

  12. A case study : Chart II software upgrade, using a design competition to procure ITS software

    DOT National Transportation Integrated Search

    2000-03-01

    This is one of a series of case studies that examine procurement approaches used to deliver Intelligent Transportation System (ITS) projects. The purpose of these reports is to provide examples of successful strategies that have been used to overcome...

  13. 78 FR 20701 - Munder Series Trust, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... designed to ensure that the Sub-Advisers comply with a Sub- Advised Series' investment objectives, policies...] Munder Series Trust, et al.; Notice of Application March 29, 2013. AGENCY: Securities and Exchange... would grant relief from certain disclosure requirements. [[Page 20702

  14. Silverleaf: An Experimental Series in Support of Nightshade

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Danielson, Jeremy; Bauer, Amy L.

    2016-12-23

    In this series, a prototype package was designed and fielded to address a major technical risk of Nightshade: A comprehensive suite of drives and diagnostics must fit within a small space. In addition, this series satisfies a milestone for the project.

  15. Supersonic Retropropulsion Flight Test Concepts

    NASA Technical Reports Server (NTRS)

    Post, Ethan A.; Dupzyk, Ian C.; Korzun, Ashley M.; Dyakonov, Artem A.; Tanimoto, Rebekah L.; Edquist, Karl T.

    2011-01-01

    NASA's Exploration Technology Development and Demonstration Program has proposed plans for a series of three sub-scale flight tests at Earth for supersonic retropropulsion, a candidate decelerator technology for future, high-mass Mars missions. The first flight test in this series is intended to be a proof-of-concept test, demonstrating successful initiation and operation of supersonic retropropulsion at conditions that replicate the relevant physics of the aerodynamic-propulsive interactions expected in flight. Five sub-scale flight test article concepts, each designed for launch on sounding rockets, have been developed in consideration of this proof-of-concept flight test. Commercial, off-the-shelf components are utilized as much as possible in each concept. The design merits of the concepts are compared along with their predicted performance for a baseline trajectory. The results of a packaging study and performance-based trade studies indicate that a sounding rocket is a viable launch platform for this proof-of-concept test of supersonic retropropulsion.

  16. GRAM Series of Atmospheric Models for Aeroentry and Aeroassist

    NASA Technical Reports Server (NTRS)

    Duvall, Aleta; Justus, C. G.; Keller, Vernon W.

    2005-01-01

    The eight destinations in the Solar System with sufficient atmosphere for either aeroentry or aeroassist, including aerocapture, are: Venus, Earth, Mars, Jupiter, Saturn; Uranus. and Neptune, and Saturn's moon Titan. Engineering-level atmospheric models for four of these (Earth, Mars, Titan, and Neptune) have been developed for use in NASA's systems analysis studies of aerocapture applications in potential future missions. Work has recently commenced on development of a similar atmospheric model for Venus. This series of MSFC-sponsored models is identified as the Global Reference Atmosphere Model (GRAM) series. An important capability of all of the models in the GRAM series is their ability to simulate quasi-random perturbations for Monte Carlo analyses in developing guidance, navigation and control algorithms, and for thermal systems design. Example applications for Earth aeroentry and Mars aerocapture systems analysis studies are presented and illustrated. Current and planned updates to the Earth and Mars atmospheric models, in support of NASA's new exploration vision, are also presented.

  17. THE ANALYSIS OF THE TIME-SERIES FLUCTUATION OF WATER DEMAND FOR THE SMALL WATER SUPPLY BLOCK

    NASA Astrophysics Data System (ADS)

    Koizumi, Akira; Suehiro, Miki; Arai, Yasuhiro; Inakazu, Toyono; Masuko, Atushi; Tamura, Satoshi; Ashida, Hiroshi

    The purpose of this study is to define one apartment complex as "the water supply block" and to show the relationship between the amount of water supply for an apartment house and its time series fluctuation. We examined the observation data which were collected from 33 apartment houses. The water meters were installed at individual observation points for about 20 days in Tokyo. This study used Fourier analysis in order to grasp the irregularity in a time series data. As a result, this paper demonstrated that the smaller the amount of water supply became, the larger irregularity the time series fluctuation had. We also found that it was difficult to describe the daily cyclical pattern for a small apartment house using the dominant periodic components which were obtained from a Fourier spectrum. Our research give useful information about the design for a directional water supply system, as to making estimates of the hourly fluctuation and the maximum daily water demand.

  18. 76 FR 63818 - Special Conditions: Boeing Model 767-400ER Series Airplanes; Seats With Inflatable Lapbelts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... appropriate safety standards for the 767-400ER series airplanes because of a novel or unusual design feature...-1106; Special Conditions No. 25-448-SC] Special Conditions: Boeing Model 767-400ER Series Airplanes...- 400ER series airplane. These airplanes, as modified by Continental Airlines, will have a novel or...

  19. 26 CFR 1.1275-2 - Special rules relating to debt instruments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... an arrangement that is designed to avoid the aggregation rule (e.g., debt instruments issued by or to... instruments issued separately to other purchasers. On January 1, 1995, Corporation M issues two series of bonds, Series A and Series B. The two series are sold for cash and have different terms. Although some...

  20. A controlled time-series trial of clinical reminders: using computerized firm systems to make quality improvement research a routine part of mainstream practice.

    PubMed Central

    Goldberg, H. I.; Neighbor, W. E.; Cheadle, A. D.; Ramsey, S. D.; Diehr, P.; Gore, E.

    2000-01-01

    OBJECTIVE: To explore the feasibility of conducting unobtrusive interventional research in community practice settings by integrating firm-system techniques with time-series analysis of relational-repository data. STUDY SETTING: A satellite teaching clinic divided into two similar, but geographically separated, primary care group practices called firms. One firm was selected by chance to receive the study intervention. Forty-two providers and 2,655 patients participated. STUDY DESIGN: A nonrandomized controlled trial of computer-generated preventive reminders. Net effects were determined by quantitatively combining population-level data from parallel experimental and control interrupted time series extending over two-month baseline and intervention periods. DATA COLLECTION: Mean rates at which mammography, colorectal cancer screening, and cholesterol testing were performed on patients due to receive each maneuver at clinic visits were the trial's outcome measures. PRINCIPAL FINDINGS: Mammography performance increased on the experimental firm by 154 percent (0.24 versus 0.61, p = .03). No effect on fecal occult blood testing was observed. Cholesterol ordering decreased on both the experimental (0.18 versus 0.1 1, p = .02) and control firms (0.13 versus 0.07, p = .03) coincident with national guidelines retreating from recommending screening for young adults. A traditional uncontrolled interrupted time-series design would have incorrectly attributed the experimental-firm decrease to the introduction of reminders. The combined analysis properly indicated that no net prompting effect had occurred, as the difference between firms in cholesterol testing remained stochastically stable over time (0.05 versus 0.04, p = .75). A logistic-regression analysis applied to individual-level data produced equivalent findings. The trial incurred no supplementary data collection costs. CONCLUSIONS: The apparent validity and practicability of our reminder implementation study should encourage others to develop computerized firm systems capable of conducting controlled time-series trials. Images Fig. 1 PMID:10737451

  1. Integrated voice and visual systems research topics

    NASA Technical Reports Server (NTRS)

    Williams, Douglas H.; Simpson, Carol A.

