47 CFR 101.1001 - Eligibility.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Eligibility. 101.1001 Section 101.1001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1001 Eligibility. Any entity, other than one precluded...

47 CFR 101.1001 - Eligibility.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Eligibility. 101.1001 Section 101.1001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1001 Eligibility. Any entity, other than one precluded...

47 CFR 101.1001 - Eligibility.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Eligibility. 101.1001 Section 101.1001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1001 Eligibility. Any entity, other than one precluded...

47 CFR 101.1001 - Eligibility.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Eligibility. 101.1001 Section 101.1001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1001 Eligibility. Any entity, other than one precluded...

47 CFR 101.1001 - Eligibility.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Eligibility. 101.1001 Section 101.1001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1001 Eligibility. Any entity, other than one precluded...

47 CFR 101.5 - Station authorization required.

Code of Federal Regulations, 2014 CFR

2014-10-01

... SERVICES FIXED MICROWAVE SERVICES Applications and Licenses General Filing Requirements § 101.5 Station... stations authorized under subpart H (Private Operational Fixed Point-to-Point Microwave Service), subpart I (Common Carrier Fixed Point-to-Point Microwave Service), and subpart L of this part (Local Multipoint...

47 CFR 101.5 - Station authorization required.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SERVICES FIXED MICROWAVE SERVICES Applications and Licenses General Filing Requirements § 101.5 Station... stations authorized under subpart H (Private Operational Fixed Point-to-Point Microwave Service), subpart I (Common Carrier Fixed Point-to-Point Microwave Service), and subpart L of this part (Local Multipoint...

47 CFR 101.5 - Station authorization required.

Code of Federal Regulations, 2013 CFR

2013-10-01

... SERVICES FIXED MICROWAVE SERVICES Applications and Licenses General Filing Requirements § 101.5 Station... stations authorized under subpart H (Private Operational Fixed Point-to-Point Microwave Service), subpart I (Common Carrier Fixed Point-to-Point Microwave Service), and subpart L of this part (Local Multipoint...

47 CFR 101.5 - Station authorization required.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SERVICES FIXED MICROWAVE SERVICES Applications and Licenses General Filing Requirements § 101.5 Station... stations authorized under subpart H (Private Operational Fixed Point-to-Point Microwave Service), subpart I (Common Carrier Fixed Point-to-Point Microwave Service), and subpart L of this part (Local Multipoint...

47 CFR 101.5 - Station authorization required.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SERVICES FIXED MICROWAVE SERVICES Applications and Licenses General Filing Requirements § 101.5 Station... stations authorized under subpart H (Private Operational Fixed Point-to-Point Microwave Service), subpart I (Common Carrier Fixed Point-to-Point Microwave Service), and subpart L of this part (Local Multipoint...

47 CFR 101.1009 - System operations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false System operations. 101.1009 Section 101.1009 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1009 System operations. (a) The licensee may construct...

47 CFR 101.1009 - System operations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false System operations. 101.1009 Section 101.1009 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1009 System operations. (a) The licensee may construct...

47 CFR 101.1009 - System operations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false System operations. 101.1009 Section 101.1009 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1009 System operations. (a) The licensee may construct...

47 CFR 101.1009 - System operations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false System operations. 101.1009 Section 101.1009 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1009 System operations. (a) The licensee may construct...

47 CFR 101.1009 - System operations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false System operations. 101.1009 Section 101.1009 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Multipoint Distribution Service § 101.1009 System operations. (a) The licensee may construct...

47 CFR 1.824 - Random selection procedures for Multichannel Multipoint Distribution Service and Multipoint...

Code of Federal Regulations, 2010 CFR

2010-10-01

... an ownership interest of more than 50 percent in the media of mass communication whose service areas... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Complaints, Applications, Tariffs...

47 CFR 22.623 - System configuration.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false System configuration. 22.623 Section 22.623... Paging and Radiotelephone Service Point-To-Multipoint Operation § 22.623 System configuration. This section requires a minimum configuration for point-to-multipoint systems using the channels listed in § 22...

47 CFR 22.623 - System configuration.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 2 2012-10-01 2012-10-01 false System configuration. 22.623 Section 22.623... Paging and Radiotelephone Service Point-To-Multipoint Operation § 22.623 System configuration. This section requires a minimum configuration for point-to-multipoint systems using the channels listed in § 22...

47 CFR 22.623 - System configuration.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false System configuration. 22.623 Section 22.623... Paging and Radiotelephone Service Point-To-Multipoint Operation § 22.623 System configuration. This section requires a minimum configuration for point-to-multipoint systems using the channels listed in § 22...

47 CFR 22.623 - System configuration.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false System configuration. 22.623 Section 22.623... Paging and Radiotelephone Service Point-To-Multipoint Operation § 22.623 System configuration. This section requires a minimum configuration for point-to-multipoint systems using the channels listed in § 22...

Free-form Airfoil Shape Optimization Under Uncertainty Using Maximum Expected Value and Second-order Second-moment Strategies

NASA Technical Reports Server (NTRS)

Huyse, Luc; Bushnell, Dennis M. (Technical Monitor)

2001-01-01

Free-form shape optimization of airfoils poses unexpected difficulties. Practical experience has indicated that a deterministic optimization for discrete operating conditions can result in dramatically inferior performance when the actual operating conditions are different from the - somewhat arbitrary - design values used for the optimization. Extensions to multi-point optimization have proven unable to adequately remedy this problem of "localized optimization" near the sampled operating conditions. This paper presents an intrinsically statistical approach and demonstrates how the shortcomings of multi-point optimization with respect to "localized optimization" can be overcome. The practical examples also reveal how the relative likelihood of each of the operating conditions is automatically taken into consideration during the optimization process. This is a key advantage over the use of multipoint methods.

47 CFR 101.139 - Authorization of transmitters.

Code of Federal Regulations, 2013 CFR

2013-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.139 Authorization of transmitters. (a) Unless...-point microwave and point-to-multipoint services under this part must be a type that has been verified...

47 CFR 101.139 - Authorization of transmitters.

Code of Federal Regulations, 2014 CFR

2014-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.139 Authorization of transmitters. (a) Unless...-point microwave and point-to-multipoint services under this part must be a type that has been verified...

47 CFR 101.139 - Authorization of transmitters.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.139 Authorization of transmitters. (a) Unless...-point microwave and point-to-multipoint services under this part must be a type that has been verified...

47 CFR 101.139 - Authorization of transmitters.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.139 Authorization of transmitters. (a) Unless...-point microwave and point-to-multipoint services under this part must be a type that has been verified...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

New Options for AV in Telecommunications

ERIC Educational Resources Information Center

Gelman, Morrie

1974-01-01

A discussion of MDS, a multi-point distribution service which is a recently evolved supplementary telecommunications service that suggests new possibilities for improving the reach, impact and effectiveness of audio-visual communications. (Author)

Alternative licensing arrangements and spectrum economics: The case of multipoint distribution service

NASA Technical Reports Server (NTRS)

Agnew, C. E.

1981-01-01

At present, the Federal Communications Commission assigns radio licenses following a determination of the public interest. Whenever mutually conflicting license applications are filed, the Commission holds a comparative hearing. This assignment mechanism is criticized as cumbersome and unrealiable, and three alternatives are proposed: increasing the available spectrum, and either auctions or lotteries of radio licenses. An analysis is presented of the present system and these alternative arrangments for assigning rights to the frequency spectrum for the Multipoint Distribution Service (MDS). Although MDS is a relatively minor radio service, it serves as a prototype for message distribution services with a large potential for use in business communications. Moreover, the way in which the initial batch of MDS licenses was assigned provides a unique opportunity for empirical work on the economics of the licensing process.

Multipoint Ignition of a Gas Mixture by a Microwave Subcritical Discharge with an Extended Streamer Structure

NASA Astrophysics Data System (ADS)

Aleksandrov, K. V.; Busleev, N. I.; Grachev, L. P.; Esakov, I. I.; Ravaev, A. A.

2018-02-01

The results of experimental studies on using an electrical discharge with an extended streamer structure in a quasioptical microwave beam in the multipoint ignition of a propane-air mixture have been reported. The pulsed microwave discharge was initiated at the interior surface of a quartz tube that was filled with the mentioned flammable mixture and introduced into a microwave beam with a subbreakdown initial field. Gas breakdown was initiated by an electromagnetic vibrator. The dependence of the type of discharge on the microwave field strength was examined, the lower concentration threshold of ignition of the propane-air mixture by the studied discharge was determined, and the dynamics of combustion of the flammable mixture with local and multipoint ignition were compared.

47 CFR 1.4000 - Restrictions impairing reception of television broadcast signals, direct broadcast satellite...

Code of Federal Regulations, 2011 CFR

2011-10-01

... antenna that is: (A) Used to receive video programming services via multipoint distribution services... radio, amateur (“HAM”) radio, Citizen's Band (CB) radio, and Digital Audio Radio Service (DARS) signals... reception of video programming services or devices used to receive or transmit fixed wireless signals shall...

Retrospective analysis: Conservative treatment of placenta increta with methotrexate.

PubMed

Zhang, Chunhua; Li, Hongyan; Zuo, Changting; Wang, Xietong

2018-05-01

To evaluate the efficacy of conservative treatment with methotrexate against placenta increta by two different routes of administration through retrospective analysis. A total of 54 women diagnosed with placenta increta after vaginal delivery were enrolled in this retrospective study. The participants accepted conservative management with methotrexate through either intravenous injection or local multi-point injection under ultrasound guidance. The treatment was considered effective if no hysterectomy was mandatory during the follow-up period. Out of the 54 cases, 21 patients were treated with methotrexate intravenously (group 1), and 33 patients received local multi-point injection to the placenta increta under ultrasound guidance (group 2). No maternal death occurred. In group 1, 10 patients expelled the placentas spontaneously, 7 patients underwent uterine curettage and 4 patients underwent hysterectomy for uncontrollable post-partum hemorrhage and infection. In group 2, 25 patients expelled placentas spontaneously and 8 patients underwent uterine curettage with no incidence of hysterectomy. The success rate in group 1 and group 2 was 17/21 and 33/33, respectively. The average time of the spontaneous placenta expulsion was 79.13 ± 29.87 days in group 1 and 42.42 ± 31.83 days in group 2. Local multi-point methotrexate injection under ultrasound guidance is a better alternative for patients with placenta increta, especially for preserving fertility. © 2018 Japan Society of Obstetrics and Gynecology.

Remote Sensing of the Reconnection Electric Field From In Situ Multipoint Observations of the Separatrix Boundary

NASA Astrophysics Data System (ADS)

Nakamura, T. K. M.; Nakamura, R.; Varsani, A.; Genestreti, K. J.; Baumjohann, W.; Liu, Y.-H.

2018-05-01

A remote sensing technique to infer the local reconnection electric field based on in situ multipoint spacecraft observation at the reconnection separatrix is proposed. In this technique, the increment of the reconnected magnetic flux is estimated by integrating the in-plane magnetic field during the sequential observation of the separatrix boundary by multipoint measurements. We tested this technique by applying it to virtual observations in a two-dimensional fully kinetic particle-in-cell simulation of magnetic reconnection without a guide field and confirmed that the estimated reconnection electric field indeed agrees well with the exact value computed at the X-line. We then applied this technique to an event observed by the Magnetospheric Multiscale mission when crossing an energetic plasma sheet boundary layer during an intense substorm. The estimated reconnection electric field for this event is nearly 1 order of magnitude higher than a typical value of magnetotail reconnection.

Free choice access to multipoint wellness education and related services positively impacts employee wellness: a randomized and controlled trial.

PubMed

Sforzo, Gary A; Kaye, Miranda P; Calleri, David; Ngai, Nancy

2012-04-01

Examine effects of voluntary participation in employer-sponsored, multipoint wellness education programming on employee wellness. A randomized and controlled design was used to organize 96 participants into an education + access group; an access-only group, and control group. Outcome measures were made at start and end of a 12-week intervention period. Education + access improved wellness knowledge, which, in turn, enhanced life satisfaction, employee morale, and energy, and nearly improved stress level. Those who received facility access without educational programming did not reap health benefits. Employees voluntarily used the fitness facility and healthy meal cards only 1.3 and 1.5 times per week, respectively. Participants made limited and likely inadequate use of wellness opportunities. As a result, physical health benefits (eg, blood pressure, fitness parameters) were not seen in the present study. However, multipoint wellness education resulted in psychosocial health benefits in 12 weeks.

Multidetector Scattering as a Probe of Local Structure in Disordered Phases

NASA Astrophysics Data System (ADS)

Clark, Noel A.; Ackerson, Bruce J.; Hurd, Alan J.

1983-05-01

The local translational structure of a two-dimensional colloidal liquid is observed by use of cross correlation of the intensity fluctuations of light scattered by the liquid through two different wave vectors. The utility of multidetector scattering in probing multipoint correlations in disordered phases is thereby demonstrated unambiguously.

Coding and Modulation for LMDS and Analysis of the LMDS Channel

PubMed Central

Håkegård, Jan Erik

2000-01-01

Local Multipoint Distribution Service (LMDS) has the potential to become a viable alternative to coaxial cable, fiber and other wired and wireless technologies providing “last mile” communication services. A major obstacle, however, is the high equipment cost. While for example cable modems supporting two-way services are available for $200 to $300, LMDS modem providing similar services will cost over $1000. The major cost driver of LMDS equipment is the radio frequency (RF) unit, as Ka-band technology still is quite expensive. The modem design must minimize the overall architecture cost, and low-cost modems requiring an expensive architecture should not be used. The channel characteristics of LMDS systems are very different from those of fiber, coaxial cable, and lower frequency wireless links, major channel impairments being non-linear high power amplifier (HPA), high phase noise and high co-channel interference. Modems should therefore be developed specifically for LMDS systems. This report deals with the choice of coding and modulation schemes, the LMDS channel, and how the channel impairments should be overcome by digital signal processing algorithms. PMID:27551634

76 FR 78922 - Information Collections Being Reviewed by the Federal Communications Commission Under Delegated...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-20

...: This filing is the application for a Cable Television Relay Service (CARS) microwave radio license. Franchised cable systems and other eligible services use the 2, 7, 12 and 18 GHz CARS bands for microwave... of the river or mountain) or many points (``multipoint'') via microwave. The filing is done for an...

Multipoint propagators for non-Gaussian initial conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernardeau, Francis; Sefusatti, Emiliano; Crocce, Martin

2010-10-15

We show here how renormalized perturbation theory calculations applied to the quasilinear growth of the large-scale structure can be carried on in presence of primordial non-Gaussian (PNG) initial conditions. It is explicitly demonstrated that the series reordering scheme proposed in Bernardeau, Crocce, and Scoccimarro [Phys. Rev. D 78, 103521 (2008)] is preserved for non-Gaussian initial conditions. This scheme applies to the power spectrum and higher-order spectra and is based on a reorganization of the contributing terms into the sum of products of multipoint propagators. In case of PNG, new contributing terms appear, the importance of which is discussed in themore » context of current PNG models. The properties of the building blocks of such resummation schemes, the multipoint propagators, are then investigated. It is first remarked that their expressions are left unchanged at one-loop order irrespective of statistical properties of the initial field. We furthermore show that the high-momentum limit of each of these propagators can be explicitly computed even for arbitrary initial conditions. They are found to be damped by an exponential cutoff whose expression is directly related to the moment generating function of the one-dimensional displacement field. This extends what had been established for multipoint propagators for Gaussian initial conditions. Numerical forms of the cutoff are shown for the so-called local model of PNG.« less

Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scores.

PubMed

Xing, Chao; Elston, Robert C

2006-07-01

The multipoint lod score and mod score methods have been advocated for their superior power in detecting linkage. However, little has been done to determine the distribution of multipoint lod scores or to examine the properties of mod scores. In this paper we study the distribution of multipoint lod scores both analytically and by simulation. We also study by simulation the distribution of maximum multipoint lod scores when maximized over different penetrance models. The multipoint lod score is approximately normally distributed with mean and variance that depend on marker informativity, marker density, specified genetic model, number of pedigrees, pedigree structure, and pattern of affection status. When the multipoint lod scores are maximized over a set of assumed penetrances models, an excess of false positive indications of linkage appear under dominant analysis models with low penetrances and under recessive analysis models with high penetrances. Therefore, caution should be taken in interpreting results when employing multipoint lod score and mod score approaches, in particular when inferring the level of linkage significance and the mode of inheritance of a trait.

Local Network Wideband Interconnection Alternatives.

DTIC Science & Technology

1984-01-01

signal. 3.2.2 Limitations Although satellites offer the advantages of insensitivity to distance, point-to-multipoint communication capability and...Russell, the CATV franchisee for the town of Bedford, has not yit set rates for leasing channels on their network. If this network were interconnected

47 CFR 22.625 - Transmitter locations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Transmitter locations. 22.625 Section 22.625... Paging and Radiotelephone Service Point-To-Multipoint Operation § 22.625 Transmitter locations. This... channels will occur. (1) Control transmitter locations. Control transmitter locations must be within 80...

Technical and economic feasibility of integrated video service by satellite

NASA Technical Reports Server (NTRS)

Price, Kent M.; Garlow, R. K.; Henderson, T. R.; Kwan, Robert K.; White, L. W.

1992-01-01

The trends and roles of satellite based video services in the year 2010 time frame are examined based on an overall network and service model for that period. Emphasis is placed on point to point and multipoint service, but broadcast could also be accommodated. An estimate of the video traffic is made and the service and general network requirements are identified. User charges are then estimated based on several usage scenarios. In order to accommodate these traffic needs, a 28 spot beam satellite architecture with on-board processing and signal mixing is suggested.

Model reduction of nonsquare linear MIMO systems using multipoint matrix continued-fraction expansions

NASA Technical Reports Server (NTRS)

Guo, Tong-Yi; Hwang, Chyi; Shieh, Leang-San

1994-01-01

This paper deals with the multipoint Cauer matrix continued-fraction expansion (MCFE) for model reduction of linear multi-input multi-output (MIMO) systems with various numbers of inputs and outputs. A salient feature of the proposed MCFE approach to model reduction of MIMO systems with square transfer matrices is its equivalence to the matrix Pade approximation approach. The Cauer second form of the ordinary MCFE for a square transfer function matrix is generalized in this paper to a multipoint and nonsquare-matrix version. An interesting connection of the multipoint Cauer MCFE method to the multipoint matrix Pade approximation method is established. Also, algorithms for obtaining the reduced-degree matrix-fraction descriptions and reduced-dimensional state-space models from a transfer function matrix via the multipoint Cauer MCFE algorithm are presented. Practical advantages of using the multipoint Cauer MCFE are discussed and a numerical example is provided to illustrate the algorithms.

A National Satellite-Based System for Providing Continuing Education to Engineers.

ERIC Educational Resources Information Center

Georgia Inst. of Tech., Atlanta.

This document proposes, and indicates initial reaction to, a multi-point satellite-based delivery system which will permit expansion of current programs and services of the Association for Media-based Continuing Education for Engineers, Inc. (AMCEE) consortium to a much larger aggregated audience of practicing engineers throughout the country. It…

The possibilities for mobile and fixed services up to the 20/30 GHz frequency bands

NASA Astrophysics Data System (ADS)

Hughes, Clifford D.; Feliciani, F.; Spiller, J.

Satellite Communications and broadcasting is presently in a period of considerable change. In the fixed service there is strong competition from terrestrial fiber optic systems which have virtually arrested the growth of the traditional satellite market for long distance high capacity communications. The satellite has however made considerable progress in areas where it has unique advantages; for example, in point to multipoint (broadcasting), multipoint to point (data collection) and generally in small terminal system applications where flexibility of deployment coupled with ease of installation are of importance. In the mobile service, in addition to the already established geostationary systems, there are numerous proposals for HEO, MEO and LEO systems. There are also several new frequency allocations as a result of the WARC 92 to be taken into account. At one extreme there are researchers working on Ka band 20/30 GHz mobile systems and there are other groups who foresee no future above the L-band frequency allocations. Amongst all these inputs it is difficult to see the direction in which development activities both for satellites and for earth segment should be focused. However, as an aid to understanding, this paper seeks to find some underlying relationships and to clarify some of the variables.

The possibilities for mobile and fixed services up to the 20/30 GHz frequency bands

NASA Technical Reports Server (NTRS)

Hughes, Clifford D.; Feliciani, F.; Spiller, J.

1993-01-01

Satellite Communications and broadcasting is presently in a period of considerable change. In the fixed service there is strong competition from terrestrial fiber optic systems which have virtually arrested the growth of the traditional satellite market for long distance high capacity communications. The satellite has however made considerable progress in areas where it has unique advantages; for example, in point to multipoint (broadcasting), multipoint to point (data collection) and generally in small terminal system applications where flexibility of deployment coupled with ease of installation are of importance. In the mobile service, in addition to the already established geostationary systems, there are numerous proposals for HEO, MEO and LEO systems. There are also several new frequency allocations as a result of the WARC 92 to be taken into account. At one extreme there are researchers working on Ka band 20/30 GHz mobile systems and there are other groups who foresee no future above the L-band frequency allocations. Amongst all these inputs it is difficult to see the direction in which development activities both for satellites and for earth segment should be focused. However, as an aid to understanding, this paper seeks to find some underlying relationships and to clarify some of the variables.

Plasma jets in the near-Earth's magnetotail (Julius Bartels Medal Lecture)

NASA Astrophysics Data System (ADS)

Nakamura, Rumi

2014-05-01

The Earth's magnetosphere is formed as a consequence of the interaction between the magnetized solar wind and the terrestrial magnetic field. While the large-scale and average (>hours) properties of the Earth's magnetotail current sheet can be well described by overall solar wind-magnetosphere interaction, the most dramatic energy conversion process takes place in an explosive manner involving transient (up to several minutes) and localized (up to a few RE) phenomena in the plasma sheet/current sheet regions. One of the most clear observables of such processes are the localized and transient plasma jets called Bursty bulk flows (BBF), embedding velocity peaks of 1-min duration, which are called flow bursts. This talk is a review of the current understanding of these plasma jets by highlighting the results from multi-spacecraft observations by the Cluster and THEMIS spacecraft. The first four-spacecraft mission Cluster crossed the near-Earth plasma sheet with inter-spacecraft distance of about 250 km to 10000 km, ideal for studying local structures of the flow bursts. The five-spacecraft THEMIS mission , separated by larger distances , succeeded to monitor the large-scale evolution of the fast flows from the mid-tail to the inner magnetosphere. Multi-point observations of BBFS have established the importance of measuring local gradients of the fields and the plasma to understand the BBF structures such as the spatial scales and 3D structure of localized Earthward convecting flux tubes. Among others the magnetic field disturbance forming at the front of BBF, called dipolarization front (DF), has been intensively studied. From the propagation properties of DF relative to the flows and by comparing with ionospheric data, the evolution of the fast flows in terms of magnetosphere-ionospheric coupling through field-aligned currents are established. An important aspect of BBF is the interaction of the Earthward plasma jets and the Earth's dipole field. Multi-point observations combined with ground-based observations enabled to resolve how the BBFs are braked , diverted, or bounced back at the high-pressure gradient region. The multi-point capabilities in space enabled to study the BBF structure as well as large-scale evolution of BBFs. These processes are also universal processes in space plasmas and are, for example, associated with the reconnection process during the solar flares or leading to auroral phenomena at different planets.

A Standard-Compliant Virtual Meeting System with Active Video Object Tracking

NASA Astrophysics Data System (ADS)

Lin, Chia-Wen; Chang, Yao-Jen; Wang, Chih-Ming; Chen, Yung-Chang; Sun, Ming-Ting

2002-12-01

This paper presents an H.323 standard compliant virtual video conferencing system. The proposed system not only serves as a multipoint control unit (MCU) for multipoint connection but also provides a gateway function between the H.323 LAN (local-area network) and the H.324 WAN (wide-area network) users. The proposed virtual video conferencing system provides user-friendly object compositing and manipulation features including 2D video object scaling, repositioning, rotation, and dynamic bit-allocation in a 3D virtual environment. A reliable, and accurate scheme based on background image mosaics is proposed for real-time extracting and tracking foreground video objects from the video captured with an active camera. Chroma-key insertion is used to facilitate video objects extraction and manipulation. We have implemented a prototype of the virtual conference system with an integrated graphical user interface to demonstrate the feasibility of the proposed methods.

A small spacecraft for multipoint measurement of ionospheric plasma.

PubMed

Roberts, T M; Lynch, K A; Clayton, R E; Weiss, J; Hampton, D L

2017-07-01

Measurement of ionospheric plasma is often performed by a single in situ device or remotely using cameras and radar. This article describes a small, low-resource, deployed spacecraft used as part of a local, multipoint measurement network. A B-field aligned sounding rocket ejects four of these spin-stabilized spacecraft in a cross pattern. In this application, each spacecraft carries two retarding potential analyzers which are used to determine plasma density, flow, and ion temperature. An inertial measurement unit and a light-emitting diode array are used to determine the position and orientation of the devices after deployment. The design of this spacecraft is first described, and then results from a recent test flight are discussed. This flight demonstrated the successful operation of the deployment mechanism and telemetry systems, provided some preliminary plasma measurements in a simple mid-latitude environment, and revealed several design issues.

A small spacecraft for multipoint measurement of ionospheric plasma

NASA Astrophysics Data System (ADS)

Roberts, T. M.; Lynch, K. A.; Clayton, R. E.; Weiss, J.; Hampton, D. L.

2017-07-01

Measurement of ionospheric plasma is often performed by a single in situ device or remotely using cameras and radar. This article describes a small, low-resource, deployed spacecraft used as part of a local, multipoint measurement network. A B-field aligned sounding rocket ejects four of these spin-stabilized spacecraft in a cross pattern. In this application, each spacecraft carries two retarding potential analyzers which are used to determine plasma density, flow, and ion temperature. An inertial measurement unit and a light-emitting diode array are used to determine the position and orientation of the devices after deployment. The design of this spacecraft is first described, and then results from a recent test flight are discussed. This flight demonstrated the successful operation of the deployment mechanism and telemetry systems, provided some preliminary plasma measurements in a simple mid-latitude environment, and revealed several design issues.

Cryogenic-temperature profiling of high-power superconducting lines using local and distributed optical-fiber sensors.

PubMed

Chiuchiolo, Antonella; Palmieri, Luca; Consales, Marco; Giordano, Michele; Borriello, Anna; Bajas, Hugues; Galtarossa, Andrea; Bajko, Marta; Cusano, Andrea

2015-10-01

This contribution presents distributed and multipoint fiber-optic monitoring of cryogenic temperatures along a superconducting power transmission line down to 30 K and over 20 m distance. Multipoint measurements were conducted using fiber Bragg gratings sensors coated with two different functional overlays (epoxy and poly methyl methacrylate (PMMA)) demonstrating cryogenic operation in the range 300-4.2 K. Distributed measurements exploited optical frequency-domain reflectometry to analyze the Rayleigh scattering along two concatenated fibers with different coatings (acrylate and polyimide). The integrated system has been placed along the 20 m long cryostat of a superconducting power transmission line, which is currently being tested at the European Organization for Nuclear Research (CERN). Cool-down events from 300-30 K have been successfully measured in space and time, confirming the viability of these approaches to the monitoring of cryogenic temperatures along a superconducting transmission line.

Multipoint Fuel Injection Arrangements

NASA Technical Reports Server (NTRS)

Prociw, Lev Alexander (Inventor)

2017-01-01

A multipoint fuel injection system includes a plurality of fuel manifolds. Each manifold is in fluid communication with a plurality of injectors arranged circumferentially about a longitudinal axis for multipoint fuel injection. The injectors of separate respective manifolds are spaced radially apart from one another for separate radial staging of fuel flow to each respective manifold.

Local versus global aortic pulse wave velocity in early atherosclerosis: An animal study in ApoE-/--mice using ultrahigh field MRI

PubMed Central

Gotschy, Alexander; Bauer, Wolfgang R.; Winter, Patrick; Nordbeck, Peter; Rommel, Eberhard; Jakob, Peter M.; Herold, Volker

2017-01-01

Increased aortic stiffness is known to be associated with atherosclerosis and has a predictive value for cardiovascular events. This study aims to investigate the local distribution of early arterial stiffening due to initial atherosclerotic lesions. Therefore, global and local pulse wave velocity (PWV) were measured in ApoE-/- and wild type (WT) mice using ultrahigh field MRI. For quantification of global aortic stiffness, a new multi-point transit-time (TT) method was implemented and validated to determine the global PWV in the murine aorta. Local aortic stiffness was measured by assessing the local PWV in the upper abdominal aorta, using the flow/area (QA) method. Significant differences between age matched ApoE-/- and WT mice were determined for global and local PWV measurements (global PWV: ApoE-/-: 2.7±0.2m/s vs WT: 2.1±0.2m/s, P<0.03; local PWV: ApoE-/-: 2.9±0.2m/s vs WT: 2.2±0.2m/s, P<0.03). Within the WT mouse group, the global PWV correlated well with the local PWV in the upper abdominal aorta (R2 = 0.75, P<0.01), implying a widely uniform arterial elasticity. In ApoE-/- animals, however, no significant correlation between individual local and global PWV was present (R2 = 0.07, P = 0.53), implying a heterogeneous distribution of vascular stiffening in early atherosclerosis. The assessment of global PWV using the new multi-point TT measurement technique was validated against a pressure wire measurement in a vessel phantom and showed excellent agreement. The experimental results demonstrate that vascular stiffening caused by early atherosclerosis is unequally distributed over the length of large vessels. This finding implies that assessing heterogeneity of arterial stiffness by multiple local measurements of PWV might be more sensitive than global PWV to identify early atherosclerotic lesions. PMID:28207773

Local versus global aortic pulse wave velocity in early atherosclerosis: An animal study in ApoE-/--mice using ultrahigh field MRI.

PubMed

Gotschy, Alexander; Bauer, Wolfgang R; Winter, Patrick; Nordbeck, Peter; Rommel, Eberhard; Jakob, Peter M; Herold, Volker

2017-01-01

Increased aortic stiffness is known to be associated with atherosclerosis and has a predictive value for cardiovascular events. This study aims to investigate the local distribution of early arterial stiffening due to initial atherosclerotic lesions. Therefore, global and local pulse wave velocity (PWV) were measured in ApoE-/- and wild type (WT) mice using ultrahigh field MRI. For quantification of global aortic stiffness, a new multi-point transit-time (TT) method was implemented and validated to determine the global PWV in the murine aorta. Local aortic stiffness was measured by assessing the local PWV in the upper abdominal aorta, using the flow/area (QA) method. Significant differences between age matched ApoE-/- and WT mice were determined for global and local PWV measurements (global PWV: ApoE-/-: 2.7±0.2m/s vs WT: 2.1±0.2m/s, P<0.03; local PWV: ApoE-/-: 2.9±0.2m/s vs WT: 2.2±0.2m/s, P<0.03). Within the WT mouse group, the global PWV correlated well with the local PWV in the upper abdominal aorta (R2 = 0.75, P<0.01), implying a widely uniform arterial elasticity. In ApoE-/- animals, however, no significant correlation between individual local and global PWV was present (R2 = 0.07, P = 0.53), implying a heterogeneous distribution of vascular stiffening in early atherosclerosis. The assessment of global PWV using the new multi-point TT measurement technique was validated against a pressure wire measurement in a vessel phantom and showed excellent agreement. The experimental results demonstrate that vascular stiffening caused by early atherosclerosis is unequally distributed over the length of large vessels. This finding implies that assessing heterogeneity of arterial stiffness by multiple local measurements of PWV might be more sensitive than global PWV to identify early atherosclerotic lesions.

Transport induced by large scale convective structures in a dipole-confined plasma.

PubMed

Grierson, B A; Mauel, M E; Worstell, M W; Klassen, M

2010-11-12

Convective structures characterized by E×B motion are observed in a dipole-confined plasma. Particle transport rates are calculated from density dynamics obtained from multipoint measurements and the reconstructed electrostatic potential. The calculated transport rates determined from the large-scale dynamics and local probe measurements agree in magnitude, show intermittency, and indicate that the particle transport is dominated by large-scale convective structures.

TLNS3D/CDISC Multipoint Design of the TCA Concept

NASA Technical Reports Server (NTRS)

Campbell, Richard L.; Mann, Michael J.

1999-01-01

This paper presents the work done to date by the authors on developing an efficient approach to multipoint design and applying it to the design of the HSR TCA (High Speed Research Technology Concept Aircraft) configuration. While the title indicates that this exploratory study has been performed using the TLNS3DMB flow solver and the CDISC (Constrained Direct Iterative Surface Curvature) design method, the CDISC method could have been used with any flow solver, and the multipoint design approach does not require the use of CDISC. The goal of the study was to develop a multipoint design method that could achieve a design in about the same time as 10 analysis runs.

On shifted Jacobi spectral method for high-order multi-point boundary value problems

NASA Astrophysics Data System (ADS)

Doha, E. H.; Bhrawy, A. H.; Hafez, R. M.

2012-10-01

This paper reports a spectral tau method for numerically solving multi-point boundary value problems (BVPs) of linear high-order ordinary differential equations. The construction of the shifted Jacobi tau approximation is based on conventional differentiation. This use of differentiation allows the imposition of the governing equation at the whole set of grid points and the straight forward implementation of multiple boundary conditions. Extension of the tau method for high-order multi-point BVPs with variable coefficients is treated using the shifted Jacobi Gauss-Lobatto quadrature. Shifted Jacobi collocation method is developed for solving nonlinear high-order multi-point BVPs. The performance of the proposed methods is investigated by considering several examples. Accurate results and high convergence rates are achieved.

Experimental research and numerical optimisation of multi-point sheet metal forming implementation using a solid elastic cushion system

NASA Astrophysics Data System (ADS)

Tolipov, A. A.; Elghawail, A.; Shushing, S.; Pham, D.; Essa, K.

2017-09-01

There is a growing demand for flexible manufacturing techniques that meet the rapid changes in customer needs. A finite element analysis numerical optimisation technique was used to optimise the multi-point sheet forming process. Multi-point forming (MPF) is a flexible sheet metal forming technique where the same tool can be readily changed to produce different parts. The process suffers from some geometrical defects such as wrinkling and dimpling, which have been found to be the cause of the major surface quality problems. This study investigated the influence of parameters such as the elastic cushion hardness, blank holder force, coefficient of friction, cushion thickness and radius of curvature, on the quality of parts formed in a flexible multi-point stamping die. For those reasons, in this investigation, a multipoint forming stamping process using a blank holder was carried out in order to study the effects of the wrinkling, dimpling, thickness variation and forming force. The aim was to determine the optimum values of these parameters. Finite element modelling (FEM) was employed to simulate the multi-point forming of hemispherical shapes. Using the response surface method, the effects of process parameters on wrinkling, maximum deviation from the target shape and thickness variation were investigated. The results show that elastic cushion with proper thickness and polyurethane with the hardness of Shore A90. It has also been found that the application of lubrication cans improve the shape accuracy of the formed workpiece. These final results were compared with the numerical simulation results of the multi-point forming for hemispherical shapes using a blank-holder and it was found that using cushion hardness realistic to reduce wrinkling and maximum deviation.

Global Magnetosphere Evolution During 22 June 2015 Geomagnetic Storm as Seen From Multipoint Observations and Comparison With MHD-Ring Rurrent Model

NASA Astrophysics Data System (ADS)

Buzulukova, N.; Moore, T. E.; Dorelli, J.; Fok, M. C. H.; Sibeck, D. G.; Angelopoulos, V.; Goldstein, J.; Valek, P. W.; McComas, D. J.

2015-12-01

On 22-23 June 2015 a severe geomagnetic storm occurred with Dst minimum of approximately -200nT. During this extreme event, multipoint observations of magnetospheric dynamics were obtained by a fleet of Geospace spacecraft including MMS, TWINS, Van-Allen and THEMIS. We present analysis of satellite data during that event, and use a global coupled MHD-ring current model (BATSRUS-CRCM) to connect multipoint observations from different parts of the magnetosphere. The analysis helps to identify different magnetospheric domains from multipoint measurements and various magnetospheric boundary motions. We will explore how the initial disturbance from the solar wind propagates through the magnetosphere causing energization of plasma in the inner magnetosphere and producing an extreme geomagnetic storm.

Multipoint fiber-optic laser-ultrasonic actuator based on fiber core-opened tapers.

PubMed

Tian, Jiajun; Dong, Xiaolong; Gao, Shimin; Yao, Yong

2017-11-27

In this study, a novel fiber-optic, multipoint, laser-ultrasonic actuator based on fiber core-opened tapers (COTs) is proposed and demonstrated. The COTs were fabricated by splicing single-mode fibers using a standard fiber splicer. A COT can effectively couple part of a core mode into cladding modes, and the coupling ratio can be controlled by adjusting the taper length. Such characteristics are used to obtain a multipoint, laser-ultrasonic actuator with balanced signal strength by reasonably controlling the taper lengths of the COTs. As a prototype, we constructed an actuator that generated ultrasound at four points with a balanced ultrasonic strength by connecting four COTs with coupling ratios of 24.5%, 33.01%, 49.51%, and 87.8% in a fiber link. This simple-to-fabricate, multipoint, laser-ultrasonic actuator with balanced ultrasound signal strength has potential applications in fiber-optic ultrasound testing technology.

Issues in providing a reliable multicast facility

NASA Technical Reports Server (NTRS)

Dempsey, Bert J.; Strayer, W. Timothy; Weaver, Alfred C.

1990-01-01

Issues involved in point-to-multipoint communication are presented and the literature for proposed solutions and approaches surveyed. Particular attention is focused on the ideas and implementations that align with the requirements of the environment of interest. The attributes of multicast receiver groups that might lead to useful classifications, what the functionality of a management scheme should be, and how the group management module can be implemented are examined. The services that multicasting facilities can offer are presented, followed by mechanisms within the communications protocol that implements these services. The metrics of interest when evaluating a reliable multicast facility are identified and applied to four transport layer protocols that incorporate reliable multicast.

Automated in Situ Measurement of Gas Solubility in Liquids with a Simple Tube-in-Tube Reactor.

PubMed

Zhang, Jisong; Teixeira, Andrew R; Zhang, Haomiao; Jensen, Klavs F

2017-08-15

Data on the solubilities of gases in liquids are foundational for assessing a variety of multiphase separations and gas-liquid reactions. Taking advantage of the tube-in-tube reactor design built with semipermeable Teflon AF-2400 tubes, liquids can be rapidly saturated without direct contacting of gas and liquid. The gas solubility can be determined by performing steady-state flux balances of both the gas and liquid flowing into the reactor system. Using this type of reactor, a fully automated strategy has been developed for the rapid in situ measurement of gas solubilities in liquids. The developed strategy enables precise gas solubility measurements within 2-5 min compared with 4-5 h using conventional methods. This technique can be extended to the discrete multipoint steady-state and continuous ramped-multipoint data acquisition methods. The accuracy of this method has been validated against several gas-liquid systems, showing less than 2% deviation from known values. Finally, this strategy has been extended to measure the temperature dependence of gas solubilities in situ and to estimate the local enthalpy of dissolution across a defined temperature range.

Investigating the use of multi-point coupling for single-sensor bearing estimation in one direction

NASA Astrophysics Data System (ADS)

Woolard, Americo G.; Phoenix, Austin A.; Tarazaga, Pablo A.

2018-04-01

Bearing estimation of radially propagating symmetric waves in solid structures typically requires a minimum of two sensors. As a test specimen, this research investigates the use of multi-point coupling to provide directional inference using a single-sensor. By this provision, the number of sensors required for localization can be reduced. A finite-element model of a beam is constructed with a symmetrically placed bipod that has asymmetric joint-stiffness properties. Impulse loading is applied at different points along the beam, and measurements are taken from the apex of the bipod. A technique is developed to determine the direction-of-arrival of the propagating wave. The accuracy when using the bipod with the developed technique is compared against results gathered without the bipod and measuring from an asymmetric location along the beam. The results show 92% accuracy when the bipod is used, compared to 75% when measuring without the bipod from an asymmetric location. A geometry investigation finds the best accuracy results when one leg of the bipod has a low stiffness and a large diameter relative to the other leg.

Multi-Gigabit Free-Space Optical Data Communication and Network System

DTIC Science & Technology

2016-04-01

IR), Ultraviolet ( UV ), Laser Transceiver, Adaptive Beam Tracking, Electronic Attack (EA), Cyber Attack, Multipoint-to-Multipoint Network, Adaptive...FileName.pptx Free Space Optical Datalink Timeline Phase 1 Point-to-point demonstration 2012 Future Adaptive optic & Quantum Cascade Laser

Distribution of Model-based Multipoint Heterogeneity Lod Scores

PubMed Central

Xing, Chao; Morris, Nathan; Xing, Guan

2011-01-01

The distribution of two-point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating the distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two-point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution 12χ02+12χ12, which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. PMID:21104892

Nance-Horan syndrome: linkage analysis in a family from The Netherlands.

PubMed

Bergen, A A; ten Brink, J; Schuurman, E J; Bleeker-Wagemakers, E M

1994-05-01

Linkage analysis was carried out in a Dutch family with Nance-Horan (NH) syndrome. Close linkage without recombination between NH and the Xp loci DXS207, DXS43, and DXS365 (zmax = 3.23) was observed. Multipoint linkage analysis and the analysis of recombinations in multiple informative meioses suggest the genetic order Xcen-DMD (exon 49)-DXS451-(NH, DXS207, DXS365, DXS43)-(STS, DXF30)-Xpter. These data refine the localization of the NH locus on the distal Xp.

On-board B-ISDN fast packet switching architectures. Phase 1: Study

NASA Technical Reports Server (NTRS)

Faris, Faris; Inukai, Thomas; Lee, Fred; Paul, Dilip; Shyy, Dong-Jye

1993-01-01

The broadband integrate services digital network (B-ISDN) is an emerging telecommunications technology that will meet most of the telecommunications networking needs in the mid-1990's to early next century. The satellite-based system is well positioned for providing B-ISDN service with its inherent capabilities of point-to-multipoint and broadcast transmission, virtually unlimited connectivity between any two points within a beam coverage, short deployment time of communications facility, flexible and dynamic reallocation of space segment capacity, and distance insensitive cost. On-board processing satellites, particularly in a multiple spot beam environment, will provide enhanced connectivity, better performance, optimized access and transmission link design, and lower user service cost. The following are described: the user and network aspects of broadband services; the current development status in broadband services; various satellite network architectures including system design issues; and various fast packet switch architectures and their detail designs.

Multipoint to multipoint routing and wavelength assignment in multi-domain optical networks

NASA Astrophysics Data System (ADS)

Qin, Panke; Wu, Jingru; Li, Xudong; Tang, Yongli

2018-01-01

In multi-point to multi-point (MP2MP) routing and wavelength assignment (RWA) problems, researchers usually assume the optical networks to be a single domain. However, the optical networks develop toward to multi-domain and larger scale in practice. In this context, multi-core shared tree (MST)-based MP2MP RWA are introduced problems including optimal multicast domain sequence selection, core nodes belonging in which domains and so on. In this letter, we focus on MST-based MP2MP RWA problems in multi-domain optical networks, mixed integer linear programming (MILP) formulations to optimally construct MP2MP multicast trees is presented. A heuristic algorithm base on network virtualization and weighted clustering algorithm (NV-WCA) is proposed. Simulation results show that, under different traffic patterns, the proposed algorithm achieves significant improvement on network resources occupation and multicast trees setup latency in contrast with the conventional algorithms which were proposed base on a single domain network environment.

Multipoint Observations of Energetic Particle Injections and Substorm Activity During a Conjunction Between Magnetospheric Multiscale (MMS) and Van Allen Probes

NASA Astrophysics Data System (ADS)

Turner, D. L.; Fennell, J. F.; Blake, J. B.; Claudepierre, S. G.; Clemmons, J. H.; Jaynes, A. N.; Leonard, T.; Baker, D. N.; Cohen, I. J.; Gkioulidou, M.; Ukhorskiy, A. Y.; Mauk, B. H.; Gabrielse, C.; Angelopoulos, V.; Strangeway, R. J.; Kletzing, C. A.; Le Contel, O.; Spence, H. E.; Torbert, R. B.; Burch, J. L.; Reeves, G. D.

2017-11-01

This study examines multipoint observations during a conjunction between Magnetospheric Multiscale (MMS) and Van Allen Probes on 7 April 2016 in which a series of energetic particle injections occurred. With complementary data from Time History of Events and Macroscale Interactions during Substorms, Geotail, and Los Alamos National Laboratory spacecraft in geosynchronous orbit (16 spacecraft in total), we develop new insights on the nature of energetic particle injections associated with substorm activity. Despite this case involving only weak substorm activity (maximum AE <300 nT) during quiet geomagnetic conditions in steady, below-average solar wind, a complex series of at least six different electron injections was observed throughout the system. Intriguingly, only one corresponding ion injection was clearly observed. All ion and electron injections were observed at <600 keV only. MMS reveals detailed substructure within the largest electron injection. A relationship between injected electrons with energy <60 keV and enhanced whistler mode chorus wave activity is also established from Van Allen Probes and MMS. Drift mapping using a simplified magnetic field model provides estimates of the dispersionless injection boundary locations as a function of universal time, magnetic local time, and L shell. The analysis reveals that at least five electron injections, which were localized in magnetic local time, preceded a larger injection of both electrons and ions across nearly the entire nightside of the magnetosphere near geosynchronous orbit. The larger ion and electron injection did not penetrate to L < 6.6, but several of the smaller electron injections penetrated to L < 6.6. Due to the discrepancy between the number, penetration depth, and complexity of electron versus ion injections, this event presents challenges to the current conceptual models of energetic particle injections.

Multipoint Observations of Energetic Particle Injections and Substorm Activity During a Conjunction Between Magnetospheric Multiscale (MMS) and Van Allen Probes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turner, Drew L.; Fennell, J. F.; Blake, J. B.

Here, this study examines multipoint observations during a conjunction between Magnetospheric Multiscale (MMS) and Van Allen Probes on 7 April 2016 in which a series of energetic particle injections occurred. With complementary data from Time History of Events and Macroscale Interactions during Substorms, Geotail, and Los Alamos National Laboratory spacecraft in geosynchronous orbit (16 spacecraft in total), we develop new insights on the nature of energetic particle injections associated with substorm activity. Despite this case involving only weak substorm activity (maximum AE <300 nT) during quiet geomagnetic conditions in steady, below-average solar wind, a complex series of at least sixmore » different electron injections was observed throughout the system. Intriguingly, only one corresponding ion injection was clearly observed. All ion and electron injections were observed at <600 keV only. MMS reveals detailed substructure within the largest electron injection. A relationship between injected electrons with energy <60 keV and enhanced whistler mode chorus wave activity is also established from Van Allen Probes and MMS. Drift mapping using a simplified magnetic field model provides estimates of the dispersionless injection boundary locations as a function of universal time, magnetic local time, and L shell. The analysis reveals that at least five electron injections, which were localized in magnetic local time, preceded a larger injection of both electrons and ions across nearly the entire nightside of the magnetosphere near geosynchronous orbit. The larger ion and electron injection did not penetrate to L < 6.6, but several of the smaller electron injections penetrated to L < 6.6. Due to the discrepancy between the number, penetration depth, and complexity of electron versus ion injections, this event presents challenges to the current conceptual models of energetic particle injections.« less

Multipoint Observations of Energetic Particle Injections and Substorm Activity During a Conjunction Between Magnetospheric Multiscale (MMS) and Van Allen Probes

DOE PAGES

Turner, Drew L.; Fennell, J. F.; Blake, J. B.; ...

2017-09-25

Here, this study examines multipoint observations during a conjunction between Magnetospheric Multiscale (MMS) and Van Allen Probes on 7 April 2016 in which a series of energetic particle injections occurred. With complementary data from Time History of Events and Macroscale Interactions during Substorms, Geotail, and Los Alamos National Laboratory spacecraft in geosynchronous orbit (16 spacecraft in total), we develop new insights on the nature of energetic particle injections associated with substorm activity. Despite this case involving only weak substorm activity (maximum AE <300 nT) during quiet geomagnetic conditions in steady, below-average solar wind, a complex series of at least sixmore » different electron injections was observed throughout the system. Intriguingly, only one corresponding ion injection was clearly observed. All ion and electron injections were observed at <600 keV only. MMS reveals detailed substructure within the largest electron injection. A relationship between injected electrons with energy <60 keV and enhanced whistler mode chorus wave activity is also established from Van Allen Probes and MMS. Drift mapping using a simplified magnetic field model provides estimates of the dispersionless injection boundary locations as a function of universal time, magnetic local time, and L shell. The analysis reveals that at least five electron injections, which were localized in magnetic local time, preceded a larger injection of both electrons and ions across nearly the entire nightside of the magnetosphere near geosynchronous orbit. The larger ion and electron injection did not penetrate to L < 6.6, but several of the smaller electron injections penetrated to L < 6.6. Due to the discrepancy between the number, penetration depth, and complexity of electron versus ion injections, this event presents challenges to the current conceptual models of energetic particle injections.« less

Distribution of model-based multipoint heterogeneity lod scores.

PubMed

Xing, Chao; Morris, Nathan; Xing, Guan

2010-12-01

The distribution of two-point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ(2) approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two-point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution ½χ²₀+ ½χ²₁, which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. © 2010 Wiley-Liss, Inc.

Public Data Set: Control and Automation of the Pegasus Multi-point Thomson Scattering System

DOE Data Explorer

Bodner, Grant M. [University of Wisconsin-Madison] (ORCID:0000000324979172); Bongard, Michael W. [University of Wisconsin-Madison] (ORCID:0000000231609746); Fonck, Raymond J. [University of Wisconsin-Madison] (ORCID:0000000294386762); Reusch, Joshua A. [University of Wisconsin-Madison] (ORCID:0000000284249422); Rodriguez Sanchez, Cuauhtemoc [University of Wisconsin-Madison] (ORCID:0000000334712586); Schlossberg, David J. [University of Wisconsin-Madison] (ORCID:0000000287139448)

2016-08-12

This public data set contains openly-documented, machine readable digital research data corresponding to figures published in G.M. Bodner et al., 'Control and Automation of the Pegasus Multi-point Thomson Scattering System,' Rev. Sci. Instrum. 87, 11E523 (2016).

Prompt enhancement of the Earth's outer radiation belt due to substorm electron injections

DOE PAGES

Tang, C. L.; Zhang, J. -C.; Reeves, G. D.; ...

2016-12-17

Here, we present multipoint simultaneous observations of the near-Earth magnetotail and outer radiation belt during the substorm electron injection event on 16 August 2013. Time History of Events and Macroscale Interactions during Substorms A in the near-Earth magnetotail observed flux-enhanced electrons of 300 keV during the magnetic field dipolarization. Geosynchronous orbit satellites also observed the intensive electron injections. Located in the outer radiation belt, RBSP-A observed enhancements of MeV electrons accompanied by substorm dipolarization. The phase space density (PSD) of MeV electrons at L* ~5.4 increased by 1 order of magnitude in 1 h, resulting in a local PSD peakmore » of MeV electrons, which was caused by the direct effect of substorm injections. We also detected an enhanced MeV electrons in the heart of the outer radiation belt within 2 h, which may be associated with intensive substorm electron injections and subsequent local acceleration by chorus waves. Multipoint observations have shown that substorm electron injections not only can be the external source of MeV electrons at the outer edge of the outer radiation belt (L* ~5.4) but also can provide the intensive seed populations in the outer radiation belt. These initial higher-energy electrons from injection can reach relativistic energy much faster. Furthermore, these observations also provide evidence that enhanced substorm electron injections can explain rapid enhancements of MeV electrons in the outer radiation belt.« less

Prompt enhancement of the Earth's outer radiation belt due to substorm electron injections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, C. L.; Zhang, J. -C.; Reeves, G. D.

Here, we present multipoint simultaneous observations of the near-Earth magnetotail and outer radiation belt during the substorm electron injection event on 16 August 2013. Time History of Events and Macroscale Interactions during Substorms A in the near-Earth magnetotail observed flux-enhanced electrons of 300 keV during the magnetic field dipolarization. Geosynchronous orbit satellites also observed the intensive electron injections. Located in the outer radiation belt, RBSP-A observed enhancements of MeV electrons accompanied by substorm dipolarization. The phase space density (PSD) of MeV electrons at L* ~5.4 increased by 1 order of magnitude in 1 h, resulting in a local PSD peakmore » of MeV electrons, which was caused by the direct effect of substorm injections. We also detected an enhanced MeV electrons in the heart of the outer radiation belt within 2 h, which may be associated with intensive substorm electron injections and subsequent local acceleration by chorus waves. Multipoint observations have shown that substorm electron injections not only can be the external source of MeV electrons at the outer edge of the outer radiation belt (L* ~5.4) but also can provide the intensive seed populations in the outer radiation belt. These initial higher-energy electrons from injection can reach relativistic energy much faster. Furthermore, these observations also provide evidence that enhanced substorm electron injections can explain rapid enhancements of MeV electrons in the outer radiation belt.« less

Identification of candidate regions for a novel Usher syndrome type II locus.

PubMed

Ben Rebeh, Imen; Benzina, Zeineb; Dhouib, Houria; Hadjamor, Imen; Amyere, Mustapha; Ayadi, Leila; Turki, Khalil; Hammami, Bouthaina; Kmiha, Noureddine; Kammoun, Hassen; Hakim, Bochra; Charfedine, Ilhem; Vikkula, Miikka; Ghorbel, Abdelmonem; Ayadi, Hammadi; Masmoudi, Saber

2008-09-19

Chronic diseases affecting the inner ear and the retina cause severe impairments to our communication systems. In more than half of the cases, Usher syndrome (USH) is the origin of these double defects. Patients with USH type II (USH2) have retinitis pigmentosa (RP) that develops during puberty, moderate to severe hearing impairment with downsloping pure-tone audiogram, and normal vestibular function. Four loci and three genes are known for USH2. In this study, we proposed to localize the gene responsible for USH2 in a consanguineous family of Tunisian origin. Affected members underwent detailed ocular and audiologic characterization. One Tunisian family with USH2 and 45 healthy controls unrelated to the family were recruited. Two affected and six unaffected family members attended our study. DNA samples of eight family members were genotyped with polymorphic markers. Two-point and multipoint LOD scores were calculated using Genehunter software v2.1. Sequencing was used to investigate candidate genes. Haplotype analysis showed no significant linkage to any known USH gene or locus. A genome-wide screen, using microsatellite markers, was performed, allowing the identification of three homozygous regions in chromosomes 2, 4, and 15. We further confirmed and refined these three regions using microsatellite and single-nucleotide polymorphisms. With recessive mode of inheritance, the highest multipoint LOD score of 1.765 was identified for the candidate regions on chromosomes 4 and 15. The chromosome 15 locus is large (55 Mb), underscoring the limited number of meioses in the consanguineous pedigree. Moreover, the linked, homozygous chromosome 15q alleles, unlike those of the chromosome 2 and 4 loci, are infrequent in the local population. Thus, the data strongly suggest that the novel locus for USH2 is likely to reside on 15q. Our data provide a basis for the localization and the identification of a novel gene implicated in USH2, most likely localized on 15q.

Order reduction of z-transfer functions via multipoint Jordan continued-fraction expansion

NASA Technical Reports Server (NTRS)

Lee, Ying-Chin; Hwang, Chyi; Shieh, Leang S.

1992-01-01

The order reduction problem of z-transfer functions is solved by using the multipoint Jordan continued-fraction expansion (MJCFE) technique. An efficient algorithm that does not require the use of complex algebra is presented for obtaining an MJCFE from a stable z-transfer function with expansion points selected from the unit circle and/or the positive real axis of the z-plane. The reduced-order models are exactly the multipoint Pade approximants of the original system and, therefore, they match the (weighted) time-moments of the impulse response and preserve the frequency responses of the system at some characteristic frequencies, such as gain crossover frequency, phase crossover frequency, bandwidth, etc.

Multi-Point E-Conferencing with Initial Teacher Training Students in England: Pitfalls and Potential

ERIC Educational Resources Information Center

Pratt, Nick

2008-01-01

This article reports on attempts to initiate multi-point e-conferencing between English teacher education students on school placements, their host teachers and their university tutors. A sociocultural perspective is adopted in analysing the project, using the metaphor of a "professional knowledge landscape" [Clandinin, D. J., &…

Public Data Set: A Novel, Cost-Effective, Multi-Point Thomson Scattering System on the Pegasus Toroidal Experiment

DOE Data Explorer

Schlossberg, David J. [University of Wisconsin-Madison] (ORCID:0000000287139448); Bodner, Grant M. [University of Wisconsin-Madison] (ORCID:0000000324979172); Reusch, Joshua A. [University of Wisconsin-Madison] (ORCID:0000000284249422); Bongard, Michael W. [University of Wisconsin-Madison] (ORCID:0000000231609746); Fonck, Raymond J. [University of Wisconsin-Madison] (ORCID:0000000294386762); Rodriguez Sanchez, Cuauhtemoc [University of Wisconsin-Madison] (ORCID:0000000334712586)

2016-09-16

This public data set contains openly-documented, machine readable digital research data corresponding to figures published in D.J. Schlossberg et. al., 'A Novel, Cost-Effective, Multi-Point Thomson Scattering System on the Pegasus Toroidal Experiment,' Rev. Sci. Instrum. 87, 11E403 (2016).

Multipoint Multimedia Conferencing System with Group Awareness Support and Remote Management

ERIC Educational Resources Information Center

Osawa, Noritaka; Asai, Kikuo

2008-01-01

A multipoint, multimedia conferencing system called FocusShare is described that uses IPv6/IPv4 multicasting for real-time collaboration, enabling video, audio, and group awareness information to be shared. Multiple telepointers provide group awareness information and make it easy to share attention and intention. In addition to pointing with the…

Improved method to fully compensate the spatial phase nonuniformity of LCoS devices with a Fizeau interferometer.

PubMed

Lu, Qiang; Sheng, Lei; Zeng, Fei; Gao, Shijie; Qiao, Yanfeng

2016-10-01

Liquid crystal on silicon (LCoS) devices usually show spatial phase nonuniformity (SPNU) in applications of phase modulation, which comprises the phase retardance nonuniformity (PRNU) as a function of the applied voltage and inherent wavefront distortion (WFD) introduced by the device itself. We propose a multipoint calibration method utilizing a Fizeau interferometer to compensate SPNU of the device. Calibration of PRNU is realized by defining a grid of 3×6 cells onto the aperture and then calculating phase retardance of each cell versus a gradient gray pattern. With designing an adjusted gray pattern calculated by the calibrated multipoint phase retardance function, compensation of inherent WFD is achieved. The peak-to-valley (PV) value of the residual WFD compensated by the multipoint calibration method is significantly reduced from 2.5λ to 0.140λ, while the PV value of the residual WFD after global calibration is reduced to 0.364λ. Experimental results of the generated finite-energy 2D Airy beams in Fourier space demonstrate the effectiveness of this multipoint calibration method.

Localized spiraling plasma ejection contributing the ion-flux broadening in the detached linear plasma

NASA Astrophysics Data System (ADS)

Tanaka, H.; Takeyama, K.; Yoshikawa, M.; Kajita, S.; Ohno, N.; Hayashi, Y.

2018-07-01

We have performed multipoint measurements with segmented electrodes and a microwave interferometer in the linear plasma device NAGDIS-II, in order to reveal cross-field motion and axial localization of the enhanced radial transport in the detached plasma. By changing the neutral pressure successively and applying several statistical analysis techniques, it was clarified that there is axially localized ion flux broadening accompanying an enhanced plasma ejection from the center with radially elongated spiraling structure. The spiraling plasma ejection accompanies the m = 0 mode drop near the center with the similar time scale. Further, such behavior composed of f > 1 kHz fluctuations is modulated by several-hundred-hertz fluctuation with m = 0. This cross-field transport causes non-negligible effect for the reduction of the ion flux peak in the detached plasma.

