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Sample records for shi exhibits reduced

  1. Thermally reduced graphenes exhibiting a close relationship to amorphous carbon

    NASA Astrophysics Data System (ADS)

    An Wong, Colin Hong; Ambrosi, Adriano; Pumera, Martin

    2012-07-01

    Graphene is an important material for sensing and energy storage applications. Since the vast majority of sensing and energy storage chemical and electrochemical systems require bulk quantities of graphene, thermally reduced graphene oxide (TRGO) is commonly employed instead of pristine graphene. The sp2 planar structure of TRGO is heavily damaged, consisting of a very short sp2 crystallite size of nanometre length and with areas of sp3 hybridized carbon. Such a structure of TRGO is reminiscent of the key characteristic of the structure of amorphous carbon, which is defined as a material without long-range crystalline order consisting of both sp2 and sp3 hybridized carbons. Herein, we describe the characterization of TRGO, its parent graphite material and carbon black (a form of amorphous carbon) via transmission electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and cyclic voltammetry experiments. We used the data obtained as well as consideration of practical factors to perform a comparative assessment of the relative electrochemical performances of TRGO against amorphous carbon. We found out that TRGO and amorphous carbon exhibit almost identical characteristics in terms of density of defects in the sp2 lattice and a similar crystallite size as determined by Raman spectroscopy. These two materials also exhibit similar amounts of oxygen containing groups as determined by XPS and nearly indistinguishable cyclic voltammetric response providing almost identical heterogeneous electron transfer constants. This leads us to conclude that for some sensing and energy storage electrochemical applications, the use of amorphous carbon might be a much more economical solution than the one requiring digestion of highly crystalline graphite with strong oxidants to graphite oxide and then thermally exfoliating it to thermally reduced graphene oxide.

  2. Hoxa10 null animals exhibit reduced platelet biogenesis

    PubMed Central

    Konieczna, Iwona M.; DeLuca, Teresa A.; Eklund, Elizabeth A.; Miller, William M.

    2016-01-01

    Summary The transcription factor HOXA10 is an important regulator of myelopoiesis. Engineered over-expression of Hoxa10 in mice results in a myeloproliferative disorder that progresses to acute myeloid leukaemia (AML) over time, and in humans over-expression is associated with poor outcomes in AML. Here, we report that loss of Hoxa10 expression in mice results in reduced platelet count and platelet production, but does not affect clotting efficiency. About 40% fewer platelets were found in Hoxa10 null animals in comparison to wild type littermates. We found a nearly 50% reduction in the percentage of reticulated platelets in Hoxa10 null mice, suggesting deficient platelet production. Furthermore, Hoxa10 null animals recovered less efficiently from induced thrombocytopenia, supporting our hypothesis of defective platelet production. This also correlated with reduced colony formation potential of stem and progenitor cells seeded in megakaryocyte-enhancing conditions in vitro. Together, our results indicate that HOXA10 is important for megakaryopoiesis and platelet biogenesis. PMID:26847476

  3. Method for reducing pressure drop through filters, and filter exhibiting reduced pressure drop

    DOEpatents

    Sappok, Alexander; Wong, Victor

    2014-11-18

    Methods for generating and applying coatings to filters with porous material in order to reduce large pressure drop increases as material accumulates in a filter, as well as the filter exhibiting reduced and/or more uniform pressure drop. The filter can be a diesel particulate trap for removing particulate matter such as soot from the exhaust of a diesel engine. Porous material such as ash is loaded on the surface of the substrate or filter walls, such as by coating, depositing, distributing or layering the porous material along the channel walls of the filter in an amount effective for minimizing or preventing depth filtration during use of the filter. Efficient filtration at acceptable flow rates is achieved.

  4. Men without a sense of smell exhibit a strongly reduced number of sexual relationships, women exhibit reduced partnership security - a reanalysis of previously published data.

    PubMed

    Croy, Ilona; Bojanowski, Viola; Hummel, Thomas

    2013-02-01

    Olfactory function influences social behavior. For instance, olfaction seems to play a key role in mate choice and helps detecting emotions in other people. In a previous study, we showed that people who were born without a sense of smell exhibit enhanced social insecurity. Based on the comments to this article we decided to have a closer look to whether the absence of the sense of smell affects men and women differently. Under this focus questionnaire data of 32 patients, diagnosed with isolated congenital anosmia (10 men, 22 women) and 36 age-matched healthy controls (15 men, 21 women) was reanalyzed. In result, men and women without a sense of smell reported enhanced social insecurity, but with different consequences: Men who were born without a sense of smell exhibit a strongly reduced number of sexual relationships and women are affected such that they feel less secure about their partner. This emphasizes the importance of the sense of smell for intimate relationships.

  5. Highly reduced double-decker single-molecule magnets exhibiting slow magnetic relaxation.

    PubMed

    Gonidec, Mathieu; Krivokapic, Itana; Vidal-Gancedo, Jose; Davies, E Stephen; McMaster, Jonathan; Gorun, Sergiu M; Veciana, Jaume

    2013-04-15

    F64Pc2Ln (1Ln, Ln = Tb or Lu) represent the first halogenated phthalocyanine double-decker lanthanide complexes, and 1Tb exhibits single-molecule magnet properties as revealed by solid-state magnetometry. The fluorine substituents of the phthalocyanine rings have a dramatic effect on the redox properties of the F64Pc2Ln complexes, namely, a stabilization of their reduced states. Electrochemical and spectroelectrochemical measurements demonstrate that the 1Tb(-/2-) and 1Tb(2-/3-) couples exhibit redox reversibility and that the 1Tb(-), 1Tb(2-) and 1Tb(3-) species may be prepared by bulk electrolysis in acetone. Low-temperature MCD studies reveal for the first time magnetization hystereses for the super-reduced dianionic and trianionic states of Pc2Ln.

  6. The Shy Child. ERIC Digest.

    ERIC Educational Resources Information Center

    Hyson, Marion C.; Van Trieste, Karen

    This ERIC digest: (1) describes types and manifestations of shyness among children; (2) briefly reviews research on genetic, temperamental, and environmental influences on shyness; (3) distinguishes between normal and problematic shyness; and (4) suggests ways for parents and teachers to help the shy child by accepting the whole child, building…

  7. Transposon-Derived Brucella abortus Rough Mutants Are Attenuated and Exhibit Reduced Intracellular Survival

    PubMed Central

    Allen, Chris A.; Adams, L. Garry; Ficht, Thomas A.

    1998-01-01

    The O antigen of Brucella abortus has been described as a major virulence determinant based on the attenuated survival of fortuitously isolated rough variants. However, the lack of genetic definition of these mutants and the virulence of naturally occurring rough species, Brucella ovis and Brucella canis, has confused interpretation. To better characterize the role of O antigen in virulence and survival, transposon mutagenesis was used to generate B. abortus rough mutants defective in O-antigen presentation. Sequence analysis of DNA flanking the site of Tn5 insertion was used to verify insertion in genes encoding lipopolysaccharide (LPS) biosynthetic functions. Not surprisingly, each of the rough mutants was attenuated for survival in mice, but unexpected differences among the mutants were observed. In an effort to define the basis for the observed differences, the structure of the rough LPS and the sensitivity of these mutants to individual killing mechanisms were examined in vitro. All of the B. abortus rough mutants exhibited a 4- to 5-log-unit increase, compared to the smooth parental strain, in sensitivity to complement-mediated lysis. Little change was evident in the sensitivity of these organisms to hydrogen peroxide, consistent with an inability of O antigen to exclude relatively small molecules. Sensitivity to polymyxin B, which was employed as a model cationic, amphipathic peptide similar to defensins found in phagocytic cells, revealed survival differences among the rough mutants similar to those observed in the mouse. One mutant in particular exhibited hypersensitivity to polymyxin B and reduced survival in mice. This mutant was characterized by a truncated rough LPS. DNA sequence analysis of this mutant revealed a transposon interruption in the gene encoding phosphomannomutase (pmm), suggesting that this activity may be required for the synthesis of a full-length core polysaccharide in addition to O antigen. B. abortus O antigen appears to be essential

  8. Children and Adolescents with Autism Exhibit Reduced MEG Steady-State Gamma Responses

    PubMed Central

    Wilson, Tony W.; Rojas, Donald C.; Reite, Martin L.; Teale, Peter D.; Rogers, Sally J.

    2009-01-01

    Background Recent neuroimaging studies of autism have indicated reduced functional connectivity during both cognitive tasks and rest. These data suggest long-range connectivity may be compromised in this disorder, and current neurological theories of autism contend disrupted inter-regional interactions may be an underlying mechanism explaining behavioral symptomatology. However, it is unclear whether deficient neuronal communication is attributable to fewer long-range tracts or more of a local deficit in neural circuitry. This study examines the integrity of local circuitry by focusing on gamma band activity in auditory cortices of children and adolescents with autism. Methods Ten children and adolescents with autism and 10 matched controls participated. Both groups listened to 500 ms duration monaural click trains with a 25 ms inter-click interval, as magnetoencephalography was acquired from the contralateral hemisphere. To estimate 40 Hz spectral power density, we performed time-frequency decomposition of the single-trial magnetic steady-state response data using complex demodulation. Results Children and adolescents with autism exhibited significantly reduced left hemispheric 40 Hz power from 200–500 ms post-stimulus onset. In contrast, no significant between group differences were observed for right hemispheric cortices. Conclusions The production and/or maintenance of left hemispheric gamma oscillations appeared abnormal in participants with autism. We interpret these data as indicating that in autism, particular brain regions may be unable to generate the high-frequency activity likely necessary for binding and other forms of inter-regional interactions. These findings augment connectivity theories of autism with novel evidence that aberrations in local circuitry could underlie putative deficiencies in long-range neural communication. PMID:16950225

  9. [Brief explanation of shi lin (urolithic stranguria)].

    PubMed

    Li, Yuan-yuan

    2010-05-01

    Shi lin (urolithic stranguria) is a kind of stranguria, manifested as pain occurred when pissing and sand-like in the urine, developed from the early concept of shi long. This name of disease was appeared firstly in Shen nong ben cao jing (Shennong's Classic of Materia Medica), and then, the disease name of sha lin, sha shi lin and sha lin were derived from it by the Song Dynasty. It was said that the disease with sha (sand-like) was easy to treat, and with shi (stone-like) was difficult to cure. This disease was also happened in the children, and the reasons were the same with ones of the adult. Furthermore, there was a name of disease, xue sha lin, which was a kind of woman disease and had nothing to do with shi lin.

  10. Women stereotypes in Shi Zhecun's short stories.

    PubMed

    Rosenmeier, Christopher

    2010-01-01

    This article analyses the representation of women in two 1933 short story collections by Shi Zhecun: An Evening of Spring Rain and Exemplary Conduct of Virtuous Women. It discusses how the New Woman image was a site of contestation in Republican China, and argues that Shi Zhecun’s short stories contain four basic stereotypes: the enigmatic woman, the estranged wife, the prostitute, and the inhibited woman. Using these narratives of women and how they were perceived by men, Shi Zhecun deconstructed the New Woman image by subverting the various ways modernity was projected onto women.

  11. Lift producing device exhibiting low drag and reduced ventilation potential and method for producing the same

    NASA Technical Reports Server (NTRS)

    Caldwell, Richard A. (Inventor)

    1991-01-01

    A lift producing device is disclosed which is adapted to be connected to a vehicle to provide lift to the vehicle when the vehicle is moved relative to a first fluid medium having a first density and viscosity and being in contact with a second fluid medium adjacent the vehicle. The second fluid medium has a second fluid density which is different from the first fluid density. The lift producing device comprises opposed first and second major surfaces joined at a longitudinally extending leading edge and at a longitudinally extending trailing edge, with at least a portion of the longitudinally extending leading edge being spaced from the longitudinally extending trailing edge by a predetermined mean chord length. When the vehicle is moved relative to the first fluid medium at a velocity within a range of predetermined velocities, with each of the velocities having a direction inclined from a plane extending through the leading edge and the trailing edge within a predetermined angular range, a region of high pressure is generated in the first fluid medium adjacent the first major surface and a region of low pressure is generated in the first fluid medium adjacent the second major surface. The lift producing device has a cross-sectional shape which will generate a pressure distribution around the device when the vehicle is moved relative to the first fluid medium at a velocity within the range of predetermined velocities such that the first fluid medium exhibits attached laminar flow along the device for a portion of the predetermined mean chord length from the leading edge to the trailing edge and will neither form a laminar separation bubble adjacent the second major surface of the device, nor exhibit turbulent separation adjacent the second major surface for substantially all of the predetermined mean chord length from the leading edge to the trailing edge. The portion along which attached laminar flow is maintained is the longest portion which will still fulfill

  12. Genetically Engineered Alginate Lyase-PEG Conjugates Exhibit Enhanced Catalytic Function and Reduced Immunoreactivity

    PubMed Central

    Lamppa, John W.; Ackerman, Margaret E.; Lai, Jennifer I.; Scanlon, Thomas C.; Griswold, Karl E.

    2011-01-01

    Alginate lyase enzymes represent prospective biotherapeutic agents for treating bacterial infections, particularly in the cystic fibrosis airway. To effectively deimmunize one therapeutic candidate while maintaining high level catalytic proficiency, a combined genetic engineering-PEGylation strategy was implemented. Rationally designed, site-specific PEGylation variants were constructed by orthogonal maleimide-thiol coupling chemistry. In contrast to random PEGylation of the enzyme by NHS-ester mediated chemistry, controlled mono-PEGylation of A1-III alginate lyase produced a conjugate that maintained wild type levels of activity towards a model substrate. Significantly, the PEGylated variant exhibited enhanced solution phase kinetics with bacterial alginate, the ultimate therapeutic target. The immunoreactivity of the PEGylated enzyme was compared to a wild type control using in vitro binding studies with both enzyme-specific antibodies, from immunized New Zealand white rabbits, and a single chain antibody library, derived from a human volunteer. In both cases, the PEGylated enzyme was found to be substantially less immunoreactive. Underscoring the enzyme's potential for practical utility, >90% of adherent, mucoid, Pseudomonas aeruginosa biofilms were removed from abiotic surfaces following a one hour treatment with the PEGylated variant, whereas the wild type enzyme removed only 75% of biofilms in parallel studies. In aggregate, these results demonstrate that site-specific mono-PEGylation of genetically engineered A1-III alginate lyase yielded an enzyme with enhanced performance relative to therapeutically relevant metrics. PMID:21340021

  13. Patients with Chronic Spinal Cord Injury Exhibit Reduced Autonomic Modulation during an Emotion Recognition Task

    PubMed Central

    Varas-Díaz, Gonzalo; Brunetti, Enzo P.; Rivera-Lillo, Gonzalo; Maldonado, Pedro E.

    2017-01-01

    Spinal cord injury (SCI) is a devastating event for individuals, who frequently develop motor and sensory impairment as well as autonomic dysfunction. Previous studies reported that autonomic activity plays a major role in social cognition and that difficulties in the ability to interpret social information are commonly observed in a variety of mental disorders, which in turn correlate with a poor autonomic nervous system (ANS) regulation. It is well established that subjects with SCI have an alteration in ANS regulation mechanisms. We hypothesized that subjects diagnosed with SCI, who are experiencing a period of adaptation and socio-labor insertion suffer alterations in an emotion recognition task, a component of social cognition, which correlate with poor ANS regulation. We evaluated ANS function by measuring the heart rate variability (HRV) in 18 healthy subjects and 10 subjects with SCI. A 5-min baseline HRV was compared to a task period while performing The reading the mind in the eyes test (RMET). We found that while both groups have similar general performance in the test, healthy subjects responded with greater certainty during the RMET. This level of certainty during the RMET was positively correlated with baseline HRV measures in this group. Also, the group of healthy subjects exhibited higher HRV at baseline than participants with SCI. Finally, the changes in HRV between baseline and task condition were significantly higher in healthy individuals than in SCI participants. Our results show that patients with SCI have low levels of autonomic regulation mechanisms which may promote social cognition problems during their reinsertion to daily life. PMID:28228721

  14. Patients with Chronic Spinal Cord Injury Exhibit Reduced Autonomic Modulation during an Emotion Recognition Task.

    PubMed

    Varas-Díaz, Gonzalo; Brunetti, Enzo P; Rivera-Lillo, Gonzalo; Maldonado, Pedro E

    2017-01-01

    Spinal cord injury (SCI) is a devastating event for individuals, who frequently develop motor and sensory impairment as well as autonomic dysfunction. Previous studies reported that autonomic activity plays a major role in social cognition and that difficulties in the ability to interpret social information are commonly observed in a variety of mental disorders, which in turn correlate with a poor autonomic nervous system (ANS) regulation. It is well established that subjects with SCI have an alteration in ANS regulation mechanisms. We hypothesized that subjects diagnosed with SCI, who are experiencing a period of adaptation and socio-labor insertion suffer alterations in an emotion recognition task, a component of social cognition, which correlate with poor ANS regulation. We evaluated ANS function by measuring the heart rate variability (HRV) in 18 healthy subjects and 10 subjects with SCI. A 5-min baseline HRV was compared to a task period while performing The reading the mind in the eyes test (RMET). We found that while both groups have similar general performance in the test, healthy subjects responded with greater certainty during the RMET. This level of certainty during the RMET was positively correlated with baseline HRV measures in this group. Also, the group of healthy subjects exhibited higher HRV at baseline than participants with SCI. Finally, the changes in HRV between baseline and task condition were significantly higher in healthy individuals than in SCI participants. Our results show that patients with SCI have low levels of autonomic regulation mechanisms which may promote social cognition problems during their reinsertion to daily life.

  15. Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning.

    PubMed

    Silberhorn, Elisabeth; Schwartz, Uwe; Löffler, Patrick; Schmitz, Samuel; Symelka, Anne; de Koning-Ward, Tania; Merkl, Rainer; Längst, Gernot

    2016-12-01

    The packaging and organization of genomic DNA into chromatin represents an additional regulatory layer of gene expression, with specific nucleosome positions that restrict the accessibility of regulatory DNA elements. The mechanisms that position nucleosomes in vivo are thought to depend on the biophysical properties of the histones, sequence patterns, like phased di-nucleotide repeats and the architecture of the histone octamer that folds DNA in 1.65 tight turns. Comparative studies of human and P. falciparum histones reveal that the latter have a strongly reduced ability to recognize internal sequence dependent nucleosome positioning signals. In contrast, the nucleosomes are positioned by AT-repeat sequences flanking nucleosomes in vivo and in vitro. Further, the strong sequence variations in the plasmodium histones, compared to other mammalian histones, do not present adaptations to its AT-rich genome. Human and parasite histones bind with higher affinity to GC-rich DNA and with lower affinity to AT-rich DNA. However, the plasmodium nucleosomes are overall less stable, with increased temperature induced mobility, decreased salt stability of the histones H2A and H2B and considerable reduced binding affinity to GC-rich DNA, as compared with the human nucleosomes. In addition, we show that plasmodium histone octamers form the shortest known nucleosome repeat length (155bp) in vitro and in vivo. Our data suggest that the biochemical properties of the parasite histones are distinct from the typical characteristics of other eukaryotic histones and these properties reflect the increased accessibility of the P. falciparum genome.

  16. Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning

    PubMed Central

    Silberhorn, Elisabeth; Schwartz, Uwe; Symelka, Anne; de Koning-Ward, Tania; Längst, Gernot

    2016-01-01

    The packaging and organization of genomic DNA into chromatin represents an additional regulatory layer of gene expression, with specific nucleosome positions that restrict the accessibility of regulatory DNA elements. The mechanisms that position nucleosomes in vivo are thought to depend on the biophysical properties of the histones, sequence patterns, like phased di-nucleotide repeats and the architecture of the histone octamer that folds DNA in 1.65 tight turns. Comparative studies of human and P. falciparum histones reveal that the latter have a strongly reduced ability to recognize internal sequence dependent nucleosome positioning signals. In contrast, the nucleosomes are positioned by AT-repeat sequences flanking nucleosomes in vivo and in vitro. Further, the strong sequence variations in the plasmodium histones, compared to other mammalian histones, do not present adaptations to its AT-rich genome. Human and parasite histones bind with higher affinity to GC-rich DNA and with lower affinity to AT-rich DNA. However, the plasmodium nucleosomes are overall less stable, with increased temperature induced mobility, decreased salt stability of the histones H2A and H2B and considerable reduced binding affinity to GC-rich DNA, as compared with the human nucleosomes. In addition, we show that plasmodium histone octamers form the shortest known nucleosome repeat length (155bp) in vitro and in vivo. Our data suggest that the biochemical properties of the parasite histones are distinct from the typical characteristics of other eukaryotic histones and these properties reflect the increased accessibility of the P. falciparum genome. PMID:28033404

  17. Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity

    PubMed Central

    2015-01-01

    Multifunctional metal chelators that can modulate the amyloid β (Aβ) peptide aggregation and its interaction with metal ions such as copper and zinc hold considerable promise as therapeutic agents for Alzheimer’s disease (AD). However, specific rather than systemic metal chelation by these compounds is needed in order to limit any side effects. Reported herein are two novel small bifunctional chelators, 2-[2-hydroxy-4-(diethylamino)phenyl]benzothiazole (L1) and 2-(2-hydroxy-3-methoxyphenyl)benzothiazole (L2), in which the metal-binding donor atoms are integrated within a molecular framework derived from the amyloid-binding fluorescent dye thioflavin T (ThT). The metal-binding properties of L1 and L2 were probed by pH spectrophotometric titrations to determine their pKa values and the corresponding metal complex stability constants, and the isolated metal complexes were structurally characterized. The amyloid-fibril-binding properties of L1 and L2 were investigated by fluorescence titrations and ThT competition assays. Interestingly, L1 and L2 do not lead to the formation of neurotoxic Aβ42 oligomers in the presence or absence of metal ions, as observed by native gel electrophoresis, Western blotting, and transmission electron microscopy. In addition, L1 and L2 were able to reduce the cell toxicity of preformed Aβ42 oligomers and of the copper-stabilized Aβ42 oligomers. Given their ability to reduce the toxicity of soluble Aβ42 and Cu-Aβ42 species, L1 and L2 are promising lead compounds for the development of chemical agents that can control the neurotoxicity of soluble Aβ42 species in AD. PMID:25333939

  18. Commercial Seed Lots Exhibit Reduced Seed Dormancy in Comparison to Wild Seed Lots of Echinacea purpurea

    PubMed Central

    Qu, Luping; Wang, Xiping; Chen, Ying; Scalzo, Richard; Widrlechner, Mark P.; Davis, Jeanine M.; Hancock, James F.

    2005-01-01

    Seed germination patterns were studied in E. purpurea (L.) Moench grouped by seed source, one group of seven lots from commercially cultivated populations and a second group of nine lots regenerated from ex situ conserved wild populations. Germination tests were conducted in a growth chamber in light (40 μmol·m−2·s−1) or darkness at 25 °C for 20 days after soaking the seeds in water for 10 minutes. Except for two seed lots from wild populations, better germination was observed for commercially cultivated populations in light (90% mean among seed lots, ranging from 82% to 95%) and in darkness (88% mean among seed lots, ranging from 82% to 97%) than for wild populations in light (56% mean among seed lots, ranging from 9% to 92%) or in darkness (37% mean among seed lots, ranging from 4% to 78%). No germination difference was measured between treatments in light and darkness in the commercially cultivated populations, but significant differences were noted for treatments among wild populations. These results suggest that repeated cycles of sowing seeds during cultivation without treatments for dormancy release resulted in reduced seed dormancy in E. purpurea. PMID:16429595

  19. The MOSS Physcomitrella patens reproductive organ development is highly organized, affected by the two SHI/STY genes and by the level of active auxin in the SHI/STY expression domain.

    PubMed

    Landberg, Katarina; Pederson, Eric R A; Viaene, Tom; Bozorg, Behruz; Friml, Jirí; Jönsson, Henrik; Thelander, Mattias; Sundberg, Eva

    2013-07-01

    In order to establish a reference for analysis of the function of auxin and the auxin biosynthesis regulators SHORT INTERNODE/STYLISH (SHI/STY) during Physcomitrella patens reproductive development, we have described male (antheridial) and female(archegonial) development in detail, including temporal and positional information of organ initiation. This has allowed us to define discrete stages of organ morphogenesis and to show that reproductive organ development in P. patens is highly organized and that organ phyllotaxis differs between vegetative and reproductive development. Using the PpSHI1 and PpSHI2 reporter and knockout lines, the auxin reporters GmGH3(pro):GUS and PpPINA(pro):GFP-GUS, and the auxin-conjugating transgene PpSHI2(pro):IAAL, we could show that the PpSHI genes, and by inference also auxin, play important roles for reproductive organ development in moss. The PpSHI genes are required for the apical opening of the reproductive organs, the final differentiation of the egg cell, and the progression of canal cells into a cell death program. The apical cells of the archegonium, the canal cells, and the egg cell are also sites of auxin responsiveness and are affected by reduced levels of active auxin, suggesting that auxin mediates PpSHI function in the reproductive organs.

  20. Brain Electrical Activity of Shy and Non-Shy Preschool-Aged Children during Executive Function Tasks

    PubMed Central

    Wolfe, Christy D.; Bell, Martha Ann

    2014-01-01

    Psychophysiological and cognitive performance differences exist between shy and non-shy individuals. Neuroimaging studies have shown identifiable differences in task-related cortical functioning between adults with and without sensitivity to social events. The current study compared baseline and task measures of EEG power (6–9 Hz) for 125 shy and non-shy children between the ages of 41–55 months who differed in core executive function (EF) skills. Results indicated an increase in medial frontal EEG power from baseline-to-task for high EF performers (shy and non-shy). Shy/low EF performers also demonstrated this increase, but the non-shy/low EF group did not. For the medial parietal region, only the shy children (high and low EF performers) showed an increase in power from baseline-to-task; and for the shy/high EF group, left hemisphere power was greater than the right during baseline and task. This study is believed to be the first continuous-recording EEG comparison between children who are shy and non-shy in the context of an EF assessment. These findings highlight differences in medial frontal and medial parietal power for children who differ in shyness and EF skills. They also suggest the value of future research examining strong EF skills as protective and regulatory for shy children. PMID:24944544

  1. Reward and punishment sensitivity in shy and non-shy adults

    PubMed Central

    Hardin, Michael G.; Perez-Edgar, Koraly; Guyer, Amanda E.; Pine, Daniel S.; Fox, Nathan A.; Ernst, Monique

    2009-01-01

    Few studies have examined underlying mechanisms linking social behavior, motivated behavior, and reward and punishment systems. The current study was designed to investigate these mechanisms by examining responses to both rewarding and punishing non-social stimuli in shy and non-shy adults. Ninety-three participants, comprising three social behavior groups (Shy, Non-shy, Control) completed the Monetary Incentive Delay task. Consistent with previous research, all participants were sensitive to incentive manipulations. There were also significant individual differences in response. Non-shy participants demonstrated sensitivity to both reward and punishment stimuli, and behavior indicative of high levels of arousal in approach motivation. Shy individuals demonstrated a large discrepancy in sensitivity to reward compared to punishment, with this discrepancy being driven by enhanced sensitivity to reward. Their behavior suggested conflict generated by increased arousal in both approach and withdrawal motivation systems. Current findings contribute to theoretical accounts of relations between social behavior and behavior modulated by reward and punishment. These findings carry implications for the study of psychopathology and neuroimaging research designed to examine relationships between social behavior, motivated behavior, and underlying reward and punishment systems. PMID:19718273

  2. Dark matter at the SHiP experiment

    NASA Astrophysics Data System (ADS)

    Timiryasov, Inar

    2016-10-01

    We study prospects of dark matter searches in the SHiP experiment. SHiP (Search for Hidden Particles) is the recently proposed fixed target experiment which will exploit the high-intensity beam of 400 GeV protons from the CERN SPS. In addition to the hidden sector detector, SHiP will be equipped with the ντ detector, which presumably would be sensitive to dark matter particles. We describe appropriate production and detection channels and estimate SHiP's sensitivity for a scalar dark matter coupled to the Standard model through the vector mediator.

  3. Candida species from oral cavity of HIV-infected children exhibit reduced virulence factors in the HAART era.

    PubMed

    Portela, Maristela Barbosa; Lima de Amorim, Elaine; Santos, Adrielle Mangabeira; Alexandre da Rocha Curvelo, José; de Oliveira Martins, Karol; Capillé, Cauli Lima; Maria de Araújo Soares, Rosangela; Barbosa de Araújo Castro, Gloria Fernanda

    2017-01-01

    This study aimed to assess, in vitro, the biofilm viability and the phospholipase and protease production of Candida spp. from the saliva of HIV infected children and healthy controls, and to correlate the results with the use of medical data. A total of 79 isolates were analyzed: 48 Candida albicans isolates (33/15) and 20 Candida parapsilosis sensu lato complex isolates (12/8) (from HIV/control patients, respectively), and 8 Candida krusei, 1 Candida tropicalis, 1 Candida dubliniensis and 1 Candida guilliermondii from HIV patients. The XTT (2, 3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-Carboxanilide) reduction assay analyzed the biofilm viability. Phospholipase and protease assays were performed using the egg yolk and Bovine Serum Albumin agar plate methods, respectively. All isolates were able to form biofilm with cell viability. Quantitatively, Candida isolates from both groups presented a similar ability to form biofilm (p > 0.05). The biofilm viability activity was higher in C. albicans isolates than in non-albicans Candida isolates (p < 0.05) for both groups. Phospholipase activity was detected in 32 isolates (40.5%) and it was significantly higher in the HIV group (p = 0.006). Protease activity was detected in 66 isolates (84.8%) and most of them were relatively/very strong producers. No statistical association with medical data was found in the HIV group. Although Candida spp. isolates from HIV-positive children presented higher phospholipase production, in vitro they exhibited reduced virulence factors compared to isolates from healthy individuals. This finding may enlighten the role played by immunosuppression in the modulation of Candida virulence attributes.

  4. Narrative Performance and Parental Scaffolding of Shy and Nonshy Children

    ERIC Educational Resources Information Center

    Reynolds, Kailey Pearl; Evans, Mary Ann

    2009-01-01

    This study examined differences in performance between 20 shy and 20 matched nonshy children on a narrative task and in the way parents scaffolded their narrative performance when reading the wordless book "Frog, Where Are You", by Mercer Mayer. Consistent with previous research, results demonstrated that shy children spoke less than their nonshy…

  5. Museum Exhibit

    NASA Technical Reports Server (NTRS)

    1991-01-01

    A TSP from NASA Tech Briefs provided the solution to an electrical problem at a Florida museum. When a model train would not start without a jerk, a Marshall Space Flight Center development called pulse width control was adapted. The new circuit enables the train to start smoothly and reduces construction and maintenance costs. The same technology is also used in another hands-on exhibit. Applications of other TSPs are anticipated.

  6. Optical amplifier exhibiting net phase-mismatch selected to at least partially reduce gain-induced phase-matching during operation and method of operation

    SciTech Connect

    Feve, Jean-Philippe; Kliner, Dahv A. V.; Farrow; Roger L.

    2011-02-01

    An optical amplifier, such as an optical waveguide amplifier (e.g., an optical fiber amplifier or a planar waveguide) or a non-guiding optical amplifier, that exhibits a net phase-mismatch selected to at least partially reduce gain-induced phase-matching during operation thereof is disclosed. In one aspect of the invention, an optical amplifier structure includes at least one optical amplifier having a length and a gain region. The at least one optical amplifier exhibits a net phase-mismatch that varies along at least part of the length thereof selected to at least partially reduce gain-induced phase-matching during operation thereof.

  7. CYP26A1 knockout embryonic stem cells exhibit reduced differentiation and growth arrest in response to retinoic acid.

    PubMed

    Langton, Simne; Gudas, Lorraine J

    2008-03-15

    CYP26A1, a cytochrome P450 enzyme, metabolizes all-trans-retinoic acid (RA) into polar metabolites, e.g. 4-oxo-RA and 4-OH-RA. To determine if altering RA metabolism affects embryonic stem (ES) cell differentiation, we disrupted both alleles of Cyp26a1 by homologous recombination. CYP26a1(-/-) ES cells had a 11.0+/-3.2-fold higher intracellular RA concentration than Wt ES cells after RA treatment for 48 h. RA-treated CYP26A1(-/-) ES cells exhibited 2-3 fold higher mRNA levels of Hoxa1, a primary RA target gene, than Wt ES cells. Despite increased intracellular RA levels, CYP26a1(-/-) ES cells were more resistant than Wt ES cells to RA-induced proliferation arrest. Transcripts for parietal endodermal differentiation markers, including laminin, J6(Hsp 47), and J31(SPARC, osteonectin) were expressed at lower levels in RA-treated CYP26a1(-/-) ES cells, indicating that the lack of CYP26A1 activity inhibits RA-associated differentiation. Microarray analyses revealed that RA-treated CYP26A1(-/-) ES cells exhibited lower mRNA levels than Wt ES cells for genes involved in differentiation, particularly in neural (Epha4, Pmp22, Nrp1, Gap43, Ndn) and smooth muscle differentiation (Madh3, Nrp1, Tagln Calponin, Caldesmon1). In contrast, genes involved in the stress response (e.g. Tlr2, Stk2, Fcgr2b, Bnip3, Pdk1) were expressed at higher levels in CYP26A1(-/-) than in Wt ES cells without RA. Collectively, our results show that CYP26A1 activity regulates intracellular RA levels, cell proliferation, transcriptional regulation of primary RA target genes, and ES cell differentiation to parietal endoderm.

  8. Proven practices for reducing aggressive and noncompliant behaviors exhibited by young children at home and at school.

    PubMed

    Vanderheyden, A; Witt, J C

    2000-10-01

    One of the single most powerful predictors of aggressive and noncompliant behaviors exhibited in early childhood is coercive parent-child interaction. Coercive parent-child interaction has been linked to multiple negative outcomes in the lives of children. When children learn to relate to their parents and the world in the context of coercive interaction, they are likely to experience significant deficits in the prosocial skills critical to school success. These children are much more likely to experience school failure and teacher and peer rejection. Further, when noncompliant and aggressive children enter school, they are most frequently exposed to a series of ineffective and increasingly restrictive treatments. Proven strategies exist to teach parents and children prosocial ways of interacting and to address these problems in the classroom, but in many cases these types of services are not easily accessible or routinely available. This paper makes recommendations for identifying effective, proven treatment strategies when practitioners observe coercive parent-child interaction or child noncompliance and aggression.

  9. The SHiP project at CERN

    NASA Astrophysics Data System (ADS)

    De Lellis, G.; SHiP Collaboration

    2016-07-01

    The discovery of the Higgs boson has fully confirmed the Standard Model of particles and fields. Nevertheless, there are still fundamental phenomena, like the existence of dark matter and the baryon asymmetry, which deserve an explanation that could come from the discovery of new particles. Searches for new physics with accelerators are performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. A new experimental facility at CERN meant to search for very weakly coupled particles in the few GeV mass domain has been recently proposed. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored. A beam dump facility using 400 GeV protons is a copious factory of charmed hadrons and could be used to probe the existence of such particles. The beam dump is also a copious source of neutrinos and in particular it is an ideal source of tau neutrinos, the less known particle in the Standard Model. Indeed, tau anti-neutrinos have not been directly observed so far. We report the physics potential of such an experiment. Resistive Plate Chambers could play a role in the SHiP detector.

  10. Do juveniles of the estuarine-dependent dusky kob, Argyrosomus japonicus, exhibit optimum growth indices at reduced salinities?

    NASA Astrophysics Data System (ADS)

    Bernatzeder, Andrea K.; Cowley, Paul D.; Hecht, Thomas

    2010-12-01

    The natural distribution of early juvenile (<150 mm TL) dusky kob Argyrosomus japonicus (Sciaenidae) along the east coast of South Africa appears to be restricted to the reduced salinity upper reaches of estuaries. This study experimentally tested the effect of salinity on growth indices in an attempt to explain the estuarine distribution of early juvenile A. japonicus. Growth under laboratory conditions was used as an indicator of relative energy expenditure for osmoregulation at salinities 5 (hypoosmotic), 12 (isosmotic) and 35 (hyperosmotic), as energy used for osmoregulation becomes unavailable for growth. Juveniles (81 ± 1.5 mm SL and 9.6 ± 0.5 g) survived and grew at all three salinities over a nine-week period. Contrary to what was hypothesised, growth of juveniles increased with increasing salinity (average weight 35.57 ± 1.50 g, 42.31 ± 2.70 g and 48.86 ± 1.30 g for the 5, 12 and 35 treatments respectively), with specific growth rate of juveniles at the hypoosmotic salinity (2.05 ± 0.15) significantly lower than at isosmotic (2.52 ± 0.09) and hyperosmotic salinities (2.59 ± 0.09). Food conversion ratio was significantly higher at the hypoosmotic (1.30 ± 0.28) than the hyperosmotic salinity (0.94 ± 0.05), but there was no difference between the isosmotic (1.01 ± 0.08) and hyperosmotic salinity. Salinity did not affect condition factor (range: 2.67 ± 0.03-2.75 ± 0.10) or feed intake (range: 2.43 ± 0.17-2.75 ± 0.53). The results, in part, indicated that early juvenile A. japonicus expend more energy at salinities below isosmotic levels and that salinity alone does not explain their natural distribution within estuaries. It is possible that high conductivity in the upper reaches of certain South African estuaries may mitigate the negative effect of reduced salinity on growth and hence the estuarine distribution of early juveniles.

  11. Control of dynamic foot-ground interactions in male and female soccer athletes: females exhibit reduced dexterity and higher limb stiffness during landing.

    PubMed

    Lyle, Mark A; Valero-Cuevas, Francisco J; Gregor, Robert J; Powers, Christopher M

    2014-01-22

    Controlling dynamic interactions between the lower limb and ground is important for skilled locomotion and may influence injury risk in athletes. It is well known that female athletes sustain anterior cruciate ligament (ACL) tears at higher rates than male athletes, and exhibit lower extremity biomechanics thought to increase injury risk during sport maneuvers. The purpose of this study was to examine whether lower extremity dexterity (LED)--the ability to dynamically control endpoint force magnitude and direction as quantified by compressing an unstable spring with the lower limb at submaximal forces--is a potential contributing factor to the "at-risk" movement behavior exhibited by female athletes. We tested this hypothesis by comparing LED-test performance and single-limb drop jump biomechanics between 14 female and 14 male high school soccer players. We found that female athletes exhibited reduced LED-test performance (p=0.001) and higher limb stiffness during landing (p=0.008) calculated on average within 51 ms of foot contact. Females also exhibited higher coactivation at the ankle (p=0.001) and knee (p=0.02) before landing. No sex differences in sagittal plane joint angles and center of mass velocity at foot contact were observed. Collectively, our results raise the possibility that the higher leg stiffness observed in females during landing is an anticipatory behavior due in part to reduced lower extremity dexterity. The reduced lower extremity dexterity and compensatory stiffening strategy may contribute to the heightened risk of ACL injury in this population.

  12. Control of dynamic foot-ground interactions in male and female soccer athletes: Females exhibit reduced dexterity and higher limb stiffness during landing

    PubMed Central

    Lyle, Mark A.; Valero-Cuevas, Francisco J.; Gregor, Robert J.; Powers, Christopher M.

    2014-01-01

    Controlling dynamic interactions between the lower limb and ground is important for skilled locomotion and may influence injury risk in athletes. It is well known that female athletes sustain anterior cruciate ligament (ACL) tears at higher rates than male athletes, and exhibit lower extremity biomechanics thought to increase injury risk during sport maneuvers. The purpose of this study was to examine whether lower extremity dexterity (LED) – the ability to dynamically control endpoint force magnitude and direction as quantified by compressing an unstable spring with the lower limb at submaximal forces – is a potential contributing factor to the “at-risk” movement behavior exhibited by female athletes. We tested this hypothesis by comparing LED-test performance and single-limb drop jump biomechanics between 14 female and 14 male high school soccer players. We found that female athletes exhibited reduced LED-test performance (p=0.001) and higher limb stiffness during landing (p=0.008) calculated on average within 51 ms of foot contact. Females also exhibited higher coactivation at the ankle (p=0.001) and knee (p=0.02) before landing. No sex differences in sagittal plane joint angles and center of mass velocity at foot contact were observed. Collectively, our results raise the possibility that the higher leg stiffness observed in females during landing is an anticipatory behavior due in part to reduced lower extremity dexterity. The reduced lower extremity dexterity and compensatory stiffening strategy may contribute to the heightened risk of ACL injury in this population. PMID:24275440

  13. Homologues of the Arabidopsis thaliana SHI/STY/LRP1 genes control auxin biosynthesis and affect growth and development in the moss Physcomitrella patens.

    PubMed

    Eklund, D Magnus; Thelander, Mattias; Landberg, Katarina; Ståldal, Veronika; Nilsson, Anders; Johansson, Monika; Valsecchi, Isabel; Pederson, Eric R A; Kowalczyk, Mariusz; Ljung, Karin; Ronne, Hans; Sundberg, Eva

    2010-04-01

    The plant hormone auxin plays fundamental roles in vascular plants. Although exogenous auxin also stimulates developmental transitions and growth in non-vascular plants, the effects of manipulating endogenous auxin levels have thus far not been reported. Here, we have altered the levels and sites of auxin production and accumulation in the moss Physcomitrella patens by changing the expression level of homologues of the Arabidopsis SHI/STY family proteins, which are positive regulators of auxin biosynthesis genes. Constitutive expression of PpSHI1 resulted in elevated auxin levels, increased and ectopic expression of the auxin response reporter GmGH3pro:GUS, and in an increased caulonema/chloronema ratio, an effect also induced by exogenous auxin application. In addition, we observed premature ageing and necrosis in cells ectopically expressing PpSHI1. Knockout of either of the two PpSHI genes resulted in reduced auxin levels and auxin biosynthesis rates in leafy shoots, reduced internode elongation, delayed ageing, a decreased caulonema/chloronema ratio and an increased number of axillary hairs, which constitute potential auxin biosynthesis sites. Some of the identified auxin functions appear to be analogous in vascular and non-vascular plants. Furthermore, the spatiotemporal expression of the PpSHI genes and GmGH3pro:GUS strongly overlap, suggesting that local auxin biosynthesis is important for the regulation of auxin peak formation in non-vascular plants.

