Sample records for set analysis gsa

  1. Evaluating Gene Set Enrichment Analysis Via a Hybrid Data Model

    PubMed Central

    Hua, Jianping; Bittner, Michael L.; Dougherty, Edward R.

    2014-01-01

    Gene set enrichment analysis (GSA) methods have been widely adopted by biological labs to analyze data and generate hypotheses for validation. Most of the existing comparison studies focus on whether the existing GSA methods can produce accurate P-values; however, practitioners are often more concerned with the correct gene-set ranking generated by the methods. The ranking performance is closely related to two critical goals associated with GSA methods: the ability to reveal biological themes and ensuring reproducibility, especially for small-sample studies. We have conducted a comprehensive simulation study focusing on the ranking performance of seven representative GSA methods. We overcome the limitation on the availability of real data sets by creating hybrid data models from existing large data sets. To build the data model, we pick a master gene from the data set to form the ground truth and artificially generate the phenotype labels. Multiple hybrid data models can be constructed from one data set and multiple data sets of smaller sizes can be generated by resampling the original data set. This approach enables us to generate a large batch of data sets to check the ranking performance of GSA methods. Our simulation study reveals that for the proposed data model, the Q2 type GSA methods have in general better performance than other GSA methods and the global test has the most robust results. The properties of a data set play a critical role in the performance. For the data sets with highly connected genes, all GSA methods suffer significantly in performance. PMID:24558298

  2. Performance Comparison of Two Gene Set Analysis Methods for Genome-wide Association Study Results: GSA-SNP vs i-GSEA4GWAS.

    PubMed

    Kwon, Ji-Sun; Kim, Jihye; Nam, Dougu; Kim, Sangsoo

    2012-06-01

    Gene set analysis (GSA) is useful in interpreting a genome-wide association study (GWAS) result in terms of biological mechanism. We compared the performance of two different GSA implementations that accept GWAS p-values of single nucleotide polymorphisms (SNPs) or gene-by-gene summaries thereof, GSA-SNP and i-GSEA4GWAS, under the same settings of inputs and parameters. GSA runs were made with two sets of p-values from a Korean type 2 diabetes mellitus GWAS study: 259,188 and 1,152,947 SNPs of the original and imputed genotype datasets, respectively. When Gene Ontology terms were used as gene sets, i-GSEA4GWAS produced 283 and 1,070 hits for the unimputed and imputed datasets, respectively. On the other hand, GSA-SNP reported 94 and 38 hits, respectively, for both datasets. Similar, but to a lesser degree, trends were observed with Kyoto Encyclopedia of Genes and Genomes (KEGG) gene sets as well. The huge number of hits by i-GSEA4GWAS for the imputed dataset was probably an artifact due to the scaling step in the algorithm. The decrease in hits by GSA-SNP for the imputed dataset may be due to the fact that it relies on Z-statistics, which is sensitive to variations in the background level of associations. Judicious evaluation of the GSA outcomes, perhaps based on multiple programs, is recommended.

  3. Time-Course Gene Set Analysis for Longitudinal Gene Expression Data

    PubMed Central

    Hejblum, Boris P.; Skinner, Jason; Thiébaut, Rodolphe

    2015-01-01

    Gene set analysis methods, which consider predefined groups of genes in the analysis of genomic data, have been successfully applied for analyzing gene expression data in cross-sectional studies. The time-course gene set analysis (TcGSA) introduced here is an extension of gene set analysis to longitudinal data. The proposed method relies on random effects modeling with maximum likelihood estimates. It allows to use all available repeated measurements while dealing with unbalanced data due to missing at random (MAR) measurements. TcGSA is a hypothesis driven method that identifies a priori defined gene sets with significant expression variations over time, taking into account the potential heterogeneity of expression within gene sets. When biological conditions are compared, the method indicates if the time patterns of gene sets significantly differ according to these conditions. The interest of the method is illustrated by its application to two real life datasets: an HIV therapeutic vaccine trial (DALIA-1 trial), and data from a recent study on influenza and pneumococcal vaccines. In the DALIA-1 trial TcGSA revealed a significant change in gene expression over time within 69 gene sets during vaccination, while a standard univariate individual gene analysis corrected for multiple testing as well as a standard a Gene Set Enrichment Analysis (GSEA) for time series both failed to detect any significant pattern change over time. When applied to the second illustrative data set, TcGSA allowed the identification of 4 gene sets finally found to be linked with the influenza vaccine too although they were found to be associated to the pneumococcal vaccine only in previous analyses. In our simulation study TcGSA exhibits good statistical properties, and an increased power compared to other approaches for analyzing time-course expression patterns of gene sets. The method is made available for the community through an R package. PMID:26111374

  4. GSA-PCA: gene set generation by principal component analysis of the Laplacian matrix of a metabolic network

    PubMed Central

    2012-01-01

    Background Gene Set Analysis (GSA) has proven to be a useful approach to microarray analysis. However, most of the method development for GSA has focused on the statistical tests to be used rather than on the generation of sets that will be tested. Existing methods of set generation are often overly simplistic. The creation of sets from individual pathways (in isolation) is a poor reflection of the complexity of the underlying metabolic network. We have developed a novel approach to set generation via the use of Principal Component Analysis of the Laplacian matrix of a metabolic network. We have analysed a relatively simple data set to show the difference in results between our method and the current state-of-the-art pathway-based sets. Results The sets generated with this method are semi-exhaustive and capture much of the topological complexity of the metabolic network. The semi-exhaustive nature of this method has also allowed us to design a hypergeometric enrichment test to determine which genes are likely responsible for set significance. We show that our method finds significant aspects of biology that would be missed (i.e. false negatives) and addresses the false positive rates found with the use of simple pathway-based sets. Conclusions The set generation step for GSA is often neglected but is a crucial part of the analysis as it defines the full context for the analysis. As such, set generation methods should be robust and yield as complete a representation of the extant biological knowledge as possible. The method reported here achieves this goal and is demonstrably superior to previous set analysis methods. PMID:22876834

  5. Gene set analysis approaches for RNA-seq data: performance evaluation and application guideline

    PubMed Central

    Rahmatallah, Yasir; Emmert-Streib, Frank

    2016-01-01

    Transcriptome sequencing (RNA-seq) is gradually replacing microarrays for high-throughput studies of gene expression. The main challenge of analyzing microarray data is not in finding differentially expressed genes, but in gaining insights into the biological processes underlying phenotypic differences. To interpret experimental results from microarrays, gene set analysis (GSA) has become the method of choice, in particular because it incorporates pre-existing biological knowledge (in a form of functionally related gene sets) into the analysis. Here we provide a brief review of several statistically different GSA approaches (competitive and self-contained) that can be adapted from microarrays practice as well as those specifically designed for RNA-seq. We evaluate their performance (in terms of Type I error rate, power, robustness to the sample size and heterogeneity, as well as the sensitivity to different types of selection biases) on simulated and real RNA-seq data. Not surprisingly, the performance of various GSA approaches depends only on the statistical hypothesis they test and does not depend on whether the test was developed for microarrays or RNA-seq data. Interestingly, we found that competitive methods have lower power as well as robustness to the samples heterogeneity than self-contained methods, leading to poor results reproducibility. We also found that the power of unsupervised competitive methods depends on the balance between up- and down-regulated genes in tested gene sets. These properties of competitive methods have been overlooked before. Our evaluation provides a concise guideline for selecting GSA approaches, best performing under particular experimental settings in the context of RNA-seq. PMID:26342128

  6. VARS-TOOL: A Comprehensive, Efficient, and Robust Sensitivity Analysis Toolbox

    NASA Astrophysics Data System (ADS)

    Razavi, S.; Sheikholeslami, R.; Haghnegahdar, A.; Esfahbod, B.

    2016-12-01

    VARS-TOOL is an advanced sensitivity and uncertainty analysis toolbox, applicable to the full range of computer simulation models, including Earth and Environmental Systems Models (EESMs). The toolbox was developed originally around VARS (Variogram Analysis of Response Surfaces), which is a general framework for Global Sensitivity Analysis (GSA) that utilizes the variogram/covariogram concept to characterize the full spectrum of sensitivity-related information, thereby providing a comprehensive set of "global" sensitivity metrics with minimal computational cost. VARS-TOOL is unique in that, with a single sample set (set of simulation model runs), it generates simultaneously three philosophically different families of global sensitivity metrics, including (1) variogram-based metrics called IVARS (Integrated Variogram Across a Range of Scales - VARS approach), (2) variance-based total-order effects (Sobol approach), and (3) derivative-based elementary effects (Morris approach). VARS-TOOL is also enabled with two novel features; the first one being a sequential sampling algorithm, called Progressive Latin Hypercube Sampling (PLHS), which allows progressively increasing the sample size for GSA while maintaining the required sample distributional properties. The second feature is a "grouping strategy" that adaptively groups the model parameters based on their sensitivity or functioning to maximize the reliability of GSA results. These features in conjunction with bootstrapping enable the user to monitor the stability, robustness, and convergence of GSA with the increase in sample size for any given case study. VARS-TOOL has been shown to achieve robust and stable results within 1-2 orders of magnitude smaller sample sizes (fewer model runs) than alternative tools. VARS-TOOL, available in MATLAB and Python, is under continuous development and new capabilities and features are forthcoming.

  7. Hidden drivers of low-dose pharmaceutical pollutant mixtures revealed by the novel GSA-QHTS screening method

    PubMed Central

    Rodea-Palomares, Ismael; Gonzalez-Pleiter, Miguel; Gonzalo, Soledad; Rosal, Roberto; Leganes, Francisco; Sabater, Sergi; Casellas, Maria; Muñoz-Carpena, Rafael; Fernández-Piñas, Francisca

    2016-01-01

    The ecological impacts of emerging pollutants such as pharmaceuticals are not well understood. The lack of experimental approaches for the identification of pollutant effects in realistic settings (that is, low doses, complex mixtures, and variable environmental conditions) supports the widespread perception that these effects are often unpredictable. To address this, we developed a novel screening method (GSA-QHTS) that couples the computational power of global sensitivity analysis (GSA) with the experimental efficiency of quantitative high-throughput screening (QHTS). We present a case study where GSA-QHTS allowed for the identification of the main pharmaceutical pollutants (and their interactions), driving biological effects of low-dose complex mixtures at the microbial population level. The QHTS experiments involved the integrated analysis of nearly 2700 observations from an array of 180 unique low-dose mixtures, representing the most complex and data-rich experimental mixture effect assessment of main pharmaceutical pollutants to date. An ecological scaling-up experiment confirmed that this subset of pollutants also affects typical freshwater microbial community assemblages. Contrary to our expectations and challenging established scientific opinion, the bioactivity of the mixtures was not predicted by the null mixture models, and the main drivers that were identified by GSA-QHTS were overlooked by the current effect assessment scheme. Our results suggest that current chemical effect assessment methods overlook a substantial number of ecologically dangerous chemical pollutants and introduce a new operational framework for their systematic identification. PMID:27617294

  8. Three α-Subunits of Heterotrimeric G Proteins and an Adenylyl Cyclase Have Distinct Roles in Fruiting Body Development in the Homothallic Fungus Sordaria macrospora

    PubMed Central

    Kamerewerd, Jens; Jansson, Malin; Nowrousian, Minou; Pöggeler, Stefanie; Kück, Ulrich

    2008-01-01

    Sordaria macrospora, a self-fertile filamentous ascomycete, carries genes encoding three different α-subunits of heterotrimeric G proteins (gsa, G protein Sordaria alpha subunit). We generated knockout strains for all three gsa genes (Δgsa1, Δgsa2, and Δgsa3) as well as all combinations of double mutants. Phenotypic analysis of single and double mutants showed that the genes for Gα-subunits have distinct roles in the sexual life cycle. While single mutants show some reduction of fertility, double mutants Δgsa1Δgsa2 and Δgsa1Δgsa3 are completely sterile. To test whether the pheromone receptors PRE1 and PRE2 mediate signaling via distinct Gα-subunits, two recently generated Δpre strains were crossed with all Δgsa strains. Analyses of the corresponding double mutants revealed that compared to GSA2, GSA1 is a more predominant regulator of a signal transduction cascade downstream of the pheromone receptors and that GSA3 is involved in another signaling pathway that also contributes to fruiting body development and fertility. We further isolated the gene encoding adenylyl cyclase (AC) (sac1) for construction of a knockout strain. Analyses of the three ΔgsaΔsac1 double mutants and one Δgsa2Δgsa3Δsac1 triple mutant indicate that SAC1 acts downstream of GSA3, parallel to a GSA1–GSA2-mediated signaling pathway. In addition, the function of STE12 and PRO41, two presumptive signaling components, was investigated in diverse double mutants lacking those developmental genes in combination with the gsa genes. This analysis was further completed by expression studies of the ste12 and pro41 transcripts in wild-type and mutant strains. From the sum of all our data, we propose a model for how different Gα-subunits interact with pheromone receptors, adenylyl cyclase, and STE12 and thus cooperatively regulate sexual development in S. macrospora. PMID:18723884

  9. Stochastic Leader Gravitational Search Algorithm for Enhanced Adaptive Beamforming Technique

    PubMed Central

    Darzi, Soodabeh; Islam, Mohammad Tariqul; Tiong, Sieh Kiong; Kibria, Salehin; Singh, Mandeep

    2015-01-01

    In this paper, stochastic leader gravitational search algorithm (SL-GSA) based on randomized k is proposed. Standard GSA (SGSA) utilizes the best agents without any randomization, thus it is more prone to converge at suboptimal results. Initially, the new approach randomly choses k agents from the set of all agents to improve the global search ability. Gradually, the set of agents is reduced by eliminating the agents with the poorest performances to allow rapid convergence. The performance of the SL-GSA was analyzed for six well-known benchmark functions, and the results are compared with SGSA and some of its variants. Furthermore, the SL-GSA is applied to minimum variance distortionless response (MVDR) beamforming technique to ensure compatibility with real world optimization problems. The proposed algorithm demonstrates superior convergence rate and quality of solution for both real world problems and benchmark functions compared to original algorithm and other recent variants of SGSA. PMID:26552032

  10. Gram staining apparatus for space station applications

    NASA Technical Reports Server (NTRS)

    Molina, T. C.; Brown, H. D.; Irbe, R. M.; Pierson, D. L.

    1990-01-01

    A self-contained, portable Gram staining apparatus (GSA) has been developed for use in the microgravity environment on board the Space Station Freedom. Accuracy and reproducibility of this apparatus compared with the conventional Gram staining method were evaluated by using gram-negative and gram-positive controls and different species of bacteria grown in pure cultures. A subsequent study was designed to assess the performance of the GSA with actual specimens. A set of 60 human and environmental specimens was evaluated with the GSA and the conventional Gram staining procedure. Data obtained from these studies indicated that the GSA will provide the Gram staining capability needed for the microgravity environment of space.

  11. Genome-Wide Gene Set Analysis for Identification of Pathways Associated with Alcohol Dependence

    PubMed Central

    Biernacka, Joanna M.; Geske, Jennifer; Jenkins, Gregory D.; Colby, Colin; Rider, David N.; Karpyak, Victor M.; Choi, Doo-Sup; Fridley, Brooke L.

    2013-01-01

    It is believed that multiple genetic variants with small individual effects contribute to the risk of alcohol dependence. Such polygenic effects are difficult to detect in genome-wide association studies that test for association of the phenotype with each single nucleotide polymorphism (SNP) individually. To overcome this challenge, gene set analysis (GSA) methods that jointly test for the effects of pre-defined groups of genes have been proposed. Rather than testing for association between the phenotype and individual SNPs, these analyses evaluate the global evidence of association with a set of related genes enabling the identification of cellular or molecular pathways or biological processes that play a role in development of the disease. It is hoped that by aggregating the evidence of association for all available SNPs in a group of related genes, these approaches will have enhanced power to detect genetic associations with complex traits. We performed GSA using data from a genome-wide study of 1165 alcohol dependent cases and 1379 controls from the Study of Addiction: Genetics and Environment (SAGE), for all 200 pathways listed in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Results demonstrated a potential role of the “Synthesis and Degradation of Ketone Bodies” pathway. Our results also support the potential involvement of the “Neuroactive Ligand Receptor Interaction” pathway, which has previously been implicated in addictive disorders. These findings demonstrate the utility of GSA in the study of complex disease, and suggest specific directions for further research into the genetic architecture of alcohol dependence. PMID:22717047

  12. Gram staining apparatus for space station applications.

    PubMed Central

    Molina, T C; Brown, H D; Irbe, R M; Pierson, D L

    1990-01-01

    A self-contained, portable Gram staining apparatus (GSA) has been developed for use in the microgravity environment on board the Space Station Freedom. Accuracy and reproducibility of this apparatus compared with the conventional Gram staining method were evaluated by using gram-negative and gram-positive controls and different species of bacteria grown in pure cultures. A subsequent study was designed to assess the performance of the GSA with actual specimens. A set of 60 human and environmental specimens was evaluated with the GSA and the conventional Gram staining procedure. Data obtained from these studies indicated that the GSA will provide the Gram staining capability needed for the microgravity environment of space. Images PMID:1690529

  13. Global Sensitivity Analysis as Good Modelling Practices tool for the identification of the most influential process parameters of the primary drying step during freeze-drying.

    PubMed

    Van Bockstal, Pieter-Jan; Mortier, Séverine Thérèse F C; Corver, Jos; Nopens, Ingmar; Gernaey, Krist V; De Beer, Thomas

    2018-02-01

    Pharmaceutical batch freeze-drying is commonly used to improve the stability of biological therapeutics. The primary drying step is regulated by the dynamic settings of the adaptable process variables, shelf temperature T s and chamber pressure P c . Mechanistic modelling of the primary drying step leads to the optimal dynamic combination of these adaptable process variables in function of time. According to Good Modelling Practices, a Global Sensitivity Analysis (GSA) is essential for appropriate model building. In this study, both a regression-based and variance-based GSA were conducted on a validated mechanistic primary drying model to estimate the impact of several model input parameters on two output variables, the product temperature at the sublimation front T i and the sublimation rate ṁ sub . T s was identified as most influential parameter on both T i and ṁ sub , followed by P c and the dried product mass transfer resistance α Rp for T i and ṁ sub , respectively. The GSA findings were experimentally validated for ṁ sub via a Design of Experiments (DoE) approach. The results indicated that GSA is a very useful tool for the evaluation of the impact of different process variables on the model outcome, leading to essential process knowledge, without the need for time-consuming experiments (e.g., DoE). Copyright © 2017 Elsevier B.V. All rights reserved.

  14. 75 FR 57062 - Proposed Collection of Information; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... procedures. The delegation includes specific terms and conditions and is subject to the terms and conditions set forth in the ``Standard Operating Procedures for Delegated Government-Owned Real Property'' ``SOP... Administration and Management (OASAM) operates the FPB under a 2003 delegation from GSA; the existing GSA-DOL...

  15. 75 FR 77727 - Federal Acquisition Regulation; HUBZone Program Revisions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ... (NASA). ACTION: Final rule. SUMMARY: The Civilian Agency Acquisition Council and the Defense Acquisition... Case 2006-005. SUPPLEMENTARY INFORMATION: A. Background DoD, GSA, and NASA published a proposed rule in..., Acquisition Policy Division. 0 Therefore, DoD, GSA, and NASA amend 48 CFR parts 2, 19, 33, and 52 as set forth...

  16. 41 CFR 101-26.501-7 - Sale of vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Sale of vehicles. 101-26... PROGRAM 26.5-GSA Procurement Programs § 101-26.501-7 Sale of vehicles. GSA will not solicit trade-in bids... that are being replaced will be disposed of by sale as set forth in Part 101-46. [57 FR 47779, Oct. 20...

  17. 41 CFR 101-26.501-7 - Sale of vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Sale of vehicles. 101-26... PROGRAM 26.5-GSA Procurement Programs § 101-26.501-7 Sale of vehicles. GSA will not solicit trade-in bids... that are being replaced will be disposed of by sale as set forth in Part 101-46. [57 FR 47779, Oct. 20...

  18. Sharing tools and best practice in Global Sensitivity Analysis within academia and with industry

    NASA Astrophysics Data System (ADS)

    Wagener, T.; Pianosi, F.; Noacco, V.; Sarrazin, F.

    2017-12-01

    We have spent years trying to improve the use of global sensitivity analysis (GSA) in earth and environmental modelling. Our efforts included (1) the development of tools that provide easy access to widely used GSA methods, (2) the definition of workflows so that best practice is shared in an accessible way, and (3) the development of algorithms to close gaps in available GSA methods (such as moment independent strategies) and to make GSA applications more robust (such as convergence criteria). These elements have been combined in our GSA Toolbox, called SAFE (www.safetoolbox.info), which has up to now been adopted by over 1000 (largely) academic users worldwide. However, despite growing uptake in academic circles and across a wide range of application areas, transfer to industry applications has been difficult. Initial market research regarding opportunities and barriers for uptake revealed a large potential market, but also highlighted a significant lack of knowledge regarding state-of-the-art methods and their potential value for end-users. We will present examples and discuss our experience so far in trying to overcome these problems and move beyond academia in distributing GSA tools and expertise.

  19. Random forests-based differential analysis of gene sets for gene expression data.

    PubMed

    Hsueh, Huey-Miin; Zhou, Da-Wei; Tsai, Chen-An

    2013-04-10

    In DNA microarray studies, gene-set analysis (GSA) has become the focus of gene expression data analysis. GSA utilizes the gene expression profiles of functionally related gene sets in Gene Ontology (GO) categories or priori-defined biological classes to assess the significance of gene sets associated with clinical outcomes or phenotypes. Many statistical approaches have been proposed to determine whether such functionally related gene sets express differentially (enrichment and/or deletion) in variations of phenotypes. However, little attention has been given to the discriminatory power of gene sets and classification of patients. In this study, we propose a method of gene set analysis, in which gene sets are used to develop classifications of patients based on the Random Forest (RF) algorithm. The corresponding empirical p-value of an observed out-of-bag (OOB) error rate of the classifier is introduced to identify differentially expressed gene sets using an adequate resampling method. In addition, we discuss the impacts and correlations of genes within each gene set based on the measures of variable importance in the RF algorithm. Significant classifications are reported and visualized together with the underlying gene sets and their contribution to the phenotypes of interest. Numerical studies using both synthesized data and a series of publicly available gene expression data sets are conducted to evaluate the performance of the proposed methods. Compared with other hypothesis testing approaches, our proposed methods are reliable and successful in identifying enriched gene sets and in discovering the contributions of genes within a gene set. The classification results of identified gene sets can provide an valuable alternative to gene set testing to reveal the unknown, biologically relevant classes of samples or patients. In summary, our proposed method allows one to simultaneously assess the discriminatory ability of gene sets and the importance of genes for interpretation of data in complex biological systems. The classifications of biologically defined gene sets can reveal the underlying interactions of gene sets associated with the phenotypes, and provide an insightful complement to conventional gene set analyses. Copyright © 2012 Elsevier B.V. All rights reserved.

  20. RAMPART (TM): Risk Assessment Method-Property Analysis and Ranking Tool v.4.0

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carson, Susan D.; Hunter, Regina L.; Link, Madison D.

    RAMPART{trademark}, Risk Assessment Method-property Analysis and Ranking Tool, is a new type of computer software package for the assessment of risk to buildings. RAMPART{trademark} has been developed by Sandia National Laboratories (SNL) for the U.S. General Services Administration (GSA). RAMPART {trademark} has been designed and developed to be a risk-based decision support tool that requires no risk analysis expertise on the part of the user. The RAMPART{trademark} user interface elicits information from the user about the building. The RAMPART{trademark} expert system is a set of rules that embodies GSA corporate knowledge and SNL's risk assessment experience. The RAMPART{trademark} database containsmore » both data entered by the user during a building analysis session and large sets of natural hazard and crime data. RAMPART{trademark} algorithms use these data to assess the risk associated with a given building in the face of certain hazards. Risks arising from five natural hazards (earthquake, hurricane, winter storm, tornado and flood); crime (inside and outside the building); fire and terrorism are calculated. These hazards may cause losses of various kinds. RAMPART{trademark} considers death, injury, loss of mission, loss of property, loss of contents, loss of building use, and first-responder loss. The results of each analysis are presented graphically on the screen and in a written report.« less

  1. Three alpha-subunits of heterotrimeric G proteins and an adenylyl cyclase have distinct roles in fruiting body development in the homothallic fungus Sordaria macrospora.

    PubMed

    Kamerewerd, Jens; Jansson, Malin; Nowrousian, Minou; Pöggeler, Stefanie; Kück, Ulrich

    2008-09-01

    Sordaria macrospora, a self-fertile filamentous ascomycete, carries genes encoding three different alpha-subunits of heterotrimeric G proteins (gsa, G protein Sordaria alpha subunit). We generated knockout strains for all three gsa genes (Deltagsa1, Deltagsa2, and Deltagsa3) as well as all combinations of double mutants. Phenotypic analysis of single and double mutants showed that the genes for Galpha-subunits have distinct roles in the sexual life cycle. While single mutants show some reduction of fertility, double mutants Deltagsa1Deltagsa2 and Deltagsa1Deltagsa3 are completely sterile. To test whether the pheromone receptors PRE1 and PRE2 mediate signaling via distinct Galpha-subunits, two recently generated Deltapre strains were crossed with all Deltagsa strains. Analyses of the corresponding double mutants revealed that compared to GSA2, GSA1 is a more predominant regulator of a signal transduction cascade downstream of the pheromone receptors and that GSA3 is involved in another signaling pathway that also contributes to fruiting body development and fertility. We further isolated the gene encoding adenylyl cyclase (AC) (sac1) for construction of a knockout strain. Analyses of the three DeltagsaDeltasac1 double mutants and one Deltagsa2Deltagsa3Deltasac1 triple mutant indicate that SAC1 acts downstream of GSA3, parallel to a GSA1-GSA2-mediated signaling pathway. In addition, the function of STE12 and PRO41, two presumptive signaling components, was investigated in diverse double mutants lacking those developmental genes in combination with the gsa genes. This analysis was further completed by expression studies of the ste12 and pro41 transcripts in wild-type and mutant strains. From the sum of all our data, we propose a model for how different Galpha-subunits interact with pheromone receptors, adenylyl cyclase, and STE12 and thus cooperatively regulate sexual development in S. macrospora.

  2. The Potential to Promote Resilience: Piloting a Minority Stress-Informed, GSA-Based, Mental Health Promotion Program for LGBTQ Youth

    PubMed Central

    Heck, Nicholas C.

    2015-01-01

    This article describes the results of a pilot study to determine the feasibility and acceptability of a mental health promotion program that was developed to address minority stressors and promote coping skills among lesbian, gay, bisexual, transgender, and queer (LGBTQ) youth. It was hypothesized that the program would be feasible to implement within the context of a gay-straight alliance (GSA) and that GSA members would find the program acceptable (e.g., educational, enjoyable, helpful, and relevant). Participants included ten members of a high school GSA in the northeastern United States. The program sessions were delivered during GSA meetings. The first session emphasized the identification of minority and general stressors, which was followed by a discussion of coping strategies. The remaining sessions emphasized the development of cognitive coping, affect regulation, and problem-solving skills. After each session, participants completed a 13-item feedback form. Ten items assessed acceptability and three open-ended items allowed participants to provide constructive feedback. Although the program was feasible to implement within the GSA setting, attendance at the sessions was variable. Those who attended the sessions reported them to be enjoyable, informative, relevant to their lives, and potentially helpful for other LGBTQ students. After revising the program, future research is needed to investigate its dissemination potential and determine whether the program can disrupt the minority stress-psychiatric distress relationship. PMID:26366425

  3. The Potential to Promote Resilience: Piloting a Minority Stress-Informed, GSA-Based, Mental Health Promotion Program for LGBTQ Youth.

    PubMed

    Heck, Nicholas C

    2015-09-01

    This article describes the results of a pilot study to determine the feasibility and acceptability of a mental health promotion program that was developed to address minority stressors and promote coping skills among lesbian, gay, bisexual, transgender, and queer (LGBTQ) youth. It was hypothesized that the program would be feasible to implement within the context of a gay-straight alliance (GSA) and that GSA members would find the program acceptable (e.g., educational, enjoyable, helpful, and relevant). Participants included ten members of a high school GSA in the northeastern United States. The program sessions were delivered during GSA meetings. The first session emphasized the identification of minority and general stressors, which was followed by a discussion of coping strategies. The remaining sessions emphasized the development of cognitive coping, affect regulation, and problem-solving skills. After each session, participants completed a 13-item feedback form. Ten items assessed acceptability and three open-ended items allowed participants to provide constructive feedback. Although the program was feasible to implement within the GSA setting, attendance at the sessions was variable. Those who attended the sessions reported them to be enjoyable, informative, relevant to their lives, and potentially helpful for other LGBTQ students. After revising the program, future research is needed to investigate its dissemination potential and determine whether the program can disrupt the minority stress-psychiatric distress relationship.

  4. 48 CFR 339.7002 - Notice of intended award.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... approval to make an award to other than a GSA BPA holder for independent risk analysis services and either..., the CAO, or designee, shall send a notice of intended award to the designated GSA BPA Contracting...

  5. 48 CFR 339.7002 - Notice of intended award.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... approval to make an award to other than a GSA BPA holder for independent risk analysis services and either..., the CAO, or designee, shall send a notice of intended award to the designated GSA BPA Contracting...

  6. 48 CFR 339.7002 - Notice of intended award.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... approval to make an award to other than a GSA BPA holder for independent risk analysis services and either..., the CAO, or designee, shall send a notice of intended award to the designated GSA BPA Contracting...

  7. 48 CFR 339.7002 - Notice of intended award.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... approval to make an award to other than a GSA BPA holder for independent risk analysis services and either..., the CAO, or designee, shall send a notice of intended award to the designated GSA BPA Contracting...

  8. 48 CFR 339.7002 - Notice of intended award.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... approval to make an award to other than a GSA BPA holder for independent risk analysis services and either..., the CAO, or designee, shall send a notice of intended award to the designated GSA BPA Contracting...

  9. Gay-Straight Alliance Involvement and Youths' Participation in Civic Engagement, Advocacy, and Awareness-Raising.

    PubMed

    Poteat, V Paul; Calzo, Jerel P; Yoshikawa, Hirokazu

    2018-01-01

    Civic engagement among lesbian, gay, bisexual, transgender, or questioning (LGBTQ) youth and heterosexual cisgender allies can challenge oppressive systems. Among 295 youth in 33 Gay-Straight Alliances (GSAs; 69% LGBQ, 68% cisgender female, 68% white, M age = 16.07), we examined whether greater GSA involvement was associated with greater general civic engagement, as well as participation in greater LGBTQ-specific advocacy and awareness-raising efforts. Further, we tested whether these associations were partly mediated through members' sense of agency. Greater GSA involvement was associated with greater civic engagement, advocacy, and awareness-raising; associations did not differ based on sexual orientation or gender identity. Finally, the association between GSA involvement and civic engagement was partially mediated through youths' greater sense of agency. Agency did not mediate the association between GSA involvement and engagement in advocacy or awareness-raising efforts. The results suggest GSAs are settings with potential to foster students' capacity to be active and engaged citizens.

  10. Global Sensitivity Analysis of Environmental Systems via Multiple Indices based on Statistical Moments of Model Outputs

    NASA Astrophysics Data System (ADS)

    Guadagnini, A.; Riva, M.; Dell'Oca, A.

    2017-12-01

    We propose to ground sensitivity of uncertain parameters of environmental models on a set of indices based on the main (statistical) moments, i.e., mean, variance, skewness and kurtosis, of the probability density function (pdf) of a target model output. This enables us to perform Global Sensitivity Analysis (GSA) of a model in terms of multiple statistical moments and yields a quantification of the impact of model parameters on features driving the shape of the pdf of model output. Our GSA approach includes the possibility of being coupled with the construction of a reduced complexity model that allows approximating the full model response at a reduced computational cost. We demonstrate our approach through a variety of test cases. These include a commonly used analytical benchmark, a simplified model representing pumping in a coastal aquifer, a laboratory-scale tracer experiment, and the migration of fracturing fluid through a naturally fractured reservoir (source) to reach an overlying formation (target). Our strategy allows discriminating the relative importance of model parameters to the four statistical moments considered. We also provide an appraisal of the error associated with the evaluation of our sensitivity metrics by replacing the original system model through the selected surrogate model. Our results suggest that one might need to construct a surrogate model with increasing level of accuracy depending on the statistical moment considered in the GSA. The methodological framework we propose can assist the development of analysis techniques targeted to model calibration, design of experiment, uncertainty quantification and risk assessment.

