Modification of turbulent particle transport and intermittency by biased rotation in LAPD

NASA Astrophysics Data System (ADS)

Dove, J.; Carter, T. A.; Maggs, J. E.

2006-10-01

The edge plasma in LAPD is rotated through the application of a bias voltage between the plasma source cathode and the vacuum vessel wall. As the bias voltage is applied and increased past a threshold value, the measured density profile steepens dramatically (from Ln> 10 ρs to Ln˜2 ρs) at a radius near the peak of the flow shear. Turbulent transport flux measurements in this region show that the flux is reduced and then suppressed completely as the threshold is approached. The amplitude of the density and azimuthal electric field fluctuations is observed to decrease during biased rotation, the product of the amplitudes decreasing by a factor of 5. However the dominant change appears in the cross-phase, which is altered dramatically, leading to the observed suppression and reversal of the turbulent flux. Detailed two-dimensional turbulent correlation measurements have been performed. During biased rotation, a dramatic increase in the azimuthal correlation is observed, however there is little change in the radial correlation length. An investigation of the modification of intermittent (or ``blobby'') transport due to the shear flow is underway and initial results will be presented.

Contrasting watershed-scale trends in runoff and sediment yield complicate rangeland water resources planning

NASA Astrophysics Data System (ADS)

Berg, Matthew D.; Marcantonio, Franco; Allison, Mead A.; McAlister, Jason; Wilcox, Bradford P.; Fox, William E.

2016-06-01

Rangelands cover a large portion of the earth's land surface and are undergoing dramatic landscape changes. At the same time, these ecosystems face increasing expectations to meet growing water supply needs. To address major gaps in our understanding of rangeland hydrologic function, we investigated historical watershed-scale runoff and sediment yield in a dynamic landscape in central Texas, USA. We quantified the relationship between precipitation and runoff and analyzed reservoir sediment cores dated using cesium-137 and lead-210 radioisotopes. Local rainfall and streamflow showed no directional trend over a period of 85 years, resulting in a rainfall-runoff ratio that has been resilient to watershed changes. Reservoir sedimentation rates generally were higher before 1963, but have been much lower and very stable since that time. Our findings suggest that (1) rangeland water yields may be stable over long periods despite dramatic landscape changes while (2) these same landscape changes influence sediment yields that impact downstream reservoir storage. Relying on rangelands to meet water needs demands an understanding of how these dynamic landscapes function and a quantification of the physical processes at work.

Education for Sustainability: The Need for a New Human Perspective.

ERIC Educational Resources Information Center

Cortese, Anthony

Disturbing global trends show that human activity continues to threaten our ability to meet current human needs without compromising the ability of future generations to meet their own needs. Sustainability will become more inaccessible without a dramatic change in our current mindset and behavior. As the primary centers of teaching, research, and…

Method Matters: Systematic Effects of Testing Procedure on Visual Working Memory Sensitivity

ERIC Educational Resources Information Center

Makovski, Tal; Watson, Leah M.; Koutstaal, Wilma; Jiang, Yuhong V.

2010-01-01

Visual working memory (WM) is traditionally considered a robust form of visual representation that survives changes in object motion, observer's position, and other visual transients. This article presents data that are inconsistent with the traditional view. We show that memory sensitivity is dramatically influenced by small variations in the…

Dramatic Change in Jupiter's Great Red Spot

NASA Technical Reports Server (NTRS)

Simon, A. A.; Wong, M. H.; Rogers, J. H.; Orton, G. S.; de Pater, I.; Asay-Davis, X.; Carlson, R. W.; Marcus, P. S.

2015-01-01

Jupiter's Great Red Spot (GRS) is one of its most distinct and enduring features, having been continuously observed since the 1800's. It currently spans the smallest latitude and longitude size ever recorded. Here we show analyses of 2014 Hubble spectral imaging data to study the color, structure and internal dynamics of this long-live storm.

Impacts on Coralligenous Outcrop Biodiversity of a Dramatic Coastal Storm

PubMed Central

Teixidó, Núria; Casas, Edgar; Cebrián, Emma; Linares, Cristina; Garrabou, Joaquim

2013-01-01

Extreme events are rare, stochastic perturbations that can cause abrupt and dramatic ecological change within a short period of time relative to the lifespan of organisms. Studies over time provide exceptional opportunities to detect the effects of extreme climatic events and to measure their impacts by quantifying rates of change at population and community levels. In this study, we show how an extreme storm event affected the dynamics of benthic coralligenous outcrops in the NW Mediterranean Sea using data acquired before (2006–2008) and after the impact (2009–2010) at four different sites. Storms of comparable severity have been documented to occur occasionally within periods of 50 years in the Mediterranean Sea. We assessed the effects derived from the storm comparing changes in benthic community composition at sites exposed to and sheltered from this extreme event. The sites analyzed showed different damage from severe to negligible. The most exposed and impacted site experienced a major shift immediately after the storm, represented by changes in the species richness and beta diversity of benthic species. This site also showed higher compositional variability immediately after the storm and over the following year. The loss of cover of benthic species resulted between 22% and 58%. The damage across these species (e.g. calcareous algae, sponges, anthozoans, bryozoans, tunicates) was uneven, and those with fragile forms were the most impacted, showing cover losses up to 50 to 100%. Interestingly, small patches survived after the storm and began to grow slightly during the following year. In contrast, sheltered sites showed no significant changes in all the studied parameters, indicating no variations due to the storm. This study provides new insights into the responses to large and rare extreme events of Mediterranean communities with low dynamics and long-lived species, which are among the most threatened by the effects of global change. PMID:23326496

"Who should survive?: one of the choices on our conscience": mental retardation and the history of contemporary bioethics.

PubMed

Antommaria, Armand Matheny

2006-09-01

The film "Who Should Survive?: One of the Choices on Our Conscience" contains a dramatization of the death of an infant with Down syndrome as the result of the parents' decision not to have a congenital intestinal obstruction surgically corrected. The dramatization was based on two similar cases at The Johns Hopkins Hospital and was financed by the Joseph P. Kennedy, Jr., Foundation. When "Who Should Survive?" was exhibited in 1971, the public reaction was generally critical of the parents' decision and the physicians' inaction. Although technological developments in medicine were a necessary condition for the production of this film and its unanticipated reception, they were not a sufficient condition. The proximate cause was a changed understanding of the capabilities of individuals with Down syndrome. Part of the impetus for this change was data showing the adverse effects of institutionalization on normal children.

Massive formation of square array junctions dramatically alters cell shape but does not cause lens opacity in the cav1-KO mice.

PubMed

Biswas, Sondip K; Brako, Lawrence; Lo, Woo-Kuen

2014-08-01

The wavy square array junctions are composed of truncated aquaporin-0 (AQP0) proteins typically distributed in the deep cortical and nuclear fibers in wild-type lenses. These junctions may help maintain the narrowed extracellular spaces between fiber cells to minimize light scattering. Herein, we investigate the impact of the cell shape changes, due to abnormal formation of extensive square array junctions, on the lens opacification in the caveolin-1 knockout mice. The cav1-KO and wild-type mice at age 1-22 months were used. By light microscopy examinations, cav1-KO lenses at age 1-18 months were transparent in both cortical and nuclear regions, whereas some lenses older than 18 months old exhibited nuclear cataracts. Scanning EM consistently observed the massive formation of ridge-and-valley membrane surfaces in young fibers at approximately 150 μm deep in all cav1-KO lenses studied. In contrast, the typical ridge-and-valleys were only seen in mature fibers deeper than 400 μm in wild-type lenses. The resulting extensive ridge-and-valleys dramatically altered the overall cell shape in cav1-KO lenses. Remarkably, despite dramatic shape changes, these deformed fiber cells remained intact and made close contact with their neighboring cells. By freeze-fracture TEM, ridge-and-valleys exhibited the typical orthogonal arrangement of 6.6 nm square array intramembrane particles and displayed the narrowed extracellular spaces. Immunofluorescence analysis showed that AQP0 C-terminus labeling was significantly decreased in outer cortical fibers in cav1-KO lenses. However, freeze-fracture immunogold labeling showed that the AQP0 C-terminus antibody was sparsely distributed on the wavy square array junctions, suggesting that the cleavage of AQP0 C-termini might not yet be complete. The cav1-KO lenses with nuclear cataracts showed complete cellular breakdown and large globule formation in the lens nucleus. This study suggests that despite dramatic cell shape changes, the massive formation of wavy square array junctions in intact fibers may provide additional adhesive support for maintaining the narrowed extracellular spaces that are crucial for the transparency of cav1-KO lenses. Copyright © 2014 Elsevier Ltd. All rights reserved.

Observational Evidence of Changes in Soil Temperatures across Eurasian Continent

NASA Astrophysics Data System (ADS)

Zhang, T.

2015-12-01

Soil temperature is one of the key climate change indicators and plays an important role in plant growth, agriculture, carbon cycle and ecosystems as a whole. In this study, variability and changes in ground surface and soil temperatures up to 3.20 m were investigated based on data and information obtained from hydrometeorological stations across Eurasian continent since the early 1950s. Ground surface and soil temperatures were measured daily by using the same standard method and by the trained professionals across Eurasian continent, which makes the dataset unique and comparable over a large study region. Using the daily soil temperature profiles, soil seasonal freeze depth was also obtained through linear interpolation. Preliminary results show that soil temperatures at various depths have increased dramatically, almost twice as much as air temperature increase over the same period. Regionally, soil temperature increase was more dramatically in high northern latitudes than mid/lower latitude regions. Air temperature changes alone may not be able to fully explain the magnitude of changes in soil temperatures. Further study indicates that snow cover establishment started later in autumn and snow cover disappearance occurred earlier in spring, while winter snow depth became thicker with a decreasing trend of snow density. Changes in snow cover conditions may play an important role in changes of soil temperatures over the Eurasian continent.

Dramatic Teaching for Dramatic Learning

ERIC Educational Resources Information Center

Graves, Julie

2010-01-01

Ressler's "Dramatic Changes" is a powerful guide for anyone brave enough to create a space for young people to discuss sexual orientation and gender identity. Her accessible style and tangible suggestions describe a creative and educationally sound approach to supporting youth in thoughtfully wrestling with one of the most controversial social…

CD-ROM Technology: A Manual for Librarians and Educators.

ERIC Educational Resources Information Center

Mambretti, Catherine

The maturity of CD-ROM technology now shows a dramatic change in the way librarians and teachers do their jobs. Among their biggest challenges are deciding on equipment requirements and managing the disk collection. This manual is a step-by-step guide to making the most of CD-ROM technology in schools and libraries--from the acquisition of…

Accounting for multiple climate components when estimating climate change exposure and velocity

USGS Publications Warehouse

Nadeau, Christopher P.; Fuller, Angela K.

2015-01-01

The effect of anthropogenic climate change on organisms will likely be related to climate change exposure and velocity at local and regional scales. However, common methods to estimate climate change exposure and velocity ignore important components of climate that are known to affect the ecology and evolution of organisms.We develop a novel index of climate change (climate overlap) that simultaneously estimates changes in the means, variation and correlation between multiple weather variables. Specifically, we estimate the overlap between multivariate normal probability distributions representing historical and current or projected future climates. We provide methods for estimating the statistical significance of climate overlap values and methods to estimate velocity using climate overlap.We show that climates have changed significantly across 80% of the continental United States in the last 32 years and that much of this change is due to changes in the variation and correlation between weather variables (two statistics that are rarely incorporated into climate change studies). We also show that projected future temperatures are predicted to be locally novel (<1·5% overlap) across most of the global land surface and that exposure is likely to be highest in areas with low historical climate variation. Last, we show that accounting for changes in the variation and correlation between multiple weather variables can dramatically affect velocity estimates; mean velocity estimates in the continental United States were between 3·1 and 19·0 km yr−1when estimated using climate overlap compared to 1·4 km yr−1 when estimated using traditional methods.Our results suggest that accounting for changes in the means, variation and correlation between multiple weather variables can dramatically affect estimates of climate change exposure and velocity. These climate components are known to affect the ecology and evolution of organisms, but are ignored by most measures of climate change. We conclude with a set of future directions and recommend future work to determine which measures of climate change exposure and velocity are most related to biological responses to climate change.

Increased natural mortality at low abundance can generate an Allee effect in a marine fish.

PubMed

Kuparinen, Anna; Hutchings, Jeffrey A

2014-10-01

Negative density-dependent regulation of population dynamics promotes population growth at low abundance and is therefore vital for recovery following depletion. Inversely, any process that reduces the compensatory density-dependence of population growth can negatively affect recovery. Here, we show that increased adult mortality at low abundance can reverse compensatory population dynamics into its opposite-a demographic Allee effect. Northwest Atlantic cod (Gadus morhua) stocks collapsed dramatically in the early 1990s and have since shown little sign of recovery. Many experienced dramatic increases in natural mortality, ostensibly attributable in some populations to increased predation by seals. Our findings show that increased natural mortality of a magnitude observed for overfished cod stocks has been more than sufficient to fundamentally alter the dynamics of density-dependent population regulation. The demographic Allee effect generated by these changes can slow down or even impede the recovery of depleted populations even in the absence of fishing.

SERS of Individual Nanoparticles on a Mirror: Size Does Matter, but so Does Shape

PubMed Central

2016-01-01

Coupling noble metal nanoparticles by a 1 nm gap to an underlying gold mirror confines light to extremely small volumes, useful for sensing on the nanoscale. Individually measuring 10 000 of such gold nanoparticles of increasing size dramatically shows the different scaling of their optical scattering (far-field) and surface-enhanced Raman emission (SERS, near-field). Linear red-shifts of the coupled plasmon modes are seen with increasing size, matching theory. The total SERS from the few hundred molecules under each nanoparticle dramatically increases with increasing size. This scaling shows that maximum SERS emission is always produced from the largest nanoparticles, irrespective of tuning to any plasmonic resonances. Changes of particle facet with nanoparticle size result in vastly weaker scaling of the near-field SERS, without much modifying the far-field, and allows simple approaches for optimizing practical sensing. PMID:27223478

SERS of Individual Nanoparticles on a Mirror: Size Does Matter, but so Does Shape.

PubMed

Benz, Felix; Chikkaraddy, Rohit; Salmon, Andrew; Ohadi, Hamid; de Nijs, Bart; Mertens, Jan; Carnegie, Cloudy; Bowman, Richard W; Baumberg, Jeremy J

2016-06-16

Coupling noble metal nanoparticles by a 1 nm gap to an underlying gold mirror confines light to extremely small volumes, useful for sensing on the nanoscale. Individually measuring 10 000 of such gold nanoparticles of increasing size dramatically shows the different scaling of their optical scattering (far-field) and surface-enhanced Raman emission (SERS, near-field). Linear red-shifts of the coupled plasmon modes are seen with increasing size, matching theory. The total SERS from the few hundred molecules under each nanoparticle dramatically increases with increasing size. This scaling shows that maximum SERS emission is always produced from the largest nanoparticles, irrespective of tuning to any plasmonic resonances. Changes of particle facet with nanoparticle size result in vastly weaker scaling of the near-field SERS, without much modifying the far-field, and allows simple approaches for optimizing practical sensing.

Women as Workers.

ERIC Educational Resources Information Center

Barrett, Nancy S.

As increasing numbers of women make the transition from the household sector into the labor market, dramatic changes in household composition have occurred that have thrust many women into the role of provider. This new role for women has led to dramatic and rapid changes in attitudes, as well as in the institutions and laws relating to women's…

Dramatic Changes in Health Care Professions in the Past 40 Years.

PubMed

Goldfield, Norbert

During the forty-year life of the Journal of Ambulatory Care Management, revolutionary transformations have occurred in the roles of existing health professions, as has the emergence of new categories of health professionals. This paper specifies the reasons for these dramatic changes, the new types of health care professions that have emerged, changes in existing professions, and suggestions of future directions. Many of these changes will be impacted by what occurs in Washington, DC in the debate over the Accountable Care Act.

Modification of turbulence and turbulent transport associated with a confinement transition in LAPD

NASA Astrophysics Data System (ADS)

Carter, Troy

2009-11-01

Azimuthal flow is driven in the edge of the Large Plasma Device (LAPD) through biasing a section of the vacuum vessel relative to the plasma source cathode. As the applied bias exceeds a threshold, a transition in radial particle confinement is observed, evidenced by a dramatic steepening in the density profile, similar to the L- to H-mode transition in toroidal confinement devices. The threshold behavior and dynamic behavior of radial transport is related to flow penetration and the degree of spatial overlap between the flow shear and density gradient profiles. An investigation of the changes in turbulence and turbulent particle transport associated with the confinement transition is presented. Two-dimensional cross-correlation measurements show that the spatial coherence of edge turbulence in LAPD changes significantly with biasing. The azimuthal correlation in the turbulence increases dramatically, while the radial correlation length is little altered. Turbulent amplitude is reduced at the transition, particularly in electric field fluctuations, but the dominant change observed is in the cross-phase between density and electric field fluctuations. The changes in cross-phase lead to a suppression and then apparent reversal of turbulent particle flux as the threshold is exceeded.

Strategies of TV News Dramatization: An Attempt of Discourse Analysis.

ERIC Educational Resources Information Center

Mancini, Paolo

This paper defines indicators related to the dramatization of television and formulates a methodology for analyzing the discourse of the television news based on empirical studies. This methodology is used to isolate some indicators of dramatization as it relates to the structure and form of the message. The changes that have affected the text of…

Toyota's tips drive dramatic ED improvements.

PubMed

2002-11-01

The Toyota Motor Corp.'s key concepts of allowing workers to make changes, putting the customer first, and reducing waste can have a dramatic impact when implemented in emergency departments. Staff should be empowered to make changes to improve quality. A chain of events should be set in motion for each customer request. Identify and eliminate roadblocks that cause delays.

A review of abortion laws in Western-European countries. A cross-national comparison of legal developments between 1960 and 2010.

PubMed

Levels, Mark; Sluiter, Roderick; Need, Ariana

2014-10-01

The extent to which women have had access to legal abortions has changed dramatically in Western-Europe between 1960 and 2010. In most countries, abortion laws developed from completely banning abortion to allowing its availability on request. Both the timing and the substance of the various legal developments differed dramatically between countries. Existing comparative studies on abortion laws in Western-European countries lack detail, usually focus either on first-trimester abortions or second trimester abortions, cover a limited time-span and are sometimes inconsistent with one another. Combining information from various primary and secondary sources, we show how and when the conditions for legally obtaining abortion during the entire gestation period in 20 major Western-European countries have changed between 1960 and 2010. We also construct a cross-nationally comparable classification of procedural barriers that limit abortion access. Our cross-national comparison shows that Western-Europe witnessed a general trend towards decreased restrictiveness of abortion laws. However, legal approaches to regulating abortion are highly different in detail. Abortion access remains limited, sometimes even in countries where abortion is legally available without restrictions relating to reasons. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Change Detection: Training and Transfer

PubMed Central

Gaspar, John G.; Neider, Mark B.; Simons, Daniel J.; McCarley, Jason S.; Kramer, Arthur F.

2013-01-01

Observers often fail to notice even dramatic changes to their environment, a phenomenon known as change blindness. If training could enhance change detection performance in general, then it might help to remedy some real-world consequences of change blindness (e.g. failing to detect hazards while driving). We examined whether adaptive training on a simple change detection task could improve the ability to detect changes in untrained tasks for young and older adults. Consistent with an effective training procedure, both young and older adults were better able to detect changes to trained objects following training. However, neither group showed differential improvement on untrained change detection tasks when compared to active control groups. Change detection training led to improvements on the trained task but did not generalize to other change detection tasks. PMID:23840775

Amphibious fish jump better on land after acclimation to a terrestrial environment.

PubMed

Brunt, Emily M; Turko, Andy J; Scott, Graham R; Wright, Patricia A

2016-10-15

Air and water differ dramatically in density and viscosity, posing different biomechanical challenges for animal locomotion. We asked how terrestrial acclimation influences locomotion in amphibious fish, specifically testing the hypothesis that terrestrial tail flip performance is improved by plastic changes in the skeletal muscle. Mangrove rivulus Kryptolebias marmoratus, which remain largely inactive out of water, were exposed to water or air for 14 days and a subgroup of air-exposed fish was also recovered in water. Tail flip jumping performance on land improved dramatically in air-acclimated fish, they had lower lactate levels compared with control fish, and these effects were mostly reversible. Muscle plasticity significantly increased oxidative muscle cross-sectional area and fibre size, as well as the number of capillaries per fibre. Our results show that reversible changes to the oxidative skeletal muscle of K. marmoratus out of water enhance terrestrial locomotory performance, even in the absence of exercise training. © 2016. Published by The Company of Biologists Ltd.

Why does serotonergic activity drastically decrease during REM sleep?

PubMed

Sato, Kohji

2013-10-01

Here, I postulate two hypotheses that can explain the missing link between sleep and the serotonergic system in terms of spine homeostasis and memory consolidation. As dendritic spines contain many kinds of serotonin receptors, and the activation of serotonin receptors generally increases the number of spines in the cortex and hippocampus, I postulate that serotonin neurons are down-regulated during sleep to decrease spine number, which consequently maintains the total spine number at a constant level. Furthermore, since synaptic consolidation during REM sleep needs long-term potentiation (LTP), and serotonin is reported to inhibit LTP in the cortex, I postulate that serotonergic activity must drastically decrease during REM sleep to induce LTP and do memory consolidation. Until now, why serotonergic neurons show these dramatic changes in the sleep-wake cycle remains unexplained; however, making these hypotheses, I can confer physiological meanings on these dramatic changes of serotonergic neurons in terms of spine homeostasis and memory consolidation. Copyright © 2013. Published by Elsevier Ltd.

A Rural School/Community: A Case Study of a Dramatic Turnaround & Its Implications for School Improvement.

ERIC Educational Resources Information Center

Carlson, Robert V.

This paper presents a case study of a rural community exhibiting a dramatic turnaround in community support for a new school bond issue. Demographic change was partly responsible for the change in community attitudes, with two waves of immigration altering the long-term conservative orientation of this community. After a series of failed…

Cis-regulatory changes in Kit ligand expression and parallel evolution of pigmentation in sticklebacks and humans

PubMed Central

Miller, Craig T.; Beleza, Sandra; Pollen, Alex A.; Schluter, Dolph; Kittles, Rick A.; Shriver, Mark D.; Kingsley, David M.

2010-01-01

SUMMARY Dramatic pigmentation changes have evolved within most vertebrate groups, including fish and humans. Here we use genetic crosses in sticklebacks to investigate the parallel origin of pigmentation changes in natural populations. High-resolution mapping and expression experiments show that light gills and light ventrums map to a divergent regulatory allele of the Kit ligand (Kitlg) gene. The divergent allele reduces expression in gill and skin tissue, and is shared by multiple derived freshwater populations with reduced pigmentation. In humans, Europeans and East Asians also share derived alleles at the KITLG locus. Strong signatures of selection map to regulatory regions surrounding the gene, and admixture mapping shows that the KITLG genomic region has a significant effect on human skin color. These experiments suggest that regulatory changes in Kitlg contribute to natural variation in vertebrate pigmentation, and that similar genetic mechanisms may underlie rapid evolutionary change in fish and humans. PMID:18083106

Regional climatic warming drives long-term community changes of British marine fish.

PubMed Central

Genner, Martin J.; Sims, David W.; Wearmouth, Victoria J.; Southall, Emily J.; Southward, Alan J.; Henderson, Peter A.; Hawkins, Stephen J.

2004-01-01

Climatic change has been implicated as the cause of abundance fluctuations in marine fish populations worldwide, but the effects on whole communities are poorly understood. We examined the effects of regional climatic change on two fish assemblages using independent datasets from inshore marine (English Channel, 1913-2002) and estuarine environments (Bristol Channel, 1981-2001). Our results show that climatic change has had dramatic effects on community composition. Each assemblage contained a subset of dominant species whose abundances were strongly linked to annual mean sea-surface temperature. Species' latitudinal ranges were not good predictors of species-level responses, however, and the same species did not show congruent trends between sites. This suggests that within a region, populations of the same species may respond differently to climatic change, possibly owing to additional local environmental determinants, interspecific ecological interactions and dispersal capacity. This will make species-level responses difficult to predict within geographically differentiated communities. PMID:15156925

Altruism: A natural strategy for enhancing survival

NASA Astrophysics Data System (ADS)

Rozenfeld, Alejandro F.; Luis Gruver, José; Albano, Ezequiel V.; Havlin, Shlomo

2006-09-01

We study the influence of altruistic behavior in a prey-predator model permitting the preys to commit suicide by confronting the predators instead of escaping. Surprising, altruistic behavior at microscopic (local) scale, leads to the emergence of new complex macroscopic (global) phenomena characterized by dramatic changes in the dynamic topology of the prey-predator spatiotemporal distribution, yielding spiral patterns. We show that such dynamics enhances the prey's survivability.

Child Poverty in New Zealand: Why It Matters and How It Can Be Reduced

ERIC Educational Resources Information Center

Boston, Jonathan

2014-01-01

A combination of policy changes and wider socio-economic trends led to a dramatic increase in child poverty in New Zealand during the late 1980s and early 1990s. Higher rates of child poverty have now become embedded in the system and show little sign of resolving themselves. For a country which once took pride in being comparatively egalitarian…

"That School Had Become All about Show": Image Making and the Ironies of Constructing a Good Urban School

ERIC Educational Resources Information Center

Niesz, Tricia

2010-01-01

The last two decades have seen dramatic change in U.S. schooling as a response to high-stakes accountability and market-based reform movements. Critics cite a number of unfortunate consequences of these movements, especially for students in urban schools. This article explores the troubling ironies related to one strategy for survival in this…

Post-Little Landscape and Glacier Change in Glacier Bay National Park: Documenting More than a Century of Variability with Repeat Photography

NASA Astrophysics Data System (ADS)

Molnia, B. F.; Karpilo, R. D.; Pranger, H. S.

2004-12-01

Historical photographs, many dating from the late-19th century are being used to document landscape and glacier change in the Glacier Bay area. More than 350 pre-1980 photographs that show the Glacier Bay landscape and glacier termini positions have been acquired by the authors. Beginning in 2003, approximately 150 of the sites from which historical photographs had been made were revisited. At each site, elevation and latitude and longitude were recorded using WAAS-enabled GPS. Compass bearings to photographic targets were also determined. Finally, using the historical photographs as a composition guide, new photographs were exposed using digital imaging and film cameras. In the laboratory, 21st century images and photographs were compared with corresponding historical photographs to determine, and to better understand rates, timing, and mechanics of Glacier Bay landscape evolution, as well as to clarify the response of specific glaciers to changing climate and environment. The comparisons clearly document rapid vegetative succession throughout the bay; continued retreat of larger glaciers in the East Arm of the bay; a complex pattern of readvance and retreat of the larger glaciers in the West Arm of the bay, coupled with short-term fluctuations of its smaller glaciers; transitions from tidewater termini to stagnant, debris-covered termini; fiord sedimentation and erosion; development of outwash and talus features; and many other dramatic changes. As might be expected, 100-year-plus photo comparisons show significant changes throughout the Glacier Bay landscape, especially at the southern ends of East and West Arms. Surprisingly, recent changes, occurring since the late-1970s were equally dramatic, especially documenting the rapid thinning and retreat of glaciers in upper Muir Inlet.

Bark Beetle Impacts on Ecosystem Processes are Over Quickly and Muted Spatially

NASA Astrophysics Data System (ADS)

Ewers, B. E.; Norton, U.; Borkhuu, B.; Reed, D. E.; Peckham, S. D.; Biederman, J. A.; King, A.; Gochis, D. J.; Brooks, P. D.; Harpold, A. A.; Frank, J. M.; Massman, W. J.; Mackay, D. S.; Pendall, E. G.

2013-12-01

The recent epidemic of bark beetles across western North America has impacted conifers from low to high elevations from New Mexico to Yukon. The mechanism of mortality is clear, with both mountain pine and spruce beetles killing trees by introducing xylem occluding blue stain fungi which dramatically stops transpiration. The visual impact of this outbreak is stunning, with mortality of canopy trees over 90% in some stands. However, emerging work shows that the impact on ecosystem processes is not as dramatic. We hypothesize that increased soil water and nitrogen sets up rapid succession of plant communities, which quickly restores ecosystem processing of water, carbon and nitrogen, while spatial patchiness of mortality and belowground responses mutes the impact as spatial scale increases from stands to watersheds. In support of our hypothesis we found 1) Soil nitrogen and moisture increase within one growing season but decrease to the same as uninfested stands five years later. 2) Soil respiration is correlated with live tree basal area suggesting a large component of autotrophic respiration. 3) Once stands have more than 50% basal area mortality, seedling density increases up to five fold and total non-tree understory cover increased two fold both within five years after infestation. 4) Ecosystem scale estimates of water vapor fluxes do not decline as rapidly as overstory leaf area. 5) Stable isotopes of snow, soil and stream water suggest that increased below canopy evapotranspiration nearly compensates for reduced canopy transpiration. 6) Nested watershed data shows that precipitation variations are much more important in regulating streamflow than changes in canopies from bark beetle induced mortality. These results were tested in the Terrestrial Regional Ecosystem Exchange Simulator (TREES) model. TREES was able to predict annual changes in the carbon fluxes but had difficulty simulating soil moisture and annual water budgets likely due to inadequate abiotic water vapor flux mechanisms and an explicit understory canopy layer. Our results show that ecosystems are resilient to the bark beetle epidemic and the resulting ecosystem process change is much less dramatic than might be expected based on the visual impact.

Physiological correlates of symbiont migration during bleaching of two octocoral species.

PubMed

Netherton, Sarah E; Scheer, Daniele M; Morrison, Patrick R; Parrin, Austin P; Blackstone, Neil W

2014-05-01

Perturbed colonies of Phenganax parrini and Sarcothelia sp. exhibit migration of symbionts of Symbiodinium spp. into the stolons. Densitometry and visual inspection indicated that polyps bleached while stolons did not. When migration was triggered by temperature, light and confinement, colonies of Sarcothelia sp. decreased rates of oxygen formation in the light (due to the effects of perturbation on photosynthesis and respiration) and increased rates of oxygen uptake in the dark (due to the effects of perturbation on respiration alone). Colonies of P. parrini, by contrast, showed no significant changes in either aspect of oxygen metabolism. When migration was triggered by light and confinement, colonies of Sarcothelia sp. showed decreased rates of oxygen formation in the light and increased rates of oxygen uptake in the dark, while colonies of P. parrini maintained the former and increased the latter. During symbiont migration into their stolons, colonies of both species showed dramatic increases in reactive oxygen species (ROS), as visualized with a fluorescent probe, with stolons of Sarcothelia sp. exhibiting a nearly immediate increase of ROS. Differences in symbiont type may explain the greater sensitivity of colonies of Sarcothelia sp. Using fluorescent probes, direct measurements of migrating symbionts in the stolons of Sarcothelia sp. showed higher levels of reactive nitrogen species and lower levels of ROS than the surrounding host tissue. As measured by native fluorescence, levels of NAD(P)H in the stolons were unaffected by perturbation. Symbiont migration thus correlates with dramatic physiological changes and may serve as a marker for coral condition.

Patterns and Potential Drivers of Dramatic Changes in Tibetan Lakes, 1972–2010

PubMed Central

Li, Yingkui; Liao, Jingjuan; Guo, Huadong; Liu, Zewen; Shen, Guozhuang

2014-01-01

Most glaciers in the Himalayas and the Tibetan Plateau are retreating, and glacier melt has been emphasized as the dominant driver for recent lake expansions on the Tibetan Plateau. By investigating detailed changes in lake extents and levels across the Tibetan Plateau from Landsat/ICESat data, we found a pattern of dramatic lake changes from 1970 to 2010 (especially after 2000) with a southwest-northeast transition from shrinking, to stable, to rapidly expanding. This pattern is in distinct contrast to the spatial characteristics of glacier retreat, suggesting limited influence of glacier melt on lake dynamics. The plateau-wide pattern of lake change is related to precipitation variation and consistent with the pattern of permafrost degradation induced by rising temperature. More than 79% of lakes we observed on the central-northern plateau (with continuous permafrost) are rapidly expanding, even without glacial contributions, while lakes fed by retreating glaciers in southern regions (with isolated permafrost) are relatively stable or shrinking. Our study shows the limited role of glacier melt and highlights the potentially important contribution of permafrost degradation in predicting future water availability in this region, where understanding these processes is of critical importance to drinking water, agriculture, and hydropower supply of densely populated areas in South and East Asia. PMID:25372787

Patterns and potential drivers of dramatic changes in Tibetan lakes, 1972-2010.

PubMed

Li, Yingkui; Liao, Jingjuan; Guo, Huadong; Liu, Zewen; Shen, Guozhuang

2014-01-01

Most glaciers in the Himalayas and the Tibetan Plateau are retreating, and glacier melt has been emphasized as the dominant driver for recent lake expansions on the Tibetan Plateau. By investigating detailed changes in lake extents and levels across the Tibetan Plateau from Landsat/ICESat data, we found a pattern of dramatic lake changes from 1970 to 2010 (especially after 2000) with a southwest-northeast transition from shrinking, to stable, to rapidly expanding. This pattern is in distinct contrast to the spatial characteristics of glacier retreat, suggesting limited influence of glacier melt on lake dynamics. The plateau-wide pattern of lake change is related to precipitation variation and consistent with the pattern of permafrost degradation induced by rising temperature. More than 79% of lakes we observed on the central-northern plateau (with continuous permafrost) are rapidly expanding, even without glacial contributions, while lakes fed by retreating glaciers in southern regions (with isolated permafrost) are relatively stable or shrinking. Our study shows the limited role of glacier melt and highlights the potentially important contribution of permafrost degradation in predicting future water availability in this region, where understanding these processes is of critical importance to drinking water, agriculture, and hydropower supply of densely populated areas in South and East Asia.

Biocrusts in the context of global change

USGS Publications Warehouse

Reed, Sasha C.; Maestre, Fernando T.; Ochoa-Hueso, Raul; Kuske, Cheryl; Darrouzet-Nardi, Anthony N.; Darby, Brian; Sinsabaugh, Bob; Oliver, Mel; Sancho, Leo; Belnap, Jayne

2016-01-01

A wide range of studies show global environmental change will profoundly affect the structure, function, and dynamics of terrestrial ecosystems. The research synthesized here underscores that biocrust communities are also likely to respond significantly to global change drivers, with a large potential for modification to their abundance, composition, and function. We examine how elevated atmospheric CO2 concentrations, climate change (increased temperature and altered precipitation), and nitrogen deposition affect biocrusts and the ecosystems they inhabit. We integrate experimental and observational data, as well as physiological, community ecology, and biogeochemical perspectives. Taken together, these data highlight the potential for biocrust organisms to respond dramatically to environmental change and show how changes to biocrust community composition translate into effects on ecosystem function (e.g., carbon and nutrient cycling, soil stability, energy balance). Due to the importance of biocrusts in regulating dryland ecosystem processes and the potential for large modifications to biocrust communities, an improved understanding and predictive capacity regarding biocrust responses to environmental change are of scientific and societal relevance.

Phenylbutyrate inhibits homologous recombination induced by camptothecin and methyl methanesulfonate.

PubMed

Kaiser, Gitte S; Germann, Susanne M; Westergaard, Tine; Lisby, Michael

2011-08-01

Homologous recombination is accompanied by extensive changes to chromatin organization at the site of DNA damage. Some of these changes are mediated through acetylation/deacetylation of histones. Here, we show that recombinational repair of DNA damage induced by the anti-cancer drug camptothecin (CPT) and the alkylating agent methyl methanesulfonate (MMS) is blocked by sodium phenylbutyrate (PBA) in the budding yeast Saccharomyces cerevisiae. In particular, PBA suppresses CPT- and MMS-induced genetic recombination as well as DNA double-strand break repair during mating-type interconversion. Treatment with PBA is accompanied by a dramatic reduction in histone H4 lysine 8 acetylation. Live cell imaging of homologous recombination proteins indicates that repair of CPT-induced DNA damage is redirected to a non-recombinogenic pathway in the presence of PBA without loss in cell viability. In contrast, the suppression of MMS-induced recombination by PBA is accompanied by a dramatic loss in cell viability. Taken together, our results demonstrate that PBA inhibits DNA damage-induced homologous recombination likely by mediating changes in chromatin acetylation. Moreover, the combination of PBA with genotoxic agents can lead to different cell fates depending on the type of DNA damage inflicted. 2011 Elsevier B.V. All rights reserved.

Drug Delivery for Peripheral Nerve Regeneration

DTIC Science & Technology

2014-09-01

1. Introduction 4 2. Keywords 4 3. Accomplishments 4 4. Impact 15 5. Changes/Problems 16 6. Products 17 7. Participants & Other... enzymatically and under adverse pH levels • Diffusion dropped dramatically after 6 days Figure 8 shows that the diffusion rate is independent of loaded...efficacy of the device using in-vitro and DRG studies. This data will help researchers/ industry to further develop drug delivery efforts in other areas

Rapid Vegetational Change in Coastal North America: The Response to Climate Since the LGM

NASA Technical Reports Server (NTRS)

Peteet, Dorothy; Kneller, Margaret

1999-01-01

The late-glacial interval provided rapid shifts in climate which are mirrored by dramatic vegetational changes in North America. Through a transect of lake and mire sites from Connecticut to Virginia on the east coast and Kodiak Island on the western coast, we trace the warming following the LGM with the response of forests and tundra. A brief cold reversal in Virginia is seen from 12,260 to 12,200. The subsequent longer and extreme Younger Dryas event is marked in the southern New England - New Jersey region by dramatic boreal and deciduous forest changes. In the southeastern US, forests also change rapidly, with hemlock forest expansion suggesting increased moisture. In Kodiak Island, the warm, moist tundra of the Bolling/Allerod is replaced by colder, windswept Empetrum-dominated tundra during the Younger Dryas. The Pleistocene/Holocene shift in vegetation is remarkably pronounced in eastern North America as well as the Alaskan coastline. Response time of vegetation to climate change appears to be on the order of decades throughout these coastal locations, probably because of the proximity of sites to important ecotonal boundaries, and the magnitude of the events. Even in Virginia's Holocene record, a cold reversal inferred from increases in spruce and fir is noted at 7500 C14 yr BP. This response of the forests to a short-lived cooling shows the sensitivity of the biosphere to a rapid climate shifts.

Dramatic colour changes in a bird of paradise caused by uniquely structured breast feather barbules.

PubMed

Stavenga, Doekele G; Leertouwer, Hein L; Marshall, N Justin; Osorio, Daniel

2011-07-22

The breast-plate plumage of male Lawes' parotia (Parotia lawesii) produces dramatic colour changes when this bird of paradise displays on its forest-floor lek. We show that this effect is achieved not solely by the iridescence--that is an angular-dependent spectral shift of the reflected light--which is inherent in structural coloration, but is based on a unique anatomical modification of the breast-feather barbule. The barbules have a segmental structure, and in common with many other iridescent feathers, they contain stacked melanin rodlets surrounded by a keratin film. The unique property of the parotia barbules is their boomerang-like cross section. This allows each barbule to work as three coloured mirrors: a yellow-orange reflector in the plane of the feather, and two symmetrically positioned bluish reflectors at respective angles of about 30°. Movement during the parotia's courtship displays thereby achieves much larger and more abrupt colour changes than is possible with ordinary iridescent plumage. To our knowledge, this is the first example of multiple thin film or multi-layer reflectors incorporated in a single structure (engineered or biological). It nicely illustrates how subtle modification of the basic feather structure can achieve novel visual effects. The fact that the parotia's breast feathers seem to be specifically adapted to give much stronger colour changes than normal structural coloration implies that colour change is important in their courtship display.

Abrupt increase in rat carotid blood flow induces rapid alteration of artery mechanical properties

PubMed Central

Monson, Kenneth L.; Matsumoto, Melissa M.; Young, William L.; Manley, Geoffrey T.; Hashimoto, Tomoki

2010-01-01

Vascular remodeling is essential to proper vessel function. Dramatic changes in mechanical environment, however, may initiate pathophysiological vascular remodeling processes that lead to vascular disease. Previous work by some of our group has demonstrated a dramatic rise in matrix metalloproteinase (MMP) expression shortly following an abrupt increase in carotid blood flow. We hypothesized that there would be a corresponding change in carotid mechanical properties. Unilateral carotid ligation surgery was performed to produce an abrupt, sustained increase in blood flow through the contralateral carotid artery of rats. The flow-augmented artery was harvested after sham surgery or 1, 2, or 6 days after flow augmentation. Vessel mechanical response in the circumferential direction was then evaluated through a series of pressure-diameter tests. Results show that the extent of circumferential stretch (normalized change in diameter) at in vivo pressure levels was significantly different (p<0.05) from normo-flow controls at 1 and 2 days following flow augmentation. Measurements at 1, 2, and 6 days were not significantly different from one another, but a trend in the data suggested that circumferential stretch was largest 1 day following surgery and subsequently decreased toward baseline values. Because previous work with this model indicated a similar temporal pattern for MMP-9 expression, an exploratory set of experiments was conducted where vessels were tested 1 day following surgery in animals treated with broad spectrum MMP inhibitors (either doxycycline or GM6001). Results showed a trend for the inhibitors to minimize changes in mechanical properties. Observations demonstrate that vessel mechanical properties change rapidly following flow augmentation and that alterations may be linked to expression of MMPs. PMID:21094476

Using Immersion to teach Global Climate Change

NASA Astrophysics Data System (ADS)

Sumners, C. T.; Handron, K.; Reiff, P. H.; Law, C. C.

2004-12-01

Students are increasingly jaded to programs that preach, and museums are increasingly finding it difficult to attract students who can retrieve information quickly from the internet or cable TV. A new medium of immersive theater can now engulf the viewer in the subject, bringing a novel view to the exciting new data sets and images now available. By telling a compelling story with characters they can identify with, global climate change can be experienced and its effects brought home in a dramatic and effective way. We have developed several shows highlighting climate change (Powers of Time, Secrets of the Dead Sea), and are developing new shows (Earth's Wild Ride, Earth in the Balance) which can be used to take the visitor into the past or into the future. Clips from the shows and evidence of their effectiveness as an educational tool for Earth science will be shown. If possible, our new portable dome system will be set up in the poster hall for longer live demos of our shows.

Nucleation and atomic layer reaction in nickel silicide for defect-engineered Si nanochannels.

PubMed

Tang, Wei; Picraux, S Tom; Huang, Jian Yu; Gusak, Andriy M; Tu, King-Ning; Dayeh, Shadi A

2013-06-12

At the nanoscale, defects can significantly impact phase transformation processes and change materials properties. The material nickel silicide has been the industry standard electrical contact of silicon microelectronics for decades and is a rich platform for scientific innovation at the conjunction of materials and electronics. Its formation in nanoscale silicon devices that employ high levels of strain, intentional, and unintentional twins or grain boundaries can be dramatically different from the commonly conceived bulk processes. Here, using in situ high-resolution transmission electron microscopy (HRTEM), we capture single events during heterogeneous nucleation and atomic layer reaction of nickel silicide at various crystalline boundaries in Si nanochannels for the first time. We show through systematic experiments and analytical modeling that unlike other typical face-centered cubic materials such as copper or silicon the twin defects in NiSi2 have high interfacial energies. We observe that these twin defects dramatically change the behavior of new phase nucleation and can have direct implications for ultrascaled devices that are prone to defects or may utilize them to improve device performance.

Evolution of the P/Shoemaker-Levy 9 Gang

NASA Image and Video Library

1998-05-02

This series of eight NASA Hubble Space Telescope "snapshots" shows the evolution of the P-Q complex, also called the "gang of four" region, of comet P/Shoemaker-Levy 9. The eight individual frames chronicle changes in the comet during the 12 months before colliding with Jupiter. The sequence shows that the relative separations of the various cometary fragments, thought to range in size from about 500 meters to almost 4 km (2.5 miles) across, changed dramatically over this period. The apparent separation of Q1 and Q2 was only about 1100 kilometers (680 miles) on 1 July 1993 and increased to 28,000 kilometers (17,400 miles) by 20 July 1994. http://photojournal.jpl.nasa.gov/catalog/PIA01264

Beneficial microbes affect endogenous mechanisms controlling root development

PubMed Central

Verbon, Eline H.; Liberman, Louisa M.

2016-01-01

Plants have incredible developmental plasticity, enabling them to respond to a wide range of environmental conditions. Among these conditions is the presence of plant growth-promoting rhizobacteria (PGPR) in the soil. Recent studies show that PGPR affect root growth and development within Arabidopsis thaliana root. These effects lead to dramatic changes in root system architecture, that significantly impact aboveground plant growth. Thus, PGPR may promote shoot growth via their effect on root developmental programs. This review focuses on contextualizing root developmental changes elicited by PGPR in light of our understanding of plant-microbe interactions and root developmental biology. PMID:26875056

Medicare payment changes and nursing home quality: effects on long-stay residents.

PubMed

Konetzka, R Tamara; Norton, Edward C; Stearns, Sally C

2006-09-01

The Balanced Budget Act of 1997 dramatically changed the way that Medicare pays skilled nursing facilities, providing a natural experiment in nursing home behavior. Medicare payment policy (directed at short-stay residents) may have affected outcomes for long-stay, chronic-care residents if services for these residents were subsidized through cost-shifting prior to implementation of Medicare prospective payment for nursing homes. We link changes in both the form and level of Medicare payment at the facility level with changes in resident-level quality, as represented by pressure sores and urinary tract infections in Minimum Data Set (MDS) assessments. Results show that long-stay residents experienced increased adverse outcomes with the elimination of Medicare cost reimbursement.

Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively

PubMed Central

Orriss, George L.; Niland, Stephan; Johanningmeier, Benjamin; Pohlentz, Gottfried; Meier, Markus; Karrasch, Simone; Estevão-Costa, Maria Inacia; Martins Lima, Augusto; Stetefeld, Jörg

2017-01-01

The collagen binding integrin α2β1 plays a crucial role in hemostasis, fibrosis, and cancer progression amongst others. It is specifically inhibited by rhodocetin (RC), a C-type lectin-related protein (CLRP) found in Malayan pit viper (Calloselasma rhodostoma) venom. The structure of RC alone reveals a heterotetramer arranged as an αβ and γδ subunit in a cruciform shape. RC specifically binds to the collagen binding A-domain of the integrin α2 subunit, thereby blocking collagen-induced platelet aggregation. However, until now, the molecular basis for this interaction has remained unclear. Here, we present the molecular structure of the RCγδ-α2A complex solved to 3.0 Å resolution. Our findings show that RC undergoes a dramatic structural reorganization upon binding to α2β1 integrin. Besides the release of the nonbinding RCαβ tandem, the RCγ subunit interacts with loop 2 of the α2A domain as result of a dramatic conformational change. The RCδ subunit contacts the integrin α2A domain in the “closed” conformation through its helix C. Combined with epitope-mapped antibodies, conformationally locked α2A domain mutants, point mutations within the α2A loop 2, and chemical modifications of the purified toxin protein, this molecular structure of RCγδ-α2A complex explains the inhibitory mechanism and specificity of RC for α2β1 integrin. PMID:28704364

Suppression of turbulent particle flux during biased rotation in LAPD

NASA Astrophysics Data System (ADS)

Carter, T. A.

2005-10-01

The edge plasma in LAPD is rotated through the application of a bias voltage (typically 100V-200V) between the plasma source cathode and the vacuum vessel wall. Without bias, cross-field turbulent particle transport causes the density profile to extend well past the cathode edge, with a fairly gentle gradient (Ln˜10 cm). As the bias voltage is applied and increased past a threshold value, the measured density profile steepens dramatically (Ln˜2 cm) at a radius near the peak of the flow shear. Turbulent transport flux measurements in this region show that the flux is reduced and then suppressed completely as the threshold is approached. As the bias voltage is increased further, the measured turbulent transport flux reverses direction. The amplitude of the density and azimuthal electric field fluctuations is observed to decrease during biased rotation, the product of the amplitudes decreasing by a factor of 5. However the dominant change appears in the cross-phase, which is altered dramatically, leading to the observed suppression and reversal of the turbulent flux. Detailed two-dimensional turbulent correlation measurements have been performed using the high repetition rate (1 Hz) and high reproducibility of LAPD plasmas. In unbiased plasmas, the correlation is localized to around 5 cm radially and a slightly smaller distance azimuthally (ρs˜0.5-1 cm). During biased rotation, a dramatic increase in the azimuthal correlation is observed, however there is little change in the radial correlation length.

LANGUAGE DEVELOPMENT. The developmental dynamics of marmoset monkey vocal production.

PubMed

Takahashi, D Y; Fenley, A R; Teramoto, Y; Narayanan, D Z; Borjon, J I; Holmes, P; Ghazanfar, A A

2015-08-14

Human vocal development occurs through two parallel interactive processes that transform infant cries into more mature vocalizations, such as cooing sounds and babbling. First, natural categories of sounds change as the vocal apparatus matures. Second, parental vocal feedback sensitizes infants to certain features of those sounds, and the sounds are modified accordingly. Paradoxically, our closest living ancestors, nonhuman primates, are thought to undergo few or no production-related acoustic changes during development, and any such changes are thought to be impervious to social feedback. Using early and dense sampling, quantitative tracking of acoustic changes, and biomechanical modeling, we showed that vocalizations in infant marmoset monkeys undergo dramatic changes that cannot be solely attributed to simple consequences of growth. Using parental interaction experiments, we found that contingent parental feedback influences the rate of vocal development. These findings overturn decades-old ideas about primate vocalizations and show that marmoset monkeys are a compelling model system for early vocal development in humans. Copyright © 2015, American Association for the Advancement of Science.

A unique coral biomineralization pattern has resisted 40 million years of major ocean chemistry change

NASA Astrophysics Data System (ADS)

Stolarski, Jarosław; Bosellini, Francesca R.; Wallace, Carden C.; Gothmann, Anne M.; Mazur, Maciej; Domart-Coulon, Isabelle; Gutner-Hoch, Eldad; Neuser, Rolf D.; Levy, Oren; Shemesh, Aldo; Meibom, Anders

2016-06-01

Today coral reefs are threatened by changes to seawater conditions associated with rapid anthropogenic global climate change. Yet, since the Cenozoic, these organisms have experienced major fluctuations in atmospheric CO2 levels (from greenhouse conditions of high pCO2 in the Eocene to low pCO2 ice-house conditions in the Oligocene-Miocene) and a dramatically changing ocean Mg/Ca ratio. Here we show that the most diverse, widespread, and abundant reef-building coral genus Acropora (20 morphological groups and 150 living species) has not only survived these environmental changes, but has maintained its distinct skeletal biomineralization pattern for at least 40 My: Well-preserved fossil Acropora skeletons from the Eocene, Oligocene, and Miocene show ultra-structures indistinguishable from those of extant representatives of the genus and their aragonitic skeleton Mg/Ca ratios trace the inferred ocean Mg/Ca ratio precisely since the Eocene. Therefore, among marine biogenic carbonate fossils, well-preserved acroporid skeletons represent material with very high potential for reconstruction of ancient ocean chemistry.

Seismic detection of increased degassing before Kīlauea's 2008 summit explosion.

PubMed

Johnson, Jessica H; Poland, Michael P

2013-01-01

The 2008 explosion that started a new eruption at the summit of Kīlauea Volcano, Hawai'i, was not preceded by a dramatic increase in earthquakes nor inflation, but was associated with increases in SO2 emissions and seismic tremor. Here we perform shear wave splitting analysis on local earthquakes spanning the onset of the eruption. Shear wave splitting measures seismic anisotropy and is traditionally used to infer changes in crustal stress over time. We show that shear wave splitting may also vary due to changes in volcanic degassing. The orientation of fast shear waves at Kīlauea is usually controlled by structure, but in 2008 showed changes with increased SO2 emissions preceding the start of the summit eruption. This interpretation for changing anisotropy is supported by corresponding decreases in Vp/Vs ratio. Our result demonstrates a novel method for detecting changes in gas flux using seismic observations and provides a new tool for monitoring under-instrumented volcanoes.

Seismic detection of increased degassing before Kīlauea's 2008 summit explosion

USGS Publications Warehouse

Johnson, Jessica H.; Poland, Michael P.

2013-01-01

The 2008 explosion that started a new eruption at the summit of Kīlauea Volcano, Hawai‘i, was not preceded by a dramatic increase in earthquakes nor inflation, but was associated with increases in SO2 emissions and seismic tremor. Here we perform shear wave splitting analysis on local earthquakes spanning the onset of the eruption. Shear wave splitting measures seismic anisotropy and is traditionally used to infer changes in crustal stress over time. We show that shear wave splitting may also vary due to changes in volcanic degassing. The orientation of fast shear waves at Kīlauea is usually controlled by structure, but in 2008 showed changes with increased SO2 emissions preceding the start of the summit eruption. This interpretation for changing anisotropy is supported by corresponding decreases in Vp/Vs ratio. Our result demonstrates a novel method for detecting changes in gas flux using seismic observations and provides a new tool for monitoring under-instrumented volcanoes.

Fifty-Year Record of Glacier Change Reveals Shifting Climate in the Pacific Northwest and Alaska, USA

USGS Publications Warehouse

,

2009-01-01

Fifty years of U.S. Geological Survey (USGS) research on glacier change shows recent dramatic shrinkage of glaciers in three climatic regions of the United States. These long periods of record provide clues to the climate shifts that may be driving glacier change. The USGS Benchmark Glacier Program began in 1957 as a result of research efforts during the International Geophysical Year (Meier and others, 1971). Annual data collection occurs at three glaciers that represent three climatic regions in the United States: South Cascade Glacier in the Cascade Mountains of Washington State; Wolverine Glacier on the Kenai Peninsula near Anchorage, Alaska; and Gulkana Glacier in the interior of Alaska (fig. 1).

Global Warming in the 21st Century: An Alternate Scenario

NASA Technical Reports Server (NTRS)

Hansen, James E.

2000-01-01

Evidence on a broad range of time scales, from Proterozoic to the most recent periods, shows that the Earth's climate responds sensitively to global forcings. In the past few decades the Earth's surface has warmed rapidly, apparently in response to increasing anthropogenic greenhouse gases in the atmosphere. The conventional view is that the current global warming rate will continue or accelerate in the 21st century. I will describe an alternate scenario that would slow the rate of global warming and reduce the danger of dramatic climate change. But reliable prediction of future climate change requires improved knowledge of the carbon cycle and global observations that allow interpretation of ongoing climate change.

The Need for Speed: Neuroendocrine Regulation of Socially-controlled Sex Change.