National Fusion Collaboratory: Grid Computing for Simulations and Experiments

NASA Astrophysics Data System (ADS)

Greenwald, Martin

2004-05-01

The National Fusion Collaboratory Project is creating a computational grid designed to advance scientific understanding and innovation in magnetic fusion research by facilitating collaborations, enabling more effective integration of experiments, theory and modeling and allowing more efficient use of experimental facilities. The philosophy of FusionGrid is that data, codes, analysis routines, visualization tools, and communication tools should be thought of as network available services, easily used by the fusion scientist. In such an environment, access to services is stressed rather than portability. By building on a foundation of established computer science toolkits, deployment time can be minimized. These services all share the same basic infrastructure that allows for secure authentication and resource authorization which allows stakeholders to control their own resources such as computers, data and experiments. Code developers can control intellectual property, and fair use of shared resources can be demonstrated and controlled. A key goal is to shield scientific users from the implementation details such that transparency and ease-of-use are maximized. The first FusionGrid service deployed was the TRANSP code, a widely used tool for transport analysis. Tools for run preparation, submission, monitoring and management have been developed and shared among a wide user base. This approach saves user sites from the laborious effort of maintaining such a large and complex code while at the same time reducing the burden on the development team by avoiding the need to support a large number of heterogeneous installations. Shared visualization and A/V tools are being developed and deployed to enhance long-distance collaborations. These include desktop versions of the Access Grid, a highly capable multi-point remote conferencing tool and capabilities for sharing displays and analysis tools over local and wide-area networks.

Use of three-point taper systems in timber cruising

Treesearch

James W. Flewelling; Richard L. Ernst; Lawrence M. Raynes

2000-01-01

Tree volumes and profiles are often estimated as functions of total height and DBH. Alternative estimators include form-class methods, importance sampling, the centroid method, and multi-point profile (taper) estimation systems; all of these require some measurement or estimate of upper stem diameters. The multi-point profile system discussed here allows for upper stem...

Instructor Interaction and Immediacy Behaviors in a Multipoint Videoconferenced Instructional Environment: A Descriptive Case Study

ERIC Educational Resources Information Center

Bohnstedt, Kathy D.

2011-01-01

The purpose of this study was to examine the experiences of professors teaching in a multi-point videoconferencing instructional environment and how they interacted with students in proximate and remote classrooms. Qualitative and quantitative data were analyzed to gain an understanding of the teaching experience and to examine differences between…

Fluid sample collection and distribution system. [qualitative analysis of aqueous samples from several points

NASA Technical Reports Server (NTRS)

Brooks, R. L. (Inventor)

1979-01-01

A multipoint fluid sample collection and distribution system is provided wherein the sample inputs are made through one or more of a number of sampling valves to a progressive cavity pump which is not susceptible to damage by large unfiltered particles. The pump output is through a filter unit that can provide a filtered multipoint sample. An unfiltered multipoint sample is also provided. An effluent sample can be taken and applied to a second progressive cavity pump for pumping to a filter unit that can provide one or more filtered effluent samples. The second pump can also provide an unfiltered effluent sample. Means are provided to periodically back flush each filter unit without shutting off the whole system.

Single-Pulse Multi-Point Multi-Component Interferometric Rayleigh Scattering Velocimeter

NASA Technical Reports Server (NTRS)

Bivolaru, Daniel; Danehy, Paul M.; Lee, Joseph W.; Gaffney, Richard L., Jr.; Cutler, Andrew D.

2006-01-01

A simultaneous multi-point, multi-component velocimeter using interferometric detection of the Doppler shift of Rayleigh, Mie, and Rayleigh-Brillouin scattered light in supersonic flow is described. The system uses up to three sets of collection optics and one beam combiner for the reference laser light to form a single collimated beam. The planar Fabry-Perot interferometer used in the imaging mode for frequency detection preserves the spatial distribution of the signal reasonably well. Single-pulse multi-points measurements of up to two orthogonal and one non-orthogonal components of velocity in a Mach 2 free jet were performed to demonstrate the technique. The average velocity measurements show a close agreement with the CFD calculations using the VULCAN code.

Multipoint propagators in cosmological gravitational instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernardeau, Francis; Crocce, Martin; Scoccimarro, Roman

2008-11-15

We introduce the concept of multipoint propagators between linear cosmic fields and their nonlinear counterparts in the context of cosmological perturbation theory. Such functions express how a nonlinearly evolved Fourier mode depends on the full ensemble of modes in the initial density field. We identify and resum the dominant diagrams in the large-k limit, showing explicitly that multipoint propagators decay into the nonlinear regime at the same rate as the two-point propagator. These analytic results generalize the large-k limit behavior of the two-point propagator to arbitrary order. We measure the three-point propagator as a function of triangle shape in numericalmore » simulations and confirm the results of our high-k resummation. We show that any n-point spectrum can be reconstructed from multipoint propagators, which leads to a physical connection between nonlinear corrections to the power spectrum at small scales and higher-order correlations at large scales. As a first application of these results, we calculate the reduced bispectrum at one loop in renormalized perturbation theory and show that we can predict the decrease in its dependence on triangle shape at redshift zero, when standard perturbation theory is least successful.« less

Use of near-infrared spectroscopy and multipoint measurements for quality control of pharmaceutical drug products.

PubMed

Boiret, Mathieu; Chauchard, Fabien

2017-01-01

Near-infrared (NIR) spectroscopy is a non-destructive analytical technique that enables better-understanding and optimization of pharmaceutical processes and final drug products. The use in line is often limited by acquisition speed and sampling area. This work focuses on performing a multipoint measurement at high acquisition speed at the end of the manufacturing process on a conveyor belt system to control both the distribution and the content of active pharmaceutical ingredient within final drug products, i.e., tablets. A specially designed probe with several collection fibers was developed for this study. By measuring spectral and spatial information, it provides physical and chemical knowledge on the final drug product. The NIR probe was installed on a conveyor belt system that enables the analysis of a lot of tablets. The use of these NIR multipoint measurement probes on a conveyor belt system provided an innovative method that has the potential to be used as a new paradigm to ensure the drug product quality at the end of the manufacturing process and as a new analytical method for the real-time release control strategy. Graphical abstract Use of near-infrared spectroscopy and multipoint measurements for quality control of pharmaceutical drug products.

Unbundling in Current Broadband and Next-Generation Ultra-Broadband Access Networks

NASA Astrophysics Data System (ADS)

Gaudino, Roberto; Giuliano, Romeo; Mazzenga, Franco; Valcarenghi, Luca; Vatalaro, Francesco

2014-05-01

This article overviews the methods that are currently under investigation for implementing multi-operator open-access/shared-access techniques in next-generation access ultra-broadband architectures, starting from the traditional "unbundling-of-the-local-loop" techniques implemented in legacy twisted-pair digital subscriber line access networks. A straightforward replication of these copper-based unbundling-of-the-local-loop techniques is usually not feasible on next-generation access networks, including fiber-to-the-home point-to-multipoint passive optical networks. To investigate this issue, the article first gives a concise description of traditional copper-based unbundling-of-the-local-loop solutions, then focalizes on both next-generation access hybrid fiber-copper digital subscriber line fiber-to-the-cabinet scenarios and on fiber to the home by accounting for the mix of regulatory and technological reasons driving the next-generation access migration path, focusing mostly on the European situation.

Multi-component quantitation of meso/nanostructural surfaces and its application to local chemical compositions of copper meso/nanostructures self-organized on silica

NASA Astrophysics Data System (ADS)

Huang, Chun-Yi; Chang, Hsin-Wei; Chang, Che-Chen

2018-03-01

Knowledge about the chemical compositions of meso/nanomaterials is fundamental to development of their applications in advanced technologies. Auger electron spectroscopy (AES) is an effective analysis method for the characterization of meso/nanomaterial structures. Although a few studies have reported the use of AES for the analysis of the local composition of these structures, none have explored in detail the validity of the meso/nanoanalysis results generated by the AES instrument. This paper addresses the limitations of AES and the corrections necessary to offset them for this otherwise powerful meso/nanoanalysis tool. The results of corrections made to the AES multi-point analysis of high-density copper-based meso/nanostructures provides major insights into their local chemical compositions and technological prospects, which the primitive composition output of the AES instrument failed to provide.

Integrated Sensing Using DNA Nanoarchitectures

DTIC Science & Technology

2014-05-20

Norton. Thiolated Dendrimers as Multi-Point Binding Headgroups for DNA Immobilization on Gold, Langmuir, (10 2011): 0. doi: 10.1021/la202444s...Figure 6, uses dendrimers to provide multipoint adhesion of a single stranded DNA component on a surface. Figure 6 Process for immobilizing... dendrimer (shown as a round species). These dendrimer species are Generation 3 PAMAM dendrimers with ~ 30 thiol groups to bind the dendrimer /DNA construct

Stability analysis of multipoint tool equipped with metal cutting ceramics

NASA Astrophysics Data System (ADS)

Maksarov, V. V.; Khalimonenko, A. D.; Matrenichev, K. G.

2017-10-01

The article highlights the issues of determining the stability of the cutting process by a multipoint cutting tool equipped with cutting ceramics. There were some recommendations offered on the choice of parameters of replaceable cutting ceramic plates for milling based of the conducted researches. Ceramic plates for milling are proposed to be selected on the basis of value of their electrical volume resistivity.

The gene for creatine kinase, mitochondrial 2 (sarcomeric; CKMT2), maps to chromosome 5q13. 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richard, I.; Devaud, C.; Cherif, D.

1993-10-01

YAC clones for the creatine kinase, mitochrondial 2 (sarcomeric; CKMT2), gene were isolated. One of these YACs was localized on chromosome 5q13.3 by fluorescence in situ hybridization. A polymorphic dinucleotide repeat (heterozygosity 0.77) was identified within the seventh intron of the CKMT2 gene. Genotyping of CEPH families allowed positioning of CKMT2 on the multipoint map of chromosome 5 between D5S424 and D5S428, distal to spinal muscular atrophy (SMA) (5q12-q14). 8 refs., 1 fig., 2 tabs.

Non-military microwave applications

NASA Astrophysics Data System (ADS)

Bierman, Howard

1990-04-01

The nonmilitary applications of microwave technology in medicine, communications, and agriculture are discussed. Particular attention is given to a microwave multichannel multipoint video distribution system (a broadcasting system with up to 20 programs drawn from satellites, video tape libraries, and locally generated material); microwaves used in DBS distribution; satellite receivers for data communications; microwave thermography used for early cancer detection, brain temperature measurements, and appendicitis diagnosis; an experimental Doppler radar assembly for guiding robots walking on a factory floor; and an agricultural application where microwaves are used to break down slugs in soil and thus improve potato and grain crops. Schematic diagrams are included.

Warehouse multipoint temperature and humidity monitoring system design based on Kingview

NASA Astrophysics Data System (ADS)

Ou, Yanghui; Wang, Xifu; Liu, Jingyun

2017-04-01

Storage is the key link of modern logistics. Warehouse environment monitoring is an important part of storage safety management. To meet the storage requirements of different materials, guarantee their quality in the greatest extent, which has great significance. In the warehouse environment monitoring, the most important parameters are air temperature and relative humidity. In this paper, a design of warehouse multipoint temperature and humidity monitoring system based on King view, which realizes the multipoint temperature and humidity data real-time acquisition, monitoring and storage in warehouse by using temperature and humidity sensor. Also, this paper will take the bulk grain warehouse as an example and based on the data collected in real-time monitoring, giving the corresponding expert advice that combined with the corresponding algorithm, providing theoretical guidance to control the temperature and humidity in grain warehouse.

A Robust Distributed Multipoint Fiber Optic Gas Sensor System Based on AGC Amplifier Structure.

PubMed

Zhu, Cunguang; Wang, Rende; Tao, Xuechen; Wang, Guangwei; Wang, Pengpeng

2016-07-28

A harsh environment-oriented distributed multipoint fiber optic gas sensor system realized by automatic gain control (AGC) technology is proposed. To improve the photoelectric signal reliability, the electronic variable gain can be modified in real time by an AGC closed-loop feedback structure to compensate for optical transmission loss which is caused by the fiber bend loss or other reasons. The deviation of the system based on AGC structure is below 4.02% when photoelectric signal decays due to fiber bending loss for bending radius of 5 mm, which is 20 times lower than the ordinary differential system. In addition, the AGC circuit with the same electric parameters can keep the baseline intensity of signals in different channels of the distributed multipoint sensor system at the same level. This avoids repetitive calibrations and streamlines the installation process.

Public Data Set: Erratum: "Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment" [Rev. Sci. Instrum. 83, 10D516 (2012)

DOE Data Explorer

Burke, Marcus G. [University of Wisconsin-Madison] (ORCID:0000000176193724); Fonck, Raymond J. [University of Wisconsin-Madison] (ORCID:0000000294386762); Bongard, Michael W. [University of Wisconsin-Madison] (ORCID:0000000231609746); Schlossberg, David J. [University of Wisconsin-Madison] (ORCID:0000000287139448); Winz, Gregory R. [University of Wisconsin-Madison] (ORCID:0000000177627184)

2016-07-18

This data set contains openly-documented, machine readable digital research data corresponding to figures published in M.G. Burke et al., 'Erratum: "Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment" [Rev. Sci. Instrum. 83, 10D516 (2012)],' Rev. Sci. Instrum. 87, 079902 (2016).

Reliable Wireless Broadcast with Linear Network Coding for Multipoint-to-Multipoint Real-Time Communications

NASA Astrophysics Data System (ADS)

Kondo, Yoshihisa; Yomo, Hiroyuki; Yamaguchi, Shinji; Davis, Peter; Miura, Ryu; Obana, Sadao; Sampei, Seiichi

This paper proposes multipoint-to-multipoint (MPtoMP) real-time broadcast transmission using network coding for ad-hoc networks like video game networks. We aim to achieve highly reliable MPtoMP broadcasting using IEEE 802.11 media access control (MAC) that does not include a retransmission mechanism. When each node detects packets from the other nodes in a sequence, the correctly detected packets are network-encoded, and the encoded packet is broadcasted in the next sequence as a piggy-back for its native packet. To prevent increase of overhead in each packet due to piggy-back packet transmission, network coding vector for each node is exchanged between all nodes in the negotiation phase. Each user keeps using the same coding vector generated in the negotiation phase, and only coding information that represents which user signal is included in the network coding process is transmitted along with the piggy-back packet. Our simulation results show that the proposed method can provide higher reliability than other schemes using multi point relay (MPR) or redundant transmissions such as forward error correction (FEC). We also implement the proposed method in a wireless testbed, and show that the proposed method achieves high reliability in a real-world environment with a practical degree of complexity when installed on current wireless devices.

Site-specific multipoint fluorescence measurement system with end-capped optical fibers.

PubMed

Song, Woosub; Moon, Sucbei; Lee, Byoung-Cheol; Park, Chul-Seung; Kim, Dug Young; Kwon, Hyuk Sang

2011-07-10

We present the development and implementation of a spatially and spectrally resolved multipoint fluorescence correlation spectroscopy (FCS) system utilizing multiple end-capped optical fibers and an inexpensive laser source. Specially prepared end-capped optical fibers placed in an image plane were used to both collect fluorescence signals from the sample and to deliver signals to the detectors. The placement of independently selected optical fibers on the image plane was done by monitoring the end-capped fiber tips at the focus using a CCD, and fluorescence from specific positions of a sample were collected by an end-capped fiber, which could accurately represent light intensities or spectral data without incurring any disturbance. A fast multipoint spectroscopy system with a time resolution of ∼1.5 ms was then implemented using a prism and an electron multiplying charge coupled device with a pixel binning for the region of interest. The accuracy of our proposed system was subsequently confirmed by experimental results, based on an FCS analysis of microspheres in distilled water. We expect that the proposed multipoint site-specific fluorescence measurement system can be used as an inexpensive fluorescence measurement tool to study many intracellular and molecular dynamics in cell biology. © 2011 Optical Society of America

Local multipoint distribution system (LDMS) versus free-space optical (FSO) networks

NASA Astrophysics Data System (ADS)

Willebrand, Heinz A.; Clark, Gerald R.; Willson, Bryan; Andreu von Euw, Christian G.; Roy, Joe; Mayhew, Laurel M.

2001-11-01

This paper compares two emerging broadband access methodologies, Free Space Optics (FSO) and Local Multipoint Distribution System (LMDS) and the atmospheric propagation characteristics of each when exposed to a dynamically changing channel. The comparison focuses on bandwidth, availability, and distance requirements for the new broadband market and how LMDS and FSO can be used to meet these requirements. Possible network topologies and their associated costs are examined. This comparison takes into account the total cost of deployment, including equipment costs, installation fees, access fees, and spectrum licensing fees. LMDS and FSO are compared on speed of deployment, scalability, aggregate bandwidth, and bandwidth per customer. Present and projected capabilities of each technology are considered for their suitability in different locations in the network, from the Wide Area Network (WAN), to the Metropolitan Area Network (MAN), all the way to Last Mile Access. There is a discussion on the relative performance of LMDS and FSO, focusing on the different factors that can affect link availability. Since network design is a large factor in assuring overall reliability, the flexibility of each technology with regard to network design is compared. LMDS and FSO are both line of sight, space-propagated technologies, and as such, they are both susceptible to path impediments and atmospheric attenuation, dispersion, scattering, and absorption. LMDS and FSO are affected very differently by different meteorological phenomena. Problematic atmospheric conditions are, specifically scintillation, rainfall, and fog, are examined. In addition to a discussion of these conditions, various techniques for minimizing atmospheric and environmental effects are investigated. The paper concludes with a summary of findings and recommendations for a number of broadband wireless applications.

Localization of a gene (CMT2A) for autosomal dominant Charcot-Marie-Tooth disease type 2 to chromosome 1p and evidence of genetic heterogeneity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Othmane, K.B.; Loprest, L.J.; Wilkinson, K.M.

1993-08-01

Charcot-Marie-Tooth (CMT) disease type 2 (CMT2) is an inherited peripheral neuropathy characterized by variable age of onset and normal or slightly diminished nerve conduction velocity. CMT2 is pathologically and genetically distinct from CMT type 1 (CMT1). While CMT1 has been shown to be genetically heterogeneous, no chromosomal localization has been established for CMT2. The authors have performed pedigree linkage analysis in six large autosomal dominant CMT2 families and have demonstrated linkage and heterogeneity to a series of microsatellites (D1S160, D1S170, D1S244, D1S228 and D1S199) in the distal region of the short arm of chromosome 1. Significant evidence for heterogeneity wasmore » found using admixture analyses and the two-point lod scores. Admixture analyses using the multipoint results for the markers D1S244, D1S228, and D1S199 supported the two-point findings. Three families, DUK662, DUK1241, and 1523 gave posterior probabilities of 1.0, 0.98, and 0.88 of being of the linked type. Multipoint analysis examining the [open quotes]linked[close quotes] families showed that the most favored location for the CMT2A gene is within the interval flanked by D1S244 and D1S228 (odds approximately 70:1 of lying within versus outside that interval). These findings suggest that the CMT2 phenotype is secondary to at least two different genes and demonstrate further heterogeneity in the CMT phenotype.« less

A canonical state-space representation for SISO systems using multipoint Jordan CFE. [Continued-Fraction Expansion

NASA Technical Reports Server (NTRS)

Hwang, Chyi; Guo, Tong-Yi; Shieh, Leang-San

1991-01-01

A canonical state-space realization based on the multipoint Jordan continued-fraction expansion (CFE) is presented for single-input-single-output (SISO) systems. The similarity transformation matrix which relates the new canonical form to the phase-variable canonical form is also derived. The presented canonical state-space representation is particularly attractive for the application of SISO system theory in which a reduced-dimensional time-domain model is necessary.

Satellite owners move to offset telephony losses to optical fiber

NASA Astrophysics Data System (ADS)

Lowndes, J. C.

1985-02-01

Preparations are made to exploit the advantages of communications satellites for distributing messages among many locations at once. By providing such services, it would be possible to offset losses in telephone market share, which are expected during the last half of the decade because of optical fiber competition. If the ventures in point-to-multipoint communications are successful, satellites can be employed to extend the full range of telecommunications services to many ground stations in suburban, rural, and even remote areas. In connection with current technological developments, it appears that optical fiber or digital microwave will replace satellites later in this decade on many long-haul routes with heavy traffic. An American telephone company plans to construct 21,000 miles of optical fiber facilities connecting U.S. cities and spanning the Atlantic and Pacific by the end of the decade.

STE/ICE (Simplified Test Equipment/Internal Combustion Engines) Design Guide for Vehicle Diagnostic Connector Assemblies

DTIC Science & Technology

1982-08-01

19 3.2 Diesel Engine Speed Transducer 20 3.3 Pressure Transducer 20 3.4 Temperature Transducer 22 3.5 Differential Pressure Switch 22 3.6 Differential... Pressure Switch , Multi-Point 22 3.7 Current Measurement Transducer 23 - 3.8 Electrolyte Level Probes 23 3.9 Diagnostic Connector 24 3.10 Harness...12258933 Differential Pressure Switch - Multi-point 12258934 K -. Differential Pressure Switch 12258938 Electrolyte Level Sensor 12258935 Shunt 1000

Traceability of pH measurements by glass electrode cells: performance characteristic of pH electrodes by multi-point calibration.

PubMed

Naumann, R; Alexander-Weber, Ch; Eberhardt, R; Giera, J; Spitzer, P

2002-11-01

Routine pH measurements are carried out with pH meter-glass electrode assemblies. In most cases the glass and reference electrodes are thereby fashioned into a single probe, the so-called 'combination electrode' or simply 'the pH electrode'. The use of these electrodes is subject to various effects, described below, producing uncertainties of unknown magnitude. Therefore, the measurement of pH of a sample requires a suitable calibration by certified standard buffer solutions (CRMs) traceable to primary pH standards. The procedures in use are based on calibrations at one point, at two points bracketing the sample pH and at a series of points, the so-called multi-point calibration. The multi-point calibration (MPC) is recommended if minimum uncertainty and maximum consistency are required over a wide range of unknown pH values. Details of uncertainty computations for the two-point and MPC procedure are given. Furthermore, the multi-point calibration is a useful tool to characterise the performance of pH electrodes. This is demonstrated with different commercial pH electrodes. ELECTRONIC SUPPLEMENTARY MATERIAL is available if you access this article at http://dx.doi.org/10.1007/s00216-002-1506-5. On that page (frame on the left side), a link takes you directly to the supplementary material.

The network and transmission of based on the principle of laser multipoint communication

NASA Astrophysics Data System (ADS)

Fu, Qiang; Liu, Xianzhu; Jiang, Huilin; Hu, Yuan; Jiang, Lun

2014-11-01

Space laser communication is the perfectly choose to the earth integrated information backbone network in the future. This paper introduces the structure of the earth integrated information network that is a large capacity integrated high-speed broadband information network, a variety of communications platforms were densely interconnected together, such as the land, sea, air and deep air users or aircraft, the technologies of the intelligent high-speed processing, switching and routing were adopt. According to the principle of maximum effective comprehensive utilization of information resources, get accurately information, fast processing and efficient transmission through inter-satellite, satellite earth, sky and ground station and other links. Namely it will be a space-based, air-based and ground-based integrated information network. It will be started from the trends of laser communication. The current situation of laser multi-point communications were expounded, the transmission scheme of the dynamic multi-point between wireless laser communication n network has been carefully studied, a variety of laser communication network transmission schemes the corresponding characteristics and scope described in detail , described the optical multiplexer machine that based on the multiport form of communication is applied to relay backbone link; the optical multiplexer-based on the form of the segmentation receiver field of view is applied to small angle link, the optical multiplexer-based form of three concentric spheres structure is applied to short distances, motorized occasions, and the multi-point stitching structure based on the rotation paraboloid is applied to inter-satellite communications in detail. The multi-point laser communication terminal apparatus consist of the transmitting and receiving antenna, a relay optical system, the spectroscopic system, communication system and communication receiver transmitter system. The communication forms of optical multiplexer more than four goals or more, the ratio of received power and volume weight will be Obvious advantages, and can track multiple moving targets in flexible.It would to provide reference for the construction of earth integrated information networks.

Multipoint Geospace Science in 3D: The Paired Ionosphere-Thermosphere Orbiters(PITO) Mission

NASA Technical Reports Server (NTRS)

Clemmons, J.; Walterscheid, R.; Nigg, D.; Judnick, D.; Lang, J.; Spann, J.

2010-01-01

The science enabled by the Paired Ionosphere-Thermosphere Orbiters (PITO) mission is described and discussed. PITO has been designed to provide the concurrent, three-dimensional, multipoint measurements needed to advance geospace science while staying within a stringent resource envelope. The mission utilizes a pair of orbiting vehicles in eccentric, high-inclination, coplanar orbits. The orbits have arguments of perigee that differ by 180 degrees and are phased such that one vehicle is at perigee (200 km) while the second is at apogee (2000 km). Half an orbit later, the vehicles switch positions. Three complementary types of measurements exploit this scenario: local, in-situ measurements on both satellites, two-dimensional imaging from the higher satellite, and vertical sounders. The main idea is that two-dimensional context information for the low-altitude measurements is obtained by the high altitude imagers, while information on the third dimension is provided by vertical profiling. Such an observation system is capable of providing elements of global coverage, regional coverage, and concurrent coverage in three dimensions. Science goals are presented, as are the results of a detailed implementation plan, including several trade studies on key elements of the mission. The conclusion is that the mission would enable significant new understanding of the ionosphere-thermosphere system within a resource envelope that is consistent with that of NASA's Medium Explorer (MIDEX) line of science missions.

Building America Case Study: Sealed Crawl Spaces with Integrated Whole-House Ventilation in a Cold Climate, Ithaca, New York

DOE Office of Scientific and Technical Information (OSTI.GOV)

"9One method of code-compliance for crawlspaces is to seal and insulate the crawlspace, rather than venting to the outdoors. However, codes require mechanical ventilation; either via conditioned supply air from the HVAC system, or a continuous exhaust ventilation strategy. As the CARB's building partner, Ithaca Neighborhood Housing Services, intended to use the unvented crawlspace in a recent development, CARB was interested in investigating a hybrid ventilation method that includes the exhaust air from the crawlspace as a portion of an ASHRAE 62.2 compliant whole-house ventilation strategy. This hybrid ventilation method was evaluated through a series of long-term monitoring tests thatmore » observed temperature, humidity, and pressure conditions through the home and crawlspace. Additionally, CARB worked with NREL to perform multi-point tracer gas testing on six separate ventilation strategies - varying portions of 62.2 required flow supplied by the crawlspace fan and an upstairs bathroom fan. The intent of the tracer gas testing was to identify effective Reciprocal Age of Air (RAoA), which is equivalent to the air change rate in well-mixed zones, for each strategy while characterizing localized infiltration rates in several areas of the home.« less

A hybrid integrated services digital network-internet protocol solution for resident education.

PubMed

Erickson, Delnora; Greer, Lester; Belard, Arnaud; Tinnel, Brent; O'Connell, John

2010-05-01

The purpose of this study was to explore the effectiveness of incorporating Web-based application sharing of virtual medical simulation software within a multipoint video teleconference (VTC) as a training tool in graduate medical education. National Capital Consortium Radiation Oncology Residency Program resident and attending physicians participated in dosimetry teaching sessions held via VTC using Acrobat Connect application sharing. Residents at remote locations could take turns designing radiation treatments using standard three-dimensional planning software, whereas instructors gave immediate feedback and demonstrated proper techniques. Immediately after each dosimetry lesson, residents were asked to complete a survey that evaluated the effectiveness of the session. At the end of a 3-month trial of using Adobe Connect, residents completed a final survey that compared this teaching technology to the prior VTC-alone method. The mean difference from equality across all quality measures from the weekly survey was 0.8, where 0 indicated neither enhanced nor detracted from the learning experience and 1 indicated a minor enhancement in the learning experience. The mean difference from equality across all measures from the final survey comparing use of application sharing with VTC to VTC alone was 1.5, where 1 indicated slightly better and 2 indicated a somewhat better experience. The teaching efficacy of multipoint VTC is perceived by medical residents to be more effective when complemented by application-sharing software such as Adobe Acrobat Connect.

Scalar discrete nonlinear multipoint boundary value problems

NASA Astrophysics Data System (ADS)

Rodriguez, Jesus; Taylor, Padraic

2007-06-01

In this paper we provide sufficient conditions for the existence of solutions to scalar discrete nonlinear multipoint boundary value problems. By allowing more general boundary conditions and by imposing less restrictions on the nonlinearities, we obtain results that extend previous work in the area of discrete boundary value problems [Debra L. Etheridge, Jesus Rodriguez, Periodic solutions of nonlinear discrete-time systems, Appl. Anal. 62 (1996) 119-137; Debra L. Etheridge, Jesus Rodriguez, Scalar discrete nonlinear two-point boundary value problems, J. Difference Equ. Appl. 4 (1998) 127-144].

Recent Results from NASA's Morphing Project

NASA Technical Reports Server (NTRS)

McGowan, Anna-Maria R.; Washburn, Anthony E.; Horta, Lucas G.; Bryant, Robert G.; Cox, David E.; Siochi, Emilie J.; Padula, Sharon L.; Holloway, Nancy M.

2002-01-01

The NASA Morphing Project seeks to develop and assess advanced technologies and integrated component concepts to enable efficient, multi-point adaptability in air and space vehicles. In the context of the project, the word "morphing" is defined as "efficient, multi-point adaptability" and may include macro, micro, structural and/or fluidic approaches. The project includes research on smart materials, adaptive structures, micro flow control, biomimetic concepts, optimization and controls. This paper presents an updated overview of the content of the Morphing Project including highlights of recent research results.

[Linkage analysis of susceptibility loci in 2 target chromosomes in pedigrees with paranoid schizophrenia and undifferentiated schizophrenia].

PubMed

Zeng, Li-ping; Hu, Zheng-mao; Mu, Li-li; Mei, Gui-sen; Lu, Xiu-ling; Zheng, Yong-jun; Li, Pei-jian; Zhang, Ying-xue; Pan, Qian; Long, Zhi-gao; Dai, He-ping; Zhang, Zhuo-hua; Xia, Jia-hui; Zhao, Jing-ping; Xia, Kun

2011-06-01

To investigate the relationship of susceptibility loci in chromosomes 1q21-25 and 6p21-25 and schizophrenia subtypes in Chinese population. A genomic scan and parametric and non-parametric analyses were performed on 242 individuals from 36 schizophrenia pedigrees, including 19 paranoid schizophrenia and 17 undifferentiated schizophrenia pedigrees, from Henan province of China using 5 microsatellite markers in the chromosome region 1q21-25 and 8 microsatellite markers in the chromosome region 6p21-25, which were the candidates of previous studies. All affected subjects were diagnosed and typed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revised (DSM-IV-TR; American Psychiatric Association, 2000). All subjects signed informed consent. In chromosome 1, parametric analysis under the dominant inheritance mode of all 36 pedigrees showed that the maximum multi-point heterogeneity Log of odds score method (HLOD) score was 1.33 (α = 0.38). The non-parametric analysis and the single point and multi-point nonparametric linkage (NPL) scores suggested linkage at D1S484, D1S2878, and D1S196. In the 19 paranoid schizophrenias pedigrees, linkage was not observed for any of the 5 markers. In the 17 undifferentiated schizophrenia pedigrees, the multi-point NPL score was 1.60 (P= 0.0367) at D1S484. The single point NPL score was 1.95(P= 0.0145) and the multi-point NPL score was 2.39 (P= 0.0041) at D1S2878. Additionally, the multi-point NPL score was 1.74 (P= 0.0255) at D1S196. These same three loci showed suggestive linkage during the integrative analysis of all 36 pedigrees. In chromosome 6, parametric linkage analysis under the dominant and recessive inheritance and the non-parametric linkage analysis of all 36 pedigrees and the 17 undifferentiated schizophrenia pedigrees, linkage was not observed for any of the 8 markers. In the 19 paranoid schizophrenias pedigrees, parametric analysis showed that under recessive inheritance mode the maximum single-point HLOD score was 1.26 (α = 0.40) and the multi-point HLOD was 1.12 (α = 0.38) at D6S289 in the chromosome 6p23. In nonparametric analysis, the single-point NPL score was 1.52 (P= 0.0402) and the multi-point NPL score was 1.92 (P= 0.0206) at D6S289. Susceptibility genes correlated with undifferentiated schizophrenia pedigrees from D1S484, D1S2878, D1S196 loci, and those correlated with paranoid schizophrenia pedigrees from D6S289 locus are likely present in chromosome regions 1q23.3 and 1q24.2, and chromosome region 6p23, respectively.

Extraction of repetitive transients with frequency domain multipoint kurtosis for bearing fault diagnosis

NASA Astrophysics Data System (ADS)

Liao, Yuhe; Sun, Peng; Wang, Baoxiang; Qu, Lei

2018-05-01

The appearance of repetitive transients in a vibration signal is one typical feature of faulty rolling element bearings. However, accurate extraction of these fault-related characteristic components has always been a challenging task, especially when there is interference from large amplitude impulsive noises. A frequency domain multipoint kurtosis (FDMK)-based fault diagnosis method is proposed in this paper. The multipoint kurtosis is redefined in the frequency domain and the computational accuracy is improved. An envelope autocorrelation function is also presented to estimate the fault characteristic frequency, which is used to set the frequency hunting zone of the FDMK. Then, the FDMK, instead of kurtosis, is utilized to generate a fast kurtogram and only the optimal band with maximum FDMK value is selected for envelope analysis. Negative interference from both large amplitude impulsive noise and shaft rotational speed related harmonic components are therefore greatly reduced. The analysis results of simulation and experimental data verify the capability and feasibility of this FDMK-based method

Numerical Solution of Systems of Loaded Ordinary Differential Equations with Multipoint Conditions

NASA Astrophysics Data System (ADS)

Assanova, A. T.; Imanchiyev, A. E.; Kadirbayeva, Zh. M.

2018-04-01

A system of loaded ordinary differential equations with multipoint conditions is considered. The problem under study is reduced to an equivalent boundary value problem for a system of ordinary differential equations with parameters. A system of linear algebraic equations for the parameters is constructed using the matrices of the loaded terms and the multipoint condition. The conditions for the unique solvability and well-posedness of the original problem are established in terms of the matrix made up of the coefficients of the system of linear algebraic equations. The coefficients and the righthand side of the constructed system are determined by solving Cauchy problems for linear ordinary differential equations. The solutions of the system are found in terms of the values of the desired function at the initial points of subintervals. The parametrization method is numerically implemented using the fourth-order accurate Runge-Kutta method as applied to the Cauchy problems for ordinary differential equations. The performance of the constructed numerical algorithms is illustrated by examples.

Localization of A Novel Autosomal Recessive Non-Syndromic Hearing Impairment Locus (DFNB38) to 6q26–q27 in a Consanguineous Kindred from Pakistan

PubMed Central

Ansar, Muhammad; Ramzan, Mohammad; Pham, Thanh L.; Yan, Kai; Jamal, Syed Muhammad; Haque, Sayedul; Ahmad, Wasim; Leal, Suzanne M.

2010-01-01

For autosomal recessive nonsyndromic hearing impairment over 30 loci have been mapped and 19 genes have been identified. DFNB38, a novel locus for autosomal recessive nonsyndromic hearing impairment, was localized in a consanguineous Pakistani kindred to 6q26–q27. The affected family members present with profound prelingual sensorineural hearing impairment and use sign language for communications. Linkage was established to microsatellite markers located on chromosome 6q26–q27 (Multipoint lod score 3.6). The genetic region for DFNB38 spans 10.1 cM according to the Marshfield genetic map and is bounded by markers D6S980 and D6S1719. This genetic region corresponds to 3.4 MB on the sequence-based physical map. PMID:12890929

Nonlinear inversion of potential-field data using a hybrid-encoding genetic algorithm

USGS Publications Warehouse

Chen, C.; Xia, J.; Liu, J.; Feng, G.

2006-01-01

Using a genetic algorithm to solve an inverse problem of complex nonlinear geophysical equations is advantageous because it does not require computer gradients of models or "good" initial models. The multi-point search of a genetic algorithm makes it easier to find the globally optimal solution while avoiding falling into a local extremum. As is the case in other optimization approaches, the search efficiency for a genetic algorithm is vital in finding desired solutions successfully in a multi-dimensional model space. A binary-encoding genetic algorithm is hardly ever used to resolve an optimization problem such as a simple geophysical inversion with only three unknowns. The encoding mechanism, genetic operators, and population size of the genetic algorithm greatly affect search processes in the evolution. It is clear that improved operators and proper population size promote the convergence. Nevertheless, not all genetic operations perform perfectly while searching under either a uniform binary or a decimal encoding system. With the binary encoding mechanism, the crossover scheme may produce more new individuals than with the decimal encoding. On the other hand, the mutation scheme in a decimal encoding system will create new genes larger in scope than those in the binary encoding. This paper discusses approaches of exploiting the search potential of genetic operations in the two encoding systems and presents an approach with a hybrid-encoding mechanism, multi-point crossover, and dynamic population size for geophysical inversion. We present a method that is based on the routine in which the mutation operation is conducted in the decimal code and multi-point crossover operation in the binary code. The mix-encoding algorithm is called the hybrid-encoding genetic algorithm (HEGA). HEGA provides better genes with a higher probability by a mutation operator and improves genetic algorithms in resolving complicated geophysical inverse problems. Another significant result is that final solution is determined by the average model derived from multiple trials instead of one computation due to the randomness in a genetic algorithm procedure. These advantages were demonstrated by synthetic and real-world examples of inversion of potential-field data. ?? 2005 Elsevier Ltd. All rights reserved.

In-line multipoint near-infrared spectroscopy for moisture content quantification during freeze-drying.

PubMed

Kauppinen, Ari; Toiviainen, Maunu; Korhonen, Ossi; Aaltonen, Jaakko; Järvinen, Kristiina; Paaso, Janne; Juuti, Mikko; Ketolainen, Jarkko

2013-02-19

During the past decade, near-infrared (NIR) spectroscopy has been applied for in-line moisture content quantification during a freeze-drying process. However, NIR has been used as a single-vial technique and thus is not representative of the entire batch. This has been considered as one of the main barriers for NIR spectroscopy becoming widely used in process analytical technology (PAT) for freeze-drying. Clearly it would be essential to monitor samples that reliably represent the whole batch. The present study evaluated multipoint NIR spectroscopy for in-line moisture content quantification during a freeze-drying process. Aqueous sucrose solutions were used as model formulations. NIR data was calibrated to predict the moisture content using partial least-squares (PLS) regression with Karl Fischer titration being used as a reference method. PLS calibrations resulted in root-mean-square error of prediction (RMSEP) values lower than 0.13%. Three noncontact, diffuse reflectance NIR probe heads were positioned on the freeze-dryer shelf to measure the moisture content in a noninvasive manner, through the side of the glass vials. The results showed that the detection of unequal sublimation rates within a freeze-dryer shelf was possible with the multipoint NIR system in use. Furthermore, in-line moisture content quantification was reliable especially toward the end of the process. These findings indicate that the use of multipoint NIR spectroscopy can achieve representative quantification of moisture content and hence a drying end point determination to a desired residual moisture level.

P2MP MPLS-Based Hierarchical Service Management System

NASA Astrophysics Data System (ADS)

Kumaki, Kenji; Nakagawa, Ikuo; Nagami, Kenichi; Ogishi, Tomohiko; Ano, Shigehiro

This paper proposes a point-to-multipoint (P2MP) Multi-Protocol Label Switching (MPLS) based hierarchical service management system. Traditionally, general management systems deployed in some service providers control MPLS Label Switched Paths (LSPs) (e.g., RSVP-TE and LDP) and services (e.g., L2VPN, L3VPN and IP) separately. In order for dedicated management systems for MPLS LSPs and services to cooperate with each other automatically, a hierarchical service management system has been proposed with the main focus on point-to-point (P2P) TE LSPs in MPLS path management. In the case where P2MP TE LSPs and services are deployed in MPLS networks, the dedicated management systems for P2MP TE LSPs and services must work together automatically. Therefore, this paper proposes a new algorithm that uses a correlation between P2MP TE LSPs and multicast VPN services based on a P2MP MPLS-based hierarchical service management architecture. Also, the capacity and performance of the proposed algorithm are evaluated by simulations, which are actually based on certain real MPLS production networks, and are compared to that of the algorithm for P2P TE LSPs. Results show this system is very scalable within real MPLS production networks. This system, with the automatic correlation, appears to be deployable in real MPLS production networks.

Multipoint Green's functions in 1 + 1 dimensional integrable quantum field theories

DOE PAGES

Babujian, H. M.; Karowski, M.; Tsvelik, A. M.

2017-02-14

We calculate the multipoint Green functions in 1+1 dimensional integrable quantum field theories. We use the crossing formula for general models and calculate the 3 and 4 point functions taking in to account only the lower nontrivial intermediate states contributions. Then we apply the general results to the examples of the scaling Z 2 Ising model, sinh-Gordon model and Z 3 scaling Potts model. We demonstrate this calculations explicitly. The results can be applied to physical phenomena as for example to the Raman scattering.

Satellite economics in the 1980's

NASA Astrophysics Data System (ADS)

Morgan, W. L.

1980-01-01

Satellite traffic, competition, and decreasing costs are discussed, as are capabilities in telecommunication (including entertainment) and computation. Also considered are future teleconferencing and telecommuting to offset the cost of transportation, the establishment of a manufacturer-to-user link for increased home minicomputer capability, and an increase of digital over analog traffic. It is suggested that transcontinental bulk traffic, high-speed data, and multipoint private networks will eventually be handled by satellites which are cost-insensitive to distance, readily match dynamically varying multipoint networks, and have uniformly wide bandwidths available to both major cities and isolated towns.

Multi-Point Combustion System: Final Report

NASA Technical Reports Server (NTRS)

Goeke, Jerry; Pack, Spencer; Zink, Gregory; Ryon, Jason

2014-01-01

A low-NOx emission combustor concept has been developed for NASA's Environmentally Responsible Aircraft (ERA) program to meet N+2 emissions goals for a 70,000 lb thrust engine application. These goals include 75 percent reduction of LTO NOx from CAEP6 standards without increasing CO, UHC, or smoke from that of current state of the art. An additional key factor in this work is to improve lean combustion stability over that of previous work performed on similar technology in the early 2000s. The purpose of this paper is to present the final report for the NASA contract. This work included the design, analysis, and test of a multi-point combustion system. All design work was based on the results of Computational Fluid Dynamics modeling with the end results tested on a medium pressure combustion rig at the UC and a medium pressure combustion rig at GRC. The theories behind the designs, results of analysis, and experimental test data will be discussed in this report. The combustion system consists of five radially staged rows of injectors, where ten small scale injectors are used in place of a single traditional nozzle. Major accomplishments of the current work include the design of a Multipoint Lean Direct Injection (MLDI) array and associated air blast and pilot fuel injectors, which is expected to meet or exceed the goal of a 75 percent reduction in LTO NOx from CAEP6 standards. This design incorporates a reduced number of injectors over previous multipoint designs, simplified and lightweight components, and a very compact combustor section. Additional outcomes of the program are validation that the design of these combustion systems can be aided by the use of Computational Fluid Dynamics to predict and reduce emissions. Furthermore, the staging of fuel through the individually controlled radially staged injector rows successfully demonstrated improved low power operability as well as improvements in emissions over previous multipoint designs. Additional comparison between Jet- A fuel and a hydrotreated biofuel is made to determine viability of the technology for use with alternative fuels. Finally, the operability of the array and associated nozzles proved to be very stable without requiring additional active or passive control systems. A number of publications have been publish

Initial results from a multi-point mapping observation of thundercloud high-energy radiation in coastal area of Japan sea

NASA Astrophysics Data System (ADS)

Wada, Y.; Enoto, T.; Furuta, Y.; Nakazawa, K.; Yuasa, T.; Okuda, K.; Makishima, K.; Nakano, T.; Umemoto, D.; Tsuchiya, H.

2017-12-01

On-ground detections of Thunderstorm Radiation Bursts (TRB) which mainly consist of bremsstrahlung gamma rays with energy extending up to 20 MeV indicate powerful electron accelerations inside thunderclouds or along lightning discharge paths (e.g. Torii et al., 2002, Tsuchiya et al., 2007, Dwyer et al., 2004). In order to resolve time variation and structure of the electron accelerators, we have constructed a multi-point mapping observation network with the aim of tracing gamma rays from moving thunderclouds since 2015. In fiscal 2016, we developed low cost and small size detectors dedicated to our observation. The data acquisition system records energy and timing of individual gamma-ray photons by 4-ch and 50 MHz sampling electrical boards (9.5 cm x 9.5 cm), coupled with BGO scintillator crystals. The systems were installed in portable water-proof boxes. We operated 10 detectors in two areas (Ishikawa and Niigata) along the coast of Japan Sea from October 2016 to April 2017. During this period, detectors in Ishikawa detected in total 10 TRBs lasting for several minutes associated with passage of a thundercloud. Our previous single-site measurement at Niigata, has recorded 1.4 TRBs per year on average in 2006-2015. Therefore, our new multi-point observation detected 7 times as many events as the previous system. One of the TRB gamma-ray spectra was fitted well by a cutoff power-law model. We performed a Monte Carlo simulation, and revealed that this spectrum was explained as bremsstrahlung of a monochromatic 15 MeV electron beam generated at an altitude of 500 m. We also succeeded in tracing gamma rays from an identical moving thundercloud with two detectors, demonstrating performance of the multi-point observation. In addition, we detected "short TRBs" lasting for a few hundred milliseconds associated with lightning discharges from four independent detectors placed 500 m apart simultaneously, in January and February 2017 at Niigata. The results in 2016-2017 winter season are proving that our multi-point observation can firmly detect a large number of TRBs and trace gamma rays from thunderstorms.

Comparison of clinical outcomes of multi-point umbrella suturing and single purse suturing with two-point traction after procedure for prolapse and hemorrhoids (PPH) surgery.

PubMed

Jiang, Huiyong; Hao, Xiuyan; Xin, Ying; Pan, Youzhen

2017-11-01

To compare the clinical outcomes of multipoint umbrella suture and single-purse suture with two-point traction after procedure for prolapse and hemorrhoids surgery (PPH) for the treatment of mixed hemorrhoids. Ninety patients were randomly divided into a PPH plus single-purse suture group (Group A) and a PPH plus multipoint umbrella suture (Group B). All operations were performed by an experienced surgeon. Operation time, width of the specimen, hemorrhoids retraction extent, postoperative pain, postoperative bleeding, and length of hospitalization were recorded and compared. Statistical analysis was conducted by t-test and χ2 test. There were no significant differences in sex, age, course of disease, and degree of prolapse of hemorrhoids between the two groups. The operative time in Group A was significantly shorter than that in Group B (P < 0.05). However, the incidence rates of submucosal hematoma and incomplete hemorrhoid core retraction were significantly lower in Group B (P < 0.05), whereas the width of the specimens in Group B was greater than that in Group A (P < 0.05). There were fewer redundant skin tags in Group B at three months follow-up. No significant difference in postoperative pain, postoperative bleeding, and time of hospital stay (P > 0.05 for all comparisons) was observed. The multipoint umbrella suture showed better clinical outcomes because of its targeted suture according to the extent of hemorrhoid prolapse. Copyright © 2017. Published by Elsevier Ltd.

Rapid and accurate peripheral nerve detection using multipoint Raman imaging (Conference Presentation)

NASA Astrophysics Data System (ADS)

Kumamoto, Yasuaki; Minamikawa, Takeo; Kawamura, Akinori; Matsumura, Junichi; Tsuda, Yuichiro; Ukon, Juichiro; Harada, Yoshinori; Tanaka, Hideo; Takamatsu, Tetsuro

2017-02-01

Nerve-sparing surgery is essential to avoid functional deficits of the limbs and organs. Raman scattering, a label-free, minimally invasive, and accurate modality, is one of the best candidate technologies to detect nerves for nerve-sparing surgery. However, Raman scattering imaging is too time-consuming to be employed in surgery. Here we present a rapid and accurate nerve visualization method using a multipoint Raman imaging technique that has enabled simultaneous spectra measurement from different locations (n=32) of a sample. Five sec is sufficient for measuring n=32 spectra with good S/N from a given tissue. Principal component regression discriminant analysis discriminated spectra obtained from peripheral nerves (n=863 from n=161 myelinated nerves) and connective tissue (n=828 from n=121 tendons) with sensitivity and specificity of 88.3% and 94.8%, respectively. To compensate the spatial information of a multipoint-Raman-derived tissue discrimination image that is too sparse to visualize nerve arrangement, we used morphological information obtained from a bright-field image. When merged with the sparse tissue discrimination image, a morphological image of a sample shows what portion of Raman measurement points in arbitrary structure is determined as nerve. Setting a nerve detection criterion on the portion of "nerve" points in the structure as 40% or more, myelinated nerves (n=161) and tendons (n=121) were discriminated with sensitivity and specificity of 97.5%. The presented technique utilizing a sparse multipoint Raman image and a bright-field image has enabled rapid, safe, and accurate detection of peripheral nerves.

Multi-point objective-oriented sequential sampling strategy for constrained robust design

NASA Astrophysics Data System (ADS)

Zhu, Ping; Zhang, Siliang; Chen, Wei

2015-03-01

Metamodelling techniques are widely used to approximate system responses of expensive simulation models. In association with the use of metamodels, objective-oriented sequential sampling methods have been demonstrated to be effective in balancing the need for searching an optimal solution versus reducing the metamodelling uncertainty. However, existing infilling criteria are developed for deterministic problems and restricted to one sampling point in one iteration. To exploit the use of multiple samples and identify the true robust solution in fewer iterations, a multi-point objective-oriented sequential sampling strategy is proposed for constrained robust design problems. In this article, earlier development of objective-oriented sequential sampling strategy for unconstrained robust design is first extended to constrained problems. Next, a double-loop multi-point sequential sampling strategy is developed. The proposed methods are validated using two mathematical examples followed by a highly nonlinear automotive crashworthiness design example. The results show that the proposed method can mitigate the effect of both metamodelling uncertainty and design uncertainty, and identify the robust design solution more efficiently than the single-point sequential sampling approach.

Capturing rogue waves by multi-point statistics

NASA Astrophysics Data System (ADS)

Hadjihosseini, A.; Wächter, Matthias; Hoffmann, N. P.; Peinke, J.

2016-01-01

As an example of a complex system with extreme events, we investigate ocean wave states exhibiting rogue waves. We present a statistical method of data analysis based on multi-point statistics which for the first time allows the grasping of extreme rogue wave events in a highly satisfactory statistical manner. The key to the success of the approach is mapping the complexity of multi-point data onto the statistics of hierarchically ordered height increments for different time scales, for which we can show that a stochastic cascade process with Markov properties is governed by a Fokker-Planck equation. Conditional probabilities as well as the Fokker-Planck equation itself can be estimated directly from the available observational data. With this stochastic description surrogate data sets can in turn be generated, which makes it possible to work out arbitrary statistical features of the complex sea state in general, and extreme rogue wave events in particular. The results also open up new perspectives for forecasting the occurrence probability of extreme rogue wave events, and even for forecasting the occurrence of individual rogue waves based on precursory dynamics.

Multipoint molecular recognition within a calix[6]arene funnel complex

PubMed Central

Coquière, David; de la Lande, Aurélien; Martí, Sergio; Parisel, Olivier; Prangé, Thierry; Reinaud, Olivia

2009-01-01

A multipoint recognition system based on a calix[6]arene is described. The calixarene core is decorated on alternating aromatic subunits by 3 imidazole arms at the small rim and 3 aniline groups at the large rim. This substitution pattern projects the aniline nitrogens toward each other when Zn(II) binds at the Tris-imidazole site or when a proton binds at an aniline. The XRD structure of the monoprotonated complex having an acetonitrile molecule bound to Zn(II) in the cavity revealed a constrained geometry at the metal center reminiscent of an entatic state. Computer modeling suggests that the aniline groups behave as a tritopic monobasic site in which only 1 aniline unit is protonated and interacts with the other 2 through strong hydrogen bonding. The metal complex selectively binds a monoprotonated diamine vs. a monoamine through multipoint recognition: coordination to the metal ion at the small rim, hydrogen bonding to the calix-oxygen core, CH/π interaction within the cavity's aromatic walls, and H-bonding to the anilines at the large rim. PMID:19237564

Multi-point estimation of total energy expenditure: a comparison between zinc-reduction and platinum-equilibration methodologies.

PubMed

Sonko, Bakary J; Miller, Leland V; Jones, Richard H; Donnelly, Joseph E; Jacobsen, Dennis J; Hill, James O; Fennessey, Paul V

2003-12-15

Reducing water to hydrogen gas by zinc or uranium metal for determining D/H ratio is both tedious and time consuming. This has forced most energy metabolism investigators to use the "two-point" technique instead of the "Multi-point" technique for estimating total energy expenditure (TEE). Recently, we purchased a new platinum (Pt)-equilibration system that significantly reduces both time and labor required for D/H ratio determination. In this study, we compared TEE obtained from nine overweight but healthy subjects, estimated using the traditional Zn-reduction method to that obtained from the new Pt-equilibration system. Rate constants, pool spaces, and CO2 production rates obtained from use of the two methodologies were not significantly different. Correlation analysis demonstrated that TEEs estimated using the two methods were significantly correlated (r=0.925, p=0.0001). Sample equilibration time was reduced by 66% compared to those of similar methods. The data demonstrated that the Zn-reduction method could be replaced by the Pt-equilibration method when TEE was estimated using the "Multi-Point" technique. Furthermore, D equilibration time was significantly reduced.

ISINGLASS campaign multi point sensors and data integration

NASA Astrophysics Data System (ADS)

Clayton, R.; Lynch, K. A.; Michell, R.; Hampton, D. L.; Samara, M.; Zettergren, M. D.; Hysell, D. L.; Lessard, M.

2016-12-01

The upcoming ISINGLASS mission will take place during February 2017 and will consist of 2 rockets launched out of Poker Flat Research Range, Alaska. Each rocket will deploy sensorcraft on the upleg to generate a localized multipoint measurement of the ionospheric plasma environment. Ground based measurements such as the PFISR and SuperDARN radar arrays, CCD cameras making maps of multi-wavelength energy flux and characteristic energy, and Scanning Doppler Imagers for neutral flows, will also be used in conjunction with the in situ rocket measurements. The GEMINI ionospheric model will be used to stitch together all of the various data products during the mission to provide a map of the relevant parameters during the duration of the campaign. The sensors built by Dartmouth for this mission are called Petite Ion Probes (PIPs), collimated RPAs with heritage on the MICA auroral mission. For the upcoming Isinglass flights, PIPs will be assembled into small ejectables, and four of these sensorcraft will be deployed from each of the two rockets on the upleg, creating a localized swarm for the duration of the flight through the F-region ionosphere. During the science portion of the flight, the sensorcraft will be spaced 1km apart from the main payload, which allows for the multipoint measurement of small-scale gradients in the F-region, such as across the edges of arcs. Interpretation of the data from the PIPs is aided by calibration done at Dartmouth in the Elephant plasma chamber. Comparison between the PIPs, and Langmuir and emissive probe measurements, provides verification of the PIP measurements, as well as verifying the field of view of the detector in the various configurations present on the payload. Observational goals for the campaign target a different type of auroral arc with each of the two rockets. The measured response of the thermal ionospheric plasma to different types and scale sizes of auroral precipitation drivers will provide two case studies quantifying the gradient scale lengths of auroral disturbances.

Linkage localization of X-linked Charcot-Marie-Tooth disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bergoffen, J.; Trofatter, J.; Haines, J.L.

1993-02-01

Charcot-Marie-Tooth disease (CMT), also known as hereditary motor and sensory neuropathy, is a heterogeneous group of slowly progressive, degenerative disorders of peripheral nerve. X-linked CMT (CMTX) (McKusick 302800), a subdivision of type I, or demyelinating, CMT is an X-linked dominant condition with variable penetrance. Previous linkage analysis using RFLPs demonstrated linkage to markers on the proximal long and short arms of the X chromosome, with the more likely localization on the proximal long arm of the X chromosome. Available variable simple-sequence repeats (VSSRs) broaden the possibilities for linkage analysis. This paper presents new linkage data and recombination analysis derived frommore » work with four VSSR markers - AR, PGKP1, DXS453, and DXYS1X - in addition to analysis using RFLP markers described elsewhere. These studies localize the CMTX gene to the proximal Xq segment between PGKP1 (Xq11.2-12) and DXS72 (Xq21.1), with a combined maximum multipoint lod score of 15.3 at DXS453 ([theta] = 0). 32 refs., 3 figs., 2 tabs.« less

Multipoint entanglement in disordered systems

NASA Astrophysics Data System (ADS)

Magán, Javier M.; Paganelli, Simone; Oganesyan, Vadim

2017-02-01

We develop an approach to characterize excited states of disordered many-body systems using spatially resolved structures of entanglement. We show that the behavior of the mutual information (MI) between two parties of a many-body system can signal a qualitative difference between thermal and localized phases - MI is finite in insulators while it approaches zero in the thermodynamic limit in the ergodic phase. Related quantities, such as the recently introduced Codification Volume (CV), are shown to be suitable to quantify the correlation length of the system. These ideas are illustrated using prototypical non-interacting wavefunctions of localized and extended particles and then applied to characterize states of strongly excited interacting spin chains. We especially focus on evolution of spatial structure of quantum information between high temperature diffusive and many-body localized (MBL) phases believed to exist in these models. We study MI as a function of disorder strength both averaged over the eigenstates and in time-evolved product states drawn from continuously deformed family of initial states realizable experimentally. As expected, spectral and time-evolved averages coincide inside the ergodic phase and differ significantly outside. We also highlight dispersion among the initial states within the localized phase - some of these show considerable generation and delocalization of quantum information.

Experimental investigation of the Multipoint Ultrasonic Flowmeter

NASA Astrophysics Data System (ADS)

Jakub, Filipský

2018-06-01

The Multipoint Ultrasonic Flowmeter is a vector tomographic device capable of reconstructing all three components of velocity field based solely on boundary ultrasonic measurements. Computer simulations have shown the feasibility of such a device and have been published previously. This paper describes an experimental investigation of achievable accuracy of such a method. Doubled acoustic tripoles used to obtain information of the solenoidal part of vector field show extremely short differences between the Time Of Flights (TOFs) of individual sensors and are therefore sensitive to parasitic effects of TOF measurements. Sampling at 40MHz and correlation method is used to measure the TOF.

Development and accuracy of a multipoint method for measuring visibility.

PubMed

Tai, Hongda; Zhuang, Zibo; Sun, Dongsong

2017-10-01

Accurate measurements of visibility are of great importance in many fields. This paper reports a multipoint visibility measurement (MVM) method to measure and calculate the atmospheric transmittance, extinction coefficient, and meteorological optical range (MOR). The relative errors of atmospheric transmittance and MOR measured by the MVM method and traditional transmissometer method are analyzed and compared. Experiments were conducted indoors, and the data were simultaneously processed. The results revealed that the MVM can effectively improve the accuracy under different visibility conditions. The greatest improvement of accuracy was 27%. The MVM can be used to calibrate and evaluate visibility meters.

