Power partial-discard strategy to obtain improved performance for simulated moving bed chromatography.

PubMed

Chung, Ji-Woo; Kim, Kyung-Min; Yoon, Tae-Ung; Kim, Seung-Ik; Jung, Tae-Sung; Han, Sang-Sup; Bae, Youn-Sang

2017-12-22

A novel power partial-discard (PPD) strategy was developed as a variant of the partial-discard (PD) operation to further improve the separation performance of the simulated moving bed (SMB) process. The PPD operation varied the flow rates of discard streams by introducing a new variable, the discard amount (DA) as well as varying the reported variable, discard length (DL), while the conventional PD used fixed discard flow rates. The PPD operations showed significantly improved purities in spite of losses in recoveries. Remarkably, the PPD operation could provide more enhanced purity for a given recovery or more enhanced recovery for a given purity than the PD operation. The two variables, DA and DL, in the PPD operation played a key role in achieving the desired purity and recovery. The PPD operations will be useful for attaining high-purity products with reasonable recoveries. Copyright © 2017 Elsevier B.V. All rights reserved.

Dynamic Coupling Between Respiratory and Cardiovascular System

NASA Astrophysics Data System (ADS)

Censi, Federica; Calcagnini, Giovanni; Cerutti, Sergio

The analysis of non-linear dynamics of the coupling among interacting quantities can be very useful for understanding the cardiorespiratory and cardiovascular control mechanisms. In this chapter RP is used to detect and quantify the degree of non-linear coupling between respiration and spontaneous rhythms of both heart rate and blood pressure variability signals. RQA turned out to be suitable for a quantitative evaluation of the observed coupling patterns among rhythms, both in simulated and real data, providing different degrees of coupling. The results from the simulated data showed that the increased degree of coupling between the signals was marked by the increase of PR and PD, and by the decrease of ER. When the RQA was applied to experimental data, PD and ER turned out to be the most significant variables, compared to PR. A remarkable finding is the detection of transient 1:2 PL episodes between respiration and cardiovascular variability signals. This phenomenon can be associated to a sub-harmonic synchronization between the two main rhythms of HR and BP variability series.

Phenotypic variability of Cat-Eye syndrome.

PubMed

Berends, M J; Tan-Sindhunata, G; Leegte, B; van Essen, A J

2001-01-01

Cat-Eye syndrome (CES) is a disorder with a variable pattern of multiple congenital anomalies of which coloboma of the iris and anal atresia are the best known. CES is cytogenetically characterised by the presence of an extra bisatellited marker chromosome, which represents an inverted dicentric duplication of a part of chromosome 22 (inv dup(22)). We report on three CES-patients who carry an inv dup(22) diagnosed with FISH studies. They show remarkable phenotypic variability. The cause of this variability is unknown. Furthermore, we review clinical features of 71 reported patients. Only 41% of the CES-patients have the combination of iris coloboma, anal anomalies and pre-auricular anomalies. Therefore, almost 60% of the CES-patients are hard to recognize by their phenotype alone. Mild to moderate mental retardation was found in 32% (16/50) of the cases. Mental retardation occurs more frequently in male CES-patients. There is no apparent phenotypic difference between mentally retarded and mentally normal CES-patients.

Analysis of the trade-off between high crop yield and low yield instability at the global scale

NASA Astrophysics Data System (ADS)

Ben-Ari, Tamara; Makowski, David

2016-10-01

Yield dynamics of major crops species vary remarkably among continents. Worldwide distribution of cropland influences both the expected levels and the interannual variability of global yields. An expansion of cultivated land in the most productive areas could theoretically increase global production, but also increase global yield instability if the most productive regions are characterized by high interannual yield variability. In this letter, we use portfolio analysis to quantify the tradeoff between the expected values and the interannual variance of global yield. We compute optimal frontiers for four crop species i.e., maize, rice, soybean and wheat and show how the distribution of cropland among large world regions can be optimized to either increase expected global crop production or decrease its interannual variability. We also show that a preferential allocation of cropland in the most productive regions can increase global expected yield at the expense of yield stability. Theoretically, optimizing the distribution of a small fraction of total cultivated areas can help find a good compromise between low instability and high crop yields at the global scale.

S193: another non-eclipsing SW Sex star

NASA Astrophysics Data System (ADS)

Martínez-Pais, I. G.; Rodríguez-Gil, P.; Casares, J.

1999-05-01

We present time-resolved optical spectroscopy of the cataclysmic variable S193. The emission lines are remarkably similar to those of V795 Her and exhibit high-velocity S-waves and complex absorptions that are modulated with the orbital period. Evidence for transient anomalous spectral features is seen during the first two nights of our run. We propose that S193 and V795 Her are non-eclipsing SW Sex stars. Finally, we show that the `disc overflow' model fails to explain the Balmer line orbital behaviour in these low-inclination systems.

Remarks on non-maximal integral elements of the Cartan plane in jet spaces

NASA Astrophysics Data System (ADS)

Bächtold, M.; Moreno, G.

2014-11-01

There is a natural filtration on the space of degree-k homogeneous polynomials in n independent variables with coefficients in the algebra of smooth functions on the Grassmannian Gr (n,s), determined by the tautological bundle. In this paper we show that the space of s-dimensional integral elements of a Cartan plane on J(E,n), with dimE=n+m, has an affine bundle structure modeled by the so-obtained bundles over Gr (n,s), and we study a natural distribution associated with it. As an example, we show that a third-order nonlinear PDE of Monge-Ampère type is not contact-equivalent to a quasi-linear one.

EGRET/COMPTEL Observations of an Unusual, Steep-Spectrum Gamma-Ray Source

NASA Technical Reports Server (NTRS)

Thompson, D. J.; Bertsch, D. L.; Hartman, R. C.; Collmar, W.; Johnson, W. N.

1999-01-01

During analysis of sources below the threshold of the third EGRET catalog, we have discovered a source, named GRO J1400-3956 based on the best position, with a remarkably steep spectrum. Archival analysis of COMPTEL data shows that the spectrum must have a strong turn-over in the energy range between COMPTEL and EGRET. The EGRET data show some evidence of time variability, suggesting an AGN, but the spectral change of slope is larger than that seen for most gamma-ray blazars. The sharp cutoff resembles the high-energy spectral breaks seen in some gamma-ray pulsars. There have as yet been no OSSE observations of this source.

Preeradication vaccine policy options for poliovirus infection and disease control.

PubMed

Thompson, Kimberly M; Pallansch, Mark A; Duintjer Tebbens, Radboud J; Wassilak, Steve G; Kim, Jong-Hoon; Cochi, Stephen L

2013-04-01

With the circulation of wild poliovirus (WPV) types 1 and 3 continuing more than a decade after the original goal of eradicating all three types of WPVs by 2000, policymakers consider many immunization options as they strive to stop transmission in the remaining endemic and outbreak areas and prevent reintroductions of live polioviruses into nonendemic areas. While polio vaccination choices may appear simple, our analysis of current options shows remarkable complexity. We offer important context for current and future polio vaccine decisions and policy analyses by developing decision trees that clearly identify potential options currently used by countries as they evaluate national polio vaccine choices. Based on a comprehensive review of the literature we (1) identify the current vaccination options that national health leaders consider for polio vaccination, (2) characterize current practices and factors that appear to influence national and international choices, and (3) assess the evidence of vaccine effectiveness considering sources of variability between countries and uncertainties associated with limitations of the data. With low numbers of cases occurring globally, the management of polio risks might seem like a relatively low priority, but stopping live poliovirus circulation requires making proactive and intentional choices to manage population immunity in the remaining endemic areas and to prevent reestablishment in nonendemic areas. Our analysis shows remarkable variability in the current national polio vaccine product choices and schedules, with combination vaccine options containing inactivated poliovirus vaccine and different formulations of oral poliovirus vaccine making choices increasingly difficult for national health leaders. © 2013 Society for Risk Analysis.

Clinical Trials With Large Numbers of Variables: Important Advantages of Canonical Analysis.

PubMed

Cleophas, Ton J

2016-01-01

Canonical analysis assesses the combined effects of a set of predictor variables on a set of outcome variables, but it is little used in clinical trials despite the omnipresence of multiple variables. The aim of this study was to assess the performance of canonical analysis as compared with traditional multivariate methods using multivariate analysis of covariance (MANCOVA). As an example, a simulated data file with 12 gene expression levels and 4 drug efficacy scores was used. The correlation coefficient between the 12 predictor and 4 outcome variables was 0.87 (P = 0.0001) meaning that 76% of the variability in the outcome variables was explained by the 12 covariates. Repeated testing after the removal of 5 unimportant predictor and 1 outcome variable produced virtually the same overall result. The MANCOVA identified identical unimportant variables, but it was unable to provide overall statistics. (1) Canonical analysis is remarkable, because it can handle many more variables than traditional multivariate methods such as MANCOVA can. (2) At the same time, it accounts for the relative importance of the separate variables, their interactions and differences in units. (3) Canonical analysis provides overall statistics of the effects of sets of variables, whereas traditional multivariate methods only provide the statistics of the separate variables. (4) Unlike other methods for combining the effects of multiple variables such as factor analysis/partial least squares, canonical analysis is scientifically entirely rigorous. (5) Limitations include that it is less flexible than factor analysis/partial least squares, because only 2 sets of variables are used and because multiple solutions instead of one is offered. We do hope that this article will stimulate clinical investigators to start using this remarkable method.

Shaping the Skin: The Interplay of Mesoscale Geometry and Corneocyte Swelling

NASA Astrophysics Data System (ADS)

Evans, Myfanwy E.; Roth, Roland

2014-01-01

The stratum corneum, the outer layer of mammalian skin, provides a remarkable barrier to the external environment, yet it has highly variable permeability properties where it actively mediates between inside and out. On prolonged exposure to water, swelling of the corneocytes (skin cells composed of keratin intermediate filaments) is the key process by which the stratum corneum controls permeability and mechanics. As for many biological systems with intricate function, the mesoscale geometry is optimized to provide functionality from basic physical principles. Here we show that a key mechanism of corneocyte swelling is the interplay of mesoscale geometry and thermodynamics: given helical tubes with woven geometry equivalent to the keratin intermediate filament arrangement, the balance of solvation free energy and elasticity induces swelling of the system, importantly with complete reversibility. Our result remarkably replicates macroscopic experimental data of native through to fully hydrated corneocytes. This finding not only highlights the importance of patterns and morphology in nature but also gives valuable insight into the functionality of skin.

Detailed analysis of the microbial population in Malaysian spontaneous cocoa pulp fermentations reveals a core and variable microbiota.

PubMed

Meersman, Esther; Steensels, Jan; Mathawan, Melissa; Wittocx, Pieter-Jan; Saels, Veerle; Struyf, Nore; Bernaert, Herwig; Vrancken, Gino; Verstrepen, Kevin J

2013-01-01

The fermentation of cocoa pulp is one of the few remaining large-scale spontaneous microbial processes in today's food industry. The microbiota involved in cocoa pulp fermentations is complex and variable, which leads to inconsistent production efficiency and cocoa quality. Despite intensive research in the field, a detailed and comprehensive analysis of the microbiota is still lacking, especially for the expanding Asian production region. Here, we report a large-scale, comprehensive analysis of four spontaneous Malaysian cocoa pulp fermentations across two time points in the harvest season and two fermentation methods. Our results show that the cocoa microbiota consists of a "core" and a "variable" part. The bacterial populations show a remarkable consistency, with only two dominant species, Lactobacillus fermentum and Acetobacter pasteurianus. The fungal diversity is much larger, with four dominant species occurring in all fermentations ("core" yeasts), and a large number of yeasts that only occur in lower numbers and specific fermentations ("variable" yeasts). Despite this diversity, a clear pattern emerges, with early dominance of apiculate yeasts and late dominance of Saccharomyces cerevisiae. Our results provide new insights into the microbial diversity in Malaysian cocoa pulp fermentations and pave the way for the selection of starter cultures to increase efficiency and consistency.

Long-term Internal Variability of the Tropical Pacific Atmosphere-Ocean System

NASA Astrophysics Data System (ADS)

Hadi Bordbar, Mohammad; Martin, Thomas; Park, Wonsun; Latif, Mojib

2016-04-01

The tropical Pacific has featured some remarkable trends during the recent decades such as an unprecedented strengthening of the Trade Winds, a strong cooling of sea surface temperatures (SST) in the eastern and central part, thereby slowing global warming and strengthening the zonal SST gradient, and highly asymmetric sea level trends with an accelerated rise relative to the global average in the western and a drop in the eastern part. These trends have been linked to an anomalously strong Pacific Walker Circulation, the major zonal atmospheric overturning cell in the tropical Pacific sector, but the origin of the strengthening is controversial. Here we address the question as to whether the recent decadal trends in the tropical Pacific atmosphere-ocean system are within the range of internal variability, as simulated in long unforced integrations of global climate models. We show that the recent trends are still within the range of long-term internal decadal variability. Further, such variability strengthens in response to enhanced greenhouse gas concentrations, which may further hinder detection of anthropogenic climate signals in that region.

THE COLOR VARIABILITY OF QUASARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmidt, Kasper B.; Rix, Hans-Walter; Knecht, Matthias

2012-01-10

We quantify quasar color variability using an unprecedented variability database-ugriz photometry of 9093 quasars from Sloan Digital Sky Survey (SDSS) Stripe 82, observed over 8 years at {approx}60 epochs each. We confirm previous reports that quasars become bluer when brightening. We find a redshift dependence of this blueing in a given set of bands (e.g., g and r), but show that it is the result of the flux contribution from less-variable or delayed emission lines in the different SDSS bands at different redshifts. After correcting for this effect, quasar color variability is remarkably uniform, and independent not only of redshift,more » but also of quasar luminosity and black hole mass. The color variations of individual quasars, as they vary in brightness on year timescales, are much more pronounced than the ranges in color seen in samples of quasars across many orders of magnitude in luminosity. This indicates distinct physical mechanisms behind quasar variability and the observed range of quasar luminosities at a given black hole mass-quasar variations cannot be explained by changes in the mean accretion rate. We do find some dependence of the color variability on the characteristics of the flux variations themselves, with fast, low-amplitude, brightness variations producing more color variability. The observed behavior could arise if quasar variability results from flares or ephemeral hot spots in an accretion disk.« less

Employees' Job Satisfaction: A Test of the Job Characteristics Model Among Social Work Practitioners.

PubMed

Blanz, Mathias

2017-01-01

The present article describes an investigation of the Job Characteristics Model (JCM) by Hackman and Oldham (1976) for the prediction of job satisfaction of employees in social work areas. While there is considerable evidence for the JCM with respect to profit-oriented organizations, it was tested whether it can also be applied to the non-profit sector. The present study surveyed 734 holders of jobs in social work in Germany in order to assess their job satisfaction and the core variables of the JCM (i.e., the five job characteristics and the three psychological states). Regression and mediation analyses were used to examine the relations between these variables. The results showed that the expected relations were remarkably in accordance with the findings from the for-profit sector. All model variables correlated positively with job satisfaction, with the psychological states showing higher coefficients than the job characteristics. In addition, the influence of job characteristics on job satisfaction was significantly mediated through the psychological states. These findings were supported by a replication study. Implications of the JCM for practice, in particular for assessment and interventions in social work organizations, are discussed.

Applying lessons from commercial aviation safety and operations to resuscitation.

PubMed

Ornato, Joseph P; Peberdy, Mary Ann

2014-02-01

Both commercial aviation and resuscitation are complex activities in which team members must respond to unexpected emergencies in a consistent, high quality manner. Lives are at stake in both activities and the two disciplines have similar leadership structures, standard setting processes, training methods, and operational tools. Commercial aviation crews operate with remarkable consistency and safety, while resuscitation team performance and outcomes are highly variable. This commentary provides the perspective of two physician-pilots showing how commercial aviation training, operations, and safety principles can be adapted to resuscitation team training and performance. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Unbinding slave spins in the Anderson impurity model

NASA Astrophysics Data System (ADS)

Guerci, Daniele; Fabrizio, Michele

2017-11-01

We show that a generic single-orbital Anderson impurity model, lacking, for instance, any kind of particle-hole symmetry, can be exactly mapped without any constraint onto a resonant level model coupled to two Ising variables, which reduce to one if the hybridization is particle-hole symmetric. The mean-field solution of this model is found to be stable to unphysical spontaneous magnetization of the impurity, unlike the saddle-point solution in the standard slave-boson representation. Remarkably, the mean-field estimate of the Wilson ratio approaches the exact value RW=2 in the Kondo regime.

Unification of the complex Langevin method and the Lefschetzthimble method

NASA Astrophysics Data System (ADS)

Nishimura, Jun; Shimasaki, Shinji

2018-03-01

Recently there has been remarkable progress in solving the sign problem, which occurs in investigating statistical systems with a complex weight. The two promising methods, the complex Langevin method and the Lefschetz thimble method, share the idea of complexifying the dynamical variables, but their relationship has not been clear. Here we propose a unified formulation, in which the sign problem is taken care of by both the Langevin dynamics and the holomorphic gradient flow. We apply our formulation to a simple model in three different ways and show that one of them interpolates the two methods by changing the flow time.

Complete mitochondrial genome of Xingguo red carp (Cyprinus carpio var. singuonensis) and purse red carp (Cyprinus carpio var. wuyuanensis).

PubMed

Hu, Guang-Fu; Liu, Xiang-Jiang; Li, Zhong; Liang, Hong-Wei; Hu, Shao-Na; Zou, Gui-Wei

2016-01-01

The complete mitochondrial genomes of Xingguo red carp (Cyprinus carpio var. singuonensis) and purse red carp (Cyprinus carpio var. wuyuanensis) were sequenced. Comparison of these two mitochondrial genomes revealed that the mtDNAs of these two common carp varieties were remarkably similar in genome length, gene order and content, and AT content. However, size variation between these two mitochondrial genomes presented here showed 39 site differences in overall length. About 2 site differences were located in rRNAs, 3 in tRNAs, 3 in the control region, 31 in protein-coding genes. Thirty-one variable bases in the protein-coding regions between the two varieties mitochondrial sequences led to three variable amino acids, which were mainly located in the protein ND5 and ND4.

Two complementary approaches to quantify variability in heat resistance of spores of Bacillus subtilis.

PubMed

den Besten, Heidy M W; Berendsen, Erwin M; Wells-Bennik, Marjon H J; Straatsma, Han; Zwietering, Marcel H

2017-07-17

Realistic prediction of microbial inactivation in food requires quantitative information on variability introduced by the microorganisms. Bacillus subtilis forms heat resistant spores and in this study the impact of strain variability on spore heat resistance was quantified using 20 strains. In addition, experimental variability was quantified by using technical replicates per heat treatment experiment, and reproduction variability was quantified by using two biologically independent spore crops for each strain that were heat treated on different days. The fourth-decimal reduction times and z-values were estimated by a one-step and two-step model fitting procedure. Grouping of the 20 B. subtilis strains into two statistically distinguishable groups could be confirmed based on their spore heat resistance. The reproduction variability was higher than experimental variability, but both variabilities were much lower than strain variability. The model fitting approach did not significantly affect the quantification of variability. Remarkably, when strain variability in spore heat resistance was quantified using only the strains producing low-level heat resistant spores, then this strain variability was comparable with the previously reported strain variability in heat resistance of vegetative cells of Listeria monocytogenes, although in a totally other temperature range. Strains that produced spores with high-level heat resistance showed similar temperature range for growth as strains that produced low-level heat resistance. Strain variability affected heat resistance of spores most, and therefore integration of this variability factor in modelling of spore heat resistance will make predictions more realistic. Copyright © 2017. Published by Elsevier B.V.

Physical Demand but Not Dexterity Is Associated with Motor Flexibility during Rapid Reaching in Healthy Young Adults

PubMed Central

Greve, Christian; Hortobàgyi, Tibor; Bongers, Raoul M.

2015-01-01

Healthy humans are able to place light and heavy objects in small and large target locations with remarkable accuracy. Here we examine how dexterity demand and physical demand affect flexibility in joint coordination and end-effector kinematics when healthy young adults perform an upper extremity reaching task. We manipulated dexterity demand by changing target size and physical demand by increasing external resistance to reaching. Uncontrolled manifold analysis was used to decompose variability in joint coordination patterns into variability stabilizing the end-effector and variability de-stabilizing the end-effector during reaching. Our results demonstrate a proportional increase in stabilizing and de-stabilizing variability without a change in the ratio of the two variability components as physical demands increase. We interpret this finding in the context of previous studies showing that sensorimotor noise increases with increasing physical demands. We propose that the larger de-stabilizing variability as a function of physical demand originated from larger sensorimotor noise in the neuromuscular system. The larger stabilizing variability with larger physical demands is a strategy employed by the neuromuscular system to counter the de-stabilizing variability so that performance stability is maintained. Our findings have practical implications for improving the effectiveness of movement therapy in a wide range of patient groups, maintaining upper extremity function in old adults, and for maximizing athletic performance. PMID:25970465

Euclidean distance can identify the mannitol level that produces the most remarkable integral effect on sugarcane micropropagation in temporary immersion bioreactors.

PubMed

Gómez, Daviel; Hernández, L Ázaro; Yabor, Lourdes; Beemster, Gerrit T S; Tebbe, Christoph C; Papenbrock, Jutta; Lorenzo, José Carlos

2018-03-15

Plant scientists usually record several indicators in their abiotic factor experiments. The common statistical management involves univariate analyses. Such analyses generally create a split picture of the effects of experimental treatments since each indicator is addressed independently. The Euclidean distance combined with the information of the control treatment could have potential as an integrating indicator. The Euclidean distance has demonstrated its usefulness in many scientific fields but, as far as we know, it has not yet been employed for plant experimental analyses. To exemplify the use of the Euclidean distance in this field, we performed an experiment focused on the effects of mannitol on sugarcane micropropagation in temporary immersion bioreactors. Five mannitol concentrations were compared: 0, 50, 100, 150 and 200 mM. As dependent variables we recorded shoot multiplication rate, fresh weight, and levels of aldehydes, chlorophylls, carotenoids and phenolics. The statistical protocol which we then carried out integrated all dependent variables to easily identify the mannitol concentration that produced the most remarkable integral effect. Results provided by the Euclidean distance demonstrate a gradually increasing distance from the control in function of increasing mannitol concentrations. 200 mM mannitol caused the most significant alteration of sugarcane biochemistry and physiology under the experimental conditions described here. This treatment showed the longest statistically significant Euclidean distance to the control treatment (2.38). In contrast, 50 and 100 mM mannitol showed the lowest Euclidean distances (0.61 and 0.84, respectively) and thus poor integrated effects of mannitol. The analysis shown here indicates that the use of the Euclidean distance can contribute to establishing a more integrated evaluation of the contrasting mannitol treatments.

The Remarkable 2003-2004 Winter and Other Recent Warm Winters in the Arctic Stratosphere Since the Late 1990s

NASA Technical Reports Server (NTRS)

Manney, Gloria L.; Krueger, Kirstin; Sabutis, Joseph L.; Sena, Sara Amina; Pawson, Steven

2004-01-01

The 2003-2004 Arctic winter was remarkable in the 40-year record of meteorological analyses. A major warming beginning in early January 2004 led to nearly two months of vortex disruption with high-latitude easterlies in the middle to lower stratosphere. The upper stratospheric vortex broke up in late December, but began to recover by early January, and in February and March was the strongest since regular observations began in 1979. The lower stratospheric vortex broke up in late January. Comparison with two previous years, 1984-1985 and 1986-1987, with prolonged mid-winter warming periods shows unique characteristics of the 2003-2004 warming period: The length of the vortex disruption, the strong and rapid recovery in the upper stratosphere, and the slow progression of the warming from upper to lower stratosphere. January 2004 zonal mean winds in the middle and lower stratosphere were over two standard deviations below average. Examination of past variability shows that the recent frequency of major stratospheric warmings (seven in the past six years) is unprecedented. Lower stratospheric temperatures were unusually high during six of the past seven years, with five having much lower than usual potential for PSC formation and ozone loss (nearly none in 1998-1999, 2001-2002 and 2003-2004, and very little in 1997-1998 and 2000-2001). Middle and upper stratospheric temperatures, however, were unusually low during and after February. The pattern of five of the last seven years with very low PSC potential would be expected to occur randomly once every approximately 850 years. This cluster of warm winters, immediately following a period of unusually cold winters, may have important implications for possible changes in interannual variability and for determination and attribution of trends in stratospheric temperatures and ozone.

The Remarkable 2003--2004 Winter and Other Recent Warm Winters in the Arctic Stratosphere Since the Late 1990s

NASA Technical Reports Server (NTRS)

Manney, Gloria L.; Kruger, Kirstin; Sabutis, Joseph L.; Sena, Sara Amina; Pawson, Steven

2005-01-01

The 2003-2004 Arctic winter was remarkable in the approximately 50-year record of meteorological analyses. A major warming beginning in early January 2004 led to nearly 2 months of vortex disruption with high-latitude easterlies in the middle to lower stratosphere. The upper stratospheric vortex broke up in late December, but began to recover by early January, and in February and March was the strongest since regular observations began in 1979. The lower stratospheric vortex broke up in late January. Comparison with 2 previous years, 1984-1985 and 1986-1987, with prolonged midwinter warming periods shows unique characteristics of the 2003-2004 warming period: The length of the vortex disruption, the strong and rapid recovery in the upper stratosphere, and the slow progression of the warming from upper to lower stratosphere. January 2004 zonal mean winds in the middle and lower stratosphere were over 2 standard deviations below average. Examination of past variability shows that the recent frequency of major stratospheric warmings (7 in the past 6 years) is unprecedented. Lower stratospheric temperatures were unusually high during 6 of the past 7 years, with 5 having much lower than usual potential for polar stratospheric cloud (PSC) formation and ozone loss (nearly none in 1998-1999, 2001-2002, and 2003-2004, and very little in 1997-1998 and 2000-2001). Middle and upper stratospheric temperatures, however, were unusually low during and after February. The pattern of 5 of the last 7 years with very low PSC potential would be expected to occur randomly once every 850 years. This cluster of warm winters, immediately following a period of unusually cold winters, may have important implications for possible changes in interannual variability and for determination and attribution of trends in stratospheric temperatures and ozone.

Preformulation studies and optimization of sodium alginate based floating drug delivery system for eradication of Helicobacter pylori.

PubMed

Diós, Péter; Nagy, Sándor; Pál, Szilárd; Pernecker, Tivadar; Kocsis, Béla; Budán, Ferenc; Horváth, Ildikó; Szigeti, Krisztián; Bölcskei, Kata; Máthé, Domokos; Dévay, Attila

2015-10-01

The aim of this study was to design a local, floating, mucoadhesive drug delivery system containing metronidazole for Helicobacter pylori eradication. Face-centered central composite design (with three factors, in three levels) was used for evaluation and optimization of in vitro floating and dissolution studies. Sodium alginate (X1), low substituted hydroxypropyl cellulose (L-HPC B1, X2) and sodium bicarbonate (X3) concentrations were the independent variables in the development of effervescent floating tablets. All tablets showed acceptable physicochemical properties. Statistical analysis revealed that tablets with 5.00% sodium alginate, 38.63% L-HPC B1 and 8.45% sodium bicarbonate content showed promising in vitro floating and dissolution properties for further examinations. Optimized floating tablets expressed remarkable floating force. Their in vitro dissolution studies were compared with two commercially available non-floating metronidazole products and then microbiologically detected dissolution, ex vivo detachment force, rheological mucoadhesion studies and compatibility studies were carried out. Remarkable similarity (f1, f2) between in vitro spectrophotometrically and microbiologically detected dissolutions was found. Studies revealed significant ex vivo mucoadhesion of optimized tablets, which was considerably increased by L-HPC. In vivo X-ray CT studies of optimized tablets showed 8h gastroretention in rats represented by an animation prepared by special CT technique. Copyright © 2015 Elsevier B.V. All rights reserved.

Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners

PubMed Central

Feinauer, Christoph; Procaccini, Andrea; Zecchina, Riccardo; Weigt, Martin; Pagnani, Andrea

2014-01-01

In the course of evolution, proteins show a remarkable conservation of their three-dimensional structure and their biological function, leading to strong evolutionary constraints on the sequence variability between homologous proteins. Our method aims at extracting such constraints from rapidly accumulating sequence data, and thereby at inferring protein structure and function from sequence information alone. Recently, global statistical inference methods (e.g. direct-coupling analysis, sparse inverse covariance estimation) have achieved a breakthrough towards this aim, and their predictions have been successfully implemented into tertiary and quaternary protein structure prediction methods. However, due to the discrete nature of the underlying variable (amino-acids), exact inference requires exponential time in the protein length, and efficient approximations are needed for practical applicability. Here we propose a very efficient multivariate Gaussian modeling approach as a variant of direct-coupling analysis: the discrete amino-acid variables are replaced by continuous Gaussian random variables. The resulting statistical inference problem is efficiently and exactly solvable. We show that the quality of inference is comparable or superior to the one achieved by mean-field approximations to inference with discrete variables, as done by direct-coupling analysis. This is true for (i) the prediction of residue-residue contacts in proteins, and (ii) the identification of protein-protein interaction partner in bacterial signal transduction. An implementation of our multivariate Gaussian approach is available at the website http://areeweb.polito.it/ricerca/cmp/code. PMID:24663061

On nonstationarity and antipersistency in global temperature series

NASA Astrophysics Data System (ADS)

KäRner, O.

2002-10-01

Statistical analysis is carried out for satellite-based global daily tropospheric and stratospheric temperature anomaly and solar irradiance data sets. Behavior of the series appears to be nonstationary with stationary daily increments. Estimating long-range dependence between the increments reveals a remarkable difference between the two temperature series. Global average tropospheric temperature anomaly behaves similarly to the solar irradiance anomaly. Their daily increments show antipersistency for scales longer than 2 months. The property points at a cumulative negative feedback in the Earth climate system governing the tropospheric variability during the last 22 years. The result emphasizes a dominating role of the solar irradiance variability in variations of the tropospheric temperature and gives no support to the theory of anthropogenic climate change. The global average stratospheric temperature anomaly proceeds like a 1-dim random walk at least up to 11 years, allowing good presentation by means of the autoregressive integrated moving average (ARIMA) models for monthly series.

Mass loss from interacting close binary systems

NASA Technical Reports Server (NTRS)

Plavec, M. J.

1981-01-01

The three well-defined classes of evolved binary systems that show evidence of present and/or past mass loss are the cataclysmic variables, the Algols, and Wolf-Rayet stars. It is thought that the transformation of supergiant binary systems into the very short-period cataclysmic variables must have been a complex process. The new evidence that has recently been obtained from the far ultraviolet spectra that a certain subclass of the Algols (the Serpentids) are undergoing fairly rapid evolution is discussed. It is thought probable that the remarkable mass outflow observed in them is connected with a strong wind powered by accretion. The origin of the circumbinary clouds or flat disks that probably surround many strongly interacting binaries is not clear. Attention is also given to binary systems with hot white dwarf or subdwarf components, such as the symbiotic objects and the BQ stars; it is noted that in them both components may be prone to an enhanced stellar wind.

An astrophysical interpretation of the remarkable g-mode frequency groups of the rapidly rotating γ Dor star, KIC 5608334

NASA Astrophysics Data System (ADS)

Saio, Hideyuki; Bedding, Timothy R.; Kurtz, Donald W.; Murphy, Simon J.; Antoci, Victoria; Shibahashi, Hiromoto; Li, Gang; Takata, Masao

2018-06-01

The Fourier spectrum of the γ-Dor variable KIC 5608334 shows remarkable frequency groups at ˜3, ˜6, ˜9, and 11-12 d-1. We explain the four frequency groups as prograde sectoral g modes in a rapidly rotating star. Frequencies of intermediate-to-high radial order prograde sectoral g modes in a rapidly rotating star are proportional to |m| (i.e. ν ∝ |m|) in the corotating frame as well as in the inertial frame. This property is consistent with the frequency groups of KIC 5608334 as well as the period versus period-spacing relation present within each frequency group, if we assume a rotation frequency of 2.2 d-1, and that each frequency group consists of prograde sectoral g modes of |m| = 1, 2, 3, and 4, respectively. In addition, these modes naturally satisfy near-resonance conditions νi ≈ νj + νk with mi = mj + mk. We even find exact resonance frequency conditions (within the precise measurement uncertainties) in many cases, which correspond to combination frequencies.

Improved brain and muscle mitochondrial respiration with CoQ. An in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies.

PubMed

Barbiroli, B; Iotti, S; Lodi, R

1999-01-01

We used in vivo phosphorus magnetic resonance spectroscopy (31P-MRS) to study the effect of CoQ10 on the efficiency of brain and skeletal muscle mitochondrial respiration in ten patients with mitochondrial cytopathies. Before CoQ, brain [PCr] was remarkably lower in patients than in controls, while [Pi] and [ADP] were higher. Brain cytosolic free [Mg2+] and delta G of ATP hydrolysis were also abnormal in all patients. MRS also revealed abnormal mitochondrial function in the skeletal muscles of all patients, as shown by a decreased rate of PCr recovery from exercise. After six-months of treatment with CoQ (150 mg/day), all brain MRS-measurable variables as well as the rate of muscle mitochondrial respiration were remarkably improved in all patients. These in vivo findings show that treatment with CoQ in patients with mitochondrial cytopathies improves mitochondrial respiration in both brain and skeletal muscles, and are consistent with Lenaz's view that increased CoQ concentration in the mitochondrial membrane increases the efficiency of oxidative phosphorylation independently of enzyme deficit.

High-Resolution Spectroscopy with the Chandra X-ray Observatory

ScienceCinema

Canizares, Claude R. [MIT, Cambridge, Massachusetts, United States

2017-12-09

The capabilities of the Chandra X-ray Observatory and XMM-Newton for high-resolution spectroscopy have brought tradition plasma diagnostic techniques to the study of cosmic plasma. Observations have probed nearly every class of astronomical object, from young proto-starts through massive O starts and black hole binaries, supernova remnants, active galactic nuclei, and the intergalactic medium. Many of these sources show remarkable rich spectra that reveal new physical information, such as emission measure distributions, elemental abundances, accretion disk and wind signatures, and time variability. This talk will present an overview of the Chandra instrumentaton and selected examples of spectral observations of astrophysical and cosmological importance.

Interacting with notebook input devices: an analysis of motor performance and users' expertise.

PubMed

Sutter, Christine; Ziefle, Martina

2005-01-01

In the present study the usability of two different types of notebook input devices was examined. The independent variables were input device (touchpad vs. mini-joystick) and user expertise (expert vs. novice state). There were 30 participants, of whom 15 were touchpad experts and the other 15 were mini-joystick experts. The experimental tasks were a point-click task (Experiment 1) and a point-drag-drop task (Experiment 2). Dependent variables were the time and accuracy of cursor control. To assess carryover effects, we had the participants complete both experiments, using not only the input device for which they were experts but also the device for which they were novices. Results showed the touchpad performance to be clearly superior to mini-joystick performance. Overall, experts showed better performance than did novices. The significant interaction of input device and expertise showed that the use of an unknown device is difficult, but only for touchpad experts, who were remarkably slower and less accurate when using a mini-joystick. Actual and potential applications of this research include an evaluation of current notebook input devices. The outcomes allow ergonomic guidelines to be derived for optimized usage and design of the mini-joystick and touchpad devices.

Metadynamics convergence law in a multidimensional system

NASA Astrophysics Data System (ADS)

Crespo, Yanier; Marinelli, Fabrizio; Pietrucci, Fabio; Laio, Alessandro

2010-05-01

Metadynamics is a powerful sampling technique that uses a nonequilibrium history-dependent process to reconstruct the free-energy surface as a function of the relevant collective variables s . In Bussi [Phys. Rev. Lett. 96, 090601 (2006)] it is proved that, in a Langevin process, metadynamics provides an unbiased estimate of the free energy F(s) . We here study the convergence properties of this approach in a multidimensional system, with a Hamiltonian depending on several variables. Specifically, we show that in a Monte Carlo metadynamics simulation of an Ising model the time average of the history-dependent potential converge to F(s) with the same law of an umbrella sampling performed in optimal conditions (i.e., with a bias exactly equal to the negative of the free energy). Remarkably, after a short transient, the error becomes approximately independent on the filling speed, showing that even in out-of-equilibrium conditions metadynamics allows recovering an accurate estimate of F(s) . These results have been obtained introducing a functional form of the history-dependent potential that avoids the onset of systematic errors near the boundaries of the free-energy landscape.

Metadynamics convergence law in a multidimensional system.

PubMed

Crespo, Yanier; Marinelli, Fabrizio; Pietrucci, Fabio; Laio, Alessandro

2010-05-01

Metadynamics is a powerful sampling technique that uses a nonequilibrium history-dependent process to reconstruct the free-energy surface as a function of the relevant collective variables s . In Bussi [Phys. Rev. Lett. 96, 090601 (2006)] it is proved that, in a Langevin process, metadynamics provides an unbiased estimate of the free energy F(s) . We here study the convergence properties of this approach in a multidimensional system, with a Hamiltonian depending on several variables. Specifically, we show that in a Monte Carlo metadynamics simulation of an Ising model the time average of the history-dependent potential converge to F(s) with the same law of an umbrella sampling performed in optimal conditions (i.e., with a bias exactly equal to the negative of the free energy). Remarkably, after a short transient, the error becomes approximately independent on the filling speed, showing that even in out-of-equilibrium conditions metadynamics allows recovering an accurate estimate of F(s) . These results have been obtained introducing a functional form of the history-dependent potential that avoids the onset of systematic errors near the boundaries of the free-energy landscape.

WEATHER ON OTHER WORLDS. III. A SURVEY FOR T DWARFS WITH HIGH-AMPLITUDE OPTICAL VARIABILITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heinze, Aren N.; Metchev, Stanimir; Kellogg, Kendra, E-mail: aren.heinze@stonybrook.edu, E-mail: smetchev@uwo.ca

2015-03-10

We have monitored 12 T dwarfs with the Kitt Peak 2.1 m telescope using an F814W filter (0.7-0.95 μm) to place in context the remarkable 10%-20% variability exhibited by the nearby T dwarf Luhman 16B in this wavelength regime. The motivation was the poorly known red optical behavior of T dwarfs, which have been monitored almost exclusively at infrared wavelengths, where variability amplitudes greater than 10% have been found to be very rare. We detect highly significant variability in two T dwarfs. The T2.5 dwarf 2MASS 13243559+6358284 shows consistent ∼17% variability on two consecutive nights. The T2 dwarf 2MASS J16291840+0335371 exhibits ∼10% variability thatmore » may evolve from night to night, similarly to Luhman 16B. Both objects were previously known to be variable in the infrared, but with considerably lower amplitudes. We also find evidence for variability in the T6 dwarf J162414.37+002915.6, but since it has lower significance, we conservatively refrain from claiming this object as a variable. We explore and rule out various telluric effects, demonstrating that the variations we detect are astrophysically real. We suggest that high-amplitude photometric variability for T dwarfs is likely more common in the red optical than at longer wavelengths. The two new members of the growing class of high-amplitude variable T dwarfs offer excellent prospects for further study of cloud structures and their evolution.« less

Interannual Variations in Earth's Low-Degree Gravity Field and the Connections With Geophysical/Climatic Changes

NASA Technical Reports Server (NTRS)

Chao, Benjamin F.; Cox, Christopher M.

2004-01-01

Long-wavelength time-variable gravity recently derived from satellite laser ranging (SLR) analysis have focused to a large extent on the effects of the recent (since 1998) large anomalous change in J2, or the Earth's oblateness, and the potential causes. However, it is relatively more difficult to determine whether there are corresponding signals in the shorter wavelength zonal harmonics from the existing SLR-derived time variable gravity results, although it appears that geophysical fluid mass transport is being observed. For example, the recovered J3 time series shows remarkable agreement with NCEP-derived estimates of atmospheric gravity variations. Likewise, some of the non-zonal spherical harmonic components have significant interannual signal that appears to be related to mass transport. The non-zonal degree-2 components show reasonable temporal correlation with atmospheric signals, as well as climatic effects such as El Nino Southern Oscillation. We will present recent updates on the J2 evolution, as well as a look at other low-degree components of the interannual variations of gravity, complete through degree 4. We will examine the possible geophysical and climatic causes of these low-degree time-variable gravity related to oceanic and hydrological mass transports, for example some anomalous but prominent signals found in the extratropic Pacific ocean related to the Pacific Decadal Oscillation.

Recent variations in geopotential height associated with West African monsoon variability

NASA Astrophysics Data System (ADS)

Okoro, Ugochukwu K.; Chen, Wen; Nath, Debashis

2018-02-01

In the present study, the atmospheric circulation patterns associated with the seasonal West Africa (WA) monsoon (WAM) rainfall variability has been investigated. The observational rainfall data from the Climatic Research Unit (CRU) and atmospheric fields from the National Center for Environmental Prediction (NCEP) reanalysis 2, from 1979 to 2014, have been used. The rainfall variability extremes, classified as wet or dry years, are the outcomes of simultaneous 6-month SPI at the three rainfall zones, which shows increasing trends [Guinea Coast (GC = 0.012 year-1), Eastern Sudano Sahel (ESS = 0.045 year-1) and Western Sudano Sahel (WSS = 0.056 year-1) from Sen's slope]; however, it is significant only in the Sahel region (α = 0.05 and α = 0.001 at ESS and WSS, respectively, from Mann-Kendall test). The vertical profile of the geopotential height (GpH) during the wet and dry years reveals that the 700 hPa anomalies show remarkable pattern at about 8°N to 13°N. This shows varying correlation with the zonal averaged vertically integrated moisture flux convergence and rainfall anomalies, respectively, as well as the oceanic pulsations indexes [Ocean Nino Index (ONI) and South Atlantic Ocean dipole index (SAODI), significant from t test], identified as precursors to the Sahel and GC rainfall variability respectively. The role of GpH anomalies at 700 hPa has been identified as the facilitator to the West African Westerly Jet's input to the moisture flux transported over the WA. This is a new perspective of the circulation processes associated with WAM and serves as a basis for modeling investigations.

Measures of Heart Rate Variability and How They Relate to Age, Gender, Emotional Behavior, and Academic Achievement in Elementary School Children in Adventist and Public Schools

ERIC Educational Resources Information Center

Dalton, Marilee Serns

2013-01-01

The analysis of heart rate variability (HRV) is one tool shown to be of value in examining heart-brain interactions. HRV is remarkably responsive to emotion, and the importance of emotional state in cognitive function is increasingly being recognized and socio-emotional learning strategies being utilized in the classroom. Consequently, the…

Dannie Heineman Prize for Mathematical Physics: Applying mathematical techniques to solve important problems in quantum theory

NASA Astrophysics Data System (ADS)

Bender, Carl

2017-01-01

The theory of complex variables is extremely useful because it helps to explain the mathematical behavior of functions of a real variable. Complex variable theory also provides insight into the nature of physical theories. For example, it provides a simple and beautiful picture of quantization and it explains the underlying reason for the divergence of perturbation theory. By using complex-variable methods one can generalize conventional Hermitian quantum theories into the complex domain. The result is a new class of parity-time-symmetric (PT-symmetric) theories whose remarkable physical properties have been studied and verified in many recent laboratory experiments.

Trajectory controllability of semilinear systems with multiple variable delays in control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klamka, Jerzy, E-mail: Jerzy.Klamka@polsl.pl, E-mail: Michal.Niezabitowski@polsl.pl; Niezabitowski, Michał, E-mail: Jerzy.Klamka@polsl.pl, E-mail: Michal.Niezabitowski@polsl.pl

In this paper, finite-dimensional dynamical control system described by semilinear differential state equation with multiple variable delays in control are considered. The concept of controllability we extend on trajectory controllability for systems with multiple point delays in control. Moreover, remarks and comments on the relationships between different concepts of controllability are presented. Finally, simple numerical example, which illustrates theoretical considerations is also given. The possible extensions are also proposed.

Clinical spectrum of anorexia nervosa in children.

PubMed

Atkins, D M; Silber, T J

1993-08-01

A retrospective review of 21 patients ages 12 years and younger (age of onset range 7 to 12 years) with anorexia nervosa showed diagnostic delay in the youngest ones, high incidence of family psychiatric history, a remarkable severity of illness, and positive response to intensive treatment. Additional findings included significant comorbidity, a distinct subgroup with personality disorder and another with features of the "vulnerable child syndrome." This broad clinical spectrum of anorexia nervosa in children may explain the great variability in outcome. The development of anorexia nervosa in children relates to a complex combination of etiological and trigger factors. Precipitants identified in this study were physical maturation, entry into junior high, loss, or some combination thereof.

Molecular-dynamics simulation of polymethylene chain confined in cylindrical potentials. I. Nature of the conformational defects

NASA Astrophysics Data System (ADS)

Yamamoto, Takashi; Kimikawa, Yuichi

1992-10-01

The conformational motion of a polymethylene molecule constrained by a cylindrical potential is simulated up to 100 ps. The molecule consists of 60 CH2 groups and has variable bond lengths, bond angles, and dihedral angles. Our main concern here is the excitation and the dynamics of the conformational defects: kinks, jogs, etc. Under weaker constraint a number of gauche bonds are excited; they mostly form pairs such as gtḡ kinks or gtttḡ jogs. These conformational defects show no continuous drift in space. Instead they often annihilate and then recreate at different sites showing apparently random positional changes. The conformational defects produce characteristic strain fields around them. It seems that the conformational defects interact attractively through these strain fields. This is evidenced by remarkably correlated spatial distributions of the gauche bonds.

Dynamic evolution of plant mitochondrial genomes: Mobile genes and introns and highly variable mutation rates

PubMed Central

Palmer, Jeffrey D.; Adams, Keith L.; Cho, Yangrae; Parkinson, Christopher L.; Qiu, Yin-Long; Song, Keming

2000-01-01

We summarize our recent studies showing that angiosperm mitochondrial (mt) genomes have experienced remarkably high rates of gene loss and concomitant transfer to the nucleus and of intron acquisition by horizontal transfer. Moreover, we find substantial lineage-specific variation in rates of these structural mutations and also point mutations. These findings mostly arise from a Southern blot survey of gene and intron distribution in 281 diverse angiosperms. These blots reveal numerous losses of mt ribosomal protein genes but, with one exception, only rare loss of respiratory genes. Some lineages of angiosperms have kept all of their mt ribosomal protein genes whereas others have lost most of them. These many losses appear to reflect remarkably high (and variable) rates of functional transfer of mt ribosomal protein genes to the nucleus in angiosperms. The recent transfer of cox2 to the nucleus in legumes provides both an example of interorganellar gene transfer in action and a starting point for discussion of the roles of mechanistic and selective forces in determining the distribution of genetic labor between organellar and nuclear genomes. Plant mt genomes also acquire sequences by horizontal transfer. A striking example of this is a homing group I intron in the mt cox1 gene. This extraordinarily invasive mobile element has probably been acquired over 1,000 times separately during angiosperm evolution via a recent wave of cross-species horizontal transfers. Finally, whereas all previously examined angiosperm mtDNAs have low rates of synonymous substitutions, mtDNAs of two distantly related angiosperms have highly accelerated substitution rates. PMID:10860957

Magneto-Structural Correlations in Pseudotetrahedral Forms of the [Co(SPh)4]2- Complex Probed by Magnetometry, MCD Spectroscopy, Advanced EPR Techniques, and ab Initio Electronic Structure Calculations.

PubMed

Suturina, Elizaveta A; Nehrkorn, Joscha; Zadrozny, Joseph M; Liu, Junjie; Atanasov, Mihail; Weyhermüller, Thomas; Maganas, Dimitrios; Hill, Stephen; Schnegg, Alexander; Bill, Eckhard; Long, Jeffrey R; Neese, Frank

2017-03-06

The magnetic properties of pseudotetrahedral Co(II) complexes spawned intense interest after (PPh 4 ) 2 [Co(SPh) 4 ] was shown to be the first mononuclear transition-metal complex displaying slow relaxation of the magnetization in the absence of a direct current magnetic field. However, there are differing reports on its fundamental magnetic spin Hamiltonian (SH) parameters, which arise from inherent experimental challenges in detecting large zero-field splittings. There are also remarkable changes in the SH parameters of [Co(SPh) 4 ] 2- upon structural variations, depending on the counterion and crystallization conditions. In this work, four complementary experimental techniques are utilized to unambiguously determine the SH parameters for two different salts of [Co(SPh) 4 ] 2- : (PPh 4 ) 2 [Co(SPh) 4 ] (1) and (NEt 4 ) 2 [Co(SPh) 4 ] (2). The characterization methods employed include multifield SQUID magnetometry, high-field/high-frequency electron paramagnetic resonance (HF-EPR), variable-field variable-temperature magnetic circular dichroism (VTVH-MCD), and frequency domain Fourier transform THz-EPR (FD-FT THz-EPR). Notably, the paramagnetic Co(II) complex [Co(SPh) 4 ] 2- shows strong axial magnetic anisotropy in 1, with D = -55(1) cm -1 and E/D = 0.00(3), but rhombic anisotropy is seen for 2, with D = +11(1) cm -1 and E/D = 0.18(3). Multireference ab initio CASSCF/NEVPT2 calculations enable interpretation of the remarkable variation of D and its dependence on the electronic structure and geometry.

Anonymous broadcasting of classical information with a continuous-variable topological quantum code

NASA Astrophysics Data System (ADS)

Menicucci, Nicolas C.; Baragiola, Ben Q.; Demarie, Tommaso F.; Brennen, Gavin K.

2018-03-01

Broadcasting information anonymously becomes more difficult as surveillance technology improves, but remarkably, quantum protocols exist that enable provably traceless broadcasting. The difficulty is making scalable entangled resource states that are robust to errors. We propose an anonymous broadcasting protocol that uses a continuous-variable surface-code state that can be produced using current technology. High squeezing enables large transmission bandwidth and strong anonymity, and the topological nature of the state enables local error mitigation.

AeroPropulsoServoElasticity: Dynamic Modeling of the Variable Cycle Propulsion System

NASA Technical Reports Server (NTRS)

Kopasakis, George

2012-01-01

This presentation was made at the 2012 Fundamental Aeronautics Program Technical Conference and it covers research work for the Dynamic Modeling of the Variable cycle Propulsion System that was done under the Supersonics Project, in the area of AeroPropulsoServoElasticity. The presentation covers the objective for the propulsion system dynamic modeling work, followed by the work that has been done so far to model the variable Cycle Engine, modeling of the inlet, the nozzle, the modeling that has been done to model the affects of flow distortion, and finally presenting some concluding remarks and future plans.

Stone tool analysis and human origins research: some advice from Uncle Screwtape.

PubMed

Shea, John J

2011-01-01

The production of purposefully fractured stone tools with functional, sharp cutting edges is a uniquely derived hominin adaptation. In the long history of life on earth, only hominins have adopted this remarkably expedient and broadly effective technological strategy. In the paleontological record, flaked stone tools are irrefutable proof that hominins were present at a particular place and time. Flaked stone tools are found in contexts ranging from the Arctic to equatorial rainforests and on every continent except Antarctica. Paleolithic stone tools show complex patterns of variability, suggesting that they have been subject to the variable selective pressures that have shaped so many other aspects of hominin behavior and morphology. There is every reason to expect that insights gained from studying stone tools should provide vital and important information about the course of human evolution. And yet, one senses that archeological analyses of Paleolithic stone tools are not making as much of a contribution as they could to the major issues in human origins research. Copyright © 2011 Wiley Periodicals, Inc.

[Spatial differentiation and impact factors of Yutian Oasis's soil surface salt based on GWR model].

PubMed

Yuan, Yu Yun; Wahap, Halik; Guan, Jing Yun; Lu, Long Hui; Zhang, Qin Qin

2016-10-01

In this paper, topsoil salinity data gathered from 24 sampling sites in the Yutian Oasis were used, nine different kinds of environmental variables closely related to soil salinity were selec-ted as influencing factors, then, the spatial distribution characteristics of topsoil salinity and spatial heterogeneity of influencing factors were analyzed by combining the spatial autocorrelation with traditional regression analysis and geographically weighted regression model. Results showed that the topsoil salinity in Yutian Oasis was not of random distribution but had strong spatial dependence, and the spatial autocorrelation index for topsoil salinity was 0.479. Groundwater salinity, groundwater depth, elevation and temperature were the main factors influencing topsoil salt accumulation in arid land oases and they were spatially heterogeneous. The nine selected environmental variables except soil pH had significant influences on topsoil salinity with spatial disparity. GWR model was superior to the OLS model on interpretation and estimation of spatial non-stationary data, also had a remarkable advantage in visualization of modeling parameters.

Can we detect oceanic biodiversity hotspots from space?

PubMed

De Monte, Silvia; Soccodato, Alice; Alvain, Séverine; d'Ovidio, Francesco

2013-10-01

Understanding the variability of marine biodiversity is a central issue in microbiology. Current observational programs are based on in situ studies, but their implementation at the global scale is particularly challenging, owing to the ocean extent, its temporal variability and the heterogeneity of the data sources on which compilations are built. Here, we explore the possibility of identifying phytoplanktonic biodiversity hotspots from satellite. We define a Shannon entropy index based on patchiness in ocean color bio-optical anomalies. This index provides a high resolution (1 degree) global coverage. It shows a relation to temperature and mid-latitude maxima in accordance with those previously evidenced in microbiological biodiversity model and observational studies. Regional maxima are in remarkable agreement with several known biodiversity hotspots for plankton organisms and even for higher levels of the marine trophic chain, as well as with some in situ planktonic biodiversity estimates (from Atlantic Meridional Transect cruise). These results encourage to explore marine biodiversity with a coordinated effort of the molecular, ecological and remote sensing communities.

Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols

PubMed Central

Shiwa, Yuh; Hachiya, Tsuyoshi; Furukawa, Ryohei; Ohmomo, Hideki; Ono, Kanako; Kudo, Hisaaki; Hata, Jun; Hozawa, Atsushi; Iwasaki, Motoki; Matsuda, Koichi; Minegishi, Naoko; Satoh, Mamoru; Tanno, Kozo; Yamaji, Taiki; Wakai, Kenji; Hitomi, Jiro; Kiyohara, Yutaka; Kubo, Michiaki; Tanaka, Hideo; Tsugane, Shoichiro; Yamamoto, Masayuki; Sobue, Kenji; Shimizu, Atsushi

2016-01-01

Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type composition variables. In Experiment 1, whole blood from 16 volunteers was collected to examine the effect of a 24 h storage period at 4°C on DNA methylation profiles as measured using the Infinium HumanMethylation450 BeadChip array. Our statistical analysis showed that the P-value distribution of more than 450,000 CpG sites was similar to the theoretical distribution (in quantile-quantile plot, λ = 1.03) when comparing two control replicates, which was remarkably deviated from the theoretical distribution (λ = 1.50) when comparing control and storage conditions. We then considered cell-type composition as a possible cause of the observed bias in DNA methylation profiles and found that the bias associated with the cold storage condition was largely decreased (λadjusted = 1.14) by taking into account a cell-type composition variable. As such, we compared four respective sample collection protocols used in large-scale Japanese biobanks or cohorts as well as two control replicates. Systematic biases in DNA methylation profiles were observed between control and three of four protocols without adjustment of cell-type composition (λ = 1.12–1.45) and no remarkable biases were seen after adjusting for cell-type composition in all four protocols (λadjusted = 1.00–1.17). These results revealed important implications for comparing DNA methylation profiles between blood specimens from different sources and may lead to discovery of disease-associated DNA methylation markers and the development of DNA methylation profile-based predictive risk models. PMID:26799745

Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.

PubMed

Shiwa, Yuh; Hachiya, Tsuyoshi; Furukawa, Ryohei; Ohmomo, Hideki; Ono, Kanako; Kudo, Hisaaki; Hata, Jun; Hozawa, Atsushi; Iwasaki, Motoki; Matsuda, Koichi; Minegishi, Naoko; Satoh, Mamoru; Tanno, Kozo; Yamaji, Taiki; Wakai, Kenji; Hitomi, Jiro; Kiyohara, Yutaka; Kubo, Michiaki; Tanaka, Hideo; Tsugane, Shoichiro; Yamamoto, Masayuki; Sobue, Kenji; Shimizu, Atsushi

2016-01-01

Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type composition variables. In Experiment 1, whole blood from 16 volunteers was collected to examine the effect of a 24 h storage period at 4°C on DNA methylation profiles as measured using the Infinium HumanMethylation450 BeadChip array. Our statistical analysis showed that the P-value distribution of more than 450,000 CpG sites was similar to the theoretical distribution (in quantile-quantile plot, λ = 1.03) when comparing two control replicates, which was remarkably deviated from the theoretical distribution (λ = 1.50) when comparing control and storage conditions. We then considered cell-type composition as a possible cause of the observed bias in DNA methylation profiles and found that the bias associated with the cold storage condition was largely decreased (λ adjusted = 1.14) by taking into account a cell-type composition variable. As such, we compared four respective sample collection protocols used in large-scale Japanese biobanks or cohorts as well as two control replicates. Systematic biases in DNA methylation profiles were observed between control and three of four protocols without adjustment of cell-type composition (λ = 1.12-1.45) and no remarkable biases were seen after adjusting for cell-type composition in all four protocols (λ adjusted = 1.00-1.17). These results revealed important implications for comparing DNA methylation profiles between blood specimens from different sources and may lead to discovery of disease-associated DNA methylation markers and the development of DNA methylation profile-based predictive risk models.

Local variability but landscape stability in coral reef communities following repeated hurricane impacts

USGS Publications Warehouse

Bythell, John C.; Hillis-Star, Zandy M; Rogers, Caroline S.

2000-01-01

Coral reef community structure has remained remarkably stable over a 10 yr period within a small protected marine area despite repeated hurricane impacts. Local community dynamics have been highly variable, however. Sites that were destroyed by disease in the 1970s are showing little or no recovery, while sites less than a kilometre away that were devastated by Hurricane Hugo in 1989 are recovering well. Strong coral recruitment has occurred in shallow, exposed areas that showed the greatest hurricane impacts, and these areas are now more species rich than in 1988, although coral cover has not reached pre-hurricane levels. Coral colony survivorship has been high throughout most of the study area. Partial mortality rates were elevated for several years following Hurricane Hugo, but significant whole coral-head mortality only occurred during periods with hurricane impacts and only at the most exposed sites. Overall, the coral community has proved resilient to closely repeated major hurricane impacts. From a single case study we cannot attribute this resilience to the relatively low level of human impacts, but grazing fish populations have apparently remained high enough to keep macroalgae in check despite the mass mortality of the herbivore Diadema antillarum in the 1980s.

Ex vivo study for the assessment of behavioral factor and gene polymorphisms in individual susceptibility to oxidative DNA damage metals-induced.

PubMed

Di Pietro, Angela; Baluce, Barbara; Visalli, Giuseppa; La Maestra, Sebastiano; Micale, Rosanna; Izzotti, Alberto

2011-06-01

Transition metals in fine particulate matter generated by combustion induce oxidative DNA damage and inflammation. However, there is remarkable inter-individual variability in susceptibility to these damages. To assess this variability, an ex vivo study was performed using lymphocytes of 47 Caucasian healthy subjects. Cell samples were exposed to a water solution of oil fly ash (OFA). This was formed by the distinctive transition metals vanadium, iron, and nickel. Oxidative DNA damage was evaluated by testing cell viability, intracellular ROS production and 8-oxo-dG. DNA fragmentation and DNA repair capacity were assessed by using the Alkaline-Halo assay. GSTM1, GSTT1, hOGG1, and C677T and A1298C MTHFR gene polymorphisms were tested. Demographic and behavioral factors, collected by questionnaire, were also considered. OFA induced damages showed: (a) a 20-fold variation in range among different subjects in ROS production, (b) a 7-fold variation in range of 8-oxo-dG, and (c) a 25-fold variation in range in DNA repair capacity. A significant increase in DNA damage was detected in GSTT1-deficent subjects compared with wild type genotype carriers. Increases in cytoplasmic ROS and decreases in DNA repair capacity (P<0.05) were observed in C677T and A1298C variants of MTHFR. A remarkable protective effect of high fruits and vegetable intake was observed for ROS production and DNA damage. Conversely, an adverse effect of meat intake was observed on ROS increase, DNA damage and repair capacity, probably due to the increased intake of bioavailable iron. Smoking decreased DNA repair capacity, while age increased OFA-induced DNA damage. The wide comparative analysis of the complex interactions network, between genetic and behavioral factors provides evidence of the remarkable role of several lifestyle factors. In comparison to genetic polymorphisms they seem to have a higher weight in determining individual susceptibility to the adverse effects of airborne pollutants as transition metals. Copyright © 2011 Elsevier GmbH. All rights reserved.

Linking hydrolytic activities to variables influencing a submerged membrane bioreactor (MBR) treating urban wastewater under real operating conditions.

PubMed

Gómez-Silván, C; Arévalo, J; Pérez, J; González-López, J; Rodelas, B

2013-01-01

The seasonal variation of the hydrolytic activities acid and alkaline phosphatase, α-glucosidase and protease, was studied in both the aerated and anoxic phases of a full-scale membrane bioreactor (MBR) (total operational volume = 28.2 m(3)), operated in pre-denitrification mode and fed real urban wastewater. Non-metric multidimensional scaling (MDS) and BIO-ENV analysis were used to study the distribution of enzyme activities in different seasons of the year (spring, summer and autumn) and unveil their relationships with changes in variables influencing the system (composition of influent wastewater, activated sludge temperature and biomass concentration in the bioreactors). The activities of all the tested hydrolases were remarkably dynamic, and each enzyme showed complex and diverse patterns of variation. Except in the summer season, the variables included in this study gave a good explanation of those patterns and displayed high and consistent correlations with them; however, markedly different correlation trends were found in each season, indicating dissimilar adaptation responses of the community to the influence of changing conditions. A consistent and highly negative correlation between protease and α-glucosidase was revealed in all the experiments. The variables included in this study showed contrary influences on these activities, suggesting an alternation of the major groups of carbon-degrading hydrolases in connection to changes in temperature and the availability and composition of nutrients in the different seasons. Sampling over a long period of time was required to adequately lay down the links between hydrolytic activities and the variables influencing the MBR system. These results highlight the complexity of the regulation of substrate degradation by the mixed microbial sludge communities under real operating conditions. Copyright © 2012 Elsevier Ltd. All rights reserved.

Straight as an arrow: humpback whales swim constant course tracks during long-distance migration

PubMed Central

Horton, Travis W.; Holdaway, Richard N.; Zerbini, Alexandre N.; Hauser, Nan; Garrigue, Claire; Andriolo, Artur; Clapham, Phillip J.

2011-01-01

Humpback whale seasonal migrations, spanning greater than 6500 km of open ocean, demonstrate remarkable navigational precision despite following spatially and temporally distinct migration routes. Satellite-monitored radio tag-derived humpback whale migration tracks in both the South Atlantic and South Pacific include constant course segments of greater than 200 km, each spanning several days of continuous movement. The whales studied here maintain these directed movements, often with better than 1° precision, despite the effects of variable sea-surface currents. Such remarkable directional precision is difficult to explain by established models of directional orientation, suggesting that alternative compass mechanisms should be explored. PMID:21508023

Straight as an arrow: humpback whales swim constant course tracks during long-distance migration.

PubMed

Horton, Travis W; Holdaway, Richard N; Zerbini, Alexandre N; Hauser, Nan; Garrigue, Claire; Andriolo, Artur; Clapham, Phillip J

2011-10-23

Humpback whale seasonal migrations, spanning greater than 6500 km of open ocean, demonstrate remarkable navigational precision despite following spatially and temporally distinct migration routes. Satellite-monitored radio tag-derived humpback whale migration tracks in both the South Atlantic and South Pacific include constant course segments of greater than 200 km, each spanning several days of continuous movement. The whales studied here maintain these directed movements, often with better than 1° precision, despite the effects of variable sea-surface currents. Such remarkable directional precision is difficult to explain by established models of directional orientation, suggesting that alternative compass mechanisms should be explored.

Quality by design: optimization of a liquid filled pH-responsive macroparticles using Draper-Lin composite design.

PubMed

Rafati, Hasan; Talebpour, Zahra; Adlnasab, Laleh; Ebrahimi, Samad Nejad

2009-07-01

In this study, pH responsive macroparticles incorporating peppermint oil (PO) were prepared using a simple emulsification/polymer precipitation technique. The formulations were examined for their properties and the desired quality was then achieved using a quality by design (QBD) approach. For this purpose, a Draper-Lin small composite design study was employed in order to investigate the effect of four independent variables, including the PO to water ratio, the concentration of pH sensitive polymer (hydroxypropyl methylcellulose phthalate), acid and plasticizer concentrations, on the encapsulation efficiency and PO loading. The analysis of variance showed that the polymer concentration was the most important variable on encapsulation efficiency (p < 0.05). The multiple regression analysis of the results led to equations that adequately described the influence of the independent variables on the selected responses. Furthermore, the desirability function was employed as an effective tool for transforming each response separately and encompassing all of these responses in an overall desirability function for global optimization of the encapsulation process. The optimized macroparticles were predicted to yield 93.4% encapsulation efficiency and 72.8% PO loading, which were remarkably close to the experimental values of 89.2% and 69.5%, consequently.

Interactive influence of the Atlantic and Pacific climates and their contribution to the multidecadal variations of global temperature and precipitation.

NASA Astrophysics Data System (ADS)

Barcikowska, M. J.; Knutson, T. R.; Zhang, R.

2016-12-01

This study investigates mechanisms and global-scale climate impacts of multidecadal climate variability. Here we show, using observations and CSIRO-Mk3.6.0 model control run, that multidecadal variability of the Atlantic Meridional Overturning Circulation (AMOC) may have a profound impact on the thermal- and hydro-climatic changes over the Pacific region. In our model-based analysis we propose a mechanism, which comprises a coupled ocean-atmosphere teleconnection, established through the atmospheric overturning circulation cell between the tropical North Atlantic and tropical Pacific. For example, warming SSTs over the tropical North Atlantic intensify local convection and reinforce subsidence, low-level divergence in the eastern tropical Pacific. This is also accompanied with an intensification of trade winds, cooling and drying anomalies in the tropical central-east Pacific. The derived multidecadal changes, associated with the AMOC, contribute remarkably to the global temperature and precipitation variations. This highlights its potential predictive value. Shown here results suggest a possibility that: 1) recently observed slowdown in global warming may partly originate from internal variability, 2) climate system may be undergoing a transition to a cold AMO phase which could prolong the global slowdown.

Interannual Variability of Sea Level in Tropical Pacific during 1993-2014

NASA Astrophysics Data System (ADS)

Zhu, X.; Greatbatch, R. J.; Claus, M.

2016-12-01

More than 40 years ago, sea level variability in the tropical Pacific was being studied using linear shallow water models driven by observed estimates of the surface wind stress. At that time, the only available sea level data was from the sparse tide gauge record. However, with the advent of satellite data, there has been a revolution in the available data coverage for sea level. Here, a linear model, consisting of the first five baroclinic normal modes, and driven by ERA-Interim monthly wind stress anomalies, is used to investigate interannual variability in tropical Pacific sea level as seen in satellite altimeter data. The model output is fitted to the altimeter data along the equator, in order to derive the vertical profile for the wind forcing, and showing that a signature from modes higher than mode six cannot be extracted from the altimeter data. It is shown that the model has considerable skill at capturing interannual sea level variability both on and off the equator. The correlation between modelled and satellite-derived sea level data exceeds 0.8 over a wide range of longitudes along the equator and readily captures the observed ENSO events. Overall, the combination of the first, second and third and fifth modes can provide a robust estimate of the interannual sea level variability, the second mode being the most dominant. A remarkable feature of both the model and the altimeter data is the presence of a pivot point in the western Pacific on the equator. We show that the westward displacement of the pivot point from the centre of the basin is partly a signature of the recharge/discharge mechanism but is also strongly influenced by the fact that most of the wind stress variance along the equator is found in the western part of the basin. We also show that the Sverdrup transport plays no role in the recharge/discharge mechanism in our model.

VizieR Online Data Catalog: Mira Variables in the OGLE Bulge fields (Groenewegen+, 2005)

NASA Astrophysics Data System (ADS)

Groenewegen, M. A. T.; Blommaert, J. A. D. L.

2005-07-01

Table 1 provides the results of the period analysis (up to 3 periods with error and amplitudes with error), and associated 2MASS and DENIS photometry. Table 2 provides the cross-correlation with other objects and special remarks. (4 data files).

Individual differences and time-varying features of modular brain architecture.

PubMed

Liao, Xuhong; Cao, Miao; Xia, Mingrui; He, Yong

2017-05-15

Recent studies have suggested that human brain functional networks are topologically organized into functionally specialized but inter-connected modules to facilitate efficient information processing and highly flexible cognitive function. However, these studies have mainly focused on group-level network modularity analyses using "static" functional connectivity approaches. How these extraordinary modular brain structures vary across individuals and spontaneously reconfigure over time remain largely unknown. Here, we employed multiband resting-state functional MRI data (N=105) from the Human Connectome Project and a graph-based modularity analysis to systematically investigate individual variability and dynamic properties in modular brain networks. We showed that the modular structures of brain networks dramatically vary across individuals, with higher modular variability primarily in the association cortex (e.g., fronto-parietal and attention systems) and lower variability in the primary systems. Moreover, brain regions spontaneously changed their module affiliations on a temporal scale of seconds, which cannot be simply attributable to head motion and sampling error. Interestingly, the spatial pattern of intra-subject dynamic modular variability largely overlapped with that of inter-subject modular variability, both of which were highly reproducible across repeated scanning sessions. Finally, the regions with remarkable individual/temporal modular variability were closely associated with network connectors and the number of cognitive components, suggesting a potential contribution to information integration and flexible cognitive function. Collectively, our findings highlight individual modular variability and the notable dynamic characteristics in large-scale brain networks, which enhance our understanding of the neural substrates underlying individual differences in a variety of cognition and behaviors. Copyright © 2017 Elsevier Inc. All rights reserved.

Long-times series of infrasonic records at open-vents volcanoes (Yasur volcano, Vanuatu, 2003-2014): the remarkable temporal stability of magma viscosity

NASA Astrophysics Data System (ADS)

Vergniolle, S.; Souty, V.; Zielinski, C.; Bani, P.; LE Pichon, A.; Lardy, M.; Millier, P.; Herry, P.; Todman, S.; Garaebiti, E.

2017-12-01

Open-vents volcanoes, often presenting series of Strombolian explosions of various intensity, are responding, although with a delay, to any changes in the degassing pattern, providing a quasi-direct route to processes at depth. Open-vents volcanoes display a persistent volcanic activity, although of variable intensity. Long-times series at open-vents volcanoes could therefore be key measurements to unravel physical processes at the origin of Strombolian explosions and be crucial for monitoring. Continuous infrasonic records can be used to estimate the gas volume expelled at the vent during explosions (bursting of a long slug). The gas volume of each explosion is deduced from a series of two successive integrations of acoustic pressure (monopole). Here we analysed more than 4 years of infrasonic records at Yasur volcano (Vanuatu), spanning between 2003 and 2014 and organised into 8 main quasi-continuous periods. The relationship between the gas volume of each explosion and its associated maximum positive acoustic pressure, a proxy for the inner gas overpressure at bursting, shows a remarkably stable trend over the 8 periods. Two main trends exists, one which covers the full range of acoustic pressures (called « strong explosions ») and the second which represents explosions with a large gas volume and mild acoustic pressure. The class of « strong explosions » clearly follows the model of Del Bello et al. (2012), which shows that the inner gas overpressure at bursting, here empirically measured by the maximum acoustic pressure, is proportional to the gas volume. Constrains on magma viscosity and conduit radius, are deduced from this trend and from the gas volume at the transition passive-active degassing. The remarkable stability of this trend over time suggests that 1) the magma viscosity is stable at the depth where gas overpressure is produced within the slug and 2) any potential changes in magma viscosity occur very close to the top of the magma column.

Acoustic communication at the water's edge: evolutionary insights from a mudskipper.

PubMed

Polgar, Gianluca; Malavasi, Stefano; Cipolato, Giacomo; Georgalas, Vyron; Clack, Jennifer A; Torricelli, Patrizia

2011-01-01

Coupled behavioural observations and acoustical recordings of aggressive dyadic contests showed that the mudskipper Periophthalmodon septemradiatus communicates acoustically while out of water. An analysis of intraspecific variability showed that specific acoustic components may act as tags for individual recognition, further supporting the sounds' communicative value. A correlative analysis amongst acoustical properties and video-acoustical recordings in slow-motion supported first hypotheses on the emission mechanism. Acoustic transmission through the wet exposed substrate was also discussed. These observations were used to support an "exaptation hypothesis", i.e. the maintenance of key adaptations during the first stages of water-to-land vertebrate eco-evolutionary transitions (based on eco-evolutionary and palaeontological considerations), through a comparative bioacoustic analysis of aquatic and semiterrestrial gobiid taxa. In fact, a remarkable similarity was found between mudskipper vocalisations and those emitted by gobioids and other soniferous benthonic fishes.

Multilayer shallow water models with locally variable number of layers and semi-implicit time discretization

NASA Astrophysics Data System (ADS)

Bonaventura, Luca; Fernández-Nieto, Enrique D.; Garres-Díaz, José; Narbona-Reina, Gladys

2018-07-01

We propose an extension of the discretization approaches for multilayer shallow water models, aimed at making them more flexible and efficient for realistic applications to coastal flows. A novel discretization approach is proposed, in which the number of vertical layers and their distribution are allowed to change in different regions of the computational domain. Furthermore, semi-implicit schemes are employed for the time discretization, leading to a significant efficiency improvement for subcritical regimes. We show that, in the typical regimes in which the application of multilayer shallow water models is justified, the resulting discretization does not introduce any major spurious feature and allows again to reduce substantially the computational cost in areas with complex bathymetry. As an example of the potential of the proposed technique, an application to a sediment transport problem is presented, showing a remarkable improvement with respect to standard discretization approaches.

Acoustic Communication at the Water's Edge: Evolutionary Insights from a Mudskipper

PubMed Central

Polgar, Gianluca; Malavasi, Stefano; Cipolato, Giacomo; Georgalas, Vyron; Clack, Jennifer A.; Torricelli, Patrizia

2011-01-01

Coupled behavioural observations and acoustical recordings of aggressive dyadic contests showed that the mudskipper Periophthalmodon septemradiatus communicates acoustically while out of water. An analysis of intraspecific variability showed that specific acoustic components may act as tags for individual recognition, further supporting the sounds' communicative value. A correlative analysis amongst acoustical properties and video-acoustical recordings in slow-motion supported first hypotheses on the emission mechanism. Acoustic transmission through the wet exposed substrate was also discussed. These observations were used to support an “exaptation hypothesis”, i.e. the maintenance of key adaptations during the first stages of water-to-land vertebrate eco-evolutionary transitions (based on eco-evolutionary and palaeontological considerations), through a comparative bioacoustic analysis of aquatic and semiterrestrial gobiid taxa. In fact, a remarkable similarity was found between mudskipper vocalisations and those emitted by gobioids and other soniferous benthonic fishes. PMID:21738663

Design and test of a 10kW ORC supersonic turbine generator

NASA Astrophysics Data System (ADS)

Seume, J. R.; Peters, M.; Kunte, H.

2017-03-01

Manufactures are searching for possibilities to increase the efficiency of combustion engines by using the remaining energy of the exhaust gas. One possibility to recover some of this thermal energy is an organic Rankine cycle (ORC). For such an ORC running with ethanol, the aerothermodynamic design and test of a supersonic axial, single stage impulse turbine generator unit is described. The blade design as well as the regulation by variable partial admission is shown. Additionally the mechanical design of the directly coupled turbine generator unit including the aerodynamic sealing and the test facility is presented. Finally the results of CFD-based computations are compared to the experimental measurements. The comparison shows a remarkably good agreement between the numerical computations and the test data.

Organics Captured from Comet Wild 2 by the Stardust Spacecraft

NASA Technical Reports Server (NTRS)

Sandford, Scott A.; Aleon, Jerome; Araki, Tohru; Bajt, Sasa; Baratta, Giuseppe A.; Borg, Janet; Brucato, John R.; Burchell, Mark J.; Busemann, Henner; Butterworth, Anna;

Coupled-oscillator theory of dispersion and Casimir-Polder interactions.

PubMed

Berman, P R; Ford, G W; Milonni, P W

2014-10-28

We address the question of the applicability of the argument theorem (of complex variable theory) to the calculation of two distinct energies: (i) the first-order dispersion interaction energy of two separated oscillators, when one of the oscillators is excited initially and (ii) the Casimir-Polder interaction of a ground-state quantum oscillator near a perfectly conducting plane. We show that the argument theorem can be used to obtain the generally accepted equation for the first-order dispersion interaction energy, which is oscillatory and varies as the inverse power of the separation r of the oscillators for separations much greater than an optical wavelength. However, for such separations, the interaction energy cannot be transformed into an integral over the positive imaginary axis. If the argument theorem is used incorrectly to relate the interaction energy to an integral over the positive imaginary axis, the interaction energy is non-oscillatory and varies as r(-4), a result found by several authors. Rather remarkably, this incorrect expression for the dispersion energy actually corresponds to the nonperturbative Casimir-Polder energy for a ground-state quantum oscillator near a perfectly conducting wall, as we show using the so-called "remarkable formula" for the free energy of an oscillator coupled to a heat bath [G. W. Ford, J. T. Lewis, and R. F. O'Connell, Phys. Rev. Lett. 55, 2273 (1985)]. A derivation of that formula from basic results of statistical mechanics and the independent oscillator model of a heat bath is presented.

Black Holes, Hidden Symmetry and Complete Integrability: Brief Review

NASA Astrophysics Data System (ADS)

Frolov, Valeri P.

This chapter contains a brief review of the remarkable properties of higher dimensional rotating black holes with the spherical topology of the horizon. We demonstrate that these properties are connected with and generated by a special geometrical object, the Principal Conformal Killing-Yano tensor (PCKYT). The most general solution, describing such black holes, Kerr-NUT-ADS metric, admits this structure. Moreover a solution of the Einstein Equations with (or without) a cosmological constant which possesses PCKYT is the Kerr-NUT-ADS metric. This object (PCKYT) is responsible for such remarkable properties of higher dimensional rotating black holes as: (i) complete integrability of geodesic equations and (ii) complete separation of variables of the important field equations.

Variable X-ray Emission from FU Orionis

NASA Astrophysics Data System (ADS)

Skinner, Steve L.; Guedel, M.; Briggs, K. R.; Lamzin, S. A.; Sokal, K. R.

2009-05-01

FU Orionis is the prototype of a small but remarkable class of pre-main sequence stars ('FUors') that have undergone large optical outbursts thought to be linked to episodic accretion. FU Ori increased in optical brightness by about 6 mag in 1936-37 and is still in slow decline. Because of their high accretion rates, FUors are good candidates for exploring potential effects of accretion on X-ray emission. A recently completed survey of FUors with XMM-Newton detected X-rays from FU Ori and V1735 Cyg. We present new results from a sensitive 99 ksec (1.15 day) follow-up X-ray observation of FU Ori with Chandra. The Chandra ACIS-S CCD spectrum confirms the presence of a cool plasma component (kT < 1 keV) viewed under moderate absorption and a much hotter component (kT > 3 keV), viewed under high absorption, in accord with previous XMM results. The uninterrupted Chandra light curve shows that the hot component is slowly variable on a timescale of one day, but no variability is detected in the cool component. The slow variability and high plasma temperature point to a magnetic origin for the hot component, but other mechanisms (including accretion) may be responsible for the cool non-variable component. We will discuss these new results in the context of what is known about FU Ori from previous observations, including XMM (Skinner et al. 2006, ApJ, 643, 995) and HST (Kravtsova et al. 2007, Ast. Ltrs., 33, 755).

X-ray Binaries in the Central Region of M31

NASA Astrophysics Data System (ADS)

Trudolyubov, Sergey P.; Priedhorsky, W. C.; Cordova, F. A.

2006-09-01

We present the results of the systematic survey of X-ray sources in the central region of M31 using the data of XMM-Newton observations. The spectral properties and variability of 124 bright X-ray sources were studied in detail. We found that more than 80% of sources observed in two or more observations show significant variability on the time scales of days to years. At least 50% of the sources in our sample are spectrally variable. The fraction of variable sources in our survey is much higher than previously reported from Chandra survey of M31, and is remarkably close to the fraction of variable sources found in M31 globular cluster X-ray source population. We present spectral distribution of M31 X-ray sources, based on the spectral fitting with a power law model. The distribution of spectral photon index has two main peaks at 1.8 and 2.3, and shows clear evolution with source luminosity. Based on the similarity of the properties of M31 X-ray sources and their Galactic counterparts, we expect most of X-ray sources in our sample to be accreting binary systems with neutron star and black hole primaries. Combining the results of X-ray analysis (X-ray spectra, hardness-luminosity diagrams and variability) with available data at other wavelengths, we explore the possibility of distinguishing between bright neutron star and black hole binary systems, and identify 7% and 25% of sources in our sample as a probable black hole and neutron star candidates. Finally, we compare the M31 X-ray source population to the source populations of normal galaxies of different morphological type. Support for this work was provided through NASA Grant NAG5-12390. Part of this work was done during a summer workshop ``Revealing Black Holes'' at the Aspen Center for Physics, S. T. is grateful to the Center for their hospitality.

Analysis of monthly variability of thermocline in the South China Sea

NASA Astrophysics Data System (ADS)

Peng, Hanbang; Pan, Aijun; Zheng, Quan'an; Hu, Jianyu

2018-03-01

This study analyzes monthly variability of thermocline and its mechanism in the South China Sea (SCS). The study is based on 51-year (1960-2010) monthly seawater temperature and surface wind stress data from Simple Ocean Data Assimilation (SODA), together with heat flux, precipitation and evaporation data from the National Centers for Environmental Prediction (NCEP), the National Oceanic and Atmospheric Administration (NOAA) and the Woods Hole Oceanographic Institution, respectively. The results reveal that the upper boundary depth ( Z up), lower boundary depth ( Z low), thickness (Δ Z) and intensity ( T z ) of thermocline in the SCS show remarkable monthly variability. Being averaged for the deep basin of SCS, Z up deepens gradually from May to the following January and then shoals from February to May, while Z low varies little throughout the whole year. Further diagnostics indicates that the monthly variability of Z up is mainly caused by the buoyancy flux and wind stress curl. Using a linear method, the impacts of the buoyancy flux and wind stress curl on Z up can be quantitatively distinguished. The results suggest that Z up tends to deepen about 4.6 m when the buoyancy flux increases by 1×10 -5 kg/(m•s 3), while it shoals about 2.5 m when the wind stress curl strengthens by 1×10 -7 N/m³.

Linking animal-borne video to accelerometers reveals prey capture variability.

PubMed

Watanabe, Yuuki Y; Takahashi, Akinori

2013-02-05

Understanding foraging is important in ecology, as it determines the energy gains and, ultimately, the fitness of animals. However, monitoring prey captures of individual animals is difficult. Direct observations using animal-borne videos have short recording periods, and indirect signals (e.g., stomach temperature) are never validated in the field. We took an integrated approach to monitor prey captures by a predator by deploying a video camera (lasting for 85 min) and two accelerometers (on the head and back, lasting for 50 h) on free-swimming Adélie penguins. The movies showed that penguins moved the heads rapidly to capture krill in midwater and fish (Pagothenia borchgrevinki) underneath the sea ice. Captures were remarkably fast (two krill per second in swarms) and efficient (244 krill or 33 P. borchgrevinki in 78-89 min). Prey captures were detected by the signal of head acceleration relative to body acceleration with high sensitivity and specificity (0.83-0.90), as shown by receiver-operating characteristic analysis. Extension of signal analysis to the entire behavioral records showed that krill captures were spatially and temporally more variable than P. borchgrevinki captures. Notably, the frequency distribution of krill capture rate closely followed a power-law model, indicating that the foraging success of penguins depends on a small number of very successful dives. The three steps illustrated here (i.e., video observations, linking video to behavioral signals, and extension of signal analysis) are unique approaches to understanding the spatial and temporal variability of ecologically important events such as foraging.

Variability of CO2 concentrations and fluxes in and above an urban street canyon

NASA Astrophysics Data System (ADS)

Lietzke, Björn; Vogt, Roland

2013-08-01

The variability of CO2 concentrations and fluxes in dense urban environments is high due to the inherent heterogeneity of these complex areas and their spatio-temporally variable anthropogenic sources. With a focus on micro- to local-scale CO2-exchange processes, measurements were conducted in a street canyon in the city of Basel, Switzerland in 2010. CO2 fluxes were sampled at the top of the canyon (19 m) and at 39 m while vertical CO2 concentration profiles were measured in the center and at a wall of the canyon. CO2 concentration distributions in the street canyon and exchange processes with the layers above show, apart from expected general diurnal patterns due mixing layer heights, a strong dependence on wind direction relative to the canyon. As a consequence of the resulting corkscrew-like canyon vortex, accumulation of CO2 inside the canyon is modulated with distinct distribution patterns. The evaluation of diurnal traffic data provides good explanations for the vertical and horizontal differences in CO2-distribution inside the canyon. Diurnal flux characteristics at the top of the canyon can almost solely be explained with traffic density expressed by the strong linear dependence. Even the diurnal course of the flux at 39 m shows a remarkable relationship to traffic density for east wind conditions while, for west wind situations, a change toward source areas with lower emissions leads to a reduced flux.

Gravity receptor function in mice with graded otoconial deficiencies.

PubMed

Jones, Sherri M; Erway, Lawrence C; Johnson, Kenneth R; Yu, Heping; Jones, Timothy A

2004-05-01

The purpose of the present study was to examine gravity receptor function in mutant mouse strains with variable deficits in otoconia: lethal milk (lm), pallid (pa), tilted (tlt), mocha (mh), and muted (mu). Control animals were either age-matched heterozygotes or C57BL/6J (abbr. B6) mice. Gravity receptor function was measured using linear vestibular evoked potentials (VsEPs). Cage and swimming behaviors were also documented. Temporal bones were cleared to assess the overall otoconial deficit and to correlate structure and function for lm mice. Results confirmed the absence of VsEPs for mice that lacked otoconia completely. VsEP thresholds and amplitudes varied in mouse strains with variable loss of otoconia. Some heterozygotes also showed elevated VsEP thresholds in comparison to B6 mice. In lm mice, which have absent otoconia in the utricle and a variable loss of otoconia in the saccule, VsEPs were present and average P1/N1 amplitudes were highly correlated with the average loss of saccular otoconia (R = 0.77,p < 0.001). Cage and swimming behavior were not adversely affected in those animals with recordable VsEPs. Most, but not all, mice with absent VsEPs were unable to swim. Some animals were able to swim despite having no measurable gravity receptor response. The latter finding underscores the remarkable adaptive potential exhibited by neurobehavioral systems following profound sensory loss. It also shows that behavior alone may be an unreliable indicator of the extent of gravity receptor deficits.

Evaluation of long term solar activity effects on GPS derived TEC

NASA Astrophysics Data System (ADS)

Mansoori, Azad A.; Khan, Parvaiz A.; Ahmad, Rafi; Atulkar, Roshni; M, Aslam A.; Bhardwaj, Shivangi; Malvi, Bhupendra; Purohit, P. K.; Gwal, A. K.

2016-10-01

The solar activity hence the solar radiance follows a long term periodic variability with eleven years periodicity, known as solar cycle. This drives the long term variability of the ionosphere. In the present problem we investigate the long term behaviour of the ionosphere with the eleven year cyclic solar activity. Under the present study we characterize the ionospheric variability by Total Electron Content (TEC) using measurements made by Global Positioning System (GPS) and solar cycle variability by various solar activity indices. We make use of five solar activity indices viz. sunspot number (Rz), solar radio Flux (F10.7 cm), EUV Flux (26-34 nm), flare index and CME occurrences. The long term variability of these solar activity indices were then compared and correlated with the variability of ionospheric TEC, at a mid latitude station, Usuda (36.13N, 138.36E), of Japan, during the solar cycle 23 and ascending phase of cycle 24. From our study, we found that long term changes in the ionospheric TEC vary synchronously with corresponding changes in the solar activity indices. The correlation analysis shows that all the solar activity indices exhibit a very strong correlation with TEC (R =0.76 -0.99). Moreover the correlation between the two is stronger in the descending phase of the solar cycle. The correlation is found to be remarkably strongest during the deep minimum of the solar cycle 24 i.e. between 2007- 2009. Also we noticed a hysteresis effect exists with solar radio flux (F10.7 cm) and solar EUV flux (26-34 nm). This effect is absent with other parameters.

Teaching through Trade Books: 3-2-1 Blast Off

ERIC Educational Resources Information Center

Royce, Christine Anne

2013-01-01

In a remarkably brief period of time, humans have developed technology that allows space travel to become a reality. Rockets have been built, energy systems designed, and planetary forces understood. In the activities described in this article, students investigate space travel by designing their own rockets and manipulating variables to determine…

Learning to Look: Probabilistic Variation and Noise Guide Infants' Eye Movements

ERIC Educational Resources Information Center

Tummeltshammer, Kristen Swan; Kirkham, Natasha Z.

2013-01-01

Young infants have demonstrated a remarkable sensitivity to probabilistic relations among visual features (Fiser & Aslin, 2002; Kirkham et al., 2002). Previous research has raised important questions regarding the usefulness of statistical learning in an environment filled with variability and noise, such as an infant's natural world. In…

The Psychological World of the Gay Teenager: Social Change, Narrative, and "Normality"

ERIC Educational Resources Information Center

Cohler, Bertram J.; Hammack, Phillip L.

2007-01-01

This paper examines the application of concepts of normal adolescence pioneered by Offer and colleagues to the study of gay and lesbian youth. Adolescent development among this population demonstrates remarkable historical variability along the lines of generation-cohort, revealing the utility of a life-course approach to the study of normal…

Effect of Wind Flow on Convective Heat Losses from Scheffler Solar Concentrator Receivers

NASA Astrophysics Data System (ADS)

Nene, Anita Arvind; Ramachandran, S.; Suyambazhahan, S.

2018-05-01

Receiver is an important element of solar concentrator system. In a Scheffler concentrator, solar rays get concentrated at focus of parabolic dish. While radiation losses are more predictable and calculable since strongly related to receiver temperature, convective looses are difficult to estimate in view of additional factors such as wind flow direction, speed, receiver geometry, prior to current work. Experimental investigation was carried out on two geometries of receiver namely cylindrical and conical with 2.7 m2 Scheffler to find optimum condition of tilt to provide best efficiency. Experimental results showed that as compared to cylindrical receiver, conical receiver gave maximum efficiency at 45° tilt angle. However effect of additional factors like wind speed, wind direction on especially convective losses could not be separately seen. The current work was undertaken to investigate further the same two geometries using computation fluid dynamics using FLUENT to compute convective losses considering all variables such at tilt angle of receiver, wind velocity and wind direction. For cylindrical receiver, directional heat transfer coefficient (HTC) is remarkably high to tilt condition meaning this geometry is critical to tilt leading to higher convective heat losses. For conical receiver, directional average HTC is remarkably less to tilt condition leading to lower convective heat loss.

Temporal variability of submarine groundwater discharge: Assessments via radon and seep meters, the southern carmel coast, Israel

USGS Publications Warehouse

Weinstein, Y.; Shalem, Y.; Burnett, W.C.; Swarzenski, P.W.; Herut, B.

2007-01-01

Seep meter data from Dor Bay, Israel, showed a steady decrease in submarine groundwater discharge (SGD) rates between March and July 2006 (averages of 34, 10.4 and 1.5 cm d-1 in March, May and July, respectively), while estimates based on radon time series showed remarkably uniform averages (8 cm d-1). The May seep meter data show a rough positive correlation with sea level, unlike the negative correlation shown by the Rn-calculated rates. Smaller-size meters, deployed in July adjacent to the regular-size ones, showed significantly higher rates (10 cm d-1), which negatively correlated with salinity. It is suggested that the decreased rates documented by the seep meters are the result of an increased shallow seawater recharge in the bay (due to decreasing hydraulic gradients). This is not captured by the radon, since recharging water is radon-poor. The positive correlation of discharge with sea level is due to increased seawater recycling in times of high sea stand. Copyright ?? 2007 IAHS Press.

Functional Entropy Variables: A New Methodology for Deriving Thermodynamically Consistent Algorithms for Complex Fluids, with Particular Reference to the Isothermal Navier-Stokes-Korteweg Equations

DTIC Science & Technology

2012-11-01

multicorrector algorithm . Predictor stage: Set Cρn+1,(0) = C ρ n, (157) Cun+1,(0) = C u n, (158) Cvn+1,(0) = C v n. (159) Multicorrector stage: Repeat the... corrector algorithm given by (157)-(178). Remark 20. We adopt the preconditioned GMRES algorithm [53] from PETSc [2] to solve the linear system given by (175...ICES REPORT 12-43 November 2012 Functional Entropy Variables: A New Methodology for Deriving Thermodynamically Consistent Algorithms for Complex

Millennial-scale variability to 735 ka: High-resolution climate records from Santa Barbara Basin, CA

NASA Astrophysics Data System (ADS)

White, Sarah M.; Hill, Tessa M.; Kennett, James P.; Behl, Richard J.; Nicholson, Craig

2013-06-01

Determining the ultimate cause and effect of millennial-scale climate variability remains an outstanding problem in paleoceanography, partly due to the lack of high-resolution records predating the last glaciation. Recent cores from Santa Barbara Basin provide 2500-5700 year "windows" of climate with 10-50 year resolution. Ages for three cores, determined by seismic stratigraphic correlation, oxygen isotope stratigraphy, and biostratigraphy, date to 293 ka (MIS 8), 450 ka (MIS 12), and 735 ka (MIS 18). These records sample the Late Pleistocene, during which the 100 kyr cycle strengthened and the magnitude of glacial-interglacial cyclicity increased. Thus, these records provide a test of the dependence of millennial-scale behavior on variations in glacial-interglacial cyclicity. The stable isotopic (δ18O) composition of planktonic foraminifera shows millennial-scale variability in all three intervals, with similar characteristics (duration, cyclicity) to those previously documented during MIS 3 at this site. Stadial G. bulloides δ18O values are 2.75-1.75‰ (average 2.25‰) and interstadial values are 1.75-0.5‰ (average 1‰), with rapid (decadal-scale) interstadial and stadial initiations of 1-2‰, as in MIS 3. Interstadials lasted 250-1600 years and occurred every 650-1900 years. Stadial paleotemperatures were 3.5-9.5°C and interstadial paleotemperatures were 7.5-13°C. Upwelling, evidenced by planktonic foraminiferal assemblages and δ13C, increased during interstadials, similar to MIS 3; high productivity during some stadials was reminiscent of the Last Glacial Maximum. This study builds upon previous records in showing that millennial-scale shifts were an inherent feature of Northern Hemisphere glacial climates since 735 ka, and they remained remarkably constant in the details of their amplitude, cyclicity, and temperature variability.

Assessing the intra-species genetic variability in the clonal pathogen Campylobacter fetus: CRISPRs are highly polymorphic DNA markers.

PubMed

Calleros, Lucía; Betancor, Laura; Iraola, Gregorio; Méndez, Alejandra; Morsella, Claudia; Paolicchi, Fernando; Silveyra, Silvia; Velilla, Alejandra; Pérez, Ruben

2017-01-01

Campylobacter fetus is a Gram-negative, microaerophilic bacterium that infects animals and humans. The subspecies Campylobacter fetus subsp. fetus (Cff) affects a broad range of vertebrate hosts and induces abortion in cows and sheep. Campylobacter fetus subsp. venerealis (Cfv) is restricted to cattle and causes the endemic disease bovine genital campylobacteriosis, which triggers reproductive problems and is responsible for major economic losses. Campylobacter fetus subsp. testudinum (Cft) has been isolated mostly from apparently healthy reptiles belonging to different species but also from ill snakes and humans. Genotypic differentiation of Cff and Cfv is difficult, and epidemiological information is scarce because there are few methods to study the genetic diversity of the strains. We analyze the efficacy of MLST, ribosomal sequences (23S gene and internal spacer region), and CRISPRs to assess the genetic variability of C. fetus in bovine and human isolates. Sequences retrieved from complete genomes were included in the analysis for comparative purposes. MLST and ribosomal sequences had scarce or null variability, while the CRISPR-cas system structure and the sequence of CRISPR1 locus showed remarkable diversity. None of the sequences here analyzed provided evidence of a genetic differentiation of Cff and Cfv in bovine isolates. Comparison of bovine and human isolates with Cft strains showed a striking divergence. Inter-host differences raise the possibility of determining the original host of human infections using CRISPR sequences. CRISPRs are the most variable sequences analyzed in C. fetus so far, and constitute excellent representatives of a dynamic fraction of the genome. CRISPR typing is a promising tool to characterize isolates and to track the source and transmission route of C. fetus infections. Copyright © 2016 Elsevier B.V. All rights reserved.

Influence of continuous haemofiltration-related hypothermia on haemodynamic variables and gas exchange in septic patients.

PubMed

Matamis, D; Tsagourias, M; Koletsos, K; Riggos, D; Mavromatidis, K; Sombolos, K; Bursztein, S

1994-07-01

To investigate the influence of continuous haemofiltration (CHF) on haemodynamics, gas exchange and core temperature in critically ill septic patients with acute renal failure. In 20 patients (17 male, 3 female) ultrafiltration rate, core temperature, gas exchange and haemodynamic variables were measured at regular intervals during the first 48 h of haemofiltration. Baseline data were compared to those obtained 30 min after initiating CHF and also to those during hypothermia (if observed). Haemodynamic variables remained remarkably constant throughout the study period. In patients with a relatively low ultrafiltration rate (855 +/- 278 ml/h) temperature did not change, while in patients with a high ultrafiltration rate (1468 +/- 293 ml/h) core temperature significantly decreased from 37.6 +/- 0.9 degrees C to 34.8 +/- 0.8 degrees C (p < 0.001). There was a statistically significant correlation between temperature decrease and ultrafiltration rate (r = -0.68, Y = 1.8-0.003 X, p < 0.01). Hypothermic patients also showed a mean decrease in VO2 from 141 +/- 22 ml/min/m2 to 112 +/- 22 ml/min/m2 (p < 0.01) with a concomitant increase in PaO2 from 103 +/- 37 mmHg to 140 +/- 42 mmHg (p < 0.001) and in PvO2 from 35 +/- 4 mmHg to 41 +/- 5 mmHg (p < 0.001). 1) Continuous haemofiltration does not cause significant alternations in haemodynamic variables. 2) Hypothermia frequently occurs in patients undergoing continuous haemofiltration with high ultrafiltration rates. These hypothermic patients show a reduction in VO2 leading to an increase in PvO2 and PaO2. This mild hypothermia in these circumstances has no evident deleterious effects.

Detailed Analysis of the Microbial Population in Malaysian Spontaneous Cocoa Pulp Fermentations Reveals a Core and Variable Microbiota

PubMed Central

Mathawan, Melissa; Wittocx, Pieter-Jan; Saels, Veerle; Struyf, Nore; Bernaert, Herwig; Vrancken, Gino; Verstrepen, Kevin J.

2013-01-01

The fermentation of cocoa pulp is one of the few remaining large-scale spontaneous microbial processes in today's food industry. The microbiota involved in cocoa pulp fermentations is complex and variable, which leads to inconsistent production efficiency and cocoa quality. Despite intensive research in the field, a detailed and comprehensive analysis of the microbiota is still lacking, especially for the expanding Asian production region. Here, we report a large-scale, comprehensive analysis of four spontaneous Malaysian cocoa pulp fermentations across two time points in the harvest season and two fermentation methods. Our results show that the cocoa microbiota consists of a “core” and a “variable” part. The bacterial populations show a remarkable consistency, with only two dominant species, Lactobacillus fermentum and Acetobacter pasteurianus. The fungal diversity is much larger, with four dominant species occurring in all fermentations (“core” yeasts), and a large number of yeasts that only occur in lower numbers and specific fermentations (“variable” yeasts). Despite this diversity, a clear pattern emerges, with early dominance of apiculate yeasts and late dominance of Saccharomyces cerevisiae. Our results provide new insights into the microbial diversity in Malaysian cocoa pulp fermentations and pave the way for the selection of starter cultures to increase efficiency and consistency. PMID:24358116

Seasonal and Interannual Variability of the Brazil - Malvinas Front: an Altimetry Perspective

NASA Astrophysics Data System (ADS)

Saraceno, M.; Valla, D.; Pelegrí, J. L.; Piola, A. R.

2016-02-01

The Brazil and Malvinas Confluence in the Southwestern Atlantic is one of the most energetic regions of the world ocean. Using recent measurements of sub-surface velocity currents, collected along 2348 nautical miles with a vessel mounted acoustic Doppler profiler onboard R/V BIO Hespérides, we validate geostrophic velocities derived from gridded fields of sea surface height (SSH). A remarkable correspondence between in-situ surface hydrographic data collected from the vessel and satellite sea surface temperature (SST), color and altimetry data allows selecting a specific SSH contour to track the position of the Brazil-Malvinas front. We then use 22 years of SSH data distributed by AVISO to show that the Brazil-Malvinas front shows a NS orientation in winter and a NE-SW orientation in summer, in good agreement with results based on the analysis of SST gradients. Furthermore, a clear southward migration of the front during the 22 year period is observed. The migration is associated with the southward shift of the South Atlantic high-pressure system that is in turn related to large climate changes in the southern portion of the South American continent. The seasonal variability in the orientation of the front is related to the Brazil and Malvinas encountering currents.

Numerical Modeling of River Fluxes Under Changing Environmental Conditions (Invited)

NASA Astrophysics Data System (ADS)

Simpson, G.

2013-12-01

High frequency climate cycles have a major impact on landscapes, but it remains uncertain if alluvial rivers can transfer the resulting sediment pulses downstream to sedimentary basins. Stratigraphic records located near the mouth of rivers exhibit cyclicity consistent with orbital forcing. However, in some cases, the sediment supply from rivers appears to have remained remarkably constant despite changes in climate, which has been interpreted to indicate that rivers dampen rapid variability. Here, we employ a physically-based numerical model to resolve this outstanding problem. Our simulations show that rivers forced with water flux cycles exhibit highly pulsed sediment outflux records, even when the period of forcing is several orders of magnitude shorter than river response times. This non-linear amplified system response characterised by positive feedback is related to the strong negative correlation between water flux and the equilibrium slope of a river. We also show that the apparent stability of sediment fluxes based on time-averaged data is an artifact of integrating highly episodic records over multiple cycles rather than a signature of diffusive floodplain processes. We conclude that marine sedimentary basins may record sediment-flux cycles resulting from discharge (and ultimately climate) variability, whereas they may be relatively insensitive to pure sediment-flux perturbations (such as for example those induced by tectonics).

X-ray signatures: New time scales and spectral features

NASA Technical Reports Server (NTRS)

Boldt, E. A.

1977-01-01

The millisecond bursts from Cyg X-1 are investigated and the overall chaotic variability for the bulk of the Cyg X-1 emission is compared to that of Sco X-1, showing that the essential character is remarkably similar (i.e. shot noise) although the fundamental time scales involved differ widely, from a fraction of a second (for Cyg X-1) to a fraction of a day (for Sco X-1). Recent OSO-8 observations of spectra features attributable to iron are reviewed. In particular, line emission is discussed within the context of a model for thermal radiation by a hot evolved gas in systems as different as supernova remnants and clusters of galaxies. Newly observed spectral structure in the emission from the X-ray pulsar Her X-1 is reported.

Equilibrium concentration profiles and sedimentation kinetics of colloidal gels under gravitational stress

NASA Astrophysics Data System (ADS)

Buzzaccaro, S.; Secchi, E.; Brambilla, G.; Piazza, R.; Cipelletti, L.

2012-07-01

We study the sedimentation of colloidal gels by using a combination of light scattering, polarimetry and video imaging. The asymptotic concentration profiles φ(z,t → ∞) exhibit remarkable scaling properties: profiles for gels prepared at different initial volume fractions and particle interactions can be superimposed onto a single master curve by using suitable reduced variables. We show theoretically that this behavior stems from a power law dependence of the compressive elastic modulus versus φ, which we directly test experimentally. The sedimentation kinetics comprises an initial latency stage, followed by a rapid collapse where the gel height h decreases at constant velocity and a final compaction stage characterized by a stretched exponential relaxation of h toward a plateau. Analogies and differences with previous works are briefly discussed.

Biophysical Aspects of Spindle Evolution

NASA Astrophysics Data System (ADS)

Farhadifar, Reza; Baer, Charlie; Needleman, Daniel

2011-03-01

The continual propagation of genetic material from one generation to the next is one of the most basic characteristics of all organisms. In eukaryotes, DNA is segregated into the two daughter cells by a highly dynamic, self-organizing structure called the mitotic spindle. Mitotic spindles can show remarkable variability between tissues and organisms, but there is currently little understanding of the biophysical and evolutionary basis of this diversity. We are studying how spontaneous mutations modify cell division during nematode development. By comparing the mutational variation - the raw material of evolution - with the variation present in nature, we are investigating how the mitotic spindle is shaped over the course of evolution. This combination of quantitative genetics and cellular biophysics gives insight into how the structure and dynamics of the spindle is formed through selection, drift, and biophysical constraints.

Determination of Domoic Acid in Plankton Net Samples from Golden Horn Estuary, Turkey, Using HPLC with Fluorescence Detection.

PubMed

Dursun, Fuat; Ünlü, Selma; Yurdun, Türkan

2018-03-01

This study focused on the fluctuations of domoic acid (DA) levels in plankton net samples collected from the Golden Horn Estuary (GHE), Turkey, between August 2011 and July 2012. DA concentrations were determined by high-performance liquid chromatography (HPLC), using a fluorenylmethoxycarbonyl (FMOC) derivatization technique. Monthly and biweekly data were evaluated with environmental variables, and their influence on DA production is discussed. DA levels in plankton net samples varied between 0.36 and 94.34 µg L - 1 . DA levels showed remarkable seasonal variation and they were generally higher in May, 2012, but no DA was detected between February and April, 2012. DA production was mostly controlled by temperature, with nitrate and silicate limitations being secondary factors that influenced DA concentrations.

Expression, production, and renaturation of a functional single-chain variable antibody fragment (scFv) against human ICAM-1

PubMed Central

Sun, H.; Wu, G.M.; Chen, Y.Y.; Tian, Y.; Yue, Y.H.; Zhang, G.L.