    1986-01-01

    A series of studies was performed to investigate factors of helicopter speech and visual system design and measure the effects of these factors on human performance, both for pilots and non-pilots. The findings and conclusions of these studies were applied by the U.S. Army to the design of the Army's next generation threat warning system for helicopters and to the linguistic functional requirements for a joint Army/NASA flightworthy, experimental speech generation and recognition system.

  2. Profile design for wings and propellers

    NASA Technical Reports Server (NTRS)

    Quast, A.; Horstmann, K. H.

    1984-01-01

    It has now become customary to develop profiles for wings and propellers for a given employment of the aircraft. This is possible because methods and computers are available to study an entire series of variants in comparatively short time. The basic viewpoints for profile design are presented. It is shown that laminarization has its advantages in almost all cases, including the design of a turbine blade and the design of the profile of an airliner. The requirements which profiles have to satisfy are discussed along with the possibilities for increasing lift on profiles.

  3. Impact of an Innovative Classroom-Based Lecture Series on Residents' Evaluations of an Anesthesiology Rotation.

    PubMed

    Tanaka, Pedro; Yanez, David; Lemmens, Hendrikus; Djurdjulov, Adam; Scotto, Lena; Borg, Lindsay; Walker, Kim; Bereknyei Merrell, Sylvia; Macario, Alex

    2016-01-01

    Introduction. Millennial resident learners may benefit from innovative instructional methods. The goal of this study is to assess the impact of a new daily, 15 minutes on one anesthesia keyword, lecture series given by faculty member each weekday on resident postrotation evaluation scores. Methods. A quasi-experimental study design was implemented with the residents' rotation evaluations for the 24-month period ending by 7/30/2013 before the new lecture series was implemented which was compared to the 14-month period after the lecture series began on 8/1/2013. The primary endpoint was "overall teaching quality of this rotation." We also collected survey data from residents at clinical rotations at two other different institutions during the same two evaluation periods that did not have the education intervention. Results. One hundred and thirty-one residents were eligible to participate in the study. Completed surveys ranged from 77 to 87% for the eight-question evaluation instrument. On a 5-point Likert-type scale the mean score on "overall teaching quality of this rotation" increased significantly from 3.9 (SD 0.8) to 4.2 (SD 0.7) after addition of the lecture series, whereas the scores decreased slightly at the comparison sites. Conclusion. Rotation evaluation scores for overall teaching quality improved with implementation of a new structured slide daily lectures series.

  4. Academic Computing at Florida A&M University. A Case Study.

    ERIC Educational Resources Information Center

    Hunter, Beverly; Kearsley, Greg

    This case study is one of a series on academic computing at minority institutions which is designed to assist educators at other such institutions in identifying academic computing needs, establishing realistic goals, organizing a staff, and selecting materials. Following a brief description of the purpose and background of the overall study, the…

  5. Social Studies Program Guide, 3-6: Intermediate Grades.

    ERIC Educational Resources Information Center

    Spokane School District 81, WA.

    This curriculum guide suggests materials, resources, and activities related to social studies knowledge and skill development for grades 4-6. Third grade activities are also included to inform intermediate teachers what has been previously taught. Part of a series of social studies program guides designed to be used in the Spokane public schools…

  6. Social Studies Program Guide, 6-9.

    ERIC Educational Resources Information Center

    Spokane School District 81, WA.

    This curriculum guide suggests materials, resources, and activities related to social studies knowledge and skill development for grades 7-9. Grade 6 activities are also included to inform junior high school teachers what has been previously taught. Part of a series of social studies program guides designed to be used in Spokane public schools for…

  7. A Pilot Study of Integrated Listening Systems for Children with Sensory Processing Problems

    ERIC Educational Resources Information Center

    Schoen, Sarah A.; Miller, Lucy J.; Sullivan, Jillian

    2015-01-01

    This pilot study explored the effects of Integrated Listening Systems (iLs) Focus Series on individualized parent goals for children with sensory processing impairments. A nonconcurrent multiple baseline, repeated measure across participants, single-case study design was employed (n = 7). The 40-session intervention was delivered at home and in…

  8. Celebrations. Windows on Social Studies: Multiculutural Adventures through Literature.

    ERIC Educational Resources Information Center

    Westley, Joan; Melton, Holly

    This resource book is one in a series containing lesson plans for grades 1-3 designed to support children's literature books sharing familiar social studies themes. "Celebrations" presents eight different children's books related to the theme. For each book social studies concepts are presented, followed by four activities called "windows." Some…

  9. Teaching Canada for the '80s. Curriculum Series, 35.

    ERIC Educational Resources Information Center

    Hodgetts, A. B.; Gallagher, Paul

    A rationale for Canadian studies and outlines of appropriate content for various grade levels are presented. The book is designed to help teachers, curriculum planners, and teacher educators in preparing effective Canadian studies programs. Chapter I offers a discussion of the need for pan-Canadian understanding. Canadian studies can help young…

  10. Bilingual-Bicultural Curriculum for Social Studies: Grade 4.

    ERIC Educational Resources Information Center

    Keller, Anne; And Others

    Designed to assist bilingual teachers in providing a coordinated program of studies for students in the Connecticut Migratory Children's Program and others whose native language is Spanish, this social studies curriculum guide for fourth grade is one of a series for pre-school through fifth grade. The overall focus is on Puerto Rican history and…

  11. Bilingual Bicultural Curriculum for Social Studies: Grade Five.

    ERIC Educational Resources Information Center

    Loiselle, Maryann; And Others

    Designed to assist bilingual teachers in providing a coordinated program of studies for students in the Connecticut Migratory Children's Program and for other students whose native language is Spanish, this social studies curriculum guide for fifth grade is one of a series for pre-school through fifth grade. The overall focus is on Puerto Rican…

  12. National Longitudinal Transition Study 2012: Design Documentation. NCEE 2017-4021

    ERIC Educational Resources Information Center

    Burghardt, John; Haimson, Joshua; Lipscomb, Stephen; Liu, Albert Y.; Potter, Frank; Waits, Tiffany; Wang, Sheng

    2017-01-01

    The National Longitudinal Transition Study 2012 (NLTS 2012) is the third in the series of NLTS studies sponsored by the U.S. Department of Education to examine youth with disabilities receiving services under the Individuals with Disabilities Education Act (IDEA), a long-standing federal law last updated in 2004. Under IDEA, youth with…

  13. The Big Read: Case Studies

    ERIC Educational Resources Information Center

    National Endowment for the Arts, 2009

    2009-01-01

    The Big Read evaluation included a series of 35 case studies designed to gather more in-depth information on the program's implementation and impact. The case studies gave readers a valuable first-hand look at The Big Read in context. Both formal and informal interviews, focus groups, attendance at a wide range of events--all showed how…

  14. Before 1776. Study Guide.

    ERIC Educational Resources Information Center

    Gruenbaum, Thelma

    Designed for use at the elementary level, this study guide accompanies a short history of the life and culture of the Massachusetts Bay Colony prior to the American Revolution (see related document, ED 108 997). The guide provides additional material as well as a series of study questions, suggestions for additional reading, and field trips within…

  15. The design of PC/MISI, a PC-based common user interface to remote information storage and retrieval systems. Presentation visuals. M.S. Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Hall, Philip P.