Two-way digital communications

NASA Astrophysics Data System (ADS)

Glenn, William E.; Daly, Ed

1996-03-01

The communications industry has been rapidly converting from analog to digital communications for audio, video, and data. The initial applications have been concentrating on point-to-multipoint transmission. Currently, a new revolution is occurring in which two-way point-to-point transmission is a rapidly growing market. The system designs for video compression developed for point-to-multipoint transmission are unsuitable for this new market as well as for satellite based video encoding. A new system developed by the Space Communications Technology Center has been designed to address both of these newer applications. An update on the system performance and design will be given.

On the Interconnection of Incompatible Solid Finite Element Meshes Using Multipoint Constraints

NASA Technical Reports Server (NTRS)

Fox, G. L.

1985-01-01

Incompatible meshes, i.e., meshes that physically must have a common boundary, but do not necessarily have coincident grid points, can arise in the course of a finite element analysis. For example, two substructures may have been developed at different times for different purposes and it becomes necessary to interconnect the two models. A technique that uses only multipoint constraints, i.e., MPC cards (or MPCS cards in substructuring), is presented. Since the method uses only MPC's, the procedure may apply at any stage in an analysis; no prior planning or special data is necessary.

Multipoint attachment to a support protects enzyme from inactivation by organic solvents: alpha-Chymotrypsin in aqueous solutions of alcohols and diols.

PubMed

Mozhaev, V V; Sergeeva, M V; Belova, A B; Khmelnitsky, Y L

1990-03-25

Inactivation of alpha-chymotrypsin in aqueous solutions of alcohols and diols proceeds both reversibly and irreversibly. Reversible loss of the specific enzyme activity results from conformational changes (unfolding) of the enzyme detected by fluorescence spectroscopy. Multipoint covalent attachment to the matrix of polyacryl-amide gel by copolymerization method stabilizes alpha-chymotrypsin from denaturation by alcohols, the stabilizing effect increasing with the number of bonds between the protein and the support. Immobilization protects the enzyme also from irreversible inactivation by organic solvents resulting from bimolecular aggregation and autolysis.

An approach to efficient mobility management in intelligent networks

NASA Technical Reports Server (NTRS)

Murthy, K. M. S.

1995-01-01

Providing personal communication systems supporting full mobility require intelligent networks for tracking mobile users and facilitating outgoing and incoming calls over different physical and network environments. In realizing the intelligent network functionalities, databases play a major role. Currently proposed network architectures envision using the SS7-based signaling network for linking these DB's and also for interconnecting DB's with switches. If the network has to support ubiquitous, seamless mobile services, then it has to support additionally mobile application parts, viz., mobile origination calls, mobile destination calls, mobile location updates and inter-switch handovers. These functions will generate significant amount of data and require them to be transferred between databases (HLR, VLR) and switches (MSC's) very efficiently. In the future, the users (fixed or mobile) may use and communicate with sophisticated CPE's (e.g. multimedia, multipoint and multisession calls) which may require complex signaling functions. This will generate volumness service handling data and require efficient transfer of these message between databases and switches. Consequently, the network providers would be able to add new services and capabilities to their networks incrementally, quickly and cost-effectively.

Stray light analysis for the Thomson scattering diagnostic of the ETE Tokamak.

PubMed

Berni, L A; Albuquerque, B F C

2010-12-01

Thomson scattering is a well-established diagnostic for measuring local electron temperature and density in fusion plasma, but this technique is particularly difficult to implement due to stray light that can easily mask the scattered signal from plasma. To mitigate this problem in the multipoint Thomson scattering system implemented at the ETE (Experimento Tokamak Esférico) a detailed stray light analysis was performed. The diagnostic system was simulated in ZEMAX software and scattering profiles of the mechanical parts were measured in the laboratory in order to have near realistic results. From simulation, it was possible to identify the main points that contribute to the stray signals and changes in the dump were implemented reducing the stray light signals up to 60 times.

Serial network simplifies the design of multiple microcomputer systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Folkes, D.

1981-01-01

Recently there has been a lot of interest in developing network communication schemes for carrying digital data between locally distributed computing stations. Many of these schemes have focused on distributed networking techniques for data processing applications. These applications suggest the use of a serial, multipoint bus, where a number of remote intelligent units act as slaves to a central or host computer. Each slave would be serially addressable from the host and would perform required operations upon being addressed by the host. Based on an MK3873 single-chip microcomputer, the SCU 20 is designed to be such a remote slave device.more » The capabilities of the SCU 20 and its use in systems applications are examined.« less

Multi-Point Measurements to Characterize Radiation Belt Electron Precipitation Loss

NASA Astrophysics Data System (ADS)

Blum, L. W.

2017-12-01

Multipoint measurements in the inner magnetosphere allow the spatial and temporal evolution of various particle populations and wave modes to be disentangled. To better characterize and quantify radiation belt precipitation loss, we utilize multi-point measurements both to study precipitating electrons directly as well as the potential drivers of this loss process. Magnetically conjugate CubeSat and balloon measurements are combined to estimate of the temporal and spatial characteristics of dusk-side precipitation features and quantify loss due to these events. To then understand the drivers of precipitation events, and what determines their spatial structure, we utilize measurements from the dual Van Allen Probes to estimate spatial and temporal scales of various wave modes in the inner magnetosphere, and compare these to precipitation characteristics. The structure, timing, and spatial extent of waves are compared to those of MeV electron precipitation during a few individual events to determine when and where EMIC waves cause radiation belt electron precipitation. Magnetically conjugate measurements provide observational support of the theoretical picture of duskside interaction of EMIC waves and MeV electrons leading to radiation belt loss. Finally, understanding the drivers controlling the spatial scales of wave activity in the inner magnetosphere is critical for uncovering the underlying physics behind the wave generation as well as for better predicting where and when waves will be present. Again using multipoint measurements from the Van Allen Probes, we estimate the spatial and temporal extents and evolution of plasma structures and their gradients in the inner magnetosphere, to better understand the drivers of magnetospheric wave characteristic scales. In particular, we focus on EMIC waves and the plasma parameters important for their growth, namely cold plasma density and cool and warm ion density, anisotropy, and composition.

Optimization of bump and blowing to control the flow through a transonic compressor blade cascade

NASA Astrophysics Data System (ADS)

Mazaheri, K.; Khatibirad, S.

2018-03-01

Shock control bump (SCB) and blowing are two flow control methods, used here to improve the aerodynamic performance of transonic compressors. Both methods are applied to a NASA rotor 67 blade section and are optimized to minimize the total pressure loss. A continuous adjoint algorithm is used for multi-point optimization of a SCB to improve the aerodynamic performance of the rotor blade section, for a range of operational conditions around its design point. A multi-point and two single-point optimizations are performed in the design and off-design conditions. It is shown that the single-point optimized shapes have the best performance for their respective operating conditions, but the multi-point one has an overall better performance over the whole operating range. An analysis is given regarding how similarly both single- and multi-point optimized SCBs change the wave structure between blade sections resulting in a more favorable flow pattern. Interactions of the SCB with the boundary layer and the wave structure, and its effects on the separation regions are also studied. We have also introduced the concept of blowing for control of shock wave and boundary-layer interaction. A geometrical model is introduced, and the geometrical and physical parameters of blowing are optimized at the design point. The performance improvements of blowing are compared with the SCB. The physical interactions of SCB with the boundary layer and the shock wave are analyzed. The effects of SCB on the wave structure in the flow domain outside the boundary-layer region are investigated. It is shown that the effects of the blowing mechanism are very similar to the SCB.

Regulation of protein multipoint adsorption on ion-exchange adsorbent and its application to the purification of macromolecules.

PubMed

Huang, Yongdong; Bi, Jingxiu; Zhao, Lan; Ma, Guanghui; Su, Zhiguo

2010-12-01

Ion-exchange chromatography (IEC) using commercial ionic absorbents is a widely used technique for protein purification. Protein adsorption onto ion-exchange adsorbents often involves a multipoint adsorption. In IEC of multimeric proteins or "soft" proteins, the intense multipoint binding would make the further desorption difficult, even lead to the destruction of protein structure and the loss of its biological activity. In this paper, DEAE Sepharose FF adsorbents with controllable ligand densities from 0.020 to 0.183 mmol/ml were synthesized, and then the effect of ligand density on the static ion-exchange adsorption of bovine serum albumin (BSA) onto DEAE Sepharose FF was studied by batch adsorption technique. Steric mass-action (SMA) model was employed to analyze the static adsorption behavior. The results showed that the SMA model parameters, equilibrium constant (K(a)), characteristic number of binding sites (υ) and steric factor (σ), increased gradually with ligand density. Thus, it was feasible to regulate BSA multipoint adsorption by modulating the ligand density of ion-exchange adsorbent. Furthermore, IEC of hepatitis B surface antigen (HBsAg) using DEAE Sepharose FF adsorbents with different ligand densities was carried out, and the activity recovery of HBsAg was improved from 42% to 67% when the ligand density was decreased from 0.183 to 0.020 mmol/ml. Taking the activity recovery of HBsAg, the purification factor and the binding capacity into account, DEAE Sepharose FF with a ligand density of 0.041 mmol/ml was most effective for the purification of HBsAg. Such a strategy may also be beneficial for the purification of macromolecules and multimeric proteins. Copyright © 2010 Elsevier Inc. All rights reserved.

Implementation of a light-route TDMA communications satellite system for advanced business networks

NASA Astrophysics Data System (ADS)

Hanson, B.; Smalley, A.; Zuliani, M.

The application of Light Route TDMA systems to various business communication requirements is discussed. It is noted that full development of this technology for use in advanced business networks will be guided by considerations of flexibility, reliability, security, and cost. The implementation of the TDMA system for demonstrating these advantages to a wide range of public and private organizations is described in detail. Among the advantages offered by this system are point-to-point and point-to-multipoint (broadcast) capability; the ability to vary the mix and quantity of services between destinations in a fully connected mesh network on an almost instantaneous basis through software control; and enhanced reliability with centralized monitor, alarm and control functions by virtue of an overhead channel.

Genetic analysis of eight loci tightly linked to neurofibromatosis 1

PubMed Central

Stephens, Karen; Green, Philip; Riccardi, Vincent M.; Ng, Siu; Rising, Marcia; Barker, David; Darby, John K.; Falls, Kathleen M.; Collins, Francis S.; Willard, Huntington F.; Donis-Keller, Helen

1989-01-01

The genetic locus for neurofibromatosis 1 (NF1) has recently been mapped to the pericentromeric region of chromosome 17. We have genotyped eight previously identified RFLP probes on 50 NF1 families to determine the placement of the NF1 locus relative to the RFLP loci. Thirty-eight recombination events in the pericentromeric region were identified, eight involving crossovers between NF1 and loci on either chromosomal arm. Multipoint linkage analysis resulted in the unique placement of six loci at odds >100:1 in the order of pter–A10-41–EW301–NF1–EW207–CRI-L581–CRI-L946–qter. Owing to insufficient crossovers, three loci–D17Z1, EW206, and EW203–could not be uniquely localized. In this region female recombination rates were significantly higher than those of males. These data were part of a joint study aimed at the localization of both NF1 and tightly linked pericentromeric markers for chromosome 17. PMID:2491775

Refinement of the cone-rod retinal dystrophy locus on chromosome 19q

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gregory, C.Y.; Evans, K.; Bhattacharya, S.S.

1994-11-01

Cone-rod dystrophy (CRD) is a severe example of an inherited retinal dystrophy: ophthalmic diseases that as a group constitute the commonest causes of blindness in children in the developed world and account for a significant proportion of visual handicap in adults. Two case reports suggested loci for CRD-causing genes on chromosomes 18q and chromosome 17q. Recently, we reported the results of a total genome search that localized an autosomal dominant form of CRD to chromosome 19q in the region 19q13.1-q13.2. Since then, using data from a short tandem repeat-polymorphism linkage map of chromosome 19 and recently developed microsatellite markers inmore » this region, we have been able to further refine the localization of the chromosome 19q CRD-causing gene. Seven new microsatellite markers were used to genotype 34 affected subjects, 22 unaffected subjects, and 15 spouses. Two-point, multipoint, and FASTMAP analyses were performed. 11 refs., 1 tab.« less

Integrated Multi-Point Space Plasma Measurements With Four Ionospheric Satellites

NASA Astrophysics Data System (ADS)

Siefring, C. L.; Bernhardt, P. A.; Selcher, C.; Wilkens, M. R.; McHarg, M. G.; Krause, L.; Chun, F.; Enloe, L.; Panholzer, R.; Sakoda, D.; Phelps, R.; D Roussel-Dupre, D.; Colestock, P.; Close, S.

2006-12-01

The STP-1 launch scheduled for late 2006 will place four satellites with ionospheric plasma diagnostics into the same nearly circular orbit with an altitude of 560 km and inclination of 35.4°. The satellites will allow for unique multipoint measurements of ionospheric scintillations and their causes. Both the radio and in-situ diagnostics will provide coverage of low- and mid-latitudes. The four satellites, STPSat1, NPSat1, FalconSat3, and CFE will follow the same ground-track but because of drag and mass differences their relative velocities will be different and vary during the lifetime of the satellites. The four satellites will start close together; separate over a few months and coming back together with near conjunctions at six and eight months. Two satellite conjunctions between NPSat1 and STPSat1 will occur most often, approximately one month apart at the end of the mission. STPSat1 is equipped with CITRIS (sCintillation and TEC Receiver In Space) which will measure scintillations in the VHF, UHF and L-band along with measuring Total Electron Content (TEC) along the propagation path. NPSat1 will carry a three-frequency CERTO (Coherent Electromagnetic Radio TOmography) Beacon which broadcasts phase-coherent signals at 150.012 MHz, 400.032 MHz, and 1066.752 MHz. CITRIS will be able to measure TEC and Scintillations along the orbital path (propagation path from NPSat1 to STPSat1) as well as between the CITRIS and the ground. NPSat1 carries electron and ion saturation Langmuir Probes, while FalconSat3 carries the FLAPS (FLAt Plasma Spectrometer) and PLANE (Plasma Local Anomalous Noise Environment). The in-situ diagnostic complement the CITRIS/CERTO radio techniques in many ways. The CIBOLA Flight Experiment (CFE) contains a wide band receiver covering 100 to 500 MHz. The CFE data can be processed to show distortion of wide-band modulations by ionospheric irregularities. CFE and CITRIS can record ground transmissions from the French DORIS beacons which radiate at 401.25 and 2036.25 MHz. The multi-point techniques provide redundant measurements of radio scintillations and other ionospheric distortions. The causative density irregularities will be imaged using computerized ionospheric tomographic and inverse-diffraction algorithms. The STP-1 sensors in low-earth-orbit will relate electron and ion density fluctuations and radio scintillation effects over a wide range of frequencies. This research supported at NRL by ONR.

Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors.

PubMed

Sung, Yun Ju; Di, Yanming; Fu, Audrey Q; Rothstein, Joseph H; Sieh, Weiva; Tong, Liping; Thompson, Elizabeth A; Wijsman, Ellen M

2007-01-01

We performed multipoint linkage analyses with multiple programs and models for several gene expression traits in the Centre d'Etude du Polymorphisme Humain families. All analyses provided consistent results for both peak location and shape. Variance-components (VC) analysis gave wider peaks and Bayes factors gave fewer peaks. Among programs from the MORGAN package, lm_multiple performed better than lm_markers, resulting in less Markov-chain Monte Carlo (MCMC) variability between runs, and the program lm_twoqtl provided higher LOD scores by also including either a polygenic component or an additional quantitative trait locus.

Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors

PubMed Central

Sung, Yun Ju; Di, Yanming; Fu, Audrey Q; Rothstein, Joseph H; Sieh, Weiva; Tong, Liping; Thompson, Elizabeth A; Wijsman, Ellen M

2007-01-01

We performed multipoint linkage analyses with multiple programs and models for several gene expression traits in the Centre d'Etude du Polymorphisme Humain families. All analyses provided consistent results for both peak location and shape. Variance-components (VC) analysis gave wider peaks and Bayes factors gave fewer peaks. Among programs from the MORGAN package, lm_multiple performed better than lm_markers, resulting in less Markov-chain Monte Carlo (MCMC) variability between runs, and the program lm_twoqtl provided higher LOD scores by also including either a polygenic component or an additional quantitative trait locus. PMID:18466597

Space Technology 5 Multipoint Observations of Temporal and Spatial Variability of Field-Aligned Currents

NASA Technical Reports Server (NTRS)

Le, G.; Wang, Y.; Slavin, J. A.; Strangeway, R. L.

2009-01-01

Space Technology 5 (ST5) is a constellation mission consisting of three microsatellites. It provides the first multipoint magnetic field measurements in low Earth orbit, which enables us to separate spatial and temporal variations. In this paper, we present a study of the temporal variability of field-aligned currents using the ST5 data. We examine the field-aligned current observations during and after a geomagnetic storm and compare the magnetic field profiles at the three spacecraft. The multipoint data demonstrate that mesoscale current structures, commonly embedded within large-scale current sheets, are very dynamic with highly variable current density and/or polarity in approx.10 min time scales. On the other hand, the data also show that the time scales for the currents to be relatively stable are approx.1 min for mesoscale currents and approx.10 min for large-scale currents. These temporal features are very likely associated with dynamic variations of their charge carriers (mainly electrons) as they respond to the variations of the parallel electric field in auroral acceleration region. The characteristic time scales for the temporal variability of mesoscale field-aligned currents are found to be consistent with those of auroral parallel electric field.

Exploring microwave resonant multi-point ignition using high-speed schlieren imaging

NASA Astrophysics Data System (ADS)

Liu, Cheng; Zhang, Guixin; Xie, Hong; Deng, Lei; Wang, Zhi

2018-03-01

Microwave plasma offers a potential method to achieve rapid combustion in a high-speed combustor. In this paper, microwave resonant multi-point ignition and its control method have been studied via high-speed schlieren imaging. The experiment was conducted with the microwave resonant ignition system and the schlieren optical system. The microwave pulse in 2.45 GHz with 2 ms width and 3 kW peak power was employed as an ignition energy source to produce initial flame kernels in the combustion chamber. A reflective schlieren method was designed to illustrate the flame development process with a high-speed camera. The bottom of the combustion chamber was made of a quartz glass coated with indium tin oxide, which ensures sufficient microwave reflection and light penetration. Ignition experiments were conducted at 2 bars of stoichiometric methane-air mixtures. Schlieren images show that flame kernels were generated at more than one location simultaneously and flame propagated with different speeds in different flame kernels. Ignition kernels were discussed in three types according to their appearances. Pressure curves and combustion duration also show that multi-point ignition plays a significant role in accelerating combustion.

Online System for Faster Multipoint Linkage Analysis via Parallel Execution on Thousands of Personal Computers

PubMed Central

Silberstein, M.; Tzemach, A.; Dovgolevsky, N.; Fishelson, M.; Schuster, A.; Geiger, D.

2006-01-01

Computation of LOD scores is a valuable tool for mapping disease-susceptibility genes in the study of Mendelian and complex diseases. However, computation of exact multipoint likelihoods of large inbred pedigrees with extensive missing data is often beyond the capabilities of a single computer. We present a distributed system called “SUPERLINK-ONLINE,” for the computation of multipoint LOD scores of large inbred pedigrees. It achieves high performance via the efficient parallelization of the algorithms in SUPERLINK, a state-of-the-art serial program for these tasks, and through the use of the idle cycles of thousands of personal computers. The main algorithmic challenge has been to efficiently split a large task for distributed execution in a highly dynamic, nondedicated running environment. Notably, the system is available online, which allows computationally intensive analyses to be performed with no need for either the installation of software or the maintenance of a complicated distributed environment. As the system was being developed, it was extensively tested by collaborating medical centers worldwide on a variety of real data sets, some of which are presented in this article. PMID:16685644

Exploring microwave resonant multi-point ignition using high-speed schlieren imaging.

PubMed

Liu, Cheng; Zhang, Guixin; Xie, Hong; Deng, Lei; Wang, Zhi

2018-03-01

Microwave plasma offers a potential method to achieve rapid combustion in a high-speed combustor. In this paper, microwave resonant multi-point ignition and its control method have been studied via high-speed schlieren imaging. The experiment was conducted with the microwave resonant ignition system and the schlieren optical system. The microwave pulse in 2.45 GHz with 2 ms width and 3 kW peak power was employed as an ignition energy source to produce initial flame kernels in the combustion chamber. A reflective schlieren method was designed to illustrate the flame development process with a high-speed camera. The bottom of the combustion chamber was made of a quartz glass coated with indium tin oxide, which ensures sufficient microwave reflection and light penetration. Ignition experiments were conducted at 2 bars of stoichiometric methane-air mixtures. Schlieren images show that flame kernels were generated at more than one location simultaneously and flame propagated with different speeds in different flame kernels. Ignition kernels were discussed in three types according to their appearances. Pressure curves and combustion duration also show that multi-point ignition plays a significant role in accelerating combustion.

The sumLINK statistic for genetic linkage analysis in the presence of heterogeneity.

PubMed

Christensen, G B; Knight, S; Camp, N J

2009-11-01

We present the "sumLINK" statistic--the sum of multipoint LOD scores for the subset of pedigrees with nominally significant linkage evidence at a given locus--as an alternative to common methods to identify susceptibility loci in the presence of heterogeneity. We also suggest the "sumLOD" statistic (the sum of positive multipoint LOD scores) as a companion to the sumLINK. sumLINK analysis identifies genetic regions of extreme consistency across pedigrees without regard to negative evidence from unlinked or uninformative pedigrees. Significance is determined by an innovative permutation procedure based on genome shuffling that randomizes linkage information across pedigrees. This procedure for generating the empirical null distribution may be useful for other linkage-based statistics as well. Using 500 genome-wide analyses of simulated null data, we show that the genome shuffling procedure results in the correct type 1 error rates for both the sumLINK and sumLOD. The power of the statistics was tested using 100 sets of simulated genome-wide data from the alternative hypothesis from GAW13. Finally, we illustrate the statistics in an analysis of 190 aggressive prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics, where we identified a new susceptibility locus. We propose that the sumLINK and sumLOD are ideal for collaborative projects and meta-analyses, as they do not require any sharing of identifiable data between contributing institutions. Further, loci identified with the sumLINK have good potential for gene localization via statistical recombinant mapping, as, by definition, several linked pedigrees contribute to each peak.

Optimal control to modelling motorcycle rider steering: local versus global coordinate systems in rider preview

NASA Astrophysics Data System (ADS)

Rowell, S.; Popov, A. A.; Meijaard, J. P.

2010-04-01

The response of a motorcycle is heavily dependent on the rider's control actions, and consequently a means of replicating the rider's behaviour provides an important extension to motorcycle dynamics. The primary objective here is to develop effective path-following simulations and to understand how riders control motorcycles. Optimal control theory is applied to the tracking of roadway by a motorcycle, using a non-linear motorcycle model operating in free control by steering torque input. A path-following controller with road preview is designed by minimising tracking errors and control effort. Tight controls with high weightings on performance and loose controls with high weightings on control power are defined. Special attention is paid to the modelling of multipoint preview in local and global coordinate systems. The controller model is simulated over a standard single lane-change manoeuvre. It is argued that the local coordinates point of view is more representative of the way that a human rider operates and interprets information. The simulations suggest that for accurate path following, using optimal control, the problem must be solved by the local coordinates approach in order to achieve accurate results with short preview horizons. Furthermore, some weaknesses of the optimal control approach are highlighted here.

Fine genetic mapping of the gene for nevoid basal cell carcinoma syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wicking, C.; Berkman, J.; Wainwright, B.

1994-08-01

Nevoid basal cell carcinoma syndrome (NBCCS, or Gorlin syndrome) is a cancer predisposition syndrome characterized by multiple basal cell carcinomas and diverse developmental defects. The gene responsible for NBCCS, which is most likely to be a tumor suppressor gene, has previously been mapped to 9q22.3-q31 in a 12-cM interval between the microsatellite marker loci D9S12.1 and D9S109. Combined multipoint and haplotype analyses of additional polymorphisms in this region in our collection of Australasian pedigrees have further refined the localization of the gene to between the markers D9S196 and D9S180, an interval reported to be approximately 2 cM. 27 refs., 4more » figs., 1 tab.« less

TURBULENCE-GENERATED PROTON-SCALE STRUCTURES IN THE TERRESTRIAL MAGNETOSHEATH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vörös, Zoltán; Narita, Yasuhito; Yordanova, Emiliya

2016-03-01

Recent results of numerical magnetohydrodynamic simulations suggest that in collisionless space plasmas, turbulence can spontaneously generate thin current sheets. These coherent structures can partially explain the intermittency and the non-homogenous distribution of localized plasma heating in turbulence. In this Letter, Cluster multi-point observations are used to investigate the distribution of magnetic field discontinuities and the associated small-scale current sheets in the terrestrial magnetosheath downstream of a quasi-parallel bow shock. It is shown experimentally, for the first time, that the strongest turbulence-generated current sheets occupy the long tails of probability distribution functions associated with extremal values of magnetic field partial derivatives.more » During the analyzed one-hour time interval, about a hundred strong discontinuities, possibly proton-scale current sheets, were observed.« less

Stray light analysis for the Thomson scattering diagnostic of the ETE Tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berni, L. A.; Albuquerque, B. F. C.

2010-12-15

Thomson scattering is a well-established diagnostic for measuring local electron temperature and density in fusion plasma, but this technique is particularly difficult to implement due to stray light that can easily mask the scattered signal from plasma. To mitigate this problem in the multipoint Thomson scattering system implemented at the ETE (Experimento Tokamak Esferico) a detailed stray light analysis was performed. The diagnostic system was simulated in ZEMAX software and scattering profiles of the mechanical parts were measured in the laboratory in order to have near realistic results. From simulation, it was possible to identify the main points that contributemore » to the stray signals and changes in the dump were implemented reducing the stray light signals up to 60 times.« less

Synchronous high speed multi-point velocity profile measurement by heterodyne interferometry

NASA Astrophysics Data System (ADS)

Hou, Xueqin; Xiao, Wen; Chen, Zonghui; Qin, Xiaodong; Pan, Feng

2017-02-01

This paper presents a synchronous multipoint velocity profile measurement system, which acquires the vibration velocities as well as images of vibrating objects by combining optical heterodyne interferometry and a high-speed CMOS-DVR camera. The high-speed CMOS-DVR camera records a sequence of images of the vibrating object. Then, by extracting and processing multiple pixels at the same time, a digital demodulation technique is implemented to simultaneously acquire the vibrating velocity of the target from the recorded sequences of images. This method is validated with an experiment. A piezoelectric ceramic plate with standard vibration characteristics is used as the vibrating target, which is driven by a standard sinusoidal signal.

Injectors for Multipoint Injection

NASA Technical Reports Server (NTRS)

Prociw, Lev Alexander (Inventor); Ryon, Jason (Inventor)

2015-01-01

An injector for a multipoint combustor system includes an inner air swirler which defines an interior flow passage and a plurality of swirler inlet ports in an upstream portion thereof. The inlet ports are configured and adapted to impart swirl on flow in the interior flow passage. An outer air cap is mounted outboard of the inner swirler. A fuel passage is defined between the inner air swirler and the outer air cap, and includes a discharge outlet between downstream portions of the inner air swirler and the outer air cap for issuing fuel for combustion. The outer air cap defines an outer air circuit configured for substantially unswirled injection of compressor discharge air outboard of the interior flow passage.

A measurement technique of time-dependent dielectric breakdown in MOS capacitors

NASA Technical Reports Server (NTRS)

Li, S. P.

1974-01-01

The statistical nature of time-dependent dielectric breakdown characteristics in MOS capacitors was evidenced by testing large numbers of capacitors fabricated on single wafers. A multipoint probe and automatic electronic visual display technique are introduced that will yield statistical results which are necessary for the investigation of temperature, electric field, thermal annealing, and radiation effects in the breakdown characteristics, and an interpretation of the physical mechanisms involved. It is shown that capacitors of area greater than 0.002 sq cm may yield worst-case results, and that a multipoint probe of capacitors of smaller sizes can be used to obtain a profile of nonuniformities in the SiO2 films.

Error analysis of multipoint flux domain decomposition methods for evolutionary diffusion problems

NASA Astrophysics Data System (ADS)

Arrarás, A.; Portero, L.; Yotov, I.

2014-01-01

We study space and time discretizations for mixed formulations of parabolic problems. The spatial approximation is based on the multipoint flux mixed finite element method, which reduces to an efficient cell-centered pressure system on general grids, including triangles, quadrilaterals, tetrahedra, and hexahedra. The time integration is performed by using a domain decomposition time-splitting technique combined with multiterm fractional step diagonally implicit Runge-Kutta methods. The resulting scheme is unconditionally stable and computationally efficient, as it reduces the global system to a collection of uncoupled subdomain problems that can be solved in parallel without the need for Schwarz-type iteration. Convergence analysis for both the semidiscrete and fully discrete schemes is presented.

Multipoint vibrometry with dynamic and static holograms.

PubMed

Haist, T; Lingel, C; Osten, W; Winter, M; Giesen, M; Ritter, F; Sandfort, K; Rembe, C; Bendel, K

2013-12-01

We report on two multipoint vibrometers with user-adjustable position of the measurement spots. Both systems are using holograms for beam deflection. The measurement is based on heterodyne interferometry with a frequency difference of 5 MHz between reference and object beam. One of the systems uses programmable positioning of the spots in the object volume but is limited concerning the light efficiency. The other system is based on static holograms in combination with mechanical adjustment of the measurement spots and does not have such a general efficiency restriction. Design considerations are given and we show measurement results for both systems. In addition, we analyze the sensitivity of the systems which is a major limitation compared to single point scanning systems.

Intelligent Mobile Technologies

NASA Technical Reports Server (NTRS)

Alena, Rick; Gilbaugh, Bruce; Glass, Brian; Swanson, Keith (Technical Monitor)

2000-01-01

Testing involves commercial radio equipment approved for export and use in Canada. Testing was conducted in the Canadian High Arctic, where hilly terrain provided the worst-case testing. SFU and Canadian governmental agencies made significant technical contributions. The only technical data related to radio testing was exchanged with SFU. Test protocols are standard radio tests performed by communication technicians worldwide. The Joint Fields Operations objectives included the following: (1) to provide Internet communications services for field science work and mobile exploration systems; (2) to evaluate the range and throughput of three different medium-range radio link technologies for providing coverage of the crater area; and (3) to demonstrate collaborative software such as NetMeeting with multi-point video for exchange of scientific information between remote node and base-base camp and science centers as part of communications testing.

A newly identified calculation discrepancy of the Sunset semi-continuous carbon analyzer

NASA Astrophysics Data System (ADS)

Zheng, G.; Cheng, Y.; He, K.; Duan, F.; Ma, Y.

2014-01-01

Sunset Semi-Continuous Carbon Analyzer (SCCA) is an instrument widely used for carbonaceous aerosol measurement. Despite previous validation work, here we identified a new type of SCCA calculation discrepancy caused by the default multi-point baseline correction method. When exceeding a certain threshold carbon load, multi-point correction could cause significant Total Carbon (TC) underestimation. This calculation discrepancy was characterized for both sucrose and ambient samples with three temperature protocols. For ambient samples, 22%, 36% and 12% TC was underestimated by the three protocols, respectively, with corresponding threshold being ~0, 20 and 25 μg C. For sucrose, however, such discrepancy was observed with only one of these protocols, indicating the need of more refractory SCCA calibration substance. The discrepancy was less significant for the NIOSH (National Institute for Occupational Safety and Health)-like protocol compared with the other two protocols based on IMPROVE (Interagency Monitoring of PROtected Visual Environments). Although the calculation discrepancy could be largely reduced by the single-point baseline correction method, the instrumental blanks of single-point method were higher. Proposed correction method was to use multi-point corrected data when below the determined threshold, while use single-point results when beyond that threshold. The effectiveness of this correction method was supported by correlation with optical data.

A newly identified calculation discrepancy of the Sunset semi-continuous carbon analyzer

NASA Astrophysics Data System (ADS)

Zheng, G. J.; Cheng, Y.; He, K. B.; Duan, F. K.; Ma, Y. L.

2014-07-01

The Sunset semi-continuous carbon analyzer (SCCA) is an instrument widely used for carbonaceous aerosol measurement. Despite previous validation work, in this study we identified a new type of SCCA calculation discrepancy caused by the default multipoint baseline correction method. When exceeding a certain threshold carbon load, multipoint correction could cause significant total carbon (TC) underestimation. This calculation discrepancy was characterized for both sucrose and ambient samples, with two protocols based on IMPROVE (Interagency Monitoring of PROtected Visual Environments) (i.e., IMPshort and IMPlong) and one NIOSH (National Institute for Occupational Safety and Health)-like protocol (rtNIOSH). For ambient samples, the IMPshort, IMPlong and rtNIOSH protocol underestimated 22, 36 and 12% of TC, respectively, with the corresponding threshold being ~ 0, 20 and 25 μgC. For sucrose, however, such discrepancy was observed only with the IMPshort protocol, indicating the need of more refractory SCCA calibration substance. Although the calculation discrepancy could be largely reduced by the single-point baseline correction method, the instrumental blanks of single-point method were higher. The correction method proposed was to use multipoint-corrected data when below the determined threshold, and use single-point results when beyond that threshold. The effectiveness of this correction method was supported by correlation with optical data.

Advanced analysis of forest fire clustering

NASA Astrophysics Data System (ADS)

Kanevski, Mikhail; Pereira, Mario; Golay, Jean

2017-04-01

Analysis of point pattern clustering is an important topic in spatial statistics and for many applications: biodiversity, epidemiology, natural hazards, geomarketing, etc. There are several fundamental approaches used to quantify spatial data clustering using topological, statistical and fractal measures. In the present research, the recently introduced multi-point Morisita index (mMI) is applied to study the spatial clustering of forest fires in Portugal. The data set consists of more than 30000 fire events covering the time period from 1975 to 2013. The distribution of forest fires is very complex and highly variable in space. mMI is a multi-point extension of the classical two-point Morisita index. In essence, mMI is estimated by covering the region under study by a grid and by computing how many times more likely it is that m points selected at random will be from the same grid cell than it would be in the case of a complete random Poisson process. By changing the number of grid cells (size of the grid cells), mMI characterizes the scaling properties of spatial clustering. From mMI, the data intrinsic dimension (fractal dimension) of the point distribution can be estimated as well. In this study, the mMI of forest fires is compared with the mMI of random patterns (RPs) generated within the validity domain defined as the forest area of Portugal. It turns out that the forest fires are highly clustered inside the validity domain in comparison with the RPs. Moreover, they demonstrate different scaling properties at different spatial scales. The results obtained from the mMI analysis are also compared with those of fractal measures of clustering - box counting and sand box counting approaches. REFERENCES Golay J., Kanevski M., Vega Orozco C., Leuenberger M., 2014: The multipoint Morisita index for the analysis of spatial patterns. Physica A, 406, 191-202. Golay J., Kanevski M. 2015: A new estimator of intrinsic dimension based on the multipoint Morisita index. Pattern Recognition, 48, 4070-4081.

Estimation of the effects of multipoint pacing on battery longevity in routine clinical practice.

PubMed

Akerström, Finn; Narváez, Irene; Puchol, Alberto; Pachón, Marta; Martín-Sierra, Cristina; Rodríguez-Mañero, Moisés; Rodríguez-Padial, Luis; Arias, Miguel A

2017-09-23

Multipoint pacing (MPP) permits simultaneous multisite pacing of the left ventricle (LV); initial studies suggest haemodynamic and clinical benefits over conventional (single LV site) cardiac resynchronization therapy (CRT). The aim of this study was to estimate the impact of MPP activation on battery longevity in routine clinical practice. Patient (n = 46) and device data were collected from two centres at least 3 months after MPP-CRT device implantation. Multipoint pacing programming was based on the maximal possible anatomical LV1/LV2 separation according to three predefined LV pacing capture threshold (PCT) cut-offs (≤1.5 V; ≤4.0 V; and ≤6.5 V). Estimated battery longevity was calculated using the programmed lower rate limit, lead impedances, outputs, and pacing percentages. Relative to the longevity for conventional CRT using the lowest PCT (8.9 ± 1.2 years), MPP activation significantly shortened battery longevity for all three PCT cut-offs (≤1.5 V, -5.6%; ≤4.0 V, -16.9%; ≤6.5 V, -21.3%; P's <0.001). When compared with conventional CRT based on longest right ventricle-LV delay (8.3 ± 1.3 years), battery longevity was significantly shortened for the MPP ≤ 4.0 V and ≤6.5 V cut-offs (-10.8 and -15.7%, respectively; P's <0.001). Maximal LV1/LV2 spacing was possible in 23.9% (≤1.5 V), 56.5% (≤4.0 V), and 69.6% (≤6.5 V) of patients. Multipoint pacing activation significantly reduces battery longevity compared with that for conventional CRT configuration. When reasonable MPP LV vector PCTs (≤4.0 V) are achieved, the decrease in battery longevity is relatively small which may prompt the clinician to activate MPP. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.

An approach for aerodynamic optimization of transonic fan blades

NASA Astrophysics Data System (ADS)

Khelghatibana, Maryam

Aerodynamic design optimization of transonic fan blades is a highly challenging problem due to the complexity of flow field inside the fan, the conflicting design requirements and the high-dimensional design space. In order to address all these challenges, an aerodynamic design optimization method is developed in this study. This method automates the design process by integrating a geometrical parameterization method, a CFD solver and numerical optimization methods that can be applied to both single and multi-point optimization design problems. A multi-level blade parameterization is employed to modify the blade geometry. Numerical analyses are performed by solving 3D RANS equations combined with SST turbulence model. Genetic algorithms and hybrid optimization methods are applied to solve the optimization problem. In order to verify the effectiveness and feasibility of the optimization method, a singlepoint optimization problem aiming to maximize design efficiency is formulated and applied to redesign a test case. However, transonic fan blade design is inherently a multi-faceted problem that deals with several objectives such as efficiency, stall margin, and choke margin. The proposed multi-point optimization method in the current study is formulated as a bi-objective problem to maximize design and near-stall efficiencies while maintaining the required design pressure ratio. Enhancing these objectives significantly deteriorate the choke margin, specifically at high rotational speeds. Therefore, another constraint is embedded in the optimization problem in order to prevent the reduction of choke margin at high speeds. Since capturing stall inception is numerically very expensive, stall margin has not been considered as an objective in the problem statement. However, improving near-stall efficiency results in a better performance at stall condition, which could enhance the stall margin. An investigation is therefore performed on the Pareto-optimal solutions to demonstrate the relation between near-stall efficiency and stall margin. The proposed method is applied to redesign NASA rotor 67 for single and multiple operating conditions. The single-point design optimization showed +0.28 points improvement of isentropic efficiency at design point, while the design pressure ratio and mass flow are, respectively, within 0.12% and 0.11% of the reference blade. Two cases of multi-point optimization are performed: First, the proposed multi-point optimization problem is relaxed by removing the choke margin constraint in order to demonstrate the relation between near-stall efficiency and stall margin. An investigation on the Pareto-optimal solutions of this optimization shows that the stall margin has been increased with improving near-stall efficiency. The second multi-point optimization case is performed with considering all the objectives and constraints. One selected optimized design on the Pareto front presents +0.41, +0.56 and +0.9 points improvement in near-peak efficiency, near-stall efficiency and stall margin, respectively. The design pressure ratio and mass flow are, respectively, within 0.3% and 0.26% of the reference blade. Moreover the optimized design maintains the required choking margin. Detailed aerodynamic analyses are performed to investigate the effect of shape optimization on shock occurrence, secondary flows, tip leakage and shock/tip-leakage interactions in both single and multi-point optimizations.

Multi-point laser ignition device

DOEpatents

McIntyre, Dustin L.; Woodruff, Steven D.

2017-01-17

A multi-point laser device comprising a plurality of optical pumping sources. Each optical pumping source is configured to create pumping excitation energy along a corresponding optical path directed through a high-reflectivity mirror and into substantially different locations within the laser media thereby producing atomic optical emissions at substantially different locations within the laser media and directed along a corresponding optical path of the optical pumping source. An output coupler and one or more output lenses are configured to produce a plurality of lasing events at substantially different times, locations or a combination thereof from the multiple atomic optical emissions produced at substantially different locations within the laser media. The laser media is a single continuous media, preferably grown on a single substrate.

Multipoint vibrometry with dynamic and static holograms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haist, T.; Lingel, C.; Osten, W.

2013-12-15

We report on two multipoint vibrometers with user-adjustable position of the measurement spots. Both systems are using holograms for beam deflection. The measurement is based on heterodyne interferometry with a frequency difference of 5 MHz between reference and object beam. One of the systems uses programmable positioning of the spots in the object volume but is limited concerning the light efficiency. The other system is based on static holograms in combination with mechanical adjustment of the measurement spots and does not have such a general efficiency restriction. Design considerations are given and we show measurement results for both systems. Inmore » addition, we analyze the sensitivity of the systems which is a major limitation compared to single point scanning systems.« less

Development of a Novel Two Dimensional Surface Plasmon Resonance Sensor Using Multiplied Beam Splitting Optics

PubMed Central

Hemmi, Akihide; Mizumura, Ryosuke; Kawanishi, Ryuta; Nakajima, Hizuru; Zeng, Hulie; Uchiyama, Katsumi; Kaneki, Noriaki; Imato, Toshihiko

2013-01-01

A novel two dimensional surface plasmon resonance (SPR) sensor system with a multi-point sensing region is described. The use of multiplied beam splitting optics, as a core technology, permitted multi-point sensing to be achieved. This system was capable of simultaneously measuring nine sensing points. Calibration curves for sucrose obtained on nine sensing points were linear in the range of 0–10% with a correlation factor of 0.996–0.998 with a relative standard deviation of 0.090–4.0%. The detection limits defined as S/N = 3 were 1.98 × 10−6–3.91 × 10−5 RIU. This sensitivity is comparable to that of conventional SPR sensors. PMID:23299626

Uncertainty evaluation in normalization of isotope delta measurement results against international reference materials.

PubMed

Meija, Juris; Chartrand, Michelle M G

2018-01-01

Isotope delta measurements are normalized against international reference standards. Although multi-point normalization is becoming a standard practice, the existing uncertainty evaluation practices are either undocumented or are incomplete. For multi-point normalization, we present errors-in-variables regression models for explicit accounting of the measurement uncertainty of the international standards along with the uncertainty that is attributed to their assigned values. This manuscript presents framework to account for the uncertainty that arises due to a small number of replicate measurements and discusses multi-laboratory data reduction while accounting for inevitable correlations between the laboratories due to the use of identical reference materials for calibration. Both frequentist and Bayesian methods of uncertainty analysis are discussed.

Deployment Design of Wireless Sensor Network for Simple Multi-Point Surveillance of a Moving Target

PubMed Central

Tsukamoto, Kazuya; Ueda, Hirofumi; Tamura, Hitomi; Kawahara, Kenji; Oie, Yuji

2009-01-01

In this paper, we focus on the problem of tracking a moving target in a wireless sensor network (WSN), in which the capability of each sensor is relatively limited, to construct large-scale WSNs at a reasonable cost. We first propose two simple multi-point surveillance schemes for a moving target in a WSN and demonstrate that one of the schemes can achieve high tracking probability with low power consumption. In addition, we examine the relationship between tracking probability and sensor density through simulations, and then derive an approximate expression representing the relationship. As the results, we present guidelines for sensor density, tracking probability, and the number of monitoring sensors that satisfy a variety of application demands. PMID:22412326

Solar and Space Physics Science Enabled by Pico and Nano Satellites

NASA Astrophysics Data System (ADS)

Swenson, C.; Fish, C. S.

2012-12-01

The most significant advances in solar and space physics, or Heliophysics, over the next decade are most likely to derive from new observational techniques. The connection between advances in scientific understanding and technology has historically been demonstrated across many disciplines and time. Progress on some of the most compelling scientific problems will most likely occur through multipoint observations within the space environment to understand the coupling between disparate regions: Heliosphere, magnetosphere, ionosphere, thermosphere and mesosphere. Multipoint measurements are also needed to develop understanding of the various scalars or vector field signatures (i.e gradients, divergence) that arise from coupling processes that occur across temporal and spatial scales or within localized regions. The resources that are available over the next decades for all areas of Heliophysics research have limits and it is therefore important that the community be innovative in developing new observational techniques to advance science. One of the most promising new observational techniques becoming available are miniaturized sensors and satellite systems called pico- or nano-satellites and CubeSats. These are enabled by the enormous investment of the commercial, medical, and defense industries in producing highly capable, portable and low-power battery-operated consumer electronics, in-situ composition probes, and novel reconnaissance sensors. The advancements represented by these technologies have direct application in developing pico- or nano-satellites and CubeSats system for Heliophysics research. In this talk we overview the current environment and technologies surrounding these novel small satellites and discuss the types and capabilities of the miniature sensors that are being developed. We discuss how pico- or nano-satellites and CubeSats can be used to address highest priority science identified in the Decadal Survey and the innovations and advancements that are required to make substantial progress.

Chorus Whistler Wave Source Scales As Determined From Multipoint Van Allen Probe Measurements

NASA Technical Reports Server (NTRS)

Agapitov, O.; Blum, L. W.; Mozer, F. S.; Bonnell, J. W.; Wygant, J.

2017-01-01

Whistler mode chorus waves are particularly important in outer radiation belt dynamics due to their key role in controlling the acceleration and scattering of electrons over a very wide energy range. The key parameters for both nonlinear and quasi-linear treatment of wave-particle interactions are the temporal and spatial scales of the wave source region and coherence of the wave field perturbations. Neither the source scale nor the coherence scale is well established experimentally, mostly because of a lack of multipoint VLF waveform measurements. We present an unprecedentedly long interval of coordinated VLF waveform measurements (sampled at 16384 s(exp -1)) aboard the two Van Allen Probes spacecraft-9 h (0800-1200 UT and 1700-2200 UT) during two consecutive apogees on 15 July 2014. The spacecraft separations varied from about 100 to 5000 km (mostly radially); measurements covered an L shell range from 3 to 6; magnetic local time 0430-0900, and magnetic latitudes were approximately 15 and approximately 5 deg during the two orbits. Using time-domain correlation techniques, the single chorus source spatial extent transverse to the background magnetic field has been determined to be about 550-650 km for upper band chorus waves with amplitudes less than 100 pT and up to 800 km for larger amplitude, lower band chorus waves. The ratio between wave amplitudes measured on the two spacecraft is also examined to reveal that the wave amplitude distribution within a single chorus element generation area can be well approximated by a Gaussian exp(-0.5 x r (exp 2)/r(sub 0)(exp 2)), with the characteristic scale r(sub 0) around 300 km. Waves detected by the two spacecraft were found to be coherent in phase at distances up to 400 km.

Multi-point Shock and Flux Rope Analysis of Multiple Interplanetary Coronal Mass Ejections around 2010 August 1 in the Inner Heliosphere

NASA Astrophysics Data System (ADS)

Möstl, C.; Farrugia, C. J.; Kilpua, E. K. J.; Jian, L. K.; Liu, Y.; Eastwood, J. P.; Harrison, R. A.; Webb, D. F.; Temmer, M.; Odstrcil, D.; Davies, J. A.; Rollett, T.; Luhmann, J. G.; Nitta, N.; Mulligan, T.; Jensen, E. A.; Forsyth, R.; Lavraud, B.; de Koning, C. A.; Veronig, A. M.; Galvin, A. B.; Zhang, T. L.; Anderson, B. J.

2012-10-01

We present multi-point in situ observations of a complex sequence of coronal mass ejections (CMEs) which may serve as a benchmark event for numerical and empirical space weather prediction models. On 2010 August 1, instruments on various space missions, Solar Dynamics Observatory/Solar and Heliospheric Observatory/Solar-TErrestrial-RElations-Observatory (SDO/SOHO/STEREO), monitored several CMEs originating within tens of degrees from the solar disk center. We compare their imprints on four widely separated locations, spanning 120° in heliospheric longitude, with radial distances from the Sun ranging from MESSENGER (0.38 AU) to Venus Express (VEX, at 0.72 AU) to Wind, ACE, and ARTEMIS near Earth and STEREO-B close to 1 AU. Calculating shock and flux rope parameters at each location points to a non-spherical shape of the shock, and shows the global configuration of the interplanetary coronal mass ejections (ICMEs), which have interacted, but do not seem to have merged. VEX and STEREO-B observed similar magnetic flux ropes (MFRs), in contrast to structures at Wind. The geomagnetic storm was intense, reaching two minima in the Dst index (≈ - 100 nT), and was caused by the sheath region behind the shock and one of two observed MFRs. MESSENGER received a glancing blow of the ICMEs, and the events missed STEREO-A entirely. The observations demonstrate how sympathetic solar eruptions may immerse at least 1/3 of the heliosphere in the ecliptic with their distinct plasma and magnetic field signatures. We also emphasize the difficulties in linking the local views derived from single-spacecraft observations to a consistent global picture, pointing to possible alterations from the classical picture of ICMEs.

Further localization of the gene for nevoid basal cell carcinoma syndrome (NBCCS) in 15 Australasian families: Linkage and loss of heterozygosity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chenevix-Trench, G.; Wicking, C.; Berkman, J.

Nevoid basal cell carcinoma syndrome (NBCCS; basal cell nevus syndrome or Gorlin syndrome) is a cancer-predisposition syndrome characterized by multiple basal cell carcinomas (BCCs) and diverse developmental defects. The gene for NBCCS has been mapped to 9q23.1-q31 in North Americal and European families. In addition, loss of heterozygosity (LOH) for genetic markers in this region has been detected in sporadic BCCs, indicating that the NBCCs gene is probably a tumor-suppressor gene. In this study the authors have determined that the NBCCS gene is also linked to this region in Australasian pedigrees and that there is no significant evidence of heterogeneity.more » They have defined the localization of the gene by multipoint and haplotype analysis of 15 families, using four microsatellite markers. LOH at these loci was detected in 50% of sporadic BCCs, a rate that is significantly higher than that in other skin lesions used as controls. 21 refs., 3 figs., 2 tabs.« less

A strabismus susceptibility locus on chromosome 7p

PubMed Central

Parikh, Vaishali; Shugart, Yin Yao; Doheny, Kimberly F.; Zhang, Jie; Li, Lan; Williams, John; Hayden, David; Craig, Brian; Capo, Hilda; Chamblee, Denise; Chen, Cathy; Collins, Mary; Dankner, Stuart; Fiergang, Dean; Guyton, David; Hunter, David; Hutcheon, Marcia; Keys, Marshall; Morrison, Nancy; Munoz, Michelle; Parks, Marshall; Plotsky, David; Protzko, Eugene; Repka, Michael X.; Sarubbi, Maria; Schnall, Bruce; Siatkowski, R. Michael; Traboulsi, Elias; Waeltermann, Joanne; Nathans, Jeremy

2003-01-01

Strabismus has been known to have a significant genetic component, but the mode of inheritance and the identity of the relevant genes have been enigmatic. This paper reports linkage analysis of nonsyndromic strabismus. The principal results of this study are: (i) the demonstrated feasibility of identifying and recruiting large families in which multiple members have (or had) strabismus; (ii) the linkage in one large family of a presumptive strabismus susceptibility locus to 7p22.1 with a multipoint logarithm of odds score of 4.51 under a model of recessive inheritance; and (iii) the failure to observe significant linkage to 7p in six other multiplex families, consistent with genetic heterogeneity among families. These findings suggest that it will be possible to localize and ultimately identify strabismus susceptibility genes by linkage analysis and mutation screening of candidate genes. PMID:14519848

Conceptual design of a divertor Thomson scattering diagnostic for NSTX-U

DOE Office of Scientific and Technical Information (OSTI.GOV)

McLean, A. G., E-mail: mclean@fusion.gat.com; Soukhanovskii, V. A.; Allen, S. L.

2014-11-15

A conceptual design for a divertor Thomson scattering (DTS) diagnostic has been developed for the NSTX-U device to operate in parallel with the existing multipoint Thomson scattering system. Higher projected peak heat flux in NSTX-U will necessitate application of advanced magnetics geometries and divertor detachment. Interpretation and modeling of these divertor scenarios will depend heavily on local measurement of electron temperature, T{sub e}, and density, n{sub e}, which DTS provides in a passive manner. The DTS design for NSTX-U adopts major elements from the successful DIII-D DTS system including 7-channel polychromators measuring T{sub e} to 0.5 eV. If implemented onmore » NSTX-U, the divertor TS system would provide an invaluable diagnostic for the boundary program to characterize the edge plasma.« less

Implementing a distributed intranet-based information system.

PubMed

O'Kane, K C; McColligan, E E; Davis, G A

1996-11-01

The article discusses Internet and intranet technologies and describes how to install an intranet-based information system using the Merle language facility and other readily available components. Merle is a script language designed to support decentralized medical record information retrieval applications on the World Wide Web. The goal of this work is to provide a script language tool to facilitate construction of efficient, fully functional, multipoint medical record information systems that can be accessed anywhere by low-cost Web browsers to search, retrieve, and analyze patient information. The language allows legacy MUMPS applications to function in a Web environment and to make use of the Web graphical, sound, and video presentation services. It also permits downloading of script applets for execution on client browsers, and it can be used in standalone mode with the Unix, Windows 95, Windows NT, and OS/2 operating systems.

Fibre Optic Sensors for Structural Health Monitoring of Aircraft Composite Structures: Recent Advances and Applications

PubMed Central

Di Sante, Raffaella

2015-01-01

In-service structural health monitoring of composite aircraft structures plays a key role in the assessment of their performance and integrity. In recent years, Fibre Optic Sensors (FOS) have proved to be a potentially excellent technique for real-time in-situ monitoring of these structures due to their numerous advantages, such as immunity to electromagnetic interference, small size, light weight, durability, and high bandwidth, which allows a great number of sensors to operate in the same system, and the possibility to be integrated within the material. However, more effort is still needed to bring the technology to a fully mature readiness level. In this paper, recent research and applications in structural health monitoring of composite aircraft structures using FOS have been critically reviewed, considering both the multi-point and distributed sensing techniques. PMID:26263987

Fibre Optic Sensors for Structural Health Monitoring of Aircraft Composite Structures: Recent Advances and Applications.

PubMed

Di Sante, Raffaella

2015-07-30

In-service structural health monitoring of composite aircraft structures plays a key role in the assessment of their performance and integrity. In recent years, Fibre Optic Sensors (FOS) have proved to be a potentially excellent technique for real-time in-situ monitoring of these structures due to their numerous advantages, such as immunity to electromagnetic interference, small size, light weight, durability, and high bandwidth, which allows a great number of sensors to operate in the same system, and the possibility to be integrated within the material. However, more effort is still needed to bring the technology to a fully mature readiness level. In this paper, recent research and applications in structural health monitoring of composite aircraft structures using FOS have been critically reviewed, considering both the multi-point and distributed sensing techniques.

A multiobjective hybrid genetic algorithm for the capacitated multipoint network design problem.

PubMed

Lo, C C; Chang, W H

2000-01-01

The capacitated multipoint network design problem (CMNDP) is NP-complete. In this paper, a hybrid genetic algorithm for CMNDP is proposed. The multiobjective hybrid genetic algorithm (MOHGA) differs from other genetic algorithms (GAs) mainly in its selection procedure. The concept of subpopulation is used in MOHGA. Four subpopulations are generated according to the elitism reservation strategy, the shifting Prufer vector, the stochastic universal sampling, and the complete random method, respectively. Mixing these four subpopulations produces the next generation population. The MOHGA can effectively search the feasible solution space due to population diversity. The MOHGA has been applied to CMNDP. By examining computational and analytical results, we notice that the MOHGA can find most nondominated solutions and is much more effective and efficient than other multiobjective GAs.

AVST Morphing Project Research Summaries in Fiscal Year 2001

NASA Technical Reports Server (NTRS)

McGowan, Anna-Maria R.

2002-01-01

The Morphing project at the National Aeronautics and Space Agency's Langley Research Center is part of the Aerospace Vehicle Systems Program Office that conducts fundamental research on advanced technologies for future flight vehicles. The objectives of the Morphing project are to develop and assess advanced technologies and integrated component concepts to enable efficient, multi-point adaptability in air and space vehicles. In the context of the project, the word "morphing" is defined as "efficient, multi-point adaptability" and may include micro or macro, structural or fluidic approaches. The current document on the Morphing project is a compilation of research summaries and other information on the project from fiscal year 2001. The focus of this document is to provide a brief overview of the project content, technical results and lessons learned from fiscal year 2001.

Immobilization and stabilization of pectinase by multipoint attachment onto an activated agar-gel support.

PubMed

Li, Tuoping; Li, Suhong; Wang, Na; Tain, Lirui

2008-08-15

Pectinase was immobilized on an activated agar-gel support by multipoint attachment. The maximal activity of immobilized pectinase was obtained at 5°C, pH 3.6, with a 24h reaction time at an enzyme dose of 0.52mg protein/g gel, and the gel was activated with 1.0M glycidol. These conditions increased the thermal stability of the immobilized pectinase 19-fold compared with the free enzyme at 65°C. The optimal temperature for pectinase activity changed from 40 to 50°C after immobilization; however, the optimal pH remained unchanged. The immobilized enzyme also exhibited great operational stability, and an 81% residual activity was observed in the immobilized enzyme after 10 batch reactions. Copyright © 2008 Elsevier Ltd. All rights reserved.

A proposal for an SDN-based SIEPON architecture

NASA Astrophysics Data System (ADS)

Khalili, Hamzeh; Sallent, Sebastià; Piney, José Ramón; Rincón, David

2017-11-01

Passive Optical Network (PON) elements such as Optical Line Terminal (OLT) and Optical Network Units (ONUs) are currently managed by inflexible legacy network management systems. Software-Defined Networking (SDN) is a new networking paradigm that improves the operation and management of networks. In this paper, we propose a novel architecture, based on the SDN concept, for Ethernet Passive Optical Networks (EPON) that includes the Service Interoperability standard (SIEPON). In our proposal, the OLT is partially virtualized and some of its functionalities are allocated to the core network management system, while the OLT itself is replaced by an OpenFlow (OF) switch. A new MultiPoint MAC Control (MPMC) sublayer extension based on the OpenFlow protocol is presented. This would allow the SDN controller to manage and enhance the resource utilization, flow monitoring, bandwidth assignment, quality-of-service (QoS) guarantees, and energy management of the optical network access, to name a few possibilities. The OpenFlow switch is extended with synchronous ports to retain the time-critical nature of the EPON network. OpenFlow messages are also extended with new functionalities to implement the concept of EPON Service Paths (ESPs). Our simulation-based results demonstrate the effectiveness of the new architecture, while retaining a similar (or improved) performance in terms of delay and throughput when compared to legacy PONs.

Capability 9.2 Mobility

NASA Technical Reports Server (NTRS)

Zakrasjek, June

2005-01-01

Modern operational concepts require significant bandwidths and multipoint communication capabilities. Provide voice, video and data communications among vehicles moving along the surface, vehicles in suborbital transport or reconnaissance, surface elements, and home planet facilities.

Multipoint NIR spectroscopy for gross composition analysis of powdered infant formula under various motion conditions.