2014-01-01

Intercellular adhesion molecule-1 (ICAM-1) is an important factor in the progression of inflammatory responses in vivo. To develop a new anti-inflammatory drug to block the biological activity of ICAM-1, we produced a monoclonal antibody (Ka=4.19×10−8 M) against human ICAM-1. The anti-ICAM-1 single-chain variable antibody fragment (scFv) was expressed at a high level as inclusion bodies in Escherichia coli. We refolded the scFv (Ka=2.35×10−7 M) by ion-exchange chromatography, dialysis, and dilution. The results showed that column chromatography refolding by high-performance Q Sepharose had remarkable advantages over conventional dilution and dialysis methods. Furthermore, the anti-ICAM-1 scFv yield of about 60 mg/L was higher with this method. The purity of the final product was greater than 90%, as shown by denaturing gel electrophoresis. Enzyme-linked immunosorbent assay, cell culture, and animal experiments were used to assess the immunological properties and biological activities of the renatured scFv. PMID:24919171

Taking Poseidon's Measure from Space: Advances in our Understanding of the Ocean

NASA Astrophysics Data System (ADS)

Avery, S. K.

2017-12-01

In many ways the ocean defines our planet and makes it livable. It provides marine resources and ecosystem services that are critical to a sustainable society. Today we understand that there is a growing need to predict, manage, and adapt to changes on our planet - changes that occur not only in the atmosphere but also in the ocean. Over the last 40 years remarkable advances in measuring key ocean quantities have been made - through the development of new satellite technologies and successful missions as well as through in-situ observing systems enabled by advances in robotics, communications, navigation, and sensors. Ocean science (and atmospheric science) is a science of numbers, imaging, and numerical models. Predictability of the ocean is tied to the scale of variability in space and time. Satellite observations have spectacularly showed us the incredible structure and variability of the ocean. It has been the combination of satellites and in-situ sensors that have allowed us to advance understanding and prediction. This presentation will highlight some of the key scientific advances that have been enabled by satellites.

A global multiproxy database for temperature reconstructions of the Common Era.

PubMed

2017-07-11

Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records are from trees, ice, sediment, corals, speleothems, documentary evidence, and other archives. They range in length from 50 to 2000 years, with a median of 547 years, while temporal resolution ranges from biweekly to centennial. Nearly half of the proxy time series are significantly correlated with HadCRUT4.2 surface temperature over the period 1850-2014. Global temperature composites show a remarkable degree of coherence between high- and low-resolution archives, with broadly similar patterns across archive types, terrestrial versus marine locations, and screening criteria. The database is suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python.

[The framing effect: medical implications].

PubMed

Mazzocco, Ketti; Cherubini, Paolo; Rumiati, Rino

2005-01-01

Over the last 20 years, many studies explored how the way information is presented modifies choices. This sort of effect, referred to as "framing effects", typically consists of the inversion of choices when presenting structurally identical decision problems in different ways. It is a common assumption that physicians are unaffected (or less affected) by the surface description of a decision problem, because they are formally trained in medical decision making. However, several studies showed that framing effects occur even in the medical field. The complexity and variability of these effects are remarkable, making it necessary to distinguish among different framing effects, depending on whether the effect is obtained by modifying adjectives (attribute framing), goals of a behavior (goal framing), or the probability of an outcome (risky choice framing). A further reason for the high variability of the framing effects seems to be the domain of the decision problem, with different effects occurring in prevention decisions, disease-detection decisions, and treatment decisions. The present work reviews the studies on framing effects, in order to summarize them and clarify their possible role in medical decision making.

Determinants of the cost of capital for privately financed hospital projects in the UK.

PubMed

Colla, Paolo; Hellowell, Mark; Vecchi, Veronica; Gatti, Stefano

2015-11-01

Many governments make use of private finance contracts to deliver healthcare infrastructure. Previous work has shown that the rate of return to investors in these markets often exceeds the efficient level. Our focus is on the factors that influence that return. We examine the effect of macroeconomic, project- and firm-level variables using a detailed sample of 84 UK private finance initiative (PFI) contracts signed between 1997 and 2010. Of the above variables, macroeconomic conditions and lead sponsor size are related to the investor return. However, our results show a remarkable degree of stability in the return to investors over the 14-year period. We find evidence of a 'prevailing norm' that is robust to project- and firm-level variation. The sustainability of excess returns over a long period is indicative of a concentrated market structure. We argue that policymakers should consider new mechanisms for increasing competition in the equity market, while ensuring that authorities have the specialist resources required to negotiate efficient contract prices. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

A phylogenetic study of Boletus section Boletus in Europe.

PubMed

Beugelsdijk, D C M; van der Linde, S; Zuccarello, G C; den Bakker, H C; Draisma, S G A; Noordeloos, M E

2008-06-01

A phylogenetic study of the species in Boletus sect. Boletus was undertaken using the molecular markers ITS1-5.8S-ITS2 and GAPDH. Four well-supported lineages, one comprising Boletus edulis s.l., the others referring to B. aereus, B. reticulatus and B. pinophilus have been distinguished. The ML and MP trees of ITS showed remarkably low resolution within the B. edulis clade, and confirmed earlier published results, despite the use of samples from a wider geographical area and different hosts. The results of GAPDH demonstrate clearly that this low resolution must be ascribed to a low genetic variability with the B. edulis clade, and make clear that morphological and ecological characters have been overestimated within this species complex. Boletus edulis is therefore defined as a variable species with a wide morphological, ecological and geographic range, and includes several specific and subspecific taxa described in the literature (e.g. B. betulicola, B. persoonii, B. quercicola and B. venturii). Three other European species (B. aereus, B. pinophilus and B. reticulatus) are well delimited species based on morphology and our genetic data.

A global multiproxy database for temperature reconstructions of the Common Era

USGS Publications Warehouse

Emile-Geay, Julian; McKay, Nicholas P.; Kaufman, Darrell S.; von Gunten, Lucien; Wang, Jianghao; Anchukaitis, Kevin J.; Abram, Nerilie J.; Addison, Jason A.; Curran, Mark A.J.; Evans, Michael N.; Henley, Benjamin J.; Hao, Zhixin; Martrat, Belen; McGregor, Helen V.; Neukom, Raphael; Pederson, Gregory T.; Stenni, Barbara; Thirumalai, Kaustubh; Werner, Johannes P.; Xu, Chenxi; Divine, Dmitry V.; Dixon, Bronwyn C.; Gergis, Joelle; Mundo, Ignacio A.; Nakatsuka, T.; Phipps, Steven J.; Routson, Cody C.; Steig, Eric J.; Tierney, Jessica E.; Tyler, Jonathan J.; Allen, Kathryn J.; Bertler, Nancy A. N.; Bjorklund, Jesper; Chase, Brian M.; Chen, Min-Te; Cook, Ed; de Jong, Rixt; DeLong, Kristine L.; Dixon, Daniel A.; Ekaykin, Alexey A.; Ersek, Vasile; Filipsson, Helena L.; Francus, Pierre; Freund, Mandy B.; Frezzotti, M.; Gaire, Narayan P.; Gajewski, Konrad; Ge, Quansheng; Goosse, Hugues; Gornostaeva, Anastasia; Grosjean, Martin; Horiuchi, Kazuho; Hormes, Anne; Husum, Katrine; Isaksson, Elisabeth; Kandasamy, Selvaraj; Kawamura, Kenji; Koc, Nalan; Leduc, Guillaume; Linderholm, Hans W.; Lorrey, Andrew M.; Mikhalenko, Vladimir; Mortyn, P. Graham; Motoyama, Hideaki; Moy, Andrew D.; Mulvaney, Robert; Munz, Philipp M.; Nash, David J.; Oerter, Hans; Opel, Thomas; Orsi, Anais J.; Ovchinnikov, Dmitriy V.; Porter, Trevor J.; Roop, Heidi; Saenger, Casey; Sano, Masaki; Sauchyn, David; Saunders, K.M.; Seidenkrantz, Marit-Solveig; Severi, Mirko; Shao, X.; Sicre, Marie-Alexandrine; Sigl, Michael; Sinclair, Kate; St. George, Scott; St. Jacques, Jeannine-Marie; Thamban, Meloth; Thapa, Udya Kuwar; Thomas, E.; Turney, Chris; Uemura, Ryu; Viau, A.E.; Vladimirova, Diana O.; Wahl, Eugene; White, James W. C.; Yu, Z.; Zinke, Jens

2017-01-01

Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records are from trees, ice, sediment, corals, speleothems, documentary evidence, and other archives. They range in length from 50 to 2000 years, with a median of 547 years, while temporal resolution ranges from biweekly to centennial. Nearly half of the proxy time series are significantly correlated with HadCRUT4.2 surface temperature over the period 1850–2014. Global temperature composites show a remarkable degree of coherence between high- and low-resolution archives, with broadly similar patterns across archive types, terrestrial versus marine locations, and screening criteria. The database is suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python.

SOAP. A tool for the fast computation of photometry and radial velocity induced by stellar spots

NASA Astrophysics Data System (ADS)

Boisse, I.; Bonfils, X.; Santos, N. C.

2012-09-01

We define and put at the disposal of the community SOAP, Spot Oscillation And Planet, a software tool that simulates the effect of stellar spots and plages on radial velocimetry and photometry. This paper describes the tool release and provides instructions for its use. We present detailed tests with previous computations and real data to assess the code's performance and to validate its suitability. We characterize the variations of the radial velocity, line bisector, and photometric amplitude as a function of the main variables: projected stellar rotational velocity, filling factor of the spot, resolution of the spectrograph, linear limb-darkening coefficient, latitude of the spot, and inclination of the star. Finally, we model the spot distributions on the active stars HD 166435, TW Hya and HD 189733, which reproduce the observations. We show that the software is remarkably fast, allowing several evolutions in its capabilities that could be performed to study the next challenges in the exoplanetary field connected with the stellar variability. The tool is available at http://www.astro.up.pt/soap

A global multiproxy database for temperature reconstructions of the Common Era

PubMed Central

Emile-Geay, Julien; McKay, Nicholas P.; Kaufman, Darrell S.; von Gunten, Lucien; Wang, Jianghao; Anchukaitis, Kevin J.; Abram, Nerilie J.; Addison, Jason A.; Curran, Mark A.J.; Evans, Michael N.; Henley, Benjamin J.; Hao, Zhixin; Martrat, Belen; McGregor, Helen V.; Neukom, Raphael; Pederson, Gregory T.; Stenni, Barbara; Thirumalai, Kaustubh; Werner, Johannes P.; Xu, Chenxi; Divine, Dmitry V.; Dixon, Bronwyn C.; Gergis, Joelle; Mundo, Ignacio A.; Nakatsuka, Takeshi; Phipps, Steven J.; Routson, Cody C.; Steig, Eric J.; Tierney, Jessica E.; Tyler, Jonathan J.; Allen, Kathryn J.; Bertler, Nancy A.N.; Björklund, Jesper; Chase, Brian M.; Chen, Min-Te; Cook, Ed; de Jong, Rixt; DeLong, Kristine L.; Dixon, Daniel A.; Ekaykin, Alexey A.; Ersek, Vasile; Filipsson, Helena L.; Francus, Pierre; Freund, Mandy B.; Frezzotti, Massimo; Gaire, Narayan P.; Gajewski, Konrad; Ge, Quansheng; Goosse, Hugues; Gornostaeva, Anastasia; Grosjean, Martin; Horiuchi, Kazuho; Hormes, Anne; Husum, Katrine; Isaksson, Elisabeth; Kandasamy, Selvaraj; Kawamura, Kenji; Kilbourne, K. Halimeda; Koç, Nalan; Leduc, Guillaume; Linderholm, Hans W.; Lorrey, Andrew M.; Mikhalenko, Vladimir; Mortyn, P. Graham; Motoyama, Hideaki; Moy, Andrew D.; Mulvaney, Robert; Munz, Philipp M.; Nash, David J.; Oerter, Hans; Opel, Thomas; Orsi, Anais J.; Ovchinnikov, Dmitriy V.; Porter, Trevor J.; Roop, Heidi A.; Saenger, Casey; Sano, Masaki; Sauchyn, David; Saunders, Krystyna M.; Seidenkrantz, Marit-Solveig; Severi, Mirko; Shao, Xuemei; Sicre, Marie-Alexandrine; Sigl, Michael; Sinclair, Kate; St. George, Scott; St. Jacques, Jeannine-Marie; Thamban, Meloth; Kuwar Thapa, Udya; Thomas, Elizabeth R.; Turney, Chris; Uemura, Ryu; Viau, Andre E.; Vladimirova, Diana O.; Wahl, Eugene R.; White, James W.C.; Yu, Zicheng; Zinke, Jens

2017-01-01

Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records are from trees, ice, sediment, corals, speleothems, documentary evidence, and other archives. They range in length from 50 to 2000 years, with a median of 547 years, while temporal resolution ranges from biweekly to centennial. Nearly half of the proxy time series are significantly correlated with HadCRUT4.2 surface temperature over the period 1850–2014. Global temperature composites show a remarkable degree of coherence between high- and low-resolution archives, with broadly similar patterns across archive types, terrestrial versus marine locations, and screening criteria. The database is suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python. PMID:28696409

Intrafamilial variability of the ocular phenotype in a Polish family with a missense mutation (A63D) in the Norrie disease gene.

PubMed

Zaremba, J; Feil, S; Juszko, J; Myga, W; van Duijnhoven, G; Berger, W

1998-09-01

To describe the phenotypic variability in a Polish Norrie disease (ND) family associated with the missense mutation A63D. A patient with spared vision from a Polish ND family underwent detailed ophthalmological examinations including slit-lamp biomicroscopy, ultrasound (USG), angiography, Goldmann kinetic visual field, and electroretinography (ERG). Mutation screening was carried out using the single-strand conformation polymorphism (SSCP) technique and subsequent DNA sequencing of the coding part of the ND gene. A mutation was detected (exon 3, A63D) in a large Polish family with 12 affected males, all but one presenting with classical ND symptoms. In one male, partially preserved vision was observed up to 40 years of age (distance acuity of the right eye 1/50 and left eye 2/50). Slit-lamp examination revealed remnants of a persistent primary vitreous and hyaloid artery. Upon angiography, the retina was vascularized within the posterior pole but not in the periphery. The ERG revealed pathological changes characteristic for chorioretinal degenerations. Within one family, individuals with identical sequence alterations in the ND gene can show remarkable phenotypic variability of the ocular symptoms. These findings indicate the involvement of additional factors (epigenetic or genetic) in ocular pathogenesis of ND.

On the nature of the high-energy rollover in 1H 0419-577

NASA Astrophysics Data System (ADS)

Turner, T. J.; Reeves, J. N.; Braito, V.; Costa, M.

2018-05-01

A NuSTAR/Swift observation of the luminous Seyfert 1 galaxy 1H 0419-577 taken during 2015 reveals one of the most extreme high-energy cut-offs observed to date from an AGN - an origin due to thermal Comptonization would imply a remarkably low coronal temperature kT ˜ 15 keV. The low-energy peak of the spectrum in the hard X-ray NuSTAR band, which peaks before the expected onset of a Compton hump, rules out strong reflection as the origin of the hard excess in this AGN. We show the origin of the high-energy rollover is likely due to a combination of both thermal Comptonization and an intrinsically steeper continuum, which is modified by absorption at lower energies. Furthermore, modelling the broad-band XUV continuum shape as a colour-corrected accretion disc, requires the presence of a variable warm absorber to explain all flux and spectral states of the source, consistent with the previous work on this AGN. While absorber variations produce marked spectral variability in this AGN, consideration of all flux states allows us to isolate a colourless component of variability that may arise from changes in the inner accretion flow, typically at around 10 rg.

What do foraging wasps optimize in a variable environment, energy investment or body temperature?

PubMed

Kovac, Helmut; Stabentheiner, Anton; Brodschneider, Robert

2015-11-01

Vespine wasps (Vespula sp.) are endowed with a pronounced ability of endothermic heat production. To show how they balance energetics and thermoregulation under variable environmental conditions, we measured the body temperature and respiration of sucrose foragers (1.5 M, unlimited flow) under variable ambient temperature (T a = 20-35 °C) and solar radiation (20-570 W m(-2)). Results revealed a graduated balancing of metabolic efforts with thermoregulatory needs. The thoracic temperature in the shade depended on ambient temperature, increasing from ~37 to 39 °C. However, wasps used solar heat gain to regulate their thorax temperature at a rather high level at low T a (mean T thorax ~ 39 °C). Only at high T a they used solar heat to reduce their metabolic rate remarkably. A high body temperature accelerated the suction speed and shortened foraging time. As the costs of foraging strongly depended on duration, the efficiency could be significantly increased with a high body temperature. Heat gain from solar radiation enabled the wasps to enhance foraging efficiency at high ambient temperature (T a = 30 °C) by up to 63 %. The well-balanced change of economic strategies in response to environmental conditions minimized costs of foraging and optimized energetic efficiency.

Abuse and neglect of the frail elderly at home: an exploration of theoretical relationships.

PubMed

Phillips, L R

1983-09-01

Using an ex post facto, correlational descriptive design, a purposive sample of 74 elderly individuals who were identified as either having a 'good relationship' or an 'abusive/neglectful relationship' with their related caregivers were interviewed in their own homes. The purpose of the study was to test two hypotheses which predicted the nature of differences between the two groups and four which predicted the magnitude and direction of theoretically deduced causal relationships. The data showed that demographic characteristics and certain theoretical variable such as anger, hostility and stress were remarkably similar between groups. The significant differences (P less than 0.05) between the two groups included lower expectations among the abused subjects for their caregivers, lower perceptions among the abused subjects of their caregiver's actual behaviour, differences between the social networks of the two groups and more depression in the 'abuse' group. Using multiple regression analysis, a total of four causal models' were tested using anger, depression, anxiety, and abuse as terminal dependent variables. The amount of explained variance ranged from 22% for anxiety to 58% for abuse. An empirical model was generated from data available in which 2 variables, perceptions of the caregiver and family members in the house available to help, explained 54% of the variance in abuse.

Dynamic Alignment Models for Neural Coding

PubMed Central

Kollmorgen, Sepp; Hahnloser, Richard H. R.

2014-01-01

Recently, there have been remarkable advances in modeling the relationships between the sensory environment, neuronal responses, and behavior. However, most models cannot encompass variable stimulus-response relationships such as varying response latencies and state or context dependence of the neural code. Here, we consider response modeling as a dynamic alignment problem and model stimulus and response jointly by a mixed pair hidden Markov model (MPH). In MPHs, multiple stimulus-response relationships (e.g., receptive fields) are represented by different states or groups of states in a Markov chain. Each stimulus-response relationship features temporal flexibility, allowing modeling of variable response latencies, including noisy ones. We derive algorithms for learning of MPH parameters and for inference of spike response probabilities. We show that some linear-nonlinear Poisson cascade (LNP) models are a special case of MPHs. We demonstrate the efficiency and usefulness of MPHs in simulations of both jittered and switching spike responses to white noise and natural stimuli. Furthermore, we apply MPHs to extracellular single and multi-unit data recorded in cortical brain areas of singing birds to showcase a novel method for estimating response lag distributions. MPHs allow simultaneous estimation of receptive fields, latency statistics, and hidden state dynamics and so can help to uncover complex stimulus response relationships that are subject to variable timing and involve diverse neural codes. PMID:24625448

On the comparisons of tropical relative humidity in the lower and middle troposphere among COSMIC radio occultations, MERRA and ECMWF data sets

NASA Astrophysics Data System (ADS)

Vergados, P.; Mannucci, A. J.; Ao, C. O.; Jiang, J. H.; Su, H.

2015-01-01

The spatial variability of the tropical tropospheric relative humidity (RH) throughout the vertical extent of the troposphere is examined using Global Positioning System Radio Occultation (GPSRO) observations from the Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) mission. These high vertical resolution observations capture the detailed structure and moisture budget of the Hadley Cell circulation. We compare the COSMIC observations with the European Center for Medium-range Weather Forecast (ECMWF) Re-Analysis Interim (ERA-Interim) and the Modern-Era Retrospective analysis for Research and Applications (MERRA) climatologies. Qualitatively, the spatial pattern of RH in all data sets matches up remarkably well, capturing distinct features of the general circulation. However, RH discrepancies exist between ERA-Interim and COSMIC data sets, which are noticeable across the tropical boundary layer. Specifically, ERA-Interim shows a drier Inter Tropical Convergence Zone (ITCZ) by 15-20% compared both to COSMIC and MERRA data sets, but this difference decreases with altitude. Unlike ECMWF, MERRA shows an excellent agreement with the COSMIC observations except above 400 hPa, where GPSRO observations capture drier air by 5-10%. RH climatologies were also used to evaluate intraseasonal variability. The results indicate that the tropical middle troposphere at ±5-25° is most sensitive to seasonal variations. COSMIC and MERRA data sets capture the same magnitude of the seasonal variability, but ERA-Interim shows a weaker seasonal fluctuation up to 10% in the middle troposphere inside the dry air subsidence regions of the Hadley Cell. Over the ITCZ, RH varies by maximum 9% between winter and summer.

On the comparisons of tropical relative humidity in the lower and middle troposphere among COSMIC radio occultations and MERRA and ECMWF data sets

NASA Astrophysics Data System (ADS)

Vergados, P.; Mannucci, A. J.; Ao, C. O.; Jiang, J. H.; Su, H.

2015-04-01

The spatial variability of the tropical tropospheric relative humidity (RH) throughout the vertical extent of the troposphere is examined using Global Positioning System Radio Occultation (GPSRO) observations from the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) mission. These high vertical resolution observations capture the detailed structure and moisture budget of the Hadley Cell circulation. We compare the COSMIC observations with the European Center for Medium-range Weather Forecast (ECMWF) Reanalysis Interim (ERA-Interim) and the Modern-Era Retrospective analysis for Research and Applications (MERRA) climatologies. Qualitatively, the spatial pattern of RH in all data sets matches up remarkably well, capturing distinct features of the general circulation. However, RH discrepancies exist between ERA-Interim and COSMIC data sets that are noticeable across the tropical boundary layer. Specifically, ERA-Interim shows a drier Intertropical Convergence Zone (ITCZ) by 15-20% compared to both COSMIC and MERRA data sets, but this difference decreases with altitude. Unlike ECMWF, MERRA shows an excellent agreement with the COSMIC observations except above 400 hPa, where GPSRO observations capture drier air by 5-10%. RH climatologies were also used to evaluate intraseasonal variability. The results indicate that the tropical middle troposphere at ±5-25° is most sensitive to seasonal variations. COSMIC and MERRA data sets capture the same magnitude of the seasonal variability, but ERA-Interim shows a weaker seasonal fluctuation up to 10% in the middle troposphere inside the dry air subsidence regions of the Hadley Cell. Over the ITCZ, RH varies by maximum 9% between winter and summer.

Some remarks on the current status of the control theory of single space dimension hyperbolic systems

NASA Technical Reports Server (NTRS)

Russell, D. L.

1983-01-01

Various aspects of the control theory of hyperbolic systems, including controllability, stabilization, control canonical form theory, etc., are reviewed. To allow a unified and not excessively technical treatment, attention is restricted to the case of a single space variable. A newly developed procedure of canonical augmentation is discussed.

Exploring the Links in Monthly to Decadal Variability of the Atmospheric Water Balance Over the Wettest Regions in ERA-20C

NASA Astrophysics Data System (ADS)

Nogueira, M.

2017-10-01

Monthly-to-decadal variability of the regional precipitation over Intertropical Convergence Zone and north-Atlantic and north-Pacific storm tracks was investigated using ERA-20C reanalysis. Satellite-based precipitation (P) and evaporation (E) climatological patterns were well reproduced by ERA-20C. Regional P and E monthly time series displayed 20% differences, but these decreased rapidly with time scale ( 10% at yearly time scales). Spectral analysis showed good scale-by-scale statistical agreement between ERA-20C and observations. Using ERA-Interim showed no improvement despite the much wider range of information assimilated (including satellites). Remarkably high Detrended Cross-Correlation Analysis coefficients (ρDCCA > 0.7 and often ρDCCA > 0.9) revealed tight links between the nonperiodic variability of P, moisture divergence (DIV), and pressure velocity (ω) at monthly-to-decadal time scales over all the wet regions. In contrast, ρDCCA was essentially nonsignificant between nonperiodic P and E or sea surface temperature (SST). Thus, the nonperiodic monthly-to-decadal variability of precipitation in these regions is almost fully controlled by dynamics and not by local E or SST (suggested by Clausius-Clapeyron relation). Analysis of regional nonperiodic standard deviations and power spectra (and respective spectral exponents, β) provided further robustness to this conclusion. Finally, clear transitions in β for P, DIV, and ω between tropical and storm track regions were found. The latter is dominated by transient storms, with energy accumulation at synoptic scales and β < 0.1 at monthly-to-decadal time scales, implying that variability and information creation decrease rapidly with time scale. Larger β values (0.2 to 0.4) were found in the tropics, implying longer-range autocorrelations and slower decreasing variability and information creation with time scale, consistent with the important forcing from internal modes of variability (e.g., El Niño-Southern Oscillation).

Lateral variations in lithospheric and landscape evolution at both ends of the Himalaya-Tibet orogen

NASA Astrophysics Data System (ADS)

Zeitler, P. K.; Schmidt, J. L.; Meltzer, A.

2015-12-01

At the broadest scale, like many orogens the Himalaya encompass a range of orogenic features that are remarkably similar along much of the length of the mountain belt and its neighboring terranes. At one scale of consideration, these similarities appear to be a signal that fundamental processes associated with lithospheric collision have been active. However, the vast size of the Himalaya and Tibet, the different climate regimes experienced by the orogen across time and space, and the along-strike variations in the continental and arc margins that faced one another before collision, make it at once remarkable that any similarities exist, and important to more critically evaluate their nature. The eastern and western Himalayan syntaxes confound any attempt to generalize too much about the Himalaya-Tibet orogen. By area these features occupy at least 25% of the orogenic belt, and compared to the "main" portions of the arc they show clear differences in their lithospheric structures, landscapes, and evolution. The boundary and initial conditions that shaped the eastern and western indentor corners were and are different, as is the nature and timing of erosional exhumation. Some of the most active geologic processes on Earth have recently been in play within the syntaxes, and the evolution of landscapes and fluvial systems, important in developing the sedimentary record of the Himalaya-Tibet system, has been complex and variable in space and time. Southeasternmost Tibet and the Lhasa Block in particular exemplify this complexity both in its complex topographic evolution linked to surface processes and climate, and in lateral variability in lithospheric structure. Taking a system viewpoint, an important question to debate is the degree to which there are features in the Himalaya-Tibet system that are robustly emergent, given the broad boundary conditions of the continental collision plus the suite of local and regional geodynamical processes that have operated during orogenesis. A related question is the degree to which the variability seen within the orogen represents important information about process that is exportable to other orogens, or is in effect tectonic noise contingent on local geologic details and secular changes.

Coupled-oscillator theory of dispersion and Casimir-Polder interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berman, P. R.; Ford, G. W.; Milonni, P. W.

2014-10-28

We address the question of the applicability of the argument theorem (of complex variable theory) to the calculation of two distinct energies: (i) the first-order dispersion interaction energy of two separated oscillators, when one of the oscillators is excited initially and (ii) the Casimir-Polder interaction of a ground-state quantum oscillator near a perfectly conducting plane. We show that the argument theorem can be used to obtain the generally accepted equation for the first-order dispersion interaction energy, which is oscillatory and varies as the inverse power of the separation r of the oscillators for separations much greater than an optical wavelength.more » However, for such separations, the interaction energy cannot be transformed into an integral over the positive imaginary axis. If the argument theorem is used incorrectly to relate the interaction energy to an integral over the positive imaginary axis, the interaction energy is non-oscillatory and varies as r{sup −4}, a result found by several authors. Rather remarkably, this incorrect expression for the dispersion energy actually corresponds to the nonperturbative Casimir-Polder energy for a ground-state quantum oscillator near a perfectly conducting wall, as we show using the so-called “remarkable formula” for the free energy of an oscillator coupled to a heat bath [G. W. Ford, J. T. Lewis, and R. F. O’Connell, Phys. Rev. Lett. 55, 2273 (1985)]. A derivation of that formula from basic results of statistical mechanics and the independent oscillator model of a heat bath is presented.« less

Spatiotemporal variability and modeling of the solar irradiance transmissivity through a boreal forest

NASA Astrophysics Data System (ADS)

Nadeau, D.; Isabelle, P. E.; Asselin, M. H.; Parent, A. C.; Jutras, S.; Anctil, F.

2017-12-01

Solar irradiance is the largest driver of land-surface exchanges of energy, water and trace gases. Its absorption by a forest canopy generates considerable sensible and latent heat fluxes as well as tree temperature changes. A fraction of the irradiance gets transmitted through the canopy and powers another layer of energy fluxes, which can reach substantial values. Transmitted radiation is also of particular relevance to understory vegetation photosynthesis, snowpack energetics and soil temperature dynamics. Boreal forest canopy transmissivity needs to be quantified to properly reproduce land-atmosphere interactions in the circumpolar boreal biome, but its high spatiotemporal variability makes it a challenging task. The objective of this study is to characterize the spatiotemporal variability in under-canopy radiation and to evaluate the performance of various models in representing plot-scale observations. The study site is located in Montmorency Forest (47°N, 71°W), in southern Quebec, Canada. The vegetation includes mostly juvenile balsam firs, up to 6 to 8 m tall. Since January 2016, a 15-m flux tower measures the four components of radiation, as well as other relevant fluxes and meteorological variables, on a ≈10° northeast-facing slope. In summer 2016, 20 portable weather stations were mounted in a 150 m x 200 m grid around the flux tower. These stations were equipped with silicon-cell pyranometers and provided measurements of downwelling irradiance at a height of 2 m. This setup allowed us to compute irradiance transmissivity and to assess its spatiotemporal variability at the site. First, we show that the average of daily incoming energy varies tremendously across the sites, from 1 MJ/m2 to nearly 9 MJ/m2, due to large variations in canopy structure over short distances. Using a regression tree analysis, we show that transmissivity mostly depends on sun elevation, diffuse fraction of radiation, sky and sun view fraction and wind speed above canopy. We finally show that a simple Beer's law, describing the attenuation of light through a semi-transparent medium, does remarkably well at predicting the plot-scale transmissivity when driven with satellite-based leaf area index values.

Inter- and intrapatient variability of facial nerve response areas in the floor of the fourth ventricle.

PubMed

Bertalanffy, Helmut; Tissira, Nadir; Krayenbühl, Niklaus; Bozinov, Oliver; Sarnthein, Johannes

2011-03-01

Surgical exposure of intrinsic brainstem lesions through the floor of the 4th ventricle requires precise identification of facial nerve (CN VII) fibers to avoid damage. To assess the shape, size, and variability of the area where the facial nerve can be stimulated electrophysiologically on the surface of the rhomboid fossa. Over a period of 18 months, 20 patients were operated on for various brainstem and/or cerebellar lesions. Facial nerve fibers were stimulated to yield compound muscle action potentials (CMAP) in the target muscles. Using the sites of CMAP yield, a detailed functional map of the rhomboid fossa was constructed for each patient. Lesions resected included 14 gliomas, 5 cavernomas, and 1 epidermoid cyst. Of 40 response areas mapped, 19 reached the median sulcus. The distance from the obex to the caudal border of the response area ranged from 8 to 27 mm (median, 17 mm). The rostrocaudal length of the response area ranged from 2 to 15 mm (median, 5 mm). Facial nerve response areas showed large variability in size and position, even in patients with significant distance between the facial colliculus and underlying pathological lesion. Lesions located close to the facial colliculus markedly distorted the response area. This is the first documentation of variability in the CN VII response area in the rhomboid fossa. Knowledge of this remarkable variability may facilitate the assessment of safe entry zones to the brainstem and may contribute to improved outcome following neurosurgical interventions within this sensitive area of the brain.

A UV-to-MIR monitoring of DR Tau: Exploring how water vapor in the planet formation region is affected by stellar accretion variability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banzatti, A.; Meyer, M. R.; Manara, C. F.

2014-01-01

Young stars are known to show variability due to non-steady mass accretion rate from their circumstellar disks. Accretion flares can produce strong energetic irradiation and heating that may affect the disk in the planet formation region, close to the central star. During an extreme accretion outburst in the young star EX Lupi, the prototype of EXor variables, remarkable changes in molecular gas emission from ∼1 AU in the disk have recently been observed. Here, we focus on water vapor and explore how it is affected by variable accretion luminosity in T Tauri stars. We monitored a young highly variable solar-massmore » star, DR Tau, using simultaneously two high/medium-resolution spectrographs at the European Southern Observatory Very Large Telescope: VISIR at 12.4 μm to observe water lines from the disk and X-shooter covering from 0.3 to 2.5 μm to constrain the stellar accretion. Three epochs spanning timescales from several days to several weeks were obtained. The accretion luminosity was estimated to change within a factor of ∼2 and no change in water emission was detected at a significant level. In comparison with EX Lupi and EXor outbursts, DR Tau suggests that the less long-lived and weaker variability phenomena typical of T Tauri stars may leave water at planet-forming radii in the disk mostly unaffected. We propose that these systems may provide evidence for two processes that act over different timescales: ultraviolet photochemistry in the disk atmosphere (faster) and heating of the deeper disk layers (slower).« less

Zooplankton time-series in the Balearic Sea (Western Mediterranean): Variability during the decade 1994 2003

NASA Astrophysics Data System (ADS)

Fernández de Puelles, Maria Luz; Alemany, Francisco; Jansá, Javier

2007-08-01

Studies of plankton time-series from the Balearic islands waters are presented for the past decade, with main emphasis on the variability of zooplankton and how it relates to the environment. The seasonal and interannual patterns of temperature, salinity, nutrients, chlorophyll concentration and zooplankton abundance are described with data obtained between 1994 and 2003. Samples were collected every 10 days at a monitoring station in the Mallorca channel, an area with marked hydrographic variability in the Western Mediterranean. Mesoscale variability was also assessed using data from monthly sampling survey carried out between 1994 and 1999 in a three station transect located in the same study area. The copepods were the most abundant group with three higher peaks (March, May and September) distinguished during the annual cycle and a clear coastal-offshore decreasing gradient. Analysis of the zooplankton community revealed two distinct periods: the mixing period during winter and early spring, where copepods, siphonophores and ostracods were most abundant and, the stratified period characterised by an increase of cladocerans and meroplankton abundances. Remarkable interannual zooplankton variability was observed in relation to hydrographic regime with higher abundances of main groups during cool years, when northern Mediterranean waters prevailed in the area. The warmer years showed the lowest zooplankton abundances, associated with the inflow of less saline and nutrient-depleted Atlantic Waters. Moreover, the correlation found between copepod abundance and large scale climatic factors (e.g., NAO) suggested that they act as main driver of the zooplankton variability. Therefore, the seasonal but particularly the interannual variation observed in plankton abundance and structure patterns of the Balearic Sea seems to be highly modulated by large-scale forcing and can be considered an ideal place where to investigate potential consequences of global climate change.

Inter and intra-estuary variability in ingress, condition and settlement of the American eel Anguilla rostrata: implications for estimating and understanding recruitment.

PubMed

Sullivan, M C; Wuenschel, M J; Able, K W

2009-06-01

The objective of this study was to quantify spatial and temporal variability of anguillid glass eel ingress within and between adjacent watersheds in order to help illuminate the mechanisms moderating annual recruitment. Because single fixed locations are often used to assess annual recruitment, the intra-annual dynamics of ingress across multiple sites often remains unresolved. To address this question, plankton nets and eel collectors were deployed weekly to synoptically quantify early stage Anguilla rostrata abundance at 12 sites across two New Jersey estuaries over an ingress season. Numbers of early-stage glass eels collected at the inlet mouths were moderately variable within and between estuaries over time and showed evidence for weak lunar phase and water temperature correlations. The relative condition of glass eels, although highly variable, declined significantly over the ingress season and indicated a tendency for lower condition A. rostrata to colonize sites in the lower estuary. Accumulations of glass eels and early-stage elvers retrieved from collectors (one to >1500 A. rostrata per collector) at lower estuary sites were highly variable over time, producing only weak correlations between estuaries. By way of contrast, development into late-stage elvers, coupled with the large-scale colonization of up-river sites, was highly synchronized between and within estuaries and contingent on water temperatures reaching c. 10-12 degrees C. Averaged over the ingress season, abundance estimates were remarkably consistent between paired sites across estuaries, indicating a low degree of interestuary variability. Within an estuary, however, abundance estimates varied considerably depending on location. These results and methodology have important implications for the planning and interpretation of early-stage anguillid eel surveys as well as the understanding of the dynamic nature of ingress and the spatial scales over which recruitment varies.

Atypical Neural Processing of Ironic and Sincere Remarks in Children and Adolescents with Autism Spectrum Disorders

PubMed Central

Colich, Natalie L.; Wang, Audrey-Ting; Rudie, Jeffrey D.; Hernandez, Leanna M.; Bookheimer, Susan Y.; Dapretto, Mirella

2013-01-01

Individuals with ASD show consistent impairment in processing pragmatic language when attention to multiple social cues (e.g., facial expression, tone of voice) is often needed to navigate social interactions. Building upon prior fMRI work examining how facial affect and prosodic cues are used to infer a speaker's communicative intent, the authors examined whether children and adolescents with ASD differ from typically developing (TD) controls in their processing of sincere versus ironic remarks. At the behavioral level, children and adolescents with ASD and matched TD controls were able to determine whether a speaker's remark was sincere or ironic equally well, with both groups showing longer response times for ironic remarks. At the neural level, for both sincere and ironic scenarios, an extended cortical network—including canonical language areas in the left hemisphere and their right hemisphere counterparts—was activated in both groups, albeit to a lesser degree in the ASD sample. Despite overall similar patterns of activity observed for the two conditions in both groups, significant modulation of activity was detected when directly comparing sincere and ironic scenarios within and between groups. While both TD and ASD groups showed significantly greater activity in several nodes of this extended network when processing ironic versus sincere remarks, increased activity was largely confined to left language areas in TD controls, whereas the ASD sample showed a more bilateral activation profile which included both language and “theory of mind” areas (i.e., ventromedial prefrontal cortex). These findings suggest that, for high-functioning individuals with ASD, increased activity in right hemisphere homologues of language areas in the left hemisphere, as well as regions involved in social cognition, may reflect compensatory mechanisms supporting normative behavioral task performance. PMID:24497750

The interdecadal changes of south pacific sea surface temperature in the mid-1990s and their connections with ENSO

NASA Astrophysics Data System (ADS)

Li, Gang; Li, Chongyin; Tan, Yanke; Bai, Tao

2014-01-01

The characteristic changes of South Pacific sea surface temperature anomalies (SSTAs) for the period January 1979 to December 2011, during which the 1990s Pacific pan-decadal variability (PDV) interdecadal regime shifts occurred, were examined. Empirical Orthogonal Function (EOF) analysis was applied to the monthly mean SSTA for two sub-periods: January 1979 to December 1994 (P1) and January 1996 to December 2011 (P2). Both the spatial and temporal features of the leading EOF mode for P1 and P2 showed a remarkable difference. The spatial structure of the leading EOF changed from a tripolar pattern for P1 (EOF-P1) to a dipole-like pattern for P2 (EOF-P2). Besides, EOF-P1 (EOF-P2) had significant spectral peaks at 4.6 yr (2.7 yr). EOF-P2 not only had a closer association with El Niño-Southern Oscillation (ENSO), but also showed a faster response to ENSO than EOF-P1 based on their lead-lag relationships with ENSO. During the development of ENSO, the South Pacific SSTA associated with ENSO for both P1 and P2 showed a significant eastward propagation. However, after the peak of ENSO, EOF-P1 showed a stronger persistence than EOF-P2, which still showed eastward propagation. The variability of the SSTA associated with the whole process of ENSO evolution during P1 and the SSTA associated with the development of ENSO during P2 support the existence of ocean-to-atmosphere forcing, but the SSTA associated with the decay of ENSO shows the phenomenon of atmosphere-to-ocean forcing.

Hydrodynamic Trapping of Swimming Bacteria by Convex Walls

NASA Astrophysics Data System (ADS)

Sipos, O.; Nagy, K.; Di Leonardo, R.; Galajda, P.

2015-06-01

Swimming bacteria display a remarkable tendency to move along flat surfaces for prolonged times. This behavior may have a biological importance but can also be exploited by using microfabricated structures to manipulate bacteria. The main physical mechanism behind the surface entrapment of swimming bacteria is, however, still an open question. By studying the swimming motion of Escherichia coli cells near microfabricated pillars of variable size, we show that cell entrapment is also present for convex walls of sufficiently low curvature. Entrapment is, however, markedly reduced below a characteristic radius. Using a simple hydrodynamic model, we predict that trapped cells swim at a finite angle with the wall and a precise relation exists between the swimming angle at a flat wall and the critical radius of curvature for entrapment. Both predictions are quantitatively verified by experimental data. Our results demonstrate that the main mechanism for wall entrapment is hydrodynamic in nature and show the possibility of inhibiting cell adhesion, and thus biofilm formation, using convex features of appropriate curvature.

Prediction of binding poses to FXR using multi-targeted docking combined with molecular dynamics and enhanced sampling

NASA Astrophysics Data System (ADS)

Bhakat, Soumendranath; Åberg, Emil; Söderhjelm, Pär

2018-01-01

Advanced molecular docking methods often aim at capturing the flexibility of the protein upon binding to the ligand. In this study, we investigate whether instead a simple rigid docking method can be applied, if combined with multiple target structures to model the backbone flexibility and molecular dynamics simulations to model the sidechain and ligand flexibility. The methods are tested for the binding of 35 ligands to FXR as part of the first stage of the Drug Design Data Resource (D3R) Grand Challenge 2 blind challenge. The results show that the multiple-target docking protocol performs surprisingly well, with correct poses found for 21 of the ligands. MD simulations started on the docked structures are remarkably stable, but show almost no tendency of refining the structure closer to the experimentally found binding pose. Reconnaissance metadynamics enhances the exploration of new binding poses, but additional collective variables involving the protein are needed to exploit the full potential of the method.

Prediction of binding poses to FXR using multi-targeted docking combined with molecular dynamics and enhanced sampling.

PubMed

Bhakat, Soumendranath; Åberg, Emil; Söderhjelm, Pär

2018-01-01

Advanced molecular docking methods often aim at capturing the flexibility of the protein upon binding to the ligand. In this study, we investigate whether instead a simple rigid docking method can be applied, if combined with multiple target structures to model the backbone flexibility and molecular dynamics simulations to model the sidechain and ligand flexibility. The methods are tested for the binding of 35 ligands to FXR as part of the first stage of the Drug Design Data Resource (D3R) Grand Challenge 2 blind challenge. The results show that the multiple-target docking protocol performs surprisingly well, with correct poses found for 21 of the ligands. MD simulations started on the docked structures are remarkably stable, but show almost no tendency of refining the structure closer to the experimentally found binding pose. Reconnaissance metadynamics enhances the exploration of new binding poses, but additional collective variables involving the protein are needed to exploit the full potential of the method.

The Physics Of The 'Heartbeat' State Of The Microquasar GRS 1915+105

NASA Astrophysics Data System (ADS)

Neilsen, Joseph; Lee, J. C.; Remillard, R.

2010-03-01

Approaching the 14th anniversary of the first observations of GRS 1915+105 with RXTE, we present new results from a joint RXTE/Chandra study of the remarkable X-ray spectral variability of this enigmatic microquasar. For the first time, we are able to show that changes in the broadband X-ray spectrum (RXTE) on timescales of seconds are associated with changes in absorption lines (Chandra HETGS) from the accretion disk wind, leading to new insights about accretion and ejection around the black hole. We will play a real-time movie of our X-ray data showing the black hole attempting and failing to launch a jet, driving a wind from the accretion disk, and finally ejecting the entire inner accretion flow into the corona, all in a bizarre cycle that repeats for days but lasts fewer than 60 seconds. We use these phenomena to probe the ionizing influence of the inner accretion flow on the environment of the black hole.

Political complexity predicts the spread of ethnolinguistic groups

PubMed Central

Currie, Thomas E.; Mace, Ruth

2009-01-01

Human languages show a remarkable degree of variation in the area they cover. However, the factors governing the distribution of human cultural groups such as languages are not well understood. While previous studies have examined the role of a number of environmental variables the importance of cultural factors has not been systematically addressed. Here we use a geographical information system (GIS) to integrate information about languages with environmental, ecological, and ethnographic data to test a number of hypotheses that have been proposed to explain the global distribution of languages. We show that the degree of political complexity and type of subsistence strategy exhibited by societies are important predictors of the area covered by a language. Political complexity is also strongly associated with the latitudinal gradient in language area, whereas subsistence strategy is not. We argue that a process of cultural group selection favoring more complex societies may have been important in shaping the present-day global distribution of language diversity. PMID:19380740

Linking animal-borne video to accelerometers reveals prey capture variability

PubMed Central

Watanabe, Yuuki Y.; Takahashi, Akinori

2013-01-01

Understanding foraging is important in ecology, as it determines the energy gains and, ultimately, the fitness of animals. However, monitoring prey captures of individual animals is difficult. Direct observations using animal-borne videos have short recording periods, and indirect signals (e.g., stomach temperature) are never validated in the field. We took an integrated approach to monitor prey captures by a predator by deploying a video camera (lasting for 85 min) and two accelerometers (on the head and back, lasting for 50 h) on free-swimming Adélie penguins. The movies showed that penguins moved the heads rapidly to capture krill in midwater and fish (Pagothenia borchgrevinki) underneath the sea ice. Captures were remarkably fast (two krill per second in swarms) and efficient (244 krill or 33 P. borchgrevinki in 78–89 min). Prey captures were detected by the signal of head acceleration relative to body acceleration with high sensitivity and specificity (0.83–0.90), as shown by receiver-operating characteristic analysis. Extension of signal analysis to the entire behavioral records showed that krill captures were spatially and temporally more variable than P. borchgrevinki captures. Notably, the frequency distribution of krill capture rate closely followed a power-law model, indicating that the foraging success of penguins depends on a small number of very successful dives. The three steps illustrated here (i.e., video observations, linking video to behavioral signals, and extension of signal analysis) are unique approaches to understanding the spatial and temporal variability of ecologically important events such as foraging. PMID:23341596

Effects of variability in probable maximum precipitation patterns on flood losses

NASA Astrophysics Data System (ADS)

Zischg, Andreas Paul; Felder, Guido; Weingartner, Rolf; Quinn, Niall; Coxon, Gemma; Neal, Jeffrey; Freer, Jim; Bates, Paul

2018-05-01

The assessment of the impacts of extreme floods is important for dealing with residual risk, particularly for critical infrastructure management and for insurance purposes. Thus, modelling of the probable maximum flood (PMF) from probable maximum precipitation (PMP) by coupling hydrological and hydraulic models has gained interest in recent years. Herein, we examine whether variability in precipitation patterns exceeds or is below selected uncertainty factors in flood loss estimation and if the flood losses within a river basin are related to the probable maximum discharge at the basin outlet. We developed a model experiment with an ensemble of probable maximum precipitation scenarios created by Monte Carlo simulations. For each rainfall pattern, we computed the flood losses with a model chain and benchmarked the effects of variability in rainfall distribution with other model uncertainties. The results show that flood losses vary considerably within the river basin and depend on the timing and superimposition of the flood peaks from the basin's sub-catchments. In addition to the flood hazard component, the other components of flood risk, exposure, and vulnerability contribute remarkably to the overall variability. This leads to the conclusion that the estimation of the probable maximum expectable flood losses in a river basin should not be based exclusively on the PMF. Consequently, the basin-specific sensitivities to different precipitation patterns and the spatial organization of the settlements within the river basin need to be considered in the analyses of probable maximum flood losses.

Prediction of ozone concentration in tropospheric levels using artificial neural networks and support vector machine at Rio de Janeiro, Brazil

NASA Astrophysics Data System (ADS)

Luna, A. S.; Paredes, M. L. L.; de Oliveira, G. C. G.; Corrêa, S. M.

2014-12-01

It is well known that air quality is a complex function of emissions, meteorology and topography, and statistical tools provide a sound framework for relating these variables. The observed data were contents of nitrogen dioxide (NO2), nitrogen monoxide (NO), nitrogen oxides (NOx), carbon monoxide (CO), ozone (O3), scalar wind speed (SWS), global solar radiation (GSR), temperature (TEM), moisture content in the air (HUM), collected by a mobile automatic monitoring station at Rio de Janeiro City in two places of the metropolitan area during 2011 and 2012. The aims of this study were: (1) to analyze the behavior of the variables, using the method of PCA for exploratory data analysis; (2) to propose forecasts of O3 levels from primary pollutants and meteorological factors, using nonlinear regression methods like ANN and SVM, from primary pollutants and meteorological factors. The PCA technique showed that for first dataset, variables NO, NOx and SWS have a greater impact on the concentration of O3 and the other data set had the TEM and GSR as the most influential variables. The obtained results from the nonlinear regression techniques ANN and SVM were remarkably closely and acceptable to one dataset presenting coefficient of determination for validation respectively 0.9122 and 0.9152, and root mean square error of 7.66 and 7.85, respectively. For these datasets, the PCA, SVM and ANN had demonstrated their robustness as useful tools for evaluation, and forecast scenarios for air quality.

Discussion on selected symbiotic stars

NASA Technical Reports Server (NTRS)

Viotti, Roberto; Hack, Margherita

1993-01-01

Because of its large variety of aspects, the symbiotic phenomenon is not very suitable for a statistical treatment. It is also not clear whether symbiotic stars really represent a homogeneous group of astrophysical objects or a collection of objects of different natures but showing similar phenomena. However we are especially interested in the symbiotic phenomenon, i.e., in those physical processes occurring in the atmosphere of each individual object and in their time dependence. Such a research can be performed through the detailed analysis of individual objects. This study should be done for a time long enough to cover all the different phases of their activity, in all the spectral ranges. Since the typical time scale of the symbiotic phenomena is up to several years and decades, this represents a problem since, for instance, making astronomy outside the visual region is a quite new field of research. It was a fortunate case that a few symbiotic stars (Z And, AG Dra, CH Cyg, AX Per, and PU Vul) had undergone remarkable light variations (or 'outbursts') in recent years, which could have been followed in the space ultraviolet with IUE, and simultaneously in the optical and IR with ground-based telescopes. But, in general, the time coverage of most of the symbiotic objects is too short to have a complete picture of their behavior. In this regard, one should recall Mayall's remark about the light curve of Z And: 'Z Andromedae is another variable that shows it will require several hundred years of observations before a good analysis can be made of its variations'. This pessimistic remark should be considered as a note of caution for those involved in the interpretation of the observations. We shall discuss a number of individual symbiotic stars for which the amount of observational data is large enough to draw a rather complete picture of their general behavior and to make consistent models. We shall especially illustrate the necessary steps toward an empirical model and take the discussion of the individual objects as a useful occasion to describe different techniques of diagnosis.

Improving multivariate Horner schemes with Monte Carlo tree search

NASA Astrophysics Data System (ADS)

Kuipers, J.; Plaat, A.; Vermaseren, J. A. M.; van den Herik, H. J.

2013-11-01

Optimizing the cost of evaluating a polynomial is a classic problem in computer science. For polynomials in one variable, Horner's method provides a scheme for producing a computationally efficient form. For multivariate polynomials it is possible to generalize Horner's method, but this leaves freedom in the order of the variables. Traditionally, greedy schemes like most-occurring variable first are used. This simple textbook algorithm has given remarkably efficient results. Finding better algorithms has proved difficult. In trying to improve upon the greedy scheme we have implemented Monte Carlo tree search, a recent search method from the field of artificial intelligence. This results in better Horner schemes and reduces the cost of evaluating polynomials, sometimes by factors up to two.

Eosinophilic panniculitis.

PubMed

Samlaska, C P; de Lorimier, A J; Heldman, L S

1995-03-01

Eosinophillic panniculitis is a poorly defined entity with variable clinical features. We report a case of rapidly enlarging, asymptomatic subcutaneous scalp nodules in a 6-year-old black boy with atopic dermatitis. The nodules resolved spontaneously over two to three days. Biopsy specimens were remarkable for eosinophilic panniculitis without evidence of epidermal change or vasculitis. We believe that this is the youngest reported patient with this disorder.

The Relation between English Learning Students' Levels of Self-Regulation and Metacognitive Skills and Their English Academic Achievements

ERIC Educational Resources Information Center

Adigüzel, Abdullah; Orhan, Ali

2017-01-01

It is remarkable that there are only a few studies that measures to what extent metacognitive and self-regulation skills affect students' academic achievements in the English lesson. This study is important for identifying the personal variables that have an impact on metacognitive and self-regulation skill and determining the relationship between…

Small-scale variability of zooplankton pyruvate kinase activity in the Gironde Estuary plume (Atlantic French Coast): A case study under unusually low freshwater discharge

NASA Astrophysics Data System (ADS)

Bergeron, Jean-Pierre

2006-09-01

Pyruvate kinase (PK) activity measurements are used to assess the role of carbohydrates in global feeding of mesozooplankton communities inhabiting an estuary plume. As a consequence of a remarkably low freshwater discharge rate, the sea surface layers of the area under estuarine influence showed a very moderate salinity fall and a nearly total depletion in nitrates, whereas higher levels of these nutrients were found in deeper, more saline, layers. Small-scale PK activity variations in mesozooplankton appear to be closely correlated to nitrate integration values within the water column. The results were analysed in comparison with literature reports. The study produced a coherent overall interpretation, which strongly supports the reliability of this new biochemical tool in detecting assimilation of trace carbohydrates in the diet of mesozooplankton.