    1985-01-01

    This Working Paper Series entry represents a collection of presentation visuals associated with the companion report entitled, The Design of PC/MISI, a PC-Based Common User Interface to Remote Information Storage and Retrieval Systems, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-15. The paper discusses the following: problem definition; the PC solution; the goals of system design; the design description; future considerations, the research environment; conclusions.

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chichester, Heather Jean MacLean; Hayes, Steven Lowe; Dempsey, Douglas

    This report summarizes the objectives of the current irradiation testing activities being undertaken by the Advanced Fuels Campaign relative to supporting the development and demonstration of innovative design features for metallic fuels in order to realize reliable performance to ultra-high burnups. The AFC-3 and AFC-4 test series are nearing completion; the experiments in this test series that have been completed or are in progress are reviewed and the objectives and test matrices for the final experiments in these two series are defined. The objectives, testing strategy, and test parameters associated with a future AFC test series, AFC-5, are documented. Finally,more » the future intersections and/or synergies of the AFC irradiation testing program with those of the TREAT transient testing program, emerging needs of proposed Versatile Test Reactor concepts, and the Joint Fuel Cycle Study program’s Integrated Recycle Test are discussed.« less

  17. The effectiveness of therapeutic assessment with an adult client: a single-case study using a time-series design.

    PubMed

    Aschieri, Filippo; Smith, Justin D

    2012-01-01

    This article presents the therapeutic assessment (TA; Finn, 2007) of a traumatized young woman named Claire. Claire reported feeling debilitated by academic demands and the expectations of her parents, and was finding it nearly impossible to progress in her studies. She was also finding it difficult to develop and sustain intimate relationships. The emotional aspects of close relationships were extremely difficult for her and she routinely blamed herself for her struggles in this arena. The assessor utilized the TA model for adults, with the exception of not including an optional intervention session. The steps of TA, particularly the extended inquiry and the discussion of test findings along the way, cultivated a supportive and empathic atmosphere with Claire. By employing the single-case time-series experimental design used in previous TA studies (e.g., Smith, Handler, & Nash, 2010; Smith, Wolf, Handler, & Nash, 2009), the authors demonstrated that Claire experienced statistically significant improvement correlated with the onset of TA. Results indicated that participation in TA coincided with a positive shift in the trajectory of her reported symptoms and with recognizing the affection she held for others in her life. This case illustrates the successful application of case-based time-series methodology in the evaluation of an adult TA. The potential implications for future study are discussed.

  18. Design for Life. Abortion. A Student's Lesson Plan [and] A Teacher's Lesson Plan [and] A Lawyer's Lesson Plan.

    ERIC Educational Resources Information Center

    Howard, Estelle; And Others

    One of a series of secondary level teaching units presenting case studies with pro and con analyses of particular legal problems, the document consists of a student's lesson plan, a teacher's lesson plan, and a lawyer's lesson plan for a unit on abortion. The lessons are designed to expose students to the Supreme Court's decision concerning…

  19. Final Report for Dynamic Models for Causal Analysis of Panel Data. Methods for Temporal Analysis. Part I, Chapter 1.

    ERIC Educational Resources Information Center

    Hannan, Michael T.; Tuma, Nancy Brandon

    This document is part of a series of chapters described in SO 011 759. Working from the premise that temporal analysis is indispensable for the study of change, the document examines major alternatives in research design of this nature. Five sections focus on the features, advantages, and limitations of temporal analysis. Four designs which…

  20. "Isms" Theme.

    ERIC Educational Resources Information Center

    Garrahy, Dennis J.

    One of a series of social studies units designed to develop the reading and writing skills of low achievers, this student activity book focuses on the theme of political systems and beliefs. The unit can be used for high school classes, individual study in alternative and continuing high schools, and adult education classes. Following an…

  1. Evidence for a Multidimensional Self-Efficacy for Exercise Scale

    ERIC Educational Resources Information Center

    Rodgers, W. M.; Wilson, P. M.; Hall, C. R.; Fraser, S. N.; Murray, T. C.

    2008-01-01

    This series of three studies considers the multidimensionality of exercise self-efficacy by examining the psychometric characteristics of an instrument designed to assess three behavioral subdomains: task, scheduling, and coping. In Study 1, exploratory factor analysis revealed the expected factor structure in a sample of 395 students.…

  2. [Secondary Career Education Activities: Social Studies.

    ERIC Educational Resources Information Center

    Radford City Schools, VA.

    The guide is one of a series developed in a pilot project to integrate career education concepts with subject matter in secondary grades. The units are designed to reveal career orientation aspects of traditional topics within five major subject areas: English, social studies, mathematics, science, and health and physical education. The lesson…

  3. Vocational Education Outcomes: An Evaluative Bibliography of Empirical Studies. Bibliography Series No. 49.

    ERIC Educational Resources Information Center

    Bolland, Kathleen A.

    As part of a project designed to identify appropriate and feasible methods of evaluating vocational education with respect to its outcomes, this bibliography contains descriptive and evaluative annotations of a selection of empirical studies of vocational education outcomes. Following a technical introduction discussing the methodological issues…

  4. War: Images of America. Social Studies Unit, Secondary Grades 7-12.

    ERIC Educational Resources Information Center

    Franklin, Edward; And Others

    Designed to accompany an audiovisual filmstrip series devoted to presenting a visual history of life in America, this guide helps secondary school teachers supplement social studies materials dealing with wars over the past 200 years. Using authentic visuals including paintings, drawings, engravings, posters, photographs, songsheets, and cartoons,…

  5. Revolution.

    ERIC Educational Resources Information Center

    Garrahy, Dennis J.

    One of a series of social studies units designed to develop the reading and writing skills of low achievers, this student activity book focuses on the theme of revolution. The unit can be used for high school classes, individual study in alternative and continuing high schools, and adult education classes. Following an introduction, material is…

  6. BASINS and WEPP Climate Assessment Tools (CAT): Case Study Guide to Potential Applications (External Review Draft)

    EPA Science Inventory

    This draft report supports application of two recently developed water modeling tools, the BASINS and WEPP climate assessment tools. The report presents a series of short case studies designed to illustrate the capabilities of these tools for conducting scenario based assessments...

  7. NHEXAS PHASE I ARIZONA STUDY--QUALITY SYSTEMS AND IMPLEMENTATION PLAN (QSIP).

    EPA Science Inventory

    The Arizona Consortium scoping studies were designed to be part of the total NHEXAS framework that was developed as a result of a series scientific discussions and workshops conducted by the US EPA from 1992 through 1993. Several scientific issues needed to be addressed to evalua...

  8. Grade/Study-Performance Contracts, Enhanced Communication, Cooperative Learning, and Student Performance in Undergraduate Organic Chemistry.

    ERIC Educational Resources Information Center

    Dougherty, Ralph C.

    1997-01-01

    Describes and evaluates a teaching strategy, designed to increase student retention while maintaining academic performance levels in undergraduate organic chemistry, that uses grade/study-performance contracts, enhanced communication using electronic mail, and cooperative learning. Concludes that a series of interventions can substantially…

  9. Consumerism Theme.

    ERIC Educational Resources Information Center

    Garrahy, Dennis J.

    One of a series of social studies units designed to develop the reading and writing skills of low achievers, this student activity book focuses on the theme of consumerism. The unit can be used for high school classes, individual study in alternative and continuing high schools, and adult education classes. Following an introduction, five sections…

  10. U.S. Metric Study Interim Report: Nonmanufacturing Businesses.

    ERIC Educational Resources Information Center

    National Bureau of Standards (DOC), Washington, DC.