  11. 75 FR 21899 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ....regulations.gov. FOR FURTHER INFORMATION CONTACT: Hada Flowers, Supervisor, Regulatory Secretariat Branch... Flexibility Analysis Required: Yes Agency Contact: Hada Flowers, Supervisor, Regulatory Secretariat, DOD/ GSA... Email: hada.flowers@gsa.gov RIN: 9000-AK92 301. FAR CASE 2006-005, HUBZONE PROGRAM REVISIONS Legal...

  12. Greater Engagement Among Members of Gay-Straight Alliances: Individual and Structural Contributors

    PubMed Central

    Poteat, V. Paul; Heck, Nicholas C.; Yoshikawa, Hirokazu; Calzo, Jerel P.

    2017-01-01

    Using youth program models to frame the study of Gay-Straight Alliances (GSAs), we identified individual and structural predictors of greater engagement in these settings with a cross-sectional sample of 295 youth in 33 GSAs from the 2014 Massachusetts GSA Network Survey (69% LGBQ, 68% cisgen-der female, 68% White, Mage = 16.07). Multilevel modeling results indicated that members who perceived more support/socializing from their GSA, had more LGB friends, were longer serving members, and were in GSAs with more open and respectful climates reported greater engagement. Further, there was a curvilinear association between organizational structure in the GSA and engagement: Perceptions of more structure were associated with greater engagement to a point, after which greater structure was related to less engagement. PMID:28757649

  13. Department of Defense / General Services Administration / National Aeronautics and Space...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ....regulations.gov . FOR FURTHER INFORMATION CONTACT: Hada Flowers, Supervisor, Regulatory Secretariat Branch... Flexibility Analysis Required: Yes Agency Contact: Hada Flowers, Supervisor, Regulatory Secretariat, DOD/ GSA... Email: hada.flowers@gsa.gov RIN: 9000-AK92 301. FAR CASE 2006-005, HUBZONE PROGRAM REVISIONS Legal...

  14. Federal Catalog System Policy Manual

    DTIC Science & Technology

    1975-03-01

    Television GSA 75 B 7ype S,-,o.!) Rc-cords GSA 75 B -c and Sporting Equipment GSA 75 B Yoys, and Wheeled Goods GSA 75 B L.-• rla: and Gymnastic Equipment...B Sr .-tions tt: Dopes., Varnishes and Related GSA 75 B ct 1. s .. ,c Artists ’ Brushes GSA 75 BSr-’,aJive and Sealing Coiapound GSA 75 B GSA 75 B I

  15. Preparation for implementation of the mechanistic-empirical pavement design guide in Michigan : part 2 - evaluation of rehabilitation fixes (part 2).

    DOT National Transportation Integrated Search

    2013-08-01

    The overall goal of Global Sensitivity Analysis (GSA) is to determine sensitivity of pavement performance prediction models to the variation in the design input values. The main difference between GSA and detailed sensitivity analyses is the way the ...

  16. Genetic analysis of the gravitropic set-point angle in lateral roots of Arabidopsis

    NASA Technical Reports Server (NTRS)

    Mullen, J. L.; Hangarter, R. P.; Kiss, J. Z. (Principal Investigator)

    2003-01-01

    Research on gravity responses in plants has mostly focused on primary roots and shoots, which typically orient to a vertical orientation. However, the distribution of lateral organs and their characteristically non-vertical growth orientation are critical for the determination of plant form. For example, in Arabidopsis, when lateral roots emerge from the primary root, they grow at a nearly horizontal orientation. As they elongate, the roots slowly curve until they eventually reach a vertical orientation. The regulation of this lateral root orientation is an important component affecting overall root system architecture. We found that this change in orientation is not simply due to the onset of gravitropic competence, as non-vertical lateral roots are capable of both positive and negative gravitropism. Thus, the horizontal growth of new lateral roots appears to be determined by what is called the gravitropic set-point angle (GSA). This developmental control of the GSA of lateral roots in Arabidopsis provides a useful system for investigating the components involved in regulating gravitropic responses. Using this system, we have identified several Arabidopsis mutants that have altered lateral root orientations but maintain normal primary root orientation. c2003 COSPAR. Published by Elsevier Ltd. All rights reserved.

  17. Defense Integrated Materiel Management Manual for Consumable Items

    DTIC Science & Technology

    1992-01-01

    GSA 7830 Recreational and Gymnastic Equipment GSA A-1-14 DoD 4140.26-K 7910 Floor Polishers and Vacuum Cleaning Equipment GSA 7920 Brooms, Brushes, Mops... Artists ’ Brushes GSA 8030 Preservative and Sealing Compounds GSA 8040 Adhesives GSA 8105 Bags and Sacks GSA 8110 Drums and Cans DGSC 8115 Boxes, Cartons

  18. 41 CFR 101-26.506-1 - Types of service.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Types of service. 101-26... PROGRAM 26.5-GSA Procurement Programs § 101-26.506-1 Types of service. GSA interior planning and design services consist of data gathering and organizational analysis; development of a space requirements program...

  19. 41 CFR 101-26.506-1 - Types of service.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Types of service. 101-26... PROGRAM 26.5-GSA Procurement Programs § 101-26.506-1 Types of service. GSA interior planning and design services consist of data gathering and organizational analysis; development of a space requirements program...

  20. 48 CFR 8.402 - General.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... System.) Ordering activities may access GSA Advantage! through the GSA Federal Supply Service Home Page (http://www.gsa.gov/fss) or the GSA Federal Supply Schedule Home Page at http://www.gsa.gov/schedules..., review the following Web site: http://www.gsa.gov/schedules. Additionally, for on-line training courses...

  1. 41 CFR 101-30.603 - GSA Supply Catalog.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603 GSA Supply Catalog. (a) The GSA Supply... GSA Supply Catalog contains all necessary information for ordering from the GSA Federal Supply Service...

  2. 41 CFR 101-30.603 - GSA Supply Catalog.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603 GSA Supply Catalog. (a) The GSA Supply... GSA Supply Catalog contains all necessary information for ordering from the GSA Federal Supply Service...

  3. 41 CFR 101-30.603 - GSA Supply Catalog.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603 GSA Supply Catalog. (a) The GSA Supply... GSA Supply Catalog contains all necessary information for ordering from the GSA Federal Supply Service...

  4. 41 CFR 101-30.603 - GSA Supply Catalog.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603 GSA Supply Catalog. (a) The GSA Supply... GSA Supply Catalog contains all necessary information for ordering from the GSA Federal Supply Service...

  5. 41 CFR 101-30.603 - GSA Supply Catalog.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603 GSA Supply Catalog. (a) The GSA Supply... GSA Supply Catalog contains all necessary information for ordering from the GSA Federal Supply Service...

  6. Hydrogeologic and hydraulic characterization of aquifer and nonaquifer layers in a lateritic terrain (West Bengal, India)

    NASA Astrophysics Data System (ADS)

    Biswal, Sabinaya; Jha, Madan K.; Sharma, Shashi P.

    2018-02-01

    The hydrogeologic and hydraulic characteristics of a lateritic terrain in West Bengal, India, were investigated. Test drilling was conducted at ten sites and grain-size distribution curves (GSDCs) were prepared for 275 geologic samples. Performance evaluation of eight grain-size-analysis (GSA) methods was carried out to estimate the hydraulic conductivity (K) of subsurface formations. Finally, the GSA results were validated against pumping-test data. The GSDCs indicated that shallow aquifer layers are coarser than the deeper aquifer layers (uniformity coefficient 0.19-11.4). Stratigraphy analysis revealed that both shallow and deep aquifers of varying thickness exist at depths 9-40 and 40-79 m, respectively. The mean K estimates by the GSA methods are 3.62-292.86 m/day for shallow aquifer layers and 0.97-209.93 m/day for the deeper aquifer layers, suggesting significant aquifer heterogeneity. Pumping-test data indicated that the deeper aquifers are leaky confined with transmissivity 122.69-693.79 m2/day, storage coefficient 1.01 × 10-7-2.13 × 10-4 and leakance 2.01 × 10-7-34.56 × 10-2 day-1. Although the K values yielded by the GSA methods are generally larger than those obtained from the pumping tests, the Slichter, Harleman and US Bureau Reclamation (USBR) GSA methods yielded reasonable values at most of the sites (1-3 times higher than K estimates by the pumping-test method). In conclusion, more reliable aquifers exist at deeper depths that can be tapped for dependable water supply. GSA methods such as Slichter, Harleman and USBR can be used for the preliminary assessment of K in lateritic terrains in the absence of reliable field methods.

  7. The Clean Coal Technology Program 100 MWe demonstration of gas suspension absorption for flue gas desulfurization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hsu, F.E.; Hedenhag, J.G.; Marchant, S.K.

    1997-12-31

    AirPol Inc., with the cooperation of the Tennessee Valley Authority (TVA) under a Cooperative Agreement with the United States Department of Energy, installed and tested a 10 MWe Gas Suspension Absorption (GSA) Demonstration system at TVA`s Shawnee Fossil Plant near Paducah, Kentucky. This low-cost retrofit project demonstrated that the GSA system can remove more than 90% of the sulfur dioxide from high-sulfur coal-fired flue gas, while achieving a relatively high utilization of reagent lime. This paper presents a detailed technical description of the Clean Coal Technology demonstration project. Test results and data analysis from the preliminary testing, factorial tests, airmore » toxics texts, 28-day continuous demonstration run of GSA/electrostatic precipitator (ESP), and 14-day continuous demonstration run of GSA/pulse jet baghouse (PJBH) are also discussed within this paper.« less

  8. Getting Geology Students Into the Field

    NASA Astrophysics Data System (ADS)

    Nocerino, J.

    2011-12-01

    The importance of field schools to practicing geologists is unquestionable; yet, the opportunities to experience field geology are dwindling. The Geological Society of America (GSA), in cooperation with ExxonMobil, are currently offering three programs to support and encourage field geology. The GSA/ExxonMobil Bighorn Basin Field award is a field seminar in the Bighorn Basin of north-central Wyoming emphasizing multi-disciplinary integrated basin analysis. The GSA/ExxonMobil Field Camp Scholar Award provides undergraduate students 2,000 each to attend the field camp of their choice based on diversity, economic/financial need, and merit. Finally, the GSA/ExxonMobil Field Camp Excellence Award provides one geologic field camp leader an award of 10,000 to assist with their summer field camp season based on safety awareness, diversity, and technical excellence. This non-profit/industry collaboration has proven very successful and in 2011 over 300 geology students and professors have applied for these awards.

  9. 41 CFR 101-30.303 - Responsibility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... direct to the Defense Logistics Services Center (DLSC) in conformance with procedures set forth in the... cataloging activity designated to receive requests are in the GSA Handbook, Federal Catalog System-Logistics...

  10. 41 CFR 101-30.303 - Responsibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... direct to the Defense Logistics Services Center (DLSC) in conformance with procedures set forth in the... cataloging activity designated to receive requests are in the GSA Handbook, Federal Catalog System-Logistics...

  11. 41 CFR 101-30.303 - Responsibility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... direct to the Defense Logistics Services Center (DLSC) in conformance with procedures set forth in the... cataloging activity designated to receive requests are in the GSA Handbook, Federal Catalog System-Logistics...

  12. Amazon Business And GSA Advantage: A Comparative Analysis

    DTIC Science & Technology

    2017-12-01

    training for businesses or a customer -ordering guide; however, the site does offer a help center where businesses and users can submit questions...Electronic Offer FAR Federal Acquisition Regulation FAS Federal Acquisition Service FASA Federal Acquisition Streamlining Act FGO Field Grade Officer...component of GSA Advantage, is an online procurement tool that allows customers to request quotes for (1) commercial supplies and services under

  13. 41 CFR 105-54.401 - Reports on GSA Federal Advisory Committees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... fiscal year report to the Congress. Instructions for preparing GSA's submission are provided by the GSA... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Reports on GSA Federal... Services Administration 54-ADVISORY COMMITTEE MANAGEMENT 54.4-Reports § 105-54.401 Reports on GSA Federal...

  14. 41 CFR 105-54.401 - Reports on GSA Federal Advisory Committees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... fiscal year report to the Congress. Instructions for preparing GSA's submission are provided by the GSA... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Reports on GSA Federal... Services Administration 54-ADVISORY COMMITTEE MANAGEMENT 54.4-Reports § 105-54.401 Reports on GSA Federal...

  15. 41 CFR 105-54.401 - Reports on GSA Federal Advisory Committees.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... fiscal year report to the Congress. Instructions for preparing GSA's submission are provided by the GSA... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Reports on GSA Federal... Services Administration 54-ADVISORY COMMITTEE MANAGEMENT 54.4-Reports § 105-54.401 Reports on GSA Federal...

  16. 41 CFR 105-54.401 - Reports on GSA Federal Advisory Committees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... fiscal year report to the Congress. Instructions for preparing GSA's submission are provided by the GSA... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Reports on GSA Federal... Services Administration 54-ADVISORY COMMITTEE MANAGEMENT 54.4-Reports § 105-54.401 Reports on GSA Federal...

  17. 41 CFR 105-54.401 - Reports on GSA Federal Advisory Committees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... fiscal year report to the Congress. Instructions for preparing GSA's submission are provided by the GSA... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Reports on GSA Federal... Services Administration 54-ADVISORY COMMITTEE MANAGEMENT 54.4-Reports § 105-54.401 Reports on GSA Federal...

  18. Modular acute system for general surgery: hand over the operation, not the patient.

    PubMed

    Poole, Garth H; Glyn, Tamara; Srinivasa, Sanket; Hill, Andrew G

    2012-03-01

    Various models have been proposed to effectively provide acute surgical care in Australasia. Recently, General Surgeons Australia (GSA) has published a 12-point plan with guiding principles on this matter. This study describes a model of providing acute general surgical care in a high-volume institution, evaluates clinical outcomes and critically appraises the system against the GSA 12-point plan. The acute care system is qualitatively described with quantitative measures of workload. The outcomes of acute laparoscopic cholecystectomy were used as a proxy of system performance. The system was critically appraised against the GSA 12-point plan. Teams are on call once per week with each surgeon on call once per fortnight. The three key elements of acute management - collecting patients, post-acute ward round and operating - are treated as modules. The patient remains under the care of the admitting consultant but is often operated on by another team. From June 2009 to 2010, there were 7429 acute general surgical admissions (mean: 20.4 patients per day) with 2999 acute operations (mean: 8.4 operations per day). The other activities of the department were not compromised. In that time, 388 acute laparoscopic cholecystectomies were performed with a conversion rate of 1.3% and no major bile duct injury. The system is compatible with the GSA 12-point plan. This study describes an efficient and safe system for providing acute general surgical care in a high-volume setting with satisfactory clinical outcomes. It is compatible with the GSA 12-point plan. © 2012 The Authors. ANZ Journal of Surgery © 2012 Royal Australasian College of Surgeons.

  19. Support and Dissemination of Teacher-Authored Lesson Plans: a Digital Library for Earth System Education (DLESE) and Geological Society of America (GSA) Collaboration

    NASA Astrophysics Data System (ADS)

    Devaul, H.; Pandya, R. E.; McLelland, C. V.

    2003-12-01

    The Digital Library for Earth System Education (www.dlese.org) and the Geological Society of America (www.geosociety.org) are working together to publish and disseminate teacher-authored Earth science lesson plans. DLESE is a community-based effort involving teachers, students, and scientists working together to create a library of educational resources and services to support Earth system science education. DLESE offers free access to electronic resources including lesson plans, maps, images, data sets, visualizations, and assessment activities. A number of thematic collections have recently been accessioned, which has substantially increased library holdings. Working in concert with GSA, a non-profit organization dedicated to the advancement of the geosciences, small-scale resource creators such as classroom teachers without access to a web server can also share educational resources of their own design. Following a two-step process, lesson plans are submitted to the GSA website, reviewed and posted to the K-12 resource area: http://www.geosociety.org/educate/resources.htm. These resources are also submitted to the DLESE Community Collection using a simple cataloging tool. In this way resources are available to other teachers via the GSA website as well as via the DLESE collection. GSA provides a template for lesson plan developers which assists in providing the necessary information to help users find and understand the intent of the activity when searching in DLESE. This initial effort can serve as a prototype for important services allowing individual community members to contribute their work to DLESE with little technical overhead.

  20. Development of optimization model for sputtering process parameter based on gravitational search algorithm

    NASA Astrophysics Data System (ADS)

    Norlina, M. S.; Diyana, M. S. Nor; Mazidah, P.; Rusop, M.

    2016-07-01

    In the RF magnetron sputtering process, the desirable layer properties are largely influenced by the process parameters and conditions. If the quality of the thin film has not reached up to its intended level, the experiments have to be repeated until the desirable quality has been met. This research is proposing Gravitational Search Algorithm (GSA) as the optimization model to reduce the time and cost to be spent in the thin film fabrication. The optimization model's engine has been developed using Java. The model is developed based on GSA concept, which is inspired by the Newtonian laws of gravity and motion. In this research, the model is expected to optimize four deposition parameters which are RF power, deposition time, oxygen flow rate and substrate temperature. The results have turned out to be promising and it could be concluded that the performance of the model is satisfying in this parameter optimization problem. Future work could compare GSA with other nature based algorithms and test them with various set of data.

  1. 78 FR 22880 - Privacy Act of 1974; Notice of cancellation of System of Record Notice (SORN)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... Administration (GSA). ACTION: Withdrawal of GSA/GOV-8 Excluded Parties List System (EPLS) System of Record Notice... Services Administration (GSA), is canceling the following system of record notice: GSA/GOV-8 Excluded... or email the GSA Privacy Act Officer: telephone 202-208-1317; email [email protected]gov...

  2. 41 CFR 102-85.215 - What if another customer agency forces a GSA customer to move?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... agency forces a GSA customer to move? 102-85.215 Section 102-85.215 Public Contracts and Property... PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Continued Occupancy, Relocation and Forced Moves § 102-85.215 What if another customer agency forces a GSA customer to move? If a GSA customer agency, or...

  3. 41 CFR 102-85.215 - What if another customer agency forces a GSA customer to move?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... agency forces a GSA customer to move? 102-85.215 Section 102-85.215 Public Contracts and Property... PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Continued Occupancy, Relocation and Forced Moves § 102-85.215 What if another customer agency forces a GSA customer to move? If a GSA customer agency, or...

  4. 41 CFR 102-85.215 - What if another customer agency forces a GSA customer to move?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... agency forces a GSA customer to move? 102-85.215 Section 102-85.215 Public Contracts and Property... PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Continued Occupancy, Relocation and Forced Moves § 102-85.215 What if another customer agency forces a GSA customer to move? If a GSA customer agency, or...

  5. Biodegradation of 2,4'-dichlorobiphenyl, a congener of polychlorinated biphenyl, by Pseudomonas isolates GSa and GSb.

    PubMed

    Gayathri, D; Shobha, K J

    2015-08-01

    Bioegradation of 2,4'-dichlorobiphenyl (2,4 CB), by two isolates of Pseudomonas (GSa and GSb) was compared using GC-MS. Transformer oil polluted soil was used for the isolation of 2,4 CB degrading bacteria. GC-MS analysis of the solvent extracts obtained from Pseudomonas sp. GSa spent culture indicated the presence of Phenol 2,6-bis (1,1-dimethyl)-4-methyl (C15H24O). Further, the enzyme analysis of the cell free extracts showed the presence of 2,4'-dichlorobiphenyl dehalogenase (CBD), 2,4'-dichlorobiphenyl-NADPH-oxido-reductase (2,4 CBOR) and 2,3-dihydroxybiphenyl-NADPH-oxido-reductase (2,3 DHOR) with specific activity of 6.00, 0.4 and 0.22 pmol/min/mg of protein, suggesting that dechlorination as an important step during 2,4 CB catabolism. Further, the cell free extract of GSb showed only 2,4'-dichlorobiphenyl-NADPH-oxido-reductase (2,4 CBOR) and 2,3-dihydroxybiphenyl-NADPH-oxido-reductase (2,3 DHOR), with specific activity of 0.3 and 0.213 μmol/min/mg of protein, suggesting attack on non-chlorinated aromatic ring of 2,4 CB, releasing chlorinated intermediates which are toxic to the environment. Although, both the isolated bacteria (GSa and GSb) belong to Pseudomonas spp., they exhibited different metabolic potential.

  6. 41 CFR 102-33.35 - How can we get help in carrying out our responsibilities?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....20); or (b) Find more information on the Internet from the following Web sites: (1) http://www.gsa.gov/aircraftpolicy (GSA Aircraft Management Policy Division). (2) http://www.gsa.gov/travelpolicy (GSA...

  7. 41 CFR 102-33.35 - How can we get help in carrying out our responsibilities?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....20); or (b) Find more information on the Internet from the following Web sites: (1) http://www.gsa.gov/aircraftpolicy (GSA Aircraft Management Policy Division). (2) http://www.gsa.gov/travelpolicy (GSA...

  8. 41 CFR 102-33.35 - How can we get help in carrying out our responsibilities?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ....20); or (b) Find more information on the Internet from the following Web sites: (1) http://www.gsa.gov/aircraftpolicy (GSA Aircraft Management Policy Division). (2) http://www.gsa.gov/travelpolicy (GSA...

  9. 41 CFR 102-33.35 - How can we get help in carrying out our responsibilities?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....20); or (b) Find more information on the Internet from the following Web sites: (1) http://www.gsa.gov/aircraftpolicy (GSA Aircraft Management Policy Division). (2) http://www.gsa.gov/travelpolicy (GSA...

  10. Reducing risk for illicit drug use and prescription drug misuse: High school gay-straight alliances and lesbian, gay, bisexual, and transgender youth.

    PubMed

    Heck, Nicholas C; Livingston, Nicholas A; Flentje, Annesa; Oost, Kathryn; Stewart, Brandon T; Cochran, Bryan N

    2014-04-01

    Previous research suggests that lesbian, gay, bisexual, and transgender (LGBT) youth are at elevated risk for using illicit drugs and misusing prescription drugs relative to heterosexual youth. Previous research also indicates that LGBT youth who attend high schools with a gay-straight alliance (GSA) report having fewer alcohol problems and lower levels of cigarette smoking. The present study investigates whether the absence of a GSA is associated with risk for illicit drug use and prescription drug misuse in a sample of 475 LGBT high school students (M age=16.79) who completed an online survey. After controlling for demographic variables and risk factors associated with illicit drug use, the results of 12 logistic regression analyses revealed that LGBT youth attending a high school without a GSA evidenced increased risk for using cocaine (adjusted odds ratio [adjOR]=3.11; 95% confidence interval [95% CI]=1.23-7.86), hallucinogens (adjOR=2.59; 95% CI=1.18-5.70), and marijuana (adjOR=2.22; 95% CI=1.37-3.59) relative to peers attending a high school with a GSA. Youth without a GSA also evidenced increased risk for the misuse of ADHD medication (adjOR=2.00; 95% CI=1.02-3.92) and prescription pain medication (adjOR=2.00; 95% CI=1.10-3.65). These findings extend the research base related to GSAs and further demonstrate the importance of providing LGBT youth with opportunities for socialization and support within the school setting. Important limitations of the present study are reviewed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Genome-Wide Prediction of the Performance of Three-Way Hybrids in Barley.

    PubMed

    Li, Zuo; Philipp, Norman; Spiller, Monika; Stiewe, Gunther; Reif, Jochen C; Zhao, Yusheng

    2017-03-01

    Predicting the grain yield performance of three-way hybrids is challenging. Three-way crosses are relevant for hybrid breeding in barley ( L.) and maize ( L.) adapted to East Africa. The main goal of our study was to implement and evaluate genome-wide prediction approaches of the performance of three-way hybrids using data of single-cross hybrids for a scenario in which parental lines of the three-way hybrids originate from three genetically distinct subpopulations. We extended the ridge regression best linear unbiased prediction (RRBLUP) and devised a genomic selection model allowing for subpopulation-specific marker effects (GSA-RRBLUP: general and subpopulation-specific additive RRBLUP). Using an empirical barley data set, we showed that applying GSA-RRBLUP tripled the prediction ability of three-way hybrids from 0.095 to 0.308 compared with RRBLUP, modeling one additive effect for all three subpopulations. The experimental findings were further substantiated with computer simulations. Our results emphasize the potential of GSA-RRBLUP to improve genome-wide hybrid prediction of three-way hybrids for scenarios of genetically diverse parental populations. Because of the advantages of the GSA-RRBLUP model in dealing with hybrids from different parental populations, it may also be a promising approach to boost the prediction ability for hybrid breeding programs based on genetically diverse heterotic groups. Copyright © 2017 Crop Science Society of America.

  12. GSA's Green Proving Ground: Identifying, Testing and Evaluating Innovative Technologies (Presentation)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kandt, A.; Lowell, M.

    2012-05-01

    GSA's Green Proving Ground (GPG) program utilizes GSA's real estate portfolio to test and evaluate innovative and underutilized sustainable building technologies and practices. Findings are used to support the development of GSA performance specifications and inform decision making within GSA, other federal agencies, and the real estate industry. The program aims to drive innovation in environmental performance in federal buildings and help lead market transformation through deployment of new technologies.

  13. Integration of the work-related online aftercare intervention 'GSA-online plus' (healthy and without stress at the workplace) into clinical practice: study protocol for an implementation study.

    PubMed

    Zwerenz, Rüdiger; Böhme, Katja; Wirth, Astrid; Labitzke, Nicole; Pachtchenko, Sergei; Beutel, Manfred E

    2018-05-02

    In a previous RCT we established the efficacy of the psychodynamic online aftercare programme 'GSA-Online' ('Health Training Stress Management at the Workplace') for rehabilitants with work-related stress facing return to work after long-term sickness absence. The purpose of this trial is to implement it into routine care. The study is performed in rehabilitation clinics with patients of different medical indications (psychosomatic, orthopedic and cardiological diseases). Rehabilitants get access to the study platform during inpatient medical rehabilitation. 'GSA-Online plus' integrates exploratory and motivational videos on the web application to familiarize potential participants and motivate them to follow through with it. In the 12-week writing intervention, patients write weekly online diary entries, answered by anonymous online therapists within 24 h. Primary outcome measures are the recommendation rate of 'GSA-Online plus' and participation rates of the rehabilitants. As secondary outcomes, psychological symptoms, overall satisfaction, helpfulness of the therapeutic feedback and utilization of 'GSA-Online plus' will be analysed exploratory along with the course of weekly ratings of well-being and work ability. Meanwhile many clinical trials and meta-analysis prove that internet-based interventions are effective. This study will add insights on the dissemination and implementation of efficacious, evidence-based online treatments into medical practice. We expect a successful implementation of 'GSA-Online plus' in the clinical routine of the rehabilitation clinics. The focus of evaluation is on acceptance of the programme, both by the physicians in charge and the patients. In the future 'GSA-Online plus' could be implemented as a routine aftercare programme for rehabilitation inpatients with occupational stress. The trial was retrospectively registered on 6th January 2017 at ClinicalTrials.gov (Trial Registration number: ClinicalTrials Gov ID NCT03019718 ).

  14. Effects of gaseous sulphuric acid on diesel exhaust nanoparticle formation and characteristics.

    PubMed

    Rönkkö, Topi; Lähde, Tero; Heikkilä, Juha; Pirjola, Liisa; Bauschke, Ulrike; Arnold, Frank; Schlager, Hans; Rothe, Dieter; Yli-Ojanperä, Jaakko; Keskinen, Jorma

    2013-10-15

    Diesel exhaust gaseous sulphuric acid (GSA) concentrations and particle size distributions, concentrations, and volatility were studied at four driving conditions with a heavy duty diesel engine equipped with oxidative exhaust after-treatment. Low sulfur fuel and lubricant oil were used in the study. The concentration of the exhaust GSA was observed to vary depending on the engine driving history and load. The GSA affected the volatile particle fraction at high engine loads; higher GSA mole fraction was followed by an increase in volatile nucleation particle concentration and size as well as increase of size of particles possessing nonvolatile core. The GSA did not affect the number of nonvolatile particles. At low and medium loads, the exhaust GSA concentration was low and any GSA driven changes in particle population were not observed. Results show that during the exhaust cooling and dilution processes, besides critical in volatile nucleation particle formation, GSA can change the characteristics of all nucleation mode particles. Results show the dual nature of the nucleation mode particles so that the nucleation mode can include simultaneously volatile and nonvolatile particles, and fulfill the previous results for the nucleation mode formation, especially related to the role of GSA in formation processes.

  15. 77 FR 9659 - General Services Administration Acquisition Regulation; Information Collection; GSA Mentor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-17

    ... Services Administration Acquisition Regulation; Information Collection; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration...- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations.gov : http...

  16. 41 CFR 101-26.206 - GSA assistance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAM 26.2-Federal Requisitioning System § 101-26.206 GSA assistance. Agency field activities should... addresses of GSA regional offices are listed in each of the volumes of the GSA Supply Catalog. Agency....206 Section 101-26.206 Public Contracts and Property Management Federal Property Management...

  17. 41 CFR 101-26.206 - GSA assistance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAM 26.2-Federal Requisitioning System § 101-26.206 GSA assistance. Agency field activities should... addresses of GSA regional offices are listed in each of the volumes of the GSA Supply Catalog. Agency....206 Section 101-26.206 Public Contracts and Property Management Federal Property Management...

  18. 41 CFR 101-26.206 - GSA assistance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAM 26.2-Federal Requisitioning System § 101-26.206 GSA assistance. Agency field activities should... addresses of GSA regional offices are listed in each of the volumes of the GSA Supply Catalog. Agency....206 Section 101-26.206 Public Contracts and Property Management Federal Property Management...

  19. 41 CFR 101-26.206 - GSA assistance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAM 26.2-Federal Requisitioning System § 101-26.206 GSA assistance. Agency field activities should... addresses of GSA regional offices are listed in each of the volumes of the GSA Supply Catalog. Agency....206 Section 101-26.206 Public Contracts and Property Management Federal Property Management...

  20. 41 CFR 101-26.206 - GSA assistance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAM 26.2-Federal Requisitioning System § 101-26.206 GSA assistance. Agency field activities should... addresses of GSA regional offices are listed in each of the volumes of the GSA Supply Catalog. Agency....206 Section 101-26.206 Public Contracts and Property Management Federal Property Management...

  1. Parameter screening: the use of a dummy parameter to identify non-influential parameters in a global sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Khorashadi Zadeh, Farkhondeh; Nossent, Jiri; van Griensven, Ann; Bauwens, Willy

    2017-04-01

    Parameter estimation is a major concern in hydrological modeling, which may limit the use of complex simulators with a large number of parameters. To support the selection of parameters to include in or exclude from the calibration process, Global Sensitivity Analysis (GSA) is widely applied in modeling practices. Based on the results of GSA, the influential and the non-influential parameters are identified (i.e. parameters screening). Nevertheless, the choice of the screening threshold below which parameters are considered non-influential is a critical issue, which has recently received more attention in GSA literature. In theory, the sensitivity index of a non-influential parameter has a value of zero. However, since numerical approximations, rather than analytical solutions, are utilized in GSA methods to calculate the sensitivity indices, small but non-zero indices may be obtained for the indices of non-influential parameters. In order to assess the threshold that identifies non-influential parameters in GSA methods, we propose to calculate the sensitivity index of a "dummy parameter". This dummy parameter has no influence on the model output, but will have a non-zero sensitivity index, representing the error due to the numerical approximation. Hence, the parameters whose indices are above the sensitivity index of the dummy parameter can be classified as influential, whereas the parameters whose indices are below this index are within the range of the numerical error and should be considered as non-influential. To demonstrated the effectiveness of the proposed "dummy parameter approach", 26 parameters of a Soil and Water Assessment Tool (SWAT) model are selected to be analyzed and screened, using the variance-based Sobol' and moment-independent PAWN methods. The sensitivity index of the dummy parameter is calculated from sampled data, without changing the model equations. Moreover, the calculation does not even require additional model evaluations for the Sobol' method. A formal statistical test validates these parameter screening results. Based on the dummy parameter screening, 11 model parameters are identified as influential. Therefore, it can be denoted that the "dummy parameter approach" can facilitate the parameter screening process and provide guidance for GSA users to define a screening-threshold, with only limited additional resources. Key words: Parameter screening, Global sensitivity analysis, Dummy parameter, Variance-based method, Moment-independent method

  2. 77 FR 31016 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration... Collection 3090- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations...

  3. 75 FR 13131 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Advantage...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... Services Administration Acquisition Regulation; Submission for OMB Review; GSA Advantage![reg] and... requirement regarding GSA Advantage![reg] and Electronic Commerce-FACNET. A request for public comments was..., Washington, DC 20405. Please cite OMB Control No. 3090-00XX, GSA Advantage![reg] and Electronic Commerce...