PubMed

Cama-Moncunill, Raquel; Markiewicz-Keszycka, Maria; Dixit, Yash; Cama-Moncunill, Xavier; Casado-Gavalda, Maria P; Cullen, Patrick J; Sullivan, Carl

2016-07-01

Powdered infant formula (PIF) is a worldwide, industrially produced, human milk substitute. Manufacture of PIF faces strict quality controls in order to ensure that the product meets all compositional requirements. Near-infrared (NIR) spectroscopy is a rapid, non-destructive and well-qualified technique for food quality assessments. The use of fibre-optic NIR sensors allows measuring in-line and at real-time, and can record spectra from different stages of the process. The non-contact character of fibre-optic sensors can be enhanced by fitting collimators, which allow operation at various distances. The system, based on a Fabry-Perot interferometer, records four spectra concurrently, rather than consecutively as in the "quasi-simultaneous" multipoint NIR systems. In the present study, a novel multipoint NIR spectroscopy system equipped with four fibre-optic probes with collimators was assessed to determine carbohydrate and protein contents of PIF samples under static and motion conditions (0.02, 0.15 and 0.30m/s) to simulate possible industrial scenarios. Best results were obtained under static conditions providing a R(2) of calibration of 0.95 and RMSEP values of 1.89%. Yet, considerably low values of RMSEP, for instance 2.70% at 0.15m/s, were provided with the in-motion predictions, demonstrating the system's potential for in/on-line applications at various levels of speed. The current work also evaluated the viability of using general off-line calibrations developed under static conditions for on/in-line applications subject to motion. To this end, calibrations in both modes were developed and compared. Best results were obtained with specific calibrations; however, reasonably accurate models were obtained with the general calibration. Furthermore, this work illustrated independency of the collimator-probe setup by characterizing PIF samples simultaneously recorded according to their carbohydrate content, even when measured under different conditions. Therefore, the improved multipoint NIR approach constitutes a potential in/on-line tool for quality evaluation of PIF over the manufacturing process. Copyright © 2016 Elsevier B.V. All rights reserved.

Global, Energy-Dependent Ring Current Response During Two Large Storms

NASA Astrophysics Data System (ADS)

Goldstein, J.; Angelopoulos, V.; Burch, J. L.; De Pascuale, S.; Fuselier, S. A.; Genestreti, K. J.; Kurth, W. S.; LLera, K.; McComas, D. J.; Reeves, G. D.; Spence, H. E.; Valek, P. W.

2015-12-01

Two recent large (~200 nT) geomagnetic storms occurred during 17--18 March 2015 and 22--23 June 2015. The global, energy-dependent ring current response to these two extreme events is investigated using both global imaging and multi-point in situ observations. Energetic neutral atom (ENA) imaging by the Two Wide-angle Imaging Neutral-atom Spectrometers (TWINS) mission provides a global view of ring current ions. Local measurements are provided by two multi-spacecraft missions. The two Van Allen Probes measure in situ plasma (including ion composition) and fields at ring current and plasmaspheric L values. The recently launched Magnetospheric Multiscale (MMS) comprises four spacecraft that have just begun to measure particles (including ion composition) and fields at outer magnetospheric L-values. We analyze the timing and energetics of the stormtime evolution of ring current ions, both trapped and precipitating, using TWINS ENA images and in situ data by the Van Allen Probes and MMS.

Multi-Point Thomson Scattering Diagnostic for the Helicity Injected Torus

NASA Astrophysics Data System (ADS)

Liptac, J. E.; Smith, R. J.; Hoffman, C. S.; Jarboe, T. R.; Nelson, B. A.; Leblanc, B. P.; Phillips, P.

1999-11-01

The multi-point Thomson scattering system on the Helicity Injected Torus--II can determine electron temperature and density at 11 radial positions at a single time during the plasma discharge. The system includes components on loan from both PPPL and from the University of Texas. The collection optics and Littrow spectrometer from Princeton, and the 1 GW laser and multi-anode microchannel plate detector from Texas have been integrated into a compact structure, creating a mobile and reliable diagnostic. The mobility of the system allows alignment to occur in a room adjacent to the experiment, greatly reducing the disturbance to normal machine operation. The four main parts of the Thomson scattering system, namely, the laser, the beam line, the collection optics, and the mobile structure are presented and discussed.

Integrated photonics for fiber optic based temperature sensing

NASA Astrophysics Data System (ADS)

Evenblij, R. S.; van Leest, T.; Haverdings, M. B.

2017-09-01

One of the promising space applications areas for fibre sensing is high reliable thermal mapping of metrology structures for effects as thermal deformation, focal plane distortion, etc. Subsequently, multi-point temperature sensing capability for payload panels and instrumentation instead of, or in addition to conventional thermo-couple technology will drastically reduce electrical wiring and sensor materials to minimize weight and costs. Current fiber sensing technologies based on solid state ASPIC (Application Specific Photonic Integrated Circuits) technology, allow significant miniaturization of instrumentation and improved reliability. These imperative aspects make the technology candidate for applications in harsh environments such as space. One of the major aspects in order to mature ASPIC technology for space is assessment on radiation hardness. This paper describes the results of radiation hardness experiments on ASPIC including typical multipoint temperature sensing and thermal mapping capabilities.

Research on the Wire Network Signal Prediction Based on the Improved NNARX Model

NASA Astrophysics Data System (ADS)

Zhang, Zipeng; Fan, Tao; Wang, Shuqing

It is difficult to obtain accurately the wire net signal of power system's high voltage power transmission lines in the process of monitoring and repairing. In order to solve this problem, the signal measured in remote substation or laboratory is employed to make multipoint prediction to gain the needed data. But, the obtained power grid frequency signal is delay. In order to solve the problem, an improved NNARX network which can predict frequency signal based on multi-point data collected by remote substation PMU is describes in this paper. As the error curved surface of the NNARX network is more complicated, this paper uses L-M algorithm to train the network. The result of the simulation shows that the NNARX network has preferable predication performance which provides accurate real time data for field testing and maintenance.

Approaching Solar Maximum 24 with Stereo-Multipoint Observations of Solar Energetic Particle Events

NASA Technical Reports Server (NTRS)

Dresing, N.; Cohen, C. M. S.; Gomez-Herrero, R.; Heber, B.; Klassen, A.; Leske, R. A.; Mason, G. M.; Mewaldt, R. A.; von Rosenvinge, T. T.

2014-01-01

Since the beginning of the Solar Terrestrial Relations Observatory (STEREO) mission at the end of 2006, the two spacecraft have now separated by more than 130? degrees from the Earth. A 360-degree view of the Sun has been possible since February 2011, providing multipoint in situ and remote sensing observations of unprecedented quality. Combining STEREO observations with near-Earth measurements allows the study of solar energetic particle (SEP) events over a wide longitudinal range with minimal radial gradient effects. This contribution provides an overview of recent results obtained by the STEREO/IMPACT team in combination with observations by the ACE and SOHO spacecraft. We focus especially on multi-spacecraft investigations of SEP events. The large longitudinal spread of electron and 3He-rich events as well as unusual anisotropies will be presented and discussed.

Searching susceptibility loci for bipolar disorder: a sib pair study on chromosome 12.

PubMed

Lorenzi, Cristina; Delmonte, Dario; Pirovano, Adele; Marino, Elena; Bongiorno, Fanny; Catalano, Marco; Colombo, Cristina; Bramanti, Placido; Smeraldi, Enrico

2010-01-01

Several linkage studies demonstrated that different chromosomal regions are involved in the susceptibility to bipolar disorder. In particular, some genome scans evidenced the role of chromosome 12. For this reason, our group chose this chromosome for a preliminary genome scan on a sample of 137 Italian sib pairs, including at least 1 bipolar subject. The analyses were carried out by means of DNA extracted from whole blood. DNA samples were genotyped by 19 simple tandem repeat markers (microsatellites). Starting from the genetic data, we performed two- and multipoint linkage analyses (both parametric and nonparametric) by means of Easy Linkage plus package (version 5.05). The multipoint linkage analyses pointed out a region suggestive of linkage between the markers D12S310 and D12S364, at locus 12p12. In particular, we reached the best evidence of linkage performing multipoint analyses and assuming a recessive model, under the hypothesis of genetic heterogeneity (heterogeneity LOD score = 2.01 and alpha = 0.77). It is interesting to notice that the region at the marker D12S364 is located inside the gene coding for the glutamatergic receptor GRIN2B. Therefore, our finding not only confirmed the role of genetics in determining liability to bipolar disorder, but suggested glutamatergic transmission impairment as a possible cause. Nevertheless, we acknowledge that our study is heavily underpowered. Therefore, independent replication is needed. (c) 2009 S. Karger AG, Basel.

Sequential multipoint motion of the tympanic membrane measured by laser Doppler vibrometry: preliminary results for normal tympanic membrane.

PubMed

Kunimoto, Yasuomi; Hasegawa, Kensaku; Arii, Shiro; Kataoka, Hideyuki; Yazama, Hiroaki; Kuya, Junko; Kitano, Hiroya

2014-04-01

Numerous studies have reported sound-induced motion of the tympanic membrane (TM). To demonstrate sequential motion characteristics of the entire TM by noncontact laser Doppler vibrometry (LDV), we have investigated multipoint TM measurement. A laser Doppler vibrometer was mounted on a surgical microscope. The velocity was measured at 33 points on the TM using noncontact LDV without any reflectors. Measurements were performed with tonal stimuli of 1, 3, and 6 kHz. Amplitudes were calculated from these measurements, and time-dependent changes in TM motion were described using a graphics application. TM motions were detected more clearly and stably at 1 and 3 kHz than at other frequencies. This is because the external auditory canal acted as a resonant tube near 3 kHz. TM motion displayed 1 peak at 1 kHz and 2 peaks at 3 kHz. Large amplitudes were detected in the posterosuperior quadrant (PSQ) at 1 kHz and in the PSQ and anteroinferior quadrant (AIQ) at 3 kHz. The entire TM showed synchronized movement centered on the PSQ at 1 kHz, with phase-shifting between PSQ and AIQ movement at 3 kHz. Amplitude was smaller at the umbo than at other parts. In contrast, amplitudes at high frequencies were too small and complicated to detect any obvious peaks. Sequential multipoint motion of the tympanic membrane showed that vibration characteristics of the TM differ according to the part and frequency.

Celestial data routing network

NASA Astrophysics Data System (ADS)

Bordetsky, Alex

2000-11-01

Imagine that information processing human-machine network is threatened in a particular part of the world. Suppose that an anticipated threat of physical attacks could lead to disruption of telecommunications network management infrastructure and access capabilities for small geographically distributed groups engaged in collaborative operations. Suppose that small group of astronauts are exploring the solar planet and need to quickly configure orbital information network to support their collaborative work and local communications. The critical need in both scenarios would be a set of low-cost means of small team celestial networking. To the geographically distributed mobile collaborating groups such means would allow to maintain collaborative multipoint work, set up orbital local area network, and provide orbital intranet communications. This would be accomplished by dynamically assembling the network enabling infrastructure of the small satellite based router, satellite based Codec, and set of satellite based intelligent management agents. Cooperating single function pico satellites, acting as agents and personal switching devices together would represent self-organizing intelligent orbital network of cooperating mobile management nodes. Cooperative behavior of the pico satellite based agents would be achieved by comprising a small orbital artificial neural network capable of learning and restructing the networking resources in response to the anticipated threat.

Localization of Usher syndrome type II to chromosome 1q.

PubMed

Kimberling, W J; Weston, M D; Möller, C; Davenport, S L; Shugart, Y Y; Priluck, I A; Martini, A; Milani, M; Smith, R J

1990-06-01

Usher syndrome is characterized by congenital hearing loss, progressive visual impairment due to retinitis pigmentosa, and variable vestibular problems. The two subtypes of Usher syndrome, types I and II, can be distinguished by the degree of hearing loss and by the presence or absence of vestibular dysfunction. Type I is characterized by a profound hearing loss and totally absent vestibular responses, while type II has a milder hearing loss and normal vestibular function. Fifty-five members of eight type II Usher syndrome families were typed for three DNA markers in the distal region of chromosome 1q: D1S65 (pEKH7.4), REN (pHRnES1.9), and D1S81 (pTHH33). Statistically significant linkage was observed for Usher syndrome type II with a maximum multipoint lod score of 6.37 at the position of the marker THH33, thus localizing the Usher type II (USH2) gene to 1q. Nine families with type I Usher syndrome failed to show linkage to the same three markers. The statistical test for heterogeneity of linkage between Usher syndrome types I and II was highly significant, thus demonstrating that they are due to mutations at different genetic loci.

Synchronization of Multipoint Hoists

DTIC Science & Technology

A contractor has conceived an electrohydraulic feedback system that will provide position synchronization of four aircraft cargo hoists. To... synchronized hoist system. Test results show that the feedback system concept provides adequate synchronization control; i.e., the platform pitch and roll

Comparison of modal test results - Multipoint sine versus single-point random. [for Mariner Jupiter/Saturn spacecraft

NASA Technical Reports Server (NTRS)

Leppert, E. L.; Lee, S. H.; Day, F. D.; Chapman, P. C.; Wada, B. K.

1976-01-01

The Mariner Jupiter/Saturn (MJS) spacecraft was subjected to the traditional multipoint sine dwell (MPSD) modal test using 111 accelerometer channels, and also to single-point random (SPR) testing using 26 accelerometer channels, and the two methods are compared according to cost, schedule, and technical criteria. A measure of comparison between the systems was devised in terms of the cumulative difference in the kinetic energy distribution of the common accelerometers. The SPR and MPSD method show acceptable agreement with respect to frequencies and mode damping. The merit of the SPR method is that the excitation points are minimized and the test article can be committed to other uses while data analysis is performed. The MPSD approach allows validity of the data to be determined as the test progresses. Costs are about the same for the two methods.

Optical Measurements in a Combustor Using a 9-Point Swirl-Venturi Fuel Injector

NASA Technical Reports Server (NTRS)

Hicks, Yolanda R.; Anderson, Robert C.; Locke, Randy J.

2007-01-01

This paper highlights the use of two-dimensional data to characterize a multipoint swirl-venturi injector. The injector is based on a NASA-conceived lean direct injection concept. Using a variety of advanced optical diagnostic techniques, we examine the flows resultant from multipoint, lean-direct injectors that have nine injection sites arranged in a 3 x 3 grid. The measurements are made within an optically-accessible, jet-A-fueled, 76-mm by 76-mm flame tube combustor. Combustion species mapping and velocity measurements are obtained using planar laser-induced fluorescence of OH and fuel, planar laser scatter of liquid fuel, chemiluminescence from CH*, NO*, and OH*, and particle image velocimetry of seeded air (non-fueled). These measurements are used to study fuel injection, mixedness, and combustion processes and are part of a database of measurements that will be used for validating computational combustion models.

Fabrication of Multi-point Side-Firing Optical Fiber by Laser Micro-ablation

PubMed Central

Nguyen, Hoang; Arnob, Md Masud Parvez; Becker, Aaron T; Wolfe, John C; Hogan, Matthew K; Horner, Philip J; Shih, Wei-Chuan

2018-01-01

A multi-point, side-firing design enables an optical fiber to output light at multiple desired locations along the fiber body. This provides advantages over traditional end-to-end fibers, especially in applications requiring fiber bundles such as brain stimulation or remote sensing. This paper demonstrates that continuous wave (CW) laser micro-ablation can controllably create conical-shaped cavities, or side windows, for outputting light. The dimensions of these cavities determine the amount of firing light and their firing angle. Experimental data show that a single side window on a 730 μm fiber can deliver more than 8 % of the input light. This was increased to more than 19 % on a 65 μm fiber with side windows created using femtosecond (fs) laser ablation and chemical etching. Fine control of light distribution along an optical fiber is critical for various biomedical applications such as light activated drug-release and optogenetics studies. PMID:28454166

A DNA Tracer System for Hydrological Environment Investigations.

PubMed

Liao, Renkuan; Yang, Peiling; Wu, Wenyong; Luo, Dan; Yang, Dayong

2018-02-20

To monitor and manage hydrological pollution effectively, tracing sources of pollutants is of great importance and also is in urgent need. A variety of tracers have been developed such as isotopes, silica, bromide, and dyes; however, practical limitations of these traditional tracers still exist such as lack of multiplexed, multipoint tracing and interference of background noise. To overcome these limitations, a new tracing system based on DNA nanomaterials, namely DNA tracer, has already been developed. DNA tracers possess remarkable advantages including sufficient species, specificity, environmental friendly, stable migration, and high sensitivity as well as allowing for multipoints tracing. In this review article, we introduce the molecular design, synthesis, protection and signal readout strategies of DNA tracers, compare the advantages and disadvantages of DNA tracer with traditional tracers, and summarize the-state-of-art applications in hydrological environment investigations. In the end, we provide our perspective on the future development of DNA tracers.

Amplified OTDR systems for multipoint corrosion monitoring.

PubMed

Nascimento, Jehan F; Silva, Marcionilo J; Coêlho, Isnaldo J S; Cipriano, Eliel; Martins-Filho, Joaquim F

2012-01-01

We present two configurations of an amplified fiber-optic-based corrosion sensor using the optical time domain reflectometry (OTDR) technique as the interrogation method. The sensor system is multipoint, self-referenced, has no moving parts and can measure the corrosion rate several kilometers away from the OTDR equipment. The first OTDR monitoring system employs a remotely pumped in-line EDFA and it is used to evaluate the increase in system reach compared to a non-amplified configuration. The other amplified monitoring system uses an EDFA in booster configuration and we perform corrosion measurements and evaluations of system sensitivity to amplifier gain variations. Our experimental results obtained under controlled laboratory conditions show the advantages of the amplified system in terms of longer system reach with better spatial resolution, and also that the corrosion measurements obtained from our system are not sensitive to 3 dB gain variations.

Amplified OTDR Systems for Multipoint Corrosion Monitoring

PubMed Central

Nascimento, Jehan F.; Silva, Marcionilo J.; Coêlho, Isnaldo J. S.; Cipriano, Eliel; Martins-Filho, Joaquim F.

2012-01-01

We present two configurations of an amplified fiber-optic-based corrosion sensor using the optical time domain reflectometry (OTDR) technique as the interrogation method. The sensor system is multipoint, self-referenced, has no moving parts and can measure the corrosion rate several kilometers away from the OTDR equipment. The first OTDR monitoring system employs a remotely pumped in-line EDFA and it is used to evaluate the increase in system reach compared to a non-amplified configuration. The other amplified monitoring system uses an EDFA in booster configuration and we perform corrosion measurements and evaluations of system sensitivity to amplifier gain variations. Our experimental results obtained under controlled laboratory conditions show the advantages of the amplified system in terms of longer system reach with better spatial resolution, and also that the corrosion measurements obtained from our system are not sensitive to 3 dB gain variations. PMID:22737017

Quantum coordinated multi-point communication based on entanglement swapping

NASA Astrophysics Data System (ADS)

Du, Gang; Shang, Tao; Liu, Jian-wei

2017-05-01

In a quantum network, adjacent nodes can communicate with each other point to point by using pre-shared Einsten-Podolsky-Rosen (EPR) pairs, and furthermore remote nodes can establish entanglement channels by using quantum routing among intermediate nodes. However, with the rapid development of quantum networks, the demand of various message transmission among nodes inevitably emerges. In order to realize this goal and extend quantum networks, we propose a quantum coordinated multi-point communication scheme based on entanglement swapping. The scheme takes full advantage of EPR pairs between adjacent nodes and performs multi-party entanglement swapping to transmit messages. Considering various demands of communication, all nodes work cooperatively to realize different message transmission modes, including one to many, many to one and one to some. Scheme analysis shows that the proposed scheme can flexibly organize a coordinated group and efficiently use EPR resources, while it meets basic security requirement under the condition of coordinated communication.

Two-wavelength quadrature multipoint detection of partial discharge in power transformers using fiber Fabry-Perot acoustic sensors

NASA Astrophysics Data System (ADS)

Dong, Bo; Han, Ming; Wang, Anbo

2012-06-01

A reliable and low-cost two-wavelength quadrature interrogating method has been developed to demodulate optical signals from diaphragm-based Fabry-Perot interferometric fiber optic sensors for multipoint partial discharge detection in power transformers. Commercial available fused-silica parts (a wafer, a fiber ferrule, and a mating sleeve) and a cleaved optical single mode fiber were bonded together to form an extrinsic Fabry-Perot acoustic sensor. Two lasers with center wavelengths separated by a quarter of the period of sensor interference fringes were used to probe acousticwave- induced diaphragm vibration. A coarse wavelength-division multiplexing (CWDM) add/drop multiplexer was used to separate the reflected two wavelengths before two photo detectors. Optical couplers were used to distribute mixed laser light to each sensor-detector module for multiplexing purpose. Sensor structure, detection system design and experiment results are presented.

Graviton multipoint amplitudes for higher-derivative gravity in anti-de Sitter space

NASA Astrophysics Data System (ADS)

Shawa, M. M. W.; Medved, A. J. M.

2018-04-01

We calculate graviton multipoint amplitudes in an anti-de Sitter black brane background for higher-derivative gravity of arbitrary order in numbers of derivatives. The calculations are performed using tensor graviton modes in a particular regime of comparatively high energies and large scattering angles. The regime simplifies the calculations but, at the same time, is well suited for translating these results into the language of the dually related gauge theory. After considering theories whose Lagrangians consist of contractions of up to four Riemann tensors, we generalize to even higher-derivative theories by constructing a "basis" for the relevant scattering amplitudes. This construction enables one to find the basic form of the n -point amplitude for arbitrary n and any number of derivatives. Additionally, using the four-point amplitudes for theories whose Lagrangians carry contractions of either three or four Riemann tensors, we reexpress the scattering properties in terms of the Mandelstam variables.

Multipoint connectivity analysis of the May 2007 solar energetic particle events

NASA Astrophysics Data System (ADS)

Chollet, E. E.; Mewaldt, R. A.; Cummings, A. C.; Gosling, J. T.; Haggerty, D. K.; Hu, Q.; Larson, D.; Lavraud, B.; Leske, R. A.; Opitz, A.; Roelof, E. C.; Russell, C. T.; Sauvaud, J.-A.

2010-12-01

In May of 2007, the STEREO Ahead and Behind spacecraft, along with the ACE spacecraft situated between the two STEREO spacecraft, observed two small solar energetic particle (SEP) events. STEREO-A and -B observed nearly identical time profiles in the 19 May event, but in the 23 May event, the protons arrived significantly earlier at STEREO-A than at STEREO-B and the time-intensity profiles were markedly different. We present SEP anisotropy, suprathermal electron pitch angle and solar wind data to demonstrate distortion in the magnetic field topology produced by the passage of multiple interplanetary coronal mass ejections on 22 and 23 May, causing the two spacecraft to magnetically connect to different points back at the Sun. This pair of events illustrates the power of multipoint observations in detailed interpretation of complex events, since only a small shift in observer location results in different magnetic field line connections and different SEP time-intensity profiles.

Parallel multipoint recording of aligned and cultured neurons on corresponding Micro Channel Array toward on-chip cell analysis.

PubMed

Tonomura, W; Moriguchi, H; Jimbo, Y; Konishi, S

2008-01-01

This paper describes an advanced Micro Channel Array (MCA) so as to record neuronal network at multiple points simultaneously. Developed MCA is designed for neuronal network analysis which has been studied by co-authors using MEA (Micro Electrode Arrays) system. The MCA employs the principle of the extracellular recording. Presented MCA has the following advantages. First of all, the electrodes integrated around individual micro channels are electrically isolated for parallel multipoint recording. Sucking and clamping of cells through micro channels is expected to improve the cellular selectivity and S/N ratio. In this study, hippocampal neurons were cultured on the developed MCA. As a result, the spontaneous and evoked spike potential could be recorded by sucking and clamping the cells at multiple points. Herein, we describe the successful experimental results together with the design and fabrication of the advanced MCA toward on-chip analysis of neuronal network.

Polyaniline deposition on tilted fiber Bragg grating for pH sensing

NASA Astrophysics Data System (ADS)

Lopez Aldaba, A.; González-Vila, Á.; Debliquy, M.; Lopez-Amo, M.; Caucheteur, C.; Lahem, D.

2017-04-01

In this paper, we present the results of a new pH sensor based on a polyaniline (PAni) coating on the surface of a tilted fiber Bragg grating. The pH-sensitive PAni was deposited by in situ chemical oxidative polymerization. The performance of the fabricated pH sensor was tested and the obtained pH values were compared with the results obtained using a pH meter device. It was found that the sensor exhibits response to pH changes in the range of 2-12, achieving a sensitivity of 46 pm/pH with a maximum error due to the hysteresis effect of +/-1.14 pH. The main advantages of this PAni-TFBG pH sensor are biochemical compatibility, temperature independence, long-term stability and remote realtime multipoint sensing features. This type of sensor could be used for biochemical applications, pipeline corrosion monitoring or remote-multipoint measurements.

Fabrication of multipoint side-firing optical fiber by laser micro-ablation.

PubMed

Nguyen, Hoang; Parvez Arnob, Md Masud; Becker, Aaron T; Wolfe, John C; Hogan, Matthew K; Horner, Philip J; Shih, Wei-Chuan

2017-05-01

A multipoint, side-firing design enables an optical fiber to output light at multiple desired locations along the fiber body. This provides advantages over traditional end-to-end fibers, especially in applications requiring fiber bundles such as brain stimulation or remote sensing. This Letter demonstrates that continuous wave (CW) laser micro-ablation can controllably create conical-shaped cavities, or side windows, for outputting light. The dimensions of these cavities determine the amount of firing light and their firing angle. Experimental data show that a single side window on a 730 μm fiber can deliver more than 8% of the input light. This can be increased to more than 19% on a 65 μm fiber with side windows created using femtosecond laser ablation and chemical etching. Fine control of light distribution along an optical fiber is critical for various biomedical applications such as light-activated drug-release and optogenetics studies.

VPLS: an effective technology for building scalable transparent LAN services

NASA Astrophysics Data System (ADS)

Dong, Ximing; Yu, Shaohua

2005-02-01

Virtual Private LAN Service (VPLS) is generating considerable interest with enterprises and service providers as it offers multipoint transparent LAN service (TLS) over MPLS networks. This paper describes an effective technology - VPLS, which links virtual switch instances (VSIs) through MPLS to form an emulated Ethernet switch and build Scalable Transparent Lan Services. It first focuses on the architecture of VPLS with Ethernet bridging technique at the edge and MPLS at the core, then it tries to elucidate the data forwarding mechanism within VPLS domain, including learning and aging MAC addresses on a per LSP basis, flooding of unknown frames and replication for unknown, multicast, and broadcast frames. The loop-avoidance mechanism, known as split horizon forwarding, is also analyzed. Another important aspect of VPLS service is its basic operation, including autodiscovery and signaling, is discussed. From the perspective of efficiency and scalability the paper compares two important signaling mechanism, BGP and LDP, which are used to set up a PW between the PEs and bind the PWs to a particular VSI. With the extension of VPLS and the increase of full mesh of PWs between PE devices (n*(n-1)/2 PWs in all, a n2 complete problem), VPLS instance could have a large number of remote PE associations, resulting in an inefficient use of network bandwidth and system resources as the ingress PE has to replicate each frame and append MPLS labels for remote PE. So the latter part of this paper focuses on the scalability issue: the Hierarchical VPLS. Within the architecture of HVPLS, this paper addresses two ways to cope with a possibly large number of MAC addresses, which make VPLS operate more efficiently.

Mathematical simulation of thermocouple characteristics

NASA Astrophysics Data System (ADS)

Abouellail, A. A.; Kostina, M. A.; Bortalevich, S. I.; Loginov, E. L.; Shinyakov, Y. A.; Sukhorukov, M. P.

2018-03-01

Within this article, the investigation of the electrical characteristics of two thermocouples in parallel connection was mathematically simulated for further research of the effect of multi-point contact between the sensing thermocouple electrodes and the inspected sample in thermoelectric inspection devices.

Multisites Coordination in Shared Multicast Trees

DTIC Science & Technology

1999-01-01

conferencing, distributed interactive simulations, and collaborative systems. We de- scribe a novel protocol to coordinate multipoint groupwork in the IP...multicast framework. The pro- tocol supports Internet-wide coordination for large and highly-interactive groupwork , relying on trans- mission of

Fabrication and Optimization of Bilayered Nanoporous Anodic Alumina Structures as Multi-Point Interferometric Sensing Platform

PubMed Central

Nemati, Mahdieh; Santos, Abel

2018-01-01

Herein, we present an innovative strategy for optimizing hierarchical structures of nanoporous anodic alumina (NAA) to advance their optical sensing performance toward multi-analyte biosensing. This approach is based on the fabrication of multilayered NAA and the formation of differential effective medium of their structure by controlling three fabrication parameters (i.e., anodization steps, anodization time, and pore widening time). The rationale of the proposed concept is that interferometric bilayered NAA (BL-NAA), which features two layers of different pore diameters, can provide distinct reflectometric interference spectroscopy (RIfS) signatures for each layer within the NAA structure and can therefore potentially be used for multi-point biosensing. This paper presents the structural fabrication of layered NAA structures, and the optimization and evaluation of their RIfS optical sensing performance through changes in the effective optical thickness (EOT) using quercetin as a model molecule. The bilayered or funnel-like NAA structures were designed with the aim of characterizing the sensitivity of both layers of quercetin molecules using RIfS and exploring the potential of these photonic structures, featuring different pore diameters, for simultaneous size-exclusion and multi-analyte optical biosensing. The sensing performance of the prepared NAA platforms was examined by real-time screening of binding reactions between human serum albumin (HSA)-modified NAA (i.e., sensing element) and quercetin (i.e., analyte). BL-NAAs display a complex optical interference spectrum, which can be resolved by fast Fourier transform (FFT) to monitor the EOT changes, where three distinctive peaks were revealed corresponding to the top, bottom, and total layer within the BL-NAA structures. The spectral shifts of these three characteristic peaks were used as sensing signals to monitor the binding events in each NAA pore in real-time upon exposure to different concentrations of quercetin. The multi-point sensing performance of BL-NAAs was determined for each pore layer, with an average sensitivity and low limit of detection of 600 nm (mg mL−1)−1 and 0.14 mg mL−1, respectively. BL-NAAs photonic structures have the capability to be used as platforms for multi-point RIfS sensing of biomolecules that can be further extended for simultaneous size-exclusion separation and multi-analyte sensing using these bilayered nanostructures. PMID:29415436

Efficient Group Coordination in Multicast Trees

DTIC Science & Technology

2001-01-01

describe a novel protocol to coordinate multipoint groupwork within the IP-multicast framework. The protocol supports Internet-wide coordination for large...and highly-interactive groupwork , relying on the dissemination of coordination directives among group members across a shared end-to-end multicast

Simple-to-prepare multipoint field emitter

NASA Astrophysics Data System (ADS)

Sominskii, G. G.; Taradaev, E. P.; Tumareva, T. A.; Mishin, M. V.; Kornishin, S. Yu.

2015-07-01

We investigate multitip field emitters prepared by electroerosion treatment of the surface of molybdenum samples. Their characteristics are determined for operation with a protecting activated fullerene coating. Our experiments indicate that such cathodes are promising for high-voltage electron devices operating in technical vacuum.

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

PubMed Central

Coussens, Nathan P.; Hayashi, Ryo; Brown, Patrick H.; Balagopalan, Lakshmi; Balbo, Andrea; Akpan, Itoro; Houtman, Jon C. D.; Barr, Valarie A.; Schuck, Peter; Appella, Ettore

2013-01-01

The adapter molecules SLP-76 and LAT play central roles in T cell activation by recruiting enzymes and other adapters into multiprotein complexes that coordinate highly regulated signal transduction pathways. While many of the associated proteins have been characterized, less is known concerning the mechanisms of assembly for these dynamic and potentially heterogeneous signaling complexes. Following T cell receptor (TCR) stimulation, SLP-76 is found in structures called microclusters, which contain many signaling complexes. Previous studies showed that a mutation to the SLP-76 C-terminal SH2 domain nearly abolished SLP-76 microclusters, suggesting that the SH2 domain facilitates incorporation of signaling complexes into microclusters. S. C. Bunnell, A. L. Singer, D. I. Hong, B. H. Jacque, M. S. Jordan, M. C. Seminario, V. A. Barr, G. A. Koretzky, and L. E. Samelson, Mol. Cell. Biol., 26:7155–7166, 2006). Using biophysical methods, we demonstrate that the adapter, ADAP, contains three binding sites for SLP-76, and that multipoint binding to ADAP fragments oligomerizes the SLP-76 SH2 domain in vitro. These results were complemented with confocal imaging and functional studies of cells expressing ADAP with various mutations. Our results demonstrate that all three binding sites are critical for SLP-76 microcluster assembly, but any combination of two sites will partially induce microclusters. These data support a model whereby multipoint binding of SLP-76 to ADAP facilitates the assembly of SLP-76 microclusters. This model has implications for the regulation of SLP-76 and LAT microclusters and, as a result, T cell signaling. PMID:23979596

Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

PubMed

Coussens, Nathan P; Hayashi, Ryo; Brown, Patrick H; Balagopalan, Lakshmi; Balbo, Andrea; Akpan, Itoro; Houtman, Jon C D; Barr, Valarie A; Schuck, Peter; Appella, Ettore; Samelson, Lawrence E

2013-11-01

The adapter molecules SLP-76 and LAT play central roles in T cell activation by recruiting enzymes and other adapters into multiprotein complexes that coordinate highly regulated signal transduction pathways. While many of the associated proteins have been characterized, less is known concerning the mechanisms of assembly for these dynamic and potentially heterogeneous signaling complexes. Following T cell receptor (TCR) stimulation, SLP-76 is found in structures called microclusters, which contain many signaling complexes. Previous studies showed that a mutation to the SLP-76 C-terminal SH2 domain nearly abolished SLP-76 microclusters, suggesting that the SH2 domain facilitates incorporation of signaling complexes into microclusters. S. C. Bunnell, A. L. Singer, D. I. Hong, B. H. Jacque, M. S. Jordan, M. C. Seminario, V. A. Barr, G. A. Koretzky, and L. E. Samelson, Mol. Cell. Biol., 26:7155-7166, 2006). Using biophysical methods, we demonstrate that the adapter, ADAP, contains three binding sites for SLP-76, and that multipoint binding to ADAP fragments oligomerizes the SLP-76 SH2 domain in vitro. These results were complemented with confocal imaging and functional studies of cells expressing ADAP with various mutations. Our results demonstrate that all three binding sites are critical for SLP-76 microcluster assembly, but any combination of two sites will partially induce microclusters. These data support a model whereby multipoint binding of SLP-76 to ADAP facilitates the assembly of SLP-76 microclusters. This model has implications for the regulation of SLP-76 and LAT microclusters and, as a result, T cell signaling.

Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study.

PubMed

Arya, Rector; Lehman, Donna; Hunt, Kelly J; Schneider, Jennifer; Almasy, Laura; Blangero, John; Stern, Michael P; Duggirala, Ravindranath

2003-12-31

Epidemiological studies have indicated that obesity and low high-density lipoprotein (HDL) levels are strong cardiovascular risk factors, and that these traits are inversely correlated. Despite the belief that these traits are correlated in part due to pleiotropy, knowledge on specific genes commonly affecting obesity and dyslipidemia is very limited. To address this issue, we first conducted univariate multipoint linkage analysis for body mass index (BMI) and HDL-C to identify loci influencing variation in these phenotypes using Framingham Heart Study data relating to 1702 subjects distributed across 330 pedigrees. Subsequently, we performed bivariate multipoint linkage analysis to detect common loci influencing covariation between these two traits. We scanned the genome and identified a major locus near marker D6S1009 influencing variation in BMI (LOD = 3.9) using the program SOLAR. We also identified a major locus for HDL-C near marker D2S1334 on chromosome 2 (LOD = 3.5) and another region near marker D6S1009 on chromosome 6 with suggestive evidence for linkage (LOD = 2.7). Since these two phenotypes have been independently mapped to the same region on chromosome 6q, we used the bivariate multipoint linkage approach using SOLAR. The bivariate linkage analysis of BMI and HDL-C implicated the genetic region near marker D6S1009 as harboring a major gene commonly influencing these phenotypes (bivariate LOD = 6.2; LODeq = 5.5) and appears to improve power to map the correlated traits to a region, precisely. We found substantial evidence for a quantitative trait locus with pleiotropic effects, which appears to influence both BMI and HDL-C phenotypes in the Framingham data.

Development of an FPGA-based multipoint laser pyroshock measurement system for explosive bolts

NASA Astrophysics Data System (ADS)

Abbas, Syed Haider; Jang, Jae-Kyeong; Lee, Jung-Ryul; Kim, Zaeill

2016-07-01

Pyroshock can cause failure to the objective of an aerospace structure by damaging its sensitive electronic equipment, which is responsible for performing decisive operations. A pyroshock is the high intensity shock wave that is generated when a pyrotechnic device is explosively triggered to separate, release, or activate structural subsystems of an aerospace architecture. Pyroshock measurement plays an important role in experimental simulations to understand the characteristics of pyroshock on the host structure. This paper presents a technology to measure a pyroshock wave at multiple points using laser Doppler vibrometers (LDVs). These LDVs detect the pyroshock wave generated due to an explosive-based pyrotechnical event. Field programmable gate array (FPGA) based data acquisition is used in the study to acquire pyroshock signals simultaneously from multiple channels. This paper describes the complete system design for multipoint pyroshock measurement. The firmware architecture for the implementation of multichannel data acquisition on an FPGA-based development board is also discussed. An experiment using explosive bolts was configured to test the reliability of the system. Pyroshock was generated using explosive excitation on a 22-mm-thick steel plate. Three LDVs were deployed to capture the pyroshock wave at different points. The pyroshocks captured were displayed as acceleration plots. The results showed that our system effectively captured the pyroshock wave with a peak-to-peak magnitude of 303 741 g. The contribution of this paper is a specialized architecture of firmware design programmed in FPGA for data acquisition of large amount of multichannel pyroshock data. The advantages of the developed system are the near-field, multipoint, non-contact, and remote measurement of a pyroshock wave, which is dangerous and expensive to produce in aerospace pyrotechnic tests.

Molecular analysis and genetic mapping of the rhodopsin gene in families with autosomal dominant retinitis pigmentosa

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bunge, S.; Wedemann, H.; Samanns, C.

1993-07-01

Eighty-eight patients/families with autosomal dominant retinitis pigmentosa (RP) were screened for rhodopsin mutations. Direct sequencing revealed 13 different mutations in a total of 14 (i.e., 16%) unrelated patients. Five of these mutations (T4K, Q28H, R135G, F220C, and C222R) have not been reported so far. In addition, multipoint linkage analysis was performed on two large families with autosomal dominant RP due to rhodopsin mutations by using five DNA probes from 3q21-q24. No tight linkage was found between the rhodopsin locus (RHO) and D3S47 ([theta][sub max] = 0.08). By six-point analysis, RHO was localized in the region between D3S21 and D3S47, withmore » a maximum lod score of 13.447 directly at D3S20. 13 refs., 1 fig., 2 tabs.« less

X-linked borderline mental retardation with prominent behavioral disturbance: Phenotype, genetic localization, and evidence for disturbed monoamine metabolism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brunner, H.G.; Nelen, M.R.; Zandvoort, P. van

The authors have identified a large Dutch kindred with a new form of X-linked nondysmorphic mild mental retardation. All affected males in this family show very characteristic abnormal behavior, in particular aggressive and sometimes violent behavior. Other types of impulsive behavior include arson, attempted rape, and exhibitionism. Attempted suicide has been reported in a single case. The locus for this disorder could be assigned to the Xp11-21 interval between DXS7 and DXS77 by linkage analysis using markers spanning the X chromosome. A maximal multipoint lod score of 3.69 was obtained at the monoamine oxidase type A (MAOA) monoamine metabolism. Thesemore » data are compatible with a primary defect in the structural gene for MAOA and/or monoamine oxidase type B (MAOB). Normal platelet MAOB activity suggests that the unusual behavior pattern in this family may be caused by isolated MAOA deficiency. 34 refs., 4 figs., 4 tabs.« less

MMS Multipoint Electric Field Observations of Small-Scale Magnetic Holes

NASA Technical Reports Server (NTRS)

Goodrich, Katherine A.; Ergun, Robert E.; Wilder, Frederick; Burch, James; Torbert, Roy; Khotyaintsev, Yuri; Lindqvist, Per-Arne; Russell, Christopher; Strangeway, Robert; Magnus, Werner

2016-01-01

Small-scale magnetic holes (MHs), local depletions in magnetic field strength, have been observed multiple times in the Earths magnetosphere in the bursty bulk flow (BBF) braking region. This particular subset of MHs has observed scale sizes perpendicular to the background magnetic field (B) less than the ambient ion Larmor radius (p(sib i)). Previous observations by Time History of Events and Macroscale Interactions during Substorms (THEMIS) indicate that this subset of MHs can be supported by a current driven by the E x B drift of electrons. Ions do not participate in the E x B drift due to the small-scale size of the electric field. While in the BBF braking region, during its commissioning phase, the Magnetospheric Multiscale (MMS) spacecraft observed a small-scale MH. The electric field observations taken during this event suggest the presence of electron currents perpendicular to the magnetic field. These observations also suggest that these currents can evolve to smaller spatial scales.

A wearable multipoint ultrasonic travel aids for visually impaired

NASA Astrophysics Data System (ADS)

Ercoli, Ilaria; Marchionni, Paolo; Scalise, Lorenzo

2013-09-01

In 2010, the World Health Organization estimates that there were about 285 million people in the world with disabling eyesight loss (246 millions are visually impaired (VI) and 39 millions are totally blind). For such users, hits during mobility tasks are the reason of major concerns and can reduce the quality of their life. The white cane is the primary device used by the majority of blind or VI users to explore and possibly avoid obstacles; it can monitor only the ground (< 1m) and it does not provide protection for the legs, the trunk and the head. In this paper, authors propose a novel stand-alone Electronic Travel Aid (ETA) device for obstacle detection based on multi- sensing (by 4 ultrasonic transducers) and a microcontroller. Portability, simplicity, reduced dimensions and cost are among the major pros of the reported system, which can detect and localize (angular position and distance from the user) obstacles eventually present in the volume in front of him and on the ground in front of him.

The Juberg-Marsidi syndrome maps to the proximal long arm of the X chromosome (Xq12-q21)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saugier-Veber, P.; Abadie, V.; Turleau, C.

Juberg-Marsidi syndrome (McKusick 309590) is a rare X-linked recessive condition characterized by severe mental retardation, growth failure, sensorineural deafness, and microgenitalism. Here the authors report on the genetic mapping of the Juberg-Marsidi gene to the proximal long arm of the X chromosome (Xq12-q21) by linkage to probe pRX214H1 at the DXS441 locus (Z = 3.24 at [theta] = .00). Multipoint linkage analysis placed the Juberg-Marsidi gene within the interval defined by the DXS159 and the DXYS1X loci in the Xq12-q21 region. These data provide evidence for the genetic distinction between Juberg-Marsidi syndrome and several other X-linked mental retardation syndromes thatmore » have hypogonadism and hypogenitalism and that have been localized previously. Finally, the mapping of the Juberg-Marsidi gene is of potential interest for reliable genetic counseling of at-risk women. 25 refs., 2 figs., 3 tabs.« less

AFFECTS - Advanced Forecast For Ensuring Communications Through Space

NASA Astrophysics Data System (ADS)

Bothmer, Volker

2013-04-01

Through the AFFECTS project funded by the European Union's 7th Framework Programme, European and US scientists develop an advanced proto-type space weather warning system to safeguard the operation of telecommunication and navigation systems on Earth to the threat of solar storms. The project is led by the University of Göttingen's Institute for Astrophysics and comprises worldwide leading research and academic institutions and industrial enterprises from Germany, Belgium, Ukraine, Norway and the United States. The key objectives of the AFFECTS project are: State-of-the-art analysis and modelling of the Sun-Earth chain of effects on the Earth's ionosphere and their subsequent impacts on communication systems based on multipoint space observations and complementary ground-based data. Development of a prototype space weather early warning system and reliable space weather forecasts, with specific emphasis on ionospheric applications. Dissemination of new space weather products and services to end users, the scientific community and general public. The presentation summarizes the project highlights, with special emphasis on the developed space weather forecast tools.

Radial resolution enhancement of the NSTX Thomson scattering diagnostic.

PubMed

LeBlanc, B P; Diallo, A; Labik, G; Stevens, D R

2012-10-01

Current magnetic confinement plasma physics research has increased the demand for radial resolution in profile diagnostics, in particular in the edge and pedestal regions. On NSTX, an upgrade of the existing multi-point Thomson scattering diagnostic has been implemented in order to respond to the research program needs. Twelve new radial channels have been added bringing the total number of positions to 42. Four previously un-instrumented fiber bundles were put in service. Eight existing "active" fiber bundles were divided in two sub-bundles each in order to increase spatial resolution. Twelve radial channels now cover the pedestal region with a resolution near one centimeter. Fifteen radial channels cover the core and internal transport barrier regions. Two additional channels were added, one near the inner edge and one in the outer scrape-off layer. The intersection of the focused viewing optics field of view with a finite-width laser beam results in major-radius cross talk between adjacent fiber sub-bundles. A discussion and calculation of the cross talk will be presented.

Optimal Ventilation Control in Complex Urban Tunnels with Multi-Point Pollutant Discharge

DOT National Transportation Integrated Search

2017-10-01

Zhen Tan (ORCID ID 0000-0003-1711-3557) H. Oliver Gao (ORCID ID 0000-0002-7861-9634) We propose an optimal ventilation control model for complex urban vehicular tunnels with distributed pollutant discharge points. The control problem is formulated as...

A Low NO(x) Lean-Direct Injection, Multipoint Integrated Module Combuster Concept for Advanced Aircraft Gas Turbines

NASA Technical Reports Server (NTRS)

Tacina, Robert; Wey, Changlie; Laing, Peter; Mansour, Adel

2002-01-01

A low NO(x) emissions combustor has been demonstrated in flame-tube tests. A multipoint, lean-direct injection concept was used. Configurations were tested that had 25- and 36- fuel injectors in the size of a conventional single fuel injector. An integrated-module approach was used for the construction where chemically etched laminates, diffusion bonded together, combine the fuel injectors, air swirlers and fuel manifold into a single element. Test conditions were inlet temperatures up to 810 K, inlet pressures up to 2760 kPa, and flame temperatures up to 2100 K. A correlation was developed relating the NO(x) emissions with the inlet temperature, inlet pressure, fuel-air ratio and pressure drop. Assuming that 10 percent of the combustion air would be used for liner cooling and using a hypothetical engine cycle, the NO(x) emissions using the correlation from flame-tube tests were estimated to be less than 20 percent of the 1996 ICAO standard.

A novel, cost-effective, multi-point Thomson scattering system on the Pegasus Toroidal Experiment (invited)

DOE PAGES

Schlossberg, David J.; Bodner, Grant M.; Bongard, Michael W.; ...

2016-09-16

Here, a novel, cost-effective, multi-point Thomson scattering system has been designed, implemented, and operated on the Pegasus Toroidal Experiment. Leveraging advances in Nd:YAG lasers, high-efficiency volume phase holographic transmission gratings, and increased quantum-efficiency Generation 3 image-intensified charge coupled device (ICCD) cameras, the system provides Thomson spectra at eight spatial locations for a single grating/camera pair. The on-board digitization of the ICCD camera enables easy modular expansion, evidenced by recent extension from 4 to 12 plasma/background spatial location pairs. Stray light is rejected using time-of-flight methods suited to gated ICCDs, and background light is blocked during detector readout by a fastmore » shutter. This –10 3 reduction in background light enables further expansion to up to 24 spatial locations. The implementation now provides single-shot T e(R) for n e > 5 × 10 18 m –3.« less

Linkage analysis in a Dutch family with X-linked recessive congenital stationary night blindness (XL-CSNB).

PubMed

Berger, W; van Duijnhoven, G; Pinckers, A; Smits, A; Ropers, H H; Cremers, F

1995-01-01

Linkage analysis has been performed in a large Dutch pedigree with X-linked recessive congenital stationary night blindness (CSNB) by utilizing 16 DNA markers from the proximal short arm of the human X chromosome (Xp21.1-11.2). Thirteen polymorphic markers are at least partially informative and have enabled pairwise and multipoint linkage analysis. For three loci, i.e. DXS228, the monoamine oxidase B gene and the Norrie disease gene (NDG), multipoint linkage studies have yielded maximum lod scores of > 3.0 at a recombination fraction of zero. Analysis of recombination events has enabled us to rule out the possibility that the underlying defect in this family is allelic to RP3; the gene defect could also be excluded from the proximal part of the region known to carry RP2. Linkage data are consistent with a possible involvement of the NDG but mutations in the open reading frame of this gene have not been found.

Morphing Wings: A Study Using High-Fidelity Aerodynamic Shape Optimization

NASA Astrophysics Data System (ADS)

Curiale, Nathanael J.

With the aviation industry under pressure to reduce fuel consumption, morphing wings have the capacity to improve aircraft performance, thereby making a significant contribution to reversing climate change. Through high-fidelity aerodynamic shape optimization, various forms of morphing wings are assessed for a hypothetical regional-class aircraft. The framework used solves the Reynolds-averaged Navier-Stokes equations and utilizes a gradient-based optimization algorithm. Baseline geometries are developed through multipoint optimization, where the average drag coefficient is minimized over a range of flight conditions with additional dive constraints. Morphing optimizations are then performed, beginning with these baseline shapes. Five distinct types of morphing are investigated and compared. Overall, a theoretical fully adaptable wing produces roughly a 2% improvement in average performance, whereas trailing-edge morphing with a 27-point multipoint baseline results in just over a 1% improvement in average performance. Trailing-edge morphing proves to be more beneficial than leading-edge morphing, upper-surface morphing, and a conventional flap.

A Bionic Camera-Based Polarization Navigation Sensor

PubMed Central

Wang, Daobin; Liang, Huawei; Zhu, Hui; Zhang, Shuai

2014-01-01

Navigation and positioning technology is closely related to our routine life activities, from travel to aerospace. Recently it has been found that Cataglyphis (a kind of desert ant) is able to detect the polarization direction of skylight and navigate according to this information. This paper presents a real-time bionic camera-based polarization navigation sensor. This sensor has two work modes: one is a single-point measurement mode and the other is a multi-point measurement mode. An indoor calibration experiment of the sensor has been done under a beam of standard polarized light. The experiment results show that after noise reduction the accuracy of the sensor can reach up to 0.3256°. It is also compared with GPS and INS (Inertial Navigation System) in the single-point measurement mode through an outdoor experiment. Through time compensation and location compensation, the sensor can be a useful alternative to GPS and INS. In addition, the sensor also can measure the polarization distribution pattern when it works in multi-point measurement mode. PMID:25051029

Composite, all-ceramics, high-peak power Nd:YAG/Cr(4+):YAG monolithic micro-laser with multiple-beam output for engine ignition.

PubMed

Pavel, Nicolaie; Tsunekane, Masaki; Taira, Takunori

2011-05-09

A passively Q-switched Nd:YAG/Cr(4+):YAG micro-laser with three-beam output was realized. A single active laser source made of a composite, all-ceramics Nd:YAG/Cr(4+):YAG monolithic cavity was pumped by three independent lines. At 5 Hz repetition rate, each line delivered laser pulses with ~2.4 mJ energy and 2.8-MW peak power. The M(2) factor of a laser beam was 3.7, and stable air breakdowns were realized. The increase of pump repetition rate up to 100 Hz improved the laser pulse energy by 6% and required ~6% increase of the pump pulse energy. Pulse timing of the laser-array beams can by adjusted by less than 5% tuning of an individual line pump energy, and therefore simultaneous multi-point ignition is possible. This kind of laser can be used for multi-point ignition of an automobile engine. © 2011 Optical Society of America

Multi-point optimization of recirculation flow type casing treatment in centrifugal compressors

NASA Astrophysics Data System (ADS)

Tun, Min Thaw; Sakaguchi, Daisaku

2016-06-01

High-pressure ratio and wide operating range are highly required for a turbocharger in diesel engines. A recirculation flow type casing treatment is effective for flow range enhancement of centrifugal compressors. Two ring grooves on a suction pipe and a shroud casing wall are connected by means of an annular passage and stable recirculation flow is formed at small flow rates from the downstream groove toward the upstream groove through the annular bypass. The shape of baseline recirculation flow type casing is modified and optimized by using a multi-point optimization code with a metamodel assisted evolutionary algorithm embedding a commercial CFD code CFX from ANSYS. The numerical optimization results give the optimized design of casing with improving adiabatic efficiency in wide operating flow rate range. Sensitivity analysis of design parameters as a function of efficiency has been performed. It is found that the optimized casing design provides optimized recirculation flow rate, in which an increment of entropy rise is minimized at grooves and passages of the rotating impeller.

A coal mine multi-point fiber ethylene gas concentration sensor

NASA Astrophysics Data System (ADS)

Wei, Yubin; Chang, Jun; Lian, Jie; Liu, Tongyu

2015-03-01

Spontaneous combustion of the coal mine goaf is one of the main disasters in the coal mine. The detection technology based on symbolic gas is the main means to realize the spontaneous combustion prediction of the coal mine goaf, and ethylene gas is an important symbol gas of spontaneous combustion in the coal accelerated oxidation stage. In order to overcome the problem of current coal ethylene detection, the paper presents a mine optical fiber multi-point ethylene concentration sensor based on the tunable diode laser absorption spectroscopy. Based on the experiments and analysis of the near-infrared spectrum of ethylene, the system employed the 1.62 μm (DFB) wavelength fiber coupled distributed feedback laser as the light source. By using the wavelength scanning technique and developing a stable fiber coupled Herriot type long path gas absorption cell, a ppm-level high sensitivity detecting system for the concentration of ethylene gas was realized, which could meet the needs of coal mine fire prevention goaf prediction.

The Electrophysiological MEMS Device with Micro Channel Array for Cellular Network Analysis

NASA Astrophysics Data System (ADS)

Tonomura, Wataru; Kurashima, Toshiaki; Takayama, Yuzo; Moriguchi, Hiroyuki; Jimbo, Yasuhiko; Konishi, Satoshi

This paper describes a new type of MCA (Micro Channel Array) for simultaneous multipoint measurement of cellular network. Presented MCA employing the measurement principles of the patch-clamp technique is designed for advanced neural network analysis which has been studied by co-authors using 64ch MEA (Micro Electrode Arrays) system. First of all, sucking and clamping of cells through channels of developed MCA is expected to improve electrophysiological signal detections. Electrophysiological sensing electrodes integrated around individual channels of MCA by using MEMS (Micro Electro Mechanical System) technologies are electrically isolated for simultaneous multipoint measurement. In this study, we tested the developed MCA using the non-cultured rat's cerebral cortical slice and the hippocampal neurons. We could measure the spontaneous action potential of the slice simultaneously at multiple points and culture the neurons on developed MCA. Herein, we describe the experimental results together with the design and fabrication of the electrophysiological MEMS device with MCA for cellular network analysis.

A synchronized multipoint vision-based system for displacement measurement of civil infrastructures.

PubMed

Ho, Hoai-Nam; Lee, Jong-Han; Park, Young-Soo; Lee, Jong-Jae

2012-01-01

This study presents an advanced multipoint vision-based system for dynamic displacement measurement of civil infrastructures. The proposed system consists of commercial camcorders, frame grabbers, low-cost PCs, and a wireless LAN access point. The images of target panels attached to a structure are captured by camcorders and streamed into the PC via frame grabbers. Then the displacements of targets are calculated using image processing techniques with premeasured calibration parameters. This system can simultaneously support two camcorders at the subsystem level for dynamic real-time displacement measurement. The data of each subsystem including system time are wirelessly transferred from the subsystem PCs to master PC and vice versa. Furthermore, synchronization process is implemented to ensure the time synchronization between the master PC and subsystem PCs. Several shaking table tests were conducted to verify the effectiveness of the proposed system, and the results showed very good agreement with those from a conventional sensor with an error of less than 2%.

A Synchronized Multipoint Vision-Based System for Displacement Measurement of Civil Infrastructures

PubMed Central

Ho, Hoai-Nam; Lee, Jong-Han; Park, Young-Soo; Lee, Jong-Jae

2012-01-01

This study presents an advanced multipoint vision-based system for dynamic displacement measurement of civil infrastructures. The proposed system consists of commercial camcorders, frame grabbers, low-cost PCs, and a wireless LAN access point. The images of target panels attached to a structure are captured by camcorders and streamed into the PC via frame grabbers. Then the displacements of targets are calculated using image processing techniques with premeasured calibration parameters. This system can simultaneously support two camcorders at the subsystem level for dynamic real-time displacement measurement. The data of each subsystem including system time are wirelessly transferred from the subsystem PCs to master PC and vice versa. Furthermore, synchronization process is implemented to ensure the time synchronization between the master PC and subsystem PCs. Several shaking table tests were conducted to verify the effectiveness of the proposed system, and the results showed very good agreement with those from a conventional sensor with an error of less than 2%. PMID:23028250

Three-dimensional imaging of absolute blood flow velocity and blood vessel position under low blood flow velocity based on Doppler signal information included in scattered light from red blood cells

NASA Astrophysics Data System (ADS)

Kyoden, Tomoaki; Akiguchi, Shunsuke; Tajiri, Tomoki; Andoh, Tsugunobu; Hachiga, Tadashi

2017-11-01

The development of a system for in vivo visualization of occluded distal blood vessels for diabetic patients is the main target of our research. We herein describe two-beam multipoint laser Doppler velocimetry (MLDV), which measures the instantaneous multipoint flow velocity and can be used to observe the blood flow velocity in peripheral blood vessels. By including a motorized stage to shift the measurement points horizontally and in the depth direction while measuring the velocity, the path of the blood vessel in the skin could be observed using blood flow velocity in three-dimensional space. The relationship of the signal power density between the blood vessel and the surrounding tissues was shown and helped us identify the position of the blood vessel. Two-beam MLDV can be used to simultaneously determine the absolute blood flow velocity distribution and identify the blood vessel position in skin.

Full Mesh Audio Conferencing Using the Point-to-Multipoint On-Board Switching Capability of ACTS

NASA Technical Reports Server (NTRS)

Rivett, Mary L.; Sethna, Zubin H.

1996-01-01

The purpose of this paper is to describe an implementation of audio conferencing using the ACTS T1-VSAT network. In particular, this implementation evaluates the use of the on-board switching capability of the satellite as a viable alternative for providing the multipoint connectivity normally provided by terrestrial audio bridge equipment The system that was implemented provides full mesh, full-duplex audio conferencing, with end-to-end voice paths between all participants requiring only a single hop (i.e. 250 msec. delay). Moreover, it addresses the lack of spontaneity in current systems by allowing a user to easily start a conference from any standard telephone handset connected to an ACTS earth station, and quickly add new members to the conference at any time using the 'hook flash' capability. No prior scheduling of resources is required and there is no central point of control, thereby providing the user with the spontaneity desired in audio conference control.

High-Resolution Measurement of the Turbulent Frequency-Wavenumber Power Spectrum in a Laboratory Magnetosphere

NASA Astrophysics Data System (ADS)

Qian, T. M.; Mauel, M. E.

2017-10-01

In a laboratory magnetosphere, plasma is confined by a strong dipole magnet, where interchange and entropy mode turbulence can be studied and controlled in near steady-state conditions. Whole-plasma imaging shows turbulence dominated by long wavelength modes having chaotic amplitudes and phases. Here, we report for the first time, high-resolution measurement of the frequency-wavenumber power spectrum by applying the method of Capon to simultaneous multi-point measurement of electrostatic entropy modes using an array of floating potential probes. Unlike previously reported measurements in which ensemble correlation between two probes detected only the dominant wavenumber, Capon's ``maximum likelihood method'' uses all available probes to produce a frequency-wavenumber spectrum, showing the existence of modes propagating in both electron and ion magnetic drift directions. We also discuss the wider application of this technique to laboratory and magnetospheric plasmas with simultaneous multi-point measurements. Supported by NSF-DOE Partnership in Plasma Science Grant DE-FG02-00ER54585.

RX and Z Mode Growth Rates and Propagation at Cavity Boundaries

NASA Astrophysics Data System (ADS)

Mutel, R. L.; Christopher, I. W.; Menietti, J. D.; Gurnett, D. A.; Pickett, J. S.; Masson, A.; Fazakerley, A.; Lucek, E.