    This is the fifth in a series of reports from the U. S. Metric Study, conducted by the National Bureau of Standards, designed to cover the nonmanufacturing segment of the economy representing about 65 percent of the total U. S. employment: mining, agriculture, forestry, fisheries, construction, transportation, communications, utilities,…

  11. 48 CFR 252.227-7013 - Rights in technical data-Noncommercial items.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... causing a computer to perform a specific operation or series of operations. (3) Computer software means computer programs, source code, source code listings, object code listings, design details, algorithms... funds; (ii) Studies, analyses, test data, or similar data produced for this contract, when the study...

  12. Energy Theme.

    ERIC Educational Resources Information Center

    Garrahy, Dennis J.

    One of a series of social studies units designed to develop the reading and writing skills of low achievers, this student activity book focuses on the theme of energy. The unit can be used for high school classes, individual study in alternative and continuing high schools, and adult education classes. Separate sections cover early sources of…

  13. Design, Synthesis, and Structure–Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity

    PubMed Central

    2015-01-01

    Antagonist and partial agonist modulators of the dopamine D3 receptor (D3R) have emerged as promising therapeutics for the treatment of substance abuse and neuropsychiatric disorders. However, development of druglike lead compounds with selectivity for the D3 receptor has been challenging because of the high sequence homology between the D3R and the dopamine D2 receptor (D2R). In this effort, we synthesized a series of acylaminobutylpiperazines incorporating aza-aromatic units and evaluated their binding and functional activities at the D3 and D2 receptors. Docking studies and results from evaluations against a set of chimeric and mutant receptors suggest that interactions at the extracellular end of TM7 contribute to the D3R versus D2R selectivity of these ligands. Molecular insights from this study could potentially enable rational design of potent and selective D3R ligands. PMID:25126833

  14. Design options for improved performance with high-density carbon ablators and low-gas fill hohlraum targets

    NASA Astrophysics Data System (ADS)

    Berzak Hopkins, L.; Divol, L.; Lepape, S.; Meezan, N. B.; Dewald, E.; Ho, D.; Khan, S.; Pak, A.; Ralph, J.; Ross, J. S.

    2016-10-01

    Recent simulation-based and experimental work using high-density carbon ablators in unlined uranium hohlraums with 0.3 mg/cc helium fill have demonstrated round implosions with minimal evolution of Legendre moment P2 during burn. To extend this promising work, design studies have been performed to explore potential performance improvements with larger capsules, while maintaining similar case-to-capsule target ratios. We present here the results of these design studies, which will motivate a series of upcoming experiments at the National Ignition Facility. Prepared by LLNL under Contract DE-AC52-07NA27344.

  15. DESIGN OF EXPOSURE MEASUREMENTS FOR EPIDEMIOLOGIC STUDIES

    EPA Science Inventory

    This presentation will describe the following items: (1) London daily air pollution and deaths that demonstrate how time series epidemiology can indicate that air pollution caused death; (2) Sophisticated statistical models required to establish this relationship for lower pollut...

  16. 76 FR 28914 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... of the rudder system design. Rudder pedal sensitivity on Model A300-600 and A310 series airplanes is... B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R Variant F Airplanes (Collectively Called A300-600 Series Airplanes); and Model A310 Series Airplanes AGENCY: Federal Aviation...

  17. A 10kW series resonant converter design, transistor characterization, and base-drive optimization

    NASA Technical Reports Server (NTRS)

    Robson, R.; Hancock, D.

    1981-01-01

    Transistors are characterized for use as switches in resonant circuit applications. A base drive circuit to provide the optimal base drive to these transistors under resonant circuit conditions is developed and then used in the design, fabrication and testing of a breadboard, spaceborne type 10 kW series resonant converter.

  18. The Understanding Words Reading Intervention: Evidence from a Case Series Design

    ERIC Educational Resources Information Center

    Wright, Craig; Conlon, Elizabeth G.; Wright, Michalle

    2012-01-01

    Using a case-series design with double baseline and 10-week maintenance phase, 5 struggling readers from middle- to high-income families (age range 6.4-7.9 years) completed a 5-times-weekly intervention (96 sessions) administered by a parent. All participants completed the intervention with phonological decoding, text-reading accuracy and reading…

  19. Natural language query system design for interactive information storage and retrieval systems. Presentation visuals. M.S. Thesis Final Report, 1 Jul. 1985 - 31 Dec. 1987

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Liu, I-Hsiung

    1985-01-01

    This Working Paper Series entry represents a collection of presentation visuals associated with the companion report entitled Natural Language Query System Design for Interactive Information Storage and Retrieval Systems, USL/DBMS NASA/RECON Working Paper Series report number DBMS.NASA/RECON-17.

  20. Playground Facilities and Equipment. ACSA School Management Digest, Series 1, Number 7. ERIC/CEM Research Analysis Series, Number 34.

    ERIC Educational Resources Information Center

    Coursen, David

    Modern educators and playground designers are increasingly recognizing that play is a part, perhaps the decisive part, of the entire learning process. Theories of playground equipment design, planning the playground, financial considerations, and equipment suggestions are featured in this review. Examples of playgrounds include innovative…

  1. The Leading Edge: A Career Development Workshop Series for Young Adults. Participant Workbook.

    ERIC Educational Resources Information Center

    Canadian Career Development Foundation, Ottawa (Ontario).

    This booklet is designed for participants in "The Leading Edge: A Career Development Workshop Series for Young Adults." It provides the 27 participant handouts for the six workshops in the series. The first in the series, "Setting the Stage: The Changing World of Work," is a workshop to clarify what is occurring in the world of…

  2. Summative Evaluation of Reading for a Reason: A Reading Series for Grades 7 and 8.

    ERIC Educational Resources Information Center

    Webb, Norman L.

    A summative evaluation of the instructional television series "Reading for a Reason" was conducted during the spring of 1982 as part of the premier showing of the series over the Wisconsin Educational Television Network. The series consisted of eight programs designed to teach skills for content area reading to seventh and eighth grade…

  3. The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

    PubMed

    Chen, Yan; Sit, Sing-Yuen; Chen, Jie; Swidorski, Jacob J; Liu, Zheng; Sin, Ny; Venables, Brian L; Parker, Dawn D; Nowicka-Sans, Beata; Lin, Zeyu; Li, Zhufang; Terry, Brian J; Protack, Tricia; Rahematpura, Sandhya; Hanumegowda, Umesh; Jenkins, Susan; Krystal, Mark; Dicker, Ira D; Meanwell, Nicholas A; Regueiro-Ren, Alicia

    2018-05-15

    The design and synthesis of a series of C28 amine-based betulinic acid derivatives as HIV-1 maturation inhibitors is described. This series represents a continuation of efforts following on from previous studies of C-3 benzoic acid-substituted betulinic acid derivatives as HIV-1 maturation inhibitors (MIs) that were explored in the context of C-28 amide substituents. Compared to the C-28 amide series, the C-28 amine derivatives exhibited further improvements in HIV-1 inhibitory activity toward polymorphisms in the Gag polyprotein as well as improved activity in the presence of human serum. However, plasma exposure of basic amines following oral administration to rats was generally low, leading to a focus on moderating the basicity of the amine moiety distal from the triterpene core. The thiomorpholine dioxide (TMD) 20 emerged from this study as a compound with the optimal antiviral activity and an acceptable pharmacokinetic profile in the C-28 amine series. Compared to the C-28 amide 3, 20 offers a 2- to 4-fold improvement in potency towards the screening viruses, exhibits low shifts in the EC 50 values toward the V370A and ΔV370 viruses in the presence of human serum or human serum albumin, and demonstrates improved potency towards the polymorphic T371A and V362I virus variants. Copyright © 2018 Elsevier Ltd. All rights reserved.