  4. A comprehensive approach to identify dominant controls of the behavior of a land surface-hydrology model across various hydroclimatic conditions

    NASA Astrophysics Data System (ADS)

    Haghnegahdar, Amin; Elshamy, Mohamed; Yassin, Fuad; Razavi, Saman; Wheater, Howard; Pietroniro, Al

    2017-04-01

    Complex physically-based environmental models are being increasingly used as the primary tool for watershed planning and management due to advances in computation power and data acquisition. Model sensitivity analysis plays a crucial role in understanding the behavior of these complex models and improving their performance. Due to the non-linearity and interactions within these complex models, Global sensitivity analysis (GSA) techniques should be adopted to provide a comprehensive understanding of model behavior and identify its dominant controls. In this study we adopt a multi-basin multi-criteria GSA approach to systematically assess the behavior of the Modélisation Environmentale-Surface et Hydrologie (MESH) across various hydroclimatic conditions in Canada including areas in the Great Lakes Basin, Mackenzie River Basin, and South Saskatchewan River Basin. MESH is a semi-distributed physically-based coupled land surface-hydrology modelling system developed by Environment and Climate Change Canada (ECCC) for various water resources management purposes in Canada. We use a novel method, called Variogram Analysis of Response Surfaces (VARS), to perform sensitivity analysis. VARS is a variogram-based GSA technique that can efficiently provide a spectrum of sensitivity information across a range of scales within the parameter space. We use multiple metrics to identify dominant controls of model response (e.g. streamflow) to model parameters under various conditions such as high flows, low flows, and flow volume. We also investigate the influence of initial conditions on model behavior as part of this study. Our preliminary results suggest that this type of GSA can significantly help with estimating model parameters, decreasing calibration computational burden, and reducing prediction uncertainty.

  5. 48 CFR 519.7004 - Incentives for prime contractors.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7004 Incentives for prime...) Costs incurred by a mentor to provide developmental assistance, as described in section 519.7012 to... under a GSA contract. If GSA is the mentor's responsible audit agency under FAR 42.703-1, GSA will...

  6. 48 CFR 519.7009 - Application process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7009 Application process. (a) Prime contractors interested in becoming a mentor firm must apply in writing by submitting the GSA Form 3695 to the GSA Mentor-Protégé Program Manager, at GSA Office of Small Business Utilization (E...

  7. 77 FR 38064 - Public Buildings Service; Information Collection; GSA Form 3453, Application/Permit for Use of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... Buildings Service; Information Collection; GSA Form 3453, Application/Permit for Use of Space in Public Buildings and Grounds AGENCY: Public Buildings Service, GSA. ACTION: Notice of request for comments... regarding GSA Form 3453, Application/Permit for Use of Space in Public Buildings and Grounds. Public...

  8. Gay-Straight Alliances, Social Justice Involvement, and School Victimization of Lesbian, Gay, Bisexual, and Queer Youth: Implications for School Well-Being and Plans to Vote

    PubMed Central

    Toomey, Russell B.; Russell, Stephen T.

    2015-01-01

    Few studies have investigated school-based, positive development for lesbian, gay, bisexual, and queer (LGBQ) youth, despite knowledge of their heightened negative school experiences compared to heterosexual youth (e.g., school victimization). This study examines associations among participation in Gay-Straight Alliance (GSA)–related social justice activities, GSA presence, and GSA membership with victimization based on sexual orientation and school-based well-being (i.e., school safety, school belongingness, grade point average [GPA]) and future plans to vote. Using data from the Preventing School Harassment Study, a survey of 230 LGBQ students in 7th through 12th grades, the study finds that participation in GSA-related social justice activities and the presence of a GSA are positively associated with school belongingness and GPA. GSA membership is also positively associated with school belongingness. However, moderation analyses suggest that the positive benefits of GSA-related social justice involvement and the presence of a GSA dissipate at high levels of school victimization. Implications for schools are discussed. PMID:26224893

  9. A multimethod Global Sensitivity Analysis to aid the calibration of geomechanical models via time-lapse seismic data

    NASA Astrophysics Data System (ADS)

    Price, D. C.; Angus, D. A.; Garcia, A.; Fisher, Q. J.; Parsons, S.; Kato, J.

    2018-03-01

    Time-lapse seismic attributes are used extensively in the history matching of production simulator models. However, although proven to contain information regarding production induced stress change, it is typically only loosely (i.e. qualitatively) used to calibrate geomechanical models. In this study we conduct a multimethod Global Sensitivity Analysis (GSA) to assess the feasibility and aid the quantitative calibration of geomechanical models via near-offset time-lapse seismic data. Specifically, the calibration of mechanical properties of the overburden. Via the GSA, we analyse the near-offset overburden seismic traveltimes from over 4000 perturbations of a Finite Element (FE) geomechanical model of a typical High Pressure High Temperature (HPHT) reservoir in the North Sea. We find that, out of an initially large set of material properties, the near-offset overburden traveltimes are primarily affected by Young's modulus and the effective stress (i.e. Biot) coefficient. The unexpected significance of the Biot coefficient highlights the importance of modelling fluid flow and pore pressure outside of the reservoir. The FE model is complex and highly nonlinear. Multiple combinations of model parameters can yield equally possible model realizations. Consequently, numerical calibration via a large number of random model perturbations is unfeasible. However, the significant differences in traveltime results suggest that more sophisticated calibration methods could potentially be feasible for finding numerous suitable solutions. The results of the time-varying GSA demonstrate how acquiring multiple vintages of time-lapse seismic data can be advantageous. However, they also suggest that significant overburden near-offset seismic time-shifts, useful for model calibration, may take up to 3 yrs after the start of production to manifest. Due to the nonlinearity of the model behaviour, similar uncertainty in the reservoir mechanical properties appears to influence overburden traveltime to a much greater extent. Therefore, reservoir properties must be known to a suitable degree of accuracy before the calibration of the overburden can be considered.

  10. 41 CFR 101-1.4902-2053 - GSA Form 2053, Agency Consolidated Requirements for GSA Regulations and Other External Issuances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-2053 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.49-Illustrations of Forms § 101-1.4902-2053 GSA... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true GSA Form 2053, Agency...

  11. 77 FR 31017 - Office of Facilities Management and Program Services; Information Collection; Background...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... a Basic National Agency Check Criminal History, GSA Form 176; and 2. Two sets of fingerprints on FBI Fingerprint Cards, for FD-258. This is not a request to collect new information, this is a request to change...

  12. Can we calibrate simultaneously groundwater recharge and aquifer hydrodynamic parameters ?

    NASA Astrophysics Data System (ADS)

    Hassane Maina, Fadji; Ackerer, Philippe; Bildstein, Olivier

    2017-04-01

    By groundwater model calibration, we consider here fitting the measured piezometric heads by estimating the hydrodynamic parameters (storage term and hydraulic conductivity) and the recharge. It is traditionally recommended to avoid simultaneous calibration of groundwater recharge and flow parameters because of correlation between recharge and the flow parameters. From a physical point of view, little recharge associated with low hydraulic conductivity can provide very similar piezometric changes than higher recharge and higher hydraulic conductivity. If this correlation is true under steady state conditions, we assume that this correlation is much weaker under transient conditions because recharge varies in time and the parameters do not. Moreover, the recharge is negligible during summer time for many climatic conditions due to reduced precipitation, increased evaporation and transpiration by vegetation cover. We analyze our hypothesis through global sensitivity analysis (GSA) in conjunction with the polynomial chaos expansion (PCE) methodology. We perform GSA by calculating the Sobol indices, which provide a variance-based 'measure' of the effects of uncertain parameters (storage and hydraulic conductivity) and recharge on the piezometric heads computed by the flow model. The choice of PCE has the following two benefits: (i) it provides the global sensitivity indices in a straightforward manner, and (ii) PCE can serve as a surrogate model for the calibration of parameters. The coefficients of the PCE are computed by probabilistic collocation. We perform the GSA on simplified real conditions coming from an already built groundwater model dedicated to a subdomain of the Upper-Rhine aquifer (geometry, boundary conditions, climatic data). GSA shows that the simultaneous calibration of recharge and flow parameters is possible if the calibration is performed over at least one year. It provides also the valuable information of the sensitivity versus time, depending on the aquifer inertia and climatic conditions. The groundwater levels variations during recharge (increase) are sensitive to the storage coefficient whereas the groundwater levels variations after recharge (decrease) are sensitive to the hydraulic conductivity. The performed model calibration on synthetic data sets shows that the parameters and recharge are estimated quite accurately.

  13. Modified GMDH-NN algorithm and its application for global sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Song, Shufang; Wang, Lu

    2017-11-01

    Global sensitivity analysis (GSA) is a very useful tool to evaluate the influence of input variables in the whole distribution range. Sobol' method is the most commonly used among variance-based methods, which are efficient and popular GSA techniques. High dimensional model representation (HDMR) is a popular way to compute Sobol' indices, however, its drawbacks cannot be ignored. We show that modified GMDH-NN algorithm can calculate coefficients of metamodel efficiently, so this paper aims at combining it with HDMR and proposes GMDH-HDMR method. The new method shows higher precision and faster convergent rate. Several numerical and engineering examples are used to confirm its advantages.

  14. 41 CFR 105-64.111 - What is GSA's policy on directives that may conflict with this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.111 What is GSA's policy on directives that may conflict with this part? These rules take... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is GSA's policy on...

  15. 41 CFR 105-64.111 - What is GSA's policy on directives that may conflict with this part?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.111 What is GSA's policy on directives that may conflict with this part? These rules take... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What is GSA's policy on...

  16. 41 CFR 105-64.106 - What is GSA's policy on information accuracy in a system of records?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.106 What is GSA's policy on information accuracy in a system of records? System managers... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What is GSA's policy on...

  17. 41 CFR 105-64.102 - What is GSA's policy on disclosure of information in a system of records?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.102 What is GSA's policy on disclosure of information in a system of records? No... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What is GSA's policy on...

  18. 41 CFR 105-64.102 - What is GSA's policy on disclosure of information in a system of records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.102 What is GSA's policy on disclosure of information in a system of records? No... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is GSA's policy on...

  19. 41 CFR 105-64.106 - What is GSA's policy on information accuracy in a system of records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.106 What is GSA's policy on information accuracy in a system of records? System managers... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is GSA's policy on...

  20. 48 CFR 552.219-75 - GSA Mentor-Protégé Program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false GSA Mentor-ProtégÃ....219-75 GSA Mentor-Protégé Program. As prescribed in 519.7017(a), insert the following clause: GSA Mentor-ProtéGé Program (SEP 2009) (a) Prime contractors, including small businesses, are encouraged to...

  1. 77 FR 5252 - Federal Travel Regulation; GSA E-Gov Travel Service (ETS) Transition to E-Gov Travel Service 2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... Travel Regulation; GSA E-Gov Travel Service (ETS) Transition to E-Gov Travel Service 2 (ETS2) AGENCY... (QMC), at [email protected]gov or (703) 605-2151. SUPPLEMENTARY INFORMATION: The Federal Travel...-GOV TRAVEL SERVICE GSA Bulletin ETS 12-01 TO: Heads of Federal Agencies SUBJECT: GSA E-Gov Travel...

  2. High School Gay-Straight Alliances (GSAs) and Young Adult Well-Being: An Examination of GSA Presence, Participation, and Perceived Effectiveness

    PubMed Central

    Toomey, Russell B.; Ryan, Caitlin; Diaz, Rafael M.; Russell, Stephen T.

    2011-01-01

    Gay-Straight Alliances (GSAs) are student-led, school-based clubs that aim to provide a safe environment in the school context for lesbian, gay, bisexual, and transgender (LGBT) students, as well as their straight allies. The present study examines the potential for GSAs to support positive youth development and to reduce associations among LGBT-specific school victimization and negative young adult well-being. The sample includes 245 LGBT young adults, ages 21–25, who retrospectively reported on the presence of a GSA in their high school, their participation in their school’s GSA, and their perceptions of whether or not their GSA was effective in improving school safety. Findings revealed that the presence of a GSA, participation in a GSA, and perceived GSA effectiveness in promoting school safety were differentially associated with young adult well-being and in some cases, buffered the negative association between LGBT-specific school victimization and well-being. Implications for future research and schools are discussed. PMID:22102782

  3. 48 CFR 8.703 - Procurement list.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the General Services Administration (GSA) Supply Catalog and GSA's Customer Service Center Catalogs... Defense Logistics Agency (DLA) and the Department of Veterans Affairs (VA). GSA, DLA, and VA are central...

  4. The Impact of Parametric Uncertainties on Biogeochemistry in the E3SM Land Model

    NASA Astrophysics Data System (ADS)

    Ricciuto, Daniel; Sargsyan, Khachik; Thornton, Peter

    2018-02-01

    We conduct a global sensitivity analysis (GSA) of the Energy Exascale Earth System Model (E3SM), land model (ELM) to calculate the sensitivity of five key carbon cycle outputs to 68 model parameters. This GSA is conducted by first constructing a Polynomial Chaos (PC) surrogate via new Weighted Iterative Bayesian Compressive Sensing (WIBCS) algorithm for adaptive basis growth leading to a sparse, high-dimensional PC surrogate with 3,000 model evaluations. The PC surrogate allows efficient extraction of GSA information leading to further dimensionality reduction. The GSA is performed at 96 FLUXNET sites covering multiple plant functional types (PFTs) and climate conditions. About 20 of the model parameters are identified as sensitive with the rest being relatively insensitive across all outputs and PFTs. These sensitivities are dependent on PFT, and are relatively consistent among sites within the same PFT. The five model outputs have a majority of their highly sensitive parameters in common. A common subset of sensitive parameters is also shared among PFTs, but some parameters are specific to certain types (e.g., deciduous phenology). The relative importance of these parameters shifts significantly among PFTs and with climatic variables such as mean annual temperature.

  5. 48 CFR 8.703 - Procurement list.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... identified in the General Services Administration (GSA) Supply Catalog and GSA's Customer Service Center... the Defense Logistics Agency (DLA) and the Department of Veterans Affairs (VA). GSA, DLA, and VA are...

  6. 48 CFR 8.703 - Procurement list.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... identified in the General Services Administration (GSA) Supply Catalog and GSA's Customer Service Center... the Defense Logistics Agency (DLA) and the Department of Veterans Affairs (VA). GSA, DLA, and VA are...

  7. Optimized hyperspectral band selection using hybrid genetic algorithm and gravitational search algorithm

    NASA Astrophysics Data System (ADS)

    Zhang, Aizhu; Sun, Genyun; Wang, Zhenjie

    2015-12-01

    The serious information redundancy in hyperspectral images (HIs) cannot contribute to the data analysis accuracy, instead it require expensive computational resources. Consequently, to identify the most useful and valuable information from the HIs, thereby improve the accuracy of data analysis, this paper proposed a novel hyperspectral band selection method using the hybrid genetic algorithm and gravitational search algorithm (GA-GSA). In the proposed method, the GA-GSA is mapped to the binary space at first. Then, the accuracy of the support vector machine (SVM) classifier and the number of selected spectral bands are utilized to measure the discriminative capability of the band subset. Finally, the band subset with the smallest number of spectral bands as well as covers the most useful and valuable information is obtained. To verify the effectiveness of the proposed method, studies conducted on an AVIRIS image against two recently proposed state-of-the-art GSA variants are presented. The experimental results revealed the superiority of the proposed method and indicated that the method can indeed considerably reduce data storage costs and efficiently identify the band subset with stable and high classification precision.

  8. Structure and weights optimisation of a modified Elman network emotion classifier using hybrid computational intelligence algorithms: a comparative study

    NASA Astrophysics Data System (ADS)

    Sheikhan, Mansour; Abbasnezhad Arabi, Mahdi; Gharavian, Davood

    2015-10-01

    Artificial neural networks are efficient models in pattern recognition applications, but their performance is dependent on employing suitable structure and connection weights. This study used a hybrid method for obtaining the optimal weight set and architecture of a recurrent neural emotion classifier based on gravitational search algorithm (GSA) and its binary version (BGSA), respectively. By considering the features of speech signal that were related to prosody, voice quality, and spectrum, a rich feature set was constructed. To select more efficient features, a fast feature selection method was employed. The performance of the proposed hybrid GSA-BGSA method was compared with similar hybrid methods based on particle swarm optimisation (PSO) algorithm and its binary version, PSO and discrete firefly algorithm, and hybrid of error back-propagation and genetic algorithm that were used for optimisation. Experimental tests on Berlin emotional database demonstrated the superior performance of the proposed method using a lighter network structure.

  9. 41 CFR 105-53.140 - Office of Operations and Industry Relations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., is responsible for formulating GSA-wide policy that relates to regional operations, supervising GSA's Regional Administrators, and planning and coordinating GSA business and industry relations and customer...

  10. 41 CFR 105-64.103 - What is GSA's policy on collecting and using information in a system of records?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.103 What is GSA's policy on collecting and using information in a system of records... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What is GSA's policy on...

  11. 41 CFR 105-64.103 - What is GSA's policy on collecting and using information in a system of records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.103 What is GSA's policy on collecting and using information in a system of records... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is GSA's policy on...

  12. 48 CFR 339.7001 - Request for approval to make an award to other than a GSA BPA holder.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... make an award to other than a GSA BPA holder. 339.7001 Section 339.7001 Federal Acquisition Regulations... Services 339.7001 Request for approval to make an award to other than a GSA BPA holder. The Contracting... micro-purchase threshold, that obtaining the required services from a source other than a GSA BPA holder...

  13. 48 CFR 339.7001 - Request for approval to make an award to other than a GSA BPA holder.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... make an award to other than a GSA BPA holder. 339.7001 Section 339.7001 Federal Acquisition Regulations... Services 339.7001 Request for approval to make an award to other than a GSA BPA holder. The Contracting... micro-purchase threshold, that obtaining the required services from a source other than a GSA BPA holder...

  14. 48 CFR 339.7001 - Request for approval to make an award to other than a GSA BPA holder.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... make an award to other than a GSA BPA holder. 339.7001 Section 339.7001 Federal Acquisition Regulations... Services 339.7001 Request for approval to make an award to other than a GSA BPA holder. The Contracting... micro-purchase threshold, that obtaining the required services from a source other than a GSA BPA holder...

  15. 48 CFR 339.7001 - Request for approval to make an award to other than a GSA BPA holder.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... make an award to other than a GSA BPA holder. 339.7001 Section 339.7001 Federal Acquisition Regulations... Services 339.7001 Request for approval to make an award to other than a GSA BPA holder. The Contracting... micro-purchase threshold, that obtaining the required services from a source other than a GSA BPA holder...

  16. 48 CFR 339.7001 - Request for approval to make an award to other than a GSA BPA holder.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... make an award to other than a GSA BPA holder. 339.7001 Section 339.7001 Federal Acquisition Regulations... Services 339.7001 Request for approval to make an award to other than a GSA BPA holder. The Contracting... micro-purchase threshold, that obtaining the required services from a source other than a GSA BPA holder...

  17. 41 CFR 102-2.115 - What kinds of non-regulatory material does GSA publish outside of the FMR?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What kinds of non-regulatory material does GSA publish outside of the FMR? 102-2.115 Section 102-2.115 Public Contracts and....115 What kinds of non-regulatory material does GSA publish outside of the FMR? As GSA converts the...

  18. 45 CFR 12a.5 - Real property reported excess to GSA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Real property reported excess to GSA. 12a.5 Section 12a.5 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION USE OF FEDERAL REAL PROPERTY TO ASSIST THE HOMELESS § 12a.5 Real property reported excess to GSA. (a) Each landholding agency must submit a report to GSA of...

  19. 41 CFR 102-117.35 - What are the advantages and disadvantages of using GSA's tender of service?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and disadvantages of using GSA's tender of service? 102-117.35 Section 102-117.35 Public Contracts and...-117.35 What are the advantages and disadvantages of using GSA's tender of service? (a) It is an... damage claims. (b) It is a disadvantage to use GSA's tender of service when: (1) You want an agreement...

  20. Gravity response mechanisms of lateral organs and the control of plant architecture in Arabidopsis

    NASA Astrophysics Data System (ADS)

    Mullen, J.; Hangarter, R.

    Most research on gravity responses in plants has focused on primary roots and shoots, which typically grow in a vertical orientation. However, the patterns of lateral organ formation and their growth orientation, which typically are not vertical, govern plant architecture. For example, in Arabidopsis, when lateral roots emerge from the primary root, they grow at a nearly horizontal orientation. As they elongate, the roots slowly curve until they eventually reach a vertical orientation. The regulation of this lateral root orientation is an important component affecting the overall root system architecture. We have found that this change in orientation is not simply due to the onset of gravitropic competence, as non-vertical lateral roots are capable of both positive and negative gravitropism. Thus, the horizontal growth of the new lateral roots is determined by what is called the gravitropic set-point angle (GSA). In Arabidopsis shoots, rosette leaves and inflorescence branches also display GSA-dependent developmental changes in their orientation. The developmental control of the GSA of lateral organs in Arabidopsis provides us with a useful system for investigating the components involved in regulating directionality of tropistic responses. We have identified several Arabidopsis mutants that have either altered lateral root orientations, altered orientation of lateral organs in the shoot, or both, but maintain normal primary organ orientation. The mgsa ({m}odified {g}ravitropic {s}et-point {a}ngle) mutants with both altered lateral root and shoot orientation show that there are common components in the regulation of growth orientation in the different organs. Rosette leaves and lateral roots also have in common a regulation of positioning by red light. Further molecular and physiological analyses of the GSA mutants will provide insight into the basis of GSA regulation and, thus, a better understanding of how gravity controls plant architecture. [This work was supported by the National Aeronautics and Space Administration through grant no. NCC 2-1200.

  1. 41 CFR 102-34.220 - What does GSA do if it learns of unofficial use of a Government motor vehicle?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What does GSA do if it learns of unofficial use of a Government motor vehicle? 102-34.220 Section 102-34.220 Public Contracts....220 What does GSA do if it learns of unofficial use of a Government motor vehicle? GSA reports the...

  2. 41 CFR 102-34.220 - What does GSA do if it learns of unofficial use of a Government motor vehicle?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What does GSA do if it learns of unofficial use of a Government motor vehicle? 102-34.220 Section 102-34.220 Public Contracts....220 What does GSA do if it learns of unofficial use of a Government motor vehicle? GSA reports the...

  3. Application of the gravity search algorithm to multi-reservoir operation optimization

    NASA Astrophysics Data System (ADS)

    Bozorg-Haddad, Omid; Janbaz, Mahdieh; Loáiciga, Hugo A.

    2016-12-01

    Complexities in river discharge, variable rainfall regime, and drought severity merit the use of advanced optimization tools in multi-reservoir operation. The gravity search algorithm (GSA) is an evolutionary optimization algorithm based on the law of gravity and mass interactions. This paper explores the GSA's efficacy for solving benchmark functions, single reservoir, and four-reservoir operation optimization problems. The GSA's solutions are compared with those of the well-known genetic algorithm (GA) in three optimization problems. The results show that the GSA's results are closer to the optimal solutions than the GA's results in minimizing the benchmark functions. The average values of the objective function equal 1.218 and 1.746 with the GSA and GA, respectively, in solving the single-reservoir hydropower operation problem. The global solution equals 1.213 for this same problem. The GSA converged to 99.97% of the global solution in its average-performing history, while the GA converged to 97% of the global solution of the four-reservoir problem. Requiring fewer parameters for algorithmic implementation and reaching the optimal solution in fewer number of functional evaluations are additional advantages of the GSA over the GA. The results of the three optimization problems demonstrate a superior performance of the GSA for optimizing general mathematical problems and the operation of reservoir systems.

  4. Plug-Load Control and Behavioral Change Research in GSA Office Buildings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Metzger, I.; Cutler, D.; Sheppy, M.

    2012-10-01

    The U.S. General Services Administration (GSA) owns and leases over 354 million square feet (ft2) of space in over 9,600 buildings [1]. GSA is a leader among federal agencies in aggressively pursuing energy efficiency (EE) opportunities for its facilities and installing renewable energy (RE) systems to provide heating, cooling, and power to these facilities. According to several energy assessments of GSA's buildings conducted by the National Renewable Energy Laboratory (NREL), plug-loads account for approximately 21% of the total electricity consumed within a standard GSA Region 3 office building. This study aims to provide insight on how to effectively manage plug-loadmore » energy consumption and attain higher energy and cost savings for plug-loads. As GSA improves the efficiency of its building stock, plug-loads will become an even greater portion of its energy footprint.« less

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Freitez, Juan A.; Sanchez, Morella; Ruette, Fernando

    Application of simulated annealing (SA) and simplified GSA (SGSA) techniques for parameter optimization of parametric quantum chemistry method (CATIVIC) was performed. A set of organic molecules were selected for test these techniques. Comparison of the algorithms was carried out for error function minimization with respect to experimental values. Results show that SGSA is more efficient than SA with respect to computer time. Accuracy is similar in both methods; however, there are important differences in the final set of parameters.

  6. Gay-Straight Alliances are Associated with Lower Levels of School-Based Victimization of LGBTQ+ Youth: A Systematic Review and Meta-analysis.

    PubMed

    Marx, Robert A; Kettrey, Heather Hensman

    2016-07-01

    Gay-straight alliances (GSAs) are school-based organizations for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) youth and their allies that often attempt to improve school climate for sexual and gender minority youth. This meta-analysis evaluates the association between school GSA presence and youth's self-reports of school-based victimization by quantitatively synthesizing 15 primary studies with 62,923 participants. Findings indicate GSA presence is associated with significantly lower levels of youth's self-reports of homophobic victimization, fear for safety, and hearing homophobic remarks, and these results are robust, controlling for a variety of study-level factors. The findings of this meta-analysis provide evidence to support GSAs as a means of protecting LGTBQ+ youth from school-based victimization.

  7. The Impact of Parametric Uncertainties on Biogeochemistry in the E3SM Land Model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ricciuto, Daniel; Sargsyan, Khachik; Thornton, Peter

    We conduct a global sensitivity analysis (GSA) of the Energy Exascale Earth System Model (E3SM), land model (ELM) to calculate the sensitivity of five key carbon cycle outputs to 68 model parameters. This GSA is conducted by first constructing a Polynomial Chaos (PC) surrogate via new Weighted Iterative Bayesian Compressive Sensing (WIBCS) algorithm for adaptive basis growth leading to a sparse, high-dimensional PC surrogate with 3,000 model evaluations. The PC surrogate allows efficient extraction of GSA information leading to further dimensionality reduction. The GSA is performed at 96 FLUXNET sites covering multiple plant functional types (PFTs) and climate conditions. Aboutmore » 20 of the model parameters are identified as sensitive with the rest being relatively insensitive across all outputs and PFTs. These sensitivities are dependent on PFT, and are relatively consistent among sites within the same PFT. The five model outputs have a majority of their highly sensitive parameters in common. A common subset of sensitive parameters is also shared among PFTs, but some parameters are specific to certain types (e.g., deciduous phenology). In conclusion, the relative importance of these parameters shifts significantly among PFTs and with climatic variables such as mean annual temperature.« less

  8. The Impact of Parametric Uncertainties on Biogeochemistry in the E3SM Land Model

    DOE PAGES

    Ricciuto, Daniel; Sargsyan, Khachik; Thornton, Peter

    2018-02-27

    We conduct a global sensitivity analysis (GSA) of the Energy Exascale Earth System Model (E3SM), land model (ELM) to calculate the sensitivity of five key carbon cycle outputs to 68 model parameters. This GSA is conducted by first constructing a Polynomial Chaos (PC) surrogate via new Weighted Iterative Bayesian Compressive Sensing (WIBCS) algorithm for adaptive basis growth leading to a sparse, high-dimensional PC surrogate with 3,000 model evaluations. The PC surrogate allows efficient extraction of GSA information leading to further dimensionality reduction. The GSA is performed at 96 FLUXNET sites covering multiple plant functional types (PFTs) and climate conditions. Aboutmore » 20 of the model parameters are identified as sensitive with the rest being relatively insensitive across all outputs and PFTs. These sensitivities are dependent on PFT, and are relatively consistent among sites within the same PFT. The five model outputs have a majority of their highly sensitive parameters in common. A common subset of sensitive parameters is also shared among PFTs, but some parameters are specific to certain types (e.g., deciduous phenology). In conclusion, the relative importance of these parameters shifts significantly among PFTs and with climatic variables such as mean annual temperature.« less

  9. A Taylor Expansion-Based Adaptive Design Strategy for Global Surrogate Modeling With Applications in Groundwater Modeling

    NASA Astrophysics Data System (ADS)

    Mo, Shaoxing; Lu, Dan; Shi, Xiaoqing; Zhang, Guannan; Ye, Ming; Wu, Jianfeng; Wu, Jichun

    2017-12-01

    Global sensitivity analysis (GSA) and uncertainty quantification (UQ) for groundwater modeling are challenging because of the model complexity and significant computational requirements. To reduce the massive computational cost, a cheap-to-evaluate surrogate model is usually constructed to approximate and replace the expensive groundwater models in the GSA and UQ. Constructing an accurate surrogate requires actual model simulations on a number of parameter samples. Thus, a robust experimental design strategy is desired to locate informative samples so as to reduce the computational cost in surrogate construction and consequently to improve the efficiency in the GSA and UQ. In this study, we develop a Taylor expansion-based adaptive design (TEAD) that aims to build an accurate global surrogate model with a small training sample size. TEAD defines a novel hybrid score function to search informative samples, and a robust stopping criterion to terminate the sample search that guarantees the resulted approximation errors satisfy the desired accuracy. The good performance of TEAD in building global surrogate models is demonstrated in seven analytical functions with different dimensionality and complexity in comparison to two widely used experimental design methods. The application of the TEAD-based surrogate method in two groundwater models shows that the TEAD design can effectively improve the computational efficiency of GSA and UQ for groundwater modeling.

  10. 77 FR 5020 - General Services Administration Acquisition Regulation; Information Collection; GSA Form 527...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-0007; Docket 2011-0001; Sequence 12] General Services Administration Acquisition Regulation; Information Collection; GSA Form 527, Contractor's Qualifications and Financial Information AGENCY: Office of the Chief Finance Officer, GSA. ACTION: Notice of...

  11. 41 CFR 101-39.202 - Contractor authorized services.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services... related GSA Interagency Fleet Management System (IFMS) services solely for official purposes. (b) To the... -leased equipment which is not controlled by a GSA IFMS fleet management center, or for authorized...

  12. 41 CFR 101-30.101-17 - Supply support.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....101-17 Section 101-30.101-17 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...; e.g., GSA stock program, Federal supply schedule program, GSA's buy-on-demand program, or GSA's...

  13. 41 CFR 101-30.101-17 - Supply support.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....101-17 Section 101-30.101-17 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...; e.g., GSA stock program, Federal supply schedule program, GSA's buy-on-demand program, or GSA's...

  14. 41 CFR 101-30.601 - Objective.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.601 Objective. GSA supply catalogs are primarily designed to... facilities by Federal civilian agencies and other organizations authorized to use the GSA Federal Supply...

  15. 41 CFR 101-30.601 - Objective.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.601 Objective. GSA supply catalogs are primarily designed to... facilities by Federal civilian agencies and other organizations authorized to use the GSA Federal Supply...

  16. 41 CFR 101-30.601 - Objective.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.601 Objective. GSA supply catalogs are primarily designed to... facilities by Federal civilian agencies and other organizations authorized to use the GSA Federal Supply...

  17. 41 CFR 101-30.601 - Objective.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.601 Objective. GSA supply catalogs are primarily designed to... facilities by Federal civilian agencies and other organizations authorized to use the GSA Federal Supply...

  18. 41 CFR 101-30.101-17 - Supply support.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....101-17 Section 101-30.101-17 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...; e.g., GSA stock program, Federal supply schedule program, GSA's buy-on-demand program, or GSA's...

  19. 41 CFR 101-30.101-17 - Supply support.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....101-17 Section 101-30.101-17 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...; e.g., GSA stock program, Federal supply schedule program, GSA's buy-on-demand program, or GSA's...

  20. 41 CFR 101-30.101-17 - Supply support.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....101-17 Section 101-30.101-17 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...; e.g., GSA stock program, Federal supply schedule program, GSA's buy-on-demand program, or GSA's...

  1. 41 CFR 101-30.601 - Objective.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.601 Objective. GSA supply catalogs are primarily designed to... facilities by Federal civilian agencies and other organizations authorized to use the GSA Federal Supply...

  2. 76 FR 41179 - Federal Acquisition Regulation; Biobased Procurements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... Services Administration (GSA), and National Aeronautics and Space Administration (NASA). ACTION: Proposed rule. SUMMARY: DoD, GSA, and NASA are proposing to amend the Federal Acquisition Regulation (FAR) to.... SUPPLEMENTARY INFORMATION: I. Background DoD, GSA, and NASA are proposing to amend the Federal Acquisition...