  14. Exhibiting Lives

    ERIC Educational Resources Information Center

    Golden, Deborah; Elbaz-Luwisch, Freema

    2007-01-01

    This paper examines some of the dilemmas that accompany the emergence of the personal voice in scholarly work, by taking a close, grounded look at the way in which these unfolded in a specific academic course. As part of the course, entitled "A cultural approach to the life cycle", students were asked to participate in a group exhibition in which…

  15. Listeria monocytogenes strains selected on ciprofloxacin or the disinfectant benzalkonium chloride exhibit reduced susceptibility to ciprofloxacin, gentamicin, benzalkonium chloride, and other toxic compounds.

    PubMed

    Rakic-Martinez, Mira; Drevets, Douglas A; Dutta, Vikrant; Katic, Vera; Kathariou, Sophia

    2011-12-01

    Listeria monocytogenes is a leading agent for severe food-borne illness and death in the United States and other nations. Even though drug resistance has not yet threatened therapeutic interventions for listeriosis, selective pressure associated with exposure to antibiotics and disinfectants may result in reduced susceptibility to these agents. In this study, selection of several L. monocytogenes strains on either ciprofloxacin (2 μg/ml) or the quaternary ammonium disinfectant benzalkonium chloride (BC; 10 μg/ml) led to derivatives with increased MICs not only to these agents but also to several other toxic compounds, including gentamicin, the dye ethidium bromide, and the chemotherapeutic drug tetraphenylphosphonium chloride. The spectrum of compounds to which these derivatives exhibited reduced susceptibility was the same regardless of whether they were selected on ciprofloxacin or on BC. Inclusion of strains harboring the large plasmid pLM80 revealed that MICs to ciprofloxacin and gentamicin did not differ between the parental and plasmid-cured strains. However, ciprofloxacin-selected derivatives of pLM80-harboring strains had higher MICs than those derived from the plasmid-cured strains. Susceptibility to the antimicrobials was partially restored in the presence of the potent efflux inhibitor reserpine. Taken together, these data suggest that mutations in efflux systems are responsible for the multidrug resistance phenotype of strains selected on ciprofloxacin or BC.

  16. Listeria monocytogenes Strains Selected on Ciprofloxacin or the Disinfectant Benzalkonium Chloride Exhibit Reduced Susceptibility to Ciprofloxacin, Gentamicin, Benzalkonium Chloride, and Other Toxic Compounds▿

    PubMed Central

    Rakic-Martinez, Mira; Drevets, Douglas A.; Dutta, Vikrant; Katic, Vera; Kathariou, Sophia

    2011-01-01

    Listeria monocytogenes is a leading agent for severe food-borne illness and death in the United States and other nations. Even though drug resistance has not yet threatened therapeutic interventions for listeriosis, selective pressure associated with exposure to antibiotics and disinfectants may result in reduced susceptibility to these agents. In this study, selection of several L. monocytogenes strains on either ciprofloxacin (2 μg/ml) or the quaternary ammonium disinfectant benzalkonium chloride (BC; 10 μg/ml) led to derivatives with increased MICs not only to these agents but also to several other toxic compounds, including gentamicin, the dye ethidium bromide, and the chemotherapeutic drug tetraphenylphosphonium chloride. The spectrum of compounds to which these derivatives exhibited reduced susceptibility was the same regardless of whether they were selected on ciprofloxacin or on BC. Inclusion of strains harboring the large plasmid pLM80 revealed that MICs to ciprofloxacin and gentamicin did not differ between the parental and plasmid-cured strains. However, ciprofloxacin-selected derivatives of pLM80-harboring strains had higher MICs than those derived from the plasmid-cured strains. Susceptibility to the antimicrobials was partially restored in the presence of the potent efflux inhibitor reserpine. Taken together, these data suggest that mutations in efflux systems are responsible for the multidrug resistance phenotype of strains selected on ciprofloxacin or BC. PMID:22003016

  17. [Doctor HUANG Shi-ping's acupuncture with golden needles].

    PubMed

    Chen, Teng-Fei; Ma, Zeng-Bin; Xin, Si-Yuan; Zhu, Jiang

    2013-08-01

    Taking Doctor HUANG Shi-ping as the representative, the school of Huang's golden needle is based on Chinese martial art. Golden needles are adopted as main tool. Attaching great importance on the combination of acupuncture and moxibustioin, it is also characterized with penetrating needling with long needles. Through the development of three generations, it once outshone other schools in the field of acupuncture, and became famous all over the world. It made great contribution to the development of the course of acupuncture. However, with the development of the history, the form of acupuncture education as well as apparatus were all undergone an unified reform. Therefore, Doctor HUANG Shi-ping's acupuncture school be lost gradually.

  18. [Study on Shi Zhenduo's Ben cao bu (Supplemented materia medica)].

    PubMed

    Zhen, Xueyan; Zheng, Jinsheng

    2002-10-01

    Being called "precursor of pharmacy imported from the west" by Fan Xingzhun, a famous medical historian, Ben cao bu was lost in China. It has been found outside China recently. This article deals with the author, blockprinting edition, contents of the book and makes a comparison with its texts cited in Ben cao gang mu shi yi (Supplemented Compendium of Materia Medica). It also evaluates the practical significance of this book as an early dissemination of pharmacy imported from the west.

  19. A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence.

    PubMed

    Shoen, Carolyn M; DeStefano, Michelle S; Hager, Cynthia C; Tham, Kyi-Toe; Braunstein, Miriam; Allen, Alexandria D; Gates, Hiriam O; Cynamon, Michael H; Kernodle, Douglas S

    2013-01-11

    Early attempts to improve BCG have focused on increasing the expression of prominent antigens and adding recombinant toxins or cytokines to influence antigen presentation. One such modified BCG vaccine candidate has been withdrawn from human clinical trials due to adverse effects. BCG was derived from virulent Mycobacterium bovis and retains much of its capacity for suppressing host immune responses. Accordingly, we have used a different strategy for improving BCG based on reducing its immune suppressive capacity. We made four modifications to BCG Tice to produce 4dBCG and compared it to the parent vaccine in C57Bl/6 mice. The modifications included elimination of the oxidative stress sigma factor SigH, elimination of the SecA2 secretion channel, and reductions in the activity of iron co-factored superoxide dismutase and glutamine synthetase. After IV inoculation of 4dBCG, 95% of vaccine bacilli were eradicated from the spleens of mice within 60 days whereas the titer of BCG Tice was not significantly reduced. Subcutaneous vaccination with 4dBCG produced greater protection than vaccination with BCG against dissemination of an aerosolized challenge of M. tuberculosis to the spleen at 8 weeks post-challenge. At this time, 4dBCG-vaccinated mice also exhibited altered lung histopathology compared to BCG-vaccinated mice and control mice with less well-developed lymphohistiocytic nodules in the lung parenchyma. At 26 weeks post-challenge, 4dBCG-vaccinated mice but not BCG-vaccinated mice had significantly fewer challenge bacilli in the lungs than control mice. In conclusion, despite reduced persistence in mice a modified BCG vaccine with diminished antioxidants and glutamine synthetase is superior to the parent vaccine in conferring protection against M. tuberculosis. The targeting of multiple immune suppressive factors produced by BCG is a promising strategy for simultaneously improving vaccine safety and effectiveness.

  20. C57BL/6J MICE EXHIBIT REDUCED DOPAMINE D3 RECEPTOR-MEDIATED LOCOMOTOR-INHIBITORY FUNCTION RELATIVE TO DBA/2J MICE

    PubMed Central

    McNAMARA, R. K.; LEVANT, B.; TAYLOR, B.; AHLBRAND, R.; LIU, Y.; SULLIVAN, J. R.; STANFORD, K.; RICHTAND, N. M.

    2007-01-01

    Previous reports have identified greater sensitivity to the locomotor-stimulating, sensitizing, and reinforcing effects of amphetamine in inbred C57BL/6J mice relative to inbred DBA/2J mice. The dopamine D3 receptor (D3R) plays an inhibitory role in the regulation of rodent locomotor activity, and exerts inhibitory opposition to D1 receptor (D1R)-mediated signaling. Based on these observations, we investigated D3R expression and D3R-mediated locomotor-inhibitory function, as well as D1R binding and D1R-mediated locomotor-stimulating function, in C57BL/6J and DBA/2J mice. C57BL/6J mice exhibited lower D3R binding density (−32%) in the ventral striatum (nucleus accumbens/islands of Calleja), lower D3R mRNA expression (−26%) in the substantia nigra/ventral tegmentum, and greater D3R mRNA expression (+40%) in the hippocampus, relative to DBA/2J mice. There were no strain differences in DR3 mRNA expression in the ventral striatum or prefrontal cortex, nor were there differences in D1R binding in the ventral striatum. Behaviorally, C57BL/6J mice were less sensitive to the locomotor-inhibitory effect of the D3R agonist PD128907 (10 μg/kg), and more sensitive to the locomotor-stimulating effects of novelty, amphetamine (1 mg/kg), and the D1R-like agonist ±-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8,-diol hydrochloride (SKF38393) (5–20 mg/kg) than DBA/2J mice. While the selective D3R antagonist N-(4-[4-{2,3-dichlorphenyl}-1 piperazinyl]butyl)-2-fluorenylcarboxamide (NGB 2904) (0.01–1.0 mg/kg) augmented novelty-, amphetamine-, and SKF38393-induced locomotor activity in DBA/2J mice, it reduced novelty-induced locomotor activity in C57BL/6J mice. Collectively, these results demonstrate that C57BL/6J mice exhibit less D3R-mediated inhibitory function relative to DBA/2J mice, and suggest that reduced D3R-mediated inhibitory function may contribute to heightened sensitivity to the locomotor-stimulating effects of amphetamine in the C57BL/6J mouse strain

  1. Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.

    PubMed

    Raetz, Alan G; Xie, Yali; Kundu, Sucharita; Brinkmeyer, Megan K; Chang, Cindy; David, Sheila S

    2012-11-01

    Biallelic germline mutations in the base excision repair enzyme gene MUTYH lead to multiple colorectal adenomas and carcinomas referred to as MUTYH-associated polyposis. MUTYH removes adenine misincorporated opposite the DNA oxidation product, 8-oxoguanine (OG), thereby preventing accumulation of G:C to T:A transversion mutations. The most common cancer-associated MUTYH variant proteins when expressed in bacteria exhibit reduced OG:A mismatch affinity and adenine removal activity. However, direct evaluation of OG:A mismatch repair efficiency in mammalian cells has not been assessed due to the lack of an appropriate assay. To address this, we developed a novel fluorescence-based assay of OG:A repair and measured the repair capacity of MUTYH-associated polyposis variants expressed in Mutyh-/- mouse embryonic fibroblasts (MEFs). The repair of a single site-specific synthetic lesion in a green fluorescent protein reporter leads to green fluorescent protein expression with co-expression of a red fluorescent protein serving as the transfection control. Cell lines that stably express the MUTYH-associated polyposis variants G382D and Y165C have significantly lower OG:A repair versus wild-type MEFs and MEFs expressing human wild-type MUTYH. The MUTYH allele that encodes the Q324H variant is found at a frequency above 40% in samples from different ethnic groups and has long been considered phenotypically silent but has recently been associated with increased cancer risk in several clinical studies. In vitro analysis of Q324H MUTYH expressed in insect cells showed that it has reduced enzyme activity similar to that of the known cancer variant G382D. Moreover, we find that OG:A repair in MEFs expressing Q324H was significantly lower than wild-type controls, establishing that Q324H is functionally impaired and providing further evidence that this common variant may lead to increased cancer risk.

  2. Outdoor Exhibits

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The National Data Buoy Center (NDBC) at the John C. Stennis Space Center has exhibits located in front of the Visitors Center. These boat-shaped buoys are moored in areas of the ocean that experience hostile environmental conditions. The instruments installed gather information and relay it to the National Weather Service by satellite. Nomad buoys are 20 feet long and weigh 13,900 pounds. They provide information on wind speed and direction, humidity levels, air and sea surface temperature and air pressure. U.S. Coast Guard ships transport buoys to their mooring sites.

  3. Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting.

    PubMed

    Stengel, Andreas; Goebel, Miriam; Million, Mulugeta; Stenzel-Poore, Mary P; Kobelt, Peter; Mönnikes, Hubert; Taché, Yvette; Wang, Lixin

    2009-01-01

    Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a 16-h overnight fast and ip injection of gut hormones regulating food intake were compared in CRF-OE and wild type (WT) littermate mice along with brain Fos expression, circulating ghrelin levels, and gastric emptying of a nonnutrient meal. CRF-OE mice injected ip with saline showed a 47 and 44% reduction of 30-min and 4-h cumulative food intake response to an overnight fast, respectively, compared with WT. However, the 30-min food intake decrease induced by ip cholecystokinin (3 microg/kg) and increase by ghrelin (300 microg/kg) were similar in CRF-OE and WT mice. Overnight fasting increased the plasma total ghrelin to similar levels in CRF-OE and WT mice, although CRF-OE mice had a 2-fold reduction of nonfasting ghrelin levels. The number of Fos-immunoreactive cells induced by fasting in the arcuate nucleus was reduced by 5.9-fold in CRF-OE compared with WT mice whereas no significant changes were observed in other hypothalamic nuclei. In contrast, fasted CRF-OE mice displayed a 5.6-fold increase in Fos-immunoreactive cell number in the dorsal motor nucleus of the vagus nerve and a 34% increase in 20-min gastric emptying. These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response.

  4. Atlantic salmon (Salmo salar) fed L-carnitine exhibit altered intermediary metabolism and reduced tissue lipid, but no change in growth rate.

    PubMed

    Ji, H; Bradley, T M; Tremblay, G C

    1996-08-01

    Metabolic evidence was sought to explain the reduced body fat and increased body protein observed in Atlantic salmon fed diets supplemented with L-carnitine. By stimulating fatty acid oxidation, dietary carnitine might increase flux through pyruvate carboxylase and decrease flux through the branched-chain alpha-keto acid dehydrogenase complex, by increasing regulatory ratios of acetyl CoA:free enzyme A (CoA-SH) and ATP:ADP. Such changes could conserve nitrogen by providing more carbon for amino acid biosynthesis and by blocking oxidative loss of the branched-chain amino acids. Consistent with this hypothesis, salmon fed carnitine (23 mmol/kg diet) for 9 wk exhibited greater metabolic rates than cohorts fed a carnitine-free diet (P < 0.05) for the following: 1) 1-[14C] palmitate oxidation by liver cubes (48%) and by isolated hepatocytes (151%), 2) pyruvate-dependent [14 CO2]-fixation by isolated mitochondria (81%), 3) incorporation of 1-[14C] lactate into glucose by liver cubes (120%) and by isolated hepatocytes (210%), and 4) incorporation of [35S]-methionine into the acid-insoluble fraction of liver cubes (59%) and isolated hepatocytes (89%). Hepatic concentrations of seven amino acids, including the branched-chain amino acids, were greater (7-112%), as were the plasma concentrations of three of these (45-130%). However, 230% more enzyme in the mitochondria of carnitine-fed fish, and not a difference in the ratios of acetyl CoA:CoA-SH or ATP:ADP, appeared to account for accelerated flux through pyruvate carboxylase; flux through the dehydrogenase complex was unchanged. These results implicate induction of pyruvate carboxylase (or a reduction in turnover) and enhanced protein synthesis in the mechanism for carnitine-induced changes in gluconeogenesis and nitrogen metabolism.

  5. Monitoring the Surface Heat Island (shi) Effects of Industrial Enterprises

    NASA Astrophysics Data System (ADS)

    Şekertekin, A.; Kutoglu, Ş. H.; Kaya, S.; Marangoz, A. M.

    2016-06-01

    The aim of this study is to present the effects of industrial enterprises on Land Surface Temperature (LST) and to retrieve Surface Heat Island (SHI) maps of these regions. SHI is one of the types of Urban Heat Island (UHI) and as the urban areas grow in a city, UHI effect becomes bigger. The city centre of Zonguldak was chosen as study area and Landsat 5 satellite data were used as materials. Zonguldak has important industrial enterprises like thermal power plants and iron and steel plant. ERDEMIR is the biggest iron and steel plant in Turkey and it is one of the biggest ones in Europe, as well. There are three operating thermal power plants in the region namely CATES, ZETES1 and ZETES2. In order to investigate these industrial regions, Landsat 5 satellite data were processed using mono-window algorithm to retrieve LST and they were acquired on 11.09.1987, 18.09.2007 and 29.09.2011, respectively. The obtained results revealed that from 1987 to 2011, spatial and temporal variability in LST in industrial enterprises became higher than the surroundings. Besides, the sizes of SHIs in 2011 are bigger than the ones in 1987. For the countries and governments, having industrial enterprises is crucial for the development and it is also important to present the community better conditions in life. Thus, decision makers should consider mitigating the effects of these regions on LST.

  6. Shy birds play it safe: personality in captivity predicts risk responsiveness during reproduction in the wild.

    PubMed

    Cole, Ella F; Quinn, John L

    2014-05-01

    Despite a growing body of evidence linking personality to life-history variation and fitness, the behavioural mechanisms underlying these relationships remain poorly understood. One mechanism thought to play a key role is how individuals respond to risk. Relatively reactive and proactive (or shy and bold) personality types are expected to differ in how they manage the inherent trade-off between productivity and survival, with bold individuals being more risk-prone with lower survival probability, and shy individuals adopting a more risk-averse strategy. In the great tit (Parus major), the shy-bold personality axis has been well characterized in captivity and linked to fitness. Here, we tested whether 'exploration behaviour', a captive assay of the shy-bold axis, can predict risk responsiveness during reproduction in wild great tits. Relatively slow-exploring (shy) females took longer than fast-exploring (bold) birds to resume incubation after a novel object, representing an unknown threat, was attached to their nest-box, with some shy individuals not returning within the 40 min trial period. Risk responsiveness was consistent within individuals over days. These findings provide rare, field-based experimental evidence that shy individuals prioritize survival over reproductive investment, supporting the hypothesis that personality reflects life-history variation through links with risk responsiveness.

  7. Infant shy temperament predicts preschoolers Theory of Mind.

    PubMed

    Mink, Daniela; Henning, Anne; Aschersleben, Gisa

    2014-02-01

    The aim of this longitudinal study was to investigate the relation between infant temperament at 18 months and early Theory of Mind (ToM) abilities at 3 years of age. Temperament was assessed with the Early Childhood Behavior Questionnaire (ECBQ) and ToM by assessing children's understanding of divergent desires and beliefs, and of knowledge access. Our results are in line with a social-emotional reactivity perspective postulating more sophisticated ToM abilities for children with less reactive more observant temperament. Children with shy temperament at 18 months and at 3 years were better in reasoning about others' mental states at age 3. Language, siblings and parental education had no effect on ToM. Findings indicate that temperament is related to ToM earlier in development than previously found, and that this relation is thus not unique to false-belief understanding.

  8. [18 months law for the modernisation of the SHI--review and prospects].

    PubMed

    Steinbronn, R

    2005-01-01

    Balance of the law for the modernisation of the statutory health insurance (SHI) (GKV-Modernisierungsgesetz-GMG) is contradictory as measured by the original objectives. Although the legislators curtailed benefits and raised the co-payments, those insured could not profit from lower contributions. The anticipated lowering of the ancillary wage costs was missing thereby. However, many SHI funds could settle debts, but the expenditures rose again in 2005. The financial situation of most SHI funds is still strained. The new federal government will have to tackle a further and sustainable reform of the statutory health insurance soon.

  9. Meeting Report: Ordinary Meeting and Exhibition Meeting, 2006 June 24

    NASA Astrophysics Data System (ADS)

    McGee, H.; Mobberley, M.

    2007-06-01

    Prior to the Ordinary Meeting, the annual Exhibition was opened by Richard Miles, President, who said he was pleased to report that all but two of the Sections had display stands this year, and that most of the Directors had also been able to attend and were available for members who wished to discuss their work. Although we had almost a full day of talks to enjoy, members should not be shy of coming and going from the lecture theatre at will, and in particular must make sure they took sufficient time to do justice to the excellent Exhibition on offer.

  10. A prototypic modified risk tobacco product exhibits reduced effects on chemotaxis and transendothelial migration of monocytes compared with a reference cigarette.

    PubMed

    van der Toorn, Marco; Frentzel, Stefan; Goedertier, Didier; Peitsch, Manuel; Hoeng, Julia; De Leon, Hector

    2015-06-01

    Monocyte adhesion and migration to the subendothelial space represent critical steps in atherogenesis. Here, we investigated whether extracts from the aerosol of a prototypic modified risk tobacco product (pMRTP), based on heating rather than combusting tobacco, exhibited differential effects on the migratory behavior of monocytes compared with that from the reference cigarette, 3R4F. THP-1 cells, a monocytic cell line, and human coronary arterial endothelial cells (HCAECs) were used to investigate chemotaxis and transendothelial migration (TEM) of monocytes in conventional and impedance-based systems. THP-1 cells migrated through a monolayer of HCAECs in response to C-X-C motif ligand 12 (CXCL12), a chemokine involved in diverse cellular functions including chemotaxis and survival of stem cells. Treatment of THP-1 cells with extracts from 3R4F or pMRTP induced concentration-dependent increases in cytotoxicity (7-aminoactinomycin D), and inflammation (IL-8 and TNF-α). CXCL12-mediated chemotaxis and TEM were decreased in extract-treated THP-1 cells. Extracts from 3R4F were ~21 times more potent than those from pMRTP in all examined endpoints. Extracts from 3R4F and pMRTP induced concentration-dependent responses in assays of inflammation, cytotoxicity, chemotaxis, and TEM. Furthermore, our findings indicate that extracts from a pMRTP are significantly less cytotoxic and induce less inflammation than those from the reference cigarette, 3R4F.

  11. [On English translation of jun, chen, zuo and shi in science of prescription].

    PubMed

    Chen, Jin; Zhang, Qing-rong

    2007-10-01

    In this paper, English translation of JUN, CHEN, ZUO, and SHI in science of prescription of traditional Chinese medicine were discussed by hunting the headstream, analyzing and explaining their implication, discriminating and selecting the relative English terms.

  12. [Using the SHiPA with the elderly: a person-centered approach].

    PubMed

    Compagnone, Philippe D; Bergua, Valérie; Bouisson, Jean

    2006-12-01

    Qualitative differences in control, distance and relationship with other people were examined using multidimensional and configurational analyses with data from the SHiPA. The SHiPA, developed by Bouisson (2005), contributes to inform on psychological functioning the elderly, using open responses, no limited into choices, and assesses some aspects of distress and adaptative resources in common daily life events that are frequently causes of difficulties. Based on scores in differential weighting of SHiPA dimensions, multivariate analyses revealed five psychological functioning profiles, characterized by anxiety, depression, cognition, internality, satisfaction with life, and routinization levels. Analyse of the differences between SHiPA profiles suggested a first discrimination depending on the individuals, psychological resources level, and the situation of subjects in third and fourth age.

  13. Disease progresses more quickly in introverts. Shy, inhibited personalities may fare worse.

    PubMed

    2004-03-01

    Los Angeles researchers recently have discovered clinical evidence that HIV-positive people with shy and introverted personalities tend to have a faster disease progression and less optimal outcomes under antiretroviral treatment than do people with extroverted personalities.

  14. Why I Am Not SHY: A Reply to Tononi and Cirelli

    PubMed Central

    Frank, Marcos Gabriel

    2013-01-01

    In a recent article I reviewed an influential theory of sleep function, the “synaptic homeostasis hypothesis (SHY.)” According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep function and the brain, its underlying mechanisms are poorly defined. In an accompanying article, the authors of SHY responded at length. Their reply is thoughtful and provocative, but unfortunately many of the points I raised were not accurately represented or addressed. In this brief commentary, I attempt to clarify some points of confusion. I also explain why any theory of sleep function is incomplete without an understanding of the underlying cellular mechanisms. PMID:23476811

  15. Phycobilisome-Deficient Strains of Synechocystis sp. PCC 6803 Have Reduced Size and Require Carbon-Limiting Conditions to Exhibit Enhanced Productivity1[W][OPEN

    PubMed Central

    Lea-Smith, David J.; Bombelli, Paolo; Dennis, John S.; Scott, Stuart A.; Smith, Alison G.; Howe, Christopher J.

    2014-01-01

    Reducing excessive light harvesting in photosynthetic organisms may increase biomass yields by limiting photoinhibition and increasing light penetration in dense cultures. The cyanobacterium Synechocystis sp. PCC 6803 harvests light via the phycobilisome, which consists of an allophycocyanin core and six radiating rods, each with three phycocyanin (PC) discs. Via targeted gene disruption and alterations to the promoter region, three mutants with two (pcpcT→C) and one (ΔCpcC1C2:pcpcT→C) PC discs per rod or lacking PC (olive) were generated. Photoinhibition and chlorophyll levels decreased upon phycobilisome reduction, although greater penetration of white light was observed only in the PC-deficient mutant. In all strains cultured at high cell densities, most light was absorbed by the first 2 cm of the culture. Photosynthesis and respiration rates were also reduced in the ΔCpcC1C2:pcpcT→C and olive mutants. Cell size was smaller in the pcpcT→C and olive strains. Growth and biomass accumulation were similar between the wild-type and pcpcT→C under a variety of conditions. Growth and biomass accumulation of the olive mutant were poorer in carbon-saturated cultures but improved in carbon-limited cultures at higher light intensities, as they did in the ΔCpcC1C2:pcpcT→C mutant. This study shows that one PC disc per rod is sufficient for maximal light harvesting and biomass accumulation, except under conditions of high light and carbon limitation, and two or more are sufficient for maximal oxygen evolution. To our knowledge, this study is the first to measure light penetration in bulk cultures of cyanobacteria and offers important insights into photobioreactor design. PMID:24760817

  16. Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates

    PubMed Central

    Kawamura, Takuji; Miyagawa, Shigeru; Fukushima, Satsuki; Maeda, Akira; Kashiyama, Noriyuki; Kawamura, Ai; Miki, Kenji; Okita, Keisuke; Yoshida, Yoshinori; Shiina, Takashi; Ogasawara, Kazumasa; Miyagawa, Shuji; Toda, Koichi; Okuyama, Hiroomi; Sawa, Yoshiki

    2016-01-01

    Summary Induced pluripotent stem cells (iPSCs) can serve as a source of cardiomyocytes (CMs) to treat end-stage heart failure; however, transplantation of genetically dissimilar iPSCs even within species (allogeneic) can induce immune rejection. We hypothesized that this might be limited by matching the major histocompatibility complex (MHC) antigens between the donor and the recipient. We therefore transplanted fluorescence-labeled (GFP) iPSC-CMs donated from a macaque with homozygous MHC haplotypes into the subcutaneous tissue and hearts of macaques having heterozygous MHC haplotypes (MHC-matched; group I) or without identical MHC alleles (group II) in conjunction with immune suppression. Group I displayed a higher GFP intensity and less immune-cell infiltration in the graft than group II. However, MHC-matched transplantation with single or no immune-suppressive drugs still induced a substantial host immune response to the graft. Thus, the immunogenicity of allogeneic iPSC-CMs was reduced by MHC-matched transplantation although a requirement for appropriate immune suppression was retained for successful engraftment. PMID:26905198

  17. [Professor Li Shi-zhen's clinical experiences on compatibility application of hegu (LI 4)].

    PubMed

    Li, Chuan-qi

    2010-02-01

    The present paper introduces professor LI Shi-zhen's clinical experiences on compatibility application of Hegu (LI 4). Hegu (LI 4) is mostly used to treat acute pyreticosis, exterior syndrome of exogenous diseases, mind diseases and deficiency of vital energy. Acupuncture at this acupoint by using reducing method can dispel wind to relieve exterior syndrome, clear away heat to disperse lung. Powerful stimulation by needle can dredge stagnant meridian, open orifice to activate spirit. Acupuncture at this acupoint by using reinforcing method can invigorate qi to strengthen superficies and replenish qi to prevent collapse. Based on this method, reinforcing Zusanli (ST 36) and Baihui (GV 20) can strengthen middle energizer to nourish qi, which show the same benefits as Buzhong Yiqi Decoction; reinforcing Sanyinjiao (SP 6) can nourish both qi and blood, which show the same benefits as Decoction of Eight Ingredients; reducing Neiting (ST 44) can clear away evil heat of qifen in yangming meridians, which show the same benefits as Baihu Decoction.

  18. SiPM readout for the SHiP timing detector

    NASA Astrophysics Data System (ADS)

    Betancourt, C.; Bezshyiko, I.; Brundler, R.; Serra, N.; Storaci, B.

    2017-02-01

    The SHiP experiment is a new general purpose fixed target experiment proposed at the CERN SPS accelerator. A dedicated beam line in the North Area will be aimed at a fixed target station, followed by a magnetic shield to reduce beam induced background. The experiment will comprise a compact tau neutrino detector and a detector to search for hidden particles. Background rejection is ensured by use of background taggers and a dedicated timing detector. The timing detector will reduce combinatorial di-muon background by requiring incoming particles to be coincident in time within 100 ps. One option for the timing detector consists of columns of horizontal scintillating bars read-out on each end by Silicon Photomultiplier arrays. This study includes characterization of SiPMs from different manufacturers to be used in the timing detector in terms of Current-Voltage behavior, cross-talk probability, dark count rate and single photon timing resolution. Initial results of the time resolution of a EJ-200 scintillating bar read out on both ends by a single SiPM are presented.

  19. AT-RvD1 Promotes Resolution of Inflammation in NOD/ShiLtJ mice

    PubMed Central

    Wang, Ching-Shuen; Maruyama, Christina L.; Easley, Justin T.; Trump, Bryan G.; Baker, Olga J.

    2017-01-01

    Sjögren’s syndrome (SS) is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Treatments for hyposalivation are limited to the use of saliva substitutes and medications that provide only temporary relief. In light of the high degree of need and the limitations of current therapies, development of alternative treatments to restore functioning is essential. Resolvins (Rv), which are highly potent lipid mediators, offer a viable alternative for better treating inflammatory diseases such as SS. The goal of this study was to determine whether systemic preventive treatment with Aspirin-triggered RvD1 (AT-RvD1) reduces inflammation and preserves secretory functioning in NOD/ShiLtJ SS-like mice. Our results indicate that systemic treatment with AT-RvD1 diminishes the progression of the disease in salivary epithelium from female mice as follows: (a) improves secretory function, (b) reduces pro-inflammatory molecule gene expression, (c) increases anti-inflammatory molecule gene expression and (d) induces M2 macrophage polarization. Finally, AT-RvD1 decreases lymphocytic infiltration into the salivary glands when used with small doses of the steroid, dexamethasone, and promotes the tissue healing process. PMID:28361884

  20. The SHiP experiment at CERN SPS

    NASA Astrophysics Data System (ADS)

    Di Crescenzo, A.; SHiP Collaboration

    2016-01-01

    SHiP is a new general purpose fixed target facility, whose Technical Proposal has been recently submitted to the CERN SPS Committee. In its initial phase, the 400GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 pot in 5years. A dedicated detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The beam dump is also an ideal source of tau neutrinos, the less known particle in the Standard Model. Another dedicated detector, based on the Emulsion Cloud Chamber technology already used in the OPERA experiment, will allow to perform for the first time measurements of the tau neutrino deep inelastic scattering cross section. Tau neutrinos will be distinguished from tau anti-neutrinos, thus providing the first observation of the tau anti-neutrino.

  1. Midwives in China: 'jie sheng po' to 'zhu chan shi'.

    PubMed

    Harris, Amanda; Belton, Suzanne; Barclay, Lesley; Fenwick, Jenny

    2009-04-01

    We explore the position of midwifery in contemporary China, and draw on fieldwork conducted in Shanxi and Sichuan Provinces during 2005 and 2006, the available literature in English and to a lesser extent in Mandarin. We also explore the historical antecedents to the present-day professional status, practices and position within the health-care system of midwifery in China. We consider the effect on midwifery of the place of biomedicine in the modernising project of the post-reform State, the shift of birth from the private to the public domain, the rise of the medical profession, the medicalisation of birth and the increasing use of technology, and trace changes in the nature of relations between midwives, doctors and the State from Imperial China to the present day. In particular, we examine the changes that have occurred as midwifery has moved from the arena of the lay practitioner ('jie sheng po') to the professional ('zhu chan shi'). We draw out and critique some ways that midwives act to differentiate themselves and lay claim to a variant body of practice-based knowledge, yet question the capacity of midwifery in China today to assert, in any substantial way, a professional identity that distinguishes it from medical obstetric practice.

  2. Revolution, Modernity and (Trans)National Shi`i Islam: Rethinking Religious Conversion in Senegal

    PubMed Central

    Leichtman, Mara A.

    2013-01-01

    The establishment of a Shi`i Islamic network in Senegal is one alternative to following the country's dominant Sufi orders. I examine Senegalese conversion narratives and the central role played by the Iranian Revolution, contextualizing life stories (trans)nationally in Senegal's political economy and global networks with Iran and Lebanon. Converts localize foreign religious ideologies into a ‘national’ Islam through the discourse that Shi`i education can bring peace and economic development to Senegal. Senegalese Shi`a perceive that proselytizing, media technologies, and Muslim networking can lead to social, cultural and perhaps even political change through translating the Iranian Revolution into a non-violent reform movement. PMID:23833329

  3. Preliminary Evaluation of a Social Skills Training and Facilitated Play Early Intervention Programme for Extremely Shy Young Children in China

    ERIC Educational Resources Information Center

    Li, Yan; Coplan, Robert J.; Wang, Yuemin; Yin, Jingtong; Zhu, Jingjing; Gao, Zhuqing; Li, Linhui

    2016-01-01

    The goal of this study was to provide a preliminary evaluation of a social skills and facilitated play early intervention programme to promote social interaction, prosocial behaviours and socio-communicative skills among young extremely shy children in China. Participants were a sample of n = 16 extremely shy young children attending kindergarten…

  4. Enhancing Contextualized Curriculum: Integrated Identity in Young Shi'i Muslim Arabic-Canadian Students' Social Worlds

    ERIC Educational Resources Information Center

    Al-Fartousi, May

    2016-01-01

    This research explored 10 young female Shi'i Muslim Arabic-Canadian students' experiences associated with wearing the Hijab (headscarf) within their home, community, and predominantly White Canadian public elementary school environments. The in-depth case study sought to address the dearth of information about Shi'is' experiences in schools…

  5. Canadian Early-Childhood Educators' Perceptions of Children's Gendered Shy, Aggressive, and Prosocial Behaviors

    ERIC Educational Resources Information Center

    Woods, Heather; Bosacki, Sandra; Coplan, Robert J.

    2016-01-01

    Early childhood educators' (ECE) perceptions of gender roles may contribute to the development of children's own gender-role identities. This qualitative study examined 40 Canadian female ECEs' perceptions of gender and children's shy, aggressive, and prosocial behaviors. Content analysis of extensive interviews revealed three themes: (1) shyness…

  6. A Cognitive-Behavioral Approach to Social Skills Training with Shy Persons.

    ERIC Educational Resources Information Center

    Haynes-Clements, Lynda A.; Avery, Arthur W.

    1984-01-01

    Developed, implemented, and evaluated a social skills training program for shy persons (N=12). Results indicated that subjects in the experimental group, relative to the control group, significantly decreased their level of social anxiety, decreased their negative self-statements, and increased their perceived ability to participate actively in…

  7. Canadian Elementary School Teachers' Perceptions of Gender Differences in Shy Girls and Boys in the Classroom

    ERIC Educational Resources Information Center

    Akseer, Tabasum; Bosacki, Sandra L.; Rose-Krasnor, Linda; Coplan, Robert J.

    2014-01-01

    Shyness may play a significant role in children's socio-emotional and cognitive competence in the classroom. This qualitative study investigated elementary school teachers' perceptions of the concept of shyness in their students. In particular, we explored teachers' perceptions regarding the role that gender plays in shy children's behaviours, and…

  8. Preservice Teachers' Knowledge of Effective Classroom Management Strategies: Shy or Withdrawn Students.

    ERIC Educational Resources Information Center

    Lacina-Gifford, Lorna J.; Kher, Neelam; Besant, Kyesha

    This study identified preservice teachers' knowledge about effective and ineffective classroom management strategies. A group of 108 preservice teachers at a southern rural public university generated classroom management strategies in response to hypothetical vignettes depicting shy and withdrawn student behavior. Researchers coded the extended…

  9. Genetic structure, conservation genetics and evidence of speciation by range expansion in shy and white-capped albatrosses.

    PubMed

    Abbott, Cathryn L; Double, Michael C

    2003-11-01

    Six variable microsatellite loci were used to examine genetic structuring in the closely related shy albatross (Thalassarche cauta) and white-capped albatross (T. steadi). First, levels of genetic differentiation between the species, and among three populations within each species, were analysed using amova, FST and RST. We found high levels of genetic structuring and detected many unshared alleles between the species, which provide strong evidence against any contemporary gene flow between them. Within each species, shy albatross populations were found to be genetically distinct whereas white-capped albatross populations were undifferentiated, which implies that dispersal events are much rarer in the former than in the latter. These results formed the basis for the recommendation that the three white-capped albatross populations (as a whole) and each shy albatross population be treated as separate units for conservation. Second, levels of genetic diversity and allelic patterns in shy and white-capped albatrosses were assessed for whether they support earlier mtDNA results suggesting that shy albatrosses arose through range expansion of white-capped albatrosses. All measures indicated lower genetic diversity within shy albatrosses than within white-capped albatrosses and upheld the hypothesis that shy albatrosses were founded by white-capped albatrosses.

  10. Phylogeography of shy and white-capped albatrosses inferred from mitochondrial DNA sequences: implications for population history and taxonomy.

    PubMed

    Abbott, Cathryn L; Double, Michael C

    2003-10-01

    The evolutionary relationship between shy (Thalassarche cauta) and white-capped (T. steadi) albatrosses was examined using mitochondrial control region sequences. Results were interpreted in the context of a recent and contentious taxonomic revision that recommended full species status for shy and white-capped albatrosses. Low sequence divergence between shy and white-capped albatrosses (1.8%) and between their close relatives, Salvin's and Chatham albatrosses (2.9%), was observed. Much higher sequence divergence was found between the shy/white-capped pair and the Salvin's/Chatham pair (7.0%). Phylogenetic analyses confirmed the separation of the shy/white-capped pair from the Salvin's/Chatham pair but did not provide species-level resolution. Phylogeographic analyses, including a nested clade analysis, FST estimates and an analysis of molecular variance, indicated unambiguous genetic structuring between shy and white-capped albatrosses, thus confirming the demographic isolation of the species, but showed little to no structuring within each species. The geographical distribution of mtDNA haplotypes and other evidence suggest that shy albatrosses arose through range expansion by white-capped albatrosses.

  11. Ethics on Exhibit

    ERIC Educational Resources Information Center

    Vick, Randy M.

    2011-01-01

    This article discusses ethical questions raised by an exhibition of work by an artist with a history of mental illness and the exhibition's relevance to art therapy and “outsider art” discourse on the subject. Considerations for how such an exhibit could be handled had the circumstances included an art therapist and art therapy client are…

  12. Do Shy Kids Have a Chance of Getting to College?

    ERIC Educational Resources Information Center

    Hanley, Thomas A., Jr.

    2005-01-01

    In this article, the author discusses the importance of teacher recommendations for students who exhibit extreme shyness during college interviews. Admission committees at some colleges are apparently questioning the propensity to favor students who evidence leadership, and who are naturally outgoing, in seeking to balance and diversify the…

  13. Drought-Up-Regulated TaNAC69-1 is a Transcriptional Repressor of TaSHY2 and TaIAA7, and Enhances Root Length and Biomass in Wheat.

    PubMed

    Chen, Dandan; Richardson, Terese; Chai, Shoucheng; Lynne McIntyre, C; Rae, Anne L; Xue, Gang-Ping

    2016-10-01

    A well-known physiological adaptation process of plants encountering drying soil is to achieve water balance by reducing shoot growth and maintaining or promoting root elongation, but little is known about the molecular basis of this process. This study investigated the role of a drought-up-regulated Triticum aestivum NAC69-1 (TaNAC69-1) in the modulation of root growth in wheat. TaNAC69-1 was predominantly expressed in wheat roots at the early vegetative stage. Overexpression of TaNAC69-1 in wheat roots using OsRSP3 (essentially root-specific) and OsPIP2;3 (root-predominant) promoters resulted in enhanced primary seminal root length and a marked increase in maturity root biomass. Competitive growth analysis under water-limited conditions showed that OsRSP3 promoter-driven TaNAC69-1 transgenic lines produced 32% and 35% more above-ground biomass and grains than wild-type plants, respectively. TaNAC69-1 overexpression in the roots down-regulated the expression of TaSHY2 and TaIAA7, which are from the auxin/IAA (Aux/IAA) transcriptional repressor gene family and are the homologs of negative root growth regulators SHY2/IAA3 and IAA7 in Arabidopsis. The expression of TaSHY2 and TaIAA7 in roots was down-regulated by drought stress and up-regulated by cytokinin treatment, which inhibited root growth. DNA binding and transient expression analyses revealed that TaNAC69-1 bound to the promoters of TaSHY2 and TaIAA7, acted as a transcriptional repressor and repressed the expression of reporter genes driven by the TaSHY2 or TaIAA7 promoter. These data suggest that TaNAC69-1 is a transcriptional repressor of TaSHY2 and TaIAA7 homologous to Arabidopsis negative root growth regulators and is likely to be involved in promoting root elongation in drying soil.

  14. Gibberellin deficiency is responsible for shy-flowering nature of Epipremnum aureum

    PubMed Central

    Hung, Chiu-Yueh; Qiu, Jie; Sun, Ying-Hsuan; Chen, Jianjun; Kittur, Farooqahmed S.; Henny, Richard J.; Jin, Gulei; Fan, Longjiang; Xie, Jiahua

    2016-01-01

    Epipremnum aureum is an extremely popular houseplant belonging to the Araceae family of angiosperms, but it does not flower either in the wild or under cultivation. We uncovered the potential causes of its shy-flowering nature by building the transcriptome using next-generation sequencing and identifying floral-related genes that are differentially expressed between vertical growth (VG, adult) and horizontal growth (HG, juvenile) plants. Transcripts of the gibberellin (GA) biosynthetic gene EaGA3ox1 and GA-responsive floral meristem identity gene EaLFY were absent in both VG and HG plants, suggesting that a deficiency of bioactive GAs may be responsible for its shy-flowering nature. This hypothesis is supported by undetectable or low levels of three bioactive GAs, and exogenous GA3 triggered flowering in both plants. Our study resolves the mystery why E. aureum fails to flower, and reveals the positive role of GAs in floral transition in perennials. PMID:27345283

  15. SHiP: a new multipurpose beam-dump experiment at the SPS

    NASA Astrophysics Data System (ADS)

    Dijkstra, H. B.