  4. Epoxy-based production of wind turbine rotor blades: occupational contact allergies.

    PubMed

    Pontén, Ann; Carstensen, Ole; Rasmussen, Kurt; Gruvberger, Birgitta; Isaksson, Marléne; Bruze, Magnus

    2004-03-01

    An industry producing rotor blades for wind turbines with an epoxy-based technology had experienced an increasing number of workers with dermatitis, among whom the frequency of occupational contact allergy (OCA) was suspected to be underestimated. To investigate the frequency of OCA by patch-testing with a specially profiled occupational patch test series. In a blinded study design, 603 workers were first interviewed and thereafter clinically examined. Based on a history of work-related skin disease, clinical findings of dermatitis, or both, 325 (53.9%) of the workers were patch-tested with an occupational patch test series and the European Standard patch test series. Of the 603 investigated workers, 10.9% had OCA and 5.6% had contact allergy to epoxy resin in the standard test series. Contact allergy to amine hardeners/catalysts was found in 4.1% of the workers. Among the workers with OCA, 48.5% reacted to work material other than epoxy resin in the European Standard patch test series. Approximately 50% of the workers with OCA would not have been detected if only the European Standard patch test series had been used.

  5. Designing for Persuasion: Toward Ambient Eco-Visualization for Awareness

    NASA Astrophysics Data System (ADS)

    Kim, Tanyoung; Hong, Hwajung; Magerko, Brian

    When people are aware of their lifestyle's ecological consequences, they are more likely to adjust their behavior to reduce their impact. Persuasive design that provides feedback to users without interfering with their primary tasks can increases the awareness of neighboring problems. As a case study of design for persuasion, we designed two ambient displays as desktop widgets. Both represent a users' computer usage time, but in different visual styles. In this paper, we present the results of a comparative study of two ambient displays. We discuss the gradual progress of persuasion supported by the ambient displays and the differences in users' perception affected by the different visualization styles. Finally, Our empirical findings lead to a series of design implications for persuasive media.

  6. Design and optimization of selective azaindole amide M1 positive allosteric modulators.

    PubMed

    Davoren, Jennifer E; O'Neil, Steven V; Anderson, Dennis P; Brodney, Michael A; Chenard, Lois; Dlugolenski, Keith; Edgerton, Jeremy R; Green, Michael; Garnsey, Michelle; Grimwood, Sarah; Harris, Anthony R; Kauffman, Gregory W; LaChapelle, Erik; Lazzaro, John T; Lee, Che-Wah; Lotarski, Susan M; Nason, Deane M; Obach, R Scott; Reinhart, Veronica; Salomon-Ferrer, Romelia; Steyn, Stefanus J; Webb, Damien; Yan, Jiangli; Zhang, Lei

    2016-01-15

    Selective activation of the M1 receptor via a positive allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated with schizophrenia and Alzheimer's disease. A novel series of azaindole amides and their key pharmacophore elements are described. The nitrogen of the azaindole core is a key design element as it forms an intramolecular hydrogen bond with the amide N-H thus reinforcing the bioactive conformation predicted by published SAR and our homology model. Representative compound 25 is a potent and selective M1 PAM that has well aligned physicochemical properties, adequate brain penetration and pharmacokinetic (PK) properties, and is active in vivo. These favorable properties indicate that this series possesses suitable qualities for further development and studies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Automated Solar Module Assembly Line

    NASA Technical Reports Server (NTRS)

    Bycer, M.

    1979-01-01

    The gathering of information that led to the design approach of the machine, and a summary of the findings in the areas of study along with a description of each station of the machine are discussed. The machine is a cell stringing and string applique machine which is flexible in design, capable of handling a variety of cells and assembling strings of cells which can then be placed in a matrix up to 4 ft x 2 ft. in series or parallel arrangement. The target machine cycle is to be 5 seconds per cell. This machine is primarily adapted to 100 MM round cells with one or two tabs between cells. It places finished strings of up to twelve cells in a matrix of up to six such strings arranged in series or in parallel.

  8. Visplause: Visual Data Quality Assessment of Many Time Series Using Plausibility Checks.

    PubMed

    Arbesser, Clemens; Spechtenhauser, Florian; Muhlbacher, Thomas; Piringer, Harald

    2017-01-01

    Trends like decentralized energy production lead to an exploding number of time series from sensors and other sources that need to be assessed regarding their data quality (DQ). While the identification of DQ problems for such routinely collected data is typically based on existing automated plausibility checks, an efficient inspection and validation of check results for hundreds or thousands of time series is challenging. The main contribution of this paper is the validated design of Visplause, a system to support an efficient inspection of DQ problems for many time series. The key idea of Visplause is to utilize meta-information concerning the semantics of both the time series and the plausibility checks for structuring and summarizing results of DQ checks in a flexible way. Linked views enable users to inspect anomalies in detail and to generate hypotheses about possible causes. The design of Visplause was guided by goals derived from a comprehensive task analysis with domain experts in the energy sector. We reflect on the design process by discussing design decisions at four stages and we identify lessons learned. We also report feedback from domain experts after using Visplause for a period of one month. This feedback suggests significant efficiency gains for DQ assessment, increased confidence in the DQ, and the applicability of Visplause to summarize indicators also outside the context of DQ.

  9. Operation of the J-series thruster using inert gas

    NASA Technical Reports Server (NTRS)

    Rawlin, V. K.

    1982-01-01

    Electron bombardment ion thrusters using inert gases are candidates for large space systems. The J-Series 30 cm diameter thruster, designed for operation up to 3 k-W with mercury, is at a state of technology readiness. The characteristics of operation with xenon, krypton, and argon propellants in a J-Series thruster with that obtained with mercury are compared. The performance of the discharge chamber, ion optics, and neutralizer and the overall efficiency as functions of input power and specific impulse and thruster lifetime were evaluated. As expected, the discharge chamber performance with inert gases decreased with decreasing atomic mass. Aspects of the J-Series thruster design which would require modification to provide operation at high power with insert gases were identified.