Recent Cluster WBD observations in the Earth's auroral acceleration region have detected trapped Z mode auroral kilometric radiation while the spacecraft were entering a deep density cavity. The Z mode has a clear cutoff at the local upper hybrid resonance frequency, while RX mode radiation is detected above the RX mode cutoff frequency. The small gap between the upper hybrid resonance and the RX mode cutoff frequencies is proportional to the local electron density as expected from cold plasma theory. The width of the observed gap provides a new sensitive measure of the ambient electron density. In addition, the relative intensities of RX and Z mode radiation provide a sensitive probe of the plasma β = Ω_pe /Ω_ce at the source since the growth rates, although identical in form, have different ranges of allowed resonant radii which depend on β. In particular, the RX mode growth is favored for low β, while the Z mode is favored at higher β. The observed mode intensities and β's appear to be consistent with this model, and favor generation of Z mode at the source over models in which Z mode is generated by mode-conversion at cavity boundaries. These are the first multi-point direct measurements of mode-specific AKR propagation in the auroral acceleration region of any planet.

Temporal change of EIA asymmetry revealed by a beacon receiver network in Southeast Asia

NASA Astrophysics Data System (ADS)

Watthanasangmechai, Kornyanat; Yamamoto, Mamoru; Saito, Akinori; Maruyama, Takashi; Yokoyama, Tatsuhiro; Nishioka, Michi; Ishii, Mamoru

2015-05-01

To reveal the temporal change of the equatorial ionization anomaly (EIA) asymmetry, a multipoint satellite-ground beacon experiment was conducted along the meridional plane of the Thailand-Indonesia sector. The observation includes one station near the magnetic equator and four stations at off-equator latitudes. This is the first EIA asymmetry study with high spatial resolution using GNU Radio Beacon Receiver (GRBR) observations in Southeast Asia. GRBR-total electron contents (TECs) from 97 polar-orbit satellite passes in March 2012 were analyzed in this study. Successive passes captured rapid evolution of EIA asymmetry, especially during geomagnetic disturbances. The penetrating electric fields that occur during geomagnetic disturbed days are not the cause of the asymmetry. Instead, high background TEC associated with an intense electric field empowers the neutral wind to produce severe asymmetry of the EIA. Such rapid evolution of EIA asymmetry was not seen during nighttime, when meridional wind mainly controlled the asymmetric structures. Additional data are necessary to identify the source of the variations, i.e., atmospheric waves. Precisely capturing the locations of the crests and the evolution of the asymmetry enhances understanding of the temporal change of EIA asymmetry at the local scale and leads to a future local modeling for TEC prediction in Southeast Asia.

RECOVERING FILTER-BASED MICROARRAY DATA FOR PATHWAYS ANALYSIS USING A MULTIPOINT ALIGNMENT STRATEGY

EPA Science Inventory

The use of commercial microarrays are rapidly becoming the method of choice for profiling gene expression and assessing various disease states. Research Genetics has provided a series of well defined biological and software tools to the research community for these analyses. Th...

High pressure flow-rate switch

NASA Technical Reports Server (NTRS)

Gale, G. P.

1970-01-01

Flow-rate switch adjusts easily over a wide switching range and operates uniformly over many cycles. It adapts easily to control of various fluids and has the possibility of introducing multi-point switching. Novel design features include the tapered spool, balanced porting, capillary-bypass lubrication, and capillary-restriction damping.

Developing Telecommunication Linkages for Microcomputer-Aided Instruction. TDC Research Report No. 1.

ERIC Educational Resources Information Center

Blinn, Charles R.; And Others

A project undertaken at the University of Minnesota evaluated two microcomputer teletraining systems (audiographic conferencing) to determine the effectiveness of this technology for point-to-point and multipoint distance education. System design requirements included broadcast keystrokes, error checking, master-slave linkages, simultaneous voice…

Sector Tests of a Low-NO(sub x), Lean, Direct- Injection, Multipoint Integrated Module Combustor Concept Conducted

NASA Technical Reports Server (NTRS)

Tacina, Robert R.; Wey, Chang-Lie; Laing, Peter; Mansour, Adel

2002-01-01

The low-emissions combustor development described is directed toward advanced high pressure aircraft gas-turbine applications. The emphasis of this research is to reduce nitrogen oxides (NOx) at high-power conditions and to maintain carbon monoxide and unburned hydrocarbons at their current low levels at low power conditions. Low-NOx combustors can be classified into rich-burn and lean-burn concepts. Lean-burn combustors can be further classified into lean-premixed-prevaporized (LPP) and lean direct injection (LDI) concepts. In both concepts, all the combustor air, except for liner cooling flow, enters through the combustor dome so that the combustion occurs at the lowest possible flame temperature. The LPP concept has been shown to have the lowest NOx emissions, but for advanced high-pressure-ratio engines, the possibility of autoignition or flashback precludes its use. LDI differs from LPP in that the fuel is injected directly into the flame zone, and thus, it does not have the potential for autoignition or flashback and should have greater stability. However, since it is not premixed and prevaporized, good atomization is necessary and the fuel must be mixed quickly and uniformly so that flame temperatures are low and NOx formation levels are comparable to those of LPP. The LDI concept described is a multipoint fuel injection/multiburning zone concept. Each of the multiple fuel injectors has an air swirler associated with it to provide quick mixing and a small recirculation zone for burning. The multipoint fuel injection provides quick, uniform mixing and the small multiburning zones provide for reduced burning residence time, resulting in low NOx formation. An integrated-module approach was used for the construction where chemically etched laminates, diffusion bonded together, combine the fuel injectors, air swirlers, and fuel manifold into a single element. The multipoint concept combustor was demonstrated in a 15 sector test. The configuration tested had 36 fuel injectors and fuel-air mixers that replaced two fuel injectors in a conventional dual-annular combustor. During tests, inlet temperatures were up to 870 K and inlet pressures were up to 5400 kPa. A correlation was developed that related the NOx emissions with the inlet temperature, inlet pressure, fuel-air ratio, and pressure drop. At low-power conditions, fuel staging was used so that high combustion efficiency was obtained with only one-fourth of the fuel injectors flowing. The test facility had optical access, and visual images showed the flame to be very short, approximately 25 mm long.

Proceedings of the Workshop on Applications of Distributed System Theory to the Control of Large Space Structures

NASA Technical Reports Server (NTRS)

Rodriguez, G. (Editor)

1983-01-01

Two general themes in the control of large space structures are addressed: control theory for distributed parameter systems and distributed control for systems requiring spatially-distributed multipoint sensing and actuation. Topics include modeling and control, stabilization, and estimation and identification.

Optimization of connection techniques for multipoint satellite videoconference

NASA Astrophysics Data System (ADS)

Perrone, A.; Puccio, A.; Tirro, S.

1985-12-01

Videoconferencing is increasingly considered a convenient substitute for business travels, and satellites will remain for a long time the most convenient means for quick network implementation. The paper gives indications about the most promising connection and demand assignment techniques, and defines a possible protocol for information exchange among involved entities.

Contrasting dynamics of electrons and protons in the near-Earth plasma sheet during dipolarization

NASA Astrophysics Data System (ADS)

Malykhin, Andrey Y.; Grigorenko, Elena E.; Kronberg, Elena A.; Koleva, Rositza; Ganushkina, Natalia Y.; Kozak, Ludmila; Daly, Patrick W.

2018-05-01

The fortunate location of Cluster and the THEMIS P3 probe in the near-Earth plasma sheet (PS) (at X ˜ -7-9 RE) allowed for the multipoint analysis of properties and spectra of electron and proton injections. The injections were observed during dipolarization and substorm current wedge formation associated with braking of multiple bursty bulk flows (BBFs). In the course of dipolarization, a gradual growth of the BZ magnetic field lasted ˜ 13 min and it was comprised of several BZ pulses or dipolarization fronts (DFs) with duration ≤ 1 min. Multipoint observations have shown that the beginning of the increase in suprathermal ( > 50 keV) electron fluxes - the injection boundary - was observed in the PS simultaneously with the dipolarization onset and it propagated dawnward along with the onset-related DF. The subsequent dynamics of the energetic electron flux was similar to the dynamics of the magnetic field during the dipolarization. Namely, a gradual linear growth of the electron flux occurred simultaneously with the gradual growth of the BZ field, and it was comprised of multiple short ( ˜ few minutes) electron injections associated with the BZ pulses. This behavior can be explained by the combined action of local betatron acceleration at the BZ pulses and subsequent gradient drifts of electrons in the flux pile up region through the numerous braking and diverting DFs. The nonadiabatic features occasionally observed in the electron spectra during the injections can be due to the electron interactions with high-frequency electromagnetic or electrostatic fluctuations transiently observed in the course of dipolarization. On the contrary, proton injections were detected only in the vicinity of the strongest BZ pulses. The front thickness of these pulses was less than a gyroradius of thermal protons that ensured the nonadiabatic acceleration of protons. Indeed, during the injections in the energy spectra of protons the pronounced bulge was clearly observed in a finite energy range ˜ 70-90 keV. This feature can be explained by the nonadiabatic resonant acceleration of protons by the bursts of the dawn-dusk electric field associated with the BZ pulses.

Magnetosphere dynamics during the 14 November 2012 storm inferred from TWINS, AMPERE, Van Allen Probes, and BATS-R-US-CRCM

NASA Astrophysics Data System (ADS)

Buzulukova, Natalia; Goldstein, Jerry; Fok, Mei-Ching; Glocer, Alex; Valek, Phil; McComas, David; Korth, Haje; Anderson, Brian

2018-01-01

During the 14 November 2012 geomagnetic storm, the Van Allen Probes spacecraft observed a number of sharp decreases (dropouts) in particle fluxes for ions and electrons of different energies. In this paper, we investigate the global magnetosphere dynamics and magnetosphere-ionosphere (M-I) coupling during the dropout events using multipoint measurements by Van Allen Probes, TWINS, and AMPERE together with the output of the two-way coupled global BATS-R-US-CRCM model. We find different behavior for two pairs of dropouts. For one pair, the same pattern was repeated: (1) weak nightside Region 1 and 2 Birkeland currents before and during the dropout; (2) intensification of Region 2 currents after the dropout; and (3) a particle injection detected by TWINS after the dropout. The model predicted similar behavior of Birkeland currents. TWINS low-altitude emissions demonstrated high variability during these intervals, indicating high geomagnetic activity in the near-Earth tail region. For the second pair of dropouts, the structure of both Birkeland currents and ENA emissions was relatively stable. The model also showed quasi-stationary behavior of Birkeland currents and simulated ENA emissions with gradual ring current buildup. We confirm that the first pair of dropouts was caused by large-scale motions of the OCB (open-closed boundary) during substorm activity. We show the new result that this OCB motion was associated with global changes in Birkeland (M-I coupling) currents and strong modulation of low-altitude ion precipitation. The second pair of dropouts is the result of smaller OCB disturbances not related to magnetospheric substorms. The local observations of the first pair of dropouts result from a global magnetospheric reconfiguration, which is manifested by ion injections and enhanced ion precipitation detected by TWINS and changes in the structure of Birkeland currents detected by AMPERE. This study demonstrates that multipoint measurements along with the global model results enable the reconstruction of a more complete system-level picture of the dropout events and provides insight into M-I coupling aspects that have not previously been investigated.

Magnetosphere dynamics during the 14 November 2012 storm inferred from TWINS, AMPERE, Van Allen Probes, and BATS-R-US–CRCM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buzulukova, Natalia; Goldstein, Jerry; Fok, Mei-Ching

During the 14 November 2012 geomagnetic storm, the Van Allen Probes spacecraft observed a number of sharp decreases ("dropouts") in particle fluxes for ions and electrons of different energies. In this paper, we investigate the global magnetosphere dynamics and magnetosphere–ionosphere (M–I) coupling during the dropout events using multipoint measurements by Van Allen Probes, TWINS, and AMPERE together with the output of the two-way coupled global BATS-R-US–CRCM model. We find different behavior for two pairs of dropouts. For one pair, the same pattern was repeated: (1) weak nightside Region 1 and 2 Birkeland currents before and during the dropout; (2) intensificationmore » of Region 2 currents after the dropout; and (3) a particle injection detected by TWINS after the dropout. The model predicted similar behavior of Birkeland currents. TWINS low-altitude emissions demonstrated high variability during these intervals, indicating high geomagnetic activity in the near-Earth tail region. For the second pair of dropouts, the structure of both Birkeland currents and ENA emissions was relatively stable. The model also showed quasi-stationary behavior of Birkeland currents and simulated ENA emissions with gradual ring current buildup. We confirm that the first pair of dropouts was caused by large-scale motions of the OCB (open–closed boundary) during substorm activity. We show the new result that this OCB motion was associated with global changes in Birkeland (M–I coupling) currents and strong modulation of low-altitude ion precipitation. The second pair of dropouts is the result of smaller OCB disturbances not related to magnetospheric substorms. The local observations of the first pair of dropouts result from a global magnetospheric reconfiguration, which is manifested by ion injections and enhanced ion precipitation detected by TWINS and changes in the structure of Birkeland currents detected by AMPERE. This study demonstrates that multipoint measurements along with the global model results enable the reconstruction of a more complete system-level picture of the dropout events and provides insight into M–I coupling aspects that have not previously been investigated.« less

Magnetosphere Dynamics During the 14 November 2012 Storm Inferred from TWINS, AMPERE, Van Allen Probes, and BATS-R-US-CRCM

NASA Technical Reports Server (NTRS)

Buzulukova, Natalia; Goldstein, Jerry; Fok, Mei-Ching; Glocer, Alex; Valek, Phil; McComas, David; Korth, Haje; Anderson, Brian

2018-01-01

During the 14 November 2012 geomagnetic storm, the Van Allen Probes spacecraft observed a number of sharp decreases ('dropouts') in particle fluxes for ions and electrons of different energies. In this paper, we investigate the global magnetosphere dynamics and magnetosphere- ionosphere (M-I) coupling during the dropout events using multipoint measurements by Van Allen Probes, TWINS, and AMPERE together with the output of the two-way coupled global BATS-R-US-CRCM model. We find different behavior for two pairs of dropouts. For one pair, the same pattern was repeated: (1) weak nightside Region 1 and 2 Birkeland currents before and during the dropout; (2) intensification of Region 2 currents after the dropout; and (3) a particle injection detected by TWINS after the dropout. The model predicted similar behavior of Birkeland currents. TWINS low-altitude emissions demonstrated high variability during these intervals, indicating high geomagnetic activity in the near-Earth tail region. For the second pair of dropouts, the structure of both Birkeland currents and ENA emissions was relatively stable. The model also showed quasi-stationary behavior of Birkeland currents and simulated ENA emissions with gradual ring current buildup. We confirm that the first pair of dropouts was caused by large-scale motions of the OCB (open-closed boundary) during substorm activity. We show the new result that this OCB motion was associated with global changes in Birkeland (M-I coupling) currents and strong modulation of low-altitude ion precipitation. The second pair of dropouts is the result of smaller OCB disturbances not related to magnetospheric substorms. The local observations of the first pair of dropouts result from a global magnetospheric reconfiguration, which is manifested by ion injections and enhanced ion precipitation detected by TWINS and changes in the structure of Birkeland currents detected by AMPERE. This study demonstrates that multipoint measurements along with the global model results enable the reconstruction of a more complete system-level picture of the dropout events and provides insight into M-I coupling aspects that have not previously been investigated.

Magnetosphere dynamics during the 14 November 2012 storm inferred from TWINS, AMPERE, Van Allen Probes, and BATS-R-US–CRCM

DOE PAGES

Buzulukova, Natalia; Goldstein, Jerry; Fok, Mei-Ching; ...

2018-01-25

During the 14 November 2012 geomagnetic storm, the Van Allen Probes spacecraft observed a number of sharp decreases ("dropouts") in particle fluxes for ions and electrons of different energies. In this paper, we investigate the global magnetosphere dynamics and magnetosphere–ionosphere (M–I) coupling during the dropout events using multipoint measurements by Van Allen Probes, TWINS, and AMPERE together with the output of the two-way coupled global BATS-R-US–CRCM model. We find different behavior for two pairs of dropouts. For one pair, the same pattern was repeated: (1) weak nightside Region 1 and 2 Birkeland currents before and during the dropout; (2) intensificationmore » of Region 2 currents after the dropout; and (3) a particle injection detected by TWINS after the dropout. The model predicted similar behavior of Birkeland currents. TWINS low-altitude emissions demonstrated high variability during these intervals, indicating high geomagnetic activity in the near-Earth tail region. For the second pair of dropouts, the structure of both Birkeland currents and ENA emissions was relatively stable. The model also showed quasi-stationary behavior of Birkeland currents and simulated ENA emissions with gradual ring current buildup. We confirm that the first pair of dropouts was caused by large-scale motions of the OCB (open–closed boundary) during substorm activity. We show the new result that this OCB motion was associated with global changes in Birkeland (M–I coupling) currents and strong modulation of low-altitude ion precipitation. The second pair of dropouts is the result of smaller OCB disturbances not related to magnetospheric substorms. The local observations of the first pair of dropouts result from a global magnetospheric reconfiguration, which is manifested by ion injections and enhanced ion precipitation detected by TWINS and changes in the structure of Birkeland currents detected by AMPERE. This study demonstrates that multipoint measurements along with the global model results enable the reconstruction of a more complete system-level picture of the dropout events and provides insight into M–I coupling aspects that have not previously been investigated.« less

76 FR 59559 - Facilitating the Use of Microwave for Wireless Backhaul and Other Uses and Providing Additional...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

...] Facilitating the Use of Microwave for Wireless Backhaul and Other Uses and Providing Additional Flexibility To... FS licensees to reduce operational costs, increase reliability, and facilitate the use of wireless... for wireless backhaul and other point-to-point and point-to-multipoint communications. We also make...

Genome-wide and fine-resolution association analysis of malaria in West Africa.

PubMed

Jallow, Muminatou; Teo, Yik Ying; Small, Kerrin S; Rockett, Kirk A; Deloukas, Panos; Clark, Taane G; Kivinen, Katja; Bojang, Kalifa A; Conway, David J; Pinder, Margaret; Sirugo, Giorgio; Sisay-Joof, Fatou; Usen, Stanley; Auburn, Sarah; Bumpstead, Suzannah J; Campino, Susana; Coffey, Alison; Dunham, Andrew; Fry, Andrew E; Green, Angela; Gwilliam, Rhian; Hunt, Sarah E; Inouye, Michael; Jeffreys, Anna E; Mendy, Alieu; Palotie, Aarno; Potter, Simon; Ragoussis, Jiannis; Rogers, Jane; Rowlands, Kate; Somaskantharajah, Elilan; Whittaker, Pamela; Widden, Claire; Donnelly, Peter; Howie, Bryan; Marchini, Jonathan; Morris, Andrew; SanJoaquin, Miguel; Achidi, Eric Akum; Agbenyega, Tsiri; Allen, Angela; Amodu, Olukemi; Corran, Patrick; Djimde, Abdoulaye; Dolo, Amagana; Doumbo, Ogobara K; Drakeley, Chris; Dunstan, Sarah; Evans, Jennifer; Farrar, Jeremy; Fernando, Deepika; Hien, Tran Tinh; Horstmann, Rolf D; Ibrahim, Muntaser; Karunaweera, Nadira; Kokwaro, Gilbert; Koram, Kwadwo A; Lemnge, Martha; Makani, Julie; Marsh, Kevin; Michon, Pascal; Modiano, David; Molyneux, Malcolm E; Mueller, Ivo; Parker, Michael; Peshu, Norbert; Plowe, Christopher V; Puijalon, Odile; Reeder, John; Reyburn, Hugh; Riley, Eleanor M; Sakuntabhai, Anavaj; Singhasivanon, Pratap; Sirima, Sodiomon; Tall, Adama; Taylor, Terrie E; Thera, Mahamadou; Troye-Blomberg, Marita; Williams, Thomas N; Wilson, Michael; Kwiatkowski, Dominic P

2009-06-01

We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found considerable population stratification, and also that signals of association at known malaria resistance loci were greatly attenuated owing to weak linkage disequilibrium (LD). To investigate possible solutions to the problem of low LD, we focused on the HbS locus, sequencing this region of the genome in 62 Gambian individuals and then using these data to conduct multipoint imputation in the GWA samples. This increased the signal of association, from P = 4 × 10(-7) to P = 4 × 10(-14), with the peak of the signal located precisely at the HbS causal variant. Our findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.

Chemical improvement of chitosan-modified beads for the immobilization of Enterococcus faecium DBFIQ E36 L-arabinose isomerase through multipoint covalent attachment approach.

PubMed

Manzo, Ricardo M; de Sousa, Marylane; Fenoglio, Cecilia L; Gonçalves, Luciana Rocha Barro; Mammarella, Enrique J

2015-10-01

D-tagatose is produced from D-galactose by the enzyme L-arabinose isomerase (L-AI) in a commercially viable bioprocess. An active and stable biocatalyst was obtained by modifying chitosan gel structure through reaction with TNBS, D-fructose or DMF, among others. This led to a significant improvement in L-AI immobilization via multipoint covalent attachment approach. Synthetized derivatives were compared with commercial supports such as Eupergit(®) C250L and glyoxal-agarose. The best chitosan derivative for L-AI immobilization was achieved by reacting 4 % (w/v) D-fructose with 3 % (w/v) chitosan at 50 °C for 4 h. When compared to the free enzyme, the glutaraldehyde-activated chitosan biocatalyst showed an apparent activity of 88.4 U g (gel) (-1) with a 211-fold stabilization factor while the glyoxal-agarose biocatalyst gave an apparent activity of 161.8 U g (gel) (-1) with an 85-fold stabilization factor. Hence, chitosan derivatives were comparable to commercial resins, thus becoming a viable low-cost strategy to obtain high active L-AI insolubilized derivatives.

Evaluation of a multi-point method for determining acoustic impedance

NASA Technical Reports Server (NTRS)

Jones, Michael G.; Parrott, Tony L.

1988-01-01

An investigation was conducted to explore potential improvements provided by a Multi-Point Method (MPM) over the Standing Wave Method (SWM) and Two-Microphone Method (TMM) for determining acoustic impedance. A wave propagation model was developed to model the standing wave pattern in an impedance tube. The acoustic impedance of a test specimen was calculated from a best fit of this standing wave pattern to pressure measurements obtained along the impedance tube centerline. Three measurement spacing distributions were examined: uniform, random, and selective. Calculated standing wave patterns match the point pressure measurement distributions with good agreement for a reflection factor magnitude range of 0.004 to 0.999. Comparisons of results using 2, 3, 6, and 18 measurement points showed that the most consistent results are obtained when using at least 6 evenly spaced pressure measurements per half-wavelength. Also, data were acquired with broadband noise added to the discrete frequency noise and impedances were calculated using the MPM and TMM algorithms. The results indicate that the MPM will be superior to the TMM in the presence of significant broadband noise levels associated with mean flow.

A recoding scheme for X-linked and pseudoautosomal loci to be used with computer programs for autosomal LOD-score analysis.

PubMed

Strauch, Konstantin; Baur, Max P; Wienker, Thomas F

2004-01-01

We present a recoding scheme that allows for a parametric multipoint X-chromosomal linkage analysis of dichotomous traits in the context of a computer program for autosomes that can use trait models with imprinting. Furthermore, with this scheme, it is possible to perform a joint multipoint analysis of X-linked and pseudoautosomal loci. It is required that (1) the marker genotypes of all female nonfounders are available and that (2) there are no male nonfounders who have daughters in the pedigree. The second requirement does not apply if the trait locus is pseudoautosomal. The X-linked marker loci are recorded by adding a dummy allele to the males' hemizygous genotypes. For modelling an X-linked trait locus, five different liability classes are defined, in conjunction with a paternal imprinting model for male nonfounders. The formulation aims at the mapping of a diallelic trait locus relative to an arbitrary number of codominant markers with known genetic distances, in cases where a program for a genuine X-chromosomal analysis is not available. 2004 S. Karger AG, Basel.

A Self-Referencing Intensity-Based Fiber Optic Sensor with Multipoint Sensing Characteristics

PubMed Central

Choi, Sang-Jin; Kim, Young-Chon; Song, Minho; Pan, Jae-Kyung

2014-01-01

A self-referencing, intensity-based fiber optic sensor (FOS) is proposed and demonstrated. The theoretical analysis for the proposed design is given, and the validity of the theoretical analysis is confirmed via experiments. We define the measurement parameter, X, and the calibration factor, β, to find the transfer function, Hm,n, of the intensity-based FOS head. The self-referencing and multipoint sensing characteristics of the proposed system are validated by showing the measured Hm,n2 and relative error versus the optical power attenuation of the sensor head for four cases: optical source fluctuation, various remote sensing point distances, fiber Bragg gratings (FBGs) with different characteristics, and multiple sensor heads with cascade and/or parallel forms. The power-budget analysis and limitations of the measurement rates are discussed, and the measurement results of fiber-reinforced plastic (FRP) coupon strain using the proposed FOS are given as an actual measurement. The proposed FOS has several benefits, including a self-referencing characteristic, the flexibility to determine FBGs, and a simple structure in terms of the number of devices and measuring procedure. PMID:25046010

Multipoint study of interplanetary shocks

NASA Astrophysics Data System (ADS)

Blanco-Cano, Xochitl; Kajdic, Primoz; Russell, Christopher T.; Aguilar-Rodriguez, Ernesto; Jian, Lan K.; Luhmann, Janet G.

2016-04-01

Interplanetary (IP) shocks are driven in the heliosphere by Interplanetary Coronal Mass Ejections (ICMEs) and Stream Interaction Regions (SIRs). These shocks perturb the solar wind plasma, and play an active role in the acceleration of ions to suprathermal energies. Shock fronts evolve as they move from the Sun. Their surfaces can be far from uniform and be modulated by changes in the ambient solar wind (magnetic field orientation, flow velocity), shocks rippling, and perturbations upstream and downstream from the shocks, i.e., electromagnetic waves. In this work we use multipoint observations from STEREO, WIND, and MESSENGER missions to study shock characteristics at different helio-longitudes and determine the properties of the waves near them. We also determine shock longitudinal extensions and foreshock sizes. The variations of geometry along the shock surface can result in different extensions of the wave and ion foreshocks ahead of the shocks, and in different wave modes upstream and downtream of the shocks. We find that the ion foreshock can extend up to 0.2 AU ahead of the shock, and that the upstream region with modified solar wind/waves can be very asymmetric.

Multi-point laser coherent detection system and its application on vibration measurement

NASA Astrophysics Data System (ADS)

Fu, Y.; Yang, C.; Xu, Y. J.; Liu, H.; Yan, K.; Guo, M.

2015-05-01

Laser Doppler vibrometry (LDV) is a well-known interferometric technique to measure the motions, vibrations and mode shapes of machine components and structures. The drawback of commercial LDV is that it can only offer a pointwise measurement. In order to build up a vibrometric image, a scanning device is normally adopted to scan the laser point in two spatial axes. These scanning laser Doppler vibrometers (SLDV) assume that the measurement conditions remain invariant while multiple and identical, sequential measurements are performed. This assumption makes SLDVs impractical to do measurement on transient events. In this paper, we introduce a new multiple-point laser coherent detection system based on spatial-encoding technology and fiber configuration. A simultaneous vibration measurement on multiple points is realized using a single photodetector. A prototype16-point laser coherent detection system is built and it is applied to measure the vibration of various objects, such as body of a car or a motorcycle when engine is on and under shock tests. The results show the prospect of multi-point laser coherent detection system in the area of nondestructive test and precise dynamic measurement.

Multipoint Pressure and Temperature Sensing Fiber Optic Cable for Monitoring CO 2 Sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Challener, William

2015-02-10

This report describes the work completed on contract DE-FE0010116. The goal of this two year project was to develop and demonstrate in the laboratory a highly accurate multi-point pressure measurement fiber optic cable based on MEMS pressure sensors suitable for downhole deployment in a CO 2 sequestration well. The sensor interrogator was also to be demonstrated in a remote monitoring system and environmental testing was to be completed to indicate its downhole survivability over a lengthy period of time (e.g., 20 years). An interrogator system based on a pulsed laser excitation was shown to be capable of multiple (potentially 100+)more » simultaneous sensor measurements. Two sensors packages were completed and spliced in a cable onto the same fiber and measured. One sensor package was subsequently measured at high temperatures and pressures in supercritical CO 2, while the other package was measured prior and after being subjected to high torque stresses to mimic downhole deployment. The environmental and stress tests indicated areas in which the package design should be further improved.« less

Parallel multipoint recording of aligned and cultured neurons on micro channel array toward cellular network analysis.

PubMed

Tonomura, Wataru; Moriguchi, Hiroyuki; Jimbo, Yasuhiko; Konishi, Satoshi

2010-08-01

This paper describes an advanced Micro Channel Array (MCA) for recording electrophysiological signals of neuronal networks at multiple points simultaneously. The developed MCA is designed for neuronal network analysis which has been studied by the co-authors using the Micro Electrode Arrays (MEA) system, and employs the principles of extracellular recordings. A prerequisite for extracellular recordings with good signal-to-noise ratio is a tight contact between cells and electrodes. The MCA described herein has the following advantages. The electrodes integrated around individual micro channels are electrically isolated to enable parallel multipoint recording. Reliable clamping of a targeted cell through micro channels is expected to improve the cellular selectivity and the attachment between the cell and the electrode toward steady electrophysiological recordings. We cultured hippocampal neurons on the developed MCA. As a result, the spontaneous and evoked spike potentials could be recorded by sucking and clamping the cells at multiple points. In this paper, we describe the design and fabrication of the MCA and the successful electrophysiological recordings leading to the development of an effective cellular network analysis device.

In vitro evaluation of flow patterns and turbulent kinetic energy in trans-catheter aortic valve prostheses.

PubMed

Giese, Daniel; Weiss, Kilian; Baeßler, Bettina; Madershahian, Navid; Choi, Yeong-Hoon; Maintz, David; Bunck, Alexander C

2018-02-01

The objective of the current work was to evaluate flow and turbulent kinetic energy in different transcatheter aortic valve implants using highly undersampled time-resolved multi-point 3-directional phase-contrast measurements (4D Flow MRI) in an in vitro setup. A pulsatile flow setup was used with a compliant tubing mimicking a stiff left ventricular outflow tract and ascending aorta. Five different implants were measured using a highly undersampled multi-point 4D Flow MRI sequence. Velocities and turbulent kinetic energy values were analysed and compared. Strong variations of turbulent kinetic energy distributions between the valves were observed. Maximum turbulent kinetic energy values ranged from 100 to over 500 J/m 3 while through-plane velocities were similar between all valves. Highly accelerated 4D Flow MRI for the measurement of velocities and turbulent kinetic energy values allowed for the assessment of hemodynamic parameters in five different implant models. The presented setup, measurement protocol and analysis methods provides an efficient approach to compare different valve implants and could aid future novel valve designs.

Observations Regarding Use of Advanced CFD Analysis, Sensitivity Analysis, and Design Codes in MDO

NASA Technical Reports Server (NTRS)

Newman, Perry A.; Hou, Gene J. W.; Taylor, Arthur C., III

1996-01-01

Observations regarding the use of advanced computational fluid dynamics (CFD) analysis, sensitivity analysis (SA), and design codes in gradient-based multidisciplinary design optimization (MDO) reflect our perception of the interactions required of CFD and our experience in recent aerodynamic design optimization studies using CFD. Sample results from these latter studies are summarized for conventional optimization (analysis - SA codes) and simultaneous analysis and design optimization (design code) using both Euler and Navier-Stokes flow approximations. The amount of computational resources required for aerodynamic design using CFD via analysis - SA codes is greater than that required for design codes. Thus, an MDO formulation that utilizes the more efficient design codes where possible is desired. However, in the aerovehicle MDO problem, the various disciplines that are involved have different design points in the flight envelope; therefore, CFD analysis - SA codes are required at the aerodynamic 'off design' points. The suggested MDO formulation is a hybrid multilevel optimization procedure that consists of both multipoint CFD analysis - SA codes and multipoint CFD design codes that perform suboptimizations.

Space Technology 5 Multi-point Measurements of Near-Earth Magnetic Fields: Initial Results

NASA Technical Reports Server (NTRS)

Slavin, James A.; Le, G.; Strangeway, R. L.; Wang, Y.; Boardsen, S.A.; Moldwin, M. B.; Spence, H. E.

2007-01-01

The Space Technology 5 (ST-5) mission successfully placed three micro-satellites in a 300 x 4500 km dawn-dusk orbit on 22 March 2006. Each spacecraft carried a boom-mounted vector fluxgate magnetometer that returned highly sensitive and accurate measurements of the geomagnetic field. These data allow, for the first time, the separation of temporal and spatial variations in field-aligned current (FAC) perturbations measured in low-Earth orbit on time scales of approximately 10 sec to 10 min. The constellation measurements are used to directly determine field-aligned current sheet motion, thickness and current density. In doing so, we demonstrate two multi-point methods for the inference of FAC current density that have not previously been possible in low-Earth orbit; 1) the "standard method," based upon s/c velocity, but corrected for FAC current sheet motion, and 2) the "gradiometer method" which uses simultaneous magnetic field measurements at two points with known separation. Future studies will apply these methods to the entire ST-5 data set and expand to include geomagnetic field gradient analyses as well as field-aligned and ionospheric currents.

Research on atmospheric CO2 remote sensing with open-path tunable diode laser absorption spectroscopy and comparison methods

NASA Astrophysics Data System (ADS)

Xin, Fengxin; Guo, Jinjia; Sun, Jiayun; Li, Jie; Zhao, Chaofang; Liu, Zhishen

2017-06-01

An open-path atmospheric CO2 measurement system was built based on tunable diode laser absorption spectroscopy (TDLAS). The CO2 absorption line near 2 μm was selected, measuring the atmospheric CO2 with direct absorption spectroscopy and carrying on the comparative experiment with multipoint measuring instruments of the open-path. The detection limit of the TDLAS system is 1.94×10-6. The calibration experiment of three AZ-7752 handheld CO2 measuring instruments was carried out with the Los Gatos Research gas analyzer. The consistency of the results was good, and the handheld instrument could be used in the TDLAS system after numerical calibration. With the contrast of three AZ-7752 and their averages, the correlation coefficients are 0.8828, 0.9004, 0.9079, and 0.9393 respectively, which shows that the open-path TDLAS has the best correlation with the average of three AZ-7752 and measures the concentration of atmospheric CO2 accurately. Multipoint measurement provides a convenient comparative method for open-path TDLAS.

Evaluation of Pseudo-Haptic Interactions with Soft Objects in Virtual Environments.

PubMed

Li, Min; Sareh, Sina; Xu, Guanghua; Ridzuan, Maisarah Binti; Luo, Shan; Xie, Jun; Wurdemann, Helge; Althoefer, Kaspar

2016-01-01

This paper proposes a pseudo-haptic feedback method conveying simulated soft surface stiffness information through a visual interface. The method exploits a combination of two feedback techniques, namely visual feedback of soft surface deformation and control of the indenter avatar speed, to convey stiffness information of a simulated surface of a soft object in virtual environments. The proposed method was effective in distinguishing different sizes of virtual hard nodules integrated into the simulated soft bodies. To further improve the interactive experience, the approach was extended creating a multi-point pseudo-haptic feedback system. A comparison with regards to (a) nodule detection sensitivity and (b) elapsed time as performance indicators in hard nodule detection experiments to a tablet computer incorporating vibration feedback was conducted. The multi-point pseudo-haptic interaction is shown to be more time-efficient than the single-point pseudo-haptic interaction. It is noted that multi-point pseudo-haptic feedback performs similarly well when compared to a vibration-based feedback method based on both performance measures elapsed time and nodule detection sensitivity. This proves that the proposed method can be used to convey detailed haptic information for virtual environmental tasks, even subtle ones, using either a computer mouse or a pressure sensitive device as an input device. This pseudo-haptic feedback method provides an opportunity for low-cost simulation of objects with soft surfaces and hard inclusions, as, for example, occurring in ever more realistic video games with increasing emphasis on interaction with the physical environment and minimally invasive surgery in the form of soft tissue organs with embedded cancer nodules. Hence, the method can be used in many low-budget applications where haptic sensation is required, such as surgeon training or video games, either using desktop computers or portable devices, showing reasonably high fidelity in conveying stiffness perception to the user.

Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels.

PubMed

Hellwege, Jacklyn N; Palmer, Nicholette D; Mark Brown, W; Brown, Mark W; Ziegler, Julie T; Sandy An, S; An, Sandy S; Guo, Xiuqing; Ida Chen, Y-D; Chen, Ida Y-D; Taylor, Kent; Hawkins, Gregory A; Ng, Maggie C Y; Speliotes, Elizabeth K; Lorenzo, Carlos; Norris, Jill M; Rotter, Jerome I; Wagenknecht, Lynne E; Langefeld, Carl D; Bowden, Donald W

2015-02-01

We previously identified a low-frequency (1.1 %) coding variant (G45R; rs200573126) in the adiponectin gene (ADIPOQ) which was the basis for a multipoint microsatellite linkage signal (LOD = 8.2) for plasma adiponectin levels in Hispanic families. We have empirically evaluated the ability of data from targeted common variants, exome chip genotyping, and genome-wide association study data to detect linkage and association to adiponectin protein levels at this locus. Simple two-point linkage and association analyses were performed in 88 Hispanic families (1,150 individuals) using 10,958 SNPs on chromosome 3. Approaches were compared for their ability to map the functional variant, G45R, which was strongly linked (two-point LOD = 20.98) and powerfully associated (p value = 8.1 × 10(-50)). Over 450 SNPs within a broad 61 Mb interval around rs200573126 showed nominal evidence of linkage (LOD > 3) but only four other SNPs in this region were associated with p values < 1.0 × 10(-4). When G45R was accounted for, the maximum LOD score across the interval dropped to 4.39 and the best p value was 1.1 × 10(-5). Linked and/or associated variants ranged in frequency (0.0018-0.50) and type (coding, non-coding) and had little detectable linkage disequilibrium with rs200573126 (r (2) < 0.20). In addition, the two-point linkage approach empirically outperformed multipoint microsatellite and multipoint SNP analysis. In the absence of data for rs200573126, family-based linkage analysis using a moderately dense SNP dataset, including both common and low-frequency variants, resulted in stronger evidence for an adiponectin locus than association data alone. Thus, linkage analysis can be a useful tool to facilitate identification of high-impact genetic variants.

A Scalable, Parallel Approach for Multi-Point, High-Fidelity Aerostructural Optimization of Aircraft Configurations

NASA Astrophysics Data System (ADS)

Kenway, Gaetan K. W.

This thesis presents new tools and techniques developed to address the challenging problem of high-fidelity aerostructural optimization with respect to large numbers of design variables. A new mesh-movement scheme is developed that is both computationally efficient and sufficiently robust to accommodate large geometric design changes and aerostructural deformations. A fully coupled Newton-Krylov method is presented that accelerates the convergence of aerostructural systems and provides a 20% performance improvement over the traditional nonlinear block Gauss-Seidel approach and can handle more exible structures. A coupled adjoint method is used that efficiently computes derivatives for a gradient-based optimization algorithm. The implementation uses only machine accurate derivative techniques and is verified to yield fully consistent derivatives by comparing against the complex step method. The fully-coupled large-scale coupled adjoint solution method is shown to have 30% better performance than the segregated approach. The parallel scalability of the coupled adjoint technique is demonstrated on an Euler Computational Fluid Dynamics (CFD) model with more than 80 million state variables coupled to a detailed structural finite-element model of the wing with more than 1 million degrees of freedom. Multi-point high-fidelity aerostructural optimizations of a long-range wide-body, transonic transport aircraft configuration are performed using the developed techniques. The aerostructural analysis employs Euler CFD with a 2 million cell mesh and a structural finite element model with 300 000 DOF. Two design optimization problems are solved: one where takeoff gross weight is minimized, and another where fuel burn is minimized. Each optimization uses a multi-point formulation with 5 cruise conditions and 2 maneuver conditions. The optimization problems have 476 design variables are optimal results are obtained within 36 hours of wall time using 435 processors. The TOGW minimization results in a 4.2% reduction in TOGW with a 6.6% fuel burn reduction, while the fuel burn optimization resulted in a 11.2% fuel burn reduction with no change to the takeoff gross weight.

Effect of age and gender on the number of motor units in healthy subjects estimated by the multipoint incremental MUNE method.

PubMed

Gawel, Malgorzata; Kostera-Pruszczyk, Anna

2014-06-01

Motor unit number estimation (MUNE) is a tool for estimating the number of motor units. The aim was to evaluate the multipoint incremental MUNE method in a healthy population, to analyze whether aging, gender, and the dominant hand side influence the motor unit number, and to assess reproducibility of MUNE with the Shefner modification. We studied 60 volunteers (mean age, 47 ± 17.7 years) in four groups aged 18 to 30, 31 to 45, 46 to 60, and above 60 years. Motor unit number estimation was calculated in the abductor pollicis brevis (APB) and the abductor digiti minimi (ADM) by dividing the single motor unit action potential amplitude into the maximal compound motor action potential amplitude. Test-retest variability was 7%. The mean value of MUNE for APB was 133.2 ± 43 and for ADM was 157.1 ± 39.4. Significant differences in MUNE results were found between groups aged 18 to 30 and 60 years or older and between groups aged 31 to 45 and 60 years or older. Motor unit number estimation results correlated negatively with the age of subjects for both APB and ADM. Single motor unit action potential, reflecting the size of motor unit, increased with the age of subjects only in APB. Compound motor action potential amplitude correlated negatively with the age of subjects in APB and ADM. Significant correlations were seen between MUNE in APB or ADM and compound motor action potential amplitude in these muscles and the age of female subjects. A similar relationship was not found in males. Multipoint incremental MUNE method with the Shefner modification is a noninvasive, easy to perform method with high reproducibility. The loss of motor neurons because of aging could be confirmed by our MUNE study and seems to be more pronounced in females.

Analyzing the Magnetopause Internal Structure: New Possibilities Offered by MMS Tested in a Case Study

NASA Astrophysics Data System (ADS)

Rezeau, L.; Belmont, G.; Manuzzo, R.; Aunai, N.; Dargent, J.

2018-01-01

We explore the structure of the magnetopause using a crossing observed by the Magnetospheric Multiscale (MMS) spacecraft on 16 October 2015. Several methods (minimum variance analysis, BV method, and constant velocity analysis) are first applied to compute the normal to the magnetopause considered as a whole. The different results obtained are not identical, and we show that the whole boundary is not stationary and not planar, so that basic assumptions of these methods are not well satisfied. We then analyze more finely the internal structure for investigating the departures from planarity. Using the basic mathematical definition of what is a one-dimensional physical problem, we introduce a new single spacecraft method, called LNA (local normal analysis) for determining the varying normal, and we compare the results so obtained with those coming from the multispacecraft minimum directional derivative (MDD) tool developed by Shi et al. (2005). This last method gives the dimensionality of the magnetic variations from multipoint measurements and also allows estimating the direction of the local normal when the variations are locally 1-D. This study shows that the magnetopause does include approximate one-dimensional substructures but also two- and three-dimensional structures. It also shows that the dimensionality of the magnetic variations can differ from the variations of other fields so that, at some places, the magnetic field can have a 1-D structure although all the plasma variations do not verify the properties of a global one-dimensional problem. A generalization of the MDD tool is proposed.

Analysing the magnetopause internal structure: new possibilities offered by MMS

NASA Astrophysics Data System (ADS)

Belmont, G.; Rezeau, L.; Manuzzo, R.; Aunai, N.; Dargent, J.

2017-12-01

We explore the structure of the magnetopause using a crossing observed by the MMS spacecraft on October 16th, 2015. Several methods (MVA, BV, CVA) are first applied to compute the normal to the magnetopause considered as a whole. The different results obtained are not identical and we show that the whole boundary is not stationary and not planar, so that basic assumptions of these methods are not well satisfied. We then analyse more finely the internal structure for investigating the departures from planarity. Using the basic mathematical definition of what is a one-dimensional physical problem, we introduce a new method, called LNA (Local Normal Analysis) for determining the varying normal, and we compare the results so obtained with those coming from the MDD tool developed by [Shi et al., 2005]. This method gives the dimensionality of the magnetic variations from multi-point measurements and allows estimating the direction of the local normal using the magnetic field. On the other hand, LNA is a single-spacecraft method which gives the local normal from the magnetic field and particle data. This study shows that the magnetopause does include approximate one-dimensional sub-structures but also two and three dimensional intervals. It also shows that the dimensionality of the magnetic variations can differ from the variations of the other fields so that, at some places, the magnetic field can have a 1D structure although all the plasma variations do not verify the properties of a global one-dimensional problem. Finally a generalisation and a systematic application of the MDD method to the physical quantities of interest is shown.

Gene localization in the Snyder-Robinson syndrome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arena, J.F.; Lubs, H.A.; Schwartz, C.

1994-07-15

A family described as non-specific XLMR by Snyder and Robinson was re-evaluated 23 years later. Clinical and DNA studies were conducted on 17 family members; 6 affected males, 3 carrier females, and 8 normal males. All carrier females were clinically normal and the pattern of inheritance was clearly X-linked. Initial localization studies indicated linkage to the region near the DMD locus in Xp21.22. Further analysis focused on this region using (CA)n repeat polymorphisms for the dystrophin gene and for two markers distal to the gene. The dystrophin markers detected recombination across the entire gene, making it unlikely that the DMDmore » locus was involved in the Snyder-Robinson syndrome. Normal dystrophin staining in a muscle biopsy in one affected male confirmed this observation. Multipoint analysis also indicate that the SRS (Snyder-Robinson Syndrome) locus was distal to DMD, and located near locus DXS41 (lod score = 4.00 at theta = 0.00). The presence of mild to moderate mental retardation, asthenic body build, diminished muscle bulk, nasal speech, high narrow/cleft palate, long thin fingers and great toes and mild to severe scoliosis permitted the delineation of a specific syndrome associated with this previously non-specific disorder. It is important, therefore, to recognize that today`s {open_quotes}non-specific{close_quotes} family may be tomorrow`s syndrome.« less

Link Power Budget and Traffict QoS Performance Analysis of Gygabit Passive Optical Network

NASA Astrophysics Data System (ADS)

Ubaidillah, A.; Alfita, R.; Toyyibah

2018-01-01

Data service of telecommunication network is needed widely in the world; therefore extra wide bandwidth must be provided. For this case, PT. Telekomunikasi Tbk. applies GPON (Gigabit Passive Optical Network) as optical fibre based on telecommunication network system. GPON is a point to a multipoint technology of FTTx (Fiber to The x) that transmits information signals to the subscriber over optical fibre. In GPON trunking system, from OLT (Optical Line Terminal), the network is split to many ONT (Optical Network Terminal) of the subscribers, so it causes path loss and attenuation. In this research, the GPON performance is measured from the link power budget system and the Quality of Service (QoS) of the traffic. And the observation result shows that the link power budget system of this GPON is in good condition. The link power budget values from the mathematical calculation and direct measurement are satisfy the ITU-T G984 Class B standard, that the power level must be between -8 dBm to -27 dBm. While from the traffic performance, the observation result shows that the network resource utility of the subscribers of the observed area is not optimum. The mean of subscriber utility rate is 27.985 bps for upstream and 79.687 bps for downstream. While maximally, It should be 60.800 bps for upstream and 486.400 bps for downstream.

Multi-Point Observations of the Inner Magnetosphere from the Van Allen Probes and Related Missions at NASA's Space Physics Data Facility (SPDF)

NASA Astrophysics Data System (ADS)

McGuire, R. E.; Bilitza, D.; Candey, R. M.; Chimiak, R.; Cooper, J. F.; Garcia, L. N.; Harris, B. T.; Johnson, R. C.; Kovalick, T.; Lal, N.; Leckner, H.; Liu, M.; Papitashvili, N. E.; Roberts, D. A.

2014-12-01

A wide range of current, public, science-quality particle and field data from the Van Allen Probes and related missions is ingested, archived and served to the international science community by SPDF. As an active heliophysics final archive, SPDF now serves 100+ Level-2 and Level-3 data products that fully span the range of measurements from particles and plasmas (RBSPICE, ECT) through magnetic-electric fields and waves (EMFISIS, EFW). This collection of mission data (in a standard CDF format with standard ISTP/SPDF) is available through SPDF's CDAWeb user interface, through CDAWeb's web services and associated APIs for IDL and Matlab users, and through direct FTP/HTTP download access. These data are supplemented with orbit displays through our SSCWeb and 4D Orbit Viewer services and HDP/VSPO direct links to investigator sites/resources. This range of data in CDAWeb makes comparison of data among instruments and spacecraft much easier, as well as comparisons and analysis of these data with current data from other missions including THEMIS, TWINS, Cluster, ACE, Wind and now >120 ground magnetometer stations. In addition, SPDF supports data from the BARREL Antarctic balloon program and new data from instruments on the NOAA GOES and POES spacecraft. SPDF will add public data from the MMS mission to this collection when launched in 2015.

47 CFR 76.1514 - Bundling of video and local exchange services.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 4 2014-10-01 2014-10-01 false Bundling of video and local exchange services... RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Open Video Systems § 76.1514 Bundling of video and local exchange services. An open video system operator may offer video and local exchange...

47 CFR 76.1514 - Bundling of video and local exchange services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 4 2013-10-01 2013-10-01 false Bundling of video and local exchange services... RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Open Video Systems § 76.1514 Bundling of video and local exchange services. An open video system operator may offer video and local exchange...

47 CFR 76.1514 - Bundling of video and local exchange services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false Bundling of video and local exchange services... RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Open Video Systems § 76.1514 Bundling of video and local exchange services. An open video system operator may offer video and local exchange...

47 CFR 76.1514 - Bundling of video and local exchange services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Bundling of video and local exchange services... RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Open Video Systems § 76.1514 Bundling of video and local exchange services. An open video system operator may offer video and local exchange...

47 CFR 76.1514 - Bundling of video and local exchange services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 4 2011-10-01 2011-10-01 false Bundling of video and local exchange services... RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Open Video Systems § 76.1514 Bundling of video and local exchange services. An open video system operator may offer video and local exchange...

Intraportal islet transplantation: the impact of the liver microenvironment.

PubMed

Delaune, Vaihere; Berney, Thierry; Lacotte, Stéphanie; Toso, Christian

2017-03-01

The portal vein remains the preferred site for pancreatic islet transplantation due to its easy access and low morbidity. However, despite great progress in isolation and transplantation protocols over the past few years, it is still associated with the early loss of some 50-70% of transplanted islets. The complex liver microenvironment itself presumably plays an important role in this loss. The present review focuses on the specifics of the liver microenvironment, notably the localized hepatic ischemia/reperfusion injury following transplantation, the low oxygenation of the portal vein, the instant blood-mediated inflammatory reaction, the endogenous liver immune system, and the gut-liver axis, and how they can each have an impact on the transplanted islets. It identifies the potential, or already applied, clinical interventions for improving intraportal islet survival, and pinpoints those promising areas still lacking preclinical research. Future interventions on clinical intraportal islet transplantation need to take into account the global context of the liver microenvironment, with multi-point interventions being most likely to improve early islet survival and engraftment. © 2017 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT.

Laser-induced breakdown ignition in a gas fed two-stroke engine

NASA Astrophysics Data System (ADS)

Loktionov, E. Y.; Pasechnikov, N. A.; Telekh, V. D.

2018-01-01

Laser-induced ignition for internal combustion engines is investigated intensively after demonstration of a compact ‘laser plug’ possibility. Laser spark benefits as compared to traditional spark plugs are higher compression rate, and possibility of almost any fuel ignition, so lean mixtures burning with lower temperatures could reduce harmful exhausts (NO x , CH, etc). No need in electrode and possibility for multi-point, linear or circular ignition can make combustion even more effective. Laser induced combustion wave appears faster and is more stable in time, than electric one, so can be used for ramjets, chemical thrusters, and gas turbines. To the best of our knowledge, we have performed laser spark ignition of a gas fed two-stroke engine for the first time. Combustion temperature and pressure, exhaust composition, ignition timing were investigated at laser and compared to a regular electric spark ignition in a two-stroke model engine. Presented results show possibility for improvement of two-stroke engines performance, in terms of rotation rate increase and NO x emission reduction. Such compact engines using locally mined fuel could be highly demanded in remote Arctic areas.

Nance-Horan syndrome: localization within the region Xp21.1-Xp22.3 by linkage analysis.

PubMed

Stambolian, D; Lewis, R A; Buetow, K; Bond, A; Nussbaum, R

1990-07-01

Nance-Horan Syndrome (NHS) or X-linked cataract-dental syndrome (MIM 302350) is a disease of unknown pathogenesis characterized by congenital cataracts and dental anomalies. We performed linkage analysis in three kindreds with NHS by using six RFLP markers between Xp11.3 and Xp22.3. Close linkage was found between NHS and polymorphic loci DXS43 (theta = 0 with lod score 2.89), DXS41 (theta = 0 with lod score 3.44), and DXS67 (theta = 0 with lod score 2.74), defined by probes pD2, p99-6, and pB24, respectively. Recombinations were found with the marker loci DXS84 (theta = .04 with lod score 4.13), DXS143 (theta = .06 with lod score 3.11) and DXS7 (theta = .09 with lod score 1.68). Multipoint linkage analysis determined the NHS locus to be linked completely to DXS41 (lod score = 7.07). Our linkage results, combined with analysis of Xp interstitial deletions, suggest that the NHS locus is located within or close to the Xp22.1-Xp22.2 region.

Nance-Horan syndrome: localization within the region Xp21.1-Xp22.3 by linkage analysis.

PubMed Central

Stambolian, D; Lewis, R A; Buetow, K; Bond, A; Nussbaum, R

1990-01-01

Nance-Horan Syndrome (NHS) or X-linked cataract-dental syndrome (MIM 302350) is a disease of unknown pathogenesis characterized by congenital cataracts and dental anomalies. We performed linkage analysis in three kindreds with NHS by using six RFLP markers between Xp11.3 and Xp22.3. Close linkage was found between NHS and polymorphic loci DXS43 (theta = 0 with lod score 2.89), DXS41 (theta = 0 with lod score 3.44), and DXS67 (theta = 0 with lod score 2.74), defined by probes pD2, p99-6, and pB24, respectively. Recombinations were found with the marker loci DXS84 (theta = .04 with lod score 4.13), DXS143 (theta = .06 with lod score 3.11) and DXS7 (theta = .09 with lod score 1.68). Multipoint linkage analysis determined the NHS locus to be linked completely to DXS41 (lod score = 7.07). Our linkage results, combined with analysis of Xp interstitial deletions, suggest that the NHS locus is located within or close to the Xp22.1-Xp22.2 region. PMID:1971992

A novel optical fiber displacement sensor of wider measurement range based on neural network

NASA Astrophysics Data System (ADS)

Guo, Yuan; Dai, Xue Feng; Wang, Yu Tian

2006-02-01

By studying on the output characteristics of random type optical fiber sensor and semicircular type optical fiber sensor, the ratio of the two output signals was used as the output signal of the whole system. Then the measurement range was enlarged, the linearity was improved, and the errors of reflective and absorbent changing of target surface are automatically compensated. Meantime, an optical fiber sensor model of correcting static error based on BP artificial neural network(ANN) is set up. So the intrinsic errors such as effects of fluctuations in the light, circuit excursion, the intensity losses in the fiber lines and the additional losses in the receiving fiber caused by bends are eliminated. By discussing in theory and experiment, the error of nonlinear is 2.9%, the measuring range reaches to 5-6mm and the relative accuracy is 2%.And this sensor has such characteristics as no electromagnetic interference, simple construction, high sensitivity, good accuracy and stability. Also the multi-point sensor system can be used to on-line and non-touch monitor in working locales.

Combined virtual and real robotic test-bed for single operator control of multiple robots

NASA Astrophysics Data System (ADS)

Lee, Sam Y.-S.; Hunt, Shawn; Cao, Alex; Pandya, Abhilash

2010-04-01

Teams of heterogeneous robots with different dynamics or capabilities could perform a variety of tasks such as multipoint surveillance, cooperative transport and explorations in hazardous environments. In this study, we work with heterogeneous robots of semi-autonomous ground and aerial robots for contaminant localization. We developed a human interface system which linked every real robot to its virtual counterpart. A novel virtual interface has been integrated with Augmented Reality that can monitor the position and sensory information from video feed of ground and aerial robots in the 3D virtual environment, and improve user situational awareness. An operator can efficiently control the real multi-robots using the Drag-to-Move method on the virtual multi-robots. This enables an operator to control groups of heterogeneous robots in a collaborative way for allowing more contaminant sources to be pursued simultaneously. The advanced feature of the virtual interface system is guarded teleoperation. This can be used to prevent operators from accidently driving multiple robots into walls and other objects. Moreover, the feature of the image guidance and tracking is able to reduce operator workload.

Atmospheric Teleconnections From Cumulants

NASA Astrophysics Data System (ADS)

Sabou, F.; Kaspi, Y.; Marston, B.; Schneider, T.

2011-12-01

Multi-point cumulants of fields such as vorticity provide a way to visualize atmospheric teleconnections, complementing other approaches such as the method of empirical orthogonal functions (EOFs). We calculate equal-time two-point cumulants of the vorticity from NCEP reanalysis data during the period 1980 -- 2010 and from direct numerical simulation (DNS) using an idealized dry general circulation model (GCM) (Schneider and Walker, 2006). Extratropical correlations seen in the NCEP data are qualitatively reproduced by the model. Three- and four-point cumulants accumulated from DNS quantify departures of the probability distribution function from a normal distribution, shedding light on the efficacy of direct statistical simulation (DSS) of atmosphere dynamics by cumulant expansions (Marston, Conover, and Schneider, 2008; Marston 2011). Lagged-time two-point cumulants between temperature gradients and eddy kinetic energy (EKE), accumulated by DNS of an idealized moist aquaplanet GCM (O'Gorman and Schneider, 2008), reveal dynamics of storm tracks. Regions of enhanced baroclinicity (as found along the eastern boundary of continents) lead to a local enhancement of EKE and a suppression of EKE further downstream as the storm track self-destructs (Kaspi and Schneider, 2011).

Utah's Regional/Urban ANSS Seismic Network---Strategies and Tools for Quality Performance

NASA Astrophysics Data System (ADS)

Burlacu, R.; Arabasz, W. J.; Pankow, K. L.; Pechmann, J. C.; Drobeck, D. L.; Moeinvaziri, A.; Roberson, P. M.; Rusho, J. A.

2007-05-01

The University of Utah's regional/urban seismic network (224 stations recorded: 39 broadband, 87 strong-motion, 98 short-period) has become a model for locally implementing the Advanced National Seismic System (ANSS) because of successes in integrating weak- and strong-motion recording and in developing an effective real-time earthquake information system. Early achievements included implementing ShakeMap, ShakeCast, point-to- multipoint digital telemetry, and an Earthworm Oracle database, as well as in-situ calibration of all broadband and strong-motion stations and submission of all data and metadata into the IRIS DMC. Regarding quality performance, our experience as a medium-size regional network affirms the fundamental importance of basics such as the following: for data acquisition, deliberate attention to high-quality field installations, signal quality, and computer operations; for operational efficiency, a consistent focus on professional project management and human resources; and for customer service, healthy partnerships---including constant interactions with emergency managers, engineers, public policy-makers, and other stakeholders as part of an effective state earthquake program. (Operational cost efficiencies almost invariably involve trade-offs between personnel costs and the quality of hardware and software.) Software tools that we currently rely on for quality performance include those developed by UUSS (e.g., SAC and shell scripts for estimating local magnitudes) and software developed by other organizations such as: USGS (Earthworm), University of Washington (interactive analysis software), ISTI (SeisNetWatch), and IRIS (PDCC, BUD tools). Although there are many pieces, there is little integration. One of the main challenges we face is the availability of a complete and coherent set of tools for automatic and post-processing to assist in achieving the goals/requirements set forth by ANSS. Taking our own network---and ANSS---to the next level will require standardized, well-designed, and supported software. Other advances in seismic network performance will come from diversified instrumentation. We have recently shown the utility of incorporating strong-motion data (even from soil sites) into the routine analysis of local seismicity, and have also collocated an acoustic array with a broadband seismic station (in collaboration with Southern Methodist University). For the latter experiment, the purpose of collocated seismic and infrasound sensors is to (1) further an understanding of the physics associated with the generation and the propagation of seismic and low-frequency acoustic energy from shallow sources and (2) explore the potential for blast discrimination and improved source location using seismic and infrasonic data in a synergetic way.