    2016-11-01

    SHiP is an experiment to look for very weakly interacting particles at a new to be constructed beam-dump facility at the CERN SPS. The SHiP Technical Proposal has been submitted to the CERN SPS Committee in April 2015. The 400 GeV/c proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2 × 1020 proton on target in five years. A detector located downstream of the target, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below a few GeV/c2. The main focus will be the physics of the so-called Hidden Portals, i.e. search for Dark Photons, Light scalars and pseudo-scalars, and Heavy Neutral Leptons (HNL). The sensitivity to HNL will allow for the first time to probe, in the mass range between the kaon and the charm meson mass, a coupling range for which Baryogenesis and active neutrino masses could also be explained. Integrated in SHiP is an Emulsion Cloud Chamber, already used in the OPERA experiment, which will allow to study active neutrino cross-sections and angular distributions. In particular SHiP can distinguish between vτ and v¯τ, and their deep inelastic scattering cross sections will be measured with statistics three orders of magnitude larger than currently available.

  16. An Exhibit for Touching.

    ERIC Educational Resources Information Center

    Hunt, Susan

    1979-01-01

    An exhibit designed for visually handicapped persons presented by the Kalamazoo (Michigan) Institute of Art included bronze sculptures and oil paintings from the institute's permanent collection. (CL)

  17. Development of a Summarized Health Index (SHI) for Use in Predicting Survival in Sea Turtles

    PubMed Central

    Li, Tsung-Hsien; Chang, Chao-Chin; Cheng, I-Jiunn; Lin, Suen-Chuain

    2015-01-01

    Veterinary care plays an influential role in sea turtle rehabilitation, especially in endangered species. Physiological characteristics, hematological and plasma biochemistry profiles, are useful references for clinical management in animals, especially when animals are during the convalescence period. In this study, these factors associated with sea turtle surviving were analyzed. The blood samples were collected when sea turtles remained alive, and then animals were followed up for surviving status. The results indicated that significantly negative correlation was found between buoyancy disorders (BD) and sea turtle surviving (p < 0.05). Furthermore, non-surviving sea turtles had significantly higher levels of aspartate aminotranspherase (AST), creatinine kinase (CK), creatinine and uric acid (UA) than surviving sea turtles (all p < 0.05). After further analysis by multiple logistic regression model, only factors of BD, creatinine and UA were included in the equation for calculating summarized health index (SHI) for each individual. Through evaluation by receiver operating characteristic (ROC) curve, the result indicated that the area under curve was 0.920 ± 0.037, and a cut-off SHI value of 2.5244 showed 80.0% sensitivity and 86.7% specificity in predicting survival. Therefore, the developed SHI could be a useful index to evaluate health status of sea turtles and to improve veterinary care at rehabilitation facilities. PMID:25803431

  18. Development of a Summarized Health Index (SHI) for use in predicting survival in sea turtles.

    PubMed

    Li, Tsung-Hsien; Chang, Chao-Chin; Cheng, I-Jiunn; Lin, Suen-Chuain

    2015-01-01

    Veterinary care plays an influential role in sea turtle rehabilitation, especially in endangered species. Physiological characteristics, hematological and plasma biochemistry profiles, are useful references for clinical management in animals, especially when animals are during the convalescence period. In this study, these factors associated with sea turtle surviving were analyzed. The blood samples were collected when sea turtles remained alive, and then animals were followed up for surviving status. The results indicated that significantly negative correlation was found between buoyancy disorders (BD) and sea turtle surviving (p < 0.05). Furthermore, non-surviving sea turtles had significantly higher levels of aspartate aminotranspherase (AST), creatinine kinase (CK), creatinine and uric acid (UA) than surviving sea turtles (all p < 0.05). After further analysis by multiple logistic regression model, only factors of BD, creatinine and UA were included in the equation for calculating summarized health index (SHI) for each individual. Through evaluation by receiver operating characteristic (ROC) curve, the result indicated that the area under curve was 0.920 ± 0.037, and a cut-off SHI value of 2.5244 showed 80.0% sensitivity and 86.7% specificity in predicting survival. Therefore, the developed SHI could be a useful index to evaluate health status of sea turtles and to improve veterinary care at rehabilitation facilities.

  19. A Teaching Aids Exhibition.

    ERIC Educational Resources Information Center

    Mahanja, Salah

    1985-01-01

    Describes an exhibition for the benefit of teachers of English in Arab Primary Schools, which was prepared by third-year students at the Teachers College for Arab Teachers. The exhibition included games, songs, audiovisual aids, crossword puzzles, vocabulary, spelling booklets, preposition aids, and worksheet and lesson planning aids. (SED)

  20. Communicating Science through Exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.; Harold, J.; Morrow, C.

    It is critically important for the public to better understand the scientific process. Museum exhibitions are an important part of informal science education that can effectively reach public audiences as well as school groups. They provide an important gateway for the public to learn about compelling scientific endeavors. There are many ways for scientists to help develop science exhibitions. The Space Science Institute (SSI) is a national leader in producing traveling science exhibitions and their associated educational programming (i.e. interactive websites, educator workshops, public talks, instructional materials). Two of its exhibitions, Space Weather Center and MarsQuest, are currently on tour. Another exhibition, Alien Earths, is in development. The Space Weather Center was developed in partnership with various research missions at NASA's Goddard Space Flight Center. MarsQuest is a 5000 square-foot traveling exhibition. The exhibit's second 3-year tour began this January at the Detroit Science Center. It is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and to learn more about their own planet in the process. The 3,000 square-foot traveling exhibition, called Alien Earths, will bring origins-related research and discoveries to students and the American public. Alien Earths has four interrelated exhibit areas: Our Place in Space, Star Birth, PlanetQuest, and Search for Life. Exhibit visitors will explore the awesome events surrounding the birth of stars and planets; they will join scientists in the hunt for planets outside our solar system including those that may be in ``habitable zones'' around other stars; and finally they will be able to learn about how scientists are looking for signs of life beyond Earth. Besides the exhibits, SSI is also developing interactive web sites based on exhibit themes. New technologies are transforming the Web from a static medium to an interactive environment with tremendous

  1. New Hurricane Exhibit

    NASA Technical Reports Server (NTRS)

    2007-01-01

    A new exhibit in StenniSphere depicting NASA's role in hurricane prediction and research and SSC's role in helping the region recover from Hurricane Katrina. The cyclone-shaped exhibit focuses on the effects of the Aug. 29, 2005 storm and outlines how NASA is working to improve weather forecasting. Through photos, 3-D models and digital animations, the exhibit tells the story of what happened inside the storm and how NASA's scientific research can increase the accuracy of hurricane tracking and modeling.

  2. Test Control Center exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  3. Communicating Science through Exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, Paul

    2005-04-01

    It is critically important for the public to better understand the scientific process. Museum exhibitions are an important part of informal science education that can effectively reach public audiences as well as school groups. They provide an important gateway for the public to learn about compelling scientific endeavors. Science exhibitions also provide a marvelous opportunity for scientists to become engaged in the exhibit development process. The Space Science Institute (SSI) is a national leader in producing traveling science exhibitions and their associated educational programming (i.e. interactive websites, educator workshops, public talks, instructional materials). The focus of this presentation will be on two of its exhibit projects: MarsQuest (on tour for four years) and Alien Earths (its tour began early in 2005). MarsQuest is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and to learn more about their own planet in the process. Alien Earths will bring origins-related research and discoveries to students and the American public. It has four interrelated exhibit areas: Our Place in Space, Star Birth, Planet Quest, and Search for Life. Exhibit visitors will explore the awesome events surrounding the birth of stars and planets; they will join scientists in the hunt for planets outside our solar system including those that may be in ``habitable zones'' around other stars; and finally they will be able to learn about how scientists are looking for signs of life beyond Earth. SSI is also developing interactive web sites based on exhibit themes. New technologies are transforming the Web from a static medium to an interactive environment with tremendous potential for informal education and inquiry-based investigations. This talk will focus on the role informal science projects play in effectively communicating science to a broad, public audience.

  4. Swamp to Space exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The menacing-looking alligator is really harmless. It is one of the realistic props to help convince visitors that the feel of the swamp is real in StenniSphere's Swamp to Space exhibit at John C. Stennis Space Center in Hancock County, Miss. The historical section of the Swamp to Space exhibit tells the story of why and how Stennis Space Center came to be. It also pays tribute to the families who moved their homes to make way for the space age in Mississippi.

  5. Pictures at an Exhibition.

    ERIC Educational Resources Information Center

    Kunz, Walter S., Jr.

    1997-01-01

    Describes the Youth Art Month exhibit in Howard County (Maryland) where students submitted their art focusing on school buildings and their interiors. Their art reveals concerns and desires about overcrowding, space utilization, school building height, outside lighting, solitude needs, and visual stimulation. The artwork is discussed in terms of…

  6. Exhibitions in Sight.

    ERIC Educational Resources Information Center

    Wasserman, Burton

    1978-01-01

    Early in the eighteenth century, Pompeii was discovered, a city that had been hidden for sixteen centuries by volcanic lava. There is a traveling exhibition of the sculptures, friezes, mosaics, and paintings being shown around the United States. Described is the history and contents of "Pompeii--A.D. 79." (RK)

  7. 1989 Architectural Exhibition Winners.

    ERIC Educational Resources Information Center

    School Business Affairs, 1990

    1990-01-01

    Winners of the 1989 Architectural Exhibition sponsored annually by the ASBO International's School Facilities Research Committee include the Brevard Performing Arts Center (Melbourne, Florida), the Capital High School (Santa Fe, New Mexico), Gage Elementary School (Rochester, Minnesota), the Lakewood (Ohio) High School Natatorium, and three other…

  8. Exhibition in Sight

    ERIC Educational Resources Information Center

    Wasserman, Burton

    1978-01-01

    Ludwig Mies van der Rohe is known primarily as an architect. However, he also designed chairs and tables. Discusses an exhibit held in New York City a few months ago which showed how well the famous architect achieved his goals in the area of furniture design. (Author/RK)

  9. [Study of MA Shi and ZHANG Jiebin's Annotations of Nei Jing].

    PubMed

    Wang, Dan

    2012-05-01

    MA Shi and ZHANG Jie-bin are famous annotators of Huangdi Neijing and their annotations are well- regarded. However, influenced by the style of practice of the Ming dynasty, some of their annotations are less than satisfactory. For instance, the words "ni" and "cong" in the phrase "Ni cong yin yang" are synonyms, which mean obedience, and the meaning of the word "an" in the phrase "an er shou zhi" is not "message" or "examination" but "inhibition". Also, the word "zou" in the phrase "gu hao zou" is "to run"; "qu" in the phrase "qu pijie" means "to leave". This thesis raises several incorrect annotations for the readers' reference.

  10. [Japanese monograph of dietary Chinese materia medica: Ben chao shi jian].

    PubMed

    Zhou, Min

    2009-01-01

    Ben chao shi jian was a monograph of dietary Chinese materia medica written by Japanese doctor: [see text], following the style of Ben cao gang mu (Compendium of Materia Medica). The book consulted Ben cao gang mu and associated with the actual situation of Japan, making elaborate illustrations on the function, toxicity, form feature, manufacture and collection of 442 kinds of dietary Chinese material medica produced from Japan and combining organically with all kinds of knowledges including medicice and pharmacology, health preservation, nutriology and gastrology etc. It was a very important work in the developmental history of dietology and medicative dietology in Japan with high practical and academic values.

  11. Starship 2040 Exhibit

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This photograph shows the Starship 2040 leaving the Marshall Space Flight Center (MSFC) for the exhibit site. Developed by the Space Transportation Directorate at MSFC, the Starship 2040 exhibit is housed in a 48-ft (14.6-m) tractor and trailer rig, permitting it to travel around the Nation, demonstrating NASA's vision of what commercial spaceflight might be like 40 years from now. All the irnovations suggested aboard the exhibit, automated vehicle health monitoring systems, high-energy propulsion drive, navigational aids and emergency and safety systems, are based on concepts and technologies now being studied at NASA Centers and partner institutions around the Nation. NASA is the nation's premier agency for development of the space transportation system, including future-generation reusable launch vehicles. Such systems, the keys to a 'real' Starship 2040, require revolutionary advances in critical aerospace technologies, from thermal, magnetic, chemical, and propellantless propulsion systems to new energy sources such as space solar power or antimatter propulsion. These and other advances are now being studied, developed, and tested at NASA field centers and partner institutions all over the Nation.

  12. Starship 2040 Exhibit

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This photograph shows onlookers viewing displays within the Starship 2040 exhibit on display at Joe Davis Stadium in Huntsville, Alabama. Developed by the Space Transportation Directorate at Marshall Space Flight Center (MSFC), the Starship 2040 exhibit is housed in a 48-ft (14.6-m) tractor and trailer rig, permitting it to travel around the Nation, demonstrating NASA's vision of what commercial spaceflight might be like 40 years from now. All the irnovations suggested aboard the exhibit (automated vehicle health monitoring systems, high-energy propulsion drive, navigational aids, and emergency and safety systems) are based on concepts and technologies now being studied at NASA Centers and partner institutions around the Nation. NASA is the Nation's premier agency for development of the space transportation system, including future-generation reusable launch vehicles. Such systems, the keys to a 'real' Starship 2040, require revolutionary advances in critical aerospace technologies, from thermal, magnetic, chemical, and propellantless propulsion systems to new energy sources such as space solar power or antimatter propulsion. These and other advances are now being studied, developed, and tested at NASA field centers and partner institutions all over the Nation.

  13. Starship 2040 Exhibit

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This photograph shows Justin Varnadore, son of a Marshall TV employee, at the controls of one of the many displays within the Starship 2040 exhibit on display at Joe Davis Stadium in Huntsville, Alabama. Developed by the Space Transportation Directorate at Marshall Space Flight Center (MSFC), the Starship 2040 exhibit is housed in a 48-ft (14.6-m) tractor and trailer rig, permitting it to travel around the Nation, demonstrating NASA's vision of what commercial spaceflight might be like 40 years from now. All the irnovations suggested aboard the exhibit (automated vehicle health monitoring systems, high-energy propulsion drive, navigational aids, and emergency and safety systems) are based on concepts and technologies now being studied at NASA Centers and partner institutions around the Nation. NASA is the Nation's premier agency for development of the space transportation system, including future-generation reusable launch vehicles. Such systems, the keys to a 'real' Starship 2040, require revolutionary advances in critical aerospace technologies, from thermal, magnetic, chemical, and propellantless propulsion systems to new energy sources such as space solar power or antimatter propulsion. These and other advances are now being studied, developed, and tested at NASA field centers and partner institutions all over the Nation.

  14. Online Exhibits & Concept Maps

    NASA Astrophysics Data System (ADS)

    Douma, M.

    2009-12-01

    Presenting the complexity of geosciences to the public via the Internet poses a number of challenges. For example, utilizing various - and sometimes redundant - Web 2.0 tools can quickly devour limited time. Do you tweet? Do you write press releases? Do you create an exhibit or concept map? The presentation will provide participants with a context for utilizing Web 2.0 tools by briefly highlighting methods of online scientific communication across several dimensions. It will address issues of: * breadth and depth (e.g. from narrow topics to well-rounded views), * presentation methods (e.g. from text to multimedia, from momentary to enduring), * sources and audiences (e.g. for experts or for the public, content developed by producers to that developed by users), * content display (e.g. from linear to non-linear, from instructive to entertaining), * barriers to entry (e.g. from an incumbent advantage to neophyte accessible, from amateur to professional), * cost and reach (e.g. from cheap to expensive), and * impact (e.g. the amount learned, from anonymity to brand awareness). Against this backdrop, the presentation will provide an overview of two methods of online information dissemination, exhibits and concept maps, using the WebExhibits online museum (www.webexhibits.org) and SpicyNodes information visualization tool (www.spicynodes.org) as examples, with tips on how geoscientists can use either to communicate their science. Richly interactive online exhibits can serve to engage a large audience, appeal to visitors with multiple learning styles, prompt exploration and discovery, and present a topic’s breadth and depth. WebExhibits, which was among the first online museums, delivers interactive information, virtual experiments, and hands-on activities to the public. While large, multidisciplinary exhibits on topics like “Color Vision and Art” or “Calendars Through the Ages” require teams of scholars, user interface experts, professional writers and editors

  15. Making Muslim babies: IVF and gamete donation in Sunni versus Shi'a Islam.

    PubMed

    Inhorn, Marcia C

    2006-12-01

    Medical anthropological research on science, biotechnology, and religion has focused on the "local moral worlds" of men and women as they make difficult decisions regarding their health and the beginnings and endings of human life. This paper focuses on the local moral worlds of infertile Muslims as they attempt to make, in the religiously correct fashion, Muslim babies at in vitro fertilization (IVF) clinics in Egypt and Lebanon. As early as 1980, authoritative fatwas issued from Egypt's famed Al-Azhar University suggested that IVF and similar technologies are permissible as long as they do not involve any form of third-party donation (of sperm, eggs, embryos, or uteruses). Since the late 1990s, however, divergences in opinion over third-party gamete donation have occurred between Sunni and Shi'ite Muslims, with Iran's leading ayatollah permitting gamete donation under certain conditions. This Iranian fatwa has had profound implications for the country of Lebanon, where a Shi'ite majority also seeks IVF services. Based on three periods of ethnographic research in Egyptian and Lebanese IVF clinics, this paper explores official and unofficial religious discourses surrounding the practice of IVF and third-party donation in the Muslim world, as well as the gender implications of gamete donation for Muslim marriages.

  16. [Biocompatibility of polyethylene imine (PEI)-coated magnetic Fe₃O₄ nanoparticles in SHI-1 cells].

    PubMed

    Chao, Xiao-li; Chen, Zi-xing; Chen, Su-ning; Cen, Jian-nong; Qi, Xiao-fei; Shen, Hong-jie; Yao, Li; Wang, Yuan-yuan

    2013-03-01

    目的 初步探讨利用聚乙烯亚胺包被的四氧化三铁(PEI-Fe₄O₄)磁性纳米颗粒进行磁共振细胞影像技术跟踪细胞生物学行为的可行性。方法 以人急性单核细胞白血病细胞株SHI-1为对象,用透射电镜观察PEI-Fe₄O₄磁性纳米颗粒能否被细胞内吞;用电感耦合等离子发射光谱仪及普鲁士蓝染色观察影响细胞磁性纳米颗粒载量的因素;用CCK-8法检测PEI-Fe₄O₄对SHI-1细胞增殖的影响;用流式细胞术(FCM)检测PEI- Fe₄O₄磁性纳米颗粒对细胞分化的影响;以甲基纤维素半固体培养基培养法检测PEI-Fe₄O₄对细胞集落形成能力的影响。以未经PEI-Fe₄O₄磁性纳米颗粒处理的SHI-1细胞作为对照组。结果 PEI-Fe₄O₄磁性纳米颗粒能成功被SHI-1细胞内吞,细胞内磁性纳米颗粒载量与其起始浓度(以纳米颗粒中的铁离子浓度代表PEI-Fe₄O₄浓度,即μg Fe/ml)及与细胞共培养的时间呈正相关,随细胞分裂传代而减少。以5~100 μg Fe/ml PEI-Fe₄O₄处理细胞,60~100 μg Fe/ml各组对细胞增殖抑制率高于5~50 μg Fe/ml各组,差异具有统计学意义(P<0.05);FCM检测对照组细胞CD11b和CD14分子的表达分别为(78.4±18.5)%和(18.7±2.9)%,佛波醇酯(TPA)处理后增至(92.1±6.5)%和(20.8±2.3)%,PEI-Fe₄O₄标记后的细胞CD11b和CD14分子的表达分别为(83.3±14.2)%和(20.4±2.1)%,TPA处理后增至(95.8±3.3)%、(21.0±6.9)%,实验组和对照组间在TPA处理前后的CD11b和CD14表达差异无统计学意义(P>0.05);0、20、50 μg Fe/ml PEI-Fe₄O₄处理24 h后的SHI-1细胞集落形成率分别为(25.20±7.22)%、(25.93±13.15)%和(23.37±9.33)%,各组间差异无统计学意义(P>0.05)。结论 PEI-Fe₄O₄磁性纳米颗粒可高效率标记SHI-1细胞,在5~50 μg Fe/ml范围内,与SHI-1细胞具有很好的生物相容性,不影响SHI-1细胞的生物学行为,可作

  17. Space Shuttle Cockpit exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Want to sit in the cockpit of the Space Shuttle and watch astronauts work in outer space? At StenniSphere, you can do that and much more. StenniSphere, the visitor center at John C. Stennis Space Center in Hancock County, Miss., presents 14,000-square-feet of interactive exhibits that depict America's race for space as well as a glimpse of the future. StenniSphere is open free of charge from 9 a.m. to 5 p.m. daily.

  18. Starship 2040 Exhibit

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This photograph shows the Starship 2040 on display at Joe Davis Stadium in Huntsville, Alabama. Developed by the Space Transportation Directorate at Marshall Space Flight Center (MSFC), the Starship 2040 exhibit is housed in a 48-ft (14.6-m) tractor and trailer rig, permitting it to travel around the Nation, demonstrating NASA's vision of what commercial spaceflight might be like 40 years from now. All the irnovations suggested aboard the exhibit (automated vehicle health monitoring systems, high-energy propulsion drive, navigational aids, and emergency and safety systems) are based on concepts and technologies now being studied at NASA Centers and partner institutions around the Nation. NASA is the Nation's premier agency for development of the space transportation system, including future-generation reusable launch vehicles. Such systems, the keys to a 'real' Starship 2040, require revolutionary advances in critical aerospace technologies, from thermal, magnetic, chemical, and propellantless propulsion systems to new energy sources such as space solar power or antimatter propulsion. These and other advances are now being studied, developed, and tested at NASA field centers and partner institutions all over the Nation.

  19. pH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins

    PubMed Central

    Koetting, Michael C.; Peppas, Nicholas A.

    2014-01-01

    pH-Responsive hydrogels comprised of itaconic acid copolymerized with N-vinylpyrrolidone (P(IA-co-NVP)) were synthesized and tested as carriers for the oral delivery of high isoelectric point (pI) exhibiting therapeutic proteins. Swelling studies show that P(IA-co-NVP) hydrogels exhibit significantly greater and faster pH-responsive swelling than previously studied methacrylic acid-based hydrogels, achieving up to 68% greater equilibrium swelling and 10.4 times greater swelling in time-limited experiments. Using salmon calcitonin as a model high pI protein therapeutic, we show that P(IA-co-NVP) hydrogels exhibit significantly greater delivery potential than methacrylic acid-based hydrogels. Additionally, we show that utilizing a lower ionic strength solution during drug loading significantly improves drug delivery potential for high pI therapeutics. By using a 1.5 mM PBS buffer rather than the standard 150 mM PBS buffer during loading, up to 83 times as much calcitonin can be delivered in neutral conditions, with up to a 9.6 fold improvement in percent release. Using P(IA-co-NVP) hydrogel microparticles and a low ionic strength loading solution, up to 48 μg calcitonin/mg hydrogel can be delivered in small intestinal conditions. Based on expected absorption in the small intestine, this is sufficient delivery potential for achieving therapeutic dosage via a single, regularly-sized pill taken daily. PMID:24853463

  20. A facility to search for hidden particles at the CERN SPS: the SHiP physics case

    NASA Astrophysics Data System (ADS)

    Alekhin, Sergey; Altmannshofer, Wolfgang; Asaka, Takehiko; Batell, Brian; Bezrukov, Fedor; Bondarenko, Kyrylo; Boyarsky, Alexey; Choi, Ki-Young; Corral, Cristóbal; Craig, Nathaniel; Curtin, David; Davidson, Sacha; de Gouvêa, André; Dell'Oro, Stefano; deNiverville, Patrick; Bhupal Dev, P. S.; Dreiner, Herbi; Drewes, Marco; Eijima, Shintaro; Essig, Rouven; Fradette, Anthony; Garbrecht, Björn; Gavela, Belen; Giudice, Gian F.; Goodsell, Mark D.; Gorbunov, Dmitry; Gori, Stefania; Grojean, Christophe; Guffanti, Alberto; Hambye, Thomas; Hansen, Steen H.; Helo, Juan Carlos; Hernandez, Pilar; Ibarra, Alejandro; Ivashko, Artem; Izaguirre, Eder; Jaeckel, Joerg; Jeong, Yu Seon; Kahlhoefer, Felix; Kahn, Yonatan; Katz, Andrey; Kim, Choong Sun; Kovalenko, Sergey; Krnjaic, Gordan; Lyubovitskij, Valery E.; Marcocci, Simone; Mccullough, Matthew; McKeen, David; Mitselmakher, Guenakh; Moch, Sven-Olaf; Mohapatra, Rabindra N.; Morrissey, David E.; Ovchynnikov, Maksym; Paschos, Emmanuel; Pilaftsis, Apostolos; Pospelov, Maxim; Hall Reno, Mary; Ringwald, Andreas; Ritz, Adam; Roszkowski, Leszek; Rubakov, Valery; Ruchayskiy, Oleg; Schienbein, Ingo; Schmeier, Daniel; Schmidt-Hoberg, Kai; Schwaller, Pedro; Senjanovic, Goran; Seto, Osamu; Shaposhnikov, Mikhail; Shchutska, Lesya; Shelton, Jessie; Shrock, Robert; Shuve, Brian; Spannowsky, Michael; Spray, Andy; Staub, Florian; Stolarski, Daniel; Strassler, Matt; Tello, Vladimir; Tramontano, Francesco; Tripathi, Anurag; Tulin, Sean; Vissani, Francesco; Winkler, Martin W.; Zurek, Kathryn M.

    2016-12-01

    This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (search for hidden particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, τ \\to 3μ and to search for weakly-interacting sub-GeV dark matter candidates. We discuss the evidence for physics beyond the standard model and describe interactions between new particles and four different portals—scalars, vectors, fermions or axion-like particles. We discuss motivations for different models, manifesting themselves via these interactions, and how they can be probed with the SHiP experiment and present several case studies. The prospects to search for relatively light SUSY and composite particles at SHiP are also discussed. We demonstrate that the SHiP experiment has a unique potential to discover new physics and can directly probe a number of solutions of beyond the standard model puzzles, such as neutrino masses, baryon asymmetry of the Universe, dark matter, and inflation.

  1. A facility to search for hidden particles at the CERN SPS: the SHiP physics case.

    PubMed

    Alekhin, Sergey; Altmannshofer, Wolfgang; Asaka, Takehiko; Batell, Brian; Bezrukov, Fedor; Bondarenko, Kyrylo; Boyarsky, Alexey; Choi, Ki-Young; Corral, Cristóbal; Craig, Nathaniel; Curtin, David; Davidson, Sacha; de Gouvêa, André; Dell'Oro, Stefano; deNiverville, Patrick; Bhupal Dev, P S; Dreiner, Herbi; Drewes, Marco; Eijima, Shintaro; Essig, Rouven; Fradette, Anthony; Garbrecht, Björn; Gavela, Belen; Giudice, Gian F; Goodsell, Mark D; Gorbunov, Dmitry; Gori, Stefania; Grojean, Christophe; Guffanti, Alberto; Hambye, Thomas; Hansen, Steen H; Helo, Juan Carlos; Hernandez, Pilar; Ibarra, Alejandro; Ivashko, Artem; Izaguirre, Eder; Jaeckel, Joerg; Jeong, Yu Seon; Kahlhoefer, Felix; Kahn, Yonatan; Katz, Andrey; Kim, Choong Sun; Kovalenko, Sergey; Krnjaic, Gordan; Lyubovitskij, Valery E; Marcocci, Simone; Mccullough, Matthew; McKeen, David; Mitselmakher, Guenakh; Moch, Sven-Olaf; Mohapatra, Rabindra N; Morrissey, David E; Ovchynnikov, Maksym; Paschos, Emmanuel; Pilaftsis, Apostolos; Pospelov, Maxim; Reno, Mary Hall; Ringwald, Andreas; Ritz, Adam; Roszkowski, Leszek; Rubakov, Valery; Ruchayskiy, Oleg; Schienbein, Ingo; Schmeier, Daniel; Schmidt-Hoberg, Kai; Schwaller, Pedro; Senjanovic, Goran; Seto, Osamu; Shaposhnikov, Mikhail; Shchutska, Lesya; Shelton, Jessie; Shrock, Robert; Shuve, Brian; Spannowsky, Michael; Spray, Andy; Staub, Florian; Stolarski, Daniel; Strassler, Matt; Tello, Vladimir; Tramontano, Francesco; Tripathi, Anurag; Tulin, Sean; Vissani, Francesco; Winkler, Martin W; Zurek, Kathryn M

    2016-12-01

    This paper describes the physics case for a new fixed target facility at CERN SPS. The SHiP (search for hidden particles) experiment is intended to hunt for new physics in the largely unexplored domain of very weakly interacting particles with masses below the Fermi scale, inaccessible to the LHC experiments, and to study tau neutrino physics. The same proton beam setup can be used later to look for decays of tau-leptons with lepton flavour number non-conservation, [Formula: see text] and to search for weakly-interacting sub-GeV dark matter candidates. We discuss the evidence for physics beyond the standard model and describe interactions between new particles and four different portals-scalars, vectors, fermions or axion-like particles. We discuss motivations for different models, manifesting themselves via these interactions, and how they can be probed with the SHiP experiment and present several case studies. The prospects to search for relatively light SUSY and composite particles at SHiP are also discussed. We demonstrate that the SHiP experiment has a unique potential to discover new physics and can directly probe a number of solutions of beyond the standard model puzzles, such as neutrino masses, baryon asymmetry of the Universe, dark matter, and inflation.

  2. Understanding Relations among Children's Shy and Antisocial/Aggressive Behaviors and Mothers' Parenting: The Role of Maternal Beliefs

    ERIC Educational Resources Information Center

    Evans, Cortney A.; Nelson, Larry J.; Porter, Christin L.; Nelson, David A.; Hart, Craig H.

    2012-01-01

    This study assesses the relationships between children's shy and antisocial/aggressive behaviors and maternal beliefs, and concomitant parenting behaviors. Structural equation models examined 199 mothers' perceptions of aggression and shyness in their preschool-age children (average age = 59.63 months); maternal beliefs (i.e., locus of control,…

  3. [Ancient needling method--essence of ZHANG Shi-jie: a famous acupuncturist].

    PubMed

    Ma, Xin-Ping; Jiang, Yan

    2014-07-01

    ZHANG Shi-jie is one of the 500 famous TCM doctors designated by the State Administration of TCM and Beijing Municipal Health Bureau. ZHANG advocates ancient needling method and uses a unique treating method which includes comprehensive analysis of the four examinations and analogy; in his ancient treatment, he usually selects few acupoints and prefers Taixi (KI 3), he insists on stopping needling after the harmonious of qi and needling on alternative days; theoretically, ZHANG is versatile and full of learning, he follows the rule of yin and yang and adjusts his ways to cultivate the health; in his treatment, ZHANG considers the patients in diagnosis and treatment and combines the acupuncture with drugs; in teaching, he is strict and rigorous, on one hand, he is ruthless, but on the other hand, he is patient, demonstrating the sincere shining example of great doctors.

  4. Effects of Climate Change and Fisheries Bycatch on Shy Albatross (Thalassarche cauta) in Southern Australia

    PubMed Central

    2015-01-01

    The impacts of climate change on marine species are often compounded by other stressors that make direct attribution and prediction difficult. Shy albatrosses (Thalassarche cauta) breeding on Albatross Island, Tasmania, show an unusually restricted foraging range, allowing easier discrimination between the influence of non-climate stressors (fisheries bycatch) and environmental variation. Local environmental conditions (rainfall, air temperature, and sea-surface height, an indicator of upwelling) during the vulnerable chick-rearing stage, have been correlated with breeding success of shy albatrosses. We use an age-, stage- and sex-structured population model to explore potential relationships between local environmental factors and albatross breeding success while accounting for fisheries bycatch by trawl and longline fisheries. The model uses time-series of observed breeding population counts, breeding success, adult and juvenile survival rates and a bycatch mortality observation for trawl fishing to estimate fisheries catchability, environmental influence, natural mortality rate, density dependence, and productivity. Observed at-sea distributions for adult and juvenile birds were coupled with reported fishing effort to estimate vulnerability to incidental bycatch. The inclusion of rainfall, temperature and sea-surface height as explanatory variables for annual chick mortality rate was statistically significant. Global climate models predict little change in future local average rainfall, however, increases are forecast in both temperatures and upwelling, which are predicted to have detrimental and beneficial effects, respectively, on breeding success. The model shows that mitigation of at least 50% of present bycatch is required to offset losses due to future temperature changes, even if upwelling increases substantially. Our results highlight the benefits of using an integrated modeling approach, which uses available demographic as well as environmental data

  5. Effects of Climate Change and Fisheries Bycatch on Shy Albatross (Thalassarche cauta) in Southern Australia.

    PubMed

    Thomson, Robin B; Alderman, Rachael L; Tuck, Geoffrey N; Hobday, Alistair J

    2015-01-01

    The impacts of climate change on marine species are often compounded by other stressors that make direct attribution and prediction difficult. Shy albatrosses (Thalassarche cauta) breeding on Albatross Island, Tasmania, show an unusually restricted foraging range, allowing easier discrimination between the influence of non-climate stressors (fisheries bycatch) and environmental variation. Local environmental conditions (rainfall, air temperature, and sea-surface height, an indicator of upwelling) during the vulnerable chick-rearing stage, have been correlated with breeding success of shy albatrosses. We use an age-, stage- and sex-structured population model to explore potential relationships between local environmental factors and albatross breeding success while accounting for fisheries bycatch by trawl and longline fisheries. The model uses time-series of observed breeding population counts, breeding success, adult and juvenile survival rates and a bycatch mortality observation for trawl fishing to estimate fisheries catchability, environmental influence, natural mortality rate, density dependence, and productivity. Observed at-sea distributions for adult and juvenile birds were coupled with reported fishing effort to estimate vulnerability to incidental bycatch. The inclusion of rainfall, temperature and sea-surface height as explanatory variables for annual chick mortality rate was statistically significant. Global climate models predict little change in future local average rainfall, however, increases are forecast in both temperatures and upwelling, which are predicted to have detrimental and beneficial effects, respectively, on breeding success. The model shows that mitigation of at least 50% of present bycatch is required to offset losses due to future temperature changes, even if upwelling increases substantially. Our results highlight the benefits of using an integrated modeling approach, which uses available demographic as well as environmental data

  6. Gallium(III), cobalt(III) and copper(II) protoporphyrin IX exhibit antimicrobial activity against Porphyromonas gingivalis by reducing planktonic and biofilm growth and invasion of host epithelial cells.

    PubMed

    Olczak, Teresa; Maszczak-Seneczko, Dorota; Smalley, John W; Olczak, Mariusz

    2012-08-01

    Porphyromonas gingivalis acquires heme for growth, and initiation and progression of periodontal diseases. One of its heme acquisition systems consists of the HmuR and HmuY proteins. This study analyzed the antimicrobial activity of non-iron metalloporphyrins against P. gingivalis during planktonic growth, biofilm formation, epithelial cell adhesion and invasion, and employed hmuY, hmuR and hmuY-hmuR mutants to assess the involvement of HmuY and HmuR proteins in the acquisition of metalloporphyrins. Iron(III) mesoporphyrin IX (mesoheme) and iron(III) deuteroporphyrin IX (deuteroheme) supported planktonic growth of P. gingivalis cells, biofilm accumulation, as well as survival, adhesion and invasion of HeLa cells in a way analogous to protoheme. In contrast, cobalt(III), gallium(III) and copper(II) protoporphyrin IX exhibited antimicrobial activity against P. gingivalis, and thus represent potentially useful antibacterial compounds with which to target P. gingivalis. P. gingivalis hmuY, hmuR and hmuY-hmuR mutants showed decreased growth and infection of epithelial cells in the presence of all metalloporphyrins examined. In conclusion, the HmuY protein may not be directly involved in transport of free metalloporphyrins into the bacterial cell, but it may also play a protective role against metalloporphyrin toxicity by binding an excess of these compounds.

  7. [Synthesis and characterization of complex of Na2[Cu5(Shi)4].4H2O].

    PubMed

    Yang, Bin-sheng; Hu, Yong-gang; Chen, Zhao-bin; Liu, Wen

    2002-12-01

    The complex, which is formed by reacting copper (II) with salicylhydroxamic acid (H3Shi), has been synthesized. The chemical formula of the complex was determined to be Na2[Cu5(Shi)4].4H2O by elemental analysis and spectrometric titration. The structure and the properties were tentatively investigated by using UV-Vis, IR, NMR, TG, fluorescence, molecular modeling and magnetic susceptibility measurement. The results show that the UV absorption peak corresponding to the pi-->pi* transition shifts towards red 25 nm, the d proton of salicylhydroxamic acid behaves as that of alkyl hydrocarbon in NMR and there is a strong magnetic interaction among the copper (II) ions in the complex.

  8. Structural and magnetic properties studies on swift heavy ion (SHI) irradiated Fe3O4 thin films

    NASA Astrophysics Data System (ADS)

    Sun, Jianrong; Wang, Zhiguang; Wang, Yuyu; Zhu, Yabin; Pang, Lilong; Shen, Tielong; Li, Fashen

    2012-09-01

    Polycrystalline Fe3O4 thin films are synthesized at low temperature by electroless plating, and the effects of irradiation by Kr26+ ions at energy of 2.03 GeV on the magnetic properties of the Fe3O4 thin films are investigated by macroscopic magnetization measurements (vibrating sample magnetometer, VSM; superconducting quantum interference device, SQUID) and microscopic distribution of the magnetic moments (conversion electron mössbauer spectroscopy, CEMS) as well as magnetic domain structure (magnetic force microscope, MFM) analyses. The initial crystallographic structure of the Fe3O4 remains unaffected after swift heavy ion (SHI) irradiation at low damage levels, but VSM, CEMS and MFM results indicate that SHI irradiation is an effectual tool to not only modify the macro-magnetic properties (saturation magnetization, coercivity, etc.), but also modify the micro-magnetic properties (magnetic anisotropy, distribution of the magnetic moments, magnetic domain structure, etc.) significantly. And all modifications of these properties could be interpreted very well by the effects related to the stress and defects (the production, accumulation and free) induced by SHI irradiation.

  9. SHI induced enhancement in conductivity of PbTe thin film for thermoelectric applications

    SciTech Connect

    Gupta, Srashti; Agarwal, D. C.; Singh, J. P.; Tripathi, S. K.; Neeleshwar, S.; Asokan, K.; Panigrahi, B. K.; Avasthi, D. K.

    2012-06-05

    PbTe thin film were synthesized using thermal evaporation and irradiated by 100 MeV Ag ions at different fluences ranging from 3x10{sup 13} and 1x10{sup 14} ions/cm{sup 2}. Pristine films annealed under Ar atm at 250 deg. C for 1 hr. X-ray Diffraction (XRD) of pristine and irradiated films reveals the improvement of PbTe phase with increasing fluence. The thickness of the film is decreased from 195 nm to 150 nm after ion irradiation as indicated by Rutherford backscattering spectrometry (RBS) analysis due to the sputtering. Resistivity measurement using four probe techniques of these films shows the conductivity enhancement with ion fluence. The conductivity is found to be {approx} 6 fold at fluence 3x10{sup 13} ions/cm{sup 2} whereas it decreases to 3 fold after annealing in comparison to pristine sample. On further increasing the fluence from 3x10{sup 13} ions/cm{sup 2}, the properties of the film begin to deteriorate. SHI induced modification may be explained on the basis of oxygen desorption and change in stochiometry of film during irradiation.

  10. Mechanosensitivity below Ground: Touch-Sensitive Smell-Producing Roots in the Shy Plant Mimosa pudica.

    PubMed

    Musah, Rabi A; Lesiak, Ashton D; Maron, Max J; Cody, Robert B; Edwards, David; Fowble, Kristen L; Dane, A John; Long, Michael C

    2016-02-01

    The roots of the shy plant Mimosa pudica emit a cocktail of small organic and inorganic sulfur compounds and reactive intermediates into the environment, including SO2, methanesulfinic acid, pyruvic acid, lactic acid, ethanesulfinic acid, propanesulfenic acid, 2-aminothiophenol, S-propyl propane 1-thiosulfinate, phenothiazine, and thioformaldehyde, an elusive and highly unstable compound that, to our knowledge, has never before been reported to be emitted by a plant. When soil around the roots is dislodged or when seedling roots are touched, an odor is detected. The perceived odor corresponds to the emission of higher amounts of propanesulfenic acid, 2-aminothiophenol, S-propyl propane 1-thiosulfinate, and phenothiazine. The mechanosensitivity response is selective. Whereas touching the roots with soil or human skin resulted in odor detection, agitating the roots with other materials such as glass did not induce a similar response. Light and electron microscopy studies of the roots revealed the presence of microscopic sac-like root protuberances. Elemental analysis of these projections by energy-dispersive x-ray spectroscopy revealed them to contain higher levels of K(+) and Cl(-) compared with the surrounding tissue. Exposing the protuberances to stimuli that caused odor emission resulted in reductions in the levels of K(+) and Cl(-) in the touched area. The mechanistic implications of the variety of sulfur compounds observed vis-à-vis the pathways for their formation are discussed.