Symmetric polynomials in information theory: Entropy and subentropy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jozsa, Richard; Mitchison, Graeme

2015-06-15

Entropy and other fundamental quantities of information theory are customarily expressed and manipulated as functions of probabilities. Here we study the entropy H and subentropy Q as functions of the elementary symmetric polynomials in the probabilities and reveal a series of remarkable properties. Derivatives of all orders are shown to satisfy a complete monotonicity property. H and Q themselves become multivariate Bernstein functions and we derive the density functions of their Levy-Khintchine representations. We also show that H and Q are Pick functions in each symmetric polynomial variable separately. Furthermore, we see that H and the intrinsically quantum informational quantitymore » Q become surprisingly closely related in functional form, suggesting a special significance for the symmetric polynomials in quantum information theory. Using the symmetric polynomials, we also derive a series of further properties of H and Q.« less

Effect of impurities of selenium and iron on the Anderson localization of 1T-TaS 2

NASA Astrophysics Data System (ADS)

Ōnuki, Y.; Inada, R.; Tanuma, S.

1980-01-01

The temperature dependence of electrical resistivities θ( T) of 1T-TaS 2, 1T-TaS 2- xSe x and 1T-Fe xTa 1- xS 2 is found to be θ( T) ∝ exp( T0/ T) 1/n in the temperature range of 4 K to the measured lowest temperature, 0.1 K, showing the variable range hopping of Anderson localized states. The n-value is nearly 3 for selenium doping and nearly 2 for non-doping and iron doping. The positive magnetoresistance, which is sizable only in the temperature range of 2 K to 0.5 K in 1T-TaS 2, is found to be remarkably enhanced by the selenium doping, while the tendency is reversed by the iron doping.

Accident data study of concrete construction companies' similarities and differences between qualified and non-qualified workers in Spain.

PubMed

López-Arquillos, Antonio; Rubio-Romero, Juan Carlos; Gibb, Alistair

2015-01-01

The aim of this paper is to discuss findings from an analysis of accidents in concrete construction companies in Spain and to compare the accident rates of qualified and non-qualified workers. A total of 125,021 accidents between 2003 and 2008 involving both blue-collar and white-collar workers were analysed, comparing the variables of occupation, age, company staff, length of service, location of the accident, together with the severity of the accidents. Results showed that lack of experience in the first month is more significant in non-qualified workers and experienced supervisors and that head injuries are more likely to lead to fatalities. The most remarkable similarity was that fatal accidents to and from the worksite are a problem common to both groups of workers.

Spatio-temporal variability of modern sedimentation rates in Lake Nam Co, central Tibetan Plateau, China -- the first results from sediment traps

NASA Astrophysics Data System (ADS)

Wang, J.; Ju, J.; Daut, G.; Wang, Y.; Maeusbacher, R.; Zhu, L.

2013-12-01

As a big and deep lake in high altitude environment, Nam Co has played an important role in the past decade concerning paleoenvironmental change study. However, the modern process monitoring research is still insufficient in this lake to understand the variations in the modern sedimentation patterns. Sediment traps are widely used in lakes monitoring and research, providing the modern sedimentation rates (SR) and flux information as well as the materials for multidisciplinary studies. Here we present the first and preliminary result of spatio-temporal variability of SR in Nam Co based on one-year sediment traps data. Three integrated self-made traps mooring were deployed in different areas in Nam Co, which were eastern area (T1, ~57m depth), middle area (T2, ~93m depth) and western area (T3, ~62m depth). There were three layers traps in T1 and T3 station while four layers in T2 station. Additionally, a time-series automatic samples changing trap (Technicap PPS 3/3, France) was set up in the bottom (~90m depth) of T2 station with a sampling interval of two weeks. All traps were established in late May, 2012 and collected in Mid-September, 2012 for the first time. Then after winter time, samples were again collected in late May, 2013. Therefore, we got results for two periods, namely summer half year (May-September) and winter half year (September-next May). The results showed remarkable variation of SR vertically in all three stations, the bottom layers received much more materials than the up and middle layers. This fact could be attributed to the distinct influence of high density flows occurring at the lake bottom. This is also supported by multiprobe measurements showing high turbidity in the water body close to the bottom. In shallow areas (T1 and T3) the SR were higher than that of deep area (T2), which could probably reflect the different distance from the terrestrial source to the sites where the traps were deployed. In T1 and T2 stations, SR of winter half year (calculated as mg/cm2/day) was much higher than summer half year and this trend was also partly detected in the time-series sediment trap (T2), which showed higher SR in October, November and early June (no data from December to May). From early June to mid-November, the average SR of T2 station (~90m depth) ranged 0.09-0.95 mg/cm2/day, showed a remarkable temporal variation. More data and detailed analysis are still needed to elucidate the variability of modern SR in Nam Co and the influencing factors, including some internal mechanisms and outside driving related to climate change.

Directional selection in temporally replicated studies is remarkably consistent.

PubMed

Morrissey, Michael B; Hadfield, Jarrod D

2012-02-01

Temporal variation in selection is a fundamental determinant of evolutionary outcomes. A recent paper presented a synthetic analysis of temporal variation in selection in natural populations. The authors concluded that there is substantial variation in the strength and direction of selection over time, but acknowledged that sampling error would result in estimates of selection that were more variable than the true values. We reanalyze their dataset using techniques that account for the necessary effect of sampling error to inflate apparent levels of variation and show that directional selection is remarkably constant over time, both in magnitude and direction. Thus we cannot claim that the available data support the existence of substantial temporal heterogeneity in selection. Nonetheless, we conject that temporal variation in selection could be important, but that there are good reasons why it may not appear in the available data. These new analyses highlight the importance of applying techniques that estimate parameters of the distribution of selection, rather than parameters of the distribution of estimated selection (which will reflect both sampling error and "real" variation in selection); indeed, despite availability of methods for the former, focus on the latter has been common in synthetic reviews of the aspects of selection in nature, and can lead to serious misinterpretations. © 2011 The Author(s). Evolution© 2011 The Society for the Study of Evolution.

Monogamy relation in multipartite continuous-variable quantum teleportation

NASA Astrophysics Data System (ADS)

Lee, Jaehak; Ji, Se-Wan; Park, Jiyong; Nha, Hyunchul

2016-12-01

Quantum teleportation (QT) is a fundamentally remarkable communication protocol that also finds many important applications for quantum informatics. Given a quantum entangled resource, it is crucial to know to what extent one can accomplish the QT. This is usually assessed in terms of output fidelity, which can also be regarded as an operational measure of entanglement. In the case of multipartite communication when each communicator possesses a part of an N -partite entangled state, not all pairs of communicators can achieve a high fidelity due to the monogamy property of quantum entanglement. We here investigate how such a monogamy relation arises in multipartite continuous-variable (CV) teleportation, particularly when using a Gaussian entangled state. We show a strict monogamy relation, i.e., a sender cannot achieve a fidelity higher than optimal cloning limit with more than one receiver. While this seems rather natural owing to the no-cloning theorem, a strict monogamy relation still holds even if the sender is allowed to individually manipulate the reduced state in collaboration with each receiver to improve fidelity. The local operations are further extended to non-Gaussian operations such as photon subtraction and addition, and we demonstrate that the Gaussian cloning bound cannot be beaten by more than one pair of communicators. Furthermore, we investigate a quantitative form of monogamy relation in terms of teleportation capability, for which we show that a faithful monogamy inequality does not exist.

Interannual Variations In the Low-Degree Components of the Geopotential derived from SLR and the Connections With Geophysical/Climatic Processes

NASA Technical Reports Server (NTRS)

Chao, Benjamin F.; Cox, Christopher M.; Au, Andrew Y.

2004-01-01

Recent Satellite Laser Ranging derived long wavelength gravity time series analysis has focused to a large extent on the effects of the recent large changes in the Earth s 52, and the potential causes. However, it is difficult to determine whether there are corresponding signals in the shorter wavelength zonals from the existing SLR-derived time variable gravity results, although it appears that geophysical fluid transport is being observed. For example, the recovered J3 time series shows remarkable agreement with NCEP-derived estimates of atmospheric gravity variations. Likewise, some of the non-zonal spherical harmonic coefficient series have significant interannual signal that appears to be related to mass transport. The non-zonal degree 2 terms show reasonable correlation with atmospheric signals, as well as climatic effects such as El Nino Southern Oscillation. While the formal uncertainty of these terms is significantly higher than that for J2, it is also clear that there is useful signal to be extracted. Consequently, the SLR time series is being reprocessed to improve the time variable gravity field recovery. We will present recent updates on the J2 evolution, as well as a look at other components of the interannual variations of the gravity field, complete through degree 4, and possible geophysical and climatic causes.

Albanian violets of the section Melanium, their morphological variability, genetic similarity and their adaptations to serpentine or chalk soils.

PubMed

Słomka, Aneta; Godzik, Barbara; Szarek-Łukaszewska, Grażyna; Shuka, Lulëzim; Hoef-Emden, Kerstin; Bothe, Hermann

2015-02-01

Violets of the section Melanium from Albanian serpentine and chalk soils were examined for their taxonomic affiliations, their ability to accumulate heavy metals and their colonization by arbuscular mycorrhizal fungi (AMF). The sequence analysis of the ITS1-5.8S rDNA-ITS2 region showed that all the sampled six Albanian violets grouped between Viola lutea and Viola arvensis, but not with Viola tricolor. The fine resolution of the ITS sequences was not sufficient for a further delimitation of the Albanian violets within the V. lutea-V. arvensis clade. Therefore, the Albanian violets were classified by a set of morphological characters. Viola albanica, Viola dukadjinica and Viola raunsiensis from serpentine soils as well as Viola aetolica from a chalk meadow were unambiguously identified, whereas the samples of Viola macedonica showed high morphological variability. All the violets, in both roots and shoots contained less than or similar levels of heavy metals as their harboring soils, indicating that they were heavy metal excluders. All the violets were strongly colonized by AMF with the remarkable exception of V. albanica. This violet lived as a scree creeper in shallow serpentine soil where the concentration of heavy metals was high but those of P, K and N were scarce. Copyright © 2014 Elsevier GmbH. All rights reserved.

Robustness of a rhythmic circuit to short- and long-term temperature changes.

PubMed

Tang, Lamont S; Taylor, Adam L; Rinberg, Anatoly; Marder, Eve

2012-07-18

Recent computational and experimental work has shown that similar network performance can result from variable sets of synaptic and intrinsic properties. Because temperature is a global perturbation that differentially influences every biological process within the nervous system, one might therefore expect that individual animals would respond differently to temperature. Nonetheless, the phase relationships of the pyloric rhythm of the stomatogastric ganglion (STG) of the crab, Cancer borealis, are remarkably invariant between 7 and 23°C (Tang et al., 2010). Here, we report that, when isolated STG preparations were exposed to more extreme temperature ranges, their networks became nonrhythmic, or "crashed", in a reversible fashion. Animals were acclimated for at least 3 weeks at 7, 11, or 19°C. When networks from the acclimated animals were perturbed by acute physiologically relevant temperature ramps (11-23°C), the network frequency and phase relationships were independent of the acclimation group. At high acute temperatures (>23°C), circuits from the cold-acclimated animals produced less-regular pyloric rhythms than those from warm-acclimated animals. At high acute temperatures, phase relationships between pyloric neurons were more variable from animal to animal than at moderate acute temperatures, suggesting that individual differences across animals in intrinsic circuit parameters are revealed at high temperatures. This shows that individual and variable neuronal circuits can behave similarly in normal conditions, but their behavior may diverge when confronted with extreme external perturbations.

A meshless method for solving two-dimensional variable-order time fractional advection-diffusion equation

NASA Astrophysics Data System (ADS)

Tayebi, A.; Shekari, Y.; Heydari, M. H.

2017-07-01

Several physical phenomena such as transformation of pollutants, energy, particles and many others can be described by the well-known convection-diffusion equation which is a combination of the diffusion and advection equations. In this paper, this equation is generalized with the concept of variable-order fractional derivatives. The generalized equation is called variable-order time fractional advection-diffusion equation (V-OTFA-DE). An accurate and robust meshless method based on the moving least squares (MLS) approximation and the finite difference scheme is proposed for its numerical solution on two-dimensional (2-D) arbitrary domains. In the time domain, the finite difference technique with a θ-weighted scheme and in the space domain, the MLS approximation are employed to obtain appropriate semi-discrete solutions. Since the newly developed method is a meshless approach, it does not require any background mesh structure to obtain semi-discrete solutions of the problem under consideration, and the numerical solutions are constructed entirely based on a set of scattered nodes. The proposed method is validated in solving three different examples including two benchmark problems and an applied problem of pollutant distribution in the atmosphere. In all such cases, the obtained results show that the proposed method is very accurate and robust. Moreover, a remarkable property so-called positive scheme for the proposed method is observed in solving concentration transport phenomena.

Some preliminary results from the NWTC direct-drive, variable-speed test bed

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlin, P.W.; Fingersh, L.J.

1996-10-01

With the remarkable rise in interest in variable-speed operation of larger wind turbines, it has become important for the National Wind Technology Center (NWTC) to have access to a variable-speed test bed that can be specially instrumented for research. Accordingly, a three-bladed, 10-meter, downwind, Grumman Windstream machine has been equipped with a set of composite blades and a direct-coupled, permanent-magnet, 20 kilowatt generator. This machine and its associated control system and data collection system are discussed. Several variations of a maximum power control algorithm have been installed on the control computer. To provide a baseline for comparison, several constant speedmore » algorithms have also been installed. The present major effort is devoted to daytime, semi-autonomous data collection.« less

Constraining Dust Hazes at the L/T Transition via Variability

NASA Astrophysics Data System (ADS)

Radigan, Jacqueline; Apai, Daniel; Yang, Hao; Hiranaka, Kay; Cruz, Kelle; Buenzli, Esther; Marley, Mark

2014-12-01

The T2 dwarf SIMP 1629+03 is a variable L/T transition dwarf, with a normal near-infrared spectrum. However, it is remarkable in that the wavelength dependence of its variability differs markedly from that of other L/T transition brown dwarfs. In particular, the absence of a water absorption feature in its variability spectrum indicates that a patchy, high-altitude haze, rather than a deeper cloud layer is responsible for the observed variations. We propose to obtain Spitzer+HST observations of SIMP1629+02 over two consecutive rotations periods in order to simultaneously map it?s spectral variability across 1-5 um. The wide wavelength coverage will provide a suitable lever-arm for constraining the particle size distribution in the haze. A truly flat spectrum across this wavelength range would indicate large particle sizes in comparison to those inferred for red L-dwarf hazes, and would therefore provide direct evidence of grain growth with decreasing effective temperature and/or a grain-size dependence on surface gravity in brown dwarf atmospheres.

Epidemiological, clinical, microbiological and therapeutic differences in tuberculosis disease in patients with and without HIV infection.

PubMed

Martínez-Sanz, Javier; Lago-Gómez, María Rosa; Rodríguez-Zurita, María Elena; Martín-Echevarría, Esteban; Torralba, Miguel

2018-04-23

Our objective is to analyze the incidence of tuberculosis (TB) in our population and to compare the characteristics of patients with and without HIV infection. Clinical-epidemiological retrospective cohort study that included patients diagnosed with TB with and without HIV infection between 2005-2016 in the province of Guadalajara (Spain). Epidemiological, clinical, microbiological and therapeutic variables were assessed, including microbiological resistances. TB was diagnosed in 261 patients. There were 25 patients (9.6%) who had HIV infection. Patients with HIV infection were predominantly males, had higher incidence of hepatitis C virus, a higher percentage of extrapulmonary TB, a higher prevalence of resistance to isoniazid and rifampicin, a greater paradoxical response and a longer average hospital stay. On the other hand, they had a lower percentage of positive tuberculin skin test and positive sputum smear (microscopy). A significant percentage of TB patients had no serology for HIV. Patients with HIV infection show remarkable differences in epidemiological, clinical and resistance variables to antituberculosis drugs. A high percentage of patients with TB were not tested for HIV. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

The effect of Malaysia general election on stock market returns.

PubMed

Liew, Venus Khim-Sen; Rowland, Racquel

2016-01-01

During the latest episode of general election held in Malaysia, it is observed that the FBMKLCI index was lifted 62.52 points in a day soon after the announcement of election outcome. Moreover, the index registered a highest gain of 96.29 points in the middle of the intra-day trade. This suggests that investors who had got the right direction could make profitable intra-day trading the next trading day of the general election date. Results from statistical analysis uncover significant before-election-effect and after-election-effect from the most recent general elections held in Malaysia. Different subsets of macroeconomic variables are found to have significant role on stock market return depending on the market situation. Remarkably, when there was close fight between the two major political parties during the 2008 and 2013 election years, political uncertainty showed up its negative and significant role in influencing the stock market return. The major implication of these findings is that while investors may seek abnormal returns before and after the next general election, which is around the corner, they will have to pay attention on the influence of macroeconomic variables and political uncertainty on stock market return during the election year.

Does linguistic input play the same role in language learning for children with and without early brain injury?

PubMed

Rowe, Meredith L; Levine, Susan C; Fisher, Joan A; Goldin-Meadow, Susan

2009-01-01

Children with unilateral pre- or perinatal brain injury (BI) show remarkable plasticity for language learning. Previous work highlights the important role that lesion characteristics play in explaining individual variation in plasticity in the language development of children with BI. The current study examines whether the linguistic input that children with BI receive from their caregivers also contributes to this early plasticity, and whether linguistic input plays a similar role in children with BI as it does in typically developing (TD) children. Growth in vocabulary and syntactic production is modeled for 80 children (53 TD, 27 BI) between 14 and 46 months. Findings indicate that caregiver input is an equally potent predictor of vocabulary growth in children with BI and in TD children. In contrast, input is a more potent predictor of syntactic growth for children with BI than for TD children. Controlling for input, lesion characteristics (lesion size, type, seizure history) also affect the language trajectories of children with BI. Thus, findings illustrate how both variability in the environment (linguistic input) and variability in the organism (lesion characteristics) work together to contribute to plasticity in language learning.

Shape-shifting corals: Molecular markers show morphology is evolutionarily plastic in Porites

PubMed Central

Forsman, Zac H; Barshis, Daniel J; Hunter, Cynthia L; Toonen, Robert J

2009-01-01

Background Corals are notoriously difficult to identify at the species-level due to few diagnostic characters and variable skeletal morphology. This 'coral species problem' is an impediment to understanding the evolution and biodiversity of this important and threatened group of organisms. We examined the evolution of the nuclear ribosomal internal transcribed spacer (ITS) and mitochondrial markers (COI, putative control region) in Porites, one of the most taxonomically challenging and ecologically important genera of reef-building corals. Results Nuclear and mitochondrial markers were congruent, clearly resolving many traditionally recognized species; however, branching and mounding varieties were genetically indistinguishable within at least two clades, and specimens matching the description of 'Porites lutea' sorted into three genetically divergent groups. Corallite-level features were generally concordant with genetic groups, although hyper-variability in one group (Clade I) overlapped and obscured several others, and Synarea (previously thought to be a separate subgenus) was closely related to congeners despite its unique morphology. Scanning electron microscopy revealed subtle differences between genetic groups that may have been overlooked previously as taxonomic characters. Conclusion This study demonstrates that the coral skeleton can be remarkably evolutionarily plastic, which may explain some taxonomic difficulties, and obscure underlying patterns of endemism and diversity. PMID:19239678

Hydro-mechanical properties of the Red Salt Clay (T4) - Relevancy of the minimum stress criterion for barrier integrity

NASA Astrophysics Data System (ADS)

Minkley, W.; Popp, T.; Salzer, K.; Gruner, M.; Böttge, V.

The so-called Red Salt Clay (T4) is deposited as clay-rich clastic sediment at the base of the Aller-series forming a persistent lateral layer of up to 20 m thickness above the lower Zechstein-series. The clay layers may act as a protective shield in the hanging wall of gas storages or underground repositories in salt formations, thus resulting in a multi-barrier system. As a proof of its reliability comprehensive hydro-mechanical investigations were performed on clay samples recovered at different sites in Germany. Most important, rock tightness against various fluids was confirmed in the lab and field-scale. Remarkably, only if the fluid pressure equalises the acting minimal stress (i.e. violence of the “minimum stress criterion”) a significant increase of permeability is observed (“pathway dilatation”) but no macro-frac. However, the material properties from different locations showed a significant variability according to different burial depths. Thus the Red Salt Clay may act as natural analogue, representing the material variability of various indurated clays. In addition, the existing knowledge gained from practical mining activities can be used to evaluate extreme in situ loading conditions.

Scale size-dependent characteristics of the nightside aurora

NASA Astrophysics Data System (ADS)

Humberset, B. K.; Gjerloev, J. W.; Samara, M.; Michell, R. G.

2017-02-01

We have determined the spatiotemporal characteristics of the magnetosphere-ionosphere (M-I) coupling using auroral imaging. Observations at fixed positions for an extended period of time are provided by a ground-based all-sky imager measuring the 557.7 nm auroral emissions. We report on a single event of nightside aurora (˜22 magnetic local time) preceding a substorm onset. To determine the spatiotemporal characteristics, we perform an innovative analysis of an all-sky imager movie (19 min duration, images at 3.31 Hz) that combines a two-dimensional spatial fast Fourier transform with a temporal correlation. We find a scale size-dependent variability where the largest scale sizes are stable on timescales of minutes while the small scale sizes are more variable. When comparing two smaller time intervals of different types of auroral displays, we find a variation in their characteristics. The characteristics averaged over the event are in remarkable agreement with the spatiotemporal characteristics of the nightside field-aligned currents during moderately disturbed times. Thus, two different electrodynamical parameters of the M-I coupling show similar behavior. This gives independent support to the claim of a system behavior that uses repeatable solutions to transfer energy and momentum from the magnetosphere to the ionosphere.

Barcoding and species recognition of opportunistic pathogens in Ochroconis and Verruconis.

PubMed

Samerpitak, Kittipan; Gerrits van den Ende, Bert H G; Stielow, J Benjamin; Menken, Steph B J; de Hoog, G Sybren

2016-02-01

The genera Ochroconis and Verruconis (Sympoventuriaceae, Venturiales) have remarkably high molecular diversity despite relatively high degrees of phenotypic similarity. Tree topologies, inter-specific and intra-specific heterogeneities, barcoding gaps and reciprocal monophyly of all currently known species were analyzed. It was concluded that all currently used genes viz. SSU, ITS, LSU, ACT1, BT2, and TEF1 were unable to reach all 'gold standard' criteria of barcoding markers. They could nevertheless be used for reasonably reliable identification of species, because the markers, although variable, were associated with large inter-specific heterogeneity. Of the coding protein-genes, ACT1 revealed highest potentiality as barcoding marker in mostly all parts of the investigated sequence. SSU, LSU, ITS, and ACT1 yielded consistent monophyly in all investigated species, but only SSU and LSU generated clear barcoding gaps. For phylogeny, LSU was an informative marker, suitable to reconstruct gene-trees showing correct phylogenetic relationships. Cryptic species were revealed especially in complexes with very high intra-specific variability. When all these complexes will be taxonomically resolved, ACT1 will probably appear to be the most reliable barcoding gene for Ochroconis and Verruconis. Copyright © 2015 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

Genetic and phenotypic variability of iris color in Buenos Aires population

PubMed Central

Hohl, Diana María; Bezus, Brenda; Ratowiecki, Julia; Catanesi, Cecilia Inés

2018-01-01

Abstract The aim of this work was to describe the phenotypic and genotypic variability related to iris color for the population of Buenos Aires province (Argentina), and to assess the usefulness of current methods of analysis for this country. We studied five Single Nucleotide Polymorphisms (SNPs) included in the IrisPlex kit, in 118 individuals, and we quantified eye color with Digital Iris Analysis Tool. The markers fit Hardy-Weinberg equilibrium for the whole sample, but not for rs12913832 within the group of brown eyes (LR=8.429; p=0.004). We found a remarkable association of HERC2 rs12913832 GG with blue color (p < 0.01) but the other markers did not show any association with iris color. The results for the Buenos Aires population differ from those of other populations of the world for these polymorphisms (p < 0,01). The differences we found might respond to the admixed ethnic composition of Argentina; therefore, methods of analysis used in European populations should be carefully applied when studying the population of Argentina. These findings reaffirm the importance of this investigation in the Argentinian population for people identification based on iris color. PMID:29658972

Sexuality during pregnancy and after childbirth: a metacontent analysis of 59 studies.

PubMed

von Sydow, K

1999-07-01

The aim of this study is to gain a systematic overview of all existing studies on parental sexuality during pregnancy and the postpartum period (months 1-6). Investigations of psychological and medical data banks and cross-references revealed 59 relevant studies published in English or German between 1950 and 1996. These primary studies were metacontent analyzed, according to the following categories: methodology (samples, designs): type of descriptive data researched (sexual activity, interest, enjoyment, orgasm, problems); and type of correlational data researched (sexual variables and pregnancy outcome, maternal physical and psychological health, sociodemographic data, biographical data, partnership data). On average, female sexual interest and coital activity declines slightly in the first trimester of pregnancy, shows variable patterns in the second trimester, and decreases sharply in the third trimester. Most couples do not practice intercourse for about 2 months around the delivery. Afterwards, sexual interest and activity tends to be reduced for several months as compared with the prepregnancy level, and sexual problems occur relatively often. But most remarkable is the interindividual variability concerning sexual responsiveness, orgasm, activity, and enjoyment. Descriptive research is focused on coital activity of (expectant) mothers. Data about fathers, noncoital activities, and sexual feelings are scarce. Data analysis is focused on three questions: (1) Does sexual activity in pregnancy harm the fetus? (if there are no risk factors: no); (2) Are physical and mental symptoms or data about the delivery and sexual variables correlated? (in some cases: yes); (3) Are sociodemographic data and sexual variables correlated? (mostly not). Research deficits (e.g., conceptual reductionism "sexuality=intercourse," neglect of the male partners, validity, reliability, neglect of the nonsexual partnership and of biographical influences) are critically discussed. Medical, counseling, and psychotherapeutic implications are derived.

Spatio-temporal dynamics of ocean conditions and forage taxa reveal regional structuring of seabird–prey relationships.

PubMed

Santora, Jarrod A; Schroeder, Isaac D; Field, John C; Wells, Brian K; Sydeman, William J

Studies of predator–prey demographic responses and the physical drivers of such relationships are rare, yet essential for predicting future changes in the structure and dynamics of marine ecosystems. Here, we hypothesize that predator–prey relationships vary spatially in association with underlying physical ocean conditions, leading to observable changes in demographic rates, such as reproduction. To test this hypothesis, we quantified spatio-temporal variability in hydrographic conditions, krill, and forage fish to model predator (seabird) demographic responses over 18 years (1990–2007). We used principal component analysis and spatial correlation maps to assess coherence among ocean conditions, krill, and forage fish, and generalized additive models to quantify interannual variability in seabird breeding success relative to prey abundance. The first principal component of four hydrographic measurements yielded an index that partitioned “warm/weak upwelling” and “cool/strong upwelling” years. Partitioning of krill and forage fish time series among shelf and oceanic regions yielded spatially explicit indicators of prey availability. Krill abundance within the oceanic region was remarkably consistent between years, whereas krill over the shelf showed marked interannual fluctuations in relation to ocean conditions. Anchovy abundance varied on the shelf, and was greater in years of strong stratification, weak upwelling and warmer temperatures. Spatio-temporal variability of juvenile forage fish co-varied strongly with each other and with krill, but was weakly correlated with hydrographic conditions. Demographic responses between seabirds and prey availability revealed spatially variable associations indicative of the dynamic nature of “predator–habitat” relationships. Quantification of spatially explicit demographic responses, and their variability through time, demonstrate the possibility of delineating specific critical areas where the implementation of protective measures could maintain functions and productivity of central place foraging predators.

A linear stepping endovascular intervention robot with variable stiffness and force sensing.

PubMed

He, Chengbin; Wang, Shuxin; Zuo, Siyang

2018-05-01

Robotic-assisted endovascular intervention surgery has attracted significant attention and interest in recent years. However, limited designs have focused on the variable stiffness mechanism of the catheter shaft. Flexible catheter needs to be partially switched to a rigid state that can hold its shape against external force to achieve a stable and effective insertion procedure. Furthermore, driving catheter in a similar way with manual procedures has the potential to make full use of the extensive experience from conventional catheter navigation. Besides driving method, force sensing is another significant factor for endovascular intervention. This paper presents a variable stiffness catheterization system that can provide stable and accurate endovascular intervention procedure with a linear stepping mechanism that has a similar operation mode to the conventional catheter navigation. A specially designed shape-memory polymer tube with water cooling structure is used to achieve variable stiffness of the catheter. Hence, four FBG sensors are attached to the catheter tip in order to monitor the tip contact force situation with temperature compensation. Experimental results show that the actuation unit is able to deliver linear and rotational motions. We have shown the feasibility of FBG force sensing to reduce the effect of temperature and detect the tip contact force. The designed catheter can change its stiffness partially, and the stiffness of the catheter can be remarkably increased in rigid state. Hence, in the rigid state, the catheter can hold its shape against a [Formula: see text] load. The prototype has also been validated with a vascular phantom, demonstrating the potential clinical value of the system. The proposed system provides important insights into the design of compact robotic-assisted catheter incorporating effective variable stiffness mechanism and real-time force sensing for intraoperative endovascular intervention.

Inter-individual variability in response to non-invasive brain stimulation paradigms.

PubMed

López-Alonso, Virginia; Cheeran, Binith; Río-Rodríguez, Dan; Fernández-Del-Olmo, Miguel

2014-01-01

Non-invasive Brain Stimulation (NIBS) paradigms are unique in their ability to safely modulate cortical plasticity for experimental or therapeutic applications. However, increasingly, there is concern regarding inter-individual variability in the efficacy and reliability of these paradigms. Inter-individual variability in response to NIBS paradigms would be better explained if a multimodal distribution was assumed. In three different sessions for each subject (n = 56), we studied the Paired Associative Stimulation (PAS25), Anodal transcranial DC stimulation (AtDCS) and intermittent theta burst stimulation (iTBS) protocols. We applied cluster analysis to detect distinct patterns of response between individuals. Furthermore, we tested whether baseline TMS measures (such as short intracortical inhibition (SICI), resting motor threshold (RMT)) or factors such as time of day could predict each individual's response pattern. All three paradigms show similar efficacy over the first hour post stimulation--there is no significant effect on excitatory or inhibitory circuits for the whole sample, and AtDCS fares no better than iTBS or PAS25. Cluster analysis reveals a bimodal response pattern--but only 39%, 45% and 43% of subjects responded as expected to PAS25, AtDCS, and iTBS respectively. Pre-stimulation SICI accounted for 10% of the variability in response to PAS25, but no other baseline measures were predictive of response. Finally, we report implications for sample size calculation and the remarkable effect of sample enrichment. The implications of the high rate of 'dose-failure' for experimental and therapeutic applications of NIBS lead us to conclude that addressing inter-individual variability is a key area of concern for the field. Copyright © 2014 Elsevier Inc. All rights reserved.

Efficient continuous-variable state tomography using Padua points

NASA Astrophysics Data System (ADS)

Landon-Cardinal, Olivier; Govia, Luke C. G.; Clerk, Aashish A.

Further development of quantum technologies calls for efficient characterization methods for quantum systems. While recent work has focused on discrete systems of qubits, much remains to be done for continuous-variable systems such as a microwave mode in a cavity. We introduce a novel technique to reconstruct the full Husimi Q or Wigner function from measurements done at the Padua points in phase space, the optimal sampling points for interpolation in 2D. Our technique not only reduces the number of experimental measurements, but remarkably, also allows for the direct estimation of any density matrix element in the Fock basis, including off-diagonal elements. OLC acknowledges financial support from NSERC.

M31N 2008-12a-The Remarkable Recurrent Nova in M31-Panchromatic Observations of the 2015 Eruption

NASA Technical Reports Server (NTRS)

Darnley, M. J.; Henze, M.; Bode, M. F.; Hachisu, I.; Hernanz, M.; Hornoch, K.; Hounsell, R.; Kato, M.; Ness, J.- U.; Osborne, J. P.;

Parametric Sensitivity Analysis for the Asian Summer Monsoon Precipitation Simulation in the Beijing Climate Center AGCM Version 2.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Ben; Zhang, Yaocun; Qian, Yun

In this study, we apply an efficient sampling approach and conduct a large number of simulations to explore the sensitivity of the simulated Asian summer monsoon (ASM) precipitation, including the climatological state and interannual variability, to eight parameters related to the cloud and precipitation processes in the Beijing Climate Center AGCM version 2.1 (BCC_AGCM2.1). Our results show that BCC_AGCM2.1 has large biases in simulating the ASM precipitation. The precipitation efficiency and evaporation coefficient for deep convection are the most sensitive parameters in simulating the ASM precipitation. With optimal parameter values, the simulated precipitation climatology could be remarkably improved, e.g. increasedmore » precipitation over the equator Indian Ocean, suppressed precipitation over the Philippine Sea, and more realistic Meiyu distribution over Eastern China. The ASM precipitation interannual variability is further analyzed, with a focus on the ENSO impacts. It shows the simulations with better ASM precipitation climatology can also produce more realistic precipitation anomalies during El Niño decaying summer. In the low-skill experiments for precipitation climatology, the ENSO-induced precipitation anomalies are most significant over continents (vs. over ocean in observation) in the South Asian monsoon region. More realistic results are derived from the higher-skill experiments with stronger anomalies over the Indian Ocean and weaker anomalies over India and the western Pacific, favoring more evident easterly anomalies forced by the tropical Indian Ocean warming and stronger Indian Ocean-western Pacific tele-connection as observed. Our model results reveal a strong connection between the simulated ASM precipitation climatological state and interannual variability in BCC_AGCM2.1 when key parameters are perturbed.« less

Clones of cells switch from reduction to enhancement of size variability in Arabidopsis sepals

PubMed Central

Tsugawa, Satoru; Hervieux, Nathan; Kierzkowski, Daniel; Routier-Kierzkowska, Anne-Lise; Sapala, Aleksandra; Hamant, Olivier; Smith, Richard S.; Boudaoud, Arezki

2017-01-01

Organs form with remarkably consistent sizes and shapes during development, whereas a high variability in growth is observed at the cell level. Given this contrast, it is unclear how such consistency in organ scale can emerge from cellular behavior. Here, we examine an intermediate scale, the growth of clones of cells in Arabidopsis sepals. Each clone consists of the progeny of a single progenitor cell. At early stages, we find that clones derived from a small progenitor cell grow faster than those derived from a large progenitor cell. This results in a reduction in clone size variability, a phenomenon we refer to as size uniformization. By contrast, at later stages of clone growth, clones change their growth pattern to enhance size variability, when clones derived from larger progenitor cells grow faster than those derived from smaller progenitor cells. Finally, we find that, at early stages, fast growing clones exhibit greater cell growth heterogeneity. Thus, cellular variability in growth might contribute to a decrease in the variability of clones throughout the sepal. PMID:29183944

Time-Variable Gravity from Satellite Laser-Ranging: The Low-Degree Components and Their Connections with Geophysical/Climatic Changes

NASA Technical Reports Server (NTRS)

Chao, Benjamin F.; Cox, Christopher M.

2004-01-01

Satellite laser-ranging (SLR) has been observing the tiny variations in Earth s global gravity for over 2 decades. The oblateness of the Earth's gravity field, J2, has been observed to undergo a secular decrease of J2 due mainly to the post-glacial rebound of the mantle. Sometime around 1998 this trend reversed quite suddenly. This reversal persisted until 2001, at which point the atmosphere-corrected time series appears to have reversed yet again towards normal. This anomaly signifies a large interannual change in global mass distribution. A number of possible causes have been considered, with oceanic mass redistribution as the leading candidate although other effects, such as glacial melting and core effects may be contributing. In fact, a strong correlation has been found between the J2 variability and the Pacific decadal oscillation. It is relatively more difficult to solve for corresponding signals in the shorter wavelength harmonics from the existing SLR-derived time variable gravity results, although it appears that geophysical fluid mass transport is being observed. For example, the recovered J3 time series shows remarkable agreement with NCEP-derived estimates of atmospheric gravity variations. Likewise, some of the non-zonal harmonic components have significant interannual signal that appears to be related to mass transport related to climatic effects such as El Nino Southern Oscillation. We will present recent updates on the J2 evolution, as well as a monthly time sequence of low-degree component map of the time-variable gravity complete through degree 4, and examine possible geophysical/climatic causes.

Simulation of Anomalous Regional Climate Events with a Variable Resolution Stretched Grid GCM

NASA Technical Reports Server (NTRS)

Fox-Rabinovitz, Michael S.

1999-01-01

The stretched-grid approach provides an efficient down-scaling and consistent interactions between global and regional scales due to using one variable-resolution model for integrations. It is a workable alternative to the widely used nested-grid approach introduced over a decade ago as a pioneering step in regional climate modeling. A variable-resolution General Circulation Model (GCM) employing a stretched grid, with enhanced resolution over the US as the area of interest, is used for simulating two anomalous regional climate events, the US summer drought of 1988 and flood of 1993. The special mode of integration using a stretched-grid GCM and data assimilation system is developed that allows for imitating the nested-grid framework. The mode is useful for inter-comparison purposes and for underlining the differences between these two approaches. The 1988 and 1993 integrations are performed for the two month period starting from mid May. Regional resolutions used in most of the experiments is 60 km. The major goal and the result of the study is obtaining the efficient down-scaling over the area of interest. The monthly mean prognostic regional fields for the stretched-grid integrations are remarkably close to those of the verifying analyses. Simulated precipitation patterns are successfully verified against gauge precipitation observations. The impact of finer 40 km regional resolution is investigated for the 1993 integration and an example of recovering subregional precipitation is presented. The obtained results show that the global variable-resolution stretched-grid approach is a viable candidate for regional and subregional climate studies and applications.

Atmospheric Parameter Climatologies from AIRS: Monitoring Short-, and Longer-Term Climate Variabilities and 'Trends'

NASA Technical Reports Server (NTRS)

Molnar, Gyula; Susskind, Joel

2008-01-01

The AIRS instrument is currently the best space-based tool to simultaneously monitor the vertical distribution of key climatically important atmospheric parameters as well as surface properties, and has provided high quality data for more than 5 years. AIRS analysis results produced at the GODDARD/DAAC, based on Versions 4 & 5 of the AIRS retrieval algorithm, are currently available for public use. Here, first we present an assessment of interrelationships of anomalies (proxies of climate variability based on 5 full years, since Sept. 2002) of various climate parameters at different spatial scales. We also present AIRS-retrievals-based global, regional and 1x1 degree grid-scale "trend"-analyses of important atmospheric parameters for this 5-year period. Note that here "trend" simply means the linear fit to the anomaly (relative the mean seasonal cycle) time series of various parameters at the above-mentioned spatial scales, and we present these to illustrate the usefulness of continuing AIRS-based climate observations. Preliminary validation efforts, in terms of intercomparisons of interannual variabilities with other available satellite data analysis results, will also be addressed. For example, we show that the outgoing longwave radiation (OLR) interannual spatial variabilities from the available state-of-the-art CERES measurements and from the AIRS computations are in remarkably good agreement. Version 6 of the AIRS retrieval scheme (currently under development) promises to further improve bias agreements for the absolute values by implementing a more accurate radiative transfer model for the OLR computations and by improving surface emissivity retrievals.

A numerical study on the seasonal variability of polychlorinated biphenyls from the atmosphere in the East China Sea.

PubMed

Ono, Jun; Takahashi, Daisuke; Guo, Xinyu; Takahashi, Shin; Takeoka, Hidetaka

2012-10-01

A three-dimensional/high-resolution transport model for persistent organic pollutants (POPs) has been developed for the East China Sea (ECS). The POPs model has four compartments (gaseous, dissolved, phytoplankton-bound, and detritus-bound phases) and includes processes for diffusive air-water exchange, phytoplankton uptake/depuration to POPs, decomposition of dissolved phase, vertical sinking of phytoplankton, detritus production by phytoplankton mortality, and vertical sinking and decomposition of detritus. The POPs model is coupled with an ocean circulation model that can reproduce the seasonal variation in physical variables to represent the advection and diffusion of POPs. We applied the POPs model to the polychlorinated biphenyl congener 153 (PCB 153) from the atmosphere and examined the behavior of PCB 153 in the ocean. The model showed a remarkable seasonal variability of PCB 153. Concentrations in the dissolved and particulate phases are high in winter (January-March) and low in summer (July-September). In coastal regions, where chlorophyll a concentration is high, horizontal and vertical distributions in the dissolved and particulate PCB 153 concentrations are strongly affected by phytoplankton uptake. The sensitivity experiments on the dynamics of PCB 153 suggested that a change of Henry's law constant associated with water temperature is the major factor controlling the seasonal variability of PCB 153. The model-based yearly mass balance of PCB 153 in the ECS indicated that most of the atmospheric input (35.5 kg year(-1)) is removed by the horizontal advection outside the ECS (19.0 kg year(-1)) and accumulates to the sea bottom by vertical sinking (15.7 kg year(-1)). For comparison with PCB 153, we also conducted simulations for PCB 52, 101, and 180. The seasonal variations are similar to that of PCB 153. The mass balance of PCB 52 that has short half-life time and less hydrophobic property shows the different results compared with PCB 101, 153, and 180. Copyright © 2012 Elsevier Ltd. All rights reserved.

Partitioning the impact of environment and spatial structure on alpha and beta components of taxonomic, functional, and phylogenetic diversity in European ants.

PubMed

Arnan, Xavier; Cerdá, Xim; Retana, Javier

2015-01-01

We analyze the relative contribution of environmental and spatial variables to the alpha and beta components of taxonomic (TD), phylogenetic (PD), and functional (FD) diversity in ant communities found along different climate and anthropogenic disturbance gradients across western and central Europe, in order to assess the mechanisms structuring ant biodiversity. To this aim we calculated alpha and beta TD, PD, and FD for 349 ant communities, which included a total of 155 ant species; we examined 10 functional traits and phylogenetic relatedness. Variation partitioning was used to examine how much variation in ant diversity was explained by environmental and spatial variables. Autocorrelation in diversity measures and each trait's phylogenetic signal were also analyzed. We found strong autocorrelation in diversity measures. Both environmental and spatial variables significantly contributed to variation in TD, PD, and FD at both alpha and beta scales; spatial structure had the larger influence. The different facets of diversity showed similar patterns along environmental gradients. Environment explained a much larger percentage of variation in FD than in TD or PD. All traits demonstrated strong phylogenetic signals. Our results indicate that environmental filtering and dispersal limitations structure all types of diversity in ant communities. Strong dispersal limitations appear to have led to clustering of TD, PD, and FD in western and central Europe, probably because different historical and evolutionary processes generated different pools of species. Remarkably, these three facets of diversity showed parallel patterns along environmental gradients. Trait-mediated species sorting and niche conservatism appear to structure ant diversity, as evidenced by the fact that more variation was explained for FD and that all traits had strong phylogenetic signals. Since environmental variables explained much more variation in FD than in PD, functional diversity should be a better indicator of community assembly processes than phylogenetic diversity.

Egg phenotype differentiation in sympatric cuckoo Cuculus canorus gentes.

PubMed

Antonov, Anton; Stokke, B G; Vikan, J R; Fossøy, F; Ranke, P S; Røskaft, E; Moksnes, A; Møller, A P; Shykoff, J A

2010-06-01

The brood parasitic common cuckoo Cuculus canorus consists of gentes, which typically parasitize only a single host species whose eggs they often mimic. Where multiple cuckoo gentes co-exist in sympatry, we may expect variable but generally poorer mimicry because of host switches or inter-gens gene flow via males if these also contribute to egg phenotypes. Here, we investigated egg trait differentiation and mimicry in three cuckoo gentes parasitizing great reed warblers Acrocephalus arundinaceus, marsh warblers Acrocephalus palustris and corn buntings Miliaria calandra breeding in close sympatry in partially overlapping habitat types. The three cuckoo gentes showed a remarkable degree of mimicry to their three host species in some but not all egg features, including egg size, a hitherto largely ignored feature of egg mimicry. Egg phenotype matching for both background and spot colours as well as for egg size has been maintained in close sympatry despite the possibility for gene flow.

Heterothermy in growing king penguins.

PubMed

Eichhorn, Götz; Groscolas, René; Le Glaunec, Gaële; Parisel, Camille; Arnold, Laurent; Medina, Patrice; Handrich, Yves

2011-08-16

A drop in body temperature allows significant energy savings in endotherms, but facultative heterothermy is usually restricted to small animals. Here we report that king penguin chicks (Aptenodytes patagonicus), which are able to fast for up to 5 months in winter, undergo marked seasonal heterothermy during this period of general food scarcity and slow-down of growth. They also experience short-term heterothermy below 20 °C in the lower abdomen during the intense (re)feeding period in spring, induced by cold meals and adverse weather. The heterothermic response involves reductions in peripheral temperature, reductions in thermal core volume and temporal abandonment of high core temperature. Among climate variables, air temperature and wind speed show the strongest effect on body temperature, but their effect size depends on physiological state. The observed heterothermy is remarkable for such a large bird (10 kg before fasting), which may account for its unrivalled fasting capacity among birds.

Spectral variations of LMC X-3 observed with Ginga

NASA Technical Reports Server (NTRS)

Ebisawa, Ken; Makino, Fumiyoshi; Mitsuda, Kazuhisa; Belloni, Tomaso; Cowley, Anne P.; Schmidtke, Paul C.; Treves, Aldo

1993-01-01

The prime black hole candidate LMC X-3 was observed over three years with the Ginga satellite, and a characteristic spectral variation was found accompanying the periodic intensity variation of about 198 (or possibly about 99) days (Cowley et al., 1991). The energy spectrum of LMC X-3 consists of the soft, thermal component and the hard, power-law component, which are respectively dominant below and above about 9 keV. The soft component, which carries most of the X-ray intensity, shows a clear correlation between the intensity and the hardness, while the hard component varies independently of the soft component. It was found that the spectral variation of the soft component is well described by an optically thick accretion disk model with a remarkably constant innermost radius and variable mass accretion rate. The constancy of the innermost radius suggests it is related to the mass of the central object.

High-rate measurement-device-independent quantum cryptography

NASA Astrophysics Data System (ADS)

Pirandola, Stefano; Ottaviani, Carlo; Spedalieri, Gaetana; Weedbrook, Christian; Braunstein, Samuel L.; Lloyd, Seth; Gehring, Tobias; Jacobsen, Christian S.; Andersen, Ulrik L.

2015-06-01

Quantum cryptography achieves a formidable task—the remote distribution of secret keys by exploiting the fundamental laws of physics. Quantum cryptography is now headed towards solving the practical problem of constructing scalable and secure quantum networks. A significant step in this direction has been the introduction of measurement-device independence, where the secret key between two parties is established by the measurement of an untrusted relay. Unfortunately, although qubit-implemented protocols can reach long distances, their key rates are typically very low, unsuitable for the demands of a metropolitan network. Here we show, theoretically and experimentally, that a solution can come from the use of continuous-variable systems. We design a coherent-state network protocol able to achieve remarkably high key rates at metropolitan distances, in fact three orders of magnitude higher than those currently achieved. Our protocol could be employed to build high-rate quantum networks where devices securely connect to nearby access points or proxy servers.

Dynamical predictive power of the generalized Gibbs ensemble revealed in a second quench.

PubMed

Zhang, J M; Cui, F C; Hu, Jiangping

2012-04-01

We show that a quenched and relaxed completely integrable system is hardly distinguishable from the corresponding generalized Gibbs ensemble in a dynamical sense. To be specific, the response of the quenched and relaxed system to a second quench can be accurately reproduced by using the generalized Gibbs ensemble as a substitute. Remarkably, as demonstrated with the transverse Ising model and the hard-core bosons in one dimension, not only the steady values but even the transient, relaxation dynamics of the physical variables can be accurately reproduced by using the generalized Gibbs ensemble as a pseudoinitial state. This result is an important complement to the previously established result that a quenched and relaxed system is hardly distinguishable from the generalized Gibbs ensemble in a static sense. The relevance of the generalized Gibbs ensemble in the nonequilibrium dynamics of completely integrable systems is then greatly strengthened.

[A case of an anti-Ma2 antibody-positive patient presenting with variable CNS symptoms mimicking multiple system atrophy with a partial response to immunotherapy].

PubMed

Shiraishi, Wataru; Iwanaga, Yasutaka; Yamamoto, Akifumi

2015-01-01

A 70-year-old man with a 5-month history of progressive bradykinesia of the bilateral lower extremities was admitted to our hospital. At the age of 64, he underwent proximal gastrectomy for gastric cancer. He also had a history of subacute combined degeneration of the spinal cord since the age of 67, which was successfully treated with vitamin B12 therapy. Four weeks before admission to our hospital, he admitted himself to his former hospital complaining of walking difficulty. Two weeks later, however, his symptoms progressed rapidly; he was immobilized for two weeks and did not respond to the vitamin therapy. On admission to our hospital, he showed moderate paralysis of the lower extremities, cog-wheel rigidity of the four extremities, and dystonic posture of his left hand. He also showed orthostatic hypotension and vesicorectal disorders. Blood examination and cerebrospinal fluid analysis revealed no remarkable abnormalities. Electroencephalography showed frontal dominant, high voltage, sharp waves. His brain and spinal MRI revealed no notable abnormalities. We suspected autoimmune disease and commenced one course of intravenous methylprednisolone therapy, resulting in improvement of the parkinsonism and orthostatic hypotension. Based on these results, we investigated possible neural antigens and detected anti-Ma2 antibody. In addition to limbic encephalitis, anti-Ma2 antibody-positive neural disorders are characterized by rapid eye movement sleep behavior disorders or parkinsonism. Here, we report an anti-Ma2 antibody positive patient presenting variable CNS symptoms mimicking multiple system atrophy, who responded to immunotherapy.

Widespread heterogeneous neuronal loss across the cerebral cortex in Huntington's disease.

PubMed

Nana, Alissa L; Kim, Eric H; Thu, Doris C V; Oorschot, Dorothy E; Tippett, Lynette J; Hogg, Virginia M; Synek, Beth J; Roxburgh, Richard; Waldvogel, Henry J; Faull, Richard L M

2014-01-01

Huntington's disease is an autosomal dominant neurodegenerative disease characterized by neuronal degeneration in the basal ganglia and cerebral cortex, and a variable symptom profile. Although progressive striatal degeneration is known to occur and is related to symptom profile, little is known about the cellular basis of symptom heterogeneity across the entire cerebral cortex. To investigate this, we have undertaken a double blind study using unbiased stereological cell counting techniques to determine the pattern of cell loss in six representative cortical regions from the frontal, parietal, temporal, and occipital lobes in the brains of 14 Huntington's disease cases and 15 controls. The results clearly demonstrate a widespread loss of total neurons and pyramidal cells across all cortical regions studied, except for the primary visual cortex. Importantly, the results show that cell loss is remarkably variable both within and between Huntington's disease cases. The results also show that neuronal loss in the primary sensory and secondary visual cortices relate to Huntington's disease motor symptom profiles, and neuronal loss across the associational cortices in the frontal, parietal and temporal lobes is related to both Huntington's disease motor and to mood symptom profiles. This finding considerably extends a previous study (Thu et al., Brain, 2010; 133:1094-1110) which showed that neuronal loss in the primary motor cortex was related specifically to the motor symptom profiles while neuronal loss in the anterior cingulate cortex was related specifically to mood symptom profiles. The extent of cortical cell loss in the current study was generally related to the striatal neuropathological grade, but not to CAG repeat length on the HTT gene. Overall our findings show that Huntington's disease is characterized by a heterogeneous pattern of neuronal cell loss across the entire cerebrum which varies with symptom profile.

Basic Research on Seismic and Infrasonic Monitoring of the European Arctic

DTIC Science & Technology

2008-09-01

characteristics as well as the inherent variability among these signals . We have used available recordings both from the Apatity infrasound array and from...experimentally attempt to generate an infrasonic event bulletin using only the estimated azimuths and detection times of infrasound phases recorded by... detection . Our studies have shown a remarkably efficient wave propagation from events near Novaya Zemlya across the Barents Sea. Significant signal

Marine mammal subspecies in the age of genetics: Introductory remarks from the Associate Editor and Editor-in-Chief of Marine Mammal Science

Treesearch

Michael K. Schwartz; Daryl J. Boness

2017-01-01

Almost every conservation genetics and evolutionary biology textbook has a section questioning: "What is a species or subspecies?" It has been one of the most discussed, nearly unanswerable questions in all of biology. At issue is how to logically divide a variable that is generally continuous, with some occasional discrete breaks. Answering this question is...

Communication—Electrolysis at High Efficiency with Remarkable Hydrogen Production Rates

DOE PAGES

Wood, Anthony; He, Hongpeng; Joia, Tahir; ...

2016-01-20

Solid Oxide Electrolysis (SOE) can be used to produce hydrogen with very high efficiencies at remarkable hydrogen production rates. Through microstructural and compositional modification, conventional low cost Solid Oxide Fuel Cell (SOFC) materials have been used to create a Solid Oxide Electrolysis Cell (SOEC) that can achieve remarkable current density at cell voltages allowing higher conversion efficiency than current commercial electrolysers. Current densities in excess of 6 A/cm2 have been achieved at 800°C with a cell voltage of < 1.67 V. This cell shows a more than 3-fold increase in hydrogen production rate at higher efficiency than established commercial electrolysers.

How right is left? Handedness modulates neural responses during morphosyntactic processing.