Connecting Land-Based Networks to Ships

DTIC Science & Technology

2013-06-01

multipoint wireless broadband systems, and WiMAX networks were initially deployed for fixed and nomadic (portable) applications. These standards...CAPABILITIES OF SHIP-TO-SHORE COMMUNICATIONS A. US Navy Automated Digital Network System (ADNS) The U.S. Navy’s Automated Digital Network System (ADNS...submit digitally any necessary documents to the terminal operators, contact their logistics providers, access tidal information and receive

Antibacterial activity of four mouthrinses containing triclosan against salivary Staphylococcus aureus

PubMed Central

Tanomaru, Juliane Maria Guerreiro; Nascimento, Andresa Piacezzi; Watanabe, Evandro; Matoba-Júnior, Fumio; Tanomaru-Filho, Mário; Ito, Izabel Yoko

2008-01-01

The maximum inhibitory dilution (MID) of triclosan-based mouthwashes against 28 Staphylococcus aureus strains was evaluated. Dilutions ranging from 1/10 to 1/655,360 were prepared. Strains were inoculated using a Steers multipoint inoculator. The MID was considered as the maximum dilution capable of inhibiting microorganism growth. The mouthwashes presented different MIDs. PMID:24031267

Antibacterial activity of four mouthrinses containing triclosan against salivary Staphylococcus aureus.

PubMed

Tanomaru, Juliane Maria Guerreiro; Nascimento, Andresa Piacezzi; Watanabe, Evandro; Matoba-Júnior, Fumio; Tanomaru-Filho, Mário; Ito, Izabel Yoko

2008-07-01

The maximum inhibitory dilution (MID) of triclosan-based mouthwashes against 28 Staphylococcus aureus strains was evaluated. Dilutions ranging from 1/10 to 1/655,360 were prepared. Strains were inoculated using a Steers multipoint inoculator. The MID was considered as the maximum dilution capable of inhibiting microorganism growth. The mouthwashes presented different MIDs.

Perturbative Yang-Mills theory without Faddeev-Popov ghost fields

NASA Astrophysics Data System (ADS)

Huffel, Helmuth; Markovic, Danijel

2018-05-01

A modified Faddeev-Popov path integral density for the quantization of Yang-Mills theory in the Feynman gauge is discussed, where contributions of the Faddeev-Popov ghost fields are replaced by multi-point gauge field interactions. An explicit calculation to O (g2) shows the equivalence of the usual Faddeev-Popov scheme and its modified version.

75 FR 26743 - Pacific Gas and Electric Company; Notice of Environmental Site Review and Technical Meetings To...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

... Ocean, 2.5 to 3.0 nautical miles west of Manila on Samoa Peninsula of Humboldt Bay, near Eureka... Conversion devises (WEC), including multi-point catenary moorings and anchors; (2) marker buoys, navigation... interconnection to the electrical grid; and (6) appurtenant facilities. WEC types that may be installed may...

Item Estimates under Low-Stakes Conditions: How Should Omits Be Treated?

ERIC Educational Resources Information Center

DeMars, Christine

Using data from a pilot test of science and math from students in 30 high schools, item difficulties were estimated with a one-parameter model (partial-credit model for the multi-point items). Some items were multiple-choice items, and others were constructed-response items (open-ended). Four sets of estimates were obtained: estimates for males…

Exclusionary policies in urban development: Under-servicing migrant households in Brazilian cities

PubMed Central

Feler, Leo; Henderson, J. Vernon

2012-01-01

Localities in developed countries often enact regulations to deter low-income households from moving in. In developing countries, such restrictions lead to the emergence of informal housing sectors. To deter low-income migrants, localities in developing countries withhold public services to the informal housing sector. Using a large sample of Brazilian localities, we examine migration and exclusion, focusing on the public provision of water to small houses where low-income migrants are likely to live. Withholding water connections reduces the locality growth rate, particularly of low-education households. In terms of service provision, during dictatorship in Brazil, we find evidence of strategic exclusion, where localities appear to withhold services to deter in-migration. We also find evidence of strategic interactions among localities within metro areas in their setting of service levels: if one locality provides more services to migrant households, other localities respond by withholding service. PMID:22707807

Travel for HIV care in England: a choice or a necessity?

PubMed

Huntington, S; Chadborn, T; Rice, B D; Brown, A E; Delpech, V C

2011-07-01

The aims of the study were (1) to measure the distance required to travel, and the distance actually travelled, to HIV services by HIV-infected adults, and (2) to calculate the proportion of patients who travelled beyond local services and identify socio-demographic and clinical predictors of use of non-local services. The straight-line distance between a patient's residence and HIV services was determined for HIV-infected patients in England in 2007. 'Local services' were defined as the closest HIV service to a patient's residence and other services within an additional 5 km radius. Multivariable logistic regression was used to identify socio-demographic and clinical predictors of accessing non-local services. In 2007, nearly 57 000 adults with diagnosed HIV infection accessed HIV services in England; 42% lived in the most deprived areas. Overall, 81% of patients lived within 5 km of a service, and 8.7% used their closest HIV service. The median distance to the closest HIV service was 2.5 km [interquartile range (IQR) 1.5-4.2 km] and the median actual distance travelled was 4.8 km (IQR 2.5-9.7 km). A quarter of patients used a 'non-local' service. Patients living in the least deprived areas were twice as likely to use non-local services as those living in the most deprived areas [adjusted odds ratio (AOR) 2.16; 95% confidence interval (CI) 1.98-2.37]. Other predictors for accessing non-local services included living in an urban area (AOR 0.77; 95% CI 0.69-0.85) and being diagnosed more than 12 months (AOR 1.48; 95% CI 1.38-1.59). In England, 81% of HIV-infected patients live within 5 km of HIV services and a quarter of HIV-infected adults travel to non-local HIV services. Those living in deprived areas are less likely to travel to non-local services. © 2010 British HIV Association.

Turbulent scaling laws as solutions of the multi-point correlation equation using statistical symmetries

NASA Astrophysics Data System (ADS)

Oberlack, Martin; Rosteck, Andreas; Avsarkisov, Victor

2013-11-01

Text-book knowledge proclaims that Lie symmetries such as Galilean transformation lie at the heart of fluid dynamics. These important properties also carry over to the statistical description of turbulence, i.e. to the Reynolds stress transport equations and its generalization, the multi-point correlation equations (MPCE). Interesting enough, the MPCE admit a much larger set of symmetries, in fact infinite dimensional, subsequently named statistical symmetries. Most important, theses new symmetries have important consequences for our understanding of turbulent scaling laws. The symmetries form the essential foundation to construct exact solutions to the infinite set of MPCE, which in turn are identified as classical and new turbulent scaling laws. Examples on various classical and new shear flow scaling laws including higher order moments will be presented. Even new scaling have been forecasted from these symmetries and in turn validated by DNS. Turbulence modellers have implicitly recognized at least one of the statistical symmetries as this is the basis for the usual log-law which has been employed for calibrating essentially all engineering turbulence models. An obvious conclusion is to generally make turbulence models consistent with the new statistical symmetries.

Model-Based Linkage Analysis of a Quantitative Trait.

PubMed

Song, Yeunjoo E; Song, Sunah; Schnell, Audrey H

2017-01-01

Linkage Analysis is a family-based method of analysis to examine whether any typed genetic markers cosegregate with a given trait, in this case a quantitative trait. If linkage exists, this is taken as evidence in support of a genetic basis for the trait. Historically, linkage analysis was performed using a binary disease trait, but has been extended to include quantitative disease measures. Quantitative traits are desirable as they provide more information than binary traits. Linkage analysis can be performed using single-marker methods (one marker at a time) or multipoint (using multiple markers simultaneously). In model-based linkage analysis the genetic model for the trait of interest is specified. There are many software options for performing linkage analysis. Here, we use the program package Statistical Analysis for Genetic Epidemiology (S.A.G.E.). S.A.G.E. was chosen because it also includes programs to perform data cleaning procedures and to generate and test genetic models for a quantitative trait, in addition to performing linkage analysis. We demonstrate in detail the process of running the program LODLINK to perform single-marker analysis, and MLOD to perform multipoint analysis using output from SEGREG, where SEGREG was used to determine the best fitting statistical model for the trait.

Intercontinental Multi-Domain Monitoring for LHC with perfSONAR

NASA Astrophysics Data System (ADS)

Vicinanza, D.

2012-12-01

The Large Hadron Collider (LHC) is currently running at CERN in Geneva, Switzerland. Physicists are using LHC to recreate the conditions just after the Big Bang, by colliding two beams of particles and heavy ions head-on at very high energy. The project is generating more than 15 TB of raw data per year, plus 10 TB of “event summary data”. This data is sent out from CERN to eleven Tier 1 research centres in Europe, Asia, and North America using a multi-gigabits Optical Private Network (OPN), the LHCOPN. Tier 1 sites are then connected to 100+ academic and research institutions in the world (the Tier 2s) through a Multipoint to Multipoint network, the LHC Open Network Environment (LHCONE). Network monitoring on such complex network architecture to ensure robust and reliable operation is of crucial importance. The chosen approach for monitoring the OPN and ONE is based on the perfSONAR framework, which is designed for multi-domain monitoring environments. perfSONAR (www.perfsonar.net) is an infrastructure for performance monitoring data exchange between networks, making it easier to solve performance problems occurring between network measurement points interconnected through several network domains.

Developing a multipoint titration method with a variable dose implementation for anaerobic digestion monitoring.

PubMed

Salonen, K; Leisola, M; Eerikäinen, T

2009-01-01

Determination of metabolites from an anaerobic digester with an acid base titration is considered as superior method for many reasons. This paper describes a practical at line compatible multipoint titration method. The titration procedure was improved by speed and data quality. A simple and novel control algorithm for estimating a variable titrant dose was derived for this purpose. This non-linear PI-controller like algorithm does not require any preliminary information from sample. Performance of this controller is superior compared to traditional linear PI-controllers. In addition, simplification for presenting polyprotic acids as a sum of multiple monoprotic acids is introduced along with a mathematical error examination. A method for inclusion of the ionic strength effect with stepwise iteration is shown. The titration model is presented with matrix notations enabling simple computation of all concentration estimates. All methods and algorithms are illustrated in the experimental part. A linear correlation better than 0.999 was obtained for both acetate and phosphate used as model compounds with slopes of 0.98 and 1.00 and average standard deviations of 0.6% and 0.8%, respectively. Furthermore, insensitivity of the presented method for overlapping buffer capacity curves was shown.

Hydrolysis of tannic acid catalyzed by immobilized-stabilized derivatives of Tannase from Lactobacillus plantarum.

PubMed

Curiel, Jose Antonio; Betancor, Lorena; de las Rivas, Blanca; Muñoz, Rosario; Guisan, Jose M; Fernández-Lorente, Gloria

2010-05-26

A recombinant tannase from Lactobacillus plantarum , overexpressed in Escherichia coli , was purified in a single step by metal chelate affinity chromatography on poorly activated nickel supports. It was possible to obtain 0.9 g of a pure enzyme by using only 20 mL of chromatographic support. The pure enzyme was immobilized and stabilized by multipoint covalent immobilization on highly activated glyoxyl agarose. Derivatives obtained by multipoint and multisubunit immobilization were 500- and 1000-fold more stable than both the soluble enzyme and the one-point-immobilized enzyme in experiments of thermal and cosolvent inactivation, respectively. In addition, up to 70 mg of pure enzyme was immobilized on 1 g of wet support. The hydrolysis of tannic acid was optimized by using the new immobilized tannase derivative. The optimal reaction conditions were 30% diglyme at pH 5.0 and 4 degrees C. Under these conditions, it was possible to obtain 47.5 mM gallic acid from 5 mM tannic acid as substrate. The product was pure as proved by HPLC. On the other hand, the immobilized biocatalyst preserved >95% of its initial activity after 1 month of incubation under the optimal reaction conditions.

Development of a Multi-Point Microwave Interferometry (MPMI) Method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Specht, Paul Elliott; Cooper, Marcia A.; Jilek, Brook Anton

2015-09-01

A multi-point microwave interferometer (MPMI) concept was developed for non-invasively tracking a shock, reaction, or detonation front in energetic media. Initially, a single-point, heterodyne microwave interferometry capability was established. The design, construction, and verification of the single-point interferometer provided a knowledge base for the creation of the MPMI concept. The MPMI concept uses an electro-optic (EO) crystal to impart a time-varying phase lag onto a laser at the microwave frequency. Polarization optics converts this phase lag into an amplitude modulation, which is analyzed in a heterodyne interfer- ometer to detect Doppler shifts in the microwave frequency. A version of themore » MPMI was constructed to experimentally measure the frequency of a microwave source through the EO modulation of a laser. The successful extraction of the microwave frequency proved the underlying physical concept of the MPMI design, and highlighted the challenges associated with the longer microwave wavelength. The frequency measurements made with the current equipment contained too much uncertainty for an accurate velocity measurement. Potential alterations to the current construction are presented to improve the quality of the measured signal and enable multiple accurate velocity measurements.« less

A Novel Form of “Central Pouchlike” Cataract, with Sutural Opacities, Maps to Chromosome 15q21-22

PubMed Central

Vanita; Singh, Jai Rup; Sarhadi, Virinder K.; Singh, Daljit; Reis, André; Rueschendorf, Franz; Becker-Follmann, Johannes; Jung, Martin; Sperling, Karl

2001-01-01

Congenital cataract is a clinically and genetically highly heterogeneous eye disorder, with autosomal dominant inheritance being most common. We investigated a large seven-generation family with 74 individuals affected by autosomal dominant congenital cataract (ADCC). The phenotype in this family can be described as “central pouchlike” cataract with sutural opacities, and it differs from the other mapped cataracts. We performed linkage analysis with microsatellite markers in this family and excluded the known candidate genes. A genomewide search revealed linkage to markers on chromosome 15, with a maximum two-point LOD score of 5.98 at θ=0 with marker D15S117. Multipoint analysis also gave a maximum LOD score of 5.98 at D15S117. Multipoint and haplotype analysis narrowed the cataract locus to a 10-cM region between markers D15S209 and D15S1036, closely linked to marker D15S117 in q21-q22 region of chromosome 15. This is the first report of a gene for a clinically new type of ADCC at 15q21-22 locus. PMID:11133359

An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range.

PubMed

Anazawa, Takashi; Yamazaki, Motohiro

2017-12-05

Although multi-point, multi-color fluorescence-detection systems are widely used in various sciences, they would find wider applications if they are miniaturized. Accordingly, an ultra-small, four-emission-point and four-color fluorescence-detection system was developed. Its size (space between emission points and a detection plane) is 15 × 10 × 12 mm, which is three-orders-of-magnitude smaller than that of a conventional system. Fluorescence from four emission points with an interval of 1 mm on the same plane was respectively collimated by four lenses and split into four color fluxes by four dichroic mirrors. Then, a total of sixteen parallel color fluxes were directly input into an image sensor and simultaneously detected. The emission-point plane and the detection plane (the image-sensor surface) were parallel and separated by a distance of only 12 mm. The developed system was applied to four-capillary array electrophoresis and successfully achieved Sanger DNA sequencing. Moreover, compared with a conventional system, the developed system had equivalent high fluorescence-detection sensitivity (lower detection limit of 17 pM dROX) and 1.6-orders-of-magnitude higher dynamic range (4.3 orders of magnitude).

New method for determining central axial orientation of flux rope embedded within current sheet using multipoint measurements

NASA Astrophysics Data System (ADS)

Li, ZhaoYu; Chen, Tao; Yan, GuangQing

2016-10-01

A new method for determining the central axial orientation of a two-dimensional coherent magnetic flux rope (MFR) via multipoint analysis of the magnetic-field structure is developed. The method is devised under the following geometrical assumptions: (1) on its cross section, the structure is left-right symmetric; (2) the projected structure velocity is vertical to the line of symmetry. The two conditions can be naturally satisfied for cylindrical MFRs and are expected to be satisfied for MFRs that are flattened within current sheets. The model test demonstrates that, for determining the axial orientation of such structures, the new method is more efficient and reliable than traditional techniques such as minimum-variance analysis of the magnetic field, Grad-Shafranov (GS) reconstruction, and the more recent method based on the cylindrically symmetric assumption. A total of five flux transfer events observed by Cluster are studied using the proposed approach, and the application results indicate that the observed structures, regardless of their actual physical properties, fit the assumed geometrical model well. For these events, the inferred axial orientations are all in excellent agreement with those obtained using the multi-GS reconstruction technique.

Remote information service access system based on a client-server-service model

DOEpatents

Konrad, Allan M.

1996-01-01

A local host computing system, a remote host computing system as connected by a network, and service functionalities: a human interface service functionality, a starter service functionality, and a desired utility service functionality, and a Client-Server-Service (CSS) model is imposed on each service functionality. In one embodiment, this results in nine logical components and three physical components (a local host, a remote host, and an intervening network), where two of the logical components are integrated into one Remote Object Client component, and that Remote Object Client component and the other seven logical components are deployed among the local host and remote host in a manner which eases compatibility and upgrade problems, and provides an illusion to a user that a desired utility service supported on a remote host resides locally on the user's local host, thereby providing ease of use and minimal software maintenance for users of that remote service.

Remote information service access system based on a client-server-service model

DOEpatents

Konrad, A.M.

1997-12-09

A local host computing system, a remote host computing system as connected by a network, and service functionalities: a human interface service functionality, a starter service functionality, and a desired utility service functionality, and a Client-Server-Service (CSS) model is imposed on each service functionality. In one embodiment, this results in nine logical components and three physical components (a local host, a remote host, and an intervening network), where two of the logical components are integrated into one Remote Object Client component, and that Remote Object Client component and the other seven logical components are deployed among the local host and remote host in a manner which eases compatibility and upgrade problems, and provides an illusion to a user that a desired utility service supported on a remote host resides locally on the user`s local host, thereby providing ease of use and minimal software maintenance for users of that remote service. 16 figs.

Remote information service access system based on a client-server-service model

DOEpatents

Konrad, Allan M.

1999-01-01

A local host computing system, a remote host computing system as connected by a network, and service functionalities: a human interface service functionality, a starter service functionality, and a desired utility service functionality, and a Client-Server-Service (CSS) model is imposed on each service functionality. In one embodiment, this results in nine logical components and three physical components (a local host, a remote host, and an intervening network), where two of the logical components are integrated into one Remote Object Client component, and that Remote Object Client component and the other seven logical components are deployed among the local host and remote host in a manner which eases compatibility and upgrade problems, and provides an illusion to a user that a desired utility service supported on a remote host resides locally on the user's local host, thereby providing ease of use and minimal software maintenance for users of that remote service.

Remote information service access system based on a client-server-service model

DOEpatents

Konrad, A.M.

1996-08-06

A local host computing system, a remote host computing system as connected by a network, and service functionalities: a human interface service functionality, a starter service functionality, and a desired utility service functionality, and a Client-Server-Service (CSS) model is imposed on each service functionality. In one embodiment, this results in nine logical components and three physical components (a local host, a remote host, and an intervening network), where two of the logical components are integrated into one Remote Object Client component, and that Remote Object Client component and the other seven logical components are deployed among the local host and remote host in a manner which eases compatibility and upgrade problems, and provides an illusion to a user that a desired utility service supported on a remote host resides locally on the user`s local host, thereby providing ease of use and minimal software maintenance for users of that remote service. 16 figs.

Remote information service access system based on a client-server-service model

DOEpatents

Konrad, Allan M.

1997-01-01

A local host computing system, a remote host computing system as connected by a network, and service functionalities: a human interface service functionality, a starter service functionality, and a desired utility service functionality, and a Client-Server-Service (CSS) model is imposed on each service functionality. In one embodiment, this results in nine logical components and three physical components (a local host, a remote host, and an intervening network), where two of the logical components are integrated into one Remote Object Client component, and that Remote Object Client component and the other seven logical components are deployed among the local host and remote host in a manner which eases compatibility and upgrade problems, and provides an illusion to a user that a desired utility service supported on a remote host resides locally on the user's local host, thereby providing ease of use and minimal software maintenance for users of that remote service.

29 CFR 779.315 - Traditional local retail or service establishments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 3 2012-07-01 2012-07-01 false Traditional local retail or service establishments. 779.315... STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments Making Sales of Goods and Services ârecognized As Retailâ § 779.315 Traditional local retail or...

29 CFR 779.315 - Traditional local retail or service establishments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 3 2014-07-01 2014-07-01 false Traditional local retail or service establishments. 779.315... STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments Making Sales of Goods and Services ârecognized As Retailâ § 779.315 Traditional local retail or...

29 CFR 779.315 - Traditional local retail or service establishments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Traditional local retail or service establishments. 779.315... STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments Making Sales of Goods and Services ârecognized As Retailâ § 779.315 Traditional local retail or...

29 CFR 779.315 - Traditional local retail or service establishments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 3 2011-07-01 2011-07-01 false Traditional local retail or service establishments. 779.315... STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments Making Sales of Goods and Services ârecognized As Retailâ § 779.315 Traditional local retail or...

29 CFR 779.315 - Traditional local retail or service establishments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 3 2013-07-01 2013-07-01 false Traditional local retail or service establishments. 779.315... STANDARDS ACT AS APPLIED TO RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments Making Sales of Goods and Services ârecognized As Retailâ § 779.315 Traditional local retail or...

39 CFR 447.52 - Holding of State or local office by Postal Service employees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Holding of State or local office by Postal Service employees. 447.52 Section 447.52 Postal Service UNITED STATES POSTAL SERVICE PERSONNEL RULES OF CONDUCT FOR POSTAL EMPLOYEES Participation in Community Affairs § 447.52 Holding of State or local office by Postal Service employees. (a) An employee...

Preparing WIND for the STEREO Mission

NASA Astrophysics Data System (ADS)

Schroeder, P.; Ogilve, K.; Szabo, A.; Lin, R.; Luhmann, J.

2006-05-01

The upcoming STEREO mission's IMPACT and PLASTIC investigations will provide the first opportunity for long duration, detailed observations of 1 AU magnetic field structures, plasma ions and electrons, suprathermal electrons, and energetic particles at points bracketing Earth's heliospheric location. Stereoscopic/3D information from the STEREO SECCHI imagers and SWAVES radio experiment will make it possible to use both multipoint and quadrature studies to connect interplanetary Coronal Mass Ejections (ICME) and solar wind structures to CMEs and coronal holes observed at the Sun. To fully exploit these unique data sets, tight integration with similarly equipped missions at L1 will be essential, particularly WIND and ACE. The STEREO mission is building novel data analysis tools to take advantage of the mission's scientific potential. These tools will require reliable access and a well-documented interface to the L1 data sets. Such an interface already exists for ACE through the ACE Science Center. We plan to provide a similar service for the WIND mission that will supplement existing CDAWeb services. Building on tools also being developed for STEREO, we will create a SOAP application program interface (API) which will allow both our STEREO/WIND/ACE interactive browser and third-party software to access WIND data as a seamless and integral part of the STEREO mission. The API will also allow for more advanced forms of data mining than currently available through other data web services. Access will be provided to WIND-specific data analysis software as well. The development of cross-spacecraft data analysis tools will allow a larger scientific community to combine STEREO's unique in-situ data with those of other missions, particularly the L1 missions, and, therefore, to maximize STEREO's scientific potential in gaining a greater understanding of the heliosphere.

Study on Multi-stage Logistics System Design Problem with Inventory Considering Demand Change by Hybrid Genetic Algorithm

NASA Astrophysics Data System (ADS)

Inoue, Hisaki; Gen, Mitsuo

The logistics model used in this study is 3-stage model employed by an automobile company, which aims to solve traffic problems at a total minimum cost. Recently, research on the metaheuristics method has advanced as an approximate means for solving optimization problems like this model. These problems can be solved using various methods such as the genetic algorithm (GA), simulated annealing, and tabu search. GA is superior in robustness and adjustability toward a change in the structure of these problems. However, GA has a disadvantage in that it has a slightly inefficient search performance because it carries out a multi-point search. A hybrid GA that combines another method is attracting considerable attention since it can compensate for a fault to a partial solution that early convergence gives a bad influence on a result. In this study, we propose a novel hybrid random key-based GA(h-rkGA) that combines local search and parameter tuning of crossover rate and mutation rate; h-rkGA is an improved version of the random key-based GA (rk-GA). We attempted comparative experiments with spanning tree-based GA, priority based GA and random key-based GA. Further, we attempted comparative experiments with “h-GA by only local search” and “h-GA by only parameter tuning”. We reported the effectiveness of the proposed method on the basis of the results of these experiments.

Multishaker modal testing

NASA Technical Reports Server (NTRS)

Craig, R. R., Jr.

1983-01-01

Procedures for improving the modal modeling of structures using test data and to determine appropriate analytical models based on substructure experimental data were explored. Two related research topics were considered in modal modeling: using several independently acquired columns of frequency response data, and modal modeling using simultaneous multi-point excitation. In component mode synthesis modeling, the emphasis is on determining the best way to employ complex modes and residuals.

Erratum: “Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment” [Rev. Sci. Instrum. 83, 10D516 (2012)

DOE PAGES

Burke, Marcus G.; Fonck, Raymond J.; Bongard, Michael W.; ...

2016-07-18

This article corrects an error in M.G. Burke et al., 'Multi-point, high-speed passive ion velocity distribution diagnostic on the Pegasus Toroidal Experiment,' Rev. Sci. Instrum. 83, 10D516 (2012) pertaining to ion temperature. The conclusions of this paper are not altered by the revised ion temperature measurements.

Statistical symmetries of the Lundgren-Monin-Novikov hierarchy.

PubMed

Wacławczyk, Marta; Staffolani, Nicola; Oberlack, Martin; Rosteck, Andreas; Wilczek, Michael; Friedrich, Rudolf

2014-07-01

It was shown by Oberlack and Rosteck [Discr. Cont. Dyn. Sys. S, 3, 451 2010] that the infinite set of multipoint correlation (MPC) equations of turbulence admits a considerable extended set of Lie point symmetries compared to the Galilean group, which is implied by the original set of equations of fluid mechanics. Specifically, a new scaling group and an infinite set of translational groups of all multipoint correlation tensors have been discovered. These new statistical groups have important consequences for our understanding of turbulent scaling laws as they are essential ingredients of, e.g., the logarithmic law of the wall and other scaling laws, which in turn are exact solutions of the MPC equations. In this paper we first show that the infinite set of translational groups of all multipoint correlation tensors corresponds to an infinite dimensional set of translations under which the Lundgren-Monin-Novikov (LMN) hierarchy of equations for the probability density functions (PDF) are left invariant. Second, we derive a symmetry for the LMN hierarchy which is analogous to the scaling group of the MPC equations. Most importantly, we show that this symmetry is a measure of the intermittency of the velocity signal and the transformed functions represent PDFs of an intermittent (i.e., turbulent or nonturbulent) flow. Interesting enough, the positivity of the PDF puts a constraint on the group parameters of both shape and intermittency symmetry, leading to two conclusions. First, the latter symmetries may no longer be Lie group as under certain conditions group properties are violated, but still they are symmetries of the LMN equations. Second, as the latter two symmetries in its MPC versions are ingredients of many scaling laws such as the log law, the above constraints implicitly put weak conditions on the scaling parameter such as von Karman constant κ as they are functions of the group parameters. Finally, let us note that these kind of statistical symmetries are of much more general type, i.e., not limited to MPC or PDF equations emerging from Navier-Stokes, but instead they are admitted by other nonlinear partial differential equations like, for example, the Burgers equation when in conservative form and if the nonlinearity is quadratic.

Modification of SR-PSOX functions by multi-point mutations of basic amino acid residues.

PubMed

Liu, Weiwei; Yin, Lan; Dai, Yalei

2013-02-01

SR-PSOX can function as a scavenger receptor, a chemokine and an adhesion molecule, and it could be an interesting player in the formation of atherosclerotic lesions. Our previous studies demonstrated that basic amino acid residues in the chemokine domain of SR-PSOX are critical for its functions. In this study the combinations of the key basic amino acids in the chemokine domain of SR-PSOX have been identified. Five combinations of basic amino acid residues that may form conformational motif for SR-PSOX functions were selected for multi-point mutants. The double mutants of K61AR62A, R76AK79A, R82AH85A, and treble mutants of R76AR78AK79A, R78AR82AH85A were successfully constructed by replacing the combinations of two or three basic amino acid residues with alanine. After successful expression of these mutants on the cells, the functional studies showed that the cells expressing R76AK79A and R82AH85A mutants significantly increased the activity of oxLDL uptake compared with that of wild-type SR-PSOX. Meanwhile, the cells expressing R76AK79A mutant also dramatically enhanced the phagocytotic activity of SR-PSOX. However, the cells expressing the construct of combination of R78A mutation in R76AK79A or R82AH85A could abolish these effects. More interestingly, the adhesive activities were remarkably down regulated in the cells expressing the multi-point mutants respectively. This study revealed that some conformational motifs of basic amino acid residues, especially R76 with K79 in SR-PSOX, may form a common functional motif for its critical functions. R78 in SR-PSOX has the potential action to stabilize the function of oxLDL uptake and bacterial phagocytosis. The results obtained may provide new insight for the development of drug target of atherosclerosis. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Peace Corps Partnered Health Services Implementation Research in Global Health: Opportunity for Impact

PubMed Central

Hedrick, Chris; Ndiaye, Youssoupha; Linn, Annē

2014-01-01

Background: There is abundant evidence of the affordable, life-saving interventions effective at the local primary health care level in low- and middle-income countries (LMICs). However, the understanding of how to deliver those interventions in diverse settings is limited. Primary healthcare services implementation research is needed to elucidate the contextual factors that can influence the outcomes of interventions, especially at the local level. US universities commonly collaborate with LMIC universities, communities, and health system partners for health services research but common barriers exist. Current challenges include the capacity to establish an ongoing presence in local settings in order to facilitate close collaboration and communication. The Peace Corps is an established development organization currently aligned with local health services in many LMICs and is well-positioned to facilitate research partnerships. This article explores the potential of a community–Peace Corps–academic partnership approach to conduct local primary healthcare services implementation research. Discussion: The Peace Corps is well positioned to offer insights into local contextual factors because volunteers work closely with local leaders, have extensive trust within local communities, and have an ongoing, constant, well-integrated presence. However, the Peace Corps does not routinely conduct primary healthcare services implementation research. Universities, within the United States and locally, could benefit from the established resources and trust of the Peace Corps to conduct health services implementation research to advance access to local health services and further the knowledge of real world application of local health services in a diversity of settings. The proposed partnership would consist of (1) a local community advisory board and local health system leaders, (2) Peace Corps volunteers, and (3) a US-LMIC academic institutional collaboration. Within the proposed partnership approach, the contributions of each partner are as follows: the local community and health system leadership guides the work in consideration of local priorities and context; the Peace Corps provides logistical support, community expertise, and local trust; and the academic institutions offer professional technical and public health educational and training resources and research support. Conclusion: The Peace Corps offers the opportunity to enhance a community-academic partnership in LMICs through community-level guidance, logistical assistance, and research support for community based participatory primary health-care services implementation research that addresses local primary healthcare priorities. PMID:25568819

Peace corps partnered health services implementation research in global health: opportunity for impact.

PubMed

Dykens, Andrew; Hedrick, Chris; Ndiaye, Youssoupha; Linn, Annē

2014-09-01

There is abundant evidence of the affordable, life-saving interventions effective at the local primary health care level in low- and middle-income countries (LMICs). However, the understanding of how to deliver those interventions in diverse settings is limited. Primary healthcare services implementation research is needed to elucidate the contextual factors that can influence the outcomes of interventions, especially at the local level. US universities commonly collaborate with LMIC universities, communities, and health system partners for health services research but common barriers exist. Current challenges include the capacity to establish an ongoing presence in local settings in order to facilitate close collaboration and communication. The Peace Corps is an established development organization currently aligned with local health services in many LMICs and is well-positioned to facilitate research partnerships. This article explores the potential of a community-Peace Corps-academic partnership approach to conduct local primary healthcare services implementation research. The Peace Corps is well positioned to offer insights into local contextual factors because volunteers work closely with local leaders, have extensive trust within local communities, and have an ongoing, constant, well-integrated presence. However, the Peace Corps does not routinely conduct primary healthcare services implementation research. Universities, within the United States and locally, could benefit from the established resources and trust of the Peace Corps to conduct health services implementation research to advance access to local health services and further the knowledge of real world application of local health services in a diversity of settings. The proposed partnership would consist of (1) a local community advisory board and local health system leaders, (2) Peace Corps volunteers, and (3) a US-LMIC academic institutional collaboration. Within the proposed partnership approach, the contributions of each partner are as follows: the local community and health system leadership guides the work in consideration of local priorities and context; the Peace Corps provides logistical support, community expertise, and local trust; and the academic institutions offer professional technical and public health educational and training resources and research support. The Peace Corps offers the opportunity to enhance a community-academic partnership in LMICs through community-level guidance, logistical assistance, and research support for community based participatory primary health-care services implementation research that addresses local primary healthcare priorities.

Transient Calibration of a Variably-Saturated Groundwater Flow Model By Iterative Ensemble Smoothering: Synthetic Case and Application to the Flow Induced During Shaft Excavation and Operation of the Bure Underground Research Laboratory

NASA Astrophysics Data System (ADS)

Lam, D. T.; Kerrou, J.; Benabderrahmane, H.; Perrochet, P.

2017-12-01

The calibration of groundwater flow models in transient state can be motivated by the expected improved characterization of the aquifer hydraulic properties, especially when supported by a rich transient dataset. In the prospect of setting up a calibration strategy for a variably-saturated transient groundwater flow model of the area around the ANDRA's Bure Underground Research Laboratory, we wish to take advantage of the long hydraulic head and flowrate time series collected near and at the access shafts in order to help inform the model hydraulic parameters. A promising inverse approach for such high-dimensional nonlinear model, and which applicability has been illustrated more extensively in other scientific fields, could be an iterative ensemble smoother algorithm initially developed for a reservoir engineering problem. Furthermore, the ensemble-based stochastic framework will allow to address to some extent the uncertainty of the calibration for a subsequent analysis of a flow process dependent prediction. By assimilating the available data in one single step, this method iteratively updates each member of an initial ensemble of stochastic realizations of parameters until the minimization of an objective function. However, as it is well known for ensemble-based Kalman methods, this correction computed from approximations of covariance matrices is most efficient when the ensemble realizations are multi-Gaussian. As shown by the comparison of the updated ensemble mean obtained for our simplified synthetic model of 2D vertical flow by using either multi-Gaussian or multipoint simulations of parameters, the ensemble smoother fails to preserve the initial connectivity of the facies and the parameter bimodal distribution. Given the geological structures depicted by the multi-layered geological model built for the real case, our goal is to find how to still best leverage the performance of the ensemble smoother while using an initial ensemble of conditional multi-Gaussian simulations or multipoint simulations as conceptually consistent as possible. Performance of the algorithm including additional steps to help mitigate the effects of non-Gaussian patterns, such as Gaussian anamorphosis, or resampling of facies from the training image using updated local probability constraints will be assessed.

The development of estimated methodology for interfacial adhesion of semiconductor coatings having an enormous mismatch extent

NASA Astrophysics Data System (ADS)

Lee, Chang-Chun; Huang, Pei-Chen

2018-05-01

The long-term reliability of multi-stacked coatings suffering the bending or rolling load was a severe challenge to extend the lifespan of foregoing structure. In addition, the adhesive strength of dissimilar materials was regarded as the major mechanical reliability concerns among multi-stacked films. However, the significant scale-mismatch from several nano-meter to micro-meter among the multi-stacked coatings causing the numerical accuracy and converged capability issues on fracture-based simulation approach. For those reasons, this study proposed the FEA-based multi-level submodeling and multi-point constraint (MPC) technique to conquer the foregoing scale-mismatch issue. The results indicated that the decent region of first and second-order submodeling can achieve the small error of 1.27% compared with the experimental result and significantly reduced the mesh density and computing time. Moreover, the MPC method adopted in FEA simulation also shown only 0.54% error when the boundary of selected local region was away the concerned critical region following the Saint-Venant principle. In this investigation, two FEA-based approaches were used to conquer the evidently scale mismatch issue when the adhesive strengths of micro and nano-scale multi-stacked coating were taken into account.

Portable microcontroller-based instrument for near-infrared spectroscopy

NASA Astrophysics Data System (ADS)

Giardini, Mario E.; Corti, Mario; Lago, Paolo; Gelmetti, Andrea

2000-05-01

Near IR Spectroscopy (NIRS) can be employed to noninvasively and continuously measure in-vivo local changes in haemodynamics and oxygenation of human tissues. In particular, the technique can be particularly useful for muscular functional monitoring. We present a portable NIRS research-grade acquisition system prototype, strictly dedicate to low-noise measurements during muscular exercise. The prototype is able to control four LED sources and a detector. Such a number of sources allows for multipoint measurements or for multi-wavelength spectroscopy of tissue constituents other than oxygen, such as cytochrome aa3 oxidation. The LEDs and the detector are mounted on separate probes, which carry also the relevant drivers and preamplifiers. By employing surface-mount technologies, probe size and weight are kept to a minimum. A single-chip mixed-signal RISC microcontroller performs source-to- detector multiplexing with a digital correlation technique. The acquired data are stored on an on-board 64 K EEPROM bank, and can be subsequently uploaded to a personal computer via serial port for further analysis. The resulting instrument is compact and lightweight. Preliminary test of the prototype on oxygen consumption during tourniquet- induced forearm ischaemia show adequate detectivity and time response.

Community Coordinated Modeling Center Support of Science Needs for Integrated Data Environment

NASA Technical Reports Server (NTRS)

Kuznetsova, M. M.; Hesse, M.; Rastatter, L.; Maddox, M.

2007-01-01

Space science models are essential component of integrated data environment. Space science models are indispensable tools to facilitate effective use of wide variety of distributed scientific sources and to place multi-point local measurements into global context. The Community Coordinated Modeling Center (CCMC) hosts a set of state-of-the- art space science models ranging from the solar atmosphere to the Earth's upper atmosphere. The majority of models residing at CCMC are comprehensive computationally intensive physics-based models. To allow the models to be driven by data relevant to particular events, the CCMC developed an online data file generation tool that automatically downloads data from data providers and transforms them to required format. CCMC provides a tailored web-based visualization interface for the model output, as well as the capability to download simulations output in portable standard format with comprehensive metadata and user-friendly model output analysis library of routines that can be called from any C supporting language. CCMC is developing data interpolation tools that enable to present model output in the same format as observations. CCMC invite community comments and suggestions to better address science needs for the integrated data environment.

Multipoint Space Measurements of TGF's with the TRYAD Mission

NASA Astrophysics Data System (ADS)

Fuchs, J.; Briggs, M. S.; Jenke, P.

2017-12-01

The Terrestrial RaY Analysis and Detection (TRYAD) is a twin 6U cubesat mission designed to detect Terrestrial Gamma-ray Flashes (TGF's) from low earth orbit. Current observations of TGF's are predominantly done from single point measurements; the objective of this mission is to capture two simultaneous observations to identify a characteristic beam profile. Working models for production of TGF's suggest two main scenarios exist: one being creation in the lightening step leader which results in a wider beam profile, the other is a larger field effect in the storm resulting in a narrow beam. The TRYAD detector consists of four plastic scintillation bars that will detect flux correlated with GPS position and time. Both satellites will fly at a controlled separation of several hundred kilometers gathering data over the tropics. The data gathered from the spacecraft are matched to lightening data from the World Wide Lightning Location Network (WWLLN) to get ground and time localization along with the two point flux measurement. TRYAD will fly in 2019. We will present simulations describing TRYADs ability to discriminate between current TGF models, the TRYAD science instrument, along with its capabilities and impact for TGF science.

In Situ Observation of Hard Surrounding Rock Displacement at 2400-m-Deep Tunnels

NASA Astrophysics Data System (ADS)

Feng, Xia-Ting; Yao, Zhi-Bin; Li, Shao-Jun; Wu, Shi-Yong; Yang, Cheng-Xiang; Guo, Hao-Sen; Zhong, Shan

2018-03-01

This paper presents the results of in situ investigation of the internal displacement of hard surrounding rock masses within deep tunnels at China's Jinping Underground Laboratory Phase II. The displacement evolution of the surrounding rock during the entire excavation processes was monitored continuously using pre-installed continuous-recording multi-point extensometers. The evolution of excavation-damaged zones and fractures in rock masses were also observed using acoustic velocity testing and digital borehole cameras, respectively. The results show four kinds of displacement behaviours of the hard surrounding rock masses during the excavation process. The displacement in the inner region of the surrounding rock was found to be greater than that of the rock masses near the tunnel's side walls in some excavation stages. This leads to a multi-modal distribution characteristic of internal displacement for hard surrounding rock masses within deep tunnels. A further analysis of the evolution information on the damages and fractures inside the surrounding rock masses reveals the effects of excavation disturbances and local geological conditions. This recognition can be used as the reference for excavation and supporting design and stability evaluations of hard-rock tunnels under high-stress conditions.

Localization of a gene responsible for nonspecific mental retardation (MRX9) to the pericentromeric region of the X chromosome

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willems, P.; Vits, L.; Buntinx, I.

1993-11-01

Nonspecific X-linked mental retardation (MRX) includes several distinct entities with mental retardation but without additional distinguishing features. The MRX family reported here has been classified previously as MRX9. In this study, the authors performed linkage analysis of MRX9 with a panel of 43 polymorphic DNA markers dispersed over chromosome X. Two-point linkage analysis revealed lod scores of 3.52 and 3.82 at 0% recombination for OATL1 and MAOA, both located in Xp11.2-p11.4. Lod scores for linkage with PGK1P1, DXS106, and DXS132, all located in Xq11-q13, were 3.83, 3.82, and 3.52, respectively, all at 0% recombination. Multipoint linkage analysis showed two peaksmore » with MAOA and DXS132/DXS106, respectively. Analysis of recombinational events indicated a position of the MRX9 gene between DXS164 and DXS453. These findings are compatible with a location of the MRX9 gene in the pericentromeric region of the X chromosome at Xp21-q13. 26 refs., 3 figs., 2 tabs.« less

A Multi-Point Measurement Method for Thermal Characterization of Foil Bearings Using Customized Thermocouples

NASA Astrophysics Data System (ADS)

Lubieniecki, Michał; Roemer, Jakub; Martowicz, Adam; Wojciechowski, Krzysztof; Uhl, Tadeusz

2016-03-01

Gas foil bearings have become widespread covering the applications of micro-turbines, motors, compressors, and turbocharges, prevalently of small size. The specific construction of the bearing, despite all of its advantages, makes it vulnerable to a local difference in heat generation rates that can be extremely detrimental. The developing thermal gradients may lead to thermal runaway or seizure that eventually causes bearing failure, usually abrupt in nature. The authors propose a method for thermal gradient removal with the use of current-controlled thermoelectric modules. To fulfill the task of control law adoption the numerical model of the heat distribution in a bearing has been built. Although sparse readings obtained experimentally with standard thermocouples are enough to determine thermal gradients successfully, validation of the bearing numerical model may be impeded. To improve spatial resolution of the experimental measurements the authors proposed a matrix of customized thermocouples located on the top foil. The foil acts as a shared conductor for each thermocouple that reduces the number of cable connections. The proof of concept of the control and measurement systems has been demonstrated in a still bearing heated by a cartridge heater.

Localization of a Susceptibility Gene for Familial Nonmedullary Thyroid Carcinoma to Chromosome 2q21

PubMed Central

McKay, James D.; Lesueur, Fabienne; Jonard, Laurence; Pastore, Alessandro; Williamson, Jan; Hoffman, Linda; Burgess, John; Duffield, Anne; Papotti, Mauro; Stark, Markus; Sobol, Hagay; Maes, Béatrice; Murat, Arnaud; Kääriäinen, Helena; Bertholon-Grégoire, Mireille; Zini, Michele; Rossing, Mary Anne; Toubert, Marie-Elisabeth; Bonichon, Françoise; Cavarec, Marie; Bernard, Anne-Marie; Boneu, Andrée; Leprat, Frédéric; Haas, Oskar; Lasset, Christine; Schlumberger, Martin; Canzian, Federico; Goldgar, David E.; Romeo, Giovanni

2001-01-01

The familial form of nonmedullary thyroid carcinoma (NMTC) is a complex genetic disorder characterized by multifocal neoplasia and a higher degree of aggressiveness than its sporadic counterpart. In a large Tasmanian pedigree (Tas1) with recurrence of papillary thyroid carcinoma (PTC), the most common form of NMTC, an extensive genomewide scan revealed a common haplotype on chromosome 2q21 in seven of the eight patients with PTC. To verify the significance of the 2q21 locus, we performed linkage analysis in an independent sample set of 80 pedigrees, yielding a multipoint heterogeneity LOD score (HLOD) of 3.07 (α=0.42), nonparametric linkage (NPL) 3.19, (P=.001) at marker D2S2271. Stratification based on the presence of at least one case of the follicular variant of PTC, the phenotype observed in the Tas1 family, identified 17 such pedigrees, yielding a maximal HLOD score of 4.17 (α=0.80) and NPL=4.99 (P=.00002) at markers AFMa272zg9 and D2S2271, respectively. These results indicate the existence of a susceptibility locus for familial NMTC on chromosome 2q21. PMID:11438887

A new approach to tracer transport analysis: From fracture systems to strongly heterogeneous porous media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsang, Chin-Fu

Many current development and utilization of groundwater resources include a study of their flow and transport properties. These properties are needed in evaluating possible changes in groundwater quality and potential transport of hazardous solutes through the groundwater system. Investigation of transport properties of fractured rocks is an active area of research. Most of the current approaches to the study of flow and transport in fractured rocks cannot be easily used for analysis of tracer transport field data. A new approach is proposed based on a detailed study of transport through a fracture of variable aperture. This is a two-dimensional stronglymore » heterogeneous permeable system. It is suggested that tracer breakthrough curves can be analyzed based on an aperture or permeability probability distribution function that characterizes the tracer flow through the fracture. The results are extended to a multi-fracture system and can be equally applied to a strongly heterogeneous porous medium. Finally, the need for multi-point or line and areal tracer injection and observation tests is indicated as a way to avoid the sensitive dependence of point measurements on local permeability variability. 30 refs., 15 figs.« less

Low-Frequency Waves in the Near-Earth Magnetotail before Substorm Expansion Onsets

NASA Astrophysics Data System (ADS)

Miyashita, Y.; Saito, M. H.; Hiraki, Y.; Machida, S.

2013-12-01

Magnetic reconnection and dipolarization, which occur in the near-Earth magnetotail just before substorm expansion onsets, are important processes for the substorm triggering. To understand the triggering of these processes, we have investigated low-frequency waves that were observed in the near-Earth magnetotail before onsets, by performing statistical analysis based on Geotail observations and case studies based on multi-point THEMIS and Geotail observations. Here we focused our examination on ~10 min interval before onsets. We find that small-amplitude Alfven and slow-mode magnetosonic waves with a period of ~1 to 2 min continuously exist for more than 10 min before onsets. Such waves are seen not only in the initial dipolarization region but also midway between the magnetic reconnection and initial dipolarization regions. It seems that the amplitudes of the waves are larger in the off-equator plasma sheet and the plasma sheet boundary layer than at the magnetic equator and in the lobe. After onsets the waves considerably amplify in the plasma sheet. These results may imply that instabilities already begin to grow gradually in a wide region during the substorm growth phase, while their explosive growth begins in localized regions just before onsets.

New generation of the health monitoring system SMS 2001

NASA Astrophysics Data System (ADS)

Berndt, Rolf-Dietrich; Schwesinger, Peter

2001-08-01

The Structure Monitoring System SMS 2001 (applied for patent) represents a modular structured multi-component measurement devise for use under outdoor conditions. Besides usual continuously (static) measurements of e.g. environmental parameters and structure related responses the SMS is able to register also short term dynamic events automatically with measurement frequencies up to 1 kHz. A larger range of electrical sensors is able to be used. On demand a solar based power supply can be realized. The SMS 2001 is adaptable in a wide range, it is space-saving in its geometric structure and can meet very various demands of the users. The system is applicable preferably for small and medium sized concrete and steel structures (besides buildings and bridges also for special cases). It is suitable to support the efficient concept of a controlled life time extension especially in the case of pre-damaged structures. The interactive communication between SMS and the central office is completely remote controlled. Two point or multi-point connections using the internet can be realized. The measurement data are stored in a central data bank. A safe access supported by software modules can be organized in different levels, e.g. for scientific evaluation, service reasons or needs of authorities.

Low Power Multi-Hop Networking Analysis in Intelligent Environments.

PubMed

Etxaniz, Josu; Aranguren, Gerardo

2017-05-19

Intelligent systems are driven by the latest technological advances in many different areas such as sensing, embedded systems, wireless communications or context recognition. This paper focuses on some of those areas. Concretely, the paper deals with wireless communications issues in embedded systems. More precisely, the paper combines the multi-hop networking with Bluetooth technology and a quality of service (QoS) metric, the latency. Bluetooth is a radio license-free worldwide communication standard that makes low power multi-hop wireless networking available. It establishes piconets (point-to-point and point-to-multipoint links) and scatternets (multi-hop networks). As a result, many Bluetooth nodes can be interconnected to set up ambient intelligent networks. Then, this paper presents the results of the investigation on multi-hop latency with park and sniff Bluetooth low power modes conducted over the hardware test bench previously implemented. In addition, the empirical models to estimate the latency of multi-hop communications over Bluetooth Asynchronous Connectionless Links (ACL) in park and sniff mode are given. The designers of devices and networks for intelligent systems will benefit from the estimation of the latency in Bluetooth multi-hop communications that the models provide.

Low Power Multi-Hop Networking Analysis in Intelligent Environments

PubMed Central

Etxaniz, Josu; Aranguren, Gerardo

2017-01-01

Intelligent systems are driven by the latest technological advances in many different areas such as sensing, embedded systems, wireless communications or context recognition. This paper focuses on some of those areas. Concretely, the paper deals with wireless communications issues in embedded systems. More precisely, the paper combines the multi-hop networking with Bluetooth technology and a quality of service (QoS) metric, the latency. Bluetooth is a radio license-free worldwide communication standard that makes low power multi-hop wireless networking available. It establishes piconets (point-to-point and point-to-multipoint links) and scatternets (multi-hop networks). As a result, many Bluetooth nodes can be interconnected to set up ambient intelligent networks. Then, this paper presents the results of the investigation on multi-hop latency with park and sniff Bluetooth low power modes conducted over the hardware test bench previously implemented. In addition, the empirical models to estimate the latency of multi-hop communications over Bluetooth Asynchronous Connectionless Links (ACL) in park and sniff mode are given. The designers of devices and networks for intelligent systems will benefit from the estimation of the latency in Bluetooth multi-hop communications that the models provide. PMID:28534847

Design and FPGA implementation for MAC layer of Ethernet PON

NASA Astrophysics Data System (ADS)

Zhu, Zengxi; Lin, Rujian; Chen, Jian; Ye, Jiajun; Chen, Xinqiao

2004-04-01

Ethernet passive optical network (EPON), which represents the convergence of low-cost, high-bandwidth and supporting multiple services, appears to be one of the best candidates for the next-generation access network. The work of standardizing EPON as a solution for access network is still underway in the IEEE802.3ah Ethernet in the first mile (EFM) task force. The final release is expected in 2004. Up to now, there has been no standard application specific integrated circuit (ASIC) chip available which fulfills the functions of media access control (MAC) layer of EPON. The MAC layer in EPON system has many functions, such as point-to-point emulation (P2PE), Ethernet MAC functionality, multi-point control protocol (MPCP), network operation, administration and maintenance (OAM) and link security. To implement those functions mentioned above, an embedded real-time operating system (RTOS) and a flexible programmable logic device (PLD) with an embedded processor are used. The software and hardware functions in MAC layer are realized through programming embedded microprocessor and field programmable gate array(FPGA). Finally, some experimental results are given in this paper. The method stated here can provide a valuable reference for developing EPON MAC layer ASIC.

Reducing inequalities in access to health care: developing a toolkit through action research.

PubMed

Goyder, E C; Blank, L; Ellis, E; Furber, A; Peters, J; Sartain, K; Massey, C

2005-10-01

Healthcare organisations are expected both to monitor inequalities in access to health services and also to act to improve access and increase equity in service provision. Locally developed action research projects with an explicit objective of reducing inequalities in access. Eight different health care services in the Yorkshire and Humber region, including community based palliative care, general practice asthma care, hospital based cardiology clinics, and termination of pregnancy services. Changes in service provision, increasing attendance rates in targeted groups. Local teams identified the population concerned and appropriate interventions using both published and grey literature. Where change to service provision was achieved, local data were collected to monitor the impact of service change. A number of evidence based changes to service provision were proposed and implemented with variable success. Service uptake increased in some of the targeted populations. Interventions to improve access must be sensitive to local settings and need both practical and managerial support to succeed. It is particularly difficult to improve access effectively if services are already struggling to meet current demand. Key elements for successful interventions included effective local leadership, identification of an intervention which is both evidence based and locally practicable, and identification of additional resources to support increased activity. A "toolkit" has been developed to support the identification and implementation of appropriate changes.

Automated soil gas monitoring chamber

DOEpatents

Edwards, Nelson T.; Riggs, Jeffery S.

2003-07-29

A chamber for trapping soil gases as they evolve from the soil without disturbance to the soil and to the natural microclimate within the chamber has been invented. The chamber opens between measurements and therefore does not alter the metabolic processes that influence soil gas efflux rates. A multiple chamber system provides for repetitive multi-point sampling, undisturbed metabolic soil processes between sampling, and an essentially airtight sampling chamber operating at ambient pressure.

Smart architecture for stable multipoint fiber Bragg grating sensor system

NASA Astrophysics Data System (ADS)

Yeh, Chien-Hung; Tsai, Ning; Zhuang, Yuan-Hong; Huang, Tzu-Jung; Chow, Chi-Wai; Chen, Jing-Heng; Liu, Wen-Fung

2017-12-01

In this work, we propose and investigate an intelligent fiber Bragg grating (FBG)-based sensor system in which the proposed stabilized and wavelength-tunable single-longitudinal-mode erbium-doped fiber laser can improve the sensing accuracy of wavelength-division-multiplexing multiple FBG sensors in a longer fiber transmission distance. Moreover, we also demonstrate the proposed sensor architecture to enhance the FBG capacity for sensing strain and temperature, simultaneously.

Noise Identification in a Hot Transonic Jet Using Low-Dimensional Methods

DTIC Science & Technology

2008-03-01

calibration between the nozzle static pressure (transducer) and total pressure ( pitot probe) reveals a nearly linear relationship between the two, exhibiting... rakes of hot-wires. Multi-point correlations of velocity components coupled with assumptions of homogeneity and periodicity in the jet flow flied...axisymmetric incompressible jet at one downstream position using an in-house designed rake of 138 hot-wires. The experiment was then carried out at multiple

Edison Demonstration of Smallsat Networks

NASA Technical Reports Server (NTRS)

Westley, Deborah; Martinez, Andres; Petro, Andrew

2015-01-01

The goal of NASA's Edison Demonstration of Smallsat Networks (EDSN) mission is to demonstrate interactive satellite swarms capable of collecting, exchanging and transmitting multi-point scientific measurements. Satellite swarms enable a wide array of scientific, commercial and academic research not achievable with a single satellite. The EDSN satellites are scheduled to be launched into space as secondary payloads on the first flight of the Super Strypi launch vehicle no earlier than Oct. 29, 2015.

KSC-06pd0259

NASA Image and Video Library

2005-12-27

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences Building 1555 at Vandenberg Air Force Base in California, workers attach segments of the Pegasus XL rocket that will launch the Space Technology 5 spacecraft later this month. ST5 contains three micro-satellites that will be positioned in a "string of pearls" constellation to perform simultaneous multi-point measurements of the Earth's magnetic field using highly sensitive magnetometers. The scheduled launch date is Feb. 28.

Simultaneous and multi-point measurement of ammonia emanating from human skin surface for the estimation of whole body dermal emission rate.

PubMed

Furukawa, Shota; Sekine, Yoshika; Kimura, Keita; Umezawa, Kazuo; Asai, Satomi; Miyachi, Hayato

2017-05-15

Ammonia is one of the members of odor gases and a possible source of odor in indoor environment. However, little has been known on the actual emission rate of ammonia from the human skin surface. Then, this study aimed to estimate the whole-body dermal emission rate of ammonia by simultaneous and multi-point measurement of emission fluxes of ammonia employing a passive flux sampler - ion chromatography system. Firstly, the emission fluxes of ammonia were non-invasively measured for ten volunteers at 13 sampling positions set in 13 anatomical regions classified by Kurazumi et al. The measured emission fluxes were then converted to partial emission rates using the surface body areas estimated by weights and heights of volunteers and partial rates of 13 body regions. Subsequent summation of the partial emission rates provided the whole body dermal emission rate of ammonia. The results ranged from 2.9 to 12mgh -1 with an average of 5.9±3.2mgh -1 per person for the ten healthy young volunteers. The values were much greater than those from human breath, and thus the dermal emission of ammonia was found more significant odor source than the breath exhalation in indoor environment. Copyright © 2017 Elsevier B.V. All rights reserved.

Space Technology 5 Multi-Point Observations of Temporal Variability of Field-Aligned Currents

NASA Technical Reports Server (NTRS)

Le, Guan; Wang, Yongli; Slavin, James A.; Strangeway, Robert J.

2008-01-01

Space Technology 5 (ST5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations. In this paper, we present a study of the temporal variability of field-aligned currents using multi-point magnetic field measurements from ST5. The data demonstrate that meso-scale current structures are commonly embedded within large-scale field-aligned current sheets. The meso-scale current structures are very dynamic with highly variable current density and/or polarity in time scales of approximately 10 min. They exhibit large temporal variations during both quiet and disturbed times in such time scales. On the other hand, the data also shown that the time scales for the currents to be relatively stable are approximately 1 min for meso-scale currents and approximately 10 min for large scale current sheets. These temporal features are obviously associated with dynamic variations of their particle carriers (mainly electrons) as they respond to the variations of the parallel electric field in auroral acceleration region. The characteristic time scales for the temporal variability of meso-scale field-aligned currents are found to be consistent with those of auroral parallel electric field.

Space Technology 5 Multi-point Observations of Field-aligned Currents: Temporal Variability of Meso-Scale Structures

NASA Technical Reports Server (NTRS)

Le, Guan; Wang, Yongli; Slavin, James A.; Strangeway, Robert J.