  11. Development and validation of the Shy Bladder and Bowel Scale (SBBS)

    PubMed Central

    Knowles, Simon R.; Skues, Jason

    2016-01-01

    Abstract Currently research exploring paruresis and parcopresis, anxiety relating to urinating and having bowel motions in public respectively is limited. While there are several validated measures of paruresis, no valid measure assessing parcopresis is currently available. The present study investigates the development and validation of the Shy Bladder and Bowel Scale (SBBS) which assesses both paruresis and parcopresis. Two participant groups were utilised to validate this scale, a student psychology cohort (n = 387) and a public cohort (n = 334). An eight-item two-factor model was identified in the psychology cohort and confirmed in the public cohort. The two-factor SBBS was found to be a valid and reliable measure of paruresis and parcopresis. Paruresis and parcopresis-related concerns were associated with social anxiety in both cohorts. Subscales for both paruresis and parcopresis (i.e. difficulty, interference and distress) were positively correlated, suggesting individuals are likely to report similar levels of concerns across both conditions. Further, individuals self-identifying with either paruresis or parcopresis reported significantly higher scores on the respective SBBS subscales than non-identifying paruresis and parcopresis individuals. The SBBS also demonstrated strong test–retest reliability in a small sample of adults (n = 13). Overall, the developed scale provides clinicians and researchers with a valuable tool to evaluate both paruresis and parcopresis. PMID:27216857

  12. The variation of riverbed material due to tropical storms in Shi-Wen River, Taiwan.

    PubMed

    Lin, Chin-Ping; Wang, Yu-Min; Tfwala, Samkele S; Chen, Ching-Nuo

    2014-01-01

    Taiwan, because of its location, is a flood prone region and is characterised by typhoons which brings about two-thirds to three quarters of the annual rainfall amount. Consequently, enormous flows result in rivers and entrain some fractions of the grains that constitute the riverbed. Hence, the purpose of the study is to quantify the impacts of these enormous flows on the distribution of grain size in riverbeds. The characteristics of riverbed material prior to and after the typhoon season are compared in Shi-Wen River located at southern Taiwan. These include grain size variation, bimodality, and roughness coefficient. A decrease (65%) and increase (50%) in geometric mean size of grains were observed for subsurface and surface bed material, respectively. Geometric standard deviation decreased in all sites after typhoon. Subsurface material was bimodal prior to typhoons and polymodal after. For surface material, modal class is in the gravel class, while after typhoons it shifts towards cobble class. The reduction in geometric mean resulted to a decrease in roughness coefficient by up to 30%. Finally, the relationship of Shields and Froude numbers are studied and a change in the bed form to antidunes and transition form is observed, respectively.

  13. [Essence of professor SHI Xin-de's experience in application of persicae ramulus-associated prescriptions].

    PubMed

    Du, Xin-Liang

    2014-07-01

    Persicae Ramulus decoction, as the first prescription in Treatise on febrile Diseases, has been recommended by physicians of successive generations. It is also the general prescription for harmonizing yingfen and weifen, yin and yang, qi and blood. Although it only consists of five herbal medicines, it has a wider range of application and more categorized formulas than other prescriptions. Though Persicae Ramulus decoction was originally formulated to treat taiyang apoplexy, it has functions beyond the treatment of exopathic diseases. This formula is also effective in treating internal diseases, surgical diseases, gynecologic diseases, paediatric diseases, etc. KE Yun-bo praised it as the No. 1 formula among ZHANG Zhong-jin's formulas as well as the general prescription for harmonizing Yin and Yang, yingfen and weifen, resolving fleshy exterior and inducing perspiration. Professor SHI Xin-de has been expert at treating intractable diseases by using Persicae Ramulus-associated prescriptions, such as Xiaojianzhong decoction and Baohe pill for children's chronic eczema, Persicae Ramulus and Puerariae Lobatae Radix decoction and Yupingfeng powder for chronic nephritis, and Persicae Ramulus and Longgu Muli decoction for insomnia. Instead of being restricted to Chinese or Western disease names, he prescribed appropriate formulas according to syndromes, thereby achieving a good efficacy.

  14. Amino acid composition, petrology, geochemistry, 14C terrestrial age and oxygen isotopes of the Shişr 033 CR chondrite

    NASA Astrophysics Data System (ADS)

    Martins, Z.; Hofmann, B. A.; Gnos, E.; Greenwood, R. C.; Verchovsky, A.; Franchi, I. A.; Jull, A. J. T.; Botta, O.; Glavin, D. P.; Dworkin, J. P.; Ehrenfreund, P.

    We have analyzed Shişr 033, a CR chondrite from the Omani desert, using several different analytical techniques designed to study the degree of terrestrial alteration of this meteorite and also its petrologic classification. Bulk chemical analyses (including organic carbon and mean total H2O content) are consistent with a CR classification. Additionally, oxygen isotope analysis on a bulk sample indicates that Shişr 033 is of type CR2. Amino acid analysis using liquid chromatography with UV fluorescence detection (HPLC-FD) and liquid chromatography-time of flight-mass spectrometry (LC-ToF-MS) show that the absolute and the relative amino acid content of Shişr 033 is distinct from other carbonaceous chondrites. Oxygen isotope analysis of a phyllosilicate-rich dark inclusion shows that this inclusion is closer to CV3 or CO3 chondrites. The effects of terrestrial weathering in Shişr 033 are evident from the dark inclusion carbon isotopic data, bulk chemistry (through the elevated concentrations of Sr and Ba), and amino acid data, which suggests extensive amino acid contamination of the meteorite from the fall site soil. Nevertheless, Shişr 033 contains a small fraction of indigenous components, as indicated by the presence of the extraterrestrial amino acid α-aminoisobutyric acid (AIB) that was not detected in the Shişr soils. Finally, the terrestrial age of Shişr 033 was determined and is discussed in the context of high levels of contamination.

  15. Traveling Exhibitions: translating current science into effective science exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.; Morrow, C.; Harold, J.

    The Space Science Institute (SSI) of Boulder, Colorado has recently developed two museum exhibits called the Space Weather Center and MarsQuest. It is currently planning to develop two other exhibitions called Cosmic Origins and InterActive Earth. Museum exhibitions provide research scientists the opportunity to engage in a number of activities that are vital to the success of earth and space outreach programs. The Space Weather Center was developed in partnership with various research missions at NASA's Goddard Space Flight Center. The focus of the presentation will be on the Institute's MarsQuest exhibition. This project is a 5000 square-foot, 2.5M, traveling exhibition that is now touring the country. The exhibit's 3-year tour is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and learn more about their own planet in the process. The associated planetarium show and education program will also be described, with particular emphasis on workshops to orient host museum staff (e.g. museum educators and docents). The workshops make innovative connections between the exhibitions interactive experiences and lesson plans aligned with the National Science Education Standards. SSI is also developing an interactive web site called MarsQuest On-line. The linkage between the web site, education program and exhibit will be discussed. MarsQuest and SSI's other exhibitions are good models for actively involving scientists and their discoveries to help improve informal science education in the museum community and for forging a stronger connection between formal and informal education.

  16. Pragmatists, Positive Communicators, and Shy Enthusiasts: Three Viewpoints on Web Conferencing in Health Sciences Education

    PubMed Central

    Akhtar-Danesh, Noori; Eva, Kevin; Levinson, Anthony; Wainman, Bruce

    2007-01-01

    Background Web conferencing is a synchronous technology that allows coordinated online audio and visual interactions with learners logged in to a central server. Recently, its use has grown rapidly in academia, while research on its use has not kept up. Conferencing systems typically facilitate communication and support for multiple presenters in different locations. A paucity of research has evaluated synchronous Web conferencing in health sciences education. Objective McMaster University Faculty of Health Sciences trialed Wimba’s Live Classroom Web conferencing technology to support education and curriculum activities with students and faculty. The purpose of this study was to explore faculty, staff, and student perceptions of Web conferencing as a support for teaching and learning in health sciences. The Live Classroom technology provided features including real-time VoIP audio, an interactive whiteboard, text chat, PowerPoint slide sharing, application sharing, and archiving of live conferences to support student education and curriculum activities. Methods Q-methodology was used to identify unique and common viewpoints of participants who had exposure to Web conferencing to support educational applications during the trial evaluation period. This methodology is particularly useful for research on human perceptions and interpersonal relationships to identify groups of participants with different perceptions. It mixes qualitative and quantitative methods. In a Q-methodology study, the goal is to uncover different patterns of thought rather than their numerical distribution among the larger population. Results A total of 36 people participated in the study, including medical residents (14), nursing graduate students (11), health sciences faculty (9), and health sciences staff (2). Three unique viewpoints were identified: pragmatists (factor 1), positive communicators (factor 2A), and shy enthusiasts (factor 2B). These factors explained 28% (factor 1) and 11

  17. Violence against women in the context of war: experiences of Shi'i women and Palestinian refugee women in Lebanon.

    PubMed

    Holt, Maria

    2013-03-01

    In times of war, women are likely to experience, in addition to the "normal" violence of peacetime, random cruelties perpetrated by the enemy against all members of the community. During research conducted with Palestinian refugees and Shi'i Muslims in Lebanon, women described various forms of violence and, in this article, I examine violence suffered by women in the context of conflict from three perspectives: victimization, trauma, and resistance. I argue that traumatic events have the effect of obliterating identity, but they can also strengthen the resolve to resist.

  18. Brain stem auditory evoked potentials in patients with multiple system atrophy with progressive autonomic failure (Shy-Drager syndrome).

    PubMed Central

    Prasher, D; Bannister, R

    1986-01-01

    Brain stem potentials from three groups of patients, namely those with pure progressive autonomic failure, Parkinson's disease and multisystem atrophy with progressive autonomic failure (Shy-Drager syndrome) were compared with each other and a group of normal subjects. In virtually all the patients with multisystem atrophy with progressive autonomic failure the brain stem potentials were abnormal in contrast to normal findings with Parkinson's disease. The closely associated group of patients with progressive autonomic failure alone also revealed no abnormalities of the BAEP. This separation of the two groups, Parkinson's disease and progressive autonomic failure from multisystem atrophy with progressive autonomic failure is important clinically as multiple system atrophy of the Shy-Drager type has extra-pyramidal features closely resembling Parkinsonism or a late onset cerebellar degeneration. From the abnormalities of the brain stem response in multisystem atrophy with progressive autonomic failure, it is clear that some disruption of the auditory pathway occurs in the ponto-medullary region as in nearly all patients there is a significant delay or reduction in the amplitude of components of the response generated beyond this region. The most likely area involved is the superior olivary complex. Images PMID:3958741

  19. Direct determination of the number of electrons needed to reduce coenzyme F430 pentamethyl ester to the Ni(I) species exhibiting the electron paramagnetic resonance and ultraviolet-visible spectra characteristic for the MCR(red1) state of methyl-coenzyme M reductase.

    PubMed

    Piskorski, Rafal; Jaun, Bernhard

    2003-10-29

    The UV-visible and electron paramagnetic resonance (EPR) spectra of MCR(red1), the catalytically active state of methyl-coenzyme M reductase, are almost identical to those observed when free coenzyme F430 or its pentamethyl ester (F430M) are reduced to the Ni(I) valence state. Investigations and proposals concerning the catalytic mechanism of MCR were therefore based on MCR(red1) containing Ni(I)F430 until, in a recent report, Tang et al. (J. Am. Chem. Soc. 2002, 124, 13242) interpreted their resonance Raman data and titration experiments as indicating that, in MCR(red1), coenzyme F430 is not only reduced at the nickel center but at one of the C=N double bonds of the hydrocorphinoid macrocycle as well. To resolve this contradiction, we have investigated the stoichiometry of the reduction of coenzyme F430 pentamethyl ester (F430M) by three independent methods. Spectroelectrochemistry showed clean reduction to a single product that exhibits the UV-vis spectrum typical for MCR(red1). In three bulk electrolysis experiments, 0.96 +/- 0.1 F/mol was required to generate the reduced species. Reduction with decamethylcobaltocene in tetrahydrofuran (THF) consumed 1 mol of (Cp)(2)Co/mol of F430M, and the stoichiometry of the reoxidation of the reduced form with the two-electron oxidant methylene blue was 0.46 +/- 0.05 mol of methylene blue/mol of reduced F430M. These experiments demonstrate that the reduction of coenzyme F430M to the species having almost identical UV-vis and EPR spectra as MCR(red1) is a one-electron process and therefore inconsistent with a reduction of the macrocycle chromophore.

  20. A Polarized Light Microscopic Study to Comparatively evaluate Four Remineralizing Agents on Enamel viz CPP-ACPF, ReminPro, SHY-NM and Colgate Strong Teeth

    PubMed Central

    Krishnan, Ramesh; Bhaskaran, Bibin; Kumar, Suresh V

    2015-01-01

    ABSTRACT Aim: To compare and evaluate the remineralizing potential of four commercially available products namely SHY-NM, GC Tooth Mousse Plus, ReminPro and Colgate strong teeth on demineralized human teeth. Materials and methods: The study included 50 extracted premolars having 3 × 3 mm window prepared on the middle third of the tooth, which was then subjected to demineralization for 48 hours at 37°C. Teeth were randomly selected and grouped into five study groups of 10 teeth in each. Each group was treated with respective remineralizing agent and sectioned using hard-tissue microtome. Each section obtained was visualized under polarized light microscope and analyzed using Image J software. Results: The statistically evaluated results revealed that SHY-NM has the most remineralizing potential followed by ReminPro, GC Tooth Mousse Plus and fluoridated toothpaste. Conclusion: Based on the study, the SHY-NM was superior to the GC Tooth Mousse Plus, ReminPro and Colgate strong teeth on demineralized human teeth. How to cite this article: Rajan R, Krishnan R, Bhaskaran B, Kumar SV. A Polarized Light Microscopic Study to Comparatively evaluate Four Remineralizing Agents on Enamel viz CPP-ACPF, ReminPro, SHY-NM and Colgate Strong Teeth. Int J Clin Pediatr Dent 2015;8(1):42-47. PMID:26124580

  1. High-Quality Draft Genome Sequence of Low-pH-Active Veillonella parvula Strain SHI-1, Isolated from Human Saliva within an In Vitro Oral Biofilm Model.

    PubMed

    Edlund, Anna; Liu, Quanhui; Watling, Michael; To, Thao T; Bumgarner, Roger E; He, Xuesong; Shi, Wenyuan; McLean, Jeffrey S

    2016-02-18

    We announce here a draft genome sequence of Veillonella parvula strain SHI-1, obtained from healthy human saliva, discovered to be active at low pH using metatranscriptomics within an in vitro oral biofilm model. The genome is composed of 7 contigs, for a total of 2,200,064 bp.

  2. Thermoelectric device exhibiting decreased stress

    SciTech Connect

    Heath, D.L.; Chou, D.J.

    1985-02-05

    A thermoelectric device exhibiting both structural integrity and decreased stress across the device notwithstanding the application of thermally cycled temperature differentials thereacross includes, electrically interconnected thermoelectric elements and a rigidly affixed substrate. Thermal stress is relieved by using flexible conductors to interconnect the thermoelectric elements, and by the use of a flexile joint to attach a second substrate to the remainder of the device. Complete elimination of the second substrate may also be used to eliminate stress. Presence of the rigidly affixed substrate gives the device sufficient structural integrity to enable it to withstand rugged conditions.

  3. Large holograms in traveling exhibitions

    NASA Astrophysics Data System (ADS)

    Christakis, Anne-Marie

    1994-01-01

    The presentation of large holograms in travelling exhibitions has always posed problems, mainly due to lack of space. The Museum of Holography was consequently required to develop, with Jean-Francois Moreau, display consoles which are light, affordable and completely detachable. In a permanent exposition at the Forum des Halles in Paris, the Museum displays a room with 22 holograms, each measuring 1 m X 1 m, in a structure designed by the architect Fabien Vienne. The different systems used by the Museum are presented here.

  4. SHiP: a new facility to search for heavy neutrinos and study ντ properties

    NASA Astrophysics Data System (ADS)

    De Serio, M.; SHiP Collaboration

    2016-05-01

    SHiP (Search for Hidden Particles) is a newly designed fixed target facility, proposed at the CERN SPS accelerator, with the aim of complementing searches for New Physics at LHC by searching for light long-lived exotic particles with masses below a few GeV/c2. The sensitivity to Heavy Neutrinos will allow for the first time probing a region of the parameter space where Baryogenesis and active neutrino masses and oscillation could also be explained. A dedicated detector, based on OPERA-like bricks, will provide the first observation of the tau anti-neutrino. Moreover, ντ and ν¯τ cross-sections will be measured with a statistics 1000 times larger than currently available data and will allow extracting the F4 and F5 structure functions, never measured so far. Charm physics studies will be performed with significantly improved accuracy with respect to past experiments.

  5. Collaborative virtual environments art exhibition

    NASA Astrophysics Data System (ADS)

    Dolinsky, Margaret; Anstey, Josephine; Pape, Dave E.; Aguilera, Julieta C.; Kostis, Helen-Nicole; Tsoupikova, Daria

    2005-03-01

    This panel presentation will exhibit artwork developed in CAVEs and discuss how art methodologies enhance the science of VR through collaboration, interaction and aesthetics. Artists and scientists work alongside one another to expand scientific research and artistic expression and are motivated by exhibiting collaborative virtual environments. Looking towards the arts, such as painting and sculpture, computer graphics captures a visual tradition. Virtual reality expands this tradition to not only what we face, but to what surrounds us and even what responds to our body and its gestures. Art making that once was isolated to the static frame and an optimal point of view is now out and about, in fully immersive mode within CAVEs. Art knowledge is a guide to how the aesthetics of 2D and 3D worlds affect, transform, and influence the social, intellectual and physical condition of the human body through attention to psychology, spiritual thinking, education, and cognition. The psychological interacts with the physical in the virtual in such a way that each facilitates, enhances and extends the other, culminating in a "go together" world. Attention to sharing art experience across high-speed networks introduces a dimension of liveliness and aliveness when we "become virtual" in real time with others.

  6. Understanding Iraq’s Shi’is: Evolving Misperceptions within the U.S. Government from the 1970s to the Present

    DTIC Science & Technology

    2005-06-01

    NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited UNDERSTANDING IRAQ� S SHI...AGENCY USE ONLY (Leave blank) 2. REPORT DATE June 2005 3. REPORT TYPE AND DATES COVERED Master� s Thesis 4. TITLE AND SUBTITLE: Understanding...Iraq� s Shi�is: Evolving Misperceptions Within the U.S. Government From the 1970� s to the Present. 6. AUTHOR( S ) Mizell, Daron M. 5. FUNDING NUMBERS

  7. Muscle development and body growth in larvae and early post-larvae of shi drum, Umbrina cirrosa L., reared under different larval photoperiod: muscle structural and ultrastructural study.

    PubMed

    Ayala, Maria D; Abellán, Emilia; Arizcun, Marta; García-Alcázar, Alicia; Navarro, F; Blanco, Alfonso; López-Albors, Octavio M

    2013-08-01

    Shi drum specimens were maintained under four different photoperiod regimes: a natural photoperiod regime (16L:8D), constant light (24L), equal durations of light and dark (12L:12D) and a reduced number of daylight hours (6L:18D) from hatching until the end of larval metamorphosis. Specimens were then kept under natural photoperiod conditions until 111 days post-hatching. Muscle and body parameters were studied. During the vitelline phase, there was little muscle growth and no photoperiod effects were reported; however, a monolayer of red muscle and immature white muscle fibres were observed in the myotome. At hatching, external cells (presumptive myogenic cells) were already present on the surface of the red muscle. At the mouth opening, some presumptive myogenic cells appeared between the red and white muscles. At 20 days, new germinal areas were observed in the apical extremes of the myotome. At this stage, the 16L:8D group (followed by the 24L group) had the longest body length, the largest cross-sectional area of white muscle and the largest white muscle fibres. Conversely, white muscle hyperplasia was most pronounced in the 24L group. Metamorphosis was complete at 33 days in the 24L and 12L:12D groups. At this moment, both groups showed numerous myogenic precursors on the surface of the myotome as well as among the adult muscle fibres (mosaic hyperplastic growth). The 16L:8D group completed metamorphosis at 50 days, showing a similar degree of structural maturity in the myotome to that described in the 24L and 12L:12D groups at 33 days. When comparing muscle growth at the end of the larval period, hypertrophy was highest in the 16L:8D group, whereas hyperplasia was higher in the 24L and 16L:8D groups. At 111 days, all groups showed the adult muscle pattern typical of teleosts; however, the cross-sectional area of white muscle, white muscle fibre hyperplasia, body length and body weight were highest in the 24L group, followed by the 12L:12D group; white muscle

  8. Exhibits Enhanced by Stand-Alone Computers.

    ERIC Educational Resources Information Center

    Van Rennes, Eve C.

    Both the development and evaluation of one of a set of computer programs designed for use by visitors as adjuncts to museum exhibits are described. Museum displays used were (1) a static, behind-glass exhibit on evolution; (2) a hands-on primitive stone age tools exhibit; and (3) a Foucault pendulum. A computer placed next to each exhibit served…

  9. Intertidal pool fish Girella laevifrons (Kyphosidae) shown strong physiological homeostasis but shy personality: The cost of living in hypercapnic habitats.

    PubMed

    Benítez, S; Duarte, C; Opitz, T; Lagos, N A; Pulgar, J M; Vargas, C A; Lardies, M A

    2017-02-16

    Tide pools habitats are naturally exposed to a high degree of environmental variability. The consequences of living in these extreme habitats are not well established. In particular, little it is known about of the effects of hypercanic seawater (i.e. high pCO2 levels) on marine vertebrates such as intertidal pool fish. The aim of this study was to evaluate the effects of increased pCO2 on the physiology and behavior in juveniles of the intertidal pool fish Girella laevifrons. Two nominal pCO2 concentrations (400 and 1600μatm) were used. We found that exposure to hypercapnic conditions did not affect oxygen consumption and absorption efficiency. However, the lateralization and boldness behavior was significantly disrupted in high pCO2 conditions. In general, a predator-risk cost of boldness is assumed, thus the increased occurrence of shy personality in juvenile fishes may result in a change in the balance of this biological interaction, with significant ecological consequences.

  10. NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models.

    PubMed

    Ito, M; Kobayashi, K; Nakahata, T

    2008-01-01

    "Humanized mice," in which various kinds of human cells and tissues can be engrafted and retain the same functions as in humans, are extremely useful because human diseases can be studied directly. Using the newly combined immunodeficient NOD-scid IL2rgamma(null) mice and Rag2(null) IL2rgamma(null) humanized mice, it has became possible to expand applications because various hematopoietic cells can be differentiated by human hematopoietic stem cell transplantation, and the human immune system can be reconstituted to some degree. This work has attracted attention worldwide, but the development and use of immunodeficient mice in Japan are not very well known or understood. This review describes the history and characteristics of the NOD/Shi-scid IL2rgamma(null) (NOG) and BALB/cA-Rag2(null) IL2rgamma(null) mice that were established in Japan, including our unpublished data from researchers who are currently using these mice. In addition, we also describe the potential development of new immunodeficient mice that can be used as humanized mice in the future.

  11. Mechanosensitivity below Ground: Touch-Sensitive Smell-Producing Roots in the Shy Plant Mimosa pudica1[OPEN

    PubMed Central

    Musah, Rabi A.; Lesiak, Ashton D.; Maron, Max J.; Edwards, David; Fowble, Kristen L.; Long, Michael C.

    2016-01-01

    The roots of the shy plant Mimosa pudica emit a cocktail of small organic and inorganic sulfur compounds and reactive intermediates into the environment, including SO2, methanesulfinic acid, pyruvic acid, lactic acid, ethanesulfinic acid, propanesulfenic acid, 2-aminothiophenol, S-propyl propane 1-thiosulfinate, phenothiazine, and thioformaldehyde, an elusive and highly unstable compound that, to our knowledge, has never before been reported to be emitted by a plant. When soil around the roots is dislodged or when seedling roots are touched, an odor is detected. The perceived odor corresponds to the emission of higher amounts of propanesulfenic acid, 2-aminothiophenol, S-propyl propane 1-thiosulfinate, and phenothiazine. The mechanosensitivity response is selective. Whereas touching the roots with soil or human skin resulted in odor detection, agitating the roots with other materials such as glass did not induce a similar response. Light and electron microscopy studies of the roots revealed the presence of microscopic sac-like root protuberances. Elemental analysis of these projections by energy-dispersive x-ray spectroscopy revealed them to contain higher levels of K+ and Cl− compared with the surrounding tissue. Exposing the protuberances to stimuli that caused odor emission resulted in reductions in the levels of K+ and Cl− in the touched area. The mechanistic implications of the variety of sulfur compounds observed vis-à-vis the pathways for their formation are discussed. PMID:26661932

  12. Cumulative approaches to track formation under swift heavy ion (SHI) irradiation: Phenomenological correlation with formation energies of Frenkel pairs

    NASA Astrophysics Data System (ADS)

    Crespillo, M. L.; Agulló-López, F.; Zucchiatti, A.

    2017-03-01

    An extensive survey for the formation energies of Frenkel pairs, as representative candidates for radiation-induced point defects, is presented and discussed in relation to the cumulative mechanisms (CM) of track formation in dielectric materials under swift heavy ion (SHI) irradiation. These mechanisms rely on the generation and accumulation of point defects during irradiation followed by collapse of the lattice once a threshold defect concentration is reached. The physical basis of those approaches has been discussed by Fecht as a defect-assisted transition to an amorphous phase. Although a first quantitative analysis of the CM model was previously performed for LiNbO3 crystals, we have, here, adopted a broader phenomenological approach. It explores the correlation between track formation thresholds and the energies for Frenkel pair formation for a broad range of materials. It is concluded that the threshold stopping powers can be roughly scaled with the energies required to generate a critical Frenkel pair concentration in the order of a few percent of the total atomic content. Finally, a comparison with the predictions of the thermal spike model is discussed within the analytical Szenes approximation.

  13. Learning by Doing, Creating a Museum Exhibit.

    ERIC Educational Resources Information Center

    Main, Sarah; Kallquist, Dierdre

    2000-01-01

    Describes an exhibit called Kid's Kitchen, built within a major exhibit called Biodiversity: Life Supporting Life, in order to discuss environmental prompts hidden within the kitchen designed to surprise students and get them thinking. (ASK)

  14. Science Education Through a Museum Exhibit

    ERIC Educational Resources Information Center

    Chaparian, Azad; And Others

    1973-01-01

    Describes the polywater exhibit at the Worcester Science Center in Massachusetts. Curiosity and interest are stimulated in young people by allowing them to handle the materials in the exhibit and by providing them with instructions for making polywater. (JR)

  15. 29 CFR 2200.70 - Exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... prohibits its convenient transportation and storage. A party may offer into evidence photographs, models or... separate file designated for rejected exhibits. (e) Return of physical exhibits. A party may on motion request the return of a physical exhibit within 30 days after expiration of the time for filing a...

  16. Influence of SHI upon nanohole free volume and micro scale level surface modifications of polyethyleneterephthalate polymer films

    NASA Astrophysics Data System (ADS)

    Kumar, Rajesh; Singh, Paramjit

    2015-05-01

    Topographic micro scale and in-depth nano scale level modifications of polymeric materials play an important role in engineering their physical and chemical properties. Polyethylene terephthalate (PET) is an important class of semi-crystalline polymers used for gas separation properties. The gas diffusion and permeability parameters are directly related to the free volume fractions and the hole distributions. The controlled and precise ion beam irradiation can be used to induce surface and in-depth modifications in the properties of the polymers which help in modifying free volume holes and their distributions. In the present study, the investigation of free volume (nano scale level) and surface (micro scale level) properties of PET polymeric thin films after SHI treatment were employed by means of positron annihilation lifetime spectroscopy (PALS) and atomic force microscopy (AFM), respectively. The PET thin films were irradiated by 50 MeV lithium ions as a function of ion fluence. The value of hole radius (R) and intensity (I3) of o-Ps were observed to be increased after ion beam treatment. The further analyses were employed to calculate the free volume and fractional free volume of holes from the obtained values of R and I3. The AFM studies reveal the surface modifications of the irradiated polymer films. The structural, optical and chemical properties were investigated by X-ray diffraction (XRD), UV-visible (UV-vis) and Fourier transform infrared (FTIR) spectrophotometry. Different parameters such as crystallite size and band gap energy were calculated from the obtained data of XRD and UV-vis, respectively.

  17. Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature.

    PubMed

    Abou Jamra, Rami; Philippe, Orianne; Raas-Rothschild, Annick; Eck, Sebastian H; Graf, Elisabeth; Buchert, Rebecca; Borck, Guntram; Ekici, Arif; Brockschmidt, Felix F; Nöthen, Markus M; Munnich, Arnold; Strom, Tim M; Reis, Andre; Colleaux, Laurence

    2011-06-10

    Intellectual disability inherited in an autosomal-recessive fashion represents an important fraction of severe cognitive-dysfunction disorders. Yet, the extreme heterogeneity of these conditions markedly hampers gene identification. Here, we report on eight affected individuals who were from three consanguineous families and presented with severe intellectual disability, absent speech, shy character, stereotypic laughter, muscular hypotonia that progressed to spastic paraplegia, microcephaly, foot deformity, decreased muscle mass of the lower limbs, inability to walk, and growth retardation. Using a combination of autozygosity mapping and either Sanger sequencing of candidate genes or next-generation exome sequencing, we identified one mutation in each of three genes encoding adaptor protein complex 4 (AP4) subunits: a nonsense mutation in AP4S1 (NM_007077.3: c.124C>T, p.Arg42(∗)), a frameshift mutation in AP4B1 (NM_006594.2: c.487_488insTAT, p.Glu163_Ser739delinsVal), and a splice mutation in AP4E1 (NM_007347.3: c.542+1_542+4delGTAA, r.421_542del, p.Glu181Glyfs(∗)20). Adaptor protein complexes (AP1-4) are ubiquitously expressed, evolutionarily conserved heterotetrameric complexes that mediate different types of vesicle formation and the selection of cargo molecules for inclusion into these vesicles. Interestingly, two mutations affecting AP4M1 and AP4E1 have recently been found to cause cerebral palsy associated with severe intellectual disability. Combined with previous observations, these results support the hypothesis that AP4-complex-mediated trafficking plays a crucial role in brain development and functioning and demonstrate the existence of a clinically recognizable syndrome due to deficiency of the AP4 complex.

  18. Space exhibitions: the science encounters the public

    NASA Astrophysics Data System (ADS)

    Coliolo, F.; Menendez, M.

    The widespread dissemination of science has always been one pillar of the development of human knowledge. There are several methods to structure interaction with the public: media, conferences, various written genres, and exhibitions. But: how to attract the public? How to arouse interest among future generation, insatiable for knowledge? In this paper we focus on space exhibitions, whose content combines mystery, discovery and science. The preparation of an exhibition is based on guidelines discussed between an interdisciplinary team and the exhibition project manager, the purpose of which is to find a coherent "strategy" to select information and to choose a concise, efficient, smart and original way to "visualize" the messages. Exhibition visitors are "privileged" because the interactivity is first emotive, then mental and cultural; the audience is universal. The goal of an exhibition is not to explain the content, but to stimulate the audience's curiosity in an attractive environment. We show some photos of ESA exhibitions, and try to understand if the visual impact is the first step towards a "multi-sensory" approach to communication. "A good exhibition can never be replaced by a book, a film or a lecture. A good exhibition creates a thirst for books, film, lectures. A good exhibition changes the visitors"(J. Wagensberg, Modern scientific museology")

  19. Regional asymmetry of metabolic and antioxidant profile in the sciaenid fish shi drum (Umbrina cirrosa) white muscle. Response to starvation and refeeding.

    PubMed

    Hidalgo, M Carmen; Morales, Amalia E; Arizcun, Marta; Abellán, Emilia; Cardenete, Gabriel

    2017-04-01

    The objective of the present study is to characterize the metabolic and antioxidant profile of white muscle of shi drum in two sites of the body, anterior dorsal (AM) and posterior dorsal (PM) portions. In addition, it will be analyzed the possible effect of starvation and a subsequent refeeding, with two different protocols, pair feeding and ad libitum. Activities of key enzymes of intermediary metabolism and of antioxidant enzymes, as well as lipid peroxidation, as an index of oxidative stress, were evaluated. The results indicate the existence of a regional asymmetry of the metabolic capacities of the white muscle of shi drum, which is likely related to the different contribution to swimming of the body regions examined. Starvation induces a metabolic depression that is more marked in those activities that support burst swimming in PM, while those activities supporting maintenance requirements are conserved. The greatest energy demands during starvation appear to lie in AM, which showed the highest oxidative metabolism rate. The increased use of fatty acids as energy source for AM leads to oxidative stress. A period of more than four weeks of refeeding for full restoration of metabolic capacities in AM is needed, probably related to the higher muscle mass located in this region. On the contrary, all enzyme activities in PM returned to control levels in both refeeding protocols, but pair feeding seems to be advantageous since compensatory growth has been taking place without signs of oxidative stress. This work was addressed to gain knowledge on the physiology of a promising fish species in aquaculture like shi drum. The results displayed here show how the starving and further re-feeding events could generate oxidative stress situations characterized by high lipid peroxidation levels which may influence negatively on the quality of the edible part of the fish. This study opens an interesting field on this fish species which deserves being investigated in the

  20. Sound production by the Shi drum Umbrina cirrosa and comparison with the brown meagre Sciaena umbra: a passive acoustic monitoring perspective.

    PubMed

    Picciulin, M; Bolgan, M; Corò, A B; Calcagno, G; Malavasi, S

    2016-04-01

    Sounds produced by the Shi drum Umbrina cirrosa were short trains of pulses with an average pulse period of 180 ms, pulse duration of c. 40 ms and an average peak frequency of 400 Hz; average values of acoustical properties differed from those recorded from the brown meagre Sciaena umbra in previous studies. The present study provides a preliminary tool for discriminating between these two species while conducting passive acoustic monitoring. The potential effects of ontogeny on sound production in both species are discussed and recommendations are made for further research.

  1. Superconductive microstrip exhibiting negative differential resistivity

    DOEpatents

    Huebener, R.P.; Gallus, D.E.

    1975-10-28

    A device capable of exhibiting negative differential electrical resistivity over a range of values of current and voltage is formed by vapor- depositing a thin layer of a material capable of exhibiting superconductivity on an insulating substrate, establishing electrical connections at opposite ends of the deposited strip, and cooling the alloy into its superconducting range. The device will exhibit negative differential resistivity when biased in the current- induced resistive state.

  2. Surface Conductive Graphene-Wrapped Micromotors Exhibiting Enhanced Motion.

    PubMed

    Ma, Xing; Katuri, Jaideep; Zeng, Yongfei; Zhao, Yanli; Sanchez, Samuel

    2015-10-01

    Surface-conductive Janus spherical motors are fabricated by wrapping silica particles with reduced graphene oxide capped with a thin Pt layer. These motors exhibit a 100% enhanced velocity as compared to standard SiO2 -Pt motors. Furthermore, the versatility of graphene may open up possibilities for a diverse range of applications from active drug delivery systems to water remediation.

  3. Encountering Nanotechnology in an Interactive Exhibition

    ERIC Educational Resources Information Center

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  4. Learning4Life on the Exhibit Floor

    ERIC Educational Resources Information Center

    Sullivan, Margaret

    2009-01-01

    The exhibit floor is a wealth of knowledge. One can read, view, and listen to information presented in many formats. Somewhere on the exhibit floor there are experts on every topic, ready and waiting for one's questions. But like any research topic, frequently a structured search is required to find the best answers. This article discusses how to…

  5. Evaluation of Clientele Impact of Science Exhibits.

    ERIC Educational Resources Information Center

    Talisayon, Vivien M.

    1998-01-01

    Explores the use of an impact evaluation model across time and clientele groups that is used to evaluate exhibits from two science centers in Manila. Questionnaire and interview data indicate that students prefer exhibits that produce sound, light, and motion. (DDR)

  6. 49 CFR 250.2 - Required exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... statement, together with supporting evidence, that the probable value of the assets of the railroad in the... carrier's existing railroad. (5) As Exhibit 5, statement showing miles of line owned; miles operated... carried; and identification of the ten most important industries served. (6) As Exhibit 6, statement as...

  7. Science Fiction Exhibits as STEM Gateways

    NASA Astrophysics Data System (ADS)

    Robie, Samantha

    Women continue to hold less than a quarter of all STEM jobs in the United States, prompting many museums to develop programs and exhibits with the express goal of interesting young girls in scientific fields. At the same time, a number of recent museum exhibits have harnessed the popularity of pop culture and science fiction in order to interest general audiences in STEM subject matter, as well as using the exhibits as springboards to expand or shift mission goals and focus. Because science fiction appears to be successful at raising interest in STEM fields, it may be an effective way to garner the interest of young girls in STEM in particular. This research seeks to describe the ways in which museums are currently using science fiction exhibits to interest young girls in STEM fields and careers. Research focused on four institutions across the country hosting three separate exhibits, and included staff interviews and content analysis of exhibit descriptions, promotional materials, a summative evaluation and supplementary exhibit productions. In some ways, science fiction exhibits do serve young girls, primarily through the inclusion of female role models, staff awareness, and prototype testing to ensure interactives are attractive to girls as well as to boys. However, STEM appears to be underutilized, which may be partly due to a concern within the field that the outcome of targeting a specific gender could be construed as "stereotyping".

  8. Strategies for Determining Exhibit Effectiveness. Final Report.

    ERIC Educational Resources Information Center

    Shettel, Harris H.; And Others

    This project was designed to develop research strategies and hypotheses for evaluating the effectiveness of exhibits. An exhibit on the role of the Federal Government in science and technology was used as the subject matter. Two basic groups of viewers were used, casual viewers and paid experimental viewers. Both were tested on knowledge gained…

  9. Neutron activation analysis of sources of raw material of Emperor Qin Shi Huang's Terracotta Warriors and Horses

    NASA Astrophysics Data System (ADS)

    Gao, Zhengyao; Zhao, Weijuan; Li, Guoxia; Xie, Jianzhong; Han, Guohe; Feng, Songlin; Fan, Dongyu; Zhang, Ying; Chai, Zhifang; Li, Rongwu; Zhang, Zhongli; Zhu, Junxiao

    2003-02-01

    There have been selected 83 samples of terracotta warriors and horses of Emperor Qin Shi Huang’s Mausoleum, 20 samples of clays taken from around Qin’s Mausoleum and 2 samples of Yaozhou porcelain bodies. All these samples have been measured by instrument neutron activation analysis (INAA) and as many as 32 kinds of element contents of each sample are measured. The following conclusion has been reached when fuzzy cluster analysis is conducted to element contents of all these samples: (i) The samples are roughly classified into five categories: namely, samples from pits No. 1 and No. 2; samples from pit No. 3; loam layers; the mixture of loam and loess; and Yaozhou porcelain bodies. (ii) The terracotta warriors and horses in pits No. 1, No. 2 and No. 3 are relatively independent from one another. The clays from which they were made are not entirely identical. We have found that samples in pit No. 3 are very closely related and their clay sources are comparatively concentrated. Samples in pits No. 1 and No. 2 are less related and their clay sources are comparatively scattered. (iii) The clays from which the terracotta warriors and horses were made are closely related to the loam layer near Qin’s Mausoleum, particularly to the loam layer of Zaoyuan village and Gaoxing village, but they are not so related to loess layers there, nor to the loam layers of Anhoubao, even less related to Yaozhou porcelain bodies. A rational deduction thus drawn is that the raw material of clays from which the terracotta warriors and horses were made might probably be taken from loam layers around Zaoyuan and Gaoxing, or loam layers near Qin’s Mausoleum whose properties are identical with those of loam layers of Zaoyuan and Gaoxing, rather than loess layers around the above places. Since the raw material of the terracotta warriors and horses was taken from loam near Qin’s Mausoleum, it could be deducted that the kiln sites might be located in around Qin’s Mausoleum.

  10. 7 CFR Exhibit G to Subpart E of... - Exhibit G to Subpart E of Part 1980

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Exhibit G to Subpart E of Part 1980 G Exhibit G to Subpart E of Part 1980 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING... Program Pt. 1980, Subpt. E, Exh. G Exhibit G to Subpart E of Part 1980 Note: The Exhibit is not...

  11. 43 CFR 4.824 - Exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Procedural Rules Applicable to Practice and Procedure for Hearings, Decisions, and Administrative Review... Interior-Effectuation of Title VI of the Civil Rights Act of 1964 Procedures § 4.824 Exhibits....

  12. 18 CFR 32.2 - Required exhibits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of operating such facilities. Exhibit B. A general or key map on a scale not greater than 20 miles to... facilities used for the generation and transmission of electric energy, indicating on said map the...

  13. The Making of a Museum Exhibition.

    ERIC Educational Resources Information Center

    Bleecker, Samuel E.

    1979-01-01

    Discusses the preparation of the Reptile and Amphibian exhibition at the American Museum of Natural History. Various steps involved in developing the ten showcases in a six-year period are presented. (SA)

  14. 18 CFR 153.8 - Required exhibits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) Exhibit D. If the proposal is for a pipeline interconnection to import or export natural gas, a copy of... authority, that will issue each required authorization; the date each request for authorization...

  15. Communicating Complex Sciences by Means of Exhibitions

    NASA Astrophysics Data System (ADS)

    Schneider, S.

    2011-12-01

    Earth Sciences will have to take over the leading role in global sustainable policy and in discussions about climate change. Efforts to raise attention within the politically responsible communities as well as in the public are getting more and more support by executive and advisory boards all over the world. But how can you successfully communicate complex sciences? For example, to start communication about climate change, the first step is to encourage people to be concerned about climate change. After that, one has to start thinking about how to present data and how to include the presented data into an unprejudiced context. Therefore, the communication toolbox offers various methods to reach diverse audiences. The R&D programme GEOTECHNOLOGIEN conducts roving exhibitions as one of its most successful communication tools. With roving exhibitions GEOTECHNOLOGIEN is able to get in touch with different audiences at once. The main purpose and theme of these exhibitions is to convey the everyday means of climate change to the visitors. It is within the responsibility of science to communicate the effects of a phenomenon like climate change as well as the impact of research results to the everyday life of people. Currently, a GEOTECHNOLOGIEN roving exhibition on remote sensing with satellites deals with various issues of environmental research, including a chapter on climate change. By following the 3M-concept (Meaning - Memorable - Moving), exhibitions allow to connect the visitors daily environment and personal experiences with the presented issues and objects. Therefore, hands-on exhibits, exciting multimedia effects and high-tech artefacts have to be combined with interpretive text elements to highlight the daily significance of the scientific topics and the exhibition theme respectively. To create such an exhibition, strong conceptual planning has to be conducted. This includes the specification of stern financial as well as time wise milestones. In addition

  16. When Do Children Exhibit a "Yes" Bias?

    ERIC Educational Resources Information Center

    Okanda, Mako; Itakura, Shoji

    2010-01-01

    This study investigated whether one hundred and thirty-five 3- to 6-year-old children exhibit a yes bias to various yes-no questions and whether their knowledge status affects the production of a yes bias. Three-year-olds exhibited a yes bias to all yes-no questions such as "preference-object" and "knowledge-object" questions pertaining to…

  17. Reaching the Public through Traveling Exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, P. B.; Harold, J. B.; Morrow, C. A.