PubMed

Grey, Sarah; Tanner, Darren; van Hell, Janet G

2017-08-15

Most neurocognitive models of language processing generally assume population-wide homogeneity in the neural mechanisms used during language comprehension, yet individual differences are known to influence these neural mechanisms. In this study, we focus on handedness as an individual difference hypothesized to affect language comprehension. Left-handers and right-handers with a left-handed blood relative, or familial sinistrals, are hypothesized to process language differently than right-handers with no left-handed relatives (Hancock and Bever, 2013; Ullman, 2004). Yet, left-handers are often excluded from neurocognitive language research, and familial sinistrality in right-handers is often not taken into account. In the current study we used event-related potentials to test morphosyntactic processing in three groups that differed in their handedness profiles: left-handers (LH), right-handers with a left-handed blood relative (RH FS+), and right-handers with no reported left-handed blood relative (RH FS-; both right-handed groups were previously tested by Tanner and Van Hell, 2014). Results indicated that the RH FS- group showed only P600 responses during morphosyntactic processing whereas the LH and RH FS+ groups showed biphasic N400-P600 patterns. N400s in LH and RH FS+ groups are consistent with theories that associate left-handedness (self or familial) with increased reliance on lexical/semantic mechanisms during language processing. Inspection of individual-level results illustrated that variability in RH FS- individuals' morphosyntactic processing was remarkably low: most individuals were P600-dominant. In contrast, LH and RH FS+ individuals showed marked variability in brain responses, which was similar for both groups: half of individuals were N400-dominant and half were P600-dominant. Our findings have implications for neurocognitive models of language that have been largely formulated around data from only right-handers without accounting for familial sinistrality or including left-handers, and moreover highlight that there is systematic - and often ignored - variability in language processing outcomes in neurologically healthy populations. Copyright © 2017 Elsevier B.V. All rights reserved.

Unveiling Vela: time variability of interstellar lines in the direction of the Vela supernova remnant - II. Na D and Ca II

NASA Astrophysics Data System (ADS)

Kameswara Rao, N.; Lambert, David L.; Reddy, Arumalla B. S.; Gupta, Ranjan; Muneer, S.; Singh, Harinder P.

2017-05-01

In a survey conducted between 2011 and 2012 of interstellar Na I D line profiles in the direction of the Vela supernova remnant (SNR), a few lines of sight showed dramatic changes in low-velocity absorption components with respect to profiles from 1993 to 1994 reported by Cha & Sembach. Three stars - HD 63578, HD 68217 and HD 76161 - showed large decrease in strength over the 1993-2012 interval. HD 68217 and HD 76161 are associated with the Vela SNR whereas HD 63578 is associated with γ2 Velorum wind bubble. Here, we present high spectral resolution observations of Ca II K lines obtained with the Southern African Large Telescope towards these three stars along with simultaneous observations of Na I D lines. These new spectra confirm that the Na D interstellar absorption weakened drastically between 1993-1994 and 2011-2012 but show for the first time that the Ca II K line is unchanged between 1993-1994 and 2015. This remarkable contrast between the behaviour of Na D and Ca II K absorption lines is a puzzle concerning gas presumably affected by the outflow from the SNR and the wind from γ2 Velorum.

Microemulsion formulation design and evaluation for hydrophobic compound: Catechin topical application.

PubMed

Lin, Yu-Hsiang; Tsai, Ming-Jun; Fang, Yi-Ping; Fu, Yaw-Syan; Huang, Yaw-Bin; Wu, Pao-Chu

2018-01-01

The aim of the present study was to design a microemulsion for catechin topical application. A mixture experimental design with five independent variables (X 1 : oil, X 2 : surfactant, X 3 : catechin, X 4 : cosurfactant and X 5 : water) was developed, and the response surface methodology was used to study the effect of formulation components on physiochemical characteristics and penetration capacity of a catechin-loaded microemulsion, and to obtain an optimal microemulsion formulation. The results showed that the drug-loaded microemulsion formation and characteristics were related to many parameters of the components. The transdermal amounts in receiver cells and skin deposition amount remarkably increased about 4.1-111.6-fold and 0.6-7.6-fold respectively. The lag time was significantly shortened from 10h to 1.0-6.7h. The optimal formulation with 20% surfactant, 30% cosurfactant and 2.6% Catechin was subjected to stability and irritation tests. The results showed that the physicochemical characteristics and catechin level of the drug-loaded microemulsion did not show significant degradation after 3 months of storage at 25°C.The catechin-loaded microemulsion did not cause significant irritation compared to the water-treated group. Copyright © 2017 Elsevier B.V. All rights reserved.

Principal variance component analysis of crop composition data: a case study on herbicide-tolerant cotton.

PubMed

Harrison, Jay M; Howard, Delia; Malven, Marianne; Halls, Steven C; Culler, Angela H; Harrigan, George G; Wolfinger, Russell D

2013-07-03

Compositional studies on genetically modified (GM) and non-GM crops have consistently demonstrated that their respective levels of key nutrients and antinutrients are remarkably similar and that other factors such as germplasm and environment contribute more to compositional variability than transgenic breeding. We propose that graphical and statistical approaches that can provide meaningful evaluations of the relative impact of different factors to compositional variability may offer advantages over traditional frequentist testing. A case study on the novel application of principal variance component analysis (PVCA) in a compositional assessment of herbicide-tolerant GM cotton is presented. Results of the traditional analysis of variance approach confirmed the compositional equivalence of the GM and non-GM cotton. The multivariate approach of PVCA provided further information on the impact of location and germplasm on compositional variability relative to GM.

Development of students' interest in particle physics as effect of participating in a Masterclass

NASA Astrophysics Data System (ADS)

Gedigk, Kerstin; Pospiech, Gesche

2016-05-01

The International Hands On Particle Physics Masterclasses are enjoying increasing popularity worldwide every year. In Germany a national program was brought to live in 2010, which offers these appreciated events to whole classes or courses of high school students all over the year. These events were evaluated concerning the issues of students' interest in particle physics and their perception of the events. How several interest variables interact with each other and the perception of the events is answered by structural equation modelling (sect. 5.2). The results give information about the events' effects on the students' interest development in particle physics, show which event features are important ( e.g. the authenticity) and give information about practical approaches to improve the effects of the Masterclasses. Section 5.3 deals with a group of participants which have a high interest in particle physics 6-8 weeks after the participation. The number of these students is remarkable large, with 26% of all participants. The investigation of this group shows that the Masterclass participation has the same positive effect on both sexes and all levels of physics education.

Supervised Learning Based on Temporal Coding in Spiking Neural Networks.

PubMed

Mostafa, Hesham

2017-08-01

Gradient descent training techniques are remarkably successful in training analog-valued artificial neural networks (ANNs). Such training techniques, however, do not transfer easily to spiking networks due to the spike generation hard nonlinearity and the discrete nature of spike communication. We show that in a feedforward spiking network that uses a temporal coding scheme where information is encoded in spike times instead of spike rates, the network input-output relation is differentiable almost everywhere. Moreover, this relation is piecewise linear after a transformation of variables. Methods for training ANNs thus carry directly to the training of such spiking networks as we show when training on the permutation invariant MNIST task. In contrast to rate-based spiking networks that are often used to approximate the behavior of ANNs, the networks we present spike much more sparsely and their behavior cannot be directly approximated by conventional ANNs. Our results highlight a new approach for controlling the behavior of spiking networks with realistic temporal dynamics, opening up the potential for using these networks to process spike patterns with complex temporal information.

Remarkable convergent evolution in specialized parasitic Thecostraca (Crustacea)

PubMed Central

Pérez-Losada, Marcos; Høeg, Jens T; Crandall, Keith A

2009-01-01

Background The Thecostraca are arguably the most morphologically and biologically variable group within the Crustacea, including both suspension feeders (Cirripedia: Thoracica and Acrothoracica) and parasitic forms (Cirripedia: Rhizocephala, Ascothoracida and Facetotecta). Similarities between the metamorphosis found in the Facetotecta and Rhizocephala suggests a common evolutionary origin, but until now no comprehensive study has looked at the basic evolution of these thecostracan groups. Results To this end, we collected DNA sequences from three nuclear genes [18S rRNA (2,305), 28S rRNA (2,402), Histone H3 (328)] and 41 larval characters in seven facetotectans, five ascothoracidans, three acrothoracicans, 25 rhizocephalans and 39 thoracicans (ingroup) and 12 Malacostraca and 10 Copepoda (outgroup). Maximum parsimony, maximum likelihood and Bayesian analyses showed the Facetotecta, Ascothoracida and Cirripedia each as monophyletic. The better resolved and highly supported DNA maximum likelihood and morphological-DNA Bayesian analysis trees depicted the main phylogenetic relationships within the Thecostraca as (Facetotecta, (Ascothoracida, (Acrothoracica, (Rhizocephala, Thoracica)))). Conclusion Our analyses indicate a convergent evolution of the very similar and highly reduced slug-shaped stages found during metamorphosis of both the Rhizocephala and the Facetotecta. This provides a remarkable case of convergent evolution and implies that the advanced endoparasitic mode of life known from the Rhizocephala and strongly indicated for the Facetotecta had no common origin. Future analyses are needed to determine whether the most recent common ancestor of the Thecostraca was free-living or some primitive form of ectoparasite. PMID:19374762

Perceptions of racial confrontation: the role of color blindness and comment ambiguity.

PubMed

Zou, Linda X; Dickter, Cheryl L

2013-01-01

Because of its emphasis on diminishing race and avoiding racial discourse, color-blind racial ideology has been suggested to have negative consequences for modern day race relations. The current research examined the influence of color blindness and the ambiguity of a prejudiced remark on perceptions of a racial minority group member who confronts the remark. One hundred thirteen White participants responded to a vignette depicting a White character making a prejudiced comment of variable ambiguity, after which a Black target character confronted the comment. Results demonstrated that the target confronter was perceived more negatively and as responding less appropriately by participants high in color blindness, and that this effect was particularly pronounced when participants responded to the ambiguous comment. Implications for the ways in which color blindness, as an accepted norm that is endorsed across legal and educational settings, can facilitate Whites' complicity in racial inequality are discussed.

Quantum Machine Learning over Infinite Dimensions

DOE PAGES

Lau, Hoi-Kwan; Pooser, Raphael; Siopsis, George; ...

2017-02-21

Machine learning is a fascinating and exciting eld within computer science. Recently, this ex- citement has been transferred to the quantum information realm. Currently, all proposals for the quantum version of machine learning utilize the nite-dimensional substrate of discrete variables. Here we generalize quantum machine learning to the more complex, but still remarkably practi- cal, in nite-dimensional systems. We present the critical subroutines of quantum machine learning algorithms for an all-photonic continuous-variable quantum computer that achieve an exponential speedup compared to their equivalent classical counterparts. Finally, we also map out an experi- mental implementation which can be used as amore » blueprint for future photonic demonstrations.« less

On the long term evolution of white dwarfs in cataclysmic variables and their recurrence times

NASA Technical Reports Server (NTRS)

Sion, E. M.; Starrfield, S. G.

1985-01-01

The relevance of the long term quasi-static evolution of accreting white dwarfs to the outbursts of Z Andromeda-like symbiotics; the masses and accretion rates of classical nova white dwarfs; and the observed properties of white dwarfs detected optically and with IUE in low M dot cataclysmic variables is discussed. A surface luminosity versus time plot for a massive, hot white dwarf bears a remarkable similarity to the outburst behavior of the hot blue source in Z Andromeda. The long term quasi-static models of hot accreting white dwarfs provide convenient constraints on the theoretically permissible parameters to give a dynamical (nova-like) outburst of classic white dwarfs.

Quantum Machine Learning over Infinite Dimensions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lau, Hoi-Kwan; Pooser, Raphael; Siopsis, George

Machine learning is a fascinating and exciting eld within computer science. Recently, this ex- citement has been transferred to the quantum information realm. Currently, all proposals for the quantum version of machine learning utilize the nite-dimensional substrate of discrete variables. Here we generalize quantum machine learning to the more complex, but still remarkably practi- cal, in nite-dimensional systems. We present the critical subroutines of quantum machine learning algorithms for an all-photonic continuous-variable quantum computer that achieve an exponential speedup compared to their equivalent classical counterparts. Finally, we also map out an experi- mental implementation which can be used as amore » blueprint for future photonic demonstrations.« less

Colonizing the world in spite of reduced MHC variation

USGS Publications Warehouse

Gangoso, L.; Alcaide, M.; Grande, J.M.; Muñoz, J.; Talbot, Sandra L.; Sonsthagen, Sarah A.; Sage, Kevin; Figuerola, J.

2012-01-01

Reduced immune gene diversity is thought to negatively affect the capacity of organisms to adapt to pathogen challenges, which represent a major force in natural selection. Genes of the Major Histocompatibility Complex (MHC) are the most widely invoked adaptive loci in conservation biology, and have become the most popular genetic markers to investigate pathogen-host interactions in vertebrates. Although MHC genes are the most polymorphic genes described in the vertebrate genome, the extent to which MHC diversity determines the long-term persistence of populations is, unclear and often debated, as recent studies have documented the occurrence of natural populations thriving even after a depletion of MHC diversity caused by genetic drift. Here, we show that some phylogenetically related species belonging to the Falco genus (Aves: Falconidae) present a dramatically low MHC variability that has not precluded, nevertheless, the successful colonization of almost all existing regions and habitats worldwide. We found evidence for two remarkably different patterns of MHC variation within the genus. While kestrels show a high MHC variation according to the general theory, falcons exhibit an ancestrally low intra- and inter-specific MHC allelic diversity. We provide compelling evidence that this pattern is not caused by the degeneration of functional genes into pseudogenes, the inadvertent analyses of paralogous MHC genes, or the devastating action of genetic drift. Instead, our results strongly support the idea of an evolutionary transition driven and maintained by natural selection from primarily highly variable towards low polymorphic, but functional and expressed, MHC genes with species-specific pathogen-recognition capabilities.

A Quantitative Characterization and Classification of Martian Valley Networks: New Constraints on Mars' Early Climate and Its Variability in Space and Time

NASA Astrophysics Data System (ADS)

Grau Galofre, A.; Jellinek, M.

2014-12-01

Valley networks and outflow channels are among the most arresting features of Mars' surface. Remarkable similarities between the structure and complexity of individual Martian channels with certain fluvial systems on Earth supports a popular picture of a warm wet early Mars. A key assumption in this picture is that "typical" Martian examples adequately capture the average character of the majority of all valley networks. However, a full catalog of the distribution of geomorphologic variability of valley networks over Mars' surface geometry has never been established. Accordingly, we present the first planet-wide map in which we use statistical methods and theoretical arguments to classify Martian channels in terms of the mechanics governing their formation. Using new metrics for the size, shape and complexity of channel networks, which we ground truth against a large suite of terrestrial examples, we distinguish drainage patterns related to glacial, subglacial, fluvial and lava flows. Preliminary results separate lava flows from other flow features and show that these features can be divided into three different groups of increasing complexity. The characteristics of these groups suggest that they represent fluvial, subglacial and glacial features. We show also that the relative proportions of the different groups varies systematically, with higher density of river-like features located in low longitudes and increasing glacial-like features as we move east or west. Our results suggest that the early Martian climate and hydrologic cycle was richer and more diverse than originally thought.

Reconciling the temperature dependence of respiration across timescales and ecosystem types.

PubMed

Yvon-Durocher, Gabriel; Caffrey, Jane M; Cescatti, Alessandro; Dossena, Matteo; del Giorgio, Paul; Gasol, Josep M; Montoya, José M; Pumpanen, Jukka; Staehr, Peter A; Trimmer, Mark; Woodward, Guy; Allen, Andrew P

2012-07-26

Ecosystem respiration is the biotic conversion of organic carbon to carbon dioxide by all of the organisms in an ecosystem, including both consumers and primary producers. Respiration exhibits an exponential temperature dependence at the subcellular and individual levels, but at the ecosystem level respiration can be modified by many variables including community abundance and biomass, which vary substantially among ecosystems. Despite its importance for predicting the responses of the biosphere to climate change, it is as yet unknown whether the temperature dependence of ecosystem respiration varies systematically between aquatic and terrestrial environments. Here we use the largest database of respiratory measurements yet compiled to show that the sensitivity of ecosystem respiration to seasonal changes in temperature is remarkably similar for diverse environments encompassing lakes, rivers, estuaries, the open ocean and forested and non-forested terrestrial ecosystems, with an average activation energy similar to that of the respiratory complex (approximately 0.65 electronvolts (eV)). By contrast, annual ecosystem respiration shows a substantially greater temperature dependence across aquatic (approximately 0.65 eV) versus terrestrial ecosystems (approximately 0.32 eV) that span broad geographic gradients in temperature. Using a model derived from metabolic theory, these findings can be reconciled by similarities in the biochemical kinetics of metabolism at the subcellular level, and fundamental differences in the importance of other variables besides temperature—such as primary productivity and allochthonous carbon inputs—on the structure of aquatic and terrestrial biota at the community level.

Interictal cardiorespiratory variability in temporal lobe and absence epilepsy in childhood.

PubMed

Varon, Carolina; Montalto, Alessandro; Jansen, Katrien; Lagae, Lieven; Marinazzo, Daniele; Faes, Luca; Van Huffel, Sabine

2015-04-01

It is well known that epilepsy has a profound effect on the autonomic nervous system, especially on the autonomic control of heart rate and respiration. This effect has been widely studied during seizure activity, but less attention has been given to interictal (i.e. seizure-free) activity. The studies that have been done on this topic, showed that heart rate and respiration can be affected individually, even without the occurrence of seizures. In this work, the interactions between these two individual physiological variables are analysed during interictal activity in temporal lobe and absence epilepsy in childhood. These interactions are assessed by decomposing the predictive information about heart rate variability, into different components like the transfer entropy, cross-entropy, self- entropy and the conditional self entropy. Each one of these components quantifies different types of shared information. However, when using the cross-entropy and the conditional self entropy, it is possible to split the information carried by the heart rate, into two main components, one related to respiration and one related to different mechanisms, like sympathetic activation. This can be done after assuming a directional link going from respiration to heart rate. After analysing all the entropy components, it is shown that in subjects with absence epilepsy the information shared by respiration and heart rate is significantly lower than for normal subjects. And a more remarkable finding indicates that this type of epilepsy seems to have a long term effect on the cardiac and respiratory control mechanisms of the autonomic nervous system.

ROBUSTNESS OF A RYTHMIC CIRCUIT TO SHORT AND LONG-TERM TEMPERATURE CHANGES

PubMed Central

TANG, LAMONT S.; TAYLOR, ADAM L.; RINBERG, ANATOLY; MARDER, EVE

2012-01-01

Recent computational and experimental work has shown that similar network performance can result from variable sets of synaptic and intrinsic properties. Because temperature is a global perturbation that differentially influences every biological process within the nervous system, one might therefore expect that individual animals would respond differently to temperature. Nonetheless, the phase relationships of the pyloric rhythm of the stomatogastric ganglion (STG) of the crab, Cancer borealis, are remarkably invariant between 7 and 23 °C (Tang et al., 2010). Here, we report that when isolated STG preparations were exposed to more extreme temperature ranges, their networks became non-rhythmic, or “crashed”, in a reversible fashion. Animals were acclimated for at least 3 weeks at 7 °C, 11 °C, or 19 °C. When networks from the acclimated animals were perturbed by acute physiologically relevant temperature ramps (11–23 °C), the network frequency and phase relationships were independent of the acclimation group. At high acute temperatures (>23 °C), circuits from the cold-acclimated animals produced less-regular pyloric rhythms than those from warm-acclimated animals. At high acute temperatures, phase relationships between pyloric neurons were more variable from animal to animal than at moderate acute temperatures, suggesting that individual differences across animals in intrinsic circuit parameters are revealed at high temperatures. This shows that individual and variable neuronal circuits can behave similarly in normal conditions, but their behavior may diverge when confronted with extreme external perturbations. PMID:22815521

The proboscis extension reflex to evaluate learning and memory in honeybees ( Apis mellifera): some caveats

NASA Astrophysics Data System (ADS)

Frost, Elisabeth H.; Shutler, Dave; Hillier, Neil Kirk

2012-09-01

The proboscis extension reflex (PER) is widely used in a classical conditioning (Pavlovian) context to evaluate learning and memory of a variety of insect species. The literature is particularly prodigious for honeybees ( Apis mellifera) with more than a thousand publications. Imagination appears to be the only limit to the types of challenges to which researchers subject honeybees, including all the sensory modalities and a broad diversity of environmental treatments. Accordingly, some remarkable insights have been achieved using PER. However, there are several challenges to evaluating the PER literature that warrant a careful and thorough review. We assess here variation in methods that makes interpretation of studies, even those researching the same question, tenuous. We suggest that the numerous variables that might influence experimental outcomes from PER be thoroughly detailed by researchers. Moreover, the influence of individual variables on results needs to carefully evaluated, as well as among two or more variables. Our intent is to encourage investigation of the influence of numerous variables on PER results.

The Folding of a Family of Three-Helix Bundle Proteins: Spectrin R15 Has a Robust Folding Nucleus, Unlike Its Homologous Neighbours☆

PubMed Central

Kwa, Lee Gyan; Wensley, Beth G.; Alexander, Crispin G.; Browning, Stuart J.; Lichman, Benjamin R.; Clarke, Jane

2014-01-01

Three homologous spectrin domains have remarkably different folding characteristics. We have previously shown that the slow-folding R16 and R17 spectrin domains can be altered to resemble the fast folding R15, in terms of speed of folding (and unfolding), landscape roughness and folding mechanism, simply by substituting five residues in the core. Here we show that, by contrast, R15 cannot be engineered to resemble R16 and R17. It is possible to engineer a slow-folding version of R15, but our analysis shows that this protein neither has a rougher energy landscape nor does change its folding mechanism. Quite remarkably, R15 appears to be a rare example of a protein with a folding nucleus that does not change in position or in size when its folding nucleus is disrupted. Thus, while two members of this protein family are remarkably plastic, the third has apparently a restricted folding landscape. PMID:24373753

Influence of Subpixel Scale Cloud Top Structure on Reflectances from Overcast Stratiform Cloud Layers

NASA Technical Reports Server (NTRS)

Loeb, N. G.; Varnai, Tamas; Winker, David M.

1998-01-01

Recent observational studies have shown that satellite retrievals of cloud optical depth based on plane-parallel model theory suffer from systematic biases that depend on viewing geometry, even when observations are restricted to overcast marine stratus layers, arguably the closest to plane parallel in nature. At moderate to low sun elevations, the plane-parallel model significantly overestimates the reflectance dependence on view angle in the forward-scattering direction but shows a similar dependence in the backscattering direction. Theoretical simulations are performed that show that the likely cause for this discrepancy is because the plane-parallel model assumption does not account for subpixel, scale variations in cloud-top height (i.e., "cloud bumps"). Monte Carlo simulation, comparing ID model radiances to radiances from overcast cloud field with 1) cloud-top height variation, but constant cloud volume extinction; 2) flat tops but horizontal variations in cloud volume extinction; and 3) variations in both cloud top height and cloud extinction are performed over a approximately equal to 4 km x 4 km domain (roughly the size of an individual GAC AVHRR pixel). The comparisons show that when cloud-top height variations are included, departures from 1D theory are remarkably similar (qualitatively) to those obtained observationally. In contrast, when clouds are assumed flat and only cloud extinction is variable, reflectance differences are much smaller and do not show any view-angle dependence. When both cloud-top height and cloud extinction variations are included, however, large increases in cloud extinction variability can enhance reflectance difference. The reason 3D-1D reflectance differences are more sensitive to cloud-top height variations in the forward-scattering direction (at moderate to low, sun elevations) is because photons leaving the cloud field in that direction experience fewer scattering events (low-order scattering) and are restricted to the topmost portions of the cloud. While reflectance deviations from 1D theory are much larger for bumpy clouds than for flat clouds with variable cloud extinction, differences in cloud albedo are comparable for these two cases.

Correlation between asthma and climate in the European Community Respiratory Health Survey.

PubMed

Verlato, Giuseppe; Calabrese, Rolando; De Marco, Roberto

2002-01-01

The European Community Respiratory Health Survey, performed during 1991-1993, found a remarkable geographical variability in the prevalence of asthma and asthma-like symptoms in individuals aged 20-44 yr. The highest values occurred in the English-speaking centers. In the present investigation, the ecological relationship between climate and symptom prevalence was evaluated in the 48 centers of the European Community Respiratory Health Survey. Meteorological variables were derived from the Global Historical Climatology Network and were averaged over an 11-yr period (i.e., 1980-1990). Respiratory symptom prevalence was directly related to temperature in the coldest month and was related inversely to the temperature in the hottest month. Warm winters and cool summers are features of oceanic climate found in most English-speaking centers of the European Community Respiratory Health Survey (i.e., England, New Zealand, and Oregon). In conclusion, climate can account for significant geographic variability in respiratory symptom prevalence.

The monsoon system: Land-sea breeze or the ITCZ?

NASA Astrophysics Data System (ADS)

Gadgil, Sulochana

2018-02-01

For well over 300 years, the monsoon has been considered to be a gigantic land-sea breeze driven by the land-ocean contrast in surface temperature. In this paper, this hypothesis and its implications for the variability of the monsoon are discussed and it is shown that the observations of monsoon variability do not support this popular theory of the monsoon. An alternative hypothesis (whose origins can be traced to Blanford's (1886) remarkably perceptive analysis) in which the basic system responsible for the Indian summer monsoon is considered to be the Intertropical Convergence Zone (ITCZ) or the equatorial trough, is then examined and shown to be consistent with the observations. The implications of considering the monsoon as a manifestation of the seasonal migration of the ITCZ for the variability of the Indian summer monsoon and for identification of the monsoonal regions of the world are briefly discussed.

Continuous-variable quantum probes for structured environments

NASA Astrophysics Data System (ADS)

Bina, Matteo; Grasselli, Federico; Paris, Matteo G. A.

2018-01-01

We address parameter estimation for structured environments and suggest an effective estimation scheme based on continuous-variables quantum probes. In particular, we investigate the use of a single bosonic mode as a probe for Ohmic reservoirs, and obtain the ultimate quantum limits to the precise estimation of their cutoff frequency. We assume the probe prepared in a Gaussian state and determine the optimal working regime, i.e., the conditions for the maximization of the quantum Fisher information in terms of the initial preparation, the reservoir temperature, and the interaction time. Upon investigating the Fisher information of feasible measurements, we arrive at a remarkable simple result: homodyne detection of canonical variables allows one to achieve the ultimate quantum limit to precision under suitable, mild, conditions. Finally, upon exploiting a perturbative approach, we find the invariant sweet spots of the (tunable) characteristic frequency of the probe, able to drive the probe towards the optimal working regime.

Supernovae 2016bdu and 2005gl, and their link with SN 2009ip-like transients: another piece of the puzzle

NASA Astrophysics Data System (ADS)

Pastorello, A.; Kochanek, C. S.; Fraser, M.; Dong, Subo; Elias-Rosa, N.; Filippenko, A. V.; Benetti, S.; Cappellaro, E.; Tomasella, L.; Drake, A. J.; Harmanen, J.; Reynolds, T.; Shappee, B. J.; Smartt, S. J.; Chambers, K. C.; Huber, M. E.; Smith, K.; Stanek, K. Z.; Christensen, E. J.; Denneau, L.; Djorgovski, S. G.; Flewelling, H.; Gall, C.; Gal-Yam, A.; Geier, S.; Heinze, A.; Holoien, T. W.-S.; Isern, J.; Kangas, T.; Kankare, E.; Koff, R. A.; Llapasset, J.-M.; Lowe, T. B.; Lundqvist, P.; Magnier, E. A.; Mattila, S.; Morales-Garoffolo, A.; Mutel, R.; Nicolas, J.; Ochner, P.; Ofek, E. O.; Prosperi, E.; Rest, A.; Sano, Y.; Stalder, B.; Stritzinger, M. D.; Taddia, F.; Terreran, G.; Tonry, J. L.; Wainscoat, R. J.; Waters, C.; Weiland, H.; Willman, M.; Young, D. R.; Zheng, W.

2018-02-01

Supernova (SN) 2016bdu is an unusual transient resembling SN 2009ip. SN 2009ip-like events are characterized by a long-lasting phase of erratic variability which ends with two luminous outbursts a few weeks apart. The second outburst is significantly more luminous (about 3 mag) than the first. In the case of SN 2016bdu, the first outburst (Event A) reached an absolute magnitude M(r) ~ -15.3 mag, while the second one (Event B) occurred over one month later and reached M(r) ~ -18 mag. By inspecting archival data, a faint source at the position of SN 2016bdu is detectable several times in the past few years. We interpret these detections as signatures of a phase of erratic variability, similar to that experienced by SN 2009ip between 2008 and mid-2012, and resembling the currently observed variability of the luminous blue variable SN 2000ch in NGC 3432. Spectroscopic monitoring of SN 2016bdu during the second peak initially shows features typical of a SN IIn. One month after the Event B maximum, the spectra develop broad Balmer lines with P Cygni profiles and broad metal features. At these late phases, the spectra resemble those of a typical Type II SN. All members of this SN 2009ip-like group are remarkably similar to the Type IIn SN 2005gl. For this object, the claim of a terminal SN explosion is supported by the disappearance of the progenitor star. The similarity with SN 2005gl suggests that all members of this family may finally explode as genuine SNe, although the unequivocal detection of nucleosynthesised elements in their nebular spectra is still missing.

Updating Known Distribution Models for Forecasting Climate Change Impact on Endangered Species

PubMed Central

Muñoz, Antonio-Román; Márquez, Ana Luz; Real, Raimundo

2013-01-01

To plan endangered species conservation and to design adequate management programmes, it is necessary to predict their distributional response to climate change, especially under the current situation of rapid change. However, these predictions are customarily done by relating de novo the distribution of the species with climatic conditions with no regard of previously available knowledge about the factors affecting the species distribution. We propose to take advantage of known species distribution models, but proceeding to update them with the variables yielded by climatic models before projecting them to the future. To exemplify our proposal, the availability of suitable habitat across Spain for the endangered Bonelli's Eagle (Aquila fasciata) was modelled by updating a pre-existing model based on current climate and topography to a combination of different general circulation models and Special Report on Emissions Scenarios. Our results suggested that the main threat for this endangered species would not be climate change, since all forecasting models show that its distribution will be maintained and increased in mainland Spain for all the XXI century. We remark on the importance of linking conservation biology with distribution modelling by updating existing models, frequently available for endangered species, considering all the known factors conditioning the species' distribution, instead of building new models that are based on climate change variables only. PMID:23840330

Updating known distribution models for forecasting climate change impact on endangered species.

PubMed

Muñoz, Antonio-Román; Márquez, Ana Luz; Real, Raimundo

2013-01-01

To plan endangered species conservation and to design adequate management programmes, it is necessary to predict their distributional response to climate change, especially under the current situation of rapid change. However, these predictions are customarily done by relating de novo the distribution of the species with climatic conditions with no regard of previously available knowledge about the factors affecting the species distribution. We propose to take advantage of known species distribution models, but proceeding to update them with the variables yielded by climatic models before projecting them to the future. To exemplify our proposal, the availability of suitable habitat across Spain for the endangered Bonelli's Eagle (Aquila fasciata) was modelled by updating a pre-existing model based on current climate and topography to a combination of different general circulation models and Special Report on Emissions Scenarios. Our results suggested that the main threat for this endangered species would not be climate change, since all forecasting models show that its distribution will be maintained and increased in mainland Spain for all the XXI century. We remark on the importance of linking conservation biology with distribution modelling by updating existing models, frequently available for endangered species, considering all the known factors conditioning the species' distribution, instead of building new models that are based on climate change variables only.

The origin of fluids in the salt beds of the Delaware Basin, New Mexico and Texas

USGS Publications Warehouse

O'Neil, J.R.; Johnson, C.M.; White, L.D.; Roedder, E.

1986-01-01

Oxygen and hydrogen isotope analyses have been made of (1) brines from several wells in the salt deposits of the Delaware Basin, (2) inclusion fluids in halite crystals from the ERDA No. 9 site, and (3) local ground waters of meteoric origin. The isotopic compositions indicate that the brines are genetically related and that they probably originated from the evaporation of paleo-ocean waters. Although highly variable in solute contents, the brines have rather uniform isotopic compositions. The stable isotope compositions of brine from the ERDA No. 6 site (826.3 m depth) and fluid inclusions from the ERDA No. 9 site are variable but remarkably regular and show that (1) mixing with old or modern meteoric waters has occurred, the extent of mixing apparently decreasing with depth, and (2) water in the ERDA No. 6 brine may have originated from the dehydration of gypsum. Alternatively, the data may reflect simple evaporation of meteoric water on a previously dry marine flat. Stable isotope compositions of all the waters analyzed indicate that there has been fairly extensive mixing with ground water throughout the area, but that no significant circulation has occurred. The conclusions bear importantly on the suitability of these salt beds and others as repositories for nuclear waste. ?? 1986.

Multiple-Locus Variable-Number Tandem Repeat Analysis of Dutch Bordetella pertussis Strains Reveals Rapid Genetic Changes with Clonal Expansion during the Late 1990s

PubMed Central

Schouls, Leo M.; van der Heide, Han G. J.; Vauterin, Luc; Vauterin, Paul; Mooi, Frits R.

2004-01-01

Bordetella pertussis, the causative agent of whooping cough, has remained endemic in The Netherlands despite extensive nationwide vaccination since 1953. In the 1990s, several epidemic periods have resulted in many cases of pertussis. We have proposed that strain variation has played a major role in the upsurges of this disease in The Netherlands. Therefore, molecular characterization of strains is important in identifying the causes of pertussis epidemiology. For this reason, we have developed a multiple-locus variable-number tandem repeat analysis (MLVA) typing system for B. pertussis. By combining the MLVA profile with the allelic profile based on multiple-antigen sequence typing, we were able to further differentiate strains. The relationships between the various genotypes were visualized by constructing a minimum spanning tree. MLVA of Dutch strains of B. pertussis revealed that the genotypes of the strains isolated in the prevaccination period were diverse and clearly distinct from the strains isolated in the 1990s. Furthermore, there was a decrease in diversity in the strains from the late 1990s, with a remarkable clonal expansion that coincided with the epidemic periods. Using this genotyping, we have been able to show that B. pertussis is much more dynamic than expected. PMID:15292152

Exogenous glutathione improves high root-zone temperature tolerance by modulating photosynthesis, antioxidant and osmolytes systems in cucumber seedlings

PubMed Central

Ding, Xiaotao; Jiang, Yuping; He, Lizhong; Zhou, Qiang; Yu, Jizhu; Hui, Dafeng; Huang, Danfeng

2016-01-01

To investigate the physiological responses of plants to high root-zone temperature (HT, 35 °C) stress mitigated by exogenous glutathione (GSH), cucumber (Cucumis sativus L.) seedlings were exposed to HT with or without GSH treatment for 4 days and following with 4 days of recovery. Plant physiological variables, growth, and gene expression related to antioxidant enzymes and Calvin cycle were quantified. The results showed that HT significantly decreased GSH content, the ratio of reduced to oxidized glutathione (GSH/GSSG), chlorophyll content, photosynthesis and related gene expression, shoot height, stem diameter, as well as dry weight. The exogenous GSH treatment clearly lessened the HT stress by increasing the above variables. Meanwhile, HT significantly increased soluble protein content, proline and malondialdehyde (MDA) content as well as O2•− production rate, the gene expression and activities of antioxidant enzymes. The GSH treatment remarkably improved soluble protein content, proline content, antioxidant enzymes activities, and antioxidant enzymes related gene expression, and reduced the MDA content and O2•− production rate compared to no GSH treatment in the HT condition. Our results suggest that exogenous GSH enhances cucumber seedling tolerance of HT stress by modulating the photosynthesis, antioxidant and osmolytes systems to improve physiological adaptation. PMID:27752105

Non-targeted 1H NMR fingerprinting and multivariate statistical analyses for the characterisation of the geographical origin of Italian sweet cherries.

PubMed

Longobardi, F; Ventrella, A; Bianco, A; Catucci, L; Cafagna, I; Gallo, V; Mastrorilli, P; Agostiano, A

2013-12-01

In this study, non-targeted (1)H NMR fingerprinting was used in combination with multivariate statistical techniques for the classification of Italian sweet cherries based on their different geographical origins (Emilia Romagna and Puglia). As classification techniques, Soft Independent Modelling of Class Analogy (SIMCA), Partial Least Squares Discriminant Analysis (PLS-DA), and Linear Discriminant Analysis (LDA) were carried out and the results were compared. For LDA, before performing a refined selection of the number/combination of variables, two different strategies for a preliminary reduction of the variable number were tested. The best average recognition and CV prediction abilities (both 100.0%) were obtained for all the LDA models, although PLS-DA also showed remarkable performances (94.6%). All the statistical models were validated by observing the prediction abilities with respect to an external set of cherry samples. The best result (94.9%) was obtained with LDA by performing a best subset selection procedure on a set of 30 principal components previously selected by a stepwise decorrelation. The metabolites that mostly contributed to the classification performances of such LDA model, were found to be malate, glucose, fructose, glutamine and succinate. Copyright © 2013 Elsevier Ltd. All rights reserved.

Individual Movement Variability Magnitudes Are Explained by Cortical Neural Variability.

PubMed

Haar, Shlomi; Donchin, Opher; Dinstein, Ilan

2017-09-13

Humans exhibit considerable motor variability even across trivial reaching movements. This variability can be separated into specific kinematic components such as extent and direction that are thought to be governed by distinct neural processes. Here, we report that individual subjects (males and females) exhibit different magnitudes of kinematic variability, which are consistent (within individual) across movements to different targets and regardless of which arm (right or left) was used to perform the movements. Simultaneous fMRI recordings revealed that the same subjects also exhibited different magnitudes of fMRI variability across movements in a variety of motor system areas. These fMRI variability magnitudes were also consistent across movements to different targets when performed with either arm. Cortical fMRI variability in the posterior-parietal cortex of individual subjects explained their movement-extent variability. This relationship was apparent only in posterior-parietal cortex and not in other motor system areas, thereby suggesting that individuals with more variable movement preparation exhibit larger kinematic variability. We therefore propose that neural and kinematic variability are reliable and interrelated individual characteristics that may predispose individual subjects to exhibit distinct motor capabilities. SIGNIFICANCE STATEMENT Neural activity and movement kinematics are remarkably variable. Although intertrial variability is rarely studied, here, we demonstrate that individual human subjects exhibit distinct magnitudes of neural and kinematic variability that are reproducible across movements to different targets and when performing these movements with either arm. Furthermore, when examining the relationship between cortical variability and movement variability, we find that cortical fMRI variability in parietal cortex of individual subjects explained their movement extent variability. This enabled us to explain why some subjects performed more variable movements than others based on their cortical variability magnitudes. Copyright © 2017 the authors 0270-6474/17/379076-10$15.00/0.

Did the reporting of prognostic studies of tumour markers improve since the introduction of REMARK guideline? A comparison of reporting in published articles

PubMed Central

Mallett, Susan; Altman, Douglas G.; Sauerbrei, Willi

2017-01-01

Although biomarkers are perceived as highly relevant for future clinical practice, few biomarkers reach clinical utility for several reasons. Among them, poor reporting of studies is one of the major problems. To aid improvement, reporting guidelines like REMARK for tumour marker prognostic (TMP) studies were introduced several years ago. The aims of this project were to assess whether reporting quality of TMP-studies improved in comparison to a previously conducted study assessing reporting quality of TMP-studies (PRE-study) and to assess whether articles citing REMARK (citing group) are better reported, in comparison to articles not citing REMARK (not-citing group). For the POST-study, recent articles citing and not citing REMARK (53 each) were identified in selected journals through systematic literature search and evaluated in same way as in the PRE-study. Ten of the 20 items of the REMARK checklist were evaluated and used to define an overall score of reporting quality. The observed overall scores were 53.4% (range: 10%-90%) for the PRE-study, 57.7% (range: 20%-100%) for the not-citing group and 58.1% (range: 30%-100%) for the citing group of the POST-study. While there is no difference between the two groups of the POST-study, the POST-study shows a slight but not relevant improvement in reporting relative to the PRE-study. Not all the articles of the citing group, cited REMARK appropriately. Irrespective of whether REMARK was cited, the overall score was slightly higher for articles published in journals requesting adherence to REMARK than for those published in journals not requesting it: 59.9% versus 51.9%, respectively. Several years after the introduction of REMARK, many key items of TMP-studies are still very poorly reported. A combined effort is needed from authors, editors, reviewers and methodologists to improve the current situation. Good reporting is not just nice to have but is essential for any research to be useful. PMID:28614415

Of Fighting Flies, Mice, and Men: Are Some of the Molecular and Neuronal Mechanisms of Aggression Universal in the Animal Kingdom?

PubMed

Thomas, Amanda L; Davis, Shaun M; Dierick, Herman A

2015-08-01

Aggressive behavior is widespread in the animal kingdom, but the degree of molecular conservation between distantly related species is still unclear. Recent reports suggest that at least some of the molecular mechanisms underlying this complex behavior in flies show remarkable similarities with such mechanisms in mice and even humans. Surprisingly, some aspects of neuronal control of aggression also show remarkable similarity between these distantly related species. We will review these recent findings, address the evolutionary implications, and discuss the potential impact for our understanding of human diseases characterized by excessive aggression.

Of Fighting Flies, Mice, and Men: Are Some of the Molecular and Neuronal Mechanisms of Aggression Universal in the Animal Kingdom?

PubMed Central

Dierick, Herman A.

2015-01-01

Aggressive behavior is widespread in the animal kingdom, but the degree of molecular conservation between distantly related species is still unclear. Recent reports suggest that at least some of the molecular mechanisms underlying this complex behavior in flies show remarkable similarities with such mechanisms in mice and even humans. Surprisingly, some aspects of neuronal control of aggression also show remarkable similarity between these distantly related species. We will review these recent findings, address the evolutionary implications, and discuss the potential impact for our understanding of human diseases characterized by excessive aggression. PMID:26312756

[The relation of the patient's condition and outcome of drug maintainance therapy in schizophrenia (analysis of the curative effect in 324 cases)].

PubMed

Zhang, Z

1989-12-01

Cf, the methodology and diagnostic standard of 12 collaborative units about "Epidemiological investigation" of 1982, we traced to investigate the relation between the patients' condition outcome and drug maintain therapy of 324 cases with schizophrenia in community. The investigative result showed the cure rate of insisting on taking medicine group was 25.21%, the effective rate was 97.48%, the cure rate of irregular taking medicine groups was 6.63%, the effective rate was 68.37%, there was remarkable difference between the cure rate and the effective rate in two groups. Otherwise we also compared the patients, condition of insisting on taking drug groups with during investigation. We found there was no remarkable change that showed insisting a drug maintain therapy out the hospital to the curative effect of the disease to possess on important meaning. The pattern also compared the curative effect of a time onset of disease group and many times. There was no remarkable difference about the statistical analysis of the curative effect among each group. It showed me never lose confidence to the patients. We should treat actively them.

Contrasting patterns of coral bleaching susceptibility in 2010 suggest an adaptive response to thermal stress.

PubMed

Guest, James R; Baird, Andrew H; Maynard, Jeffrey A; Muttaqin, Efin; Edwards, Alasdair J; Campbell, Stuart J; Yewdall, Katie; Affendi, Yang Amri; Chou, Loke Ming

2012-01-01

Coral bleaching events vary in severity, however, to date, the hierarchy of susceptibility to bleaching among coral taxa has been consistent over a broad geographic range and among bleaching episodes. Here we examine the extent of spatial and temporal variation in thermal tolerance among scleractinian coral taxa and between locations during the 2010 thermally induced, large-scale bleaching event in South East Asia. Surveys to estimate the bleaching and mortality indices of coral genera were carried out at three locations with contrasting thermal and bleaching histories. Despite the magnitude of thermal stress being similar among locations in 2010, there was a remarkable contrast in the patterns of bleaching susceptibility. Comparisons of bleaching susceptibility within coral taxa and among locations revealed no significant differences between locations with similar thermal histories, but significant differences between locations with contrasting thermal histories (Friedman = 34.97; p<0.001). Bleaching was much less severe at locations that bleached during 1998, that had greater historical temperature variability and lower rates of warming. Remarkably, Acropora and Pocillopora, taxa that are typically highly susceptible, although among the most susceptible in Pulau Weh (Sumatra, Indonesia) where respectively, 94% and 87% of colonies died, were among the least susceptible in Singapore, where only 5% and 12% of colonies died. The pattern of susceptibility among coral genera documented here is unprecedented. A parsimonious explanation for these results is that coral populations that bleached during the last major warming event in 1998 have adapted and/or acclimatised to thermal stress. These data also lend support to the hypothesis that corals in regions subject to more variable temperature regimes are more resistant to thermal stress than those in less variable environments.

The Broadband Spectral Variability of Holmberg IX X-1

NASA Astrophysics Data System (ADS)

Walton, D. J.; Fürst, F.; Harrison, F. A.; Middleton, M. J.; Fabian, A. C.; Bachetti, M.; Barret, D.; Miller, J. M.; Ptak, A.; Rana, V.; Stern, D.; Tao, L.

2017-04-01

We present results from four new broadband X-ray observations of the extreme ultraluminous X-ray source Holmberg IX X-1 ({L}{{X}}> {10}40 erg s-1), performed by Suzaku and NuSTAR in coordination. Combined with the archival data, we now have broadband observations of this remarkable source from six separate epochs. Two of these new observations probe lower fluxes than seen previously, allowing us to extend our knowledge of the broadband spectral variability exhibited. The spectra are well fit by two thermal blackbody components that dominate the emission below 10 keV, as well as a steep ({{Γ }}˜ 3.5) power-law tail that dominates above ˜15 keV. Remarkably, while the 0.3-10.0 keV flux varies by a factor of ˜3 between all these epochs, the 15-40 keV flux varies by only ˜20%. Although the spectral variability is strongest in the ˜1-10 keV band, both of the thermal components are required to vary when all epochs are considered. We also revisit the search for iron absorption features by leveraging the high-energy NuSTAR data to improve our sensitivity to extreme velocity outflows in light of the ultra-fast outflow recently detected in NGC 1313 X-1. Iron absorption from a similar outflow along our line of sight can be ruled out in this case. We discuss these results in the context of super-Eddington accretion models that invoke a funnel-like geometry for the inner flow, and propose a scenario in which we have an almost face-on view of a funnel that expands to larger radii with increasing flux, resulting in an increasing degree of geometrical collimation for the emission from intermediate-temperature regions.

Contrasting Patterns of Coral Bleaching Susceptibility in 2010 Suggest an Adaptive Response to Thermal Stress

PubMed Central

Guest, James R.; Baird, Andrew H.; Maynard, Jeffrey A.; Muttaqin, Efin; Edwards, Alasdair J.; Campbell, Stuart J.; Yewdall, Katie; Affendi, Yang Amri; Chou, Loke Ming

2012-01-01

Background Coral bleaching events vary in severity, however, to date, the hierarchy of susceptibility to bleaching among coral taxa has been consistent over a broad geographic range and among bleaching episodes. Here we examine the extent of spatial and temporal variation in thermal tolerance among scleractinian coral taxa and between locations during the 2010 thermally induced, large-scale bleaching event in South East Asia. Methodology/Principal Findings Surveys to estimate the bleaching and mortality indices of coral genera were carried out at three locations with contrasting thermal and bleaching histories. Despite the magnitude of thermal stress being similar among locations in 2010, there was a remarkable contrast in the patterns of bleaching susceptibility. Comparisons of bleaching susceptibility within coral taxa and among locations revealed no significant differences between locations with similar thermal histories, but significant differences between locations with contrasting thermal histories (Friedman = 34.97; p<0.001). Bleaching was much less severe at locations that bleached during 1998, that had greater historical temperature variability and lower rates of warming. Remarkably, Acropora and Pocillopora, taxa that are typically highly susceptible, although among the most susceptible in Pulau Weh (Sumatra, Indonesia) where respectively, 94% and 87% of colonies died, were among the least susceptible in Singapore, where only 5% and 12% of colonies died. Conclusions/Significance The pattern of susceptibility among coral genera documented here is unprecedented. A parsimonious explanation for these results is that coral populations that bleached during the last major warming event in 1998 have adapted and/or acclimatised to thermal stress. These data also lend support to the hypothesis that corals in regions subject to more variable temperature regimes are more resistant to thermal stress than those in less variable environments. PMID:22428027

The Broadband Spectral Variability of Holmberg IX X-1

NASA Technical Reports Server (NTRS)

Walton, D.J.; Furst, F.; Harrison, F.A.; Middleton, M.J.; Fabian, A. C.; Bachetti, M.; Barret, D.; Miller, J. M.; Ptak, A.; Rana, V.;

CYP3A variation and the evolution of salt-sensitivity variants.

PubMed

Thompson, E E; Kuttab-Boulos, H; Witonsky, D; Yang, L; Roe, B A; Di Rienzo, A

2004-12-01

Members of the cytochrome P450 3A subfamily catalyze the metabolism of endogenous substrates, environmental carcinogens, and clinically important exogenous compounds, such as prescription drugs and therapeutic agents. In particular, the CYP3A4 and CYP3A5 genes play an especially important role in pharmacogenetics, since they metabolize >50% of the drugs on the market. However, known genetic variants at these two loci are not sufficient to account for the observed phenotypic variability in drug response. We used a comparative genomics approach to identify conserved coding and noncoding regions at these genes and resequenced them in three ethnically diverse human populations. We show that remarkable interpopulation differences exist with regard to frequency spectrum and haplotype structure. The non-African samples are characterized by a marked excess of rare variants and the presence of a homogeneous group of long-range haplotypes at high frequency. The CYP3A5*1/*3 polymorphism, which is likely to influence salt and water retention and risk for salt-sensitive hypertension, was genotyped in >1,000 individuals from 52 worldwide population samples. The results reveal an unusual geographic pattern whereby the CYP3A5*3 frequency shows extreme variation across human populations and is significantly correlated with distance from the equator. Furthermore, we show that an unlinked variant, AGT M235T, previously implicated in hypertension and pre-eclampsia, exhibits a similar geographic distribution and is significantly correlated in frequency with CYP3A5*1/*3. Taken together, these results suggest that variants that influence salt homeostasis were the targets of a shared selective pressure that resulted from an environmental variable correlated with latitude.

CYP3A Variation and the Evolution of Salt-Sensitivity Variants

PubMed Central

Thompson, E. E.; Kuttab-Boulos, H.; Witonsky, D.; Yang, L.; Roe, B. A.; Di Rienzo, A.

2004-01-01

Members of the cytochrome P450 3A subfamily catalyze the metabolism of endogenous substrates, environmental carcinogens, and clinically important exogenous compounds, such as prescription drugs and therapeutic agents. In particular, the CYP3A4 and CYP3A5 genes play an especially important role in pharmacogenetics, since they metabolize >50% of the drugs on the market. However, known genetic variants at these two loci are not sufficient to account for the observed phenotypic variability in drug response. We used a comparative genomics approach to identify conserved coding and noncoding regions at these genes and resequenced them in three ethnically diverse human populations. We show that remarkable interpopulation differences exist with regard to frequency spectrum and haplotype structure. The non-African samples are characterized by a marked excess of rare variants and the presence of a homogeneous group of long-range haplotypes at high frequency. The CYP3A5*1/*3 polymorphism, which is likely to influence salt and water retention and risk for salt-sensitive hypertension, was genotyped in >1,000 individuals from 52 worldwide population samples. The results reveal an unusual geographic pattern whereby the CYP3A5*3 frequency shows extreme variation across human populations and is significantly correlated with distance from the equator. Furthermore, we show that an unlinked variant, AGT M235T, previously implicated in hypertension and pre-eclampsia, exhibits a similar geographic distribution and is significantly correlated in frequency with CYP3A5*1/*3. Taken together, these results suggest that variants that influence salt homeostasis were the targets of a shared selective pressure that resulted from an environmental variable correlated with latitude. PMID:15492926

The Effects of Day-to-Day Variability of Physiological Data on Operator Functional State Classification

DTIC Science & Technology

2013-03-01

fMRI data (e.g. Kamitami & Tong, 2005). This approach has been remarkably successful in classifying mental workload in complex tasks (Berka, et al...1991). These previous studies relied upon spectral comparison rather than classification. In previous research examining the stability of fMRI ...chose to focus on electrophysiology, as the collection conditions may be more carefully controlled across days than fMRI and it is more amenable to

On botulinum neurotoxin variability.

PubMed

Montecucco, Cesare; Rasotto, Maria Berica

2015-01-06

The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this remarkable phenomenon, we suggest that researchers should (i) abandon an anthropocentric view of these neurotoxins as human botulism-causing agents or as human therapeutics, (ii) begin to investigate in depth the role of botulinum neurotoxins in animal botulism in the wilderness, and (iii) devote large efforts to next-generation sequencing of soil samples to identify novel botulinum neurotoxins. In order to compare the fitness of the different toxins, we suggest that assays of all the steps from toxin production to animal death should be performed. Copyright © 2015 Montecucco and Rasotto.

Grasping the nettle: A bacterial invasin that targets immunoglobulin variable domains.

PubMed

Barlow, Paul

2018-06-01

In a new paper, the protein InvD from Yersinia pseudotuberculosis , a zoonotic pathogen, is shown to assist late-stage invasion of intestinal epithelia. Remarkably, InvD acts by binding the Fab region of IgG or IgA. It straddles adjacent light-chain and heavy-chain variable domains, but its binding is different from that of antigens in that complementarity-determining regions do not participate. Structure determination revealed that its Fab-interacting domain adopts an immunoglobulin-like fold, fused to the preceding immunoglobulin-like domain and carried on a long stalk anchored to the bacterial outer membrane. Possible roles of this unusual host-pathogen interaction include avoidance of clearance from the intestine by secretory IgA. © 2018 Barlow.

Spectral Variability of the UXOR Star RR Tau Over 2.5 Magnitudes in V

NASA Astrophysics Data System (ADS)

Rodgers, B.; Wooden, D. H.; Grinin, V. P.; Shakhovskoy, D.