2007-01-01

Space Technology 5 (ST5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations. In this paper, we present a study of the temporal variability of field-aligned currents using multi-point magnetic field measurements from ST5. The data demonstrate that meso-scale current structures are commonly embedded within large-scale field-aligned current sheets. The meso-scale current structures are very dynamic with highly variable current density and/or polarity in time scales of - 10 min. They exhibit large temporal variations during both quiet and disturbed times in such time scales. On the other hand, the data also shown that the time scales for the currents to be relatively stable are approx. 1 min for meso-scale currents and approx. 10 min for large scale current sheets. These temporal features are obviously associated with dynamic variations of their particle carriers (mainly electrons) as they respond to the variations of the parallel electric field in auroral acceleration region. The characteristic time scales for the temporal variability of meso-scale field-aligned currents are found to be consistent with those of auroral parallel electric field.

Space Technology 5 (ST-5) Multipoint Observations of Temporal and Spatial Variability of Field-Aligned Currents

NASA Technical Reports Server (NTRS)

Le, Guan

2010-01-01

Space Technology 5 (ST-5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations. In this paper, we present a study of the temporal variability of field-aligned currents using multi-point magnetic field measurements from ST5. The data demonstrate that mesoscale current structures are commonly embedded within large-scale field-aligned current sheets. The meso-scale current structures are very dynamic with highly variable current density and/or polarity in time scales of about 10 min. They exhibit large temporal variations during both quiet and disturbed times in such time scales. On the other hand, the data also shown that the time scales for the currents to be relatively stable are about 1 min for meso-scale currents and about 10 min for large scale current sheets. These temporal features are obviously associated with dynamic variations of their particle carriers (mainly electrons) as they respond to the variations of the parallel electric field in auroral acceleration region. The characteristic time scales for the temporal variability of meso-scale field-aligned currents are found to be consistent with those of auroral parallel electric field.

Linkage analysis of idiopathic generalized epilepsy (IGE) and marker loci on chromosome 6p in families of patients with juvenile myocloni epilepsy: No evidence for an epilepsy locus in the HLA region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitehouse, W.P.; Rees, M.; Curtis, D.

1993-09-01

Evidence for a locus (EJM1) in the HLA region of chromosome 6p predisposing to idiopathic generalized epilepsy (IGE) in the families of patients with juvenile myoclonic epilepsy (JME) has been obtained in two previous studies of separately ascertained groups of kindreds. Linkage analysis has been undertaken in a third set of 25 families including a patient with JME and at least one first-degree relative with IGE. Family members were typed for eight polymorphic loci on chromosome 6p: F13A, D6889, D6S109, D6S105, D6S10, C4B, DQA1/A2, and TCTE1. Pairwise and multipoint linkage analysis was carried out assuming autosomal dominant and autosomal recessivemore » inheritance and age-dependent high or low penetrance. No significant evidence in favor of linkage was obtained at any locus. Multipoint linkage analysis generated significant exclusion data (lod score < -2.0) at HLA and for a region 10-30 cM telomeric to HLA, the extent of which varied with the level of penetrance assumed. These observations indicate that genetic heterogeneity exists within this epilepsy phenotype. 39 refs., 4 figs., 2 tabs.« less

Green coconut fiber: a novel carrier for the immobilization of commercial laccase by covalent attachment for textile dyes decolourization.

PubMed

Cristóvão, Raquel O; Silvério, Sara C; Tavares, Ana P M; Brígida, Ana Iraidy S; Loureiro, José M; Boaventura, Rui A R; Macedo, Eugénia A; Coelho, Maria Alice Z

2012-09-01

Commercial laccase formulation was immobilized on modified green coconut fiber silanized with 3-glycidoxypropyltrimethoxysilane, aiming to achieve a cheap and effective biocatalyst. Two different strategies were followed: one point (pH 7.0) and multipoint (pH 10.0) covalent attachment. The influence of immobilization time on enzymatic activity and the final reduction with sodium borohydride were evaluated. The highest activities were achieved after 2 h of contact time in all situations. Commercial laccase immobilized at pH 7.0 was found to have higher activity and higher affinity to the substrate. However, the immobilization by multipoint covalent attachment improved the biocatalyst thermal stability at 50 °C, when compared to soluble enzyme and to the immobilized enzyme at pH 7.0. The Schiff's bases reduction by sodium borohydride, in spite of causing a decrease in enzyme activity, showed to contribute to the increase of operational stability through bonds stabilization. Finally, these immobilized enzymes showed high efficiency in the continuous decolourization of reactive textile dyes. In the first cycle, the decolourization is mainly due to dyes adsorption on the support. However, when working in successive cycles, the adsorption capacity of the support decreases (saturation) and the enzymatic action increases, indicating the applicability of this biocatalyst for textile wastewater treatment.

Examination of X chromosome markers in Rett syndrome: Exclusion mapping with a novel variation on multilocus linkage analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellison, K.A.; Fill, C.P.; Terwililger, J.

Rett syndrome is a neurologic disorder characterized by early normal development followed by regression, acquired deceleration of head growth, autism, ataxia, and sterotypic hand movements. The exclusive occurrence of the syndrome in females and the occurrence of a few familial cases with inheritance through maternal lines suggest that this disorder is most likely secondary to a mutation on the X chromosome. To address this hypothesis and to identify candidate regions for the Rett syndrome gene locus, genotypic analysis was performed in two families with maternally related affected half-sisters by using 63 DNA markers from the X chromosome. Nineteen of themore » loci studied were chosen for multipoint linkage analysis because they have been previously genetically mapped using a large number of meioses from reference families. Using the exclusion criterion of a lod score less than [minus]2, the authors were able to exclude the region between the Duchenne muscular dystrophy locus and the DXS456 locus. This region extends from Xp21.2 to Xq21-q23. The use of the multipoint linkage analysis approach outlined in this study should allow the exclusion of additional regions of the X chromosome as new markers are analyzed.« less

High-spatial-resolution electron density measurement by Langmuir probe for multi-point observations using tiny spacecraft

NASA Astrophysics Data System (ADS)

Hoang, H.; Røed, K.; Bekkeng, T. A.; Trondsen, E.; Clausen, L. B. N.; Miloch, W. J.; Moen, J. I.

2017-11-01

A method for evaluating electron density using a single fixed-bias Langmuir probe is presented. The technique allows for high-spatio-temporal resolution electron density measurements, which can be effectively carried out by tiny spacecraft for multi-point observations in the ionosphere. The results are compared with the multi-needle Langmuir probe system, which is a scientific instrument developed at the University of Oslo comprising four fixed-bias cylindrical probes that allow small-scale plasma density structures to be characterized in the ionosphere. The technique proposed in this paper can comply with the requirements of future small-sized spacecraft, where the cost-effectiveness, limited space available on the craft, low power consumption and capacity for data-links need to be addressed. The first experimental results in both the plasma laboratory and space confirm the efficiency of the new approach. Moreover, detailed analyses on two challenging issues when deploying the DC Langmuir probe on a tiny spacecraft, which are the limited conductive area of the spacecraft and probe surface contamination, are presented in the paper. It is demonstrated that the limited conductive area, depending on applications, can either be of no concern for the experiment or can be resolved by mitigation methods. Surface contamination has a small impact on the performance of the developed probe.

Familial isolated hyperparathyroidism is linked to a 1.7 Mb region on chromosome 2p13.3–14

PubMed Central

Warner, J; Nyholt, D R; Busfield, F; Epstein, M; Burgess, J; Stranks, S; Hill, P; Perry‐Keene, D; Learoyd, D; Robinson, B; Teh, B T; Prins, J B; Cardinal, J W

2006-01-01

Bachground Familial isolated hyperparathyroidism (FIHP) is an autosomal dominantly inherited form of primary hyperparathyroidism. Although comprising only about 1% of cases of primary hyperparathyroidism, identification and functional analysis of a causative gene for FIHP is likely to advance our understanding of parathyroid physiology and pathophysiology. Methods A genome‐wide screen of DNA from seven pedigrees with FIHP was undertaken in order to identify a region of genetic linkage with the disorder. Results Multipoint linkage analysis identified a region of suggestive linkage (LOD score 2.68) on chromosome 2. Fine mapping with the addition of three other families revealed significant linkage adjacent to D2S2368 (maximum multipoint LOD score 3.43). Recombination events defined a 1.7 Mb region of linkage between D2S2368 and D2S358 in nine pedigrees. Sequencing of the two most likely candidate genes in this region, however, did not identify a gene for FIHP. Conclusions We conclude that a causative gene for FIHP lies within this interval on chromosome 2. This is a major step towards eventual precise identification of a gene for FIHP, likely to be a key component in the genetic regulation of calcium homeostasis. PMID:16525030

New spatial upscaling methods for multi-point measurements: From normal to p-normal

NASA Astrophysics Data System (ADS)

Liu, Feng; Li, Xin

2017-12-01

Careful attention must be given to determining whether the geophysical variables of interest are normally distributed, since the assumption of a normal distribution may not accurately reflect the probability distribution of some variables. As a generalization of the normal distribution, the p-normal distribution and its corresponding maximum likelihood estimation (the least power estimation, LPE) were introduced in upscaling methods for multi-point measurements. Six methods, including three normal-based methods, i.e., arithmetic average, least square estimation, block kriging, and three p-normal-based methods, i.e., LPE, geostatistics LPE and inverse distance weighted LPE are compared in two types of experiments: a synthetic experiment to evaluate the performance of the upscaling methods in terms of accuracy, stability and robustness, and a real-world experiment to produce real-world upscaling estimates using soil moisture data obtained from multi-scale observations. The results show that the p-normal-based methods produced lower mean absolute errors and outperformed the other techniques due to their universality and robustness. We conclude that introducing appropriate statistical parameters into an upscaling strategy can substantially improve the estimation, especially if the raw measurements are disorganized; however, further investigation is required to determine which parameter is the most effective among variance, spatial correlation information and parameter p.

Linkage to 10q22 for maximum intraocular pressure and 1p32 for maximum cup-to-disc ratio in an extended primary open-angle glaucoma pedigree.

PubMed

Charlesworth, Jac C; Dyer, Thomas D; Stankovich, Jim M; Blangero, John; Mackey, David A; Craig, Jamie E; Green, Catherine M; Foote, Simon J; Baird, Paul N; Sale, Michèle M

2005-10-01

The purpose of this study was to identify genetic contributions to primary open-angle glaucoma (POAG) through investigations of two quantitative components of the POAG phenotype. Genome-wide multipoint variance-components linkage analyses of maximum recorded intraocular pressure (IOP) and maximum vertical cup-to-disc ratio were conducted on data from a single, large Australian POAG pedigree that has been found to segregate the myocilin Q368X mutation in some individuals. Multipoint linkage analysis of maximum recorded IOP produced a peak LOD score of 3.3 (P = 0.00015) near marker D10S537 on 10q22, whereas the maximum cup-to-disc ratio produced a peak LOD score of 2.3 (P = 0.00056) near markers D1S197 to D1S220 on 1p32. Inclusion of the myocilin Q368X mutation as a covariate provided evidence of an interaction between this mutation and the IOP and cup-to-disc ratio loci. Significant linkage has been identified for maximum IOP and suggestive linkage for vertical cup-to-disc ratio. Identification of genes contributing to the variance of these traits will enhance understanding of the pathophysiology of POAG as a whole.

MLAOS: A Multi-Point Linear Array of Optical Sensors for Coniferous Foliage Clumping Index Measurement

PubMed Central

Qu, Yonghua; Fu, Lizhe; Han, Wenchao; Zhu, Yeqing; Wang, Jindi

2014-01-01

The canopy foliage clumping effect is primarily caused by the non-random distribution of canopy foliage. Currently, measurements of clumping index (CI) by handheld instruments is typically time- and labor-intensive. We propose a low-cost and low-power automatic measurement system called Multi-point Linear Array of Optical Sensors (MLAOS), which consists of three above-canopy and nine below-canopy optical sensors that capture plant transmittance at different times of the day. Data communication between the MLAOS node is facilitated by using a ZigBee network, and the data are transmitted from the field MLAOS to a remote data server using the Internet. The choice of the electronic element and design of the MLAOS software is aimed at reducing costs and power consumption. A power consumption test showed that, when a 4000 mAH Li-ion battery is used, a maximum of 8–10 months of work can be achieved. A field experiment on a coniferous forest revealed that the CI of MLAOS may reveal a clumping effect that occurs within the canopy. In further work, measurement of the multi-scale clumping effect can be achieved by utilizing a greater number of MLAOS devices to capture the heterogeneity of the plant canopy. PMID:24859029

Characterizing the spatio-temporal and energy-dependent response of riometer absorption to particle precipitation

NASA Astrophysics Data System (ADS)

Kellerman, Adam; Makarevich, Roman; Spanswick, Emma; Donovan, Eric; Shprits, Yuri

2016-07-01

Energetic electrons in the 10's of keV range precipitate to the upper D- and lower E-region ionosphere, and are responsible for enhanced ionization. The same particles are important in the inner magnetosphere, as they provide a source of energy for waves, and thus relate to relativistic electron enhancements in Earth's radiation belts.In situ observations of plasma populations and waves are usually limited to a single point, which complicates temporal and spatial analysis. Also, the lifespan of satellite missions is often limited to several years which does not allow one to infer long-term climatology of particle precipitation, important for affecting ionospheric conditions at high latitudes. Multi-point remote sensing of the ionospheric plasma conditions can provide a global view of both ionospheric and magnetospheric conditions, and the coupling between magnetospheric and ionospheric phenomena can be examined on time-scales that allow comprehensive statistical analysis. In this study we utilize multi-point riometer measurements in conjunction with in situ satellite data, and physics-based modeling to investigate the spatio-temporal and energy-dependent response of riometer absorption. Quantifying this relationship may be a key to future advancements in our understanding of the complex D-region ionosphere, and may lead to enhanced specification of auroral precipitation both during individual events and over climatological time-scales.

The autosomal dominant familial exudative vitreoretinopathy locus maps on 11q and is closely linked to D11S533

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yuen; Schwinger, D.; Gal, A.

1992-10-01

Autosomal dominant familial exudative vitreoretinopathy (adFEVR) is a hereditary disorder characterized by the incomplete vascularization of the peripheral retina. The primary biochemical defect in adFEVR is unknown. The adFEVR locus has tentatively been assigned to 11q by linkage studies. The authors report the results of an extended multipoint linkage analysis of two families with adFEVR by using five markers (INT2, D11S533, D11S527, D11S35, and CD3D) from 11q13-q23. Pairwise linkage data obtained in the two families were rather similar and hence have not provided evidence for genetic heterogeneity. The highest compiled two-point lod score (3.67, at a recombination fraction of .07)more » was obtained for the disease locus versus D11S533. Multipoint analyses showed that the adFEVR locus maps most likely, with a maximum location score of over 20, between D11S533/D11S526 and D11S35, at recombination rates of .147 and .104, respectively. Close linkage without recombination (maximum lod score 11.26) has been found between D11S533 and D11S526. 15 refs., 3 figs., 4 tabs.« less

Distributed optical fiber vibration sensor based on Sagnac interference in conjunction with OTDR.

PubMed

Pan, Chao; Liu, Xiaorui; Zhu, Hui; Shan, Xuekang; Sun, Xiaohan

2017-08-21

A real-time distributed optical fiber vibration sensing prototype based on the Sagnac interference in conjunction with the optical time domain reflectometry (OTDR) was developed. The sensing mechanism for single- and multi-points vibrations along the sensing fiber was analyzed theoretically and demonstrated experimentally. The experimental results show excellent agreement with the theoretical models. It is verified that single-point vibration induces a significantly abrupt and monotonous power change in the corresponding position of OTDR trace. As to multi-points vibrations, the detection of the following vibration is influenced by all previous ones. However, if the distance between the adjacent two vibrations is larger than half of the input optical pulse width, abrupt power changes induced by them are separate and still monotonous. A time-shifting differential module was developed and carried out to convert vibration-induced power changes to pulses. Consequently, vibrations can be located accurately by measuring peak or valley positions of the vibration-induced pulses. It is demonstrated that when the width and peak power of input optical pulse are set to 1 μs and 35 mW, respectively, the position error is less than ± 0.5 m in a sensing range of more than 16 km, with the spatial resolution of ~110 m.

Target analyte quantification by isotope dilution LC-MS/MS directly referring to internal standard concentrations--validation for serum cortisol measurement.

PubMed

Maier, Barbara; Vogeser, Michael

2013-04-01

Isotope dilution LC-MS/MS methods used in the clinical laboratory typically involve multi-point external calibration in each analytical series. Our aim was to test the hypothesis that determination of target analyte concentrations directly derived from the relation of the target analyte peak area to the peak area of a corresponding stable isotope labelled internal standard compound [direct isotope dilution analysis (DIDA)] may be not inferior to conventional external calibration with respect to accuracy and reproducibility. Quality control samples and human serum pools were analysed in a comparative validation protocol for cortisol as an exemplary analyte by LC-MS/MS. Accuracy and reproducibility were compared between quantification either involving a six-point external calibration function, or a result calculation merely based on peak area ratios of unlabelled and labelled analyte. Both quantification approaches resulted in similar accuracy and reproducibility. For specified analytes, reliable analyte quantification directly derived from the ratio of peak areas of labelled and unlabelled analyte without the need for a time consuming multi-point calibration series is possible. This DIDA approach is of considerable practical importance for the application of LC-MS/MS in the clinical laboratory where short turnaround times often have high priority.

Experimental Investigation of a Multiplex Fuel Injector Module With Discrete Jet Swirlers for Low Emission Combustors

NASA Technical Reports Server (NTRS)

Tacina, Robert; Mao, Chien-Pei; Wey, Changlie

2004-01-01

A low-NOx emissions combustor concept has been demonstrated in flame-tube tests. A lean-direct injection (LDI) concept was used where the fuel is injected directly into the flame zone and the overall equivalence ratio of the mixture is lean. The LDI concept described in this report is a multiplex fuel injector module containing multipoint fuel injection tips and multi-burning zones. The injector module comprises 25 equally spaced injection tips within a 76 by 76 mm area that fits into the flame-tube duct. The air swirlers were made from a concave plate on the axis of the fuel injector using drilled holes at an angle to the axis of the fuel injector. The NOx levels were quite low and are greater than 70 percent lower than the 1996 ICAO standard. At an inlet temperature of 810 K, inlet pressure of 2760 kPa, pressure drop of 4 percent and a flame temperature of 1900 K with JP8 fuel, the NOx emission index was 9. The 25-point injector module exhibited the most uniform radial distribution of fuel-air mixture and NOx emissions in the flame tube when compared to other multipoint injection devices. A correlation is developed relating the NOx emissions to inlet temperature, inlet pressure, equivalence ratio and pressure drop.

Thermal analysis in the rat glioma model during directly multipoint injection hyperthermia incorporating magnetic nanoparticles.

PubMed

Liu, Lianke; Ni, Fang; Zhang, Jianchao; Wang, Chunyu; Lu, Xiang; Guo, Zhirui; Yao, Shaowei; Shu, Yongqian; Xu, Ruizhi

2011-12-01

Hyperthermia incorporating magnetic nanoparticles (MNPs) is a hopeful therapy to cancers and steps into clinical tests at present. However, the clinical plan of MNPs deposition in tumors, especially applied for directly multipoint injection hyperthermia (DMIH), and the information of temperature rise in tumors by DMIH is lack of studied. In this paper, we mainly discussed thermal distributions induced by MNPs in the rat brain tumors during DMIH. Due to limited experimental measurement for detecting thermal dose of tumors, and in order to acquire optimized results of temperature distributions clinically needed, we designed the thermal model in which three types of MNPs injection for hyperthermia treatments were simulated. The simulated results showed that MNPs injection plan played an important role in determining thermal distribution, as well as the overall dose of MNPs injected. We found that as injected points enhanced, the difference of temperature in the whole tumor volume decreased. Moreover, from temperature detecting data by Fiber Optic Temperature Sensors (FOTSs) in glioma bearing rats during MNPs hyperthermia, we found the temperature errors by FOTSs reduced as the number of points injected enhanced. Finally, the results showed that the simulations are preferable and the optimized plans of the numbers and spatial positions of MNPs points injected are essential during direct injection hyperthermia.

47 CFR 54.806 - Calculation by the Administrator of interstate access universal service support for areas served...

Code of Federal Regulations, 2010 CFR

2010-10-01

... access universal service support for areas served by price cap local exchange carriers. 54.806 Section 54... Administrator of interstate access universal service support for areas served by price cap local exchange... calculate the Interstate Access Universal Service Support for areas served by price cap local exchange...

Is it feasible to pool funds for local children's services in England? Evidence from the national evaluation of children's trust pathfinders.

PubMed

Lorgelly, Paula; Bachmann, Max; Shreeve, Ann; Reading, Richard; Thorburn, June; Mugford, Miranda; O'Brien, Margaret; Husbands, Chris

2009-01-01

To describe how funds were pooled or otherwise jointly managed by National Health Service (NHS) primary care trusts and local authorities in England. To compare expenditure on local children's services by health, education and social services. We conducted a questionnaire survey of all 35 children's trust pathfinders, six months after they were launched, with a follow-up at 2.5 years. We also undertook an in-depth analysis of local authorities and primary care trusts, within eight pathfinder areas and three non-pathfinder areas, whereby we compared expenditure on children's services, interviewed managers and professionals and examined financial documents. Local authorities and NHS trusts coordinated expenditure in various ways, most commonly through informal agreements and aligning budgets but also by formally pooling budgets. The latter were usually for selected services such as child and adolescent mental health services, though four children's trusts pathfinders pooled (or aligned) their budgets for all children's services. Total expenditure per child was greatest for education, lowest for social services and intermediate for health. However, it was difficult to quantify education expenditure on children with health and social care needs, and health care expenditure on children. Sharing money for local children's services requires shared objectives, trust, and legal and accounting expertise. Several different mechanisms are permitted and many are feasible but programme budgeting for children's services could make them more effective.

A Local Government Services Program

ERIC Educational Resources Information Center

Jacobs, Bruce

1975-01-01

The Local Government Services Program, a cooperative venture of Ferris State College and six community colleges in northern Michigan, is providing local government leaders with a wide range of educational and practical problem solving services. Students and faculty conduct seminars, workshops, and training programs; they also provide consultation…

47 CFR 51.903 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... equivalent of the incumbent local exchange carrier access service provided by a non-incumbent local exchange... or other customer provided by an incumbent local exchange carrier or any functional equivalent of the incumbent local exchange carrier access service provided by a non-incumbent local exchange carrier...

47 CFR 51.903 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... equivalent of the incumbent local exchange carrier access service provided by a non-incumbent local exchange... or other customer provided by an incumbent local exchange carrier or any functional equivalent of the incumbent local exchange carrier access service provided by a non-incumbent local exchange carrier...

47 CFR 51.903 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... equivalent of the incumbent local exchange carrier access service provided by a non-incumbent local exchange... or other customer provided by an incumbent local exchange carrier or any functional equivalent of the incumbent local exchange carrier access service provided by a non-incumbent local exchange carrier...

20 CFR 661.310 - Under what limited conditions may a Local Board directly be a provider of core services...

Code of Federal Regulations, 2011 CFR

2011-04-01

... Board directly be a provider of core services, intensive services, or training services, or act as a One... Board directly be a provider of core services, intensive services, or training services, or act as a One-Stop Operator? (a) A Local Board may not directly provide core services, or intensive services, or be...

20 CFR 661.310 - Under what limited conditions may a Local Board directly be a provider of core services...

Code of Federal Regulations, 2010 CFR

2010-04-01

... Board directly be a provider of core services, intensive services, or training services, or act as a One... Board directly be a provider of core services, intensive services, or training services, or act as a One-Stop Operator? (a) A Local Board may not directly provide core services, or intensive services, or be...

Obtaining Related Services through Local Interagency Collaboration.

ERIC Educational Resources Information Center

Olsen, Kenneth R.

Designed as a resource for local school administrators, the report describes the experiences of 15 local special education agencies in providing related services at reasonable cost through interagency cooperation. An introductory chapter discusses the role of interagency committees (both policy and direct service types), and provides information…

32 CFR 1605.52 - Composition of local boards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Composition of local boards. 1605.52 Section... SELECTIVE SERVICE SYSTEM ORGANIZATION Local Boards § 1605.52 Composition of local boards. The Director of Selective Service shall prescribe the number of members of local boards. ...

32 CFR 1605.52 - Composition of local boards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Composition of local boards. 1605.52 Section... SELECTIVE SERVICE SYSTEM ORGANIZATION Local Boards § 1605.52 Composition of local boards. The Director of Selective Service shall prescribe the number of members of local boards. ...

Delivery of video-on-demand services using local storages within passive optical networks.

PubMed

Abeywickrama, Sandu; Wong, Elaine

2013-01-28

At present, distributed storage systems have been widely studied to alleviate Internet traffic build-up caused by high-bandwidth, on-demand applications. Distributed storage arrays located locally within the passive optical network were previously proposed to deliver Video-on-Demand services. As an added feature, a popularity-aware caching algorithm was also proposed to dynamically maintain the most popular videos in the storage arrays of such local storages. In this paper, we present a new dynamic bandwidth allocation algorithm to improve Video-on-Demand services over passive optical networks using local storages. The algorithm exploits the use of standard control packets to reduce the time taken for the initial request communication between the customer and the central office, and to maintain the set of popular movies in the local storage. We conduct packet level simulations to perform a comparative analysis of the Quality-of-Service attributes between two passive optical networks, namely the conventional passive optical network and one that is equipped with a local storage. Results from our analysis highlight that strategic placement of a local storage inside the network enables the services to be delivered with improved Quality-of-Service to the customer. We further formulate power consumption models of both architectures to examine the trade-off between enhanced Quality-of-Service performance versus the increased power requirement from implementing a local storage within the network.

Factors associated with travel to non-local genitourinary medicine clinics for gonorrhoea: an analysis of patients diagnosed in London, 2009-10.

PubMed

Le Polain de Waroux, Olivier; Hughes, Gwenda; Maguire, Helen; Crook, Paul D

2014-03-01

We analysed factors associated with travelling to non-local genitourinary medicine clinics for gonorrhoea care in London. We used surveillance data on London residents attending genitourinary medicine clinics in 2009-10 and calculated distances between patients' areas of residence and both the nearest genitourinary medicine clinic and the clinic attended. Non-local clinics were attended by 5408 (46.7%) patients. Men having sex with men attended non-local services more than heterosexuals (OR 3.83, p < 0.001). Among heterosexual men, black Africans and black Caribbeans were more likely, and South Asians less likely, to attend non-local services compared to whites (OR [95%CI] 1.33 [1.04-1.72], 1.36 [1.11-1.67] and 0.46 [0.31-0.70] respectively). Similar associations, although not statistically significant, were found in women. People were more likely to attend local services if their local clinic provided walk-in and young people's services, weekend consultations and long opening hours. These findings could help design services meeting local population needs and facilitate prompt and equitable access to care.

47 CFR 54.802 - Obligations of local exchange carriers and the Administrator.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false Obligations of local exchange carriers and the Administrator. 54.802 Section 54.802 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) UNIVERSAL SERVICE Interstate Access Universal Service Support Mechanism § 54.802 Obligations of local exchange...

41 CFR 60-250.84 - Responsibilities of local employment service offices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Responsibilities of local employment service offices. 60-250.84 Section 60-250.84 Public Contracts and Property Management Other... OTHER PROTECTED VETERANS Ancillary Matters § 60-250.84 Responsibilities of local employment service...

41 CFR 60-250.84 - Responsibilities of local employment service offices.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Responsibilities of local employment service offices. 60-250.84 Section 60-250.84 Public Contracts and Property Management Other... OTHER PROTECTED VETERANS Ancillary Matters § 60-250.84 Responsibilities of local employment service...

41 CFR 60-250.84 - Responsibilities of local employment service offices.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Responsibilities of local employment service offices. 60-250.84 Section 60-250.84 Public Contracts and Property Management Other... OTHER PROTECTED VETERANS Ancillary Matters § 60-250.84 Responsibilities of local employment service...

Freestream Effects on Boundary Layer Disturbances for HIFiRE-5 (Postprint)

DTIC Science & Technology

2015-01-01

hypersonic wind tunnel . For Mach 6.5 and 7, there was no evidence of traveling crossflow waves . However, higher-frequency disturbances were observed. These...disturbances. The structure of these disturbances (phase velocity and wave angle) is similar in both wind tunnels . Coherence measurements in the ACE show that...These include detailed mapping of disturbance fields in the wind tunnel , including higher-frequency measurements, multi-point probe mea- surements to

ICU Multipoint Military Pacific Consultation using Telehealth (IMMPACT)

DTIC Science & Technology

2010-05-01

the Leapfrog Group has found that mortality rates are up to 30 percent lower and lengths of stay ( LOS ) up to three days shorter in ICUs managed by...length of stay ( LOS ), the two key outcome measures for ICUs. Some hospitals report clinical improvements such as higher rates of survival from...compares patient outcomes before and after the installation of the Tele-ICU.5 Sentara found that mortality, LOS , and financial measures all improved

Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fain, P.R.; Barker, D.F.; Chance, P.F.

1994-02-01

Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X Chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56, PGK1). 38 refs., 2 figs., 1 tab.

The work of local healthcare innovation: a qualitative study of GP-led integrated diabetes care in primary health care.

PubMed

Foster, Michele; Burridge, Letitia; Donald, Maria; Zhang, Jianzhen; Jackson, Claire

2016-01-14

Service delivery innovation is at the heart of efforts to combat the growing burden of chronic disease and escalating healthcare expenditure. Small-scale, locally-led service delivery innovation is a valuable source of learning about the complexities of change and the actions of local change agents. This exploratory qualitative study captures the perspectives of clinicians and managers involved in a general practitioner-led integrated diabetes care innovation. Data on these change agents' perspectives on the local innovation and how it works in the local context were collected through focus groups and semi-structured interviews at two primary health care sites. Transcribed data were analysed thematically. Normalization Process Theory provided a framework to explore perspectives on the individual and collective work involved in putting the innovation into practice in local service delivery contexts. Twelve primary health care clinicians, hospital-based medical specialists and practice managers participated in the study, which represented the majority involved in the innovation at the two sites. The thematic analysis highlighted three main themes of local innovation work: 1) trusting and embedding new professional relationships; 2) synchronizing services and resources; and 3) reconciling realities of innovation work. As a whole, the findings show that while locally-led service delivery innovation is designed to respond to local problems, convincing others to trust change and managing the boundary tensions is core to local work, particularly when it challenges taken-for-granted practices and relationships. Despite this, the findings also show that local innovators can and do act in both discretionary and creative ways to progress the innovation. The use of Normalization Process Theory uncovered some critical professional, organizational and structural factors early in the progression of the innovation. The key to local service delivery innovation lies in building coalitions of trust at the point of service delivery and persuading organizational and institutional mindsets to consider the opportunities of locally-led innovation.

Local inpatient units may increase patients' utilization of outpatient services: a comparative cohort-study in Nordland County, Norway.

PubMed

Myklebust, Lars Henrik; Sørgaard, Knut; Wynn, Rolf

2015-01-01

In the last few decades, there has been a restructuring of the psychiatric services in many countries. The complexity of these systems may represent a challenge to patients that suffer from serious psychiatric disorders. We examined whether local integration of inpatient and outpatient services in contrast to centralized institutions strengthened continuity of care. Two different service-systems were compared. Service-utilization over a 4-year period for 690 inpatients was extracted from the patient registries. The results were controlled for demographic variables, model of service-system, central inpatient admission or local inpatient admission, diagnoses, and duration of inpatient stays. The majority of inpatients in the area with local integration of inpatient and outpatient services used both types of care. In the area that did not have beds locally, many patients that had been hospitalized did not receive outpatient follow-up. Predictors of inpatients' use of outpatient psychiatric care were: Model of service-system (centralized vs decentralized), a diagnosis of affective disorder, central inpatient admission only, and duration of inpatient stays. Psychiatric centers with local inpatient units may positively affect continuity of care for patients with severe psychiatric disorders, probably because of a high functional integration of inpatient and outpatient care.

Local inpatient units may increase patients’ utilization of outpatient services: a comparative cohort-study in Nordland County, Norway

PubMed Central

Myklebust, Lars Henrik; Sørgaard, Knut; Wynn, Rolf

2015-01-01

Objectives In the last few decades, there has been a restructuring of the psychiatric services in many countries. The complexity of these systems may represent a challenge to patients that suffer from serious psychiatric disorders. We examined whether local integration of inpatient and outpatient services in contrast to centralized institutions strengthened continuity of care. Methods Two different service-systems were compared. Service-utilization over a 4-year period for 690 inpatients was extracted from the patient registries. The results were controlled for demographic variables, model of service-system, central inpatient admission or local inpatient admission, diagnoses, and duration of inpatient stays. Results The majority of inpatients in the area with local integration of inpatient and outpatient services used both types of care. In the area that did not have beds locally, many patients that had been hospitalized did not receive outpatient follow-up. Predictors of inpatients’ use of outpatient psychiatric care were: Model of service-system (centralized vs decentralized), a diagnosis of affective disorder, central inpatient admission only, and duration of inpatient stays. Conclusion Psychiatric centers with local inpatient units may positively affect continuity of care for patients with severe psychiatric disorders, probably because of a high functional integration of inpatient and outpatient care. PMID:26604843

REGIONAL COORDINATION OF NOAA/NATIONAL WEATHER SERVICE CLIMATE SERVICES IN THE WEST (Invited)

NASA Astrophysics Data System (ADS)

Bair, A.

2009-12-01

The climate services program is an important component in the National Weather Service’s (NWS) mission, and is one of the National Oceanic and Atmospheric Administration’s (NOAA) top five priorities. The Western Region NWS started building a regional and local climate services program in late 2001, with input from local NWS offices and key partners. The original goals of the Western Region climate services program were to strive to provide climate services that were useful, easily accessible, well understood, coordinated and supported by partners, and reflect customer needs. While the program has evolved, and lessons have been learned, these goals are still guiding the program. Regional and local level Climate Services are a fundamental part of NOAA/NWS’s current and future role in providing climate services. There is an ever growing demand for climate information and services to aid the public in decision-making and no single entity alone can provide the range of information and services needed. Coordination and building strong partnerships at the local and regional levels is the key to providing optimal climate services. Over the past 8 years, Western Region NWS has embarked on numerous coordination efforts to build the regional and local climate services programs, such as: collaboration (both internally and externally to NOAA) meetings and projects, internal staff training, surveys, and outreach efforts. In order to gain regional and local buy-in from the NWS staff, multiple committees were utilized to plan and develop goals and structure for the program. While the regional and local climate services program in the NWS Western Region has had many successes, there have been several important lessons learned from efforts that have not been as successful. These lessons, along with past experience, close coordination with partners, and the need to constantly improve/change the program as the climate changes, form the basis for future program development and goals.

75 FR 17407 - Service Corporation International and Keystone North America Inc.; Analysis of Agreement...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-06

..., and environmental regulations impact significantly the ability of firms to enter with new cemetery... in 16 local funeral services markets and four cemeteries in three local cemetery services markets to... substantial competitor from 16 funeral services markets, and three cemetery services markets. The proposed...

Sustainability in Health care by Allocating Resources Effectively (SHARE) 7: supporting staff in evidence-based decision-making, implementation and evaluation in a local healthcare setting.

PubMed

Harris, Claire; Allen, Kelly; Waller, Cara; Dyer, Tim; Brooke, Vanessa; Garrubba, Marie; Melder, Angela; Voutier, Catherine; Gust, Anthony; Farjou, Dina

2017-06-21

This is the seventh in a series of papers reporting Sustainability in Health care by Allocating Resources Effectively (SHARE) in a local healthcare setting. The SHARE Program was a systematic, integrated, evidence-based program for resource allocation within a large Australian health service. It aimed to facilitate proactive use of evidence from research and local data; evidence-based decision-making for resource allocation including disinvestment; and development, implementation and evaluation of disinvestment projects. From the literature and responses of local stakeholders it was clear that provision of expertise and education, training and support of health service staff would be required to achieve these aims. Four support services were proposed. This paper is a detailed case report of the development, implementation and evaluation of a Data Service, Capacity Building Service and Project Support Service. An Evidence Service is reported separately. Literature reviews, surveys, interviews, consultation and workshops were used to capture and process the relevant information. Existing theoretical frameworks were adapted for evaluation and explication of processes and outcomes. Surveys and interviews identified current practice in use of evidence in decision-making, implementation and evaluation; staff needs for evidence-based practice; nature, type and availability of local health service data; and preferred formats for education and training. The Capacity Building and Project Support Services were successful in achieving short term objectives; but long term outcomes were not evaluated due to reduced funding. The Data Service was not implemented at all. Factors influencing the processes and outcomes are discussed. Health service staff need access to education, training, expertise and support to enable evidence-based decision-making and to implement and evaluate the changes arising from those decisions. Three support services were proposed based on research evidence and local findings. Local factors, some unanticipated and some unavoidable, were the main barriers to successful implementation. All three proposed support services hold promise as facilitators of EBP in the local healthcare setting. The findings from this study will inform further exploration.

Initial Thomson Scattering Survey of Local Helicity Injection and Ohmic Plasmas at the Pegasus Toroidal Experiment

NASA Astrophysics Data System (ADS)

Schlossberg, D. J.; Bodner, G. M.; Bongard, M. W.; Fonck, R. J.; Winz, G. R.

2014-10-01

A multipoint Thomson scattering diagnostic has recently been installed on the Pegasus ST. The system utilizes a frequency-doubled Nd:YAG laser (λ0 ~ 532 nm), spectrometers with volume phase holographic gratings, and a gated, intensified CCD camera. It provides measurements of Te and ne at 8 spatial locations for each spectrometer once per discharge. A new multiple aperture and beam dump system has been implemented to mitigate interference from stray light. This system has provided initial measurements in the core region of plasmas initiated by local helicity injection (LHI), as well as conventional Ohmic L- and H-mode discharges. Multi-shot averages of low-density (ne ~ 3 ×1018 m-3) , Ip ~ 0 . 1 MA LHI discharges show central Te ~ 75 eV at the end of the helicity injection phase. Ip ~ 0 . 13 MA Ohmic plasmas at moderate densities (ne ~ 2 ×1019 m-3) have core Te ~ 150 eV in L-mode. Generally, these plasmas do not reach transport equilibrium in the short 25 ms pulse length available. After an L-H transition, strong spectral broadening indicates increasing Te, to values above the range of the present spectrometer system with a high-dispersion VPH grating. Near-term system upgrades will focus on deploying a second spectrometer, with a lower-dispersion grating capable of measuring the 0.1-1.0 keV range. The second spectrometer system will also increase the available number of spatial channels, enabling study of H-mode pedestal structure. Work supported by US DOE Grant DE-FG02-96ER54375.

Nance-Horan syndrome: linkage analysis in 4 families refines localization in Xp22.31-p22.13 region.

PubMed

Toutain, A; Ronce, N; Dessay, B; Robb, L; Francannet, C; Le Merrer, M; Briard, M L; Kaplan, J; Moraine, C

1997-02-01

Nance-Horan syndrome (NHS) is an X-linked disease characterized by severe congenital cataract with microcornea, distinctive dental findings, evocative facial features and mental impairment in some cases. Previous linkage studies have placed the NHS gene in a large region from DXS143 (Xp22.31) to DXS451 (Xp22.13). To refine this localization further, we have performed linkage analysis in four families. As the maximum expected Lod score is reached in each family for several markers in the Xp22.31-p22.13 region and linkage to the rest of the X chromosome can be excluded, our study shows that NHS is a genetically homogeneous condition. An overall maximum two-point Lod score of 9.36 (theta = 0.00) is obtained with two closely linked markers taken together. DXS207 and DXS1053 in Xp22.2. Recombinant haplotypes indicate that the NHS gene lies between DXS85 and DXS1226. Multipoint analysis yield a maximum Lod score of 9.45 with the support interval spanning a 15-cM region that includes DXS16 and DXS1229/365. The deletion map of the Xp22.3-Xp21.3 region suggests that the phenotypic variability of NHS is not related to gross rearrangement of sequences of varying size but rather to allelic mutations in a single gene, presumably located proximal to DXS16 and distal to DXS1226. Comparison with the map position of the mouse Xcat mutation supports the location of the NHS gene between the GRPR and PDHA1 genes in Xp22.2.

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study

PubMed Central

Gribble, Matthew O.; Voruganti, Venkata Saroja; Cole, Shelley A.; Haack, Karin; Balakrishnan, Poojitha; Laston, Sandra L.; Tellez-Plaza, Maria; Francesconi, Kevin A.; Goessler, Walter; Umans, Jason G.; Thomas, Duncan C.; Gilliland, Frank; North, Kari E.; Franceschini, Nora; Navas-Acien, Ana

2015-01-01

Arsenic toxicokinetics are important for disease risks in exposed populations, but genetic determinants are not fully understood. We examined urine arsenic species patterns measured by HPLC-ICPMS among 2189 Strong Heart Study participants 18 years of age and older with data on ∼400 genome-wide microsatellite markers spaced ∼10 cM and arsenic speciation (683 participants from Arizona, 684 from Oklahoma, and 822 from North and South Dakota). We logit-transformed % arsenic species (% inorganic arsenic, %MMA, and %DMA) and also conducted principal component analyses of the logit % arsenic species. We used inverse-normalized residuals from multivariable-adjusted polygenic heritability analysis for multipoint variance components linkage analysis. We also examined the contribution of polymorphisms in the arsenic metabolism gene AS3MT via conditional linkage analysis. We localized a quantitative trait locus (QTL) on chromosome 10 (LOD 4.12 for %MMA, 4.65 for %DMA, and 4.84 for the first principal component of logit % arsenic species). This peak was partially but not fully explained by measured AS3MT variants. We also localized a QTL for the second principal component of logit % arsenic species on chromosome 5 (LOD 4.21) that was not evident from considering % arsenic species individually. Some other loci were suggestive or significant for 1 geographical area but not overall across all areas, indicating possible locus heterogeneity. This genome-wide linkage scan suggests genetic determinants of arsenic toxicokinetics to be identified by future fine-mapping, and illustrates the utility of principal component analysis as a novel approach that considers % arsenic species jointly. PMID:26209557

Gibbs sampling on large lattice with GMRF

NASA Astrophysics Data System (ADS)

Marcotte, Denis; Allard, Denis

2018-02-01

Gibbs sampling is routinely used to sample truncated Gaussian distributions. These distributions naturally occur when associating latent Gaussian fields to category fields obtained by discrete simulation methods like multipoint, sequential indicator simulation and object-based simulation. The latent Gaussians are often used in data assimilation and history matching algorithms. When the Gibbs sampling is applied on a large lattice, the computing cost can become prohibitive. The usual practice of using local neighborhoods is unsatisfying as it can diverge and it does not reproduce exactly the desired covariance. A better approach is to use Gaussian Markov Random Fields (GMRF) which enables to compute the conditional distributions at any point without having to compute and invert the full covariance matrix. As the GMRF is locally defined, it allows simultaneous updating of all points that do not share neighbors (coding sets). We propose a new simultaneous Gibbs updating strategy on coding sets that can be efficiently computed by convolution and applied with an acceptance/rejection method in the truncated case. We study empirically the speed of convergence, the effect of choice of boundary conditions, of the correlation range and of GMRF smoothness. We show that the convergence is slower in the Gaussian case on the torus than for the finite case studied in the literature. However, in the truncated Gaussian case, we show that short scale correlation is quickly restored and the conditioning categories at each lattice point imprint the long scale correlation. Hence our approach enables to realistically apply Gibbs sampling on large 2D or 3D lattice with the desired GMRF covariance.

Velocity Space Degrees of Freedom of Plasma Fluctuations

NASA Astrophysics Data System (ADS)

Mattingly, Sean

2017-10-01

Small scale wave modes are becoming more important in plasma physics. Examples include turbulent cascades in the solar wind, the energetics of fusion plasma electrostatic turbulence and transport, and low temperature basic plasma physics experiments. In order to improve our understanding of these modes, I present an advance in experimental plasma diagnostics and use it to show the first measurement of a plasma ion velocity-space cross-correlation matrix. From this matrix I determine the eigenmodes of fluctuations on the ion distribution function as a function of frequency. I also determine the relative strengths of these modes - these are the velocity space degrees of freedom of plasma fluctuations. This measurement can detect the aforementioned smaller scale modes in plasmas through a localized measurement. The locality of this measurement means that it may be applied to plasmas in which a single - point velocity sensitive diagnostic is available and multipoint measurements may be difficult. Examples include in situ measurements of space plasmas, fusion plasmas, trapped plasmas, and laser cooled plasmas. This fact, combined with the new perspective it can give on small scale plasma fluctuations, means it may be used to further research on the above cited subjects. Much work remains on fully understanding this measurement. This measurement opens a velocity space interpretation of small scale plasma wave modes, and understanding this perspective from theory requires the application or invention of new mathematical tools. I discuss open problems to follow up on, which include questions from experimental, theoretical, and instrumentation perspectives. NSF-DOE Program Grant DE-FG02-99ER54543.

Veff Scaling of Te and ne Measurements During Local Helicity Injection on the Pegasus Toroidal Experiment

NASA Astrophysics Data System (ADS)

Bodner, G. M.; Bongard, M. W.; Fonck, R. J.; Perry, J. M.; Reusch, J. A.; Rodriguez Sanchez, C.

2017-10-01

Understanding the electron confinement of local helicity injection (LHI) is critical in order to evaluate its scalability as a startup technique to MA-class devices. Electron confinement in the Pegasus Toroidal Experiment is investigated using multi-point Thomson scattering (TS). The Pegasus TS system utilizes a set of high-throughput transmission gratings and intensified CCDs to measure Te and ne profiles. Previous TS measurements indicated peaked Te profiles 120 eV in outboard injector discharges characterized by strong inductive drive and low LHI drive. Injectors designed to have dominant non-inductive drive have recently been installed in the divertor region of Pegasus to understand the relationship between effective drive voltage, Veff, and plasma performance. At low Veff and reduced plasma current, Ip 60 kA, TS measurements reveal a flat Te profile 50 eV, with a peaked ne profile 1 ×1019 m-3, resulting in a slightly peaked pe profile. As current drive is increased, the Te profiles become hollow with a core Te 50 eV and an edge Te 120 -150 eV. These hollow profiles appear after the start of the Ip flattop and are sustained until the discharge terminates. The ne profiles drop in magnitude to < 1 ×1019 m-3 but remain somewhat peaked. Initial results suggest a weak scaling between input power and core Te. Additional studies are planned to identify the mechanisms behind the anomalous profile features. Work supported by US DOE Grant DE-FG02-96ER54375.

42 CFR 494.20 - Condition: Compliance with Federal, State, and local laws and regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... local laws and regulations. 494.20 Section 494.20 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION CONDITIONS FOR COVERAGE FOR..., State, and local laws and regulations. The facility and its staff must operate and furnish services in...

20 CFR 653.101 - Provision of services to migrant and seasonal farmworkers (MSFWs).

Code of Federal Regulations, 2011 CFR

2011-04-01

... local offices, including itinerant and satellite offices, but exclusive of day-haul operations, offer services to both non-MSFWs and MSFWs. Separate farm labor service local offices, which offer only farmwork... agency and each local office shall offer to migrant and seasonal farmworkers (MSFWs) the full range of...

The Impact of Local Environmental Health Capacity on Foodborne Illness Morbidity in Maryland

PubMed Central

Resnick, Beth A.; Fox, Mary A.; McGready, John; Yager, James P.; Burke, Thomas A.

2011-01-01

Objectives. We evaluated the relationship between local food protection capacity and service provision in Maryland's 24 local food protection programs (FPPs) and incidence of foodborne illness at the county level. Methods. We conducted regression analyses to determine the relationship between foodborne illness and local FPP characteristics. We used the Centers for Disease Control and Prevention's FoodNet and Maryland Department of Health and Mental Hygiene outbreak data set, along with data on Maryland's local FPP capacity (workforce size and experience levels, budget) and service provision (food service facility inspections, public notification programs). Results. Counties with higher capacity, such as larger workforce, higher budget, and greater employee experience, had fewer foodborne illnesses. Counties with better performance and county-level regulations, such as high food service facility inspection rates and requiring certified food manager programs, respectively, had lower rates of illness. Conclusions. Counties with strong local food protection capacity and services can protect the public from foodborne illness. Research on public health services can enhance our understanding of the food protection infrastructure, and the effectiveness of food protection programs in preventing foodborne illness. PMID:21750282

Electrode-Skin contact impedance: In vivo measurements on an ovine model

NASA Astrophysics Data System (ADS)

Nguyen, D. T.; Kosobrodov, R.; Barry, M. A.; Chik, W.; Jin, C.; Oh, T. I.; Thiagalingam, A.; McEwan, A.

2013-04-01

The problem of electrical impedance between the skin and the electrode is an on-going challenge in bio-electronics. This is particularly true in the case of Electrical Impedance Tomography (EIT), which uses a large number of skin-contact electrodes and is very sensitive to noise. In the present article, contact impedance is measured and compared for a range of electrodes placed on the thorax of an ovine model. The study has been approved by the Westmead Hospital Animal Ethics Committee. The electrode models that were employed in the research are Ag/AgCl electrodes (E1), commonly used for ECG and EIT measurements in both humans and animal models, stainless steel crocodile clips (E2), typically used on animal models, and novel multi-point dry electrodes in two modifications: bronze plated (E3) and nickel plated (E4). Further, since the contact impedance is mostly attributed to the acellular outer layer of the skin, in our experiment, we attempted to study the effect of this layer by comparing the results when the skin is intact and when electrodes are introduced underneath the skin through small cuts. This boundary effect was assessed by comparison of measurements obtained during E2 skin surface contact, and sub-cutaneous contact (E5). Twelve gauge intradermal needles were also tested as an electrode (E6). The full impedance spectrum, from 500 Hz to 300 kHz, was recorded, analysed and compared. As expected, the contact impedance in the more invasive cases, i.e the electrodes under the skin, is significantly lower than in the non-invasive cases. At the frequency of 50 kHz which is commonly used in lung EIT acquisition, electrodes E3, E4 and E6 demonstrated contact impedance of less than 200 Ω, compared to more than 400 Ω measured for electrodes E1, E2 and E5. In conclusion, the novel multipoint electrodes proved to be best suited for EIT purposes, because they are non-invasive and have lower contact impedance than Ag/AgCl and crocodile clips, in both invasive and non-invasive cases. This further prompted us to design a flexible electrode belt using the novel multi-point electrodes for lung EIT on animal models.

Identity Management and Trust Services: Foundations for Cloud Computing

ERIC Educational Resources Information Center

Suess, Jack; Morooney, Kevin

2009-01-01

Increasingly, IT organizations will move from providing IT services locally to becoming an integrator of IT services--some provided locally and others provided outside the institution. As a result, institutions must immediately begin to plan for shared services and must understand the essential role that identity management and trust services play…

Building social capital with interprofessional student teams in rural settings: A service-learning model.

PubMed

Craig, Pippa L; Phillips, Christine; Hall, Sally

2016-08-01

To describe outcomes of a model of service learning in interprofessional learning (IPL) aimed at developing a sustainable model of training that also contributed to service strengthening. A total of 57 semi-structured interviews with key informants and document review exploring the impacts of interprofessional student teams engaged in locally relevant IPL activities. Six rural towns in South East New South Wales. Local facilitators, staff of local health and other services, health professionals who supervised the 89 students in 37 IPL teams, and academic and administrative staff. Perceived benefits as a consequence of interprofessional, service-learning interventions in these rural towns. Reported outcomes included increased local awareness of a particular issue addressed by the team; improved communication between different health professions; continued use of the team's product or a changed procedure in response to the teams' work; and evidence of improved use of a particular local health service. Given the limited workforce available in rural areas to supervise clinical IPL placements, a service-learning IPL model that aims to build social capital may be a useful educational model. © 2015 National Rural Health Alliance Inc.

20 CFR 230.5 - Exception concerning service to a local lodge or division.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Exception concerning service to a local lodge... to a local lodge or division. In determining whether an annuity is subject to the provisions of this... lodge or division of a railway-labor-organization employer if the compensation for such service is...

Systematic Search for Gene-Gene Interaction Effect on Prostate Cancer Risk

DTIC Science & Technology

2012-07-01

U b . ABSTRACT U c. THIS PAGE U UU 26 19b. TELEPHONE NUMBER (include area code) Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std...Marchini, J., Howie, B ., Myers, S., McVean, G. and Donnelly, P. (2007) A new multipoint method for genome-wide association studies by imputation of...Benediktsdottir, K.R., Cazier, J.B., Sainz, J., Jakobsdottir, M., Kostic, J., Magnusdottir, D.N., Ghosh, S., Agnarsson, K., Birgisdottir, B ., Le Roux, L

Deformations of thick two-material cylinder under axially varying radial pressure

NASA Technical Reports Server (NTRS)

Patel, Y. A.

1976-01-01

Stresses and deformations in thick, short, composite cylinder subjected to axially varying radial pressure are studied. Effect of slippage at the interface is examined. In the NASTRAN finite element model, multipoint constraint feature is utilized. Results are compared with theoretical analysis and SAP-IV computer code. Results from NASTRAN computer code are in good agreement with the analytical solutions. Results suggest a considerable influence of interfacial slippage on the axial bending stresses in the cylinder.

KSC-06pd0262

NASA Image and Video Library

2005-12-27

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences Building 1555 at Vandenberg Air Force Base in California, a worker underneath the tail of the Pegasus XL rocket completes installation of the fin. The Pegasus will launch the Space Technology 5 spacecraft later this month. ST5 contains three micro-satellites that will be positioned in a "string of pearls" constellation to perform simultaneous multi-point measurements of the Earth's magnetic field using highly sensitive magnetometers. The scheduled launch date is Feb. 28.

KSC-06pd0261

NASA Image and Video Library

2005-12-27

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences Building 1555 at Vandenberg Air Force Base in California, a worker installs one of the fins on the aft skirt of the Pegasus XL rocket that will launch the Space Technology 5 spacecraft later this month. ST5 contains three micro-satellites that will be positioned in a "string of pearls" constellation to perform simultaneous multi-point measurements of the Earth's magnetic field using highly sensitive magnetometers. The scheduled launch date is Feb. 28.

KSC-06pd0258

NASA Image and Video Library

2005-12-27

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences Building 1555 at Vandenberg Air Force Base in California, workers move the aft skirt toward the Pegasus XL launch vehicle for mating. The Pegasus will launch the Space Technology 5 spacecraft later this month. ST5 contains three micro-satellites that will be positioned in a "string of pearls" constellation to perform simultaneous multi-point measurements of the Earth's magnetic field using highly sensitive magnetometers. The scheduled launch date is Feb. 28.

Suitability Evaluation of Multipoint Simultaneous CO2 Sampling Wireless Sensors for Livestock Buildings

PubMed Central

Calvet, Salvador; Campelo, José Carlos; Estellés, Fernando; Perles, Angel; Mercado, Ricardo; Serrano, Juan José

2014-01-01

The environment in livestock buildings must be controlled to ensure the health and welfare of both workers and animals, as well as to restrict the emission of pollutants to the atmosphere. Among the pollutants generated inside these premises, carbon dioxide (CO2) is of great interest in terms of animal welfare and ventilation control. The use of inexpensive sensors means that complete systems can be designed with a number of sensors located around the building. This paper describes a study of the suitability of multipoint simultaneous CO2 sensors operating in a wireless sensor network, which was found to operate satisfactorily under laboratory conditions and was found to be the best alternative for these applications. The sensors showed a highly linear response to CO2 concentrations, ranging from 500 to 5000 ppm. However, individual sensor response was found to differ, which made it necessary to calibrate each one separately. Sensor precision ranged between 80 and 110 ppm CO2, and sensor response to register a 95% change in concentration was estimated at around 5 min. These features mean this type of sensor network can be used to monitor animal welfare and also for environmental control in poorly ventilated livestock premises. According to the tests conducted in this study, a temporal drift may occur and therefore a regular calibration of sensors would be needed. PMID:24932867

A Novel RFID-Based Sensing Method for Low-Cost Bolt Loosening Monitoring.

PubMed

Wu, Jian; Cui, Xingmei; Xu, Yunpeng

2016-01-28

In coal mines, bolt loosening in the cage guide is affected by the harsh environmental factors and cage hoist vibration, leading to significant threats to work safety. It is crucial, to this effect, to successfully detect the status of multipoint bolts of guide structures. This paper proposes a system to monitor bolt status in harsh environments established based on the RFID technique. A proof-of-concept model was demonstrated consisting of a bolt gearing system, passive UHF RFID tags, a reader, and monitoring software. A tinfoil metal film is fixed on the retaining plate and an RFID tag bonded to a large gear, with the bolt to be detected fixed in the center of a smaller gear. The radio-frequency signal cannot be received by the reader if the tag is completely obscured by the tinfoil, and if the bolt is loose, the tag's antenna is exposed when the gear revolves. A radio-frequency signal that carries corresponding bolt's information is transmitted by the RFID tag to the RFID reader due to coil coupling, identifying loose bolt location and reporting them in the software. Confirmatory test results revealed that the system indeed successfully detects bolt loosening and comparative test results (based on a reed switch multipoint bolt loosening monitor system) provided valuable information regarding the strengths and weaknesses of the proposed system.

NOx Emissions Performance and Correlation Equations for a Multipoint LDI Injector

NASA Technical Reports Server (NTRS)

He, Zhuohui J.; Chang, Clarence T.; Follen, Caitlin E.

2014-01-01

Lean Direct Injection (LDI) is a combustor concept that reduces nitrogen oxides (NOx) emissions. This paper looks at a 3-zone multipoint LDI concept developed by Parker Hannifin Corporation. The concept was tested in a flame-tube test facility at NASA Glenn Research Center. Due to test facility limitations, such as inlet air temperature and pressure, the flame-tube test was not able to cover the full set of engine operation conditions. Three NOx correlation equations were developed based on assessing NOx emissions dependencies on inlet air pressure (P3), inlet air temperature (T3), and fuel air equivalence ratio (phi) to estimate the NOx emissions at the unreachable high engine power conditions. As the results, the NOx emissions are found to be a strong function of combustion inlet air temperature and fuel air equivalence ratio but a weaker function of inlet air pressure. With these three equations, the NOx emissions performance of this injector concept is calculated as a 66 percent reduction relative to the ICAO CAEP-6 standard using a 55:1 pressure-ratio engine cycle. Uncertainty in the NOx emissions estimation increases as the extrapolation range departs from the experimental conditions. Since maximum inlet air pressure tested was less than 50 percent of the full power engine inlet air pressure, a future experiment at higher inlet air pressure conditions is needed to confirm the NOx emissions dependency on inlet air pressure.

Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorder.

PubMed

Service, Susan; Molina, Julio; Deyoung, Joseph; Jawaheer, Damini; Aldana, Ileana; Vu, Thuy; Araya, Carmen; Araya, Xinia; Bejarano, Julio; Fournier, Eduardo; Ramirez, Magui; Mathews, Carol A; Davanzo, Pablo; Macaya, Gabriel; Sandkuijl, Lodewijk; Sabatti, Chiara; Reus, Victor; Freimer, Nelson

2006-06-05

We have ascertained in the Central Valley of Costa Rica a new kindred (CR201) segregating for severe bipolar disorder (BP-I). The family was identified by tracing genealogical connections among eight persons initially independently ascertained for a genome wide association study of BP-I. For the genome screen in CR201, we trimmed the family down to 168 persons (82 of whom are genotyped), containing 25 individuals with a best-estimate diagnosis of BP-I. A total of 4,690 SNP markers were genotyped. Analysis of the data was hampered by the size and complexity of the pedigree, which prohibited using exact multipoint methods on the entire kindred. Two-point parametric linkage analysis, using a conservative model of transmission, produced a maximum LOD score of 2.78 on chromosome 6, and a total of 39 loci with LOD scores >1.0. Multipoint parametric and non-parametric linkage analysis was performed separately on four sections of CR201, and interesting (nominal P-value from either analysis <0.01), although not statistically significant, regions were highlighted on chromosomes 1, 2, 3, 12, 16, 19, and 22, in at least one section of the pedigree, or when considering all sections together. The difficulties of analyzing genome wide SNP data for complex disorders in large, potentially informative, kindreds are discussed.