    2004-11-01

    The Space Science Institute (SSI) of Boulder, Colorado has recently developed two museum exhibits called Alien Earths and MarsQuest. It has just started to develop another exhibit called Giant Planets. These exhibitions provide research scientists the opportunity to engage in a number of activities that are vital to the success of these major outreach programs. Alien Earths was developed in partnership with various research missions. The focus of the presentation will be on MarsQuest and Giant Planets. MarsQuest is a 5000 square-foot, \\$3M, traveling exhibition that is now touring the country. The exhibit's second 3-year tour will enable millions of Americans to share in the excitement of the scientific exploration of Mars and learn more about their own planet in the process. The associated planetarium show and education program will also be described, with particular emphasis on workshops to orient museum staff (e.g. museum educators and docents) and workshops for master educators near host museums and science centers. The workshops make innovative connections between the exhibition's interactive experiences and lesson plans aligned with the National Science Education Standards. These exhibit programs are good models for actively involving scientists and their discoveries to help improve informal science education in the museum community and for forging a stronger connection between formal and informal education. The presentation will also discuss how Giant Planets, a proposed 3500 square-foot traveling exhibition on the mysteries and discoveries of the outer planets, will be able to take advantage of the connections and resources that have been developed by the MarsQuest project.

  18. An Astrobiology Microbes Exhibit and Education Module

    NASA Technical Reports Server (NTRS)

    Lindstrom, Marilyn M.; Allen, Jaclyn S.; Stocco, Karen; Tobola, Kay; Olendzenski, Lorraine

    2001-01-01

    Telling the story of NASA-sponsored scientific research to the public in exhibits is best done by partnerships of scientists and museum professionals. Likewise, preparing classroom activities and training teachers to use them should be done by teams of teachers and scientists. Here we describe how we used such partnerships to develop a new astrobiology augmentation to the Microbes! traveling exhibit and a companion education module. "Additional information is contained in the original extended abstract."

  19. Sex differences in science museum exhibit attraction

    NASA Astrophysics Data System (ADS)

    Arámbula Greenfield, Teresa

    This study examines the relative attraction of hands-on, interactive science museum exhibits for females and males. Studies have demonstrated that such exhibits can be effective learning experiences for children, with both academic and affective benefits. Other studies have shown that girls and boys do not always experience the same science-related educational opportunities and that, even when they do, they do not necessarily receive the same benefits from them. These early differences can lead to more serious educational and professional disparities later in life. As interactive museum exhibits represent a science experience that is-readily available to both girls and boys, the question arose as to whether they were being used similarly by the two groups as well as by adult women and men. It was found that both girls and boys used all types of exhibits, but that girls were more likely than boys to use puzzles and exhibits focusing on the human body; boys were more likely than girls to use computers and exhibits illustrating physical science principles. However, this was less true of children accompanied by adults (parents) than it was of unaccompanied children on school field trips who roamed the museum more freely.Received: 16 February 1994; Revised: 3 February 1995;

  20. Using Comparative Planetology in Exhibit Development

    NASA Astrophysics Data System (ADS)

    Dusenbery, P. B.; Harold, J. B.; Morrow, C. A.

    2004-12-01

    It is critically important for the public to better understand the scientific process. Museum exhibitions are an important part of informal science education that can effectively reach public audiences as well as school groups. They provide an important gateway for the public to learn about compelling scientific endeavors. The Space Science Institute (SSI) is a national leader in producing traveling science exhibitions and their associated educational programming (i.e. interactive websites, educator workshops, public talks, instructional materials). The focus of this presentation will be on three of its exhibit projects: MarsQuest (currently on tour), Alien Earths (in fabrication), and Giant Planets (in development). MarsQuest is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and to learn more about their own planet in the process. Alien Earths will bring origins-related research and discoveries to students and the American public. It has four interrelated exhibit areas: Our Place in Space, Star Birth, PlanetQuest, and Search for Life. Exhibit visitors will explore the awesome events surrounding the birth of stars and planets; they will join scientists in the hunt for planets outside our solar system including those that may be in "habitable zones" around other stars; and finally they will be able to learn about how scientists are looking for signs of life beyond Earth. Giant Planets: Exploring the Outer Solar System will take advantage of the excitement generated by the Cassini mission and bring planetary and origins research and discoveries to students and the public. It will be organized around four thematic areas: Our Solar System; Colossal Worlds; Moons, Rings, and Fields; and Make Space for Kids. Giant Planets will open in 2007. This talk will focus on the importance of making Earth comparisons in the conceptual design of each exhibit and will show several examples of how these comparisons were manifested in

  1. Stereochemical aspects and the synthetic scope of the S(H)i at the sulfur atom. Preparation of enantiopure 3-substituted 2,3-dihydro-1,2-benzoisothiazole 1-oxides and 1,1-dioxides.

    PubMed

    Fernández-Salas, José A; Rodríguez-Fernández, M Mercedes; Maestro, M Carmen; García-Ruano, José L

    2014-06-07

    Intramolecular homolytic substitution (SHi) on the sulfur atom at acyclic N-(o-bromobenzyl)sulfinamides takes place with a complete inversion of the configuration and provides an excellent tool to connect N-tert-butanesulfinylimines with enantiopure 3-substituted benzo-fused sulfinamides (1,2-benzoisothiazoline 1-oxides) and the related pharmacologically relevant sulfonamides.

  2. Test of Shi et al. Method to Infer the Magnetic Reconnection Geometry from Spacecraft Data: MHD Simulation with Guide Field and Antiparallel Kinetic Simulation

    NASA Technical Reports Server (NTRS)

    Denton, R.; Sonnerup, B. U. O.; Swisdak, M.; Birn, J.; Drake, J. F.; Heese, M.

    2012-01-01

    When analyzing data from an array of spacecraft (such as Cluster or MMS) crossing a site of magnetic reconnection, it is desirable to be able to accurately determine the orientation of the reconnection site. If the reconnection is quasi-two dimensional, there are three key directions, the direction of maximum inhomogeneity (the direction across the reconnection site), the direction of the reconnecting component of the magnetic field, and the direction of rough invariance (the "out of plane" direction). Using simulated spacecraft observations of magnetic reconnection in the geomagnetic tail, we extend our previous tests of the direction-finding method developed by Shi et al. (2005) and the method to determine the structure velocity relative to the spacecraft Vstr. These methods require data from four proximate spacecraft. We add artificial noise and calibration errors to the simulation fields, and then use the perturbed gradient of the magnetic field B and perturbed time derivative dB/dt, as described by Denton et al. (2010). Three new simulations are examined: a weakly three-dimensional, i.e., quasi-two-dimensional, MHD simulation without a guide field, a quasi-two-dimensional MHD simulation with a guide field, and a two-dimensional full dynamics kinetic simulation with inherent noise so that the apparent minimum gradient was not exactly zero, even without added artificial errors. We also examined variations of the spacecraft trajectory for the kinetic simulation. The accuracy of the directions found varied depending on the simulation and spacecraft trajectory, but all the directions could be found within about 10 for all cases. Various aspects of the method were examined, including how to choose averaging intervals and the best intervals for determining the directions and velocity. For the kinetic simulation, we also investigated in detail how the errors in the inferred gradient directions from the unmodified Shi et al. method (using the unperturbed gradient

  3. Localized pulses exhibiting a missilelike slow decay.

    PubMed

    Shaarawi, Amr M; Maged, Maha A; Besieris, Ioannis M; Hashish, Essam

    2006-08-01

    We investigate the quasi-missile behavior of known localized wave solutions, such as the modified power spectrum and splash pulses. We demonstrate that source-free localized waves can exhibit slow decay rates analogous to Wu's missile solutions, which are characterized by an amplitude decay rate slower than 1/R over an unlimited range. When excited from a finite aperture, the missilelike decay is not exhibited by all localized waves showing such behavior in the source-free situation. On the other hand, localized wave missiles generated from a finite aperture have peaks that exhibit quasi-missile decay. In an extended intermediate range between the near- and the far-field regions, these pulses decay at a rate slower than 1/R before switching to the usual 1/R decay.

  4. Localized pulses exhibiting a missilelike slow decay

    NASA Astrophysics Data System (ADS)

    Shaarawi, Amr M.; Maged, Maha A.; Besieris, Ioannis M.; Hashish, Essam

    2006-08-01

    We investigate the quasi-missile behavior of known localized wave solutions, such as the modified power spectrum and splash pulses. We demonstrate that source-free localized waves can exhibit slow decay rates analogous to Wu's missile solutions, which are characterized by an amplitude decay rate slower than 1/R over an unlimited range. When excited from a finite aperture, the missilelike decay is not exhibited by all localized waves showing such behavior in the source-free situation. On the other hand, localized wave missiles generated from a finite aperture have peaks that exhibit quasi-missile decay. In an extended intermediate range between the near- and the far-field regions, these pulses decay at a rate slower than 1/R before switching to the usual 1/R decay.

  5. The Gravity- Powered Calculator, a Galilean Exhibit

    NASA Astrophysics Data System (ADS)

    Cerreta, Pietro

    2014-04-01

    The Gravity-Powered Calculator is an exhibit of the Exploratorium in San Francisco. It is presented by its American creators as an amazing device that extracts the square roots of numbers, using only the force of gravity. But if you analyze his concept construction one can not help but recall the research of Galileo on falling bodies, the inclined plane and the projectile motion; exactly what the American creators did not put into prominence with their exhibit. Considering the equipment only for what it does, in my opinion, is very reductive compared to the historical roots of the Galilean mathematical physics contained therein. Moreover, if accurate deductions are contained in the famous study of S. Drake on the Galilean drawings and, in particular on Folio 167 v, the parabolic paths of the ball leaping from its launch pad after descending a slope really actualize Galileo's experiments. The exhibit therefore may be best known as a `Galilean calculator'.

  6. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.

    PubMed

    Obradović, Aleksandar Lj; Joksimović, Srđan; Poe, Michael M; Ramerstorfer, Joachim; Varagic, Zdravko; Namjoshi, Ojas; Batinić, Bojan; Radulović, Tamara; Marković, Bojan; Roth, Brian L; Sieghart, Werner; Cook, James M; Savić, Miroslav M

    2014-03-20

    Enormous progress in understanding the role of four populations of benzodiazepine-sensitive GABAA receptors was paralleled by the puzzling findings suggesting that substantial separation of behavioral effects may be accomplished by apparently non-selective modulators. We report on SH-I-048A, a newly synthesized chiral positive modulator of GABAA receptors characterized by exceptional subnanomolar affinity, high efficacy and non-selectivity. Its influence on behavior was assessed in Wistar rats and contrasted to that obtained with 2mg/kg diazepam. SH-I-048A reached micromolar concentrations in brain tissue, while the unbound fraction in brain homogenate was around 1.5%. The approximated electrophysiological responses, which estimated free concentrations of SH-I-048A or diazepam are able to elicit, suggested a similarity between the 10mg/kg dose of the novel ligand and 2mg/kg diazepam; however, SH-I-048A was relatively more active at α1- and α5-containing GABAA receptors. Behaviorally, SH-I-048A induced sedative, muscle relaxant and ataxic effects, reversed mechanical hyperalgesia 24h after injury, while it was devoid of clear anxiolytic actions and did not affect water-maze performance. While lack of clear anxiolytic actions may be connected with an enhanced potentiation at α1-containing GABAA receptors, the observed behavior in the rotarod, water maze and peripheral nerve injury tests was possibly affected by its prominent action at receptors containing the α5 subunit. The current results encourage further innovative approaches aimed at linking in vitro and in vivo data in order to help define fine-tuning mechanisms at four sensitive receptor populations that underlie subtle differences in behavioral profiles of benzodiazepine site ligands.

  7. 18 CFR 32.2 - Required exhibits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... facilities used for the generation and transmission of electric energy, indicating on said map the points... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Required exhibits. 32.2 Section 32.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT...

  8. 18 CFR 32.2 - Required exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... facilities used for the generation and transmission of electric energy, indicating on said map the points... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Required exhibits. 32.2 Section 32.2 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT...

  9. 18 CFR 34.4 - Required exhibits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Required exhibits. 34.4 Section 34.4 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT APPLICATION FOR AUTHORIZATION OF THE ISSUANCE...

  10. FluxBase: An Interactive Art Exhibition.

    ERIC Educational Resources Information Center

    Huntley, Joan S.; Partridge, Michael

    1992-01-01

    Describes a computer program that gives Fluxus exhibition attendees an opportunity to experience the Flux objects in the spirit in which they were originally created. Suggests that the computer program provides a virtual approximation to the original art works without damaging them. (RS)

  11. 32 CFR 705.24 - Exhibits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... be displayed in any appropriate location or event (including commercially owned spaces such as... for Navy exhibits in events of international or national scope, or those requiring major coordination... will be used. See Armed Forces Request Form, § 705.36. (4) Requests for exceptions to policy...

  12. 32 CFR 705.24 - Exhibits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... be displayed in any appropriate location or event (including commercially owned spaces such as... for Navy exhibits in events of international or national scope, or those requiring major coordination... will be used. See Armed Forces Request Form, § 705.36. (4) Requests for exceptions to policy...

  13. 32 CFR 705.24 - Exhibits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... be displayed in any appropriate location or event (including commercially owned spaces such as... for Navy exhibits in events of international or national scope, or those requiring major coordination... will be used. See Armed Forces Request Form, § 705.36. (4) Requests for exceptions to policy...

  14. 32 CFR 705.24 - Exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... be displayed in any appropriate location or event (including commercially owned spaces such as... for Navy exhibits in events of international or national scope, or those requiring major coordination... will be used. See Armed Forces Request Form, § 705.36. (4) Requests for exceptions to policy...

  15. Do Online Students Exhibit Different Learning Styles

    ERIC Educational Resources Information Center

    Hausler, Joel; Sanders, John W.; Young, Barbara

    2007-01-01

    We examined the relationship between learning styles and student type. This research seeks to examine if online students exhibit different learning styles from onsite students; and, if so, what accommodations relating to learning style differences may be made for online students? Students (N = 80) were asked to complete an online survey in order…

  16. The medial prefrontal cortex exhibits money illusion

    PubMed Central

    Weber, Bernd; Rangel, Antonio; Wibral, Matthias; Falk, Armin

    2009-01-01

    Behavioral economists have proposed that money illusion, which is a deviation from rationality in which individuals engage in nominal evaluation, can explain a wide range of important economic and social phenomena. This proposition stands in sharp contrast to the standard economic assumption of rationality that requires individuals to judge the value of money only on the basis of the bundle of goods that it can buy—its real value—and not on the basis of the actual amount of currency—its nominal value. We used fMRI to investigate whether the brain's reward circuitry exhibits money illusion. Subjects received prizes in 2 different experimental conditions that were identical in real economic terms, but differed in nominal terms. Thus, in the absence of money illusion there should be no differences in activation in reward-related brain areas. In contrast, we found that areas of the ventromedial prefrontal cortex (vmPFC), which have been previously associated with the processing of anticipatory and experienced rewards, and the valuation of goods, exhibited money illusion. We also found that the amount of money illusion exhibited by the vmPFC was correlated with the amount of money illusion exhibited in the evaluation of economic transactions. PMID:19307555

  17. Comic Strips to Accompany Science Museum Exhibits

    ERIC Educational Resources Information Center

    Chung, Beom Sun; Park, Eun-mi; Kim, Sang-Hee; Cho, Sook-kyoung; Chung, Min Suk

    2016-01-01

    Science museums make the effort to create exhibits with amusing explanations. However, existing explanation signs with lengthy text are not appealing, and as such, visitors do not pay attention to them. In contrast, conspicuous comic strips composed of simple drawings and humors can attract science museum visitors. This study attempted to reveal…

  18. After Terror Charges, Artist Exhibits Academic Freedom

    ERIC Educational Resources Information Center

    Wilson, Robin

    2008-01-01

    Steven Kurtz, a professor of visual studies at the State University of New York, has been working with various bacteria as part of his counterculture exhibit artworks for nearly 20 years. Four years ago, federal agents raided his home in a bioterrorism investigation. The federal agents had been called to the house by local police officers…

  19. 18 CFR 156.5 - Exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... such enterprises or operations, a detailed explanation of each such relationship, including the... relationship. (5) Exhibit F—Location of facilities. A geographical map of suitable scale and detail showing all... proposed customers; derivation of numbers of customers proposed to be served; individual consumer peak...

  20. 18 CFR 157.14 - Exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... explanation of each such relationship, including the percentage of voting strength represented by such... detailed explanation of each such relationship. (5) Exhibit E—Other pending applications and filings. A... abandoned. This map, or an additional map, shall clearly show the relationship of the new facilities to...

  1. 18 CFR 153.8 - Required exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... LNG, evidence that an appropriate and qualified concern will properly and safely receive or deliver such LNG, including a report containing detailed engineering and design information. The Commission... Office of Energy Projects, 888 First Street, NE., Washington, DC 20426; (6) Exhibit E-1. If the...

  2. 18 CFR 50.7 - Applications: exhibits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Applications: exhibits. 50.7 Section 50.7 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT APPLICATIONS FOR PERMITS TO SITE...

  3. 18 CFR 50.7 - Applications: exhibits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Applications: exhibits. 50.7 Section 50.7 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT APPLICATIONS FOR PERMITS TO SITE...

  4. 18 CFR 153.8 - Required exhibits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... LNG, evidence that an appropriate and qualified concern will properly and safely receive or deliver such LNG, including a report containing detailed engineering and design information. The Commission... Office of Energy Projects, 888 First Street, NE., Washington, DC 20426; (6) Exhibit E-1. If the...

  5. 18 CFR 156.5 - Exhibits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... separate volume or volumes shall indicate on the cover thereof applicant's name and bear Docket No. CP... an equivalent Btu basis. (12) Exhibit K—Cost of facilities. A detailed estimate of total capital cost.... (vii) A balance sheet and income statement (12 months) of most recent date available....

  6. 18 CFR 156.5 - Exhibits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... separate volume or volumes shall indicate on the cover thereof applicant's name and bear Docket No. CP... an equivalent Btu basis. (12) Exhibit K—Cost of facilities. A detailed estimate of total capital cost.... (vii) A balance sheet and income statement (12 months) of most recent date available....

  7. Measurement of parameters of scintillating bars with wavelength-shifting fibres and silicon photomultiplier readout for the SHiP Muon Detector

    NASA Astrophysics Data System (ADS)

    Baldini, W.; Blondel, A.; Calcaterra, A.; Jacobsson, R.; Khotjantsev, A.; Kudenko, Y.; Kurochka, V.; Lanfranchi, G.; Mefodiev, A.; Mineev, O.; Montanari, A.; Noah Messomo, E.; Saputi, A.; Tosi, N.

    2017-03-01

    The light yield and the time resolution of different types of 3 m long scintillating bars instrumented with wavelength shifting fibres and read out by different models of silicon photomultipliers have been measured at a test beam at the T9 area at the CERN Proton Synchrotron. The results obtained with different configurations are presented. A time resolution better than 800 ps, constant along the bar length within 20%, and a light yield of 0~ 14 (70) photoelectrons are obtained for bars 3 m long, ~ 4.5 (5) cm wide and 2 (0.7) cm thick. These results nicely match the requirements for the Muon Detector of the SHiP experiment.

  8. Surface expression of toll-like receptor 4 on THP-1 cells is modulated by Bu-Zhong-Yi-Qi-Tang and Shi-Quan-Da-Bu-Tang.

    PubMed

    Mita, Y; Dobashi, K; Shimizu, Y; Nakazawa, T; Mori, M

    2002-03-01

    Human Toll-like receptor 4 (TLR4) has recently been identified and has been shown to be the main protein involved in recognizing Gram-negative bacteria. We examined the regulation of TLR4 surface expression in a human monocytic cell line (THP-1 cells) by two traditional Chinese herbal medicines. Bu-Zhong-Yi-Qi-Tang (TJ-41) and Shi-Quan-Da-Bu-Tang (TJ-48). TJ-41 and TJ-48 upregulated TLR4 surface expression in THP-1 cells, as well as enhanced TLR4 surface expression in these cells both dose- and time-dependently. These findings suggest that TJ-41 and TJ-48 increase the receptor involved in the response to Gram-negative bacteria and may enhance defenses against these pathogens.

  9. Light dark matter in neutrino beams: Production modeling and scattering signatures at MiniBooNE, T2K, and SHiP

    NASA Astrophysics Data System (ADS)

    deNiverville, Patrick; Chen, Chien-Yi; Pospelov, Maxim; Ritz, Adam

    2017-02-01

    We analyze the prospects for detection of light sub-GeV dark matter produced in experiments designed to study the properties of neutrinos, such as MiniBooNE, T2K, SHiP, DUNE etc. We present an improved production model, when dark matter couples to hadronic states via a dark photon or baryonic vector mediator, incorporating bremsstrahlung of the dark vector. In addition to elastic scattering, we also study signatures of light dark matter undergoing deep inelastic or quasielastic NC π0 -like scattering in the detector producing neutral pions, which for certain experiments may provide the best sensitivity. Supplemental Material provides extensive documentation for a publicly available simulation tool BdNMC that can be applied to determine the hidden sector dark matter production and scattering rate at a range of proton fixed target experiments.

  10. The palaeontological exhibition: a venue for dialogue.

    PubMed

    Murriello, Sandra

    2015-01-01

    Understanding the dialogue between museums and their visitors enables museums to subsist, undergo transformations and become consolidated as socially valued cultural venues. The Museo de La Plata (Argentina) was created in the late nineteenth century as a natural history museum, and this study shows that currently the museum is valued socially as a venue for family leisure and education, at which people make sense to the objects exhibited through characteristics conferred upon them by both the institution and the visitor. Nevertheless, such dialogue is somehow affected by the museographic proposal and the public interpretation of the institutional narrative, which could be analysed within the frame of contextual learning. As a consequence, the evolutionary idea that the museum aims to communicate is distorted by the public. This article highlights the importance of considering the visitors' interpretations when planning museum exhibitions, a perspective that has been rather absent in the Argentinian museums.

  11. Barium hexaferrite (M-phase) exhibiting superstructure

    SciTech Connect

    Ganapathi, L.; Gopalakrishnan, J.; Rao, C.N.R.

    1984-05-01

    Barium hexaferrite (M-phase) prepared by the flux method is found to exhibit a ..sqrt..3a x ..sqrt..3a superstructure similar to barium hexaaluminate. Morgan and Shaw as well as Iyi et al have recently reported the formation of a barium-rich phase of barium hexaaluminate possessing a ..sqrt..3a x ..sqrt..3a superstructure of the magnetoplumbite structure. In view of the similarities between the layer structures of ..beta..-aluminas and the corresponding ferrites the authors have been carrying out electron microscopic investigations of potassium ..beta..-alumina and BaA1/sub 12/O/sub 19/ along with ferrites of similar compositions. They have obtained electron diffraction patterns of barium hexaaluminate identical to those obtained by Morgan and Shaw and Iyi et al, but more interestingly, they have found a phase of barium hexaferrite (M-phase) exhibiting the ..sqrt..3a x ..sqrt..3a superstructure.

  12. Naval Meteorology and Oceanography Command exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Designed to entertain while educating, StenniSphere at the John C. Stennis Space Center in Hancock County, Miss., includes informative displays and exhibits from NASA and other agencies located at Stennis, such as this one from the Naval Meteorology and Oceanography Command. Visitors can 'travel' three-dimensionally under the sea and check on the weather back home in the Weather Center. StenniSphere is open free of charge from 9 a.m. to 5 p.m. daily.

  13. Naval Meteorology and Oceanography Command exhibit entrance

    NASA Technical Reports Server (NTRS)

    2000-01-01

    StenniSphere at NASA's John C. Stennis Space Center in Hancock County, Miss., invites visitors to discover why America comes to Stennis Space Center before going into space. Designed to entertain while educating, StenniSphere includes informative displays and exhibits from NASA and other agencies located at Stennis, such as this one from the Naval Meteorology and Oceanography Command. Visitors can 'travel' three-dimensionally under the sea and check on the weather back home in the Weather Center.

  14. Art exhibit focuses on African astronomy

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-07-01

    Connections between Africans and astronomy are the focus of a new exhibition in the National Museum of African Art in Washington, D. C. "African Cosmos: Stellar Arts," which includes artwork, cultural items, and scientific displays from ancient to contemporary times, is the first major exhibit "that brings together arts and science focused on Africa's contribution to keen observations of the heavens over time," curator Christine Mullen Kreamer said at a 20 June news briefing. Among the exhibit's nearly 100 objects are an ancient Egyptian mummy board that includes a representation of the sky goddess Nut, sculptures by the Dogon people of Mali depicting figures in relation to the cosmos, a video that uses data from two square degrees of the Hubble Space Telescope Cosmic Evolution Survey, and a nearly floor-to-ceiling "Rainbow Serpent" constructed of plastic containers by Benin artist Hazoume. An untitled acrylic painting (Figure 1) by South African Gavin Jantjes evokes a myth of the Khoi San people of southern Africa, as it portrays a girl throwing evening fire embers into the night sky, where they remained as the Milky Way.

  15. When do children exhibit a "yes" bias?

    PubMed

    Okanda, Mako; Itakura, Shoji

    2010-01-01

    This study investigated whether one hundred and thirty-five 3- to 6-year-old children exhibit a yes bias to various yes-no questions and whether their knowledge status affects the production of a yes bias. Three-year-olds exhibited a yes bias to all yes-no questions such as preference-object and knowledge-object questions pertaining to objects, and knowledge-face questions pertaining to facial expressions. Four-year-olds tended to say "yes" only to knowledge-object questions. Five-year-olds did not show any strong response tendency. Six-year-olds exhibited a nay-saying bias to knowledge-face questions. Also, 3-year-olds could indicate the correct option when asked questions with 2 response options. It suggested that 3-year-olds tended to inappropriately say "yes" to yes-no questions, although they knew the answers to the questions. The mechanism of a yes bias was discussed.

  16. The E = mc{sup 2} exhibition

    SciTech Connect

    Henderson, D.; Peshkin, M.

    1995-08-01

    The goal of this DOE-supported exhibition is to demystify Einstein`s formula E = mc{sup 2} by illustrating the interchangeability of matter (m) and energy (E), c{sup 2} being the exchange rate. The exhibition has two major parts, {open_quotes}matter into energy{close_quotes} and {open_quotes}energy into matter{close_quotes}, plus a video to connect them. {open_quotes}Matter into energy{close_quotes} has now been completed and has been placed on the museum floor. Positrons from a {sup 22}Na source are annihilated to produce gamma rays that are caught in NaI detectors. The viewer can alter the alignment of the detectors and observe the consequences for the rates of single and coincident counts. The viewer can also observe the effects of placing absorbers in front of the counters. Prototype explanatory graphics were placed around the exhibit and those will probably be changed after we have some experience with their effectiveness. The connecting video is in the process of being produced in collaboration with Fermilab. A cloud chamber for {open_quotes}energy into matter{close_quotes}, where gamma rays from a small Th source will produce observable pairs, was purchased and work to make the pairs visible has commenced.

  17. 7 CFR Exhibit G to Subpart E of... - Exhibit G to Subpart E of Part 1980

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Exhibit G to Subpart E of Part 1980 G Exhibit G to Subpart E of Part 1980 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY,...

  18. Mars in their eyes - a cartoon exhibition

    NASA Astrophysics Data System (ADS)

    Pillinger, Pi.

    Recently a collection of 120 cartoons which tell the story of Mars exploration and scientific discovery, past, present and future, was held in London. We discuss the aims of the exhibition, to what extent we believe the original aims were met and report on additional outreach opportunities resulting from the project. The overriding aim was to capitalise on the popular appeal of accessible art - most people admit to enjoying cartoons. This was strengthened by hanging the originals of cartoons which had, mostly, been published in newspapers and magazines in a wide selection of countries. The provenances served to indicate the attraction of Mars to a wide public. We were fortunate to work with the Cartoon Art Trust of the UK who was in the process of relocating to new premises and opening as The Cartoon Museum, in the tourist area of Bloomsbury, central London, very close to the British Museum. "Mars in their Eyes" ran for 10 weeks during April to July 2006; immediately following which a selection of the cartoons was displayed at the week-long Royal Society Summer Exhibition. We explore the differences between the two exhibitions and comment on the various audience responses. We use this comparison to discuss whether a project which is primarily art can be extended to explain science. Does the coupling merely result in dumbing-down of both cultures or is there a true synergy? The experience has led us to coin the phrase "extreme outreach". Projects which are as ambitious as "Mars in their Eyes", without the security of a safe, captive audience, for example at a Science Centre, must be judged by different criteria. Indeed if the project does not meet comparable targets like large visitor numbers, then the honest evaluation of such details can only inform future activities and must not be reflected in the future funding of only "safe" outreach activities.

  19. Non-swarming grasshoppers exhibit density-dependent phenotypic plasticity reminiscent of swarming locusts.

    PubMed

    Gotham, Steven; Song, Hojun

    2013-11-01

    Locusts are well known for exhibiting an extreme form of density-dependent phenotypic plasticity known as locust phase polyphenism. At low density, locust nymphs are cryptically colored and shy, but at high density they transform into conspicuously colored and gregarious individuals. Most of what we know about locust phase polyphenism come from the study of the desert locust Schistocerca gregaria (Forskål), which is a devastating pest species affecting many countries in North Africa and the Middle East. The desert locust belongs to the grasshopper genus Schistocerca Stål, which includes mostly non-swarming, sedentary species. Recent phylogenetic studies suggest that the desert locust is the earliest branching lineage within Schistocerca, which raises a possibility that the presence of density-dependent phenotypic plasticity may be a plesiomorphic trait for the whole genus. In order to test this idea, we have quantified the effect of rearing density in terms of the resulting behavior, color, and morphology in two non-swarming Schistocerca species native to Florida. When reared in both isolated and crowded conditions, the two non-swarming species, Schistocerca americana (Drury) and Schistocerca serialis cubense (Saussure) clearly exhibited plastic reaction norms in all traits measured, which were reminiscent of the desert locust. Specifically, we found that both species were more active and more attracted to each other when reared in a crowded condition than in isolation. They were mainly bright green in color when isolated, but developed strong black patterns and conspicuous background colors when crowded. We found a strong effect of rearing density in terms of size. There were also more mechanoreceptor hairs on the outer face of the hind femora in the crowded nymphs in both species. Although both species responded similarly, there were some clear species-specific differences in terms of color and behavior. Furthermore, we compare and contrast our findings with

  20. Art Therapy Exhibitions: Exploitation or Advocacy?

    PubMed

    Davis, Terri

    2017-01-01

    Promoting awareness of human trafficking by sharing trauma survivors' art and summaries of their life stories suggests ethical complexities that have been typically neglected by bioethicists. Although these survivors voluntarily share the objects they created during art therapy sessions, they are still at risk of harm, including further exploitation, due to their vulnerability, high rates of victim sensitivity, and the mental health consequences of their traumatic experiences. While some argue that the benefits of sublimation and art therapy for human trafficking survivors make sharing their art worth the risk, anti-trafficking organizations and supporters of such art exhibitions have responsibilities to be trauma informed.

  1. A metafluid exhibiting strong optical magnetism.

    PubMed

    Sheikholeslami, Sassan N; Alaeian, Hadiseh; Koh, Ai Leen; Dionne, Jennifer A

    2013-09-11

    Advances in the field of metamaterials have enabled unprecedented control of light-matter interactions. Metamaterial constituents support high-frequency electric and magnetic dipoles, which can be used as building blocks for new materials capable of negative refraction, electromagnetic cloaking, strong visible-frequency circular dichroism, and enhancing magnetic or chiral transitions in ions and molecules. While all metamaterials to date have existed in the solid-state, considerable interest has emerged in designing a colloidal metamaterial or "metafluid". Such metafluids would combine the advantages of solution-based processing with facile integration into conventional optical components. Here we demonstrate the colloidal synthesis of an isotropic metafluid that exhibits a strong magnetic response at visible frequencies. Protein-antibody interactions are used to direct the solution-phase self-assembly of discrete metamolecules comprised of silver nanoparticles tightly packed around a single dielectric core. The electric and magnetic response of individual metamolecules and the bulk metamaterial solution are directly probed with optical scattering and spectroscopy. Effective medium calculations indicate that the bulk metamaterial exhibits a negative effective permeability and a negative refractive index at modest fill factors. This metafluid can be synthesized in large-quantity and high-quality and may accelerate development of advanced nanophotonic and metamaterial devices.

  2. 17 CFR 229.601 - (Item 601) Exhibits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... by reference, the exhibits required in the exhibit table shall be filed as indicated, as part of the... exhibit table. The exhibit index shall indicate, by handwritten, typed, printed, or other legible form of... index is located. For a description of each of the exhibits included in the exhibit table, see...

  3. Supercomputing meets seismology in earthquake exhibit

    ScienceCinema

    Blackwell, Matt; Rodger, Arthur; Kennedy, Tom

    2016-07-12

    When the California Academy of Sciences created the "Earthquake: Evidence of a Restless Planet" exhibit, they called on Lawrence Livermore to help combine seismic research with the latest data-driven visualization techniques. The outcome is a series of striking visualizations of earthquakes, tsunamis and tectonic plate evolution. Seismic-wave research is a core competency at Livermore. While most often associated with earthquakes, the research has many other applications of national interest, such as nuclear explosion monitoring, explosion forensics, energy exploration, and seismic acoustics. For the Academy effort, Livermore researchers simulated the San Andreas and Hayward fault events at high resolutions. Such calculations require significant computational resources. To simulate the 1906 earthquake, for instance, visualizing 125 seconds of ground motion required over 1 billion grid points, 10,000 time steps, and 7.5 hours of processor time on 2,048 cores of Livermore's Sierra machine.

  4. Supercomputing meets seismology in earthquake exhibit

    SciTech Connect

    Blackwell, Matt; Rodger, Arthur; Kennedy, Tom

    2013-10-03

    When the California Academy of Sciences created the "Earthquake: Evidence of a Restless Planet" exhibit, they called on Lawrence Livermore to help combine seismic research with the latest data-driven visualization techniques. The outcome is a series of striking visualizations of earthquakes, tsunamis and tectonic plate evolution. Seismic-wave research is a core competency at Livermore. While most often associated with earthquakes, the research has many other applications of national interest, such as nuclear explosion monitoring, explosion forensics, energy exploration, and seismic acoustics. For the Academy effort, Livermore researchers simulated the San Andreas and Hayward fault events at high resolutions. Such calculations require significant computational resources. To simulate the 1906 earthquake, for instance, visualizing 125 seconds of ground motion required over 1 billion grid points, 10,000 time steps, and 7.5 hours of processor time on 2,048 cores of Livermore's Sierra machine.

  5. Virtual auditorium concepts for exhibition halls

    NASA Astrophysics Data System (ADS)

    Evans, Jack; Himmel, Chad; Knight, Sarah

    2002-11-01

    Many communities lack good performance facilities for symphonic music, opera, dramatic and musical arts, but have basic convention, exhibition or assembly spaces. It should be possible to develop performance space environments within large multipurpose facilities that will accommodate production and presentation of dramatic arts. Concepts for moderate-cost, temporary enhancements that transform boxy spaces into more intimate, acoustically articulated venues will be presented. Acoustical criteria and design parameters will be discussed in the context of creating a virtual auditorium within the building envelope. Physical, economic, and logistical limitations affect implementation. Sound reinforcement system augmentation can supplement the room conversion. Acceptable control of reflection patterns, reverberation, and to some extent, ambient noise, may be achieved with an array of nonpermanent reflector and absorber elements. These elements can sculpture an enclosure to approach the shape and acoustic characteristics of an auditorium. Plan and section illustrations will be included.

  6. A Traveling Exhibit of Cassini Image Science

    NASA Astrophysics Data System (ADS)

    Burns, Joseph A.; Hedman, M. M.; Tiscareno, M. S.; Ebel, D.; Mac Low, M.; Lovett, L. E.; Burns, J. K.; Schaff, N.; Bilson, E. M.

    2007-10-01

    An exhibit of Cassini's images will open at NYC's American Museum of Natural History in March 2008 and then visit the Johnson Art Museum (Cornell) throughout fall 2008, including during next year's DPS. It is under consideration by several other venues in the States and overseas. The exhibit will feature 40-50 images, ranging from letter size to large posters, taken by remote-sensing instruments aboard Cassini and Huygens. Photos will be organized into a half-dozen thematic clusters (e.g., organized by celestial target or by physical process); a panel will introduce each grouping with individual images identified briefly. The Saturn system is a perfect vehicle to educate citizens about planetary science and origins. The images’ beauty should capture the public's attention, allowing us to then engage their curiosity about the relevant science. Among the Saturn system's broad suite of objects are Enceladus and Titan, two satellites of astrobiological interest; moreover, the rings display many processes active in other astrophysical disks. Several auxiliary ideas will be implemented. In Ithaca, we will project images at night against the museum's sand-colored exterior walls. A 10-12 minute musical composition has been commissioned from Roberto Sierra to open the show. We will encourage school children to participate in a human orrery circling the museum and will seek volunteers to participate in several Saturnalia. At Cornell we will involve the university and local communities, by taping their reactions to the images’ exquisite beauty as well as to their scientific content. Cassini will be the E/PO focus of next year's DPS meeting; those materials will be employed throughout the fall at New York schools and be available to travel with the show. We intend to work with NYC partners to offer teacher credits for associated weekend courses. We will produce classroom materials, including a DVD, for teacher use.

  7. Application of an imaging system to a museum exhibition for developing interactive exhibitions

    NASA Astrophysics Data System (ADS)

    Miyata, Kimiyoshi; Inoue, Yuka; Takiguchi, Takahiro; Tsumura, Norimichi; Nakaguchi, Toshiya; Miyake, Yoichi

    2009-10-01

    In the National Museum of Japanese History, 215,759 artifacts are stored and used for research and exhibitions. In museums, due to the limitation of space in the galleries, a guidance system is required to satisfy visitors' needs and to enhance their understanding of the artifacts. We introduce one exhibition using imaging technology to improve visitors' understanding of a kimono (traditional Japanese clothing) exhibition. In the imaging technology introduced, one data projector, one display with touch panel interface, and magnifiers were used as exhibition tools together with a real kimono. The validity of this exhibition method was confirmed by results from a visitors' interview survey. Second, to further develop the interactive guidance system, an augmented reality system that consisted of cooperation between the projector and a digital video camera was also examined. A white paper board in the observer's hand was used as a projection screen and also as an interface to control the images projected on the board. The basic performance of the proposed system was confirmed; however continuous development was necessary for applying the system to actual exhibitions.

  8. Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of Sjögren’s Syndrome-Like NOD/ShiLtJ Mice - A Pilot Study

    PubMed Central

    Easley, Justin T; Nelson, Joel W; Mellas, Rachel E; Sommakia, Salah; Wu, Chunhua; Trump, Bryan; Baker, Olga J

    2016-01-01

    Resolvin D1 (RvD1) and its aspirin-triggered epimeric form (AT-RvD1) are endogenous lipid mediators (derived from docosahexaenoic acid, DHA) that control the duration and magnitude of inflammation in models of complex diseases. Our previous studies demonstrated that RvD1-mediated signaling pathways are expressed and active in salivary glands from rodents and humans. Furthermore, treatment of salivary cells with RvD1 blocked TNF-α-mediated inflammatory signals and improved epithelial integrity. The purpose of this pilot study was to determine the feasibility of treatment with AT-RvD1 versus dexamethasone (DEX) on inflammation (i.e., lymphocytic infiltration, cytokine expression and apoptosis) observed in submandibular glands (SMG) from the NOD/ShiLtJ Sjögren’s syndrome (SS) mouse model before experimenting with a larger population. NOD/ShiLtJ mice were treated intravenously with NaCl (0.9%, negative control), AT-RvD1 (0.01–0.1 mg/kg) or DEX (4.125–8.25 mg/kg) twice a week for 14 weeks beginning at 4 weeks of age. At 18 weeks of age, SMG were collected for pathological analysis and detection of SS-associated inflammatory genes. The AT-RvD1 treatment alone did not affect lymphocytic infiltration seen in NOD/ShiLtJ mice while DEX partially prevented lymphocytic infiltration. Interestingly, both AT-RvD1 and DEX caused downregulation of SS-associated inflammatory genes and reduction of apoptosis. Results from this pilot study suggest that a systemic treatment with AT-RvD1 and DEX alone attenuated inflammatory responses observed in the NOD/ShiLtJ mice; therefore, they may be considered as potential therapeutic tools in treating SS patients when used alone or in combination. PMID:27110599

  9. Naïve prey exhibit reduced antipredator behavior and survivorship

    PubMed Central

    2014-01-01

    Prey naiveté has been hypothesized to be one of the major driving forces behind population declines following the introduction of novel predators or release of inexperienced prey into predator rich environments. In these cases, naïve prey may lack sufficient antipredator behavior and, as a result, suffer increased mortality. Despite this, some evidence suggests that many prey utilize a generalized response to predators. Here, the naiveté hypothesis is tested using a predator–prey pair sharing an evolutionary history: the red swamp crayfish (Procambarus clarkii Girard, 1852) and largemouth bass (Micropterus salmoides Lacépède, 1802). Using farm-reared, naïve crayfish and wild-caught, experienced individuals, laboratory experiments demonstrated that naïve, farmed crayfish lack behavioral responses to chemical cues from bass, both in terms of movement and use of structural refuge. In contrast, experienced crayfish responded strongly to the same cues. In a subsequent field tethering experiment, these naïve individuals suffered a three-fold increase in predation rate. Based on these results, recognition of predators may not be innate in all prey, and previous experience and learning likely play a key role in the development of antipredator behavior. PMID:25392763

  10. Green Synthesized Silver Nanoparticles Exhibit Reduced Toxicity to Mammalian Cells and Retain Antimicrobial Activity

    EPA Science Inventory

    The interest in silver nanoparticles (AgNPs) and silver nanomaterial stems from their antimicrobial properties. AgNPs are being added to clothing, paint, refrigerators, washing machines and a variety of other commercially available items. Recent in vitro and in vivo studies, howe...