PubMed

Lamm, Melissa S; Liu, Hui; Gemmell, Neil J; Godwin, John R

2015-08-01

Socially-controlled functional sex change in fishes is a dramatic example of adaptive reproductive plasticity. Functional gonadal sex change can occur within a week while behavioral sex change can begin within minutes. Significant progress has been made in understanding the neuroendocrine bases of this phenomenon at both the gonadal and the neurobiological levels, but a detailed mechanistic understanding remains elusive. We are working with sex-changing wrasses to identify evolutionarily-conserved neuroendocrine pathways underlying this reproductive adaptation. One key model is the bluehead wrasse (Thalassoma bifasciatum), in which sex change is well studied at the behavioral, ecological, and neuroendocrine levels. Bluehead wrasses show rapid increases in aggressive and courtship behaviors with sex change that do not depend on the presence of gonads. The display of male-typical behavior is correlated with the expression of arginine vasotocin, and experiments support a role for this neuropeptide. Estrogen synthesis is also critical in the process. Female bluehead wrasses have higher abundance of aromatase mRNA in the brain and gonads, and estrogen implants block behavioral sex change. While established methods have advanced our understanding of sex change, a full understanding will require new approaches and perspectives. First, contributions of other neuroendocrine systems should be better characterized, particularly glucocorticoid and thyroid signaling. Second, advances in genomics for non-traditional model species should allow conserved mechanisms to be identified with a key next-step being manipulative tests of these mechanisms. Finally, advances in genomics now also allow study of the role of epigenetic modifications and other regulatory mechanisms in the dramatic alterations across the sex-change process. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Psychosocial aspects of women's lives: work, family, and life cycle issues.

PubMed

Shrier, Diane K

2003-09-01

Over the past century and continuing to evolve into the twenty-first century, there have been dramatic changes in work and personal/family lives within the United States. These changes, though strongly affecting men and children, have impacted most dramatically on women's lives, particularly white, middle-class women. Psychiatrists and other mental health clinicians need to be aware of the scope and nature of these changes and to recognize that their own personal experiences and values might differ from those of women of different generations as well as different socioeconomic and cultural backgrounds.

The Inevitability of Ethnocentrism Revisited: Ethnocentrism Diminishes As Mobility Increases.

PubMed

De, Soham; Gelfand, Michele J; Nau, Dana; Roos, Patrick

2015-12-08

Nearly all major conflicts across the globe, both current and historical, are characterized by individuals defining themselves and others by group membership. This existence of group-biased behavior (in-group favoring and out-group hostile) has been well established empirically, and has been shown to be an inevitable outcome in many evolutionary studies. Thus it is puzzling that statistics show violence and out-group conflict declining dramatically over the past few centuries of human civilization. Using evolutionary game-theoretic models, we solve this puzzle by showing for the first time that out-group hostility is dramatically reduced by mobility. Technological and societal advances over the past centuries have greatly increased the degree to which humans change physical locations, and our results show that in highly mobile societies, one's choice of action is more likely to depend on what individual one is interacting with, rather than the group to which the individual belongs. Our empirical analysis of archival data verifies that contexts with high residential mobility indeed have less out-group hostility than those with low mobility. This work suggests that, in fact, group-biased behavior that discriminates against out-groups is not inevitable after all.

The Inevitability of Ethnocentrism Revisited: Ethnocentrism Diminishes As Mobility Increases

PubMed Central

De, Soham; Gelfand, Michele J.; Nau, Dana; Roos, Patrick

2015-01-01

Nearly all major conflicts across the globe, both current and historical, are characterized by individuals defining themselves and others by group membership. This existence of group-biased behavior (in-group favoring and out-group hostile) has been well established empirically, and has been shown to be an inevitable outcome in many evolutionary studies. Thus it is puzzling that statistics show violence and out-group conflict declining dramatically over the past few centuries of human civilization. Using evolutionary game-theoretic models, we solve this puzzle by showing for the first time that out-group hostility is dramatically reduced by mobility. Technological and societal advances over the past centuries have greatly increased the degree to which humans change physical locations, and our results show that in highly mobile societies, one’s choice of action is more likely to depend on what individual one is interacting with, rather than the group to which the individual belongs. Our empirical analysis of archival data verifies that contexts with high residential mobility indeed have less out-group hostility than those with low mobility. This work suggests that, in fact, group-biased behavior that discriminates against out-groups is not inevitable after all. PMID:26644192

Land use/land cover change and their effects on landscape patterns in the Yanqi Basin, Xinjiang (China).

PubMed

Wang, Shuixian; Wang, Shengli

2013-12-01

Human modification of land use and land cover change (LUCC) drives the change of landscape patterns and limits the availability of products and services for human and livestock. LUCC can undermine environmental health. Thus, this study aimed to develop an understanding of LUCC in the Yanqi Basin, Xinjiang, China, an arid area experiencing dramatic water and land resource use. A time series of satellite images (1964, 1973, 1989, 1999, and 2009) were used to calculate the index of landscape patterns to study the processes involved in changes to land uses and landscape patterns and the influence of this changes on landscape patterns. The results show that land uses in the Yanqi Basin have changed dramatically since 1964 with grassland being mainly converted to cropland. Landscape fragmentation and diversity have decreased in the study area, although landscape fragmentation increased from 1964 to 1999 and then decreased by 2009. The index of landscape diversity decreased from 1.64 in 1964 to 0.71 in 2009. The heterogeneity and complexity of the landscape increased during this period. In contrast, the index of dominance decreased from 0.85 in 1964 to 0.83 in 2009. Land use change drives landscape patterns of the development of the watershed toward diversity and a fragmented structure. Population growth, economic development, and industrial policies were the dominant driving forces behind LUCC in the Yanqi Basin. Sustainable use of land resources is a significant factor in maintaining economic development and environmental protection in this arid inland river basin.

Higher Education Affordability: Two Approaches

ERIC Educational Resources Information Center

DiSalvo, Steven R.

2017-01-01

There are two initiatives that can dramatically change the way college pricing and student debt are being handled under the current system. Both are commonsense solutions that would, if accepted, dramatically help students, graduates and families burdened by the cost of tuition and the loans they take to earn their degrees. First, income-based…

The health care industry: in evolution or revolution?

PubMed

Cleverley, W O

1999-01-01

The health care industry has experienced dramatic changes during the last 25 years and will likely undergo even more dramatic changes in the next 25 years. Many firms in the health care industry will thrive just as many firms have thrived during the last 25 years. The ultimate key to success will be management and their attention to the basics of good business management. Management has always been the key ingredient and will continue to be the most critical success factor.

Preliminarily Assessment of Long-term Cloud Top Heights in Central Taiwan

NASA Astrophysics Data System (ADS)

Lai, Y. J.; Po-Hsiung, L.

2015-12-01

The Xitou region, as the epitome of mid-elevation forest ecosystem and known as a famous forest recreation area in Taiwan. Although two disasters, "921 earthquake" in 1999 and typhoon Toraji in 2001, heavily hit this area and cause a significant reduction in visitors from 1 to about 0.4 million per year, the tourists have returned after the reconstruction in 2003 and approached 1.5 million high since 2010. The high quantity of tourists obviously drives the development of tourism industry which, unfortunately, increases the local sources of heating. A preliminarily analysis showed the warming rate was 0.29 oC/decade for June 2005 to May 2013 while from the 1940s to the 1980s, it was only 0.1 oC/decade. The warming pattern in Xitou region is similar to the global warming situation that a more dramatic trend happened during the past 10 years. The change of land use, which derived from the pressure of tourism industry, might accelerate regional climate warming. For the purpose of understanding cloud response to anthropogenic forcing, the long-term 1-km spatial resolution cloud top heights (cth) data sets (collection 6) from the Moderate Resolution Imaging Spectroradiometer (MODIS) were assessed. The results showed the annual cloud event amounts of the Terra and Aqua changed insignificantly since 2003 disregard of the cth. However, the cloud fraction of the cth less than 2000m was 18% in 2003 and dropped dramatically to 7% since 2011. Correspondingly, the cth between 2000m to 4000m was increased from 35% in 2003 to 45% in 2014. Further analysis the nighttime events indicated similar pattern but only 6% different between 2003 and 2014. The Aqua daytime events showed a more dramatic fraction anomaly which was decreased 18% at the cth less than 2000m and increased 18% at the cth between 2000m to 4000m. This preliminary assessment represents the cloud is pushing higher which might be caused by the anthropogenic forcing during the last decade. However, this study also found that the cth data sets were sensitive to the upgrade of inversion model and satellite calibration in 2010 which might also be another important consideration. A total solution of integrating ceilometer, ground lidar, spaceborne lidar and UAV profile observations for monitoring/understanding the characteristics of Xitou microclimate change are still on-going.

Morphological changes and fusogenic activity of influenza virus hemagglutinin.

PubMed Central

Shangguan, T; Siegel, D P; Lear, J D; Axelsen, P H; Alford, D; Bentz, J

1998-01-01

The kinetics of low-pH induced fusion of influenza virus with liposomes have been compared to changes in the morphology of influenza hemagglutinin (HA). At pH 4.9 and 30 degrees C, the fusion of influenza A/PR/8/34 virus with ganglioside-bearing liposomes was complete within 6 min. Virus preincubated at pH 4.9 and 30 degrees C in the absence of liposomes for 2 or 10 min retained most of its fusion activity. However, fusion activity was dramatically reduced after 30 min, and virtually abolished after a 60-min preincubation. Cryo-electron microscopy showed that the hemagglutinin spikes of virions exposed to pH 4.9 at 30 degrees C for 10 min underwent no major morphological changes. After 30 min, however, the spike morphology changed dramatically, and further changes occurred for up to 60 min after exposure to low pH. Because the morphological changes occur at a rate corresponding to the loss of fusion activity, and because these changes are much slower than the rate at which fusion occurs, we conclude that the morphologically altered HA is inactive with respect to fusion-promoting activity. Molecular modeling studies indicate that the formation of an extended coiled coil within the HA trimer, as proposed for HA at low pH, requires a major conformational change in HA, and that the morphological changes we observe are consistent with the formation of an extended coiled coil. These results imply that the crystallographically determined low-pH form of HA does occur in the intact virus, but that this form is not a precursor of viral fusion. It is speculated that the motion to the low-pH form may be responsible for the membrane destabilization leading to fusion. PMID:9449309

Dramatic colour changes in a bird of paradise caused by uniquely structured breast feather barbules

PubMed Central

Stavenga, Doekele G.; Leertouwer, Hein L.; Marshall, N. Justin; Osorio, Daniel

2011-01-01

The breast-plate plumage of male Lawes' parotia (Parotia lawesii) produces dramatic colour changes when this bird of paradise displays on its forest-floor lek. We show that this effect is achieved not solely by the iridescence—that is an angular-dependent spectral shift of the reflected light—which is inherent in structural coloration, but is based on a unique anatomical modification of the breast-feather barbule. The barbules have a segmental structure, and in common with many other iridescent feathers, they contain stacked melanin rodlets surrounded by a keratin film. The unique property of the parotia barbules is their boomerang-like cross section. This allows each barbule to work as three coloured mirrors: a yellow-orange reflector in the plane of the feather, and two symmetrically positioned bluish reflectors at respective angles of about 30°. Movement during the parotia's courtship displays thereby achieves much larger and more abrupt colour changes than is possible with ordinary iridescent plumage. To our knowledge, this is the first example of multiple thin film or multi-layer reflectors incorporated in a single structure (engineered or biological). It nicely illustrates how subtle modification of the basic feather structure can achieve novel visual effects. The fact that the parotia's breast feathers seem to be specifically adapted to give much stronger colour changes than normal structural coloration implies that colour change is important in their courtship display. PMID:21159676

The International Arctic Buoy Programme (IABP)

NASA Astrophysics Data System (ADS)

Rigor, I. G.; Ortmeyer, M.

2003-12-01

The Arctic has undergone dramatic changes in weather, climate and environment. It should be noted that many of these changes were first observed and studied using data from the International Arctic Buoy Programme (IABP). For example, IABP data were fundamental to Walsh et al. (1996) showing that atmospheric pressure has decreased, Rigor et al. (2000) showing that air temperatures have increased, and to Proshutinsky and Johnson (1997); Steele and Boyd, (1998); Kwok, (2000); and Rigor et al. (2002) showing that the clockwise circulation of sea ice and the ocean has weakened. All these results relied heavily on data from the IABP. In addition to supporting these studies of climate change, the IABP observations are also used to forecast weather and ice conditions, validate satellite retrievals of environmental variables, to force, validate and initialize numerical models. Over 350 papers have been written using data from the IABP. The observations and datasets of the IABP data are one of the cornerstones for environmental forecasting and research in the Arctic.

Enhancement mechanisms of short-time aerobic digestion for waste activated sludge in the presence of cocoamidopropyl betaine.

PubMed

Xia, Siqing; Zhou, Yun; Eustance, Everett; Zhang, Zhiqiang

2017-10-18

Cocoamidopropyl betaine (CAPB), which is a biodegradable ampholytic surfactant, has recently been found to dramatically enhance the aerobic digestion of waste activated sludge (WAS) in short-time aerobic digestion (STAD) systems. Therefore, it is important to understand the mechanisms in which CAPB enhances WAS aerobic digestion performance. Results showed that CAPB could dramatically enhance the solubilization of soluble proteins (PN), polysaccharides (PS), nucleic acids (NA) and humic-like substances (HS) in the STAD system within the initial 2 h. Then PN, PS and NA gradually decreased, while HS showed only minor decease. In addition, CAPB increased the proportion of low MW fractions (<20 kDa) from 4.22% to 39.4%, which are more biodegradable. Specific oxygen uptake rates and dehydrogenase enzyme activity results indicated that CAPB markedly improved the aerobic microorganism activities. Microbial community analyses and principle coordinate analyses (PCoA) revealed that CAPB increased the proportion of some functional microorganisms, including Proteobacteria, Planctomycetales, Acinetobacter, Pseudomonas and Aeromonas. The changes driven by CAPB could explain the enhanced performance of the STAD system for WAS aerobic treatment.

Is Acute Myocardial Infarction Disappearing?

PubMed Central

Luepker, Russell V.; Berger, Alan K.

2017-01-01

Following a peak in the mid 1960s, there has been a steady decline in coronary heart disease (CHD) mortality in the United States of 2.8%/y to 5.1%/y.1,2 This shift in mortality patterns is most dramatic in the age-adjusted rates. Age adjustment compensates for the transition of CHD in older age groups and the increase in the aged population. The absolute number of total CHD deaths showed little change until recently (Figure 1). Life expectancy of adults dramatically increased, largely as a result of these improved CHD outcomes.3 However, the reduction in mortality was not associated with a decline in hospital morbidity as CHD was pushed into the older age groups.1 Prevalence actually increased with more individuals diagnosed, treated, and surviving.1 CHD hospitalizations for those >65 years of age increased from 1965 to 2000 while declining in younger age groups.1 PMID:20212286

The influence of the loop between residues 223-235 in beetle luciferase bioluminescence spectra: a solvent gate for the active site of pH-sensitive luciferases.

PubMed

Viviani, Vadim R; Silva Neto, Antonio J; Arnoldi, Frederico G C; Barbosa, João A R G; Ohmiya, Yoshihiro

2008-01-01

Beetle luciferases emit a wide range of bioluminescence colors, ranging from green to red. Firefly luciferases can shift the spectrum to red in response to pH and temperature changes, whereas click beetle and railroadworm luciferases do not. Despite many studies on firefly luciferases, the origin of pH-sensitivity is far from being understood. Through comparative site-directed mutagenesis and modeling studies, using the pH-sensitive luciferases (Macrolampis and Cratomorphus distinctus fireflies) and the pH-insensitive luciferases (Pyrearinus termitilluminans, Phrixotrix viviani and Phrixotrix hirtus) cloned by our group, here we show that substitutions dramatically affecting bioluminescence colors in both groups of luciferases are clustered in the loop between residues 223-235 (Photinus pyralis sequence). The substitutions at positions 227, 228 and 229 (P. pyralis sequence) cause dramatic redshift and temporal shift in both groups of luciferases, indicating their involvement in labile interactions. Modeling studies showed that the residues Y227 and N229 are buried in the protein core, fixing the loop to other structural elements participating at the bottom of the luciferin binding site. Changes in pH and temperature (in firefly luciferases), as well as point mutations in this loop, may disrupt the interactions of these structural elements exposing the active site and modulating bioluminescence colors.

Io - Full Disk Centered on Media Regio

NASA Technical Reports Server (NTRS)

1996-01-01

The mottled face of Jupiter's volcanically active moon Io [pronounced 'EYE-oh' or 'EE-OH'], viewed by the camera onboard NASA's Galileo spacecraft, shows dramatic changes since it was seen 17 years ago by the exploratory NASA spacecraft Voyagers 1 and 2. This Galileo image, taken on June 25, 1996 at a range of 2.24 million kilometers (1.4 million miles), is centered on the Media Regio area and shows details of the volcanic regions and colored deposits that characterize Io. North is at the top of the picture and the Sun illuminates the surface from the east (right). The smallest features that can be discerned here are approximately 23 kilometers (14 miles) in size, a resolution comparable to the best Voyager images of this face of Io. Io's surface is covered with volcanic deposits that are thought to contain ordinary silicate rock, along with various sulfur-rich compounds that give the satellite its distinctive color. In the brighter areas the surface is coated with frosts of sulfur dioxide. Dark areas are regions of current or recent volcanic activity. Planetary scientists say many changes are evident in the surface markings since this region of Io was imaged 17 years ago by the Voyager spacecraft. The bright regions near the eastern limb of the moon are much more prominent in the Galileo images than they were previously. Surface details have also changed dramatically in the vicinity of the eruptive volcano Masubi (the large, predominantly white feature seen near the 6 o'clock position in this view). Masubi was discovered as an active volcano during the Voyager encounters of Io in 1979.

Heat-induced Protein Structure and Subfractions in Relation to Protein Degradation Kinetics and Intestinal Availability in Dairy Cattle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doiron, K.; Yu, P; McKinnon, J

2009-01-01

The objectives of this study were to reveal protein structures of feed tissues affected by heat processing at a cellular level, using the synchrotron-based Fourier transform infrared microspectroscopy as a novel approach, and quantify protein structure in relation to protein digestive kinetics and nutritive value in the rumen and intestine in dairy cattle. The parameters assessed included (1) protein structure a-helix to e-sheet ratio; (2) protein subfractions profiles; (3) protein degradation kinetics and effective degradability; (4) predicted nutrient supply using the intestinally absorbed protein supply (DVE)/degraded protein balance (OEB) system for dairy cattle. In this study, Vimy flaxseed protein wasmore » used as a model feed protein and was autoclave-heated at 120C for 20, 40, and 60 min in treatments T1, T2, and T3, respectively. The results showed that using the synchrotron-based Fourier transform infrared microspectroscopy revealed and identified the heat-induced protein structure changes. Heating at 120C for 40 and 60 min increased the protein structure a-helix to e-sheet ratio. There were linear effects of heating time on the ratio. The heating also changed chemical profiles, which showed soluble CP decreased upon heating with concomitant increases in nonprotein nitrogen, neutral, and acid detergent insoluble nitrogen. The protein subfractions with the greatest changes were PB1, which showed a dramatic reduction, and PB2, which showed a dramatic increase, demonstrating a decrease in overall protein degradability. In situ results showed a reduction in rumen-degradable protein and in rumen-degradable dry matter without differences between the treatments. Intestinal digestibility, determined using a 3-step in vitro procedure, showed no changes to rumen undegradable protein. Modeling results showed that heating increased total intestinally absorbable protein (feed DVE value) and decreased degraded protein balance (feed OEB value), but there were no differences between the treatments. There was a linear effect of heating time on the DVE and a cubic effect on the OEB value. Our results showed that heating changed chemical profiles, protein structure a-helix to e-sheet ratio, and protein subfractions; decreased rumen-degradable protein and rumen-degradable dry matter; and increased potential nutrient supply to dairy cattle. The protein structure a-helix to e-sheet ratio had a significant positive correlation with total intestinally absorbed protein supply and negative correlation with degraded protein balance.« less

Negotiating for Change: Modifying Collective Bargaining Agreements for School Turnaround

ERIC Educational Resources Information Center

Weinberg, Rebecca

2011-01-01

Dramatically improving student achievement in a school that has been failing for many years requires dramatically different conditions. Only the most effective teachers and leaders should be in the building, and the leadership must have the flexibility to respond strategically to the needs of the students, with regular input from teachers.…

Dramatic Declines in Higher Education Appropriations: State Conditions for Budget Punctuations

ERIC Educational Resources Information Center

Li, Amy Y.

2017-01-01

Public colleges and universities depend heavily on state appropriations and legislatures must decide how much to fund higher education. This study applies punctuated equilibrium theory to characterize the distribution of annual changes in higher education appropriations and defines the threshold for a dramatic budget cut. Using data for the 50…

Archived DNA reveals fisheries and climate induced collapse of a major fishery.

PubMed

Bonanomi, Sara; Pellissier, Loïc; Therkildsen, Nina Overgaard; Hedeholm, Rasmus Berg; Retzel, Anja; Meldrup, Dorte; Olsen, Steffen Malskær; Nielsen, Anders; Pampoulie, Christophe; Hemmer-Hansen, Jakob; Wisz, Mary Susanne; Grønkjær, Peter; Nielsen, Einar Eg

2015-10-22

Fishing and climate change impact the demography of marine fishes, but it is generally ignored that many species are made up of genetically distinct locally adapted populations that may show idiosyncratic responses to environmental and anthropogenic pressures. Here, we track 80 years of Atlantic cod (Gadus morhua) population dynamics in West Greenland using DNA from archived otoliths in combination with fish population and niche based modeling. We document how the interacting effects of climate change and high fishing pressure lead to dramatic spatiotemporal changes in the proportions and abundance of different genetic populations, and eventually drove the cod fishery to a collapse in the early 1970s. Our results highlight the relevance of fisheries management at the level of genetic populations under future scenarios of climate change.

Archived DNA reveals fisheries and climate induced collapse of a major fishery

PubMed Central

Bonanomi, Sara; Pellissier, Loïc; Therkildsen, Nina Overgaard; Hedeholm, Rasmus Berg; Retzel, Anja; Meldrup, Dorte; Olsen, Steffen Malskær; Nielsen, Anders; Pampoulie, Christophe; Hemmer-Hansen, Jakob; Wisz, Mary Susanne; Grønkjær, Peter; Nielsen, Einar Eg

2015-01-01

Fishing and climate change impact the demography of marine fishes, but it is generally ignored that many species are made up of genetically distinct locally adapted populations that may show idiosyncratic responses to environmental and anthropogenic pressures. Here, we track 80 years of Atlantic cod (Gadus morhua) population dynamics in West Greenland using DNA from archived otoliths in combination with fish population and niche based modeling. We document how the interacting effects of climate change and high fishing pressure lead to dramatic spatiotemporal changes in the proportions and abundance of different genetic populations, and eventually drove the cod fishery to a collapse in the early 1970s. Our results highlight the relevance of fisheries management at the level of genetic populations under future scenarios of climate change. PMID:26489934

Archived DNA reveals fisheries and climate induced collapse of a major fishery

NASA Astrophysics Data System (ADS)

Bonanomi, Sara; Pellissier, Loïc; Therkildsen, Nina Overgaard; Hedeholm, Rasmus Berg; Retzel, Anja; Meldrup, Dorte; Olsen, Steffen Malskær; Nielsen, Anders; Pampoulie, Christophe; Hemmer-Hansen, Jakob; Wisz, Mary Susanne; Grønkjær, Peter; Nielsen, Einar Eg

2015-10-01

Fishing and climate change impact the demography of marine fishes, but it is generally ignored that many species are made up of genetically distinct locally adapted populations that may show idiosyncratic responses to environmental and anthropogenic pressures. Here, we track 80 years of Atlantic cod (Gadus morhua) population dynamics in West Greenland using DNA from archived otoliths in combination with fish population and niche based modeling. We document how the interacting effects of climate change and high fishing pressure lead to dramatic spatiotemporal changes in the proportions and abundance of different genetic populations, and eventually drove the cod fishery to a collapse in the early 1970s. Our results highlight the relevance of fisheries management at the level of genetic populations under future scenarios of climate change.

Impacts of land use and climate change on carbon dynamics in south-central Senegal

USGS Publications Warehouse

Liu, Shu-Guang; Kaire, M.; Wood, Eric C.; Diallo, O.; Tieszen, Larry L.

2004-01-01

Total carbon stock in vegetation and soils was reduced 37% in south-central Senegal from 1900 to 2000. The decreasing trend will continue during the 21st century unless forest clearing is stopped, selective logging dramatically reduced, and climate change, if any, relatively small. Developing a sustainable fuelwood and charcoal production system could be the most feasible and significant carbon sequestration project in the region. If future climate changes dramatically as some models have predicted, cropland productivity will drop more than 65% around 2100, posing a serious threat to food security and the efficiency of carbon sequestration projects.

Acid gelation properties of heated skim milk as a result of enzymatically induced changes in the micelle/serum distribution of the whey protein/kappa-casein aggregates.

PubMed

Guyomarc'h, Fanny; Renan, Marie; Chatriot, Marc; Gamerre, Valérie; Famelart, Marie-Hélène

2007-12-26

Changes in the acid gelation properties of skim milk as a result of variations in the micelle/serum distribution of the heat-induced whey protein/kappa-casein aggregates, induced by the combination of heat treatment and limited renneting, were investigated. No dramatic change in the zeta potential or the isoelectric point of the casein micelles was suggested, whether the aggregates were all attached to the casein micelle or not. Fluorescence intensity measurement using 8-anilino-1-naphthalenesulfonic acid (ANS) showed that the heat-induced aggregates were highly hydrophobic. Dynamic oscillation viscosimetry showed that acid gelation using glucono-delta-lactone (GDL) started at a higher pH value in prerenneted milk. However, no change in the gelation profile of skim milk could be related to the proportion of aggregates bound to the surface of the casein micelles. The results support the idea of an early interaction between the serum aggregates and the casein micelles on acidification.

Far-infrared spectral studies of phase changes in water ice induced by proton irradiation

NASA Technical Reports Server (NTRS)

Moore, Marla H.; Hudson, Reggie L.

1992-01-01

Changes in the FIR spectrum of crystalline and amorphous water ice as a function of temperature are reported. The dramatic differences between the spectra of these ices in the FIR are used to examine the effect of proton irradiation on the stability of the crystalline and amorphous ice phases from 13 to 77 K. In particular, the spectra near 13 K show interconversion between the amorphous and crystalline ice phases beginning at doses near 2 eV/molecule and continuing cyclically with increased dose. The results are used to estimate the stability of irradiated ices in astronomical environments.

Dermatology practice management enhancement: implications for dermatology in the age of managed care.

PubMed

Nestor, M S

2000-09-01

Health care delivery in the United States has changed dramatically during the past 10 years. Dermatologists are faced with challenging changes in the way they learn new skills, practice, and provide dermatologic care. Dermatologists can survive and flourish in this environment if they learn proper management and enhancement skills. These skills include proper coding and documentation, regulatory compliance, and new levels of practice effectiveness and efficiency. Dermatologists can offer also the benefit of cosmetic procedures and ethical office-based dispensing to their patients. Greater future unification of this specialty will allow dermatology to flourish and show its need, efficiency, and cost-effectiveness.

Evolutionary medicine: bottle feeding, birth spacing, and autism.

PubMed

Gallup, Gordon G; Hobbs, Dawn R

2011-09-01

To compensate for the high metabolic costs of lactation, the likelihood of re-impregnation shortly after childbirth is normally reduced due to hormonal changes triggered by breast feeding during the postpartum period. Nowadays, however, bottle feeding as a substitute for breast feeding precludes such changes and leads to early postpartum reinstatement of fertility. We suggest that recent data showing the risk of autism goes up dramatically as the time between pregnancies goes down [1] may be a byproduct of bottle feeding. The decision to bottle feed your last child may unwittingly put your next child at risk of being autistic. Copyright © 2011 Elsevier Ltd. All rights reserved.

Defending the solo and small practice neurologist.

PubMed

Jones, Elaine C; Evans, David A

2015-04-01

Changes in health care are having a dramatic effect on the practice of medicine. In 2005, a National Center for Health Statistics survey showed that 55%-70% of physicians are in small/solo practices. These data also demonstrated that 70% of physicians identified themselves as owners. Since passage of the Affordable Care Act (ACA) in 2010, neurologists report an 8% increase in academic practice settings, a 2% decrease in private practice settings, and a 5% decrease in solo practice settings. Surveys of family physicians showed that 60% are now employees of hospitals or larger groups. A survey by The Physicians Foundation showed that 89% of physicians believed that the traditional model of independent private practice is either "on shaky ground" or "a dinosaur soon to go extinct." With the changes expected from the ACA, solo/small practices will continue to face challenges and therefore must pay close attention to business and clinical metrics.

Investigation of Techniques for Inventorying Forested Regions. Volume 1: Reflectance Modeling and Empirical Multispectral Analysis of Forest Canopy Components

NASA Technical Reports Server (NTRS)

Nalepka, R. F. (Principal Investigator); Sadowski, F. G.; Malila, W. A.

1977-01-01

The author has identified the following significant results. Effects of vegetation density on overall canopy reflectance differed dramatically, depending on spectral band, base material, and vegetation type. For example, reflectance changes caused by variations in vegetation density were hardly apparant for a simulated burned surface in LANDSAT band 5, while large changes occurred in band 7. When increasing densities of tree overstory were placed over understories, intermediate to dense overstories effectively masked the understories and dominated the spectral signatures. Dramatic changes in reflectance occurred for canopies placed on a number of varying topographic positions. Such changes were seen to result in the spectral overlap of some nonforested with densely forested situations.

Burning Fossil Fuels: Impact of Climate Change on Health.

PubMed

Sommer, Alfred

2016-01-01

A recent, sophisticated granular analysis of climate change in the United States related to burning fossil fuels indicates a high likelihood of dramatic increases in temperature, wet-bulb temperature, and precipitation, which will dramatically impact the health and well-being of many Americans, particularly the young, the elderly, and the poor and marginalized. Other areas of the world, where they lack the resources to remediate these weather impacts, will be even more greatly affected. Too little attention is being paid to the impending health impact of accumulating greenhouse gases. © The Author(s) 2015.

The co-development of looking dynamics and discrimination performance

PubMed Central

Perone, Sammy; Spencer, John P.

2015-01-01

The study of looking dynamics and discrimination form the backbone of developmental science and are central processes in theories of infant cognition. Looking dynamics and discrimination change dramatically across the first year of life. Surprisingly, developmental changes in looking and discrimination have not been studied together. Recent simulations of a dynamic neural field (DNF) model of infant looking and memory suggest that looking and discrimination do change together over development and arise from a single neurodevelopmental mechanism. We probe this claim by measuring looking dynamics and discrimination along continuous, metrically organized dimensions in 5-, 7, and 10-month-old infants (N = 119). The results showed that looking dynamics and discrimination changed together over development and are linked within individuals. Quantitative simulations of a DNF model provide insights into the processes that underlie developmental change in looking dynamics and discrimination. Simulation results support the view that these changes might arise from a single neurodevelopmental mechanism. PMID:23957821

Spatial and temporal variation in climate change: A bird’s eye view

USGS Publications Warehouse

Fontaine, Joseph J.; Decker, Karie L.; Skagen, Susan K.; van Riper, Charles

2009-01-01

Recent changes in global climate have dramatically altered worldwide temperatures and the corresponding timing of seasonal climate conditions. Recognizing the degree to which species respond to changing climates is therefore an area of increasing conservation concern as species that are unable to respond face increased risk of extinction. Here we examine spatial and temporal heterogeneity in the rate of climate change across western North America and discuss the potential for conditions to arise that may limit the ability of western migratory birds to adapt to changing climates. Based on 52 years of climate data, we show that changes in temperature and precipitation differ significantly between spring migration habitats in the desert southwest and breeding habitats throughout western North America. Such differences may ultimately increase costs to individual birds and thereby threaten the long-term population viability of many species.

Sensory system plasticity in a visually specialized, nocturnal spider.

PubMed

Stafstrom, Jay A; Michalik, Peter; Hebets, Eileen A

2017-04-21

The interplay between an animal's environmental niche and its behavior can influence the evolutionary form and function of its sensory systems. While intraspecific variation in sensory systems has been documented across distant taxa, fewer studies have investigated how changes in behavior might relate to plasticity in sensory systems across developmental time. To investigate the relationships among behavior, peripheral sensory structures, and central processing regions in the brain, we take advantage of a dramatic within-species shift of behavior in a nocturnal, net-casting spider (Deinopis spinosa), where males cease visually-mediated foraging upon maturation. We compared eye diameters and brain region volumes across sex and life stage, the latter through micro-computed X-ray tomography. We show that mature males possess altered peripheral visual morphology when compared to their juvenile counterparts, as well as juvenile and mature females. Matching peripheral sensory structure modifications, we uncovered differences in relative investment in both lower-order and higher-order processing regions in the brain responsible for visual processing. Our study provides evidence for sensory system plasticity when individuals dramatically change behavior across life stages, uncovering new avenues of inquiry focusing on altered reliance of specific sensory information when entering a new behavioral niche.

Trophic specialization drives morphological evolution in sea snakes.

PubMed

Sherratt, Emma; Rasmussen, Arne R; Sanders, Kate L

2018-03-01

Viviparous sea snakes are the most rapidly speciating reptiles known, yet the ecological factors underlying this radiation are poorly understood. Here, we reconstructed dated trees for 75% of sea snake species and quantified body shape (forebody relative to hindbody girth), maximum body length and trophic diversity to examine how dietary specialization has influenced morphological diversification in this rapid radiation. We show that sea snake body shape and size are strongly correlated with the proportion of burrowing prey in the diet. Specialist predators of burrowing eels have convergently evolved a 'microcephalic' morphotype with dramatically reduced forebody relative to hindbody girth and intermediate body length. By comparison, snakes that predominantly feed on burrowing gobies are generally short-bodied and small-headed, but there is no evidence of convergent evolution. The eel specialists also exhibit faster rates of size and shape evolution compared to all other sea snakes, including those that feed on gobies. Our results suggest that trophic specialization to particular burrowing prey (eels) has invoked strong selective pressures that manifest as predictable and rapid morphological changes. Further studies are needed to examine the genetic and developmental mechanisms underlying these dramatic morphological changes and assess their role in sea snake speciation.

The transition of dynamic rupture styles in elastic media under velocity-weakening friction

NASA Astrophysics Data System (ADS)

Gabriel, A.-A.; Ampuero, J.-P.; Dalguer, L. A.; Mai, P. M.

2012-09-01

Although kinematic earthquake source inversions show dominantly pulse-like subshear rupture behavior, seismological observations, laboratory experiments and theoretical models indicate that earthquakes can operate with different rupture styles: either as pulses or cracks, that propagate at subshear or supershear speeds. The determination of rupture style and speed has important implications for ground motions and may inform about the state of stress and strength of active fault zones. We conduct 2D in-plane dynamic rupture simulations with a spectral element method to investigate the diversity of rupture styles on faults governed by velocity-and-state-dependent friction with dramatic velocity-weakening at high slip rate. Our rupture models are governed by uniform initial stresses, and are artificially initiated. We identify the conditions that lead to different rupture styles by investigating the transitions between decaying, steady state and growing pulses, cracks, sub-shear and super-shear ruptures as a function of background stress, nucleation size and characteristic velocity at the onset of severe weakening. Our models show that small changes of background stress or nucleation size may lead to dramatic changes of rupture style. We characterize the asymptotic properties of steady state and self-similar pulses as a function of background stress. We show that an earthquake may not be restricted to a single rupture style, but that complex rupture patterns may emerge that consist of multiple rupture fronts, possibly involving different styles and back-propagating fronts. We also demonstrate the possibility of a super-shear transition for pulse-like ruptures. Finally, we draw connections between our findings and recent seismological observations.

Drug Resistance to EGFR Inhibitors in Lung Cancer | Office of Cancer Genomics

Cancer.gov

The discovery of mutations in epidermal growth factor receptor (EGFR) has dramatically changed the treatment of patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths worldwide. EGFR-targeted therapies show considerable promise, but drug resistance has become a substantial issue. We reviewed the literature to provide an overview of the drug resistance to EGFR tyrosine kinase inhibitors (TKIs) in NSCLC. The mechanisms causing primary, acquired and persistent drug resistance to TKIs vary.

Non-classical Correlations and Quantum Coherence in Mixed Environments

NASA Astrophysics Data System (ADS)

Hu, Zheng-Da; Wei, Mei-Song; Wang, Jicheng; Zhang, Yixin; He, Qi-Liang

2018-05-01

We investigate non-classical correlations (entanglement and quantum discord) and quantum coherence for an open two-qubit system each independently coupled to a bosonic environment and a spin environment, respectively. The modulating effects of spin environment and bosonic environment are respectively explored. A relation among the quantum coherence, quantum discord and classical correlation is found during the sudden transition phenomenon. We also compare the case of mixed environments with that of the same environments, showing that the dynamics is dramatically changed.

Emissivity Measurements of Additively Manufactured Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morgan, Robert Vaughn; Reid, Robert Stowers; Baker, Andrew M.

The emissivity of common 3D printing materials such as ABS and PLA were measured using a reflectivity meter and have the measured value of approximately 0.92. Adding a conductive material to the filament appears to cause a decrease in the emissivity of the surface. The angular dependence of the emissivity and the apparent temperature was measured using a FLIR infrared camera showing that the emissivity does not change much for shallow angles less than 40 angular degrees, and drops off dramatically after 70 angular degrees.

How to Know when Dramatic Change Is on Track: Leading Indicators of School Turnarounds

ERIC Educational Resources Information Center

Kowal, Julie; Ableidinger, Joe

2011-01-01

In recent years, national policymakers have placed new emphasis on "school turnarounds" as a strategy for rapid, dramatic improvement in chronically failing schools, calling on education leaders to turn around performance in the 5,000 lowest-achieving schools nationwide. This goal may seem daunting, given the dismal success rates of…

Selection for Social Signalling Drives the Evolution of Chameleon Colour Change

PubMed Central

Stuart-Fox, Devi; Moussalli, Adnan

2008-01-01

Rapid colour change is a remarkable natural phenomenon that has evolved in several vertebrate and invertebrate lineages. The two principal explanations for the evolution of this adaptive strategy are (1) natural selection for crypsis (camouflage) against a range of different backgrounds and (2) selection for conspicuous social signals that maximise detectability to conspecifics, yet minimise exposure to predators because they are only briefly displayed. Here we show that evolutionary shifts in capacity for colour change in southern African dwarf chameleons (Bradypodion spp.) are associated with increasingly conspicuous signals used in male contests and courtship. To the chameleon visual system, species showing the most dramatic colour change display social signals that contrast most against the environmental background and amongst adjacent body regions. We found no evidence for the crypsis hypothesis, a finding reinforced by visual models of how both chameleons and their avian predators perceive chameleon colour variation. Instead, our results suggest that selection for conspicuous social signals drives the evolution of colour change in this system, supporting the view that transitory display traits should be under strong selection for signal detectability. PMID:18232740

Phytoplankton community structure is influenced by seabird guano enrichment in the Southern Ocean

NASA Astrophysics Data System (ADS)

Shatova, O. A.; Wing, S. R.; Hoffmann, L. J.; Wing, L. C.; Gault-Ringold, M.

2017-05-01

Phytoplankton biomass, productivity and community structure are strongly influenced by differences in nutrient concentrations among oceanographic water masses. Changes in community composition, particularly in the distribution of cell sizes, can result in dramatic changes in the energetics of pelagic food webs and ecosystem function in terms of biogeochemical cycling and carbon sequestration. Here we examine responses of natural phytoplankton communities from four major water masses in the Southern Ocean to enrichment from seabird guano, a concentrated source of bioactive metals (Mn, Fe, Co, Ni, Cu, Zn) and macronutrients (N, P), in a series of incubation experiments. Phytoplankton communities from sub-tropical water, modified sub-tropical water from the Snares Island wake, sub-Antarctic water and Antarctic water from the Ross Sea, each showed dramatic changes in community structure following additions of seabird guano. We observed particularly high growth of prymnesiophytes in response to the guano-derived nutrients within sub-Antarctic and sub-tropical frontal zones, resulting in communities dominated by larger cell sizes than in control incubations. Community changes within treatments enriched with guano were distinct, and in most cases more extensive, than those observed for treatments with additions of macronutrients (N, P) or iron (Fe) alone. These results provide the first empirical evidence that seabird guano enrichment can drive significant changes in the structure and composition of natural phytoplankton communities. Our findings have important implications for understanding the consequences of accumulation of bioactive metals and macronutrients within food webs and the role of seabirds as nutrient vectors within the Southern Ocean ecosystem.

Analyzing Land Use Changes in the Metropolitan Jilin City of Northeastern China Using Remote Sensing and GIS.

PubMed

Hu, Dan; Yang, Guodong; Wu, Qiong; Li, Hongqing; Liu, Xusheng; Niu, Xuefeng; Wang, Zhiheng; Wang, Qiong

2008-09-03

Remote sensing and GIS have been widely employed to study temporal and spatial urban land use changes in southern and southeastern China. However, few studies have been conducted in northeastern regions. This study analyzed land use change and spatial patterns of urban expansion in the metropolitan area of Jilin City, located on the extension of Changbai Mountain, based on aerial photos from 1989 and 2005 Spot images. The results indicated that urban land and transportation land increased dramatically (by 94.04% and 211.20%, respectively); isolated industrial and mining land decreased moderately (by 29.54%); rural residential land increased moderately (by 26.48%); dry land and paddy fields increased slightly (by 15.68% and 11.78%, respectively); forest and orchards decreased slightly (by 5.27% and 4.61%, respectively); grasslands and unused land decreased dramatically (by 99.12% and 86.04%, respectively). Sloped dry land (more than 4 degrees) was mainly distributed on the land below 10 degrees with an east, southeastern and south sunny direction aspect, and most sloped dry land transformed to forest was located on an east aspect lower than 12 degrees, while forest changed to dry land were mainly distributed on east and south aspects lower than 10 degrees. A spatial dependency analysis of land use change showed that the increased urban land was a logarithmic function of distance to the Songhua River. This study also provided some data with spatial details about the uneven land development in the upstream areas of Songhua River basin.

Land-cover change detection

USGS Publications Warehouse

Chen, Xuexia; Giri, Chandra; Vogelmann, James

2012-01-01

Land cover is the biophysical material on the surface of the earth. Land-cover types include grass, shrubs, trees, barren, water, and man-made features. Land cover changes continuously.  The rate of change can be either dramatic and abrupt, such as the changes caused by logging, hurricanes and fire, or subtle and gradual, such as regeneration of forests and damage caused by insects (Verbesselt et al., 2001).  Previous studies have shown that land cover has changed dramatically during the past sevearal centuries and that these changes have severely affected our ecosystems (Foody, 2010; Lambin et al., 2001). Lambin and Strahlers (1994b) summarized five types of cause for land-cover changes: (1) long-term natural changes in climate conditions, (2) geomorphological and ecological processes, (3) human-induced alterations of vegetation cover and landscapes, (4) interannual climate variability, and (5) human-induced greenhouse effect.  Tools and techniques are needed to detect, describe, and predict these changes to facilitate sustainable management of natural resources.

Hasty retreat of glaciers in the Palena province of Chile

NASA Astrophysics Data System (ADS)

Paul, F.; Mölg, N.; Bolch, T.

2013-12-01

Mapping glacier extent from optical satellite data has become a most efficient tool to create or update glacier inventories and determine glacier changes over time. A most valuable archive in this regard is the nearly 30-year time series of Landsat Thematic Mapper (TM) data that is freely available (already orthorectified) for most regions in the world from the USGS. One region with a most dramatic glacier shrinkage and a missing systematic assessment of changes, is the Palena province in Chile, south of Puerto Montt. A major bottleneck for accurate determination of glacier changes in this region is related to the huge amounts of snow falling in this very maritime region, hiding the perimeter of glaciers throughout the year. Consequently, we found only three years with Landsat scenes that can be used to map glacier extent through time. We here present the results of a glacier change analysis from six Landsat scenes (path-rows 232-89/90) acquired in 1985, 2000 and 2011 covering the Palena district in Chile. Clean glacier ice was mapped automatically with a standard technique (TM3/TM band ratio) and manual editing was applied to remove wrongly classified lakes and to add debris-covered glacier parts. The digital elevation model (DEM) from SRTM was used to derive drainage divides, determine glacier specific topographic parameters, and analyse the area changes in regard to topography. The scene from 2000 has the best snow conditions and was used to eliminate seasonal snow in the other two scenes by digital combination of the binary glacier masks. The observed changes show a huge spatial variability with a strong dependence on elevation and glacier hypsometry. While small mountain glaciers at high elevations and steep slopes show virtually no change over the 26-year period, ice at low elevations from large valley glaciers shows a dramatic decline (area and thickness loss). Some glaciers retreated more than 3 km over this time period or even disappeared completely. Typically, these glaciers lost contact to the accumulation areas of tributaries and now consist of an ablation area only. Furthermore, numerous pro-glacial lakes formed or expanded rapidly, increasing the local hazard potential. On the other hand, some glaciers located on or near to (still active) volcanoes have also advanced in the same time period. Observed trends in temperature (decreasing) are in contrast to the observed strong glacier shrinkage.

Nonlinear Scattering of VLF Waves in the Radiation Belts

NASA Astrophysics Data System (ADS)

Crabtree, Chris; Rudakov, Leonid; Ganguli, Guru; Mithaiwala, Manish

2014-10-01

Electromagnetic VLF waves, such as whistler mode waves, control the lifetime of trapped electrons in the radiation belts by pitch-angle scattering. Since the pitch-angle scattering rate is a strong function of the wave properties, a solid understanding of VLF wave sources and propagation in the magnetosphere is critical to accurately calculate electron lifetimes. Nonlinear scattering (Nonlinear Landau Damping) is a mechanism that can strongly alter VLF wave propagation [Ganguli et al. 2010], primarily by altering the direction of propagation, and has not been accounted for in previous models of radiation belt dynamics. Laboratory results have confirmed the dramatic change in propagation direction when the pump wave has sufficient amplitude to exceed the nonlinear threshold [Tejero et al. 2014]. Recent results show that the threshold for nonlinear scattering can often be met by naturally occurring VLF waves in the magnetosphere, with wave magnetic fields of the order of 50-100 pT inside the plasmapause. Nonlinear scattering can then dramatically alter the macroscopic dynamics of waves in the radiation belts leading to the formation of a long-lasting wave-cavity [Crabtree et al. 2012] and, when amplification is present, a multi-pass amplifier [Ganguli et al. 2012]. By considering these effects, the lifetimes of electrons can be dramatically reduced. This work is supported by the Naval Research Laboratory base program.

Disease ecology and the global emergence of zoonotic pathogens.

PubMed

Wilcox, Bruce A; Gubler, Duane J

2005-09-01

The incidence and frequency of epidemic transmission of zoonotic diseases, both known and newly recognized, has increased dramatically in the past 30 years. It is thought that this dramatic disease emergence is primarily the result of the social, demographic, and environmental transformation that has occurred globally since World War II. However, the causal linkages have not been elucidated. Investigating emerging zoonotic pathogens as an ecological phenomenon can provide significant insights as to why some of these pathogens have jumped species and caused major epidemics in humans. A review of concepts and theory from biological ecology and of causal factors in disease emergence previously described suggests a general model of global zoonotic disease emergence. The model links demographic and societal factors to land use and land cover change whose associated ecological factors help explain disease emergence. The scale and magnitude of these changes are more significant than those associated with climate change, the effects of which are largely not yet understood. Unfortunately, the complex character and non-linear behavior of the human-natural systems in which host-pathogen systems are embedded makes specific incidences of disease emergence or epidemics inherently difficult to predict. Employing a complex systems analytical approach, however, may show how a few key ecological variables and system properties, including the adaptive capacity of institutions, explains the emergence of infectious diseases and how an integrated, multi-level approach to zoonotic disease control can reduce risk.

Cp Asymmetries in B0DECAYS Beyond the Standard Model

NASA Astrophysics Data System (ADS)

Dib, Claudio O.; London, David; Nir, Yosef

Of the many ingredients of the Standard Model that are relevant to the analysis of CP asymmetries in B0 decays, some are likely to hold even beyond the Standard Model while others are sensitive to new physics. Consequently, certain predictions are maintained while others may show dramatic deviations from the Standard Model. Many classes of models may show clear signatures when the asymmetries are measured: four quark generations, Z-mediated flavor-changing neutral currents, supersymmetry and “real superweak” models. On the other hand, models of left-right symmetry and multi-Higgs sectors with natural flavor conservation are unlikely to modify the Standard Model predictions.

Luminescent Li-based metal-organic framework tailored for the selective detection of explosive nitroaromatic compounds: direct observation of interaction sites.

PubMed

Kim, Tae Kyung; Lee, Jae Hwa; Moon, Dohyun; Moon, Hoi Ri

2013-01-18

A luminescent lithium metal-organic framework (MOF) is constructed from the solvothermal reaction of Li(+) and a well-designed organic ligand, bis(4-carboxyphenyl)-N-methylamine (H(2)CPMA). A Li-based MOF can detect an explosive aromatic compound containing nitro groups as an explosophore, by showing a dramatic color change with concurrent luminescence quenching in the solid state. The detection sites are proven directly through single-crystal-to-single-crystal transformations, which show strong interactions between the aromatic rings of the electron-rich CPMA(2-) molecules and the electron-deficient nitrobenzene.

Relating structure with morphology: A comparative study of perfect Langmuir Blodgett multilayers

NASA Astrophysics Data System (ADS)

Mukherjee, Smita; Datta, Alokmay; Giglia, Angelo; Mahne, Nichole; Nannarone, Stefano

2008-01-01

Atomic force microscopy and X-ray reflectivity of metal-stearate (MSt) Langmuir-Blodgett films on hydrophilic Silicon (1 0 0), show dramatic reduction in 'pinhole' defects when metal M is changed from Cd to Co, along with excellent periodicity in multilayer, with hydrocarbon tails tilted 9.6° from vertical for CoSt (untilted for CdSt). Near edge X-ray absorption fine structure (NEXAFS) and Fourier transform infra-red (FTIR) spectroscopies indicate bidentate bridging metal-carboxylate coordination in CoSt (unidentate in CdSt), underscoring role of headgroup structure in determining morphology. FTIR studies also show increased packing density in CoSt, consistent with increased coverage.

Dongting Lake, China

NASA Image and Video Library

2002-09-15

These images show dramatic change in the water at Dongting Lake in Hunan province, China. A flood crest surged down the Yangtze River in late August of this year, but the embankments made by residents there held. The left image was acquired on September 2, 2002 and shows the extent of the lake. The right image was obtained March 19, 2002 before the flooding began. These images were acquired on September 2, 2002 and March 19, 2002 by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER will image Earth for the next 6 years to map and monitor the changing surface of our planet. http://photojournal.jpl.nasa.gov/catalog/PIA03858

Conserving biodiversity on Mongolian Rangelands: Implications for protected area development and pastoral uses

Treesearch

Richard P. Reading; Donald J. Bedunah; Sukhiin Amgalanbaatar

2006-01-01

Mongolia is a sparsely populated country with over 80 percent of its land used by pastoralists for extensive livestock grazing. Mongolia’s wildlife and pastoralists have faced dramatic challenges with the recent rapid socioeconomic changes. Livestock numbers increased dramatically in the 1990s following the transition from communism to democracy and capitalism. Yet,...

Japan's Democracy: How Much Change? Headline Series No. 305.

ERIC Educational Resources Information Center

Krauss, Ellis S.

This booklet analyzes the changes that have occurred in Japan in the postwar period. The book is divided into four chapters. Chapter 1, "Revolutionary Change: American Occupation, 1945-52," focuses on the dramatic changes brought by Occupation forces. Chapter 2, "Evolutionary Change: Japan's Democracy from the Occupation through the…

Some guidelines for helping natural resources adapt to climate change

Treesearch

Jill S. Baron; Susan Herrod Julius; Jordan M. West; Linda A. Joyce; Geoffrey Blate; Charles H. Peterson; Margaret Palmer; Brian D. Keller; Peter Kareiva; J. Michael Scott; Brad Griffith

2008-01-01

The changes occurring in mountain regions are an epitome of climate change. The dramatic shrinkage of major glaciers over the past century - and especially in the last 30 years - is one of several iconic images that have come to symbolize climate change.

Climate change damages to Alaska public infrastructure and the economics of proactive adaptation

EPA Science Inventory

Climate change in the circumpolar region is causing dramatic environmental change that increases the vulnerability of the built environment. We quantified the economic impacts of climate change on Alaska’s public infrastructure under relatively high and low climate forcing scenar...

An investigation into the effects of antenatal stressors on the postpartum neuroimmune profile and depressive-like behaviors

PubMed Central

Posillico, Caitlin K.; Schwarz, Jaclyn M.

2015-01-01

Postpartum depression is a specific type of depression that affects approximately 10-15% of mothers (Wisner et al., 2013). While many have attributed the etiology of postpartum depression to the dramatic change in hormone levels that occurs immediately postpartum, the exact causes are not well-understood. It is well-known; however, that pregnancy induces a number of dramatic changes in the peripheral immune system that foster the development of the growing fetus. It is also well-known that changes in immune function, specifically within the brain, have been linked to several neuropsychiatric disorders including depression. Thus, we sought to determine whether pregnancy induces significant neuroimmune changes postpartum and whether stress or immune activation during pregnancy induce a unique neuroimmune profile that may be associated with depressive-like behaviors postpartum. We used late-gestation sub-chronic stress and late-gestation acute immune activation to examine the postpartum expression of depressive-like behaviors, microglial activation markers, and inflammatory cytokines within the medial prefrontal cortex (mPFC) and the hippocampus (HP). The expression of many immune molecules was significantly altered in the brain postpartum, and postpartum females also showed significant anhedonia, both independently of stress. Following late-gestation immune activation, we found a unique set of changes in neuroimmune gene expression immediately postpartum. Thus, our data indicate that even in the absence of additional stressors, postpartum females exhibit significant changes in the expression of cytokines within the brain that are associated with depressive-like behavior. Additionally, different forms of antenatal stress produce varying profiles of postpartum neuroimmune gene expression and associated depressive-like behaviors. PMID:26589802

Consequences of a warming climate for social organisation in sweat bees.