  3. 41 CFR 101-39.303 - Maintenance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System Vehicles § 101-39.303...) vehicles, safety and preventive maintenance inspections will be performed at regularly scheduled intervals as directed by GSA. Users of GSA IFMS vehicles shall comply with the safety and preventive...

  4. GSA-1/ARG1 protects root gravitropism in Arabidopsis under ammonium stress.

    PubMed

    Zou, Na; Li, Baohai; Chen, Hao; Su, Yanhua; Kronzucker, Herbert J; Xiong, Liming; Baluška, František; Shi, Weiming

    2013-10-01

    Gravitropism plays a critical role in plant growth and development, plant stability and acclimation to changes in water and nutrient availability. Ammonium (NH4(+)) is well known to have profound effects on root growth, but its impacts on gravitropism are poorly understood. To determine which genes are essential for the maintenance of root gravitropism under NH4(+) stress, we isolated and identified an NH4 (+)-sensitive mutant, gsa-1 (gravitropism sensitive to ammonium-1), in Arabidopsis thaliana, using an agar plate root reorientation assay. We found that, under NH4(+) stress, gsa-1 displayed increased loss of root gravitropism. Gene cloning and sequencing revealed that gsa-1 contains a G to C transversion mutation at the highly conserved 5'-GT splice position of intron 10 of ARG1 (ALTERED RESPONSE TO GRAVITY1), known to participate in the transduction of the root gravity signal. Genetic complement tests established the locus of GSA-1/ARG1 and its role in resistance to NH4 (+) inhibition on root gravitropism. GSA-1/ARG1 is required for normal AUX1 expression and basipetal auxin transport in root apices. In addition, PIN-FORMED2 (PIN2) is proposed as a target in the reduction of root gravitropism under NH4(+) stress, a response which can be antagonized by the GSA-1/ARG1-dependent pathway. These results suggest that GSA-1/ARG1 protects root gravitropism in Arabidopsis thaliana under ammonium stress. © 2013 The Authors. New Phytologist © 2013 New Phytologist Trust.

  5. 48 CFR 208.7002 - Assignment authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Secretary of Defense (Logistics); (2) To GSA, through agreement with GSA, by the Deputy Under Secretary of Defense (Logistics); (3) Outside the contiguous United States, by the Unified Commanders; and (4) For... Deputy Under Secretary of Defense (Logistics)— (1) To the departments and agencies; and (2) To GSA...

  6. 41 CFR 105-60.403 - Appeal within GSA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...) An appeal must be in writing and include a brief statement of the reasons he or she thinks GSA should... circumstances. GSA will process appeals of denials of expedited processing as soon as possible after receiving...

  7. Composite analysis E-area vaults and saltstone disposal facilities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cook, J.R.

    1997-09-01

    This report documents the Composite Analysis (CA) performed on the two active Savannah River Site (SRS) low-level radioactive waste (LLW) disposal facilities. The facilities are the Z-Area Saltstone Disposal Facility and the E-Area Vaults (EAV) Disposal Facility. The analysis calculated potential releases to the environment from all sources of residual radioactive material expected to remain in the General Separations Area (GSA). The GSA is the central part of SRS and contains all of the waste disposal facilities, chemical separations facilities and associated high-level waste storage facilities as well as numerous other sources of radioactive material. The analysis considered 114 potentialmore » sources of radioactive material containing 115 radionuclides. The results of the CA clearly indicate that continued disposal of low-level waste in the saltstone and EAV facilities, consistent with their respective radiological performance assessments, will have no adverse impact on future members of the public.« less

  8. Uncertainty analysis and global sensitivity analysis of techno-economic assessments for biodiesel production.

    PubMed

    Tang, Zhang-Chun; Zhenzhou, Lu; Zhiwen, Liu; Ningcong, Xiao

    2015-01-01

    There are various uncertain parameters in the techno-economic assessments (TEAs) of biodiesel production, including capital cost, interest rate, feedstock price, maintenance rate, biodiesel conversion efficiency, glycerol price and operating cost. However, fewer studies focus on the influence of these parameters on TEAs. This paper investigated the effects of these parameters on the life cycle cost (LCC) and the unit cost (UC) in the TEAs of biodiesel production. The results show that LCC and UC exhibit variations when involving uncertain parameters. Based on the uncertainty analysis, three global sensitivity analysis (GSA) methods are utilized to quantify the contribution of an individual uncertain parameter to LCC and UC. The GSA results reveal that the feedstock price and the interest rate produce considerable effects on the TEAs. These results can provide a useful guide for entrepreneurs when they plan plants. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Using global sensitivity analysis to understand higher order interactions in complex models: an application of GSA on the Revised Universal Soil Loss Equation (RUSLE) to quantify model sensitivity and implications for ecosystem services management in Costa Rica

    NASA Astrophysics Data System (ADS)

    Fremier, A. K.; Estrada Carmona, N.; Harper, E.; DeClerck, F.

    2011-12-01

    Appropriate application of complex models to estimate system behavior requires understanding the influence of model structure and parameter estimates on model output. To date, most researchers perform local sensitivity analyses, rather than global, because of computational time and quantity of data produced. Local sensitivity analyses are limited in quantifying the higher order interactions among parameters, which could lead to incomplete analysis of model behavior. To address this concern, we performed a GSA on a commonly applied equation for soil loss - the Revised Universal Soil Loss Equation. USLE is an empirical model built on plot-scale data from the USA and the Revised version (RUSLE) includes improved equations for wider conditions, with 25 parameters grouped into six factors to estimate long-term plot and watershed scale soil loss. Despite RUSLE's widespread application, a complete sensitivity analysis has yet to be performed. In this research, we applied a GSA to plot and watershed scale data from the US and Costa Rica to parameterize the RUSLE in an effort to understand the relative importance of model factors and parameters across wide environmental space. We analyzed the GSA results using Random Forest, a statistical approach to evaluate parameter importance accounting for the higher order interactions, and used Classification and Regression Trees to show the dominant trends in complex interactions. In all GSA calculations the management of cover crops (C factor) ranks the highest among factors (compared to rain-runoff erosivity, topography, support practices, and soil erodibility). This is counter to previous sensitivity analyses where the topographic factor was determined to be the most important. The GSA finding is consistent across multiple model runs, including data from the US, Costa Rica, and a synthetic dataset of the widest theoretical space. The three most important parameters were: Mass density of live and dead roots found in the upper inch of soil (C factor), slope angle (L and S factor), and percentage of land area covered by surface cover (C factor). Our findings give further support to the importance of vegetation as a vital ecosystem service provider - soil loss reduction. Concurrent, progress is already been made in Costa Rica, where dam managers are moving forward on a Payment for Ecosystem Services scheme to help keep private lands forested and to improve crop management through targeted investments. Use of complex watershed models, such as RUSLE can help managers quantify the effect of specific land use changes. Moreover, effective land management of vegetation has other important benefits, such as bundled ecosystem services (e.g. pollination, habitat connectivity, etc) and improvements of communities' livelihoods.

  10. NAICS Impact on Small Business Set-Asides

    DTIC Science & Technology

    2014-12-01

    APPENDIX C. AIRFIELD DEMOLITION SOLICITATION ...............................83 APPENDIX D. HAZARDOUS AND TOXIC WASTE REMOVAL SOLICITATION...Suitability for Transfer GPE government-wide point of entry GSA General Services Administration HTW hazardous and toxic waste HUBZone...Oilseed (except Soybean) Farming $0.75 111130 Dry Pea and Bean Farming $0.75 Subsector 112 – Animal Production 112111 Beef Cattle

  11. 41 CFR 101-27.500 - Scope and applicability of subpart.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MANAGEMENT 27.5-Return of GSA Stock Items § 101-27.500 Scope and applicability of subpart. This subpart sets... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope and applicability of subpart. 101-27.500 Section 101-27.500 Public Contracts and Property Management Federal Property...

  12. 41 CFR 102-33.40 - What are GSA's responsibilities for Federal aviation management?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... responsibilities for Federal aviation management? 102-33.40 Section 102-33.40 Public Contracts and Property... GSA's responsibilities for Federal aviation management? Under OMB Circular A-126, “Improving the.../omb), GSA's chief responsibilities for Federal aviation management are to maintain— (a) A single...

  13. 41 CFR 102-33.40 - What are GSA's responsibilities for Federal aviation management?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... responsibilities for Federal aviation management? 102-33.40 Section 102-33.40 Public Contracts and Property... GSA's responsibilities for Federal aviation management? Under OMB Circular A-126, “Improving the.../omb), GSA's chief responsibilities for Federal aviation management are to maintain— (a) A single...

  14. 41 CFR 102-33.40 - What are GSA's responsibilities for Federal aviation management?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... responsibilities for Federal aviation management? 102-33.40 Section 102-33.40 Public Contracts and Property... GSA's responsibilities for Federal aviation management? Under OMB Circular A-126, “Improving the.../omb), GSA's chief responsibilities for Federal aviation management are to maintain— (a) A single...

  15. 41 CFR 102-33.40 - What are GSA's responsibilities for Federal aviation management?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... responsibilities for Federal aviation management? 102-33.40 Section 102-33.40 Public Contracts and Property... GSA's responsibilities for Federal aviation management? Under OMB Circular A-126, “Improving the.../omb), GSA's chief responsibilities for Federal aviation management are to maintain— (a) A single...

  16. 41 CFR 101-25.203 - Centralized purchases by GSA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Centralized purchases by...-Interagency Purchase Assignments § 101-25.203 Centralized purchases by GSA. GSA will exclusively, or with specified limited exceptions, make purchases and contracts on a continuing basis for articles and services...

  17. 41 CFR 101-27.504 - Notice to GSA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Notice to GSA. 101-27.504 Section 101-27.504 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 27-INVENTORY MANAGEMENT 27.5-Return of GSA...

  18. 77 FR 15759 - Information Collection; Federal Management Regulation; GSA Form 3040, State Agency Monthly...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ...] Information Collection; Federal Management Regulation; GSA Form 3040, State Agency Monthly Donation Report of... regarding GSA Form 3040, State Agency Monthly Donation Report of Surplus Property. Public comments are..., State Agency Monthly Donation Report of Surplus Personal Property by any of the following methods...

  19. 41 CFR 101-28.306-4 - Expiration or cancellation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... time unless canceled by the Commissioner, FSS, GSA, or by a GSA Regional Administrator. (b) CSC... in organization or accounting structures that might have an impact on their CSC accounts. (d) The... cancellations may be directed by the GSA Regional Administrator in coordination with FSS Central Office. Under...

  20. 41 CFR 101-28.306-4 - Expiration or cancellation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... time unless canceled by the Commissioner, FSS, GSA, or by a GSA Regional Administrator. (b) CSC... in organization or accounting structures that might have an impact on their CSC accounts. (d) The... cancellations may be directed by the GSA Regional Administrator in coordination with FSS Central Office. Under...

  1. 41 CFR 101-28.306-4 - Expiration or cancellation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... time unless canceled by the Commissioner, FSS, GSA, or by a GSA Regional Administrator. (b) CSC... in organization or accounting structures that might have an impact on their CSC accounts. (d) The... cancellations may be directed by the GSA Regional Administrator in coordination with FSS Central Office. Under...

  2. 41 CFR 102-118.395 - How long will GSA take to respond to a waiver request?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Prepayment Audits of Transportation Services Waivers from Mandatory Prepayment Audit § 102-118.395 How long will GSA take to respond to a waiver request? GSA will...

  3. 41 CFR 102-85.145 - When are customer agencies responsible for Rent charges?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; or (2) All other space: Either GSA's space charges for 4 months plus the cost of tenant improvements or GSA's actual costs, whichever is less. ... PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Rent Charges § 102-85.145 When are customer agencies...

  4. 41 CFR 101-39.208 - Vehicles removed from defined areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services... operated outside the geographical area served by the issuing GSA IFMS fleet management center. However... shall notify the issuing GSA IFMS fleet management center of the following: (1) The location at which...

  5. 41 CFR 101-39.204 - Obtaining motor vehicles for indefinite assignment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management... related services of the GSA Interagency Fleet Management System (IFMS) are provided to requesting agencies... have been consolidated into the supporting GSA IFMS fleet management center, and no agency-owned...

  6. 41 CFR 105-64.110 - When may GSA establish computer matching programs?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... computer matching programs? 105-64.110 Section 105-64.110 Public Contracts and Property Management Federal... GSA establish computer matching programs? (a) System managers will establish computer matching... direction of the GSA Data Integrity Board that will be established when and if computer matching programs...

  7. 41 CFR 105-64.110 - When may GSA establish computer matching programs?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... computer matching programs? 105-64.110 Section 105-64.110 Public Contracts and Property Management Federal... GSA establish computer matching programs? (a) System managers will establish computer matching... direction of the GSA Data Integrity Board that will be established when and if computer matching programs...

  8. 41 CFR 105-64.110 - When may GSA establish computer matching programs?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... computer matching programs? 105-64.110 Section 105-64.110 Public Contracts and Property Management Federal... GSA establish computer matching programs? (a) System managers will establish computer matching... direction of the GSA Data Integrity Board that will be established when and if computer matching programs...

  9. 78 FR 75483 - Federal Travel Regulation (FTR); Relocation Allowances; Commuted Rate

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ... Allowances; Commuted Rate AGENCY: Office of Governmentwide Policy (OGP), U.S. General Services Administration (GSA). ACTION: Final rule. SUMMARY: The GSA, OGP, is providing a workable commuted rate to be used by.... 5724(c) requires that GSA maintain a commuted rate incorporating all aspects of household goods...

  10. 41 CFR 105-64.110 - When may GSA establish computer matching programs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... computer matching programs? 105-64.110 Section 105-64.110 Public Contracts and Property Management Federal... GSA establish computer matching programs? (a) System managers will establish computer matching... direction of the GSA Data Integrity Board that will be established when and if computer matching programs...

  11. 41 CFR 105-64.110 - When may GSA establish computer matching programs?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... computer matching programs? 105-64.110 Section 105-64.110 Public Contracts and Property Management Federal... GSA establish computer matching programs? (a) System managers will establish computer matching... direction of the GSA Data Integrity Board that will be established when and if computer matching programs...

  12. a Gsa-Svm Hybrid System for Classification of Binary Problems

    NASA Astrophysics Data System (ADS)

    Sarafrazi, Soroor; Nezamabadi-pour, Hossein; Barahman, Mojgan

    2011-06-01

    This paperhybridizesgravitational search algorithm (GSA) with support vector machine (SVM) and made a novel GSA-SVM hybrid system to improve the classification accuracy in binary problems. GSA is an optimization heuristic toolused to optimize the value of SVM kernel parameter (in this paper, radial basis function (RBF) is chosen as the kernel function). The experimental results show that this newapproach can achieve high classification accuracy and is comparable to or better than the particle swarm optimization (PSO)-SVM and genetic algorithm (GA)-SVM, which are two hybrid systems for classification.

  13. Groundwater flow simulation of the Savannah River Site general separations area

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Flach, G.; Bagwell, L.; Bennett, P.

    The most recent groundwater flow model of the General Separations Area, Savannah River Site, is referred to as the “GSA/PORFLOW” model. GSA/PORFLOW was developed in 2004 by porting an existing General Separations Area groundwater flow model from the FACT code to the PORFLOW code. The preceding “GSA/FACT” model was developed in 1997 using characterization and monitoring data through the mid-1990’s. Both models were manually calibrated to field data. Significantly more field data have been acquired since the 1990’s and model calibration using mathematical optimization software has become routine and recommended practice. The current task involved updating the GSA/PORFLOW model usingmore » selected field data current through at least 2015, and use of the PEST code to calibrate the model and quantify parameter uncertainty. This new GSA groundwater flow model is named “GSA2016” in reference to the year in which most development occurred. The GSA2016 model update is intended to address issues raised by the DOE Low-Level Waste (LLW) Disposal Facility Federal Review Group (LFRG) in a 2008 review of the E-Area Performance Assessment, and by the Nuclear Regulatory Commission in reviews of tank closure and Saltstone Disposal Facility Performance Assessments.« less

  14. Global Sensitivity Analysis for Large-scale Socio-hydrological Models using the Cloud

    NASA Astrophysics Data System (ADS)

    Hu, Y.; Garcia-Cabrejo, O.; Cai, X.; Valocchi, A. J.; Dupont, B.

    2014-12-01

    In the context of coupled human and natural system (CHNS), incorporating human factors into water resource management provides us with the opportunity to understand the interactions between human and environmental systems. A multi-agent system (MAS) model is designed to couple with the physically-based Republican River Compact Administration (RRCA) groundwater model, in an attempt to understand the declining water table and base flow in the heavily irrigated Republican River basin. For MAS modelling, we defined five behavioral parameters (κ_pr, ν_pr, κ_prep, ν_prep and λ) to characterize the agent's pumping behavior given the uncertainties of the future crop prices and precipitation. κ and ν describe agent's beliefs in their prior knowledge of the mean and variance of crop prices (κ_pr, ν_pr) and precipitation (κ_prep, ν_prep), and λ is used to describe the agent's attitude towards the fluctuation of crop profits. Notice that these human behavioral parameters as inputs to the MAS model are highly uncertain and even not measurable. Thus, we estimate the influences of these behavioral parameters on the coupled models using Global Sensitivity Analysis (GSA). In this paper, we address two main challenges arising from GSA with such a large-scale socio-hydrological model by using Hadoop-based Cloud Computing techniques and Polynomial Chaos Expansion (PCE) based variance decomposition approach. As a result, 1,000 scenarios of the coupled models are completed within two hours with the Hadoop framework, rather than about 28days if we run those scenarios sequentially. Based on the model results, GSA using PCE is able to measure the impacts of the spatial and temporal variations of these behavioral parameters on crop profits and water table, and thus identifies two influential parameters, κ_pr and λ. The major contribution of this work is a methodological framework for the application of GSA in large-scale socio-hydrological models. This framework attempts to find a balance between the heavy computational burden regarding model execution and the number of model evaluations required in the GSA analysis, particularly through an organic combination of Hadoop-based Cloud Computing to efficiently evaluate the socio-hydrological model and PCE where the sensitivity indices are efficiently estimated from its coefficients.

  15. 41 CFR 105-64.107 - What standards of conduct apply to employees with privacy-related responsibilities?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.107 What standards of conduct apply to employees with privacy... training requirements. All such employees will follow GSA orders HCO 9297.1 GSA Data Release Policy, HCO...

  16. 41 CFR 101-27.209-1 - GSA stock items.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true GSA stock items. 101-27.209-1 Section 101-27.209-1 Public Contracts and Property Management Federal Property Management...-Management of Shelf-Life Materials § 101-27.209-1 GSA stock items. Shelf-life items that meet the criteria...

  17. 77 FR 39494 - Submission for OMB Review; Federal Management Regulation; GSA Form 3040, State Agency Monthly...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...] Submission for OMB Review; Federal Management Regulation; GSA Form 3040, State Agency Monthly Donation Report... collection requirement regarding GSA Form 3040, State Agency Monthly Donation Report of Surplus Property. A... Information Collection 3090- 0112, State Agency Monthly Donation Report of Surplus Personal Property by any of...

  18. 32 CFR 644.393 - Final report of excess to GSA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Final report of excess to GSA. 644.393 Section 644.393 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Predisposal Action § 644.393 Final report of excess to GSA. Where a...

  19. 32 CFR 644.393 - Final report of excess to GSA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Final report of excess to GSA. 644.393 Section 644.393 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal Predisposal Action § 644.393 Final report of excess to GSA. Where a...

  20. 77 FR 36543 - General Services Administration Acquisition Regulation (GSAR) Part 523; Information Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... handling of such items throughout GSA's supply chain system. The information is used in GSA warehouses, stored in an NSN database and provided to GSA customers. Non-Collection and/or a less frequently... any of the following methods: Regulations.gov : http://www.regulations.gov . Submit comments via the...

  1. 41 CFR 102-117.340 - What other types of assistance may GSA provide agencies in dealing with regulatory bodies?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... assistance may GSA provide agencies in dealing with regulatory bodies? 102-117.340 Section 102-117.340 Public... MANAGEMENT REGULATION TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Representation Before Regulatory Body... bodies? (a) GSA has oversight of all public utilities used by the Federal Government including...

  2. 41 CFR 102-83.45 - Where may Executive agencies find guidance on appealing GSA's decisions and recommendations...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... agencies find guidance on appealing GSA's decisions and recommendations concerning delineated areas? 102-83... System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 83-LOCATION OF SPACE Location of Space... recommendations concerning delineated areas? GSA's PBS provides guidance in its Customer Guide to Real Property on...

  3. 48 CFR 519.7009 - Application process.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7009 Application process. (a... 3695 to the GSA Mentor-Protégé Program Manager, at GSA Office of Small Business Utilization (E... active approved subcontracting plan (small business exempted) and the firm is eligible, as of the date of...

  4. 48 CFR 519.7009 - Application process.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7009 Application process. (a... 3695 to the GSA Mentor-Protégé Program Manager, at GSA Office of Small Business Utilization (E... active approved subcontracting plan (small business exempted) and the firm is eligible, as of the date of...

  5. 48 CFR 519.7009 - Application process.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7009 Application process. (a... 3695 to the GSA Mentor-Protégé Program Manager, at GSA Office of Small Business Utilization (E... active approved subcontracting plan (small business exempted) and the firm is eligible, as of the date of...

  6. 48 CFR 519.7009 - Application process.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7009 Application process. (a... 3695 to the GSA Mentor-Protégé Program Manager, at GSA Office of Small Business Utilization (E... active approved subcontracting plan (small business exempted) and the firm is eligible, as of the date of...

  7. 41 CFR 102-117.340 - What other types of assistance may GSA provide agencies in dealing with regulatory bodies?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assistance may GSA provide agencies in dealing with regulatory bodies? 102-117.340 Section 102-117.340 Public... MANAGEMENT REGULATION TRANSPORTATION 117-TRANSPORTATION MANAGEMENT Representation Before Regulatory Body... bodies? (a) GSA has oversight of all public utilities used by the Federal Government including...

  8. Global Sensitivity Analysis for the determination of parameter importance in bio-manufacturing processes.

    PubMed

    Chhatre, Sunil; Francis, Richard; Newcombe, Anthony R; Zhou, Yuhong; Titchener-Hooker, Nigel; King, Josh; Keshavarz-Moore, Eli

    2008-10-01

    The present paper describes the application of GSA (Global Sensitivity Analysis) techniques to mathematical models of bioprocesses in order to rank inputs such as feed titres, flow rates and matrix capacities for the relative influence that each exerts upon outputs such as yield or throughput. GSA enables quantification of both the impact of individual variables on process outputs, as well as their interactions. These data highlight those attributes of a bioprocess which offer the greatest potential for achieving manufacturing improvements. Whereas previous GSA studies have been limited to individual unit operations, this paper extends the treatment to an entire downstream process and illustrates its utility by application to the production of a Fab-based rattlesnake antivenom called CroFab [(Crotalidae Polyvalent Immune Fab (Ovine); Protherics U.K. Limited]. Initially, hyperimmunized ovine serum containing rattlesnake antivenom IgG (product), other antibodies and albumin is applied to a synthetic affinity ligand adsorbent column to separate the antibodies from the albumin. The antibodies are papain-digested into Fab and Fc fragments, before concentration by ultrafiltration. Fc, residual IgG and albumin are eliminated by an ion-exchanger and then CroFab-specific affinity chromatography is used to produce purified antivenom. Application of GSA to the model of this process showed that product yield was controlled by IgG feed concentration and the synthetic-material affinity column's capacity and flow rate, whereas product throughput was predominantly influenced by the synthetic material's capacity, the ultrafiltration concentration factor and the CroFab affinity flow rate. Such information provides a rational basis for identifying the most promising strategies for delivering improvements to commercial-scale biomanufacturing processes.

  9. A Taylor Expansion-Based Adaptive Design Strategy for Global Surrogate Modeling With Applications in Groundwater Modeling

    DOE PAGES

    Mo, Shaoxing; Lu, Dan; Shi, Xiaoqing; ...

    2017-12-27

    Global sensitivity analysis (GSA) and uncertainty quantification (UQ) for groundwater modeling are challenging because of the model complexity and significant computational requirements. To reduce the massive computational cost, a cheap-to-evaluate surrogate model is usually constructed to approximate and replace the expensive groundwater models in the GSA and UQ. Constructing an accurate surrogate requires actual model simulations on a number of parameter samples. Thus, a robust experimental design strategy is desired to locate informative samples so as to reduce the computational cost in surrogate construction and consequently to improve the efficiency in the GSA and UQ. In this study, we developmore » a Taylor expansion-based adaptive design (TEAD) that aims to build an accurate global surrogate model with a small training sample size. TEAD defines a novel hybrid score function to search informative samples, and a robust stopping criterion to terminate the sample search that guarantees the resulted approximation errors satisfy the desired accuracy. The good performance of TEAD in building global surrogate models is demonstrated in seven analytical functions with different dimensionality and complexity in comparison to two widely used experimental design methods. The application of the TEAD-based surrogate method in two groundwater models shows that the TEAD design can effectively improve the computational efficiency of GSA and UQ for groundwater modeling.« less

  10. A Taylor Expansion-Based Adaptive Design Strategy for Global Surrogate Modeling With Applications in Groundwater Modeling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mo, Shaoxing; Lu, Dan; Shi, Xiaoqing

    Global sensitivity analysis (GSA) and uncertainty quantification (UQ) for groundwater modeling are challenging because of the model complexity and significant computational requirements. To reduce the massive computational cost, a cheap-to-evaluate surrogate model is usually constructed to approximate and replace the expensive groundwater models in the GSA and UQ. Constructing an accurate surrogate requires actual model simulations on a number of parameter samples. Thus, a robust experimental design strategy is desired to locate informative samples so as to reduce the computational cost in surrogate construction and consequently to improve the efficiency in the GSA and UQ. In this study, we developmore » a Taylor expansion-based adaptive design (TEAD) that aims to build an accurate global surrogate model with a small training sample size. TEAD defines a novel hybrid score function to search informative samples, and a robust stopping criterion to terminate the sample search that guarantees the resulted approximation errors satisfy the desired accuracy. The good performance of TEAD in building global surrogate models is demonstrated in seven analytical functions with different dimensionality and complexity in comparison to two widely used experimental design methods. The application of the TEAD-based surrogate method in two groundwater models shows that the TEAD design can effectively improve the computational efficiency of GSA and UQ for groundwater modeling.« less

  11. 77 FR 8028 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... provides summary descriptions of regulations being developed by the Civilian Agency Acquisition Council and... Analysis Required: Yes. Agency Contact: Karlos Morgan, Procurement Analyst, DOD/GSA/NASA (FAR), 1275 First... 05/00/12 Regulatory Flexibility Analysis Required: Yes. Agency Contact: William Clark, Procurement...

  12. 48 CFR 519.7005 - Measurement of program success.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7005 Measurement of program success. The overall success of the GSA Mentor-Protégé Program encompassing all participating mentors and..., and percentage of subcontracts awarded to protégés by mentor firms under GSA contracts since the date...

  13. 41 CFR 101-26.509-2 - Requisitioning tabulating machine cards not available from Federal Supply Schedule contracts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.5-GSA Procurement... contracts will not adequately serve the end-use purpose. GSA will notify the requesting agency in writing of... in which the requisitioner is located. GSA will either arrange for procurement of the items or...

  14. 41 CFR 102-37.125 - What are some donations that do not require GSA's approval?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are some donations... PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Holding Agency § 102-37.125 What are some donations that do not require GSA's approval? (a) Some donations of surplus property that do not require GSA's...

  15. 41 CFR 102-37.125 - What are some donations that do not require GSA's approval?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What are some donations... PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Holding Agency § 102-37.125 What are some donations that do not require GSA's approval? (a) Some donations of surplus property that do not require GSA's...

  16. 41 CFR 102-37.125 - What are some donations that do not require GSA's approval?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What are some donations... PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Holding Agency § 102-37.125 What are some donations that do not require GSA's approval? (a) Some donations of surplus property that do not require GSA's...

  17. 41 CFR 102-37.125 - What are some donations that do not require GSA's approval?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What are some donations... PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Holding Agency § 102-37.125 What are some donations that do not require GSA's approval? (a) Some donations of surplus property that do not require GSA's...

  18. 41 CFR 102-37.125 - What are some donations that do not require GSA's approval?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What are some donations... PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Holding Agency § 102-37.125 What are some donations that do not require GSA's approval? (a) Some donations of surplus property that do not require GSA's...

  19. 76 FR 16629 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-24

    ... other FTR Bulletins can be found at http://www.gsa.gov/ftrbulletin . The RIT allowance tables are located at http://www.gsa.gov/relocationpolicy . DATES: This notice is effective March 24, 2011. FOR... CFR part 301-17 Appendices A through D. The tables will be published at http://www.gsa.gov...

  20. 77 FR 59925 - Public Buildings Service; Submission for OMB Review; Application/Permit for Use of Space in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... Buildings Service; Submission for OMB Review; Application/ Permit for Use of Space in Public Buildings and Grounds, GSA Form 3453 AGENCY: Public Buildings Service, GSA. ACTION: Notice of request for comments... regarding GSA Form 3453, Application/Permit for Use of Space in Public Buildings and Grounds. A notice was...

  1. 76 FR 13617 - Office of Federal High-Performance Green Buildings (OFHPGB); Notice of GSA Bulletin OFHPGB 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ...-Performance Green Buildings (OFHPGB); Notice of GSA Bulletin OFHPGB 2011-OGP-1 AGENCY: Office of.... Procedures Bulletins regarding the Office of Federal High-Performance Green Building are located on the... Washington, DC 20405 OFFICE OF FEDERAL HIGH-PERFORMANCE GREEN BUILDINGS GSA Bulletin 2011-OGP-1 TO: Heads of...

  2. 41 CFR 105-64.601 - Procedures for establishing system of records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Services Administration 64-GSA PRIVACY ACT RULES 64.6-Establishing or Revising Systems of Records in GSA... proposed new or revised system of records: (a) Before establishing a new or revising an existing system of... provide to the GSA Privacy Act Officer a proposal describing and justifying the new system or revision. (b...

  3. 41 CFR 105-64.406 - How will my appeal be handled?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administration 64-GSA PRIVACY ACT RULES 64.4-Amending Records § 105-64.406 How will my appeal be handled? The GSA Privacy Act Officer will consult with legal counsel and appropriate GSA officials concerning your appeal. If they decide to reject your appeal, the Privacy Act Officer will provide the Deputy Administrator...

  4. 75 FR 19168 - Federal Acquisition Regulation; FAR Case 2009-005, Use of Project Labor Agreements for Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    ... located on Indian reservations. Response: GSA, DoD, and NASA have clarified in the final rule that project... Administration (GSA), and National Aeronautics and Space Administration (NASA). ACTION: Final rule. SUMMARY: GSA, DOD, and NASA are issuing a final rule amending the Federal Acquisition Regulation (FAR) to implement...

  5. 41 CFR 102-75.145 - Is GSA required to review each report of excess?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... landholding agency, in writing, whether the report is acceptable or other information is needed within 15... review each report of excess? 102-75.145 Section 102-75.145 Public Contracts and Property Management... Is GSA required to review each report of excess? Yes, GSA must review each report of excess to...

  6. Data Management and Rescue at a State Geological Survey

    NASA Astrophysics Data System (ADS)

    Hills, D. J.; McIntyre-Redden, M. R.

    2015-12-01

    As new technologies are developed to utilize data more fully, and as shrinking budgets mean more needs to be done with less, well-documented and discoverable legacy data is vital for continued research and economic growth. Many governmental agencies are mandated to maintain scientific data, and the Geological Survey of Alabama (GSA) is no different. As part of the mandate to explore for, characterize, and report Alabama's mineral, energy, water, and biological resources for the betterment of Alabama's citizens, communities, and businesses, the GSA has increasingly been called upon to make our data (including samples) more accessible to stakeholders. The GSA has been involved in several data management, preservation, and rescue projects, including the National Geothermal Data System and the National Geological and Geophysical Data Preservation Program. GSA staff utilizes accepted standards for metadata, such as those found at the US Geoscience Information Network (USGIN). Through the use of semi-automated workflows, these standards can be applied to legacy data records. As demand for more detailed information on samples increases, especially so that a researcher can do a preliminary assessment prior to a site visit, it has become critical for the efficiency of the GSA to have better systems in place for sample tracking and data management. Thus, GSA is in the process of registering cores and related samples for International Geo Sample Numbers (IGSNs) through the System for Earth Sample Registration. IGSNs allow the GSA to use asset management software to better curate the physical samples and provide more accurate information to stakeholders. Working with other initiatives, such as EarthCube's iSamples project, will ensure that GSA continues to use best practices and standards for sample identification, documentation, citation, curation, and sharing.