A Novel RFID-Based Sensing Method for Low-Cost Bolt Loosening Monitoring

PubMed Central

Wu, Jian; Cui, Xingmei; Xu, Yunpeng

2016-01-01

In coal mines, bolt loosening in the cage guide is affected by the harsh environmental factors and cage hoist vibration, leading to significant threats to work safety. It is crucial, to this effect, to successfully detect the status of multipoint bolts of guide structures. This paper proposes a system to monitor bolt status in harsh environments established based on the RFID technique. A proof-of-concept model was demonstrated consisting of a bolt gearing system, passive UHF RFID tags, a reader, and monitoring software. A tinfoil metal film is fixed on the retaining plate and an RFID tag bonded to a large gear, with the bolt to be detected fixed in the center of a smaller gear. The radio-frequency signal cannot be received by the reader if the tag is completely obscured by the tinfoil, and if the bolt is loose, the tag’s antenna is exposed when the gear revolves. A radio-frequency signal that carries corresponding bolt’s information is transmitted by the RFID tag to the RFID reader due to coil coupling, identifying loose bolt location and reporting them in the software. Confirmatory test results revealed that the system indeed successfully detects bolt loosening and comparative test results (based on a reed switch multipoint bolt loosening monitor system) provided valuable information regarding the strengths and weaknesses of the proposed system. PMID:26828498

Lod scores for gene mapping in the presence of marker map uncertainty.

PubMed

Stringham, H M; Boehnke, M

2001-07-01

Multipoint lod scores are typically calculated for a grid of locus positions, moving the putative disease locus across a fixed map of genetic markers. Changing the order of a set of markers and/or the distances between the markers can make a substantial difference in the resulting lod score curve and the location and height of its maximum. The typical approach of using the best maximum likelihood marker map is not easily justified if other marker orders are nearly as likely and give substantially different lod score curves. To deal with this problem, we propose three weighted multipoint lod score statistics that make use of information from all plausible marker orders. In each of these statistics, the information conditional on a particular marker order is included in a weighted sum, with weight equal to the posterior probability of that order. We evaluate the type 1 error rate and power of these three statistics on the basis of results from simulated data, and compare these results to those obtained using the best maximum likelihood map and the map with the true marker order. We find that the lod score based on a weighted sum of maximum likelihoods improves on using only the best maximum likelihood map, having a type 1 error rate and power closest to that of using the true marker order in the simulation scenarios we considered. Copyright 2001 Wiley-Liss, Inc.

Rogue waves in terms of multi-point statistics and nonequilibrium thermodynamics

NASA Astrophysics Data System (ADS)

Hadjihosseini, Ali; Lind, Pedro; Mori, Nobuhito; Hoffmann, Norbert P.; Peinke, Joachim

2017-04-01

Ocean waves, which lead to rogue waves, are investigated on the background of complex systems. In contrast to deterministic approaches based on the nonlinear Schroedinger equation or focusing effects, we analyze this system in terms of a noisy stochastic system. In particular we present a statistical method that maps the complexity of multi-point data into the statistics of hierarchically ordered height increments for different time scales. We show that the stochastic cascade process with Markov properties is governed by a Fokker-Planck equation. Conditional probabilities as well as the Fokker-Planck equation itself can be estimated directly from the available observational data. This stochastic description enables us to show several new aspects of wave states. Surrogate data sets can in turn be generated allowing to work out different statistical features of the complex sea state in general and extreme rogue wave events in particular. The results also open up new perspectives for forecasting the occurrence probability of extreme rogue wave events, and even for forecasting the occurrence of individual rogue waves based on precursory dynamics. As a new outlook the ocean wave states will be considered in terms of nonequilibrium thermodynamics, for which the entropy production of different wave heights will be considered. We show evidence that rogue waves are characterized by negative entropy production. The statistics of the entropy production can be used to distinguish different wave states.

Numerical Study of Pressure Fluctuations due to High-Speed Turbulent Boundary Layers

NASA Technical Reports Server (NTRS)

Duan, Lian; Choudhari, Meelan M.; Wu, Minwei

2012-01-01

Direct numerical simulations (DNS) are used to examine the pressure fluctuations generated by fully developed turbulence in supersonic turbulent boundary layers with an emphasis on both pressure fluctuations at the wall and the acoustic fluctuations radiated into the freestream. The wall and freestream pressure fields are first analyzed for a zero pressure gradient boundary layer with Mach 2.5 and Reynolds number based on momentum thickness of approximately 2835. The single and multi-point statistics reported include the wall pressure fluctuation intensities, frequency spectra, space-time correlations, and convection velocities. Single and multi-point statistics of surface pressure fluctuations show good agreement with measured data and previously published simulations of turbulent boundary layers under similar flow conditions. Spectral analysis shows that the acoustic fluctuations outside the boundary layer region have much lower energy content within the high-frequency region. The space-time correlations reflect the convective nature of the pressure field both at the wall and in the freestream, which is characterized by the downstream propagation of pressure-carrying eddies. Relative to those at the wall, the pressure-carrying eddies associated with the freestream signal are larger and convect at a significantly lower speed. The preliminary DNS results of a Mach 6 boundary layer show that the pressure rms in the freestream region is significantly higher than that of the lower Mach number case.

The application of a shift theorem analysis technique to multipoint measurements

NASA Astrophysics Data System (ADS)

Dieckmann, M. E.; Chapman, S. C.

1999-03-01

A Fourier domain technique has been proposed previously which, in principle, quantifies the extent to which multipoint in-situ measurements can identify whether or not an observed structure is time stationary in its rest frame. Once a structure, sampled for example by four spacecraft, is shown to be quasi-stationary in its rest frame, the structure's velocity vector can be determined with respect to the sampling spacecraft. We investigate the properties of this technique, which we will refer to as a stationarity test, by applying it to two point measurements of a simulated boundary layer. The boundary layer was evolved using a PIC (particle in cell) electromagnetic code. Initial and boundary conditions were chosen such, that two cases could be considered, i.e. a spacecraft pair moving through (1) a time stationary boundary structure and (2) a boundary structure which is evolving (expanding) in time. The code also introduces noise in the simulated data time series which is uncorrelated between the two spacecraft. We demonstrate that, provided that the time series is Hanning windowed, the test is effective in determining the relative velocity between the boundary layer and spacecraft and in determining the range of frequencies over which the data can be treated as time stationary or time evolving. This work presents a first step towards understanding the effectiveness of this technique, as required in order for it to be applied to multispacecraft data.

NOx Emissions Performance and Correlation Equations for a Multipoint LDI Injector

NASA Technical Reports Server (NTRS)

He, Zhuohui Joe; Chang, Clarence T.; Follen, Caitlin E.

2015-01-01

Lean Direct Injection (LDI) is a combustor concept that reduces nitrogen oxides (NOx) emissions.This paper looks at a 3-zone multipoint LDI concept developed by Parker Hannifin Corporation. The concept was tested in a flame-tube test facility at NASA Glenn Research Center. Due to test facility limitations, such as inlet air temperature and pressure, the flame-tube test was not able to cover the full set of engine operation conditions. Three NOx correlation equations were developed based on assessing NOx emissions dependencies on inlet air pressure (P3), inlet air temperature (T3), and fuel air equivalence ratio(theta) to estimate the NOx emissions at the unreachable high engine power conditions. As the results, the NOx emissions are found to be a strong function of combustion inlet air temperature and fuel air equivalence ratio but a weaker function of inlet air pressure. With these three equations, the NOx emissions performance of this injector concept is calculated as a 66 reduction relative to the ICAO CAEP-6 standard using a 55:1 pressure-ratio engine cycle. Uncertainty in the NOx emissions estimation increases as the extrapolation range departs from the experimental conditions. Since maximum inlet air pressure tested was less than 50 of the full power engine inlet air pressure, a future experiment at higher inlet air pressure conditions is needed to confirm the NOx emissions dependency on inlet air pressure.

NOx Emissions Performance and Correlation Equations for a Multipoint LDI Injector

NASA Technical Reports Server (NTRS)

He, Zhuohui J.; Chang, Clarence T.; Follen, Caitlin E.

2015-01-01

Lean Direct Injection (LDI) is a combustor concept that reduces nitrogen oxides (NOx) emissions. This paper looks at a 3-zone multipoint LDI concept developed by Parker Hannifin Corporation. The concept was tested in a flame-tube test facility at NASA Glenn Research Center. Due to test facility limitations, such as inlet air temperature and pressure, the flame-tube test was not able to cover the full set of engine operation conditions. Three NOx correlation equations were developed based on assessing NOx emissions dependencies on inlet air pressure (P3), inlet air temperature (T3), and fuel air equivalence ratio (?) to estimate the NOx emissions at the unreachable high engine power conditions. As the results, the NOx emissions are found to be a strong function of combustion inlet air temperature and fuel air equivalence ratio but a weaker function of inlet air pressure. With these three equations, the NOx emissions performance of this injector concept is calculated as a 66% reduction relative to the ICAO CAEP-6 standard using a 55:1 pressure-ratio engine cycle. Uncertainty in the NOx emissions estimation increases as the extrapolation range departs from the experimental conditions. Since maximum inlet air pressure tested was less than 50% of the full power engine inlet air pressure, a future experiment at higher inlet air pressure conditions is needed to confirm the NOx emissions dependency on inlet air pressure.

Live-cell imaging of G-actin dynamics using sequential FDAP

PubMed Central

Kiuchi, Tai; Nagai, Tomoaki; Ohashi, Kazumasa; Watanabe, Naoki; Mizuno, Kensaku

2011-01-01

Various microscopic techniques have been developed to understand the mechanisms that spatiotemporally control actin filament dynamics in live cells. Kinetic data on the processes of actin assembly and disassembly on F-actin have been accumulated. However, the kinetics of cytoplasmic G-actin, a key determinant for actin polymerization, has remained unclear because of a lack of appropriate methods to measure the G-actin concentration quantitatively. We have developed two new microscopic techniques based on the fluorescence decay after photoactivation (FDAP) time-lapse imaging of photoswitchable Dronpa-labeled actin. These techniques, sequential FDAP (s-FDAP) and multipoint FDAP, were used to measure the time-dependent changes in and spatial distribution of the G-actin concentration in live cells. Use of s-FDAP provided data on changes in the G-actin concentration with high temporal resolution; these data were useful for the model analysis of actin assembly processes in live cells. The s-FDAP analysis also provided evidence that the cytoplasmic G-actin concentration substantially decreases after cell stimulation and that the extent of stimulus-induced actin assembly and cell size extension are linearly correlated with the G-actin concentration before cell stimulation. The advantages of using s-FDAP and multipoint FDAP to measure spatiotemporal G-actin dynamics and the roles of G-actin concentration and ADF/cofilin in stimulus-induced actin assembly and lamellipodium extension in live cells are discussed. PMID:22754616

NASA Multipoint LDI Development

NASA Technical Reports Server (NTRS)

Tacina, Robert

2001-01-01

Multipoint Lean-Direct-Injection (LDI) is a combustor concept in which a large number of fuel injectors and fuel-air mixers are used to quickly and uniformly mix the fuel and air so that ultralow levels of NO, are produced. Each fuel injector has an air swirler associated with it for fuel-air mixing and to establish a small recirculation and burning zone. A concept in which there are 36 fuel injectors in the space of a conventional single fuel injector has been tested in a flame tube. A greater than 80 percent reduction in NO, at high power conditions (400 psia, 1000 "Finlet) was achieved. Alternate concepts with 9,25,36 or 49 fuel injectors are being investigated in flame tube tests for their low NO, potential and with fuel staging to improve the turn-down ratio at low power conditions. A preliminary sector concept of a large engine design has been successfully tested at inlet conditions of 700 psia and 1100 O F . This concept had one half the number of fuel injectors per square inch as the flame tube configuration with 36 fuel injectors, and the NO, reduction was 65 percent of the ICAO standard. Future regional engine size sector tests are planned for the 2nd quarter of FY02 and large engine size sector tests for the 1st quarter of FY03.

Development of a novel multi-point plastic scintillation detector with a single optical transmission line for radiation dose measurement*

PubMed Central

Therriault-Proulx, François; Archambault, Louis; Beaulieu, Luc; Beddar, Sam

2013-01-01

Purpose The goal of this study was to develop a novel multi-point plastic scintillation detector (mPSD) capable of measuring the dose accurately at multiple positions simultaneously using a single optical transmission line. Methods A 2-point mPSD used a band-pass approach that included splitters, color filters, and an EMCCD camera. The 3-point mPSD was based on a new full-spectrum approach, in which a spectrograph was coupled to a CCD camera. Irradiations of the mPSDs and of an ion chamber were performed with a 6-MV photon beam at various depths and lateral positions in a water tank. Results For the 2-point mPSD, the average relative differences between mPSD and ion chamber measurements for the depth-dose were 2.4±1.6% and 1.3±0.8% for BCF-60 and BCF-12, respectively. For the 3-point mPSD, the average relative differences over all conditions were 2.3±1.1%, 1.6±0.4%, and 0.32±0.19% for BCF-60, BCF-12, and BCF-10, respectively. Conclusions This study demonstrates the practical feasibility of mPSDs. This type of detector could be very useful for pre-treatment quality assurance applications as well as an accurate tool for real-time in vivo dosimetry. PMID:23060069

NOx Emissions Performance and Correlation Equations for a Multipoint LDI Injector

NASA Technical Reports Server (NTRS)

He, Zhuohui J.; Chang, Clarence T.; Follen, Caitlin E.

2014-01-01

Lean Direct Injection (LDI) is a combustor concept that reduces nitrogen oxides (NOx) emissions. This paper looks at a 3-zone multipoint LDI concept developed by Parker Hannifin Corporation. The concept was tested in a flame-tube test facility at NASA Glenn Research Center. Due to test facility limitations, such as inlet air temperature and pressure, the flame-tube test was not able to cover the full set of engine operation conditions. Three NOx correlation equations were developed based on assessing NOx emissions dependencies on inlet air pressure (P3), inlet air temperature (T3), and fuel air equivalence ratio (?) to estimate the NOx emissions at the unreachable high engine power conditions. As the results, the NOx emissions are found to be a strong function of combustion inlet air temperature and fuel air equivalence ratio but a weaker function of inlet air pressure. With these three equations, the NOx emissions performance of this injector concept is calculated as a 66 percent reduction relative to the ICAO CAEP-6 standard using a 55:1 pressure-ratio engine cycle. Uncertainty in the NOx emissions estimation increases as the extrapolation range departs from the experimental conditions. Since maximum inlet air pressure tested was less than 50 percent of the full power engine inlet air pressure, a future experiment at higher inlet air pressure conditions is needed to confirm the NOx emissions dependency on inlet air pressure.

Community Services: Block Grant Helps Address Local Social Service Needs. Report to Congressional Committees.

ERIC Educational Resources Information Center

General Accounting Office, Washington, DC. Div. of Human Resources.

The overall objective of this review was to obtain information on several issues raised in the Congress pertaining to the reauthorization of the Community Services Block Grant (CSBG) program. The information includes: (1) what CSBG funds are used for and whether CSBG-supported services duplicate other local social service programs, (2) what role…

The Impacts of the WIA One-Stop Center Model on Local Training Services

ERIC Educational Resources Information Center

Cajayon, Felicito

2012-01-01

This study examined the Workforce Investment Act (WIA) One-Stop Center model, which is the local service mechanism for providing employment and training services. It reviewed the processes and service patterns of four program designs that offer an array of services that align with the WIA program's allowable activities. The purpose of the study…

Community-Based Information Technology Services 1: What (Some) Users Want.

ERIC Educational Resources Information Center

Caldwell, Barrett S.; Robertson, Jenifer W.

1996-01-01

Addresses issues regarding the design of electronic community information services and user preferences for information services. Presents results of surveying 80 Wisconsin residents about their community information needs. The following community information needs were identified: library services, local government and banking, local calendars of…

Changes in Local Public Health System Performance Before and After Attainment of National Accreditation Standards.

PubMed

Ingram, Richard C; Mays, Glen P; Kussainov, Nurlan

The aim of this study is to investigate the impact of Public Health Accreditation Board (PHAB) accreditation on the delivery of public health services and on participation from other sectors in the delivery of public health services in local public health systems. This study uses a longitudinal repeated measures design to identify differences between a cohort of public health systems containing PHAB-accredited local health departments and a cohort of public health systems containing unaccredited local health departments. It uses data spanning from 2006 to 2016. This study examines a cohort of local public health systems that serves large populations and contains unaccredited and PHAB-accredited local health departments. Data in this study were collected from the directors of health departments that include local public health systems followed in the National Longitudinal Study of Public Health Systems. The intervention examined is PHAB accreditation. The study focuses on 4 areas: the delivery of core public health services, local health department contribution toward these services, participation in the delivery of these services by other members of the public health system, and public health system makeup. Prior to the advent of accreditation, public health systems containing local health departments that were later accredited by PHAB appear quite similar to their unaccredited peers. Substantial differences between the 2 cohorts appear to manifest themselves after the advent of accreditation. Specifically, the accredited cohort seems to offer a broader array of public health services, involve more partners in the delivery of those services, and enjoy a higher percentage of comprehensive public health systems. The results of this study suggest that accreditation may yield significant benefits and may help public health systems develop the public health system capital necessary to protect and promote the public's health.

Primary care perceptions of neurology and neurology services.

PubMed

Loftus, Angela M; Wade, Carrie; McCarron, Mark O

2016-06-01

Neurophobia (fear of neural sciences) and evaluation of independent sector contracts in neurology have seldom been examined among general practitioners (GPs). A questionnaire determined GPs' perceptions of neurology compared with other medical specialties. GP experiences of neurology services with independent sector companies and the local National Health Service (NHS) were compared. Areas of potential improvement in NHS neurology services were recorded from thematic analyses. Among 76 GPs neurology was perceived to be as interesting as other medical specialties. GPs reported less knowledge, more difficulty and less confidence in neurology compared with other medical specialties. There was a preference for a local NHS neurology service (p<0.001), which was easier to contact (p<0.001) and provided better follow-up. GPs reported that local neurology services provided better patient satisfaction. GPs prefer local NHS neurology services to independent sector contracts. GPs' evaluations should inform commissioning of neurology services. Combating neurophobia should be an integral part of responsive commissioning. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Improving healthcare for Aboriginal Australians through effective engagement between community and health services.

PubMed

Durey, Angela; McEvoy, Suzanne; Swift-Otero, Val; Taylor, Kate; Katzenellenbogen, Judith; Bessarab, Dawn

2016-07-07

Effectively addressing health disparities between Aboriginal and non-Aboriginal Australians is long overdue. Health services engaging Aboriginal communities in designing and delivering healthcare is one way to tackle the issue. This paper presents findings from evaluating a unique strategy of community engagement between local Aboriginal people and health providers across five districts in Perth, Western Australia. Local Aboriginal community members formed District Aboriginal Health Action Groups (DAHAGs) to collaborate with health providers in designing culturally-responsive healthcare. The purpose of the strategy was to improve local health service delivery for Aboriginal Australians. The evaluation aimed to identify whether the Aboriginal community considered the community engagement strategy effective in identifying their health service needs, translating them to action by local health services and increasing their trust in these health services. Participants were recruited using purposive sampling. Qualitative data was collected from Aboriginal participants and health service providers using semi-structured interviews or yarning circles that were recorded, transcribed and independently analysed by two senior non-Aboriginal researchers. Responses were coded for key themes, further analysed for similarities and differences between districts and cross-checked by the senior lead Aboriginal researcher to avoid bias and establish reliability in interpreting the data. Three ethics committees approved conducting the evaluation. Findings from 60 participants suggested the engagement process was effective: it was driven and owned by the Aboriginal community, captured a broad range of views and increased Aboriginal community participation in decisions about their healthcare. It built community capacity through regular community forums and established DAHAGs comprising local Aboriginal community members and health service representatives who met quarterly and were supported by the Aboriginal Health Team at the local Population Health Unit. Participants reported health services improved in community and hospital settings, leading to increased access and trust in local health services. The evaluation concluded that this process of actively engaging the Aboriginal community in decisions about their health care was a key element in improving local health services, increasing Aboriginal people's trust and access to care.

Mental Health Services in Local Jails: Report of a Special National Workshop. Crime and Delinquency Issues: A Monograph Series.

ERIC Educational Resources Information Center

Dunn, Christopher S., Ed.; Steadman, Henry J., Ed.

This document presents papers prepared for the 1978 Special National Workshop on Mental Health Services in Local Jails. The articles provide information on several topics: (1) the nature and extent of mental health needs in local jails; (2) assessment and intervention approaches for addressing these needs; (3) mental health service delivery…

32 CFR 1602.14 - Local board.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Local board. 1602.14 Section 1602.14 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.14 Local board. A local board or a panel thereof of the Selective Service System is a group of not less...

32 CFR 1602.14 - Local board.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Local board. 1602.14 Section 1602.14 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.14 Local board. A local board or a panel thereof of the Selective Service System is a group of not less...

Improving quality of life for older people in the community: findings from a local Partnerships for Older People Project innovation and evaluation.

PubMed

Roe, Brenda; Beech, Roger; Harris, Michelle; Beech, Bernard; Russell, Wanda; Gent, Deborah; Lord, Kathryn; Dickinson, Angela

2011-07-01

Partnerships for Older People Projects (POPP) was a national initiative in England aimed at improving health, well-being and quality of life (QoL) for older people by developing local services. This development paper reports the key findings of a local evaluation in relation to quality of life, well-being and health-related QoL to provide practical understanding at the local level about what this means in relation to the schemes delivered. To identify the impact of POPP schemes received by older people in Wigan on their QoL and well-being; and establish their feedback on services using local indicators. Convenience samples of older people receiving services from three selected 'community facing low level' schemes were recruited over a two-month period. They completed a semi-structured questionnaire at baseline (T1) and at follow-up 6 weeks later (T2). Information was collected on health status and health-related QoL using the EQ-5D, biographical information, overall QoL and well-being as part of the national evaluation and a local indicator, feedback on services. Response rates were 70% (T1 45/64, mean age 72 years) and 43% at T2 (25/58, mean age 55 years). Following receipt of these schemes improvements were found for self care, anxiety and depression, health status and QoL although these differences were not statistically significant due to the small sample size and loss to follow-up. Feedback on local service use related to schemes 'being fit for purpose' and 'aspects of service delivery'. This local evaluation illustrates a pragmatic approach to service development and delivery of preventative services, with potential to benefit health and well-being of older people and support their continued living independently in the community. It provides detail and better understanding of what this means locally to people in context of national findings.

Advanced information processing system: Local system services

NASA Technical Reports Server (NTRS)

Burkhardt, Laura; Alger, Linda; Whittredge, Roy; Stasiowski, Peter

1989-01-01

The Advanced Information Processing System (AIPS) is a multi-computer architecture composed of hardware and software building blocks that can be configured to meet a broad range of application requirements. The hardware building blocks are fault-tolerant, general-purpose computers, fault-and damage-tolerant networks (both computer and input/output), and interfaces between the networks and the computers. The software building blocks are the major software functions: local system services, input/output, system services, inter-computer system services, and the system manager. The foundation of the local system services is an operating system with the functions required for a traditional real-time multi-tasking computer, such as task scheduling, inter-task communication, memory management, interrupt handling, and time maintenance. Resting on this foundation are the redundancy management functions necessary in a redundant computer and the status reporting functions required for an operator interface. The functional requirements, functional design and detailed specifications for all the local system services are documented.

Contract management in USA hospitals: service duplication and access within local markets.

PubMed

Carey, Kathleen; Dor, Avi

2008-08-01

This paper examines the extent to which hospitals that are under external contract management engage in service duplication, as well as the degree to which the various services they offer contribute to or detract from community access. The study incorporates all USA hospitals using data from the American Hospital Association Annual Survey Database, supplemented by county level measures obtained from the area resource file (ARF). Using data on the 3794 hospitals classified as acute care facilities in 2002, we performed a set of logistic regressions that analyzed whether a hospital offered each of 74 distinct services. For each service (regression), key independent variables measured the number of other hospitals in the local market area that also offered the service. Local area market definitions are the areas circumscribed by the hospital within distances of 10 and 20 miles. Results suggest that contract-managed (CM) hospitals display a more competitive pattern (service duplication) than hospitals in general, but CM hospitals that are the sole provider of services locally are less likely to offer services than traditionally managed sole hospital providers. Contract management does not appear to offer any particular advantages in improving access to hospital services.

Multipoint correlators in the Abelian sandpile model

NASA Astrophysics Data System (ADS)

Poncelet, Adrien; Ruelle, Philippe

2017-12-01

We revisit the calculation of height correlations in the two-dimensional Abelian sandpile model by taking advantage of a technique developed recently by Kenyon and Wilson. The formalism requires to equip the usual graph Laplacian, ubiquitous in the context of cycle-rooted spanning forests, with a complex connection. In the case at hand, the connection is constant and localized along a semi-infinite defect line (zipper). In the appropriate limit of a trivial connection, it allows one to count spanning forests whose components contain prescribed sites, which are of direct relevance for height correlations in the sandpile model. Using this technique, we first rederive known 1- and 2-site lattice correlators on the plane and upper half-plane, more efficiently than what has been done so far. We also compute explicitly the (new) next-to-leading order in the distances (r-4 for 1-site on the upper half-plane, r-6 for 2-site on the plane). We extend these results by computing new correlators involving one arbitrary height and a few heights 1 on the plane and upper half-plane, for the open and closed boundary conditions. We examine our lattice results from the conformal point of view, and confirm the full consistency with the specific features currently conjectured to be present in the associated logarithmic conformal field theory.

Kinetic solvers with adaptive mesh in phase space

NASA Astrophysics Data System (ADS)

Arslanbekov, Robert R.; Kolobov, Vladimir I.; Frolova, Anna A.

2013-12-01

An adaptive mesh in phase space (AMPS) methodology has been developed for solving multidimensional kinetic equations by the discrete velocity method. A Cartesian mesh for both configuration (r) and velocity (v) spaces is produced using a “tree of trees” (ToT) data structure. The r mesh is automatically generated around embedded boundaries, and is dynamically adapted to local solution properties. The v mesh is created on-the-fly in each r cell. Mappings between neighboring v-space trees is implemented for the advection operator in r space. We have developed algorithms for solving the full Boltzmann and linear Boltzmann equations with AMPS. Several recent innovations were used to calculate the discrete Boltzmann collision integral with dynamically adaptive v mesh: the importance sampling, multipoint projection, and variance reduction methods. We have developed an efficient algorithm for calculating the linear Boltzmann collision integral for elastic and inelastic collisions of hot light particles in a Lorentz gas. Our AMPS technique has been demonstrated for simulations of hypersonic rarefied gas flows, ion and electron kinetics in weakly ionized plasma, radiation and light-particle transport through thin films, and electron streaming in semiconductors. We have shown that AMPS allows minimizing the number of cells in phase space to reduce the computational cost and memory usage for solving challenging kinetic problems.

Electron transport in stepped Bi2Se3 thin films

NASA Astrophysics Data System (ADS)

Bauer, S.; Bobisch, C. A.

2017-08-01

We analyse the electron transport in a 16 quintuple layer thick stepped Bi2Se3 film grown on Si(1 1 1) by means of scanning tunnelling potentiometry (STP) and multi-point probe measurements. Scanning tunnelling microscopy images reveal that the local structure of the Bi2Se3 film is dominated by terrace steps and domain boundaries. From a microscopic study on the nm scale by STP, we find a mostly linear gradient of the voltage on the Bi2Se3 terraces which is interrupted by voltage drops at the position of the domain boundaries. The voltage drops indicate that the domain boundaries are scatterers for the electron transport. Macroscopic resistance measurements (2PP and in-line 4PP measurement) on the µm scale support the microscopic results. An additional rotational square 4PP measurement shows an electrical anisotropy of the sheet conductance parallel and perpendicular to the Bi2Se3 steps of about 10%. This is a result of the anisotropic step distribution at the stepped Bi2Se3 surface while domain boundaries are distributed isotropically. The determined value of the conductivity of the Bi2Se3 steps of about 1000 S cm-1 verifies the value of an earlier STP study.

Conformal invariance of the Lungren-Monin-Novikov equations for vorticity fields in 2D turbulence

NASA Astrophysics Data System (ADS)

Grebenev, V. N.; Wacławczyk, M.; Oberlack, M.

2017-10-01

We study the statistical properties of the vorticity field in two-dimensional turbulence. The field is described in terms of the infinite Lundgren-Monin-Novikov (LMN) chain of equations for multi-point probability density functions (pdf’s) of vorticity. We perform a Lie group analysis of the first equation in this chain using the direct method based on the canonical Lie-Bäcklund transformations devised for integro-differential equations. We analytically show that the conformal group is broken for the first LMN equation i.e. for the 1-point pdf at least for the inviscid case but the equation is still conformally invariant on the associated characteristic with zero-vorticity. Then, we demonstrate that this characteristic is conformally transformed. We find this outcome coincides with the numerical results about the conformal invariance of the statistics of zero-vorticity isolines, see e.g. Falkovich (2007 Russian Math. Surv. 63 497-510). The conformal symmetry can be understood as a ‘local scaling’ and its traces in two-dimensional turbulence were already discussed in the literature, i.e. it was conjectured more than twenty years ago in Polyakov (1993 Nucl. Phys. B 396 367-85) and clearly validated experimentally in Bernard et al (2006 Nat. Phys. 2 124-8).

Kinetic solvers with adaptive mesh in phase space.

PubMed

Arslanbekov, Robert R; Kolobov, Vladimir I; Frolova, Anna A

2013-12-01

An adaptive mesh in phase space (AMPS) methodology has been developed for solving multidimensional kinetic equations by the discrete velocity method. A Cartesian mesh for both configuration (r) and velocity (v) spaces is produced using a "tree of trees" (ToT) data structure. The r mesh is automatically generated around embedded boundaries, and is dynamically adapted to local solution properties. The v mesh is created on-the-fly in each r cell. Mappings between neighboring v-space trees is implemented for the advection operator in r space. We have developed algorithms for solving the full Boltzmann and linear Boltzmann equations with AMPS. Several recent innovations were used to calculate the discrete Boltzmann collision integral with dynamically adaptive v mesh: the importance sampling, multipoint projection, and variance reduction methods. We have developed an efficient algorithm for calculating the linear Boltzmann collision integral for elastic and inelastic collisions of hot light particles in a Lorentz gas. Our AMPS technique has been demonstrated for simulations of hypersonic rarefied gas flows, ion and electron kinetics in weakly ionized plasma, radiation and light-particle transport through thin films, and electron streaming in semiconductors. We have shown that AMPS allows minimizing the number of cells in phase space to reduce the computational cost and memory usage for solving challenging kinetic problems.

Modeling solar energetic particle events using ENLIL heliosphere simulations

NASA Astrophysics Data System (ADS)

Luhmann, J. G.; Mays, M. L.; Odstrcil, D.; Li, Yan; Bain, H.; Lee, C. O.; Galvin, A. B.; Mewaldt, R. A.; Cohen, C. M. S.; Leske, R. A.; Larson, D.; Futaana, Y.

2017-07-01

Solar energetic particle (SEP) event modeling has gained renewed attention in part because of the availability of a decade of multipoint measurements from STEREO and L1 spacecraft at 1 AU. These observations are coupled with improving simulations of the geometry and strength of heliospheric shocks obtained by using coronagraph images to send erupted material into realistic solar wind backgrounds. The STEREO and ACE measurements in particular have highlighted the sometimes surprisingly widespread nature of SEP events. It is thus an opportune time for testing SEP models, which typically focus on protons 1-100 MeV, toward both physical insight to these observations and potentially useful space radiation environment forecasting tools. Some approaches emphasize the concept of particle acceleration and propagation from close to the Sun, while others emphasize the local field line connection to a traveling, evolving shock source. Among the latter is the previously introduced SEPMOD treatment, based on the widely accessible and well-exercised WSA-ENLIL-cone model. SEPMOD produces SEP proton time profiles at any location within the ENLIL domain. Here we demonstrate a SEPMOD version that accommodates multiple, concurrent shock sources occurring over periods of several weeks. The results illustrate the importance of considering longer-duration time periods and multiple CME contributions in analyzing, modeling, and forecasting SEP events.

Local, regional and national interoperability in hospital-level systems architecture.

PubMed

Mykkänen, J; Korpela, M; Ripatti, S; Rannanheimo, J; Sorri, J

2007-01-01

Interoperability of applications in health care is faced with various needs by patients, health professionals, organizations and policy makers. A combination of existing and new applications is a necessity. Hospitals are in a position to drive many integration solutions, but need approaches which combine local, regional and national requirements and initiatives with open standards to support flexible processes and applications on a local hospital level. We discuss systems architecture of hospitals in relation to various processes and applications, and highlight current challenges and prospects using a service-oriented architecture approach. We also illustrate these aspects with examples from Finnish hospitals. A set of main services and elements of service-oriented architectures for health care facilities are identified, with medium-term focus which acknowledges existing systems as a core part of service-oriented solutions. The services and elements are grouped according to functional and interoperability cohesion. A transition towards service-oriented architecture in health care must acknowledge existing health information systems and promote the specification of central processes and software services locally and across organizations. Software industry best practices such as SOA must be combined with health care knowledge to respond to central challenges such as continuous change in health care. A service-oriented approach cannot entirely rely on common standards and frameworks but it must be locally adapted and complemented.

High-Fidelity Aerodynamic Shape Optimization for Natural Laminar Flow

NASA Astrophysics Data System (ADS)

Rashad, Ramy

To ensure the long-term sustainability of aviation, serious effort is underway to mitigate the escalating economic, environmental, and social concerns of the industry. Significant improvement to the energy efficiency of air transportation is required through the research and development of advanced and unconventional airframe and engine technologies. In the quest to reduce airframe drag, this thesis is concerned with the development and demonstration of an effective design tool for improving the aerodynamic efficiency of subsonic and transonic airfoils. The objective is to advance the state-of-the-art in high-fidelity aerodynamic shape optimization by incorporating and exploiting the phenomenon of laminar-turbulent transition in an efficient manner. A framework for the design and optimization of Natural Laminar Flow (NLF) airfoils is developed and demonstrated with transition prediction capable of accounting for the effects of Reynolds number, freestream turbulence intensity, Mach number, and pressure gradients. First, a two-dimensional Reynolds-averaged Navier-Stokes (RANS) flow solver has been extended to incorporate an iterative laminar-turbulent transition prediction methodology. The natural transition locations due to Tollmien-Schlichting instabilities are predicted using the simplified eN envelope method of Drela and Giles or, alternatively, the compressible form of the Arnal-Habiballah-Delcourt criterion. The boundary-layer properties are obtained directly from the Navier-Stokes flow solution, and the transition to turbulent flow is modeled using an intermittency function in conjunction with the Spalart-Allmaras turbulence model. The RANS solver is subsequently employed in a gradient-based sequential quadratic programming shape optimization framework. The laminar-turbulent transition criteria are tightly coupled into the objective and gradient evaluations. The gradients are obtained using a new augmented discrete-adjoint formulation for non-local transition criteria. Using the eN transition criterion, the proposed framework is applied to the single and multipoint optimization of subsonic and transonic airfoils, leading to robust NLF designs. The aerodynamic design requirements over a range of cruise flight conditions are cast into a multipoint optimization problem through a composite objective defined using a weighted integral of the operating points. To study and quantify off-design performance, a Pareto front is formed using a weighted objective combining free-transition and fully-turbulent operating conditions. Next we examine the sensitivity of NLF design to the freestream disturbance environment, highlighting the on- and off-design performance at different critical N-factors. Finally, we propose and demonstrate a technique to enable the design of airfoils with robust performance over a range of critical N-factors.

Bluetooth Low Power Modes Applied to the Data Transportation Network in Home Automation Systems.

PubMed

Etxaniz, Josu; Aranguren, Gerardo

2017-04-30

Even though home automation is a well-known research and development area, recent technological improvements in different areas such as context recognition, sensing, wireless communications or embedded systems have boosted wireless smart homes. This paper focuses on some of those areas related to home automation. The paper draws attention to wireless communications issues on embedded systems. Specifically, the paper discusses the multi-hop networking together with Bluetooth technology and latency, as a quality of service (QoS) metric. Bluetooth is a worldwide standard that provides low power multi-hop networking. It is a radio license free technology and establishes point-to-point and point-to-multipoint links, known as piconets, or multi-hop networks, known as scatternets. This way, many Bluetooth nodes can be interconnected to deploy ambient intelligent networks. This paper introduces the research on multi-hop latency done with park and sniff low power modes of Bluetooth over the test platform developed. Besides, an empirical model is obtained to calculate the latency of Bluetooth multi-hop communications over asynchronous links when links in scatternets are always in sniff or the park mode. Smart home devices and networks designers would take advantage of the models and the estimation of the delay they provide in communications along Bluetooth multi-hop networks.

Bluetooth Low Power Modes Applied to the Data Transportation Network in Home Automation Systems

PubMed Central

Etxaniz, Josu; Aranguren, Gerardo

2017-01-01

Even though home automation is a well-known research and development area, recent technological improvements in different areas such as context recognition, sensing, wireless communications or embedded systems have boosted wireless smart homes. This paper focuses on some of those areas related to home automation. The paper draws attention to wireless communications issues on embedded systems. Specifically, the paper discusses the multi-hop networking together with Bluetooth technology and latency, as a quality of service (QoS) metric. Bluetooth is a worldwide standard that provides low power multi-hop networking. It is a radio license free technology and establishes point-to-point and point-to-multipoint links, known as piconets, or multi-hop networks, known as scatternets. This way, many Bluetooth nodes can be interconnected to deploy ambient intelligent networks. This paper introduces the research on multi-hop latency done with park and sniff low power modes of Bluetooth over the test platform developed. Besides, an empirical model is obtained to calculate the latency of Bluetooth multi-hop communications over asynchronous links when links in scatternets are always in sniff or the park mode. Smart home devices and networks designers would take advantage of the models and the estimation of the delay they provide in communications along Bluetooth multi-hop networks. PMID:28468294

Survivable architectures for time and wavelength division multiplexed passive optical networks

NASA Astrophysics Data System (ADS)

Wong, Elaine

2014-08-01

The increased network reach and customer base of next-generation time and wavelength division multiplexed PON (TWDM-PONs) have necessitated rapid fault detection and subsequent restoration of services to its users. However, direct application of existing solutions for conventional PONs to TWDM-PONs is unsuitable as these schemes rely on the loss of signal (LOS) of upstream transmissions to trigger protection switching. As TWDM-PONs are required to potentially use sleep/doze mode optical network units (ONU), the loss of upstream transmission from a sleeping or dozing ONU could erroneously trigger protection switching. Further, TWDM-PONs require its monitoring modules for fiber/device fault detection to be more sensitive than those typically deployed in conventional PONs. To address the above issues, three survivable architectures that are compliant with TWDM-PON specifications are presented in this work. These architectures combine rapid detection and protection switching against multipoint failure, and most importantly do not rely on upstream transmissions for LOS activation. Survivability analyses as well as evaluations of the additional costs incurred to achieve survivability are performed and compared to the unprotected TWDM-PON. Network parameters that impact the maximum achievable network reach, maximum split ratio, connection availability, fault impact, and the incremental reliability costs for each proposed survivable architecture are highlighted.

2 CFR Appendix V to Part 200 - State/Local Government and Indian Tribe-Wide Central Service Cost Allocation Plans

Code of Federal Regulations, 2014 CFR

2014-01-01

... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false State/Local Government and Indian Tribe-Wide Central Service Cost Allocation Plans V Appendix V to Part 200 Grants and Agreements Office of Management..., App. V Appendix V to Part 200—State/Local Government and Indian Tribe-Wide Central Service Cost...

Local Power: Tribe & Township.

ERIC Educational Resources Information Center

Matlala, Padi; Moloi, Dudley

1995-01-01

Examines the service infrastructure of a rural township in South Africa and the struggle to acquire services like water and electricity. Discusses the interaction of a system of transitional local councils and tribal authorities in the face of local government elections. (LZ)

Local Service Learning in Teacher Preparation Program

ERIC Educational Resources Information Center

Nuangchalerm, Prasart

2016-01-01

The local knowledge is simply integrated in education and learning process. This study aims to promote local knowledge in school through service learning. The learning process is employed herbal plants to reinforce students learn how to sustain local knowledge with modern life and 21st century classroom. Participants consisted of 42 pre-service…

A Fully Integrated Micro-Magnometer/Microspacecraft for Multipoint Measurements: The Free-Flyer Magnometer

NASA Technical Reports Server (NTRS)

Goldstein, R.; Miller, L. N.; Fossum, E.; Pain, B.; Randolph, J. E.; Turner, P. R.; Cutting, E.

1995-01-01

In the decades since the advent of in situ plasma measurements on board spacecraft, the instrumentation has grown bigger, heavier, and more complex as our understanding of space plasmas improves and our appetite for more information increases...There has thus been a recent interest in the miniaturization of both spacecraft and the instrument payload... This paper describes the results and status of an ongoing design study to understand the problems and trade space of fully integrating an instrument into a micro-spacecraft.

Measurements of Vorticity Vectors in Couette Flow with the Vorticity Optical Probe

DTIC Science & Technology

1991-05-01

Web 1981). The three components of the vorticity vector are measured, any two of them quite accurately. Multipoint measurement arrangements have been...the distribution of trajectory lengths is given by POrN ) rN O<rN<R. fwio-R R -rN where R is the angular measure of the detector radius. (The random...orticitv were performed deep within the viscous sublaver v 2.3). .At y < 10. the fluctuating vortici, ,tatistics show good agreement with the simulatins of

KSC-06pd0260

NASA Image and Video Library

2005-12-27

VANDENBERG AIR FORCE BASE, CALIF. - Inside Orbital Sciences Building 1555 at Vandenberg Air Force Base in California, workers get ready to install one of the fins on the aft skirt of the Pegasus XL rocket that will launch the Space Technology 5 spacecraft later this month. ST5 contains three micro-satellites that will be positioned in a "string of pearls" constellation to perform simultaneous multi-point measurements of the Earth's magnetic field using highly sensitive magnetometers. The scheduled launch date is Feb. 28.

NRL EIGHTH CARD Program Interim Progress Report, 1 March 1969 to 30 September 1969

DTIC Science & Technology

1969-12-31

methods to measure the water vapor content of the atmosphere have been inves- tigated. One is based on the psychrometer method of measuring wet and dry bulb...over and under configuration. A shipboard psychrometer consisting of the sensors and blower and an 18.5-foot-high intake stack has been mounted on a...small boat. The intake stack may be partially dismounted to pro- vide a 9-foot intake level. The readout for the psychrometer is a multipoint Leeds and

Current and planned shared service arrangements in Wisconsin local and tribal health departments.

PubMed

Madamala, Kusuma; Young, Nancy; Young, Dustin; Giese, Lieske; Brandenberg, Terry; Zahner, Susan

2014-01-01

The objective of this study was to explore current and future use of shared service arrangements as a management strategy to increase capacity to provide public health essential services in Wisconsin. An online cross-sectional survey of 99 local and tribal health departments in Wisconsin was conducted. Select variables from the 2010 Wisconsin Local Health Department Survey were merged. Other data sources included results from a Board of Health governance analysis and the Wisconsin Department of Health Services region data. Descriptive analysis was performed of current and future shared service arrangements and the characteristics of the types of arrangements and agreements in place. Ninety-one of 99 Wisconsin local and tribal health departments responded, yielding a 92% response rate. Seventy-one percent of respondents currently share services with 1 or more other health departments. More frequent arrangements were present in programmatic areas than in departmental operations. Most frequently reported motivators include making better use of resources, providing better services, and responding to program requirements. Extensive qualitative comments indicate arrangements accomplished what the local health department hoped it would with perceived gains in efficiency and effectiveness. There is widespread use of shared services among health departments in Wisconsin. Extensive qualitative comments suggest participant satisfaction with what the arrangements have accomplished. Motivating factors in developing the arrangements and limited mention of expiration dates suggest continued study of how these arrangements may evolve. Further examination of shared services as a potential mechanism to advance service effectiveness and efficiency is needed.

Analysis of Terrestrial Interference Protection from UAS CNPC Satellite Transmitters

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.; Wilson, Jeffrey D.; Bishop, William D.

2016-01-01

Unmanned aircraft (UA) are projected to have a major impact on future aviation. Larger UA operating at altitudes above 3000 feet will require at least occasional access to non-segregated, that is, controlled airspace. In order for unmanned aircraft to be integrated into the airspace and operate with other commercial aircraft, a very reliable command and control (a. k. a. control and non-payload communications, (CNPC)) link is required. For operations covering large distances or over remote locations, a beyond-line-of-sight (BLOS) CNPC link implemented through a satellite will almost always be required. Protected aviation spectrum (aeronautical mobile satellite (route) service, or AMS(R)S) would normally be used for such a safety-critical link, however studies have shown that currently available aviation safety satellite spectrum is inadequate to support the projected BLOS CNPC link bandwidth requirements. To address this inadequacy, the 2015 World Radio communication Conference studied the possible use of the Fixed Satellite Service (FSS) to provide CNPC, including possible allocations in Ku-Band and Ka-Band, under Agenda Item (AI) 1.5. Although UA CNPC satellite links in these bands were shown to meet operational availability and continuity requirements, a serious complication exists in that there are also terrestrial service allocations in these bands, in particular, Fixed Service (FS) point-to-point and point-to-multipoint microwave digital links. During the WRC-15 study cycle, much opposition to AI 1.5 was generated based on fears that UA CNPC satellite transmitters in these bands would impose unacceptable levels of interference to the FS receivers. NASA analyzed the possible interference from the UA transmitters based on probable UA transmission and FS receiver characteristics, and UA traffic distributions and densities to determine conditions under which UA could operate without imposing unacceptable interference levels to the FS. Ultimately, UA power flux density transmission limits were proposed as a way to insure protection of FS receivers and further studies were prepared on the various proposals. This paper presents the results of these studies and discusses possible implications on future UA BLOS operations.

An Exploration of the Effects of Corporate Management on Selected Aspects of the Education Service in English Local Government.

ERIC Educational Resources Information Center

Housego, Ian E.

1985-01-01

The Local Government Act of 1972 redefined local government boundaries in England and reduced the number of local education authorities. Ancillary corporate management "reforms" ultimately reduced the chief education officer's power, enhanced ruling party and chief executive power, and heavily politicized the education service. (49…

Perceptions of Local Health Care Quality in 7 Rural Communities with Telemedicine

ERIC Educational Resources Information Center

Nesbitt, Thomas S.; Marcin, James P.; Daschbach, Martha M.; Cole, Stacey L.

2005-01-01

Rural health services are difficult to maintain because of low patient volumes, limited numbers of providers, and unfavorable economies of scale. Rural patients may perceive poor quality in local health care, directly impacting the sustainability of local health care services. This study examines perceptions of local health care quality in 7…

Determinants of Service Expansion in Local Communities: Organizational Needs or Needs of the Elderly?

ERIC Educational Resources Information Center

Sheldon, Ann Workman

Providing comprehensive services for the elderly in local communities presents planners and potential users with a complex set of problems. The development of new or expanded service to the elderly was examined within an ecologically informed resource dependency model to assess the effect on service expansion of organizational maintenance factors…

Evaluations of Firms and Professionals Who Provide Consumer Services. An Annotated Bibliography of Consumer Services.

ERIC Educational Resources Information Center

Jackson, Gregg B.; Meyer, Francine H.

This annotated bibliography contains summaries of studies of consumer services in 39 fields, plus summaries of publications of interest to consumer advocates, published during the past 10 years. Since most service providers do business in a single locale, the evaluations are usually local in scope (for example, a comparison of major appliance…

47 CFR 32.5000 - Basic local service revenue.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 2 2011-10-01 2011-10-01 false Basic local service revenue. 32.5000 Section 32.5000 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions For Revenue Accounts § 32.5000 Basic...

47 CFR 32.5000 - Basic local service revenue.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 2 2014-10-01 2014-10-01 false Basic local service revenue. 32.5000 Section 32.5000 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions For Revenue Accounts § 32.5000 Basic...

47 CFR 32.5000 - Basic local service revenue.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 2 2013-10-01 2013-10-01 false Basic local service revenue. 32.5000 Section 32.5000 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Instructions For Revenue Accounts § 32.5000 Basic...

Rural Passenger Mobility in the 1990s: Emerging Local Solutions.

ERIC Educational Resources Information Center

Stommes, Eileen S.

1990-01-01

Describes current changes in rural transportation services. Describes general thrust of innovative efforts to provide rural passenger transportation despite declining resources. Describes public-private transportation cooperation, human-service agency coordination, linking state and local bus services, mixed passenger-package functions, community…

Protective Services for Abused and Neglected Children and Their Families. A Guide for State and Local Department of Public Social Services on the Delivery of Protective Services.

ERIC Educational Resources Information Center

Community Research Applications, Inc., New York, NY.

Provided is a guide to assist state and local agencies in improving the administration and management of services to abused and neglected children and their families. Protective services at the state level are covered in the first section, including such topics as organization; initiating and reacting to proposed state legislation; developing…

The Impact of Rural Non-Farm Residential Development on the Provision of Local Public Services. Iowa Land Use Research Report Series.

ERIC Educational Resources Information Center

Fisher, Peter S.

Using multiple regression analysis for each county and a case study of selected services in Johnson County, Iowa, the study estimated the impacts of rural non-farm development in Iowa on the demand for local public services, on the cost of providing these services, and on the distribution of service benefits and tax burdens among population…

Designing a podiatry service to meet the needs of the population: a service simulation.

PubMed

Campbell, Jackie A

2007-02-01

A model of a podiatry service has been developed which takes into consideration the effect of changing access criteria, skill mix and staffing levels (among others) given fixed local staffing budgets and the foot-health characteristics of the local community. A spreadsheet-based deterministic model was chosen to allow maximum transparency of programming. This work models a podiatry service in England, but could be adapted for other settings and, with some modification, for other community-based services. This model enables individual services to see the effect on outcome parameters such as number of patients treated, number discharged and size of waiting lists of various service configurations, given their individual local data profile. The process of designing the model has also had spin-off benefits for the participants in making explicit many of the implicit rules used in managing their services.

Attempts by one local health department to provide only essential public health services: a 10-year retrospective case study.

PubMed

Richardson, J Matthew; Pierce, J Rush; Lackan, Nuha

2012-01-01

Because of local political circumstances, in 1996, the local public health department in Amarillo, Texas, divested itself of almost all personal health services and chose to retain only essential population-based public health services. We analyzed function, funding, and staffing for various health department activities in FY 1997 and again in FY 2007. The figures were adjusted for inflation and population growth. We interviewed key personnel about the motivation and effects of the changes that occurred with this 10-year period. The local health department both transferred and reassumed some personal health services during this period. This was primarily in the area of immunization services and care for special population such as refugees. Public health preparedness also became a significant new area of activity. Most personal health services provided by the health department before 1996 remained the function of other health care entities in the community. When adjusted for inflation and population growth, most of the growth in the health department's personnel and budget was the result of state and federally mandated program changes. Growth in this local health department, which was committed to provide only essential health services, was driven primarily by state and federally mandated programs. Real growth for essential public health services did not occur over a 10-year period.

SHOCK CONNECTIVITY IN THE 2010 AUGUST AND 2012 JULY SOLAR ENERGETIC PARTICLE EVENTS INFERRED FROM OBSERVATIONS AND ENLIL MODELING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bain, H. M.; Luhmann, J. G.; Li, Y.

During periods of increased solar activity, coronal mass ejections (CMEs) can occur in close succession and proximity to one another. This can lead to the interaction and merger of CME ejecta as they propagate in the heliosphere. The particles accelerated in these shocks can result in complex solar energetic particle (SEP) events, as observing spacecraft form both remote and local shock connections. It can be challenging to understand these complex SEP events from in situ profiles alone. Multipoint observations of CMEs in the near-Sun environment, from the Solar Terrestrial Relations Observatory –Sun Earth Connection Coronal and Heliospheric Investigation and themore » Solar and Heliospheric Observatory Large Angle and Spectrometric Coronagraph, greatly improve our chances of identifying the origin of these accelerated particles. However, contextual information on conditions in the heliosphere, including the background solar wind conditions and shock structures, is essential for understanding SEP properties well enough to forecast their characteristics. Wang–Sheeley–Arge WSA-ENLIL + Cone modeling provides a tool to interpret major SEP event periods in the context of a realistic heliospheric model and to determine how much of what is observed in large SEP events depends on nonlocal magnetic connections to shock sources. We discuss observations of the SEP-rich periods of 2010 August and 2012 July in conjunction with ENLIL modeling. We find that much SEP activity can only be understood in the light of such models, and in particular from knowing about both remote and local shock source connections. These results must be folded into the investigations of the physics underlying the longitudinal extent of SEP events, and the source connection versus diffusion pictures of interpretations of SEP events.« less

Leakage current analysis for dislocations in Na-flux GaN bulk single crystals by conductive atomic force microscopy

NASA Astrophysics Data System (ADS)

Hamachi, T.; Takeuchi, S.; Tohei, T.; Imanishi, M.; Imade, M.; Mori, Y.; Sakai, A.

2018-04-01

The mechanisms associated with electrical conduction through individual threading dislocations (TDs) in a Na-flux GaN crystal grown with a multipoint-seed-GaN technique were investigated by conductive atomic force microscopy (C-AFM). To focus on individual TDs, dislocation-related etch pits (DREPs) were formed on the Na-flux GaN surface by wet chemical etching, after which microscopic Pt electrodes were locally fabricated on the DREPs to form conformal contacts to the Na-flux GaN crystal, using electron beam assisted deposition. The C-AFM data clearly demonstrate that the leakage current flows through the individual TD sites. It is also evident that the leakage current and the electrical conduction mechanism vary significantly based on the area within the Na-flux GaN crystal where the TDs are formed. These regions include the c-growth sector (cGS) in which the GaN grows in the [0001 ] direction on top of the point-seed with a c-plane growth front, the facet-growth sector (FGS) in which the GaN grows with {10 1 ¯ 1 } facets on the side of the cGS, the boundary region between the cGS and FGS (BR), and the coalescence boundary region between FGSs (CBR). The local current-voltage (I-V) characteristics of the specimen demonstrate space charge limited current conduction and conduction related to band-like trap states associated with TDs in the FGS, BR, and CBR. A detailed analysis of the I-V data indicates that the electrical conduction through TDs in the cGS may proceed via the Poole-Frenkel emission mechanism.

A composite experimental dynamic substructuring method based on partitioned algorithms and localized Lagrange multipliers

NASA Astrophysics Data System (ADS)

Abbiati, Giuseppe; La Salandra, Vincenzo; Bursi, Oreste S.; Caracoglia, Luca

2018-02-01

Successful online hybrid (numerical/physical) dynamic substructuring simulations have shown their potential in enabling realistic dynamic analysis of almost any type of non-linear structural system (e.g., an as-built/isolated viaduct, a petrochemical piping system subjected to non-stationary seismic loading, etc.). Moreover, owing to faster and more accurate testing equipment, a number of different offline experimental substructuring methods, operating both in time (e.g. the impulse-based substructuring) and frequency domains (i.e. the Lagrange multiplier frequency-based substructuring), have been employed in mechanical engineering to examine dynamic substructure coupling. Numerous studies have dealt with the above-mentioned methods and with consequent uncertainty propagation issues, either associated with experimental errors or modelling assumptions. Nonetheless, a limited number of publications have systematically cross-examined the performance of the various Experimental Dynamic Substructuring (EDS) methods and the possibility of their exploitation in a complementary way to expedite a hybrid experiment/numerical simulation. From this perspective, this paper performs a comparative uncertainty propagation analysis of three EDS algorithms for coupling physical and numerical subdomains with a dual assembly approach based on localized Lagrange multipliers. The main results and comparisons are based on a series of Monte Carlo simulations carried out on a five-DoF linear/non-linear chain-like systems that include typical aleatoric uncertainties emerging from measurement errors and excitation loads. In addition, we propose a new Composite-EDS (C-EDS) method to fuse both online and offline algorithms into a unique simulator. Capitalizing from the results of a more complex case study composed of a coupled isolated tank-piping system, we provide a feasible way to employ the C-EDS method when nonlinearities and multi-point constraints are present in the emulated system.

IRLT: Integrating Reputation and Local Trust for Trustworthy Service Recommendation in Service-Oriented Social Networks

PubMed Central

Liu, Zhiquan; Ma, Jianfeng; Jiang, Zhongyuan; Miao, Yinbin; Gao, Cong

2016-01-01

With the prevalence of Social Networks (SNs) and services, plenty of trust models for Trustworthy Service Recommendation (TSR) in Service-oriented SNs (S-SNs) have been proposed. The reputation-based schemes usually do not contain user preferences and are vulnerable to unfair rating attacks. Meanwhile, the local trust-based schemes generally have low reliability or even fail to work when the trust path is too long or does not exist. Thus it is beneficial to integrate them for TSR in S-SNs. This work improves the state-of-the-art Combining Global and Local Trust (CGLT) scheme and proposes a novel Integrating Reputation and Local Trust (IRLT) model which mainly includes four modules, namely Service Recommendation Interface (SRI) module, Local Trust-based Trust Evaluation (LTTE) module, Reputation-based Trust Evaluation (RTE) module and Aggregation Trust Evaluation (ATE) module. Besides, a synthetic S-SN based on the famous Advogato dataset is deployed and the well-known Discount Cumulative Gain (DCG) metric is employed to measure the service recommendation performance of our IRLT model with comparing to that of the excellent CGLT model. The results illustrate that our IRLT model is slightly superior to the CGLT model in honest environment and significantly outperforms the CGLT model in terms of the robustness against unfair rating attacks. PMID:26963089

IRLT: Integrating Reputation and Local Trust for Trustworthy Service Recommendation in Service-Oriented Social Networks.

PubMed

Liu, Zhiquan; Ma, Jianfeng; Jiang, Zhongyuan; Miao, Yinbin; Gao, Cong

2016-01-01

With the prevalence of Social Networks (SNs) and services, plenty of trust models for Trustworthy Service Recommendation (TSR) in Service-oriented SNs (S-SNs) have been proposed. The reputation-based schemes usually do not contain user preferences and are vulnerable to unfair rating attacks. Meanwhile, the local trust-based schemes generally have low reliability or even fail to work when the trust path is too long or does not exist. Thus it is beneficial to integrate them for TSR in S-SNs. This work improves the state-of-the-art Combining Global and Local Trust (CGLT) scheme and proposes a novel Integrating Reputation and Local Trust (IRLT) model which mainly includes four modules, namely Service Recommendation Interface (SRI) module, Local Trust-based Trust Evaluation (LTTE) module, Reputation-based Trust Evaluation (RTE) module and Aggregation Trust Evaluation (ATE) module. Besides, a synthetic S-SN based on the famous Advogato dataset is deployed and the well-known Discount Cumulative Gain (DCG) metric is employed to measure the service recommendation performance of our IRLT model with comparing to that of the excellent CGLT model. The results illustrate that our IRLT model is slightly superior to the CGLT model in honest environment and significantly outperforms the CGLT model in terms of the robustness against unfair rating attacks.

47 CFR 76.1616 - Contracts with local exchange carriers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 4 2012-10-01 2012-10-01 false Contracts with local exchange carriers. 76.1616 Section 76.1616 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1616 Contracts with local exchange carriers...