  10. Efficacy and Safety of Gabapentin in the Treatment of Chronic Cough: A Systematic Review.

    PubMed

    Shi, Guanglin; Shen, Qin; Zhang, Caixin; Ma, Jun; Mohammed, Anaz; Zhao, Huan

    2018-06-19

    Despite recent clinical guidelines, the optimal therapeutic strategy for the management of refractory chronic cough is still a challenge. The present systematic review was designed to assess the evidence for efficacy and safety of gabapentin in the treatment of chronic cough. A systematic search of PubMed, Embase, Cochrane Library databases, and publications cited in bibliographies was performed. Articles were searched by two reviewers with a priori criteria for study selection. Seven relevant articles were identified, including two randomized controlled trials, one prospective case-series designed with consecutive patients, one retrospective case series of consecutive patients, one retrospective case series with unknown consecutive status, and two case reports comprising six and two patients, respectively. Improvements were detected in cough-specific quality of life (Leicester Cough Questionnaire score) and cough severity (visual analogue scale score) following gabapentin treatment in randomized controlled trials. The results of prospective case-series showed that the rate of overall improvement of cough and sensory neuropathy with gabapentin was 68%. Gabapentin treatment of patients with chronic cough showed superior efficacy and a good safety record compared with placebo or standard medications. Additional randomized and controlled trials are needed. Copyright©2018. The Korean Academy of Tuberculosis and Respiratory Diseases.

  11. Two different flavours of complexity in financial data

    NASA Astrophysics Data System (ADS)

    Buonocore, R. J.; Musmeci, N.; Aste, T.; Matteo, T. Di

    2016-12-01

    We discuss two elements that define the complexity of financial time series: one is the multiscaling property, which is linked to how the statistics of a single time-series changes with the time horizon; the second is the structure of dependency between time-series, which accounts for the collective behaviour, i.e. the market structure. Financial time-series have statistical properties which change with the time horizon and the quantification of such multiscaling property has been successful to distinguish among different degrees of development of markets, monitor the stability of firms and estimate risk. The study of the structure of dependency between time-series with the use of information filtering graphs can reveal important insight on the market structure highlighting risks, stress and portfolio management strategies. In this contribution we highlight achievements, major successes and discuss major challenges and open problems in the study of these two elements of complexity, hoping to attract the interest of more researchers in this research area. We indeed believe that with the advent of the Big Data era, the need and the further development of such approaches, designed to deal with systems with many degrees of freedom, have become more urgent.

  12. Normalization of time-series satellite reflectance data to a standard sun-target-sensor geometry using a semi-empirical model

    NASA Astrophysics Data System (ADS)

    Zhao, Yongguang; Li, Chuanrong; Ma, Lingling; Tang, Lingli; Wang, Ning; Zhou, Chuncheng; Qian, Yonggang

    2017-10-01

    Time series of satellite reflectance data have been widely used to characterize environmental phenomena, describe trends in vegetation dynamics and study climate change. However, several sensors with wide spatial coverage and high observation frequency are usually designed to have large field of view (FOV), which cause variations in the sun-targetsensor geometry in time-series reflectance data. In this study, on the basis of semiempirical kernel-driven BRDF model, a new semi-empirical model was proposed to normalize the sun-target-sensor geometry of remote sensing image. To evaluate the proposed model, bidirectional reflectance under different canopy growth conditions simulated by Discrete Anisotropic Radiative Transfer (DART) model were used. The semi-empirical model was first fitted by using all simulated bidirectional reflectance. Experimental result showed a good fit between the bidirectional reflectance estimated by the proposed model and the simulated value. Then, MODIS time-series reflectance data was normalized to a common sun-target-sensor geometry by the proposed model. The experimental results showed the proposed model yielded good fits between the observed and estimated values. The noise-like fluctuations in time-series reflectance data was also reduced after the sun-target-sensor normalization process.

  13. Two States Mapping Based Time Series Neural Network Model for Compensation Prediction Residual Error

    NASA Astrophysics Data System (ADS)

    Jung, Insung; Koo, Lockjo; Wang, Gi-Nam

    2008-11-01

    The objective of this paper was to design a model of human bio signal data prediction system for decreasing of prediction error using two states mapping based time series neural network BP (back-propagation) model. Normally, a lot of the industry has been applied neural network model by training them in a supervised manner with the error back-propagation algorithm for time series prediction systems. However, it still has got a residual error between real value and prediction result. Therefore, we designed two states of neural network model for compensation residual error which is possible to use in the prevention of sudden death and metabolic syndrome disease such as hypertension disease and obesity. We determined that most of the simulation cases were satisfied by the two states mapping based time series prediction model. In particular, small sample size of times series were more accurate than the standard MLP model.

  14. Introduction to Carpentry. Introduction to Construction Series. Instructor Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This competency-based curriculum guide on the specialty area of carpentry is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in…

  15. Introduction to Bricklaying. Introduction to Construction Series. Instructor Edition.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This competency-based curriculum guide on the specialty area of bricklaying is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in…

  16. Innovative tools for quality assessment: integrated quality criteria for review of multiple study designs (ICROMS).

    PubMed

    Zingg, W; Castro-Sanchez, E; Secci, F V; Edwards, R; Drumright, L N; Sevdalis, N; Holmes, A H

    2016-04-01

    With the aim to facilitate a more comprehensive review process in public health including patient safety, we established a tool that we have termed ICROMS (Integrated quality Criteria for the Review Of Multiple Study designs), which unifies, integrates and refines current quality criteria for a large range of study designs including qualitative research. Review, pilot testing and expert consensus. The tool is the result of an iterative four phase process over two years: 1) gathering of established criteria for assessing controlled, non-controlled and qualitative study designs; 2) pilot testing of a first version in two systematic reviews on behavioural change in infection prevention and control and in antibiotic prescribing; 3) further refinement and adding of additional study designs in the context of the European Centre for Disease Prevention and Control funded project 'Systematic review and evidence-based guidance on organisation of hospital infection control programmes' (SIGHT); 4) scrutiny by the pan-European expert panel of the SIGHT project, which had the objective of ensuring robustness of the systematic review. ICROMS includes established quality criteria for randomised studies, controlled before-and-after studies and interrupted time series, and incorporates criteria for non-controlled before-and-after studies, cohort studies and qualitative studies. The tool consists of two parts: 1) a list of quality criteria specific for each study design, as well as criteria applicable across all study designs by using a scoring system; 2) a 'decision matrix', which specifies the robustness of the study by identifying minimum requirements according to the study type and the relevance of the study to the review question. The decision matrix directly determines inclusion or exclusion of a study in the review. ICROMS was applied to a series of systematic reviews to test its feasibility and usefulness in the appraisal of multiple study designs. The tool was applicable across a wide range of study designs and outcome measures. ICROMS is a comprehensive yet feasible appraisal of a large range of study designs to be included in systematic reviews addressing behaviour change studies in patient safety and public health. The tool is sufficiently flexible to be applied to a variety of other domains in health-related research. Beyond its application to systematic reviews, we envisage that ICROMS can have a positive effect on researchers to be more rigorous in their study design and more diligent in their reporting. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  17. Seismic vulnerability of new highway construction, executive summary.

    DOT National Transportation Integrated Search

    2002-03-01

    This executive summary gives an overview of the results of FHWA Contract DTFH61-92-C-00112, Seismic Research Program, : which performed a series of special studies addressing the seismic design of new construction. The objectives of this project : we...

  18. Seismic Vulnerability of New Highway Construction, Executive Summary.

    DOT National Transportation Integrated Search

    2002-03-01

    This executive summary gives an overview of the results of FHWA Contract DTFH61-92-C-00112, Seismic Research Program, which performed a series of special studies addressing the seismic design of new construction. The objectives of this project were t...

  19. Biology of an Enzyme: A Research-Like Experience for Introductory Biology Students.

    ERIC Educational Resources Information Center

    Towle, David W.