  7. 48 CFR 339.7000 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Commercial Independent Risk Analysis Services Blanket Purchase Agreements (BPA), dated February 4, 2008, available on the OMB Web site. HHS policy is for contracting activities to use the GSA BPA sources to the...

  8. 48 CFR 339.7000 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Commercial Independent Risk Analysis Services Blanket Purchase Agreements (BPA), dated February 4, 2008, available on the OMB Web site. HHS policy is for contracting activities to use the GSA BPA sources to the...

  9. 48 CFR 339.7000 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Commercial Independent Risk Analysis Services Blanket Purchase Agreements (BPA), dated February 4, 2008, available on the OMB Web site. HHS policy is for contracting activities to use the GSA BPA sources to the...

  10. 48 CFR 339.7000 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Commercial Independent Risk Analysis Services Blanket Purchase Agreements (BPA), dated February 4, 2008, available on the OMB Web site. HHS policy is for contracting activities to use the GSA BPA sources to the...

  11. 48 CFR 339.7000 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Commercial Independent Risk Analysis Services Blanket Purchase Agreements (BPA), dated February 4, 2008, available on the OMB Web site. HHS policy is for contracting activities to use the GSA BPA sources to the...

  12. 41 CFR 102-192.90 - What must we include in our annual mail management report to GSA?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... our annual mail management report to GSA? 102-192.90 Section 102-192.90 Public Contracts and Property... annual mail management report to GSA? Your annual report must— (a) Identify your agency mail manager; in... person serving in this role. (b) State the total amounts paid to each service provider during the...

  13. 41 CFR 102-37.535 - What information must FAA provide to GSA on its administration of the public airport donation...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... FAA provide to GSA on its administration of the public airport donation program? 102-37.535 Section... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.535 What information must FAA provide to GSA on its administration of...

  14. 41 CFR 102-37.535 - What information must FAA provide to GSA on its administration of the public airport donation...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FAA provide to GSA on its administration of the public airport donation program? 102-37.535 Section... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.535 What information must FAA provide to GSA on its administration of...

  15. 41 CFR 102-37.535 - What information must FAA provide to GSA on its administration of the public airport donation...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... FAA provide to GSA on its administration of the public airport donation program? 102-37.535 Section... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.535 What information must FAA provide to GSA on its administration of...

  16. 41 CFR 102-37.535 - What information must FAA provide to GSA on its administration of the public airport donation...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FAA provide to GSA on its administration of the public airport donation program? 102-37.535 Section... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.535 What information must FAA provide to GSA on its administration of...

  17. 5 CFR 6701.104 - Prohibited purchases of real estate by certain GSA employees involved in the acquisition or...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Prohibited purchases of real estate by certain GSA employees involved in the acquisition or disposal of real estate. 6701.104 Section 6701.104... OF THE GENERAL SERVICES ADMINISTRATION § 6701.104 Prohibited purchases of real estate by certain GSA...

  18. 5 CFR 6701.104 - Prohibited purchases of real estate by certain GSA employees involved in the acquisition or...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Prohibited purchases of real estate by certain GSA employees involved in the acquisition or disposal of real estate. 6701.104 Section 6701.104... OF THE GENERAL SERVICES ADMINISTRATION § 6701.104 Prohibited purchases of real estate by certain GSA...

  19. 5 CFR 6701.104 - Prohibited purchases of real estate by certain GSA employees involved in the acquisition or...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Prohibited purchases of real estate by certain GSA employees involved in the acquisition or disposal of real estate. 6701.104 Section 6701.104... OF THE GENERAL SERVICES ADMINISTRATION § 6701.104 Prohibited purchases of real estate by certain GSA...

  20. 5 CFR 6701.104 - Prohibited purchases of real estate by certain GSA employees involved in the acquisition or...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Prohibited purchases of real estate by certain GSA employees involved in the acquisition or disposal of real estate. 6701.104 Section 6701.104... OF THE GENERAL SERVICES ADMINISTRATION § 6701.104 Prohibited purchases of real estate by certain GSA...

  1. 41 CFR 102-173.45 - Is there a registration charge for domain names?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.45 Is there a registration charge for domain names? The General... operations. For current registration charges, please visit the GSA Web site at http://www.nic.gov. GSA does... that may be provided by GSA, and a recurring annual charge that will not exceed $500 for all dot-gov...

  2. 41 CFR 102-173.45 - Is there a registration charge for domain names?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.45 Is there a registration charge for domain names? The General... operations. For current registration charges, please visit the GSA Web site at http://www.nic.gov. GSA does... that may be provided by GSA, and a recurring annual charge that will not exceed $500 for all dot-gov...

  3. 41 CFR 102-173.45 - Is there a registration charge for domain names?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.45 Is there a registration charge for domain names? The General... operations. For current registration charges, please visit the GSA Web site at http://www.nic.gov. GSA does... that may be provided by GSA, and a recurring annual charge that will not exceed $500 for all dot-gov...

  4. 41 CFR 102-173.45 - Is there a registration charge for domain names?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.45 Is there a registration charge for domain names? The General... operations. For current registration charges, please visit the GSA Web site at http://www.nic.gov. GSA does... that may be provided by GSA, and a recurring annual charge that will not exceed $500 for all dot-gov...

  5. 41 CFR 102-173.45 - Is there a registration charge for domain names?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-INTERNET GOV DOMAIN Registration § 102-173.45 Is there a registration charge for domain names? The General... operations. For current registration charges, please visit the GSA Web site at http://www.nic.gov. GSA does... that may be provided by GSA, and a recurring annual charge that will not exceed $500 for all dot-gov...

  6. 41 CFR 102-2.85 - What are the reasons for writing to GSA about FMR deviations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are the reasons for... MANAGEMENT REGULATION SYSTEM Regulation System Deviations § 102-2.85 What are the reasons for writing to GSA... clarification from GSA as to whether statutes, Executive orders, or other controlling policies, which may not be...

  7. Aircraft Engine Thrust Estimator Design Based on GSA-LSSVM

    NASA Astrophysics Data System (ADS)

    Sheng, Hanlin; Zhang, Tianhong

    2017-08-01

    In view of the necessity of highly precise and reliable thrust estimator to achieve direct thrust control of aircraft engine, based on support vector regression (SVR), as well as least square support vector machine (LSSVM) and a new optimization algorithm - gravitational search algorithm (GSA), by performing integrated modelling and parameter optimization, a GSA-LSSVM-based thrust estimator design solution is proposed. The results show that compared to particle swarm optimization (PSO) algorithm, GSA can find unknown optimization parameter better and enables the model developed with better prediction and generalization ability. The model can better predict aircraft engine thrust and thus fulfills the need of direct thrust control of aircraft engine.

  8. Global sensitivity analysis for urban water quality modelling: Terminology, convergence and comparison of different methods

    NASA Astrophysics Data System (ADS)

    Vanrolleghem, Peter A.; Mannina, Giorgio; Cosenza, Alida; Neumann, Marc B.

    2015-03-01

    Sensitivity analysis represents an important step in improving the understanding and use of environmental models. Indeed, by means of global sensitivity analysis (GSA), modellers may identify both important (factor prioritisation) and non-influential (factor fixing) model factors. No general rule has yet been defined for verifying the convergence of the GSA methods. In order to fill this gap this paper presents a convergence analysis of three widely used GSA methods (SRC, Extended FAST and Morris screening) for an urban drainage stormwater quality-quantity model. After the convergence was achieved the results of each method were compared. In particular, a discussion on peculiarities, applicability, and reliability of the three methods is presented. Moreover, a graphical Venn diagram based classification scheme and a precise terminology for better identifying important, interacting and non-influential factors for each method is proposed. In terms of convergence, it was shown that sensitivity indices related to factors of the quantity model achieve convergence faster. Results for the Morris screening method deviated considerably from the other methods. Factors related to the quality model require a much higher number of simulations than the number suggested in literature for achieving convergence with this method. In fact, the results have shown that the term "screening" is improperly used as the method may exclude important factors from further analysis. Moreover, for the presented application the convergence analysis shows more stable sensitivity coefficients for the Extended-FAST method compared to SRC and Morris screening. Substantial agreement in terms of factor fixing was found between the Morris screening and Extended FAST methods. In general, the water quality related factors exhibited more important interactions than factors related to water quantity. Furthermore, in contrast to water quantity model outputs, water quality model outputs were found to be characterised by high non-linearity.

  9. What Constitutes a "Good" Sensitivity Analysis? Elements and Tools for a Robust Sensitivity Analysis with Reduced Computational Cost

    NASA Astrophysics Data System (ADS)

    Razavi, Saman; Gupta, Hoshin; Haghnegahdar, Amin

    2016-04-01

    Global sensitivity analysis (GSA) is a systems theoretic approach to characterizing the overall (average) sensitivity of one or more model responses across the factor space, by attributing the variability of those responses to different controlling (but uncertain) factors (e.g., model parameters, forcings, and boundary and initial conditions). GSA can be very helpful to improve the credibility and utility of Earth and Environmental System Models (EESMs), as these models are continually growing in complexity and dimensionality with continuous advances in understanding and computing power. However, conventional approaches to GSA suffer from (1) an ambiguous characterization of sensitivity, and (2) poor computational efficiency, particularly as the problem dimension grows. Here, we identify several important sensitivity-related characteristics of response surfaces that must be considered when investigating and interpreting the ''global sensitivity'' of a model response (e.g., a metric of model performance) to its parameters/factors. Accordingly, we present a new and general sensitivity and uncertainty analysis framework, Variogram Analysis of Response Surfaces (VARS), based on an analogy to 'variogram analysis', that characterizes a comprehensive spectrum of information on sensitivity. We prove, theoretically, that Morris (derivative-based) and Sobol (variance-based) methods and their extensions are special cases of VARS, and that their SA indices are contained within the VARS framework. We also present a practical strategy for the application of VARS to real-world problems, called STAR-VARS, including a new sampling strategy, called "star-based sampling". Our results across several case studies show the STAR-VARS approach to provide reliable and stable assessments of "global" sensitivity, while being at least 1-2 orders of magnitude more efficient than the benchmark Morris and Sobol approaches.

  10. Understanding earth system models: how Global Sensitivity Analysis can help

    NASA Astrophysics Data System (ADS)

    Pianosi, Francesca; Wagener, Thorsten

    2017-04-01

    Computer models are an essential element of earth system sciences, underpinning our understanding of systems functioning and influencing the planning and management of socio-economic-environmental systems. Even when these models represent a relatively low number of physical processes and variables, earth system models can exhibit a complicated behaviour because of the high level of interactions between their simulated variables. As the level of these interactions increases, we quickly lose the ability to anticipate and interpret the model's behaviour and hence the opportunity to check whether the model gives the right response for the right reasons. Moreover, even if internally consistent, an earth system model will always produce uncertain predictions because it is often forced by uncertain inputs (due to measurement errors, pre-processing uncertainties, scarcity of measurements, etc.). Lack of transparency about the scope of validity, limitations and the main sources of uncertainty of earth system models can be a strong limitation to their effective use for both scientific and decision-making purposes. Global Sensitivity Analysis (GSA) is a set of statistical analysis techniques to investigate the complex behaviour of earth system models in a structured, transparent and comprehensive way. In this presentation, we will use a range of examples across earth system sciences (with a focus on hydrology) to demonstrate how GSA is a fundamental element in advancing the construction and use of earth system models, including: verifying the consistency of the model's behaviour with our conceptual understanding of the system functioning; identifying the main sources of output uncertainty so to focus efforts for uncertainty reduction; finding tipping points in forcing inputs that, if crossed, would bring the system to specific conditions we want to avoid.

  11. Integrated Hydrogeological Model of the General Separations Area, Vol. 2, Rev. 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    FLACH, GREGORYK.

    1999-04-01

    The 15 mi2 General Separations Area (GSA) contains more than 35 RCRA and CERCLA waste units, and is the focus of numerous ongoing and anticipated contaminant migration and remedial alternatives studies. To meet the analysis needs of GSA remediation programs, a groundwater flow model of the area based on the FACT code was developed. The model is consistent with detailed characterization and monitoring data through 1996. Model preprocessing has been automated so that future updates and modifications can be performed quickly and efficiently. Most remedial action scenarios can be explicitly simulated, including vertical recirculation wells, vertical barriers, surface caps, pumpingmore » wells at arbitrary locations, specified drawdown within well casings (instead of flowrate), and wetland impacts of remedial actions. The model has a fine scale vertical mesh and heterogeneous conductivity field, and includes the vadose zone. Therefore, the model is well suited to support subsequent contaminant transport simulations. the model can provide a common framework for analyzing groundwater flow, contaminant migration, and remedial alternatives across Environmental Restoration programs within the GSA.« less

  12. 41 CFR 102-37.535 - What information must FAA provide to GSA on its administration of the public airport donation...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What information must FAA provide to GSA on its administration of the public airport donation program? 102-37.535 Section... Donations to Public Airports § 102-37.535 What information must FAA provide to GSA on its administration of...

  13. 41 CFR 102-41.205 - Do we report all forfeited distilled spirits, wine, and beer to GSA for disposal?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... forfeited distilled spirits, wine, and beer to GSA for disposal? 102-41.205 Section 102-41.205 Public..., and Beer § 102-41.205 Do we report all forfeited distilled spirits, wine, and beer to GSA for disposal? (a) Yes, except do not report distilled spirits, wine, and beer not fit for human consumption or for...

  14. 41 CFR 102-41.205 - Do we report all forfeited distilled spirits, wine, and beer to GSA for disposal?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... forfeited distilled spirits, wine, and beer to GSA for disposal? 102-41.205 Section 102-41.205 Public..., and Beer § 102-41.205 Do we report all forfeited distilled spirits, wine, and beer to GSA for disposal? (a) Yes, except do not report distilled spirits, wine, and beer not fit for human consumption or for...

  15. 41 CFR 102-41.205 - Do we report all forfeited distilled spirits, wine, and beer to GSA for disposal?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... forfeited distilled spirits, wine, and beer to GSA for disposal? 102-41.205 Section 102-41.205 Public..., and Beer § 102-41.205 Do we report all forfeited distilled spirits, wine, and beer to GSA for disposal? (a) Yes, except do not report distilled spirits, wine, and beer not fit for human consumption or for...

  16. 41 CFR 300-80.4 - How many test programs may be authorized by GSA throughout the government?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false How many test programs may be authorized by GSA throughout the government? 300-80.4 Section 300-80.4 Public Contracts and... TEST PROGRAMS § 300-80.4 How many test programs may be authorized by GSA throughout the government? No...

  17. TELECOMMUNICATIONS. GSA Action Needed to Realize Benefits of Metropolitan Area Acquisition Program

    DTIC Science & Technology

    2002-04-01

    Reform, House of RepresentativesApril 2002 TELECOMMUNICATIONS GSA Action Needed to Realize Benefits of Metropolitan Area Acquisition Programa GAO-02...Needed to Realize Benefits of Metropolitan Area Acquisition Program Contract Number Grant Number Program Element Number Author(s) Project Number...TELECOMMUNICATIONS GSA Action Needed to Realize Benefits of Metropolitan Area Acquisition Program This is a test for developing highlights for a GAO report

  18. 41 CFR 102-36.395 - How may GSA assist us in disposing of foreign excess personal property?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false How may GSA assist us in disposing of foreign excess personal property? 102-36.395 Section 102-36.395 Public Contracts and Property... Handling Foreign Excess Personal Property § 102-36.395 How may GSA assist us in disposing of foreign excess...

  19. 41 CFR 102-36.395 - How may GSA assist us in disposing of foreign excess personal property?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How may GSA assist us in disposing of foreign excess personal property? 102-36.395 Section 102-36.395 Public Contracts and Property... Handling Foreign Excess Personal Property § 102-36.395 How may GSA assist us in disposing of foreign excess...

  20. Moment-based metrics for global sensitivity analysis of hydrological systems

    NASA Astrophysics Data System (ADS)

    Dell'Oca, Aronne; Riva, Monica; Guadagnini, Alberto

    2017-12-01

    We propose new metrics to assist global sensitivity analysis, GSA, of hydrological and Earth systems. Our approach allows assessing the impact of uncertain parameters on main features of the probability density function, pdf, of a target model output, y. These include the expected value of y, the spread around the mean and the degree of symmetry and tailedness of the pdf of y. Since reliable assessment of higher-order statistical moments can be computationally demanding, we couple our GSA approach with a surrogate model, approximating the full model response at a reduced computational cost. Here, we consider the generalized polynomial chaos expansion (gPCE), other model reduction techniques being fully compatible with our theoretical framework. We demonstrate our approach through three test cases, including an analytical benchmark, a simplified scenario mimicking pumping in a coastal aquifer and a laboratory-scale conservative transport experiment. Our results allow ascertaining which parameters can impact some moments of the model output pdf while being uninfluential to others. We also investigate the error associated with the evaluation of our sensitivity metrics by replacing the original system model through a gPCE. Our results indicate that the construction of a surrogate model with increasing level of accuracy might be required depending on the statistical moment considered in the GSA. The approach is fully compatible with (and can assist the development of) analysis techniques employed in the context of reduction of model complexity, model calibration, design of experiment, uncertainty quantification and risk assessment.

  1. LPTA Versus Tradeoff: How Procurement Methods Can Impact Contract Performance

    DTIC Science & Technology

    2015-06-01

    and Technology BBP Better Buying Power BPA Blanket Purchase Agreement CAR Contract Action Report COR Contracting Officer’s...Blanket Purchase Agreements ( BPAs ), which utilize streamlined contracting in the form of orders to award requirements faster. Under IDIQs, GSA vehicles...and BPA agreements the rates are typically pre-negotiated with the set of vendors, leaving little necessity for negotiation and tradeoff tactics

  2. Greater Engagement among Members of Gay-Straight Alliances: Individual and Structural Contributors

    ERIC Educational Resources Information Center

    Poteat, V. Paul; Heck, Nicholas C.; Yoshikawa, Hirokazu; Calzo, Jerel P.

    2016-01-01

    Using youth program models to frame the study of Gay-Straight Alliances (GSAs), we identified individual and structural predictors of greater engagement in these settings with a cross-sectional sample of 295 youth in 33 GSAs from the 2014 Massachusetts GSA Network Survey (69% LGBQ, 68% cisgender female, 68% White, M[subscript age] =16.07).…

  3. Saltelli Global Sensitivity Analysis and Simulation Modelling to Identify Intervention Strategies to Reduce the Prevalence of Escherichia coli O157 Contaminated Beef Carcasses

    PubMed Central

    Brookes, Victoria J.; Jordan, David; Davis, Stephen; Ward, Michael P.; Heller, Jane

    2015-01-01

    Introduction Strains of Shiga-toxin producing Escherichia coli O157 (STEC O157) are important foodborne pathogens in humans, and outbreaks of illness have been associated with consumption of undercooked beef. Here, we determine the most effective intervention strategies to reduce the prevalence of STEC O157 contaminated beef carcasses using a modelling approach. Method A computational model simulated events and processes in the beef harvest chain. Information from empirical studies was used to parameterise the model. Variance-based global sensitivity analysis (GSA) using the Saltelli method identified variables with the greatest influence on the prevalence of STEC O157 contaminated carcasses. Following a baseline scenario (no interventions), a series of simulations systematically introduced and tested interventions based on influential variables identified by repeated Saltelli GSA, to determine the most effective intervention strategy. Results Transfer of STEC O157 from hide or gastro-intestinal tract to carcass (improved abattoir hygiene) had the greatest influence on the prevalence of contaminated carcases. Due to interactions between inputs (identified by Saltelli GSA), combinations of interventions based on improved abattoir hygiene achieved a greater reduction in maximum prevalence than would be expected from an additive effect of single interventions. The most effective combination was improved abattoir hygiene with vaccination, which achieved a greater than ten-fold decrease in maximum prevalence compared to the baseline scenario. Conclusion Study results suggest that effective interventions to reduce the prevalence of STEC O157 contaminated carcasses should initially be based on improved abattoir hygiene. However, the effect of improved abattoir hygiene on the distribution of STEC O157 concentration on carcasses is an important information gap—further empirical research is required to determine whether reduced prevalence of contaminated carcasses is likely to result in reduced incidence of STEC O157 associated illness in humans. This is the first use of variance-based GSA to assess the drivers of STEC O157 contamination of beef carcasses. PMID:26713610

  4. Content Model Use and Development to Redeem Thin Section Records

    NASA Astrophysics Data System (ADS)

    Hills, D. J.

    2014-12-01

    The National Geothermal Data System (NGDS) is a catalog of documents and datasets that provide information about geothermal resources located primarily within the United States. The goal of NGDS is to make large quantities of geothermal-relevant geoscience data available to the public by creating a national, sustainable, distributed, and interoperable network of data providers. The Geological Survey of Alabama (GSA) has been a data provider in the initial phase of NGDS. One method by which NGDS facilitates interoperability is through the use of content models. Content models provide a schema (structure) for submitted data. Schemas dictate where and how data should be entered. Content models use templates that simplify data formatting to expedite use by data providers. These methodologies implemented by NGDS can extend beyond geothermal data to all geoscience data. The GSA, using the NGDS physical samples content model, has tested and refined a content model for thin sections and thin section photos. Countless thin sections have been taken from oil and gas well cores housed at the GSA, and many of those thin sections have related photomicrographs. Record keeping for these thin sections has been scattered at best, and it is critical to capture their metadata while the content creators are still available. A next step will be to register the GSA's thin sections with SESAR (System for Earth Sample Registration) and assign an IGSN (International Geo Sample Number) to each thin section. Additionally, the thin section records will be linked to the GSA's online record database. When complete, the GSA's thin sections will be more readily discoverable and have greater interoperability. Moving forward, the GSA is implementing use of NGDS-like content models and registration with SESAR and IGSN to improve collection maintenance and management of additional physical samples.

  5. 48 CFR 503.570-1 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Other Improper Business Practices 503.570-1 Policy. GSA policy precludes contractors from making references to GSA contracts in commercial advertising in...

  6. Growth stimulating antibody, as another predisposing factor of Graves' disease (GD): analysis using monoclonal TSH receptor antibodies derived from patients with GD.

    PubMed

    Ihara, Yoshiaki; Kanda, Yasunari; Seo, Marie; Watanabe, Yasuhiro; Akamizu, Takashi; Tanaka, Yuji

    2012-01-01

    TSH receptor antibody (TRAb) is clinically classified into thyroid stimulating antibody (TSAb) and thyroid-stimulation blocking antibody (TSBAb). Although the former is considered to cause Graves' disease (GD), its activity does not necessarily reflect hormone production and goiter size. Moreover, uptake of 99mTcO4(-), the best indicator for GD, is correlated with activity of TSH binding inhibitor immunoglobulin better than activity of TSAb. Because uptake of 99mTcO4(-) reflects thyroid volume, these observations suggest that there exist TRAb with thyrocyte growth stimulating activity (GSA) other than TSAb. In this study, we analyzed GSA of monoclonal TRAb established from patients with GD or idiopathic myxedema (IME). GSA was measured as the degree of FRTL-5 cell growth stimulated by each TRAb. The signaling pathways of the cell growth were pharmacologically analyzed. The cell growth stimulated by TSH was strongly suppressed by protein kinase A (PKA) inhibitor, but was not affected by extracellular signal regulated kinase kinase (MEK) inhibitor. Although TSAb from GD stimulated the cell growth, both inhibitors suppressed it. Surprisingly, the cell growth was also induced by TSBAb from GD and was only suppressed by MEK inhibitor. TSBAb from IME did not have GSA and attenuated the cell growth stimulated by TSH. We concluded that 1; in GD, not only TSAb but some TSBAb could stimulate thyrocyte growth. 2; TSBAb might be classified with respect to their effects on thyrocyte growth; i.e., thyrocyte growth stimulating antibody and thyrocyte growth-stimulation blocking antibody.

  7. Contextualizing Gay-Straight Alliances: Student, Advisor, and Structural Factors Related to Positive Youth Development Among Members

    PubMed Central

    Poteat, V. Paul; Yoshikawa, Hirokazu; Calzo, Jerel P.; Gray, Mary L.; DiGiovanni, Craig. D.; Lipkin, Arthur; Mundy-Shephard, Adrienne; Perrotti, Jeff; Scheer, Jillian R.; Shaw, Mathew P.

    2014-01-01

    Gay-Straight Alliances (GSAs) may promote resilience. Yet, what GSA components predict wellbeing? Among 146 youth and advisors in 13 GSAs (58% lesbian, gay, bisexual, or questioning; 64% white; 38% received free/reduced-cost lunch), student (demographics, victimization, attendance frequency, leadership, support, control), advisor (years served, training, control) and contextual factors (overall support or advocacy, outside support for the GSA) that predicted purpose, mastery, and self-esteem were tested. In multilevel models, GSA support predicted all outcomes. Racial/ethnic minority youth reported greater wellbeing, yet lower support. Youth in GSAs whose advisors served longer and perceived more control and were in more supportive school contexts reported healthier outcomes. GSA advocacy also predicted purpose. Ethnographic notes elucidated complex associations and variability in how GSAs operated. PMID:25176579

  8. 41 CFR 105-60.305-3 - GSA records available without charge.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General...-Availability of Opinions, Orders, Policies, Interpretations, Manuals, and Instructions § 105-60.305-3 GSA...

  9. 41 CFR 105-60.305-3 - GSA records available without charge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General...-Availability of Opinions, Orders, Policies, Interpretations, Manuals, and Instructions § 105-60.305-3 GSA...

  10. 32 CFR 644.391 - Predisposal conference.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... economy of the local community. For this purpose, installations, in many cases, will be reported to GSA... will be developed in conjunction with appropriate using command and GSA representatives. Its purpose...

  11. GSA committees: Progress through service the Annual Program Committee

    USGS Publications Warehouse

    Costa, J.E.

    2007-01-01

    The GSA's Annual Program Committee (APC) is directly responsible for the GSA's meeting and other responsibilities especially before the main event. It decides on the locations, the number and content of the technical sessions, annual membership surveys, hospitality for the guests, field trips and more. In addition, it pays significant attention to creative thinking about geoscience discoveries and directions as well as identify new and emerging areas of earth science. APC is also looking for new ideas, approaches and directions.

  12. 41 CFR 105-60.305-4 - GSA records available at a fee.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services..., Orders, Policies, Interpretations, Manuals, and Instructions § 105-60.305-4 GSA records available at a...

  13. 41 CFR 105-60.305-4 - GSA records available at a fee.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services..., Orders, Policies, Interpretations, Manuals, and Instructions § 105-60.305-4 GSA records available at a...

  14. Pathway-based analysis of GWAs data identifies association of sex determination genes with susceptibility to testicular germ cell tumors.

    PubMed

    Koster, Roelof; Mitra, Nandita; D'Andrea, Kurt; Vardhanabhuti, Saran; Chung, Charles C; Wang, Zhaoming; Loren Erickson, R; Vaughn, David J; Litchfield, Kevin; Rahman, Nazneen; Greene, Mark H; McGlynn, Katherine A; Turnbull, Clare; Chanock, Stephen J; Nathanson, Katherine L; Kanetsky, Peter A

    2014-11-15

    Genome-wide association (GWA) studies of testicular germ cell tumor (TGCT) have identified 18 susceptibility loci, some containing genes encoding proteins important in male germ cell development. Deletions of one of these genes, DMRT1, lead to male-to-female sex reversal and are associated with development of gonadoblastoma. To further explore genetic association with TGCT, we undertook a pathway-based analysis of SNP marker associations in the Penn GWAs (349 TGCT cases and 919 controls). We analyzed a custom-built sex determination gene set consisting of 32 genes using three different methods of pathway-based analysis. The sex determination gene set ranked highly compared with canonical gene sets, and it was associated with TGCT (FDRG = 2.28 × 10(-5), FDRM = 0.014 and FDRI = 0.008 for Gene Set Analysis-SNP (GSA-SNP), Meta-Analysis Gene Set Enrichment of Variant Associations (MAGENTA) and Improved Gene Set Enrichment Analysis for Genome-wide Association Study (i-GSEA4GWAS) analysis, respectively). The association remained after removal of DMRT1 from the gene set (FDRG = 0.0002, FDRM = 0.055 and FDRI = 0.009). Using data from the NCI GWA scan (582 TGCT cases and 1056 controls) and UK scan (986 TGCT cases and 4946 controls), we replicated these findings (NCI: FDRG = 0.006, FDRM = 0.014, FDRI = 0.033, and UK: FDRG = 1.04 × 10(-6), FDRM = 0.016, FDRI = 0.025). After removal of DMRT1 from the gene set, the sex determination gene set remains associated with TGCT in the NCI (FDRG = 0.039, FDRM = 0.050 and FDRI = 0.055) and UK scans (FDRG = 3.00 × 10(-5), FDRM = 0.056 and FDRI = 0.044). With the exception of DMRT1, genes in the sex determination gene set have not previously been identified as TGCT susceptibility loci in these GWA scans, demonstrating the complementary nature of a pathway-based approach for genome-wide analysis of TGCT. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  15. 41 CFR 105-64.108 - How does GSA safeguard personal information?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.108 How does...

  16. 41 CFR 105-64.109 - How does GSA handle other agencies' records?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.109 How does...

  17. 41 CFR 105-64.109 - How does GSA handle other agencies' records?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.109 How does...

  18. NPDES Permit for General Services Administration (GSA) West Heating Plant

    EPA Pesticide Factsheets

    Under National Pollutant Discharge Elimination System permit number DC0000035, General Services Administration (GSA) West Heating Plant is authorized to discharge from a facility to receiving waters named Rock Creek.

  19. 48 CFR 8.703 - Procurement list.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Administration (GSA) Supply Catalog and GSA's Customer Service Center Catalogs with a black square and the words “NIB/NISH Mandatory Source,” and in similar catalogs issued by the Defense Logistics Agency (DLA) and...

  20. 48 CFR 8.703 - Procurement list.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Administration (GSA) Supply Catalog and GSA's Customer Service Center Catalogs with a black square and the words “NIB/NISH Mandatory Source,” and in similar catalogs issued by the Defense Logistics Agency (DLA) and...

  1. 41 CFR 102-192.100 - How do we submit our annual mail management report to GSA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION... annual reports using the GSA web-based Electronic Performance Support Tool (EPST). Agency mail managers...

  2. 32 CFR 644.391 - Predisposal conference.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... that the Report of Excess to GSA specifically identifies and excludes the real and personal property to... GSA will be summarized in the report, along with any other problems encountered or foreseen. (d) When...

  3. 77 FR 40883 - General Services Administration Acquisition Regulation; Submission for OMB Review; Identification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... CONTACT: Ms. Dana Munson, Procurement Analyst, General Services Acquisition Policy Division, GSA, at...) requires contractors submitting Multiple Award Schedule Contracts to identify in their GSA price lists...

  4. 76 FR 38179 - General Services Administration Acquisition Regulation; Information Collection; GSAR Provision...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... CONTACT: Mr. Michael Jackson, Procurement Analyst, Contract Policy Division, GSA, (202) 208-4949 or michaelo.jackson@gsa.gov . ADDRESSES: Submit comments identified by Information Collection 3090- 0197, GSAR...

  5. 75 FR 27344 - Submission for OMB Review; Notification of Ownership Changes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... INFORMATION CONTACT: Michael O. Jackson, Procurement Analyst, Contract Policy Branch, GSA, (202) 208-4949 or e-mail michaelo.jackson@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose Allowable costs of assets are...

  6. 75 FR 9603 - Federal Acquisition Regulation; Information Collection; Notification of Ownership Changes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ... 4041, Washington, DC 20405. FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Contract Policy Branch, GSA, (202) 208-4949 or e-mail michaelo.jackson@gsa.gov . SUPPLEMENTARY...