PubMed

Schürch, Roger; Accleton, Christopher; Field, Jeremy

The progression from solitary living to caste-based sociality is commonly regarded as a major evolutionary transition. However, it has recently been shown that in some taxa, sociality may be plastic and dependent on local conditions. If sociality can be environmentally driven, the question arises as to how projected climate change will influence features of social organisation that were previously thought to be of macroevolutionary proportions. Depending on the time available in spring during which a foundress can produce worker offspring, the sweat bee Halictus rubicundus is either social or solitary. We analysed detailed foraging data in relation to climate change predictions for Great Britain to assess when and where switches from a solitary to social lifestyle may be expected. We demonstrate that worker numbers should increase throughout Great Britain under predicted climate change scenarios, and importantly, that sociality should appear in northern areas where it has never before been observed. This dramatic shift in social organisation due to climate change should lead to a bigger workforce being available for summer pollination and may contribute towards mitigating the current pollinator crisis. The sweat bee Halictus rubicundus is socially polymorphic, expressing both solitary and social forms, and is socially plastic, capable of transitioning from solitary to social forms, depending on local environmental conditions. Here, we analyse detailed foraging data in relation to climate change predictions for Great Britain to show that worker numbers and sociality both increase under predicted climate change scenarios. Especially dramatic will be the appearance of social H. rubicundus nests in the north of Britain, where previously only solitary forms are found. Particularly, if more taxa are found to be socially plastic, environmentally driven shifts in social organisation may help to mitigate future pollinator crises by providing more individuals for pollination.

Temporal trends in the use of drug-eluting stents for approved and off-label indications: a longitudinal analysis of a large multicenter percutaneous coronary intervention registry.

PubMed

Gualano, Sarah K; Gurm, Hitinder S; Share, David; Smith, Dean; Aronow, Herbert D; LaLonde, Thomas; Bates, Eric R; Changezi, Hameem; McNamara, Richard; Moscucci, Mauro

2010-02-01

We sought to examine the temporal variations in the rate of both bare-metal stent (BMS) and drug-eluting stent (DES) use for off-label indications after the reports of an increased risk of very late stent thrombosis in patients with DES at the 2006 meeting of the European Society of Cardiology (ESC). To determine whether the decrease in use of DES has affected both on and off-label indications. The study cohort included patients undergoing coronary intervention in a large regional registry, the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2). Patient demographic and clinical characteristics for patients with DES in the third quarter of 2006 (pre-ESC) were compared to those from the fourth quarter of 2008 (post-guideline changes). Use of DES for off-label indications, such as ST-segment elevation myocardial infarction (STEMI), in-stent restenosis (ISR), and saphenous vein graft (SVG) interventions, were evaluated. The overall deployment of DES fell sharply from 83% pre-ESC to a plateau of 58% in the first quarter of 2008. This corresponded to a rise in BMS use, while angioplasty procedures stayed the same. The STEMI subgroup showed the most dramatic change, from 78% to only 36%. Off-label use in SVGs showed a similar trend, from 74% to 43%. Drug-eluting stent deployment for ISR was less affected, though it also fell 25% (from 79%-56%). The use of DES has fallen dramatically from June 2006 to December 2008, particularly for nonapproved indications. Our study provides a real-world assessment of contemporary change in DES use in response to the presentation of negative observational studies. Copyright 2010 Wiley Periodicals, Inc.

Diet and the evolution of the earliest human ancestors

PubMed Central

Teaford, Mark F.; Ungar, Peter S.

2000-01-01

Over the past decade, discussions of the evolution of the earliest human ancestors have focused on the locomotion of the australopithecines. Recent discoveries in a broad range of disciplines have raised important questions about the influence of ecological factors in early human evolution. Here we trace the cranial and dental traits of the early australopithecines through time, to show that between 4.4 million and 2.3 million years ago, the dietary capabilities of the earliest hominids changed dramatically, leaving them well suited for life in a variety of habitats and able to cope with significant changes in resource availability associated with long-term and short-term climatic fluctuations. PMID:11095758

Ca2+-induced changes in the secondary structure of a 60 kDa phosphoinositide-specific phospholipase C from bovine brain cytosol.

PubMed Central

Herrero, C; Cornet, M E; Lopez, C; Barreno, P G; Municio, A M; Moscat, J

1988-01-01

The purification to homogeneity of a 60 kDa phosphoinositide-specific phospholipase C from bovine brain cytosol is reported here. This enzyme exhibits the same properties, in terms of response to Ca2+, as does the cytosolic activity in a variety of cell types. We show here that Ca2+ does not appear to modulate the binding of the enzyme to the substrate, but induces dramatic changes in its secondary structure. Therefore we suggest that a decrease in the alpha-helix content of this enzyme correlates with its ability to be activated by Ca2+. Images Fig. 1. PMID:2850798

Large thermoelectric efficiency of doped polythiophene junction: A density functional study

NASA Astrophysics Data System (ADS)

Golsanamlou, Zahra; Bagheri Tagani, Meysam; Rahimpour Soleimani, Hamid

2018-06-01

The thermoelectric properties of polythiophene (PT) coupled to the Au (111) electrodes are studied based on density functional theory with nonequilibrium Green function formalism. Specially, the effect of Li and Cl adsorbents on the thermoelectric efficiency of the PT junction is investigated in different concentrations of the dopants for two lengths of the PT. Results show that the presence of dopants can bring the structural changes in the oligomer and modify the arrangement of the molecular levels leading to the dramatic changes in the transmission spectra of the junction. Therefore, the large enhancement in thermopower and consequently figure of merit is obtained by dopants which makes the doped PT junction as a beneficial thermoelectric device.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willey, Trevor M.; Lauderbach, Lisa; Gagliardi, Franco

HMX-based explosives LX-10 and PBX-9501 were heated through the β-δ phase transition. Ultra-small angle x-ray scattering (USAXS) and molecular diffraction were simultaneously recorded as the HMX was heated. Mesoscale voids and structure dramatically change promptly with the β-δ phase transition, rather than with other thermal effects. Also, x-ray induced damage, observed in the USAXS, occurs more readily at elevated temperatures; as such, the dose was reduced to mitigate this effect. Optical microscopy performed during a similar heating cycle gives an indication of changes on longer length scales, while x-ray microtomography, performed before and after heating, shows the character of extensivemore » microstructural damage resulting from the temperature cycle and solid-state phase transition.« less

Evolution of Sex-Specific Traits through Changes in HOX-Dependent doublesex Expression

PubMed Central

Tanaka, Kohtaro; Barmina, Olga; Sanders, Laura E.; Arbeitman, Michelle N.; Kopp, Artyom

2011-01-01

Almost every animal lineage is characterized by unique sex-specific traits, implying that such traits are gained and lost frequently in evolution. However, the genetic mechanisms responsible for these changes are not understood. In Drosophila, the activity of the sex determination pathway is restricted to sexually dimorphic tissues, suggesting that spatial regulation of this pathway may contribute to the evolution of sex-specific traits. We examine the regulation and function of doublesex (dsx), the main transcriptional effector of the sex determination pathway, in the development and evolution of Drosophila sex combs. Sex combs are a recent evolutionary innovation and show dramatic diversity in the relatively few Drosophila species that have them. We show that dsx expression in the presumptive sex comb region is activated by the HOX gene Sex combs reduced (Scr), and that the male isoform of dsx up-regulates Scr so that both genes become expressed at high levels in this region in males but not in females. Precise spatial regulation of dsx is essential for defining sex comb position and morphology. Comparative analysis of Scr and dsx expression reveals a tight correlation between sex comb morphology and the expression patterns of both genes. In species that primitively lack sex combs, no dsx expression is observed in the homologous region, suggesting that the origin and diversification of this structure were linked to the gain of a new dsx expression domain. Two other, distantly related fly lineages that independently evolved novel male-specific structures show evolutionary gains of dsx expression in the corresponding tissues, where dsx may also be controlled by Scr. These findings suggest that changes in the spatial regulation of sex-determining genes are a key mechanism that enables the evolution of new sex-specific traits, contributing to some of the most dramatic examples of phenotypic diversification in nature. PMID:21886483

Dramatic decreases in runoff and sediment load in the Huangfuchuan Basin of the Middle Yellow River, China: historical records and future projections

NASA Astrophysics Data System (ADS)

LI, E.; Li, D.; Wang, Y.; Fu, X.

2017-12-01

The Yellow River is well known for its high sediment load and serious water shortage. The long-term averaged sediment load is about 1.6´103 million tons per year, resulting in aggrading and perched lower reaches. In recent years, however, dramatic decreases in runoff and sediment load have been observed. The annual sediment load has been less than 150 million tons in the last ten years. Extrapolation of this trend into the future would motivate substantial change in the management strategies of the Lower Yellow River. To understand the possible trend and its coevolving drivers, we performed a case study of the Huangfuchuang River, which is a tributary to the Middle Yellow River, with a drainage area of 3246 km2 and an annual precipitation of 365 mm. Statistical analysis of historical data from 1960s to 2015 showed a significantly decreasing trend in runoff and sediment load since 1984. As potential drivers, the precipitation does not show an obvious change in annual amount, while the vegetation cover and the number of check dams have been increased gradually as a result of the national Grain for Green project. A simulation with the Soil and Water Assessment Tool (SWAT) reproduced the historical evolution processes, and showed that human activities dominated the reduction in runoff and sediment load, with a contribution of around 80%. We then projected the runoff and sediment load for the next 50 years (2016-2066), considering typical scenarios of climate change and accounting for vegetation cover development subject to climate conditions and storage capacity loss of check dams due to sediment deposition. The differences between the projected trend and the historical record were analyzed, so as to highlight the coevolving processes of climate, vegetation, and check dam retention on a time scale of decades. Keywords: Huangfuchuan River Basin, sediment load, vegetation cover, check dams, annual precipitation, SWAT.

Mid-infrared Variability of Changing-look AGNs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheng, Zhenfeng; Wang, Tinggui; Jiang, Ning

2017-09-01

It is known that some active galactic nuclei (AGNs) transit from Type 1 to Type 2 or vice versa. There are two explanations for the so-called changing-look AGNs: one is the dramatic change of the obscuration along the line of sight, and the other is the variation of accretion rate. In this Letter, we report the detection of large amplitude variations in the mid-infrared luminosity during the transitions in 10 changing-look AGNs using the Wide-field Infrared Survey Explorer ( WISE ) and newly released Near-Earth Object WISE Reactivation data. The mid-infrared light curves of 10 objects echo the variability inmore » the optical band with a time lag expected for dust reprocessing. The large variability amplitude is inconsistent with the scenario of varying obscuration, rather it supports the scheme of dramatic change in the accretion rate.« less

Free energy change of a dislocation due to a Cottrell atmosphere

DOE PAGES

Sills, R. B.; Cai, W.

2018-03-07

The free energy reduction of a dislocation due to a Cottrell atmosphere of solutes is computed using a continuum model. In this work, we show that the free energy change is composed of near-core and far-field components. The far-field component can be computed analytically using the linearized theory of solid solutions. Near the core the linearized theory is inaccurate, and the near-core component must be computed numerically. The influence of interactions between solutes in neighbouring lattice sites is also examined using the continuum model. We show that this model is able to reproduce atomistic calculations of the nickel–hydrogen system, predictingmore » hydride formation on dislocations. The formation of these hydrides leads to dramatic reductions in the free energy. Lastly, the influence of the free energy change on a dislocation’s line tension is examined by computing the equilibrium shape of a dislocation shear loop and the activation stress for a Frank–Read source using discrete dislocation dynamics.« less

Impacts of climate change and establishing a vegetation cover on water erosion of contaminated spoils for two contrasting United Kingdom regional climates: a case study approach.

PubMed

De Munck, Cécile S; Hutchings, Tony R; Moffat, Andy J

2008-10-01

This study examines how pollutant linkage of contaminants will be influenced by predicted changes in precipitation and subsequent rainfall erosion of soils and spoils in the United Kingdom during the 21st century. Two contrasting regional climates were used in conjunction with 2 extreme emissions scenarios (low and high greenhouse gas emissions) to run the Revised Universal Soil Loss Equation 2 (RUSLE2) model for a case study that represents a high risk of pollutant linkage through water erosion. Results for the 2 scenarios and the 2 regions showed a significant and gradual increase in erosion rates with time as a consequence of climate change, by up to 32% for the southwest and 6.6% for the southeast regions by the 2080s. Revegetation of the site showed a dramatic reduction in predicted future amounts of sediment production and subsequent contaminant movement, well below existing levels. Limitations and future improvements of the methodology are discussed.

Free energy change of a dislocation due to a Cottrell atmosphere

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sills, R. B.; Cai, W.

The free energy reduction of a dislocation due to a Cottrell atmosphere of solutes is computed using a continuum model. In this work, we show that the free energy change is composed of near-core and far-field components. The far-field component can be computed analytically using the linearized theory of solid solutions. Near the core the linearized theory is inaccurate, and the near-core component must be computed numerically. The influence of interactions between solutes in neighbouring lattice sites is also examined using the continuum model. We show that this model is able to reproduce atomistic calculations of the nickel–hydrogen system, predictingmore » hydride formation on dislocations. The formation of these hydrides leads to dramatic reductions in the free energy. Lastly, the influence of the free energy change on a dislocation’s line tension is examined by computing the equilibrium shape of a dislocation shear loop and the activation stress for a Frank–Read source using discrete dislocation dynamics.« less

Glycine Insertion Makes Yellow Fluorescent Protein Sensitive to Hydrostatic Pressure

PubMed Central

Watanabe, Tomonobu M.; Imada, Katsumi; Yoshizawa, Keiko; Nishiyama, Masayoshi; Kato, Chiaki; Abe, Fumiyoshi; Morikawa, Takamitsu J.; Kinoshita, Miki; Fujita, Hideaki; Yanagida, Toshio

2013-01-01

Fluorescent protein-based indicators for intracellular environment conditions such as pH and ion concentrations are commonly used to study the status and dynamics of living cells. Despite being an important factor in many biological processes, the development of an indicator for the physicochemical state of water, such as pressure, viscosity and temperature, however, has been neglected. We here found a novel mutation that dramatically enhances the pressure dependency of the yellow fluorescent protein (YFP) by inserting several glycines into it. The crystal structure of the mutant showed that the tyrosine near the chromophore flipped toward the outside of the β-can structure, resulting in the entry of a few water molecules near the chromophore. In response to changes in hydrostatic pressure, a spectrum shift and an intensity change of the fluorescence were observed. By measuring the fluorescence of the YFP mutant, we succeeded in measuring the intracellular pressure change in living cell. This study shows a new strategy of design to engineer fluorescent protein indicators to sense hydrostatic pressure. PMID:24014139

Free energy change of a dislocation due to a Cottrell atmosphere

NASA Astrophysics Data System (ADS)

Sills, R. B.; Cai, W.

2018-06-01

The free energy reduction of a dislocation due to a Cottrell atmosphere of solutes is computed using a continuum model. We show that the free energy change is composed of near-core and far-field components. The far-field component can be computed analytically using the linearized theory of solid solutions. Near the core the linearized theory is inaccurate, and the near-core component must be computed numerically. The influence of interactions between solutes in neighbouring lattice sites is also examined using the continuum model. We show that this model is able to reproduce atomistic calculations of the nickel-hydrogen system, predicting hydride formation on dislocations. The formation of these hydrides leads to dramatic reductions in the free energy. Finally, the influence of the free energy change on a dislocation's line tension is examined by computing the equilibrium shape of a dislocation shear loop and the activation stress for a Frank-Read source using discrete dislocation dynamics.

Temporal dynamics of the Saccharopolyspora erythraea phosphoproteome.

PubMed

Licona-Cassani, Cuauhtemoc; Lim, Sooa; Marcellin, Esteban; Nielsen, Lars K

2014-05-01

Actinomycetes undergo a dramatic reorganization of metabolic and cellular machinery during a brief period of growth arrest ("metabolic switch") preceding mycelia differentiation and the onset of secondary metabolite biosynthesis. This study explores the role of phosphorylation in coordinating the metabolic switch in the industrial actinomycete Saccharopolyspora erythraea. A total of 109 phosphopeptides from 88 proteins were detected across a 150-h fermentation using open-profile two-dimensional LC-MS proteomics and TiO(2) enrichment. Quantitative analysis of the phosphopeptides and their unphosphorylated cognates was possible for 20 pairs that also displayed constant total protein expression. Enzymes from central carbon metabolism such as putative acetyl-coenzyme A carboxylase, isocitrate lyase, and 2-oxoglutarate dehydrogenase changed dramatically in the degree of phosphorylation during the stationary phase, suggesting metabolic rearrangement for the reutilization of substrates and the production of polyketide precursors. In addition, an enzyme involved in cellular response to environmental stress, trypsin-like serine protease (SACE_6340/NC_009142_6216), decreased in phosphorylation during the growth arrest stage. More important, enzymes related to the regulation of protein synthesis underwent rapid phosphorylation changes during this stage. Whereas the degree of phosphorylation of ribonuclease Rne/Rng (SACE_1406/NC_009142_1388) increased during the metabolic switch, that of two ribosomal proteins, S6 (SACE_7351/NC_009142_7233) and S32 (SACE_6101/NC_009142_5981), dramatically decreased during this stage of the fermentation, supporting the hypothesis that ribosome subpopulations differentially regulate translation before and after the metabolic switch. Overall, we show the great potential of phosphoproteomic studies to explain microbial physiology and specifically provide evidence of dynamic protein phosphorylation events across the developmental cycle of actinomycetes.

Temporal Dynamics of the Saccharopolyspora erythraea Phosphoproteome*

PubMed Central

Licona-Cassani, Cuauhtemoc; Lim, SooA; Marcellin, Esteban; Nielsen, Lars K.

2014-01-01

Actinomycetes undergo a dramatic reorganization of metabolic and cellular machinery during a brief period of growth arrest (“metabolic switch”) preceding mycelia differentiation and the onset of secondary metabolite biosynthesis. This study explores the role of phosphorylation in coordinating the metabolic switch in the industrial actinomycete Saccharopolyspora erythraea. A total of 109 phosphopeptides from 88 proteins were detected across a 150-h fermentation using open-profile two-dimensional LC-MS proteomics and TiO2 enrichment. Quantitative analysis of the phosphopeptides and their unphosphorylated cognates was possible for 20 pairs that also displayed constant total protein expression. Enzymes from central carbon metabolism such as putative acetyl-coenzyme A carboxylase, isocitrate lyase, and 2-oxoglutarate dehydrogenase changed dramatically in the degree of phosphorylation during the stationary phase, suggesting metabolic rearrangement for the reutilization of substrates and the production of polyketide precursors. In addition, an enzyme involved in cellular response to environmental stress, trypsin-like serine protease (SACE_6340/NC_009142_6216), decreased in phosphorylation during the growth arrest stage. More important, enzymes related to the regulation of protein synthesis underwent rapid phosphorylation changes during this stage. Whereas the degree of phosphorylation of ribonuclease Rne/Rng (SACE_1406/NC_009142_1388) increased during the metabolic switch, that of two ribosomal proteins, S6 (SACE_7351/NC_009142_7233) and S32 (SACE_6101/NC_009142_5981), dramatically decreased during this stage of the fermentation, supporting the hypothesis that ribosome subpopulations differentially regulate translation before and after the metabolic switch. Overall, we show the great potential of phosphoproteomic studies to explain microbial physiology and specifically provide evidence of dynamic protein phosphorylation events across the developmental cycle of actinomycetes. PMID:24615062

Fretting wear of iron, nickel, and titanium under varied environmental conditions

NASA Technical Reports Server (NTRS)

Bill, R. C.

1979-01-01

Fretting wear experiments were conducted on high-purity iron, nickel and titanium in air under conditions of varied humidity and temperature, and in nitrogen. For iron and titanium, maximum fretting occurred at 10 and 30 percent relative humidity respectively. Nickel showed a minimum in fretting wear at about 10% relative humidity. With increasing temperature, all three metals initially showed reduced fretting wear, with increasing wear observed as temperatures increased beyond 200-300 C. For titanium, dramatically reduced fretting wear was observed at temperatures above 500 C, relatable to a change in oxidation kinetics. All three metals showed much less fretting wear in N2 with the presence of moisture in N2 having a proportionally stronger effect than in air.

Fretting wear of iron, nickel, and titanium under varied environmental conditions

NASA Technical Reports Server (NTRS)

Bill, R. C.

1978-01-01

Fretting wear experiments were conducted on high purity iron, nickel and titanium in air under conditions of varied humidity and temperature, and in nitrogen. For iron and titanium, maximum fretting occurred at 10 and 30 percent relative humidity respectively. Nickel showed a minimum in fretting wear at about 10 percent relative humidity. With increasing temperature, all three metals initially showed reduced fretting wear, with increasing wear observed as temperatures increased beyond 200-300 C. For titanium, dramatically reduced fretting wear was observed at temperatures above 500 C, relatable to a change in oxidation kinetics. All three metals showed much less fretting wear in N2 with the presence of moisture in N2 having a proportionally stronger effect than in air.

Monitoring urban growth and detection of land use with GIS and remote sensing: a case study of the Kyrenia region

NASA Astrophysics Data System (ADS)

Kara, Can; Akçit, Nuhcan

2016-08-01

Land-cover change is considered one of the central components in current strategies for managing natural resources and monitoring environmental changes. It is important to manage land resources in a sustainable manner which targets at compacting and consolidating urban development. From 2005 to 2015,urban growth in Kyrenia has been quite dramatic, showing a wide and scattered pattern, lacking proper plan. As a result of this unplanned/unorganized expansion, agricultural areas, vegetation and water bodies have been lost in the region. Therefore, it has become a necessity to analyze the results of this urban growth and compare the losses between land-cover changes. With this goal in mind, a case study of Kyrenia region has been carried out using a supervised image classification method and Landsat TM images acquired in 2005 and 2015 to map and extract land-cover changes. This paper tries to assess urban-growth changes detected in the region by using Remote Sensing and GIS. The study monitors the changes between different land cover types. Also, it shows the urban occupation of primary soil loss and the losses in forest areas, open areas, etc.

From Red Cells to Soft Porous Lubrication

NASA Astrophysics Data System (ADS)

Wu, Qianhong; Gacka, Thomas; Nathan, Rungun; Crawford, Robert; Vucbmss Team

2014-11-01

Biological scientists have wondered, since the motion of red cells was first observed in capillaries, how the highly flexible red cell can move with so little friction in tightly fitting microvessels without being damaged or undergoing hemolysis. Theoretical studies (Feng and Weinbaum, 2000, JFM; Wu et al., 2004, PRL) attributed this frictionless motion to the dramatically enhanced hydrodynamic lifting force generated inside the soft, porous, endothelial surface layer (ESL) covering the inner surfaces of our capillaries, as a red blood cell glides over it. Herein we report the first experimental examination of this concept. The results conclusively demonstrate that significant fraction of the overall lifting force generated in a soft porous layer as a planing surface glides over it, is contributed by the pore fluid pressure, and thus frictional loss is reduced significantly. Moreover, the experimental predictions showed excellent agreement with the experimental data. This finding has the potential of dramatically changing existing lubrication approaches, and can result in substantial savings in energy consumption and thus reduction in greenhouse gas emissions.

Atmospheric drying as the main driver of dramatic glacier wastage in the southern Indian Ocean

PubMed Central

Favier, V.; Verfaillie, D.; Berthier, E.; Menegoz, M.; Jomelli, V.; Kay, J. E.; Ducret, L.; Malbéteau, Y.; Brunstein, D.; Gallée, H.; Park, Y.-H.; Rinterknecht, V.

2016-01-01

The ongoing retreat of glaciers at southern sub-polar latitudes is particularly rapid and widespread. Akin to northern sub-polar latitudes, this retreat is generally assumed to be linked to warming. However, no long-term and well-constrained glacier modeling has ever been performed to confirm this hypothesis. Here, we model the Cook Ice Cap mass balance on the Kerguelen Islands (Southern Indian Ocean, 49°S) since the 1850s. We show that glacier wastage during the 2000s in the Kerguelen was among the most dramatic on Earth. We attribute 77% of the increasingly negative mass balance since the 1960s to atmospheric drying associated with a poleward shift of the mid-latitude storm track. Because precipitation modeling is very challenging for the current generation of climate models over the study area, models incorrectly simulate the climate drivers behind the recent glacier wastage in the Kerguelen. This suggests that future glacier wastage projections should be considered cautiously where changes in atmospheric circulation are expected. PMID:27580801

Changing Families, Changing Workplaces

ERIC Educational Resources Information Center

Bianchi, Suzanne M.

2011-01-01

American families and workplaces have both changed dramatically over the past half-century. Paid work by women has increased sharply, as has family instability. Education-related inequality in work hours and income has grown. These changes, says Suzanne Bianchi, pose differing work-life issues for parents at different points along the income…

Ecuador's Higher Education System in Times of Change

ERIC Educational Resources Information Center

Van Hoof, Hubert B.; Estrella, Mateo; Eljuri, Marie-Isabel; León, Leonardo Torres

2013-01-01

Ecuador's higher education system is undergoing dramatic changes. The National Constitution of 2008 and the Higher Education Law of 2010 have changed the way Ecuador's universities are funded, administered, and accredited. The importance of research was elevated and drastic changes were made to the academic qualifications and employment conditions…

Social Change and Fathering: Change or Continuity in Vietnam?

ERIC Educational Resources Information Center

Jayakody, Rukmalie; Phuong, Pham Thi Thu

2013-01-01

Dramatic social changes have restructured virtually all aspects of Vietnam society. Although the economic consequences of these changes are well documented, little is known about how family roles and relationships have been affected. Because social and cultural contexts powerfully shape conceptions of parenting, the accelerated rate of social…

Hydrogeochemical and lake level changes in the Ethiopian Rift

NASA Astrophysics Data System (ADS)

Alemayehu, Tamiru; Ayenew, Tenalem; Kebede, Seifu

2006-01-01

The Ethiopian Rift is characterized by a chain of lakes varying in size, hydrological and hydrogeological settings. The rift lakes and feeder rivers are used for irrigation, soda extraction, commercial fish farming and recreation, and support a wide variety of endemic birds and wild animals. The level of some lakes shows dramatic changes in the last few decades. Lakes Abiyata and Beseka, both heavily impacted by human activities, show contrasting lake level trends: the level of Abiyata has dropped by about 5 m over three decades while Beseka has expanded from an area of 2.5-40 km 2 over the same span of time. Changes in lake levels are accompanied by dilution in ionic concentration of lake Beseka and increase in salinity of lake Abiyata. Although the principal hydrogeochemical process in the rift lakes is controlled by the input and output conditions and carbonate precipitation, anthropogenic factors such as water diversion for irrigation and soda ash extraction played important role. The recent changes appear to have grave environmental consequences on the fragile rift ecosystem, which demands an integrated basin-wide water management practice. This paper demonstrates the drastic changes of lake levels and associated changes in lake chemistry of the two studied lakes. It also gives the regional hydrogeochemical picture of the other rift lakes that do not show significant response due to climate change and human impact.

Folgen des Globalen Wandels für das Grundwasser in Süddeutschland - Teil 2: Sozioökonomische Aspekte

NASA Astrophysics Data System (ADS)

Barthel, Roland; Krimly, Tatjana; Elbers, Michael; Soboll, Anja; Wackerbauer, Johann; Hennicker, Rolf; Janisch, Stephan; Reichenau, Tim G.; Dabbert, Stephan; Schmude, Jürgen; Ernst, Andreas; Mauser, Wolfram

2011-12-01

In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube (www.glowa-danube.de) has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article describes part 2 of an article series with investigations of socio-economic aspects, while part 1 (Barthel et al. in Grundwasser 16(4), doi:10.1007/s007-011-01794, 2011) deals with natural-spatial aspects. The principles of socio-economic actor-modeling and interactions between socio-economic and natural science model components are described here. We present selected simulations that show impacts on groundwater from changes in agriculture, tourism, economy, domestic water users and water supply. Despite decreases in water consumption, the scenario simulations show significant decreases in groundwater quantity. On the other hand, groundwater quality will likely be influenced more severely by land use changes compared to direct climatic causes. However, overall changes will not be dramatic.

Changing times, changing stories: Generational differences in climate change perspectives from four remote indigenous communities in Subarctic Alaska

Treesearch

Nicole M. Herman-Mercer; Elli Matkin; Melinda J. Laituri; Ryan C. Toohey; Maggie Massey; Kelly Elder; Paul F. Schuster; Edda A. Mutter

2016-01-01

Indigenous Arctic and Subarctic communities currently are facing a myriad of social and environmental changes. In response to these changes, studies concerning indigenous knowledge (IK) and climate change vulnerability, resiliency, and adaptation have increased dramatically in recent years. Risks to lives and livelihoods are often the focus of adaptation...

Gravity and antigravity in a brane world with metastable gravitons

NASA Astrophysics Data System (ADS)

Gregory, R.; Rubakov, V. A.; Sibiryakov, S. M.

2000-09-01

In the framework of a five-dimensional three-brane model with quasi-localized gravitons we evaluate metric perturbations induced on the positive tension brane by matter residing thereon. We find that at intermediate distances, the effective four-dimensional theory coincides, up to small corrections, with General Relativity. This is in accord with Csaki, Erlich and Hollowood and in contrast to Dvali, Gabadadze and Porrati. We show, however, that at ultra-large distances this effective four-dimensional theory becomes dramatically different: conventional tensor gravity changes into scalar anti-gravity.

Birth of a Pulsar Wind Nebula in SN 1970G

NASA Astrophysics Data System (ADS)

Milisavljevic, Dan

2016-09-01

Chandra observations of the Type IIL supernova SN1970G obtained in 2011 showed a dramatic re-brightening in its X-ray luminosity. This sudden change contrasted starkly with radio emissions that have declined in strength throughout the supernova's lifetime. We request a modest investment of Chandra time to test our hypothesis that this combination of emission properties is associated with a newly formed pulsar wind nebula. We also request three hours of VLA time to look for possible late-time SN-CSM interaction and to fully characterize the nature of the emission.

Entropy in the interior of a higher-dimensional black hole

NASA Astrophysics Data System (ADS)

Yang, Jian-Zhi; Liu, Wen-Biao

2018-07-01

Recently Christodoulou and Rovelli brought out a sensible description for the black hole volume as the largest volume. Later the entropy related to this volume in a 4-dimensional Schwarzschild black hole was investigated, which showed that such entropy is proportional to the surface area of the black hole. We will probe into these issues in the context of higher-dimensional case. It is found that the proportion between this entropy and the Bekenstein-Hawking entropy will go down through dramatic change along with the increase of spacetime dimension.

Game-Changing Innovations: How Culture Can Change the Parameters of Its Own Evolution and Induce Abrupt Cultural Shifts.

PubMed

Kolodny, Oren; Creanza, Nicole; Feldman, Marcus W

2016-12-01

One of the most puzzling features of the prehistoric record of hominid stone tools is its apparent punctuation: it consists of abrupt bursts of dramatic change that separate long periods of largely unchanging technology. Within each such period, small punctuated cultural modifications take place. Punctuation on multiple timescales and magnitudes is also found in cultural trajectories from historical times. To explain these sharp cultural bursts, researchers invoke such external factors as sudden environmental change, rapid cognitive or morphological change in the hominids that created the tools, or replacement of one species or population by another. Here we propose a dynamic model of cultural evolution that accommodates empirical observations: without invoking external factors, it gives rise to a pattern of rare, dramatic cultural bursts, interspersed by more frequent, smaller, punctuated cultural modifications. Our model includes interdependent innovation processes that occur at different rates. It also incorporates a realistic aspect of cultural evolution: cultural innovations, such as those that increase food availability or that affect cultural transmission, can change the parameters that affect cultural evolution, thereby altering the population's cultural dynamics and steady state. This steady state can be regarded as a cultural carrying capacity. These parameter-changing cultural innovations occur very rarely, but whenever one occurs, it triggers a dramatic shift towards a new cultural steady state. The smaller and more frequent punctuated cultural changes, on the other hand, are brought about by innovations that spur the invention of further, related, technology, and which occur regardless of whether the population is near its cultural steady state. Our model suggests that common interpretations of cultural shifts as evidence of biological change, for example the appearance of behaviorally modern humans, may be unwarranted.

Game-Changing Innovations: How Culture Can Change the Parameters of Its Own Evolution and Induce Abrupt Cultural Shifts

PubMed Central

2016-01-01

One of the most puzzling features of the prehistoric record of hominid stone tools is its apparent punctuation: it consists of abrupt bursts of dramatic change that separate long periods of largely unchanging technology. Within each such period, small punctuated cultural modifications take place. Punctuation on multiple timescales and magnitudes is also found in cultural trajectories from historical times. To explain these sharp cultural bursts, researchers invoke such external factors as sudden environmental change, rapid cognitive or morphological change in the hominids that created the tools, or replacement of one species or population by another. Here we propose a dynamic model of cultural evolution that accommodates empirical observations: without invoking external factors, it gives rise to a pattern of rare, dramatic cultural bursts, interspersed by more frequent, smaller, punctuated cultural modifications. Our model includes interdependent innovation processes that occur at different rates. It also incorporates a realistic aspect of cultural evolution: cultural innovations, such as those that increase food availability or that affect cultural transmission, can change the parameters that affect cultural evolution, thereby altering the population’s cultural dynamics and steady state. This steady state can be regarded as a cultural carrying capacity. These parameter-changing cultural innovations occur very rarely, but whenever one occurs, it triggers a dramatic shift towards a new cultural steady state. The smaller and more frequent punctuated cultural changes, on the other hand, are brought about by innovations that spur the invention of further, related, technology, and which occur regardless of whether the population is near its cultural steady state. Our model suggests that common interpretations of cultural shifts as evidence of biological change, for example the appearance of behaviorally modern humans, may be unwarranted. PMID:28036346

Infrared and swelling study of the hydration-induced phase transition of wet-spun hyaluronate films

NASA Astrophysics Data System (ADS)

Hoppe, A. D.; Marlowe, R. L.; Lee, S. A.; Powell, J. W.; Rupprecht, A.

1997-03-01

The hydration properties of wet-spun films of hyaluronate (HA) with four different counterions (Li^+, Cs^+, Mg^2+, and Ca^2+) have been studied using optical microscopy, optical birefringence and infrared (IR) spectroscopy. Small pieces of these films were found to be optically birefringent up to hydration levels near 90 % relative humidity (RH). All four kinds of films then became optically isotropic and display dramatic changes in size. These changes are consistent with the occurrence of an order-disorder (o-d) transition. IR spectroscopy of the backbone region (from 800 to 1000 cm-1) suggests that the Li^+, Cs^+ and Ca^2+ films are very similar. Two IR bands in this region are observed at low RH and show no dependence on hydration until the o-d transition. The IR spectra of CaHA show five bands in this region. These five bands are observed to 95 % RH.

It's a trap! Clinical similarities and subtle ECG differences between takotsubo cardiomyopathy and myocardial infarction.

PubMed

Vivo, Rey P; Krim, Selim R; Hodgson, John

2008-11-01

We describe a 65-year-old woman with a history of hypertension and smoking who presented with an acute episode of chest pain precipitated by severe emotional stress. Her initial electrocardiogram done in the emergency room showed non-specific T wave changes in the lateral leads and her cardiac troponin levels were mildly elevated. Because of her clinical presentation, she was admitted with a presumptive diagnosis of acute myocardial infarction and managed with antiplatelet and anticoagulant therapy. Coronary angiogram did not reveal coronary artery disease and left ventriculography showed findings consistent with apical ballooning syndrome or takotsubo cardiomyopathy. Subsequent electrocardiograms displayed dramatic changes including T wave inversions, QT interval prolongation and U waves. The patient remained asymptomatic and recovered uneventfully. Three weeks post-discharge, an echocardiogram documented resolved left ventricular dysfunction. We describe the clinical features and highlight the electrocardiographic findings that may help differentiate takotsubo cardiomyopathy from myocardial infarction.

Trends in Spouses’ Shared Time in the United States, 1965–2012

PubMed Central

Genadek, Katie R.; Flood, Sarah M.; Roman, Joan Garcia

2016-01-01

Despite major demographic changes over the past 50 years and strong evidence that time spent with a spouse is important for marriages, we know very little about how time with a spouse has changed—or not—in the United States. Using time diary data from 1965–2012, we examine trends in couples’ shared time in the United States during a period of major changes in American marriages and families. We find that couples without children spent more total time together and time alone together n 2012 than they did in 1965, with total time and time alone together both peaking in 1975. For parents, time spent together increased between 1965 and 2012, most dramatically for time spent with a spouse and children. Decomposition analyses show that changes in behavior rather than changing demographics explain these trends, and we find that the increases in couples’ shared time are primarily concentrated in leisure activities. PMID:27730493

GABAB receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation

PubMed Central

Ainsworth, Matthew; Lee, Shane; Kaiser, Marcus; Simonotto, Jennifer; Kopell, Nancy J.

2016-01-01

Repeated presentations of sensory stimuli generate transient gamma-frequency (30–80 Hz) responses in neocortex that show plasticity in a task-dependent manner. Complex relationships between individual neuronal outputs and the mean, local field potential (population activity) accompany these changes, but little is known about the underlying mechanisms responsible. Here we show that transient stimulation of input layer 4 sufficient to generate gamma oscillations induced two different, lamina-specific plastic processes that correlated with lamina-specific changes in responses to further, repeated stimulation: Unit rates and recruitment showed overall enhancement in supragranular layers and suppression in infragranular layers associated with excitatory or inhibitory synaptic potentiation onto principal cells, respectively. Both synaptic processes were critically dependent on activation of GABAB receptors and, together, appeared to temporally segregate the cortical representation. These data suggest that adaptation to repetitive sensory input dramatically alters the spatiotemporal properties of the neocortical response in a manner that may both refine and minimize cortical output simultaneously. PMID:27118845

GABAB receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation.

PubMed

Ainsworth, Matthew; Lee, Shane; Kaiser, Marcus; Simonotto, Jennifer; Kopell, Nancy J; Whittington, Miles A

2016-05-10

Repeated presentations of sensory stimuli generate transient gamma-frequency (30-80 Hz) responses in neocortex that show plasticity in a task-dependent manner. Complex relationships between individual neuronal outputs and the mean, local field potential (population activity) accompany these changes, but little is known about the underlying mechanisms responsible. Here we show that transient stimulation of input layer 4 sufficient to generate gamma oscillations induced two different, lamina-specific plastic processes that correlated with lamina-specific changes in responses to further, repeated stimulation: Unit rates and recruitment showed overall enhancement in supragranular layers and suppression in infragranular layers associated with excitatory or inhibitory synaptic potentiation onto principal cells, respectively. Both synaptic processes were critically dependent on activation of GABAB receptors and, together, appeared to temporally segregate the cortical representation. These data suggest that adaptation to repetitive sensory input dramatically alters the spatiotemporal properties of the neocortical response in a manner that may both refine and minimize cortical output simultaneously.

Living on the Edge: Parasite Prevalence Changes Dramatically across a Range Edge in an Invasive Gecko.

PubMed

Coates, Andrew; Barnett, Louise K; Hoskin, Conrad; Phillips, Ben L

2017-02-01

Species interactions can determine range limits, and parasitism is the most intimate of such interactions. Intriguingly, the very conditions on range edges likely change host-parasite dynamics in nontrivial ways. Range edges are often associated with clines in host density and with environmental transitions, both of which may affect parasite transmission. On advancing range edges, founder events and fitness/dispersal costs of parasitism may also cause parasites to be lost on range edges. Here we examine the prevalence of three species of parasite across the range edge of an invasive gecko, Hemidactylus frenatus, in northeastern Australia. The gecko's range edge spans the urban-woodland interface at the edge of urban areas. Across this edge, gecko abundance shows a steep decline, being lower in the woodland. Two parasite species (a mite and a pentastome) are coevolved with H. frenatus, and these species become less prevalent as the geckos become less abundant. A third species of parasite (another pentastome) is native to Australia and has no coevolutionary history with H. frenatus. This species became more prevalent as the geckos become less abundant. These dramatic shifts in parasitism (occurring over 3.5 km) confirm that host-parasite dynamics can vary substantially across the range edge of this gecko host.

Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder.

PubMed

Zhu, Shanshan; Cordner, Zachary A; Xiong, Jiali; Chiu, Chi-Tso; Artola, Arabiye; Zuo, Yanning; Nelson, Andrew D; Kim, Tae-Yeon; Zaika, Natalya; Woolums, Brian M; Hess, Evan J; Wang, Xiaofang; Chuang, De-Maw; Pletnikov, Mikhail M; Jenkins, Paul M; Tamashiro, Kellie L; Ross, Christopher A

2017-09-26

Genome-wide association studies have implicated the ANK3 locus in bipolar disorder, a major human psychotic illness. ANK3 encodes ankyrin-G, which organizes the neuronal axon initial segment (AIS). We generated a mouse model with conditional disruption of ANK3 in pyramidal neurons of the adult forebrain (Ank-G cKO). This resulted in the expected loss of pyramidal neuron AIS voltage-gated sodium and potassium channels. There was also dramatic loss of markers of afferent GABAergic cartridge synapses, resembling the cortical microcircuitry changes in brains from psychotic patients, and suggesting disinhibition. Expression of c-fos was increased in cortical pyramidal neurons, consistent with increased neuronal activity due to disinhibition. The mice showed robust behavioral phenotypes reminiscent of aspects of human mania, ameliorated by antimania drugs lithium and valproate. Repeated social defeat stress resulted in repeated episodes of dramatic behavioral changes from hyperactivity to "depression-like" behavior, suggestive of some aspects of human bipolar disorder. Overall, we suggest that this Ank-G cKO mouse model recapitulates some of the core features of human bipolar disorder and indicates that cortical microcircuitry alterations during adulthood may be involved in pathogenesis. The model may be useful for studying disease pathophysiology and for developing experimental therapeutics.

Changing America and the Changing Image of Scottsboro

ERIC Educational Resources Information Center

Murray, Hugh T., Jr.

1977-01-01

Discusses literary representations of Scottsboro. Notes that "the content of the extensive literature of Scottsboro changed dramatically, reflecting the radicalism of the 1930's, the cold-war liberalism of the 1950's, and the vacillations of the late 1960's early 70's. (Author/JM)

A young-onset frontal dementia with dramatic calcifications due to a novel CSF1R mutation.

PubMed

Gore, Ethan; Manley, Andrew; Dees, Daniel; Appleby, Brian S; Lerner, Alan J

2016-06-01

Neuroimaging and genomic analysis greatly aid in the identification of young-onset dementia antemortem. We present the case of a 33-year-old female with a 2-year rapid decline to dementia and immobility marked by personality change, executive deficits including compulsions, attention deficit, apraxia, Parkinsonism, and pyramidal signs. She had unique and dramatic calcifications and confluent white matter changes on imaging and was found to have a novel mutation in the colony stimulating factor 1 receptor gene causing adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Here, we review ALSP and briefly discuss differential diagnoses.

Morphological evolution, ecological diversification and climate change in rodents.

PubMed

Renaud, Sabrina; Michaux, Jacques; Schmidt, Daniela N; Aguilar, Jean-Pierre; Mein, Pierre; Auffray, Jean-Christophe

2005-03-22

Among rodents, the lineage from Progonomys hispanicus to Stephanomys documents a case of increasing size and dental specialization during an approximately 9 Myr time-interval. On the contrary, some contemporaneous generalist lineages like Apodemus show a limited morphological evolution. Dental shape can be related to diet and can be used to assess the ecological changes along the lineages. Consequently, size and shape of the first upper molar were measured in order to quantify the patterns of morphological evolution along both lineages and compare them to environmental trends. Climatic changes do not have a direct influence on evolution, but they open new ecological opportunities by changing vegetation and allow the evolution of a specialist like Stephanomys. On the other hand, environmental changes are not dramatic enough to destroy the habitat of a long-term generalist like Apodemus. Hence, our results exemplify a case of an influence of climate on the evolution of specialist species, although a generalist species may persist without change.

Morphological evolution, ecological diversification and climate change in rodents

PubMed Central

Renaud, Sabrina; Michaux, Jacques; Schmidt, Daniela N; Aguilar, Jean-Pierre; Mein, Pierre; Auffray, Jean-Christophe

2005-01-01

Among rodents, the lineage from Progonomys hispanicus to Stephanomys documents a case of increasing size and dental specialization during an approximately 9 Myr time-interval. On the contrary, some contemporaneous generalist lineages like Apodemus show a limited morphological evolution. Dental shape can be related to diet and can be used to assess the ecological changes along the lineages. Consequently, size and shape of the first upper molar were measured in order to quantify the patterns of morphological evolution along both lineages and compare them to environmental trends. Climatic changes do not have a direct influence on evolution, but they open new ecological opportunities by changing vegetation and allow the evolution of a specialist like Stephanomys. On the other hand, environmental changes are not dramatic enough to destroy the habitat of a long-term generalist like Apodemus. Hence, our results exemplify a case of an influence of climate on the evolution of specialist species, although a generalist species may persist without change. PMID:15817435

Communicating climate change and health in the media.

PubMed

Depoux, Anneliese; Hémono, Mathieu; Puig-Malet, Sophie; Pédron, Romain; Flahault, Antoine

2017-01-01

The translation of science from research to real-world change is a central goal of public health. Communication has an essential role to play in provoking a response to climate change. It must first raise awareness, make people feel involved and ultimately motivate them to take action. The goal of this research is to understand how the information related to this issue is being addressed and disseminated to different audiences-public citizens, politicians and key climate change stakeholders. Initial results show that the scientific voice struggles to globally highlight this issue to a general audience and that messages that address the topic do not meet the challenges, going from a dramatic framing to a basic adaptation framing. Communication experts can help inform scientists and policy makers on how to best share information about climate change in an engaging and motivating way. This study gives an insight about the key role of the media and communications in addressing themes relating to climate change and transmitting information to the public in order to take action.

Changing Times: A Changing Public Sector May Require Changes to Public Management Education Programmes

ERIC Educational Resources Information Center

Oldfield, Chrissie

2017-01-01

It is becoming apparent that the environment in which Executive Masters in Public Administration programmes operate has changed dramatically in the wake of economic crisis and subsequent cuts in public spending. Changes in the funding of public sector organisations has been compounded by a broader "crisis" in the wider public sector…

New Mexico Community Health Councils: Documenting Contributions to Systems Changes.

PubMed

Sánchez, Victoria; Andrews, Mark L; Carrillo, Christina; Hale, Ron

2015-01-01

Coalition research has shifted from delineating structures and processes to identifying intermediate, systems changes (e.g., changes in policies) that contribute to longterm community health improvement. The University of New Mexico, the New Mexico Department of Health, and community health councils entered a multiyear participatory evaluation process to answer: What actions did health councils take that led to improving health through intermediate, systems changes? The evaluation system was created over several phases through an iterative, participatory process. Data were collected for councils' health priority areas (e.g., substance abuse) from 2009 to 2011. Twenty-three community health councils participated. Intermediate systems changes were measured: 1) networking and partnering, 2) joint planning of strategies, programs, and services, 3) leveraging resources, and 4) policy initiatives. Health councils reported data for each intermediate outcome by health priority area. Data showed councils identified local public health priorities and addressed those priorities through strengthening networks and partnerships, which lead to the creation and enhancement of strategies, services, and programs. Data also showed councils influenced policies in several ways (e.g., developing policy, identifying new policy, or sponsoring informational forums). Additionally, data showed councils leveraged $1.10 for every dollar invested by the state. When funding was suspended in July 2010, data showed dramatic decreases in activity levels from 2010 to 2011. The data demonstrate the feasibility and utility of an Internet-based system designed to gather intermediate systems changes evaluation data. This process is a model for similar efforts to capture common outcomes across diverse coalitions and partnerships.

University Outreach and Engagement: Responding to a Changing World

ERIC Educational Resources Information Center

Hrabowski, Freeman A., III; Weidemann, Craig D.

2004-01-01

Rapid and dramatic demographic and technological changes present the nation with enormous challenges for educating students, growing the economy, and responding to society's needs. America's colleges and universities have a central role to play in all of these critical areas--serving as agents of change as they themselves change institutionally in…

Interactions of climate change with biological invasions and land use in the Hawaiian Islands: Modeling the fate of endemic birds using a geographic information system.

PubMed

Benning, Tracy L; LaPointe, Dennis; Atkinson, Carter T; Vitousek, Peter M

2002-10-29

The Hawaiian honeycreepers (Drepanidae) represent a superb illustration of evolutionary radiation, with a single colonization event giving rise to 19 extant and at least 10 extinct species [Curnutt, J. & Pimm, S. (2001) Stud. Avian Biol. 22, 15-30]. They also represent a dramatic example of anthropogenic extinction. Crop and pasture land has replaced their forest habitat, and human introductions of predators and diseases, particularly of mosquitoes and avian malaria, has eliminated them from the remaining low- and mid-elevation forests. Landscape analyses of three high-elevation forest refuges show that anthropogenic climate change is likely to combine with past land-use changes and biological invasions to drive several of the remaining species to extinction, especially on the islands of Kauai and Hawaii.

Mesoscale evolution of voids and microstructural changes in HMX-based explosives during heating through the β-δ phase transition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willey, Trevor M., E-mail: willey1@llnl.gov; Lauderbach, Lisa; Gagliardi, Franco

HMX-based explosives LX-10 and PBX-9501 were heated through the β-δ phase transition. Ultra-small angle x-ray scattering (USAXS) and molecular diffraction were simultaneously recorded as the HMX was heated. Mesoscale voids and structure dramatically change promptly with the β-δ phase transition, rather than with other thermal effects. Also, x-ray induced damage, observed in the USAXS, occurs more readily at elevated temperatures; as such, the dose was reduced to mitigate this effect. Optical microscopy performed during a similar heating cycle gives an indication of changes on longer length scales, while x-ray microtomography, performed before and after heating, shows the character of extensivemore » microstructural damage resulting from the temperature cycle and solid-state phase transition.« less

Mesoscale evolution of voids and microstructural changes in HMX-based explosives during heating through the β-δ phase transition

DOE PAGES

Willey, Trevor M.; Lauderbach, Lisa; Gagliardi, Franco; ...

2015-08-07

HMX-based explosives LX-10 and PBX-9501 were heated through the β-δ phase transition. Ultra-small angle x-ray scattering (USAXS) and molecular diffraction were simultaneously recorded as the HMX was heated. Mesoscale voids and structure dramatically change promptly with the β-δ phase transition, rather than with other thermal effects. Also, x-ray induced damage, observed in the USAXS, occurs more readily at elevated temperatures; as such, the dose was reduced to mitigate this effect. Optical microscopy performed during a similar heating cycle gives an indication of changes on longer length scales, while x-ray microtomography, performed before and after heating, shows the character of extensivemore » microstructural damage resulting from the temperature cycle and solid-state phase transition.« less

Interactions of climate change with biological invasions and land use in the Hawaiian Islands: Modeling the fate of endemic birds using a geographic information system

PubMed Central

Benning, Tracy L.; LaPointe, Dennis; Atkinson, Carter T.; Vitousek, Peter M.

2002-01-01

The Hawaiian honeycreepers (Drepanidae) represent a superb illustration of evolutionary radiation, with a single colonization event giving rise to 19 extant and at least 10 extinct species [Curnutt, J. & Pimm, S. (2001) Stud. Avian Biol. 22, 15–30]. They also represent a dramatic example of anthropogenic extinction. Crop and pasture land has replaced their forest habitat, and human introductions of predators and diseases, particularly of mosquitoes and avian malaria, has eliminated them from the remaining low- and mid-elevation forests. Landscape analyses of three high-elevation forest refuges show that anthropogenic climate change is likely to combine with past land-use changes and biological invasions to drive several of the remaining species to extinction, especially on the islands of Kauai and Hawaii. PMID:12374870

An assessment of climate change in the Luquillo Mountains of Puerto Rico.

Treesearch

F. N. Scatena

1998-01-01

Change in the surface temperature of the coastal plain of 1 to 2C and/or a 11 to 33% change in annual rainfall could dramatically alter the distribution of forest vegetation within the Luquillo Experimental Forest(LEF) of northeastern Puerto Rico.

Institutional Influence on Behavioural Disorders in Early Adolescents

ERIC Educational Resources Information Center

Jayalekshmi, N. B.; Raja, B. William Dharma

2014-01-01

Early adolescence a period of transition between childhood and late adolescence, is where one experiences dramatic changes physically, and psychologically. These transitions cause cognitive, emotional, and social changes. The developmental changes that occur during this period cause varying degrees of disturbance in them. The period of transition…

The Changing Landscape of Disability in Childhood

ERIC Educational Resources Information Center

Halfon, Neal; Houtrow, Amy; Larson, Kandyce; Newacheck, Paul W.

2012-01-01

Americans' perceptions of childhood disability have changed dramatically over the past century, as have their ideas about health and illness, medical developments, threats to children's health and development, and expectations for child functioning. Neal Halfon, Amy Houtrow, Kandyce Larson, and Paul Newacheck examine how these changes have…

Global warming: China’s contribution to climate change

NASA Astrophysics Data System (ADS)

Spracklen, Dominick V.

2016-03-01

Carbon dioxide emissions from fossil-fuel use in China have grown dramatically in the past few decades, yet it emerges that the country's relative contribution to global climate change has remained surprisingly constant. See Letter p.357

Southeast Atmosphere Studies Workshop 2015

EPA Science Inventory

Concentrations of atmospheric trace species in the United States have changed dramatically over the past several decades in response to pollution control strategies, shifts in domestic energy policy, and economic development (and resulting emission changes) elsewhere in the world...

Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity

PubMed Central

Luo, Yuhuan; Yu, Xiafei; Ma, Cheng; Luo, Jianhong; Yang, Wei

2018-01-01

As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes. Intracellular calcium is critical for TRPM2 channel activation and the IQ-like motif in the N-terminus has been shown to be important by mediating calmodulin binding. Sequence analysis predicted two potential EF-loops in the N-terminus of TRPM2. Site-directed mutagenesis combining with functional assay showed that substitution with alanine of several residues, most of which are conserved in the typical EF-loop, including D267, D278, D288, and E298 dramatically reduced TRPM2 channel currents. By further changing the charges or side chain length of these conserved residues, our results indicate that the negative charge of D267 and the side chain length of D278 are critical for calcium-induced TRPM2 channel activation. G272I mutation also dramatically reduced the channel currents, suggesting that this site is critical for calcium-induced TRPM2 channel activation. Furthermore, D267A mutant dramatically reduced the currents induced by calcium alone compared with that by ADPR, indicating that D267 residue in D267–D278 motif is the most important site for calcium sensitivity of TRPM2. In addition, inside-out recordings showed that mutations at D267, G272, D278, and E298 had no effect on single-channel conductance. Taken together, our data indicate that D267–D278 motif in the N-terminus as a novel EF-loop is critical for calcium-induced TRPM2 channel activation.