    1992-01-01

    Presents a series of laboratory exercises designed to introduce students to a realistic experience in biological research that is feasible with large numbers of beginning biology majors. The exercises center on the study of alkaline phosphatase. (DDR)

  20. Estimating and Enhancing Public Transit Accessibility for People with Mobility Limitations

    DOT National Transportation Integrated Search

    2017-06-30

    This two-part study employs fine-scale performance measures and analytical techniques designed to evaluate and improve transit services for people experiencing disability. Part one puts forth a series of time-sensitive, general transit feed system (G...

  1. Three-meter telescope study

    NASA Technical Reports Server (NTRS)

    Wissinger, A.; Scott, R. M.; Peters, W.; Augustyn, W., Jr.; Arnold, R.; Offner, A.; Damast, M.; Boyce, B.; Kinnaird, R.; Mangus, J. D.

    1971-01-01

    A means is presented whereby the effect of various changes in the most important parameters of a three meter aperature space astronomy telescope can be evaluated to determine design trends and to optimize the optical design configuration. Methods are defined for evaluating the theoretical optical performance of axisymmetric, centrally obscured telescopes based upon the intended astronomy research usage. A series of design parameter variations is presented to determine the optimum telescope configuration. The design optimum requires very fast primary mirrors, so the study also examines the current state of the art in fabricating large, fast primary mirrors. The conclusion is that a 3-meter primary mirror having a focal ratio as low as f/2 is feasible using currently established techniques.

  2. Probing Nuclear Spin Effects on Electronic Spin Coherence via EPR Measurements of Vanadium(IV) Complexes.

    PubMed

    Graham, Michael J; Krzyaniak, Matthew D; Wasielewski, Michael R; Freedman, Danna E

    2017-07-17

    Quantum information processing (QIP) has the potential to transform numerous fields from cryptography, to finance, to the simulation of quantum systems. A promising implementation of QIP employs unpaired electronic spins as qubits, the fundamental units of information. Though molecular electronic spins offer many advantages, including chemical tunability and facile addressability, the development of design principles for the synthesis of complexes that exhibit long qubit superposition lifetimes (also known as coherence times, or T 2 ) remains a challenge. As nuclear spins in the local qubit environment are a primary cause of shortened superposition lifetimes, we recently conducted a study which employed a modular spin-free ligand scaffold to place a spin-laden propyl moiety at a series of fixed distances from an S = 1 / 2 vanadium(IV) ion in a series of vanadyl complexes. We found that, within a radius of 4.0(4)-6.6(6) Å from the metal center, nuclei did not contribute to decoherence. To assess the generality of this important design principle and test its efficacy in a different coordination geometry, we synthesized and investigated three vanadium tris(dithiolene) complexes with the same ligand set employed in our previous study: K 2 [V(C 5 H 6 S 4 ) 3 ] (1), K 2 [V(C 7 H 6 S 6 ) 3 ] (2), and K 2 [V(C 9 H 6 S 8 ) 3 ] (3). We specifically interrogated solutions of these complexes in DMF-d 7 /toluene-d 8 with pulsed electron paramagnetic resonance spectroscopy and electron nuclear double resonance spectroscopy and found that the distance dependence present in the previously synthesized vanadyl complexes holds true in this series. We further examined the coherence properties of the series in a different solvent, MeCN-d 3 /toluene-d 8 , and found that an additional property, the charge density of the complex, also affects decoherence across the series. These results highlight a previously unknown design principle for augmenting T 2 and open new pathways for the rational synthesis of complexes with long coherence times.

  3. An Evolutionary Journey: The Case Study of East Muskingum Middle School. Transforming Learning Communities.

    ERIC Educational Resources Information Center

    Morrow, Linda E.; Martin, Kaye M.; Glascock, Catherine H.

    This book is part of a series of case studies that demonstrate better ways to educate Ohio's students. The case study is part of the Transforming Learning Communities (TLC) Project, designed to support significant school-reform efforts among Ohio's elementary, middle, and high schools. This report describes the implementation of an innovative…

  4. The Case Study Method: Guidelines, Practices, and Applications for Vocational Education. Research and Development Series No. 189.

    ERIC Educational Resources Information Center

    Spirer, Janet E.

    In comparison with traditional experimental design, which is concerned with what happened, a case study approach is more appropriate for answering the question of why or how something happened. As an alternative complementary-vocational-education-evaluation approach, the case study attempts to describe and analyze some program in comprehensive…

  5. Energy in an Interdependent World: A Global Development Studies Case Study.

    ERIC Educational Resources Information Center

    Collier, Anne B.

    Part of the Global Development Studies Institute series of model curricula, the teacher guide presents strategies for teaching about energy as a global issue. The unit, intended for students in grades 11-14, is designed for one semester. The overall objective is to promote awareness of and responsibility toward the global community through an…

  6. An Educational Institution's Quest for Service Quality: Customers' Perspective

    ERIC Educational Resources Information Center

    Joseph, Mathew; Yakhou, Mehenna; Stone, George

    2005-01-01

    Purpose: The purpose of the current study is to assess some of the self-reported factors that students in the study used as choice criteria in making their school selection. Design/methodology/approach: The results of this study were obtained by conducting a series of focus groups involving incoming freshmen at a small liberal arts university…

  7. Ethnographic Depiction of a Multiethnic School: A Comparison to Desegregated Settings.

    ERIC Educational Resources Information Center

    Semons, Maryann

    This report compares the findings of a recent ethnographic study of a multiethnic urban high school to some of the highlights of a series of ten-year-old ethnographic studies on court-ordered desegregated school settings. The study of the multiethnic urban school employed an ethnographic design whereby a participant-observer interviewed students…

  8. Quasi-experimental study designs series-paper 9: collecting data from quasi-experimental studies.

    PubMed

    Aloe, Ariel M; Becker, Betsy Jane; Duvendack, Maren; Valentine, Jeffrey C; Shemilt, Ian; Waddington, Hugh

    2017-09-01

    To identify variables that must be coded when synthesizing primary studies that use quasi-experimental designs. All quasi-experimental (QE) designs. When designing a systematic review of QE studies, potential sources of heterogeneity-both theory-based and methodological-must be identified. We outline key components of inclusion criteria for syntheses of quasi-experimental studies. We provide recommendations for coding content-relevant and methodological variables and outlined the distinction between bivariate effect sizes and partial (i.e., adjusted) effect sizes. Designs used and controls used are viewed as of greatest importance. Potential sources of bias and confounding are also addressed. Careful consideration must be given to inclusion criteria and the coding of theoretical and methodological variables during the design phase of a synthesis of quasi-experimental studies. The success of the meta-regression analysis relies on the data available to the meta-analyst. Omission of critical moderator variables (i.e., effect modifiers) will undermine the conclusions of a meta-analysis. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Mercury ion thruster technology

    NASA Technical Reports Server (NTRS)

    Beattie, J. R.; Matossian, J. N.