  11. A two-step route to planar perovskite cells exhibiting reduced hysteresis

    SciTech Connect

    Ip, Alexander H.; Adachi, Michael M.; McDowell, Jeffrey J.; Xu, Jixian; Sargent, Edward H.; Quan, Li Na; Kim, Dong Ha

    2015-04-06

    A simple two-step method was used to produce efficient planar organolead halide perovskite solar cells. Films produced using solely iodine containing precursors resulted in poor morphology and failed devices, whereas addition of chlorine to the process greatly improved morphology and resulted in dense, uniform perovskite films. This process was used to produce perovskite solar cells with a fullerene-based passivation layer. The hysteresis effect, to which planar perovskite devices are otherwise prone, was greatly suppressed through the use of this interface modifier. The combined techniques resulted in perovskite solar cells having a stable efficiency exceeding 11%. This straightforward fabrication procedure holds promise in development of various optoelectronic applications of planar perovskite films.

  12. Exhibition of Stochastic Resonance in Vestibular Perception

    NASA Technical Reports Server (NTRS)

    Galvan-Garza, R. C.; Clark, T. K.; Merfeld, D. M.; Bloomberg, J. J.; Oman, C. M.; Mulavara, A. P.

    2016-01-01

    Astronauts experience sensorimotor changes during spaceflight, particularly during G-transitions. Post flight sensorimotor changes include spatial disorientation, along with postural and gait instability that may degrade operational capabilities of the astronauts and endanger the crew. A sensorimotor countermeasure that mitigates these effects would improve crewmember safety and decrease risk. The goal of this research is to investigate the potential use of stochastic vestibular stimulation (SVS) as a technology to improve sensorimotor function. We hypothesize that low levels of SVS will improve sensorimotor perception through the phenomenon of stochastic resonance (SR), when the response of a nonlinear system to a weak input signal is enhanced by the application of a particular nonzero level of noise. This study aims to advance the development of SVS as a potential countermeasure by 1) demonstrating the exhibition of stochastic resonance in vestibular perception, a vital component of sensorimotor function, 2) investigating the repeatability of SR exhibition, and 3) determining the relative contribution of the semicircular canals (SCC) and otolith (OTO) organs to vestibular perceptual SR. A constant current stimulator was used to deliver bilateral bipolar SVS via electrodes placed on each of the mastoid processes, as previously done. Vestibular perceptual motion recognition thresholds were measured using a 6-degree of freedom MOOG platform and a 150 trial 3-down/1-up staircase procedure. In the first test session, we measured vestibular perceptual thresholds in upright roll-tilt at 0.2 Hz (SCC+OTO) with SVS ranging from 0-700 µA. In a second test session a week later, we re-measured roll-tilt thresholds with 0, optimal (from test session 1), and 1500 µA SVS levels. A subset of these subjects, plus naive subjects, participated in two additional test sessions in which we measured thresholds in supine roll-rotation at 0.2 Hz (SCC) and upright y-translation at 1 Hz

  13. Plant shoots exhibit synchronized oscillatory motions

    PubMed Central

    Ciszak, Marzena; Masi, Elisa; Baluška, František; Mancuso, Stefano

    2016-01-01

    ABSTRACT In animals, the ability to move has evolved as an important means of protection from predators and for enhancing nutrient uptake. In the animal kingdom, an individual's movements may become coordinated with those of other individuals that belong to the same group, which leads, for example, to the beautiful collective patterns that are observed in flocks of birds and schools of fish or in animal migration. Land plants, however, are fixed to the ground, which limits their movement and, apparently, their interactions and collective behaviors. We show that emergent maize plants grown in a group exhibit synchronized oscillatory motions that may be in-phase or anti-phase. These oscillations occur in short bursts and appear when the leaves rupture from the coleoptile tip. The appearance of these oscillations indicates an abrupt increase in the plant growth rate, which may be associated with a sudden change in the energy uptake for photosynthesis. Our results suggest that plant shoots behave as a complex network of biological oscillators, interacting through biophysical links, e.g. chemical substances or electric signals. PMID:27829981

  14. Agitated Honeybees Exhibit Pessimistic Cognitive Biases

    PubMed Central

    Bateson, Melissa; Desire, Suzanne; Gartside, Sarah E.; Wright, Geraldine A.

    2011-01-01

    Summary Whether animals experience human-like emotions is controversial and of immense societal concern [1–3]. Because animals cannot provide subjective reports of how they feel, emotional state can only be inferred using physiological, cognitive, and behavioral measures [4–8]. In humans, negative feelings are reliably correlated with pessimistic cognitive biases, defined as the increased expectation of bad outcomes [9–11]. Recently, mammals [12–16] and birds [17–20] with poor welfare have also been found to display pessimistic-like decision making, but cognitive biases have not thus far been explored in invertebrates. Here, we ask whether honeybees display a pessimistic cognitive bias when they are subjected to an anxiety-like state induced by vigorous shaking designed to simulate a predatory attack. We show for the first time that agitated bees are more likely to classify ambiguous stimuli as predicting punishment. Shaken bees also have lower levels of hemolymph dopamine, octopamine, and serotonin. In demonstrating state-dependent modulation of categorization in bees, and thereby a cognitive component of emotion, we show that the bees' response to a negatively valenced event has more in common with that of vertebrates than previously thought. This finding reinforces the use of cognitive bias as a measure of negative emotional states across species and suggests that honeybees could be regarded as exhibiting emotions. Video Abstract PMID:21636277

  15. Rotating pigment cells exhibit an intrinsic chirality.

    PubMed

    Yamanaka, Hiroaki; Kondo, Shigeru

    2015-01-01

    In multicellular organisms, cell properties, such as shape, size and function are important in morphogenesis and physiological functions. Recently, 'cellular chirality' has attracted attention as a cellular property because it can cause asymmetry in the bodies of animals. In recent in vitro studies, the left-right bias of cellular migration and of autonomous arrangement of cells under some specific culture conditions were discovered. However, it is difficult to identify the molecular mechanism underlying their intrinsic chirality because the left-right bias observed to date is subtle or is manifested in the stable orientation of cells. Here, we report that zebrafish (Danio rerio) melanophores exhibit clear cellular chirality by unidirectional counterclockwise rotational movement under isolated conditions without any special settings. The chirality is intrinsic to melanophores because the direction of the cellular rotation was not affected by the type of extracellular matrix. We further found that the cellular rotation was generated as a counter action of the clockwise movement of actin cytoskeleton. It suggested that the mechanism that directs actin cytoskeleton in the clockwise direction is pivotal for determining cellular chirality.

  16. Virtual Exhibition and Fruition of Archaeological Finds

    NASA Astrophysics Data System (ADS)

    Manferdini, A. M.; Garagnani, S.

    2011-09-01

    During the last two decades, since digital technologies have become more sophisticated in acquiring real data and building faithful copies of them, their improvements have suggested interesting applications in the field of valorisation of Historical, Cultural and Artistic Heritage, with significant consequences in the share and widespread of knowledge. But although several technologies and methodologies for 3d digitization have recently been developed and improved, the lack of a standard procedure and the costs connected to their use still doesn't encourage the systematic digital acquisition of wide collections and heritage. The aim of this paper is to show the state of the art of a project whose aim is to provide a methodology and a procedure to create digital reproductions of artefacts for Institutions called to preserve, manage and enhance the fruition of archaeological finds inside museums or through digital exhibitions. Our project's aim is to find the most suitable procedure to digitally acquire archaeo logical artefacts that usually have small dimensions and have very complex and detailed surfaces. Within our methodology, particular attention has been paid to the use of widely shared and open-source visualization systems that enhance the involvement of the user by emphasizing three-dimensional characteristics of artefacts through virtual reality.

  17. Plant shoots exhibit synchronized oscillatory motions.

    PubMed

    Ciszak, Marzena; Masi, Elisa; Baluška, František; Mancuso, Stefano

    2016-01-01

    In animals, the ability to move has evolved as an important means of protection from predators and for enhancing nutrient uptake. In the animal kingdom, an individual's movements may become coordinated with those of other individuals that belong to the same group, which leads, for example, to the beautiful collective patterns that are observed in flocks of birds and schools of fish or in animal migration. Land plants, however, are fixed to the ground, which limits their movement and, apparently, their interactions and collective behaviors. We show that emergent maize plants grown in a group exhibit synchronized oscillatory motions that may be in-phase or anti-phase. These oscillations occur in short bursts and appear when the leaves rupture from the coleoptile tip. The appearance of these oscillations indicates an abrupt increase in the plant growth rate, which may be associated with a sudden change in the energy uptake for photosynthesis. Our results suggest that plant shoots behave as a complex network of biological oscillators, interacting through biophysical links, e.g. chemical substances or electric signals.

  18. Quantum Nonlocal Boxes Exhibit Stronger Distillability

    NASA Astrophysics Data System (ADS)

    Høyer, Peter; Rashid, Jibran

    2013-06-01

    The hypothetical nonlocal box (NLB) proposed by Popescu and Rohrlich allows two spatially separated parties, Alice and Bob, to exhibit stronger than quantum correlations. If the generated correlations are weak, they can sometimes be distilled into a stronger correlation by repeated applications of the NLB. Motivated by the limited distillability of NLBs, we initiate here a study of the distillation of correlations for nonlocal boxes that output quantum states rather than classical bits (qNLBs). We propose a new protocol for distillation and show that it asymptotically distills a class of correlated quantum nonlocal boxes to the value (1)/(2)(3√ {3}+1) ≈ 3.098076, whereas in contrast, the optimal non-adaptive parity protocol for classical nonlocal boxes asymptotically distills only to the value 3.0. We show that our protocol is an optimal non-adaptive protocol for 1, 2 and 3 qNLB copies by constructing a matching dual solution for the associated primal semidefinite program (SDP). We conclude that qNLBs are a stronger resource for nonlocality than NLBs. The main premise that develops from this conclusion is that the NLB model is not the strongest resource to investigate the fundamental principles that limit quantum nonlocality. As such, our work provides strong motivation to reconsider the status quo of the principles that are known to limit nonlocal correlations under the framework of qNLBs rather than NLBs.

  19. [Exploration on academic thoughts of four medical families of acupuncture-moxibustion of the LING, YAN, SHI and SHENG in northern Zhejiang Province].

    PubMed

    Chen, Feng

    2013-12-01

    The academic origin and characteristics of medical families of acupuncture-moxibustion in northern Zhejiang Province were explored in this paper. With acupuncture-moxibustion characteristic of medical families in northern Zhejiang Province such as the LING (see text), the YAN (see text), the SHI (see text) and the SHENG (see text) analyzed and arranged, it was found out that taking the Internal Canon of Medicine as theory basis, their academic thoughts comprehensively absorbed acupuncture-moxibustion theories in all ages, and they continuously made innovations through constant practices, resulting in academic thoughts that focusing on application of acupuncture-moxibustion in clinic, using moxibustion for deficient illness and adopting acupuncture-moxibustion and Chinese herbs for severe and acute patients. The academic thoughts of medical families of acupuncture and moxibustion in northern Zhejiang Province are featured by unique acupoint selection and ma nipulation, thorough moxibustion methods and combined application of Chinese herbs and acupuncture-moxibustion, which is a clinical system of diagnosis and treatment with typical Jiangnan features.

  20. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    PubMed

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way.

  1. Marine bacteria exhibit a bipolar distribution.

    PubMed

    Sul, Woo Jun; Oliver, Thomas A; Ducklow, Hugh W; Amaral-Zettler, Linda A; Sogin, Mitchell L

    2013-02-05

    The microbial cosmopolitan dispersion hypothesis often invoked to explain distribution patterns driven by high connectivity of oceanographic water masses and widespread dispersal ability has never been rigorously tested. By using a global marine bacterial dataset and iterative matrix randomization simulation, we show that marine bacteria exhibit a significantly greater dispersal limitation than predicted by our null model using the "everything is everywhere" tenet with no dispersal limitation scenario. Specifically, marine bacteria displayed bipolar distributions (i.e., species occurring exclusively at both poles and nowhere else) significantly less often than in the null model. Furthermore, we observed fewer taxa present in both hemispheres but more taxa present only in a single hemisphere than expected under the null model. Each of these trends diverged further from the null expectation as the compared habitats became more geographically distant but more environmentally similar. Our meta-analysis supported a latitudinal gradient in bacterial diversity with higher richness at lower latitudes, but decreased richness toward the poles. Bacteria in the tropics also demonstrated narrower latitudinal ranges at lower latitudes and relatively larger ranges in higher latitudes, conforming to the controversial macroecological pattern of the "Rapoport rule." Collectively, our findings suggest that bacteria follow biogeographic patterns more typical of macroscopic organisms, and that dispersal limitation, not just environmental selection, likely plays an important role. Distributions of microbes that deliver critical ecosystem services, particularly those in polar regions, may be vulnerable to the same impacts that environmental stressors, climate warming, and degradation in habitat quality are having on biodiversity in animal and plant species.

  2. Waves in geomaterials exhibiting negative stiffness behaviour

    NASA Astrophysics Data System (ADS)

    Esin, Maxim; Dyskin, Arcady; Pasternak, Elena

    2016-04-01

    Negative stiffness denotes the type of material behaviour when the force applied to the body decreases the body's deformation increases. Some geomaterials, for instance, rocks, demonstrate behaviour of this type at certain loads: during the compression tests the loading curves exhibit descending branch (post-peak softening). One of the possible mechanisms of the negative stiffness appearance in geomaterials is rotation of non-spherical grains. It is important to emphasize that in this case the descending branch may be reversible given that the testing machine is stiff enough (in general case it means an importance of boundary conditions). Existence of geomaterials with a negative modulus associated with rotations may have significant importance. In particular, important is understanding of the wave propagation in such materials. We study the stability of geomaterials with negative stiffness inclusions and wave propagation in it using two approaches: Cosserat continuum and discrete mass-spring models. In both cases we consider the rotational degrees of freedom in addition to the conventional translational ones. We show that despite non positiveness of the energy the materials with negative stiffness elements can be stable if certain conditions are met. In the case of Cosserat continuum the Cosserat shear modulus (the modulus relating the non-symmetrical part of shear stress and internal rotations) is allowed to assume negative values as long as its value does not exceed the value of the standard (positive) shear modulus. In the case of discrete mass-spring systems (with translational and rotational springs) the concentration of negative stiffness springs and the absolute values of negative spring stiffness are limited. The critical concentration when the system loses stability and the amplitude of the oscillations tends to infinity is equal to 1/2 and 3/5 for two- and three-dimensional cases respectively.

  3. Naturally segregating loci exhibit epistasis for fitness

    PubMed Central

    Monnahan, Patrick J.; Kelly, John K.

    2015-01-01

    The extent to which gene interaction or epistasis contributes to fitness variation within populations remains poorly understood, despite its importance to a myriad of evolutionary questions. Here, we report a multi-year field study estimating fitness of Mimulus guttatus genetic lines in which pairs of naturally segregating loci exist in an otherwise uniform background. An allele at QTL x5b—a locus originally mapped for its effect on flower size—positively affects survival if combined with one genotype at quantitative trait locus x10a (aa) but has negative effects when combined with the other genotypes (Aa and AA). The viability differences between genotypes parallel phenotypic differences for the time and node at which a plant flowers. Viability is negatively correlated with fecundity across genotypes, indicating antagonistic pleiotropy for fitness components. This trade-off reduces the genetic variance for total fitness relative to the individual fitness components and thus may serve to maintain variation. Additionally, we find that the effects of each locus and their interaction often vary with the environment. PMID:26246336

  4. Modified carbon surfaces as "organic electrodes" that exhibit conductance switching.

    PubMed

    Solak, Ali Osman; Eichorst, Laura R; Clark, William J; McCreery, Richard L

    2003-01-15

    Glassy carbon (GC) surfaces modified with monolayers of biphenyl and nitrobiphenyl molecules were examined as voltammetric electrodes for ferrocene, benzoquinone, and tetracyanoquinodimethane electrochemistry in acetonitrile. The modified electrodes exhibited slower electron transfer than unmodified GC, by factors that varied with the monolayer and redox system. However, after a negative potential excursion to approximately -2.0 V versus Ag+/Ag, the modified electrodes exhibited much faster electron-transfer kinetics, approaching those observed on unmodified GC. The effect is attributed to an apparently irreversible structural change in the biphenyl or nitrobiphenyl monolayer, which increases the rate of electron tunneling. The transition to the "ON" state is associated with electron injection into the monolayer similar to that observed in previous spectroscopic investigations and causes a significant decrease in the calculated HOMO-LUMO gap for the monolayer molecule. Once the monolayer is switched ON, it supports rapid electron exchange with outer-sphere redox systems, but not with dopamine, which requires adsorption to the GC surface. The increase in electron-transfer rate with electron injection is consistent with an increase in electron tunneling rate through the monolayer, caused by a significant decrease in tunneling barrier height. The ON electrode can reduce biphenyl- or nitrobiphenyldiazonium reagent in solution to permit formation of a second modification layer of biphenyl or nitrobiphenyl molecules. This "double derivatization" procedure was used to prepare tetraphenyl- and nitrotetraphenyl-modified electrodes, which exhibit significantly slower electron transfer than their biphenyl and nitrobiphenyl counterparts. A "switching" electrode may have useful properties for electroanalytical applications and possibly in electrocatalysis. In addition, the ON state represents an "organic electrode" in which electron transfer occurs at an interface between an

  5. Liposomal nanoparticles encapsulating iloprost exhibit enhanced vasodilation in pulmonary arteries

    PubMed Central

    Jain, Pritesh P; Leber, Regina; Nagaraj, Chandran; Leitinger, Gerd; Lehofer, Bernhard; Olschewski, Horst; Olschewski, Andrea; Prassl, Ruth; Marsh, Leigh M

    2014-01-01

    Prostacyclin analogues are standard therapeutic options for vasoconstrictive diseases, including pulmonary hypertension and Raynaud’s phenomenon. Although effective, these treatment strategies are expensive and have several side effects. To improve drug efficiency, we tested liposomal nanoparticles as carrier systems. In this study, we synthesized liposomal nanoparticles tailored for the prostacyclin analogue iloprost and evaluated their pharmacologic efficacy on mouse intrapulmonary arteries, using a wire myograph. The use of cationic lipids, stearylamine, or 1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane (DOTAP) in liposomes promoted iloprost encapsulation to at least 50%. The addition of cholesterol modestly reduced iloprost encapsulation. The liposomal nanoparticle formulations were tested for toxicity and pharmacologic efficacy in vivo and ex vivo, respectively. The liposomes did not affect the viability of human pulmonary artery smooth muscle cells. Compared with an equivalent concentration of free iloprost, four out of the six polymer-coated liposomal formulations exhibited significantly enhanced vasodilation of mouse pulmonary arteries. Iloprost that was encapsulated in liposomes containing the polymer polyethylene glycol exhibited concentration-dependent relaxation of arteries. Strikingly, half the concentration of iloprost in liposomes elicited similar pharmacologic efficacy as nonencapsulated iloprost. Cationic liposomes can encapsulate iloprost with high efficacy and can serve as potential iloprost carriers to improve its therapeutic efficacy. PMID:25045260

  6. Liposomal nanoparticles encapsulating iloprost exhibit enhanced vasodilation in pulmonary arteries.

    PubMed

    Jain, Pritesh P; Leber, Regina; Nagaraj, Chandran; Leitinger, Gerd; Lehofer, Bernhard; Olschewski, Horst; Olschewski, Andrea; Prassl, Ruth; Marsh, Leigh M

    2014-01-01

    Prostacyclin analogues are standard therapeutic options for vasoconstrictive diseases, including pulmonary hypertension and Raynaud's phenomenon. Although effective, these treatment strategies are expensive and have several side effects. To improve drug efficiency, we tested liposomal nanoparticles as carrier systems. In this study, we synthesized liposomal nanoparticles tailored for the prostacyclin analogue iloprost and evaluated their pharmacologic efficacy on mouse intrapulmonary arteries, using a wire myograph. The use of cationic lipids, stearylamine, or 1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane (DOTAP) in liposomes promoted iloprost encapsulation to at least 50%. The addition of cholesterol modestly reduced iloprost encapsulation. The liposomal nanoparticle formulations were tested for toxicity and pharmacologic efficacy in vivo and ex vivo, respectively. The liposomes did not affect the viability of human pulmonary artery smooth muscle cells. Compared with an equivalent concentration of free iloprost, four out of the six polymer-coated liposomal formulations exhibited significantly enhanced vasodilation of mouse pulmonary arteries. Iloprost that was encapsulated in liposomes containing the polymer polyethylene glycol exhibited concentration-dependent relaxation of arteries. Strikingly, half the concentration of iloprost in liposomes elicited similar pharmacologic efficacy as nonencapsulated iloprost. Cationic liposomes can encapsulate iloprost with high efficacy and can serve as potential iloprost carriers to improve its therapeutic efficacy.

  7. Cushing's syndrome mutant PKAL205R exhibits altered substrate specificity

    DOE PAGES

    Lubner, Joshua M.; Dodge-Kafka, Kimberly L.; Carlson, Cathrine R.; ...

    2017-02-01

    The PKAL205R hotspot mutation has been implicated in Cushing's syndrome through hyperactive gain-of-function PKA signaling; however, its influence on substrate specificity has not been investigated. Here, we employ the Proteomic Peptide Library (ProPeL) approach to create high-resolution models for PKAWT and PKA L205R substrate specificity. We reveal that the L205R mutation reduces canonical hydrophobic preference at the substrate P + 1 position, and increases acidic preference in downstream positions. Using these models, we designed peptide substrates that exhibit altered selectivity for specific PKA variants, and demonstrate the feasibility of selective PKAL205R loss-of-function signaling. Through these results, we suggest that substratemore » rewiring may contribute to Cushing's syndrome disease etiology, and introduce a powerful new paradigm for investigating mutation-induced kinase substrate rewiring in human disease.« less

  8. Developing Visualization Tools for Geographic Literacy in a Museum Exhibit: An Interdisciplinary Collaboration

    ERIC Educational Resources Information Center

    Bloodworth, Gina; Petersen, Naomi Jeffery

    2011-01-01

    As a result of reduced formal instruction and reduced direct experience in the natural environment, students suffer from a deficiency in geographic literacy. Informal learning environments, such as a model railroad exhibit at a history museum, can be exploited to introduce key geographic concepts (e.g., scalar compression, landscape…

  9. Development of Exhibit on Arctic Climate Change Called The Arctic: A Friend Acting Strangely Exhibition

    SciTech Connect

    Stauffer, Barbara W.

    2006-04-01

    The exhibition, The Arctic: A Friend Acting Strangely, was developed at the Smithsonian Institution’s National Museum of Natural History (NMNH) as a part of the museum’s Forces of Change exhibit series on global change. It opened to the public in Spring 2006, in conjunction with another Forces of Change exhibit on the Earth’s atmosphere called Change Is in the Air. The exhibit was a 2000 square-foot presentation that explored the forces and consequences of the changing Arctic as documented by scientists and native residents alike. Native peoples of the Arctic have always lived with year-to-year fluctuations in weather and ice conditions. In recent decades, they have witnessed that the climate has become unpredictable, the land and sea unfamiliar. An elder in Arctic Canada recently described the weather as uggianaqtuq —an Inuit word that can suggest strange, unexpected behavior, sometimes described as that of “a friend acting strangely.” Scientists too have been documenting dramatic changes in the Arctic. Air temperatures have warmed over most—though not all—of the Arctic since the 1950s; Arctic precipitation may have increased by as much as 8%; seasonal melting of the Greenland Ice Sheet has increased on average by 16% since 1979; polar-orbiting satellites have measured a 15¬–20% decline in sea ice extent since the 1970s; aircraft reconnaissance and ship observations show a steady decrease in sea ice since the 1950s. In response to this warming, plant distributions have begun to shift and animals are changing their migration routes. Some of these changes may have beneficial effects while others may bring hardship or have costly implications. And, many scientists consider arctic change to be a ‘bell-weather’ for large-scale changes in other regions of the world. The exhibition included text, photos artifacts, hands-on interactives and other exhibitry that illustrated the changes being documented by indigenous people and scientists alike.

  10. 37 CFR 1.95 - Copies of exhibits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions Models, Exhibits, Specimens § 1.95 Copies of exhibits. Copies of models or other physical exhibits will not ordinarily be furnished by the Office, and any model or exhibit in an application or patent shall not be taken from...

  11. 37 CFR 1.95 - Copies of exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions Models, Exhibits, Specimens § 1.95 Copies of exhibits. Copies of models or other physical exhibits will not ordinarily be furnished by the Office, and any model or exhibit in an application or patent shall not be taken from...

  12. 29 CFR 2204.202 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Net worth exhibit. 2204.202 Section 2204.202 Labor... COMMISSION Information Required From Applicants § 2204.202 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant as of the date specified by § 2204.105(c). The exhibit...

  13. 29 CFR 2204.202 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Net worth exhibit. 2204.202 Section 2204.202 Labor... COMMISSION Information Required From Applicants § 2204.202 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant as of the date specified by § 2204.105(c). The exhibit...

  14. 29 CFR 2204.202 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Net worth exhibit. 2204.202 Section 2204.202 Labor... COMMISSION Information Required From Applicants § 2204.202 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant as of the date specified by § 2204.105(c). The exhibit...

  15. 29 CFR 2204.202 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Net worth exhibit. 2204.202 Section 2204.202 Labor... COMMISSION Information Required From Applicants § 2204.202 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant as of the date specified by § 2204.105(c). The exhibit...

  16. Tracing the locality of prisoners and workers at the Mausoleum of Qin Shi Huang: First Emperor of China (259-210 BC)

    NASA Astrophysics Data System (ADS)

    Ma, Ying; Fuller, Benjamin T.; Sun, Weigang; Hu, Songmei; Chen, Liang; Hu, Yaowu; Richards, Michael P.

    2016-06-01

    The mausoleum complex of the First Emperor of China, Qin Shi Huang (259-210 BC), is one of the most famous and important archaeological sites in China, yet questions remain as to how it was constructed and by whom. Here we present isotopic results of individuals from the Liyi (n = 146) and Shanren sites (n = 14), both associated with the mausoleum complex. Those buried at Liyi represent the local workers/inhabitants of the Qin population, and the δ13C (‑8.7 ± 1.5%) and δ15N (10.3 ± 0.7%) values indicate that they consumed predominately millet and/or domestic animals fed millet. In contrast, the Shanren individuals were prisoners forced to construct the mausoleum (found buried haphazardly in a mass grave and some in iron leg shackles), and their δ13C (‑15.4 ± 2.9%) and δ15N (8.0 ± 0.6%) results indicate a more mixed C3/C4 diet, with possibly less domestic animals and more wild game protein consumed. This pattern of decreased millet consumption is also characteristic of archaeological sites from southern China, and possible evidence the Shanren prisoners originated from this region (possibly the ancient Chu state located in modern day Hubei Province and parts of Hunan and Anhui Provinces). Further, this finding is in agreement with historical sources and is supported by previous ancient DNA evidence that the mausoleum workers had diverse origins, with many genetically related to southern Chinese groups.

  17. Tracing the locality of prisoners and workers at the Mausoleum of Qin Shi Huang: First Emperor of China (259-210 BC)

    PubMed Central

    Ma, Ying; Fuller, Benjamin T.; Sun, Weigang; Hu, Songmei; Chen, Liang; Hu, Yaowu; Richards, Michael P.

    2016-01-01

    The mausoleum complex of the First Emperor of China, Qin Shi Huang (259-210 BC), is one of the most famous and important archaeological sites in China, yet questions remain as to how it was constructed and by whom. Here we present isotopic results of individuals from the Liyi (n = 146) and Shanren sites (n = 14), both associated with the mausoleum complex. Those buried at Liyi represent the local workers/inhabitants of the Qin population, and the δ13C (−8.7 ± 1.5%) and δ15N (10.3 ± 0.7%) values indicate that they consumed predominately millet and/or domestic animals fed millet. In contrast, the Shanren individuals were prisoners forced to construct the mausoleum (found buried haphazardly in a mass grave and some in iron leg shackles), and their δ13C (−15.4 ± 2.9%) and δ15N (8.0 ± 0.6%) results indicate a more mixed C3/C4 diet, with possibly less domestic animals and more wild game protein consumed. This pattern of decreased millet consumption is also characteristic of archaeological sites from southern China, and possible evidence the Shanren prisoners originated from this region (possibly the ancient Chu state located in modern day Hubei Province and parts of Hunan and Anhui Provinces). Further, this finding is in agreement with historical sources and is supported by previous ancient DNA evidence that the mausoleum workers had diverse origins, with many genetically related to southern Chinese groups. PMID:27253909

  18. 7 CFR Exhibit C to Subpart C of... - Checklist of Visual Exhibits and Documentation for RRH, RCH, and LH Proposals

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Checklist of Visual Exhibits and Documentation for... Part 1924—Checklist of Visual Exhibits and Documentation for RRH, RCH, and LH Proposals U.S. Department... exhibit lists visual exhibits and documentation necessary for FmHA or its successor agency under...

  19. Prevalence of swallowing and speech problems in daily life after chemoradiation for head and neck cancer based on cut-off scores of the patient-reported outcome measures SWAL-QOL and SHI.

    PubMed

    Rinkel, Rico N; Verdonck-de Leeuw, Irma M; Doornaert, Patricia; Buter, Jan; de Bree, Remco; Langendijk, Johannes A; Aaronson, Neil K; Leemans, C René

    2016-07-01

    The objective of this study is to assess swallowing and speech outcome after chemoradiation therapy for head and neck cancer, based on the patient-reported outcome measures Swallowing Quality of Life Questionnaire (SWAL-QOL) and Speech Handicap Index (SHI), both provided with cut-off scores. This is a cross-sectional study. Department of Otolaryngology/Head and Neck Surgery of a University Medical Center. Sixty patients, 6 months to 5 years after chemoradiation for head and neck squamous cell carcinoma. Swallowing Quality of Life Questionnaire (SWAL-QOL) and SHI, both validated in Dutch and provided with cut-off scores. Associations were tested between the outcome measures and independent variables (age, gender, tumor stage and site, and radiotherapy technique, time since treatment, comorbidity and food intake). Fifty-two patients returned the SWAL-QOL and 47 the SHI (response rate 87 and 78 %, respectively). Swallowing and speech problems were present in 79 and 55 %, respectively. Normal food intake was noticed in 45, 35 % had a soft diet and 20 % tube feeding. Patients with soft diet and tube feeding reported more swallowing problems compared to patients with normal oral intake. Tumor subsite was significantly associated with swallowing outcome (less problems in larynx/hypopharynx compared to oral/oropharynx). Radiation technique was significantly associated with psychosocial speech problems (less problems in patients treated with IMRT). Swallowing and (to a lesser extent) speech problems in daily life are frequently present after chemoradiation therapy for head and neck cancer. Future prospective studies will give more insight into the course of speech and swallowing problems after chemoradiation and into efficacy of new radiation techniques and swallowing and speech rehabilitation programs.

  20. The Pahrump Valley Museum Yucca Mountain History Exhibit - 12389

    SciTech Connect

    Voegele, Michael; McCracken, Robert; Herrera, Troy

    2012-07-01

    As part of its management of the Yucca Mountain project, the Department of Energy maintained several information centers to provide public access to information about the status of the Yucca Mountain project. Those information centers contained numerous displays, historical information, and served as the location for the Department's outreach activities. As the Department of Energy dealt with reduced budgets in 2009 following the Obama Administration's intent to terminate the program, it shut down its information centers. Nye County considered it important to maintain a public information center where people would be able to find information about what was happening with the Yucca Mountain project. Initially the Nye County assumed responsibility for the information center in Pahrump; eventually the County made a decision to move that information center into an expansion of the existing Pahrump Valley Museum. Nye County undertook an effort to update the information about the Yucca Mountain project and modernize the displays. A parallel effort to create a source of historical information where people could find out about the Yucca Mountain project was undertaken. To accompany the Yucca Mountain exhibits in the Pahrump Valley Museum, Nye County also sponsored a series of interviews to document, through oral histories, as much information about the Yucca Mountain project as could be found in these interviews. The paper presents an overview of the Yucca Mountain exhibits in the Pahrump Valley Museum, and the accompanying oral histories. An important conclusion that can be drawn from the interviews is that construction of a repository in Nevada should have been conceptualized as but the first step in transforming the economy of central Nevada by turning part of the Nevada National Security Site and adjoining area into a world-class energy production and energy research center. (authors)

  1. 48 CFR 204.7105 - Contract exhibits and attachments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... attachments. 204.7105 Section 204.7105 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... 204.7105 Contract exhibits and attachments. Follow the procedures at PGI 204.7105 for use and numbering of contract exhibits and attachments....

  2. 32 CFR 705.25 - Navy Exhibit Center.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AND OFFICIAL RECORDS PUBLIC AFFAIRS REGULATIONS § 705.25 Navy Exhibit Center. (a) The center is a... mission is to produce, transport and display U.S. Navy exhibits throughout the United States. It...

  3. 32 CFR 705.25 - Navy Exhibit Center.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... AND OFFICIAL RECORDS PUBLIC AFFAIRS REGULATIONS § 705.25 Navy Exhibit Center. (a) The center is a... mission is to produce, transport and display U.S. Navy exhibits throughout the United States. It...

  4. 32 CFR 705.25 - Navy Exhibit Center.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... AND OFFICIAL RECORDS PUBLIC AFFAIRS REGULATIONS § 705.25 Navy Exhibit Center. (a) The center is a... mission is to produce, transport and display U.S. Navy exhibits throughout the United States. It...

  5. Weight lifting can facilitate appreciative comprehension for museum exhibits.

    PubMed

    Yamada, Yuki; Harada, Shinya; Choi, Wonje; Fujino, Rika; Tokunaga, Akinobu; Gao, Yueyun; Miura, Kayo

    2014-01-01

    Appreciation of exhibits in a museum can be equated to a virtual experience of lives in the contexts originally surrounding the exhibits. Here we focus on the importance of weight information, and hence tested whether experiencing a weight during museum exhibit appreciation affects the beholders' satisfaction and recognition memory for the exhibits. An experiment was performed at a museum exhibiting skeletal preparations of animals. We used nine preparations and prepared four weight stimuli as weight cues in accordance with the actual weight of four of the preparations: Remaining five preparations was displayed without weight stimuli. In the cued condition, participants were asked to lift up the weight stimuli during their observation of the four exhibits. In the uncued condition, participants observed the exhibits without touching the weight stimuli. After observation of the exhibits, the participants responded to a questionnaire that measured their impressions of the exhibits and the museum, and performed a recognition test on the exhibits. Results showed that memory performance was better and viewing duration was longer with weight lifting instruction than without instruction. A factor analysis on the questionnaires revealed four factors (likeability, contentment, value, and quality). A path analysis showed indirect effects of viewing duration on memory performance and willingness-to-pay (WTP) for the museum appreciation through the impression factors. Our findings provide insight into a new interactive exhibition that enables long appreciation producing positive effects on visitors' impression, memory, and value estimation for exhibits.

  6. 14 CFR Appendix to Part 1274 - Listing of Exhibits

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Listing of Exhibits Appendix to Part 1274 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS WITH COMMERCIAL FIRMS Pt. 1274, App. Appendix to Part 1274—Listing of Exhibits Exhibit A to Part...

  7. 14 CFR Appendix to Part 1274 - Listing of Exhibits

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Listing of Exhibits Appendix to Part 1274 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION COOPERATIVE AGREEMENTS WITH COMMERCIAL FIRMS Pt. 1274, App. Appendix to Part 1274—Listing of Exhibits Exhibit A to Part...

  8. 14 CFR Appendix to Subpart A of... - Listing of Exhibits

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Listing of Exhibits Appendix to Subpart A of Part 1260 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Pt. 1260, Subpt. A, App. Appendix to Subpart A of Part 1260—Listing of Exhibits Exhibit...

  9. A Phenomenological Investigation of Science Center Exhibition Developers' Expertise Development

    ERIC Educational Resources Information Center

    Young, Denise L.

    2012-01-01

    The purpose of this study was to examine the exhibition developer role in the context of United States (U.S.) science centers, and more specifically, to investigate the way science center exhibition developers build their professional expertise. This research investigated how successfully practicing exhibition developers described their current…

  10. African Past: Migrant Present. A Guide to the Exhibition.

    ERIC Educational Resources Information Center

    Twining, Mary Arnold; Roark-Calnek, Sue

    This exhibit guide describes an exhibition of African folk arts produced by seasonal migrant farmworkers in western New York State. Workers come from the American South, Haiti, Puerto Rico, and Jamaica. The exhibition pieces were collected through the BOCES Geneseo Migrant Center's Folk Arts Program and Creative Artists Migrant Program Services…

  11. A Major Children's Educational Art Exhibit: An Evaluative Case Study.

    ERIC Educational Resources Information Center

    Schlenk, George W.; Shrock, Sharon A.

    Results of a case study of an exhibit of art and artifacts designed for children are presented. The focus of the study was to apply the principles of instructional-message design to the evaluation of the exhibit. The exhibit, "Art Inside Out: Exploring Art and Culture through Time," was displayed at the Art Institute of Chicago. Textual…

  12. 76 FR 68808 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... Exhibition Determinations: ``Transition to Christianity: Art of Late Antiquity, 3rd-7th Century AD'' SUMMARY... objects to be included in the exhibition ``Transition to Christianity: Art of Late Antiquity, 3rd-7th Century AD,'' imported from abroad for temporary exhibition within the United States, are of...

  13. 49 CFR 826.22 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Net worth exhibit. 826.22 Section 826.22... Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the net worth of the applicant...

  14. 49 CFR 6.19 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Net worth exhibit. 6.19 Section 6.19... PROCEEDINGS Information Required from Applicants § 6.19 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant and any affiliates (as defined in this part) when...

  15. 45 CFR 13.11 - Net worth exhibits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Net worth exhibits. 13.11 Section 13.11 Public... TO JUSTICE ACT IN AGENCY PROCEEDINGS Information Required from Applicants § 13.11 Net worth exhibits. (a) Each applicant must provide with its application a detailed exhibit showing the net worth of...

  16. 31 CFR 6.9 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Net worth exhibit. 6.9 Section 6.9... EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 6.9 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  17. 17 CFR 201.42 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Net worth exhibit. 201.42... Regulations Pertaining to the Equal Access to Justice Act § 201.42 Net worth exhibit. (a) Each applicant... a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  18. 17 CFR 201.42 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Net worth exhibit. 201.42... Regulations Pertaining to the Equal Access to Justice Act § 201.42 Net worth exhibit. (a) Each applicant... a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  19. 31 CFR 6.9 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Net worth exhibit. 6.9 Section 6.9... EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 6.9 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  20. 45 CFR 13.11 - Net worth exhibits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Net worth exhibits. 13.11 Section 13.11 Public... TO JUSTICE ACT IN AGENCY PROCEEDINGS Information Required from Applicants § 13.11 Net worth exhibits. (a) Each applicant must provide with its application a detailed exhibit showing the net worth of...

  1. 39 CFR 960.10 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Net worth exhibit. 960.10 Section 960.10 Postal... JUSTICE ACT IN POSTAL SERVICE PROCEEDINGS Information Required From Applicants § 960.10 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  2. 12 CFR 1071.201 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Net worth exhibit. 1071.201 Section 1071.201... Information Required from Applicants § 1071.201 Net worth exhibit. (a) The application shall also include a detailed exhibit showing that the applicant's net worth did not exceed $2 million (if an individual) or...

  3. 12 CFR 625.11 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Net worth exhibit. 625.11 Section 625.11 Banks... EXPENSES UNDER THE EQUAL ACCESS TO JUSTICE ACT Applicant Information Required § 625.11 Net worth exhibit... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  4. 49 CFR 826.22 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Net worth exhibit. 826.22 Section 826.22... Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the net worth of the applicant...

  5. 45 CFR 13.11 - Net worth exhibits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Net worth exhibits. 13.11 Section 13.11 Public... TO JUSTICE ACT IN AGENCY PROCEEDINGS Information Required from Applicants § 13.11 Net worth exhibits. (a) Each applicant must provide with its application a detailed exhibit showing the net worth of...

  6. 5 CFR 2610.202 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Net worth exhibit. 2610.202 Section 2610... THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 2610.202 Net worth exhibit. (a... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  7. 10 CFR 12.202 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Net worth exhibit. 12.202 Section 12.202 Energy NUCLEAR... Required From Applicants § 12.202 Net worth exhibit. (a) Each applicant, except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the...

  8. 17 CFR 201.42 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Net worth exhibit. 201.42... Regulations Pertaining to the Equal Access to Justice Act § 201.42 Net worth exhibit. (a) Each applicant... a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  9. 7 CFR 1.191 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Net worth exhibit. 1.191 Section 1.191 Agriculture... § 1.191 Net worth exhibit. (a) An applicant, except a qualified tax-exempt organization or cooperative association, must provide with its application a detailed exhibit showing the net worth of the applicant...

  10. 17 CFR 201.42 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Net worth exhibit. 201.42... Regulations Pertaining to the Equal Access to Justice Act § 201.42 Net worth exhibit. (a) Each applicant... a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  11. 17 CFR 148.12 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Net worth exhibit. 148.12... Required from Applicants § 148.12 Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the...

  12. 39 CFR 960.10 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Net worth exhibit. 960.10 Section 960.10 Postal... JUSTICE ACT IN POSTAL SERVICE PROCEEDINGS Information Required From Applicants § 960.10 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  13. 7 CFR 1.191 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Net worth exhibit. 1.191 Section 1.191 Agriculture... § 1.191 Net worth exhibit. (a) An applicant, except a qualified tax-exempt organization or cooperative association, must provide with its application a detailed exhibit showing the net worth of the applicant...

  14. 31 CFR 6.9 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Net worth exhibit. 6.9 Section 6.9... EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 6.9 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  15. 45 CFR 13.11 - Net worth exhibits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Net worth exhibits. 13.11 Section 13.11 Public... TO JUSTICE ACT IN AGENCY PROCEEDINGS Information Required from Applicants § 13.11 Net worth exhibits. (a) Each applicant must provide with its application a detailed exhibit showing the net worth of...

  16. 19 CFR 212.11 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Net worth exhibit. 212.11 Section 212.11 Customs... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 212.11 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  17. 49 CFR 6.19 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Net worth exhibit. 6.19 Section 6.19... PROCEEDINGS Information Required from Applicants § 6.19 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant and any affiliates (as defined in this part) when...