Giant Pressure-Induced Enhancement of Seebeck Coefficient and Thermoelectric Efficiency in SnTe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, Jason; Kumar, Ravhi; Park, Changyong

The thermoelectric properties of polycrystalline SnTe have been measured up to 4.5 GPa at 330 K. SnTe shows an enormous enhancement in Seebeck coefficient, greater than 200 % after 3 GPa, which correlates to a known pressure-induced structural phase transition that is observed through simultaneous in situ X-ray diffraction measurement. We also measured electrical resistance and relative changes to the thermal conductivity, enabling the determination of relative changes in the dimensionless figure of merit (ZT), which increases dramatically after 3 GPa, reaching 350 % of the lowest pressure ZT value. Our results demonstrate a fundamental relationship between structure and thermoelectricmore » behaviours and suggest that pressure is an effective tool to control them.« less

Giant Pressure-Induced Enhancement of Seebeck Coefficient and Thermoelectric Efficiency in SnTe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, Jason; Kumar, Ravhi; Park, Changyong

The thermoelectric properties of polycrystalline SnTe have been measured up to 4.5 GPa at 330 K. SnTe shows an enormous enhancement in Seebeck coefficient, greater than 200 % after 3 GPa, which correlates to a known pressure-induced structural phase transition that is observed through simultaneous in situ X-ray diffraction measurement. Electrical resistance and relative changes to the thermal conductivity were also measured, enabling the determination of relative changes in the dimensionless figure of merit (ZT), which increases dramatically after 3 GPa, reaching 350 % of the lowest pressure ZT value. The results demonstrate a fundamental relationship between structure and thermoelectricmore » behaviours and suggest that pressure is an effective tool to control them.« less

Coherent Radiation in Atomic Systems

NASA Astrophysics Data System (ADS)

Sutherland, Robert Tyler

Over the last century, quantum mechanics has dramatically altered our understanding of light and matter. Impressively, exploring the relationship between the two continues to provide important insights into the physics of many-body systems. In this thesis, we add to this still growing field of study. Specifically, we discuss superradiant line-broadening and cooperative dipole-dipole interactions for cold atom clouds in the linear-optics regime. We then discuss how coherent radiation changes both the photon scattering properties and the excitation distribution of atomic arrays. After that, we explore the nature of superradiance in initially inverted clouds of multi-level atoms. Finally, we explore the physics of clouds with degenerate Zeeman ground states, and show that this creates quantum effects that fundamentally change the photon scattering of atomic ensembles.

Business, society, and the Reagan revolution.

PubMed

Post, J E

1983-01-01

When Ronald Reagan first came to power two years ago, many Americans believed that his administration would bring about dramatic and fundamental changes in American politics. In this paper, the author contends that although it is still too early to fully assess the effects of "Reaganism" on the country in general, it is not too early to evaluate the results in terms of the altered relationships between government, business, and society. The author goes on to say that the 1982 congressional election results already show that the American people are fast becoming disillusioned with the Reagan administration. In conclusion, the author maintains that only when the U.S. chooses a visionary leader who is capable of defining--or redefining--"progress." will American politics undergo a real revolutionary change.

Giant Pressure-Induced Enhancement of Seebeck Coefficient and Thermoelectric Efficiency in SnTe

DOE PAGES

Baker, Jason; Kumar, Ravhi; Park, Changyong; ...

2017-10-30

The thermoelectric properties of polycrystalline SnTe have been measured up to 4.5 GPa at 330 K. SnTe shows an enormous enhancement in Seebeck coefficient, greater than 200 % after 3 GPa, which correlates to a known pressure-induced structural phase transition that is observed through simultaneous in situ X-ray diffraction measurement. We also measured electrical resistance and relative changes to the thermal conductivity, enabling the determination of relative changes in the dimensionless figure of merit (ZT), which increases dramatically after 3 GPa, reaching 350 % of the lowest pressure ZT value. Our results demonstrate a fundamental relationship between structure and thermoelectricmore » behaviours and suggest that pressure is an effective tool to control them.« less

Patagonia Glacier, Chile

NASA Image and Video Library

2001-07-21

This ASTER image was acquired on May 2, 2000 over the North Patagonia Ice Sheet, Chile near latitude 47 degrees south, longitude 73 degrees west. The image covers 36 x 30 km. The false color composite displays vegetation in red. The image dramatically shows a single large glacier, covered with crevasses. A semi-circular terminal moraine indicates that the glacier was once more extensive than at present. ASTER data are being acquired over hundreds of glaciers worldwide to measure their changes over time. Since glaciers are sensitive indicators of warming or cooling, this program can provide global data set critical to understand climate change. This image is located at 46.5 degrees south latitude and 73.9 degrees west longitude. http://photojournal.jpl.nasa.gov/catalog/PIA02670

7000 years of Emiliania huxleyi viruses in the Black Sea.

PubMed

Coolen, Marco J L

2011-07-22

A 7000-year record of Coccolithovirus and its host, the calcifying haptophyte Emiliania huxleyi, was reconstructed on the basis of genetic signatures preserved in sediments underlying the Black Sea. The data show that the same virus and host populations can persist for centuries. Major changes in virus and host populations occurred during early sapropel deposition, ~5600 years ago, and throughout the formation of the coccolith-bearing sediments of Unit I during the past 2500 years, when the Black Sea experienced dramatic changes in hydrologic and nutrient regimes. Unit I saw a reoccurrence of the same host genotype thousands of years later in the presence of a different subset of viruses. Historical plankton virus populations can thus be included in paleoecological and paleoenvironmental studies.

Exploring Lyric, Epic, and Dramatic Voices: Stages of Incandescence in the Poetry of the Aged.

ERIC Educational Resources Information Center

Reed, M. Ann

1992-01-01

Identifies true relationships between the psyche and the lyric, epic, and dramatic voices of poetry. Shows how the acts of identifying, responding to, and composing in these three voices engage healing, inspiration, and active imagination among the aging. (SR)

Patterns of gene expression in atrophying skeletal muscles: response to food deprivation

NASA Technical Reports Server (NTRS)

Jagoe, R. Thomas; Lecker, Stewart H.; Gomes, Marcelo; Goldberg, Alfred L.

2002-01-01

During fasting and many systemic diseases, muscle undergoes rapid loss of protein and functional capacity. To define the transcriptional changes triggering muscle atrophy and energy conservation in fasting, we used cDNA microarrays to compare mRNAs from muscles of control and food-deprived mice. Expression of >94% of genes did not change, but interesting patterns emerged among genes that were differentially expressed: 1) mRNAs encoding polyubiquitin, ubiquitin extension proteins, and many (but not all) proteasome subunits increased, which presumably contributes to accelerated protein breakdown; 2) a dramatic increase in mRNA for the ubiquitin ligase, atrogin-1, but not most E3s; 3) a significant suppression of mRNA for myosin binding protein H (but not other myofibrillar proteins) and IGF binding protein 5, which may favor cell protein loss; 4) decreases in mRNAs for several glycolytic enzymes and phosphorylase kinase subunits, and dramatic increases in mRNAs for pyruvate dehydrogenase kinase 4 and glutamine synthase, which should promote glucose sparing and gluconeogenesis. During fasting, metallothionein mRNA increased dramatically, mRNAs for extracellular matrix components fell, and mRNAs that may favor cap-independent mRNA translation rose. Significant changes occurred in mRNAs for many growth-related proteins and transcriptional regulators. These transcriptional changes indicate a complex adaptive program that should favor protein degradation and suppress glucose oxidation in muscle. Similar analysis of muscles atrophying for other causes is allowing us to identify a set of atrophy-specific changes in gene expression.

Rectal cancer surgery: a brief history.

PubMed

Galler, Avi S; Petrelli, Nicholas J; Shakamuri, Shanthi P

2011-12-01

In the last 250 years, the treatment of rectal cancer has changed dramatically. Once considered an incurable disease, combined modality therapy has improved mortality from 100% to less than 4% for locally advanced rectal cancer. This dramatic reduction paralleled surgical techniques based on a growing understanding of anatomy and disease pathology. In order to understand modern treatment, it is necessary to recognize the achievements of preceding surgeons. Copyright © 2010 Elsevier Ltd. All rights reserved.

Name Changes in Medically Important Fungi and Their Implications for Clinical Practice

PubMed Central

de Hoog, G. Sybren; Chaturvedi, Vishnu; Denning, David W.; Dyer, Paul S.; Frisvad, Jens Christian; Geiser, David; Gräser, Yvonne; Guarro, Josep; Haase, Gerhard; Kwon-Chung, Kyung-Joo; Meyer, Wieland; Pitt, John I.; Samson, Robert A.; Tintelnot, Kathrin; Vitale, Roxana G.; Walsh, Thomas J.

2014-01-01

Recent changes in the Fungal Code of Nomenclature and developments in molecular phylogeny are about to lead to dramatic changes in the naming of medically important molds and yeasts. In this article, we present a widely supported and simple proposal to prevent unnecessary nomenclatural instability. PMID:25297326

Society Membership Profile: Employment Mobility and Career Change. AIP Report.

ERIC Educational Resources Information Center

Porter, Beverly Fearn; Kellman, Dawn

Information on the influence of employment mobility and career change on the flexibility of the physics labor force is provided, noting the past several decades have brought a dramatic roller coaster of changes to the physics community. Five sections are as follows: membership composition (demographics, professional self-identification, and…

Multiple-scale proximal sensor and remote imagery technology for sustaining agricultural productivity during climate change

USDA-ARS?s Scientific Manuscript database

Changes in climatic patterns have had dramatic influence on agricultural areas worldwide, particularly in irrigated arid-zone agricultural areas subjected to recurring drought, such as California’s San Joaquin Valley. Climate change has impacted water availability, which subsequently has impacted so...

Dangerous Gulf? The Relationship between America and its All-Volunteer Military

DTIC Science & Technology

2013-03-01

altering transformations like finding or converting to a new religion, or even turning Vegan . The pronounced changes brought on by a dramatic change...846961/celebrating- motherhood-how-becoming-a-mom-changes-you (accessed January 14, 2008); Colleen Patrick- Goudreau, “The Joyful Vegan : Stories of

School Business Administration: A Planning Approach. Third Edition.

ERIC Educational Resources Information Center

Candoli, I. Carl; And Others

The school business administration function in the operation of American schools has undergone dramatic changes during the past several years. Changing demographics, high technology, the movement to professionalize school administration, and changes by the legislative and judicial systems have all had significant impact on the character of school…

Changing Roles of Special Education Administrators: Impact on Multicultural Learners

ERIC Educational Resources Information Center

Bakken, Jeffrey P.; O'Brian, Mary; Shelden, Debra L.

2006-01-01

It is imperative for special education administrators, and all administrators, to adapt to the changing demographic and educational environments. The field of special education has changed dramatically in the last three decades, and administrators can and should be leaders of the continued evolution of special education. One useful organizing…

Teaching Tip: Are You Changing the Rules? Again?

ERIC Educational Resources Information Center

Rice, Theodore

2012-01-01

Students often complain that the rules of mathematics are being changed. A short conversation between a professor and a class of college algebra students dramatizes this in the realm of complex numbers and the legal realm of speed limits.

Southeast Atmosphere Studies: learning from model-observation syntheses

EPA Science Inventory

Concentrations of atmospheric trace species in the United States have changed dramatically over the past several decades in response to pollution control strategies, shifts in domestic energy policy and economics, and economic development (and resulting emission changes) elsewher...

THE EFFECT OF PROPRANOLOL ON GENE EXPRESSION DURING THE BLOOD ALCOHOL CYCLE OF RATS FED ETHANOL INTRAGASTRICALLY

PubMed Central

Li, Jun; Bardag-Gorce, F; Joan, Oliva; French, BA; Dedes, J; French, SW

2010-01-01

Propranolol, a beta adrenergic blocker prevents the blood alcohol (BAL) cycle in rats fed ethanol intragastrically at a constant rate by preventing the cyclic changes in the metabolic rate caused by fluctuating levels of norepinephrine released into the blood. The change in the rate of metabolism changes the rate of alcohol elimination in the blood which causes the BAL to cycle. Microarray analysis of the livers from the rats fed ethanol and propranolol showed similar changes in clusters of functionally related gene expressions. The controls and the trough of the cycle differed dramatically from the cluster pattern seen in the rats at the peaks of the blood alcohol cycle. The changes in gene expression induced by ethanol were similar when propranolol was fed without ethanol especially with the changes in the kinases and phosphatases, Toll-like receptor signaling and cytokine-cytokine receptor interaction were also changed. The changes in gene expression caused by ethanol and propranolol feeding are alike probably because both drugs induce β adrenergic receptor desensitization. PMID:19925788

Time dependent changes in Schottky barrier mapping of the W/Si(001) interface utilizing ballistic electron emission microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durcan, Chris A.; Balsano, Robert; LaBella, Vincent P., E-mail: vlabella@albany.edu

2015-06-28

The W/Si(001) Schottky barrier height is mapped to nanoscale dimensions using ballistic electron emission microscopy (BEEM) over a period of 21 days to observe changes in the interface electrostatics. Initially, the average spectrum is fit to a Schottky barrier height of 0.71 eV, and the map is uniform with 98% of the spectra able to be fit. After 21 days, the average spectrum is fit to a Schottky barrier height of 0.62 eV, and the spatial map changes dramatically with only 27% of the spectra able to be fit. Transmission electron microscopy shows the formation of an ultra-thin tungsten silicide at themore » interface, which increases in thickness over the 21 days. This increase is attributed to an increase in electron scattering and the changes are observed in the BEEM measurements. Interestingly, little to no change is observed in the I-V measurements throughout the 21 day period.« less

Changing Families in a Changing Military System.

ERIC Educational Resources Information Center

Hunter, Edna J., Ed.

Recently, the military system has begun to feel the impact of the military family. Whenever sudden dramatic changes or transitions occur, crises may result either for the individual or for the institution. At present both the military system and the military family are in a period of rapid transition. Perhaps one of the most important changes that…

Electrochemical sensing of sulphur dioxide: a comparison using dodecanethiol and citrate capped gold nanoclusters.

PubMed

Sathe, Bhaskar R; Risbud, Mandar S; Mulla, Imtiaz S; Pillai, Vijayamohanan K

2008-06-01

A comparison of cyclic voltammograms of dodecanethiol (DDT) capped Au nanoclusters (5.0 0.5 nm) and trisodium citrate (Cit) capped Au nanoclusters (approximately 10-15 nm) modified glassy carbon electrode shows a dramatic variation in the current when exposed to a small amount of sulphur dioxide. This is explained using the electrocatalytic properties of Au nanoclusters towards the oxidation of SO2, thus facilitating the fabrication of electrochemical sensors for the detection of SO2. The intrinsic redox changes observed for gold nanocluster-modified glassy carbon electrodes disappear on passing SO2, despite a dramatic current increase, which indeed scales up with the amount of dissolved SO2. Interestingly, a complete rejuvenation of the redox behavior of gold is also observed on subsequent removal of SO2 from the solution by passing pure nitrogen for 15 minutes. Further, these nanoclusters when characterized with X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) after SO2 passage reveal a variety of SO2 adsorption modes on gold surface. XP spectra also show a shift of 1.03 eV towards higher binding energy indicating a strong adsorption of SO2 gas, while FTIR gives conclusive evidence for the interaction of SO2 with gold nanoparticles.

Advanced manufacturing: Technology and international competitiveness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tesar, A.

1995-02-01

Dramatic changes in the competitiveness of German and Japanese manufacturing have been most evident since 1988. All three countries are now facing similar challenges, and these challenges are clearly observed in human capital issues. Our comparison of human capital issues in German, Japanese, and US manufacturing leads us to the following key judgments: Manufacturing workforces are undergoing significant changes due to advanced manufacturing technologies. As companies are forced to develop and apply these technologies, the constituency of the manufacturing workforce (especially educational requirements, contingent labor, job content, and continuing knowledge development) is being dramatically and irreversibly altered. The new workforcemore » requirements which result due to advanced manufacturing require a higher level of worker sophistication and responsibility.« less

Impacts of Land use change on air quality and climate of Hangzhou City, South Eastern parts of China

NASA Astrophysics Data System (ADS)

Singh, R. P.; Zheng, S.

2016-12-01

Land use and land cover change (LUCC) influence the weather and climate conditions at local, regional and global scales. It has dramatically altered the Earth's landscape, chemical fluxes and influences the Earth's climate. The rapid land use change is often related to urban sprawl, farmland displacement, and deforestation. In the last two decades, land use land cover has rapidly changed in China especially along the eastern coastal region. Earlier studies have shown frequent (160 days in a year) occurrence of haze, fog and smog during 2003-2010 in and around Hangzhou city which lies in the south east coast region of China. An analysis of ground observed air quality and trace gases from 11 stations in Hangzhou city and satellite retrieved atmospheric parameters from 2011-2015 show increasing air quality and atmospheric pollution. The pollutants show very dynamic nature especially during winter season associated with the mixing with the influx of air mass from the surrounding regions. The frequent occurrences of fog, haze and smog over Hangzhou city is associated with the land use and land cover change of 16596 km2 areas, home of 9.02 million people. The spatial-temporal characteristics of land use change and air quality in response to rapid urbanization will be presented.

Welfare maximisation in public transport : an analysis of the development in 7 Norwegian cities : summary

DOT National Transportation Integrated Search

2001-01-01

Framework conditions for Norwegian public transport have changed substantially over : the past two decades. Operating subsidies in Norwegian conurbations have been cut : dramatically. Changes in the Transport Act, which allowed for competitive tender...

Changing pattern of the subcellular distribution of erythroblast macrophage protein (Emp) during macrophage differentiation.

PubMed

Soni, Shivani; Bala, Shashi; Kumar, Ajay; Hanspal, Manjit

2007-01-01

Erythroblast macrophage protein (Emp) mediates the attachment of erythroid cells to macrophages and is required for normal differentiation of both cell lineages. In erythroid cells, Emp is believed to be involved in nuclear extrusion, however, its role in macrophage differentiation is unknown. Information on the changes in the expression level and subcellular distribution of Emp in differentiating macrophages is essential for understanding the function of Emp. Macrophages of varying maturity were examined by immunofluorescence microscopy and biochemical methods. Our data show that Emp is expressed in all stages of maturation, but its localization pattern changes dramatically during maturation: in immature macrophages, a substantial fraction of Emp is associated with the nuclear matrix, whereas in more mature cells, Emp is expressed largely at cell surface. Pulse-chase experiments show that nascent Emp migrates intracellularly from the cytoplasm to the plasma membrane more efficiently in mature macrophages than in immature cells. Incubation of erythroid cells with macrophages in culture shows that erythroid cells attach to mature macrophages but not to immature macrophage precursors. Together, our data show that the temporal and spatial expression of Emp correlates with its role in erythroblastic island formation and suggest that Emp may be involved in multiple cellular functions.

*CHANGING PATTERN OF THE SUBCELLULAR DISTRIBUTION OF ERYTHROBLAST MACROPHAGE PROTEIN (EMP) DURING MACROPHAGE DIFFERENTIATION

PubMed Central

Soni, Shivani; Bala, Shashi; Kumar, Ajay; Hanspal, Manjit

2007-01-01

Erythroblast macrophage protein (Emp), mediates the attachment of erythroid cells to macrophages, and is required for normal differentiation of both cell lineages. In erythroid cells Emp is believed to be involved in nuclear extrusion however, its role in macrophage differentiation is unknown. Information on the changes in the expression level and subcellular distribution of Emp in differentiating macrophages is essential for understanding the function of Emp. Macrophages of varying maturity were examined by immunofluorescence microscopy and biochemical methods. Our data shows that Emp is expressed in all stages of maturation, but its localization pattern changes dramatically during maturation: in immature macrophages, a substantial fraction of Emp is associated with the nuclear matrix, whereas in more mature cells, Emp is expressed largely at cell surface. Pulse-chase experiments show that nascent Emp migrates intracellularly from the cytoplasm to the plasma membrane more efficiently in mature macrophages than in immature cells. Incubation of erythroid cells with macrophages in culture show that erythroid cells attach to mature macrophages but not to immature macrophage precursors. Together, our data shows that the temporal and spatial expression of Emp correlates with its role in erythroblastic island formation, and suggests that Emp may be involved in multiple cellular functions. PMID:17071116

Characterization of selected LDEF polymer matrix resin composite materials

NASA Technical Reports Server (NTRS)

Young, Philip R.; Slemp, Wayne S.; Witte, William G., Jr.; Shen, James Y.

1991-01-01

The characterization of selected graphite fiber reinforced epoxy (934 and 5208) and polysulfone (P1700) matrix resin composite materials which received 5 years and 10 months of exposure to the LEO environment on the Long Duration Exposure Facility is reported. Resin loss and a decrease in mechanical performance as well as dramatic visual effects were observed. However, chemical characterization including infrared, thermal, and selected solution property measurements showed that the molecular structure of the polymeric matrix had not changed significantly in response to this exposure. The potential effect of a silicon-containing molecular contamination of these specimens is addressed.

Super-Resolution Imaging of Molecular Emission Spectra and Single Molecule Spectral Fluctuations

PubMed Central

Mlodzianoski, Michael J.; Curthoys, Nikki M.; Gunewardene, Mudalige S.; Carter, Sean; Hess, Samuel T.

2016-01-01

Localization microscopy can image nanoscale cellular details. To address biological questions, the ability to distinguish multiple molecular species simultaneously is invaluable. Here, we present a new version of fluorescence photoactivation localization microscopy (FPALM) which detects the emission spectrum of each localized molecule, and can quantify changes in emission spectrum of individual molecules over time. This information can allow for a dramatic increase in the number of different species simultaneously imaged in a sample, and can create super-resolution maps showing how single molecule emission spectra vary with position and time in a sample. PMID:27002724

Quantifying changes in the rates of forest clearing in Indonesia from 1990 to 2005 using remotely sensed data sets

NASA Astrophysics Data System (ADS)

Hansen, Matthew C.; Stehman, Stephen V.; Potapov, Peter V.; Arunarwati, Belinda; Stolle, Fred; Pittman, Kyle

2009-07-01

Timely and accurate data on forest change within Indonesia is required to provide government, private and civil society interests with the information needed to improve forest management. The forest clearing rate in Indonesia is among the highest reported by the United Nations Food and Agriculture Organization (FAO), behind only Brazil in terms of forest area lost. While the rate of forest loss reported by FAO was constant from 1990 through 2005 (1.87 Mha yr-1), the political, economic, social and environmental drivers of forest clearing changed at the close of the last century. We employed a consistent methodology and data source to quantify forest clearing from 1990 to 2000 and from 2000 to 2005. Results show a dramatic reduction in clearing from a 1990s average of 1.78 Mha yr-1 to an average of 0.71 Mha yr-1 from 2000 to 2005. However, annual forest cover loss indicator maps reveal a near-monotonic increase in clearing from a low in 2000 to a high in 2005. Results illustrate a dramatic downturn in forest clearing at the turn of the century followed by a steady resurgence thereafter to levels estimated to exceed 1 Mha yr-1 by 2005. The lowlands of Sumatra and Kalimantan were the site of more than 70% of total forest clearing within Indonesia for both epochs; over 40% of the lowland forests of these island groups were cleared from 1990 to 2005. The method employed enables the derivation of internally consistent, national-scale changes in the rates of forest clearing, results that can inform carbon accounting programs such as the Reducing Emissions from Deforestation and Forest Degradation in Developing Countries (REDD) initiative.

Genetic divergence between freshwater and marine morphs of alewife (Alosa pseudoharengus): a 'next-generation' sequencing analysis.

PubMed

Czesny, Sergiusz; Epifanio, John; Michalak, Pawel

2012-01-01

Alewife Alosa pseudoharengus, a small clupeid fish native to Atlantic Ocean, has recently (∼150 years ago) invaded the North American Great Lakes and despite challenges of freshwater environment its populations exploded and disrupted local food web structures. This range expansion has been accompanied by dramatic changes at all levels of organization. Growth rates, size at maturation, or fecundity are only a few of the most distinct morphological and life history traits that contrast the two alewife morphs. A question arises to what extent these rapidly evolving differences between marine and freshwater varieties result from regulatory (including phenotypic plasticity) or structural mutations. To gain insights into expression changes and sequence divergence between marine and freshwater alewives, we sequenced transcriptomes of individuals from Lake Michigan and Atlantic Ocean. Population specific single nucleotide polymorphisms were rare but interestingly occurred in sequences of genes that also tended to show large differences in expression. Our results show that the striking phenotypic divergence between anadromous and lake alewives can be attributed to massive regulatory modifications rather than coding changes.

Genetic Divergence between Freshwater and Marine Morphs of Alewife (Alosa pseudoharengus): A ‘Next-Generation’ Sequencing Analysis

PubMed Central

Czesny, Sergiusz; Epifanio, John; Michalak, Pawel

2012-01-01

Alewife Alosa pseudoharengus, a small clupeid fish native to Atlantic Ocean, has recently (∼150 years ago) invaded the North American Great Lakes and despite challenges of freshwater environment its populations exploded and disrupted local food web structures. This range expansion has been accompanied by dramatic changes at all levels of organization. Growth rates, size at maturation, or fecundity are only a few of the most distinct morphological and life history traits that contrast the two alewife morphs. A question arises to what extent these rapidly evolving differences between marine and freshwater varieties result from regulatory (including phenotypic plasticity) or structural mutations. To gain insights into expression changes and sequence divergence between marine and freshwater alewives, we sequenced transcriptomes of individuals from Lake Michigan and Atlantic Ocean. Population specific single nucleotide polymorphisms were rare but interestingly occurred in sequences of genes that also tended to show large differences in expression. Our results show that the striking phenotypic divergence between anadromous and lake alewives can be attributed to massive regulatory modifications rather than coding changes. PMID:22438868

Targeting SMN to Cajal bodies and nuclear gems during neuritogenesis

PubMed Central

Navascues, Joaquin; Berciano, Maria T.; Tucker, Karen E.

2006-01-01

Neurite outgrowth is a central feature of neuronal differentiation. PC12 cells are a good model system for studying the peripheral nervous system and the outgrowth of neurites. In addition to the dramatic changes observed in the cytoplasm, neuronal differentiation is also accompanied by striking changes in nuclear morphology. The large and sustained increase in nuclear transcription during neuronal differentiation requires synthesis of a large number of factors involved in pre-mRNA processing. We show that the number and composition of the nuclear subdomains called Cajal bodies and gems changes during the course of N-ras-induced neuritogenesis in the PC12-derived cell line UR61. The Cajal bodies found in undifferentiated cells are largely devoid of the survival of motor neurons (SMN) protein product. As cells shift to a differentiated state, SMN is not only globally upregulated, but is progressively recruited to Cajal bodies. Additional SMN foci (also known as Gemini bodies, gems) can also be detected. Using dual-immunogold labeling electron microscopy and mouse embryonic fibroblasts lacking the coilin protein, we show that gems clearly represent a distinct category of nuclear body. PMID:15164213

Phytoplankton Biogeography and Community Stability in the Ocean

PubMed Central

Cermeño, Pedro; de Vargas, Colomban; Abrantes, Fátima; Falkowski, Paul G.

2010-01-01

Background Despite enormous environmental variability linked to glacial/interglacial climates of the Pleistocene, we have recently shown that marine diatom communities evolved slowly through gradual changes over the past 1.5 million years. Identifying the causes of this ecological stability is key for understanding the mechanisms that control the tempo and mode of community evolution. Methodology/Principal Findings If community assembly were controlled by local environmental selection rather than dispersal, environmental perturbations would change community composition, yet, this could revert once environmental conditions returned to previous-like states. We analyzed phytoplankton community composition across >104 km latitudinal transects in the Atlantic Ocean and show that local environmental selection of broadly dispersed species primarily controls community structure. Consistent with these results, three independent fossil records of marine diatoms over the past 250,000 years show cycles of community departure and recovery tightly synchronized with the temporal variations in Earth's climate. Conclusions/Significance Changes in habitat conditions dramatically alter community structure, yet, we conclude that the high dispersal of marine planktonic microbes erases the legacy of past environmental conditions, thereby decreasing the tempo of community evolution. PMID:20368810

Assessing climate change impacts on soil salinity development with proximal and satellite sensors

USDA-ARS?s Scientific Manuscript database

Changes in climate patterns have dramatically influenced some agricultural areas. Examples include the historic 5-year drought in California’s San Joaquin Valley (SJV) and the 20-year above average annual rainfall in the Red River Valley (RRV) of the Midwestern USA. Climate change may have impacted ...

Birth Cohort Changes in Chinese College Students' Loneliness and Social Support

ERIC Educational Resources Information Center

Xin, Sufei; Xin, Ziqiang

2016-01-01

With the dramatic recent changes in Chinese society, Chinese college students' average levels of loneliness and social support might also have changed across their birth cohorts. The present cross-temporal meta-analysis of 56 studies (N = 21,541) found that Chinese college students' scores on the UCLA Loneliness Scale (Version 3) increased…

Drama and Routine in the Public Schools.

ERIC Educational Resources Information Center

Pondy, Louis R.; Huff, Anne S.

A case study of curricular change compares two leading models of organizational change. One model stresses the uncertainty and disorder of major changes and views them as dramatic events. The other model sees major organizational shifts as the result of ordinary day-to-day processes and emphasizes their routine nature. For this study, the…

School Business Management: The International Dimension

ERIC Educational Resources Information Center

Southworth, Geoff; Summerson, Trevor

2011-01-01

Most people do not think of schools as centers of revolution. Rather, they consider schools to be stable organizations that have not changed dramatically in how they operate. Indeed, some argue that school operations have changed remarkably little in the past 100 years. However, a change "has" been taking place in England that is…

Adapting to and Coping with the Threat and Impacts of Climate Change

ERIC Educational Resources Information Center

Reser, Joseph P.; Swim, Janet K.

2011-01-01

This article addresses the nature and challenge of adaptation in the context of global climate change. The complexity of "climate change" as threat, environmental stressor, risk domain, and impacting process with dramatic environmental and human consequences requires a synthesis of perspectives and models from diverse areas of psychology to…

Theorizing Teacher Agency and Reform: How Institutionalized Instructional Practices Change and Persist

ERIC Educational Resources Information Center

Bridwell-Mitchell, E. N.

2015-01-01

One reason reform does not dramatically change public schools is because instructional practices are highly institutionalized. This article advances a theory for how teacher agency can both change and maintain institutionalized instructional practices in schools. Based on findings from one U.S. urban public school undergoing state-mandated reform,…

Historic vegetation changes in Lincoln County, New Mexico: The Albuquerque Banquet Presentation

Treesearch

E. Hollis Fuchs

2008-01-01

(Please note, this is an abstract only) Repeat photography will demonstrate that since European settlement commenced, the native vegetation of Lincoln County, New Mexico has dramatically changed. Numerous historic photographs have been re-taken, demonstrating how landscapes and ecosystems have changed, not just between early European settlement until the present, but...

Adapting Wood Technology to Teach Design and Engineering

ERIC Educational Resources Information Center

Rummel, Robert A.

2012-01-01

Technology education has changed dramatically over the last few years. The transition of industrial arts to technology education and more recently the pursuit of design and engineering has resulted in technology education teachers often needing to change their curriculum and course activities to meet the demands of a rapidly changing profession.…

Student Diversity Requires Different Approaches to College Teaching, Even in Math and Science.

ERIC Educational Resources Information Center

Nelson, Craig E.

1996-01-01

Asserts that traditional teaching methods are unintentionally biased towards the elite and against many non-traditional students. Outlines several easily accessible changes in teaching methods that have fostered dramatic changes in student performance with no change in standards. These approaches have proven effective even in the fields of…

Children's Mental Health: The Changing Interface between Primary and Specialty Care. Reprint.

ERIC Educational Resources Information Center

Steinberg, A. G.; Gadomski, A.; Wilson, M. D.

The landscape for children's mental health services has changed dramatically due to the confluence of several factors. The emergence of managed care has influenced access to as well as the scope of primary care practice. Evidence-based medicine is steadily emerging and driving practice guideline development. In the rapidly changing and…

"E Pluribus"... Separation: Deepening Double Segregation for More Students

ERIC Educational Resources Information Center

Orfield, Gary; Kucsera, John; Siegel-Hawley, Genevieve

2012-01-01

This report shows segregation has increased dramatically across the country for Latino students, who are attending more intensely segregated and impoverished schools than they have for generations. The segregation increases have been the most dramatic in the West. The typical Latino student in the region attends a school where less than a quarter…

Approaches to predicting potential impacts of climate change on forest disease: An example with Armillaria root disease

Treesearch

Ned B. Klopfenstein; Mee-Sook Kim; John W. Hanna; Bryce A. Richardson; John E. Lundquist

2011-01-01

Climate change will likely have dramatic impacts on forest health because many forest trees could become maladapted to climate. Furthermore, climate change will have additional impacts on forest health through changes in the distribution and severity of forest disease. Methods are needed to predict the influence of climate change on forest disease so that appropriate...

Near-field thermal rectification devices using phase change periodic nanostructure.

PubMed

Ghanekar, Alok; Tian, Yanpei; Ricci, Matthew; Zhang, Sinong; Gregory, Otto; Zheng, Yi

2018-01-22

We theoretically analyze two near-field thermal rectification devices: a radiative thermal diode and a thermal transistor that utilize a phase change material to achieve dynamic control over heat flow by exploiting metal-insulator transition of VO 2 near 341 K. The thermal analogue of electronic diode allows high heat flow in one direction while it restricts the heat flow when the polarity of temperature gradient is reversed. We show that with the introduction of 1-D rectangular grating, thermal rectification is dramatically enhanced in the near-field due to reduced tunneling of surface waves across the interfaces for negative polarity. The radiative thermal transistor also works around phase transition temperature of VO 2 and controls heat flow. We demonstrate a transistor-like behavior wherein heat flow across the source and the drain can be greatly varied by making a small change in gate temperature.

Man induced change in community control in the north-western Black Sea: The top-down bottom-up balance.

PubMed

Bănaru, Daniela; Harmelin-Vivien, Mireille; Boudouresque, Charles F

2010-05-01

The present study shows how marine commercial fish food webs dramatically changed in the north-western Black Sea on both pelagic and benthic environments. Fisheries landings, diversity and equitability strongly decreased between 1965-1970 and 2001-2005. Fishes adapted their feeding behaviour to the increasingly low species diversity of the Black Sea communities. Their food web became poor and simplified following the loss of many top predator species and their trophic links. Linkage density, connectivity and Lyapunov stability proxy strongly decreased. The north-western Black Sea system switched from a complex top-down and bottom-up functioning pattern to a dominantly bottom-up functioning pattern. This study contributes to a better understanding of these transformations within the Danube-Black Sea system in the last decades. An attempt is made to relate these changes with river inputs, fisheries and coastal pollution. Copyright 2009 Elsevier Ltd. All rights reserved.

Popular perceptions of emerging influences on mortality and longevity in Bangladesh and West Bengal.

PubMed

Amin, Sajeda; Basu, Alaka Malwade

2004-01-01

Relatively little is known about how environmental and pathological threats to human survival and longevity are perceived by the public. In this study in rural Bangladesh and West Bengal, India, which used individual interviews and focus-group discussions to investigate the changing costs of and motivations for reproduction, respondents were questioned about their perceptions of changes in mortality. The findings show that, while child mortality levels are perceived to have fallen dramatically in recent times, the health and survival prospects of the middle aged and the elderly are seen to have been better in the past. The perceived decline in adult health is attributed to environmental deterioration and lifestyle changes accompanying modernization. This paper explores people's reasons for this unexpected worldview. References to pesticides and chemical fertilizers as causes of death abound in their explanations and are seen to be associated with unhealthy agricultural practices and impiety.

A 3400 year paleolimnological record of prehispanic human–environment interactions in the Holmul region of the southern Maya lowlands

USGS Publications Warehouse

Wahl, David B.; Estrada-Belli, Francisco; Anderson, Lysanna

2015-01-01

The timing, magnitude and drivers of late Holocene environmental change in the Holmul region of the southern Maya lowlands are examined by combining paleoenvironmental and archeological data. Environmental proxy analyses on a ~ 3350 cal yr lacustrine sediment record include pollen, charcoal, loss on ignition, magnetic suscep- tibility, and elemental geochemistry. Archeological evidence is derived from extensive settlement surveys conducted near the study site. Results indicate nearby settlement and agricultural activity taking place in an environment characterized by open forest from around 3350 to 950 cal yr BP. The fire history shows a dramatic increase in burning during the Classic period, possibly reflecting changing agricultural strategies. A distinct band of carbonate deposited from 1270 to 1040 cal yr BP suggests decreased hydrologic input associated with drier conditions. Abrupt changes in proxy data around 940 cal yr BP indicate a cessation of human disturbance and local abandonment of the area.

Nucleon-nucleon scattering in a strong external magnetic field and the neutrino emissivity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bavarsad, E.; Mohammadi, R.; Haghighat, M.

The nucleon-nucleon scattering in a large magnetic background is considered to find its potential to change the neutrino emissivity of the neutron stars. For this purpose, we consider the one-pion-exchange approximation to find the nucleon-nucleon (NN) cross section in a background field as large as 10{sup 15}-10{sup 18} G. We show that the NN cross section in neutron stars with temperatures in the range 0.1-5 MeV can be changed up to the 1 order of magnitude with respect to the one in the absence of the magnetic field. In the limit of the soft neutrino emission, the neutrino emissivity canmore » be written in terms of the NN-scattering amplitude; therefore, the large magnetic fields can dramatically change the neutrino emissivity of the neutron stars as well.« less

Sensitivity of a high-elevation Rocky Mountain watershed to altered climate and CO2

USGS Publications Warehouse

Baron, Jill S.; Hartman, Melannie D.; Band, L.E.; Lammers, R.B.

2000-01-01

We explored the hydrologic and ecological responses of a headwater mountain catchment, Loch Vale watershed, to climate change and doubling of atmospheric CO2 scenarios using the Regional Hydro-Ecological Simulation System (RHESSys). A slight (2°C) cooling, comparable to conditions observed over the past 40 years, led to greater snowpack and slightly less runoff, evaporation, transpiration, and plant productivity. An increase of 2°C yielded the opposite response, but model output for an increase of 4°C showed dramatic changes in timing of hydrologic responses. The snowpack was reduced by 50%, and runoff and soil water increased and occurred 4–5 weeks earlier with 4°C warming. Alpine tundra photosynthetic rates responded more to warmer and wetter conditions than subalpine forest, but subalpine forest showed a greater response to doubling of atmospheric CO2 than tundra. Even though water use efficiency increased with the double CO2 scenario, this had little effect on basin-wide runoff because the catchment is largely unvegetated. Changes in winter and spring climate conditions were more important to hydrologic and vegetation dynamics than changes that occurred during summer.

Temperature-induced mismatches between consumption and metabolism reduce consumer fitness.

PubMed

Lemoine, Nathan P; Burkepile, Deron E

2012-11-01

As physiological processes of ectotherms are coupled to environmental temperature, climate change will likely alter their fundamental biological rates, including metabolism, consumption, growth, and reproduction. Here we combine the metabolic theory of ecology (MTE) with metabolism and consumption measurements of a model organism, the urchin Lytechinus variegatus, to test how climate change will affect consumer fitness. Unexpectedly, we found that metabolism and consumption exhibit different scaling relationships with temperature and are mismatched at high temperatures. This led to a dramatic reduction in ingestion efficiency and potentially in consumer fitness. Using metaanalysis, we showed that such temperature-driven mismatches between consumption and metabolism are common across taxa and frequently lead to reduced consumer fitness. Our empirical and synthetic analyses identify a mechanism by which climate change reduces the fitness of ectotherm consumers that may be applied to a broad array of taxonomic groups. Moreover, we showed that the assumptions of MTE do not hold at temperatures near the upper range of species' thermal tolerances for a wide array of taxa. Models using MTE to predict the effects of climate change on consumer-resource dynamics may therefore be underestimating the consequences of rising temperatures on population and community dynamics.

Effect of denervation and reinnervation on oxidation of 6-(C-14) glucose by rat skeletal muscle homogenates

NASA Technical Reports Server (NTRS)

Dubois, D. C.; Max, S. R.

1983-01-01

The effects of denervation and reinnervation of the rat extensor digitorum longus muscle on the oxidation of 6-(C-14) glucose to (C-14)O2 is investigated. Results show that the rate of (C-14)O2 production decreased dramatically following denervation and the decrease became significant 20 days after nerve section. The changes which occurred prior to day 20 apparently reflected the decline of muscle mass. The decreased (C-14)O2 production was found to be due to reduced capacity of the enzymatic system, while there was no change in the apparent affinity for glucose. Results of mixing experiments showed that the loss of oxidative capacity following denervation is not caused by the production of soluble inhibitors by degenerating muscle. Measurements of the (C-14)O2 revealed that oxidative metabolism recovered during reinnervation. The specific activity in reinnervated muscles displayed an 'overshoot' of approximately 50 percent, which returned to control levels by day 60. The time-course of the denervation-mediated change indicates that altered oxidative capacity is secondary to events that initiate dennervation changes in muscle, although diminished oxidative capacity may be of considerable metabolic significance in denervated muscle.

Computing Cosmic Cataclysms

NASA Technical Reports Server (NTRS)

Centrella, Joan M.

2010-01-01

The final merger of two black holes releases a tremendous amount of energy, more than the combined light from all the stars in the visible universe. This energy is emitted in the form of gravitational waves, and observing these sources with gravitational wave detectors requires that we know the pattern or fingerprint of the radiation emitted. Since black hole mergers take place in regions of extreme gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these wave patterns. For more than 30 years, scientists have tried to compute these wave patterns. However, their computer codes have been plagued by problems that caused them to crash. This situation has changed dramatically in the past few years, with a series of amazing breakthroughs. This talk will take you on this quest for these gravitational wave patterns, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed.

Frederick Douglass Changed My Mind about the Constitution

ERIC Educational Resources Information Center

Oakes, James

2008-01-01

Frederick Douglass dramatically and publicly changed his own mind about the Constitution. Like Frederick Douglass, the author had originally viewed the Constitution as pro-slavery. Yet a close look at Douglass's writings revealed a Constitution that empowered the federal government to abolish slavery.

Evolution and devolution : a national perspective on the changing role of metropolitan planning organizations in areawide intermodal planning.

DOT National Transportation Integrated Search

1997-01-01

The Intermodal Surface Transportation Efficiency Act of 1991 (ISTEA) dramatically changed the metropolitan planning process by presenting new opportunities and responsibilities to the institutions in charge of metropolitan planning. The legislation f...

Racial Diversity in the Suburbs: How Race-Neutral Responses to Demographic Change Perpetuate Inequity in Suburban School Districts

ERIC Educational Resources Information Center

Diem, Sarah; Welton, Anjalé D.; Frankenberg, Erica; Jellison Holme, Jennifer

2016-01-01

Suburbs across the US are experiencing dramatic demographic shifts, yet there is little research available on how suburban school districts are dealing with these changes. In this article, we examine the discourses surrounding race and demographic change in three suburban school districts that have been undergoing rapid demographic changes and…

Ecosystem vulnerability assessment and synthesis: a report from the Climate Change Response Framework Project in northern Wisconsin

Treesearch

Chris Swanston; Maria Janowiak; Louis Iverson; Linda Parker; David Mladenoff; Leslie Brandt; Patricia Butler; Matt St. Pierre; Anantha Prasad; Stephen Matthews; Matthew Peters; Dale Higgins; Avery Dorland

2011-01-01

The forests of northern Wisconsin will likely experience dramatic changes over the next 100 years as a result of climate change. This assessment evaluates key forest ecosystem vulnerabilities to climate change across northern Wisconsin under a range of future climate scenarios. Warmer temperatures and shifting precipitation patterns are expected to influence ecosystem...

Genes involved in leukotriene synthesis pathway are dynamically regulated during lung development in Rhesus monkeys.

PubMed

Xia, Wanmin; Xie, Liang; Cao, Bangrong; Cheng, Shujun; Wan, Huajing; Liu, Hanmin

2017-07-01

Leukotrienes play critical roles in many inflammatory lung diseases and several antagonists of their receptors have been used in the clinical settings. However, the physiological functions of leukotrienes in lung development are still unclear. The expression levels of 34 genes involved in leukotriene synthesis and function pathway in the lungs of Rhesus monkey during different developmental time points were determined on a MiSeq platform and analyzed by the reads per kilobase of transcript per million mapped reads (RPKM) method. The results showed that the expression levels of PLA2G1B, PLA2G10, PLA2G2D, ALOX5, and ALOX5AP increased dramatically in the lung of Rhesus monkey, reflecting the changes in the pulmonary environment after delivery. Additionally, the different expression patterns between molecules related to LTB4 and LTC4 synthesis suggested distinct roles of LTB4 and LTC4 in lung development. Finally, the constant expression of CysLT1 during the development process provided new information to the pharmaceutical basis of the use of leukotriene receptor antagonists in the clinical setting. The expression levels of several key genes involved in leukotriene synthesis changed dramatically during lung development in Rhesus monkeys, suggesting the potential roles of leukotrienes in lung development in this animal model. Copyright © 2017 Elsevier Ltd. All rights reserved.

A ditopic colorimetric sensor for fluoride ion based on thiourea mercury complex.

PubMed

Sun, Mei-Zhen; Wu, Fang-Ying; Wu, Yu-Mei; Liu, Wen-Ming

2008-12-01

A novel ditopic chromogenic receptor, N-5-(8-hydroxy)quinoline-N'-4'-nitro-phenyl thiourea (1), was synthesized. The metal complex 1-Hg(2+) showed sensitive and highly selective responses to F(-) over other anions such as CH(3)CO(2)(-), H(2)PO(4)(-), HSO(4)(-) and Cl(-). 1-Hg(2+)-F(-) complex formed, which promoted the intramolecular charge transfer and led to a dramatic spectral change. The color of 1-Hg(2+) solution changed from colorless to red upon addition of F(-). Thus, a colorimetric assay of F(-) was developed in acetonitrile by naked-eye detection. F(-) behaved linearly in the 8.0 x 10(-6) to 2.0 x 10(-5) mol L(-1) concentration range with LOD as 1.4 x 10(-6) mol L(-1).

Energy driven self-organization in nanoscale metallic liquid films.

PubMed

Krishna, H; Shirato, N; Favazza, C; Kalyanaraman, R

2009-10-01

Nanometre thick metallic liquid films on inert substrates can spontaneously dewet and self-organize into complex nanomorphologies and nanostructures with well-defined length scales. Nanosecond pulses of an ultraviolet laser can capture the dewetting evolution and ensuing nanomorphologies, as well as introduce dramatic changes to dewetting length scales due to the nanoscopic nature of film heating. Here, we show theoretically that the self-organization principle, based on equating the rate of transfer of thermodynamic free energy to rate of loss in liquid flow, accurately describes the spontaneous dewetting. Experimental measurements of laser dewetting of Ag and Co liquid films on SiO(2) substrates confirm this principle. This energy transfer approach could be useful for analyzing the behavior of nanomaterials and chemical processes in which spontaneous changes are important.

A pH-responsive wormlike micellar system of a noncovalent interaction-based surfactant with a tunable molecular structure.

PubMed

Kang, Wanli; Wang, Pengxiang; Fan, Haiming; Yang, Hongbin; Dai, Caili; Yin, Xia; Zhao, Yilu; Guo, Shujun

2017-02-08

Responsive wormlike micelles are very useful in a number of applications, whereas it is still challenging to create dramatic viscosity changes in wormlike micellar systems. Here we developed a pH-responsive wormlike micellar system based on a noncovalent constructed surfactant, which is formed by the complexation of N-erucamidopropyl-N,N-dimethylamine (UC 22 AMPM) and citric acid at the molar ratio of 3 : 1 (EACA). The phase behavior, aggregate microstructure and viscoelasticity of EACA solutions were investigated by macroscopic appearance observation, rheological and cryo-TEM measurements. It was found that the phase behavior of EACA solutions undergoes transition from transparent viscoelastic fluids to opalescent solutions and then phase separation with white floaters upon increasing the pH. Upon increasing the pH from 2.03 to 6.17, the viscosity of wormlike micelles in the transparent solutions continuously increased and reached ∼683 000 mPa s at pH 6.17. As the pH was adjusted to 7.31, the opalescent solution shows a water-like flowing behaviour and the η 0 rapidly declines to ∼1 mPa s. Thus, dramatic viscosity changes of about 6 magnitudes can be triggered by varying the pH values without any deterioration of the EACA system. This drastic variation in rheological behavior is attributed to the pH dependent interaction between UC 22 AMPM and citric acid. Furthermore, the dependence on concentration and temperature of the rheological behavior of EACA solutions was also studied to assist in obtaining the desired pH-responsive viscosity changes.

Ligand-Mediated Activation of an Engineered Gs G Protein-Coupled Receptor in Osteoblasts Increases Trabecular Bone Formation

PubMed Central

Hsiao, Edward C.; Millard, Susan M.; Louie, Alyssa; Huang, Yong; Conklin, Bruce R.; Nissenson, Robert A.

2010-01-01

Age-dependent changes in skeletal growth play important roles in regulating skeletal expansion and in the course of many diseases affecting bone. How G protein-coupled receptor (GPCR) signaling affects these changes is poorly understood. Previously, we described a mouse model expressing Rs1, an engineered receptor with constitutive Gs activity. Rs1 expression in osteoblasts from gestation induced a dramatic age-dependent increase in trabecular bone with features resembling fibrous dysplasia; however, these changes were greatly minimized if Rs1 expression was delayed until after puberty. To further investigate whether ligand-induced activation of the Gs-GPCR pathway affects bone formation in adult mice, we activated Rs1 in adult mice with the synthetic ligand RS67333 delivered continuously via an osmotic pump or intermittently by daily injections. We found that osteoblasts from adult animals can be stimulated to form large amounts of bone, indicating that adult mice are sensitive to the dramatic bone- forming actions of Gs signaling in osteoblasts. In addition, our results show that intermittent and continuous activation of Rs1 led to structurally similar but quantitatively different degrees of trabecular bone formation. These results indicate that activation of a Gs-coupled receptor in osteoblasts of adult animals by either intermittent or continuous ligand administration can increase trabecular bone formation. In addition, osteoblasts located at the bone epiphyses may be more responsive to Gs signaling than osteoblasts at the bone diaphysis. This model provides a powerful tool for investigating the effects of ligand-activated Gs-GPCR signaling on dynamic bone growth and remodeling. PMID:20150184

Dynamics of Liquids in Edges and Corners (DYLCO): IML-2 Experiment for the BDPU

NASA Technical Reports Server (NTRS)

Langbein, D.; Weislogel, M.

1998-01-01

Knowledge of the behavior of fluids possessing free surfaces is important to many fluid systems, particularly in space, where the normally subtle effects of surface wettability play a more dramatic and often surprising role. DYLCO for the IML-2 mission was proposed as a simple experiment to probe the particular behavior of capillary surfaces in containers of irregular cross section. Temperature control was utilized to vary the fluid-solid contact angle, a questionable thermodynamic parameter of the system, small changes in which can dramatically influence the configuration, stability, and flow of a capillary surface. Container shapes, test fluid, and temperature ranges were selected for observing both local changes in interface curvature as well as a global change in fluid orientation due to a critical wetting phenomenon. The experiment hardware performed beyond what was expected and fluid interfaces could be readily digitized post flight to show the dependence of the interface curvature on temperature. For each of the containers tested surfaces were observed which did not satisfy the classic equations for the prediction of interface shape with constant contact angle boundary condition. This is explained by the presence of contact angle hysteresis arising from expansion and contraction of the liquid during the heating and cooling steps of the test procedure. More importantly, surfaces exceeding the critical surface curvature required for critical wetting were measured, yet no wetting was observed. These findings are indeed curious and pose key questions concerning the role of hysteresis for this critical wetting phenomena. The stability of such surfaces was determined numerically and it is shown that stability is enhance (reduced) when a surface is in its 'advancing' ('receding') state, The analysis shows complete instability as the critical wetting condition is reached. The case of ideal dynamic wetting is addressed analytically in detail with results of significant flow characteristics presented in closed form. The solutions indicate a square root of T dependence of the capillary 'rise' rate which is corroborated by drop tower tests. The analysis clearly shows that infinite time is necessary for surfaces to reorient at the critical wetting transition.

Crude oil price dynamics: A study on effects of market expectation and strategic supply on price movements

NASA Astrophysics Data System (ADS)

Jin, Xin

Recent years have seen dramatic fluctuations in crude oil prices. This dissertation attempts to better understand price behavior. The first chapter studies the behavior of crude oil spot and futures prices. Oil prices, particularly spot and short-term futures prices, appear to have switched from I(0) to I(1) in early 2000s. To better understand this apparent change in persistence, a factor model of oil prices is proposed, where the prices are decomposed into long-term and short-term components. The change in the persistence behavior can be explained by changes in the relative volatility of the underlying components. Fitting the model to weekly data on WTI prices, the volatility of the persistent shocks increased substantially relative to other shocks. In addition, the risk premiums in futures prices have changed their signs and become more volatile. The estimated net marginal convenience yield using the model also shows changes in its behavior. These observations suggest that a dramatic fundamental change occurred in the period from 2002 to 2004 in the dynamics of the crude oil market. The second chapter explores the short-run price-inventory dynamics in the presence of different shocks. Classical competitive storage model states that inventory decision considers both current and future market condition, and thus interacts with spot and expected future spot prices. We study competitive storage holding in an equilibrium framework, focusing on the dynamic response of price and inventory to different shocks. We show that news shock generates response profile different from traditional contemporaneous shocks in price and inventory. The model is applied to world crude oil market, where the market expectation is estimated to experience a sharp change in early 2000s, together with a persisting constrained supply relative to demand. The expectation change has limited effect on crude oil spot price though. The world oil market structure has been studied extensively but no consensus has been reached on OPEC strategic behavior. In the third chapter, we are interested in the effects of supply-side market power on oil price dynamics in face of different demand shocks, and model the oil market as composed of a strategic dominant firm and several competitive fringe producers. In each period, the dominant firm makes decision while taking fringe's response into consideration. We consider two alternative pricing strategies for the dominant firm. Our results show that this dynamic strategic model improves the potential of dominant firm-competitive fringe model in fitting and explaining real world data. A regime switch after a permanent demand increase generates a time path for price that looks like the price movements in the recent years.

Global Albedo Variations on Mars from Recent MRO/MARCI and Other Space-Based Observations

NASA Astrophysics Data System (ADS)

Bell, J. F., III; Wellington, D. F.