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pal, Pinaki; Probst, Daniel; Pei, Yuanjiang

    Fuels in the gasoline auto-ignition range (Research Octane Number (RON) > 60) have been demonstrated to be effective alternatives to diesel fuel in compression ignition engines. Such fuels allow more time for mixing with oxygen before combustion starts, owing to longer ignition delay. Moreover, by controlling fuel injection timing, it can be ensured that the in-cylinder mixture is “premixed enough” before combustion occurs to prevent soot formation while remaining “sufficiently inhomogeneous” in order to avoid excessive heat release rates. Gasoline compression ignition (GCI) has the potential to offer diesel-like efficiency at a lower cost and can be achieved with fuelsmore » such as low-octane straight run gasoline which require significantly less processing in the refinery compared to today’s fuels. To aid the design and optimization of a compression ignition (CI) combustion system using such fuels, a global sensitivity analysis (GSA) was conducted to understand the relative influence of various design parameters on efficiency, emissions and heat release rate. The design parameters included injection strategies, exhaust gas recirculation (EGR) fraction, temperature and pressure at intake valve closure and injector configuration. These were varied simultaneously to achieve various targets of ignition timing, combustion phasing, overall burn duration, emissions, fuel consumption, peak cylinder pressure and maximum pressure rise rate. The baseline case was a three-dimensional closed-cycle computational fluid dynamics (CFD) simulation with a sector mesh at medium load conditions. Eleven design parameters were considered and ranges of variation were prescribed to each of these. These input variables were perturbed in their respective ranges using the Monte Carlo (MC) method to generate a set of 256 CFD simulations and the targets were calculated from the simulation results. GSA was then applied as a screening tool to identify the input parameters having the most significant impact on each target. The results were further assessed by investigating the impact of individual parameter variations on the targets. Overall, it was demonstrated that GSA can be an effective tool in understanding parameters sensitive to a low temperature combustion concept with novel fuels.« less

  8. ACHP | News | ACHP Considers Program Comment for Select GSA Repairs and

    Science.gov Websites

    ) legislation has provided GSA with significant stewardship opportunities for its historic public buildings . However, the rigid spending deadline associated with the legislation has prompted the need for this

  9. 41 CFR 101-26.310 - Ordering errors.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... Exceptions may be granted on a case-by-case basis when GSA is in need of the material and extenuating.... However, when the condition is attributable to carrier negligence, subsequent credit allowed by GSA will...

  10. 41 CFR 101-26.506-1 - Types of service.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROGRAM 26.5-GSA Procurement Programs § 101-26.506-1 Types of service. GSA interior planning and design...; softline space plans; development of an interior design program (to include finish materials, furniture and...

  11. 75 FR 69988 - Privacy Act of 1974; Computer Matching Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... Administration (GSA) for inclusion in GSA's List of Parties Excluded from Federal Procurements and Nonprocurement... (FRS), toll free, at 1-800-877-8339. Individuals with disabilities can obtain this document in an...

  12. 41 CFR 102-36.210 - Why must we report excess personal property to GSA?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... paid for with taxpayers' money, thus minimizing new procurement costs. Reporting excess personal property to GSA helps assure that the information on available excess personal property is accessible and...

  13. 41 CFR 102-36.210 - Why must we report excess personal property to GSA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... paid for with taxpayers' money, thus minimizing new procurement costs. Reporting excess personal property to GSA helps assure that the information on available excess personal property is accessible and...

  14. 41 CFR 102-36.210 - Why must we report excess personal property to GSA?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... paid for with taxpayers' money, thus minimizing new procurement costs. Reporting excess personal property to GSA helps assure that the information on available excess personal property is accessible and...

  15. 41 CFR 102-36.210 - Why must we report excess personal property to GSA?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... paid for with taxpayers' money, thus minimizing new procurement costs. Reporting excess personal property to GSA helps assure that the information on available excess personal property is accessible and...

  16. 41 CFR 102-36.210 - Why must we report excess personal property to GSA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... paid for with taxpayers' money, thus minimizing new procurement costs. Reporting excess personal property to GSA helps assure that the information on available excess personal property is accessible and...

  17. 76 FR 35219 - Federal Acquisition Regulation; Information Collection; Payment by Electronic Fund Transfer

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-16

    ... Chambers, Procurement Analyst, Acquisition Policy Division, GSA (202) 501-3221, or Edward.chambers@gsa.gov...: June 7, 2011. Millisa Gary, Acting Director, Office of Governmentwide Acquisition Policy. [FR Doc. 2011...

  18. Evaluation of the econo-mist device

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The Emission Control Technology Division (ECTD) was contacted by the General Services Administration (GSA) concerning a vapor injection device for use with automobile engines. The device is called the Econo-Mist and is a product of the FAP Corporation of Albuquerque, New Mexico. GSA had received information that the Econo-Mist reduced hydrocarbon and carbon monoxide emissions and increased fuel economy. At the request of GSA, ECTD agreed to test the device. A sample of the device was brought to the EPA laboratory in Ann Arbor, Michigan by FAP Corporation personnel on January 13, 1975.

  19. Reducing Costs and Increasing Productivity in Ship Maintenance Using Product Lifecycle Management, 3D Laser Scanning and 3D Printing

    DTIC Science & Technology

    2014-03-01

    information modeling guide series: 03—GSA BIM guide for 3D imaging (Ver. 1). Retrieved from http://www.gsa.gov/graphics/pbs/GSA_BIM_Guide_Series_03... model during a KVA knowledge audit at FRC San Diego. The information used in the creation of his KVA models was generated from the SME-provided...Kenney then used the information gathered during SME interviews to reengineer the process to include 3D printing to form his “to-be” model . The

  20. Fractal Dimension of Tc-99m DTPA GSA Estimates Pathologic Liver Injury due to Chemotherapy in Liver Cancer Patients.

    PubMed

    Hiroshima, Yukihiko; Shuto, Kiyohiko; Yamazaki, Kazuto; Kawaguchi, Daisuke; Yamada, Masatoshi; Kikuchi, Yutaro; Kasahara, Kohei; Murakami, Takashi; Hirano, Atsushi; Mori, Mikito; Kosugi, Chihiro; Matsuo, Kenichi; Ishida, Yasuo; Koda, Keiji; Tanaka, Kuniya

    2016-12-01

    Chemotherapy-induced liver injury after potent chemotherapy is a considerable problem in patients undergoing liver resection. The aim of this study was to assess the relationship between the fractal dimension (FD) of Tc-99m diethylenetriaminepentaacetic acid (DTPA) galactosyl human serum albumin (GSA) and pathologic change of liver parenchyma in liver cancer patients who have undergone chemotherapy. We examined 34 patients (10 female and 24 male; mean age, 68.5 years) who underwent hepatectomy. Hepatic injury was defined as steatosis more than 30 %, grade 2-3 sinusoidal dilation, and/or steatohepatitis Kleiner score ≥4. Fractal analysis was applied to all images of Tc-99m DTPA GSA using a plug-in tool on ImageJ software (NIH, Bethesda, MD). A differential box-counting method was applied, and FD was calculated as a heterogeneity parameter. Correlations between FD and clinicopathological variables were examined. FD values of patients with steatosis and steatohepatitis were significantly higher than those without (P > .001 and P > .001, respectively). There was no difference between the FD values of patients with and without sinusoidal dilatation (P = .357). Multivariate logistic regression showed FD as the only significant predictor for steatosis (P = .005; OR 36.5; 95 % CI 3.0-446.3) and steatohepatitis (P = .012; OR, 29.1; 95 % CI 2.1-400.1). FD of Tc-99m DTPA GSA was the significant predictor for fatty liver disease in patients who underwent chemotherapy. This new modality is able to differentiate steatohepatitis from steatosis; therefore, it may be useful for predicting chemotherapy-induced pathologic liver injury.

  1. Predictive Uncertainty And Parameter Sensitivity Of A Sediment-Flux Model: Nitrogen Flux and Sediment Oxygen Demand

    EPA Science Inventory

    Estimating model predictive uncertainty is imperative to informed environmental decision making and management of water resources. This paper applies the Generalized Sensitivity Analysis (GSA) to examine parameter sensitivity and the Generalized Likelihood Uncertainty Estimation...

  2. 41 CFR 101-26.503 - Multiple award schedule purchases made by GSA supply distribution facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... facilities are responsible for quickly and economically providing customers with frequently needed common-use... is an important way in which GSA supply distribution facilities meet this responsibility. [60 FR...

  3. Evaluation of habitat suitability index models by global sensitivity and uncertainty analyses: a case study for submerged aquatic vegetation

    USGS Publications Warehouse

    Zajac, Zuzanna; Stith, Bradley M.; Bowling, Andrea C.; Langtimm, Catherine A.; Swain, Eric D.

    2015-01-01

    Habitat suitability index (HSI) models are commonly used to predict habitat quality and species distributions and are used to develop biological surveys, assess reserve and management priorities, and anticipate possible change under different management or climate change scenarios. Important management decisions may be based on model results, often without a clear understanding of the level of uncertainty associated with model outputs. We present an integrated methodology to assess the propagation of uncertainty from both inputs and structure of the HSI models on model outputs (uncertainty analysis: UA) and relative importance of uncertain model inputs and their interactions on the model output uncertainty (global sensitivity analysis: GSA). We illustrate the GSA/UA framework using simulated hydrology input data from a hydrodynamic model representing sea level changes and HSI models for two species of submerged aquatic vegetation (SAV) in southwest Everglades National Park: Vallisneria americana (tape grass) and Halodule wrightii (shoal grass). We found considerable spatial variation in uncertainty for both species, but distributions of HSI scores still allowed discrimination of sites with good versus poor conditions. Ranking of input parameter sensitivities also varied spatially for both species, with high habitat quality sites showing higher sensitivity to different parameters than low-quality sites. HSI models may be especially useful when species distribution data are unavailable, providing means of exploiting widely available environmental datasets to model past, current, and future habitat conditions. The GSA/UA approach provides a general method for better understanding HSI model dynamics, the spatial and temporal variation in uncertainties, and the parameters that contribute most to model uncertainty. Including an uncertainty and sensitivity analysis in modeling efforts as part of the decision-making framework will result in better-informed, more robust decisions.

  4. Novel Index (Hepatic Receptor: IHR) to Evaluate Hepatic Functional Reserve Using (99m)Tc-GSA Scintigraphy.

    PubMed

    Hasegawa, Daisuke; Onishi, Hideo; Matsutomo, Norikazu

    2016-02-01

    This study aimed to evaluate the novel index of hepatic receptor (IHR) on the regression analysis derived from time activity curve of the liver for hepatic functional reserve. Sixty patients had undergone (99m)Tc-galactosyl serum albumin ((99m)Tc-GSA) scintigraphy in the retrospective clinical study. Time activity curves for liver were obtained by region of interest (ROI) on the whole liver. A novel hepatic functional predictor was calculated with multiple regression analysis of time activity curves. In the multiple regression function, the objective variables were the indocyanine green (ICG) retention rate at 15 min, and the explanatory variables were the liver counts in 3-min intervals until end from beginning. Then, this result was defined by IHR, and we analyzed the correlation between IHR and ICG, uptake ratio of the heart at 15 minutes to that at 3 minutes (HH15), uptake ratio of the liver to the liver plus heart at 15 minutes (LHL15), and index of convexity (IOC). Regression function of IHR was derived as follows: IHR=0.025×L(6)-0.052×L(12)+0.027×L(27). The multiple regression analysis indicated that liver counts at 6 min, 12 min, and 27 min were significantly related to objective variables. The correlation coefficient between IHR and ICG was 0.774, and the correlation coefficient between ICG and conventional indices (HH15, LHL15, and IOC) were 0.837, 0.773, and 0.793, respectively. IHR had good correlation with HH15, LHL15, and IOC. The finding results suggested that IHR would provide clinical benefit for hepatic functional assessment in the (99m)Tc-GSA scintigraphy.

  5. Measuring hepatic functional reserve using low temporal resolution Gd-EOB-DTPA dynamic contrast-enhanced MRI: a preliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention.

    PubMed

    Saito, Kazuhiro; Ledsam, Joseph; Sourbron, Steven; Hashimoto, Tsuyoshi; Araki, Yoichi; Akata, Soichi; Tokuuye, Koichi

    2014-01-01

    To investigate if tracer kinetic modelling of low temporal resolution dynamic contrast-enhanced (DCE) MRI with Gd-EOB-DTPA could replace technetium-99 m galactosyl human serum albumin (GSA) single positron emission computed tomography (SPECT) and indocyanine green (ICG) retention for the measurement of liver functional reserve. Twenty eight patients awaiting liver resection for various cancers were included in this retrospective study that was approved by the institutional review board. The Gd-EOB-DTPA MRI sequence acquired five images: unenhanced, double arterial phase, portal phase, and 4 min after injection. Intracellular contrast uptake rate (UR) and extracellular volume (Ve) were calculated from DCE-MRI, along with the ratio of GSA radioactivity of liver to heart-plus-liver and per cent of cumulative uptake from 15-16 min (LHL15 and LU15, respectively) from GSA-scintigraphy. ICG retention at 15 min, Child-Pugh cirrhosis score (CPS) and postoperative Inuyama fibrosis criteria were also recorded. Statistical analysis was with Spearman rank correlation analysis. Comparing MRI parameters with the reference methods, significant correlations were obtained for UR and LHL15, LU15, ICG15 (all 0.4-0.6, P < 0.05); UR and CPS (-0.64, P < 0.001); Ve and Inuyama (0.44, P < 0.05). Measures of liver function obtained by routine Gd-EOB-DTPA DCE-MRI with tracer kinetic modelling may provide a suitable method for the evaluation of liver functional reserve. • Magnetic resonance imaging (MRI) provides new methods of measuring hepatic functional reserve. • DCE-MRI with Gd-EOB-DTPA offers the possibility of replacing scintigraphy. • The analysis method can be used for preoperative liver function evaluation.

  6. Metamodeling as a tool to size vegetative filter strips for surface runoff pollution control in European watersheds.

    NASA Astrophysics Data System (ADS)

    Lauvernet, Claire; Muñoz-Carpena, Rafael; Carluer, Nadia

    2015-04-01

    In Europe, a significant presence of contaminants is found in surface water, partly due to pesticide applications. Vegetative filter strips or buffer zones (VFS), often located along rivers, are a common best management practice (BMP) to reduce non point source pollution of water by reducing surface runoff. However, they need to be adapted to the agro-ecological and climatic conditions, both in terms of position and size, in order to be efficient. The TOPPS-PROWADIS project involves European experts and stakeholders to develop and recommend BMPs to reduce pesticide transfer by drift or runoff in several European countries. In this context, IRSTEA developed a guide accompanying the use of different tools, which allows designing site-specific VFS by simulating their efficiency to limit transfers using the mechanistic model VFSMOD. This method which is very complete assumes that the user provides detailed field knowledge and data, which are not always easily available. The aim of this study is to assist the buffer sizing by using a unique tool with a reduced set of parameters, adapted to the available information from the end-users. In order to fill in the lack of real data in many practical applications, a set of virtual scenarios was selected to encompass a large range of agro-pedo-climatic conditions in Europe, considering both the upslope agricultural field and the VFS characteristics. As a first step first, in this work we present scenarios based on North-West of France climate consisting of different rainfall intensities and durations, hillslope lengths and slopes, humidity conditions, a large set of field rainfall/runoff characteristics for the contributing area, and several shallow water table depths and soil types for the VFS. The sizing method based on the mechanistic model VFSMOD was applied for all these scenarios, and a global sensitivity analysis (GSA) of the VFS optimal length was performed for all the input parameters in order to understand their influence and interactions, and set priorities for data collecting and management. Based on GSA results, we compared several mathematical methods to compute the metamodel, and then validated it on an agricultural watershed with real data in the North-West of France. The analysis procedure allows for a robust and validated metamodel, before extending it on other climatic conditions in order to make the application on a large range of european watersheds possible. The tool will allow comparison of field scenarios, and to validate/improve actual existing placements and VFS sizing.

  7. 48 CFR 908.7101-2 - Consolidated acquisition of new vehicles by General Services Administration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... GSA's online vehicle purchasing system (AutoChoice). (b) Orders for all motor vehicles shall be submitted utilizing GSA's on-line system (Auto Choice), in accordance with FPMR 41 CFR 101-26.501...

  8. 48 CFR 908.7101-2 - Consolidated acquisition of new vehicles by General Services Administration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... GSA's online vehicle purchasing system (AutoChoice). (b) Orders for all motor vehicles shall be submitted utilizing GSA's on-line system (Auto Choice), in accordance with FPMR 41 CFR 101-26.501...

  9. 48 CFR 532.7002 - Solicitation requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... Identify the card brand(s) under the GSA SmartPay program that may be used to make payments under the... the card brand(s) under the GSA SmartPay program that may be used to make payments under the contract...

  10. 41 CFR 301-72.301 - How do we process unused, partially used, and exchanged tickets?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (http://fss.gsa.gov/transtrav/usgpth.pdf) for policies and procedures regarding the use of SF 1170. (b... the U.S. Government Passenger Transportation Handbook (http://fss.gsa.gov/transtrav/usgpth.pdf). [FTR...

  11. 41 CFR 102-33.275 - Are there restrictions on replacing aircraft by exchange or sale?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...). In your letter of request to GSA, you must include the full details of your situation and the... request and justify a waiver from GSA, Aircraft Management Policy Division (MTA), 1800 F Street, NW...

  12. 41 CFR 101-39.003 - Financing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET..., and operation of fleet management systems. (b) When an agency other than GSA operates an interagency fleet management system, the financing and accounting methods shall be developed by GSA in cooperation...

  13. 75 FR 1788 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1364...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... being offered for lease to house Federal agencies. In the past, GSA also used a 1364A which requested..., offerors' design and construction fees). A request for public comments was published in the Federal...

  14. 41 CFR 102-192.100 - How do we submit our annual mail management report to GSA?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.100 How do we submit our annual mail... annual reports using the GSA web-based Electronic Performance Support Tool (EPST). Agency mail managers...

  15. 41 CFR 102-192.100 - How do we submit our annual mail management report to GSA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.100 How do we submit our annual mail... annual reports using the GSA web-based Electronic Performance Support Tool (EPST). Agency mail managers...

  16. 41 CFR 102-192.100 - How do we submit our annual mail management report to GSA?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.100 How do we submit our annual mail... annual reports using the GSA web-based Electronic Performance Support Tool (EPST). Agency mail managers...

  17. 41 CFR 102-192.100 - How do we submit our annual mail management report to GSA?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Reporting Requirements § 102-192.100 How do we submit our annual mail... annual reports using the GSA web-based Electronic Performance Support Tool (EPST). Agency mail managers...

  18. 19. INTERIOR, 'CHILLER NO. 2' (G.S.A. PHOTOCOPY, N.D.) (4 x ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. INTERIOR, 'CHILLER NO. 2' (G.S.A. PHOTOCOPY, N.D.) (4 x 5 NEGATIVE) - U.S. General Services Administration, Central Heating Plant, C & D Streets between Twelfth & Thirteenth Streets Southwest, Washington, District of Columbia, DC

  19. 75 FR 51392 - Federal Management Regulation; Transportation Management

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ...; Docket Number 2010-0011, sequence 1] RIN 3090-AJ03 Federal Management Regulation; Transportation Management AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Final rule. SUMMARY: The General Services Administration (GSA) is amending the Federal Management Regulation (FMR) by...

  20. Re-Assessing Green Building Performance: A Post Occupancy Evaluation of 22 GSA Buildings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fowler, Kimberly M.; Rauch, Emily M.; Henderson, Jordan W.

    2010-06-01

    2nd report on the performance of GSA's sustainably designed buildings. The purpose of this study was to provide an overview of measured whole building performance as it compares to GSA and industry baselines. The PNNL research team found the data analysis illuminated strengths and weaknesses of individual buildings as well as the portfolio of buildings. This section includes summary data, observations that cross multiple performance metrics, discussion of lessons learned from this research, and opportunities for future research. The summary of annual data for each of the performance metrics is provided in Table 25. The data represent 1 year ofmore » measurements and are not associated with any specific design features or strategies. Where available, multiple years of data were examined and there were minimal significant differences between the years. Individually focused post occupancy evaluation (POEs) would allow for more detailed analysis of the buildings. Examining building performance over multiple years could potentially offer a useful diagnostic tool for identifying building operations that are in need of operational changes. Investigating what the connection is between the building performance and the design intent would offer potential design guidance and possible insight into building operation strategies. The 'aggregate operating cost' metric used in this study represents the costs that were available for developing a comparative industry baseline for office buildings. The costs include water utilities, energy utilities, general maintenance, grounds maintenance, waste and recycling, and janitorial costs. Three of the buildings that cost more than the baseline in Figure 45 have higher maintenance costs than the baseline, and one has higher energy costs. Given the volume of data collected and analyzed for this study, the inevitable request is for a simple answer with respect to sustainably designed building performance. As previously stated, compiling the individual building values into single metrics is not statistically valid given the small number of buildings, but it has been done to provide a cursory view of this portfolio of sustainably designed buildings. For all metrics except recycling cost per rentable square foot and CBE survey response rate, the averaged building performance was better than the baseline for the GSA buildings in this study.« less

  1. 41 CFR 105-60.403 - Appeal within GSA.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Appeal within GSA. 105-60.403 Section 105-60.403 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...

  2. 41 CFR 105-60.403 - Appeal within GSA.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Appeal within GSA. 105-60.403 Section 105-60.403 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...

  3. 41 CFR 105-60.403 - Appeal within GSA.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Appeal within GSA. 105-60.403 Section 105-60.403 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...

  4. 41 CFR 105-60.403 - Appeal within GSA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Appeal within GSA. 105-60.403 Section 105-60.403 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...

  5. 41 CFR 101-39.300 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System Vehicles § 101-39.300 General. (a) The objective of the General Services Administration (GSA) Interagency Fleet Management System...

  6. 41 CFR 101-39.302 - Rotation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System Vehicles § 101-39.302 Rotation. GSA Interagency Fleet Management System (IFMS) vehicles on high mileage assignments may be...

  7. 75 FR 4822 - 2010 Travel and Relocation Excellence Award

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... GENERAL SERVICES ADMINISTRATION 2010 Travel and Relocation Excellence Award AGENCY: Office of... Administration (GSA) is seeking candidates for the biennial 2010 Travel and Relocation Excellence Award, which honors excellence in federal travel and relocation policy. FOR FURTHER INFORMATION CONTACT: Go to GSA's...

  8. 48 CFR 7.403 - General Services Administration assistance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...; and (4) Industry or market trends. (b) Agencies may request information from the following GSA offices: (1) Center for Strategic IT Analysis (MKS), Washington, DC 20405, for information on acquisition of... in lease or purchase decisions by providing information such as— (1) Pending price adjustments to...

  9. First experiment on retrieval of tropospheric NO2 over polluted areas with 2.4-km spatial resolution basing on satellite spectral measurements

    NASA Astrophysics Data System (ADS)

    Postylyakov, Oleg V.; Borovski, Alexander N.; Makarenkov, Aleksandr A.

    2017-11-01

    Three satellites of the Resurs-P series (№1, №2, №3) aimed for remote sensing of the Earth began to operate in Russia in 2013-2016. Hyperspectral instruments GSA onboard Resurs-P perform routine imaging of the Earth surface in the spectral range of 400-1000 nm with the spectral resolution better than 10 nm and the spatial resolution of 30 m. In a special regime the GSA/Resurs-P may reach higher spectral resolution with the spatial resolution of 120 m and be used for retrieval of the tropospheric NO2 spatial distribution. We developed the first GSA/Resurs-P algorithm for the tropospheric NO2 retrieval and shortly analyze the first results for the most polluted Hebei province of China. The developed GSA/Resurs-P algorithm shows the spatial resolution of about 2.4 km for tropospheric NO2 pollution what significantly exceed resolution of other available now satellite instruments and considered as a target for future geostationary (GEO) missions for monitoring of tropospheric NO2 pollution. Differ to the currently operated low-Earth orbit (LEO) instruments, which may provide global distribution of NO2 every one or two days, GSA performs NO2 measurement on request. The precision of the NO2 measurements with 2.4 km resolution is about 2.5x1015 mol/cm2 (for DSCD) therefore it is recommended to use it for investigation of the tropospheric NO2 in polluted areas. Thus GSA/Resurs-P is the interesting and unique tool for NO2 pollution investigations and testing methods of interpretation of future high-resolution satellite data on pollutions and their emissions.

  10. Global sensitivity analysis of the BSM2 dynamic influent disturbance scenario generator.

    PubMed

    Flores-Alsina, Xavier; Gernaey, Krist V; Jeppsson, Ulf

    2012-01-01

    This paper presents the results of a global sensitivity analysis (GSA) of a phenomenological model that generates dynamic wastewater treatment plant (WWTP) influent disturbance scenarios. This influent model is part of the Benchmark Simulation Model (BSM) family and creates realistic dry/wet weather files describing diurnal, weekend and seasonal variations through the combination of different generic model blocks, i.e. households, industry, rainfall and infiltration. The GSA is carried out by combining Monte Carlo simulations and standardized regression coefficients (SRC). Cluster analysis is then applied, classifying the influence of the model parameters into strong, medium and weak. The results show that the method is able to decompose the variance of the model predictions (R(2)> 0.9) satisfactorily, thus identifying the model parameters with strongest impact on several flow rate descriptors calculated at different time resolutions. Catchment size (PE) and the production of wastewater per person equivalent (QperPE) are two parameters that strongly influence the yearly average dry weather flow rate and its variability. Wet weather conditions are mainly affected by three parameters: (1) the probability of occurrence of a rain event (Llrain); (2) the catchment size, incorporated in the model as a parameter representing the conversion from mm rain · day(-1) to m(3) · day(-1) (Qpermm); and, (3) the quantity of rain falling on permeable areas (aH). The case study also shows that in both dry and wet weather conditions the SRC ranking changes when the time scale of the analysis is modified, thus demonstrating the potential to identify the effect of the model parameters on the fast/medium/slow dynamics of the flow rate. The paper ends with a discussion on the interpretation of GSA results and of the advantages of using synthetic dynamic flow rate data for WWTP influent scenario generation. This section also includes general suggestions on how to use the proposed methodology to any influent generator to adapt the created time series to a modeller's demands.

  11. 75 FR 14442 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ..., Appendices A through D. The tables are instead published at http://www.gsa.gov/relocationpolicy . FTR Bulletin 10-04 is attached. FTR Bulletin 10-04 and all other FTR Bulletins may be found at http://www.gsa...

  12. 41 CFR 102-2.125 - What source of information can my agency use to identify materials that describe how to do...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... information on how to do business with GSA. References include customer service guides, handbooks, brochures... for the acquisition of GSA services. However, as a service to users during the transition from the...

  13. 41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

  14. 41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

  15. 41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

  16. 41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

  17. 41 CFR 302-4.300 - What is the POV mileage rate for PCS travel?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... www.irs.gov. GSA publishes the rate for mileage reimbursement in an FTR Bulletin on an intermittent basis. You may find the FTR Bulletins at www.gsa.gov/relo. [FTR Amdt. 2007-06, 72 FR 70235, Dec. 11...

  18. 76 FR 4112 - Federal Acquisition Regulation; Submission for OMB Review; Contract Financing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-24

    ... INFORMATION CONTACT: Mr. Edward Chambers, Procurement Analyst, Contract Policy Branch, GSA, (202) 501-4770 or e-mail Edward.chambers@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose The Federal Acquisition... all correspondence. Dated: January 13, 2011. Millisa Gary, Acting Director, Office of Governmentwide...

  19. 41 CFR 101-26.305 - Submission of orders to GSA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Submission of orders to GSA. 101-26.305 Section 101-26.305 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT...

  20. 48 CFR 945.570-1 - Acquisition of motor vehicles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... vehicles. 945.570-1 Section 945.570-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT... vehicles. (a) GSA Interagency Fleet Management System (GSA-IFMS) is the first source of supply for providing motor vehicles to contractors; however, contracting officer approval is required for contractors...

  1. 48 CFR 945.570-2 - Acquisition of motor vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... vehicles. 945.570-2 Section 945.570-2 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT... Acquisition of motor vehicles. (a) The GSA Interagency Fleet Management System (GSA-IFMS) is the first source of supply for providing motor vehicles to contractors; however, contracting officer approval is...

  2. Consumables: Are Servmarts Cost Effective?

    DTIC Science & Technology

    1995-09-01

    direct purchases of paper products and cleaning supplies from the GSA depot in Stockton were found to be cheaper than buying from the SERVMART. In...to use a combination of GSA Stockton for paper products and cleaning supplies and local vendors for rest of their non-military consumable item needs.

  3. 76 FR 5375 - Public Availability of General Services Administration FY 2010 Service Contract Inventory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... GENERAL SERVICES ADMINISTRATION [2011-MV-1; Docket No. 2011-0006; Sequence 4] Public Availability of General Services Administration FY 2010 Service Contract Inventory AGENCY: Office of Acquisition Policy; General Services Administration (GSA). ACTION: Notice. SUMMARY: This notice announces that GSA is...

  4. Program Manager - A Bimonthly Magazine of DSMC, Volume 27, Number 2.

    DTIC Science & Technology

    1998-04-01

    catalog. http /www.gsa.gov -------------- - Online shopping for commercial items to http ’Iwww.ndia.org I--- support government interests. Events...funds. Allows users access to GAO "Whats New in Contracting?" educational reports, FAQs. products catalog. http://www.gsa.gov Online shopping for

  5. 41 CFR 105-64.108 - How does GSA safeguard personal information?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How does GSA safeguard personal information? 105-64.108 Section 105-64.108 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General...

  6. 48 CFR 945.570-2 - Acquisition of motor vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Acquisition of motor... Acquisition of motor vehicles. (a) The GSA Interagency Fleet Management System (GSA-IFMS) is the first source of supply for providing motor vehicles to contractors; however, contracting officer approval is...

  7. 48 CFR 945.570-2 - Acquisition of motor vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition of motor... Acquisition of motor vehicles. (a) The GSA Interagency Fleet Management System (GSA-IFMS) is the first source of supply for providing motor vehicles to contractors; however, contracting officer approval is...

  8. 78 FR 67180 - Federal Property Suitable as Facilities To Assist the Homeless

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Navy, Asset Management Division, Naval Facilities Engineering Command, Washington Navy Yard, 1330...: Landholding Agency- US Forest Service Disposal Agency- GSA Comments: 53.6 acres; agricultural/research...- GSA Comments: 54.8 acres; agricultural/research; Sec. 106 Nat'l Historic review required to transfer...

  9. 41 CFR 109-39.101-1 - Agency cooperation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.101-1 Agency cooperation. The Director, Office of... representatives to coordinate with GSA concerning the establishment of a GSA fleet management system to serve...

  10. 41 CFR 101-39.201 - Services available.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services § 101-39.201 Services available. GSA Interagency Fleet Management System (IFMS) vehicles and services shall be used in... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Services available. 101...

  11. 76 FR 63844 - Federal Travel Regulation (FTR); Lodging Reimbursement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ...; Docket Number 2011-0024, Sequence 1] RIN 3090-AJ22 Federal Travel Regulation (FTR); Lodging Reimbursement... (GSA) is amending the Federal Travel Regulation (FTR) regarding reimbursement of lodging per diem expenses while on temporary duty travel (TDY). This final rule specifically states GSA's policy in regards...

  12. 41 CFR 102-192.170 - What are GSA's responsibilities in mail management?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are GSA's responsibilities in mail management? 102-192.170 Section 102-192.170 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION ADMINISTRATIVE...

  13. ENVIRONMENTAL ASSESSMENT OF A WASTE-TO-ENERGY PROCESS: GSA/PENTAGON CO-FIRED BOILER TESTS

    EPA Science Inventory

    Midwest Research Institute (MRI), in conjuction with the General Services Administration (GSA) and the National Center for Resource Recovery (NCRR), conducted a series of emission tests at the Virginia Heating and Refrigeration Plant (VHRP) in Arlington, Virginia (this plant prov...

  14. 78 FR 23542 - Procurement List Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ...: Federal Acquisition Service, GSA/FSS OFC SUP CTR--Paper Products, New York, NY Coverage: A-List for the..., NY Contracting Activity: Federal Acquisition Service, GSA/FSS OFC SUP CTR--Paper Products, New York... Procurement List. SUMMARY: This action adds products and services to the Procurement List that will be...

  15. 41 CFR 101-30.303 - Responsibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... cataloging and data preparation and transmission capabilities, when authorized by GSA, shall submit data... activity; i.e., GSA or VA, for the performance of all cataloging functions and/or the preparation of data... Defense Integrated Data System (DIDS) Procedures Manual (DOD 4100.39-M). (b) Agencies not having the...

  16. 41 CFR 101-30.303 - Responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... cataloging and data preparation and transmission capabilities, when authorized by GSA, shall submit data... activity; i.e., GSA or VA, for the performance of all cataloging functions and/or the preparation of data... Defense Integrated Data System (DIDS) Procedures Manual (DOD 4100.39-M). (b) Agencies not having the...

  17. Agile Data Curation at a State Geological Survey

    NASA Astrophysics Data System (ADS)

    Hills, D. J.