  18. 12 CFR 1071.201 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 9 2014-01-01 2014-01-01 false Net worth exhibit. 1071.201 Section 1071.201... Information Required from Applicants § 1071.201 Net worth exhibit. (a) The application shall also include a detailed exhibit showing that the applicant's net worth did not exceed $2 million (if an individual) or...

  19. 7 CFR 1.191 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Net worth exhibit. 1.191 Section 1.191 Agriculture... § 1.191 Net worth exhibit. (a) An applicant, except a qualified tax-exempt organization or cooperative association, must provide with its application a detailed exhibit showing the net worth of the applicant...

  20. 49 CFR 826.22 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Net worth exhibit. 826.22 Section 826.22... Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the net worth of the applicant...

  1. 12 CFR 625.11 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Net worth exhibit. 625.11 Section 625.11 Banks... EXPENSES UNDER THE EQUAL ACCESS TO JUSTICE ACT Applicant Information Required § 625.11 Net worth exhibit... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  2. 5 CFR 2610.202 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Net worth exhibit. 2610.202 Section 2610... THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 2610.202 Net worth exhibit. (a... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  3. 39 CFR 960.10 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Net worth exhibit. 960.10 Section 960.10 Postal... JUSTICE ACT IN POSTAL SERVICE PROCEEDINGS Information Required From Applicants § 960.10 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  4. 10 CFR 12.202 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Net worth exhibit. 12.202 Section 12.202 Energy NUCLEAR... Required From Applicants § 12.202 Net worth exhibit. (a) Each applicant, except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the...

  5. 5 CFR 2610.202 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Net worth exhibit. 2610.202 Section 2610... THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 2610.202 Net worth exhibit. (a... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  6. 12 CFR 625.11 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Net worth exhibit. 625.11 Section 625.11 Banks... EXPENSES UNDER THE EQUAL ACCESS TO JUSTICE ACT Applicant Information Required § 625.11 Net worth exhibit... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  7. 39 CFR 960.10 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Net worth exhibit. 960.10 Section 960.10 Postal... JUSTICE ACT IN POSTAL SERVICE PROCEEDINGS Information Required From Applicants § 960.10 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  8. 7 CFR 1.191 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Net worth exhibit. 1.191 Section 1.191 Agriculture... § 1.191 Net worth exhibit. (a) An applicant, except a qualified tax-exempt organization or cooperative association, must provide with its application a detailed exhibit showing the net worth of the applicant...

  9. 49 CFR 826.22 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Net worth exhibit. 826.22 Section 826.22... Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the net worth of the applicant...

  10. 17 CFR 148.12 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Net worth exhibit. 148.12... Required from Applicants § 148.12 Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the...

  11. 49 CFR 1016.202 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Net worth exhibit. 1016.202 Section 1016.202... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS Information Required From Applicants § 1016.202 Net worth exhibit. (a) Each applicant must provide with its application a detailed exhibit showing the...

  12. 49 CFR 1016.202 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Net worth exhibit. 1016.202 Section 1016.202... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS Information Required From Applicants § 1016.202 Net worth exhibit. (a) Each applicant must provide with its application a detailed exhibit showing the...

  13. 14 CFR § 1262.202 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Net worth exhibit. § 1262.202 Section Â... ACT IN AGENCY PROCEEDINGS Information Required From Applicants § 1262.202 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defiined...

  14. 12 CFR 625.11 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Net worth exhibit. 625.11 Section 625.11 Banks... EXPENSES UNDER THE EQUAL ACCESS TO JUSTICE ACT Applicant Information Required § 625.11 Net worth exhibit... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  15. 49 CFR 1016.202 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Net worth exhibit. 1016.202 Section 1016.202... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS Information Required From Applicants § 1016.202 Net worth exhibit. (a) Each applicant must provide with its application a detailed exhibit showing the...

  16. 49 CFR 826.22 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Net worth exhibit. 826.22 Section 826.22... Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the net worth of the applicant...

  17. 19 CFR 212.11 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Net worth exhibit. 212.11 Section 212.11 Customs... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 212.11 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  18. 19 CFR 212.11 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Net worth exhibit. 212.11 Section 212.11 Customs... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 212.11 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  19. 49 CFR 6.19 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Net worth exhibit. 6.19 Section 6.19... PROCEEDINGS Information Required from Applicants § 6.19 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant and any affiliates (as defined in this part) when...

  20. 49 CFR 1016.202 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Net worth exhibit. 1016.202 Section 1016.202... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS Information Required From Applicants § 1016.202 Net worth exhibit. (a) Each applicant must provide with its application a detailed exhibit showing the...

  1. 19 CFR 212.11 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Net worth exhibit. 212.11 Section 212.11 Customs... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 212.11 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  2. 17 CFR 201.42 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Net worth exhibit. 201.42... Regulations Pertaining to the Equal Access to Justice Act § 201.42 Net worth exhibit. (a) Each applicant... a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  3. 31 CFR 6.9 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Net worth exhibit. 6.9 Section 6.9... EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 6.9 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  4. 31 CFR 6.9 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Net worth exhibit. 6.9 Section 6.9... EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 6.9 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  5. 49 CFR 6.19 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Net worth exhibit. 6.19 Section 6.19... PROCEEDINGS Information Required from Applicants § 6.19 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant and any affiliates (as defined in this part) when...

  6. 5 CFR 2610.202 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Net worth exhibit. 2610.202 Section 2610... THE EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 2610.202 Net worth exhibit. (a... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  7. 49 CFR 1016.202 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Net worth exhibit. 1016.202 Section 1016.202... BY PARTIES TO BOARD ADJUDICATORY PROCEEDINGS Information Required From Applicants § 1016.202 Net worth exhibit. (a) Each applicant must provide with its application a detailed exhibit showing the...

  8. 47 CFR 1.1512 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Net worth exhibit. 1.1512 Section 1.1512... Applicants § 1.1512 Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the net worth of...

  9. 14 CFR 1262.202 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Net worth exhibit. 1262.202 Section 1262... AGENCY PROCEEDINGS Information Required From Applicants § 1262.202 Net worth exhibit. (a) Each applicant... detailed exhibit showing the net worth of the applicant and any affiliates (as defiined in §...

  10. 12 CFR 625.11 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Net worth exhibit. 625.11 Section 625.11 Banks... EXPENSES UNDER THE EQUAL ACCESS TO JUSTICE ACT Applicant Information Required § 625.11 Net worth exhibit... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  11. 47 CFR 1.1512 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Net worth exhibit. 1.1512 Section 1.1512... Applicants § 1.1512 Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the net worth of...

  12. 14 CFR 1262.202 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Net worth exhibit. 1262.202 Section 1262.202... PROCEEDINGS Information Required From Applicants § 1262.202 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant and any affiliates (as defiined in § 1262.104(f) when...

  13. 10 CFR 1023.311 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Net worth exhibit. 1023.311 Section 1023.311 Energy... Access to Justice Act Information Required from Applicants § 1023.311 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  14. 17 CFR 148.12 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Net worth exhibit. 148.12... Required from Applicants § 148.12 Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the...

  15. 17 CFR 148.12 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Net worth exhibit. 148.12... Required from Applicants § 148.12 Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the...

  16. 10 CFR 1023.311 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Net worth exhibit. 1023.311 Section 1023.311 Energy... Access to Justice Act Information Required from Applicants § 1023.311 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  17. 49 CFR 6.19 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Net worth exhibit. 6.19 Section 6.19... PROCEEDINGS Information Required from Applicants § 6.19 Net worth exhibit. (a) Each applicant except a... exhibit showing the net worth of the applicant and any affiliates (as defined in this part) when...

  18. 10 CFR 12.202 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Net worth exhibit. 12.202 Section 12.202 Energy NUCLEAR... Required From Applicants § 12.202 Net worth exhibit. (a) Each applicant, except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the...

  19. 47 CFR 1.1512 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Net worth exhibit. 1.1512 Section 1.1512... Applicants § 1.1512 Net worth exhibit. (a) Each applicant except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the net worth of...

  20. 10 CFR 12.202 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Net worth exhibit. 12.202 Section 12.202 Energy NUCLEAR... Required From Applicants § 12.202 Net worth exhibit. (a) Each applicant, except a qualified tax-exempt organization or cooperative association must provide with its application a detailed exhibit showing the...

  1. 14 CFR 1262.202 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Net worth exhibit. 1262.202 Section 1262... AGENCY PROCEEDINGS Information Required From Applicants § 1262.202 Net worth exhibit. (a) Each applicant... detailed exhibit showing the net worth of the applicant and any affiliates (as defiined in §...

  2. 39 CFR 960.10 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Net worth exhibit. 960.10 Section 960.10 Postal... JUSTICE ACT IN POSTAL SERVICE PROCEEDINGS Information Required From Applicants § 960.10 Net worth exhibit... with its application a detailed exhibit showing the net worth of the applicant and any affiliates...

  3. Online Cultural Heritage Exhibitions: A Survey of Strategic Issues

    ERIC Educational Resources Information Center

    Liew, Chern Li

    2006-01-01

    Purpose: This paper seeks to report findings from a study that looked at a range of strategic issues faced in the development, management and maintenance of online cultural heritage exhibitions. The study examined exhibitions from different types of cultural agencies and asked questions about whether, for instance, the exhibitions are part of the…

  4. Weight lifting can facilitate appreciative comprehension for museum exhibits

    PubMed Central

    Yamada, Yuki; Harada, Shinya; Choi, Wonje; Fujino, Rika; Tokunaga, Akinobu; Gao, YueYun; Miura, Kayo

    2014-01-01

    Appreciation of exhibits in a museum can be equated to a virtual experience of lives in the contexts originally surrounding the exhibits. Here we focus on the importance of weight information, and hence tested whether experiencing a weight during museum exhibit appreciation affects the beholders' satisfaction and recognition memory for the exhibits. An experiment was performed at a museum exhibiting skeletal preparations of animals. We used nine preparations and prepared four weight stimuli as weight cues in accordance with the actual weight of four of the preparations: Remaining five preparations was displayed without weight stimuli. In the cued condition, participants were asked to lift up the weight stimuli during their observation of the four exhibits. In the uncued condition, participants observed the exhibits without touching the weight stimuli. After observation of the exhibits, the participants responded to a questionnaire that measured their impressions of the exhibits and the museum, and performed a recognition test on the exhibits. Results showed that memory performance was better and viewing duration was longer with weight lifting instruction than without instruction. A factor analysis on the questionnaires revealed four factors (likeability, contentment, value, and quality). A path analysis showed indirect effects of viewing duration on memory performance and willingness-to-pay (WTP) for the museum appreciation through the impression factors. Our findings provide insight into a new interactive exhibition that enables long appreciation producing positive effects on visitors' impression, memory, and value estimation for exhibits. PMID:24782807

  5. [Review of the pharmaceutical exhibitions in the Meiji Era (Supplement)].

    PubMed

    Koyama, T

    1994-01-01

    The author described (Jpn. J. History Pharm. 16(1), 9-20 (1981) the Review of the Pharmaceutical Exhibitions in the Meiji era. But afterwards the author found there were omissions of three exhibitions. These are the Nagaoka, the Osaka, and the Akita Exhibitions. The Nagaoka Exhibition was organized by the Nagaoka Pharmacists Association in June, 1890. The Osaka Exhibition opened on Jan. 18, 1891 by Osaka Branch of the Pharmaceutical Society of Japan. The Akita Pharmaceutical Exhibition was held on Sept. 24-26, 1892, as the chief event of the opening ceremony of the Akita Drug-Trader Association, united pharmacists, druggists, and drug-manufacturers throughout Akita Prefecture. It is the most large-scaled of the three. The exhibits were 1,419, and the visitors were above 8,830. The planning originated with a young pharmacist Masayasu Hanyu.

  6. [Energy education exhibits for Insights El Paso Science Museum

    SciTech Connect

    Shubinski, R.

    1998-05-27

    The grant in question, DE-FG03-94ER75954, was awarded to Insights El Paso Science Museum to build key exhibits. These exhibits helped the Museum fulfill its mission to ``promote curiosity and stimulate interest by exploratory, entertaining, exciting, and participatory learning in a broad range of scientific disciplines to persons of all ages regionally and internationally.`` There are several current Board of Directors members who also were Board members during the grant period and who helped construct some of the exhibits. Through speaking with them and reviewing minutes of Board meetings during 1994, it has been determined that seven of the ten proposed exhibits were constructed, with an eighth exhibit constructed as an alternative. Photos of seven of the exhibits and preliminary sketches of some are attached. Following is a list of the constructed exhibits: Hot or Cold, Give and Take, Conduction, Convection, Sources of Energy, Wind Generator, Solar Tracker, and Perpetual Motion.

  7. Piper betle extracts exhibit antitumor activity by augmenting antioxidant potential.

    PubMed

    Alam, Badrul; Majumder, Rajib; Akter, Shahina; Lee, Sang-Han

    2015-02-01

    The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells into mice, extracts were administered at 25, 50 and 100 mg/kg body weight for nine consecutive days. The antitumor effects of the extracts were then assessed according to tumor volume, packed cell count, viable and non-viable tumor cell count, median survival time and increase in life span of EAC-bearing mice. Next, hematological profiles and serum biochemical parameters were calculated, and antioxidant properties were assessed by estimating lipid peroxidation, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels. MPBL and the ethylacetate fraction (EPBL) at a dose of 100 mg/kg induced a significant decrease in tumor volume, packed cell volume and viable cell count and increased the life span of the EAC-bearing mice (P<0.05). Hematological and serum biochemical profiles were restored to normal levels in the extract-treated mice compared with the EAC control mice. MPBL and EPBL treatment significantly decreased lipid peroxidation (P<0.05) and restored GSH, SOD and CAT levels towards normal compared with the EAC control. Taken together, the results of the present study demonstrated that Piper betle extracts exhibit significant antitumor activity, which may be attributed to the augmentation of endogenous antioxidant potential.

  8. Artificially engineered Heusler ferrimagnetic superlattice exhibiting perpendicular magnetic anisotropy

    NASA Astrophysics Data System (ADS)

    Ma, Q. L.; Zhang, X. M.; Miyazaki, T.; Mizukami, S.

    2015-01-01

    To extend density limits in magnetic recording industry, two separate strategies were developed to build the storage bit in last decade, introduction of perpendicular magnetic anisotropy (PMA) and adoption of ferrimagnetism/antiferromagnetism. Meanwhile, these properties significantly improve device performance, such as reducing spin-transfer torque energy consumption and decreasing signal-amplitude-loss. However, materials combining PMA and antiferromagnetism rather than transition-metal/rare-earth system were rarely developed. Here, we develop a new type of ferrimagnetic superlattice exhibiting PMA based on abundant Heusler alloy families. The superlattice is formed by [MnGa/Co2FeAl] unit with their magnetizations antiparallel aligned. The effective anisotropy (Kueff) over 6 Merg/cm3 is obtained, and the SL can be easily built on various substrates with flexible lattice constants. The coercive force, saturation magnetization and Kueff of SLs are highly controllable by varying the thickness of MnGa and Co2FeAl layers. The SLs will supply a new choice for magnetic recording and spintronics memory application such as magnetic random access memory.

  9. Artificially engineered Heusler ferrimagnetic superlattice exhibiting perpendicular magnetic anisotropy

    PubMed Central

    Ma, Q. L.; Zhang, X. M.; Miyazaki, T.; Mizukami, S.

    2015-01-01

    To extend density limits in magnetic recording industry, two separate strategies were developed to build the storage bit in last decade, introduction of perpendicular magnetic anisotropy (PMA) and adoption of ferrimagnetism/antiferromagnetism. Meanwhile, these properties significantly improve device performance, such as reducing spin-transfer torque energy consumption and decreasing signal-amplitude-loss. However, materials combining PMA and antiferromagnetism rather than transition-metal/rare-earth system were rarely developed. Here, we develop a new type of ferrimagnetic superlattice exhibiting PMA based on abundant Heusler alloy families. The superlattice is formed by [MnGa/Co2FeAl] unit with their magnetizations antiparallel aligned. The effective anisotropy (Kueff) over 6 Merg/cm3 is obtained, and the SL can be easily built on various substrates with flexible lattice constants. The coercive force, saturation magnetization and Kueff of SLs are highly controllable by varying the thickness of MnGa and Co2FeAl layers. The SLs will supply a new choice for magnetic recording and spintronics memory application such as magnetic random access memory. PMID:25597496

  10. Artificially engineered Heusler ferrimagnetic superlattice exhibiting perpendicular magnetic anisotropy.

    PubMed

    Ma, Q L; Zhang, X M; Miyazaki, T; Mizukami, S

    2015-01-19

    To extend density limits in magnetic recording industry, two separate strategies were developed to build the storage bit in last decade, introduction of perpendicular magnetic anisotropy (PMA) and adoption of ferrimagnetism/antiferromagnetism. Meanwhile, these properties significantly improve device performance, such as reducing spin-transfer torque energy consumption and decreasing signal-amplitude-loss. However, materials combining PMA and antiferromagnetism rather than transition-metal/rare-earth system were rarely developed. Here, we develop a new type of ferrimagnetic superlattice exhibiting PMA based on abundant Heusler alloy families. The superlattice is formed by [MnGa/Co2FeAl] unit with their magnetizations antiparallel aligned. The effective anisotropy (K(u)(eff)) over 6 Merg/cm(3) is obtained, and the SL can be easily built on various substrates with flexible lattice constants. The coercive force, saturation magnetization and K(u)(eff) of SLs are highly controllable by varying the thickness of MnGa and Co2FeAl layers. The SLs will supply a new choice for magnetic recording and spintronics memory application such as magnetic random access memory.

  11. Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis.

    PubMed

    Loos, Julia A; Dávila, Valeria A; Rodrígues, Christian R; Petrigh, Romina; Zoppi, Jorge A; Crocenzi, Fernando A; Cumino, Andrea C

    2017-02-01

    Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy of Met against the larval stage of Echinococcus granulosus. Metformin showed significant dose- and time-dependent killing effects on in vitro cultured protoscoleces and metacestodes. Notably, the combination of Met together with the minimum effective concentration of ABZSO had a synergistic effect after days 3 and 12 on metacestodes and protoscoleces, respectively. Oral administration of Met (50 mg/kg/day) in E. granulosus-infected mice was highly effective in reducing the weight and number of parasite cysts, yet its combination with the lowest recommended dose of ABZ (5 mg/kg/day) was even more effective. Coincidentally, intracystic Met accumulation was higher in animals treated with both drugs compared to those administered Met alone. Furthermore, the safe plant-derived drug Met exhibited remarkable chemopreventive properties against secondary hydatidosis in mice. In conclusion, based on our experimental data, Met emerges as a promising anti-echinococcal drug as it has proven to efficiently inhibit the development and growth of the E. granulosus larval stage and its combination with ABZ may improve the current anti-parasitic therapy.

  12. Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis

    PubMed Central

    Loos, Julia A.; Dávila, Valeria A.; Rodrígues, Christian R.; Petrigh, Romina; Zoppi, Jorge A.; Crocenzi, Fernando A.; Cumino, Andrea C.

    2017-01-01

    Metformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy of Met against the larval stage of Echinococcus granulosus. Metformin showed significant dose- and time-dependent killing effects on in vitro cultured protoscoleces and metacestodes. Notably, the combination of Met together with the minimum effective concentration of ABZSO had a synergistic effect after days 3 and 12 on metacestodes and protoscoleces, respectively. Oral administration of Met (50 mg/kg/day) in E. granulosus-infected mice was highly effective in reducing the weight and number of parasite cysts, yet its combination with the lowest recommended dose of ABZ (5 mg/kg/day) was even more effective. Coincidentally, intracystic Met accumulation was higher in animals treated with both drugs compared to those administered Met alone. Furthermore, the safe plant-derived drug Met exhibited remarkable chemopreventive properties against secondary hydatidosis in mice. In conclusion, based on our experimental data, Met emerges as a promising anti-echinococcal drug as it has proven to efficiently inhibit the development and growth of the E. granulosus larval stage and its combination with ABZ may improve the current anti-parasitic therapy. PMID:28182659

  13. Once a physicist: Zhengrong Shi

    NASA Astrophysics Data System (ADS)

    Shi, Zhengrong

    2009-02-01

    Why did you choose to study physics? I was born on an island called Yangzhong on the Yangtze River in Jiangsu province, China. Though mainly agricultural, Yangzhong was blessed with a good school system and I dedicated myself to my studies. I followed my instincts and interests in science and built a strong foundation in physics. My family always encouraged me to pursue my studies, so I went on to obtain a Bachelor°s degree in optical science from Chang Chun University of Science and Technology in 1983 and a Master°s degree in laser physics from the Shanghai Institute of Optics and Fine Mechanics in 1986.

  14. Comparison of stem morphology and anatomy of two alfalfa clonal lines exhibiting divergent cell wall composition

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In previous research, two alfalfa clonal lines (252, 1283) were identified that exhibited environmentally stable differences in stem cell walls. Compared to stems of 1283, stems of 252 have a higher cell wall concentration and greater amounts of lignin and cellulose but reduced levels of pectic suga...

  15. Evolutionary Dynamics of Influenza A Viruses in US Exhibition Swine.

    PubMed

    Nelson, Martha I; Wentworth, David E; Das, Suman R; Sreevatsan, Srinand; Killian, Mary L; Nolting, Jacqueline M; Slemons, Richard D; Bowman, Andrew S

    2016-01-15

    The role of exhibition swine in influenza A virus transmission was recently demonstrated by >300 infections with influenza A(H3N2) variant viruses among individuals who attended agricultural fairs. Through active influenza A virus surveillance in US exhibition swine and whole-genome sequencing of 380 isolates, we demonstrate that exhibition swine are actively involved in the evolution of influenza A viruses, including zoonotic strains. First, frequent introduction of influenza A viruses from commercial swine populations provides new genetic diversity in exhibition pigs each year locally. Second, genomic reassortment between viruses cocirculating in exhibition swine increases viral diversity. Third, viral migration between exhibition swine in neighboring states demonstrates that movements of exhibition pigs contributes to the spread of genetic diversity. The unexpected frequency of viral exchange between commercial and exhibition swine raises questions about the understudied interface between these populations. Overall, the complexity of viral evolution in exhibition swine indicates that novel viruses are likely to continually reemerge, presenting threats to humans.

  16. 18. INTERIOR OF CIVIL RIGHTS INSTITUTE, MILESTONE GALLERY EXHIBITION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. INTERIOR OF CIVIL RIGHTS INSTITUTE, MILESTONE GALLERY EXHIBITION OF THE SIXTEENTH STREET CHURCH, LOOKING NORTHWEST - Sixteenth Street Baptist Church, 1530 Sixth Avenue North, Birmingham, Jefferson County, AL

  17. Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype.

    PubMed

    Koippallil Gopalakrishnan Nair, Aghila Rani; Pandit, Hrishikesh; Warty, Neeta; Madan, Taruna

    2015-04-01

    Endometriosis is a significant debilitating gynecological problem affecting women of the reproductive age group and post-menopause. Recent reports suggest a role for endometriotic mesenchymal stem cells (ectopic MSCs) in the pathogenesis of endometriosis. To investigate the plausible mechanisms leading to the pathogenic behavior of ectopic MSCs, we compared the immunomodulatory properties of eutopic (healthy) and ectopic MSCs. We analyzed MSC phenotypes, differentiation potential, differential gene expression for an array of pattern recognition receptors (PRRs) and pro-inflammatory cytokine release along with markers of migration and angiogenesis among eutopic and ectopic MSCs. Further, alterations in immunosuppressive functions of eutopic and ectopic MSCs were examined by co-culturing them with mitogen-activated allogeneic PBMCs. Transcripts of PRRs such as all Toll-like receptors (TLR1-10), except TLR8, collectins (CL-L1, CL-P1 and CL-K1), NOD-1 and NOD-2 receptors and secreted pro-inflammatory cytokines like IL-6, IFN-γ, vascular endothelial growth factor (VEGF), epidermal growth factor and MCP-1 were significantly up-regulated in ectopic MSCs. The anti-inflammatory cytokine transforming growth factor-β showed significant down-regulation, while IL-10 showed a significant increase in ectopic MSCs. Further, ectopic MSCs showed up-regulated expression for markers of migration and angiogenesis such as matrix metalloproteinase-2 (MMP-2), MMP-3 and MMP-9 and VEGF, respectively. We report here that proliferation of PBMCs was less inhibited upon co-culture with ectopic MSCs compared with eutopic MSCs. The findings suggest that ectopic MSCs with increased levels of TLRs, collectins, pro-inflammatory cytokines and markers of migration and angiogenesis exhibit a distinct immune phenotype compared to eutopic MSCs. This distinct phenotype may be responsible for the reduced immunosuppressive property of ectopic MSCs and may be associated with the pathogenesis of

  18. Arabidopsis Mutant bik1 Exhibits Strong Resistance to Plasmodiophora brassicae

    PubMed Central

    Chen, Tao; Bi, Kai; He, Zhangchao; Gao, Zhixiao; Zhao, Ying; Fu, Yanping; Cheng, Jiasen; Xie, Jiatao; Jiang, Daohong

    2016-01-01

    Botrytis-induced kinase1 (BIK1), a receptor-like cytoplasmic kinase, plays an important role in resistance against pathogens and insects in Arabidopsis thaliana. However, it remains unknown whether BIK1 functions against Plasmodiophora brassicae, an obligate biotrophic protist that attacks cruciferous plants and induces gall formation on roots. Here, we investigated the potential roles of receptors FLS2, BAK1, and BIK1 in the infection of P. brassicae cruciferous plants. Wild-type plants, fls2, and bak1 mutants showed typical symptom on roots, and the galls were filled with large quantities of resting spores, while bik1 mutant plants exhibited strong resistance to P. brassicae. Compared with that of the wild-type plants, the root hair and cortical infection rate of bik1 mutant were significantly reduced by about 40–50%. A considerable portion of bik1 roots failed to form typical galls. Even if some small galls were formed, they were filled with multinucleate secondary plasmodia. The bik1 plants accumulated less reactive oxygen species (ROS) at infected roots than other mutants and wild-type plants. Exogenous salicylic acid (SA) treatment alleviated the clubroot symptoms in wild-type plants, and the expression of the SA signaling marker gene PR1 was significantly increased in bik1. Both sid2 (salicylic acid induction-deficient 2) and npr1-1 [non-expresser of PR genes that regulate systemic acquired resistance (SAR)] mutants showed increased susceptibility to P. brassicae compared with wild-type plants. These results suggest that the resistance of bik1 to P. brassicae is possibly mediated by SA inducible mechanisms. PMID:27679580

  19. 7 CFR Exhibit A to Subpart A of... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false A Exhibit A to Subpart A of Part 1902 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... SUPERVISED BANK ACCOUNTS Supervised Bank Accounts of Loan, Grant, and Other Funds Exhibit A to Subpart A...

  20. 7 CFR Exhibit A to Subpart A of... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true A Exhibit A to Subpart A of Part 1902 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... SUPERVISED BANK ACCOUNTS Supervised Bank Accounts of Loan, Grant, and Other Funds Exhibit A to Subpart A...

  1. 7 CFR Exhibits A-F to Subpart A... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 14 2013-01-01 2013-01-01 false A Exhibits A-F to Subpart A of Part 1955 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Real and Chattel Property Exhibits A-F to Subpart A of Part 1955...

  2. 7 CFR Exhibits A-F to Subpart A... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 14 2012-01-01 2012-01-01 false A Exhibits A-F to Subpart A of Part 1955 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Real and Chattel Property Exhibits A-F to Subpart A of Part 1955...

  3. 7 CFR Exhibit A to Subpart A of... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false A Exhibit A to Subpart A of Part 1902 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... SUPERVISED BANK ACCOUNTS Supervised Bank Accounts of Loan, Grant, and Other Funds Exhibit A to Subpart A...

  4. 7 CFR Exhibits A-F to Subpart A... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 14 2014-01-01 2014-01-01 false A Exhibits A-F to Subpart A of Part 1955 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Real and Chattel Property Exhibits A-F to Subpart A of Part 1955...

  5. 7 CFR Exhibit A to Subpart A of... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false A Exhibit A to Subpart A of Part 1902 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... SUPERVISED BANK ACCOUNTS Supervised Bank Accounts of Loan, Grant, and Other Funds Exhibit A to Subpart A...

  6. 7 CFR Exhibits A-F to Subpart A... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true A Exhibits A-F to Subpart A of Part 1955 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Real and Chattel Property Exhibits A-F to Subpart A of Part 1955...

  7. 7 CFR Exhibit A to Subpart A of... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false A Exhibit A to Subpart A of Part 1902 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... SUPERVISED BANK ACCOUNTS Supervised Bank Accounts of Loan, Grant, and Other Funds Exhibit A to Subpart A...

  8. 7 CFR Exhibits A-F to Subpart A... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false A Exhibits A-F to Subpart A of Part 1955 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Real and Chattel Property Exhibits A-F to Subpart A of Part 1955...

  9. Data Collection Methods for Evaluating Museum Programs and Exhibitions

    ERIC Educational Resources Information Center

    Nelson, Amy Crack; Cohn, Sarah

    2015-01-01

    Museums often evaluate various aspects of their audiences' experiences, be it what they learn from a program or how they react to an exhibition. Each museum program or exhibition has its own set of goals, which can drive what an evaluator studies and how an evaluation evolves. When designing an evaluation, data collection methods are purposefully…

  10. Exhibitions: Connecting Classroom Assessment with Culminating Demonstrations of Mastery

    ERIC Educational Resources Information Center

    Davidson, Jill

    2009-01-01

    Exhibitions are public demonstrations of mastery that occur at culminating moments, such as at the conclusion of a unit of study, the transition from one level of schooling to the next, and graduation. Exhibitions require students to speak publicly, use evidence, present engaging visual displays, and otherwise demonstrate mastery to educators,…

  11. 7 CFR Exhibit C to Subpart N of... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true C Exhibit C to Subpart N of Part 1944 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants Exhibit C to Subpart N of Part 1944...

  12. 7 CFR Exhibit C to Subpart N of... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true C Exhibit C to Subpart N of Part 1944 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants Exhibit C to Subpart N of Part 1944...

  13. 7 CFR Exhibit C to Subpart N of... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 13 2012-01-01 2012-01-01 false C Exhibit C to Subpart N of Part 1944 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants Exhibit C to Subpart N of Part 1944...

  14. 7 CFR Exhibit C to Subpart N of... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false C Exhibit C to Subpart N of Part 1944 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants Exhibit C to Subpart N of Part 1944...

  15. 7 CFR Exhibit G to Subpart A of... - Performance Bond

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Performance Bond G Exhibit G to Subpart A of Part.... 1924, Subpt. A, Exh. G Exhibit G to Subpart A of Part 1924—Performance Bond KNOW ALL PERSONS BY THESE... and faithful performance of the CONTRACT as so amended. The term “Amendment”, wherever used in...

  16. 7 CFR Exhibit A to Subpart L of... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true A Exhibit A to Subpart L of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Exhibit A to Subpart L of Part 1940...

  17. 7 CFR Exhibit A to Subpart L of... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 13 2012-01-01 2012-01-01 false A Exhibit A to Subpart L of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Exhibit A to Subpart L of Part 1940...

  18. 7 CFR Exhibit A to Subpart L of... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true A Exhibit A to Subpart L of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Exhibit A to Subpart L of Part 1940...

  19. 7 CFR Exhibit A to Subpart L of... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true A Exhibit A to Subpart L of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Exhibit A to Subpart L of Part 1940...

  20. 7 CFR Exhibit A to Subpart L of... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 13 2013-01-01 2013-01-01 false A Exhibit A to Subpart L of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... Exhibit A to Subpart L of Part 1940...

  1. Modelling the Future: Exhibitions and the Materiality of Education

    ERIC Educational Resources Information Center

    Lawn, Martin, Ed.

    2009-01-01

    The role of World Exhibitions in the 19th and early 20th centuries was to confirm a relation between the nation state and modernity. As a display about industries, inventions and identities, the Exhibition, in a sense, put entire nations into an elevated, viewable space. It is a significant element in modernity as comparisons can be made, progress…

  2. 76 FR 61472 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Game of Kings: Medieval Ivory... Kings: Medieval Ivory Chessmen from the Isle of Lewis,'' imported from abroad for temporary exhibition..., Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: September 27, 2011. J. Adam Ereli,...

  3. Champions of American Sport--A Major Exhibition.

    ERIC Educational Resources Information Center

    Sorani, Bob

    1981-01-01

    An exhibit of 100 photographs, portraits, and sculptures, entitled "Champions of American Sport", is the first major art exhibit ever devoted to outstanding American sports personalities and to the aesthetic qualities of sport and human movement. The Smithsonian Institution is sponsoring the traveling collection, which includes works from the…

  4. Outreach to Science Faculty and Students through Research Exhibitions

    ERIC Educational Resources Information Center

    Chan, Tina; Hebblethwaite, Chris

    2014-01-01

    Penfield Library at the State University of New York at Oswego (SUNY Oswego) has a gallery exhibit space near the front entrance that is used to showcase student-faculty research and art class projects. This article features the library's outreach efforts to science faculty and students through research exhibitions. The library held an exhibition…

  5. Designing Art Exhibitions in an Educational Virtual World

    ERIC Educational Resources Information Center

    Julian, June; Crooks, Julian

    2011-01-01

    Demonstrating the multiple features of the Cerulean Gallery in Second Life, this research report showcases several exemplar exhibits created by students, artists, and museums. Located in The Educational Media Center, a Second Life teaching and social space, the Cerulean Gallery exhibits functioned as case studies that tested its effectiveness as…

  6. A Commemorative History of the George Rogers Clark Bicentennial Exhibit.

    ERIC Educational Resources Information Center

    Indiana State Museum Society, Inc., Indianapolis.

    This pamphlet provides an illustrated narrative history of the George Rogers Clark Bicentennial Exhibit at the Indiana State Museum. George Rogers Clark was a frontier hero of the American Revolution who explored and conquered territory in Kentucky, Ohio, and Illinois. The multimedia exhibit is open to the public from February 25, 1976 through…

  7. 14 CFR 14.11 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Net worth exhibit. 14.11 Section 14.11... IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants § 14.11 Net worth... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  8. 28 CFR 24.202 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Net worth exhibit. 24.202 Section 24.202... DEPARTMENT OF JUSTICE ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 24.202 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  9. 47 CFR 1.1512 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Net worth exhibit. 1.1512 Section 1.1512... Access to Justice Act (EAJA) in Agency Proceedings Information Required from Applicants § 1.1512 Net... must provide with its application a detailed exhibit showing the net worth of the applicant and...

  10. 29 CFR 16.202 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Net worth exhibit. 16.202 Section 16.202 Labor Office of the Secretary of Labor EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 16.202 Net... must provide with its application a detailed exhibit showing the net worth of the applicant and...

  11. 28 CFR 24.202 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Net worth exhibit. 24.202 Section 24.202... DEPARTMENT OF JUSTICE ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 24.202 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  12. 24 CFR 14.205 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Net worth exhibit. 14.205 Section... Required From Applicants § 14.205 Net worth exhibit. (a) Each applicant except a qualified tax-exempt... the net worth of the applicant and any affiliates (as defined in § 14.120(f) of this part) when...

  13. 40 CFR 17.12 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Net worth exhibit. 17.12 Section 17.12... JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 17.12 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  14. 22 CFR 134.12 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Net worth exhibit. 134.12 Section 134.12... Information Required From Applicants § 134.12 Net worth exhibit. (a) Each applicant except a qualifed tax... showing the net worth of the applicant and any affiliates (as defined in § 960.4(f)) when the...

  15. 24 CFR 14.205 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Net worth exhibit. 14.205 Section... Required From Applicants § 14.205 Net worth exhibit. (a) Each applicant except a qualified tax-exempt... the net worth of the applicant and any affiliates (as defined in § 14.120(f) of this part) when...

  16. 28 CFR 24.202 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Net worth exhibit. 24.202 Section 24.202... DEPARTMENT OF JUSTICE ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 24.202 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  17. 22 CFR 134.12 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Net worth exhibit. 134.12 Section 134.12... Information Required From Applicants § 134.12 Net worth exhibit. (a) Each applicant except a qualifed tax... showing the net worth of the applicant and any affiliates (as defined in § 960.4(f)) when the...

  18. 28 CFR 24.202 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Net worth exhibit. 24.202 Section 24.202... DEPARTMENT OF JUSTICE ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 24.202 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  19. 12 CFR 1203.11 - Confidentiality of net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Confidentiality of net worth exhibit. 1203.11... INFORMATION ACT Information Required From Applicants § 1203.11 Confidentiality of net worth exhibit. Unless otherwise ordered by the Director, or required by law, the statement of net worth will be for...

  20. 14 CFR 14.11 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Net worth exhibit. 14.11 Section 14.11... IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants § 14.11 Net worth... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  1. 28 CFR 24.202 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Net worth exhibit. 24.202 Section 24.202... DEPARTMENT OF JUSTICE ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 24.202 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  2. 29 CFR 16.202 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Net worth exhibit. 16.202 Section 16.202 Labor Office of the Secretary of Labor EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 16.202 Net... must provide with its application a detailed exhibit showing the net worth of the applicant and...

  3. 12 CFR 1203.11 - Confidentiality of net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Confidentiality of net worth exhibit. 1203.11... TO JUSTICE ACT Information Required From Applicants § 1203.11 Confidentiality of net worth exhibit. Unless otherwise ordered by the Director, or required by law, the statement of net worth will be for...

  4. 24 CFR 14.205 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Net worth exhibit. 14.205 Section... Required From Applicants § 14.205 Net worth exhibit. (a) Each applicant except a qualified tax-exempt... the net worth of the applicant and any affiliates (as defined in § 14.120(f) of this part) when...

  5. 22 CFR 134.12 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Net worth exhibit. 134.12 Section 134.12... Information Required From Applicants § 134.12 Net worth exhibit. (a) Each applicant except a qualifed tax... showing the net worth of the applicant and any affiliates (as defined in § 960.4(f)) when the...

  6. 40 CFR 17.12 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Net worth exhibit. 17.12 Section 17.12... JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 17.12 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  7. 29 CFR 16.202 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Net worth exhibit. 16.202 Section 16.202 Labor Office of the Secretary of Labor EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 16.202 Net worth... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  8. 29 CFR 16.202 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Net worth exhibit. 16.202 Section 16.202 Labor Office of the Secretary of Labor EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 16.202 Net... must provide with its application a detailed exhibit showing the net worth of the applicant and...

  9. 22 CFR 134.12 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Net worth exhibit. 134.12 Section 134.12... Information Required From Applicants § 134.12 Net worth exhibit. (a) Each applicant except a qualifed tax... showing the net worth of the applicant and any affiliates (as defined in § 960.4(f)) when the...

  10. 47 CFR 1.1512 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Net worth exhibit. 1.1512 Section 1.1512... Access to Justice Act (EAJA) in Agency Proceedings Information Required from Applicants § 1.1512 Net... must provide with its application a detailed exhibit showing the net worth of the applicant and...

  11. 14 CFR 14.11 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Net worth exhibit. 14.11 Section 14.11... IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants § 14.11 Net worth... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  12. 29 CFR 16.202 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Net worth exhibit. 16.202 Section 16.202 Labor Office of the Secretary of Labor EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 16.202 Net worth... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  13. 17 CFR 148.12 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Net worth exhibit. 148.12... Information Required from Applicants § 148.12 Net worth exhibit. (a) Each applicant except a qualified tax... showing the net worth of the applicant and any affiliates (as defined in § 148.4(f) of this part) when...

  14. 40 CFR 17.12 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Net worth exhibit. 17.12 Section 17.12... JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 17.12 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  15. 24 CFR 14.205 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Net worth exhibit. 14.205 Section... Required From Applicants § 14.205 Net worth exhibit. (a) Each applicant except a qualified tax-exempt... the net worth of the applicant and any affiliates (as defined in § 14.120(f) of this part) when...

  16. 40 CFR 17.12 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Net worth exhibit. 17.12 Section 17.12... JUSTICE ACT IN EPA ADMINISTRATIVE PROCEEDINGS Information Required From Applicants § 17.12 Net worth... submit with its application a detailed exhibit showing its net worth at the time the proceeding...

  17. 14 CFR 14.11 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Net worth exhibit. 14.11 Section 14.11... IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants § 14.11 Net worth... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  18. 12 CFR 1203.11 - Confidentiality of net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Confidentiality of net worth exhibit. 1203.11... TO JUSTICE ACT Information Required From Applicants § 1203.11 Confidentiality of net worth exhibit. Unless otherwise ordered by the Director, or required by law, the statement of net worth will be for...

  19. 24 CFR 14.205 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Net worth exhibit. 14.205 Section... Required From Applicants § 14.205 Net worth exhibit. (a) Each applicant except a qualified tax-exempt... the net worth of the applicant and any affiliates (as defined in § 14.120(f) of this part) when...

  20. 14 CFR 14.11 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Net worth exhibit. 14.11 Section 14.11... IMPLEMENTING THE EQUAL ACCESS TO JUSTICE ACT OF 1980 Information Required From Applicants § 14.11 Net worth... provide with its application a detailed exhibit showing the net worth of the applicant and any...

  1. Using Museum Exhibits: An Innovation in Experiential Learning

    ERIC Educational Resources Information Center

    Das, Satarupa

    2015-01-01

    Museum exhibits can be a tool in experiential learning. While instructors have documented various methods of experiential learning, they have not sufficiently explored such learning from museum exhibits. Museum researchers, however, have long found a satisfying cognitive component to museum visits. This paper narrates the author's design to…

  2. 18 CFR 385.508 - Exhibits (Rule 508).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Exhibits (Rule 508). 385.508 Section 385.508 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY PROCEDURAL RULES RULES OF PRACTICE AND PROCEDURE Hearings § 385.508 Exhibits (Rule...

  3. 18 CFR 385.508 - Exhibits (Rule 508).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Exhibits (Rule 508). 385.508 Section 385.508 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY PROCEDURAL RULES RULES OF PRACTICE AND PROCEDURE Hearings § 385.508 Exhibits (Rule...

  4. 18 CFR 385.508 - Exhibits (Rule 508).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Exhibits (Rule 508). 385.508 Section 385.508 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY PROCEDURAL RULES RULES OF PRACTICE AND PROCEDURE Hearings § 385.508 Exhibits (Rule...