2017-12-01

Dramatic changes in Mars surface albedo have been quantified by telescopic, orbital, and surface-based observations over the last 40 years. These changes provide important inputs for global and mesoscale climate models, enabling characterization of seasonal and secular variations in the distribution of mobile surface materials (dust, sand) in the planet's current climate regime. Much of the modern record of dust storms and albedo changes comes from synoptic-scale global imaging from the Viking Orbiter, Mars Global Surveyor (MGS), Hubble Space Telescope (HST), and Mars Reconnaissance Orbiter (MRO) missions, as well as local-scale observations from long-lived surface platforms like the Spirit and Opportunity rovers. Here we focus on the substantial time history of global-scale images acquired from the MRO Mars Color Imager (MARCI). MARCI is a wide-angle multispectral imager that acquires daily coverage of most of the surface at up to 1 km/pixel. MARCI has been in orbit since 2006, providing six Mars years of continuous surface and atmospheric observations, and building on the nearly five previous Mars years of global-scale imaging from the MGS Mars Orbiter Camera Wide Angle (MOC/WA) imager, which operated from 1997 to 2006. While many of the most significant MARCI-observed changes in the surface albedo are the result of large dust storms, other regions experience seasonal darkening events that repeat with different degrees of annual regularity. Some of these are associated with local dust storms, while for others, frequent surface changes take place with no associated evidence for dust storms, suggesting action by seasonally-variable winds and/or small-scale storms/dust devils too small to resolve. Discrete areas of dramatic surface changes across widely separated regions of Tharsis and in portions of Solis Lacus and Syrtis Major are among the regions where surface changes have been observed without a direct association to specific detectable dust storm events. Deposition following the annual southern summer dusty season plays a significant role in maintaining the cyclic nature of these changes. These and other historical observations also show that major regional or global-scale dust storms produce unique changes that may require several Mars years to reverse.

Flavor and chiral stability of lemon-flavored hard tea during storage.

PubMed

He, Fei; Qian, YanPing L; Qian, Michael C

2018-01-15

Flavor stability of hard tea beverage was investigated over eight weeks of storage. The volatile compounds were analyzed using solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) and two-dimensional GC-MS. Quantitative analysis showed that the concentrations of linalool, citronellol, geranial, neral, geraniol, and nerol decreased dramatically during storage, whereas α-terpineol showed an increasing trend during storage. Heart-cut two-dimensional GC-MS (2D-GC-MS) chirality analysis showed that (R)-(+)-limonene, (R)-(-)-linalool, (S)-(-)-α-terpineol and (S)-(-)-4-terpineol dominated in the fresh hard tea samples, however, the configuration changed during storage for the terpene alcohols. The storage conditions did not change the configuration of limonene. A conversion of (R)-(-)-linalool to (S)-(+) form was observed during storage. Both (S)-α-terpineol and (S)-4-terpineol dominated at beginning of the storage, but (R)-(+)-α-terpineol became dominated after storage, suggested in addition to isomerization from (S)-α-terpineol, other precursors could also generate α-terpineol with (R)-isomer preference. Copyright © 2017 Elsevier Ltd. All rights reserved.

Characterization of Thyroid Hormone Transporter Protein Expression during Tissue-specific Metamorphic Events in Xenopus tropicalis

EPA Science Inventory

Thyroid hormone (TH) induces the dramatic morphological and physiological changes that together comprise amphibian metamorphosis. TH-responsive tissues vary widely with developmental timing of TH-induced changes. How larval tadpole tissues are able to employ distinct metamorphi...

Drought stress suppresses phytoalexin production against Fusarium verticilliodes

USDA-ARS?s Scientific Manuscript database

Global climate change involves rising temperatures and potentially decreased rainfall or changes in rainfall patterns, which could dramatically decrease the yield of food crops. Drought alone can impair plant growth and development, but in nature plants are continuously exposed to both abiotic and b...

Guidelines for Psychological Practice with Girls and Women

ERIC Educational Resources Information Center

American Psychologist, 2007

2007-01-01

During recent decades, women and girls of diverse ethnicities, social classes, sexual orientations, and life experiences have encountered dramatic and complex changes in education, health, work, reproductive and caregiving roles, and personal relationships. Although many of these changes have resulted in increased equality, opportunity, and…

DISTRIBUTIONAL CHANGES AND POPULATION STATUS FOR AMPHIBIANS IN THE EASTERN MOJAVE DESERT

EPA Science Inventory

A number of amphibian species historically inhabited sparsely distributed wetlands in the Mojave Desert of western North America, habitats that have been dramatically altered or eliminated as a result of human activities. The population status and distributional changes for amphi...

Science Update: Inorganic Chemistry.

ERIC Educational Resources Information Center

Rawls, Rebecca

1981-01-01

Describes areas of inorganic chemistry which have changed dramatically in the past year or two, including photochemistry, electrochemistry, organometallic complexes, inorganic reaction theory, and solid state chemistry. (DS)

Update on Sporadic Colorectal Cancer Genetics.

PubMed

Hardiman, Karin M

2018-05-01

Our understanding of the genetics of colorectal cancer has changed dramatically over recent years. Colorectal cancer can be classified in multiple different ways. Along with the advent of whole-exome sequencing, we have gained an understanding of the scale of the genetic changes found in sporadic colorectal cancer. We now know that there are multiple pathways that are commonly involved in the evolution of colorectal cancer including Wnt/β-catenin, RAS, EGFR, and PIK3 kinase. Another recent leap in our understanding of colorectal cancer genetics is the recognition that many, if not all tumors, are actually genetically heterogeneous within individual tumors and also between tumors. Recent research has revealed the prognostic and possibly therapeutic implications of various specific mutations, including specific mutations in BRAF and KRAS . There is increasing interest in the use of mutation testing for screening and surveillance through stool and circulating DNA testing. Recent advances in translational research in colorectal cancer genetics are dramatically changing our understanding of colorectal cancer and will likely change therapy and surveillance in the near future.

Persistence length changes dramatically as RNA folds.

PubMed

Caliskan, G; Hyeon, C; Perez-Salas, U; Briber, R M; Woodson, S A; Thirumalai, D

2005-12-31

We determine the persistence length l(p) for a bacterial group I ribozyme as a function of concentration of monovalent and divalent cations by fitting the distance distribution functions P(r) obtained from small angle x-ray scattering intensity data to the asymptotic form of the calculated P(WLC)(r) for a wormlike chain. The l(p) values change dramatically over a narrow range of Mg(2+) concentration from approximately 21 Angstroms in the unfolded state (U) to approximately 10 Angstroms in the compact (I(C)) and native states. Variations in l(p) with increasing Na(+) concentration are more gradual. In accord with the predictions of polyelectrolyte theory we find l(p) alpha 1/kappa(2) where kappa is the inverse Debye-screening length.

Technical tips: Electrode application and preventing skin breakdown techniques.

PubMed

Berlin, Fira; Carlile, Jennifer A; de Burgo, Maria I; Rochon, Adrienne; Wagner, Esperanza E; Sellers, Martha C; Worrell, Amanda R; Andal, E Lauren C; Woods, Latina R

2011-09-01

The recording electrodes including their precise location, their ability to record during movements that can be intense during a convulsive seizure, and their capability to record for several days without causing skin breakdown are an integral part of long-term EEG recording. Many of the facets of EEG technology have changed dramatically with the introduction of digital EEG. But the electrode and the electrode/skin interface have not had many dramatic changes. The technologist still looks for ways to ensure correct electrode placement, good recording capabilities, and a patient with healthy skin when the electrodes are removed. This Technical Tips features ideas and experiences from several technologists. These technologists express suggestions and opinions which are accepted in Technical Tips.

Giant magneto-optical Raman effect in a layered transition metal compound

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ji, Jianting; Zhang, Anmin; Fan, Jiahe

2016-02-16

Here, we report a dramatic change in the intensity of a Raman mode with applied magnetic field, displaying a gigantic magneto-optical effect. Using the nonmagnetic layered material MoS 2 as a prototype system, we demonstrate that the application of a magnetic field perpendicular to the layers produces a dramatic change in intensity for the out-of-plane vibrations of S atoms, but no change for the in-plane breathing mode. The distinct intensity variation between these two modes results from the effect of field-induced broken symmetry on Raman scattering cross-section. A quantitative analysis on the field-dependent integrated Raman intensity provides a unique methodmore » to precisely determine optical mobility. Our analysis is symmetry-based and material-independent, and thus the observations should be general and inspire a new branch of inelastic light scattering and magneto-optical applications.« less

Stability and Longevity in the Publication Careers of U.S. Doctorate Recipients

PubMed Central

Waaijer, Cathelijn J. F.; Macaluso, Benoît; Sugimoto, Cassidy R.; Larivière, Vincent

2016-01-01

Since the 1950s, the number of doctorate recipients has risen dramatically in the United States. In this paper, we investigate whether the longevity of doctorate recipients’ publication careers has changed. This is achieved by matching 1951–2010 doctorate recipients with rare names in astrophysics, chemistry, economics, genetics and psychology in the dissertation database ProQuest to their publications in the publication database Web of Science. Our study shows that pre-PhD publication careers have changed: the median year of first publication has shifted from after the PhD to several years before PhD in most of the studied fields. In contrast, post-PhD publication career spans have not changed much in most fields. The share of doctorate recipients who have published for more than twenty years has remained stable over time; the shares of doctorate recipients publishing for shorter periods also remained almost unchanged. Thus, though there have been changes in pre-PhD publication careers, post-PhD career spans remained quite stable. PMID:27128633

Calcium-Responsive Liposomes via a Synthetic Lipid Switch.

PubMed

Lou, Jinchao; Carr, Adam J; Watson, Alexa J; Mattern-Schain, Samuel I; Best, Michael D

2018-03-07

Liposomal drug delivery would benefit from enhanced control over content release. Here, we report a novel avenue for triggering release driven by chemical composition using liposomes sensitized to calcium-a target chosen due to its key roles in biology and disease. To demonstrate this principle, we synthesized calcium-responsive lipid switch 1, designed to undergo conformational changes upon calcium binding. The conformational change perturbs membrane integrity, thereby promoting cargo release. This was shown through fluorescence-based release assays via dose-dependent response depending on the percentage of 1 in liposomes, with minimal background leakage in controls. DLS experiments indicated dramatic changes in particle size upon treatment of liposomes containing 1 with calcium. In a comparison of ten naturally occurring metal cations, calcium provided the greatest release. Finally, STEM images showed significant changes in liposome morphology upon treatment of liposomes containing 1 with calcium. These results showcase lipid switches driven by molecular recognition principles as an exciting avenue for controlling membrane properties. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

PubMed Central

Brereton, Melissa F.; Iberl, Michaela; Shimomura, Kenju; Zhang, Quan; Adriaenssens, Alice E.; Proks, Peter; Spiliotis, Ioannis I.; Dace, William; Mattis, Katia K.; Ramracheya, Reshma; Gribble, Fiona M.; Reimann, Frank; Clark, Anne; Rorsman, Patrik; Ashcroft, Frances M.

2014-01-01

Diabetes is characterized by hyperglycaemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The extent to which hyperglycaemia per se underlies these alterations remains poorly understood. Here we show that β-cell-specific expression of a human activating KATP channel mutation in adult mice leads to rapid diabetes and marked alterations in islet morphology, ultrastructure and gene expression. Chronic hyperglycaemia is associated with a dramatic reduction in insulin-positive cells and an increase in glucagon-positive cells in islets, without alterations in cell turnover. Furthermore, some β-cells begin expressing glucagon, whilst retaining many β-cell characteristics. Hyperglycaemia, rather than KATP channel activation, underlies these changes, as they are prevented by insulin therapy and fully reversed by sulphonylureas. Our data suggest that many changes in islet structure and function associated with diabetes are attributable to hyperglycaemia alone and are reversed when blood glucose is normalized. PMID:25145789

Relaxation of selective constraint on dog mitochondrial DNA following domestication.

PubMed

Björnerfeldt, Susanne; Webster, Matthew T; Vilà, Carles

2006-08-01

The domestication of dogs caused a dramatic change in their way of life compared with that of their ancestor, the gray wolf. We hypothesize that this new life style changed the selective forces that acted upon the species, which in turn had an effect on the dog's genome. We sequenced the complete mitochondrial DNA genome in 14 dogs, six wolves, and three coyotes. Here we show that dogs have accumulated nonsynonymous changes in mitochondrial genes at a faster rate than wolves, leading to elevated levels of variation in their proteins. This suggests that a major consequence of domestication in dogs was a general relaxation of selective constraint on their mitochondrial genome. If this change also affected other parts of the dog genome, it could have facilitated the generation of novel functional genetic diversity. This diversity could thus have contributed raw material upon which artificial selection has shaped modern breeds and may therefore be an important source of the extreme phenotypic variation present in modern-day dogs.

Oil source-fingerprinting in support of polarimetric radar mapping of Macondo-252 oil in Gulf Coast marshes

USGS Publications Warehouse

Ramsey, Elijah W.; Meyer, Buffy M.; Rangoonwala, Amina; Overton, Edward; Jones, Cathleen E.; Bannister, Terri

2014-01-01

Polarimetric synthetic aperture radar (PolSAR) data exhibited dramatic, spatially extensive changes from June 2009 to June 2010 in Barataria Bay, Louisiana. To determine whether these changes were associated with the Deepwater Horizon (DWH) oil spill, twenty-nine sediment samples were collected in 2011 from shoreline and nearshore–interior coastal marsh locations where oil was not observed visually or with optical sensors during the spill. Oil source-fingerprinting and polytopic vector analysis were used to link DWH oil to PolSAR changes. Our results prove that DWH oil extended beyond shorelines and confirm the association between presence of DWH oil and PolSAR change. These results show that the DWH oil spill probably affected much more of the southeastern Louisiana marshland than originally concluded from ground and aerial surveys and verify that PolSAR is a powerful tool for tracking oil intrusion into marshes with high probability even where contamination is not visible from above the canopy.

The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis

PubMed Central

Aldiri, Issam; Xu, Beisi; Wang, Lu; Chen, Xiang; Hiler, Daniel; Griffiths, Lyra; Valentine, Marc; Shirinifard, Abbas; Thiagarajan, Suresh; Sablauer, Andras; Barabas, Marie-Elizabeth; Zhang, Jiakun; Johnson, Dianna; Frase, Sharon; Zhou, Xin; Easton, John; Zhang, Jinghui; Mardis, Elaine R.; Wilson, Richard K.; Downing, James R.; Dyer, Michael A.

2017-01-01

SUMMARY In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order. Here we profile the epigenetic and transcriptional changes that occur during retinogenesis in mice and humans. Although some progenitor genes and cell cycle genes were epigenetically silenced during retinogenesis, the most dramatic change was derepression of cell type–specific differentiation programs. We identified developmental stage–specific super-enhancers and showed that most epigenetic changes are conserved in humans and mice. To determine how the epigenome changes during tumorigenesis and reprogramming, we performed integrated epigenetic analysis of murine and human retinoblastomas and induced pluripotent stem cells (iPSCs) derived from murine rod photoreceptors. The retinoblastoma epigenome mapped to the developmental stage when retinal progenitors switch from neurogenic to a terminal patterns of cell division. The epigenome of retinoblastomas was more similar to that of normal retina than was that of retina-derived iPSCs, and we identified retina-specific epigenetic memory. PMID:28472656

Statistical Forecasting of Current and Future Circum-Arctic Ground Temperatures and Active Layer Thickness

NASA Astrophysics Data System (ADS)

Aalto, J.; Karjalainen, O.; Hjort, J.; Luoto, M.

2018-05-01

Mean annual ground temperature (MAGT) and active layer thickness (ALT) are key to understanding the evolution of the ground thermal state across the Arctic under climate change. Here a statistical modeling approach is presented to forecast current and future circum-Arctic MAGT and ALT in relation to climatic and local environmental factors, at spatial scales unreachable with contemporary transient modeling. After deploying an ensemble of multiple statistical techniques, distance-blocked cross validation between observations and predictions suggested excellent and reasonable transferability of the MAGT and ALT models, respectively. The MAGT forecasts indicated currently suitable conditions for permafrost to prevail over an area of 15.1 ± 2.8 × 106 km2. This extent is likely to dramatically contract in the future, as the results showed consistent, but region-specific, changes in ground thermal regime due to climate change. The forecasts provide new opportunities to assess future Arctic changes in ground thermal state and biogeochemical feedback.

Structural Plasticity of Helical Nanotubes Based on Coiled-Coil Assemblies

DOE PAGES

Egelman, Edward H.; Xu, C.; DiMaio, F.; ...

2015-01-22

Numerous instances can be seen in evolution in which protein quaternary structures have diverged while the sequences of the building blocks have remained fairly conserved. However, the path through which such divergence has taken place is usually not known. We have designed two synthetic 29-residue α-helical peptides, based on the coiled-coil structural motif, that spontaneously self-assemble into helical nanotubes in vitro. Using electron cryomicroscopy with a newly available direct electron detection capability, we can achieve near-atomic resolution of these thin structures. We show how conservative changes of only one or two amino acids result in dramatic changes in quaternary structure,more » in which the assemblies can be switched between two very different forms. This system provides a framework for understanding how small sequence changes in evolution can translate into very large changes in supramolecular structure, a phenomenon that may have significant implications for the de novo design of synthetic peptide assemblies.« less

Reassessing Pliocene temperature gradients

NASA Astrophysics Data System (ADS)

Tierney, J. E.

2017-12-01

With CO2 levels similar to present, the Pliocene Warm Period (PWP) is one of our best analogs for climate change in the near future. Temperature proxy data from the PWP describe dramatically reduced zonal and meridional temperature gradients that have proved difficult to reproduce with climate model simulations. Recently, debate has emerged regarding the interpretation of the proxies used to infer Pliocene temperature gradients; these interpretations affect the magnitude of inferred change and the degree of inconsistency with existing climate model simulations of the PWP. Here, I revisit the issue using Bayesian proxy forward modeling and prediction that propagates known uncertainties in the Mg/Ca, UK'37, and TEX86 proxy systems. These new spatiotemporal predictions are quantitatively compared to PWP simulations to assess probabilistic agreement. Results show generally good agreement between existing Pliocene simulations from the PlioMIP ensemble and SST proxy data, suggesting that exotic changes in the ocean-atmosphere are not needed to explain the Pliocene climate state. Rather, the spatial changes in SST during the Pliocene are largely consistent with elevated CO2 forcing.

Surface modification of EPDM rubber by plasma treatment.

PubMed

Grythe, Kai Frode; Hansen, Finn Knut

2006-07-04

The effect of argon, oxygen, and nitrogen plasma treatment of solvent cast EPDM rubber films has been investigated by means of atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and surface energy measurements. Plasma treatment leads to changes in the surface energy from 25 to 70 mN/m. Treatment conditions influenced both the changes in surface energy and the stability, and it became more difficult to obtain good contact angle measurements after longer (> ca. 4 min) treatment times, probably because of an increasingly uneven surface structure. XPS analyses revealed that up to 20 at. % oxygen can be easily incorporated and that variations of approximately 5% can be controlled by the plasma conditions. Oxygen was mainly found in hydroxyl groups, but also as carbonyl and carboxyl. XPS analyses showed more stable surfaces than expected from contact angles, probably because XPS analysis is less surface sensitive than contact angle measurements. AFM measurements revealed different surface structures with the three gases. The surface roughness increased generally with treatment time, and dramatic changes could be observed at longer times. At short times, surface energy changes were much faster than the changes in surface structure, showing that plasma treatment conditions can be utilized to tailor both surface energies and surface structure of EPDM rubber.

Teacher Intervention to Support Oral Language and Literacy in Dramatic Play Contexts

ERIC Educational Resources Information Center

Peterson, Shelley Stagg; Greenberg, Janice

2017-01-01

A speech-language pathologist and former primary teacher who is now a researcher conducting action research with kindergarten teachers in northern rural Canadian classrooms collaborate in an analysis of one teacher's interactions with her students in a dramatic play center. We use three principles to show how the teacher supports children's…

Beryl-II, a high-pressure phase of beryl: Raman and luminescence spectroscopy to 16.4 GPa

NASA Astrophysics Data System (ADS)

O'Bannon, Earl; Williams, Quentin

2016-10-01

The Raman and Cr3+ and V2+ luminescence spectra of beryl and emerald have been characterized up to 15.0 and 16.4 GPa, respectively. The Raman spectra show that an E 1g symmetry mode at 138 cm-1 shifts negatively by -4.57 (±0.55) cm-1/GPa, and an extrapolation of the pressure dependence of this mode indicates that a soft-mode transition should occur near 12 GPa. Such a transition is in accord with prior theoretical results. Dramatic changes in Raman mode intensities and positions occur between 11.2 and 15.0 GPa. These changes are indicative of a phase transition that primarily involves tilting and mild distortion of the Si6O18 rings. New Raman modes are not observed in the high-pressure phase, which indicates that the local bonding environment is not altered dramatically across the transition (e.g., changes in coordination do not occur). Both sharp line and broadband luminescence are observed for both Cr3+ and V2+ in emerald under compression to 16.4 GPa. The R-lines of both Cr3+ and V2+ shift to lower energy (longer wavelength) under compression. Both R-lines of Cr3+ split at ~13.7 GPa, and the V2+ R1 slope changes at this pressure and shifts more rapidly up to ~16.4 GPa. The Cr3+ R-line splitting and FWHM show more complex behavior, but also shift in behavior at ~13.7 GPa. These changes in the pressure dependency of the Cr3+ and V2+ R-lines and the changes in R-line splitting and FWHM at ~13.7 GPa further demonstrate that a phase transition occurs at this pressure, in good agreement with our Raman results. The high-pressure phase of beryl appears to have two Al sites that become more regular under compression. Hysteresis is not observed in our Raman or luminescence spectra on decompression, suggesting that this transition is second order in nature: The occurrence of a second-order transition near this pressure is also in accord with prior theoretical results. We speculate that the high-pressure phase (beryl-II) might be a mildly modulated structure, and/or that extensive twinning occurs across this transition.

Mesozoic black shales, source mixing and carbon isotopes

NASA Astrophysics Data System (ADS)

Suan, Guillaume

2016-04-01

Over the last decades, considerable attention has been devoted to the paleoenvironmental and biogeochemical significance of Mesozoic black shales. Black shale-bearing successions indeed often display marked changes in the organic carbon isotope composition (δ13Corg), which have been commonly interpreted as evidence for dramatic perturbations of global carbon budgets and CO2 levels. Arguably the majority of these studies have discarded some more "local" explanations when interpreting δ13Corg profiles, most often because comparable profiles occur on geographically large and distant areas. Based on newly acquired data and selected examples from the literature, I will show that the changing contribution of organic components with distinct δ13C signatures exerts a major but overlooked influence of Mesozoic δ13Corg profiles. Such a bias occurs across a wide spectrum of sedimentological settings and ages, as shown by the good correlation between δ13Corg values and proxies of kerogen proportions (such as rock-eval, biomarker, palynofacies and palynological data) recorded in Mesozoic marginal to deep marine successions of Triassic, Jurassic and Cretaceous age. In most of these successions, labile, 12C-enriched amorphous organic matter of marine origin dominates strata deposited under anoxic conditions, while oxidation-resistant, 13C-rich terrestrial particles dominate strata deposited under well-oxygenated conditions. This influence is further illustrated by weathering profiles of Toarcian (Lower Jurassic) black shales from France, where weathered areas dominated by refractory organic matter show dramatic 13C-enrichment (and decreased total organic carbon and pyrite contents) compared to non-weathered portions of the same horizon. The implications of these results for chemostratigraphic correlations and pCO2 reconstructions of Mesozoic will be discussed, as well as strategies to overcome this major bias.

Predator stress-induced persistent emotional arousal is associated with alterations of plasma corticosterone and hippocampal steroid receptors in rat.

PubMed

Wang, Qingsong; Yu, Ke; Wang, Jun; Lin, Hang; Wu, Yuxian; Wang, Weiwen

2012-04-21

To investigate the long-term effects of psychological stress on emotionality, the emotional arousal of rats in 4 months after predator stress was assessed in both an open field environment and elevated plus maze. We also assessed the levels of plasma corticosterone (CORT) by radioimmunoassay, the distributions of brain glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) by immunohistochemistry, and the expressions of GR and MR by Western blot. The results showed that intense predator stress, which was adjusted to ensure consistent stressor intensity using rat tonic immobility behavior, successfully induced lasting decreased locomotor activity and habituation to novel environments, suppressed exploratory behavior, and increased anxiety-like behavior. The plasma CORT levels dramatically increased 1h after stress, then returned to basal levels at 1wk, decreased 1 month later, and remained significantly lower than control levels 4 months after exposure to stress. Immunohistochemical analysis showed that GR was markedly increased in the hippocampus and frontal cortexes of stressed rats and that the changes in the hippocampus were more pronounced. In contrast, MR expression was significantly decreased in both brain regions. Western analysis confirmed these dramatically elevated levels of GR expression and lower levels of MR expression in the hippocampus 4 months after stress. We conclude that acute severe psychological stress may induce long-term emotional behavioral changes, and that different patterns in plasma CORT, alterations in brain corticoid receptors, and increased hippocampal vulnerability to the effects of predator stress may play important roles in the persistent emotional arousal induced by intense psychological stress. Copyright © 2012 Elsevier B.V. All rights reserved.

Amplifying recombination genome-wide and reshaping crossover landscapes in Brassicas

PubMed Central

Falque, Matthieu; Trotoux, Gwenn; Eber, Frédérique; Nègre, Sylvie; Gilet, Marie; Huteau, Virginie; Lodé, Maryse; Jousseaume, Thibaut; Dechaumet, Sylvain; Morice, Jérôme; Coriton, Olivier; Rousseau-Gueutin, Mathieu

2017-01-01

Meiotic recombination by crossovers (COs) is tightly regulated, limiting its key role in producing genetic diversity. However, while COs are usually restricted in number and not homogenously distributed along chromosomes, we show here how to disrupt these rules in Brassica species by using allotriploid hybrids (AAC, 2n = 3x = 29), resulting from the cross between the allotetraploid rapeseed (B. napus, AACC, 2n = 4x = 38) and one of its diploid progenitors (B. rapa, AA, 2n = 2x = 20). We produced mapping populations from different genotypes of both diploid AA and triploid AAC hybrids, used as female and/or as male. Each population revealed nearly 3,000 COs that we studied with SNP markers well distributed along the A genome (on average 1 SNP per 1.25 Mbp). Compared to the case of diploids, allotriploid hybrids showed 1.7 to 3.4 times more overall COs depending on the sex of meiosis and the genetic background. Most surprisingly, we found that such a rise was always associated with (i) dramatic changes in the shape of recombination landscapes and (ii) a strong decrease of CO interference. Hybrids carrying an additional C genome exhibited COs all along the A chromosomes, even in the vicinity of centromeres that are deprived of COs in diploids as well as in most studied species. Moreover, in male allotriploid hybrids we found that Class I COs are mostly responsible for the changes of CO rates, landscapes and interference. These results offer the opportunity for geneticists and plant breeders to dramatically enhance the generation of diversity in Brassica species by disrupting the linkage drag coming from limits on number and distribution of COs. PMID:28493942

Acute and chronic gregarisation are associated with distinct DNA methylation fingerprints in desert locusts.

PubMed

Mallon, Eamonn B; Amarasinghe, Harindra E; Ott, Swidbert R

2016-10-18

Desert locusts (Schistocerca gregaria) show a dramatic form of socially induced phenotypic plasticity known as phase polyphenism. In the absence of conspecifics, locusts occur in a shy and cryptic solitarious phase. Crowding with conspecifics drives a behavioural transformation towards gregariousness that occurs within hours and is followed by changes in physiology, colouration and morphology, resulting in the full gregarious phase syndrome. We analysed methylation-sensitive amplified fragment length polymorphisms (MS-AFLP) to compare the effect of acute and chronic crowding on DNA methylation in the central nervous system. We find that crowd-reared and solitary-reared locusts show markedly different neural MS-AFLP fingerprints. However, crowding for a day resulted in neural MS-AFLP fingerprints that were clearly distinct from both crowd-reared and uncrowded solitary-reared locusts. Our results indicate that changes in DNA methylation associated with behavioural gregarisation proceed through intermediate states that are not simply partial realisations of the endpoint states.

Reconciling findings on the employment effect of disability insurance.

PubMed

Bound, John; Lindner, Stephan; Waidmann, Timothy

2014-12-01

Over the last 25 years, the Social Security Disability Insurance Program (DI) has grown dramatically. During the same period, employment rates for men with work limitations showed substantial declines in both absolute and relative terms. While the timing of these trends suggests that the expansion of DI was a major contributor to employment decline among this group, raising questions about the targeting of disability benefits, studies using denied applicants suggest a more modest role of the DI expansion. To reconcile these findings, we decompose total employment changes into population and employment changes for three categories: DI beneficiaries, denied applicants, and non-applicants. Our results show that during the early 1990s, the growth in DI can fully explain the employment decline for men only under an extreme assumption about the employment potential of beneficiaries. For the period after the mid-1990s, we find little role for the DI program in explaining the continuing employment decline for men with work limitations.

Reconciling findings on the employment effect of disability insurance

PubMed Central

Bound, John; Lindner, Stephan; Waidmann, Timothy

2016-01-01

Over the last 25 years, the Social Security Disability Insurance Program (DI) has grown dramatically. During the same period, employment rates for men with work limitations showed substantial declines in both absolute and relative terms. While the timing of these trends suggests that the expansion of DI was a major contributor to employment decline among this group, raising questions about the targeting of disability benefits, studies using denied applicants suggest a more modest role of the DI expansion. To reconcile these findings, we decompose total employment changes into population and employment changes for three categories: DI beneficiaries, denied applicants, and non-applicants. Our results show that during the early 1990s, the growth in DI can fully explain the employment decline for men only under an extreme assumption about the employment potential of beneficiaries. For the period after the mid-1990s, we find little role for the DI program in explaining the continuing employment decline for men with work limitations. PMID:27158580

Evidence for 20th century climate warming and wetland drying in the North American Prairie Pothole Region

USGS Publications Warehouse

Werner, B.A.; Johnson, W. Carter; Guntenspergen, Glenn R.

2013-01-01

The Prairie Pothole Region (PPR) of North America is a globally important resource that provides abundant and valuable ecosystem goods and services in the form of biodiversity, groundwater recharge, water purification, flood attenuation, and water and forage for agriculture. Numerous studies have found these wetlands, which number in the millions, to be highly sensitive to climate variability. Here, we compare wetland conditions between two 30-year periods (1946–1975; 1976–2005) using a hindcast simulation approach to determine if recent climate warming in the region has already resulted in changes in wetland condition. Simulations using the WETLANDSCAPE model show that 20th century climate change may have been sufficient to have a significant impact on wetland cover cycling. Modeled wetlands in the PPR's western Canadian prairies show the most dramatic effects: a recent trend toward shorter hydroperiods and less dynamic vegetation cycles, which already may have reduced the productivity of hundreds of wetland-dependent species.

Evidence for 20th century climate warming and wetland drying in the North American Prairie Pothole Region.

PubMed

Werner, Brett A; Johnson, W Carter; Guntenspergen, Glenn R

2013-09-01

The Prairie Pothole Region (PPR) of North America is a globally important resource that provides abundant and valuable ecosystem goods and services in the form of biodiversity, groundwater recharge, water purification, flood attenuation, and water and forage for agriculture. Numerous studies have found these wetlands, which number in the millions, to be highly sensitive to climate variability. Here, we compare wetland conditions between two 30-year periods (1946-1975; 1976-2005) using a hindcast simulation approach to determine if recent climate warming in the region has already resulted in changes in wetland condition. Simulations using the WETLANDSCAPE model show that 20th century climate change may have been sufficient to have a significant impact on wetland cover cycling. Modeled wetlands in the PPR's western Canadian prairies show the most dramatic effects: a recent trend toward shorter hydroperiods and less dynamic vegetation cycles, which already may have reduced the productivity of hundreds of wetland-dependent species.

Evolution of the Crop Rhizosphere: Impact of Domestication on Root Exudates in Tetraploid Wheat (Triticum turgidum L.)

PubMed Central

Iannucci, Anna; Fragasso, Mariagiovanna; Beleggia, Romina; Nigro, Franca; Papa, Roberto

2017-01-01

Domestication has induced major genetic changes in crop plants to satisfy human needs and as a consequence of adaptation to agroecosystems. This adaptation might have affected root exudate composition, which can influence the interactions in the rhizosphere. Here, using two different soil types (sand, soil), we provide an original example of the impact of domestication and crop evolution on root exudate composition through metabolite profiling of root exudates for a panel of 10 wheat genotypes that correspond to the key steps in domestication of tetraploid wheat (wild emmer, emmer, durum wheat). Our data show that soil type can dramatically affect the composition of root exudates in the rhizosphere. Moreover, the composition of the rhizosphere metabolites is associated with differences among the genotypes of the wheat domestication groups, as seen by the high heritability of some of the metabolites. Overall, we show that domestication and breeding have had major effects on root exudates in the rhizosphere, which suggests the adaptive nature of these changes. PMID:29326736

CHOICE OF INDICATOR DETERMINES THE SIGNIFICANCE AND RISK OBTAINED FROM THE STATISTICAL ASSOCIATION BETWEN FINE PARTICULATE MATTER MASS AND CARDIOVASCULAR MORTALITY

EPA Science Inventory

Minor changes in the indicator used to measure fine PM, which cause only modest changes in Mass concentrations, can lead to dramatic changes in the statistical relationship of fine PM mass with cardiovascular mortality. An epidemiologic study in Phoenix (Mar et al., 2000), augme...

An emergent disease causes directional changes in forest species composition in coastal California

Treesearch

Margaret Metz; Kerri Frangioso; Allison Wickland; Ross Meentemeyer; David Rizzo

2012-01-01

Non-native forest pathogens can cause dramatic and long-lasting changes to the composition of forests, and these changes may have cascading impacts on community interactions and ecosystem functioning. Phytophthora ramorum, the causal agent of the emergent forest disease sudden oak death (SOD), has a wide host range, but mortality is concentrated in...

The Debate Continues: Further Evidence of Discontinuity in Dewey's Philosophy.

ERIC Educational Resources Information Center

Prawat, Richard S.

2003-01-01

Responds to a critique of a thesis that Dewey underwent a dramatic midcareer change in his philosophy and that this change drew heavily on Pierce's metaphysics, offering additional evidence to support the claim that comparison of the 1910 and 1933 versions of "How We Think" reveals a major change in Dewey's views about inductionism. New…

Creating the Future: Essays on Librarianship in an Age of Great Change.

ERIC Educational Resources Information Center

Reed, Sally Gardner, Ed.

Librarianship is in a period of great transition. Expanding uses of information technology and a dramatically changing demographic and economic environment are forcing librarians to re-examine their profession and to ask questions about their future relevance and viability. Change is and should be viewed as an ongoing and critical component of…

Hox3/zen and the evolution of extraembryonic epithelia in insects.

PubMed

Schmidt-Ott, Urs; Rafiqi, Ab Matteen; Lemke, Steffen

2010-01-01

Insects have undergone dramatic evolutionary changes in extraembryonic development, which correlate with changes in the expression of the class-3 Hox gene zen. Here, we review the evolution of this gene in insects and point out how changes in zen expression may have affected extraembryonic development at the morphological and the genetic level.

The Gap between Expectations and Reality: Integrating Computers into Mathematics Classrooms

ERIC Educational Resources Information Center

Guven, Bulent; Cakiroglu, Unal; Akkan, Yasar

2009-01-01

As a result of dramatic changes in mathematics education around the world, in Turkey both elementary and secondary school mathematics curriculums have changed in the light of new demands since 2005. In order to perform the expected change in newly developed curriculum, computer should be integrated into learning and teaching process. Teachers'…

Essentialist Reasoning and Knowledge Effects on Biological Reasoning in Young Children

ERIC Educational Resources Information Center

Herrmann, Patricia A.; French, Jason A.; DeHart, Ganie B.; Rosengren, Karl S.

2013-01-01

Biological kinds undergo a variety of changes during their life span, and these changes vary in degree by organism. Understanding that an organism, such as a caterpillar, maintains category identity over its life span despite dramatic changes is a key concept in biological reasoning. At present, we know little about the developmental trajectory of…

Taking Up the Security Challenge of Climate Change

DTIC Science & Technology

2009-05-26

Climate change , in which man-made global warming is a major factor, will likely have dramatic and long-lasting consequences with profound security...effects of climate change are greatest, particularly in weak states that are already vulnerable to environmental destabilization. Two things are vitally...important: stemming the tide of climate change and adapting to its far-reaching consequences. This project examines the destabilizing effects of climate

Understanding and monitoring the consequences of human impacts on intraspecific variation.

PubMed

Mimura, Makiko; Yahara, Tetsukazu; Faith, Daniel P; Vázquez-Domínguez, Ella; Colautti, Robert I; Araki, Hitoshi; Javadi, Firouzeh; Núñez-Farfán, Juan; Mori, Akira S; Zhou, Shiliang; Hollingsworth, Peter M; Neaves, Linda E; Fukano, Yuya; Smith, Gideon F; Sato, Yo-Ichiro; Tachida, Hidenori; Hendry, Andrew P

2017-02-01

Intraspecific variation is a major component of biodiversity, yet it has received relatively little attention from governmental and nongovernmental organizations, especially with regard to conservation plans and the management of wild species. This omission is ill-advised because phenotypic and genetic variations within and among populations can have dramatic effects on ecological and evolutionary processes, including responses to environmental change, the maintenance of species diversity, and ecological stability and resilience. At the same time, environmental changes associated with many human activities, such as land use and climate change, have dramatic and often negative impacts on intraspecific variation. We argue for the need for local, regional, and global programs to monitor intraspecific genetic variation. We suggest that such monitoring should include two main strategies: (i) intensive monitoring of multiple types of genetic variation in selected species and (ii) broad-brush modeling for representative species for predicting changes in variation as a function of changes in population size and range extent. Overall, we call for collaborative efforts to initiate the urgently needed monitoring of intraspecific variation.

Accessible ecology: Synthesis of the long, deep, and broad

USDA-ARS?s Scientific Manuscript database

Dramatic changes in climate, land cover, and habitat availability have occurred over the past several centuries to influence every ecosystem on Earth. Large amounts of data have been collected to document changes. Solutions to these environmental problems have been more elusive, in large part becaus...

Becoming Citizens of the World

ERIC Educational Resources Information Center

Stewart, Vivien

2007-01-01

The globalization of economies, the digitization of work, pressing health and security issues, and changing demographics have dramatically changed our world. Unlike previous generations, U.S. high school graduates will routinely buy from the world, sell to the world, work for international companies, manage employees from other cultures and…

College Psychiatry 2006: Challenges and Opportunities

ERIC Educational Resources Information Center

Kadison, Richard

2006-01-01

This article discusses some of the dramatic changes seen in college mental health issues over the past 2 decades. These modifications are a consequence of many factors: changes in our health care system (managed care), new effective biological treatments (medications), the focus of psychiatric training (biologic focus), technology advances…

Illuminating the Way.

ERIC Educational Resources Information Center

Murphy, Peter

1997-01-01

Details the dramatic changes in school lighting. Describes how lighting will be more closely integrated into the "smart" school building of tomorrow and how lighting systems will evolve with schools as technology changes. Claims that direct/indirect lighting systems will serve computer users as well as reduce energy and maintenance costs. (RJM)

Tenure Wild Cards

ERIC Educational Resources Information Center

Zemsky, Robert

2008-01-01

The circumstances of tenure have changed and will likely continue to change, perhaps even dramatically. The proportion of university and college faculty members with full academic qualifications--which usually means those with earned doctorates--who either have tenure or are serving a probationary period for tenure has been declining steadily over…

Growth and Your 13-to 18-Year-Old

MedlinePlus

... is a time of dramatic change for both boys and girls. Hormone-driven changes are accompanied by growth spurts ... ages 12 and 15. The growth spurt of boys is, on average, about 2 years later than that of girls. By age 16, most boys have stopped growing, ...

The Dilemmas of Educational Reform

ERIC Educational Resources Information Center

Cohen, David K.; Spillane, James P.; Peurach, Donald J.

2018-01-01

The environment of U.S. schools has changed dramatically over a quarter century as standards tied to test-based accountability and market competition became commonplace. We examine the issues that school systems face in this changing environment, to identify considerations for researchers interested in reform as educational system building. We…

Student Services: A Student's Eye View

ERIC Educational Resources Information Center

Runnals, Angela

2006-01-01

Simon Fraser University in Vancouver, British Columbia (BC), celebrated its fortieth anniversary in 2005. A relatively new university, it has nevertheless seen tremendous changes over the past four decades. As admissions officers, registrars and other student services professionals know, the rate of change is continuing to increase dramatically.…

75 FR 30383 - NOAA's Arctic Vision and Strategy; Comment Period Extension

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-01

... evidence of widespread and dramatic ongoing change. As a result, critical environmental, economic, and... public comment period by fifteen days. The Arctic has profound significance for climate and functioning of ecosystems around the globe. The region is particularly vulnerable and prone to rapid change...

Terrestrial ecosystems and their change

Treesearch

Anatoly Z. Shvidenko; Eric Gustafson; A. David McGuire; Vjacheslav I. Kharuk; Dmitry G. Schepaschenko; Herman H. Shugart; Nadezhda M. Tchebakova; Natalia N. Vygodskaya; Alexander A. Onuchin; Daniel J. Hayes; Ian McCallum; Shamil Maksyutov; Ludmila V. Mukhortova; Amber J. Soja; Luca Belelli-Marchesini; Julia A. Kurbatova; Alexander V. Oltchev; Elena I. Parfenova; Jacquelyn K. Shuman

2012-01-01

This chapter considers the current state of Siberian terrestrial ecosystems, their spatial distribution, and major biometric characteristics. Ongoing climate change and the dramatic increase of accompanying anthropogenic pressure provide different but mostly negative impacts on Siberian ecosystems. Future climates of the region may lead to substantial drying on large...

NGC 2617 brightens again after long very low state

NASA Astrophysics Data System (ADS)

Oknyansky, V.; Lipunov, V. M.; Shatsky, N. I.; Gorbovskoy, E. S.; Tatarnikov, A. M.; Metlov, V. G.; Burlak, M. A.; Gaskell, C. M.; Huseynov, N. A.; Mikailov, Kh. M.; Alekberov, I. A.; Tsygankov, S. S.; Brotherton, M. B.; Kasper, D.; Du, P.; Chen, X.; Buckley, D. A. H.; Winkler, H.; Paul, B.; van Wyk, F.; Rebolo, R.; Serra-Ricart, M.; Podesta, R.; Levato, H.

2018-06-01

NGC 2617 is typical example of a changing-look AGN. It has been observed to undergo a dramatic change from a largely obscured Seyfert 1.8 to an unobscured Seyfert 1 from 2003 to 2013 (Shappee et al. 2013, ATel #5010, Shappee et al. 2014).

Air Pollution: Current and Future Challenges

EPA Pesticide Factsheets

Despite the dramatic progress to date, air pollution continues to threaten Americans’ health and welfare. The main obstacles are climate change, conventional air pollution, and ozone layer depletion.

Level-tolerant duration selectivity in the auditory cortex of the velvety free-tailed bat Molossus molossus.

PubMed

Macías, Silvio; Hernández-Abad, Annette; Hechavarría, Julio C; Kössl, Manfred; Mora, Emanuel C

2015-05-01

It has been reported previously that in the inferior colliculus of the bat Molossus molossus, neuronal duration tuning is ambiguous because the tuning type of the neurons dramatically changes with the sound level. In the present study, duration tuning was examined in the auditory cortex of M. molossus to describe if it is as ambiguous as the collicular tuning. From a population of 174 cortical 104 (60 %) neurons did not show duration selectivity (all-pass). Around 5 % (9 units) responded preferentially to stimuli having longer durations showing long-pass duration response functions, 35 (20 %) responded to a narrow range of stimulus durations showing band-pass duration response functions, 24 (14 %) responded most strongly to short stimulus durations showing short-pass duration response functions and two neurons (1 %) responded best to two different stimulus durations showing a two-peaked duration-response function. The majority of neurons showing short- (16 out of 24) and band-pass (24 out 35) selectivity displayed "O-shaped" duration response areas. In contrast to the inferior colliculus, duration tuning in the auditory cortex of M. molossus appears level tolerant. That is, the type of duration selectivity and the stimulus duration eliciting the maximum response were unaffected by changing sound level.

Assessment of climate impacts on the karst-related carbon sink in SW China using MPD and GIS

NASA Astrophysics Data System (ADS)

Zeng, Sibo; Jiang, Yongjun; Liu, Zaihua

2016-09-01

Riverine carbon fluxes of some catchments in the world have significantly changed due to contemporary climate change and human activities. As a large region with an extensive karstic area of nearly 7.5 × 105 km2, Southwest (SW) China has experienced dramatic climate changes during recent decades. Although some studies have investigated the karst-related carbon sink in some parts of this region, the importance of climate impacts have not been assessed. This research examined the impacts of recent climate change on the karst-related carbon sink in the SW China for the period 1970-2013, using a modified maximal potential dissolution (MPD) method and GIS. We first analyzed the major determinants of carbonate dissolution at a spatial scale, calculated the total karst-related carbon sink (TCS) and carbon sink fluxes (CSFs) in the SW China karst region with different types of carbonate rocks, and then compared with other methods, and analyzed the causes of CSFs variations under the changed climate conditions. The results show that the TCS in SW China experienced a dramatic change with regional climate, and there was a trend with TCS decreasing by about 19% from 1970s to 2010s. This decrease occurred mostly in Guizhou and Yunnan provinces, which experienced larger decreases in runoff depth in the past 40 years (190 mm and 90 mm, respectively) due to increased air temperature (0.33 °C and 1.04 °C, respectively) and decreased precipitation (156 mm and 106 mm, respectively). The mean value of CSFs in SW China, calculated by the modified MPD method, was approximately 9.36 t C km- 2 a- 1. In addition, there were large differences in CSFs among the provinces, attributed to differences in regional climate and to carbonate lithologies. These spatiotemporal changes depended mainly on hydrological variations (i.e., discharge or runoff depth). This work, thus, suggests that the karst-related carbon sink could respond to future climate change quickly, and needs to be considered in the modern global carbon cycle model.

In situ NMR spectroscopy of supercapacitors: insight into the charge storage mechanism.

PubMed

Wang, Hao; Forse, Alexander C; Griffin, John M; Trease, Nicole M; Trognko, Lorie; Taberna, Pierre-Louis; Simon, Patrice; Grey, Clare P

2013-12-18

Electrochemical capacitors, commonly known as supercapacitors, are important energy storage devices with high power capabilities and long cycle lives. Here we report the development and application of in situ nuclear magnetic resonance (NMR) methodologies to study changes at the electrode-electrolyte interface in working devices as they charge and discharge. For a supercapacitor comprising activated carbon electrodes and an organic electrolyte, NMR experiments carried out at different charge states allow quantification of the number of charge storing species and show that there are at least two distinct charge storage regimes. At cell voltages below 0.75 V, electrolyte anions are increasingly desorbed from the carbon micropores at the negative electrode, while at the positive electrode there is little change in the number of anions that are adsorbed as the voltage is increased. However, above a cell voltage of 0.75 V, dramatic increases in the amount of adsorbed anions in the positive electrode are observed while anions continue to be desorbed at the negative electrode. NMR experiments with simultaneous cyclic voltammetry show that supercapacitor charging causes marked changes to the local environments of charge storing species, with periodic changes of their chemical shift observed. NMR calculations on a model carbon fragment show that the addition and removal of electrons from a delocalized system should lead to considerable increases in the nucleus-independent chemical shift of nearby species, in agreement with our experimental observations.

In Situ NMR Spectroscopy of Supercapacitors: Insight into the Charge Storage Mechanism

PubMed Central

2013-01-01

Electrochemical capacitors, commonly known as supercapacitors, are important energy storage devices with high power capabilities and long cycle lives. Here we report the development and application of in situ nuclear magnetic resonance (NMR) methodologies to study changes at the electrode–electrolyte interface in working devices as they charge and discharge. For a supercapacitor comprising activated carbon electrodes and an organic electrolyte, NMR experiments carried out at different charge states allow quantification of the number of charge storing species and show that there are at least two distinct charge storage regimes. At cell voltages below 0.75 V, electrolyte anions are increasingly desorbed from the carbon micropores at the negative electrode, while at the positive electrode there is little change in the number of anions that are adsorbed as the voltage is increased. However, above a cell voltage of 0.75 V, dramatic increases in the amount of adsorbed anions in the positive electrode are observed while anions continue to be desorbed at the negative electrode. NMR experiments with simultaneous cyclic voltammetry show that supercapacitor charging causes marked changes to the local environments of charge storing species, with periodic changes of their chemical shift observed. NMR calculations on a model carbon fragment show that the addition and removal of electrons from a delocalized system should lead to considerable increases in the nucleus-independent chemical shift of nearby species, in agreement with our experimental observations. PMID:24274637

Criticality triggers the emergence of collective intelligence in groups.

PubMed

De Vincenzo, Ilario; Giannoccaro, Ilaria; Carbone, Giuseppe; Grigolini, Paolo

2017-08-01

A spinlike model mimicking human behavior in groups is employed to investigate the dynamics of the decision-making process. Within the model, the temporal evolution of the state of systems is governed by a time-continuous Markov chain. The transition rates of the resulting master equation are defined in terms of the change of interaction energy between the neighboring agents (change of the level of conflict) and the change of a locally defined agent fitness. Three control parameters can be identified: (i) the social interaction strength βJ measured in units of social temperature, (ii) the level of confidence β^{'} that each individual has on his own expertise, and (iii) the level of knowledge p that identifies the expertise of each member. Based on these three parameters, the phase diagrams of the system show that a critical transition front exists where a sharp and concurrent change in fitness and consensus takes place. We show that at the critical front, the information leakage from the fitness landscape to the agents is maximized. This event triggers the emergence of the collective intelligence of the group, and in the end it leads to a dramatic improvement in the decision-making performance of the group. The effect of size M of the system is also investigated, showing that, depending on the value of the control parameters, increasing M may be either beneficial or detrimental.

Criticality triggers the emergence of collective intelligence in groups

NASA Astrophysics Data System (ADS)

De Vincenzo, Ilario; Giannoccaro, Ilaria; Carbone, Giuseppe; Grigolini, Paolo

2017-08-01

A spinlike model mimicking human behavior in groups is employed to investigate the dynamics of the decision-making process. Within the model, the temporal evolution of the state of systems is governed by a time-continuous Markov chain. The transition rates of the resulting master equation are defined in terms of the change of interaction energy between the neighboring agents (change of the level of conflict) and the change of a locally defined agent fitness. Three control parameters can be identified: (i) the social interaction strength β J measured in units of social temperature, (ii) the level of confidence β' that each individual has on his own expertise, and (iii) the level of knowledge p that identifies the expertise of each member. Based on these three parameters, the phase diagrams of the system show that a critical transition front exists where a sharp and concurrent change in fitness and consensus takes place. We show that at the critical front, the information leakage from the fitness landscape to the agents is maximized. This event triggers the emergence of the collective intelligence of the group, and in the end it leads to a dramatic improvement in the decision-making performance of the group. The effect of size M of the system is also investigated, showing that, depending on the value of the control parameters, increasing M may be either beneficial or detrimental.

Reemergence of sea ice cover anomalies and the role of the sea ice-albedo feedback in CCSM simulations

NASA Astrophysics Data System (ADS)

Deweaver, E. T.

2008-12-01

The dramatic sea ice decline of 2007 and lack of recovery in 2008 raise the question of a "tipping point" for Arctic sea ice, beyond which the transition to a seasonal sea ice state becomes abrupt and irreversible. The tipping point is essentially a "memory catastrophe", in which a dramatic loss of sea ice in one summer is "remembered" in reduced ice thickness over the winter season and leads to a comparably dramatic loss the following summer. The dominant contributor to this memory is presumably the sea ice - albedo feedback (SIAF), in which excess insolation absorbed due to low summer ice cover leads to a shorter ice growth season and hence thinner ice. While these dynamics are clearly important, they are difficult to quantify given the lack of long-term observations in the Arctic and the suddenness of the recent loss. Alternatively, we attempt to quantify the contribution of the SIAF to the year-to-year memory of sea ice cover anomalies in simulations of the NCAR Community Climate System Model (CCSM) under 20th century conditions. Lagged autocorrelation plots of sea ice area anomalies show that anomalies in one year tend to "reemerge" in the following year. Further experiments using a slab ocean model (SOM) are used to assess the contribution of oceanic processes to the year-to-year reemergence. This contribution is substantial, particularly in the winter season, and includes memory due to the standard mixed layer reemergence mechanism and low-frequency ocean heat transport anomalies. The contribution of the SIAF to persistence in the SOM experiment is determined through additional experiments in which the SIAF is disabled by fixing surface albedo to its climatological value regardless of sea ice concentration anomalies. SIAF causes a 50% increase in the magnitude of the anomalies but a relatively small increase in their persistence. Persistence is not dramatically increased because the enhancement of shortwave flux anomalies by SIAF is compensated by stronger turbulent heat flux losses in the cold season. The role of turbulent heat fluxes is somewhat inconsistent with the retrospective 20th century simulations from PIOMAS, in which increased insolation is balanced by longwave heat loss. By fitting the area anomaly time series for the SIAF and no-SIAF integrations to an AR1 process, the change in net feedback due to SIAF is calculated. The change in net feedback implies that SIAF increases the climate sensitivity of September sea ice to external forcing (greenhouse gas increases) by about 20%. The modest increase in sea ice sensitivity is confirmed by further climate change experiments with and without SIAF with the CCSM/SOM model. The small role for SIAF is somewhat surprising given the prevalence of "abrupt loss" events in CCSM climate change simulations. However, it is consistent with claims that the dominant factor in abrupt loss events is the sea ice thickness at the event onset.

Corporatizing Higher Education

ERIC Educational Resources Information Center

Lerner, Gerda

2008-01-01

The process of changing U.S. higher education institutions along a corporate model has been going on for several decades. It consists of changes, some open, some obscured, on various fronts: the erosion of tenure by attrition; the simultaneous increase in the use of contingent faculty; the rise in tuition; the dramatic decrease in federal and…

Implementation Recommendations for School Districts. GASB Statement No. 34.

ERIC Educational Resources Information Center

Association of School Business Officials International, Reston, VA.

Statement 34 is the most significant change in the history of governmental accounting. It is a dramatic change in the way school districts report and present financial information. This new reporting model affects every public-school organization that issues financial statements in conformity with generally accepted accounting principles (GAAP).…

Feminism Vis a Vis Social Change.