    2015-12-01

    State agencies, including geological surveys, are often the gatekeepers for myriad data products essential for scientific research and economic development. For example, the Geological Survey of Alabama (GSA) is mandated to explore for, characterize, and report Alabama's mineral, energy, water, and biological resources in support of economic development, conservation, management, and public policy for the betterment of Alabama's citizens, communities, and businesses. As part of that mandate, the GSA has increasingly been called upon to make our data more accessible to stakeholders. Even as demand for greater data accessibility grows, budgets for such efforts are often small, meaning that agencies must do more for less. Agile software development has yielded efficient, effective products, most often at lower cost and in shorter time. Taking guidance from the agile software development model, the GSA is working towards more agile data management and curation. To date, the GSA's work has been focused primarily on data rescue. By using workflows that maximize clear communication while encouraging simplicity (e.g., maximizing the amount of work not done or that can be automated), the GSA is bringing decades of dark data into the light. Regular checks by the data rescuer with the data provider (or their proxy) provides quality control without adding an overt burden on either party. Moving forward, these workflows will also allow for more efficient and effective data management.

  18. Comparison of Two Global Sensitivity Analysis Methods for Hydrologic Modeling over the Columbia River Basin

    NASA Astrophysics Data System (ADS)

    Hameed, M.; Demirel, M. C.; Moradkhani, H.

    2015-12-01

    Global Sensitivity Analysis (GSA) approach helps identify the effectiveness of model parameters or inputs and thus provides essential information about the model performance. In this study, the effects of the Sacramento Soil Moisture Accounting (SAC-SMA) model parameters, forcing data, and initial conditions are analysed by using two GSA methods: Sobol' and Fourier Amplitude Sensitivity Test (FAST). The simulations are carried out over five sub-basins within the Columbia River Basin (CRB) for three different periods: one-year, four-year, and seven-year. Four factors are considered and evaluated by using the two sensitivity analysis methods: the simulation length, parameter range, model initial conditions, and the reliability of the global sensitivity analysis methods. The reliability of the sensitivity analysis results is compared based on 1) the agreement between the two sensitivity analysis methods (Sobol' and FAST) in terms of highlighting the same parameters or input as the most influential parameters or input and 2) how the methods are cohered in ranking these sensitive parameters under the same conditions (sub-basins and simulation length). The results show the coherence between the Sobol' and FAST sensitivity analysis methods. Additionally, it is found that FAST method is sufficient to evaluate the main effects of the model parameters and inputs. Another conclusion of this study is that the smaller parameter or initial condition ranges, the more consistency and coherence between the sensitivity analysis methods results.

  19. Measuring hepatic functional reserve using T1 mapping of Gd-EOB-DTPA enhanced 3T MR imaging: A preliminary study comparing with 99mTc GSA scintigraphy and signal intensity based parameters.

    PubMed

    Nakagawa, Masataka; Namimoto, Tomohiro; Shimizu, Kie; Morita, Kosuke; Sakamoto, Fumi; Oda, Seitaro; Nakaura, Takeshi; Utsunomiya, Daisuke; Shiraishi, Shinya; Yamashita, Yasuyuki

    2017-07-01

    To determine the utility of liver T1-mapping on gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) enhanced magnetic resonance (MR) imaging for the measurement of liver functional reserve compared with the signal intensity (SI) based parameters, technetium-99m-galactosyl serum albumin ( 99m Tc-GSA) scintigraphy and indocyanine green (ICG) clearance. This retrospective study included 111 patients (Child-Pugh-A 90; -B 21) performed with both Gd-EOB-DTPA enhanced liver MR imaging and 99m Tc-GSA (76 patients with ICG). Receiver operating characteristic (ROC) curve analysis was performed to compare diagnostic performances of T1-relaxation-time parameters [pre-(T1pre) and post-contrast (T1hb) Gd-EOB-DTPA], SI based parameters [relative enhancement (RE), liver-to-muscle-ratio (LMR), liver-to-spleen-ratio (LSR)] and 99m Tc-GSA scintigraphy blood clearance index (HH15)] for Child-Pugh classification. Pearson's correlation was used for comparisons among T1-relaxation-time parameters, SI-based parameters, HH15 and ICG. A significant difference was obtained for Child-Pugh classification with T1hb, ΔT1, all SI based parameters and HH15. T1hb had the highest AUC followed by RE, LMR, LSR, ΔT1, HH15 and T1pre. The correlation coefficients with HH15 were T1pre 0.22, T1hb 0.53, ΔT1 -0.38 of T1 relaxation parameters; RE -0.44, LMR -0.45, LSR -0.43 of SI-based parameters. T1hb was highest for correlation with HH15. The correlation coefficients with ICG were T1pre 0.29, T1hb 0.64, ΔT1 -0.42 of T1 relaxation parameters; RE -0.50, LMR -0.61, LSR -0.58 of SI-based parameters; 0.64 of HH15. Both T1hb and HH15 were highest for correlation with ICG. T1 relaxation time at post-contrast of Gd-EOB-DTPA (T1hb) was strongly correlated with ICG clearance and moderately correlated HH15 with 99m Tc-GSA. T1hb has the potential to provide robust parameter of liver functional reserve. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. 41 CFR 102-118.25 - Does GSA still require my agency to submit its overall transportation policies for approval?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT General Introduction... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does GSA still require...

  1. 41 CFR 101-1.4902 - GSA forms.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true GSA forms. 101-1.4902 Section 101-1.4902 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.49-Illustrations of Forms § 101-1.4902...

  2. 41 CFR 105-64.101 - Who is responsible for enforcing these rules?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.101 Who is responsible for enforcing these rules? GSA Heads of Services and Staff Offices and Regional Administrators are...

  3. 41 CFR 105-64.101 - Who is responsible for enforcing these rules?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.1-Policies and Responsibilities § 105-64.101 Who is responsible for enforcing these rules? GSA Heads of Services and Staff Offices and Regional Administrators are...

  4. 48 CFR 519.7001 - Scope of subpart.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Scope of subpart. 519.7001 Section 519.7001 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7001 Scope of subpart. The GSA Mentor...

  5. 41 CFR 101-26.306 - Planned requisitioning for GSA stock items.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Planned requisitioning for GSA stock items. 101-26.306 Section 101-26.306 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26...

  6. 41 CFR 101-39.207 - Reimbursement for services.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... sufficient to recover applicable costs. Failure by using agencies to reimburse GSA for vehicle services will... or neglect. (e) Agencies may be charged for recovery of expenses for repairs or services to GSA IFMS... services. 101-39.207 Section 101-39.207 Public Contracts and Property Management Federal Property...

  7. 76 FR 15856 - Standards of Conduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... codified GSA's supplemental standards of ethical conduct in the new 5 CFR part 6701. At that time, GSA... provided a number of cross- references to the new Government-wide standards of ethical conduct regulations... Management and Budget under 44 U.S.C. chapter 35. F. Small Business Regulatory Enforcement Fairness Act This...

  8. 76 FR 68759 - GSA Approves Renewal of North American Numbering Council Charter Through September 23, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... American Numbering Council Charter Through September 23, 2013 AGENCY: Federal Communications Commission... announcing GSA's approval of the renewal of the North American Numbering Council charter through September 23... American Numbering Council charter. DATES: Renewed through September 23, 2013. ADDRESSES: Competition...

  9. 41 CFR 101-30.603-2 - GSA Supply Catalog.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true GSA Supply Catalog. 101-30.603-2 Section 101-30.603-2 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30...

  10. 75 FR 48872 - General Services Administration Acquisition Regulation; Rewrite of GSAR Part 541, Acquisition of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... Acquisition Regulation; Rewrite of GSAR Part 541, Acquisition of Utility Services AGENCIES: Office of Acquisition Policy, General Services Administration (GSA). ACTION: Final rule. SUMMARY: The General Services Administration (GSA) is amending the General Services Administration Acquisition Regulation (GSAR) to improve the...

  11. 78 FR 73863 - Public Availability of General Services Administration FY 2013 Federal Activities Inventory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... GENERAL SERVICES ADMINISTRATION [Notice-MV-2013-03; Docket No. 2013-0002; Sequence 37] Public... Inventory AGENCY: General Services Administration (GSA). ACTION: Notice of public availability of FY 2013...) Circular A-76, General Services Administration (GSA) is publishing this notice to advise the public of the...

  12. 76 FR 63923 - Notice of Availability To Distribute a Final Environmental Impact Statement (FEIS) for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... and Environmental Design Green Building Rating System of the U.S. Green Building Council. Alternatives... International Falls, MN AGENCY: Public Buildings Service, General Services Administration (GSA). ACTION: Notice...: October 14, 2011. FOR FURTHER INFORMATION CONTACT: Donald R. Melcher, Jr., GSA Public Buildings Service...

  13. 41 CFR 102-118.530 - Will GSA instruct my agency's disbursing offices to offset unpaid TSP billings?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Claims and Appeal Procedures... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Will GSA instruct my...

  14. 41 CFR 102-85.195 - Does GSA provide special services?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Does GSA provide special services? 102-85.195 Section 102-85.195 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR...

  15. 41 CFR 105-55.016 - Interest, penalties, and administrative costs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Services Administration (GSA) will charge interest, penalties, and administrative costs on debts owed to.... (b) GSA will charge interest on debts owed the United States as follows: (1) Interest will accrue... contract, repayment agreement, or by statute, the rate of interest charged will be the rate established...

  16. 75 FR 16484 - Agency Information Collection Activities; Proposed Collection; Comment Request; Open Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ...-mail address: [email protected] . SUPPLEMENTARY INFORMATION: What Information Is GSA Particularly...., permitting electronic submission of responses. What Should I Consider When I Prepare My Comments for GSA? You... page of your response. You may also provide the Federal Register citation. What Information Collection...

  17. 41 CFR 105-64.601 - Procedures for establishing system of records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... establishing system of records. 105-64.601 Section 105-64.601 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.6-Establishing or Revising Systems of Records in GSA...

  18. 41 CFR 105-60.305-3 - GSA records available without charge.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false GSA records available without charge. 105-60.305-3 Section 105-60.305-3 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General...

  19. 41 CFR 105-64.601 - Procedures for establishing system of records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... establishing system of records. 105-64.601 Section 105-64.601 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.6-Establishing or Revising Systems of Records in GSA...

  20. 41 CFR 105-60.305-4 - GSA records available at a fee.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false GSA records available at a fee. 105-60.305-4 Section 105-60.305-4 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...

  1. 41 CFR 105-60.305-4 - GSA records available at a fee.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false GSA records available at a fee. 105-60.305-4 Section 105-60.305-4 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...

  2. 41 CFR 105-64.601 - Procedures for establishing system of records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... establishing system of records. 105-64.601 Section 105-64.601 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.6-Establishing or Revising Systems of Records in GSA...

  3. 41 CFR 105-60.305-3 - GSA records available without charge.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false GSA records available without charge. 105-60.305-3 Section 105-60.305-3 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General...

  4. 41 CFR 105-60.305-4 - GSA records available at a fee.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false GSA records available at a fee. 105-60.305-4 Section 105-60.305-4 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services...

  5. 41 CFR 105-60.305-3 - GSA records available without charge.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false GSA records available without charge. 105-60.305-3 Section 105-60.305-3 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General...

  6. 41 CFR 105-64.601 - Procedures for establishing system of records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... establishing system of records. 105-64.601 Section 105-64.601 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration 64-GSA PRIVACY ACT RULES 64.6-Establishing or Revising Systems of Records in GSA...

  7. Facility Management Child Care Resource Book. Child Care Operations Center of Expertise.

    ERIC Educational Resources Information Center

    General Services Administration, Washington, DC. Public Buildings Service.

    This guidebook provides maintenance and operations guidelines for managing General Services Administration (GSA) child care centers within the same standards and level of a GSA operated facility. Areas covered address cleaning standards and guidelines; equipment funding and inventory; maintenance of living environments and problem areas;…

  8. 41 CFR 102-118.440 - What are the postpayment audit responsibilities and roles of the GSA Audit Division?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... audit responsibilities and roles of the GSA Audit Division? 102-118.440 Section 102-118.440 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits...

  9. 41 CFR 101-39.304 - Modification or installation of accessory equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System Vehicles § 101-39.304 Modification or installation of accessory equipment. The modification of a GSA Interagency Fleet Management System (IFMS) vehicle or the permanent installation of...

  10. 41 CFR 101-39.206 - Seasonal or unusual requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services... requirements for vehicles or related services shall inform the GSA IFMS fleet management center as far in... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Seasonal or unusual...

  11. 41 CFR 101-39.102-1 - Records, facilities, personnel, and appropriations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.102-1 Records, facilities, personnel, and appropriations. (a) If GSA decides to establish a fleet management system, GSA, with the assistance of the...

  12. 41 CFR 109-39.300 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System... operators and passengers in GSA Interagency Fleet Management System (IFMS) motor vehicles are aware of the... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false General. 109-39.300...

  13. 77 FR 40884 - Office of the Chief Information Officer; Information Collection; Temporary Contractor Information...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... Management and Budget (OMB) a request to review and approve a previously approved information collection... collection to make determinations on granting unescorted physical access to GSA-controlled facilities. The approval is critical for GSA to continue to make physical access determinations for temporary contractors...

  14. 41 CFR 101-26.507 - Security equipment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true Security equipment. 101... PROGRAM 26.5-GSA Procurement Programs § 101-26.507 Security equipment. Federal agencies and other activities authorized to purchase security equipment through GSA sources shall do so in accordance with the...

  15. 41 CFR 101-26.507 - Security equipment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Security equipment. 101... PROGRAM 26.5-GSA Procurement Programs § 101-26.507 Security equipment. Federal agencies and other activities authorized to purchase security equipment through GSA sources shall do so in accordance with the...

  16. 41 CFR 101-26.507 - Security equipment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Security equipment. 101... PROGRAM 26.5-GSA Procurement Programs § 101-26.507 Security equipment. Federal agencies and other activities authorized to purchase security equipment through GSA sources shall do so in accordance with the...

  17. 41 CFR 101-26.507 - Security equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Security equipment. 101... PROGRAM 26.5-GSA Procurement Programs § 101-26.507 Security equipment. Federal agencies and other activities authorized to purchase security equipment through GSA sources shall do so in accordance with the...

  18. 41 CFR 101-30.603-5 - Change bulletins.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603-5 Change bulletins. Changes to the GSA... Supply Catalog.” These change bulletins will serve as the media to notify agencies of additions...

  19. 41 CFR 101-30.603-5 - Change bulletins.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603-5 Change bulletins. Changes to the GSA... Supply Catalog.” These change bulletins will serve as the media to notify agencies of additions...

  20. 41 CFR 101-30.603-5 - Change bulletins.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603-5 Change bulletins. Changes to the GSA... Supply Catalog.” These change bulletins will serve as the media to notify agencies of additions...

  1. 41 CFR 101-30.603-5 - Change bulletins.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603-5 Change bulletins. Changes to the GSA... Supply Catalog.” These change bulletins will serve as the media to notify agencies of additions...

  2. 41 CFR 101-30.602 - Authority for issuance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.602 Authority for issuance. The GSA section of the Federal Supply Catalog is issued as an integral part of the Federal Supply Catalog and the Federal...

  3. 41 CFR 101-30.602 - Authority for issuance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.602 Authority for issuance. The GSA section of the Federal Supply Catalog is issued as an integral part of the Federal Supply Catalog and the Federal...

  4. 41 CFR 101-30.602 - Authority for issuance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.602 Authority for issuance. The GSA section of the Federal Supply Catalog is issued as an integral part of the Federal Supply Catalog and the Federal...

  5. 41 CFR 101-30.602 - Authority for issuance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.602 Authority for issuance. The GSA section of the Federal Supply Catalog is issued as an integral part of the Federal Supply Catalog and the Federal...

  6. 41 CFR 101-30.603-5 - Change bulletins.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.603-5 Change bulletins. Changes to the GSA... Supply Catalog.” These change bulletins will serve as the media to notify agencies of additions...

  7. 41 CFR 101-30.602 - Authority for issuance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 30-FEDERAL CATALOG SYSTEM 30.6-GSA Section of the Federal Supply Catalog § 101-30.602 Authority for issuance. The GSA section of the Federal Supply Catalog is issued as an integral part of the Federal Supply Catalog and the Federal...

  8. 41 CFR 105-62.103 - Access to GSA-originated materials.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administration 62-DOCUMENT SECURITY AND DECLASSIFICATION 62.1-Classified Materials § 105-62.103 Access to GSA..., provided that: (1) A written determination is made by the Administrator of General Services that such... element having classification jurisdiction for such information or material makes a written determination...

  9. EPA and GSA Webinar: E Scrap Management, Computers for Learning and the Federal Green Challenge

    EPA Pesticide Factsheets

    EPA and the General Services Administration (GSA) are hosting a webinar on May 2, 2018. Topics will include policies and procedures on E Scrap management, a review of the Computers For Leaning Program, and benefits of joining the Federal Green Challenge.

  10. 41 CFR 101-27.505 - Notice to activity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Notice to activity. 101-27.505 Section 101-27.505 Public Contracts and Property Management Federal Property Management...-Return of GSA Stock Items § 101-27.505 Notice to activity. GSA will provide notice to the offering...

  11. 41 CFR 101-26.505-7 - GSA assistance in selection of furniture and furnishings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true GSA assistance in... Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND..., upon request, furnish agencies with information on the types, styles, finishes, coverings, and colors...

  12. 76 FR 35218 - Federal Acquisition Regulation; Information Collection; Cost or Pricing Data Requirements and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-16

    ... INFORMATION CONTACT: Mr. Edward Chambers, Procurement Analyst, Acquisition Policy Division, GSA (202) 501-3221 or Edward.chambers@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose The Truth in Negotiations Act... Than Cost or Pricing Data, in all correspondence. Dated: June 7, 2011. Millisa Gary, Acting Director...

  13. 76 FR 15981 - Maximum Per Diem Rates for the States of California, Mississippi, New York, Pennsylvania, Texas...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... GENERAL SERVICES ADMINISTRATION [GSA Bulletin FTR 11-06; Docket 2011-0002; Sequence 2] Maximum Per Diem Rates for the States of California, Mississippi, New York, Pennsylvania, Texas, and Virginia AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Notice of Per...

  14. 78 FR 44325 - Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... developed under the guidelines of Executive Order 12866 ``Regulatory Planning and Review.'' GSA's purpose in.... GSA also invites interested persons to recommend existing significant regulations for review to... available online at www.reginfo.gov , in a format that offers users a greatly enhanced ability to obtain...

  15. 77 FR 58141 - Public Buildings Service; Information Collection; Art-in-Architecture Program National Artist...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... Buildings Service; Information Collection; Art-in- Architecture Program National Artist Registry (GSA Form... regarding Art-in Architecture Program National Artist Registry (GSA Form 7437). The Art-in-Architecture...-Architecture & Fine Arts Division (PCAC), 1800 F Street NW., Room 3305, Washington, DC 20405, at telephone(202...

  16. 75 FR 22805 - Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... GENERAL SERVICES ADMINISTRATION [Proposed GSA Bulletin FTR 10-XXX; Docket 2010-0009; Sequence 1] Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of Transaction... GSA is posting online a proposed FTR bulletin that contains the data dictionary that large Federal...

  17. Building a global schistosomiasis alliance: an opportunity to join forces to fight inequality and rural poverty.

    PubMed

    Savioli, Lorenzo; Albonico, Marco; Colley, Daniel G; Correa-Oliveira, Rodrigo; Fenwick, Alan; Green, Will; Kabatereine, Narcis; Kabore, Achille; Katz, Naftale; Klohe, Katharina; LoVerde, Philip T; Rollinson, David; Stothard, J Russell; Tchuem Tchuenté, Louis-Albert; Waltz, Johannes; Zhou, Xiao-Nong

    2017-03-23

    Schistosomiasis, one of the 17 neglected tropical diseases listed by the World Health Organization, presents a substantial public health and economic burden. Of the 261 million people requiring preventive chemotherapy for schistosomiasis in 2013, 92% of them lived in sub-Saharan Africa and only 12.7% received preventive chemotherapy. Moreover, in 2010, the WHO reported that schistosomiasis mortality could be as high as 280 000 per year in Africa alone.In May 2012 delegates to the sixty-fifth World Health Assembly adopted resolution WHA65.21 that called for the elimination of schistosomiasis, and foresees the regular treatment of at least 75% of school age children in at-risk areas. The resolution urged member states to intensify schistosomiasis control programmes and to initiate elimination campaigns where possible.Despite this, in June 2015, schistosomiasis was indicated to have the lowest level of preventive chemotherapy implementation in the spectrum of neglected tropical diseases. It was also highlighted as the disease most lacking in progress. This is perhaps unsurprising, given that it was also the only NTD with access to drug donations but without a coalition of stakeholders that collaborates to boost commitment and implementation.As a consequence, and to ensure that the WHO NTDs Roadmap Targets of 2012 and World Health Assembly Resolution WHA65.21 are met, the Global Schistosomiasis Alliance (GSA) has been set up. Diverse and representative, the GSA aims to be a partnership of endemic countries, academic and research institutions, international development agencies and foundations, international organizations, non-governmental development organizations, private sector companies and advocacy and resource mobilisation partners. Ultimately, the GSA calls for a partnership to work for the benefit of endemic countries by addressing health inequity and rural poverty.

  18. Advanced continuous cultivation methods for systems microbiology.

    PubMed

    Adamberg, Kaarel; Valgepea, Kaspar; Vilu, Raivo

    2015-09-01

    Increasing the throughput of systems biology-based experimental characterization of in silico-designed strains has great potential for accelerating the development of cell factories. For this, analysis of metabolism in the steady state is essential as only this enables the unequivocal definition of the physiological state of cells, which is needed for the complete description and in silico reconstruction of their phenotypes. In this review, we show that for a systems microbiology approach, high-resolution characterization of metabolism in the steady state--growth space analysis (GSA)--can be achieved by using advanced continuous cultivation methods termed changestats. In changestats, an environmental parameter is continuously changed at a constant rate within one experiment whilst maintaining cells in the physiological steady state similar to chemostats. This increases the resolution and throughput of GSA compared with chemostats, and, moreover, enables following of the dynamics of metabolism and detection of metabolic switch-points and optimal growth conditions. We also describe the concept, challenge and necessary criteria of the systematic analysis of steady-state metabolism. Finally, we propose that such systematic characterization of the steady-state growth space of cells using changestats has value not only for fundamental studies of metabolism, but also for systems biology-based metabolic engineering of cell factories.

  19. A surrogate model for thermal characteristics of stratospheric airship

    NASA Astrophysics Data System (ADS)

    Zhao, Da; Liu, Dongxu; Zhu, Ming

    2018-06-01

    A simple and accurate surrogate model is extremely needed to reduce the analysis complexity of thermal characteristics for a stratospheric airship. In this paper, a surrogate model based on the Least Squares Support Vector Regression (LSSVR) is proposed. The Gravitational Search Algorithm (GSA) is used to optimize hyper parameters. A novel framework consisting of a preprocessing classifier and two regression models is designed to train the surrogate model. Various temperature datasets of the airship envelope and the internal gas are obtained by a three-dimensional transient model for thermal characteristics. Using these thermal datasets, two-factor and multi-factor surrogate models are trained and several comparison simulations are conducted. Results illustrate that the surrogate models based on LSSVR-GSA have good fitting and generalization abilities. The pre-treated classification strategy proposed in this paper plays a significant role in improving the accuracy of the surrogate model.

  20. Comparison of Effective Medium Schemes For Seismic Velocities in Cracked Anisotropic Rock

    NASA Astrophysics Data System (ADS)

    Morshed, S.; Chesnokov, E.

    2017-12-01

    Understanding of elastic properties of reservoir rock is necessary for meaningful interpretation and analysis of seismic measurements. The elastic properties of a rock are controlled by the microstructural properties such as mineralogical composition, pore and crack distribution, texture and pore connectivity. However, seismic scale is much larger than microstructure scale. Understanding of macroscopic properties at relevant seismic scale (e.g. borehole sonic data) comes from effective medium theory (EMT). However, most of the effective medium theories fail at high crack density as the interactions of strain fields of the cracks can't be ignored. We compare major EMT schemes from low to high crack density. While at low crack density all method gives similar results, at high crack density they differ significantly. Then, we focus on generalized singular approximation (GSA) and effective field (EF) method as they allow cracks beyond the limit of dilute concentrations. Additionally, we use grain contact (GC) method to examine the stiffness constants of the rock matrix. We prepare simple models of a multiphase media containing low to high concentrations of isolated pores. Randomly oriented spherical pores and horizontally oriented ellipsoidal (aspect ratio =0.1) pores have been considered. For isolated spherical pores, all the three methods show exactly same or similar results. However, inclusion interactions are different in different directions in case of horizontal ellipsoidal pores and individual stiffness constants differ greatly from one method to another at different crack density. Stiffness constants remain consistent in GSA method whereas some components become unusual in EF method at a higher crack density (>0.15). Finally, we applied GSA method to interpret ultrasonic velocities of core samples. Mineralogical composition from X-ray diffraction (XRD) data and lab measured porosity data have been utilized. Both compressional and shear wave velocities from GSA method show good fit with the lab measured velocities.

  1. 76 FR 30942 - Notice of Availability of the Final Environmental Impact Statement for Improvements to the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... Calexico, California. The Final EIS provides GSA and its stakeholders an analysis of the environmental... Sheehan, NEPA Project Manager, Portfolio Management Division, Capital Investment Branch (9P2PTC), U.S.../nepalibrary . Dated: May 19, 2011. Samuel R. Mazzola, Director, Portfolio Management Division, Pacific Rim...

  2. 41 CFR 105-60.305-6 - Reviews.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Reviews. 105-60.305-6..., Policies, Interpretations, Manuals, and Instructions § 105-60.305-6 Reviews. (a) GSA will charge only commercial-use requesters for review time. (b) GSA will charge for the time spent in the following activities...

  3. 41 CFR 105-57.005 - Hearing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Hearing. 105-57.005...-ADMINISTRATION WAGE GARNISHMENT § 105-57.005 Hearing. (a) GSA will provide a hearing, which at the hearing... by GSA, the debtor submits a signed and dated written request for a hearing, to the official named in...

  4. 41 CFR 105-57.005 - Hearing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Hearing. 105-57.005...-ADMINISTRATION WAGE GARNISHMENT § 105-57.005 Hearing. (a) GSA will provide a hearing, which at the hearing... by GSA, the debtor submits a signed and dated written request for a hearing, to the official named in...

  5. 41 CFR 105-57.005 - Hearing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Hearing. 105-57.005...-ADMINISTRATION WAGE GARNISHMENT § 105-57.005 Hearing. (a) GSA will provide a hearing, which at the hearing... by GSA, the debtor submits a signed and dated written request for a hearing, to the official named in...

  6. 78 FR 79460 - Notification of GSA Strategic Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ...] Notification of GSA Strategic Plan AGENCY: Office of the Chief Financial Officer, U.S. General Services..., Office of the Chief Financial Officer, 1800 F Street NW., Washington, DC 20405. FOR FURTHER INFORMATION... Officer, Office of the Chief Financial Officer. [FR Doc. 2013-31168 Filed 12-27-13; 8:45 am] BILLING CODE...

  7. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... under the Federal Records Act, especially with regards to sharing best practices, training, standards... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Why does GSA require annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management...

  8. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... under the Federal Records Act, especially with regards to sharing best practices, training, standards... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Why does GSA require annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management...

  9. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... under the Federal Records Act, especially with regards to sharing best practices, training, standards... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Why does GSA require annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management...

  10. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... under the Federal Records Act, especially with regards to sharing best practices, training, standards... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Why does GSA require annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management...

  11. 41 CFR 102-192.95 - Why does GSA require annual mail management reports?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... under the Federal Records Act, especially with regards to sharing best practices, training, standards... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Why does GSA require annual mail management reports? 102-192.95 Section 102-192.95 Public Contracts and Property Management...

  12. 41 CFR 101-26.501-7 - Sale of vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Sale of vehicles. 101-26... PROGRAM 26.5-GSA Procurement Programs § 101-26.501-7 Sale of vehicles. GSA will not solicit trade-in bids when purchasing new motor vehicles for replacement purposes because experience has shown that suppliers...

  13. 41 CFR 101-26.501-7 - Sale of vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Sale of vehicles. 101-26... PROGRAM 26.5-GSA Procurement Programs § 101-26.501-7 Sale of vehicles. GSA will not solicit trade-in bids when purchasing new motor vehicles for replacement purposes because experience has shown that suppliers...

  14. 41 CFR 101-5.104-5 - Designating agency representatives.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... each agency receiving a GSA notice regarding a scheduled feasibility study will be requested to designate one or more officials at the location where the study will be made who may consult with authorized... review of the feasibility of the proposed centralized service shall be made available to GSA through the...

  15. 41 CFR 101-5.104-5 - Designating agency representatives.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... each agency receiving a GSA notice regarding a scheduled feasibility study will be requested to designate one or more officials at the location where the study will be made who may consult with authorized... review of the feasibility of the proposed centralized service shall be made available to GSA through the...

  16. 75 FR 78994 - Notice of Intent To Prepare an Environmental Assessment, Request for Comments on Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... project, GSA proposes to relocate its current operations from the Bannister Federal Complex in Kansas City... increment financing (TIF) district, on the East-side of downtown, in Missouri's 5th Congressional District... the proposed project. GSA will also evaluate the ``No Action'' and other reasonable alternatives to...

  17. 41 CFR 102-33.40 - What are GSA's responsibilities for Federal aviation management?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... developing policy for managing Government aircraft; and (c) A management information system to collect... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are GSA's responsibilities for Federal aviation management? 102-33.40 Section 102-33.40 Public Contracts and Property...

  18. 41 CFR 101-6.2103 - What programs and activities of GSA are subject to these regulations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true What programs and... Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS...? The Administrator publishes in the Federal Register a list of GSA's programs and activities that are...

  19. 41 CFR 102-72.50 - What are Executive agencies' responsibilities under a delegation of real property management and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are Executive agencies' responsibilities under a delegation of real property management and operation authority from GSA... property management and operation authority from GSA? With this delegation, Executive agencies have the...

  20. 41 CFR 102-85.10 - What is the scope of this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Pricing Policy-General § 102-85.10 What is the scope of this part? (a) This part describes GSA policy and principles for the assignment and occupancy of space under its control and the...

  1. 41 CFR 102-118.445 - Must my agency pay for a postpayment audit when using the GSA Audit Division?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... postpayment audit when using the GSA Audit Division? 102-118.445 Section 102-118.445 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits § 102-118...

  2. 41 CFR 101-26.501-9 - Centralized motor vehicle leasing program.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true Centralized motor vehicle...-PROCUREMENT SOURCES AND PROGRAM 26.5-GSA Procurement Programs § 101-26.501-9 Centralized motor vehicle leasing program. GSA has a centralized leasing program to provide an additional source of motor vehicle support to...

  3. 75 FR 26991 - Notice of Realty Action; Competitive Sale of Public Land in Deschutes County, Oregon

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... will be conducted by the United States General Services Administration (GSA) as an online auction, at GSA's Web site http://www.auctionrp.com . DATES: This notice initiates the public comment period and... value, as approved by the Department of the Interior, Appraisal Services Directorate. The properties are...

  4. 41 CFR 101-39.404 - Claims in favor of the Government.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.4-Accidents and Claims § 101-39.404 Claims in favor of... Interagency Fleet Management System (IFMS) vehicle is at fault and that party can be reasonably identified... pertaining to the accident and its investigation to the servicing GSA IFMS fleet management center. The GSA...

  5. 41 CFR 102-71.20 - What definitions apply to GSA's real property policies?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... planning, engineering, architectural work, and other similar actions. Carpool means a group of two or more... tested in accordance with the American Society for Testing and Materials, Test E 84, Surface Burning... space in a facility under GSA's custody and control. Occupant Emergency Plan means procedures developed...

  6. 41 CFR 102-71.20 - What definitions apply to GSA's real property policies?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... planning, engineering, architectural work, and other similar actions. Carpool means a group of two or more... tested in accordance with the American Society for Testing and Materials, Test E 84, Surface Burning... space in a facility under GSA's custody and control. Occupant Emergency Plan means procedures developed...

  7. 75 FR 6032 - Property Obtained Through the Use of Charge Cards; Notice of GSA Bulletin FMR B-25

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ...: Notice of a bulletin. SUMMARY: This notice announces GSA Federal Management Regulation (FMR) Bulletin B... Policy, Office of Travel, Transportation and Asset Management, at (202) 501- 1777. Please cite Bulletin... streamlining procurement of needed items, the property obtained in this way presents special management and...

  8. 41 CFR 102-37.90 - What are GSA's responsibilities in the donation of surplus property?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... American National Red Cross property (generally blood plasma and related medical materials) originally... (GSA) is responsible for supervising and directing the disposal of surplus personal property. In... property is surplus to the needs of the Government; (b) Allocates and transfers surplus property on a fair...