2000-12-01

We present moderate resolution optical spectra of the highly variable Herbig Ae star RR Tau over 12 epochs spanning 2.5 magnitudes in V. The data cover most of the optical spectrum from the CaII K line in the blue to the CaII infrared triplet in the far red. Using contemporaneous photometric measurements from two sources, we have reliable estimates of the visual magnitude of the system at each spectral epoch. We find some spectral activity to be closely correlated with photometric variability, while other features are remarkably stable. Significant variability is common in the cores of Hα and Hβ , but is not well correlated with photometric variability. On the other hand, the wings (Δ v>400km/s) of the Balmer lines are quite stable, showing no change in spectral type when compared to Kurucz line profiles. This, along with the constant equivalent width seen in several weak metal lines, suggest that the physical conditions of the underlying continuum source are not changing significantly, despite a factor of ten change in brightness. In contrast, strong low-ionization permitted lines, such as FeII, CaII and NaI, are seen in deep absorption when the star is bright (V <= 12), but disappear during photometric minima to reveal weak emission lines. These absorption lines are not being filled in by the emission but rather are physically disappearing from the system. This could occur, for example, if an obscuring screen moved between the continuum source and the absorbing gas. The [OI]6300 line, a common wind diagnostic, is seen in emission at all epochs, with flux which is roughly constant except increasing slightly when the system is faint. We discuss these data in the context of different scenarios for the photometric variability and find them to be more consistent with the obscuration hypothesis, than changing accretion luminosity. This work is part of the dissertation research of B. Rodgers, which has been funded in large part by a NASA Graduate Student Research Program (GSRP) grant, for which D.H. Wooden is Rodgers' advisor. We gratefully acknowledge the use of the database of the Amateur Astronomers Variable Star Organization (AAVSO).

Effect of baroreceptor denervation on the autonomic control of arterial pressure in conscious mice.

PubMed

Rodrigues, Fernanda Luciano; de Oliveira, Mauro; Salgado, Helio Cesar; Fazan, Rubens

2011-09-01

This study evaluated the role of arterial baroreceptors in arterial pressure (AP) and pulse interval (PI) regulation in conscious C57BL mice. Male animals, implanted with catheters in a femoral artery and a jugular vein, were submitted to sino-aortic (SAD), aortic (Ao-X) or carotid sinus denervation (Ca-X), 5 days prior to the experiments. After basal recording of AP, the lack of reflex bradycardia elicited by administration of phenylephrine was used to confirm the efficacy of SAD, and cardiac autonomic blockade with methylatropine and propranolol was performed. The AP and PI variability were calculated in the time and frequency domains (spectral analysis/fast Fourier transform) with the spectra quantified in low- (LF; 0.25-1 Hz) and high-frequency bands (HF; 1-5 Hz). Basal AP and AP variability were higher after SAD, Ao-X or Ca-X than in intact mice. Pulse interval was similar among the groups, whereas PI variability was lower after SAD. Atropine elicited a slight tachycardia in control mice but did not change PI after total or partial denervation. The bradycardia caused by propranolol was higher after SAD, Ao-X or Ca-X compared with intact mice. The increase in the variability of AP was accompanied by a marked increase in the LF and HF power of the AP spectra after baroreceptor denervation. The LF and HF power of the PI were reduced by SAD and by Ao-X or Ca-X. Therefore, both sino-aortic and partial baroreceptor denervation in mice elicits hypertension and a remarkable increase in AP variability and cardiac sympathetic tonus. Spectral analysis showed an important contribution of the baroreflex in the power of LF oscillations of the PI spectra. Both sets of baroreceptors seem to be equally important in the autonomic regulation of the cardiovascular system in mice.

Remarkable variation in the informativeness of RFLP markers linked to hemophilia B locus in Indian population groups: implication in the strategy for carrier detection.

PubMed

Mukherjee, S; Saha, A; Kumar P, Senthil; Chandak, G R; Majumder, P P; Ray, K

2006-01-01

Hemophilia B, an X-linked recessive bleeding disorder, is caused by heterogeneous mutations in the factor IX (F9) gene. Hence, carriers of the disease are usually detected by F9 gene linked RFLP analysis. We aimed to test a set of RFLP markers (DdeI, XmnI, MnlI, TaqI & HhaI), used worldwide for carrier detection, to estimate its heterozygosity in different population groups of India, and identify additional single nucleotide polymorphisms (SNPs) if necessary. A total of 8 population groups encompassing different regions of India, consisting of 107 unrelated normal females without any history of hemophilia B in the family and 13 unrelated obligate carriers were recruited in the study. Regions of F9 gene were amplified by PCR from genomic DNA of the donors followed by restriction enzyme digestion and/or sequencing as appropriate. Combined informativeness for the markers varied between 52-86% among normal females belonging to different geographical locations of India. Haplotype analysis revealed that the most prevalent haplotype lacked the restriction sites for all five RFLP markers. Screening regions of F9 gene that harbor 10 SNPs reported in dbSNP yielded only two SNPs, which increased the overall informativeness in each population group and heterozygosity in the obligate carriers for the disease from 38% to 69%. Our data show that heterozygosity of commonly used RFLP markers is remarkably variable across different regions of India. Thus prudent selection of the markers based on specific population groups including usage of additional markers is recommended for efficient carrier detection.

Evaluating and Optimizing Online Advertising: Forget the Click, but There Are Good Proxies.

PubMed

Dalessandro, Brian; Hook, Rod; Perlich, Claudia; Provost, Foster

2015-06-01

Online systems promise to improve advertisement targeting via the massive and detailed data available. However, there often is too few data on exactly the outcome of interest, such as purchases, for accurate campaign evaluation and optimization (due to low conversion rates, cold start periods, lack of instrumentation of offline purchases, and long purchase cycles). This paper presents a detailed treatment of proxy modeling, which is based on the identification of a suitable alternative (proxy) target variable when data on the true objective is in short supply (or even completely nonexistent). The paper has a two-fold contribution. First, the potential of proxy modeling is demonstrated clearly, based on a massive-scale experiment across 58 real online advertising campaigns. Second, we assess the value of different specific proxies for evaluating and optimizing online display advertising, showing striking results. The results include bad news and good news. The most commonly cited and used proxy is a click on an ad. The bad news is that across a large number of campaigns, clicks are not good proxies for evaluation or for optimization: clickers do not resemble buyers. The good news is that an alternative sort of proxy performs remarkably well: observed visits to the brand's website. Specifically, predictive models built based on brand site visits-which are much more common than purchases-do a remarkably good job of predicting which browsers will make a purchase. The practical bottom line: evaluating and optimizing campaigns using clicks seems wrongheaded; however, there is an easy and attractive alternative-use a well-chosen site-visit proxy instead.

Resolution of pain after childbirth.

PubMed

Eisenach, James C; Pan, Peter; Smiley, Richard M; Lavand'homme, Patricia; Landau, Ruth; Houle, Timothy T

2013-01-01

Chronic pain after surgery occurs in 10-40% of individuals, including 5-20% of women after cesarean delivery in previous reports. Pain and depression 2 months after childbirth are independently associated with more severe acute post-delivery pain. Here we examine other predictors of pain at 2 months and determine the incidence of pain at 6 and 12 months after childbirth. Following Institutional Review Board approval, 1228 women were interviewed within 36 h of delivery. Of these, 937 (76%) were successfully contacted by telephone at 2 months, and, if they had pain, at 6 and 12 months after delivery. The primary outcome measure was presence of pain which began at the time of delivery. We also generated a model of severity of acute post-delivery pain and 2 month pain and depression. Pain which began at the time of delivery was remarkably rare 6 and 12 months later (1.8% and 0.3% [upper 95% confidence limit, 1.2%], respectively). Past history of pain and degree of tissue damage at delivery accounted for 7.0% and 16.7%, respectively, of one aspect in the variability in acute post-delivery pain. Neither of these factors was associated with incidence of pain 2 months later. Using a definition of new onset pain from delivery, we show a remarkably low incidence of pain 1 yr after childbirth, including those with surgical delivery. Additionally, degree of tissue trauma and history of chronic pain, risk factors for pain 2 months after other surgery, were unimportant to pain 2 months after cesarean or vaginal delivery.

New patterns in human biogeography revealed by networks of contacts between linguistic groups.

PubMed

Capitán, José A; Bock Axelsen, Jacob; Manrubia, Susanna

2015-03-07

Human languages differ broadly in abundance and are distributed highly unevenly on the Earth. In many qualitative and quantitative aspects, they strongly resemble biodiversity distributions. An intriguing and previously unexplored issue is the architecture of the neighbouring relationships between human linguistic groups. Here we construct and characterize these networks of contacts and show that they represent a new kind of spatial network with uncommon structural properties. Remarkably, language networks share a meaningful property with food webs: both are quasi-interval graphs. In food webs, intervality is linked to the existence of a niche space of low dimensionality; in language networks, we show that the unique relevant variable is the area occupied by the speakers of a language. By means of a range model analogous to niche models in ecology, we show that a geometric restriction of perimeter covering by neighbouring linguistic domains explains the structural patterns observed. Our findings may be of interest in the development of models for language dynamics or regarding the propagation of cultural innovations. In relation to species distribution, they pose the question of whether the spatial features of species ranges share architecture, and eventually generating mechanism, with the distribution of human linguistic groups. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

The fear gasping face as a threat display in a Melanesian society

PubMed Central

Crivelli, Carlos; Jarillo, Sergio; Fernández-Dols, José-Miguel

2016-01-01

Theory and research show that humans attribute both emotions and intentions to others on the basis of facial behavior: A gasping face can be seen as showing “fear” and intent to submit. The assumption that such interpretations are pancultural derives largely from Western societies. Here, we report two studies conducted in an indigenous, small-scale Melanesian society with considerable cultural and visual isolation from the West: the Trobrianders of Papua New Guinea. Our multidisciplinary research team spoke the vernacular and had extensive prior fieldwork experience. In study 1, Trobriand adolescents were asked to attribute emotions, social motives, or both to a set of facial displays. Trobrianders showed a mixed and variable attribution pattern, although with much lower agreement than studies of Western samples. Remarkably, the gasping face (traditionally considered a display of fear and submission in the West) was consistently matched to two unpredicted categories: anger and threat. In study 2, adolescents were asked to select the face that was threatening; Trobrianders chose the “fear” gasping face whereas Spaniards chose an “angry” scowling face. Our findings, consistent with functional approaches to animal communication and observations made on threat displays in small-scale societies, challenge the Western assumption that “fear” gasping faces uniformly express fear or signal submission across cultures. PMID:27791137

Positron annihilation study of cavities in black Au films

NASA Astrophysics Data System (ADS)

Melikhova, O.; Čížek, J.; Hruška, P.; Vlček, M.; Procházka, I.; Anwand, W.; Novotný, M.; Bulíř, J.

2017-01-01

Defects in a black Au film were studied using variable energy positron annihilation spectroscopy. Black Au films exhibit porous morphology similar to cauliflower. This type of structure enhances the optical absorption due to a multiple reflections in the micro-cavities. A nanostructured black Au film was compared with conventional smooth Au films with high reflectivity. The black Au film exhibited a remarkably enhanced S-parameter in sub-surface region. This is caused by a narrow para-Positronium contribution to the annihilation peak.

Algae as promising organisms for environment and health

PubMed Central

2011-01-01

Algae, like other plants, produce a variety of remarkable compounds collectively referred to as secondary metabolites. They are synthesized by these organisms at the end of the growth phase and/or due to metabolic alterations induced by environmental stress conditions. Carotenoids, phenolic compounds, phycobiliprotein pigments, polysaccharides and unsaturated fatty acids are same of the algal natural products, which were reported to have variable biological activities, including antioxidant activity, anticancer activity, antimicroabial activity against bacteria-virus-algae-fungi, organic fertilizer and bioremediation potentials. PMID:21862867

Disseminated melioidosis presenting as septic arthritis.

PubMed

Rajadhyaksha, Anjali; Sonawale, Archana; Khare, Shruti; Kalal, Chetan; Jankar, Rahul

2012-06-01

Melioidosis is an infection caused by Burkholderia pseudomallei. The disease is known as a remarkable imitator due to the wide and variable clinical spectrum of its manifestations. Septic arthritis is rare but well-recognized manifestation of this disease. We report a case of melioidosis in a 52 year male with uncontrolled diabetes mellitus (DM) presenting with a rare combination of septic arthritis and abscesses in the chest wall, liver and subcutaneous tissue. The patient responded to prolonged treatment of intravenous ceftazidime followed by oral co-trimoxazole.

Gauge/Gravity Duality

ScienceCinema

Polchinski, Joseph

2017-12-22

Gauge theories, which describe the particle interactions, are well understood, while quantum gravity leads to many puzzles. Remarkably, in recent years we have learned that these are actually dual, the same system written in different variables. On the one hand, this provides our most precise description of quantum gravity, resolves some long-standing paradoxes, and points to new principles. On the other, it gives a new perspective on strong interactions, with surprising connections to other areas of physics. I describe these ideas, and discuss current and future directions.

Partially coherent surface plasmon modes

NASA Astrophysics Data System (ADS)

Niconoff, G. M.; Vara, P. M.; Munoz-Lopez, J.; Juárez-Morales, J. C.; Carbajal-Dominguez, A.

2011-04-01

Elementary long-range plasmon modes are described assuming an exponential dependence of the refractive index in the neighbourhood of the interface dielectric-metal thin film. The study is performed using coupling mode theory. The interference between two long-range plasmon modes generated that way allows the synthesis of surface sinusoidal plasmon modes, which can be considered as completely coherent generalized plasmon modes. These sinusoidal plasmon modes are used for the synthesis of new partially coherent surface plasmon modes, which are obtained by means of an incoherent superposition of sinusoidal plasmon modes where the period of each one is considered as a random variable. The kinds of surface modes generated have an easily tuneable profile controlled by means of the probability density function associated to the period. We show that partially coherent plasmon modes have the remarkable property to control the length of propagation which is a notable feature respect to the completely coherent surface plasmon mode. The numerical simulation for sinusoidal, Bessel, Gaussian and Dark Hollow plasmon modes are presented.

Multi-Lagrangians for integrable systems

NASA Astrophysics Data System (ADS)

Nutku, Y.; Pavlov, M. V.

2002-03-01

We propose a general scheme to construct multiple Lagrangians for completely integrable nonlinear evolution equations that admit multi-Hamiltonian structure. The recursion operator plays a fundamental role in this construction. We use a conserved quantity higher/lower than the Hamiltonian in the potential part of the new Lagrangian and determine the corresponding kinetic terms by generating the appropriate momentum map. This leads to some remarkable new developments. We show that nonlinear evolutionary systems that admit N-fold first order local Hamiltonian structure can be cast into variational form with 2N-1 Lagrangians which will be local functionals of Clebsch potentials. This number increases to 3N-2 when the Miura transformation is invertible. Furthermore we construct a new Lagrangian for polytropic gas dynamics in 1+1 dimensions which is a free, local functional of the physical field variables, namely density and velocity, thus dispensing with the necessity of introducing Clebsch potentials entirely. This is a consequence of bi-Hamiltonian structure with a compatible pair of first and third order Hamiltonian operators derived from Sheftel's recursion operator.

The influence of indoxyl sulfate and ammonium on the autofluorescence of human urine.

PubMed

Perinchery, Sandeep Menon; Kuzhiumparambil, Unnikrishnan; Vemulpad, Subramanyam; Goldys, Ewa M

2010-01-15

Despite biological variability the spectral characteristics of undiluted human urine show relatively low autofluorescence at short UV (250-300nm) excitation. However with dilution the fluorescence intensity remarkably increases. This paper examines the mechanisms behind this effect, by using excitation-emission matrices. Corrections for the inner filter effect were made for improved understanding of the spectral patterns. We focused on three major fluorophores (tryptophan, indoxyl sulfate and 5-hydroxyindole-3-acetate) that are excited at these wavelengths, and whose content in urine is strongly linked with various health conditions. Their fluorescence was studied both individually and in combinations. We also examined the effect of ammonium on the fluorescence of these major fluorophores individually and in combinations. Through these studies we have identified the leading effects that reduce the UV fluorescence, namely higher concentration of indoxyl sulfate producing the inner filter effect and concentration quenching and quenching of fluorophores by ammonium. This result will assist in broader utilisation of UV fluorescence in medical diagnostics.

Genetic variation in glia-neuron signalling modulates ageing rate.

PubMed

Yin, Jiang-An; Gao, Ge; Liu, Xi-Juan; Hao, Zi-Qian; Li, Kai; Kang, Xin-Lei; Li, Hong; Shan, Yuan-Hong; Hu, Wen-Li; Li, Hai-Peng; Cai, Shi-Qing

2017-11-08

The rate of behavioural decline in the ageing population is remarkably variable among individuals. Despite the considerable interest in studying natural variation in ageing rate to identify factors that control healthy ageing, no such factor has yet been found. Here we report a genetic basis for variation in ageing rates in Caenorhabditis elegans. We find that C. elegans isolates show diverse lifespan and age-related declines in virility, pharyngeal pumping, and locomotion. DNA polymorphisms in a novel peptide-coding gene, named regulatory-gene-for-behavioural-ageing-1 (rgba-1), and the neuropeptide receptor gene npr-28 influence the rate of age-related decline of worm mating behaviour; these two genes might have been subjected to recent selective sweeps. Glia-derived RGBA-1 activates NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration. This signalling involves the SIR-2.1-dependent activation of the mitochondrial unfolded protein response, a pathway that modulates ageing. Thus, natural variation in neuropeptide-mediated glia-neuron signalling modulates the rate of ageing in C. elegans.

The use of limpets as monitor of PAHs pollution in the Cantabrian coast

NASA Astrophysics Data System (ADS)

Bartolomé, L.; Bustamante, M.; Navarro, P.; Tajadura, J.; Gorostiaga, J. M.; Díez, I.; Zuloaga, O.; Etxebarria, N.

2011-11-01

The concentrations of 24 parental and methylated polycyclic aromatic hydrocarbon (PAH) levels in common limpet ( Patella vulgata) were measured in 15 coastal localities of the southern Bay of Biscay and 2 sites per locality for 2 years (spring and autumn of 2004 and 2005, respectively). Although the average concentrations shown a wide variability among the sites and the season, several sites showed a remarkable high concentration (PAH tot>900 ng g -1 d.w.) or medium (300-800 ng g -1 d.w) levels, but in most of the cases the initial high concentrations decreased sharply from one campaign to the following. Moreover, based on ratios of individual isomers concentration, petrogenic and pyrolitic sources were distinguished suggesting more than one source. Finally, based on the results of this work and comparing with previously reported data, it can concluded that limpets can be used as sentinel organisms in coastal environmental monitoring, even when oil spills are involved.

The Aeronomy of Ice in the Mesosphere Mission: Science Results After Three PMC Seasons

NASA Astrophysics Data System (ADS)

Russell, J. M.; Bailey, S. M.; Rusch, D.; Thomas, G. E.; Gordley, L. L.; Hervig, M. E.; Horanyi, M.

2008-12-01

The Aeronomy of Ice in the Mesosphere (AIM) satellite was launched from Vandenberg Air Force Base in California at 1:26:03 PDT on April 25, 2007 becoming the first satellite mission dedicated to the study of Polar Mesospheric Clouds (PMCs). A Pegasus XL rocket launched the satellite into a near perfect 600 km sun synchronous circular orbit. AIM carries three instruments - a nadir imager, a solar occultation sounder and an in-situ cosmic dust detector. Brief instrument descriptions, data quality and key science results will be presented. AIM has observed three PMC seasons at this point in time including two in the northern hemisphere (2007 and 2008) and one in the south (2007/2008). The observations are providing extraordinary detail on the horizontal and vertical extent of PMCs and their variability. Results show that the mesospheric ice layer extends up to the mesopause, there are voids in the PMC fields of both hemispheres and for the two northern seasons, temporal trends are remarkably similar.

Infectious polymorphic toxins delivered by outer membrane exchange discriminate kin in myxobacteria.

PubMed

Vassallo, Christopher N; Cao, Pengbo; Conklin, Austin; Finkelstein, Hayley; Hayes, Christopher S; Wall, Daniel

2017-08-18

Myxobacteria are known for complex social behaviors including outer membrane exchange (OME), in which cells exchange large amounts of outer membrane lipids and proteins upon contact. The TraA cell surface receptor selects OME partners based on a variable domain. However, traA polymorphism alone is not sufficient to precisely discriminate kin. Here, we report a novel family of OME-delivered toxins that promote kin discrimination of OME partners. These SitA lipoprotein toxins are polymorphic and widespread in myxobacteria. Each sitA is associated with a cognate sitI immunity gene, and in some cases a sitB accessory gene. Remarkably, we show that SitA is transferred serially between target cells, allowing the toxins to move cell-to-cell like an infectious agent. Consequently, SitA toxins define strong identity barriers between strains and likely contribute to population structure, maintenance of cooperation, and strain diversification. Moreover, these results highlight the diversity of systems evolved to deliver toxins between bacteria.

Studying the Fading Infrared Evolution of SN 1978K

NASA Astrophysics Data System (ADS)

Smith, Ian

2018-05-01

SN 1978K in the nearby barred spiral galaxy NGC 1313 is a remarkable Type IIn supernova that remains bright at X-ray through radio wavelengths 40 years after its explosion. Our long-term program of multi-wavelength observations is probing the dense medium that was ejected by the progenitor star, possibly a Luminous Blue Variable. Only SN 1978K was detected in a search for warm dust in supernovae in the transitional phase (age 10-100 years). Thus SN 1978K is a prime target for studying whether supernovae such as this are important contributors to the Universal dust budget and how the dust reacts to the strong and varying UV and X-ray emissions. Our analysis of the previous Spitzer observations shows a rapid fading of the warm dust emission. Here we request one Spitzer observation at 3.6 and 4.5 microns to continue to monitor the infrared evolution. This will serve as a bridge to future monitoring with JWST.

Biomimetic synthesis of silver nanoparticles and evaluation of their catalytic activity towards degradation of methyl orange

NASA Astrophysics Data System (ADS)

Manjari Mishra, Pravat; Bihari Pani, Khirod

2017-11-01

This paper described the significant effect of process variables like reductant concentrations, substrate concentration, reaction pH and reaction temperature on the size, morphology and yield of the silver nanoparticles (AgNPs) synthesized using aqueous leaf extract of a medicinal plant Momordica charantia (Bitter guard). By means of UV-vis spectroscopy, XRD analysis, TEM analysis and Fluorescence analysis, it is observed that the reaction solution containing 10-3 M of AgNO3 of pH 5.3  +  10 ml of aqueous leaf extract at normal room temperature, was optimum for synthesis of stable, polydisperse, predominantly spherical AgNPs with average size of 12.15 nm. FT-IR and TEM studies confirmed the stability of AgNPs was due to the capping of phytoconstituents present in the leaf extract. The aqueous solution of leaf extract containing AgNPs showed remarkable catalytic activity towards degradation of methyl orange (MO) in aqueous medium.

Genetic diversity and temporal variation of the marine Synechococcus community in the subtropical coastal waters of Hong Kong.

PubMed

Jing, Hongmei; Zhang, Rui; Pointing, Stephen B; Liu, Hongbin; Qian, Peiyuan

2009-03-01

The phylogenetic diversity of the marine Synechococcus community in the subtropical coastal waters of Hong Kong, China, was examined through intergenic transcribed spacer clone libraries. All the sequences obtained fell within both marine cluster A (MC-A) and B (MC-B), with MC-A phylotypes dominating throughout the year. Distinct phylogenetic lineages specific to Hong Kong waters were detected from both MC-A and MC-B. The highest Synechococcus community diversity occurred in December, but the highest Synechococcus abundance occurred in August. On the other hand, both the abundance and diversity of Synechococcus showed a minimum in February. The remarkable seasonal variations of Synechococcus diversity observed were likely the result of the changes of hydrographic condition modulated by monsoons. Principal component analysis revealed that the in situ abiotic water characteristics, especially salinity and water turbidity, explained much of the variability of the marine Synechococcus population diversity in Hong Kong coastal waters. In addition, the temporal changes of Synechococcus abundance were largely driven by water temperature.

Discovery of a Nonblazar Gamma-Ray Transient Source Near the Galactic Plane: GRO J1838-04

NASA Technical Reports Server (NTRS)

Tavani, M.; Oliversen, Ronald (Technical Monitor)

2001-01-01

We report the discovery of a remarkable gamma-ray transient source near the Galactic plane, GRO J1838-04. This source was serendipitously discovered by EGRET in 1995 June with a peak intensity of approx. (4 +/- 1) x 10(exp -6) photons/sq cm s (for photon energies larger than 100 MeV) and a 5.9 sigma significance. At that time, GRO J1838-04 was the second brightest gamma-ray source in the sky. A subsequent EGRET pointing in 1995 late September detected the source at a flux smaller than its peak value by a factor of approx. 7. We determine that no radio-loud spectrally flat blazar is within the error box of GRO J1838-04. We discuss the origin of the gamma-ray transient source and show that interpretations in terms of active galactic nuclei or isolated pulsars are highly problematic. GRO J1838-04 provides strong evidence for the existence of a new class of variable gamma-ray sources.

Renormalization-group theory for finite-size scaling in extreme statistics

NASA Astrophysics Data System (ADS)

Györgyi, G.; Moloney, N. R.; Ozogány, K.; Rácz, Z.; Droz, M.

2010-04-01

We present a renormalization-group (RG) approach to explain universal features of extreme statistics applied here to independent identically distributed variables. The outlines of the theory have been described in a previous paper, the main result being that finite-size shape corrections to the limit distribution can be obtained from a linearization of the RG transformation near a fixed point, leading to the computation of stable perturbations as eigenfunctions. Here we show details of the RG theory which exhibit remarkable similarities to the RG known in statistical physics. Besides the fixed points explaining universality, and the least stable eigendirections accounting for convergence rates and shape corrections, the similarities include marginally stable perturbations which turn out to be generic for the Fisher-Tippett-Gumbel class. Distribution functions containing unstable perturbations are also considered. We find that, after a transitory divergence, they return to the universal fixed line at the same or at a different point depending on the type of perturbation.

Rotor-stator molecular crystals of fullerenes with cubane.

PubMed

Pekker, Sándor; Kováts, Eva; Oszlányi, Gábor; Bényei, Gyula; Klupp, Gyöngyi; Bortel, Gábor; Jalsovszky, István; Jakab, Emma; Borondics, Ferenc; Kamarás, Katalin; Bokor, Mónika; Kriza, György; Tompa, Kálmán; Faigel, Gyula

2005-10-01

Cubane (C8H8) and fullerene (C60) are famous cage molecules with shapes of platonic or archimedean solids. Their remarkable chemical and solid-state properties have induced great scientific interest. Both materials form polymorphic crystals of molecules with variable orientational ordering. The idea of intercalating fullerene with cubane was raised several years ago but no attempts at preparation have been reported. Here we show that C60 and similarly C70 form high-symmetry molecular crystals with cubane owing to topological molecular recognition between the convex surface of fullerenes and the concave cubane. Static cubane occupies the octahedral voids of the face-centred-cubic structures and acts as a bearing between the rotating fullerene molecules. The smooth contact of the rotor and stator molecules decreases significantly the temperature of orientational ordering. These materials have great topochemical importance: at elevated temperatures they transform to high-stability covalent derivatives although preserving their crystalline appearance. The size-dependent molecular recognition promises selective formation of related structures with higher fullerenes and/or substituted cubanes.

Mesolimbic confidence signals guide perceptual learning in the absence of external feedback

PubMed Central

Guggenmos, Matthias; Wilbertz, Gregor; Hebart, Martin N; Sterzer, Philipp

2016-01-01

It is well established that learning can occur without external feedback, yet normative reinforcement learning theories have difficulties explaining such instances of learning. Here, we propose that human observers are capable of generating their own feedback signals by monitoring internal decision variables. We investigated this hypothesis in a visual perceptual learning task using fMRI and confidence reports as a measure for this monitoring process. Employing a novel computational model in which learning is guided by confidence-based reinforcement signals, we found that mesolimbic brain areas encoded both anticipation and prediction error of confidence—in remarkable similarity to previous findings for external reward-based feedback. We demonstrate that the model accounts for choice and confidence reports and show that the mesolimbic confidence prediction error modulation derived through the model predicts individual learning success. These results provide a mechanistic neurobiological explanation for learning without external feedback by augmenting reinforcement models with confidence-based feedback. DOI: http://dx.doi.org/10.7554/eLife.13388.001 PMID:27021283

An X-ray Investigation of the NGC 346 Field in the SMC (2): The Field Population

NASA Technical Reports Server (NTRS)

Naze, Y.; Hartwell, J. M.; Stevens, I. R.; Manfroid, J.; Marchenko. S.; Corcoran, M. F.; Moffat, A. F. J.; Skalkowski, G.; White, Nicholas E. (Technical Monitor)

2002-01-01

We present results from a Chandra observation of the NGC 346 cluster, the ionizing source of N66, the most luminous H II region and the largest star formation region in the SMC. In the first part of this investigation, we have analysed the X-ray properties of the cluster itself and the remarkable star HD 5980. But the field contains additional objects of interest. In total, 79 X-ray point sources were detected in the Chandra observation and we investigate here their characteristics in details. The sources possess rather high HRs, and their cumulative luminosity function is steeper than the SMC's trend. Their absorption columns suggest that most of the sources belong to NGC 346. Using new UBVRI imaging with the ESO 2.2m telescope, we also discovered possible counterparts for 36 of these X-ray sources. Finally, some objects show X-ray and/or optical variability, and thus need further monitoring.

Nonlinear Response of the Stratosphere and the North Atlantic-European Climate to Global Warming

NASA Astrophysics Data System (ADS)

Manzini, E.; Karpechko, A. Yu.; Kornblueh, L.

2018-05-01

The response of the northern winter atmospheric circulation for two consecutive global warming periods of 2 K is examined in a grand ensemble (68 members) of idealized CO2 increase experiments performed with the same climate model. The comparison of the atmospheric responses for the two periods shows remarkable differences, indicating the nonlinearity of the response. The nonlinear signature of the atmospheric and surface responses is reminiscent of the positive phase of the annular mode of variability. The stratospheric vortex response shifts from an easterly wind change for the first 2 K to a westerly wind change for the second 2 K. The North Atlantic storm track shifts poleward only in the second period. A weaker November Arctic amplification during the second period suggests that differences in Arctic sea ice changes can act to trigger the atmospheric nonlinear response. Stratosphere-troposphere coupling thereafter can provide for the persistence of this nonlinearity throughout the winter.

Exocomet Signatures Around the A-shell Star Phi Leonis

NASA Technical Reports Server (NTRS)

Eiroa, C.; Rebollido, I.; Montesinos, B.; Villaver, E.; Absil, O.; Henning, Th.; Bayo, A.; Canovas, H.; Carmona, A.; Chen, Ch.;

To transfer or not to transfer? Kinematics and laterality quotient predict interlimb transfer of motor learning

PubMed Central

Lefumat, Hannah Z.; Vercher, Jean-Louis; Miall, R. Chris; Cole, Jonathan; Buloup, Frank; Bringoux, Lionel; Bourdin, Christophe

2015-01-01

Humans can remarkably adapt their motor behavior to novel environmental conditions, yet it remains unclear which factors enable us to transfer what we have learned with one limb to the other. Here we tested the hypothesis that interlimb transfer of sensorimotor adaptation is determined by environmental conditions but also by individual characteristics. We specifically examined the adaptation of unconstrained reaching movements to a novel Coriolis, velocity-dependent force field. Right-handed subjects sat at the center of a rotating platform and performed forward reaching movements with the upper limb toward flashed visual targets in prerotation, per-rotation (i.e., adaptation), and postrotation tests. Here only the dominant arm was used during adaptation and interlimb transfer was assessed by comparing performance of the nondominant arm before and after dominant-arm adaptation. Vision and no-vision conditions did not significantly influence interlimb transfer of trajectory adaptation, which on average was significant but limited. We uncovered a substantial heterogeneity of interlimb transfer across subjects and found that interlimb transfer can be qualitatively and quantitatively predicted for each healthy young individual. A classifier showed that in our study, interlimb transfer could be predicted based on the subject's task performance, most notably motor variability during learning, and his or her laterality quotient. Positive correlations suggested that variability of motor performance and lateralization of arm movement control facilitate interlimb transfer. We further show that these individual characteristics can predict the presence and the magnitude of interlimb transfer of left-handers. Overall, this study suggests that individual characteristics shape the way the nervous system can generalize motor learning. PMID:26334018

Dentine morphology of Atapuerca-Sima de los Huesos lower molars: Evolutionary implications through three-dimensional geometric morphometric analysis.

PubMed

Hanegraef, Hester; Martinón-Torres, María; Martínez de Pinillos, Marina; Martín-Francés, Laura; Vialet, Amélie; Arsuaga, Juan Luis; Bermúdez de Castro, José María

2018-06-01

This study aims to explore the affinities of the Sima de los Huesos (SH) population in relation to Homo neanderthalensis, Arago, and early and contemporary Homo sapiens. By characterizing SH intra-population variation, we test current models to explain the Neanderthal origins. Three-dimensional reconstructions of dentine surfaces of lower first and second molars were produced by micro-computed tomography. Landmarks and sliding semilandmarks were subjected to generalized Procrustes analysis and principal components analysis. SH is often similar in shape to Neanderthals, and both groups are generally discernible from Homo sapiens. For example, the crown height of SH and Neanderthals is lower than for modern humans. Differences in the presence of a mid-trigonid crest are also observed, with contemporary Homo sapiens usually lacking this feature. Although SH and Neanderthals show strong affinities, they can be discriminated based on certain traits. SH individuals are characterized by a lower intra-population variability, and show a derived dental reduction in lower second molars compared to Neanderthals. SH also differs in morphological features from specimens that are often classified as Homo heidelbergensis, such as a lower crown height and less pronounced mid-trigonid crest in the Arago fossils. Our results are compatible with the idea that multiple evolutionary lineages or populations coexisted in Europe during the Middle Pleistocene, with the SH paradigm phylogenetically closer to Homo neanderthalensis. Further research could support the possibility of SH as a separate taxon. Alternatively, SH could be a subspecies of Neanderthals, with the variability of this clade being remarkably higher than previously thought. © 2018 Wiley Periodicals, Inc.

Sound radiation and wing mechanics in stridulating field crickets (Orthoptera: Gryllidae).

PubMed

Montealegre-Z, Fernando; Jonsson, Thorin; Robert, Daniel

2011-06-15

Male field crickets emit pure-tone mating calls by rubbing their wings together. Acoustic radiation is produced by rapid oscillations of the wings, as the right wing (RW), bearing a file, is swept across the plectrum borne on the left wing (LW). Earlier work found the natural resonant frequency (f(o)) of individual wings to be different, but there is no consensus on the origin of these differences. Previous studies suggested that the frequency along the song pulse is controlled independently by each wing. It has also been argued that the stridulatory file has a variable f(o) and that the frequency modulation observed in most species is associated with this variability. To test these two hypotheses, a method was developed for the non-contact measurement of wing vibrations during singing in actively stridulating Gryllus bimaculatus. Using focal microinjection of the neuroactivator eserine into the cricket's brain to elicit stridulation and micro-scanning laser Doppler vibrometry, we monitored wing vibration in actively singing insects. The results show significantly lower f(o) in LWs compared with RWs, with the LW f(o) being identical to the sound carrier frequency (N=44). But during stridulation, the two wings resonate at one identical frequency, the song carrier frequency, with the LW dominating in amplitude response. These measurements also demonstrate that the stridulatory file is a constant resonator, as no variation was observed in f(o) along the file during sound radiation. Our findings show that, as they engage in stridulation, cricket wings work as coupled oscillators that together control the mechanical oscillations generating the remarkably pure species-specific song.

Temperament and job stress in Japanese company employees.

PubMed

Sakai, Y; Akiyama, T; Miyake, Y; Kawamura, Y; Tsuda, H; Kurabayashi, L; Tominaga, M; Noda, T; Akiskal, K; Akiskal, H

2005-03-01

This study aims to demonstrate the relevance of temperament to job stress. The subjects were 848 male and 366 female Japanese company employees. Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A) and Munich Personality Test (MPT) were administered to assess temperaments, and the NIOSH Generic Job Stress Questionnaire (GJSQ) to assess job stress. We used hierarchical multiple linear regression analysis in order to demonstrate whether temperament variables added any unique variance after controlling the effects of other predictors such as gender, age and job rank. In all subscales of the GJSQ, temperament predicted a large share of the variance in job stress. Remarkably, for interpersonal relationship stressors, the temperament variables added greater variance than that predicted by gender, age and job rank. Summary of the hierarchical linear regression analysis showed that the irritable temperament was associated with the most prominent vulnerability, followed by cyclothymic and anxious temperaments. The schizoid temperament had difficulty in the area of social support. On the other hand, the hyperthymic temperament displayed significant robustness in facing most job stressors; the melancholic type showed a similar pattern to a lesser degree. The findings may be different in a clinical Japanese sample, or a cohort of healthy employees from a different cultural background. Temperament influences job stress significantly-indeed, it impacts on such stress with greater magnitude than age, gender and job rank in most areas examined. Temperament influences interpersonal relationship stressors more than workload-related stressors. Interestingly, in line with previous clinical and theoretical formulations, the hyperthymic and melancholic types actually appear to be "hyper-adapted" to the workplace.

A STUDY OF BROADBAND FARADAY ROTATION AND POLARIZATION BEHAVIOR OVER 1.3–10 GHz IN 36 DISCRETE RADIO SOURCES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, C. S.; Gaensler, B. M.; Feain, I. J., E-mail: craiga@physics.usyd.edu.au

We present a broadband polarization analysis of 36 discrete polarized radio sources over a very broad, densely sampled frequency band. Our sample was selected on the basis of polarization behavior apparent in narrowband archival data at 1.4 GHz: half the sample shows complicated frequency-dependent polarization behavior (i.e., Faraday complexity) at these frequencies, while half shows comparatively simple behavior (i.e., they appear Faraday simple ). We re-observed the sample using the Australia Telescope Compact Array in full polarization, with 6 GHz of densely sampled frequency coverage spanning 1.3–10 GHz. We have devised a general polarization modeling technique that allows us tomore » identify multiple polarized emission components in a source, and to characterize their properties. We detect Faraday complex behavior in almost every source in our sample. Several sources exhibit particularly remarkable polarization behavior. By comparing our new and archival data, we have identified temporal variability in the broadband integrated polarization spectra of some sources. In a number of cases, the characteristics of the polarized emission components, including the range of Faraday depths over which they emit, their temporal variability, spectral index, and the linear extent of the source, allow us to argue that the spectropolarimetric data encode information about the magneto-ionic environment of active galactic nuclei themselves. Furthermore, the data place direct constraints on the geometry and magneto-ionic structure of this material. We discuss the consequences of restricted frequency bands on the detection and interpretation of polarization structures, and the implications for upcoming spectropolarimetric surveys.« less

Auditory and audio-visual processing in patients with cochlear, auditory brainstem, and auditory midbrain implants: An EEG study.

PubMed

Schierholz, Irina; Finke, Mareike; Kral, Andrej; Büchner, Andreas; Rach, Stefan; Lenarz, Thomas; Dengler, Reinhard; Sandmann, Pascale

2017-04-01

There is substantial variability in speech recognition ability across patients with cochlear implants (CIs), auditory brainstem implants (ABIs), and auditory midbrain implants (AMIs). To better understand how this variability is related to central processing differences, the current electroencephalography (EEG) study compared hearing abilities and auditory-cortex activation in patients with electrical stimulation at different sites of the auditory pathway. Three different groups of patients with auditory implants (Hannover Medical School; ABI: n = 6, CI: n = 6; AMI: n = 2) performed a speeded response task and a speech recognition test with auditory, visual, and audio-visual stimuli. Behavioral performance and cortical processing of auditory and audio-visual stimuli were compared between groups. ABI and AMI patients showed prolonged response times on auditory and audio-visual stimuli compared with NH listeners and CI patients. This was confirmed by prolonged N1 latencies and reduced N1 amplitudes in ABI and AMI patients. However, patients with central auditory implants showed a remarkable gain in performance when visual and auditory input was combined, in both speech and non-speech conditions, which was reflected by a strong visual modulation of auditory-cortex activation in these individuals. In sum, the results suggest that the behavioral improvement for audio-visual conditions in central auditory implant patients is based on enhanced audio-visual interactions in the auditory cortex. Their findings may provide important implications for the optimization of electrical stimulation and rehabilitation strategies in patients with central auditory prostheses. Hum Brain Mapp 38:2206-2225, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

State Variation in Medicaid Reimbursements for Orthopaedic Surgery.

PubMed

Lalezari, Ramin M; Pozen, Alexis; Dy, Christopher J

2018-02-07

Medicaid reimbursements are determined by each state and are subject to variability. We sought to quantify this variation for commonly performed inpatient orthopaedic procedures. The 10 most commonly performed inpatient orthopaedic procedures, as ranked by the Healthcare Cost and Utilization Project (HCUP) National Inpatient Sample, were identified for study. Medicaid reimbursement amounts for those procedures were benchmarked to state Medicare reimbursement amounts in 3 ways: (1) ratio, (2) dollar difference, and (3) dollar difference divided by the relative value unit (RVU) amount. Variability was quantified by determining the range and coefficient of variation for those reimbursement amounts. The range of variability of Medicaid reimbursements among states exceeded $1,500 for all 10 procedures. The coefficients of variation ranged from 0.32 (hip hemiarthroplasty) to 0.57 (posterior or posterolateral lumbar interbody arthrodesis) (a higher coefficient indicates greater variability), compared with 0.07 for Medicare reimbursements for all 10 procedures. Adjusted as a dollar difference between Medicaid and Medicare per RVU, the median values ranged from -$8/RVU (total knee arthroplasty) to -$17/RVU (open reduction and internal fixation of the femur). Variability of Medicaid reimbursement for inpatient orthopaedic procedures among states is substantial. This variation becomes especially remarkable given recent policy shifts toward focusing reimbursements on value.

Ablation of aluminum nitride films by nanosecond and femtosecond laser pulses

NASA Astrophysics Data System (ADS)

Gruzdev, Vitaly; Tzou, Robert; Salakhutdinov, Ildar; Danylyuk, Yuriy; McCullen, Erik; Auner, Gregory

2009-02-01

We present results of comparative study of laser-induced ablation of AlN films with variable content of oxygen as a surface-doping element. The films deposited on sapphire substrate were ablated by a single nanosecond pulse at wavelength 248 nm, and by a single femtosecond pulse at wavelength 775 nm in air at normal pressure. Ablation craters were inspected by AFM and Nomarski high-resolution microscope. Irradiation by nanosecond pulses leads to a significant removal of material accompanied by extensive thermal effects, chemical modification of the films around the ablation craters and formation of specific defect structures next to the craters. Remarkable feature of the nanosecond experiments was total absence of thermo-mechanical fracturing near the edges of ablation craters. The femtosecond pulses produced very gentle ablation removing sub-micrometer layers of the films. No remarkable signs of thermal, thermo-mechanical or chemical effects were found on the films after the femtosecond ablation. We discuss mechanisms responsible for the specific ablation effects and morphology of the ablation craters.

The long view: Causes of climate change over the instrumental period

NASA Astrophysics Data System (ADS)

Hegerl, G. C.; Schurer, A. P.; Polson, D.; Iles, C. E.; Bronnimann, S.

2016-12-01

The period of instrumentally recorded data has seen remarkable changes in climate, with periods of rapid warming, and periods of stagnation or cooling. A recent analysis of the observed temperature change from the instrumental record confirms that most of the warming recorded since the middle of the 20rst century has been caused by human influences, but shows large uncertainty in separating greenhouse gas from aerosol response if accounting for model uncertainty. The contribution by natural forcing and internal variability to the recent warming is estimated to be small, but becomes more important when analysing climate change over earlier or shorter time periods. For example, the enigmatic early 20th century warming was a period of strong climate anomalies, including the US dustbowl drought and exceptional heat waves, and pronounced Arctic warming. Attribution results suggests that about half of the global warming 1901-1950 was forced by greenhouse gases increases, with an anomalously strong contribution by climate variability, and contributions by natural forcing. Long term variations in circulation are important for some regional climate anomalies. Precipitation is important for impacts of climate change and precipitation changes are uncertain in models. Analysis of the instrumental record suggests a human influence on mean and heavy precipitation, and supports climate model estimates of the spatial pattern of precipitation sensitivity to warming. Broadly, and particularly over ocean, wet regions are getting wetter and dry regions are getting drier. In conclusion, the historical record provides evidence for a strong response to external forcings, supports climate models, and raises questions about multi-decadal variability.

The Remarkable Afterglow of GRB 061007: Implications for Optical Flashes and GRB Fireballs

NASA Astrophysics Data System (ADS)

Mundell, C. G.; Melandri, A.; Guidorzi, C.; Kobayashi, S.; Steele, I. A.; Malesani, D.; Amati, L.; D'Avanzo, P.; Bersier, D. F.; Gomboc, A.; Rol, E.; Bode, M. F.; Carter, D.; Mottram, C. J.; Monfardini, A.; Smith, R. J.; Malhotra, S.; Wang, J.; Bannister, N.; O'Brien, P. T.; Tanvir, N. R.

2007-05-01

We present a multiwavelength analysis of Swift GRB 061007. The 2 m robotic Faulkes Telescope South began observing 137 s after the onset of the γ-ray emission, when the optical counterpart was already decaying from R~10.3 mag, and continued observing for the next 5.5 hr. These observations begin during the final γ-ray flare and continue through and beyond a long, soft tail of γ-ray emission whose flux shows an underlying simple power-law decay identical to that seen at optical and X-ray wavelengths, with temporal slope α~1.7 (F~t-α). This remarkably simple decay in all of these bands is rare for Swift bursts, which often show much more complex light curves. We suggest the afterglow emission begins as early as 30-100 s and is contemporaneous with the ongoing variable prompt emission from the central engine, but originates from a physically distinct region dominated by the forward shock. The observed multiwavelength evolution of GRB 061007 is explained by an expanding fireball whose optical, X-ray, and late-time γ-ray emission is dominated by emission from a forward shock with typical synchrotron frequency, νm, that is already below the optical band as early as t=137 s and a cooling frequency, νc, above the X-ray band to at least t=105 s. In contrast, the typical frequency of the reverse shock lies in the radio band at early time. We suggest that the unexpected lack of bright optical flashes from the majority of Swift GRBs may be explained with a low νm originating from small microphysics parameters, ɛe and ɛB. Finally, the optical light curves imply a minimum jet opening angle θ=4.7deg, and no X-ray jet break before t~106 s makes GRB 061007 a secure outlier to spectral energy correlations.

Remarkable Improvement of Shape-Memory Effect in a Co-31Ni-3Si Alloy by Ausforming

NASA Astrophysics Data System (ADS)

Sun, Jiangwei; Wang, Shanling; Yan, Zhiwei; Peng, Huabei; Wen, Yuhua

2015-04-01

In order to improve the shape-memory effect (SME) in Co-Ni alloys, the influence of ausforming temperature on the SME, microstructures, and mechanical behavior in a Co-31Ni-3Si alloy was studied. The results show that the ausforming at 1073 K (800 °C) could remarkably improve the SME in Co-31Ni-3Si alloy. A large recovery strain of 2.3 pct was obtained after bent by 3.7 pct at 77 K (-196 °C). The increase of yield strength and the decrease of the critical stress for the stress-induced gamma to epsilon martensitc transformation are responsible for the remarkable improvement of SME. The results indirectly showed that the SME in Co-Ni alloys results from the stress-induced gamma to epsilon martensitic transformation, and their low yield strength account for their poor SME. It can be expected that the strengthening of matrix by other methods, such as solution, dispersion, and grain refinement hardening, will improve the SME of Co-Ni alloys.

Exploring radar and lightning variables associated with the Lightning Jump. Can we predict the size of the hail?

NASA Astrophysics Data System (ADS)

Farnell, C.; Rigo, T.; Pineda, N.

2018-04-01

Severe weather regularly hits the Lleida Plain (western part of Catalonia, NE of Iberian Peninsula), causing important damage to the local agriculture. In order to help severe weather surveillance tasks, the Meteorological Service of Catalonia (SMC) implemented in 2016 the Lightning Jump (LJ) algorithm as operative warning tool after an exhaustive validation phase of several months. The present study delves into the analysis of the relationship between Lightning Jump alerts and hail occurrence, through the analysis of lightning and radar variables in the moment when the warning is issued. Overall, the study has consisted of the analysis of 149 cases, grouping them into two categories according to hail size: small and large hail, with a threshold of 2 cm of diameter. The thunderstorms related to big sized hail presented remarkable differences in some of the variables analysed that could help forecast the size of hail when the LJ alert is triggered. Moreover, other variables have been allowed to observe and to corroborate how the LJ algorithm works during the 13 min before the warning is triggered.

Driving self-assembly and emergent dynamics in colloidal suspensions by time-dependent magnetic fields

DOE PAGES

Martin, James E.; Snezhko, Alexey

2013-11-05

In this review we discuss recent research on driving self assembly of magnetic particle suspensions subjected to alternating magnetic fields. The variety of structures and effects that can be induced in such systems is remarkably broad due to the large number of variables involved. The alternating field can be uniaxial, biaxial or triaxial, the particles can be spherical or anisometric, and the suspension can be dispersed throughout a volume or confined to a soft interface. In the simplest case the field drives the static or quasi-static assembly of unusual particle structures, such as sheets, networks and open-cell foams. More complex,more » emergent collective behaviors evolve in systems that can follow the time-dependent field vector. In these cases energy is continuously injected into the system and striking °ow patterns and structures can arise. In fluid volumes these include the formation of advection and vortex lattices. At air-liquid and liquid-liquid interfaces striking dynamic particle assemblies emerge due to the particle-mediated coupling of the applied field to surface excitations. These out-of-equilibrium interface assemblies exhibit a number of remarkable phenomena, including self-propulsion and surface mixing. In addition to discussing various methods of driven self assembly in magnetic suspensions, some of the remarkable properties of these novel materials are described.« less

A deep learning framework to discern and count microscopic nematode eggs.

PubMed

Akintayo, Adedotun; Tylka, Gregory L; Singh, Asheesh K; Ganapathysubramanian, Baskar; Singh, Arti; Sarkar, Soumik

2018-06-14

In order to identify and control the menace of destructive pests via microscopic image-based identification state-of-the art deep learning architecture is demonstrated on the parasitic worm, the soybean cyst nematode (SCN), Heterodera glycines. Soybean yield loss is negatively correlated with the density of SCN eggs that are present in the soil. While there has been progress in automating extraction of egg-filled cysts and eggs from soil samples counting SCN eggs obtained from soil samples using computer vision techniques has proven to be an extremely difficult challenge. Here we show that a deep learning architecture developed for rare object identification in clutter-filled images can identify and count the SCN eggs. The architecture is trained with expert-labeled data to effectively build a machine learning model for quantifying SCN eggs via microscopic image analysis. We show dramatic improvements in the quantification time of eggs while maintaining human-level accuracy and avoiding inter-rater and intra-rater variabilities. The nematode eggs are correctly identified even in complex, debris-filled images that are often difficult for experts to identify quickly. Our results illustrate the remarkable promise of applying deep learning approaches to phenotyping for pest assessment and management.

Vegetation dynamics during the Last Interglacial-Glacial cycle in the Arno coastal plain (Tuscany, western Italy): location of a new tree refuge

NASA Astrophysics Data System (ADS)

Lucchi, M. Ricci

2008-12-01

Pollen analysis of the pre-Last Glacial Maximum succession of a 105 m-long continuous core from Tirrenia (Tuscany) provides evidence for the existence of an area of relatively high ecological stability where the effects of climate change were mitigated. The chronological framework of the vegetation record, spanning the Last Interglacial-Glacial cycle, was established by (i) AMS 14C dating, (ii) correlation with well-dated pollen sequences, and (iii) local stratigraphical constraints. A high lithological and sedimentological variability, with facies associations changing from fluvial to alluvial and coastal plain, enhances the palaeoenvironmental control on pollen distribution, thus helping to discriminate the impact of local factors on vegetation history. The most remarkable evidence, however, is represented by the continuous record of temperate trees throughout the whole glacial period, which provides useful indications on the location and nature of cold stage refugia. Most of the vegetation changes recorded in the core can be compared to the vegetation history of the Last Interglacial-Glacial cycle from southern Europe as a whole. In addition, local geographic and environmental features account for a more complex and varied floristic composition. Only the last phase of the Penultimate Glacial (MIS6), which was characterized by the diffusion of an arid steppe tundra, is recorded at the base of the core. The subsequent Last Interglacial (MIS5e) interval shows a poor and scattered pollen content due to the instability of the sedimentary environment. Nevertheless, it provides evidence of both global and local controls on vegetation dynamics, as indicated by the initial expansion of thermophilous forests and the remarkably late diffusion of conifers ( Pinus-Abies-Picea forests), respectively. Similarly, the transition to the Last Glacial (MIS5b and 5a in the core) is characterized by a reduced vegetation response to the typical stadial/interstadial climate variability. This is because the diffusion of a characteristic pioneer vegetation (mainly represented by Hippophae cf. rhamnoides) helped to confer to the local environment a high ecological stability, buffering vegetation changes. Finally, during the Last Glacial, mixed broad-leaved deciduous and Pinus forests widely occupied the Arno coastal plain, demonstrating that this area acted as an important tree refuge. Local ecological conditions favourable to tree survival were determined mainly by (i) high precipitation, as a function of orographic uplift of air charged with moisture from the nearby Tyrrhenian Sea, (ii) mild temperatures, which were also influenced by proximity to the sea, and (iii) high topographic variability, providing a series of suitable microenvironments.