  5. 7 CFR Exhibit G to Subpart G of... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true G Exhibit G to Subpart G of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) GENERAL Environmental Program Exhibit G to Subpart G of Part 1940...

  6. 7 CFR Exhibit G to Subpart A of... - Performance Bond

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Performance Bond G Exhibit G to Subpart A of Part 1924 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL.... 1924, Subpt. A, Exh. G Exhibit G to Subpart A of Part 1924—Performance Bond KNOW ALL PERSONS BY...

  7. 18 CFR 385.508 - Exhibits (Rule 508).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Exhibits (Rule 508). 385.508 Section 385.508 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY PROCEDURAL RULES RULES OF PRACTICE AND PROCEDURE Hearings § 385.508 Exhibits (Rule...

  8. A Critical Appraisal of State Level Science Exhibition

    ERIC Educational Resources Information Center

    Nath, Baiju K.

    2007-01-01

    Science exhibitions are really great opportunities to students as well as teachers to disseminate knowledge that they have, and to experience a variety of new inventions and innovations that also need wide dissemination. The great significance of exhibition is that it fosters acquisition of different process skills leading to the development of…

  9. 14 CFR 77.59 - Subpoenas of witnesses and exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Subpoenas of witnesses and exhibits. 77.59 Section 77.59 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... for any witness or exhibit that he determines may be material and relevant to the issues of...

  10. 7 CFR Exhibit F to Subpart A of... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true F Exhibit F to Subpart A of Part 1962 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) PERSONAL PROPERTY Servicing and Liquidation of Chattel Security Exhibit F to Subpart...

  11. 7 CFR Exhibit F to Subpart A of... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false F Exhibit F to Subpart A of Part 1962 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) PERSONAL PROPERTY Servicing and Liquidation of Chattel Security Exhibit F to Subpart...

  12. 7 CFR Exhibit F to Subpart A of... - Payment Bond

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Payment Bond F Exhibit F to Subpart A of Part 1924 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS.... A, Exh. F Exhibit F to Subpart A of Part 1924—Payment Bond KNOW ALL PERSONS BY THESE PRESENTS:...

  13. 7 CFR Exhibit F to Subpart A of... - Payment Bond

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Payment Bond F Exhibit F to Subpart A of Part 1924 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS.... A, Exh. F Exhibit F to Subpart A of Part 1924—Payment Bond KNOW ALL PERSONS BY THESE PRESENTS:...

  14. Cooperative Exhibition: A New Concept for the Apparel Design Teacher.

    ERIC Educational Resources Information Center

    Furer, Gloria

    1982-01-01

    Explains how an apparel and textile exhibition can benefit the institution that underwrites the project, the department that sponsors it, the community, and the apparel design teacher (through the chance for professional recognition). Methods for planning such an exhibition are given. (CT)

  15. 7 CFR Exhibit C to Subpart N of... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 13 2011-01-01 2009-01-01 true C Exhibit C to Subpart N of Part 1944 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants Exhibit C to Subpart N of Part 1944...

  16. 7 CFR Exhibit A to Subpart B of... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false A Exhibit A to Subpart B of Part 1900 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... GENERAL Adverse Decisions and Administrative Appeals Exhibit A to Subpart B of Part 1900...

  17. 22 CFR Exhibit B to Part 204 - Assignment

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Assignment B Exhibit B to Part 204 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT HOUSING GUARANTY STANDARD TERMS AND CONDITIONS Pt. 204, Exh. B Exhibit B to Part 204—Assignment The undersigned, being the registered owner of a Note in...

  18. 75 FR 3862 - Photography in Public Exhibit Space

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ... From the Federal Register Online via the Government Publishing Office NATIONAL ARCHIVES AND RECORDS ADMINISTRATION 36 CFR Part 1280 RIN 3095-AB60 Photography in Public Exhibit Space AGENCY: National... 2003, NARA completed a two year renovation of the Rotunda and constructed additional exhibit space...

  19. Reducing health inequalities for older LGBTQ+ people.

    PubMed

    Thomas, Ben

    2016-10-26

    The recent LGBTQ+ history exhibition Speak Out London, Diversity City presented a fantastic collection of stories, documents and photographs from LGBTQ+ Londoners. It also provided a reminder of how far we have come in reducing stigma, prejudice and discrimination.

  20. First major museum exhibit on the science of AIDS.

    PubMed

    Nary, G

    1995-05-01

    The Chicago Museum of Science and Industry recently opened its 4,000-square-foot permanent exhibit on the science of AIDS. The exhibit is designed to educate visitors about immunology and virology by presenting AIDS as an example of an immune system breakdown and showing advances made in research and prevention of diseases caused by viruses. The exhibit also seeks to engage preteens with compelling graphics and interactive displays in the hope of motivating them to pursue careers in science. One exhibit, called Frontline, allows visitors to question several physicians and researchers specializing in HIV/AIDS through a touch-screen video program. The exhibit allows these professionals to reveal their commitment and explain their views on the future of the pandemic.

  1. Statistical properties of chaotic dynamical systems which exhibit strange attractors

    SciTech Connect

    Jensen, R.V.; Oberman, C.R.

    1981-07-01

    A path integral method is developed for the calculation of the statistical properties of turbulent dynamical systems. The method is applicable to conservative systems which exhibit a transition to stochasticity as well as dissipative systems which exhibit strange attractors. A specific dissipative mapping is considered in detail which models the dynamics of a Brownian particle in a wave field with a broad frequency spectrum. Results are presented for the low order statistical moments for three turbulent regimes which exhibit strange attractors corresponding to strong, intermediate, and weak collisional damping.

  2. Unimode metamaterials exhibiting negative linear compressibility and negative thermal expansion

    NASA Astrophysics Data System (ADS)

    Dudek, Krzysztof K.; Attard, Daphne; Caruana-Gauci, Roberto; Wojciechowski, Krzysztof W.; Grima, Joseph N.

    2016-02-01

    Unimode metamaterials made from rotating rigid triangles are analysed mathematically for their mechanical and thermal expansion properties. It is shown that these unimode systems exhibit positive Poisson’s ratios irrespective of size, shape and angle of aperture, with the Poisson’s ratio exhibiting giant values for certain conformations. When the Poisson’s ratio in one loading direction is larger than +1, the systems were found to exhibit the anomalous property of negative linear compressibility along this direction, that is, the systems expand in this direction when hydrostatically compressed. Also discussed are the thermal expansion properties of these systems under the assumption that the units exhibit increased rotational agitation once subjected to an increase in temperature. The effect of the geometric parameters on the aforementioned thermo-mechanical properties of the system, are discussed, with the aim of identifying negative behaviour.

  3. 2016 National Training Conference Exhibit Booths and Poster Displays

    EPA Pesticide Factsheets

    Exhibit Booths and Poster Displays for the 2016 National Training Conference on the Toxics Release Inventory (TRI) and Environmental Conditions in Communities. Identifies presentation topics and speakers for October 19 and 20.

  4. Science, providence, and progress at the Great Exhibition.

    PubMed

    Cantor, Geoffrey

    2012-09-01

    The Great Exhibition of 1851 is generally interpreted as a thoroughly secular event that celebrated progress in science, technology, and industry. In contrast to this perception, however, the exhibition was viewed by many contemporaries as a religious event of considerable importance. Although some religious commentators were highly critical of the exhibition and condemned the display of artifacts in the Crystal Palace as giving succor to materialism, others incorporated science and technology into their religious frameworks. Drawing on sermons, tracts, and the religious periodical press, this essay pays close attention to the ways in which science and technology were endowed with providentialist significance and particularly examines the notion of human progress used by a number of Christian writers, especially Congregationalists, who set scientific and technological progress within a teleological religious perspective. This discussion sheds fresh light not only on the Great Exhibition itself but also on the deployment of natural theology in mid-nineteenth-century Britain.

  5. 75 FR 6079 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Compass and Rule: Architecture as...: Architecture as Mathematical Practice in England, 1500-1750,'' imported from abroad for temporary...

  6. EPAs Educational Exhibit Honored at Philadelphia Flower Show

    EPA Pesticide Factsheets

    PHILADELPHIA (March 8, 2016) - The U.S. Environmental Protection Agency's exhibit at the 2016 Philadelphia Flower Show was recognized with three prestigious awards. The awards include a Gold Medal Award by the Pennsylvania Horticultural Society for

  7. 17. INTERIOR VIEW OF BASEMENT EXHIBITION OF EVENTS OF CIVIL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. INTERIOR VIEW OF BASEMENT EXHIBITION OF EVENTS OF CIVIL RIGHTS MOVEMENT AND THE 1963 BOMBING OF THE CHURCH, LOOKING SOUTH - Sixteenth Street Baptist Church, 1530 Sixth Avenue North, Birmingham, Jefferson County, AL

  8. 48 CFR 6101.17 - Exhibits [Rule 17].

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of the hearing in order, for example, to eliminate the introduction of additional exhibits at the hearing. (2) If a party elects to proceed on the record without a hearing pursuant to 6101.19 (Rule...

  9. Assessment of Oral Reading Which Exhibits Dialect and Language Differences.

    ERIC Educational Resources Information Center

    Lamberg, Walter J.

    1979-01-01

    Describes specific training, using taped readings, designed to prepare teachers to accurately assess the oral reading of students who exhibit dialect or second language influences in their speech. (MKM)

  10. Bringing Planetary Science to the Public through Traveling Exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, P. B.

    2001-11-01

    The Space Science Institute (SSI) of Boulder, Colorado has recently developed two museum exhibits called the Space Weather Center and MarsQuest. It is currently planning to develop another exhibit called Gas Giants. These exhibitions provide research scientists the opportunity to engage in a number of activities that are vital to the success of these major outreach programs. The Space Weather Center was developed in partnership with various research missions at NASA's Goddard Space Flight Center. The focus of the presentation will be on MarsQuest and Gas Giants. MarsQuest is a 5000 square-foot, 3M, traveling exhibition that is now touring the country. The exhibit's 3-year tour will enable millions of Americans to share in the excitement of the scientific exploration of Mars and learn more about their own planet in the process. The associated planetarium show and education program will also be described, with particular emphasis on workshops to orient museum staff (e.g. museum educators and docents) and workshops for master educators near host museums and science centers. The workshops make innovative connections between the exhibitions interactive experiences and lesson plans aligned with the National Science Education Standards. These exhibit programs are good models for actively involving scientists and their discoveries to help improve informal science education in the museum community and for forging a stronger connection between formal and informal education. The presentation will also discuss how Gas Giants, a proposed 4000 square-foot traveling exhibition on the mysteries and discoveries of the outer planets, will be able to take advantage of the connections and resources that have been developed by the MarsQuest project.

  11. 15 CFR 18.12 - Net worth exhibit.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Net worth exhibit. 18.12 Section 18.12... Information Required from Applicants § 18.12 Net worth exhibit. (a) Each applicant except a qualified tax... showing the net worth of the applicant and any affiliates (as defined in § 18.5(f) of this part) when...

  12. 15 CFR 18.12 - Net worth exhibit.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Net worth exhibit. 18.12 Section 18.12... Information Required from Applicants § 18.12 Net worth exhibit. (a) Each applicant except a qualified tax... showing the net worth of the applicant and any affiliates (as defined in § 18.5(f) of this part) when...

  13. 15 CFR 18.12 - Net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Net worth exhibit. 18.12 Section 18.12... Information Required from Applicants § 18.12 Net worth exhibit. (a) Each applicant except a qualified tax... showing the net worth of the applicant and any affiliates (as defined in § 18.5(f) of this part) when...

  14. 15 CFR 18.12 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Net worth exhibit. 18.12 Section 18.12... Information Required from Applicants § 18.12 Net worth exhibit. (a) Each applicant except a qualified tax... showing the net worth of the applicant and any affiliates (as defined in § 18.5(f) of this part) when...

  15. Evaluating Education and Science in the KSC Visitor Complex Exhibits

    NASA Technical Reports Server (NTRS)

    Erickson, Lance K.

    2000-01-01

    The continuing development of exhibits at the Kennedy Space Center's Visitor Complex is an excellent opportunity for NASA personnel to promote science and provide insight into NASA programs and projects for the approximately 3 million visitors that come to KSC annually. Stated goals for the Visitor Complex, in fact, emphasize science awareness and recommend broadening the appeal of the displays and exhibits for all age groups. To this end, this summer project seeks to evaluate the science content of planned exhibits/displays in relation to these developing opportunities and identify specific areas for enhancement of existing or planned exhibits and displays. To help expand the educational and science content within the developing exhibits at the Visitor Complex, this project was structured to implement the goals of the Visitor Center Director. To accomplish this, the exhibits and displays planned for completion within the year underwent review and evaluation for science content and educational direction. Planning emphasis for the individual displays was directed at combining the elements of effective education with fundamental scientific integrity, within an appealing format.

  16. Reductive Dissolution of Goethite and Hematite by Reduced Flavins

    SciTech Connect

    Shi, Zhi; Zachara, John M.; Wang, Zheming; Shi, Liang; Fredrickson, Jim K.

    2013-10-02

    The abiotic reductive dissolution of goethite and hematite by the reduced forms of flavin mononucleotide (FMNH2) and riboflavin (RBFH2), electron transfer mediators (ETM) secreted by the dissimilatory iron-reducing bacterium Shewanella, was investigated under stringent anaerobic conditions. In contrast to the rapid redox reaction rate observed for ferrihydrite and lepidocrocite (Shi et al., 2012), the reductive dissolution of crystalline goethite and hematite was slower, with the extent of reaction limited by the thermodynamic driving force at circumneutral pH. Both the initial reaction rate and reaction extent increased with decreasing pH. On a unit surface area basis, goethite was less reactive than hematite between pH 4.0 and 7.0. AH2DS, the reduced form of the well-studied synthetic ETM anthraquinone-2,6-disulfonate (AQDS), yielded higher rates than FMNH2 under most reaction conditions, despite the fact that FMNH2 was a more effective reductant than AH2DS for ferryhydrite and lepidocrocite. Two additional model compounds, methyl viologen and benzyl viologen, were investigated under similar reaction conditions to explore the relationship between reaction rate and thermodynamic properties. Relevant kinetic data from the literature were also included in the analysis to span a broad range of half-cell potentials. Other conditions being equal, the surface area normalized initial reaction rate (ra) increased as the redox potential of the reductant became more negative. A non-linear, parabolic relationship was observed between log ra and the redox potential for eight reducants at pH 7.0, as predicted by Marcus theory for electron transfer. When pH and reductant concentration were fixed, log ra was positively correlated to the redox potential of four Fe(III) oxides over a wide pH range, following a non-linear parabolic relationship as well.

  17. A phenomenological investigation of science center exhibition developers' expertise development

    NASA Astrophysics Data System (ADS)

    Young, Denise L.

    The purpose of this study was to examine the exhibition developer role in the context of United States (U.S.) science centers, and more specifically, to investigate the way science center exhibition developers build their professional expertise. This research investigated how successfully practicing exhibition developers described their current practices, how they learned to be exhibition developers, and what factors were the most important to the developers in building their professional expertise. Qualitative data was gathered from 10 currently practicing exhibition developers from three science centers: the Exploratorium, San Francisco, California; the Field Museum, Chicago, Illinois; and the Science Museum of Minnesota, St. Paul, Minnesota. In-depth, semistructured interviews were used to collect the data. The study embraced aspects of the phenomenological tradition and sought to derive a holistic understanding of the position and how expertise was built for it. The data were methodically coded and organized into themes prior to analysis. The data analysis found that the position consisted of numerous and varied activities, but the developers' primary roles were advocating for the visitor, storytelling, and mediating information and ideas. They conducted these activities in the context of a team and relied on an established exhibition planning process to guide their work. Developers described a process of learning exhibition development that was experiential in nature. Learning through daily practice was key, though they also consulted with mentors and relied on visitor studies to gauge the effectiveness of their work. They were adept at integrating prior knowledge gained from many aspects of their lives into their practice. The developers described several internal factors that contributed to their expertise development including the desire to help others, a natural curiosity about the world, a commitment to learning, and the ability to accept critique. They

  18. Black Holes Traveling Exhibition: This Time, It's Personal.

    NASA Astrophysics Data System (ADS)

    Dussault, Mary E.; Braswell, E. L.; Sunbury, S.; Wasser, M.; Gould, R. R.

    2012-01-01

    How can you make a topic as abstract as black holes seem relevant to the life of the average museum visitor? In 2009, the Harvard-Smithsonian Center for Astrophysics developed a 2500 square foot interactive museum exhibition, "Black Holes: Space Warps & Time Twists,” with funding from the National Science Foundation and NASA. The exhibition has been visited by more than a quarter million museum-goers, and is about to open in its sixth venue at the Reuben H. Fleet Science Center in San Diego, California. We have found that encouraging visitors to adopt a custom black hole explorer's identity can help to make the science of black holes more accessible and meaningful. The Black Holes exhibition uses networked exhibit technology that serves to personalize the visitor experience, to support learning over time including beyond the gallery, and to provide a rich quantitative source of embedded evaluation data. Visitors entering the exhibition create their own bar-coded "Black Holes Explorer's Card” which they use throughout the exhibition to collect and record images, movies, their own predictions and conclusions, and other black hole artifacts. This digital database of personal discoveries grows as visitors navigate through the gallery, and an automated web-content authoring system creates a personalized online journal of their experience that they can access once they get home. We report here on new intriguing results gathered from data generated by 112,000 visitors across five different venues. For example, an initial review of the data reveals correlations between visitors’ black hole explorer identity choices and their engagement with the exhibition. We will also discuss correlations between learning gains and personalization.

  19. The Powerful Educational Potential of Traveling Space Science Exhibits

    NASA Astrophysics Data System (ADS)

    Morrow, C. A.; Dusenbery, P. B.; Harold, J. H.

    2003-04-01

    Five traveling exhibits (both large and small) related to space science are currently touring the U. S., and two more have recently been funded by the National Science Foundation and NASA. These extraordinary educational resources address topics like space weather, Mars exploration, cosmology, the results of Hubble Space Telescope, and the origins of stars, planets, and life. The Space Science Institute (SSI) of Boulder, Colorado, plays leadership roles in four of the seven exhibits. This paper will summarize the nature and itineraries of these exhibits, and how they serve as rallying points for education and public outreach activities across the entire spectrum of science communication. The talk will give special attention to workshops SSI has conducted at MarsQuest host sites for museum educators, docents, and local educators to bolster the host site's ability to do programming around the exhibit content. These workshops have shown promise of leaving a host site with a legacy of new educational capabilities and enhanced connectivity with space scientists and educators in the region. The talk will also address progress on the MarsQuest On-Line project which uses the 5000 sq ft (500 sq m) exhibit as a conceptual framework for an interactive website.

  20. Liberty Bell 7 Space Capsule Exhibit previews at Visitor Complex

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Children on a tour at the KSC Visitor Complex get an early look at the Discovery Channel's Liberty Bell 7 Space Capsule Exhibit, which opens to the public on Saturday, June 17. They are on a re- creation of the deck of Ocean Project, the ship that located and recovered the space capsule from the floor of the Atlantic Ocean. Liberty Bell 7 launched U.S. Air Force Captain Virgil '''Gus''' Grissom July 21, 1961, on a mission that lasted 15 minutes and 37 seconds before sinking. It lay undetected for nearly four decades before a Discovery Channel expedition located it and recovered it. The space capsule, now restored and preserved, is part of an interactive exhibit touring science centers and museums in 12 cities throughout the United States until 2003. The exhibit also includes hands-on elements such as a capsule simulator, a centrifuge, and ROV pilot.

  1. Space Research Institute (IKI) Exhibition as an Educational Project

    NASA Astrophysics Data System (ADS)

    Sadovski, Andrei; Antonenko, Elena

    2016-07-01

    The Exhibition "Space Science: Part and Future" in Space Research Institute (IKI) was opened in 2007 in commemoration of the 50th anniversary of the first man-made satellite launch. It covers the latest and the most important findings in space research, shows instruments which are used in space exploration, and presents past, current, and future Russian science missions. Prototypes of space instruments developed by Russian specialists and mockups of spacecraft and spaceships flown to space are displayed, together with information posters, describing space missions, their purposes and results. The Exhibition takes a great part in school space education. Its stuff actively works with schoolchildren, undergraduate students and also makes a great contribution in popularization of space researches. Moreover the possibility to learn about scientific space researches first-hand is priceless. We describe the main parts of the Exhibition and forms of it work and also describe the collaboration with other museums and educational organizations.

  2. Visions of the Universe: How Library Exhibits Impact Communities

    NASA Astrophysics Data System (ADS)

    Eisenhamer, Bonnie; McCallister, D.; Summers, F.; Smith, D.; Ryer, H.

    2010-01-01

    In turning his telescope to the heavens in 1609, Galileo Galilei embarked upon a journey that would revolutionize science and culture alike, profoundly changing our view of our place in the universe. In celebration of this achievement and the International Year of Astronomy (IYA), the Space Telescope Science Institute produced the "Visions of the Universe: Four Centuries of Discovery” exhibit in partnership with the American Library Association. The "Visions of the Universe” exhibit shows how humanity's views and understanding of the universe have changed over the past four hundred years, and addresses topics such as storms on the sun, Saturn's rings, the nature of comets, star birth, and distant galaxies. As part of its evaluation program, STScI's Office of Public Outreach has been conducting an evaluation of the exhibit to determine its effectiveness in meeting the needs of libraries across the United States. This poster will highlight data collected from libraries and preliminary findings.

  3. One exhibition, many goals. Combining scientific research and risk communication

    NASA Astrophysics Data System (ADS)

    Charrière, Marie; Bogaard, Thom; Junier, Sandra; Malet, Jean-Philippe; Mostert, Erik

    2015-04-01

    How effective is visual communication to increase awareness of natural hazards and risks? To answer this research question, we developed a research design that was at the same time an experimental setting and an actual communication effort. Throughout the full length of the 2-years project held in the Ubaye valley (southeastern France), we collaborated with local and regional stakeholders (politicians and technicians). During a consultation phase, the communication context was determined, the audience of the project was defined and finally the testing activity-communication effort was determined. We were offered the opportunity to design an exhibition for the local public library. In a consultation phase that corresponded to the design of the exhibition, the stakeholders contributed to its content as well as helping with the funding of the exhibition. Finally, during the experimentation phase, the stakeholders participated in advertising the activity, gathering of participants and designing the scientific survey. In order to assess the effects of the exhibition on risk awareness, several groups of children, teenagers and adults were submitted to a research design, consisting of 1) a pre-test, 2) the visit of the exhibition and 3) a post-test similar to the pre-test. In addition, the children answered a second post-test 3 months after the visit. Close ended questions addressed the awareness indicators mentioned in the literature, i.e. worry level, previous experiences with natural hazards events, exposure to awareness raising, ability to mitigate/respond/prepare, attitude to risk, and demographics. In addition, the post-test included several satisfaction questions concerning the visual tools displayed in the exhibition. A statistical analysis of the changes between the pre- and post- tests (paired t-test, Wilcoxon signed-rank test and bootstrapping) allowed to verify whether the exhibition had an impact on risk awareness or not. In order to deduce which variable

  4. 7 CFR 28.126 - Loaning of forms and exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS COTTON CLASSING, TESTING, AND STANDARDS Regulations Under the United States Cotton Standards Act... 7 Agriculture 2 2010-01-01 2010-01-01 false Loaning of forms and exhibits. 28.126 Section 28.126 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE...

  5. Do Online Learning Patterns Exhibit Regional and Demographic Differences?

    ERIC Educational Resources Information Center

    Hsieh, Tsui-Chuan; Yang, Chyan

    2012-01-01

    This paper used a multi-level latent class model to evaluate whether online learning patterns exhibit regional differences and demographics. This study discovered that the Internet learning pattern consists of five segments, and the region of Taiwan is divided into two segments and further found that both the user and the regional segments are…

  6. 14 CFR Appendix to Subpart A of... - Listing of Exhibits

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Listing of Exhibits Appendix to Subpart A of Part 1260 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Pt. 1260, Subpt. A, App. Appendix to Subpart A of Part 1260—Listing of...

  7. 14 CFR Appendix to Subpart A of... - Listing of Exhibits

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Listing of Exhibits Appendix to Subpart A of Part 1260 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Pt. 1260, Subpt. A, App. Appendix to Subpart A of Part 1260—Listing of...

  8. 14 CFR Appendix to Subpart A of... - Listing of Exhibits

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Listing of Exhibits Appendix to Subpart A of Part 1260 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Pt. 1260, Subpt. A, App. Appendix to Subpart A of Part 1260—Listing of...

  9. 14 CFR Appendix to Subpart A of... - Listing of Exhibits

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Listing of Exhibits Appendix to Subpart A of Part 1260 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GRANTS AND COOPERATIVE AGREEMENTS General Pt. 1260, Subpt. A, App. Appendix to Subpart A of Part 1260—Listing of...

  10. 17 CFR 229.601 - (Item 601) Exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... material to an investor and a representation as to tax consequences is set forth in the filing. If a tax... personal agreements whose disclosure in an exhibit is necessary to an investor's understanding of that... securities to be offered at competitive bidding, any form of communication which is an invitation...

  11. 18 CFR 157.16 - Exhibits relating to acquisitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Exhibits relating to acquisitions. 157.16 Section 157.16 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF...

  12. 18 CFR 157.16 - Exhibits relating to acquisitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Exhibits relating to acquisitions. 157.16 Section 157.16 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF...

  13. 18 CFR 157.16 - Exhibits relating to acquisitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Exhibits relating to acquisitions. 157.16 Section 157.16 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF...

  14. AERIAL OF VISITORS INFORMATION CENTER [VIC] & ROCKET GARDEN EXHIBIT

    NASA Technical Reports Server (NTRS)

    1975-01-01

    AERIAL OF VISITORS INFORMATION CENTER [VIC] & ROCKET GARDEN EXHIBIT KSC-375C-0604.12 116-KSC-375C-604.12, P-20220, ARCHIVE-04465 Aerial view of Kennedy Space Center Visitors Information Center looking east-northeastward. New food services building under construction is visible at upper left.

  15. 12 CFR 1203.11 - Confidentiality of net worth exhibit.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Confidentiality of net worth exhibit. 1203.11 Section 1203.11 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 1203.11 Confidentiality of net worth...

  16. Explanatory Parent-Child Conversation Predominates at an Evolution Exhibit

    ERIC Educational Resources Information Center

    Tare, Medha; French, Jason; Frazier, Brandy N.; Diamond, Judy; Evans, E. Margaret

    2011-01-01

    To investigate how parents support children's learning at an exhibit on evolution, the conversations of 12 families were recorded, transcribed, and coded (6,263 utterances). Children (mean age 9.6 years) and parents visited Explore Evolution, which conveyed current research about the evolution of seven organisms. Families were engaged with the…

  17. Computerizing Museum Exhibits: The Beginnings of the Essential Conversation

    ERIC Educational Resources Information Center

    Burdick, Bruce

    1978-01-01

    Examples are given of some types of interaction between viewed and museum provided by an experimental computer based nutrition exhibit at the Chicago Museum of Science and Industry. Plans are being developed for a museum in which most of the information conveyed will appear through the use of video systems tied to a computer. (CMV)

  18. 17 CFR 229.601 - (Item 601) Exhibits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false (Item 601) Exhibits. 229.601 Section 229.601 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD... sales agency agreements. (2) Agreements with managers of stores in a chain organization or...

  19. 17 CFR 229.601 - (Item 601) Exhibits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false (Item 601) Exhibits. 229.601 Section 229.601 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD... agreements. (2) Agreements with managers of stores in a chain organization or similar organization....

  20. 17 CFR 229.601 - (Item 601) Exhibits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false (Item 601) Exhibits. 229.601 Section 229.601 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD... sales agency agreements. (2) Agreements with managers of stores in a chain organization or...

  1. 40 CFR 17.12 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... including the affiliates. The exhibit may be in any form that provides full disclosure of assets and liabilities of the applicant and any affiliates and is sufficient to determine whether the applicant qualifies... describe any transfers of assets from, or obligations incurred by, the applicant or any affiliate...

  2. 45 CFR 13.11 - Net worth exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... disclosure of the applicant's and its affiliates' assets and liabilities and is sufficient to determine... exhibit shall describe any transfers of assets from, or obligations incurred by, the applicant or any... confidentiality. (Approved by the Office of Management and Budget under control number 0990-0118)...

  3. 45 CFR 1160.5 - Eligibility for domestic exhibitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... while on Exhibition in the United States. (a)(1) Example 1. An American museum is undergoing renovation... go on tour to three other museums in the United States. Many of these works have never been lent for travel, and this will be a unique and the last opportunity for museum visitors in other parts of...

  4. 45 CFR 1160.5 - Eligibility for domestic exhibitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... while on Exhibition in the United States. (a)(1) Example 1. An American museum is undergoing renovation... go on tour to three other museums in the United States. Many of these works have never been lent for travel, and this will be a unique and the last opportunity for museum visitors in other parts of...

  5. 45 CFR 1160.5 - Eligibility for domestic exhibitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... while on Exhibition in the United States. (a)(1) Example 1. An American museum is undergoing renovation... go on tour to three other museums in the United States. Many of these works have never been lent for travel, and this will be a unique and the last opportunity for museum visitors in other parts of...

  6. 45 CFR 1160.5 - Eligibility for domestic exhibitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... while on Exhibition in the United States. (a)(1) Example 1. An American museum is undergoing renovation... go on tour to three other museums in the United States. Many of these works have never been lent for travel, and this will be a unique and the last opportunity for museum visitors in other parts of...

  7. 45 CFR 1160.5 - Eligibility for domestic exhibitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... while on Exhibition in the United States. (a)(1) Example 1. An American museum is undergoing renovation... go on tour to three other museums in the United States. Many of these works have never been lent for travel, and this will be a unique and the last opportunity for museum visitors in other parts of...

  8. 18 CFR 157.16 - Exhibits relating to acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Exhibits relating to acquisitions. 157.16 Section 157.16 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Infrastructure Information (CEII), as defined by § 388.113(c) of this chapter, to any person, the applicant...

  9. 18 CFR 157.16 - Exhibits relating to acquisitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Exhibits relating to acquisitions. 157.16 Section 157.16 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Infrastructure Information (CEII), as defined by § 388.113(c) of this chapter, to any person, the applicant...

  10. 9. COPY OF PHOTOGRAPHIC EXHIBIT BOARD CREATED 19481949 SHOWING CONSTRUCTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. COPY OF PHOTOGRAPHIC EXHIBIT BOARD CREATED 1948-1949 SHOWING CONSTRUCTION OF ARCH HANGAR. BOARD LOCATED AT AIR FORCE BASE CONVERSION AGENCY, LORING AIR FORCE BASE, MAINE. - Loring Air Force Base, Arch Hangar, East of Arizona Road near southern end of runway, Limestone, Aroostook County, ME

  11. 7 CFR Appendix - Exhibits to Subpart E of Part 1951

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Exhibits to Subpart E of Part 1951 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) SERVICING...

  12. 22 CFR Exhibit B to Part 204 - Assignment

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Assignment B Exhibit B to Part 204 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT HOUSING GUARANTY STANDARD TERMS AND CONDITIONS Pt. 204, Exh... Agency for International Development (“A.I.D.”), hereby assigns to A.I.D., without recourse (i)...

  13. (Un)Disturbing Exhibitions: Indigenous Historical Memory at the NMAI

    ERIC Educational Resources Information Center

    Carpio, Myla Vicenti

    2006-01-01

    Museums in particular are educational tools used to create and perpetuate specific ideologies and historical memories. They have played a prominent role in defining the visibility of Indigenous peoples and cultures in America historical memory by creating exhibits of Indigenous peoples based on perceptions and views that benefit and justify…

  14. Curriculum Activities Guide for Natural History Exhibits, Grades K-8.

    ERIC Educational Resources Information Center

    International Wildlife Museum, Tucson, AZ.

    A natural history museum is a building where animals, plants, minerals, and other things in nature are kept and exhibited for study. This document is a curriculum guide to provide a variety of activities for educators and their students to use not only when visiting the International Wildlife Museum (Tuscon, Arizona), but also with natural history…

  15. Grandma Moses in the 21st Century. Learning from Exhibitions.

    ERIC Educational Resources Information Center

    Johnson, Mark M.

    2001-01-01

    Provides background information on the life and career of Grandma Moses who was born as Anna Mary Robertson and painted in the style of folk or naive art. Addresses the art exhibition entitled "Grandma Moses in the 21st Century" that explores the recurring themes in her artwork. (CMK)

  16. 13. VIEW OF RAILROAD EXHIBIT AT EL PORTAL. SHAY LOCOMOTIVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. VIEW OF RAILROAD EXHIBIT AT EL PORTAL. SHAY LOCOMOTIVE IS FROM THE HETCH HETCHY RAILROAD. CABOOSE IS FROM THE YOSEMITE VALLEY RAILROAD. FOREST ROAD IN FOREGROUND IS THE ALIGNMENT OF THE YOSEMITE VALLEY RAILROAD. LOOKING W. GIS: N-37 40 27.0 / W-119 47 10.5 - Yosemite National Park Roads & Bridges, Yosemite Village, Mariposa County, CA

  17. Take To the Streets: Guide To Planning Outdoor, Public Exhibits.

    ERIC Educational Resources Information Center

    Cutting, Jennifer McGregor; And Others

    Placing exhibits in public places provides a unique opportunity to reach a broad non-museum-going audience. It offers marketing and publicity opportunities as well as the potential to develop relationships with agencies and individuals who are stakeholders in the public site. The purpose of this guidebook is to describe the steps in creating an…

  18. 7 CFR Exhibit B to Subpart B of... - Servicing Company

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false Servicing Company B Exhibit B to Subpart B of Part 1806 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... of Part 1806—Servicing Company The servicing company office to be contacted for information...

  19. 7 CFR Exhibit B to Subpart B of... - Servicing Company

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Servicing Company B Exhibit B to Subpart B of Part 1806 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... of Part 1806—Servicing Company The servicing company office to be contacted for information...

  20. 7 CFR Exhibit B to Subpart B of... - Servicing Company

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Servicing Company B Exhibit B to Subpart B of Part 1806 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... of Part 1806—Servicing Company The servicing company office to be contacted for information...

  1. 7 CFR Exhibit B to Subpart B of... - Servicing Company

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Servicing Company B Exhibit B to Subpart B of Part 1806 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... of Part 1806—Servicing Company The servicing company office to be contacted for information...

  2. 7 CFR Exhibit B to Subpart B of... - Servicing Company

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false Servicing Company B Exhibit B to Subpart B of Part 1806 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL... of Part 1806—Servicing Company The servicing company office to be contacted for information...

  3. 63. View of Klystron tube cutaway exhibit located at mezzanine ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. View of Klystron tube cut-away exhibit located at mezzanine level transmitter building no. 102, directly above RF power generation systems located on first floor. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  4. 45 CFR 1160.4 - Eligibility for international exhibitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS... whole. (d)(1) Example. An American art museum is organizing a retrospective exhibition which will include more than 150 works of art by Impressionist painter Auguste Renoir. Museums in Paris and...

  5. 45 CFR 1160.4 - Eligibility for international exhibitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS... whole. (d)(1) Example. An American art museum is organizing a retrospective exhibition which will include more than 150 works of art by Impressionist painter Auguste Renoir. Museums in Paris and...

  6. 45 CFR 1160.4 - Eligibility for international exhibitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS... whole. (d)(1) Example. An American art museum is organizing a retrospective exhibition which will include more than 150 works of art by Impressionist painter Auguste Renoir. Museums in Paris and...

  7. 45 CFR 1160.4 - Eligibility for international exhibitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS... whole. (d)(1) Example. An American art museum is organizing a retrospective exhibition which will include more than 150 works of art by Impressionist painter Auguste Renoir. Museums in Paris and...

  8. 45 CFR 1160.4 - Eligibility for international exhibitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... THE ARTS AND THE HUMANITIES FEDERAL COUNCIL ON THE ARTS AND THE HUMANITIES INDEMNITIES UNDER THE ARTS... whole. (d)(1) Example. An American art museum is organizing a retrospective exhibition which will include more than 150 works of art by Impressionist painter Auguste Renoir. Museums in Paris and...

  9. Herbert Hoover Library & Museum: A Guide to the Exhibit Galleries.

    ERIC Educational Resources Information Center

    Smith, Richard Norton; And Others

    This guide book is used to accompany the exhibits at the Herbert Hoover Presidential Library and Museum. The guide provides a basic overview of the life and contributions of Herbert Hoover and can be read independent of a tour of the galleries. The book contains the following chapters: (1) "Years of Adventure"; (2) "The Great…

  10. The "Gravity-Powered Calculator," a Galilean Exhibit

    ERIC Educational Resources Information Center

    Cerreta, Pietro

    2014-01-01

    The Gravity-Powered Calculator is an exhibit of the Exploratorium in San Francisco. It is presented by its American creators as an amazing device that extracts the square roots of numbers, using only the force of gravity. But if you analyze his concept construction one can not help but recall the research of Galileo on falling bodies, the inclined…

  11. The Cheapbook: A Compendium of Inexpensive Exhibit Ideas, 1995 Edition.

    ERIC Educational Resources Information Center

    Orselli, Paul, Ed.

    This guide includes complete installation descriptions of 30 exhibits. They include: the adjustable birthday cake, ball-in-tube, Bernoulli Box, chain wave, collapsible truss bridge, double wave device, eddy currents raceway, full-length mirror, geodesic domes, giant magnetic tangrams, harmonic cantilever, hyperboloid of revolution, lifting lever,…

  12. Exhibition of Humanities Portfolio with a Latino Urban Population.

    ERIC Educational Resources Information Center

    Estrada, Christelle L. Martinez

    1995-01-01

    Pasadena (California) High School's Puente Pilot Project encourages Hispanic students to pursue college and return home as leaders and mentors. A bilingual counselor, community liaison, and English teacher engage students in an integrated curriculum relevant to their life experiences. Portfolio exhibitions involving oral presentation and…

  13. Proceedings of the 1991 SPE annual technical conference and exhibition

    SciTech Connect

    Not Available

    1991-01-01

    This book contains the proceedings of the 1991 SDE Annual Technical Conference and Exhibition with some of the following topics. A comparison of MWD and wireless steering tool guidance systems in horizontal drilling; Anger TLP; Drilling engineering overview; Safety of casing shoe test and casing shoe integrity after testing; Zero discharge design considerations for jackey drilling rigs.

  14. 27 CFR 4.51 - Exhibiting certificates to Government officials.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Exhibiting certificates to Government officials. 4.51 Section 4.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Requirements...

  15. 27 CFR 4.51 - Exhibiting certificates to Government officials.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Exhibiting certificates to Government officials. 4.51 Section 4.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Requirements...

  16. 27 CFR 4.51 - Exhibiting certificates to Government officials.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Exhibiting certificates to Government officials. 4.51 Section 4.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LABELING AND ADVERTISING OF WINE Requirements...

  17. 27 CFR 4.51 - Exhibiting certificates to Government officials.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Exhibiting certificates to Government officials. 4.51 Section 4.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY ALCOHOL LABELING AND ADVERTISING OF WINE Requirements...

  18. 27 CFR 4.51 - Exhibiting certificates to Government officials.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Exhibiting certificates to Government officials. 4.51 Section 4.51 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Requirements...

  19. Opa+ Neisseria gonorrhoeae Exhibits Reduced Survival in Human Neutrophils Via Src Family Kinase-Mediated Bacterial Trafficking Into Mature Phagolysosomes

    PubMed Central

    Johnson, M. Brittany; Ball, Louise M.; Daily, Kylene P.; Martin, Jennifer N.; Columbus, Linda; Criss, Alison K.

    2015-01-01

    Summary During gonorrheal infection, there is a heterogeneous population of Neisseria gonorrhoeae (Gc) varied in their expression of opacity-associated (Opa) proteins. While Opa proteins are important for bacterial attachment and invasion of epithelial cells, Opa+ Gc has a survival defect after exposure to neutrophils. Here, we use constitutively Opa- and OpaD+ Gc in strain background FA1090 to show that Opa+ Gc is more sensitive to killing inside adherent, chemokine-treated primary human neutrophils due to increased bacterial residence in mature, degradative phagolysosomes that contain primary and secondary granule antimicrobial content. Although Opa+ Gc stimulates a potent oxidative burst, neutrophil killing of Opa+ Gc was instead attributable to non-oxidative components, particularly neutrophil proteases and the bactericidal/permeability-increasing protein. Blocking interaction of Opa+ Gc with carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) or inhibiting Src family kinase signaling, which is downstream of CEACAM activation, enhanced the survival of Opa+ Gc in neutrophils. Src family kinase signaling was required for fusion of Gc phagosomes with primary granules to generate mature phagolysosomes. Conversely, ectopic activation of Src family kinases or coinfection with Opa+ Gc resulted in decreased survival of Opa- Gc in neutrophils. From these results, we conclude that Opa protein expression is an important modulator of Gc survival characteristics in neutrophils by influencing phagosome dynamics and thus bacterial exposure to neutrophils’ full antimicrobial arsenal. PMID:25346239

  20. Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function.

    PubMed

    Portugal, Silvia; Tipton, Christopher M; Sohn, Haewon; Kone, Younoussou; Wang, Jing; Li, Shanping; Skinner, Jeff; Virtaneva, Kimmo; Sturdevant, Daniel E; Porcella, Stephen F; Doumbo, Ogobara K; Doumbo, Safiatou; Kayentao, Kassoum; Ongoiba, Aissata; Traore, Boubacar; Sanz, Inaki; Pierce, Susan K; Crompton, Peter D

    2015-05-08

    Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a large increase in atypical memory B cells (MBCs) that resemble B cells expanded in a variety of persistent viral infections. Understanding the function of atypical MBCs and their relationship to classical MBCs will be critical to developing effective vaccines for malaria and other chronic infections. We show that VH gene repertoires and somatic hypermutation rates of atypical and classical MBCs are indistinguishable indicating a common developmental history. Atypical MBCs express an array of inhibitory receptors and B cell receptor (BCR) signaling is stunted in atypical MBCs resulting in impaired B cell responses including proliferation, cytokine production and antibody secretion. Thus, in response to chronic malaria exposure, atypical MBCs appear to differentiate from classical MBCs becoming refractory to BCR-mediated activation and potentially interfering with the acquisition of malaria immunity.