ERIC Educational Resources Information Center

Adickes, Sandra

While demonstrating the potential of feminist education to promote positive social change, experiences with the women's studies programs at Staten Island Community College (SICC) and Brooklyn College (BC) also dramatize the need for women's studies to overcome factionalism and middle-class elitism in order to construct a pedagogy for oppressed…

Neoliberalism, Policy Reforms and Higher Education in Bangladesh

ERIC Educational Resources Information Center

Kabir, Ariful Haq

2013-01-01

Bangladesh has introduced neoliberal policies since the 1970s. Military regimes, since the dramatic political changes in 1975, accelerated the process. A succession of military rulers made rigorous changes in policy-making in various sectors. This article uses a critical approach to document analysis and examines the perceptions of key…

Business-Industry-Labor Involvement in Lifelong Vocational-Technical Education.

ERIC Educational Resources Information Center

Warmbrod, Catharine P.

The knowledge explosion dramatizes the need for education throughout peoples' lives, while technological change in particular fuels business, industry, and labor's imperative to cooperate closely with education to prepare people for work. In order to obtain the training, retraining, upgrading, and recycling of persons and skills, changes in work…

Education as a Social Control Mechanism.

ERIC Educational Resources Information Center

Bacchus, M. K.

1979-01-01

With the abolition of slavery, most West Indian planters dramatically changed their attitudes toward education for Blacks, suddenly favoring it. This paper examines reasons behind the attitudinal changes, the planters' perceptions on the role of education for Blacks, and the use of education as a mechanism for social control. (DS)

Maximizing Empower on a Human-dominated Planet: The Role of Exotic Spartina (Eco Eng.)

EPA Science Inventory

The emergy signature of the Earth has changed dramatically over the past 250 years as a result of the development of technologies to use fossil fuels for human purposes. This change has resulted in the self-organization of modern industrial societies and their concomitant process...

Helping Students Visualize the Process of Change with Historic Images

ERIC Educational Resources Information Center

Wesson, Stephen; Lederle, Cheryl

2013-01-01

Public protests. Sensational headlines. Scathing editorial cartoons. Sloganeering posters. Are these signs of upheaval and disorder? Or are they evidence of a healthy public debate--one that could lead to legislation dramatically changing American life? In this article, the authors incorporate historical photographs taken by Lewis Hine between…

The State of Organic Teaching Laboratories

ERIC Educational Resources Information Center

Horowitz, Gail

2007-01-01

The changes that have taken place in the organic chemistry laboratory course since 1980s are reviewed with reference to the quantity and diversity of discovery-based experiments available to date. The data illustrates that significant progress is towards accomplishing dramatic changes such as the almost universal adoption of microscale, the use of…

Teacher Education beyond Transmission: Challenges and Opportunities for Iranian Teachers of English

ERIC Educational Resources Information Center

Safari, Parvin; Rashidi, Nasser

2015-01-01

The teacher education field has recently undergone dramatic changes leading to a shift of focus from transmission models towards alternative approaches and theories that emerged in the post-transmission era addressing sociocultural, political, ideological, and critical issues. Despite worldwide changes in teacher education programs, it seems that…

Dissertation Genre Change as a Result of Electronic Theses and Dissertation Programs

ERIC Educational Resources Information Center

Pantelides, Kate

2015-01-01

The increasing prevalence of mandatory Electronic Theses and Dissertations (ETDs) policies has ushered in rather dramatic dissertation genre change. The affordances of the medium offer expanded access and audience, availability of new compositional tools, and alternate formats, the implications of which are just beginning to appear in…

Transitions in U.S. Higher Education: Implications for Geography Learning

ERIC Educational Resources Information Center

Nellis, M. Duane

2017-01-01

In the United States, higher education institutions and structures governing higher education are going through dramatic change. The implications of new technology and changing modes of course structure, and evolving federal and state policies have the potential for significant impact on higher education. The historic federal mandates regarding…

Navigating Disruptive Innovation in Undergraduate Business Education

ERIC Educational Resources Information Center

Behara, Ravi S.; Davis, Mark M.

2015-01-01

The undergraduate business education landscape is dramatically changing and will continue to do so for the foreseeable future. Many of the changes are being driven by increasing costs, advances in technology, rapid globalization, and an increasingly diverse workforce and customer base, and are occurring simultaneously in both the business world…

The Changing American Diet.

ERIC Educational Resources Information Center

Brewster, Letitia; Jacobson, Michael F.

This book presents an overview of Americans' eating habits in the present and the early 1900's. Chapter One discusses factors contributing to the nation's dramatic, almost unprecedented dietary changes and provides a brief discussion of food consumption statistics. Chapter Two compares present and past U.S. consumption of alcoholic beverages,…

Voices from southern forests

Treesearch

H. Ken Cordell; John C. Bliss; Cassandra Y. Johnson; Mark Fly

1998-01-01

The faces and voices of the South have been changing dramatically over the last several decades, just like the rest of the Nation. Population growth, immigration, urbanization, expanding minority proportions, a thriving economy, rising environmental sentiments, and shifts in property ownership, among many other changes, have put forest and wildlife management in a much...

"Somehow, I Don't Think 'They' Were Expecting 'Us'": The Changing Religious Landscapes for Universities

ERIC Educational Resources Information Center

Cooper Nelson, Janet M.

2013-01-01

The sacred contours of the nation's colleges and universities changed dramatically since their founding--new human architecture and vocabulary compelled radical reformation of curriculum, policy, and accommodation. But institutional histories and culture remain eloquent and powerful. New competences in religious literacy and convictional identity…

The Co-Development of Looking Dynamics and Discrimination Performance

ERIC Educational Resources Information Center

Perone, Sammy; Spencer, John P.

2014-01-01

The study of looking dynamics and discrimination form the backbone of developmental science and are central processes in theories of infant cognition. Looking dynamics and discrimination change dramatically across the 1st year of life. Surprisingly, developmental changes in looking and discrimination have not been studied together. Recent…

A Cooperative Classroom Investigation of Climate Change

ERIC Educational Resources Information Center

Constible, Juanita; Sandro, Luke; Lee, Richard E., Jr.

2007-01-01

Scientists have a particularly difficult time explaining warming trends in Antarctica--a region with a relatively short history of scientific observation and a highly variable climate (Clarke et al. 2007). Regardless of the mechanism of warming, however, climate change is having a dramatic impact on Antarctic ecosystems. In this article, the…

DEVELOPMENT OF NITROGEN LOADING-RESPONSE RELATIONSHIPS FOR ESTUARINE WATERS USING AN EMPIRICAL COMPARATIVE SYSTEMS APPROACH

EPA Science Inventory

There is growing evidence that human activities have dramatically changed the amounts, distribution, and movement of major nutrient elements (nitrogen-N and phosphorus-P) in the landscape and have increased nutrient loading to receiving waters. Some of these changes affect use o...

Developing a field and cyberinfrastructure to study land-atmosphere interactions in the Chihuahuan Desert

USDA-ARS?s Scientific Manuscript database

Chihuahuan desert landscapes are representative of many arid and semiarid ecosystems of the world where dramatic changes in vegetation structure and ecosystem processes have occurred over the past several centuries. These changes in ecosystem state are often interpreted as “desertification”, the bro...

Producing edible landscapes in Seattle's urban forest

Treesearch

Rebecca McLain; Melissa Poe; Patrick T. Hurley; Joyce Lecompte-Mastenbrook; Marla R. Emery

2012-01-01

Over the next decades, green infrastructure initiatives such as tree planting campaigns, and ecological restoration will dramatically change the species composition, species distribution and structure of urban forests across the United States. These impending changes are accompanied by a demand for urban public spaces where people can engage in practices such as...

Changes in Attitudes among College Economics Students about the Fairness of the Market.

ERIC Educational Resources Information Center

Whaples, Robert

1995-01-01

Charts the changes in student opinions, regarding the fairness of pricing and profits, from beginning to end of a first-year college economics course. Students answered morally ambiguous questions involving product markets and prices. Student belief in the fairness of free market pricing increased dramatically. (MJP)

Today's Changing Families and their Needs.

ERIC Educational Resources Information Center

Thierman, Susan B.

This paper discusses the changing concept of the American family, identifying four major trends in family structure: (1) a dramatic increase in two-wage-earner families; (2) more working women; (3) more single-parent families; and (4) restructuring of families through divorces and remarriages. The family has been losing many of its traditional…

Argumentation in a Changing World

ERIC Educational Resources Information Center

Schwarz, Baruch B.; De Groot, Reuma

2007-01-01

Critical reasoning has been recognized as a valuable educational goal since the end of the nineteenth century. However, the educational programs to reach this goal have changed dramatically during the twentieth century and moved to a dialogic approach. The shift to dialogism in programs to promote critical reasoning brings challenges concerning…

Monetary Policy after August 2007

ERIC Educational Resources Information Center

Gertler, Mark

2013-01-01

In this article, the author describes conceptually how to think about the dramatic changes in monetary policy since the sub-prime crisis of August 2007. He also discusses how to incorporate these changes and related economic concepts in the teaching of an undergraduate class in macroeconomics. A distinction is made between conventional and…

Assessing the effects of changes in land use and climate on runoff and sediment yields from a watershed in the Loess Plateau of China.

PubMed

Zuo, Depeng; Xu, Zongxue; Yao, Wenyi; Jin, Shuangyan; Xiao, Peiqing; Ran, Dachuan

2016-02-15

The changes in runoff and sediment load in the Loess Plateau of China have received considerable attention owing to their dramatic decline during recent decades. In this paper, the impacts of land-use and climate changes on water and sediment yields in the Huangfuchuan River basin (HFCRB) of the Loess Plateau are investigated by combined usage of statistical tests, hydrological modeling, and land-use maps. The temporal trends and abrupt changes in runoff and sediment loads during 1954-2012 are detected by using non-parametric Mann-Kendall and Pettitt tests. The land-use changes between 1980 and 2005 are determined by using transition matrix analysis, and the effects of land-use and climate changes on water and sediment yields are assessed by using the Soil and Water Assessment Tool (SWAT) hydrological model and four scenarios, respectively. The results show significant decreasing trends in both annual runoff and sediment loads, whereas slightly decreasing and significantly increasing trends are detected for annual precipitation and air temperature, respectively. 1984 is identified as the dividing year of the study period. The land-use changes between 1980 and 2005 show significant effects of the Grain for Green Project in China. Both land-use change and climate change have greater impact on the reduction of sediment yield than that of water. Water and sediment yields in the upstream region show more significant decreases than those in the downstream region under different effects. The results obtained in this study can provide useful information for water resource planning and management as well as soil and water conservation in the Loess Plateau region. Copyright © 2015 Elsevier B.V. All rights reserved.

Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life

PubMed Central

Sojo, Victor; Dessimoz, Christophe; Pomiankowski, Andrew; Lane, Nick

2016-01-01

Membrane proteins are crucial in transport, signaling, bioenergetics, catalysis, and as drug targets. Here, we show that membrane proteins have dramatically fewer detectable orthologs than water-soluble proteins, less than half in most species analyzed. This sparse distribution could reflect rapid divergence or gene loss. We find that both mechanisms operate. First, membrane proteins evolve faster than water-soluble proteins, particularly in their exterior-facing portions. Second, we demonstrate that predicted ancestral membrane proteins are preferentially lost compared with water-soluble proteins in closely related species of archaea and bacteria. These patterns are consistent across the whole tree of life, and in each of the three domains of archaea, bacteria, and eukaryotes. Our findings point to a fundamental evolutionary principle: membrane proteins evolve faster due to stronger adaptive selection in changing environments, whereas cytosolic proteins are under more stringent purifying selection in the homeostatic interior of the cell. This effect should be strongest in prokaryotes, weaker in unicellular eukaryotes (with intracellular membranes), and weakest in multicellular eukaryotes (with extracellular homeostasis). We demonstrate that this is indeed the case. Similarly, we show that extracellular water-soluble proteins exhibit an even stronger pattern of low homology than membrane proteins. These striking differences in conservation of membrane proteins versus water-soluble proteins have important implications for evolution and medicine. PMID:27501943

Distant asteroids and Chiron

NASA Technical Reports Server (NTRS)

French, Linda M.; Vilas, Faith; Hartmann, William K.; Tholen, David J.

1989-01-01

Knowledge of the physical properties of distant asteroids (a greater than 3.3 AU) has grown dramatically over the past five years, due to systematic compositional and lighcurve studies. Most of these objects have red, dark surfaces, and their spectra show a reddening in spectral slope with heliocentric distance, implying a change in surface composition. Trojans for which near-opposition phase curve information is available appear to show little or no opposition effect, unlike any other dark solar system objects. The lightcurve amplitudes of Trojan and Hilda asteroids imply significantly more elongated shapes for these groups than for main-belt asteroids of comparable size. These recent observations are reviewed in the context of their implications for the formationan and subsequent evolution of the distant asteroids, and their interrelations with the main belt, Chiron, and comets.

Thermo-mechanical fatigue behavior of reduced activation ferrite/martensite stainless steels

NASA Astrophysics Data System (ADS)

Petersen, C.; Rodrian, D.

2002-12-01

The thermo-mechanical cycling fatigue (TMCF) behavior of reduced activation ferrite/martensite stainless steels is examined. The test rig consists of a stiff load frame, which is directly heated by the digitally controlled ohmic heating device. Cylindrical specimens are used with a wall thickness of 0.4 mm. Variable strain rates are applied at TMCF test mode, due to the constant heating rate of 5.8 K/s and variable temperature changes. TMCF results of as received EUROFER 97 in the temperature range between 100 and 500-600 °C show a reduction in life time (a factor of 2) compared to F82H mod. and OPTIFER IV. TMCF-experiments with hold times of 100 and 1000 s show dramatic reduction in life time for all three materials.

Prediction of Reduction Potentials of Copper Proteins with Continuum Electrostatics and Density Functional Theory

PubMed Central

Fowler, Nicholas J.; Blanford, Christopher F.

2017-01-01

Abstract Blue copper proteins, such as azurin, show dramatic changes in Cu2+/Cu+ reduction potential upon mutation over the full physiological range. Hence, they have important functions in electron transfer and oxidation chemistry and have applications in industrial biotechnology. The details of what determines these reduction potential changes upon mutation are still unclear. Moreover, it has been difficult to model and predict the reduction potential of azurin mutants and currently no unique procedure or workflow pattern exists. Furthermore, high‐level computational methods can be accurate but are too time consuming for practical use. In this work, a novel approach for calculating reduction potentials of azurin mutants is shown, based on a combination of continuum electrostatics, density functional theory and empirical hydrophobicity factors. Our method accurately reproduces experimental reduction potential changes of 30 mutants with respect to wildtype within experimental error and highlights the factors contributing to the reduction potential change. Finally, reduction potentials are predicted for a series of 124 new mutants that have not yet been investigated experimentally. Several mutants are identified that are located well over 10 Å from the copper center that change the reduction potential by more than 85 mV. The work shows that secondary coordination sphere mutations mostly lead to long‐range electrostatic changes and hence can be modeled accurately with continuum electrostatics. PMID:28815759

Transformation of social networks in the late pre-Hispanic US Southwest.

PubMed

Mills, Barbara J; Clark, Jeffery J; Peeples, Matthew A; Haas, W R; Roberts, John M; Hill, J Brett; Huntley, Deborah L; Borck, Lewis; Breiger, Ronald L; Clauset, Aaron; Shackley, M Steven

2013-04-09

The late pre-Hispanic period in the US Southwest (A.D. 1200-1450) was characterized by large-scale demographic changes, including long-distance migration and population aggregation. To reconstruct how these processes reshaped social networks, we compiled a comprehensive artifact database from major sites dating to this interval in the western Southwest. We combine social network analysis with geographic information systems approaches to reconstruct network dynamics over 250 y. We show how social networks were transformed across the region at previously undocumented spatial, temporal, and social scales. Using well-dated decorated ceramics, we track changes in network topology at 50-y intervals to show a dramatic shift in network density and settlement centrality from the northern to the southern Southwest after A.D. 1300. Both obsidian sourcing and ceramic data demonstrate that long-distance network relationships also shifted from north to south after migration. Surprisingly, social distance does not always correlate with spatial distance because of the presence of network relationships spanning long geographic distances. Our research shows how a large network in the southern Southwest grew and then collapsed, whereas networks became more fragmented in the northern Southwest but persisted. The study also illustrates how formal social network analysis may be applied to large-scale databases of material culture to illustrate multigenerational changes in network structure.

Transformation of social networks in the late pre-Hispanic US Southwest

PubMed Central

Mills, Barbara J.; Clark, Jeffery J.; Peeples, Matthew A.; Haas, W. R.; Roberts, John M.; Hill, J. Brett; Huntley, Deborah L.; Borck, Lewis; Breiger, Ronald L.; Clauset, Aaron; Shackley, M. Steven

2013-01-01

The late pre-Hispanic period in the US Southwest (A.D. 1200–1450) was characterized by large-scale demographic changes, including long-distance migration and population aggregation. To reconstruct how these processes reshaped social networks, we compiled a comprehensive artifact database from major sites dating to this interval in the western Southwest. We combine social network analysis with geographic information systems approaches to reconstruct network dynamics over 250 y. We show how social networks were transformed across the region at previously undocumented spatial, temporal, and social scales. Using well-dated decorated ceramics, we track changes in network topology at 50-y intervals to show a dramatic shift in network density and settlement centrality from the northern to the southern Southwest after A.D. 1300. Both obsidian sourcing and ceramic data demonstrate that long-distance network relationships also shifted from north to south after migration. Surprisingly, social distance does not always correlate with spatial distance because of the presence of network relationships spanning long geographic distances. Our research shows how a large network in the southern Southwest grew and then collapsed, whereas networks became more fragmented in the northern Southwest but persisted. The study also illustrates how formal social network analysis may be applied to large-scale databases of material culture to illustrate multigenerational changes in network structure. PMID:23530201

Emerging forests on abandoned land: Puerto Rico’s new forests

Treesearch

Ariel E. Lugo; Eileen Helmer

2004-01-01

The species composition of forests change continuously as the earth’s biota evolves and adjusts to environmental change. Humans are accelerating the rate of species turnover by moving species around the planet and dramatically changing environmental conditions. Our focus is on new forests in Puerto Rico that emerge naturally on abandoned lands previously converted to...

Ecological lessons from an island that has experienced it all

Treesearch

Ariel E. Lugo

2006-01-01

Puerto Rico has gone through significant land cover change, going from an island that was forested to one that was agrarian and then finally becoming an urban island. Coastal wetlands experienced dramatic changes as alterations occurred in land cover and an eco-systematic analysis of these changes leads to the proposal of the following five ecological lessons learned...

Management curriculum redesign: integrating customer expectations for new leaders.

PubMed

Young, Judith; Urden, Linda D; Wellman, Debra S; Stoten, Sharon

2004-01-01

Tumultuous and dynamic changes in the healthcare environment have resulted in unprecedented stresses and challenges for both nursing education and nursing practice. It is essential that nursing education curricula reflect the rapidly changing technologies and dramatically expanding knowledge and changes in the practice environment and incorporate theory, science, professional standards, and consumer/service input. The authors describe a redesigned undergraduate management curriculum.

Sagebrush steppe and pinyon-juniper ecosystems: effects of changing fire regimes, increased fuel loads, and invasive species

Treesearch

Jeanne C. Chambers; E. Durant McArthur; Steven B. Monson; Susan E. Meyer; Nancy L. Shaw; Robin J. Tausch; Robert R. Blank; Steve Bunting; Richard R. Miller; Mike Pellant; Bruce A. Roundy; Scott C. Walker; Alison Whittaker

2005-01-01

Pinyon-juniper woodlands and Wyoming big sagebrush ecosystems have undergone major changes in vegetation structure and composition since settlement by European Americans. These changes are resulting in dramatic shifts in fire frequency, size and severity. Effective management of these systems has been hindered by lack of information on: (1) presettlement fire regimes...

Navigating to the Future: Understanding Common Tasks in a Multi-Campus Environment in the Dramatically Changing Acquisition World

ERIC Educational Resources Information Center

Bock, Julia; Burgos-Mira, Rosemary

2010-01-01

In the context of a diverse, multi-campus university, this study discusses historical factors and recent changes in scholarly communication and the economic impact of these changes as we seek to forge stronger cooperation among our campuses. After consulting literature, the authors found that issues relating to acquisitions of multi-campus…

Understanding Landscape Change in Open Space Neighborhoods: Views from Developers and Residents

Treesearch

Christine A. Vogt; Robert W. Marans

2002-01-01

The landscape is changing across the country, particularly in outlying areas of US cities. These fringe areas, often called exurbia, continue to move further from the city core. Their growth is largely created by new residential, commercial ,and industrial development. Dramatic land use and land cover changes in these areas from agricultural or forested to buildings...

Understanding landscape change in open space neighborhoods: views from developers and residents

Treesearch

Christine A. Vogt; Robert W. Marans

2003-01-01

The landscape is changing across the country, particularly in outlying areas of US cities. These fringe areas, often called exurbia, continue to move further from the city core. Their growth is largely created by new residential, commercial, and industrial development. Dramatic land use and land cover changes in these areas from agricultural or forested to buildings...

A Stakeholder View of Organizational Adaptation to Technological Change: The Case of U. S. State Universities, 2003-2012

ERIC Educational Resources Information Center

Gould, Robert W.

2013-01-01

This study addressed technological change in the core processes of teaching and learning in U. S. state universities in the decade from 2003-2012. Institutions of higher education in the U. S. have faced dramatically complex and rapidly changing operating environments. In response to these conditions, institutions of higher education have…

The Maker Movement, the Promise of Higher Education, and the Future of Work

ERIC Educational Resources Information Center

Wigner, Aubrey

2017-01-01

The 21st century will be the site of numerous changes in education systems in response to a rapidly evolving technological environment where existing skill sets and career structures may cease to exist or, at the very least, change dramatically. Likewise, the nature of work will also change to become more automated and more technologically…

Pubertal Development and Behavior: Hormonal Activation of Social and Motivational Tendencies

ERIC Educational Resources Information Center

Forbes, Erika E.; Dahl, Ronald E.

2010-01-01

Adolescence is a time of dramatic changes including rapid physical growth, the onset of sexual maturation, the activation of new drives and motivations, and a wide array of social and affective changes and challenges. This review focuses on behavioral changes in this interval and is organized by the claim that a key set of these adolescent changes…

Emission of discrete vortex rings by a vibrating grid in superfluid 3He-B: a precursor to quantum turbulence.

PubMed

Bradley, D I; Clubb, D O; Fisher, S N; Guénault, A M; Haley, R P; Matthews, C J; Pickett, G R; Tsepelin, V; Zaki, K

2005-07-15

We report a transition in the vorticity generated by a grid moving in the B phase of superfluid 3He at T

Cold Reversal on Kodiak Island, Alaska, Correlated with the European Younger Dryas by Using Variations of Atmospheric C-14 Content

NASA Technical Reports Server (NTRS)

Hajdas, Irka; Bonani, Georges; Boden, Per; Peteet, Dorothy M.; Mann, Daniel H.

1999-01-01

High-resolution AMS (accelerator-mass-spectrometer) radiocarbon dating was performed on late-glacial macrofossils in lake sediments from Kodiak Island, Alaska, and on shells in marine sediments from southwest Sweden. In both records, a dramatic drop in radiocarbon ages equivalent to a rise in the atmospheric C-14 by approximately 70%. coincides with the beginning of the cold period at 11000 yr B.P. (C-14 age). Thus our results show that a close correlation between climatic records around the globe is possible by using a global signature of changes in atmospheric C-14 content.

Sensing behavior of a graphene quantum dot phenalenyl towards toxic gases

NASA Astrophysics Data System (ADS)

Sharma, Vaishali; Narayan, Som; Dabhi, Shweta D.; Shinde, Satyam; Jha, Prafulla K.

2018-04-01

In the present work, by studying the interaction of graphene quantum dot (GQD) Phenalenylwith toxic gases hydrogen cyanide (HCN) and phosgene (COCl2) using density functional theory, we are aiming to evaluate the possibility of using GQD phenalenyl in the detection of HCN and COCl2. Owing to strong interactions between HCN/COCl2 and the GQD Phenalenyl, dramatic changes in the electronic properties of the graphene quantum dots together with highest occupied molecular orbitals and lowest unoccupied molecularorbitals (HOMO-LUMO) gap variationsare observed. The findings show that the GQD phenalenyl can be used as chemical nanosensor to detect HCN and COCl2 toxic gases.

On business cycles synchronization in Europe: A note on network analysis

NASA Astrophysics Data System (ADS)

Matesanz, David; Ortega, Guillermo J.

2016-11-01

In this paper we examine synchronization in European business cycles from 1950 to 2013. Herein we further investigate previous and controversial results that arise from complex network analysis of this topic. By focusing on the importance of different configurations in the commonly used rolling windows and threshold significance levels, we find that selections are critical to obtaining accurate networks. Output co-movement and connectivity show no appreciable changes during the beginning of the Euro period, but rather dramatic jumps are observed since the outbreak of the global financial crisis. At this time, previous lead/lag effects disappeared and in-phase synchronization across Europe was observed.

Constructing financial network based on PMFG and threshold method

NASA Astrophysics Data System (ADS)

Nie, Chun-Xiao; Song, Fu-Tie

2018-04-01

Based on planar maximally filtered graph (PMFG) and threshold method, we introduced a correlation-based network named PMFG-based threshold network (PTN). We studied the community structure of PTN and applied ISOMAP algorithm to represent PTN in low-dimensional Euclidean space. The results show that the community corresponds well to the cluster in the Euclidean space. Further, we studied the dynamics of the community structure and constructed the normalized mutual information (NMI) matrix. Based on the real data in the market, we found that the volatility of the market can lead to dramatic changes in the community structure, and the structure is more stable during the financial crisis.

[Web of Science production quality indicators of ten professors' at the area of personality, assessment and psychological treatment: additional contributions to Olivas-Ávila y Musi-Lechuga study].

PubMed

Aluja, Antón; Becoña, Elisardo; Botella, Cristina; Colom, Roberto; Echeburúa, Enrique; Forns, María; Pérez, Miguel; Vila, Jaime

2011-04-01

Rankings of scientific productivity are increasingly relevant both from an individual and a collective perspective. Therefore, making sure they are based on reliable and exhaustive information is really important. This study clearly shows that available rankings change dramatically when internationally acknowledged bibliometric indices are considered. Data from the 10 Professors belonging to the 'Personality, Assessment, and Psychological Treatment' Department considered in the recent analysis by Olivas-Ávila y Musi-Lechuga ( Psicothema 2010. Vol. 22, nº 4, pp. 909-916) are revisited here for illustrative purposes.

National Health Expenditures, 1993

PubMed Central

Levit, Katharine R.; Sensenig, Arthur L.; Cowan, Cathy A.; Lazenby, Helen C.; McDonnell, Patricia A.; Won, Darleen K.; Sivarajan, Lekha; Stiller, Jean M.; Donham, Carolyn S.; Stewart, Madie S.

1994-01-01

This article presents data on health care spending for the United States, covering expenditures for various types of medical services and products and their sources of funding from 1960 to 1993. Although these statistics show a slowing in the growth of health care expenditures over the past few years, spending continues to increase faster than the overall economy. The share of the Nation's health care bill funded by the Federal Government through the Medicaid and Medicare programs steadily increased from 1991 to 1993. This significant change in the share of health expenditures funded by the public sector has caused Federal health expenditures as a share of all Federal spending to increase dramatically. PMID:10140156

Do endothelial cells dream of eclectic shape?

PubMed

Bentley, Katie; Philippides, Andrew; Ravasz Regan, Erzsébet

2014-04-28

Endothelial cells (ECs) exhibit dramatic plasticity of form at the single- and collective-cell level during new vessel growth, adult vascular homeostasis, and pathology. Understanding how, when, and why individual ECs coordinate decisions to change shape, in relation to the myriad of dynamic environmental signals, is key to understanding normal and pathological blood vessel behavior. However, this is a complex spatial and temporal problem. In this review we show that the multidisciplinary field of Adaptive Systems offers a refreshing perspective, common biological language, and straightforward toolkit that cell biologists can use to untangle the complexity of dynamic, morphogenetic systems. Copyright © 2014 Elsevier Inc. All rights reserved.

The effects of changing land cover on streamflow simulation in Puerto Rico

USGS Publications Warehouse

Van Beusekom, Ashley E.; Hay, Lauren E.; Viger, Roland; Gould, William A.; Collazo, Jaime; Henareh Khalyani, Azad

2014-01-01

This study quantitatively explores whether land cover changes have a substantive impact on simulated streamflow within the tropical island setting of Puerto Rico. The Precipitation Runoff Modeling System (PRMS) was used to compare streamflow simulations based on five static parameterizations of land cover with those based on dynamically varying parameters derived from four land cover scenes for the period 1953-2012. The PRMS simulations based on static land cover illustrated consistent differences in simulated streamflow across the island. It was determined that the scale of the analysis makes a difference: large regions with localized areas that have undergone dramatic land cover change may show negligible difference in total streamflow, but streamflow simulations using dynamic land cover parameters for a highly altered subwatershed clearly demonstrate the effects of changing land cover on simulated streamflow. Incorporating dynamic parameterization in these highly altered watersheds can reduce the predictive uncertainty in simulations of streamflow using PRMS. Hydrologic models that do not consider the projected changes in land cover may be inadequate for water resource management planning for future conditions.

Heat Transport Compensation in Atmosphere and Ocean over the Past 22,000 Years

PubMed Central

Yang, Haijun; Zhao, Yingying; Liu, Zhengyu; Li, Qing; He, Feng; Zhang, Qiong

2015-01-01

The Earth’s climate has experienced dramatic changes over the past 22,000 years; however, the total meridional heat transport (MHT) of the climate system remains stable. A 22,000-year-long simulation using an ocean-atmosphere coupled model shows that the changes in atmosphere and ocean MHT are significant but tend to be out of phase in most regions, mitigating the total MHT change, which helps to maintain the stability of the Earth’s overall climate. A simple conceptual model is used to understand the compensation mechanism. The simple model can reproduce qualitatively the evolution and compensation features of the MHT over the past 22,000 years. We find that the global energy conservation requires the compensation changes in the atmosphere and ocean heat transports. The degree of compensation is mainly determined by the local climate feedback between surface temperature and net radiation flux at the top of the atmosphere. This study suggests that an internal mechanism may exist in the climate system, which might have played a role in constraining the global climate change over the past 22,000 years. PMID:26567710

Systemic alterations and their oral manifestations in pregnant women.

PubMed

Silva de Araujo Figueiredo, Camilla; Gonçalves Carvalho Rosalem, Cíntia; Costa Cantanhede, Andre Luis; Abreu Fonseca Thomaz, Érika Bárbara; Fontoura Nogueira da Cruz, Maria Carmen

2017-01-01

The aims of this literature review are: to depict the main oral diseases that are related to pregnancy; to clarify some of the possible systemic mechanisms that are associated with these changes; and to address issues about oral care during pregnancy. A woman's organs undergo various physiological, neurological, and hormonal changes during pregnancy. Such changes occur gradually and are essential for the development of the fetus, providing what is needed for tissue formation and establishment of reserves for uterine and fetal life. In turn, the oral cavity shows some events during this period. Among the changes most frequently cited in the literature are pyogenic granuloma, gingivitis, and periodontitis. The inflammation of the periodontal tissues due to the formation of the biofilm increases dramatically in size and severity during the course of a normal pregnancy, even without changes in the amount of biofilm present. In addition, a decrease in salivary pH is observed in pregnant women and may lead to an increased incidence of dental caries in this period. © 2017 Japan Society of Obstetrics and Gynecology.

Application of 23Na MRI to Monitor Chemotherapeutic Response in RIF-1 Tumors1

PubMed Central

Babsky, Andriy M; Hekmatyar, Shahryar K; Zhang, Hong; Solomon, James L; Bansal, Navin

2005-01-01

Abstract Effects of an alkylating anticancer drug, cyclophosphamide (Cp), on 23Na signal intensity (23Na SI) and water apparent diffusion coefficient (ADC) were examined in subcutaneously-implanted radiation-induced fibrosarcoma (RIF-1) tumors by in vivo 23Na and 1H magnetic resonance imaging (MRI). MRI experiments were performed on untreated control (n = 5) and Cp-treated (n = 6) C3H mice, once before Cp injection (300 mg/kg) then daily for 3 days after treatment. Tumor volumes were significantly lower in treated animals 2 and 3 days posttreatment. At the same time points, MRI experiments showed an increase in both 23Na SI and water ADC in treated tumors, whereas control tumors did not show any significant changes. The correlation between 23Na SI and water ADC changes was dramatically increased in the Cp-treated group, suggesting that the observed increases in 23Na SI and water ADC were caused by the same mechanism. Histologic sections showed decreased cell density in the regions of increased 23Na and water ADC SI. Destructive chemical analysis showed that Cp treatment increased the relative extracellular space and tumor [Na+]. We conclude that the changes in water ADC and 23Na SI were largely due to an increase in extracellular space. 23Na MRI and 1H water ADC measurements may provide valuable noninvasive techniques for monitoring chemotherapeutic responses. PMID:16026645

Hydrogen Balmer alpha intensity distributions and line profiles from multiple scattering theory using realistic geocoronal models

NASA Technical Reports Server (NTRS)

Anderson, D. E., Jr.; Meier, R. R.; Hodges, R. R., Jr.; Tinsley, B. A.

1987-01-01

The H Balmer alpha nightglow is investigated by using Monte Carlo models of asymmetric geocoronal atomic hydrogen distributions as input to a radiative transfer model of solar Lyman-beta radiation in the thermosphere and atmosphere. It is shown that it is essential to include multiple scattering of Lyman-beta radiation in the interpretation of Balmer alpha airglow data. Observations of diurnal variation in the Balmer alpha airglow showing slightly greater intensities in the morning relative to evening are consistent with theory. No evidence is found for anything other than a single sinusoidal diurnal variation of exobase density. Dramatic changes in effective temperature derived from the observed Balmer alpha line profiles are expected on the basis of changing illumination conditions in the thermosphere and exosphere as different regions of the sky are scanned.

Magnified Effects of Changes in NIH Research Funding Levels.

PubMed

Larson, Richard C; Ghaffarzadegan, Navid; Diaz, Mauricio Gomez

2012-12-01

What happens within the university-based research enterprise when a federal funding agency abruptly changes research grant funding levels, up or down? We use simple difference equation models to show that an apparently modest increase or decrease in funding levels can have dramatic effects on researchers, graduate students, postdocs, and the overall research enterprise. The amplified effect is due to grants lasting for an extended period, thereby requiring the majority of funds available in one year to pay for grants awarded in previous years. We demonstrate the effect in various ways, using National Institutes of Health data for two situations: the historical doubling of research funding from 1998 to 2003 and the possible effects of "sequestration" in January 2013. We posit human responses to such sharp movements in funding levels and offer suggestions for amelioration.

Sequence-Mandated, Distinct Assembly of Giant Molecules

DOE PAGES

Zhang, Wei; Lu, Xinlin; Mao, Jialin; ...

2017-10-24

Although controlling the primary structure of synthetic polymers is itself a great challenge, the potential of sequence control for tailoring hierarchical structures remains to be exploited, especially in the creation of new and unconventional phases. A series of model amphiphilic chain-like giant molecules was designed and synthesized by interconnecting both hydrophobic and hydrophilic molecular nanoparticles in precisely defined sequence and composition to investigate their sequence-dependent phase structures. Not only compositional variation changed the self-assembled supramolecular phases, but also specific sequences induce unconventional phase formation, including Frank-Kasper phases. The formation mechanism was attributed to the conformational change driven by the collectivemore » hydrogen bonding and the sequence-mandated topology of the molecules. Lastly, these results show that sequence control in synthetic polymers can have a dramatic impact on polymer properties and self-assembly.« less

Sequence-Mandated, Distinct Assembly of Giant Molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Wei; Lu, Xinlin; Mao, Jialin

Although controlling the primary structure of synthetic polymers is itself a great challenge, the potential of sequence control for tailoring hierarchical structures remains to be exploited, especially in the creation of new and unconventional phases. A series of model amphiphilic chain-like giant molecules was designed and synthesized by interconnecting both hydrophobic and hydrophilic molecular nanoparticles in precisely defined sequence and composition to investigate their sequence-dependent phase structures. Not only compositional variation changed the self-assembled supramolecular phases, but also specific sequences induce unconventional phase formation, including Frank-Kasper phases. The formation mechanism was attributed to the conformational change driven by the collectivemore » hydrogen bonding and the sequence-mandated topology of the molecules. Lastly, these results show that sequence control in synthetic polymers can have a dramatic impact on polymer properties and self-assembly.« less

Magnified Effects of Changes in NIH Research Funding Levels

PubMed Central

Larson, Richard C.; Ghaffarzadegan, Navid; Diaz, Mauricio Gomez

2013-01-01

What happens within the university-based research enterprise when a federal funding agency abruptly changes research grant funding levels, up or down? We use simple difference equation models to show that an apparently modest increase or decrease in funding levels can have dramatic effects on researchers, graduate students, postdocs, and the overall research enterprise. The amplified effect is due to grants lasting for an extended period, thereby requiring the majority of funds available in one year to pay for grants awarded in previous years. We demonstrate the effect in various ways, using National Institutes of Health data for two situations: the historical doubling of research funding from 1998 to 2003 and the possible effects of “sequestration” in January 2013. We posit human responses to such sharp movements in funding levels and offer suggestions for amelioration. PMID:24489978

Influence of snow cover changes on surface radiation and heat balance based on the WRF model

NASA Astrophysics Data System (ADS)

Yu, Lingxue; Liu, Tingxiang; Bu, Kun; Yang, Jiuchun; Chang, Liping; Zhang, Shuwen

2017-10-01

The snow cover extent in mid-high latitude areas of the Northern Hemisphere has significantly declined corresponding to the global warming, especially since the 1970s. Snow-climate feedbacks play a critical role in regulating the global radiation balance and influencing surface heat flux exchange. However, the degree to which snow cover changes affect the radiation budget and energy balance on a regional scale and the difference between snow-climate and land use/cover change (LUCC)-climate feedbacks have been rarely studied. In this paper, we selected Heilongjiang Basin, where the snow cover has changed obviously, as our study area and used the WRF model to simulate the influences of snow cover changes on the surface radiation budget and heat balance. In the scenario simulation, the localized surface parameter data improved the accuracy by 10 % compared with the control group. The spatial and temporal analysis of the surface variables showed that the net surface radiation, sensible heat flux, Bowen ratio, temperature and percentage of snow cover were negatively correlated and that the ground heat flux and latent heat flux were positively correlated with the percentage of snow cover. The spatial analysis also showed that a significant relationship existed between the surface variables and land cover types, which was not obviously as that for snow cover changes. Finally, six typical study areas were selected to quantitatively analyse the influence of land cover types beneath the snow cover on heat absorption and transfer, which showed that when the land was snow covered, the conversion of forest to farmland can dramatically influence the net radiation and other surface variables, whereas the snow-free land showed significantly reduced influence. Furthermore, compared with typical land cover changes, e.g., the conversion of forest into farmland, the influence of snow cover changes on net radiation and sensible heat flux were 60 % higher than that of land cover changes, indicating the importance of snow cover changes in the surface-atmospheric feedback system.

Spin-Down of the North Atlantic Subpolar Circulation

NASA Technical Reports Server (NTRS)

Hakkinen, S.; Rhines, P. B.

2004-01-01

Dramatic changes have occurred in the mid-to-high-latitude North Atlantic Ocean as evidenced by TOPEX/Poseidon observations of sea surface height (SSH) in the subpolar gyre and the Gulf Stream. Analysis of altimeter data shows that subpolar SSH has increased during the 1990s and the geostrophic velocity derived from altimeter data shows a decline in the gyre circulation. Direct current-meter observations in the boundary current of the Labrador Sea support the trend in the 199Os, and, together with hydrographic data show that in the mid-late 1990s the trend extends deep in the water column. We find that buoyancy forcing over the northern North Atlantic has a dynamic effect consistent with the altimeter data and hydrographic observations: a weak thermohaline forcing and the subsequent decay of the domed structure of the subpolar isopycnals would give rise to the observed anticyclonic circulation trend.

Automated Techniques for Quantification of Coastline Change Rates using Landsat Imagery along Caofeidian, China

NASA Astrophysics Data System (ADS)

Dong, Di; Li, Ziwei; Liu, Zhaoqin; Yu, Yang

2014-03-01

This paper focuses on automated extraction and monitoring of coastlines by remote sensing techniques using multi-temporal Landsat imagery along Caofeidian, China. Caofeidian, as one of the active economic regions in China, has experienced dramatic change due to enhanced human activities, such as land reclamation. These processes have caused morphological changes of the Caofeidian shoreline. In this study, shoreline extraction and change analysis are researched. An algorithm based on image texture and mathematical morphology is proposed to automate coastline extraction. We tested this approach and found that it's capable of extracting coastlines from TM and ETM+ images with little human modifications. Then, the detected coastline vectors are imported into Arcgis software, and the Digital Shoreline Analysis System (DSAS) is used to calculate the change rate (the end point rate and linear regression rate). The results show that in some parts of the research area, remarkable coastline changes are observed, especially the accretion rate. The abnormal accretion is mostly attributed to the large-scale land reclamation during 2003 and 2004 in Caofeidian. So we can conclude that various construction projects, especially the land reclamation project, have made Caofeidian shorelines change greatly, far above the normal.

Analysis of Future Streamflow Regimes under Global Change Scenarios in Central Chile for Ecosystem Sustainability

NASA Astrophysics Data System (ADS)

Henriquez Dole, L. E.; Gironas, J. A.; Vicuna, S.

2015-12-01

Given the critical role of the streamflow regime for ecosystem sustainability, modeling long term effects of climate change and land use change on streamflow is important to predict possible impacts in stream ecosystems. Because flow duration curves are largely used to characterize the streamflow regime and define indices of ecosystem health, they were used to represent and analyze in this study the stream regime in the Maipo River Basin in Central Chile. Water and Environmental Assessment and Planning (WEAP) model and the Plant Growth Model (PGM) were used to simulate water distribution, consumption in rural areas and stream flows on a weekly basis. Historical data (1990-2014), future land use scenarios (2030/2050) and climate change scenarios were included in the process. Historical data show a declining trend in flows mainly by unprecedented climatic conditions, increasing interest among users on future streamflow scenarios. In the future, under an expected decline in water availability coupled with changes in crop water demand, water users will be forced to adapt by changing water allocation rules. Such adaptation actions would in turns affect the streamflow regime. Future scenarios for streamflow regime show dramatic changes in water availability and temporal distribution. Annual weekly mean flows can reduce in 19% in the worst scenario and increase in 3.3% in the best of them, and variability in streamflow increases nearly 90% in all scenarios under evaluation. The occurrence of maximum and minimum monthly flows changes, as June instead of July becomes the driest month, and December instead of January becomes the month with maximum flows. Overall, results show that under future scenarios streamflow is affected and altered by water allocation rules to satisfy water demands, and thus decisions will need to consider the streamflow regime (and habitat) in order to be sustainable.

HIF-1 and SKN-1 coordinate the transcriptional response to hydrogen sulfide in Caenorhabditis elegans.

PubMed

Miller, Dana L; Budde, Mark W; Roth, Mark B

2011-01-01

Hydrogen sulfide (H₂S) has dramatic physiological effects on animals that are associated with improved survival. C. elegans grown in H₂S are long-lived and thermotolerant. To identify mechanisms by which adaptation to H₂S effects physiological functions, we have measured transcriptional responses to H₂S exposure. Using microarray analysis we observe rapid changes in the abundance of specific mRNAs. The number and magnitude of transcriptional changes increased with the duration of H₂S exposure. Functional annotation suggests that genes associated with protein homeostasis are upregulated upon prolonged exposure to H₂S. Previous work has shown that the hypoxia-inducible transcription factor, HIF-1, is required for survival in H₂S. In fact, we show that hif-1 is required for most, if not all, early transcriptional changes in H₂S. Moreover, our data demonstrate that SKN-1, the C. elegans homologue of NRF2, also contributes to H₂S-dependent changes in transcription. We show that these results are functionally important, as skn-1 is essential to survive exposure to H₂S. Our results suggest a model in which HIF-1 and SKN-1 coordinate a broad transcriptional response to H₂S that culminates in a global reorganization of protein homeostasis networks.

Opsin co-expression in Limulus photoreceptors: differential regulation by light and a circadian clock

PubMed Central

Katti, C.; Kempler, K.; Porter, M. L.; Legg, A.; Gonzalez, R.; Garcia-Rivera, E.; Dugger, D.; Battelle, B.-A.

2010-01-01

A long-standing concept in vision science has held that a single photoreceptor expresses a single type of opsin, the protein component of visual pigment. However, the number of examples in the literature of photoreceptors from vertebrates and invertebrates that break this rule is increasing. Here, we describe a newly discovered Limulus opsin, Limulus opsin5, which is significantly different from previously characterized Limulus opsins, opsins1 and 2. We show that opsin5 is co-expressed with opsins1 and 2 in Limulus lateral and ventral eye photoreceptors and provide the first evidence that the expression of co-expressed opsins can be differentially regulated. We show that the relative levels of opsin5 and opsin1 and 2 in the rhabdom change with a diurnal rhythm and that their relative levels are also influenced by the animal's central circadian clock. An analysis of the sequence of opsin5 suggests it is sensitive to visible light (400–700 nm) but that its spectral properties may be different from that of opsins1 and 2. Changes in the relative levels of these opsins may underlie some of the dramatic day–night changes in Limulus photoreceptor function and may produce a diurnal change in their spectral sensitivity. PMID:20639420

Urban Spatial Ecological Performance Based on the Data of Remote Sensing of Guyuan

NASA Astrophysics Data System (ADS)

Ren, X.-J.; Chen, X.-J.; Ma, Q.

2018-04-01

The evolution analysis of urban landuse and spatial ecological performance are necessary and useful to recognizing the stage of urban development and revealing the regularity and connotation of urban spatial expansion. Moreover, it lies in the core that should be exmined in the urban sustainable development. In this paper, detailed information has been acquired from the high-resolution satellite imageries of Guyuan, China case study. With the support of GIS, the land-use mapping information and the land cover changes are analyzed, and the process of urban spatial ecological performance evolution by the hierarchical methodology is explored. Results demonstrate that in the past 11 years, the urban spatial ecological performance show an improved process with the dramatic landcover change in Guyuan. Firstly, the landuse structure of Guyuan changes significantly and shows an obvious stage characteristic. Secondly, the urban ecological performance of Guyuan continues to be optimized over the 11 years. Thirdly, the findings suggest that a dynamic monitoring mechanism of urban land use based on high-resolution remote sensing data should be established in urban development, and the rational development of urban land use should be guided by the spatial ecological performance as the basic value orientation.

Self body-size perception in an insect

NASA Astrophysics Data System (ADS)

Ben-Nun, Amir; Guershon, Moshe; Ayali, Amir

2013-05-01

Animals negotiating complex environments encounter a wide range of obstacles of different shapes and sizes. It is greatly beneficial for the animal to react to such obstacles in a precise, context-specific manner, in order to avoid harm or even simply to minimize energy expenditure. An essential key challenge is, therefore, an estimation of the animal's own physical characteristics, such as body size. A further important aspect of self body-size perception (or SBSP) is the need to update it in accordance with changes in the animal's size and proportions. Despite the major role of SBSP in functional behavior, little is known about if and how it is mediated. Here, we demonstrate that insects are also capable of self perception of body size and that this is a vital factor in allowing them to adjust their behavior following the sudden and dramatic growth associated with periodic molting. We reveal that locusts' SBSP is strongly correlated with their body size. However, we show that the dramatic change in size accompanying adult emergence is not sufficient to create a new and updated SBSP. Rather, this is created and then consolidated only following the individuals' experience and interaction with the physical environment. Behavioral or pharmacological manipulations can both result in maintenance of the old larval SBSP. Our results emphasize the importance of learning and memory-related processes in the development and update of SBSP, and highlight the advantage of insects as good models for a detailed study on the neurobiological and molecular aspects of SBSP.

Immunological changes following protein losing enteropathy after surgery total cavopulmonary connection (TCPC) by cytomics

NASA Astrophysics Data System (ADS)

Bocsi, József; Lenz, Dominik; Mittag, Anja; Sauer, Ursula; Wild, Lena; Hess, John; Schranz, Dietmar; Hambsch, Jörg; Schneider, Peter; Tárnok, Attila

2008-02-01

Complex immunophenotyping single-cell analysis are essential for systems biology and cytomics. The application of cytomics in immunology and cardiac research and diagnostics is very broad, ranging from the better understanding of the cardiovascular cell biology to the identification of heart function and immune consequences after surgery. TCPC or Fontan-type circulation is an accepted palliative surgery for patients with a functionally univentricular heart. Protein-losing enteropathy (PLE), the enteric loss of proteins, is a potential late complication after TCPC surgery. PLE etiology is poorly understood, but immunological factors seem to play a role. This study was aimed to gain insight into immune phenotype alterations following post-TCPC PLE. Patients were studied during routine follow-up up to 5yrs after surgery, blood samples of TCPC patients without (n=21, age 6.8+/-2.6 years at surgery; mean+/-SD) and with manifest PLE (n=12, age 12.8+/- 4.5 years at sampling) and age matched healthy children (control, n=22, age 8.6+/-2.5 years) were collected. Routine laboratory, immune phenotype and serological parameters were determined. Following PLE the immune phenotype dramatically changed with signs of acute inflammation (increased neutrophil and monocyte count, CRP, IL-8). In contrast, lymphocyte count (NK-cells, αβTCR +CD4 +, αβTCR +CD8 + cells) decreased (p<0.001). The residual T-cells had elevated CD25 and CD69 expression. In PLE-patients unique cell populations with CD3 +αβ/γδTCR - and αβTCR +CD4 -8 - phenotype were present in increased frequencies. Our studies show dramatically altered leukocyte phenotype after PLE in TCPC patients. These alterations resemble to changes in autoimmune diseases. We conclude that autoimmune processes may play a role in etiology and pathophysiology of PLE.

Evidence of Repeated and Independent Saltational Evolution in a Peculiar Genus of Sphinx Moths (Proserpinus: Sphingidae)

PubMed Central

Rubinoff, Daniel; Le Roux, Johannes J.

2008-01-01

Background Saltational evolution in which a particular lineage undergoes relatively rapid, significant, and unparalleled change as compared with its closest relatives is rarely invoked as an alternative model to the dominant paradigm of gradualistic evolution. Identifying saltational events is an important first-step in assessing the importance of this discontinuous model in generating evolutionary novelty. We offer evidence for three independent instances of saltational evolution in a charismatic moth genus with only eight species. Methodology/Principal Findings Maximum parsimony, maximum likelihood and Bayesian search criteria offered congruent, well supported phylogenies based on 1,965 base pairs of DNA sequence using the mitochondrial gene cytochrome oxidase subunit I, and the nuclear genes elongation factor-1 alpha and wingless. Using a comparative methods approach, we examined three taxa exhibiting novelty in the form of Batesian mimicry, host plant shift, and dramatic physiological differences in light of the phylogenetic data. All three traits appear to have evolved relatively rapidly and independently in three different species of Proserpinus. Each saltational species exhibits a markedly different and discrete example of discontinuous trait evolution while remaining canalized for other typical traits shared by the rest of the genus. All three saltational taxa show insignificantly different levels of overall genetic change as compared with their congeners, implying that their divergence is targeted to particular traits and not genome-wide. Conclusions/Significance Such rapid evolution of novel traits in individual species suggests that the pace of evolution can be quick, dramatic, and isolated—even on the species level. These results may be applicable to other groups in which specific taxa have generated pronounced evolutionary novelty. Genetic mechanisms and methods for assessing such relatively rapid changes are postulated. PMID:19107205

Evidence of repeated and independent saltational evolution in a peculiar genus of sphinx moths (Proserpinus: Sphingidae).

PubMed

Rubinoff, Daniel; Le Roux, Johannes J

2008-01-01

Saltational evolution in which a particular lineage undergoes relatively rapid, significant, and unparalleled change as compared with its closest relatives is rarely invoked as an alternative model to the dominant paradigm of gradualistic evolution. Identifying saltational events is an important first-step in assessing the importance of this discontinuous model in generating evolutionary novelty. We offer evidence for three independent instances of saltational evolution in a charismatic moth genus with only eight species. Maximum parsimony, maximum likelihood and Bayesian search criteria offered congruent, well supported phylogenies based on 1,965 base pairs of DNA sequence using the mitochondrial gene cytochrome oxidase subunit I, and the nuclear genes elongation factor-1 alpha and wingless. Using a comparative methods approach, we examined three taxa exhibiting novelty in the form of Batesian mimicry, host plant shift, and dramatic physiological differences in light of the phylogenetic data. All three traits appear to have evolved relatively rapidly and independently in three different species of Proserpinus. Each saltational species exhibits a markedly different and discrete example of discontinuous trait evolution while remaining canalized for other typical traits shared by the rest of the genus. All three saltational taxa show insignificantly different levels of overall genetic change as compared with their congeners, implying that their divergence is targeted to particular traits and not genome-wide. Such rapid evolution of novel traits in individual species suggests that the pace of evolution can be quick, dramatic, and isolated--even on the species level. These results may be applicable to other groups in which specific taxa have generated pronounced evolutionary novelty. Genetic mechanisms and methods for assessing such relatively rapid changes are postulated.

Toward Developmental Connectomics of the Human Brain

PubMed Central

Cao, Miao; Huang, Hao; Peng, Yun; Dong, Qi; He, Yong

2016-01-01

Imaging connectomics based on graph theory has become an effective and unique methodological framework for studying structural and functional connectivity patterns of the developing brain. Normal brain development is characterized by continuous and significant network evolution throughout infancy, childhood, and adolescence, following specific maturational patterns. Disruption of these normal changes is associated with neuropsychiatric developmental disorders, such as autism spectrum disorders or attention-deficit hyperactivity disorder. In this review, we focused on the recent progresses regarding typical and atypical development of human brain networks from birth to early adulthood, using a connectomic approach. Specifically, by the time of birth, structural networks already exhibit adult-like organization, with global efficient small-world and modular structures, as well as hub regions and rich-clubs acting as communication backbones. During development, the structure networks are fine-tuned, with increased global integration and robustness and decreased local segregation, as well as the strengthening of the hubs. In parallel, functional networks undergo more dramatic changes during maturation, with both increased integration and segregation during development, as brain hubs shift from primary regions to high order functioning regions, and the organization of modules transitions from a local anatomical emphasis to a more distributed architecture. These findings suggest that structural networks develop earlier than functional networks; meanwhile functional networks demonstrate more dramatic maturational changes with the evolution of structural networks serving as the anatomical backbone. In this review, we also highlighted topologically disorganized characteristics in structural and functional brain networks in several major developmental neuropsychiatric disorders (e.g., autism spectrum disorders, attention-deficit hyperactivity disorder and developmental dyslexia). Collectively, we showed that delineation of the brain network from a connectomics perspective offers a unique and refreshing view of both normal development and neuropsychiatric disorders. PMID:27064378

Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets.