    1989-01-01

    The Mercury Ion Thruster Technology program was an investigation for improving the understanding of state-of-the-art mercury ion thrusters. Emphasis was placed on optimizing the performance and simplifying the design of the 30 cm diameter ring-cusp discharge chamber. Thruster performance was improved considerably; the baseline beam-ion production cost of the optimized configuration was reduced to Epsilon (sub i) perspective to 130 eV/ion. At a discharge propellant-utilization efficiency of 95 percent, the beam-ion production cost was reduced to about 155 eV/ion, representing a reduction of about 40 eV/ion over the corresponding value for the 30 cm diameter J-series thruster. Comprehensive Langmuir-probe surveys were obtained and compared with similar measurements for a J-series thruster. A successful volume-averaging scheme was developed to correlate thruster performance with the dominant plasma processes that prevail in the two thruster designs. The average Maxwellian electron temperature in the optimized ring-cusp design is as much as 1 eV higher than it is in the J-series thruster. Advances in ion-extraction electrode fabrication technology were made by improving materials selection criteria, hydroforming and stress-relieving tooling, and fabrications procedures. An ion-extraction performance study was conducted to assess the effect of screen aperture size on ion-optics performance and to verify the effectiveness of a beam-vectoring model for three-grid ion optics. An assessment of the technology readiness of the J-series thruster was completed, and operation of an 8 cm IAPS thruster using a simplified power processor was demonstrated.

  10. Teaching English as a Second Language: Perspectives and Practices. A Series of Six Texts. Speaking and Understanding: Second of a Series.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany.

    This book is designed to assist those who work with non-English dominant students by providing resource information relevant to second language teaching and learning. The articles in the series encompass both theory and practical learning techniques in six general topics. The articles in the second text of the series, concerning speaking and…

  11. Welcoming Blue-Collar Scholars into the Ivory Tower: Developing Class-Conscious Strategies for Student Success. Series on Special Student Populations

    ERIC Educational Resources Information Center

    Soria, Krista M.

    2015-01-01

    "Welcoming Blue-Collar Scholars Into the Ivory Tower" is the first volume in a new book series designed to explore how institutional policies, practices, and cultures shape learning, development, and success for students who have been historically underserved or given limited consideration in the design of higher education contexts.…

  12. A Unified Framework for Estimating Minimum Detectable Effects for Comparative Short Interrupted Time Series Designs

    ERIC Educational Resources Information Center

    Price, Cristofer; Unlu, Fatih

    2014-01-01

    The Comparative Short Interrupted Time Series (C-SITS) design is a frequently employed quasi-experimental method, in which the pre- and post-intervention changes observed in the outcome levels of a treatment group is compared with those of a comparison group where the difference between the former and the latter is attributed to the treatment. The…

  13. Monitoring the Performance of Groups of Formal and Concrete Cognitive Tendency Students Using an Intensive Time-Series Design.

    ERIC Educational Resources Information Center

    Monk, John S.; And Others

    A multiple-group, single-intervention intensive time-series design was used to examine the achievement of an abstract concept, plate tectonics, of students grouped on the basis of cognitive tendency. Two questions were addressed: (1) How do daily achievement patterns differ between formal and concrete cognitive tendency groups when learning an…

  14. Development of a Design Tool for Planning Aqueous Amendment Injection Systems Permanganate Design Tool

    DTIC Science & Technology

    2010-08-01

    CSTR continuously stirred tank reactors CT contact time EDB ethylene dibromide ESTCP Environmental Security Technology Certification Program...63 6.2 Simulating Oxidant Distribution Using a Series of CSTRs -------------------- 63 6.2.1 Model...SIMULATING OXIDANT DISTRIBUTION USING A SERIES OF CSTRS 6.2.1 MODEL DEVELOPMENT The transport and consumption of permanganate are simulated within the

  15. Empowering Grandparents Raising Grandchildren: A Training Manual for Group Leaders. Springer Series on Life Styles and Issues in Aging.

    ERIC Educational Resources Information Center

    Cox, Carole B.

    Noting that grandparents in the parenting role are often overwhelmed by the problems of their children, grandchildren, and the social milieu in which they live, this manual presents a 14-session workshop series designed to empower grandparents who are raising their grandchildren alone. Designed to complement "To Grandmother's House We Go and…

  16. A Teacher's Guide to Metrics. A Series of In-Service Booklets Designed for Adult Educators.

    ERIC Educational Resources Information Center

    Wendel, Robert, Ed.; And Others

    This series of seven booklets is designed to train teachers of adults in metrication, as a prerequisite to offering metrics in adult basic education and general educational development programs. The seven booklets provide a guide representing an integration of metric teaching methods and metric materials to place the adult in an active learning…

  17. Planning and Designing Academic Library Learning Spaces: Expert Perspectives of Architects, Librarians, and Library Consultants. Project Information Literacy Research Report. The Practitioner Series

    ERIC Educational Resources Information Center

    Head, Alison J.

    2016-01-01

    This paper identifies approaches, challenges, and best practices related to planning and designing today's academic library learning spaces. As part of the Project Information Literacy (PIL) Practitioner Series, qualitative data is presented from 49 interviews conducted with a sample of academic librarians, architects, and library consultants.…

  18. Exploring Orthogonal Hydrogen Bonding towards Designing Organic-Salt-Based Supramolecular Gelators: Synthesis, Structures, and Anticancer Properties.

    PubMed

    Chakraborty, Poulami; Dastidar, Parthasarathi

    2018-05-18

    A series of primary ammonium monocarboxylate (PAM) salts derived from β-alanine derivatives of pyrene and naphthalene acetic acid, along with the parent acids, were explored to probe the plausible role of orthogonal hydrogen bonding resulting from amide⋅⋅⋅amide and PAM synthons on gelation. Single-crystal X-ray diffraction (SXRD) studies were performed on two parent acids and five PAM salts in the series. The data revealed that orthogonal hydrogen bonding played an important role in gelation. Structure-property correlation based on SXRD and powder X-ray diffraction data also supported the working hypothesis upon which these gelators were designed. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and cell migration assay on a highly aggressive human breast cancer cell line, MDA-MB-231, revealed that one of the PAM salts in the series, namely, PAA.B2, displayed anticancer properties, and internalization of the gelator salt in the same cell line was confirmed by cell imaging. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.

    PubMed

    Huang, Wenlin; Zhang, Zhongsheng; Barros-Álvarez, Ximena; Koh, Cho Yeow; Ranade, Ranae M; Gillespie, J Robert; Creason, Sharon A; Shibata, Sayaka; Verlinde, Christophe L M J; Hol, Wim G J; Buckner, Frederick S; Fan, Erkang

    2016-11-29

    A screening hit 1 against Trypanosoma brucei methionyl-tRNA synthetase was optimized using a structure-guided approach. The optimization led to the identification of two novel series of potent inhibitors, the cyclic linker and linear linker series. Compounds of both series were potent in a T. brucei growth inhibition assay while showing low toxicity to mammalian cells. The best compound of each series, 16 and 31, exhibited EC 50 s of 39 and 22 nM, respectively. Compounds 16 and 31 also exhibited promising PK properties after oral dosing in mice. Moreover, compound 31 had moderately good brain permeability, with a brain/plasma ratio of 0.27 at 60 min after IP injection. This study provides new lead compounds for arriving at new treatments of human African trypanosomiasis (HAT). Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  20. Quasi-Experimental Designs for Causal Inference

    ERIC Educational Resources Information Center

    Kim, Yongnam; Steiner, Peter

    2016-01-01

    When randomized experiments are infeasible, quasi-experimental designs can be exploited to evaluate causal treatment effects. The strongest quasi-experimental designs for causal inference are regression discontinuity designs, instrumental variable designs, matching and propensity score designs, and comparative interrupted time series designs. This…

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