Highly variable recurrence of tsunamis in the 7,400 years before the 2004 Indian Ocean tsunami

NASA Astrophysics Data System (ADS)

Horton, B.; Rubin, C. M.; Sieh, K.; Jessica, P.; Daly, P.; Ismail, N.; Parnell, A. C.

2017-12-01

The devastating 2004 Indian Ocean tsunami caught millions of coastal residents and the scientific community off-guard. Subsequent research in the Indian Ocean basin has identified prehistoric tsunamis, but the timing and recurrence intervals of such events are uncertain. Here, we identify coastal caves as a new depositional environment for reconstructing tsunami records and present a 5,000 year record of continuous tsunami deposits from a coastal cave in Sumatra, Indonesia which shows the irregular recurrence of 11 tsunamis between 7,400 and 2,900 years BP. The data demonstrates that the 2004 tsunami was just the latest in a sequence of devastating tsunamis stretching back to at least the early Holocene and suggests a high likelihood for future tsunamis in the Indian Ocean. The sedimentary record in the cave shows that ruptures of the Sunda megathrust vary between large (which generated the 2004 Indian Ocean tsunami) and smaller slip failures. The chronology of events suggests the recurrence of multiple smaller tsunamis within relatively short time periods, interrupted by long periods of strain accumulation followed by giant tsunamis. The average time period between tsunamis is about 450 years with intervals ranging from a long, dormant period of over 2,000 years, to multiple tsunamis within the span of a century. The very long dormant period suggests that the Sunda megathrust is capable of accumulating large slip deficits between earthquakes. Such a high slip rupture would produce a substantially larger earthquake than the 2004 event. Although there is evidence that the likelihood of another tsunamigenic earthquake in Aceh province is high, these variable recurrence intervals suggest that long dormant periods may follow Sunda Megathrust ruptures as large as that of 2004 Indian Ocean tsunami. The remarkable variability of recurrence suggests that regional hazard mitigation plans should be based upon the high likelihood of future destructive tsunami demonstrated by the cave record and other paleotsunami sites, rather than estimates of recurrence intervals.

Genome Data Exploration Using Correspondence Analysis

PubMed Central

Tekaia, Fredj

2016-01-01

Recent developments of sequencing technologies that allow the production of massive amounts of genomic and genotyping data have highlighted the need for synthetic data representation and pattern recognition methods that can mine and help discovering biologically meaningful knowledge included in such large data sets. Correspondence analysis (CA) is an exploratory descriptive method designed to analyze two-way data tables, including some measure of association between rows and columns. It constructs linear combinations of variables, known as factors. CA has been used for decades to study high-dimensional data, and remarkable inferences from large data tables were obtained by reducing the dimensionality to a few orthogonal factors that correspond to the largest amount of variability in the data. Herein, I review CA and highlight its use by considering examples in handling high-dimensional data that can be constructed from genomic and genetic studies. Examples in amino acid compositions of large sets of species (viruses, phages, yeast, and fungi) as well as an example related to pairwise shared orthologs in a set of yeast and fungal species, as obtained from their proteome comparisons, are considered. For the first time, results show striking segregations between yeasts and fungi as well as between viruses and phages. Distributions obtained from shared orthologs show clusters of yeast and fungal species corresponding to their phylogenetic relationships. A direct comparison with the principal component analysis method is discussed using a recently published example of genotyping data related to newly discovered traces of an ancient hominid that was compared to modern human populations in the search for ancestral similarities. CA offers more detailed results highlighting links between modern humans and the ancient hominid and their characterizations. Compared to the popular principal component analysis method, CA allows easier and more effective interpretation of results, particularly by the ability of relating individual patterns with their corresponding characteristic variables. PMID:27279736

Mechanical Mixing and Metamorphism of Mafic and Ultramafic Lithologies during Mylonisis at the ST. Paul Transform System, Mid-Atlantic Ridge

NASA Astrophysics Data System (ADS)

Adrião, Á.; Maia, M.; Hemond, C.; Kaczmarek, M. A.; Briais, A.; Vincent, C.; Brunelli, D.

2017-12-01

The St. Paul Transform System offsets by 630 km the Equatorial Mid Atlantic Ridge at 1° N. It consists of four major faults separating three intra transform ridge axes. This region shows a transition from a transpressive, hot spot affected, regional-scale shear zone to the North to a region dominated by a particular oceanic core complex spreading to the South (Vincent et al., this congress). Samples collected in the region during the COLMEIA cruise (Maia et al., 2016) were studied for textures and whole-rock major and trace element contents. All samples experienced pervasive deformation at ductile to brittle conditions overprinted by late low-T alteration. Mylonitic and ultramylonitic rocks can be grouped in three main types: peridotitic, gabbroic and talc-chlorite schist. Peridotitic ultramylonites preserve few opx, cpx and sp porphyroclasts; they have homogeneous nano-micro grain size groundmass, banded foliation and late amphibole and sulfide crystallization. Locally S-C fabric overprints the mylonitic texture. Micro cracks, filled with serpentine, chlorite and oxides are common, as well fluid inclusions trails in olivine and plagioclase crystals of peridotite and gabbros respectively. Major and trace element content of the peridotitic mylonites plot in the depleted field of the abyssal peridotites; however, they present marked LREE enrichment and Eu positive anomaly. Gabbroic and talc-chlorite mylonites display REE-enriched patterns (up to 100x CI) and variable Eu anomalies. Major elements show a remarkable linear trend in the talc-chlorite group suggesting mixing of pure talc and chlorite end-members. These compositional characteristics suggest variable assimilation of MORB and E-MORB during mylonisis or early melt-rock interaction and hydrothermal evolution at variable metamorphic conditions. Vincent et al., 2017. Particular Oceanic Core Complex evolution …; this congress Maia et al., 2016. Extreme mantle uplift and exhumation ... Nat. Geo. doi:10.1038/ngeo2759

PG0027 + 260 - An example of a class of cataclysmic binaries with mysterious, but consistent, behavior

NASA Technical Reports Server (NTRS)

Thorstensen, John R.; Ringwald, F. A.; Wade, Richard A.; Schmidt, Gary D.; Norsworthy, Jane E.

1991-01-01

This paper reports extensive optical observations on the PG0027 + 260 binary, carried out on August 1984 with the 1.3 McGraw-Hill telescope and Mark II spectrometer at Michigan-Dartmouth-MIT Observatory on Kitt Peak. It is shown that this object is an eclipsing novalike variable with an orbital period of 3.51 hr. The PG0027 + 260 displays several unexplained phenomena which are remarkably similar to those of the SW Sex, DW UMa, and V1315 Aql, which are eclipsing novalike stars with periods between 3 and 4 hrs. The eclipse of the PG0027 + 260 is modeled, and it is shown that, while the mean eclipse light curve is easy to match, there is no simple explanation for the variable depth.

Complete mitochondrial genome of Yangtze River wild common carp (Cyprinus carpio haematopterus) and Russian scattered scale mirror carp (Cyprinus carpio carpio).

PubMed

Hu, Guang Fu; Liu, Xiang Jiang; Zou, Gui Wei; Li, Zhong; Liang, Hong-Wei; Hu, Shao-Na

2016-01-01

We sequenced the complete mitogenomes of (Cyprinus carpio haematopterus) and Russian scattered scale mirror carp (Cyprinus carpio carpio). Comparison of these two mitogenomes revealed that the mitogenomes of these two common carp strains were remarkably similar in genome length, gene order and content, and AT content. There were only 55 bp variations in 16,581 nucleotides. About 1 bp variation was located in rRNAs, 2 bp in tRNAs, 9 bp in the control region and 43 bp in protein-coding genes. Furthermore, forty-three variable nucleotides in the protein-coding genes of the two strains led to four variable amino acids, which were located in the ND2, ATPase 6, ND5 and ND6 genes, respectively.

Modeling the influence of atmospheric leading modes on the variability of the Arctic freshwater cycle

NASA Astrophysics Data System (ADS)

Niederdrenk, L.; Sein, D.; Mikolajewicz, U.

2013-12-01

Global general circulation models show remarkable differences in modeling the Arctic freshwater cycle. While they agree on the general sinks and sources of the freshwater budget, they differ largely in the magnitude of the mean values as well as in the variability of the freshwater terms. Regional models can better resolve the complex topography and small scale processes, but they are often uncoupled, thus missing the air-sea interaction. Additionally, regional models mostly use some kind of salinity restoring or flux correction, thus disturbing the freshwater budget. Our approach to investigate the Arctic hydrologic cycle and its variability is a regional atmosphere-ocean model setup, consisting of the global ocean model MPIOM with high resolution in the Arctic coupled to the regional atmosphere model REMO. The domain of the atmosphere model covers all catchment areas of the rivers draining into the Arctic. To account for all sinks and sources of freshwater in the Arctic, we include a discharge model providing terrestrial lateral waterflows. We run the model without salinity restoring but with freshwater correction, which is set to zero in the Arctic. This allows for the analysis of a closed freshwater budget in the Artic region. We perform experiments for the second half of the 20th century and use data from the global model MPIOM/ECHAM5 performed with historical conditions, that was used within the 4th Assessment Report of the IPCC, as forcing for our regional model. With this setup, we investigate how the dominant modes of large-scale atmospheric variability impact the variability in the freshwater components. We focus on the two leading empirical orthogonal functions of winter mean sea level pressure, as well as on the North Atlantic Oscillation and the Siberian High. These modes have a large impact on the Arctic Ocean circulation as well as on the solid and liquid export through Fram Strait and through the Canadian archipelago. However, they cannot explain the variability in river runoff. We find that not only winter conditions are responsible for increased river runoff, but also an enhanced summer cyclone activity, especially over Eurasia.

Olivine-hosted melt inclusions record efficient mixing of mantle melts in continental flood basalt provinces

NASA Astrophysics Data System (ADS)

Jennings, E. S.; Gibson, S. A.; Maclennan, J.; Heinonen, J. S.

2017-12-01

Primitive melt inclusions trapped in various minerals found in global ridge settings have been shown to record highly variable magmatic compositions. Mantle melting is expected to be near-fractional, producing a wide range of melt compositions that must accumulate and mix in crustal magma chambers. In primitive rocks, the melt inclusion variability observed in major, trace and isotope geochemistry is consistent to the first order with partial melting of variably depleted mantle, and indicate that the host phases began to crystallise prior to the completion of melt aggregation and mixing. We present new major and trace element data from a large number of rehomogenised olivine-hosted melt inclusions from the Cretaceous Paraná-Etendeka and Jurassic Karoo continental flood basalt (CFB) provinces [1]. We show that the major element chemistry of the melt inclusions can be severely disrupted by the rehomogenisation process and, as a consequence, their initial compositions cannot easily be back-calculated. However, despite the age of the samples, the trace element geochemistry of the melt inclusions is well-preserved. Despite coming from near-liquidus olivines from primitive picrites and ferropicrites, the inclusions are remarkably homogeneous; none of the anticipated variability in incompatible trace element compositions is observed. When considered alongside literature data, it appears that variability in primitive melts - as recorded by melt inclusions - is low in CFBs and OIBs relative to ridge settings, e.g. Iceland. We suggest that the tectonic setting imposes a control on the mixing of mantle melts: hot, plume-derived melts generated beneath relatively thick lithosphere may be prone to efficient mixing, perhaps due to their low viscosity, long transport pathways, and/or a superliquidus emplacement temperature [1]. This interpretation is supported by the almost non-existent variability of olivine-hosted inclusions from ferropicrite samples: these magmas represents the deepest, hottest and lowest viscosity magma of all the samples considered. [1] Jennings E. S., Gibson S. A., Maclennan J. and Heinonen J. S. (2017) Deep mixing of mantle melts beneath continental flood basalt provinces: Constraints from olivine-hosted melt inclusions in primitive magmas. Geochimica et Cosmochimica Acta 196, 36-57.

The Remarkable Change in Euro-American Cranial Shape and Size.

PubMed

Jantz, Richard L; Jantz, Lee Meadows

2016-01-01

Secular changes in stature, weight, or other components of the body that can be obtained from historical records have been extensively studied. Cranial change has been central to anthropology for more than a century, but the focus has normally been on change measured in centuries or millennia. Cranial change measured in decades, normally considered to result from plastic response to the environment, has been less studied. This article reports on change in cranial vault dimensions in white Americans. Variables were glabello-occipital length (GOL), basion-bregma height (BBH), basion-nasion length (BNL), maximum cranial breadth (XCB), and biauricular breadth (AUB). Cranial size was calculated as the geometric mean of these variables, and shape dimensions were calculated as described by Darroch and Mosimann ( 1985 ). Cranial module and cranial capacity were also calculated. Samples consisted of 1,112 males and 668 females complete for those variables. Samples were organized into 10-year birth cohorts, with birth years ranging from 1820 to 1990. One-way ANOVA was used to test for variation among cohorts. The pattern of secular change was examined graphically and was compared with quality-of-life and environmental indicators, including stature, infant mortality, calories per person, and relative number of immigrants. All variables showed significant secular change, but BBH, XCB, and BNL responded most strongly. Over the past 170 years, crania became relatively higher, narrower, and larger with longer cranial bases. Both sexes changed, but female change was less pronounced than male change. The cranial variables tracked secular changes in stature, most prominently BNL. The highest correlation between a cranial variable and quality-of-life indicator was BBH and infant mortality. We are not able to identify specific causes of secular changes in cranial morphology. However, given that modern Americans have introduced themselves into a novel environment never before experienced by human populations, we consider it unlikely that it is pure plasticity. In addition to possible plastic responses, it is likely that selection, acting through the dramatic changes in infant mortality, is also involved.

Delta Scuti Variables

NASA Astrophysics Data System (ADS)

Handler, Gerald

2009-09-01

We review recent research on Delta Scuti stars from an observer's viewpoint. First, some signposts helping to find the way through the Delta Scuti jungle are placed. Then, some problems in studying individual pulsators in the framework of asteroseismology are given before a view on how the study of these variables has benefited (or not) from past and present high-precision asteroseismic space missions is presented. Some possible pitfalls in the analysis of data with a large dynamical range in pulsational amplitudes are pointed out, and a strategy to optimize the outcome of asteroseismic studies of Delta Scuti stars is suggested. We continue with some views on ``hybrid'' pulsators and interesting individual High Amplitude Delta Scuti stars, and then take a look on Delta Scuti stars in stellar systems of several different kinds. Recent results on pre-main sequence Delta Scuti stars are discussed as are questions related to the instability strip of these variables. Finally, some remarkable new theoretical results are highlighted before, instead of a set of classical conclusions, questions to be solved in the future, are raised.

Climatology of extreme daily precipitation in Colorado and its diverse spatial and seasonal variability

USGS Publications Warehouse

Mahoney, Kelly M.; Ralph, F. Martin; Walter, Klaus; Doesken, Nolan; Dettinger, Michael; Gottas, Daniel; Coleman, Timothy; White, Allen

2015-01-01

The climatology of Colorado’s historical extreme precipitation events shows a remarkable degree of seasonal and regional variability. Analysis of the largest historical daily precipitation totals at COOP stations across Colorado by season indicates that the largest recorded daily precipitation totals have ranged from less than 60 mm day−1 in some areas to more than 250 mm day−1 in others. East of the Continental Divide, winter events are rarely among the top 10 events at a given site, but spring events dominate in and near the foothills; summer events are most common across the lower-elevation eastern plains, while fall events are most typical for the lower elevations west of the Divide. The seasonal signal in Colorado’s central mountains is complex; high-elevation intense precipitation events have occurred in all months of the year, including summer, when precipitation is more likely to be liquid (as opposed to snow), which poses more of an instantaneous flood risk. Notably, the historic Colorado Front Range daily rainfall totals that contributed to the damaging floods in September 2013 occurred outside of that region’s typical season for most extreme precipitation (spring–summer). That event and many others highlight the fact that extreme precipitation in Colorado has occurred historically during all seasons and at all elevations, emphasizing a year-round statewide risk.

Remarkable sequence conservation of the last intron in the PKD1 gene.

PubMed

Rodova, Marianna; Islam, M Rafiq; Peterson, Kenneth R; Calvet, James P

2003-10-01

The last intron of the PKD1 gene (intron 45) was found to have exceptionally high sequence conservation across four mammalian species: human, mouse, rat, and dog. This conservation did not extend to the comparable intron in pufferfish. Pairwise comparisons for intron 45 showed 91% identity (human vs. dog) to 100% identity (mouse vs. rat) for an average for all four species of 94% identity. In contrast, introns 43 and 44 of the PKD1 gene had average pairwise identities of 57% and 54%, and exons 43, 44, and 45 and the coding region of exon 46 had average pairwise identities of 80%, 84%, 82%, and 80%. Intron 45 is 90 to 95 bp in length, with the major region of sequence divergence being in a central 4-bp to 9-bp variable region. RNA secondary structure analysis of intron 45 predicts a branching stem-loop structure in which the central variable region lies in one loop and the putative branch point sequence lies in another loop, suggesting that the intron adopts a specific stem-loop structure that may be important for its removal. Although intron 45 appears to conform to the class of small, G-triplet-containing introns that are spliced by a mechanism utilizing intron definition, its high sequence conservation may be a reflection of constraints imposed by a unique mechanism that coordinates splicing of this last PKD1 intron with polyadenylation.

Technical efficiency of teaching hospitals in Iran: the use of Stochastic Frontier Analysis, 1999–2011

PubMed Central

Goudarzi, Reza; Pourreza, Abolghasem; Shokoohi, Mostafa; Askari, Roohollah; Mahdavi, Mahdi; Moghri, Javad

2014-01-01

Background: Hospitals are highly resource-dependent settings, which spend a large proportion of healthcare financial resources. The analysis of hospital efficiency can provide insight into how scarce resources are used to create health values. This study examines the Technical Efficiency (TE) of 12 teaching hospitals affiliated with Tehran University of Medical Sciences (TUMS) between 1999 and 2011. Methods: The Stochastic Frontier Analysis (SFA) method was applied to estimate the efficiency of TUMS hospitals. A best function, referred to as output and input parameters, was calculated for the hospitals. Number of medical doctors, nurses, and other personnel, active beds, and outpatient admissions were considered as the input variables and number of inpatient admissions as an output variable. Results: The mean level of TE was 59% (ranging from 22 to 81%). During the study period the efficiency increased from 61 to 71%. Outpatient admission, other personnel and medical doctors significantly and positively affected the production (P< 0.05). Concerning the Constant Return to Scale (CRS), an optimal production scale was found, implying that the productions of the hospitals were approximately constant. Conclusion: Findings of this study show a remarkable waste of resources in the TUMS hospital during the decade considered. This warrants policy-makers and top management in TUMS to consider steps to improve the financial management of the university hospitals. PMID:25114947

Seasonal modulation of the Asian summer monsoon between the Medieval Warm Period and Little Ice Age: a multi model study

NASA Astrophysics Data System (ADS)

Kamae, Youichi; Kawana, Toshi; Oshiro, Megumi; Ueda, Hiroaki

2017-12-01

Instrumental and proxy records indicate remarkable global climate variability over the last millennium, influenced by solar irradiance, Earth's orbital parameters, volcanic eruptions and human activities. Numerical model simulations and proxy data suggest an enhanced Asian summer monsoon during the Medieval Warm Period (MWP) compared to the Little Ice Age (LIA). Using multiple climate model simulations, we show that anomalous seasonal insolation over the Northern Hemisphere due to a long cycle of orbital parameters results in a modulation of the Asian summer monsoon transition between the MWP and LIA. Ten climate model simulations prescribing historical radiative forcing that includes orbital parameters consistently reproduce an enhanced MWP Asian monsoon in late summer and a weakened monsoon in early summer. Weakened, then enhanced Northern Hemisphere insolation before and after June leads to a seasonally asymmetric temperature response over the Eurasian continent, resulting in a seasonal reversal of the signs of MWP-LIA anomalies in land-sea thermal contrast, atmospheric circulation, and rainfall from early to late summer. This seasonal asymmetry in monsoon response is consistently found among the different climate models and is reproduced by an idealized model simulation forced solely by orbital parameters. The results of this study indicate that slow variation in the Earth's orbital parameters contributes to centennial variability in the Asian monsoon transition.[Figure not available: see fulltext.

Assessment of intrafamilial clinical variability of poikiloderma with neutropenia by a 10-year follow-up of three affected siblings.

PubMed

Concolino, Daniela; Sestito, Simona; Falvo, Francesca; Romano, Giusy; Ceravolo, Miriam; Anastasio, Elisa; Pensabene, Licia; Colombo, Elisa A; Larizza, Lidia

2018-05-23

Clericuzio-type poikiloderma with neutropenia is a well-defined nosological entity, but despite a remarkable number of clinical reports, no long term follow-up data has been presented to date regarding patients with this rare condition. Here we describe the results of clinical follow-up of three siblings, one male (Patient 1) and two females (Patients 2 and 3), subsequent to their first clinical and then molecular diagnosis of Clericuzio-type poikiloderma with neutropenia syndrome due to mutation of USB1gene. Patient 1 always expressed the most severe phenotype, while patients 2 and 3 showed an intermediate and mild phenotype, respectively, as observed since their first clinical evaluation. None of the patients developed skin cancer and/or myelodysplastic disorders considering the peripheral haematological findings. Lens opacity, never reported before, was found in two of the three patients. The long term follow-up observations confirm the stability over time of the pronounced intra-familial heterogeneity of clinical manifestations observed prior to and upon molecular diagnosis. We conclude that prolonged follow-up is an adjunct tool to monitor intra-familial variability of PN clinical spectrum which may favour surveillance of more serious complications of the disease among siblings, when a patient-specific clinical expressivity is present. Copyright © 2018. Published by Elsevier Masson SAS.

Temporal-spatial characteristics of severe drought events in Southwest China and their relationships to teleconnection indices

NASA Astrophysics Data System (ADS)

Wang, P., III; Wu, C.; Hao, Y.; Xu, K.

2017-12-01

In the process of global warming, the frequency and intensity of a series of climate events (such as, precipitation, flood disaster, climate arid) are also being changed. Even in the today of advanced science and technology, the occurrence and severity of drought in China is still devastating impact on social and economic development. We studied the spatial and temporal variability of drought in southwestern China China and its relationships to teleconnection indices. We used the Palmer Drought Severity Index (PDSI) to investigate the variation in drought in southwestern China between 1961 and 2012 using the Mann-Kendall (MK), continuous wavelet transform (CWT) and the rotated empirical orthogonal function (REOF) methods. Additionally, We analyzed the relationships between the time variability of significant patterns and teleconnection indices. The PDSI shows that there is a trend of turning dry in west Tibet; while it is remarkably drying in junction of Yunnan, Guizhou, Sichuan, Chongqing provinces, and the drought in Spring is more severe than in autumn, with a changing oscillation period of 2-7a. It's found the drought strength reducing before rising without a obvious turning point. Also, the drought frequency staggered in spatial distribution, and a larger inter-annual difference. AO and SS are the most important factors among all the drought influence factors, the others differ from the importance.

Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery

PubMed Central

Voss, Patrice; Thomas, Maryse E.; Cisneros-Franco, J. Miguel; de Villers-Sidani, Étienne

2017-01-01

A growing number of research publications have illustrated the remarkable ability of the brain to reorganize itself in response to various sensory experiences. A traditional view of this plastic nature of the brain is that it is predominantly limited to short epochs during early development. Although examples showing that neuroplasticity exists outside of these finite time-windows have existed for some time, it is only recently that we have started to develop a fuller understanding of the different regulators that modulate and underlie plasticity. In this article, we will provide several lines of evidence indicating that mechanisms of neuroplasticity are extremely variable across individuals and throughout the lifetime. This variability is attributable to several factors including inhibitory network function, neuromodulator systems, age, sex, brain disease, and psychological traits. We will also provide evidence of how neuroplasticity can be manipulated in both the healthy and diseased brain, including recent data in both young and aged rats demonstrating how plasticity within auditory cortex can be manipulated pharmacologically and by varying the quality of sensory inputs. We propose that a better understanding of the individual differences that exist within the various mechanisms that govern experience-dependent neuroplasticity will improve our ability to harness brain plasticity for the development of personalized translational strategies for learning and recovery following brain injury or disease. PMID:29085312

Magic angle spinning NMR below 6 K with a computational fluid dynamics analysis of fluid flow and temperature gradients

NASA Astrophysics Data System (ADS)

Sesti, Erika L.; Alaniva, Nicholas; Rand, Peter W.; Choi, Eric J.; Albert, Brice J.; Saliba, Edward P.; Scott, Faith J.; Barnes, Alexander B.

2018-01-01

We report magic angle spinning (MAS) up to 8.5 kHz with a sample temperature below 6 K using liquid helium as a variable temperature fluid. Cross polarization 13C NMR spectra exhibit exquisite sensitivity with a single transient. Remarkably, 1H saturation recovery experiments show a 1H T1 of 21 s with MAS below 6 K in the presence of trityl radicals in a glassy matrix. Leveraging the thermal spin polarization available at 4.2 K versus 298 K should result in 71 times higher signal intensity. Taking the 1H longitudinal relaxation into account, signal averaging times are therefore predicted to be expedited by a factor of >500. Computer assisted design (CAD) and finite element analysis were employed in both the design and diagnostic stages of this cryogenic MAS technology development. Computational fluid dynamics (CFD) models describing temperature gradients and fluid flow are presented. The CFD models bearing and drive gas maintained at 100 K, while a colder helium variable temperature fluid stream cools the center of a zirconia rotor. Results from the CFD were used to optimize the helium exhaust path and determine the sample temperature. This novel cryogenic experimental platform will be integrated with pulsed dynamic nuclear polarization and electron decoupling to interrogate biomolecular structure within intact human cells.

Zipf 's law and the effect of ranking on probability distributions

NASA Astrophysics Data System (ADS)

Günther, R.; Levitin, L.; Schapiro, B.; Wagner, P.

1996-02-01

Ranking procedures are widely used in the description of many different types of complex systems. Zipf's law is one of the most remarkable frequency-rank relationships and has been observed independently in physics, linguistics, biology, demography, etc. We show that ranking plays a crucial role in making it possible to detect empirical relationships in systems that exist in one realization only, even when the statistical ensemble to which the systems belong has a very broad probability distribution. Analytical results and numerical simulations are presented which clarify the relations between the probability distributions and the behavior of expected values for unranked and ranked random variables. This analysis is performed, in particular, for the evolutionary model presented in our previous papers which leads to Zipf's law and reveals the underlying mechanism of this phenomenon in terms of a system with interdependent and interacting components as opposed to the “ideal gas” models suggested by previous researchers. The ranking procedure applied to this model leads to a new, unexpected phenomenon: a characteristic “staircase” behavior of the mean values of the ranked variables (ranked occupation numbers). This result is due to the broadness of the probability distributions for the occupation numbers and does not follow from the “ideal gas” model. Thus, it provides an opportunity, by comparison with empirical data, to obtain evidence as to which model relates to reality.

Individual differences in perceptual adaptability of foreign sound categories

PubMed Central

Schertz, Jessamyn; Cho, Taehong; Lotto, Andrew; Warner, Natasha

2015-01-01

Listeners possess a remarkable ability to adapt to acoustic variability in the realization of speech sound categories (e.g. different accents). The current work tests whether non-native listeners adapt their use of acoustic cues in phonetic categorization when they are confronted with changes in the distribution of cues in the input, as native listeners do, and examines to what extent these adaptation patterns are influenced by individual cue-weighting strategies. In line with previous work, native English listeners, who use VOT as a primary cue to the stop voicing contrast (e.g. ‘pa’ vs. ‘ba’), adjusted their use of f0 (a secondary cue to the contrast) when confronted with a noncanonical “accent” in which the two cues gave conflicting information about category membership. Native Korean listeners’ adaptation strategies, while variable, were predictable based on their initial cue weighting strategies. In particular, listeners who used f0 as the primary cue to category membership adjusted their use of VOT (their secondary cue) in response to the noncanonical accent, mirroring the native pattern of “downweighting” a secondary cue. Results suggest that non-native listeners show native-like sensitivity to distributional information in the input and use this information to adjust categorization, just as native listeners do, with the specific trajectory of category adaptation governed by initial cue-weighting strategies. PMID:26404530

Mucus-penetrating solid lipid nanoparticles for the treatment of cystic fibrosis: Proof of concept, challenges and pitfalls.

PubMed

Nafee, N; Forier, K; Braeckmans, K; Schneider, M

2018-03-01

Nanocarrier-mediated transmucosal drug delivery based on conventional mucoadhesive, muco-inert or mucus-penetrating nanoparticles (NPs) is a growing field especially in challenging diseases like cystic fibrosis (CF). Efficacy of such systems dictates profound investigation of particle-mucus interaction and factors governing the whole process. Although variable techniques studying particle diffusion in mucus have been introduced, standardized procedures are lacking. The study comprised different methods based on micro- and macro-displacement as well as colloidal stability and turbidimetric experiments. Artificial sputum medium (ASM), CF sputum and mucus-secreting cell line (Calu-3 air interface culture, AIC) were applied. Solid lipid nanoparticles (SLNs) coated with variable hydrophilic sheath (poloxamer, Tween 80 or PVA) represented the nanocarriers under investigation. Both micro-displacement studies based on single particle tracking and macro-displacement experiments based on 3D-time laps confocal imaging revealed faster diffusion of poloxamer- > Tween- > PVA-coated SLNs. Compared to ASM, CF sputum showed not only lower diffusion rates but also remarkable discrepancies in particle-mucus diffusion rate due to sputum heterogenicity. Meanwhile, in case of Calu-3 AIC, thickness of the mucosal layer as well as density of mucus network were key determinants in the diffusion process. The points emphasized in this study highlight the road towards in vivo relevant particle-mucus interaction research. Copyright © 2018 Elsevier B.V. All rights reserved.

A new strategy for umbilical cord blood collection developed at the first Colombian public cord blood bank increases total nucleated cell content.

PubMed

Vanegas, Diana; Triviño, Lady; Galindo, Cristian; Franco, Leidy; Salguero, Gustavo; Camacho, Bernardo; Perdomo-Arciniegas, Ana-María

2017-09-01

The total nucleated cell dosage of umbilical cord blood (UCB) is an important factor in determining successful allogeneic hematopoietic stem cell transplantation after a minimum human leukocyte antigen donor-recipient match. The northern South American population is in need of a new-generation cord blood bank that cryopreserves only units with high total nucleated cell content, thereby increasing the likelihood of use. Colombia set up a public cord blood bank in 2014; and, as a result of its research for improving high total nucleated cell content, a new strategy for UCB collection was developed. Data from 2933 collected and 759 cryopreserved cord blood units between 2014 and 2015 were analyzed. The correlation of donor and collection variables with cellularity was evaluated. Moreover, blood volume, cell content, CD34+ count, clonogenic capacity, and microbial contamination were assessed comparing the new method, which combines in utero and ex utero techniques, with the conventional strategies. Multivariate analysis confirmed a correlation between neonatal birth weight and cell content. The new collection method increased total nucleated cell content in approximately 26% and did not alter pre-cryopreservation and post-thaw cell recovery, viability, or clonogenic ability. Furthermore, it showed a remarkably low microbial contamination rate (1.2%). The strategy for UCB collection developed at the first Colombian public cord blood bank increases total nucleated cell content and does not affect unit quality. The existence of this bank is a remarkable breakthrough for Latin-American patients in need of this kind of transplantation. © 2017 The Authors Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.

Remarkable Variation in the Informativeness of RFLP Markers Linked to Hemophilia B Locus in Indian Population Groups: Implication in the Strategy for Carrier Detection

PubMed Central

Mukherjee, S.; Saha, A.; Kumar P., Senthil; Chandak, G. R.; Majumder, P. P.; Ray, K.

2006-01-01

Hemophilia B, an X-linked recessive bleeding disorder, is caused by heterogeneous mutations in the factor IX (F9) gene. Hence, carriers of the disease are usually detected by F9 gene linked RFLP analysis. We aimed to test a set of RFLP markers (DdeI, XmnI, MnlI, TaqI & HhaI), used worldwide for carrier detection, to estimate its heterozygosity in different population groups of India, and identify additional single nucleotide polymorphisms (SNPs) if necessary. A total of 8 population groups encompassing different regions of India, consisting of 107 unrelated normal females without any history of hemophilia B in the family and 13 unrelated obligate carriers were recruited in the study. Regions of F9 gene were amplified by PCR from genomic DNA of the donors followed by restriction enzyme digestion and/or sequencing as appropriate. Combined informativeness for the markers varied between 52–86% among normal females belonging to different geographical locations of India. Haplotype analysis revealed that the most prevalent haplotype lacked the restriction sites for all five RFLP markers. Screening regions of F9 gene that harbor 10 SNPs reported in dbSNP yielded only two SNPs, which increased the overall informativeness in each population group and heterozygosity in the obligate carriers for the disease from 38% to 69%. Our data show that heterozygosity of commonly used RFLP markers is remarkably variable across different regions of India. Thus prudent selection of the markers based on specific population groups including usage of additional markers is recommended for efficient carrier detection. PMID:17264403

Biosurfactants and surfactants interacting with membranes and proteins: Same but different?

PubMed

Otzen, Daniel E

2017-04-01

Biosurfactants (BS) are surface-active molecules produced by microorganisms. For several decades they have attracted interest as promising alternatives to current petroleum-based surfactants. Aside from their green profile, they have remarkably low critical micelle concentrations, reduce the air/water surface tension to very low levels and are excellent emulsifiers, all of which make them comparable or superior to their synthetic counterparts. These remarkable physical properties derive from their more complex chemical structures in which hydrophilic and hydrophobic regions are not as clearly separated as chemical surfactants but have a more mosaic distribution of polarity as well as branched or circular structures. This allows the lipopeptide surfactin to adopt spherical structures to facilitate dense packing at interfaces. They are also more complex. Glycolipid BS, e.g. rhamnolipids (RL) and sophorolipids, are produced biologically as mixtures which vary in the size and saturation of the hydrophobic region as well as modifications in the hydrophilic headgroup, such as the number of sugar groups and different levels of acetylation, leading to variable surface-active properties. Their amphiphilicity allows RL to insert easily into membranes at sub-cmc concentrations to modulate membrane structure and extract lipopolysaccharides, leading to extensive biofilm remodeling in vivo, sometimes in collaboration with hydrophobic RL precursors. Thanks to their mosaicity, even anionic BS like RL only bind weakly to proteins and show much lower denaturing potency, even supporting membrane protein refolding. Nevertheless, they can promote protein degradation by proteases e.g. by neutralizing positive charges, which together with their biofilm-combating properties makes them very promising detergent surfactants. This article is part of a Special Issue entitled: Lipid order/lipid defects and lipid-control of protein activity edited by Dirk Schneider. Copyright © 2016 Elsevier B.V. All rights reserved.

Benjamin P. Flower (1962-2012)

NASA Astrophysics Data System (ADS)

Hastings, David W.; Shevenell, Amelia E.; Kennett, James P.

2012-10-01

Benjamin P. Flower, a gifted paleoceanographer and marine geologist, supportive colleague, and dedicated educator at the University of South Florida (USF) College of Marine Science (CMS) passed away on 1 July 2012 from complications related to a rare genetic immune dysfunction, Common Variable Immunodeficiency. He was 49 years old. During his brief illness, Ben's love of life and boundless high spirits were an inspiration to his family, friends, and colleagues. He exhibited remarkable courage and kept his sense of humor in face of adversity. Ben's intellectualism and enduring love of science remained intact, even in his last hours.

Atlantic salmon (Salmo salar) smolt production: the relative importance of survival and body growth

USGS Publications Warehouse

Horton, G.E.; Letcher, B.H.; Bailey, M.M.; Kinnison, M.T.

2009-01-01

The complex life history of Atlantic salmon (Salmo salar) coupled with interacting abiotic and biotic factors leads to extreme demographic variability across the species' range. Our goal was to evaluate the relative importance of survival and body growth in determining smolt production across space and time. We used passive integrated transponder tags and capture-mark-recapture analyses to estimate survival, emigration, and growth for six cohorts of presmolt Atlantic salmon in two streams (three cohorts per stream) in New England, USA. We observed remarkable among-cohort consistency in mean monthly survival during a 17-month period from age-0+ autumn to age-2+ spring yet high variability in monthly survival over shorter time intervals (seasons). Despite this latter variability, survival did not translate into amongcohort differences in proportions of age-2+ versus age-3+ smolts. Alternatively, the high variability across seasons and cohorts in mean individual growth rate did lead to differences in within-cohort proportions of age-2+ versus age-3+ smolts (regardless of stream). We conclude that in our two small study streams, variability in growth and size impacted smolt age and, ultimately, smolt production. Density-dependent effects on growth at the scale of the entire study site represent a possible mechanism underlying our observations.

Variable aperture-based ptychographical iterative engine method

NASA Astrophysics Data System (ADS)

Sun, Aihui; Kong, Yan; Meng, Xin; He, Xiaoliang; Du, Ruijun; Jiang, Zhilong; Liu, Fei; Xue, Liang; Wang, Shouyu; Liu, Cheng

2018-02-01

A variable aperture-based ptychographical iterative engine (vaPIE) is demonstrated both numerically and experimentally to reconstruct the sample phase and amplitude rapidly. By adjusting the size of a tiny aperture under the illumination of a parallel light beam to change the illumination on the sample step by step and recording the corresponding diffraction patterns sequentially, both the sample phase and amplitude can be faithfully reconstructed with a modified ptychographical iterative engine (PIE) algorithm. Since many fewer diffraction patterns are required than in common PIE and the shape, the size, and the position of the aperture need not to be known exactly, this proposed vaPIE method remarkably reduces the data acquisition time and makes PIE less dependent on the mechanical accuracy of the translation stage; therefore, the proposed technique can be potentially applied for various scientific researches.

Role of wind forcing and eddy activity in the intraseasonal variability of the barrier layer in the South China Sea

NASA Astrophysics Data System (ADS)

Liang, Zhanlin; Xie, Qiang; Zeng, Lili; Wang, Dongxiao

2018-03-01

In addition to widely discussed seasonal variability, the barrier layer (BL) of the South China Sea (SCS) also exhibits significant intraseasonal variability (ISV) and plays an important role in the upper heat and salt balances. The characteristics and mechanisms of spatiotemporal variations in the BL are investigated using an eddy-resolving ocean model OFES (OGCM For the Earth Simulator) ouput and related atmospheric and oceanic processes. The active intraseasonal BL variability in the SCS occurs mainly during the late summer/autumn and winter and exhibits remarkable differences between these two periods. The BL ISV in late summer/autumn occurs in the southern basin, while in winter, it is limited to the northwestern basin. To further discuss the evolution and driving thermodynamic mechanisms, we quantify the processes that control the variability of intraseasonal BL. Different mechanisms for the intraseasonal BL variability for these two active periods are investigated based on the case study and composite analysis. During late summer/autumn, the active BL in the southern basin is generated by advected and local freshwater, and then decays rapidly with the enhanced wind. In winter, anticyclonic eddy activity is associated with the evolution of the BL by affecting the thermocline and halocline variations, while wind stress and wind stress curl have no obvious influence on BL.

Physical activity levels of older community-dwelling adults are influenced by summer weather variables.

PubMed

Brandon, Caitlin A; Gill, Dawn P; Speechley, Mark; Gilliland, Jason; Jones, Gareth R

2009-04-01

Adequate daily physical activity (PA) is important for maintaining functional capacity and independence in older adults. However, most older adults in Canada do not engage in enough PA to sustain fitness and functional independence. Environmental influences, such as warmer daytime temperatures, may influence PA participation; however, few studies have examined the effect of summertime temperatures on PA levels in older adults. This investigation measured the influence of summertime weather variables on PA in 48 community-dwelling older adults who were randomly recruited from a local seniors' community centre. Each participant wore an accelerometer for a single 7-consecutive-day period (between 30 May and 9 August 2006) during waking hours, and completed a PA logbook to remark on major daily PA events. Local weather variables were collected from a national weather service and compared with PA counts per minute. Regression analysis revealed a curvilinear relationship between log-transformed PA and mean daily temperature (r2 = 0.025; p < 0.05). Linear mixed effects models that accounted for repeated measures nested within individuals were performed for monthly periods, meteorological variables, sex, age, and estimated maximal oxygen consumption, with PA as the dependent variable. Age and Air Quality Index remained significant variables within the model. Higher fitness levels had no effect on allowing individuals to perform more vigorous PA in warmer temperatures.

To transfer or not to transfer? Kinematics and laterality quotient predict interlimb transfer of motor learning.

PubMed

Lefumat, Hannah Z; Vercher, Jean-Louis; Miall, R Chris; Cole, Jonathan; Buloup, Frank; Bringoux, Lionel; Bourdin, Christophe; Sarlegna, Fabrice R

2015-11-01

Humans can remarkably adapt their motor behavior to novel environmental conditions, yet it remains unclear which factors enable us to transfer what we have learned with one limb to the other. Here we tested the hypothesis that interlimb transfer of sensorimotor adaptation is determined by environmental conditions but also by individual characteristics. We specifically examined the adaptation of unconstrained reaching movements to a novel Coriolis, velocity-dependent force field. Right-handed subjects sat at the center of a rotating platform and performed forward reaching movements with the upper limb toward flashed visual targets in prerotation, per-rotation (i.e., adaptation), and postrotation tests. Here only the dominant arm was used during adaptation and interlimb transfer was assessed by comparing performance of the nondominant arm before and after dominant-arm adaptation. Vision and no-vision conditions did not significantly influence interlimb transfer of trajectory adaptation, which on average was significant but limited. We uncovered a substantial heterogeneity of interlimb transfer across subjects and found that interlimb transfer can be qualitatively and quantitatively predicted for each healthy young individual. A classifier showed that in our study, interlimb transfer could be predicted based on the subject's task performance, most notably motor variability during learning, and his or her laterality quotient. Positive correlations suggested that variability of motor performance and lateralization of arm movement control facilitate interlimb transfer. We further show that these individual characteristics can predict the presence and the magnitude of interlimb transfer of left-handers. Overall, this study suggests that individual characteristics shape the way the nervous system can generalize motor learning. Copyright © 2015 the American Physiological Society.

Trends in the Sea Ice Cover Using Enhanced and Compatible AMSR-E, SSM/I and SMMR Data

NASA Technical Reports Server (NTRS)

Comiso, Josefino C.; Nishio, Fumihiko

2007-01-01

Arguably, the most remarkable manifestation of change in the polar regions is the rapid decline (of about -10 %/decade) in the Arctic perennial ice cover. Changes in the global sea ice cover, however, are more modest, being slightly positive in the Southern Hemisphere and slightly negative in the Northern Hemisphere, the significance of which has not been adequately assessed because of unknown errors in the satellite historical data. We take advantage of the recent and more accurate AMSR-E data to evaluate the true seasonal and interannual variability of the sea ice cover, assess the accuracy of historical data, and determine the real trend. Consistently derived ice concentrations from AMSR-E, SSM/I, and SMMR data were analyzed and a slight bias is observed between AMSR-E and SSM/I data mainly because of differences in resolution. Analysis of the combine SMMR, SSM/I and AMSR-E data set, with the bias corrected, shows that the trends in extent and area of sea ice in the Arctic region is -3.4 +/- 0.2 and -4.0 +/- 0.2 % per decade, respectively, while the corresponding values for the Antarctic region is 0.9 +/- 0.2 and 1.7 .+/- 0.3 % per decade. The higher resolution of the AMSR-E provides an improved determination of the location of the ice edge while the SSM/I data show an ice edge about 6 to 12 km further away from the ice pack. Although the current record of AMSR-E is less than 5 years, the data can be utilized in combination with historical data for more accurate determination of the variability and trends in the ice cover.

Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test.

PubMed

Viardot, Alexander; Huber, Peter; Puder, Jardena J; Zulewski, Henryk; Keller, Ulrich; Müller, Beat

2005-10-01

Nighttime salivary cortisol (NSC) has been suggested to be a useful diagnostic test for Cushing's syndrome (CS). In the absence of published data on its day-to-day variability, we assessed the reproducibility of NSC by repeated measurements in healthy volunteers. Its diagnostic performance was compared with 24-h urinary free cortisol (UFC) and 1 mg overnight dexamethasone suppression test in 12 patients with CS, 20 healthy volunteers, 14 referred patients in which CS was excluded or not firmly established, 16 obese patients, and 20 women in late pregnancy. NSC showed a superior reproducibility in healthy volunteers with a low day-to-day variability as reflected by an intraclass correlation coefficient of 0.78. The receiver operating characteristic curve-estimated cutoff of 6.1 nmol/liter (0.22 microg/dl) demonstrated a sensitivity and specificity of 100% (area under the receiver operating characteristic curve, 1.0; 95% confidence interval, 0.94-1.0) in the diagnosis of CS. NSC, 24-h UFC [after adjusting the local laboratory cutoff to 504 nmol/d (183 microg/d)], and the urinary cortisol/creatinine ratio showed a tendency to be superior to 1 mg dexamethasone suppression test in correctly identifying CS. In late pregnancy, the preserved diurnal variation at a higher level of salivary cortisol reduced the specificity of NSC to 75%. Based on its remarkable reproducibility, easy noninvasive nature, and at least similar diagnostic performance, NSC appears to be a preferable alternative to 24-h UFC as a first-line screening test for CS. The cutoff values of NSC, 24-h UFC, and urinary cortisol/creatinine ratio have to be carefully adjusted using assay and center-specific reference ranges of sufficiently large populations.

Reproducibility for Heart Rate Variability Analysis during 6-Min Walk Test in Patients with Heart Failure and Agreement between Devices.

PubMed

Braga, Lays Magalhães; Prado, Gustavo Faibischew; Umeda, Iracema Ioco Kikuchi; Kawauchi, Tatiana Satie; Taboada, Adriana Marques Fróes; Azevedo, Raymundo Soares; Pereira Filho, Horacio Gomes; Grupi, César José; Souza, Hayala Cristina Cavenague; Moreira, Dalmo Antônio Ribeiro; Nakagawa, Naomi Kondo

2016-01-01

Heart rate variability (HRV) analysis is a useful method to assess abnormal functioning in the autonomic nervous system and to predict cardiac events in patients with heart failure (HF). HRV measurements with heart rate monitors have been validated with an electrocardiograph in healthy subjects but not in patients with HF. We explored the reproducibility of HRV in two consecutive six-minute walk tests (6MW), 60-minute apart, using a heart rate monitor (PolarS810i) and a portable electrocardiograph (called Holter) in 50 HF patients (mean age 59 years, NYHA II, left ventricular ejection fraction ~35%). The reproducibility for each device was analysed using a paired t-test or the Wilcoxon signed-rank test. Additionally, we assessed the agreement between the two devices based on the HRV indices at rest, during the 6MW and during recovery using concordance correlation coefficients (CCC), 95% confidence intervals and Bland-Altman plots. The test-retest for the HRV analyses was reproducible using Holter and PolarS810i at rest but not during recovery. In the second 6MW, patients showed significant increases in rMSSD and walking distance. The PolarS810i measurements had remarkably high concordance correlation [0.86

Unabated global surface temperature warming: evaluating the evidence

NASA Astrophysics Data System (ADS)

Karl, T. R.; Arguez, A.

2015-12-01

New insights related to time-dependent bias corrections in global surface temperatures have led to higher rates of warming over the past few decades than previously reported in the IPCC Fifth Assessment Report (2014). Record high global temperatures in the past few years have also contributed to larger trends. The combination of these factors and new analyses of the rate of temperature change show unabated global warming since at least the mid-Twentieth Century. New time-dependent bias corrections account for: (1) differences in temperatures measured from ships and drifting buoys; (2) improved corrections to ship measured temperatures; and (3) the larger rates of warming in polar regions (particularly the Arctic). Since 1951, the period over which IPCC (2014) attributes over half of the observed global warming to human causes, it is shown that there has been a remarkably robust and sustained warming, punctuated with inter-annual and decadal variability. This finding is confirmed through simple trend analysis and Empirical Mode Decomposition (EMD). Trend analysis however, especially for decadal trends, is sensitive to selection bias of beginning and ending dates. EMD has no selection bias. Additionally, it can highlight both short- and long-term processes affecting the global temperature times series since it addresses both non-linear and non-stationary processes. For the new NOAA global temperature data set, our analyses do not support the notion of a hiatus or slowing of long-term global warming. However, sub-decadal periods of little (or no warming) and rapid warming can also be found, clearly showing the impact of inter-annual and decadal variability that previously has been attributed to both natural and human-induced non-greenhouse forcings.

Large-Scale Atmospheric Teleconnection Patterns Associated with the Interannual Variability of Heatwaves in East Asia and Its Decadal Changes

NASA Astrophysics Data System (ADS)

Choi, N.; Lee, M. I.; Lim, Y. K.; Kim, K. M.

2017-12-01

Heatwave is an extreme hot weather event which accompanies fatal damage to human health. The heatwave has a strong relationship with the large-scale atmospheric teleconnection patterns. In this study, we examine the spatial pattern of heatwave in East Asia by using the EOF analysis and the relationship between heatwave frequency and large-scale atmospheric teleconnection patterns. We also separate the time scale of heatwave frequency as the time scale longer than a decade and the interannual time scale. The long-term variation of heatwave frequency in East Asia shows a linkage with the sea surface temperature (SST) variability over the North Atlantic with a decadal time scale (a.k.a. the Atlantic Multidecadal Oscillation; AMO). On the other hands, the interannual variation of heatwave frequency is linked with the two dominant spatial patterns associated with the large-scale teleconnection patterns mimicking the Scandinavian teleconnection (SCAND-like) pattern and the circumglobal teleconnection (CGT-like) pattern, respectively. It is highlighted that the interannual variation of heatwave frequency in East Asia shows a remarkable change after mid-1990s. While the heatwave frequency was mainly associated with the CGT-like pattern before mid-1990s, the SCAND-like pattern becomes the most dominant one after mid-1990s, making the CGT-like pattern as the second. This study implies that the large-scale atmospheric teleconnection patterns play a key role in developing heatwave events in East Asia. This study further discusses possible mechanisms for the decadal change in the linkage between heatwave frequency and the large-scale teleconnection patterns in East Asia such as early melting of snow cover and/or weakening of East Asian jet stream due to global warming.

The impact of DSM-5 on the diagnosis and severity indicator of eating disorders in a treatment-seeking sample.

PubMed

Nakai, Yoshikatsu; Nin, Kazuko; Noma, Shun'ichi; Teramukai, Satoshi; Fujikawa, Kei; Wonderlich, Stephen A

2017-11-01

To examine the impact of the DSM-5 on the diagnoses and severity indicators of eating disorders, we conducted a comparative study on the classification of eating disorders including subtypes of anorexia nervosa (AN) between the DSM-IV and DSM-5 criteria. In addition, we studied the association of the DSM-5 severity criteria and clinical variables. Participants were 304 outpatients, aged 16-45 years, with eating disorders, diagnosed using semi-structured clinical interviews and the eating disorder examination questionnaire (EDE-Q). The severity of AN, bulimia nervosa (BN), and binge-eating disorder (BED) was rated from mild to extreme using the DSM-5 severity criteria. The DSM-5 remarkably reduced the number of diagnoses in the residual category from 37.5% to 9.2% and effectively differentiated the diagnostic groups in eating disorder psychopathology. Unexpectedly, however, the scores of all the EDE-Q subscales significantly decreased as severity ratings increased in the DSM-5 AN. Furthermore, while the AN binge-eating/purging group reported significantly lower severity ratings than the AN restricting group, the former displayed more severe eating disorder psychopathology than the latter. In the BN and BED groups, the level of eating concern increased as severity ratings increased, but the severity groups did not differ on other eating pathology variables. The DSM-5 effectively reduced the reliance on residual categories and differentiated the diagnostic groups in eating disorder psychopathology. However, our findings show limited support for the DSM-5 severity specifiers for eating disorders. It is necessary to test additional clinical or functional variables for severity specifiers across eating disorders. © 2017 Wiley Periodicals, Inc.

On the Nature of the Hard X-ray Sources SWIFT J1907.3-2050, IGR J12123-5802 and IGR J19552+0044

NASA Technical Reports Server (NTRS)

Bernardini, F.; De Martino, D.; Mukai, K.; Falanga, M.; Andruchow, I.; Bonnet-Bidaud, J.-M.; Masetti, N.; Gonzalez Buitrago, D. H.; Mouchet, M.; Tovmassian, G.

2013-01-01

The INTEGRAL and Swift hard X-ray surveys have identified a large number of new sources, among which many are proposed as Cataclysmic Variables (CVs). Here we present the first detailed study of three X-ray selected CVs, Swift J1907.3-2050, IGRJ12123-5802, and IGRJ19552+0044 based on XMM-Newton, Suzaku, Swift observations and ground based optical and archival near-infrared/infrared data. Swift J1907.3-2050 is highly variable from hours to months-years at all wavelengths. No coherent X-ray pulses are detected but rather transient features. The X-ray spectrum reveals a multi-temperature optically thin plasma absorbed by complex neutral material and a soft black body component arising from a small area. These characteristics are remarkably similar to those observed in magnetic CVs. A supra-solar abundance of nitrogen could arise from nuclear processed material from the donor star. Swift J1907.3-2050 could be a peculiar magnetic CV with the second longest (20.82 hours) binary period. IGRJ12123-5802 is variable in the X-rays on a timescale of greater than or approximately 7.6 hours. No coherent pulsations are detected, but its spectral characteristics suggest that it could be a magnetic CV of the Intermediate Polar (IP) type. IGRJ19552+0044 shows two X-ray periods, approximately 1.38 hours and approximately 1.69 hours and a X-ray spectrum characterized by a multi-temperature plasma with little absorption. We derive a low accretion rate, consistent with a CV below the orbital period gap. Its peculiar near-infrared/infrared spectrum suggests a contribution from cyclotron emission. It could either be a pre-polar or an IP with the lowest degree of asynchronism.