  9. 41 CFR 102-37.90 - What are GSA's responsibilities in the donation of surplus property?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... American National Red Cross property (generally blood plasma and related medical materials) originally... (GSA) is responsible for supervising and directing the disposal of surplus personal property. In... property is surplus to the needs of the Government; (b) Allocates and transfers surplus property on a fair...

  10. 41 CFR 102-37.90 - What are GSA's responsibilities in the donation of surplus property?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... American National Red Cross property (generally blood plasma and related medical materials) originally... (GSA) is responsible for supervising and directing the disposal of surplus personal property. In... property is surplus to the needs of the Government; (b) Allocates and transfers surplus property on a fair...

  11. 41 CFR 102-37.90 - What are GSA's responsibilities in the donation of surplus property?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... American National Red Cross property (generally blood plasma and related medical materials) originally... (GSA) is responsible for supervising and directing the disposal of surplus personal property. In... property is surplus to the needs of the Government; (b) Allocates and transfers surplus property on a fair...

  12. 41 CFR 102-37.90 - What are GSA's responsibilities in the donation of surplus property?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... American National Red Cross property (generally blood plasma and related medical materials) originally... (GSA) is responsible for supervising and directing the disposal of surplus personal property. In... property is surplus to the needs of the Government; (b) Allocates and transfers surplus property on a fair...

  13. 48 CFR 519.7014 - Internal controls.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Internal controls. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7014 Internal controls. (a) The GSA Mentor-Protégé Program Manager will manage the Program. Internal controls will be established by...

  14. 48 CFR 519.7014 - Internal controls.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Internal controls. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7014 Internal controls. (a) The GSA Mentor-Protégé Program Manager will manage the Program. Internal controls will be established by...

  15. 48 CFR 519.7014 - Internal controls.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Internal controls. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7014 Internal controls. (a) The GSA Mentor-Protégé Program Manager will manage the Program. Internal controls will be established by...

  16. 48 CFR 519.7014 - Internal controls.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Internal controls. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7014 Internal controls. (a) The GSA Mentor-Protégé Program Manager will manage the Program. Internal controls will be established by...

  17. 48 CFR 519.7014 - Internal controls.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Internal controls. 519... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7014 Internal controls. (a) The GSA Mentor-Protégé Program Manager will manage the Program. Internal controls will be established by...

  18. 77 FR 58996 - Multiple Award Schedule (MAS) Program Continuous Open Season-Operational Change; Extension of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-25

    ... AGENCY: Federal Acquisition Service (FAS), General Services Administration (GSA). ACTION: Notice with a...), Federal Acquisition Service (FAS) issued a notice on July 23, 2012. The comment period is extended to... Administration (GSA), Federal Acquisition Service (FAS) published a notice in the Federal Register at 77 FR 43084...

  19. 41 CFR 101-27.501 - Eligibility for return.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Eligibility for return. 101-27.501 Section 101-27.501 Public Contracts and Property Management Federal Property Management...-Return of GSA Stock Items § 101-27.501 Eligibility for return. GSA stock items for which no current or...

  20. 41 CFR 105-55.024 - Consideration of tax consequences to the Government.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... consequences to the Government. 105-55.024 Section 105-55.024 Public Contracts and Property Management Federal... consequences to the Government. In negotiating a compromise, the General Services Administration (GSA) may consider the tax consequences to the Government. In particular, GSA may consider requiring a waiver of tax...

  1. 77 FR 204 - Federal Acquisition Regulation; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ...), General Services Administration (GSA), and National Aeronautics and Space Administration (NASA). ACTION... Governmentwide Policy. Therefore, DoD, GSA, and NASA amend 48 CFR parts 4, 8, 15, 19, 22, 23, 28, 42, and 52 as... removing from paragraph (a)(2) ``http:// www.epa.gov/epaoswer/non-hw/procure/backgrnd.htm'' and adding...

  2. 77 FR 26763 - General Services Administration Acquisition Regulation; Submission for OMB Review; Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... Claims, regarding final payment under construction and building services contract. GSA Form 1142 was... construction and building services contractors to submit a release of claims before final payment is made to... (GSAR Parts 532 and 552.232-72; GSA Form 1142 Release of Claims) AGENCY: Office of the Chief Acquisition...

  3. 77 FR 2726 - General Services Administration Acquisition Regulation; Information Collection; Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... Claims, regarding final payment under construction and building services contract. GSA Form 1142 was... (GSAR Part 532 and 552.232-72; GSA Form 1142 Release of Claims) AGENCY: Office of the Chief Acquisition... have used this form to achieve uniformity and consistency in the release of claims process. Public...

  4. 5 CFR 6701.103 - Prohibited purchases of property sold by GSA.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Prohibited purchases of property sold by... STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE GENERAL SERVICES ADMINISTRATION § 6701.103 Prohibited purchases of property sold by GSA. (a) General prohibition. Except as provided in paragraphs (b) and (c) of...

  5. 5 CFR 6701.104 - Prohibited purchases of real estate by certain GSA employees involved in the acquisition or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Prohibited purchases of real estate by... Administrative Personnel GENERAL SERVICES ADMINISTRATION SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE GENERAL SERVICES ADMINISTRATION § 6701.104 Prohibited purchases of real estate by certain GSA...

  6. 41 CFR 102-84.50 - May the GSA Form 1166 be used to report information?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May the GSA Form 1166 be used to report information? 102-84.50 Section 102-84.50 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 84...

  7. 41 CFR 102-85.120 - What is shell Rent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is shell Rent? 102-85.120 Section 102-85.120 Public Contracts and Property Management Federal Property Management... GSA SPACE Rent Charges § 102-85.120 What is shell Rent? Shell Rent is that portion of GSA Rent charged...

  8. 41 CFR 102-85.120 - What is shell Rent?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What is shell Rent? 102-85.120 Section 102-85.120 Public Contracts and Property Management Federal Property Management... GSA SPACE Rent Charges § 102-85.120 What is shell Rent? Shell Rent is that portion of GSA Rent charged...

  9. Risk analysis of the governance system affecting outcomes in the Great Barrier Reef.

    PubMed

    Dale, Allan P; Vella, Karen; Pressey, Robert L; Brodie, Jon; Gooch, Margaret; Potts, Ruth; Eberhard, Rachel

    2016-12-01

    The state and trend of the Great Barrier Reef's (GBR's) ecological health remains problematic, influencing United Nations Educational, Scientific and Cultural Organization (UNESCO) statements regarding GBR governance. While UNESCO's concerns triggered separate strategic assessments by the Australian and Queensland governments, there has been no independent and integrated review of the key risks within the overall system of governance influencing GBR outcomes. As a case study of international significance, this paper applies Governance Systems Analysis (GSA), a novel analytical framework that identifies the governance themes, domains and subdomains most likely to influence environmental and socio-economic outcomes in complex natural systems. This GBR-focussed application of GSA identifies governance subdomains that present high, medium, or low risk of failure to produce positive outcomes for the Reef. This enabled us to determine that three "whole of system" governance problems could undermine GBR outcomes. First, we stress the integrative importance of the Long Term Sustainability Plan (LTSP) Subdomain. Sponsored by the Australian and Queensland governments, this subdomain concerns the primary institutional arrangements for coordinated GBR planning and delivery, but due to its recent emergence, it faces several internal governance challenges. Second, we find a major risk of implementation failure in the achievement of GBR water quality actions due to a lack of system-wide focus on building strong and stable delivery systems at catchment scale. Finally, we conclude that the LTSP Subdomain currently has too limited a mandate/capacity to influence several high-risk subdomains that have not been, but must be more strongly aligned with Reef management (e.g. the Greenhouse Gas Emission Management Subdomain). Our analysis enables exploration of governance system reforms needed to address environmental trends in the GBR and reflects on the potential application of GSA in other complex land and sea-scapes across the globe. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. 48 CFR 519.7017 - Contract clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7017 Contract clauses. (a) The contracting officer shall insert the clause at 552.219-75, GSA Mentor-Protégé Program, in all unrestricted... small business protégé. (b) The contracting officer shall insert the clause at 552.219-76, Mentor...

  11. Gay-Straight Alliance (GSA) Members' Engagement with Sex Education in Canadian High Schools

    ERIC Educational Resources Information Center

    Lapointe, Alicia

    2014-01-01

    This paper offers an examination of gay-straight alliance (GSA) members' engagement with sex education, sexual health, and prejudice and discrimination in Canadian public high schools. It explores how five students' (four straight and one gay-identifying) participation in GSAs served as a springboard for learning about and challenging stereotypes;…

  12. 41 CFR 105-55.027 - Suspension of collection activity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to the 10-year limitation for administrative offset prescribed by 31 U.S.C. 3716(e)(1); or (3) The... waiver or review is frivolous or was made primarily to delay collection. (d) When GSA learns a bankruptcy... establish the automatic stay has been lifted or is no longer in effect. GSA will, if legally permitted, take...

  13. 41 CFR 101-26.505-3 - Requests to procure similar items from sources other than GSA supply sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Requests to procure... Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.5-GSA Procurement Programs § 101-26...

  14. 41 CFR 102-85.120 - What is shell Rent?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What is shell Rent? 102... GSA SPACE Rent Charges § 102-85.120 What is shell Rent? Shell Rent is that portion of GSA Rent charged for the building envelope and land. (See § 102-85.35 for the definition of building shell.) ...

  15. 41 CFR 102-192.90 - What must we include in our annual mail management report to GSA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What must we include in our annual mail management report to GSA? 102-192.90 Section 102-192.90 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION...

  16. 41 CFR 102-192.170 - What are GSA's responsibilities in mail management?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... guidance and assistance to Federal agencies to ensure economical and efficient records management. 44 U.S.C. § 2901(2) and (4) (C) define the processing of mail by Federal agencies as part of records management. In... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What are GSA's...

  17. 41 CFR 102-192.170 - What are GSA's responsibilities in mail management?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... guidance and assistance to Federal agencies to ensure economical and efficient records management. 44 U.S.C. § 2901(2) and (4) (C) define the processing of mail by Federal agencies as part of records management. In... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What are GSA's...

  18. 77 FR 3775 - Notice of Availability of the Environmental Assessment for Proposed Federal Building Kansas City, MO

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... in Kansas City, Missouri. Through the project, GSA proposes to relocate its current operations from... downtown East Village development and tax increment financing (TIF) district, on the East-side of downtown... result of the construction and operation of the proposed project. GSA also evaluates a ``No Action'' and...

  19. 41 CFR 102-72.95 - What are the requirements for obtaining a security delegation of authority from GSA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the requirements for obtaining a security delegation of authority from GSA? An Executive agency may... PBS. The delegation may be granted where the requesting agency demonstrates a compelling need for the delegated authority and the delegation is not inconsistent with the authorities of any other law enforcement...

  20. Leveraging Lighting for Energy Savings: GSA Northwest/Artic Region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2016-01-01

    Case study describes how the Northwest/Arctic Region branch of the General Services Administration (GSA) improved safety and energy efficiency in its Fairbanks Federal Building parking garage used by federal employees, U.S. Marshals, and the District Court. A 74% savings was realized by replacing 220 high-pressure sodium fixtures with 220 light-emitting diode fixtures.

  1. 41 CFR 102-72.55 - What are the requirements for obtaining a delegation of real property management and operation...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... requirements for obtaining a delegation of real property management and operation authority from GSA? 102-72.55... operation authority from GSA? An Executive agency may be delegated real property management and operation...) Demonstrates that it can perform the delegated real property management and operation responsibilities. ...

  2. 41 CFR 102-118.510 - Can my agency revise or alter a GSA Form 7931, Certificate of Settlement?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Can my agency revise or... Information for All Claims § 102-118.510 Can my agency revise or alter a GSA Form 7931, Certificate of...

  3. 41 CFR 102-85.60 - Who can execute an OA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Who can execute an OA... GSA SPACE Occupancy Agreement § 102-85.60 Who can execute an OA? Authorized GSA and customer agency officials who can commit or obligate the funds of their respective agencies can execute an OA. Higher level...

  4. 41 CFR 101-26.309 - Cancellation of orders for GSA stock items.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Cancellation of orders for GSA stock items. 101-26.309 Section 101-26.309 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.3...

  5. A Program Review of a Middle School Gay-Straight Alliance Club

    ERIC Educational Resources Information Center

    Quasha, Scott; McCabe, Paul C.; Ortiz, Samuel O.

    2014-01-01

    This program review examined a middle school Gay-Straight Alliance (GSA) club within a northeastern suburban school situated in a large metropolitan area. The GSA was the first in the region to start exclusively in a standalone middle school. The review was accomplished through a staff survey comparing school climates for lesbian, gay, bisexual,…

  6. 41 CFR 105-64.801 - How to file a privacy complaint.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false How to file a privacy... Administration 64-GSA PRIVACY ACT RULES 64.8-Privacy Complaints § 105-64.801 How to file a privacy complaint. E-mail your complaint to [email protected] or send to: GSA Privacy Act Officer (CIB), General...

  7. 41 CFR 105-64.801 - How to file a privacy complaint.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false How to file a privacy... Administration 64-GSA PRIVACY ACT RULES 64.8-Privacy Complaints § 105-64.801 How to file a privacy complaint. E-mail your complaint to [email protected] or send to: GSA Privacy Act Officer (CIB), General...

  8. 41 CFR 102-85.170 - Can flexitime and other alternative work schedules cost the customer agency more?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Can flexitime and other alternative work schedules cost the customer agency more? Yes, GSA customers who extend their regular work schedule by a system of flexible hours shall reimburse GSA for its... alternative work schedules cost the customer agency more? 102-85.170 Section 102-85.170 Public Contracts and...

  9. 41 CFR 105-64.801 - How to file a privacy complaint.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How to file a privacy... Administration 64-GSA PRIVACY ACT RULES 64.8-Privacy Complaints § 105-64.801 How to file a privacy complaint. E-mail your complaint to [email protected] or send to: GSA Privacy Act Officer (CIB), General...

  10. 41 CFR 105-64.803 - How will my appeal be handled?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administration 64-GSA PRIVACY ACT RULES 64.8-Privacy Complaints § 105-64.803 How will my appeal be handled? The Privacy Act Officer will consult with legal counsel and the appropriate GSA officials concerning your appeal. The decision will be made by the Senior Agency Official for Privacy. The decision will be sent...

  11. 76 FR 14559 - Federal Acquisition Regulation; Justification and Approval of Sole-Source 8(a) Contracts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... Space Administration (NASA). ACTION: Interim rule. SUMMARY: DoD, GSA, and NASA are issuing an interim..., and NASA are issuing an interim rule amending the FAR, to implement section 811 of the National... meetings, DoD, GSA, and NASA weighed the costs and benefits of publishing this rule as proposed or interim...

  12. GSA Advisors' Self-Efficacy Related to LGBT Youth of Color and Transgender Youth

    ERIC Educational Resources Information Center

    Poteat, V. Paul; Scheer, Jillian R.

    2016-01-01

    Gay-Straight Alliances (GSAs) serve lesbian, gay, bisexual, transgender (LGBT) and heterosexual youth from diverse backgrounds. Although some attention has been given to youth members in general, little attention has been given to adult advisors. Among 47 GSA advisors from 33 high schools (39 cisgender female, 8 cisgender male), the authors…

  13. 77 FR 73657 - Public Buildings Service; Submission for OMB Review; Art-in-Architecture Program National Artist...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... Buildings Service; Submission for OMB Review; Art-in- Architecture Program National Artist Registry (GSA... Architecture Program National Artist Registry (GSA Form 7437). A notice was published in the Federal Register at 77 FR 58141, on September 19, 2012. No comments were received. The Art-in-Architecture Program is...

  14. Ligand Binding Site Detection by Local Structure Alignment and Its Performance Complementarity

    PubMed Central

    Lee, Hui Sun; Im, Wonpil

    2013-01-01

    Accurate determination of potential ligand binding sites (BS) is a key step for protein function characterization and structure-based drug design. Despite promising results of template-based BS prediction methods using global structure alignment (GSA), there is a room to improve the performance by properly incorporating local structure alignment (LSA) because BS are local structures and often similar for proteins with dissimilar global folds. We present a template-based ligand BS prediction method using G-LoSA, our LSA tool. A large benchmark set validation shows that G-LoSA predicts drug-like ligands’ positions in single-chain protein targets more precisely than TM-align, a GSA-based method, while the overall success rate of TM-align is better. G-LoSA is particularly efficient for accurate detection of local structures conserved across proteins with diverse global topologies. Recognizing the performance complementarity of G-LoSA to TM-align and a non-template geometry-based method, fpocket, a robust consensus scoring method, CMCS-BSP (Complementary Methods and Consensus Scoring for ligand Binding Site Prediction), is developed and shows improvement on prediction accuracy. The G-LoSA source code is freely available at http://im.bioinformatics.ku.edu/GLoSA. PMID:23957286

  15. Targets for Marine Corps Purchasing and Supply Management Initiatives: Spend Analysis Findings

    DTIC Science & Technology

    2011-01-01

    TRANSPORTATION INTERNATIONAL AFFAIRS LAW AND BUSINESS NATIONAL SECURITY POPULATION AND AGING PUBLIC SAFETY SCIENCE AND TECHNOLOGY TERRORISM AND...States Transportation Command UNICOR Federal Prison Industries, Inc. USMC United States Marine Corps WHS/SIAD Washington Headquarters Services...Services Admin- istration (GSA), and the United States Transportation Command (TRANSCOM), as well as via Military Interdepartmental Purchase Requests

  16. Terrain Dynamics Analysis Using Space-Time Domain Hypersurfaces and Gradient Trajectories Derived From Time Series of 3D Point Clouds

    DTIC Science & Technology

    2015-08-01

    optimized space-time interpolation method. Tangible geospatial modeling system was further developed to support the analysis of changing elevation surfaces...Evolution Mapped by Terrestrial Laser Scanning, talk, AGU Fall 2012 *Hardin E, Mitas L, Mitasova H., Simulation of Wind -Blown Sand for...Geomorphological Applications: A Smoothed Particle Hydrodynamics Approach, GSA 2012 *Russ, E. Mitasova, H., Time series and space-time cube analyses on

  17. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data.

    PubMed

    Hettne, Kristina M; Boorsma, André; van Dartel, Dorien A M; Goeman, Jelle J; de Jong, Esther; Piersma, Aldert H; Stierum, Rob H; Kleinjans, Jos C; Kors, Jan A

    2013-01-29

    Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set analysis (GSA) methods for chemical treatment identification, for pharmacological mechanism elucidation, and for comparing compound toxicity profiles. We created 30,211 chemical response-specific gene sets for human and mouse by next-gen TM, and derived 1,189 (human) and 588 (mouse) gene sets from the Comparative Toxicogenomics Database (CTD). We tested for significant differential expression (SDE) (false discovery rate -corrected p-values < 0.05) of the next-gen TM-derived gene sets and the CTD-derived gene sets in gene expression (GE) data sets of five chemicals (from experimental models). We tested for SDE of gene sets for six fibrates in a peroxisome proliferator-activated receptor alpha (PPARA) knock-out GE dataset and compared to results from the Connectivity Map. We tested for SDE of 319 next-gen TM-derived gene sets for environmental toxicants in three GE data sets of triazoles, and tested for SDE of 442 gene sets associated with embryonic structures. We compared the gene sets to triazole effects seen in the Whole Embryo Culture (WEC), and used principal component analysis (PCA) to discriminate triazoles from other chemicals. Next-gen TM-derived gene sets matching the chemical treatment were significantly altered in three GE data sets, and the corresponding CTD-derived gene sets were significantly altered in five GE data sets. Six next-gen TM-derived and four CTD-derived fibrate gene sets were significantly altered in the PPARA knock-out GE dataset. None of the fibrate signatures in cMap scored significant against the PPARA GE signature. 33 environmental toxicant gene sets were significantly altered in the triazole GE data sets. 21 of these toxicants had a similar toxicity pattern as the triazoles. We confirmed embryotoxic effects, and discriminated triazoles from other chemicals. Gene set analysis with next-gen TM-derived chemical response-specific gene sets is a scalable method for identifying similarities in gene responses to other chemicals, from which one may infer potential mode of action and/or toxic effect.

  18. Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

    PubMed Central

    2013-01-01

    Background Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set analysis (GSA) methods for chemical treatment identification, for pharmacological mechanism elucidation, and for comparing compound toxicity profiles. Methods We created 30,211 chemical response-specific gene sets for human and mouse by next-gen TM, and derived 1,189 (human) and 588 (mouse) gene sets from the Comparative Toxicogenomics Database (CTD). We tested for significant differential expression (SDE) (false discovery rate -corrected p-values < 0.05) of the next-gen TM-derived gene sets and the CTD-derived gene sets in gene expression (GE) data sets of five chemicals (from experimental models). We tested for SDE of gene sets for six fibrates in a peroxisome proliferator-activated receptor alpha (PPARA) knock-out GE dataset and compared to results from the Connectivity Map. We tested for SDE of 319 next-gen TM-derived gene sets for environmental toxicants in three GE data sets of triazoles, and tested for SDE of 442 gene sets associated with embryonic structures. We compared the gene sets to triazole effects seen in the Whole Embryo Culture (WEC), and used principal component analysis (PCA) to discriminate triazoles from other chemicals. Results Next-gen TM-derived gene sets matching the chemical treatment were significantly altered in three GE data sets, and the corresponding CTD-derived gene sets were significantly altered in five GE data sets. Six next-gen TM-derived and four CTD-derived fibrate gene sets were significantly altered in the PPARA knock-out GE dataset. None of the fibrate signatures in cMap scored significant against the PPARA GE signature. 33 environmental toxicant gene sets were significantly altered in the triazole GE data sets. 21 of these toxicants had a similar toxicity pattern as the triazoles. We confirmed embryotoxic effects, and discriminated triazoles from other chemicals. Conclusions Gene set analysis with next-gen TM-derived chemical response-specific gene sets is a scalable method for identifying similarities in gene responses to other chemicals, from which one may infer potential mode of action and/or toxic effect. PMID:23356878

  19. 48 CFR 519.7008 - Selection of protégé firms.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS GSA Mentor-Protégé Program 519.7008 Selection of protégé firms. (a) Mentor firms will be solely responsible for selecting protégé firms. Mentors are encouraged to... subcontractor or a newly selected subcontractor for the prime contractor's GSA contract. (b) Mentor firms may...

  20. 41 CFR 102-118.550 - How does a TSP file an administrative claim using EDI or other electronic means?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... administrative claim using EDI or other electronic means? 102-118.550 Section 102-118.550 Public Contracts and... EDI or other electronic means? The medium and precise format of data for an administrative claim filed electronically must be approved in advance by the GSA Audit Division. GSA will use an authenticating EDI...

  1. 41 CFR 102-118.260 - Must my agency send all quotations, tenders, or contracts with a TSP to GSA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... quotations, tenders, or contracts with a TSP to GSA? 102-118.260 Section 102-118.260 Public Contracts and... REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Use of Government Billing Documents Quotations, Tenders Or Contracts § 102-118.260 Must my agency send all quotations, tenders, or contracts with a TSP to...

  2. Advanced Vehicle and Power Initiative

    DTIC Science & Technology

    2010-07-29

    optimize vehicle operation, and capture vehicle kinetic energy during braking ( regenerative energy). As much as two-thirds of this imported oil comes... categories . Figure 4 provides a visual representation of many of the HEV and BEV options available on the 2010 GSA Schedule. Figure 4 - GSA...gallon • Renewable energy generated 24 • Vehicle miles driven by vehicle category • Implementation costs – Infrastructure modifications required

  3. 41 CFR 102-74.145 - What information must a Federal agency submit to GSA after the agency has identified a need for...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Asset Services § 102-74.145 What information must a Federal agency submit to GSA after... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What information must a...

  4. 41 CFR 102-33.385 - Is any civilian executive agency exempt from the requirement to report information to GSA on...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Is any civilian executive agency exempt from the requirement to report information to GSA on Government aircraft? 102-33.385 Section 102-33.385 Public Contracts and Property Management Federal Property Management Regulations System...

  5. 41 CFR 102-42.130 - Are there special requirements for the donation of gifts and decorations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: (a) The donee must display or use the gift or decoration in accordance with its GSA-approved letter... has been used for the purpose stated in the letter of intent for a period of 10 years, except that GSA..., trade, lease, lend, bail, encumber, cannibalize or dismantle for parts, or otherwise dispose of the...

  6. General Separations Area (GSA) Groundwater Flow Model Update: Hydrostratigraphic Data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bagwell, L.; Bennett, P.; Flach, G.

    2017-02-21

    This document describes the assembly, selection, and interpretation of hydrostratigraphic data for input to an updated groundwater flow model for the General Separations Area (GSA; Figure 1) at the Department of Energy’s (DOE) Savannah River Site (SRS). This report is one of several discrete but interrelated tasks that support development of an updated groundwater model (Bagwell and Flach, 2016).

  7. 41 CFR 102-75.1155 - May an acceptable gift of property be converted to money?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of property be converted to money? 102-75.1155 Section 102-75.1155 Public Contracts and Property...-75.1155 May an acceptable gift of property be converted to money? GSA can determine whether or not a gift of property can and should be converted to money. After conversion, GSA must deposit the funds...

  8. 78 FR 8145 - Sequence 24 Findings of the EISA 436(h) Ad-Hoc Review Group on Green Building Certification Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... Group are seeking public input regarding possible approaches GSA may take in fulfilling its requirement... comprehensive and environmentally- sound approach to the certification of green Federal buildings. GSA is using... comments by one of the methods shown below on or before 60 days after publication in the Federal Register...

  9. 41 CFR 102-34.135 - What do we do about a lost or stolen license plate?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34-MOTOR VEHICLE MANAGEMENT Identifying and Registering Motor Vehicles License Plates § 102-34.135 What do we do about a lost or stolen license plate? You must report the loss or theft of license plates...), local police, to GSA Fleet when a GSA Fleet leased motor vehicle is involved, and to the Federal...

  10. 41 CFR 102-118.590 - May my agency appeal a prepayment audit decision of the GSA Audit Division?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May my agency appeal a prepayment audit decision of the GSA Audit Division? 102-118.590 Section 102-118.590 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION...

  11. 41 CFR 102-118.335 - What does the GSA Audit Division consider when verifying an agency prepayment audit program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What does the GSA Audit Division consider when verifying an agency prepayment audit program? 102-118.335 Section 102-118.335 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118...

  12. 41 CFR 102-118.580 - May a TSP appeal a prepayment audit decision of the GSA Audit Division?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false May a TSP appeal a prepayment audit decision of the GSA Audit Division? 102-118.580 Section 102-118.580 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION...

  13. 41 CFR 102-41.215 - Do we report to GSA all forfeited, voluntarily abandoned, or unclaimed drug paraphernalia not...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Do we report to GSA all forfeited, voluntarily abandoned, or unclaimed drug paraphernalia not required for official use? 102-41.215 Section 102-41.215 Public Contracts and Property Management Federal Property Management Regulations System...

  14. 41 CFR 300-90.5 - What factors will GSA consider in approving a request for a telework travel test program?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... consider in approving a request for a telework travel test program? 300-90.5 Section 300-90.5 Public Contracts and Property Management Federal Travel Regulation System GENERAL AGENCY REQUIREMENTS 90-TELEWORK TRAVEL EXPENSES TEST PROGRAMS § 300-90.5 What factors will GSA consider in approving a request for a...

  15. Developing and Implementing Health and Sustainability Guidelines for Institutional Food Service123

    PubMed Central

    Kimmons, Joel; Jones, Sonya; McPeak, Holly H.; Bowden, Brian

    2012-01-01

    Health and sustainability guidelines for institutional food service are directed at improving dietary intake and increasing the ecological benefits of the food system. The development and implementation of institutional food service guidelines, such as the Health and Human Services (HHS) and General Services Administration (GSA) Health and Sustainability Guidelines for Federal Concessions and Vending Operations (HHS/GSA Guidelines), have the potential to improve the health and sustainability of the food system. Institutional guidelines assist staff, managers, and vendors in aligning the food environment at food service venues with healthier and more sustainable choices and practices. Guideline specifics and their effective implementation depend on the size, culture, nature, and management structure of an institution and the individuals affected. They may be applied anywhere food is sold, served, or consumed. Changing institutional food service practice requires comprehensive analysis, engagement, and education of all relevant stakeholders including institutional management, members of the food supply chain, and customers. Current examples of food service guidelines presented here are the HHS and GSA Health and Sustainability Guidelines for Federal Concessions and Vending Operations, which translate evidence-based recommendations on health and sustainability into institutional food service practices and are currently being implemented at the federal level. Developing and implementing guidelines has the potential to improve long-term population health outcomes while simultaneously benefitting the food system. Nutritionists, public health practitioners, and researchers should consider working with institutions to develop, implement, and evaluate food service guidelines for health and sustainability. PMID:22585909

  16. Developing and implementing health and sustainability guidelines for institutional food service.

    PubMed

    Kimmons, Joel; Jones, Sonya; McPeak, Holly H; Bowden, Brian

    2012-05-01

    Health and sustainability guidelines for institutional food service are directed at improving dietary intake and increasing the ecological benefits of the food system. The development and implementation of institutional food service guidelines, such as the Health and Human Services (HHS) and General Services Administration (GSA) Health and Sustainability Guidelines for Federal Concessions and Vending Operations (HHS/GSA Guidelines), have the potential to improve the health and sustainability of the food system. Institutional guidelines assist staff, managers, and vendors in aligning the food environment at food service venues with healthier and more sustainable choices and practices. Guideline specifics and their effective implementation depend on the size, culture, nature, and management structure of an institution and the individuals affected. They may be applied anywhere food is sold, served, or consumed. Changing institutional food service practice requires comprehensive analysis, engagement, and education of all relevant stakeholders including institutional management, members of the food supply chain, and customers. Current examples of food service guidelines presented here are the HHS and GSA Health and Sustainability Guidelines for Federal Concessions and Vending Operations, which translate evidence-based recommendations on health and sustainability into institutional food service practices and are currently being implemented at the federal level. Developing and implementing guidelines has the potential to improve long-term population health outcomes while simultaneously benefitting the food system. Nutritionists, public health practitioners, and researchers should consider working with institutions to develop, implement, and evaluate food service guidelines for health and sustainability.

  17. Comparison of Tc-99m GSA scintigraphy and CT volumetry for evaluation in portal vein embolization.

    PubMed

    Kono, Yumiko; Kariya, Shuji; Komemushi, Atsushi; Nakatani, Miyuki; Yoshida, Rie Yagi; Suzuki, Satoshi; Ha-Kawa, Sung Kil; Utsunomiya, Keita; Ueno, Yasuhiro; Satoi, Sohei; Kaibori, Masaki; Kon, Masanori; Tanigawa, Noboru

    2014-08-01

    To determine the correlation of the rate of change of each future remnant liver (FRL) before and after portal vein embolization (PVE), by CT volumetry and Tc-99m galactosyl human serum albumin scintigraphy (GSA scintigraphy). From December 2007 to July 2012, ten patients underwent PVE before hepatic resection. CT volumetry and GSA scintigraphy were performed before and after PVE. The FRL was divided at Cantlie's line for CT volumetry, and volume change rates before and after PVE were calculated. The maximum removal rate (Rmax) was calculated using a radiopharmacokinetic model in GSA scintigraphy. The FRL Rmax change rates before and after PVE were calculated. The correlation between the volume change rates and the Rmax change rates was analyzed. The FRL volume change rate was 1.28 ± 0.26 (mean ± SD); the FRL hypertrophied in all patients significantly (p = 0.005). The FRL Rmax change rate was 1.66 ± 0.75; excluding one patient, there was significant FRL Rmax increase (p = 0.022). Although both increased significantly, no correlation between the volume change rate and the Rmax change rate was observed. No correlation was observed between the FRL volume rate and the Rmax rate.

  18. 41 CFR 102-71.5 - What is the scope and philosophy of the General Services Administration's (GSA) real property...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What is the scope and philosophy of the General Services Administration's (GSA) real property policies? 102-71.5 Section 102-71.5...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 71-GENERAL § 102-71.5 What is the scope and philosophy of the...

  19. 41 CFR 102-71.5 - What is the scope and philosophy of the General Services Administration's (GSA) real property...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What is the scope and philosophy of the General Services Administration's (GSA) real property policies? 102-71.5 Section 102-71.5...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 71-GENERAL § 102-71.5 What is the scope and philosophy of the...

  20. 41 CFR 102-71.5 - What is the scope and philosophy of the General Services Administration's (GSA) real property...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What is the scope and philosophy of the General Services Administration's (GSA) real property policies? 102-71.5 Section 102-71.5...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 71-GENERAL § 102-71.5 What is the scope and philosophy of the...

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