PubMed

Etulain, Julia; Negrotto, Soledad; Carestia, Agostina; Pozner, Roberto Gabriel; Romaniuk, María Albertina; D'Atri, Lina Paola; Klement, Giannoula Lakka; Schattner, Mirta

2012-01-01

Acidosis is one of the hallmarks of tissue injury such as trauma, infection, inflammation, and tumour growth. Although platelets participate in the pathophysiology of all these processes, the impact of acidosis on platelet biology has not been studied outside of the quality control of laboratory aggregation assays or platelet transfusion optimization. Herein, we evaluate the effect of physiologically relevant changes in extracellular acidosis on the biological function of platelets, placing particular emphasis on haemostatic and secretory functions. Platelet haemostatic responses such as adhesion, spreading, activation of αIIbβ3 integrin, ATP release, aggregation, thromboxane B2 generation, clot retraction and procoagulant activity including phosphatidilserine exposure and microparticle formation, showed a statistically significant inhibition of thrombin-induced changes at pH of 7.0 and 6.5 compared to the physiological pH (7.4). The release of alpha granule content was differentially regulated by acidosis. At low pH, thrombin or collagen-induced secretion of vascular endothelial growth factor and endostatin were dramatically reduced. The release of von Willebrand factor and stromal derived factor-1α followed a similar, albeit less dramatic pattern. In contrast, the induction of CD40L was not changed by low pH, and P-selectin exposure was significantly increased. While the generation of mixed platelet-leukocyte aggregates and the increased chemotaxis of neutrophils mediated by platelets were further augmented under acidic conditions in a P-selectin dependent manner, the increased neutrophil survival was independent of P-selectin expression. In conclusion, our results indicate that extracellular acidosis downregulates most of the haemostatic platelet functions, and promotes those involved in amplifying the neutrophil-mediated inflammatory response.

An analysis of secular trends in method-specific suicides in Japan, 1950-1975.

PubMed

Yoshioka, Eiji; Saijo, Yasuaki; Kawachi, Ichiro

2017-04-05

In Japan, a dramatic rise in suicide rates was observed in the 1950s, especially among the younger population, and then the rate decreased rapidly again in the 1960s. The aim of this study was to assess secular trends in method-specific suicides by gender and age in Japan between 1950 and 1975. We paid special attention to suicides by poisoning (solid and liquid substances), and their contribution to dramatic swings in the overall suicide rate in Japan during the 1950s and 1960s. Mortality and population data were obtained from the Vital Statistics of Japan and Statistics Bureau, Ministry of Internal Affairs and Communications in Japan, respectively. We calculated method-specific age-standardized suicide rates by gender and age group (15-29, 30-49, or 50+ years). The change in the suicide rate during the research period was larger in males than females in all age groups, and was more marked among people aged 15-29 years compared to those aged 30-49 years and 50 years or over. Poisoning by solid and liquid substances overwhelmingly contributed to the dramatic change in the overall suicide rates in males and females aged 15-49 years in the 1950s and 1960s. For the peak years of the rise in poisoning suicides, bromide was the most frequently used substance. Our results for the 1950s and 1960s in Japan illustrated how assessing secular trends in method-specific suicides by gender and age could provide a deeper understanding of the dramatic swings in overall suicide rate. Although rapid increases or decreases in suicide rates have been also observed in some countries or regions recently, trends in method-specific suicides have not been analyzed because of a lack of data on method-specific suicide in many countries. Our study illustrates how the collection and analysis of method-specific data can contribute to an understanding of dramatic shifts in national suicide rates.

Monitoring the Impact of Climate Change on Soil Salinity in Agricultural Areas Using Ground and Satellite Sensors

USDA-ARS?s Scientific Manuscript database

Changes in climatic patterns have had dramatic influence on agricultural areas worldwide, particularly in irrigated arid-zone agricultural areas subjected to recurring drought, such as California’s San Joaquin Valley (SJV), or areas receiving above average rainfall for a decade or more, such as Minn...

Catholic Schools in New Orleans in the Aftermath of Hurricane Katrina

ERIC Educational Resources Information Center

MacGregor, Carol Ann; Fitzpatrick, Brian

2014-01-01

Changes in the education system following Hurricane Katrina have received considerable attention from scholars in recent years. However, the role of Catholic schools is often overlooked in such discussions of school reform, which most often concentrate on the dramatic changes in the public school sector. This oversight is significant given that…

Organizational Change. Symposium 11. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

ERIC Educational Resources Information Center

2000

This packet contains three papers from a symposium on organizational change. The first paper, "Kaizen Blitz: Rapid Learning to Facilitate Immediate Organizational Improvements" (Robert B. Gudgel, Fred C. Feitler), describes rapid and dramatic improvement in the organizational performance of a manufacturing firm after use of a series of…

40 years of hardwood lumber comsumption: 1963 to 2002

Treesearch

William Luppold; Matthew Bumgardner

2008-01-01

An analysis of hardwood lumber consumption found that demand has changed dramatically over the past four decades as a result of material substitution, changes in construction and remodeling products markets, and globalization. In 1963 furniture producers consumed 36 percent of the hardwood products lumber used by domestic manufacturers. Producers of hardwood...

Effects of climate change on forest insect and disease outbreaks

Treesearch

David W. Williams; Robert P. Long; Philip M. Wargo; Andrew M. Liebhold

2000-01-01

General circulation models (GCMs) predict dramatic future changes in climate for the northeastern and north central United States under doubled carbon dioxide (CO2) levels (Hansen et al., 1984; Manabe and Wetherald, 1987; Wilson and Mitchell, 1987; Cubasch and Cess, 1990; Mitchell et al., 1990). January temperatures are projected to rise as much...

Changes in the sensory perception of 'Hass' avocado during fruit maturation and ripening

USDA-ARS?s Scientific Manuscript database

Avocado flavor improves dramatically during maturation and also changes as a result of ripening, but prior research had focused almost entirely on alterations in oil content as a means of explaining the differences in flavor. Other factors beyond just oil content are likely involved that act to alt...

A Case Study in Organizational Change: Evaluation in Cooperative Extension

ERIC Educational Resources Information Center

Rennekamp, Roger A.; Engle, Molly

2008-01-01

This chapter examines how factors both internal and external to Cooperative Extension have influenced its commitment and capability to assess the quality and impact of its programs. The authors begin by documenting how the nature of Extension programming has changed dramatically in response to societal needs over the course of the organization's…

An Analysis of Regional Employment Growth, 1973-85.

ERIC Educational Resources Information Center

Rones, Philip L.

1986-01-01

This article describes some of the changes in regional employment over the past decade or so, with particular emphasis on the industrial components of those changes; then it examines some of the reasons for dramatically uneven regional employment growth, focusing on such aspects as population and business migration, regional income inequality, and…

Academic Work: The Changing Labour Process in Higher Education.

ERIC Educational Resources Information Center

Smyth, John, Ed.

This collection of papers examines what academics do as a work process and how that is changing dramatically with the fiscal crises being experienced by most governments around the world. It explores how academic work is organized, how it is enacted, in whose interests, and with what ultimate effects. Papers include: "Markets in Higher…

Crisis in the Workplace: The Role of the Occupational Social Worker.

ERIC Educational Resources Information Center

Ribner, David S.

1993-01-01

Notes that Israeli economy underwent dramatic and generally negative changes during Gulf War. Examines socioeconomic impact of war and efforts of occupational social workers to cope with needs of Israeli workers. Examines techniques of crisis intervention in context of pervasive atmosphere of change and uncertainty. Concludes with look at…

Twenty-First Century Literacy. Technical Report No. 624.

ERIC Educational Resources Information Center

Bruce, Bertram C.

Important and dramatic changes are occurring in five broad areas of literacy: the movement toward universal literacy; the changing demands for literacy in the workplace; the creation of a global society; how languages are evolving; and the way literacy practices are becoming immersed in new technologies. Future literacy needs will demand a…

Detection of the ubiquitinome in cells undergoing oncogene-induced senescence

PubMed Central

Zhu, Hengrui; Le, Linh; Tang, Hsin-Yao; Speicher, David W.; Zhang, Rugang

2017-01-01

Summary Senescent cells exhibit dramatic changes in protein post-translational modifications. Here, we describe a method, stable isotope labeling with amino acids in cell culture (SILAC) coupled to liquid chromatography tandem mass spectrometry (LC-MS/MS), to identify changes in the ubiquitinome in cells that have undergone oncogene-induced senescence. PMID:27812874

Negotiating for Change: Women's Movements and Education Reform in Taiwan

ERIC Educational Resources Information Center

Lee, Shu-Ching

2011-01-01

The dramatic changes during the past 20 years in Taiwan offer a good example of how gender policy in education is facilitated by a combination of interrelated economic, political and social forces. Taiwan's policy on gender education emerged from the interaction of state, education, academic and non-academic feminist positions in reforms. This…

A view of Antarctic ice-sheet evolution from sea-level and deep-sea Isotope Changes During the Late Cretaceous-Cenozoic

USGS Publications Warehouse

Miller, K.G.; Wright, J.D.; Katz, M.E.; Browning, J.V.; Cramer, B.S.; Wade, B.S.; Mizintseva, S.F.

2007-01-01

18O increase. This large ice sheet became a driver of climate change, not just a response to it, causing increased latitudinal thermal gradients and a spinning up of the oceans that, in turn, caused a dramatic reorganization of ocean circulation and chemistry.

Maintenance of forest ecosystem health and vitality

Treesearch

Ryan D. DeSantis; W. Keith Moser

2016-01-01

Forest health will likely be threatened by a number of factors - including fragmentation, fire regime alteration, and a variety of diseases, insects, and invasive plants - along with global climate change (Krist et al. 2007, Tkacz et al. 2008). By itself, global climate change could dramatically and rapidly alter forest composition and structure (Allen and Breshears...

The Board's Role in Financial Oversight. AGB Board Essentials Series

ERIC Educational Resources Information Center

Krawitz, Natalie

2015-01-01

An often-volatile economy, changing demographics, and technological innovations in educational delivery are among the dramatic changes across higher education that have forced boards and institutions to question the viability of the existing business model. Flat or declining state support in real terms, lower investment returns in some years,…

Seasonal and elevational variation of δ18O and δ2H in the Willamette River basin

EPA Science Inventory

Climate change is expected to dramatically alter the timing and quantity of water within the nation’s river systems. These changes are driven by variation in the form, location and amount of precipitation that will affect the temporal and spatial distribution of river source wat...

Changing Images of the Inclined Plane: A Case Study of a Revolution in American Science Education

ERIC Educational Resources Information Center

Turner, Steven C.

2012-01-01

Between 1880 and 1920 the way science was taught in American High Schools changed dramatically. The old "lecture/demonstration" method, where information was presented to essentially passive students, was replaced by the "laboratory" method, where students performed their own experiments in specially constructed student laboratories. National…

The Proteus Effect: The Effect of Transformed Self-Representation on Behavior

ERIC Educational Resources Information Center

Yee, Nick; Bailenson, Jeremy

2007-01-01

Virtual environments, such as online games and web-based chat rooms, increasingly allow us to alter our digital self-representations dramatically and easily. But as we change our self-representations, do our self-representations change our behavior in turn? In 2 experimental studies, we explore the hypothesis that an individual's behavior conforms…

Climate change induced invasions by native and exotic pests

Treesearch

Jesse A. Logan

2007-01-01

The importance of effective risk assessment for introduction and establishment of exotic pest species has dramatically increased with an expanded global economy and the accompanying increase in international trade. Concurrently, recent climate warming has resulted in potential invasion of new habitats by native pest species. The time frame of response to changing...

Teacher Training through the Regression Model in Foreign Language Education

ERIC Educational Resources Information Center

Garcia Laborda, Jesus

2011-01-01

In the last few years, Spain has seen dramatic changes in its educational system. Many of them have been rejected by most teachers after their implementation (LOGSE) while others have found potential drawbacks even before starting operating (LOCE, LOE). To face these changes, schools need well qualified instructors. Given this need, and also…

Perceived Barriers for First-Generation Students: Reforms to Level the Terrain

ERIC Educational Resources Information Center

Unverferth, Anthony Richard; Talbert-Johnson, Carolyn; Bogard, Treavor

2012-01-01

This article examines the pervasive difficulties experienced by first-generation students in their quest to attend postsecondary settings. A change in the profile of the undergraduate student body has changed dramatically with respect to first-generation students' age, enrollment status, and family conditions. These students are likely to enter…

A Smooth Road from Conventional Teaching to Distance Learning in Teacher Education

ERIC Educational Resources Information Center

Nishinosono, Haruo

2002-01-01

As a result of rapid developments in information and communication technology (ICT), dramatic changes are taking place in approaches to teaching and learning in university and school classrooms. These changes offer new opportunities to explore entirely new methods of instruction in teacher education. ICT provides alternatives to conventional…

Early Bilingualism Enhances Mechanisms of False-Belief Reasoning

ERIC Educational Resources Information Center

Kovacs, Agnes Melinda

2009-01-01

In their first years, children's understanding of mental states seems to improve dramatically, but the mechanisms underlying these changes are still unclear. Such "theory of mind" (ToM) abilities may arise during development, or have an innate basis, developmental changes reflecting limitations of other abilities involved in ToM tasks (e.g.…

Poverty and the American Family: A Decade in Review

ERIC Educational Resources Information Center

Edin, Kathryn; Kissane, Rebecca Joyce

2010-01-01

Because of dramatic levels of economic volatility and massive changes in welfare policies, scholars in this decade worried anew about whether our official poverty measure, adopted in the 1960s, is adequate. Poverty's causes continued to be debated, with demographic factors often pitted against policy and maternal employment changes. Some scholars…

Blended Learning in the Visual Communications Classroom: Student Reflections on a Multimedia Course

ERIC Educational Resources Information Center

George-Palilonis, Jennifer; Filak, Vincent

2009-01-01

Advances in digital technology and a rapidly evolving media landscape continue to dramatically change teaching and learning. Among these changes is the emergence of multimedia teaching and learning tools, online degree programs, and hybrid classes that blend traditional and digital content delivery. At the same time, visual communication programs…

Between a Rock and a Hard Place: Organizational Change and Performance under Conditions of Fundamental Environmental Transformation.

ERIC Educational Resources Information Center

Haveman, Heather A.

1992-01-01

Organizational change may benefit performance and survival chances if it occurs in response to dramatic restructuring of environmental conditions and builds on established routines and competencies. These propositions are tested on the savings and loan industry in California, which has experienced technological, economic, and regulatory shifts…

Recent artificial selection in U.S. Jersey cattle impacts autozygosity levels of specific genomic regions

USDA-ARS?s Scientific Manuscript database

Genome signatures of artificial selection in U.S. Jersey cattle were identified by examining changes in haplotype homozygosity for a resource population of animals born between 1962 and 2005. Genetic merit of this population changed dramatically during this period for a number of traits, especially ...

Cultivating Revolutionary Educational Leaders: Translating Emerging Theories into Action

ERIC Educational Resources Information Center

Kezar, Adrianna; Carducci, Rozana

2007-01-01

In this article, the authors describe the way that leadership research has dramatically changed over the last 30 years and how leadership development programs have not kept pace with some of the important changes. In particular, the authors propose that five revolutionary leadership concepts have been overlooked and should be included in future…

Anatomy Instruction in Medical Schools: Connecting the Past and the Future

ERIC Educational Resources Information Center

Leung, Kai-kuen; Lu, Kuo-Shyan; Huang, Tien-Shang; Hsieh, Bor-Shen

2006-01-01

Anatomy curriculum has changed dramatically around the world since the 1960s. These changes include the reduction of course hours, the abandonment of cadaver dissection, the use of problem-based learning, application of other teaching modalities such as prosected specimens, models, radiographic images, computer simulations, and the introduction of…

Subtle Tortures of the Neo-liberal Age: Teachers, Students, and the Political Economy of Schooling in Chile

ERIC Educational Resources Information Center

Pastrana, Jill Pinkney

2007-01-01

In the late 1970s following a military coup, Chile, with its population brutally suppressed, became the first testing ground for the changes that now define neo-liberal recommendations by international funding agencies such as the IMF and World Bank. The changes were dramatic and extensive. The population could not negotiate the terms of change.…

Political Stereotypes among Students and Instructors in Higher Education: An Analytical Report Based on Materials of a Sociological Survey (November-December 1990).

ERIC Educational Resources Information Center

Iudin, A. A.; And Others

1993-01-01

Asserts that during periods of rapid social change, the political consciousness of the population also changes dramatically. Reports on a survey of 1,800 students and 1,270 instructors in Russian higher education institutions. Finds that changes in social consciousness are not proceeding along lines of rational interpretation of facts and ideas.…

Making a Difference in Research and Practice: A Commentary on "Consulting to Facilitate Planned Organizational Change in Schools," an Article by Joseph E. Zins and Robert J. Illback

ERIC Educational Resources Information Center

Flaspohler, Paul D.

2007-01-01

Zins and Illback observed in 1995 that planned organizational change processes were neglected in practice, training, and research. In the decade following publication of their article, implementation of processes and structures of planned organizational change increased dramatically. Schools and school districts continue to face increased…

Detecting mortality induced structural and functional changes in a pinon-juniper woodland using Landsat and RapidEye time series

Treesearch

Dan J. Krofcheck; Jan U. H. Eitel; Lee A. Vierling; Urs Schulthess; Timothy M. Hilton; Eva Dettweiler-Robinson; Rosemary Pendleton; Marcy E. Litvak

2014-01-01

Pinon-juniper (PJ) woodlands have recently undergone dramatic drought-induced mortality, triggering broad scale structural changes in this extensive Southwestern US biome. Given that climate projections for the region suggest widespread conifer mortality is likely to continue into the next century, it is critical to better understand how this climate-induced change in...

USGS Arctic Science Strategy

USGS Publications Warehouse

Shasby, Mark; Smith, Durelle

2015-07-17

The United States is one of eight Arctic nations responsible for the stewardship of a polar region undergoing dramatic environmental, social, and economic changes. Although warming and cooling cycles have occurred over millennia in the Arctic region, the current warming trend is unlike anything recorded previously and is affecting the region faster than any other place on Earth, bringing dramatic reductions in sea ice extent, altered weather, and thawing permafrost. Implications of these changes include rapid coastal erosion threatening villages and critical infrastructure, potentially significant effects on subsistence activities and cultural resources, changes to wildlife habitat, increased greenhouse-gas emissions from thawing permafrost, threat of invasive species, and opening of the Arctic Ocean to oil and gas exploration and increased shipping. The Arctic science portfolio of the U.S. Geological Survey (USGS) and its response to climate-related changes focuses on landscapescale ecosystem and natural resource issues and provides scientific underpinning for understanding the physical processes that shape the Arctic. The science conducted by the USGS informs the Nation's resource management policies and improves the stewardship of the Arctic Region.

Fragment-based lead discovery: challenges and opportunities

NASA Astrophysics Data System (ADS)

Sun, Chaohong; Petros, Andrew M.; Hajduk, Philip J.

2011-07-01

Fragment-based lead discovery has undergone remarkable changes over the last 15 years. During this time, the pharmaceutical industry has changed dramatically as well, and continued evolution of the industry is assured. These changes present many challenges but also several opportunities for executing fragment-based drug design. This article will explore some of the more significant changes in the industry and how they may affect future discovery efforts related to fragment-based initiatives.

Historical photometric evidence for volatile migration on Triton

NASA Technical Reports Server (NTRS)

Buratti, Bonnie J.; Goguen, Jay D.; Gibson, James; Mosher, Joel

1994-01-01

Analysis of CCD images of Triton obtained with the 1.5-m telescope on Palomar Mountain shows that in the time period surrounding the Voyager 2 encounter with the satellite (1985-1990), no changes in the satellite's visual albedo or color occurred. The published observations of Triton in the 0.35- to 0.60-micrometer spectral region obtained between 1950 and 1990 were reanalyzed to detect historical variability in both its albedo and visual color. Analysis of the photometry indicates that there is little, if any, change in Triton's visual geometric albedo. This result is consistent with the albedo pattern observed by Voyager and the change in sub-Earth latitude. Two distinct types of color changes are evident: a significant secular increase in the blue region of the visual spectrum since at least the 1950s, and the reported dramatic reddening of Triton's spectrum in the late 1970s. The latter change can be explained only by a short-lived geological phenomenon. Triton's changing pole orientation with respect to a terrestrial observer cannot explain the secular color changes. These changes imply volatile transport on a global scale on Triton's surface during the past 4 decades. We present two models which show that either removal of a red volatile from Triton's polar cap or deposition of a blue volatile in the equatorial regions can explain the secular color changes. A third possibility is that the changes are the result of the alpha-beta phase transition of nitrogen and subsequent fracturing of the polar cap region (N. S. Duxbury and R. H. Brown (1993).

Cognitive and affective responses to lithium in patients with organic brain syndrome.

PubMed

Williams, K H; Goldstein, G

1979-06-01

The authors describe a series of patients with organic brain syndrome who showed a dramatic clinical response to lithium carbonate therapy. None of the patients had been diagnosed as manic-depressive. Most had extensive psychiatric treatment experiences and had been given both affective and cognitive diagnoses. Six of the eight patients also qualified for the diagnosis of alcoholism. They had been treated with a wide variety of psychotherapeutic medications. Lithium was found to be rapidly and dramatically effective in patients with static lesions of the central nervous system who showed a combination of dementia and agitated depression.

Confinement and the Glass Transition Temperature in Supported Polymer Films: Molecular Weight, Repeat Unit Modification, and Cooperativity Length Scale Investigations

NASA Astrophysics Data System (ADS)

Mundra, Manish K.

2005-03-01

It is well known that the glass transition temperatures, Tgs, of supported polystyrene (PS) films decrease dramatically with decreasing film thickness below 60-80 nm. However, a detailed understanding of the cause of this effect is lacking. We have investigated the impact of several parameters, including polymer molecular weight (MW), repeat unit structure, and the length scale of cooperatively rearranging regions in bulk. There is no significant effect of PS MW on the Tg-confinement effect over a range of 5,000 to 3,000,000 g/mol. In contrast, the strength of the Tg reduction and the onset of the confinement effect increase dramatically upon changing the polymer from PS to poly(4-tert-butylstyrene) (PTBS), with PTBS exhibiting a Tg reduction relative to bulk at a thickness of 300-400 nm. PTBS also shows a Tg reduction relative to bulk of 47 K in a 21-nm-thick film, more than twice that observed in a PS film of identical thickness. Characterization of the length scale of cooperatively rearranging regions has been done by differential scanning calorimetry but reveals at best a limited correlation with the confinement effect.

Activation of peroxisome proliferator activator receptor delta in mouse impacts lipid composition and placental development at early stage of gestation.

PubMed

Ding, Hongjuan; Zhang, Yiyu; Liu, Lun; Yuan, Hongyan; Qu, Jian; Shen, Rong

2014-09-01

Peroxisome proliferator-activated receptor delta (Ppard) activation has been implicated in regulating a multitude of biological processes in placental development. In this study, we employed the UPLC-ESI-TOFMS approach to investigate the metabolic traits in placenta from GW501516-treated mice at Embryonic Day 10.5. By analyzing the mass spectrum data, ions with the most significant differences between control and GW501516-treated groups were identified. Among these metabolites, the fatty acids, phospholipids, and sterol lipids were dramatically increased. Ingenuity Pathway Analysis (IPA) showed that phosphatidylethanolamine biosynthesis and glycolysis were the top two altered metabolic pathways involved in carbohydrate metabolism, energy production, and lipid metabolism. Subsequent immunoblotting experiments provided evidence for positive correlation of PPARD level and AKT and ERK signaling pathways upon GW501516 treatment. Furthermore, the stimulation of GW501516 increased trophoblast cell fusion gene syncytin-A (Syna), but not syncytin-B (Synb), expression, suggesting a potential role of Ppard activation in promoting cytotrophoblast differentiation. Our results reveal that Ppard activation elicits dramatic changes of the metabolic activities in placenta, which is correlated to AKT and ERK signaling. © 2014 by the Society for the Study of Reproduction, Inc.

Dramatic Increases of Soil Microbial Functional Gene Diversity at the Treeline Ecotone of Changbai Mountain.

PubMed

Shen, Congcong; Shi, Yu; Ni, Yingying; Deng, Ye; Van Nostrand, Joy D; He, Zhili; Zhou, Jizhong; Chu, Haiyan

2016-01-01

The elevational and latitudinal diversity patterns of microbial taxa have attracted great attention in the past decade. Recently, the distribution of functional attributes has been in the spotlight. Here, we report a study profiling soil microbial communities along an elevation gradient (500-2200 m) on Changbai Mountain. Using a comprehensive functional gene microarray (GeoChip 5.0), we found that microbial functional gene richness exhibited a dramatic increase at the treeline ecotone, but the bacterial taxonomic and phylogenetic diversity based on 16S rRNA gene sequencing did not exhibit such a similar trend. However, the β-diversity (compositional dissimilarity among sites) pattern for both bacterial taxa and functional genes was similar, showing significant elevational distance-decay patterns which presented increased dissimilarity with elevation. The bacterial taxonomic diversity/structure was strongly influenced by soil pH, while the functional gene diversity/structure was significantly correlated with soil dissolved organic carbon (DOC). This finding highlights that soil DOC may be a good predictor in determining the elevational distribution of microbial functional genes. The finding of significant shifts in functional gene diversity at the treeline ecotone could also provide valuable information for predicting the responses of microbial functions to climate change.

Effect of Charge Patterning on the Phase Behavior of Polymer Coacervates for Charge Driven Self Assembly

NASA Astrophysics Data System (ADS)

Radhakrishna, Mithun; Sing, Charles E.

Oppositely charged polymers can undergo associative liquid-liquid phase separation when mixed under suitable conditions of ionic strength, temperature and pH to form what are known as `polymeric complex coacervates'. Polymer coacervates find use in diverse array of applications like microencapsulation, drug delivery, membrane filtration and underwater adhesives. The similarity between complex coacervate environments and those in biological systems has also found relevance in areas of bio-mimicry. Our previous works have demonstrated how local charge correlations and molecular connectivity can drastically affect the phase behavior of coacervates. The precise location of charges along the chain therefore dramatically influences the local charge correlations, which consequently influences the phase behavior of coacervates. We investigate the effect of charge patterning along the polymer chain on the phase behavior of coacervates in the framework of the Restricted Primitive Model using Gibbs Ensemble Monte Carlo simulations. Our results show that charge patterning dramatically changes the phase behavior of polymer coacervates, which contrasts with the predictions of the classical Voorn-Overbeek theory. This provides the basis for designing new materials through charge driven self assembly by controlling the positioning of the charged monomers along the chain.

Phycobilisome truncation causes widespread proteome changes in Synechocystis sp. PCC 6803

DOE PAGES

Liberton, Michelle; Chrisler, William B.; Nicora, Carrie D.; ...

2017-03-02

Here, cyanobacteria, such as Synechocystis sp. PCC 6803, utilize large antenna systems to optimize light harvesting and energy transfer to reaction centers. Understanding the structure and function of these complexes, particularly when altered, will help direct bio-design efforts to optimize biofuel production. Three specific phycobilisome (PBS) complex truncation mutants were studied, ranging from progressive truncation of phycocyanin rods in the CB and CK strains, to full removal of all phycocyanin and allophycocyanin cores in the PAL mutant. We applied comprehensive proteomic analyses to investigate both direct and downstream molecular systems implications of each truncation. Results showed that PBS truncation inmore » Synechocystis sp. PCC 6803 dramatically alters core cellular mechanisms beyond energy capture and electron transport, placing constraints upon cellular processes that dramatically altered phenotypes. This included primarily membrane associated functions and altered regulation of cellular resources (i.e., iron, nitrite/nitrate, bicarbonate). Additionally, each PBS truncation, though progressive in nature, exhibited unique phenotypes compare to WT, and hence we assert that in the current realm of extensive bioengineering and bio-design, there remains a continuing need to assess systems-wide protein based abundances to capture potential indirect phenotypic effects.« less

Phycobilisome truncation causes widespread proteome changes in Synechocystis sp. PCC 6803

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liberton, Michelle; Chrisler, William B.; Nicora, Carrie D.

Here, cyanobacteria, such as Synechocystis sp. PCC 6803, utilize large antenna systems to optimize light harvesting and energy transfer to reaction centers. Understanding the structure and function of these complexes, particularly when altered, will help direct bio-design efforts to optimize biofuel production. Three specific phycobilisome (PBS) complex truncation mutants were studied, ranging from progressive truncation of phycocyanin rods in the CB and CK strains, to full removal of all phycocyanin and allophycocyanin cores in the PAL mutant. We applied comprehensive proteomic analyses to investigate both direct and downstream molecular systems implications of each truncation. Results showed that PBS truncation inmore » Synechocystis sp. PCC 6803 dramatically alters core cellular mechanisms beyond energy capture and electron transport, placing constraints upon cellular processes that dramatically altered phenotypes. This included primarily membrane associated functions and altered regulation of cellular resources (i.e., iron, nitrite/nitrate, bicarbonate). Additionally, each PBS truncation, though progressive in nature, exhibited unique phenotypes compare to WT, and hence we assert that in the current realm of extensive bioengineering and bio-design, there remains a continuing need to assess systems-wide protein based abundances to capture potential indirect phenotypic effects.« less

Binary Black Holes, Gravitational Waves, and Numerical Relativity

NASA Technical Reports Server (NTRS)

Centrella, Joan

2008-01-01

The final merger of two black holes releases a tremendous amount of energy and is one of the brightest sources in the gravitational wave sky. Observing these sources with gravitational wave detectors requires that we know the radiation waveforms they emit. Since these mergers take place in regions of very strong gravitational fields. We need to solve Einstein's equations of general relativity on a computer in order to calculate these waveforms. For more than 30 years, scientists have tried to compute these waveforms using the methods of numerical relativity. The resulting computer codes have been plagued by instabilities, causing them to crash well before the black holes in the binary could complete even a single orbit. Recently this situation has changed dramatically, with a series of amazing breakthroughs. This talk will take you on this quest for the holy grail of numerical relativity, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by LIGO and LISA.

Binary Black Holes, Gravitational Waves, and Numerical Relativity

NASA Technical Reports Server (NTRS)

Centrella, Joan

2008-01-01

The final merger of two black holes releases a tremendous amount of energy and is one of the brightest sources in the gravitational wave sky. Observing these sources with gravitational wave detectors requires that we know the radiation waveforms they emit. Since these mergers take place in regions of very strong gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these waveforms. For more than 30 years, scientists have tried to compute these waveforms using the methods of numerical relativity. The resulting computer codes have been plagued by instabilities. causing them to crash well before the black hole:, in the binary could complete even a single orbit. Recently this situation has changed dramatically, with a series of amazing breakthroughs. This talk will take you on this quest for the holy grail of numerical relativity, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by LIGO and LISA.

Binary Black Holes, Gravitational Waves, and Numerical Relativity

NASA Technical Reports Server (NTRS)

Centrella, Joan

2008-01-01

The final merger of two black holes releases a tremendous amount of energy and is one of the brightest sources in the gravitational wave sky. Observing these sources with gravitational wave detectors requires that we know the radiation waveforms they emit. Since these mergers take place in regions of very strong gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these waveforms. For more than 30 years, scientists have tried to compute these waveforms using the methods of numerical relativity. The resulting computer codes have been plagued by instabilities, causing them to crash well before the black holes in the binary could complete even a single orbit. Recently this situation has changed dramatically, with a series of amazing breakthroughs. This talk will take you on this quest for the holy grail of numerical relativity, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by LIGO and LISA.

Binary Black Holes, Gravitational Waves, and Numerical Relativity

NASA Technical Reports Server (NTRS)

Centrella, Joan

2009-01-01

The final merger of two black holes releases a tremendous amount of energy and is one of the brightest sources in the gravitational wave sky. Observing these sources with gravitational wave detectors requires that we know the radiation waveforms they emit. Since these mergers take place in regions of very strong gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these waveforms. For more than 30 years, scientists have tried to compute these waveforms using the methods of numerical relativity. The resulting computer codes have been plagued by instabilities, causing them to crash well before the black holes in the binary could complete even a single orbit. Recently this situation has changed dramatically, with a series of amazing breakthroughs. This talk will take you on this quest for the holy grail of numerical relativity, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by LIGO and LISA.

Binary Black Holes, Gravitational Waves, and Numerical Relativity

NASA Technical Reports Server (NTRS)

Centrella, Joan

2007-01-01

The final merger of two black holes releases a tremendous amount of energy and is one of the brightest sources in the gravitational wave sky. Observing these sources with gravitational wave detectors requires that we know the radiation waveforms they emit. Since these mergers take place in regions of very strong gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these waveforms. For more than 30 years, scientists have tried to compute these waveforms using the methods of numerical relativity. The resulting computer codes have been plagued by instabilities, causing them to crash well before the black holes in the binary could complete even a single orbit. Recently this situation has changed dramatically, with a series of amazing breakthroughs. This talk will take you on this quest for the holy grail of numerical relativity, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by LIGO and LISA

Binary Black Holes, Gravitational Waves, and Numerical Relativity

NASA Technical Reports Server (NTRS)

Centrella, Joan

2007-01-01

The final merger of two black holes releases a tremendous amount of energy and is one of the brightest sources in the gravitational wave sky. Observing these sources with gravitational wave detectors requires that we know the radiation waveforms they emit. Since these mergers take place in regions of very strong gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these waveforms. For more than 30 years, scientists have tried to compute these waveforms using the methods of numerical relativity. The resulting computer codes have been plagued by instabilities, causing them to crash well before the black holes in the binary could complete even a single orbit. Recently this situation has changed dramatically, with a series of amazing breakthroughs. This talk will take you on this quest for the holy grail of numerical relativity, showing how a spacetime is constructed on a computer to build a simutation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by LIGO and LISA.

Binary Black Holes, Gravitational Waves, and Numerical Relativity

NASA Technical Reports Server (NTRS)

Centrella, Joan

2006-01-01

The final merger of two black holes releases a tremendous amount of energy and is one of the brightest sources in the gravitational wave sky. Observing these sources with gravitational wave detectors requires that we know the radiation waveforms they emit. Since these mergers take place in regions of extreme gravity, we need to solve Einstein's equations of general relativity on a computer in order to calculate these waveforms. For more than 30 years, scientists have tried to compute these waveforms using the methods of numerical relativity. The resulting computer codes have been plagued by instabilities, causing them to crash well before the black holes in the binary could complete even a single orbit. This situation has changed dramatically in the past year, with a series of amazing breakthroughs. This talk will take you on this quest for the holy grail of numerical relativity, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by LISA and LIGO.

Binary Black Holes and Gravitational Waves

NASA Technical Reports Server (NTRS)

Centrella, Joan

2007-01-01

The final merger of two black holes releases a tremendous amount of energy, more than the combined light from all the stars in the visible universe. This energy is emitted in the form of gravitational waves, and observing these sources with gravitational wave detectors such as LIGO and LISA requires that we know the pattern or fingerprint of the radiation emitted. Since black hole mergers take place in regions of extreme gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these wave patterns. For more than 30 years, scientists have tried to compute these wave patterns. However, their computer codes have been plagued by problems that caused them to crash. This situation has changed dramatically in the past 2 years, with a series of amazing breakthroughs. This discussion examines these gravitational patterns, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. The focus is on recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by the space-based gravitational wave detector LISA.

Binary Black Holes, Numerical Relativity, and Gravitational Waves

NASA Technical Reports Server (NTRS)

Centrella, Joan

2007-01-01

The final merger of two black holes releases a tremendous amount of energy, more than the combined light from all the stars in the visible universe. This energy is emitted in the form of gravitational waves, and observing these sources with gravitational wave detectors such as LISA requires that we know the pattern or fingerprint of the radiation emitted. Since black hole mergers take place in regions of extreme gravitational fields, we need to solve Einstein's equations of general relativity on a computer in order to calculate these wave patterns. For more than 30 years, scientists have tried to compute these wave patterns. However, their computer codes have been plagued by problems that caused them to crash. This situation has changed dramatically in the past 2 years, with a series of amazing breakthroughs. This talk will take you on this quest for these gravitational wave patterns, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will be observed by LISA

Cosmic Messengers: Binary Black Holes and Gravitational Waves

NASA Technical Reports Server (NTRS)

Centrella, Joan

2007-01-01

The final merger of two black holes releases a tremendous amount of energy, more than the combined light from all the stars in the visible universe. This energy is emitted in the form of gravitational waves, and observing these sources with gravitational wave detectors such as LISA requires that we know the pattern or fingerprint of the radiation emitted. Since black hole mergers take place in regions of extreme gravitational fields, we need to solve Einstein s equations of general relativity on a computer in order to calculate these wave patterns. For more than 30 years, scientists have tried to compute these wave patterns. However, their computer codes have been plagued by problems that caused them to crash. . This situation has changed dramatically in the past 2 years, with a series of amazing breakthroughs. This talk will take you on this quest for these gravitational wave patterns, showing how a spacetime is constructed on a computer to build a simulation laboratory for binary black hole mergers. We will focus on the recent advances that are revealing these waveforms, and the dramatic new potential for discoveries that arises when these sources will. be observed by LISA.

Anthropic disturbances in the sedimentological characteristics of a Northern Patagonian lake: evidencing the impacts of the 20th century settlement

NASA Astrophysics Data System (ADS)

Araneda, A.; Muñoz, V.; Valenzuela, B.; Alvarez, D.; Torrejon, F.; Pedreros, P.; Urrutia, R.

2013-12-01

Traditionally Patagonia has been seen as a very pristine area, being an important reserve of wildlife and clean waters. Nonetheless it was dramatically affected by the first settlers at the beginning of the 20th century, that generated large fires for clearing the land originally covered by native forest. Those fires produced a dramatic impact left behind thousands of dead trees, increasing soil erosion, altering nutrient inputs in the aquatic ecosystems, which in turn affected the aquatic biota. However those impacts have been barely asses, then through the study of the sediment record of lake La Esponja (45°S) we want to evaluate the magnitude of the changes produced by the fires and to determine the resilience capacity of the lake. We analyzed magnetic susceptibility, organic content, charcoal, total phosphorous and a biological proxy (Chironomidae) in a sediment sequence of 60 cm long. Magnetic susceptibility shows a very variable behavior along the profile, being possible to identify a decreasing trend since the bottom, up to the most recent part of the record. An opposite behavior describes the organic content, showing a noticeable increase toward the surficial sediments. The number of charcoal particles -a direct indicator of fires occurrence, shows a peak of fires approximately at seven cm depth, diminishing toward the recent part. Total phosphorous also follow the trend recognized by charcoal, which allow inferring a probable trophic increase of the lake. This trend is partially recognized by chironomid assemblages through the increasing of some taxa typical of a higher nutrient status. Acknowledgements: Fondecyt projects 1120765 and 1120807.

The response of lake area and vegetation cover variations to climate change over the Qinghai-Tibetan Plateau during the past 30years.

PubMed

Zhang, Zengxin; Chang, Juan; Xu, Chong-Yu; Zhou, Yang; Wu, Yanhong; Chen, Xi; Jiang, Shanshan; Duan, Zheng

2018-09-01

Lakes and vegetation are important factors of the Earth's hydrological cycle and can be called an "indicator" of climate change. In this study, long-term changes of lakes' area and vegetation coverage in the Qinghai-Tibetan Plateau (QTP) and their relations to the climate change were analyzed by using Mann-Kendall method during the past 30years. Results showed that: 1) the lakes' area of the QTP increased significantly during the past 30years as a whole, and the increasing rates have been dramatically sped up since the year of 2000. Among them, the area of Ayakekumu Lake has the fastest growing rate of 51.35%, which increased from 618km 2 in the 1980s to 983km 2 in the 2010s; 2) overall, the Normalized Difference Vegetation Index (NDVI) increased in the QTP during the past 30years. Above 79% of the area in the QTP showed increasing trend of NDVI before the year of 2000; 3) the air temperature increased significantly, the precipitation increased slightly, and the pan evaporation decreased significantly during the past 30years. The lake area and vegetation coverage changes might be related to the climate change. The shifts in the temporal climate trend occurred around the year 2000 had led the lake area and vegetation coverage increasing. This study is of importance in further understanding the environmental changes under global warming over the QTP. Copyright © 2018 Elsevier B.V. All rights reserved.

The Changing Realities of Teacher Needs.

ERIC Educational Resources Information Center

Lightfoot, Alfred

1986-01-01

The teaching profession is facing a dramatic crisis as it attempts to deal with both "quantity" (teacher shortages, rising student enrollments, teacher persistence) and "quality" (teacher competence, teacher certification, teacher testing) problems. (CB)

A Nuclear Renaissance: The Role of Nuclear Power in Mitigating Climate Change

NASA Astrophysics Data System (ADS)

Winslow, Anne

2011-06-01

The U. N. Framework Convention on Climate Change calls for the stabilization of greenhouse gas (GHG) emissions at double the preindustrial atmospheric carbon dioxide concentration to avoid dangerous anthropogenic interference with the climate system. To achieve this goal, carbon emissions in 2050 must not exceed their current level, despite predictions of a dramatic increase in global electricity demand. The need to reduce GHG emissions and simultaneously provide for additional electricity demand has led to a renewed interest in the expansion of alternatives to fossil fuels—particularly renewable energy and nuclear power. As renewable energy sources are often constrained by the intermittency of natural energy forms, scale-ability concerns, cost and environmental barriers, many governments and even prominent environmentalist turn to nuclear energy as a source of clean, reliable base-load electricity. Described by some as a "nuclear renaissance", this trend of embracing nuclear power as a tool to mitigate climate change will dramatically influence the feasibility of emerging nuclear programs around the world.

A Nuclear Renaissance: The Role of Nuclear Power in Mitigating Climate Change

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winslow, Anne

2011-06-28

The U. N. Framework Convention on Climate Change calls for the stabilization of greenhouse gas (GHG) emissions at double the preindustrial atmospheric carbon dioxide concentration to avoid dangerous anthropogenic interference with the climate system. To achieve this goal, carbon emissions in 2050 must not exceed their current level, despite predictions of a dramatic increase in global electricity demand. The need to reduce GHG emissions and simultaneously provide for additional electricity demand has led to a renewed interest in the expansion of alternatives to fossil fuels--particularly renewable energy and nuclear power. As renewable energy sources are often constrained by the intermittencymore » of natural energy forms, scale-ability concerns, cost and environmental barriers, many governments and even prominent environmentalist turn to nuclear energy as a source of clean, reliable base-load electricity. Described by some as a ''nuclear renaissance'', this trend of embracing nuclear power as a tool to mitigate climate change will dramatically influence the feasibility of emerging nuclear programs around the world.« less

From tunable core-shell nanoparticles to plasmonic drawbridges: Active control of nanoparticle optical properties

PubMed Central

Byers, Chad P.; Zhang, Hui; Swearer, Dayne F.; Yorulmaz, Mustafa; Hoener, Benjamin S.; Huang, Da; Hoggard, Anneli; Chang, Wei-Shun; Mulvaney, Paul; Ringe, Emilie; Halas, Naomi J.; Nordlander, Peter; Link, Stephan; Landes, Christy F.

2015-01-01

The optical properties of metallic nanoparticles are highly sensitive to interparticle distance, giving rise to dramatic but frequently irreversible color changes. By electrochemical modification of individual nanoparticles and nanoparticle pairs, we induced equally dramatic, yet reversible, changes in their optical properties. We achieved plasmon tuning by oxidation-reduction chemistry of Ag-AgCl shells on the surfaces of both individual and strongly coupled Au nanoparticle pairs, resulting in extreme but reversible changes in scattering line shape. We demonstrated reversible formation of the charge transfer plasmon mode by switching between capacitive and conductive electronic coupling mechanisms. Dynamic single-particle spectroelectrochemistry also gave an insight into the reaction kinetics and evolution of the charge transfer plasmon mode in an electrochemically tunable structure. Our study represents a highly useful approach to the precise tuning of the morphology of narrow interparticle gaps and will be of value for controlling and activating a range of properties such as extreme plasmon modulation, nanoscopic plasmon switching, and subnanometer tunable gap applications. PMID:26665175

The Changing South Polar Cap of Mars: 1999-2005

NASA Technical Reports Server (NTRS)

2005-01-01

13 July 2005 The south polar residual cap of Mars is composed of layered, frozen carbon dioxide. In 1999, the Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) showed that the carbon dioxide layers have been eroded to form a variety of circular pits, arcuate scarps, troughs, buttes, and mesas. In 2001, MOC images designed to provide repeated views of the areas imaged in 1999 -- with the hope of creating stereo (3-D) images, so that the height of scarps and depth of pits could be measured -- showed that the scarps had retreated, pits enlarged, and buttes and mesas shrank. Only carbon dioxide is volatile enough in the martian environment to have caused such dramatic changes -- the scarps were seen to retreat at an average rate of 3 meters (about 3 yards) per Mars year. Most of the scarp retreat occurs during the southern summer season; in some areas the scarps move as much as 8 meters, in others, only 1 meter per Mars year.

Three Mars years have now elapsed since MOC first surveyed the south polar cap in 1999. Over the past several months, MGS MOC has been re-imaging areas that were seen in 1999, 2001, and 2003, to develop a detailed look at how the landscape has been changing. This animated GIF provides an example of the dramatic changes that have occurred during the past three martian years. The first image, a sub-frame of M09-05244, was acquired on 21 November 1999. The second image, a sub-frame of S06-00973, was obtained on 11 May 2005. The animation shows the changes that have occurred between 1999 and 2005. Each summer, the cap has lost more carbon dioxide. This may mean that the carbon dioxide content of the martian atmosphere has been increasing, bit by very tiny little bit, each of the years that MGS has been orbiting the red planet. These observations also imply that there was once a time, in the not-too-distant past (because there are no impact craters on the polar cap), when the atmosphere was somewhat thinner and colder, to permit the layers of carbon dioxide to form in the first place. Just as Earth's environment is very different today than it was just 11,000 or so years ago, the martian environment has also been changing on a similar time scale.

Location near: 88.9oS, 25.7oW Image width: width: 0.6 km (0.4 mi) Illumination from: upper left Season: Southern Spring

The effect of anatomic variations of circle of Willis on cerebral blood distribution during posture change from supination to standing: a model study.

PubMed

Zhang, Chi; Li, Shuyu; Pu, Fang; Fan, Yubo; Li, Deyu

2014-01-01

The anatomic variation of Circle of Willis (CoW) has great impact on its compensatory capacity during stroke and cerebral ischemia. In the present study, a series of lumped parameter models were developed and used to simulate the effect of postural changes on the cerebral blood flow in ICA stenosis patients with different anatomic variants of the CoW. The results showed that the asymmetric distribution of cerebral blood flow caused by stenosis was attenuated in standing position in complete and half-complete CoW. However, in incomplete CoW, the decrease in blood flow in the ipsilateral cerebral arteries caused by unilateral ICA stenosis was dramatic in both supine and standing positions, a likely result of inadequate collateral circulation within the CoW. In conclusion, the anatomic variation of CoW plays a significant role in maintaining the balance of cerebral blood supply in patients with ICA stenosis, especially during postural change.

Modeled historical land use and land cover for the conterminous United States

USGS Publications Warehouse

Sohl, Terry L.; Reker, Ryan R.; Bouchard, Michelle A.; Sayler, Kristi L.; Dornbierer, Jordan; Wika, Steve; Quenzer, Robert; Friesz, Aaron M.

2016-01-01

The landscape of the conterminous United States has changed dramatically over the last 200 years, with agricultural land use, urban expansion, forestry, and other anthropogenic activities altering land cover across vast swaths of the country. While land use and land cover (LULC) models have been developed to model potential future LULC change, few efforts have focused on recreating historical landscapes. Researchers at the US Geological Survey have used a wide range of historical data sources and a spatially explicit modeling framework to model spatially explicit historical LULC change in the conterminous United States from 1992 back to 1938. Annual LULC maps were produced at 250-m resolution, with 14 LULC classes. Assessment of model results showed good agreement with trends and spatial patterns in historical data sources such as the Census of Agriculture and historical housing density data, although comparison with historical data is complicated by definitional and methodological differences. The completion of this dataset allows researchers to assess historical LULC impacts on a range of ecological processes.

Nitric Oxide Is an Activity-Dependent Regulator of Target Neuron Intrinsic Excitability

PubMed Central

Steinert, Joern R.; Robinson, Susan W.; Tong, Huaxia; Haustein, Martin D.; Kopp-Scheinpflug, Cornelia; Forsythe, Ian D.

2011-01-01

Summary Activity-dependent changes in synaptic strength are well established as mediating long-term plasticity underlying learning and memory, but modulation of target neuron excitability could complement changes in synaptic strength and regulate network activity. It is thought that homeostatic mechanisms match intrinsic excitability to the incoming synaptic drive, but evidence for involvement of voltage-gated conductances is sparse. Here, we show that glutamatergic synaptic activity modulates target neuron excitability and switches the basis of action potential repolarization from Kv3 to Kv2 potassium channel dominance, thereby adjusting neuronal signaling between low and high activity states, respectively. This nitric oxide-mediated signaling dramatically increases Kv2 currents in both the auditory brain stem and hippocampus (>3-fold) transforming synaptic integration and information transmission but with only modest changes in action potential waveform. We conclude that nitric oxide is a homeostatic regulator, tuning neuronal excitability to the recent history of excitatory synaptic inputs over intervals of minutes to hours. PMID:21791288

Chromaticity of gravitational microlensing events

NASA Astrophysics Data System (ADS)

Han, Cheongho; Park, Seong-Hong; Jeong, Jang-Hae

2000-07-01

In this paper, we investigate the colour changes of gravitational microlensing events caused by the two different mechanisms of differential amplification for a limb-darkened extended source and blending. From this investigation, we find that the colour changes of limb-darkened extended source events (colour curves) have dramatically different characteristics depending on whether the lens transits the source star or not. We show that for a source transit event, the lens proper motion can be determined by simply measuring the turning time of the colour curve instead of fitting the overall colour or light curves. We also find that even for a very small fraction of blended light, the colour changes induced by blending are equivalent to those induced by limb darkening, causing serious distortion in the observed colour curve. Therefore, to obtain useful information about the lens and source star from the colour curve of an event, it will be essential to correct for blending. We discuss various methods of blending correction.

Offline impedance measurements for detection and mitigation of dangerous implant interactions: an RF safety prescreen.

PubMed

Ellenor, Christopher W; Stang, Pascal P; Etezadi-Amoli, Maryam; Pauly, John M; Scott, Greig C

2015-03-01

The concept of a "radiofrequency safety prescreen" is investigated, wherein dangerous interactions between radiofrequency fields used in MRI, and conductive implants in patients are detected through impedance changes in the radiofrequency coil. The behavior of coupled oscillators is reviewed, and the resulting, observable impedance changes are discussed. A birdcage coil is loaded with a static head phantom and a wire phantom with a wire close to its resonant length, the shape, position, and orientation of which can be changed. Interactions are probed with a current sensor and network analyzer. Impedance spectra show dramatic, unmistakable splitting in cases of strong coupling, and strong correlation is observed between induced current and scattering parameters. The feasibility of a new, low-power prescreening technique has been demonstrated in a simple phantom experiment, which can unambiguously detect resonant interactions between an implanted wire and an imaging coil. A new technique has also been presented which can detect parallel transmit null modes for the wire. © 2014 Wiley Periodicals, Inc.

Temporal and spatial change in coastal ecosystems using remote sensing: Example with Florida Bay, USA, emphasizing AVHRR imagery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stumpf, R.P.; Frayer, M.L.

1997-06-01

Florida Bay, at the southern tip of Florida, USA, has undergone dramatic changes in recent years. Following seagrass dieoffs starting in the late 1980`s, both algal blooms and high turbidity (the latter from resuspended sediments) have been reported as more common in the Bay. Remotely sensed data, particularly from the AVHRR (advanced very high resolution radiometer), can provide information on conditions prior to the start of monitoring programs as well as provide additional spatial detail on water clarity and particulate loads in this estuary . The AVHRR record currently available to us consists of over 600 usable scenes from December,more » 1989. Comparisons with field data have provided relationships with light attenuation, total suspended solids, and other turbidity measures. The imagery shows the seasonal change in turbidity resulting from high winds associated with winter cold fronts. Over the seven-year record, areas of clear water have decreased in the north-central Bay, while expanding in the southwestern Bay.« less

Species-specific responses of Late Quaternary megafauna to climate and humans

PubMed Central

Lorenzen, Eline D.; Nogués-Bravo, David; Orlando, Ludovic; Weinstock, Jaco; Binladen, Jonas; Marske, Katharine A.; Ugan, Andrew; Borregaard, Michael K.; Gilbert, M. Thomas P.; Nielsen, Rasmus; Ho, Simon Y. W.; Goebel, Ted; Graf, Kelly E.; Byers, David; Stenderup, Jesper T.; Rasmussen, Morten; Campos, Paula F.; Leonard, Jennifer A.; Koepfli, Klaus-Peter; Froese, Duane; Zazula, Grant; Stafford, Thomas W.; Aaris-Sørensen, Kim; Batra, Persaram; Haywood, Alan M.; Singarayer, Joy S.; Valdes, Paul J.; Boeskorov, Gennady; Burns, James A.; Davydov, Sergey P.; Haile, James; Jenkins, Dennis L.; Kosintsev, Pavel; Kuznetsova, Tatyana; Lai, Xulong; Martin, Larry D.; McDonald, H. Gregory; Mol, Dick; Meldgaard, Morten; Munch, Kasper; Stephan, Elisabeth; Sablin, Mikhail; Sommer, Robert S.; Sipko, Taras; Scott, Eric; Suchard, Marc A.; Tikhonov, Alexei; Willerslev, Rane; Wayne, Robert K.; Cooper, Alan; Hofreiter, Michael; Sher, Andrei; Shapiro, Beth; Rahbek, Carsten; Willerslev, Eske

2014-01-01

Despite decades of research, the roles of climate and humans in driving the dramatic extinctions of large-bodied mammals during the Late Quaternary remain contentious. We use ancient DNA, species distribution models and the human fossil record to elucidate how climate and humans shaped the demographic history of woolly rhinoceros, woolly mammoth, wild horse, reindeer, bison and musk ox. We show that climate has been a major driver of population change over the past 50,000 years. However, each species responds differently to the effects of climatic shifts, habitat redistribution and human encroachment. Although climate change alone can explain the extinction of some species, such as Eurasian musk ox and woolly rhinoceros, a combination of climatic and anthropogenic effects appears to be responsible for the extinction of others, including Eurasian steppe bison and wild horse. We find no genetic signature or any distinctive range dynamics distinguishing extinct from surviving species, underscoring the challenges associated with predicting future responses of extant mammals to climate and human-mediated habitat change. PMID:22048313

Space and time scales in human-landscape systems.

PubMed

Kondolf, G Mathias; Podolak, Kristen

2014-01-01

Exploring spatial and temporal scales provides a way to understand human alteration of landscape processes and human responses to these processes. We address three topics relevant to human-landscape systems: (1) scales of human impacts on geomorphic processes, (2) spatial and temporal scales in river restoration, and (3) time scales of natural disasters and behavioral and institutional responses. Studies showing dramatic recent change in sediment yields from uplands to the ocean via rivers illustrate the increasingly vast spatial extent and quick rate of human landscape change in the last two millennia, but especially in the second half of the twentieth century. Recent river restoration efforts are typically small in spatial and temporal scale compared to the historical human changes to ecosystem processes, but the cumulative effectiveness of multiple small restoration projects in achieving large ecosystem goals has yet to be demonstrated. The mismatch between infrequent natural disasters and individual risk perception, media coverage, and institutional response to natural disasters results in un-preparedness and unsustainable land use and building practices.

Human resources in the 1980s.

PubMed

Mills, D Q

1979-01-01

As the decade of the 1970s closes, new trends in human resources will test the ingenuity of corporate planners to produce policies for the 1980s that will match changing corporate demands with changing employee expectations. The 1970s have produced much-publicized problems--for example, the introduction to the work force of larger numbers of minorities and women--that are not yet fully resolved and that can be expected to continue. But the 1980s will bring their own special challenges. Shifting populations (such as legal and illegal immigrants), the women's movement's demand for equal pay for work of comparable worth, and the push for civil liberties at the workplace are all factors that will dramatically change the business climate. With these factors in mind, the author examines the 1980s' business environment, takes a backward look at planning policies in the 1970s, and shows how the priorities of those policies will have to be reevaluated to meet the challenges of the future.

Eastern Indian Ocean microcontinent formation driven by plate motion changes

NASA Astrophysics Data System (ADS)

Whittaker, J. M.; Williams, S. E.; Halpin, J. A.; Wild, T. J.; Stilwell, J. D.; Jourdan, F.; Daczko, N. R.

2016-11-01

The roles of plate tectonic or mantle dynamic forces in rupturing continental lithosphere remain controversial. Particularly enigmatic is the rifting of microcontinents from mature continental rifted margins, with plume-driven thermal weakening commonly inferred to facilitate calving. However, a role for plate tectonic reorganisations has also been suggested. Here, we show that a combination of plate tectonic reorganisation and plume-driven thermal weakening were required to calve the Batavia and Gulden Draak microcontinents in the Cretaceous Indian Ocean. We reconstruct the evolution of these two microcontinents using constraints from new paleontological samples, 40Ar/39Ar ages, and geophysical data. Calving from India occurred at 101-104 Ma, coinciding with the onset of a dramatic change in Indian plate motion. Critically, Kerguelen plume volcanism does not appear to have directly triggered calving. Rather, it is likely that plume-related thermal weakening of the Indian passive margin preconditioned it for microcontinent formation but calving was triggered by changes in plate tectonic boundary forces.

Activation and proliferation of lymphocytes and other mammalian cells in microgravity

NASA Technical Reports Server (NTRS)

Cogoli, A.; Cogoli-Greuter, M.

1997-01-01

The experimental findings reviewed in this chapter support the following conclusions: Proliferation. Human T-lymphocytes, associated with monocytes as accessory cells, show dramatic changes in the centrifuge, in the clinostat and in space. In free-floating cells the mitogenic response is depressed by 90% in microgravity, whereas in cells attached to a substratum activation is enhanced by 100% compared to 1-G ground and inflight controls. The duration of phase G1 of the mitotic cycle of HeLa cells is reduced in hypergravity, resulting in an increased proliferation rate. Other systems like Friend cells and WI38 human embryonic lung cells do not show significant changes. Genetic expression and signal transduction. T-lymphocytes and monocytes show important changes in the expression of cytokines like interleukin-1, interleukin-2, interferon-gamma and tumor necrosis factor. The data from space experiments in Spacelab, Space Shuttle mid-deck, and Biokosmos have helped to clarify certain aspects of the mechanism of T-cell activation. Epidermoid A431 cells show changes in the genetic expression of the proto-oncogenes c-fos and c-jun in the clinostat and in sounding rockets. Membrane function, in particular the binding of ligates as first messengers of a signal, is not changed in most of the cell systems in microgravity. Morphology and Mortility. Free cells, lymphocytes in particular, are able to move and form aggregates in microgravity, indicating that cell-cell contacts and cell communications do take place in microgravity. Dramatic morphological and ultrastructural changes are not detected in cells cultured in microgravity. Important experiments with single mammalian cells, including immune cells, were carried out recently in three Spacelab flights, (SL-J, D-2, and IML-2 in 1992, 1993, and 1994, respectively). The results of the D-2 mission have been published in ref. 75; those of the IML-2 mission in ref. 76. Finally, many cell biology experiments in space have suffered in the past from a lack of adequate controls (like 1-G centrifuges) and of proper experimental conditions (like well-controlled temperature). In this respect the availability of Biorack, outfitted with proper incubators with 1-G control centrifuge as well as a glovebox with a microscope, is a great advantage. It is also desirable that cell biology experiments in space are accompanied or even preceded by a program of ground-based investigations in the fast rotating clinostat and in the centrifuge, and that preparatory experiments be done in parabolic flights and sounding rockets, whenever possible. Proper publication of the results of space experiments is another important need. A great number of data have been published in proceedings and reports that are not available to the broad scientific community. To guarantee the credibility and the international recognition of space biology it is important that the results be published in international, peer reviewed journals.

Conjugated polymers: Watching polymers dance

NASA Astrophysics Data System (ADS)

Rothberg, Lewis

2011-06-01

Single-molecule spectroscopy allows fluctuations of conjugated polymer conformation to be monitored during solvent vapour annealing. Dramatic changes in fluorescence behaviour are observed and interpreted in terms of transformations between extended and collapsed polymer geometries.

Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones

PubMed Central

Hansen, R K; Bissell, M J

2010-01-01

The changes in tissue architecture that accompany the development of breast cancer have been the focus of investigations aimed at developing new cancer therapeutics. As we learn more about the normal mammary gland, we have begun to understand the complex signaling pathways underlying the dramatic shifts in the structure and function of breast tissue. Integrin-, growth factor-, and steroid hormone-signaling pathways all play an important part in maintaining tissue architecture; disruption of the delicate balance of signaling results in dramatic changes in the way cells interact with each other and with the extracellular matrix, leading to breast cancer. The extracellular matrix itself plays a central role in coordinating these signaling processes. In this review, we consider the interrelationships between the extracellular matrix, integrins, growth factors, and steroid hormones in mammary gland development and function. PMID:10903527

Spatio-temporal change in forest cover and carbon storage considering actual and potential forest cover in South Korea.

PubMed

Nam, Kijun; Lee, Woo-Kyun; Kim, Moonil; Kwak, Doo-Ahn; Byun, Woo-Hyuk; Yu, Hangnan; Kwak, Hanbin; Kwon, Taesung; Sung, Joohan; Chung, Dong-Jun; Lee, Seung-Ho

2015-07-01

This study analyzes change in carbon storage by applying forest growth models and final cutting age to actual and potential forest cover for six major tree species in South Korea. Using National Forest Inventory data, the growth models were developed to estimate mean diameter at breast height, tree height, and number of trees for Pinus densiflora, Pinus koraiensis, Pinus rigida, Larix kaempferi, Castanea crenata and Quercus spp. stands. We assumed that actual forest cover in a forest type map will change into potential forest covers according to the Hydrological and Thermal Analogy Groups model. When actual forest cover reaches the final cutting age, forest volume and carbon storage are estimated by changed forest cover and its growth model. Forest volume between 2010 and 2110 would increase from 126.73 to 157.33 m(3) hm(-2). Our results also show that forest cover, volume, and carbon storage could abruptly change by 2060. This is attributed to the fact that most forests are presumed to reach final cutting age. To avoid such dramatic change, a regeneration and yield control scheme should be prepared and implemented in a way that ensures balance in forest practice and yield.

IR Variability of Eta Carinae

NASA Astrophysics Data System (ADS)

Smith, Nathan

2007-02-01

Every 5.5 years, η Carinae experiences a dramatic ``spectroscopic event'' when high-excitation lines in its UV, optical, and IR spectrum disappear, and its hard X-ray and radio continuum flux crash. This periodicity has been attributed to an eccentric binary system with a shell ejection occurring at periastron. In addition, η Car shows long term changes as it is still recovering from its giant 19th century outburst. Both types of variability are directly linked to the current mass-loss rate and dust formation in its wind. Mid-IR images and spectra with T-ReCS provide a direct measure of changes in the current bolometric luminosity and trace dust formation episodes. This will provide a direct measurement of the mass ejected. Near-IR emission lines trace related changes in the post-event wind and ionization changes in the circumstellar environment needed to test specific models for the cause of η Car's variability as it recovers from its recent ``event''. High resolution near-IR spectra with GNIRS will continue the important work of HST/STIS, investigating changes in the direct and reflected spectrum of the stellar wind, and ionization changes in the nebula.

Middle Holocene rapid environmental changes and human adaptation in Greece

NASA Astrophysics Data System (ADS)

Lespez, Laurent; Glais, Arthur; Lopez-Saez, José-Antonio; Le Drezen, Yann; Tsirtsoni, Zoï; Davidson, Robert; Biree, Laetitia; Malamidou, Dimitra

2016-03-01

Numerous researchers discuss of the collapse of civilizations in response to abrupt climate change in the Mediterranean region. The period between 6500 and 5000 cal yr BP is one of the least studied episodes of rapid climate change at the end of the Late Neolithic. This period is characterized by a dramatic decline in settlement and a cultural break in the Balkans. High-resolution paleoenvironmental proxy data obtained in the Lower Angitis Valley enables an examination of the societal responses to rapid climatic change in Greece. Development of a lasting fluvio-lacustrine environment followed by enhanced fluvial activity is evident from 6000 cal yr BP. Paleoecological data show a succession of dry events at 5800-5700, 5450 and 5000-4900 cal yr BP. These events correspond to incursion of cold air masses to the eastern Mediterranean, confirming the climatic instability of the middle Holocene climate transition. Two periods with farming and pastural activities (6300-5600 and 5100-4700 cal BP) are evident. The intervening period is marked by environmental changes, but the continuous occurrence of anthropogenic taxa suggests the persistence of human activities despite the absence of archaeological evidence. The environmental factors alone were not sufficient to trigger the observed societal changes.

Dramatic Change in Jupiter's Great Red Spot from Spacecraft Observations

NASA Technical Reports Server (NTRS)

Simon, Amy A.; Wong, Michael H.; Rogers, John H.; Orton, Glenn S.; de Pater, Imke; Asay-Davis, Xylar; Carlson, Robert W.; Marcus, Philip S.

2015-01-01

Jupiter's Great Red Spot (GRS) is one of its most distinct and enduring features. Since the advent of modern telescopes, keen observers have noted its appearance and documented a change in shape from very oblong to oval, confirmed in measurements from spacecraft data. It currently spans the smallest latitude and longitude size ever recorded. Here we show that this change has been accompanied by an increase in cloud/haze reflectance as sensed in methane gas absorption bands, increased absorption at wavelengths shorter than 500 nanometers, and increased spectral slope between 500 and 630 nanometers. These changes occurred between 2012 and 2014, without a significant change in internal tangential wind speeds; the decreased size results in a 3.2 day horizontal cloud circulation period, shorter than previously observed. As the GRS has narrowed in latitude, it interacts less with the jets flanking its north and south edges, perhaps allowing for less cloud mixing and longer UV irradiation of cloud and aerosol particles. Given its long life and observational record, we expect that future modeling of the GRS's changes, in concert with laboratory flow experiments, will drive our understanding of vortex evolution and stability in a confined flow field crucial for comparison with other planetary atmospheres.

Modeling the Fear Effect in Predator-Prey Interactions with Adaptive Avoidance of Predators.

PubMed

Wang, Xiaoying; Zou, Xingfu

2017-06-01

Recent field experiments on vertebrates showed that the mere presence of a predator would cause a dramatic change of prey demography. Fear of predators increases the survival probability of prey, but leads to a cost of prey reproduction. Based on the experimental findings, we propose a predator-prey model with the cost of fear and adaptive avoidance of predators. Mathematical analyses show that the fear effect can interplay with maturation delay between juvenile prey and adult prey in determining the long-term population dynamics. A positive equilibrium may lose stability with an intermediate value of delay and regain stability if the delay is large. Numerical simulations show that both strong adaptation of adult prey and the large cost of fear have destabilizing effect while large population of predators has a stabilizing effect on the predator-prey interactions. Numerical simulations also imply that adult prey demonstrates stronger anti-predator behaviors if the population of predators is larger and shows weaker anti-predator behaviors if the cost of fear is larger.

Enantiomers of Single-Wall Carbon Nanotubes Show Distinct Coating Displacement Kinetics.

PubMed

Zheng, Yu; Bachilo, Sergei M; Weisman, R Bruce

2018-06-27

It is known that specific oligomers of single-stranded DNA (ssDNA) can show remarkable selectivity when coating different structural species of single-wall carbon nanotubes (SWCNTs). We report that (ATT) 4 ssDNA coatings strongly distinguish between the two optical isomers of (7,5) SWCNTs. This causes resolvable shifts in their fluorescence spectra and differences of 2 orders of magnitude in the room temperature rates of coating displacement, as monitored through changes in nanotube fluorescence wavelength and intensity on exposure to sodium deoxycholate. During coating displacement, the enantiomer with high affinity for the ssDNA oligomer is deduced to form an intermediate hybrid that is not observed for the low affinity enantiomer. These results reveal that enantiomeric differences in SWCNTs complexed with ssDNA are more diverse and dramatic than previously recognized.

[Modeling and experimental study on frequency-domain electricity properties of biological materials].

PubMed

Tian, Hua; Luo, Shiqiang; Zhang, Rui; Yang, Gang; Huang, Hua

2009-12-01

Frequency-domain electricity properties of four objects, including bullfrog skin, bullfrog muscle, triply distilled water and 0.9% NaCl, were tested in the range of 100Hz-10MHz using home-made electrode and measuring system. The experimental results showed that the resistance of 0.9% NaCl decreased dramatically, that the amplitude frequency characteristics of bullfrog's muscle and skin were similar, but that of triply distilled water did not change significantly. The frequency dependence of 0.9% NaCl showed that the electrode had great influence on the measuring system, so a new equivalent circuit model based on the electrode system was needed. These findings suggest that the new five-parameter equivalent circuit model, which embodies considerations on the interaction between electrodes and tissues, is a reasonable equivalent circuit for studying the electrical characteristics of biological materials.

A low energy demand scenario for meeting the 1.5 °C target and sustainable development goals without negative emission technologies

NASA Astrophysics Data System (ADS)

Grubler, Arnulf; Wilson, Charlie; Bento, Nuno; Boza-Kiss, Benigna; Krey, Volker; McCollum, David L.; Rao, Narasimha D.; Riahi, Keywan; Rogelj, Joeri; De Stercke, Simon; Cullen, Jonathan; Frank, Stefan; Fricko, Oliver; Guo, Fei; Gidden, Matt; Havlík, Petr; Huppmann, Daniel; Kiesewetter, Gregor; Rafaj, Peter; Schoepp, Wolfgang; Valin, Hugo

2018-06-01

Scenarios that limit global warming to 1.5 °C describe major transformations in energy supply and ever-rising energy demand. Here, we provide a contrasting perspective by developing a narrative of future change based on observable trends that results in low energy demand. We describe and quantify changes in activity levels and energy intensity in the global North and global South for all major energy services. We project that global final energy demand by 2050 reduces to 245 EJ, around 40% lower than today, despite rises in population, income and activity. Using an integrated assessment modelling framework, we show how changes in the quantity and type of energy services drive structural change in intermediate and upstream supply sectors (energy and land use). Down-sizing the global energy system dramatically improves the feasibility of a low-carbon supply-side transformation. Our scenario meets the 1.5 °C climate target as well as many sustainable development goals, without relying on negative emission technologies.

Record-Breaking Early Flowering in the Eastern United States

PubMed Central

Ellwood, Elizabeth R.; Temple, Stanley A.; Primack, Richard B.; Davis, Charles C.

2013-01-01

Flowering times are well-documented indicators of the ecological effects of climate change and are linked to numerous ecosystem processes and trophic interactions. Dozens of studies have shown that flowering times for many spring-flowering plants have become earlier as a result of recent climate change, but it is uncertain if flowering times will continue to advance as temperatures rise. Here, we used long-term flowering records initiated by Henry David Thoreau in 1852 and Aldo Leopold in 1935 to investigate this question. Our analyses demonstrate that record-breaking spring temperatures in 2010 and 2012 in Massachusetts, USA, and 2012 in Wisconsin, USA, resulted in the earliest flowering times in recorded history for dozens of spring-flowering plants of the eastern United States. These dramatic advances in spring flowering were successfully predicted by historical relationships between flowering and spring temperature spanning up to 161 years of ecological change. These results demonstrate that numerous temperate plant species have yet to show obvious signs of physiological constraints on phenological advancement in the face of climate change. PMID:23342001

Landscape metrics for assessment of landscape destruction and rehabilitation.

PubMed

Herzog, F; Lausch, A; Müller, E; Thulke, H H; Steinhardt, U; Lehmann, S

2001-01-01

This investigation tested the usefulness of geometry-based landscape metrics for monitoring landscapes in a heavily disturbed environment. Research was carried out in a 75 sq km study area in Saxony, eastern Germany, where the landscape has been affected by surface mining and agricultural intensification. Landscape metrics were calculated from digital maps (1912, 1944, 1973, 1989) for the entire study area and for subregions (river valleys, plains), which were defined using the original geology and topography of the region. Correlation and factor analyses were used to select a set of landscape metrics suitable for landscape monitoring. Little land-use change occurred in the first half of the century, but political decisions and technological developments led to considerable change later. Metrics showed a similar pattern with almost no change between 1912 and 1944, but dramatic changes after 1944. Nonparametric statistical methods were used to test whether metrics differed between river valleys and plains. Significant differences in the metrics for these regions were found in the early maps (1912, 1944), but these differences were not significant in 1973 or 1989. These findings indicate that anthropogenic influences created a more home geneous landscape.

The Flavonoid Pathway Regulates the Petal Colors of Cotton Flower

PubMed Central

Tan, Jiafu; Wang, Maojun; Tu, Lili; Nie, Yichun; Lin, Yongjun; Zhang, Xianlong

2013-01-01

Although biochemists and geneticists have studied the cotton flower for more than one century, little is known about the molecular mechanisms underlying the dramatic color change that occurs during its short developmental life following blooming. Through the analysis of world cotton germplasms, we found that all of the flowers underwent color changes post-anthesis, but there is a diverse array of petal colors among cotton species, with cream, yellow and red colors dominating the color scheme. Genetic and biochemical analyses indicated that both the original cream and red colors and the color changes post-anthesis were related to flavonoid content. The anthocyanin content and the expression of biosynthesis genes were both increased from blooming to one day post-anthesis (DPA) when the flower was withering and undergoing abscission. Our results indicated that the color changes and flavonoid biosynthesis of cotton flowers were precisely controlled and genetically regulated. In addition, flavonol synthase (FLS) genes involved in flavonol biosynthesis showed specific expression at 11 am when the flowers were fully opened. The anthocyanidin reductase (ANR) genes, which are responsible for proanthocyanidins biosynthesis, showed the highest expression at 6 pm on 0 DPA, when the flowers were withered. Light showed primary, moderate and little effects on flavonol, anthocyanin and proanthocyanidin biosynthesis, respectively. Flavonol biosynthesis was in response to light exposure, while anthocyanin biosynthesis was involved in flower color changes. Further expression analysis of flavonoid genes in flowers of wild type and a flavanone 3-hydroxylase (F3H) silenced line showed that the development of cotton flower color was controlled by a complex interaction between genes and light. These results present novel information regarding flavonoids metabolism and flower development. PMID:23951318

Temporal and diurnal analysis of trace elements in the Cryospheric water at remote Laohugou basin in northeast Tibetan Plateau.

PubMed

Dong, Zhiwen; Kang, Shichang; Qin, Dahe; Qin, Xiang; Yan, Fangping; Du, Wentao; Wei, Ting

2017-03-01

An evaluation of glacial meltwater chemistry is needed under recent dramatic glacier melting when water resources might be significantly impacted. This study investigated trace elements variation in the meltwater stream, and its related aquatic environmental information, at the Laohugou (LHG) glacier basin (4260 m a.s.l.) at a remote location in northeast Tibetan Plateau. We focused on the spatial, temporal and diurnal change of trace elements during the glacier ablation period. Results showed evident elements spatial difference on the glacier surface meltwater, as most of the elements showed increased concentration at the terminus compared to higher elevations sites. Dominant elements in the meltwater were Ba, Sr and Cr, whereas elements with high enrichment factors (EFs) were Sb, Ni, Mo and Zn. Temporal change of some trace elements concentration (e.g. Sc, Cu, and Rb) indicated increasing trend with accelerated snow-ice melting, whereas others (e.g. Ni, Zn, and Pb) showed decreasing trend. We find that, trace elements showed evident diurnal change and a peak value of concentration was observed each day at about 15:00-17:00, and the diurnal change was influenced by runoff level and pH. Moreover, EFs calculations revealed that heavy metals were partially originated from regional anthropogenic sources. Overall, the accelerated diurnal and temporal snow-ice melting (with high runoff level) were correlated to increased elemental concentration, pH, EC and elemental change mode, and thus this work is of great importance for evaluating the impacts of accelerated glacier melting to meltwater chemistry and downstream ecosystem in the northeast Tibetan Plateau. Copyright © 2016 Elsevier Ltd. All rights reserved.

Viewpoint and pose in body-form adaptation.

PubMed

Sekunova, Alla; Black, Michael; Parkinson, Laura; Barton, Jason J S

2013-01-01

Faces and bodies are complex structures, perception of which can play important roles in person identification and inference of emotional state. Face representations have been explored using behavioural adaptation: in particular, studies have shown that face aftereffects show relatively broad tuning for viewpoint, consistent with origin in a high-level structural descriptor far removed from the retinal image. Our goals were to determine first, if body aftereffects also showed a degree of viewpoint invariance, and second if they also showed pose invariance, given that changes in pose create even more dramatic changes in the 2-D retinal image. We used a 3-D model of the human body to generate headless body images, whose parameters could be varied to generate different body forms, viewpoints, and poses. In the first experiment, subjects adapted to varying viewpoints of either slim or heavy bodies in a neutral stance, followed by test stimuli that were all front-facing. In the second experiment, we used the same front-facing bodies in neutral stance as test stimuli, but compared adaptation from bodies in the same neutral stance to adaptation with the same bodies in different poses. We found that body aftereffects were obtained over substantial viewpoint changes, with no significant decline in aftereffect magnitude with increasing viewpoint difference between adapting and test images. Aftereffects also showed transfer across one change in pose but not across another. We conclude that body representations may have more viewpoint invariance than faces, and demonstrate at least some transfer across pose, consistent with a high-level structural description.

Tipping points in Anthropocene fluvial dynamics

NASA Astrophysics Data System (ADS)

Notebaert, Bastiaan; Broothaerts, Nils; Verstraeten, Gert; Berger, Jean-François; Houbrechts, Geoffrey

2016-04-01

Many rivers have undergone dramatic changes over the last millennia due to anthropogenic on- and offsite impacts. These changes have important implications for the geomorphic and hydrological functioning of the river. In this study we compare the influence of large-scaled off-site anthropogenic impact on three European river systems. We do this using traditional geomorphological methods, combined with palynological and archaeological data; for each catchment a Holocene sediment budget was constructed. The Dijle catchment is located in the central Belgian loess belt, and has undergone intense agriculture for at least the last 2000 year. Pre-Anthropocene floodplain are big marshes lacking a well-established river channel. Anthropogenic deforestation in the headwaters resulted in a sediment pulse from the Bronze Age on. In the main floodplain sediments gradually covered the peat layer, starting near a newly formed river channel and expanding over time towards the floodplain edges. In contrast, this transition is abrupt in the smaller tributary floodplains. Comparison with palynological data shows that this abrupt transition occurs when human impact reaches a certain threshold. The Valdaine region is located in the French Pre-Alps. Floodplain deposition increased over time since the Neolithic time period due to human induced and fire related soil erosion. This general aggradation trend is however interrupted by three major river incision phases which are caused by human land abandonment and dry periods. A second major change in floodplain geomorphology occurs during the High Roman Period and the last 800 year: the fine-grained meandering river changes to a gravel loaded braided river. During this period the upstream mountain reaches became a major sediment source due to deforestation, possibly combined with climate change. During the last century reforestation and land abandonment has led to a new incision phases, and floodplain are now a major source of gravel while the river partially maintains its braided pattern. The Amblève River in the Belgian Ardennes uplands underwent less dramatic changes. Large parts of the catchment are deforested during the last 700 years, leading to an increase in floodplain sedimentation. Despite this major sediment pulse, change in floodplain morphology remained limited to an increase in bank height. We argue that a combination of floodplain and channel morphology, the fine texture of supplied sediment and the high stream power of channel forming events result is a system that is less sensitive to change. Also the relative short time of impact may play a role. These three examples demonstrate the varying impact of human deforestation on floodplain geomorphology. For the Dijle and Valdaine region this lead to dramatic changes once a certain tipping point is reached. In contrast the Amblève river is more resilient to human impact due to its specific morphological setting. The morphology of the catchments and the nature of supplied sediments plays a major role in the sensitivity of fluvial systems to environmental impact. Once the tipping points are reached, it is difficult for the river to revert to its original state and floodplains remain highly impacted.

First-Class State Change in Plaid

DTIC Science & Technology

2011-10-01

conceptual state change. State change is pervasive in the natural world; as a dramatic example, consider the state transition from egg, to caterpillar ...All this raises a natural question: why not support abstract states in programming languages? We previously proposed Typestate-Oriented Programming as...well as trait-like state composition. Plaid has been implemented, and has proven effective for writing a diverse set of small and medium- sized (up to

Science Curriculum in the Market Liberal Society of the Twenty-First Century: "Re-Visioning" the Idea of Science for All

ERIC Educational Resources Information Center

Smith, Dorothy V.; Gunstone, Richard F.

2009-01-01

The period since the 1960s has seen dramatic change in the nature and practice of science, science education and secondary school education itself. This paper examines changes in the Science for All movement, setting these changes in the context of the societal shift towards market liberalism and the advancement of a new style of individualism. We…

An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding

PubMed Central

Gordon, Kerry; Nesterovitch, Andrew B.; Lünsdorf, Heinrich; Chen, Zhenlong; Castellon, Maricela; Popova, Isolda A.; Kalinin, Sergey; Mendonca, Emma; Petukhov, Pavel A.; Schwartz, David E.

2011-01-01

Background Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases. Previously, a striking familial elevation in blood ACE was explained by mutations in the ACE juxtamembrane region that enhanced the cleavage-secretion process. Recently, we found a family whose affected members had a 6-fold increase in blood ACE and a Tyr465Asp (Y465D) substitution, distal to the stalk region, in the N domain of ACE. Methodology/Principal Findings HEK and CHO cells expressing mutant (Tyr465Asp) ACE demonstrate a 3- and 8-fold increase, respectively, in the rate of ACE shedding compared to wild-type ACE. Conformational fingerprinting of mutant ACE demonstrated dramatic changes in ACE conformation in several different epitopes of ACE. Cell ELISA carried out on CHO-ACE cells also demonstrated significant changes in local ACE conformation, particularly proximal to the stalk region. However, the cleavage site of the mutant ACE - between Arg1203 and Ser1204 - was the same as that of WT ACE. The Y465D substitution is localized in the interface of the N-domain dimer (from the crystal structure) and abolishes a hydrogen bond between Tyr465 in one monomer and Asp462 in another. Conclusions/Significance The Y465D substitution results in dramatic increase in the rate of ACE shedding and is associated with significant local conformational changes in ACE. These changes could result in increased ACE dimerization and accessibility of the stalk region or the entire sACE, thus increasing the rate of cleavage by the putative ACE secretase (sheddase). PMID:21998728

From Teeth to Baleen and Raptorial to Bulk Filter Feeding in Mysticete Cetaceans: The Role of Paleontological, Genetic, and Geochemical Data in Feeding Evolution and Ecology.

PubMed

Berta, Annalisa; Lanzetti, Agnese; Ekdale, Eric G; Deméré, Thomas A

2016-12-01

The origin of baleen and filter feeding in mysticete cetaceans occurred sometime between approximately 34 and 24 million years ago and represents a major macroevolutionary shift in cetacean morphology (teeth to baleen) and ecology (raptorial to filter feeding). We explore this dramatic change in feeding strategy by employing a diversity of tools and approaches: morphology, molecules, development, and stable isotopes from the geological record. Adaptations for raptorial feeding in extinct toothed mysticetes provide the phylogenetic context for evaluating morphological apomorphies preserved in the skeletons of stem and crown edentulous mysticetes. In this light, the presence of novel vascular structures on the palates of certain Oligocene toothed mysticetes is interpreted as the earliest evidence of baleen and points to an intermediate condition between an ancestral condition with teeth only and a derived condition with baleen only. Supporting this step-wise evolutionary hypothesis, evidence from stable isotopes show how changes in dental chemistry in early toothed mysticetes tracked the changes in diet and environment. Recent discoveries also demonstrate how this transition was made possible by radical changes in cranial ontogeny. In addition, genetic mutations and the possession of dental pseudogenes in extant baleen whales support a toothed ancestry for mysticetes. Molecular and morphological data also document the dramatic developmental shifts that take place in extant fetal baleen whales, in skull development, resorption of a fetal dentition and growth of baleen. The mechanisms involved in this complex evolutionary transition that entails multiple, integrated aspects of anatomy and ecology are only beginning to be understood, and future work will further clarify the processes underlying this macroevolutionary pattern. © The Author 2016. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Understanding the Uncertainties in Consequences of Climate Change for the United States Power Sector Infrastructure when Considering a Realistic Mitigation Pace and Adaptation Needs.

NASA Astrophysics Data System (ADS)

Anderson, N. J.; Whiteford, E. J.; Jones, V.; Fritz, S. C.; Yang, H.; Appleby, P.; Bindler, R.

2014-12-01

In order to overcome the potential damages associated with climate change, a massive reduction in greenhouse gas emissions is necessary. Achieving these levels of emissions reductions will require dramatic changes in the U.S. electricity generating infrastructure: almost all of the fossil-generation fleet will need to be replaced with low-carbon sources and society would have to maintain a high build rate of new capacity for decades. Because the build rate of new electricity generating capacity may be limited, the timing of regulation is critical—the longer the U.S. waits to start reducing emissions, the faster the turnover in the electricity sector must occur in order to meet the same target. We investigate the relationship between climate policy timing and infrastructure turnover in the electricity sector. How long can we wait before constraints on infrastructure turnover in the electricity sector make achieving our climate goals impossible? We show that delaying climate change policy increases average construction rates by 25% to 85% and increases maximum construction rates by 50% to 300%. We also show that delaying climate policy has little effect on the age of retired plants or the stranded costs associated with premature retirement. We show that as we delay policy action, some goals won't be possible for attain. For example, unless we enable emissions reductions today, reducing cumulative emissions between now and 2040 by 50% when compared to a no-policy scenario is not possible.

[Local reactions after diphtheria-tetanus-acellular pertussis vaccines in mice; changes in histopathology at the injection site].

PubMed

Nagaoka, Chiharu; Katsuta, Tomohiro; Honjo, Ayako; Tateyama, Satoshi; Tokutake, Tadaomi; Arimoto, Yutaka; Nakajima, Natsuki; Goshima, Toshiro; Kato, Tatsuo

2006-03-01

Diphtheria-tetanus-acellular pertussis vaccine (DTaP) developed in Japan is now widely used worldwide. DTaP is safer than the diphtheria-tetanus-whole-cell pertussis vaccine (DTwP) and has fewer severe side effects, but local reactions such as redness, swelling, and induration are still reported. The pathophysiological mechanism of these reactions is controversial. To clarify the cause of local reactions, we conducted studies using the mouse model. After administering either one or two abdominal subcutaneous DTaP inoculations, we observed changes in histopathology at the injection site at 24h, 48h, and 7 days. The control group, inoculated with physiologic saline, showed no significant changes either pathologically or with the naked eye. All mice after DTaP vaccination showed indurations at the injection site. Pathologically, we watched leukocyte invasion into or around the site, especially neutrophils and eosinophils. After the first vaccination, the extent of the invasion was strong 24h and 7 days later. At 24h following the second vaccination, a dramatic leukocyte invasion seen persisted at 7days. At 7 days after the first vaccination, peripheral fibrosis had begun, and when a second vaccination was administered, it began even earlier at the second site. These histopathological changes show that local reactions are caused by both inflammatory and allergic responses. Because this mouse study resulted in the same pattern of reactions observed in humans, this method will be useful for studies focusing on local reactions.

Severe Bone Loss as Part of the Life History Strategy of Bowhead Whales

PubMed Central

George, John C.; Stimmelmayr, Raphaela; Suydam, Robert; Usip, Sharon; Givens, Geof; Sformo, Todd; Thewissen, J. G. M.

2016-01-01

The evolution of baleen constituted a major evolutionary change that made it possible for baleen whales to reach enormous body sizes while filter feeding on tiny organisms and migrating over tremendous distances. Bowhead whales (Balaena mysticetus) live in the Arctic where the annual cycle of increasing and decreasing ice cover affects their habitat, prey, and migration. During the nursing period, bowheads grow rapidly; but between weaning and approximately year 5, bowhead whales display sustained baleen and head growth while limiting growth in the rest of their bodies. During this period, they withdraw resources from the skeleton, in particular the ribs, which may lose 40% of bone mass. Such dramatic changes in bones of immature mammals are rare, although fossil cetaceans between 40 and 50 million years ago show an array of rib specializations that include bone loss and are usually interpreted as related to buoyancy control. PMID:27333180

Programmed cell death during development of cowpea (Vigna unguiculata (L.) Walp.) seed coat.

PubMed

Lima, Nathália Bastos; Trindade, Fernanda Gomes; da Cunha, Maura; Oliveira, Antônia Elenir Amâncio; Topping, Jennifer; Lindsey, Keith; Fernandes, Kátia Valevski Sales

2015-04-01

The seed coat develops primarily from maternal tissues and comprises multiple cell layers at maturity, providing a metabolically dynamic interface between the developing embryo and the environment during embryogenesis, dormancy and germination of seeds. Seed coat development involves dramatic cellular changes, and the aim of this research was to investigate the role of programmed cell death (PCD) events during the development of seed coats of cowpea [Vigna unguiculata (L.) Walp.]. We demonstrate that cells of the developing cowpea seed coats undergo a programme of autolytic cell death, detected as cellular morphological changes in nuclei, mitochondria, chloroplasts and vacuoles, DNA fragmentation and oligonucleosome accumulation in the cytoplasm, and loss of membrane viability. We show for the first time that classes 6 and 8 caspase-like enzymes are active during seed coat development, and that these activities may be compartmentalized by translocation between vacuoles and cytoplasm during PCD events. © 2014 John Wiley & Sons Ltd.

Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.

PubMed

Benedicto, Ignacio; Lehmann, Guillermo L; Ginsberg, Michael; Nolan, Daniel J; Bareja, Rohan; Elemento, Olivier; Salfati, Zelda; Alam, Nazia M; Prusky, Glen T; Llanos, Pierre; Rabbany, Sina Y; Maminishkis, Arvydas; Miller, Sheldon S; Rafii, Shahin; Rodriguez-Boulan, Enrique

2017-05-19

The outer blood-retina barrier is established through the coordinated terminal maturation of the retinal pigment epithelium (RPE), fenestrated choroid endothelial cells (ECs) and Bruch's membrane, a highly organized basement membrane that lies between both cell types. Here we study the contribution of choroid ECs to this process by comparing their gene expression profile before (P5) and after (P30) the critical postnatal period when mice acquire mature visual function. Transcriptome analyses show that expression of extracellular matrix-related genes changes dramatically over this period. Co-culture experiments support the existence of a novel regulatory pathway: ECs secrete factors that remodel RPE basement membrane, and integrin receptors sense these changes triggering Rho GTPase signals that modulate RPE tight junctions and enhance RPE barrier function. We anticipate our results will spawn a search for additional roles of choroid ECs in RPE physiology and disease.

Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors

PubMed Central

Benedicto, Ignacio; Lehmann, Guillermo L.; Ginsberg, Michael; Nolan, Daniel J.; Bareja, Rohan; Elemento, Olivier; Salfati, Zelda; Alam, Nazia M.; Prusky, Glen T.; Llanos, Pierre; Rabbany, Sina Y.; Maminishkis, Arvydas; Miller, Sheldon S.; Rafii, Shahin; Rodriguez-Boulan, Enrique

2017-01-01

The outer blood-retina barrier is established through the coordinated terminal maturation of the retinal pigment epithelium (RPE), fenestrated choroid endothelial cells (ECs) and Bruch's membrane, a highly organized basement membrane that lies between both cell types. Here we study the contribution of choroid ECs to this process by comparing their gene expression profile before (P5) and after (P30) the critical postnatal period when mice acquire mature visual function. Transcriptome analyses show that expression of extracellular matrix-related genes changes dramatically over this period. Co-culture experiments support the existence of a novel regulatory pathway: ECs secrete factors that remodel RPE basement membrane, and integrin receptors sense these changes triggering Rho GTPase signals that modulate RPE tight junctions and enhance RPE barrier function. We anticipate our results will spawn a search for additional roles of choroid ECs in RPE physiology and disease. PMID:28524846

Observed vulnerability of Filchner-Ronne Ice Shelf to wind-driven inflow of warm deep water.

PubMed

Darelius, E; Fer, I; Nicholls, K W

2016-08-02

The average rate of melting at the base of the large Filchner-Ronne Ice Shelf in the southern Weddell Sea is currently low, but projected to increase dramatically within the next century. In a model study, melt rates increase as changing ice conditions cause a redirection of a coastal current, bringing warm water of open ocean origin through the Filchner Depression and into the Filchner Ice Shelf cavity. Here we present observations from near Filchner Ice Shelf and from the Filchner Depression, which show that pulses of warm water already arrive as far south as the ice front. This southward heat transport follows the eastern flank of the Filchner Depression and is found to be directly linked to the strength of a wind-driven coastal current. Our observations emphasize the potential sensitivity of Filchner-Ronne Ice Shelf melt rates to changes in wind forcing.

Covalent functionalization of monolayered transition metal dichalcogenides by phase engineering.

PubMed

Voiry, Damien; Goswami, Anandarup; Kappera, Rajesh; e Silva, Cecilia de Carvalho Castro; Kaplan, Daniel; Fujita, Takeshi; Chen, Mingwei; Asefa, Tewodros; Chhowalla, Manish

2015-01-01

Chemical functionalization of low-dimensional materials such as nanotubes, nanowires and graphene leads to profound changes in their properties and is essential for solubilizing them in common solvents. Covalent attachment of functional groups is generally achieved at defect sites, which facilitate electron transfer. Here, we describe a simple and general method for covalent functionalization of two-dimensional transition metal dichalcogenide nanosheets (MoS₂, WS₂ and MoSe₂), which does not rely on defect engineering. The functionalization reaction is instead facilitated by electron transfer between the electron-rich metallic 1T phase and an organohalide reactant, resulting in functional groups that are covalently attached to the chalcogen atoms of the transition metal dichalcogenide. The attachment of functional groups leads to dramatic changes in the optoelectronic properties of the material. For example, we show that it renders the metallic 1T phase semiconducting, and gives it strong and tunable photoluminescence and gate modulation in field-effect transistors.

Biochemistry and Cell Wall Changes Associated with Noni (Morinda citrifolia L.) Fruit Ripening.

PubMed

Cárdenas-Coronel, Wendy G; Carrillo-López, Armando; Vélez de la Rocha, Rosabel; Labavitch, John M; Báez-Sañudo, Manuel A; Heredia, José B; Zazueta-Morales, José J; Vega-García, Misael O; Sañudo-Barajas, J Adriana

2016-01-13

Quality and compositional changes were determined in noni fruit harvested at five ripening stages, from dark-green to thaslucent-grayish. Fruit ripening was accompanied by acidity and soluble solids accumulation but pH diminution, whereas the softening profile presented three differential steps named early (no significant softening), intermediate (significant softening), and final (dramatic softening). At early step the extensive depolymerization of hydrosoluble pectins and the significantly increment of pectinase activities did not correlate with the slight reduction in firmness. The intermediate step showed an increment of pectinases and hemicellulases activities. The final step was accompanied by the most significant reduction in the yield of alcohol-insoluble solids as well as in the composition of uronic acids and neutral sugars; pectinases increased their activity and depolymerization of hemicellulosic fractions occurred. Noni ripening is a process conducted by the coordinated action of pectinases and hemicellulases that promote the differential dissasembly of cell wall polymers.

Statistical physics of the yielding transition in amorphous solids.

PubMed

Karmakar, Smarajit; Lerner, Edan; Procaccia, Itamar

2010-11-01

The art of making structural, polymeric, and metallic glasses is rapidly developing with many applications. A limitation is that under increasing external strain all amorphous solids (like their crystalline counterparts) have a finite yield stress which cannot be exceeded without effecting a plastic response which typically leads to mechanical failure. Understanding this is crucial for assessing the risk of failure of glassy materials under mechanical loads. Here we show that the statistics of the energy barriers ΔE that need to be surmounted changes from a probability distribution function that goes smoothly to zero as ΔE=0 to a pdf which is finite at ΔE=0 . This fundamental change implies a dramatic transition in the mechanical stability properties with respect to external strain. We derive exact results for the scaling exponents that characterize the magnitudes of average energy and stress drops in plastic events as a function of system size.

Figuring Out Gas in Galaxies In Enzo (FOGGIE): Resolving the Inner Circumgalactic Medium

NASA Astrophysics Data System (ADS)

Corlies, Lauren; Peeples, Molly; Tumlinson, Jason; O'Shea, Brian; Smith, Britton

2018-01-01

Cosmological hydrodynamical simulations using every common numerical method have struggled to reproduce the multiphase nature of the circumgalactic medium (CGM) revealed by recent observations. However, to date, resolution in these simulations has been aimed at dense regions — the galactic disk and in-falling satellites — while the diffuse CGM never reaches comparable levels of refinement. Taking advantage of the flexible grid structure of the adaptive mesh refinement code Enzo, we force refinement in a region of the CGM of a Milky Way-like galaxy to the same spatial resolution as that of the disk. In this talk, I will present how the physical and structural distributions of the circumgalactic gas change dramatically as a function of the resolution alone. I will also show the implications these changes have for the observational properties of the gas in the context of the observations.

Interference by the activated sludge matrix on the analysis of soluble microbial products in wastewater.

PubMed

Potvin, Christopher M; Zhou, Hongde

2011-11-01

The objective of this study was to demonstrate the effects of complex matrix effects caused by chemical materials on the analysis of key soluble microbial products (SMP) including proteins, humics, carbohydrates, and polysaccharides in activated sludge samples. Emphasis was placed on comparison of the commonly used standard curve technique with standard addition (SA), a technique that differs in that the analytical responses are measured for sample solutions spiked with known quantities of analytes. The results showed that using SA provided a great improvement in compensating for SMP recovery and thus improving measurement accuracy by correcting for matrix effects. Analyte recovery was found to be highly dependent on sample dilution, and changed due to extraction techniques, storage conditions and sample composition. Storage of sample extracts by freezing changed SMP concentrations dramatically, as did storage at 4°C for as little as 1d. Copyright © 2011 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pellicer-Porres, J., E-mail: Julio.Pellicer@uv.es; Segura, A.; Santamaría-Pérez, D.

We have measured high pressure α-quartz reflectance spectra in the mid infrared. We used single crystals, taking full profit of polarization. The quality of the spectra allows fitting the reflectance spectra. We have characterized the pressure evolution of E and A{sub 2} modes with increased precision, even in the spectral regions where they overlap. In addition, we have determined the TO-LO splitting of each mode. Some of the A{sub 2} modes show dramatic pressure variations of the LO-TO splitting, which cannot be explained only by changes in length and ionicity of individual bonds, requiring a new mechanism. We suggest thatmore » rotation of the SiO{sub 4} tetrahedra plays a fundamental role. We have also determined the evolution of the electronic dielectric constant under high pressure. We find that its pressure increment is mainly a volume effect, although the small increase in birefringence points to secondary changes associated to the electronic resonances.« less

Hemimetabolous genomes reveal molecular basis of termite eusociality.

PubMed

Harrison, Mark C; Jongepier, Evelien; Robertson, Hugh M; Arning, Nicolas; Bitard-Feildel, Tristan; Chao, Hsu; Childers, Christopher P; Dinh, Huyen; Doddapaneni, Harshavardhan; Dugan, Shannon; Gowin, Johannes; Greiner, Carolin; Han, Yi; Hu, Haofu; Hughes, Daniel S T; Huylmans, Ann-Kathrin; Kemena, Carsten; Kremer, Lukas P M; Lee, Sandra L; Lopez-Ezquerra, Alberto; Mallet, Ludovic; Monroy-Kuhn, Jose M; Moser, Annabell; Murali, Shwetha C; Muzny, Donna M; Otani, Saria; Piulachs, Maria-Dolors; Poelchau, Monica; Qu, Jiaxin; Schaub, Florentine; Wada-Katsumata, Ayako; Worley, Kim C; Xie, Qiaolin; Ylla, Guillem; Poulsen, Michael; Gibbs, Richard A; Schal, Coby; Richards, Stephen; Belles, Xavier; Korb, Judith; Bornberg-Bauer, Erich

2018-03-01

Around 150 million years ago, eusocial termites evolved from within the cockroaches, 50 million years before eusocial Hymenoptera, such as bees and ants, appeared. Here, we report the 2-Gb genome of the German cockroach, Blattella germanica, and the 1.3-Gb genome of the drywood termite Cryptotermes secundus. We show evolutionary signatures of termite eusociality by comparing the genomes and transcriptomes of three termites and the cockroach against the background of 16 other eusocial and non-eusocial insects. Dramatic adaptive changes in genes underlying the production and perception of pheromones confirm the importance of chemical communication in the termites. These are accompanied by major changes in gene regulation and the molecular evolution of caste determination. Many of these results parallel molecular mechanisms of eusocial evolution in Hymenoptera. However, the specific solutions are remarkably different, thus revealing a striking case of convergence in one of the major evolutionary transitions in biological complexity.

Investigating resonances above and below the threshold in nuclear reactions of astrophysical interest and beyond

DOE Office of Scientific and Technical Information (OSTI.GOV)

La Cognata, M., E-mail: lacognata@lns.infn.it; Kiss, G. G.; Mukhamedzhanov, A. M.

2015-10-15

Resonances in nuclear cross sections dramatically change their trends. Therefore, the presence of unexpected resonances might lead to unpredicted consequences on astrophysics and nuclear physics. In nuclear physics, resonances allow one to study states in the intermediate compound systems, to evaluate their cluster structure, for instance, especially in the energy regions approaching particle decay thresholds. In astrophysics, resonances might lead to changes in the nucleosynthesis flow, determining different isotopic compositions of the nuclear burning ashes. For these reasons, the Trojan Horse method has been modified to investigate resonant reactions. Thanks to this novel approach, for the first time normalization tomore » direct data might be avoided. Moreover, in the case of sub threshold resonances, the Trojan Horse method modified to investigate resonances allows one to deduce the asymptotic normalization coefficient, showing the close connection between the two indirect approaches.« less

Effects of developmental change in body size on ectotherm body temperature and behavioral thermoregulation: caterpillars in a heat-stressed environment.

PubMed

Nielsen, Matthew E; Papaj, Daniel R

2015-01-01

Ectotherms increase in size dramatically during development, and this growth should have substantial effects on their body temperature and ability to thermoregulate. To better understand how this change in size affects temperature, we examined the direct effects of body size on body temperature in Battus philenor caterpillars, and also how body size affects both the expression and effectiveness of thermal refuge-seeking, a thermoregulatory behavior. Field studies of both live caterpillars and physical operative temperature models indicated that caterpillar body temperature increases with body size. The operative temperature models also showed that thermal refuges have a greater cooling effect for larger caterpillars, while a laboratory study found that larger caterpillars seek refuges at a lower temperature. Although the details may vary, similar connections between developmental growth, temperature, and thermoregulation should be common among ectotherms and greatly affect both their development and thermal ecology.

Observed vulnerability of Filchner-Ronne Ice Shelf to wind-driven inflow of warm deep water

PubMed Central

Darelius, E.; Fer, I.; Nicholls, K. W.

2016-01-01

The average rate of melting at the base of the large Filchner-Ronne Ice Shelf in the southern Weddell Sea is currently low, but projected to increase dramatically within the next century. In a model study, melt rates increase as changing ice conditions cause a redirection of a coastal current, bringing warm water of open ocean origin through the Filchner Depression and into the Filchner Ice Shelf cavity. Here we present observations from near Filchner Ice Shelf and from the Filchner Depression, which show that pulses of warm water already arrive as far south as the ice front. This southward heat transport follows the eastern flank of the Filchner Depression and is found to be directly linked to the strength of a wind-driven coastal current. Our observations emphasize the potential sensitivity of Filchner-Ronne Ice Shelf melt rates to changes in wind forcing. PMID:27481659

Interspecies chemical communication in bacterial development.

PubMed

Straight, Paul D; Kolter, Roberto

2009-01-01

Our view of bacteria, from the earliest observations through the heyday of antibiotic discovery, has shifted dramatically. We recognize communities of bacteria as integral and functionally important components of diverse habitats, ranging from soil collectives to the human microbiome. To function as productive communities, bacteria coordinate metabolic functions, often requiring shifts in growth and development. The hallmark of cellular development, which we characterize as physiological change in response to environmental stimuli, is a defining feature of many bacterial interspecies interactions. Bacterial communities rely on chemical exchanges to provide the cues for developmental change. Traditional methods in microbiology focus on isolation and characterization of bacteria in monoculture, separating the organisms from the surroundings in which interspecies chemical communication has relevance. Developing multispecies experimental systems that incorporate knowledge of bacterial physiology and metabolism with insights from biodiversity and metagenomics shows great promise for understanding interspecies chemical communication in the microbial world.

Effects of bioleaching on the mechanical and chemical properties of waste rocks

NASA Astrophysics Data System (ADS)

Yin, Sheng-Hua; Wu, Ai-Xiang; Wang, Shao-Yong; Ai, Chun-Ming

2012-01-01

Bioleaching processes cause dramatic changes in the mechanical and chemical properties of waste rocks, and play an important role in metal recovery and dump stability. This study focused on the characteristics of waste rocks subjected to bioleaching. A series of experiments were conducted to investigate the evolution of rock properties during the bioleaching process. Mechanical behaviors of the leached waste rocks, such as failure patterns, normal stress, shear strength, and cohesion were determined through mechanical tests. The results of SEM imaging show considerable differences in the surface morphology of leached rocks located at different parts of the dump. The mineralogical content of the leached rocks reflects the extent of dissolution and precipitation during bioleaching. The dump porosity and rock size change under the effect of dissolution, precipitation, and clay transportation. The particle size of the leached rocks decreased due to the loss of rock integrity and the conversion of dry precipitation into fine particles.

Flooding and the framing of risk in British broadsheets, 1985-2010.

PubMed

Escobar, Maria Paula; Demeritt, David

2014-05-01

Our analysis of 2707 news stories explores the framing of flooding in Britain over the past quarter century and the displacement of a once dominant understanding of flooding as an agricultural problem of land drainage by the contemporary concern for its urban impacts, particularly to homes and property. We document dramatic changes in the volume and variety of reporting about flooding since 2000 as the risks of flooding have become more salient, the informal 'Gentlemen's Agreement' between government and private insurers has broken down, and flood management subjected to greater public scrutiny. While the historic reliance on private insurance remains largely unchallenged, we show that other aspects of flood hazard management are now topics of active political debate to which the looming threat of climate change adds both urgency and exculpatory excuses for poor performance. We conclude by reflecting on the significance of the case for grand theories of neoliberalisation and governmentality.

Elemental and mineralogical changes in soils due to bioturbation along an earthworm invasion chronosequence in northern Minnesota

Treesearch

Kathryn Resner; Kyungsoo Yoo; Cindy Hale; Anthony Aufdenkampe; Alex Blum; Stephen Sebestyen

2011-01-01

Minnesota forested soils have evolved without the presence of earthworms since the last glacial retreat. When exotic earthworms arrive, enhanced soil bioturbation often results in dramatic morphological and chemical changes in soils with negative implications for the forests' sustainability. However, the impacts of earthworm invasion on geochemical processes in...

Forest responses to changing climate: lessons from the past and uncertainty for the future

Treesearch

Donald H. DeHayes; George L., Jr. Jacobson; Paul G. Schaberg; Bruce Bongarten; Louis Iverson; Ann C. Dieffenbacher-Krall

2000-01-01

The earth's climate has undergone dramatic and long-term changes through natural processes many millennia before humans influenced global climate. Considerable evidence indicates that increasing concentrations of carbon dioxide and other greenhouse gases in the earth's atmosphere will lead to near-term warming, perhaps as much as 2 to 4°C in...

Southern forests: Yesterday, today, and tomorrow

Treesearch

R. Neil Sampson

2004-01-01

In the 20th century, southern forests changed dramatically. Those changes pale, however, when compared to what happened to the people of the region. In addition to growing over fourfold in numbers, the South's population has urbanized, globalized, and intellectualized in 100 years. Rural and isolated in the 19th century, they are today urban and cosmopolitan. One...

Influence of woodland expansion (1942 to 2000) on the establishment of Phytophthora ramorum

Treesearch

Ross K. Meentemeyer; Nathan E. Rank; Brian L. Anacker; David M. Rizzo; Hall J. Cushman

2008-01-01

Human land-use practices have resulted in dramatic alterations of forest ecosystems worldwide. By modifying transmission pathways and habitat structure, land use changes are being increasingly implicated in the emergence of infectious plant disease. In this research, we examined the effects of human-related land-cover change on the establishment of the invasive plant...