On the Nature of the Hard X-Ray Sources SWIFT J1907.3-2050, IGR J12123-5802 and IGR J19552+0044

NASA Technical Reports Server (NTRS)

Bernardini, F.; deMartino, D; Mukai, K.; Falanga, M.; Andruchow, I.; Bonnet-Bidaud, J.-M.; Masetti, N.; GonzalezBuitrago, D. H.; Mouchet, M.; Tovmassian, G.

2014-01-01

The INTEGRAL and Swift hard X-ray surveys have identified a large number of new sources, among which many are proposed as Cataclysmic Variables (CVs). Here we present the first detailed study of three X-ray selected CVs, Swift J1907.3-2050, IGRJ12123-5802, and IGRJ19552+0044 based on XMM-Newton, Suzaku, Swift observations and ground based optical and archival nIR/IR data. Swift J1907.3-2050 is highly variable from hours to monthsyears at all wavelengths. No coherent X-ray pulses are detected but rather transient features. The X-ray spectrum reveals a multi-temperature optically thin plasma absorbed by complex neutral material and a soft black body component arising from a small area. These characteristics are remarkably similar to those observed in magnetic CVs. A supra-solar abundance of nitrogen could arise from nuclear processed material from the donor star. Swift J1907.3-2050 could be a peculiar magnetic CV with the second longest (20.82 h) binary period. IGRJ12123-5802 is variable in the X-rays on a timescale of approximately or greater than 7.6 h. No coherent pulsations are detected, but its spectral characteristics suggest that it could be a magnetic CV of the Intermediate Polar (IP) type. IGRJ19552+0044 shows two X-ray periods, approximately 1.38 h and approximately 1.69 h and a X-ray spectrum characterized by a multi-temperature plasma with little absorption.We derive a low accretion rate, consistent with a CV below the orbital period gap. Its peculiar nIR/IR spectrum suggests a contribution from cyclotron emission. It could either be a pre-polar or an IP with the lowest degree of asynchronism.

Technical Stability and Biological Variability in MicroRNAs from Dried Blood Spots: A Lung Cancer Therapy-Monitoring Showcase.

PubMed

Kahraman, Mustafa; Laufer, Thomas; Backes, Christina; Schrörs, Hannah; Fehlmann, Tobias; Ludwig, Nicole; Kohlhaas, Jochen; Meese, Eckart; Wehler, Thomas; Bals, Robert; Keller, Andreas

2017-09-01

Different work flows have been proposed to use miRNAs as blood-borne biomarkers. In particular, the method used for collecting blood from patients can considerably influence the diagnostic results. We explored whether dried blood spots (DBSs) facilitate stable miRNA measurements and compared its technical stability with biological variability. First, we tested the stability of DBS samples by generating from 1 person 18 whole-genome-wide miRNA profiles of DBS samples that were exposed to different temperature and humidity conditions. Second, we investigated technical reproducibility by performing 7 replicates of DBS again from 1 person. Third, we investigated DBS samples from 53 patients with lung cancer undergoing different therapies. Across these 3 stages, 108 genome-wide miRNA profiles from DBS were generated and evaluated biostatistically. In the stability analysis, we observed that temperature and humidity had an overall limited influence on the miRNomes (average correlation between the different conditions of 0.993). Usage of a silica gel slightly diminished DBS' technical reproducibility. The 7 technical replicates had an average correlation of 0.996. The correlation with whole-blood PAXGene miRNomes of the same individual was remarkable (correlation of 0.88). Finally, evaluation of the samples from the 53 patients with lung cancer exposed to different therapies showed that the biological variations exceeded the technical variability significantly ( P < 0.0001), yielding 51 dysregulated miRNAs. We present a stable work flow for profiling of whole miRNomes on the basis of samples collected from DBS. Biological variations exceeded technical variations significantly. DBS-based miRNA profiles will potentially further the translational character of miRNA biomarker studies. © 2017 American Association for Clinical Chemistry.

Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server.

PubMed

Abriata, Luciano A; Bovigny, Christophe; Dal Peraro, Matteo

2016-06-17

Protein variability can now be studied by measuring high-resolution tolerance-to-substitution maps and fitness landscapes in saturated mutational libraries. But these rich and expensive datasets are typically interpreted coarsely, restricting detailed analyses to positions of extremely high or low variability or dubbed important beforehand based on existing knowledge about active sites, interaction surfaces, (de)stabilizing mutations, etc. Our new webserver PsychoProt (freely available without registration at http://psychoprot.epfl.ch or at http://lucianoabriata.altervista.org/psychoprot/index.html ) helps to detect, quantify, and sequence/structure map the biophysical and biochemical traits that shape amino acid preferences throughout a protein as determined by deep-sequencing of saturated mutational libraries or from large alignments of naturally occurring variants. We exemplify how PsychoProt helps to (i) unveil protein structure-function relationships from experiments and from alignments that are consistent with structures according to coevolution analysis, (ii) recall global information about structural and functional features and identify hitherto unknown constraints to variation in alignments, and (iii) point at different sources of variation among related experimental datasets or between experimental and alignment-based data. Remarkably, metabolic costs of the amino acids pose strong constraints to variability at protein surfaces in nature but not in the laboratory. This and other differences call for caution when extrapolating results from in vitro experiments to natural scenarios in, for example, studies of protein evolution. We show through examples how PsychoProt can be a useful tool for the broad communities of structural biology and molecular evolution, particularly for studies about protein modeling, evolution and design.

An eLIMA model for the 67 s X-ray periodicity in CAL 83

NASA Astrophysics Data System (ADS)

Odendaal, A.; Meintjes, P. J.

2017-05-01

Supersoft X-ray sources (SSSs) are characterized by their low effective temperatures and high X-ray luminosities. The soft X-ray emission can be explained by hydrogen nuclear burning on the surface of a white dwarf (WD) accreting at an extremely high rate. A peculiar ˜67 s periodicity (P67) was previously discovered in the XMM-Newton light curves of the SSS CAL 83. P67 was detected in X-ray light curves spanning ˜9 yr, but exhibits variability of several seconds on time-scales as short as a few hours, and its properties are remarkably similar to those of dwarf nova oscillations (DNOs). DNOs are short time-scale modulations (≲1 min) often observed in dwarf novae during outburst. DNOs are explained by the well-established low-inertia magnetic accretor (LIMA) model. In this paper, we show that P67 and its associated period variability can be satisfactorily explained by an application of the LIMA model to the more 'extreme' environment in an SSS (eLIMA), contrary to another recent study attempting to explain P67 and its associated variability in terms of non-radial g-mode oscillations in the extended envelope of the rapidly accreting WD in CAL 83. In the eLIMA model, P67 originates in an equatorial belt in the WD envelope at the boundary with the inner accretion disc, with the belt weakly coupled to the WD core by an ˜105 G magnetic field. New optical light curves obtained with the Sutherland High-speed Optical Camera are also presented, exhibiting quasi-periodic modulations on time-scales of ˜1000 s, compatible with the eLIMA framework.

Re-Examination of the Observed Decadal Variability of Earth Radiation Budget Using Altitude-Corrected ERBE/ERBS Nonscanner WFOV Data

NASA Technical Reports Server (NTRS)

Wong, Takmeng; Wielicki, Bruce A.; Lee, Robert B.; Smith, G. Louis; Bush, Kathryn A.

2005-01-01

This paper gives an update on the observed decadal variability of Earth Radiation Budget using the latest altitude-corrected Earth Radiation Budget Experiment (ERBE)/Earth Radiation Budget Satellite (ERBS) Nonscanner Wide Field of View (WFOV) instrument Edition3 dataset. The effects of the altitude correction are to modify the original reported decadal changes in tropical mean (20N to 20S) longwave (LW), shortwave (SW), and net radiation between the 1980s and the 1990s from 3.1/-2.4/-0.7 to 1.6/-3.0/1.4 Wm(sup -2) respectively. In addition, a small SW instrument drift over the 15-year period was discovered during the validation of the WFOV Edition3 dataset. A correction was developed and applied to the Edition3 dataset at the data user level to produce the WFOV Edition3_Rev1 dataset. With this final correction, the ERBS Nonscanner observed decadal changes in tropical mean LW, SW, and net radiation between the 1980s and the 1990s now stand at 0.7/-2.1/1.4 Wm(sup -2), respectively, which are similar to the observed decadal changes in the HIRS Pathfinder OLR and the ISCCP FD record; but disagree with the AVHRR Pathfinder ERB record. Furthermore, the observed interannual variability of near-global ERBS WFOV Edition3_Rev1 net radiation is found to be remarkably consistent with the latest ocean heat storage record for the overlapping time period of 1993 to 1999. Both data sets show variations of roughly 1.5 Wm(sup -2) in planetary net heat balance during the 1990s.

Genetic variation in parthenogenetic Caucasian rock lizards of the genus Lacerta (L. dahli, L. armeniaca, L. unisexualis) analyzed by DNA fingerprinting.

PubMed

Tokarskaya, O N; Kan, N G; Petrosyan, V G; Martirosyan, I A; Grechko, V V; Danielyan, F D; Darevsky, I S; Ryskov, A P

2001-07-01

Multilocus DNA fingerprinting has been used to study the variability of some mini- and microsatellite sequences in parthenogenetic species of Caucasian rock lizards of the genus Lacerta (L. dahli, L. armeniaca and L. unisexualis). We demonstrate that these clonally reproducing lizards possess species-specific DNA fingerprints with a low degree of intra- and interpopulation variation. Mean indices of similarity obtained using M13 DNA, (GACA)4 and (TCC)50 as probes were 0.962 and 0.966 in L. dahli and L. armeniaca, respectively. The mean index of similarity obtained using M 13 and GATA probes in L. unisexualis was estimated to be 0.95. However, despite the high degree of band-sharing, variable DNA fragments were revealed in all populations with the microsatellite probes. An particularly high level of variability was observed for (TCC)n microsatellites in populations of L. unisexualis. In fact TCC-derived DNA fingerprints were close to being individual-specific, with a mean index of similarity of 0.824. Fingerprint analysis of parthenogenetic families of L. armeniaca showed that all maternal fragments were inherited together by the progeny, and no differences in fingerprint patterns were observed. On the other hand, while identical DNA fingerprints were obtained from L. unisexualis families with M13 and (GATA)4 probes, use of the (TCC)50 probe revealed remarkable intrafamily variation in this species. It is assumed that the genetic heterogeneity observed in parthenogenetic populations may be explained, at least in part, by the existence of genetically unstable microsatellite loci. Our data serve to illustrate processes of spontaneous mutagenesis and the initial stages of clonal differentiation in natural populations of the lizard species studied.

Geochemistry of glass and olivine from Keanakako`i Tephra at Kilauea Volcano, Hawai`i

NASA Astrophysics Data System (ADS)

Garcia, M. O.; Mucek, A. E.; Swanson, D.

2011-12-01

Kilauea Volcano is well known for its frequent quiescent eruptions. However, it also has an underappreciated explosive past. Recent field work has documented many details of the Keanakako`i Tephra, which was generated during a period of explosive activity when few lava flows were erupted. The dominantly phreatomagmatic eruptions, which produced the Keanakako`i Tephra, began late in, or completely after, the formation of Kilauea Caldera (ca. 1500 CE) and continued sporadically until 1823. Thereafter, effusive eruptions outside the caldera resumed and have continued to the present.The Keanakako`i deposits provide an opportunity to examine the restoration of Kilauea's magmatic plumbing following caldera formation. Glassy products with variable amounts of olivine dominate from ca. 1500 A.D. to the late 1600 A.D., whereas lithic-rich deposits with sparse glass are common in the 1700 A.D. deposits, which include the deadly explosive activity of A.D. 1790. Glass compositions from tephra and basalt flows show remarkable MgO variations (4-11 wt percent), larger than those observed in glasses from subsequent eruptions. Some units have variable MgO indicating a zoned magma reservoir, whereas some others have variable incompatible element ratios suggesting magma mixing. The highest MgO values (>10 wt percent) are from 1500 A.D. and 1823 deposits. The range of parental magma compositions based on tephra glasses erupted over a 300 year period is comparable to those observed for the first 15 years of the Pu`u `O`o eruption and about half of the variation observed for summit eruptions from 1832 to 1982. The limited range in tephra parental magma compositions may be related to a lower magma production rate during the period the tephra was erupted.

Pancreas cancer meets the thunder god.

PubMed

Hingorani, Sunil R; Potter, John D

2012-10-17

A new formulation of a natural product shows remarkable activity against pancreatic ductal adenocarcinoma across a number of preclinical model systems. These findings set the stage for a clinical trial.

An analysis of the decadal variability of Carbon fluxes in three evergreen European forests through modelling

NASA Astrophysics Data System (ADS)

Delpierre, N.; Dufrêne, E.

2009-04-01

With several sites measuring mass and energy turbulent fluxes for more than ten years, the CarboEurope database appears as a valuable resource for addressing the question of the determinism of the interannual variability of carbon (C) and water balances in forests ecosystems. Apart from major climate-driven anomalies during the anomalous 2003 summer and 2007 spring, little is known about the factors driving interannual variability (IAV) of the C balance in forest ecosystems. We used the CASTANEA process-based model to simulate the C and W fluxes and balances of three European evergreen forests for the 2000-2007 period (FRPue Quercus ilex, 44°N; DETha Picea abies, 51°N; FIHyy Pinus sylvestris, 62°N). The model fairly reproduced the day-to-day variability of measured fluxes, accounting for 70-81%, 77-91% and 59-90% of the daily variance of measured NEP, GPP and TER, respectively. However, the model was challenged in representing the IAV of fluxes integrated on an annual time scale. It reproduced ca. 80% of the interannual variance of measured GPP, but no significant relationship could be established between annual measured and modelled NEP or TER. Accordingly, CASTANEA appeared as a suitable tool for disentangling the influence of climate and biological processes on GPP at mutiple time scales. We show that climate and biological processes relative influences on the modelled GPP vary from year to year in European evergreen forests. Water-stress related and phenological processes (i.e. release of the winter thermal constraint on photosynthesis in evergreens) appear as primary drivers for the particular 2003 and 2007 years, respectively, but the relative influence of other climatic factors widely varies for less remarkable years at all sites. We discuss shortcomings of the method, as related to the influence of compensating errors in the simulated fluxes, and assess the causes of the model poor ability to represent the IAV of the annual sums of NEP and TER.

Temperature Values Variability in Piezoelectric Implant Site Preparation: Differences between Cortical and Corticocancellous Bovine Bone.

PubMed

Lamazza, Luca; Garreffa, Girolamo; Laurito, Domenica; Lollobrigida, Marco; Palmieri, Luigi; De Biase, Alberto

2016-01-01

Various parameters can influence temperature rise and detection during implant site preparation. The aim of this study is to investigate local temperature values in cortical and corticocancellous bovine bone during early stages of piezoelectric implant site preparation. 20 osteotomies were performed using a diamond tip (IM1s, Mectron Medical Technology, Carasco, Italy) on two different types of bovine bone samples, cortical and corticocancellous, respectively. A standardized protocol was designed to provide constant working conditions. Temperatures were measured in real time at a fixed position by a fiber optic thermometer. Significantly higher drilling time (154.90 sec versus 99.00 sec; p < 0.0001) and temperatures (39.26°C versus 34.73°C; p = 0.043) were observed in the cortical group compared to the corticocancellous group. A remarkable variability of results characterized the corticocancellous blocks as compared to the blocks of pure cortical bone. Bone samples can influence heat generation during in vitro implant site preparation. When compared to cortical bone, corticocancellous samples present more variability in temperature values. Even controlling most experimental factors, the impact of bone samples still remains one of the main causes of temperature variability.

The Chemical Compositions of the SRD Variable Stars. III. KK Aquilae, AG Aurigae, Z Aurigae, W Leo Minoris, and WW Tauri

NASA Astrophysics Data System (ADS)

Giridhar, Sunetra; Lambert, David L.; Gonzalez, Guillermo

2000-12-01

Chemical compositions are derived from high-resolution spectra for five field SRd variables. These supergiants not previously analyzed are shown to be metal poor: KK Aql with [Fe/H]=-1.2, AG Aur with [Fe/H]=-1.8, Z Aur with [Fe/H]=-1.4, W LMi with [Fe/H]=-1.1, and WW Tau with [Fe/H]=-1.1. Their compositions are, except for two anomalies, identical to within the measurement errors to the compositions of subdwarfs, subgiants, and less evolved giants of the same [Fe/H]. One anomaly is an s-process enrichment for KK Aql, the first such enrichment reported for an SRd variable. The second and more remarkable anomaly is a strong lithium enrichment for W LMi, also a first for field SRd variables. The Li I λ6707 profile is not simply that of a photospheric line but includes strong absorption from redshifted gas, suggesting, perhaps, that lithium enrichment results from accretion of Li-rich gas. This potential clue to lithium enrichment is discussed in light of various proposals for lithium synthesis in evolved stars.

Small angle neutron scattering study on the structural variation of lysozyme in bioprotectants

NASA Astrophysics Data System (ADS)

Koda, Shota; Takayama, Haruki; Shibata, Tomohiko; Mori, Tatsuya; Kojima, Seiji; Park, In-Sung; Shin, Tae-Gyu

2015-05-01

The thermal denaturation and subsequent structural variation of lysozyme in various bioprotectant candidate solutions such as trehalose and choline acetate have been investigated by using small angle neutron scattering and differential scanning calorimetry. The gyration radius shows little change with the addition of additives in a native state at room temperature. On heating the lysozyme solution, a remarkable increase in the gyration radius is observed at temperatures above the denaturation temperature without any bioprotectants. Such an increase is suppressed by the additives owing to the intermolecular interactions between the lysozyme molecules and the bioprotectants of trehalose and choline acetate. The fractal dimension of lysozyme varies slightly with the addition of the bioprotectant solutions, and shows a remarkable drop in the vicinity of the denaturation temperature for all the solutions.

Tailoring porosity and rotational dynamics in a series of octacarboxylate metal-organic frameworks

PubMed Central

Moreau, Florian; Kolokolov, Daniil I.; Stepanov, Alexander G.; Easun, Timothy L.; Dailly, Anne; Blake, Alexander J.; Nowell, Harriott; Lennox, Matthew J.; Yang, Sihai; Schröder, Martin

2017-01-01

Modulation and precise control of porosity of metal-organic frameworks (MOFs) is of critical importance to their materials function. Here we report modulation of porosity for a series of isoreticular octacarboxylate MOFs, denoted MFM-180 to MFM-185, via a strategy of selective elongation of metal-organic cages. Owing to the high ligand connectivity, these MOFs do not show interpenetration, and are robust structures that have permanent porosity. Interestingly, activated MFM-185a shows a high Brunauer–Emmett–Teller (BET) surface area of 4,734 m2 g−1 for an octacarboxylate MOF. These MOFs show remarkable CH4 and CO2 adsorption properties, notably with simultaneously high gravimetric and volumetric deliverable CH4 capacities of 0.24 g g−1 and 163 vol/vol (298 K, 5–65 bar) recorded for MFM-185a due to selective elongation of tubular cages. The dynamics of molecular rotors in deuterated MFM-180a-d16 and MFM-181a-d16 were investigated by variable-temperature 2H solid-state NMR spectroscopy to reveal the reorientation mechanisms within these materials. Analysis of the flipping modes of the mobile phenyl groups, their rotational rates, and transition temperatures paves the way to controlling and understanding the role of molecular rotors through design of organic linkers within porous MOF materials. PMID:28280097

Global Patterns of Bacterial Beta-Diversity in Seafloor and Seawater Ecosystems

PubMed Central

Zinger, Lucie; Amaral-Zettler, Linda A.; Fuhrman, Jed A.; Horner-Devine, M. Claire; Huse, Susan M.; Welch, David B. Mark; Martiny, Jennifer B. H.; Sogin, Mitchell; Boetius, Antje; Ramette, Alban

2011-01-01

Background Marine microbial communities have been essential contributors to global biomass, nutrient cycling, and biodiversity since the early history of Earth, but so far their community distribution patterns remain unknown in most marine ecosystems. Methodology/Principal Findings The synthesis of 9.6 million bacterial V6-rRNA amplicons for 509 samples that span the global ocean's surface to the deep-sea floor shows that pelagic and benthic communities greatly differ, at all taxonomic levels, and share <10% bacterial types defined at 3% sequence similarity level. Surface and deep water, coastal and open ocean, and anoxic and oxic ecosystems host distinct communities that reflect productivity, land influences and other environmental constraints such as oxygen availability. The high variability of bacterial community composition specific to vent and coastal ecosystems reflects the heterogeneity and dynamic nature of these habitats. Both pelagic and benthic bacterial community distributions correlate with surface water productivity, reflecting the coupling between both realms by particle export. Also, differences in physical mixing may play a fundamental role in the distribution patterns of marine bacteria, as benthic communities showed a higher dissimilarity with increasing distance than pelagic communities. Conclusions/Significance This first synthesis of global bacterial distribution across different ecosystems of the World's oceans shows remarkable horizontal and vertical large-scale patterns in bacterial communities. This opens interesting perspectives for the definition of biogeographical biomes for bacteria of ocean waters and the seabed. PMID:21931760

Spatial Linkage and Urban Expansion: AN Urban Agglomeration View

NASA Astrophysics Data System (ADS)

Jiao, L. M.; Tang, X.; Liu, X. P.

2017-09-01

Urban expansion displays different characteristics in each period. From the perspective of the urban agglomeration, studying the spatial and temporal characteristics of urban expansion plays an important role in understanding the complex relationship between urban expansion and network structure of urban agglomeration. We analyze urban expansion in the Yangtze River Delta Urban Agglomeration (YRD) through accessibility to and spatial interaction intensity from core cities as well as accessibility of road network. Results show that: (1) Correlation between urban expansion intensity and spatial indicators such as location and space syntax variables is remarkable and positive, while it decreases after rapid expansion. (2) Urban expansion velocity displays a positive correlation with spatial indicators mentioned above in the first (1980-1990) and second (1990-2000) period. However, it exhibits a negative relationship in the third period (2000-2010), i.e., cities located in the periphery of urban agglomeration developing more quickly. Consequently, the hypothesis of convergence of urban expansion in rapid expansion stage is put forward. (3) Results of Zipf's law and Gibrat's law show urban expansion in YRD displays a convergent trend in rapid expansion stage, small and medium-sized cities growing faster. This study shows that spatial linkage plays an important but evolving role in urban expansion within the urban agglomeration. In addition, it serves as a reference to the planning of Yangtze River Delta Urban Agglomeration and regulation of urban expansion of other urban agglomerations.

Methionine as a Precursor of Ethylene—Commentary

USDA-ARS?s Scientific Manuscript database

Lieberman et al. showed in a 1966 publication of Plant Physiology that methionine is a precursor of ethylene. It was the first paper that showed ethylene carbons are derived from carbons 3 and 4 of methionine. This paper catalyzed remarkable interest among plant biologists to elucidate the biosynth...

The L dwarf/T dwarf transition: Multiplicity, magnetic activity and mineral meteorology across the hydrogen burning limit

NASA Astrophysics Data System (ADS)

Burgasser, A. J.

2013-02-01

The transition between the L dwarf and T dwarf spectral classes is one of the most remarkable along the stellar/brown dwarf main sequence, separating sources with photospheres containing mineral condensate clouds from those containing methane and ammonia gases. Unusual characteristics of this transition include a 1 μm brightening between late L and early T dwarfs observed in both parallax samples and coeval binaries; a spike in the multiplicity fraction; evidence of increased photometric variability, possibly arising from patchy cloud structures; and a delayed transition for young, planetary-mass objects. All of these features can be explained if this transition is governed by the ``rapid'' (nonequlibrium) rainout of clouds from the photosphere, triggered by temperature, surface gravity, metallicity and (perhaps) rotational effects. While the underlying mechanism of this rainout remains under debate, the transition is now being exploited to discover and precisely characterize tight (<1 AU) very low-mass binaries that can be used to test brown dwarf evolutionary and atmospheric theories, and resolved binaries that further constrain the properties of this remarkable transition.

Heterogeneity of Developmental Dyscalculia: Cases with Different Deficit Profiles

PubMed Central

Träff, Ulf; Olsson, Linda; Östergren, Rickard; Skagerlund, Kenny

2017-01-01

Developmental Dyscalculia (DD) has long been thought to be a monolithic learning disorder that can be attributed to a specific neurocognitive dysfunction. However, recent research has increasingly recognized the heterogeneity of DD, where DD can be differentiated into subtypes in which the underlying cognitive deficits and neural dysfunctions may differ. The aim was to further understand the heterogeneity of developmental dyscalculia (DD) from a cognitive psychological perspective. Utilizing four children (8–9 year-old) we administered a comprehensive cognitive test battery that shed light on the cognitive-behavioral profile of each child. The children were compared against norm groups of aged-matched peers. Performance was then contrasted against predominant hypotheses of DD, which would also give insight into candidate neurocognitive correlates. Despite showing similar mathematical deficits, these children showed remarkable interindividual variability regarding cognitive profile and deficits. Two cases were consistent with the approximate number system deficit account and also the general magnitude-processing deficit account. These cases showed indications of having domain-general deficits as well. One case had an access deficit in combination with a general cognitive deficit. One case suffered from general cognitive deficits only. The results showed that DD cannot be attributed to a single explanatory factor. These findings support a multiple deficits account of DD and suggest that some cases have multiple deficits, whereas other cases have a single deficit. We discuss a previously proposed distinction between primary DD and secondary DD, and suggest hypotheses of dysfunctional neurocognitive correlates responsible for the displayed deficits. PMID:28101068

Heterogeneity of Developmental Dyscalculia: Cases with Different Deficit Profiles.

PubMed

Träff, Ulf; Olsson, Linda; Östergren, Rickard; Skagerlund, Kenny

2016-01-01

Developmental Dyscalculia (DD) has long been thought to be a monolithic learning disorder that can be attributed to a specific neurocognitive dysfunction. However, recent research has increasingly recognized the heterogeneity of DD, where DD can be differentiated into subtypes in which the underlying cognitive deficits and neural dysfunctions may differ. The aim was to further understand the heterogeneity of developmental dyscalculia (DD) from a cognitive psychological perspective. Utilizing four children (8-9 year-old) we administered a comprehensive cognitive test battery that shed light on the cognitive-behavioral profile of each child. The children were compared against norm groups of aged-matched peers. Performance was then contrasted against predominant hypotheses of DD, which would also give insight into candidate neurocognitive correlates. Despite showing similar mathematical deficits, these children showed remarkable interindividual variability regarding cognitive profile and deficits. Two cases were consistent with the approximate number system deficit account and also the general magnitude-processing deficit account. These cases showed indications of having domain-general deficits as well. One case had an access deficit in combination with a general cognitive deficit. One case suffered from general cognitive deficits only. The results showed that DD cannot be attributed to a single explanatory factor. These findings support a multiple deficits account of DD and suggest that some cases have multiple deficits, whereas other cases have a single deficit. We discuss a previously proposed distinction between primary DD and secondary DD, and suggest hypotheses of dysfunctional neurocognitive correlates responsible for the displayed deficits.

Copy number variability of expression plasmids determined by cell sorting and Droplet Digital PCR.

PubMed

Jahn, Michael; Vorpahl, Carsten; Hübschmann, Thomas; Harms, Hauke; Müller, Susann

2016-12-19

Plasmids are widely used for molecular cloning or production of proteins in laboratory and industrial settings. Constant modification has brought forth countless plasmid vectors whose characteristics in terms of average plasmid copy number (PCN) and stability are rarely known. The crucial factor determining the PCN is the replication system; most replication systems in use today belong to a small number of different classes and are available through repositories like the Standard European Vector Architecture (SEVA). In this study, the PCN was determined in a set of seven SEVA-based expression plasmids only differing in the replication system. The average PCN for all constructs was determined by Droplet Digital PCR and ranged between 2 and 40 per chromosome in the host organism Escherichia coli. Furthermore, a plasmid-encoded EGFP reporter protein served as a means to assess variability in reporter gene expression on the single cell level. Only cells with one type of plasmid (RSF1010 replication system) showed a high degree of heterogeneity with a clear bimodal distribution of EGFP intensity while the others showed a normal distribution. The heterogeneous RSF1010-carrying cell population and one normally distributed population (ColE1 replication system) were further analyzed by sorting cells of sub-populations selected according to EGFP intensity. For both plasmids, low and highly fluorescent sub-populations showed a remarkable difference in PCN, ranging from 9.2 to 123.4 for ColE1 and from 0.5 to 11.8 for RSF1010, respectively. The average PCN determined here for a set of standardized plasmids was generally at the lower end of previously reported ranges and not related to the degree of heterogeneity. Further characterization of a heterogeneous and a homogeneous population demonstrated considerable differences in the PCN of sub-populations. We therefore present direct molecular evidence that the average PCN does not represent the true number of plasmid molecules in individual cells.

The brown anole dewlap revisited: do predation pressure, sexual selection, and species recognition shape among-population signal diversity?

PubMed Central

Van Damme, Raoul

2018-01-01

Animal signalling structures are amongst the most variable characteristics, as they are subjected to a diversity of selection pressures. A well-known example of a diverse signalling system in the animal kingdom is the dewlap of Anolis lizards. Dewlap characteristics can vary remarkably among and within species, and also between sexes. Although a considerable amount of studies have attempted to disentangle the functional significance of the staggering dewlap diversity in Anolis, the underlying evolutionary processes remain elusive. In this study, we focus on the contribution of biotic selective pressures in shaping geographic variation in dewlap design (size, colour, and pattern) and dewlap display behaviour at the intraspecific level. Notably, we have tried to replicate and extend previously reported results hereof in both sexes of the brown anole lizard (Anolis sagrei). To do this, we assembled a dataset consisting of 17 A. sagrei heterogeneous island populations from the Caribbean and specifically tested whether predation pressure, sexual selection, or species recognition could explain interpopulational variation in an array of dewlap characteristics. Our findings show that in neither males nor females estimates of predation pressure (island size, tail break frequency, model attack rate, presence of predatory Leiocephalus lizards) or sexual selection (sexual size dimorphism) could explain variation in dewlap design. We did find that A. sagrei males from larger islands showed higher dewlap display intensities than males from smaller islands, but the direct connection with predation pressure remains ambiguous and demands further investigation. Last, we could show indirect support for species recognition only in males, as they are more likely to have a ‘spotted’ dewlap pattern when co-occurring with a higher number of syntopic Anolis species. In conclusion, we found overall limited support for the idea that the extensive interpopulational variability in dewlap design and use in A. sagrei is mediated by variation in their biotic environment. We propose a variety of conceptual and methodological explanations for this unexpected finding. PMID:29761044

Household food insecurity and its association with school absenteeism among primary school adolescents in Jimma zone, Ethiopia.

PubMed

Tamiru, Dessalegn; Argaw, Alemayehu; Gerbaba, Mulusew; Ayana, Girmay; Nigussie, Aderajew; Belachew, Tefera

2016-08-17

Household food insecurity and lack of education are two of the most remarkable deprivations which developing countries are currently experiencing. Evidences from different studies showed that health and nutrition problems are major barriers to educational access and achievement in low-income countries which poses a serious challenge on effort towards the achieving Sustainable Development Goals. Evidence on the link between food security and school attendance is very important to address this challenge. This study aimed to assess to what extent food insecurity affects school absenteeism among primary school adolescents. A school based cross-sectional study was conducted among primary school adolescents in Jimma zone from October-November, 2013. Structured questionnaire was used to collect data on the household food security and socio-demographic variables. Data were analyzed using SPSS for windows version 16.0 after checking for missing values and outliers. Multivariable logistic regression analyses were used to determine the association of school absenteeism and food insecurity with independent variables using odds ratio and 95 % of confidence intervals. Variables with p ≤ 0.25 in the bivariate analyses were entered into a multivariable regression analysis to control for associations among the independent variables. The frequency of adolescent school absenteeism was significantly high (50.20 %) among food insecure households (P < 0.001) compared to their peers whose households were food secure (37.89 %). Findings of multivariable logistic regression analysis also showed that household food insecurity [AOR = 2.81 (1.70, 4.76)] was positively associated with poor school attendance while female-headed household [AOR = 0.23 (0.07, 0.72)], urban residence [AOR = 0.52 (0.36, 0.81)] and male-gender [AOR = 0.64 (0.54, 0.74)] were inversely associated with school absenteeism. Household food insecurity was positively associated with lack of maternal education [AOR = 2.26 (0.57, 8.93)] and poor household economic status [AOR = 1.39 (1.18, 2.83)]. However, livestock ownership [AOR = 0.17 (0.06, 0.51)] was negatively associated with household food insecurity. Findings of this study showed that household food insecurity has strong linkage with adolescent school absenteeism. Maternal education and household economic status were significantly associated with household food security status. Therefore, national policies and programs need to stress on how to improve family income earning capacity and socioeconomic status to handle household food insecurity which is a key contributor of adolescent school absenteeism.

Aging and Alzheimer's disease: lessons from the Nun Study.

PubMed

Snowdon, D A

1997-04-01

Sister Mary, the gold standard for the Nun Study, was a remarkable woman who had high cognitive test scores before her death at 101 years of age. What is more remarkable is that she maintained this high status despite having abundant neurofibrillary tangles and senile plaques, the classic lesions of Alzheimer's disease. Findings from Sister Mary and all 678 participants in the Nun Study may provide unique clues about the etiology of aging and Alzheimer's disease, exemplify what is possible in old age, and show how the clinical expression of some diseases may be averted.

Interplay between Peptide Bond Geometrical Parameters in Nonglobular Structural Contexts

PubMed Central

Esposito, Luciana; De Simone, Alfonso; Vitagliano, Luigi

2013-01-01

Several investigations performed in the last two decades have unveiled that geometrical parameters of protein backbone show a remarkable variability. Although these studies have provided interesting insights into one of the basic aspects of protein structure, they have been conducted on globular and water-soluble proteins. We report here a detailed analysis of backbone geometrical parameters in nonglobular proteins/peptides. We considered membrane proteins and two distinct fibrous systems (amyloid-forming and collagen-like peptides). Present data show that in these systems the local conformation plays a major role in dictating the amplitude of the bond angle N-Cα-C and the propensity of the peptide bond to adopt planar/nonplanar states. Since the trends detected here are in line with the concept of the mutual influence of local geometry and conformation previously established for globular and water-soluble proteins, our analysis demonstrates that the interplay of backbone geometrical parameters is an intrinsic and general property of protein/peptide structures that is preserved also in nonglobular contexts. For amyloid-forming peptides significant distortions of the N-Cα-C bond angle, indicative of sterical hidden strain, may occur in correspondence with side chain interdigitation. The correlation between the dihedral angles Δω/ψ in collagen-like models may have interesting implications for triple helix stability. PMID:24455689

Interplay between peptide bond geometrical parameters in nonglobular structural contexts.

PubMed

Esposito, Luciana; Balasco, Nicole; De Simone, Alfonso; Berisio, Rita; Vitagliano, Luigi

2013-01-01

Several investigations performed in the last two decades have unveiled that geometrical parameters of protein backbone show a remarkable variability. Although these studies have provided interesting insights into one of the basic aspects of protein structure, they have been conducted on globular and water-soluble proteins. We report here a detailed analysis of backbone geometrical parameters in nonglobular proteins/peptides. We considered membrane proteins and two distinct fibrous systems (amyloid-forming and collagen-like peptides). Present data show that in these systems the local conformation plays a major role in dictating the amplitude of the bond angle N-C(α)-C and the propensity of the peptide bond to adopt planar/nonplanar states. Since the trends detected here are in line with the concept of the mutual influence of local geometry and conformation previously established for globular and water-soluble proteins, our analysis demonstrates that the interplay of backbone geometrical parameters is an intrinsic and general property of protein/peptide structures that is preserved also in nonglobular contexts. For amyloid-forming peptides significant distortions of the N-C(α)-C bond angle, indicative of sterical hidden strain, may occur in correspondence with side chain interdigitation. The correlation between the dihedral angles Δω/ψ in collagen-like models may have interesting implications for triple helix stability.

Prevalence, phenotypic and genetic diversity of Campylobacter in poultry fresh meat and poultry products on retail sale in Tuscany (Italy).

PubMed

Pedonese, Francesca; Nuvoloni, Roberta; Turchi, Barbara; Torracca, Beatrice; Di Giannatale, Elisabetta; Marotta, Francesca; Cerri, Domenico

2017-03-31

In this study, the prevalence of Campylobacter spp. in poultry fresh meat and ready‑to‑cook products was evaluated. Seventy‑three samples were collected at retail level from supermarkets and discount stores, obtaining 61.6% positivity. Of 133 Campylobacter isolates, 86 strains (Campylobacter coli, 58.1% and Campylobacter jejuni, 41.9%) were selected for characterisation on the basis of their SmaI and kpnI pulsed field gel‑electrophoresis (PFGE) profiles, to exclude clonal replicates. Campylobacters resulted highly resistant to tetracycline, ciprofloxacin, and nalidixic acid (79.1%, 72.1% and 65.1%, respectively); 50% of C. coli and 13.9% of C. jejuni were resistant to ciprofloxacin and erythromycin, the most important antimicrobials for human campylobacteriosis therapy. Five C. coli were resistant to 5/7 of the tested antimicrobials. HS4c was the prevailing C. jejuni serotype group (22.3%), whereas 8 other serotypes were identified in low percentages. SmaI and kpnI profiles showed a wide variability. The survey showed a high Campylobacter contamination of poultry meat and poultry products at retail level in Tuscany, Italy. A wide strains' heterogeneity and a remarkable level of strains' antimicrobial resistance have been reported, confirming the need for an improvement of specific preventive measures along the production chain.

Consistency of biological networks inferred from microarray and sequencing data.

PubMed

Vinciotti, Veronica; Wit, Ernst C; Jansen, Rick; de Geus, Eco J C N; Penninx, Brenda W J H; Boomsma, Dorret I; 't Hoen, Peter A C

2016-06-24

Sparse Gaussian graphical models are popular for inferring biological networks, such as gene regulatory networks. In this paper, we investigate the consistency of these models across different data platforms, such as microarray and next generation sequencing, on the basis of a rich dataset containing samples that are profiled under both techniques as well as a large set of independent samples. Our analysis shows that individual node variances can have a remarkable effect on the connectivity of the resulting network. Their inconsistency across platforms and the fact that the variability level of a node may not be linked to its regulatory role mean that, failing to scale the data prior to the network analysis, leads to networks that are not reproducible across different platforms and that may be misleading. Moreover, we show how the reproducibility of networks across different platforms is significantly higher if networks are summarised in terms of enrichment amongst functional groups of interest, such as pathways, rather than at the level of individual edges. Careful pre-processing of transcriptional data and summaries of networks beyond individual edges can improve the consistency of network inference across platforms. However, caution is needed at this stage in the (over)interpretation of gene regulatory networks inferred from biological data.

Breaking the routine: individual Cory's shearwaters shift winter destinations between hemispheres and across ocean basins

PubMed Central

Dias, Maria P.; Granadeiro, José P.; Phillips, Richard A.; Alonso, Hany; Catry, Paulo

2011-01-01

There is growing evidence that migratory species are particularly vulnerable to rapid environmental changes arising from human activity. Species are expected to vary in their capacity to respond to these changes: long-distance migrants and those lacking variability in migratory traits are probably at considerable disadvantage. The few studies that have assessed the degree of plasticity in behaviour of marine animals suggest that fidelity to non-breeding destinations is usually high. In the present study, we evaluated individual flexibility in migration strategy of a highly pelagic seabird, the Cory's shearwater Calonectris diomedea. Geolocation data from 72 different migrations, including 14 birds that were tracked for more than one non-breeding season, showed a remarkable capacity to change winter destinations between years. Although some birds exhibited high site fidelity, others shifted from the South to North Atlantic, from the western to eastern South Atlantic, and from the Atlantic to Indian Ocean. Individuals also showed flexibility in stopover behaviour and migratory schedule. Although their K-selected life-history strategy has the disadvantage that the chances of microevolution are slight if circumstances alter rapidly, these results suggest that Cory's shearwaters may be in a better position than many other long-distance migrants to face the consequences of a changing environment. PMID:21106591

A silica long base tiltmeter with high stability and resolution.

PubMed

Boudin, F; Bernard, P; Longuevergne, L; Florsch, N; Larmat, C; Courteille, C; Blum, P-A; Vincent, T; Kammentaler, M

2008-03-01

In order to be able to provide valuable data in multiparameter measurement field operations, tiltmeters need to have a noise level better or equal than 10(-9) rad for a period range from a few minutes to a few years and a long term stability ranging from 10(-7) to 10(-8) rad/yr. Tiltmeter measurements should also be as much as possible insensitive to thermal disturbances, by taking great care of the horizontality of the base line tube first. Secondly, thermal responses have been assessed. We also took great care of the coupling of our tiltmeters with the bedrock. We've designed a long base tiltmeter with sensors in silica which has a low dilatation coefficient. The linear variable displacement transducer is based on coil coupling (powered by an alternative voltage). Finally we show the results of two 100 m silica water tube tiltmeters which were installed in a mine in the French Vosges massif in the framework of a hydrology research project. These instruments show a remarkably good stability (6.5x10(-9) rad/month) and a low noise level (of the order of 10(-11) rad). Toroidal and spheroidal free modes of the Earth were observed after the two last major earthquakes on Sumatra.

Education and health among U.S. working-age adults: a detailed portrait across the full educational attainment spectrum.

PubMed

Zajacova, Anna; Hummer, Robert A; Rogers, Richard G

2012-01-01

This article presents detailed estimates of relative and absolute health inequalities among U.S. working-age adults by educational attainment, including six postsecondary schooling levels. We also estimate the impact of several sets of mediating variables on the education-health gradient. Data from the 1997-2009 National Health Interview Survey (N = 178,103) show remarkable health differentials. For example, high school graduates have 3.5 times the odds of reporting "worse" health than do adults with professional or doctoral degrees. The probability of fair or poor health in mid-adulthood is less than 5 percent for adults with the highest levels of education but over 20 percent for adults without a high school diploma. The probability of reporting excellent health in the mid-forties is below 25 percent among high school graduates but over 50 percent for those adults who have professional degrees. These health differences characterize all the demographic subgroups examined in this study. Our results show that economic indicators and health behaviors explain about 40 percent of the education-health relationship. In the United States, adults with the highest educational degrees enjoy a wide array of benefits, including much more favorable self-rated health, compared to their less-educated counterparts.

Load capacity improvements in nucleic acid based systems using partially open feedback control.

PubMed

Kulkarni, Vishwesh; Kharisov, Evgeny; Hovakimyan, Naira; Kim, Jongmin

2014-08-15

Synthetic biology is facilitating novel methods and components to build in vivo and in vitro circuits to better understand and re-engineer biological networks. Recently, Kim and Winfree have synthesized a remarkably elegant network of transcriptional oscillators in vitro using a modular architecture of synthetic gene analogues and a few enzymes that, in turn, could be used to drive a variety of downstream circuits and nanodevices. However, these oscillators are sensitive to initial conditions and downstream load processes. Furthermore, the oscillations are not sustained since the inherently closed design suffers from enzyme deactivation, NTP fuel exhaustion, and waste product build up. In this paper, we show that a partially open architecture in which an [Symbol: see text]1 adaptive controller, implemented inside an in silico computer that resides outside the wet-lab apparatus, can ensure sustained tunable oscillations in two specific designs of the Kim-Winfree oscillator networks. We consider two broad cases of operation: (1) the oscillator network operating in isolation and (2) the oscillator network driving a DNA tweezer subject to a variable load. In both scenarios, our simulation results show a significant improvement in the tunability and robustness of these oscillator networks. Our approach can be easily adopted to improve the loading capacity of a wide range of synthetic biological devices.

Single-molecule analysis of the major glycopolymers of pathogenic and non-pathogenic yeast cells

NASA Astrophysics Data System (ADS)

El-Kirat-Chatel, Sofiane; Beaussart, Audrey; Alsteens, David; Sarazin, Aurore; Jouault, Thierry; Dufrêne, Yves F.

2013-05-01

Most microbes are coated with carbohydrates that show remarkable structural variability and play a crucial role in mediating microbial-host interactions. Understanding the functions of cell wall glycoconjugates requires detailed knowledge of their molecular organization, diversity and heterogeneity. Here we use atomic force microscopy (AFM) with tips bearing specific probes (lectins, antibodies) to analyze the major glycopolymers of pathogenic and non-pathogenic yeast cells at molecular resolution. We show that non-ubiquitous β-1,2-mannans are largely exposed on the surface of native cells from pathogenic Candida albicans and C. glabrata, the former species displaying the highest glycopolymer density and extensions. We also find that chitin, a major component of the inner layer of the yeast cell wall, is much more abundant in C. albicans. These differences in molecular properties, further supported by flow cytometry measurements, may play an important role in strengthening cell wall mechanics and immune interactions. This study demonstrates that single-molecule AFM, combined with immunological and fluorescence methods, is a powerful platform in fungal glycobiology for probing the density, distribution and extension of specific cell wall glycoconjugates. In nanomedicine, we anticipate that this new form of AFM-based nanoglycobiology will contribute to the development of sugar-based drugs, immunotherapeutics, vaccines and diagnostics.

Decadal trends in global pelagic ocean chlorophyll: A new assessment integrating multiple satellites, in situ data, and models.

PubMed

Gregg, Watson W; Rousseaux, Cécile S

2014-09-01

Quantifying change in ocean biology using satellites is a major scientific objective. We document trends globally for the period 1998-2012 by integrating three diverse methodologies: ocean color data from multiple satellites, bias correction methods based on in situ data, and data assimilation to provide a consistent and complete global representation free of sampling biases. The results indicated no significant trend in global pelagic ocean chlorophyll over the 15 year data record. These results were consistent with previous findings that were based on the first 6 years and first 10 years of the SeaWiFS mission. However, all of the Northern Hemisphere basins (north of 10° latitude), as well as the Equatorial Indian basin, exhibited significant declines in chlorophyll. Trend maps showed the local trends and their change in percent per year. These trend maps were compared with several other previous efforts using only a single sensor (SeaWiFS) and more limited time series, showing remarkable consistency. These results suggested the present effort provides a path forward to quantifying global ocean trends using multiple satellite missions, which is essential if we are to understand the state, variability, and possible changes in the global oceans over longer time scales.

Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection.

PubMed

Kuroda, Makoto; Yamashita, Atsushi; Hirakawa, Hideki; Kumano, Miyuki; Morikawa, Kazuya; Higashide, Masato; Maruyama, Atsushi; Inose, Yumiko; Matoba, Kimio; Toh, Hidehiro; Kuhara, Satoru; Hattori, Masahira; Ohta, Toshiko

2005-09-13

Staphylococcus saprophyticus is a uropathogenic Staphylococcus frequently isolated from young female outpatients presenting with uncomplicated urinary tract infections. We sequenced the whole genome of S. saprophyticus type strain ATCC 15305, which harbors a circular chromosome of 2,516,575 bp with 2,446 ORFs and two plasmids. Comparative genomic analyses with the strains of two other species, Staphylococcus aureus and Staphylococcus epidermidis, as well as experimental data, revealed the following characteristics of the S. saprophyticus genome. S. saprophyticus does not possess any virulence factors found in S. aureus, such as coagulase, enterotoxins, exoenzymes, and extracellular matrix-binding proteins, although it does have a remarkable paralog expansion of transport systems related to highly variable ion contents in the urinary environment. A further unique feature is that only a single ORF is predictable as a cell wall-anchored protein, and it shows positive hemagglutination and adherence to human bladder cell associated with initial colonization in the urinary tract. It also shows significantly high urease activity in S. saprophyticus. The uropathogenicity of S. saprophyticus can be attributed to its genome that is needed for its survival in the human urinary tract by means of novel cell wall-anchored adhesin and redundant uro-adaptive transport systems, together with urease.

Multivariate sequence analysis reveals additional function impacting residues in the SDR superfamily.

PubMed

Tiwari, Pratibha; Singh, Noopur; Dixit, Aparna; Choudhury, Devapriya

2014-10-01

The "extended" type of short chain dehydrogenases/reductases (SDR), share a remarkable similarity in their tertiary structures inspite of being highly divergent in their functions and sequences. We have carried out principal component analysis (PCA) on structurally equivalent residue positions of 10 SDR families using information theoretic measures like Jensen-Shannon divergence and average shannon entropy as variables. The results classify residue positions in the SDR fold into six groups, one of which is characterized by low Shannon entropies but high Jensen-Shannon divergence against the reference family SDR1E, suggesting that these positions are responsible for the specific functional identities of individual SDR families, distinguishing them from the reference family SDR1E. Site directed mutagenesis of three residues from this group in the enzyme UDP-Galactose 4-epimerase belonging to SDR1E shows that the mutants promote the formation of NADH containing abortive complexes. Finally, molecular dynamics simulations have been used to suggest a mechanism by which the mutants interfere with the re-oxidation of NADH leading to the formation of abortive complexes. © 2014 Wiley Periodicals, Inc.

Swarm intelligence in humans: A perspective of emergent evolution

NASA Astrophysics Data System (ADS)

Tao, Yong

2018-07-01

The origin of intelligence has fascinated scientists for a long time. Over the past 100 years, many scholars have observed the connection between entropy and intelligence. In the present study, we investigated a potential origin of the swarm intelligence in humans. The present study shows that a competitive economy consisting of a large number of self-interested agents can be mapped to a Boltzmann-like system, where entropy and energy play roles of swarm intelligence and income, respectively. However, different from the physical entropy in the Boltzmann system, the entropy (or swarm intelligence) in the economic system is a self-referential variable, which may be a key characteristic for distinguishing between biological and physical systems. Furthermore, we employ the household income data from 66 countries and Hong Kong SAR to test the validity of the Boltzmann-like distribution. Remarkably, the empirical data are perfectly consistent with the theoretical results. This finding implies that the competitive behaviors among a colony of self-interested agents will spontaneously prompt the colony to evolve to a state of higher technological level, although each agent has no willingness to evolve.

Dynamic Modeling of GAIT System Reveals Transcriptome Expansion and Translational Trickle Control Device

PubMed Central

Yao, Peng; Potdar, Alka A.; Arif, Abul; Ray, Partho Sarothi; Mukhopadhyay, Rupak; Willard, Belinda; Xu, Yichi; Yan, Jun; Saidel, Gerald M.; Fox, Paul L.

2012-01-01

SUMMARY Post-transcriptional regulatory mechanisms superimpose “fine-tuning” control upon “on-off” switches characteristic of gene transcription. We have exploited computational modeling with experimental validation to resolve an anomalous relationship between mRNA expression and protein synthesis. Differential GAIT (Gamma-interferon Activated Inhibitor of Translation) complex activation repressed VEGF-A synthesis to a low, constant rate despite high, variable VEGFA mRNA expression. Dynamic model simulations indicated the presence of an unidentified, inhibitory GAIT element-interacting factor. We discovered a truncated form of glutamyl-prolyl tRNA synthetase (EPRS), the GAIT constituent that binds the 3’-UTR GAIT element in target transcripts. The truncated protein, EPRSN1, prevents binding of functional GAIT complex. EPRSN1 mRNA is generated by a remarkable polyadenylation-directed conversion of a Tyr codon in the EPRS coding sequence to a stop codon (PAY*). By low-level protection of GAIT element-bearing transcripts, EPRSN1 imposes a robust “translational trickle” of target protein expression. Genome-wide analysis shows PAY* generates multiple truncated transcripts thereby contributing to transcriptome expansion. PMID:22386318

Optimization conditions for extracting polysaccharide from Angelica sinensis and its antioxidant activities.

PubMed

Tian, Suyang; Hao, Changchun; Xu, Guangkuan; Yang, Juanjuan; Sun, Runguang

2017-10-01

In this study, polysaccharides from Angelica sinensis were extracted using the ultrasound-assisted extraction method. Based on the results of single factor experiments and orthogonal tests, three independent variables-water/raw material ratio, ultrasound time, and ultrasound power-were selected for investigation. Then, we used response surface methodology to optimize the extraction conditions. The experimental data were fitted to a quadratic equation using multiple regression analysis, and the optimal conditions were as follows: water/raw material ratio, 43.31 mL/g; ultrasonic time, 28.06 minutes; power, 396.83 W. Under such conditions, the polysaccharide yield was 21.89±0.21%, which was well matched with the predicted yield. In vitro assays, scavenging activity of superoxide anion radicals, hydroxyl radicals, and 2,2-diphenyl-1-picry-hydrazyl radical showed that polysaccharides had certain antioxidant activities and that hydroxyl radicals have a remarkable scavenging capability. Therefore, these studies provide reference for further research and rational development of A. sinensis polysaccharide. Copyright © 2016. Published by Elsevier B.V.

Self-assembly of active colloidal molecules with dynamic function

NASA Astrophysics Data System (ADS)

Soto, Rodrigo; Golestanian, Ramin

2015-05-01

Catalytically active colloids maintain nonequilibrium conditions in which they produce and deplete chemicals and hence effectively act as sources and sinks of molecules. While individual colloids that are symmetrically coated do not exhibit any form of dynamical activity, the concentration fields resulting from their chemical activity decay as 1 /r and produce gradients that attract or repel other colloids depending on their surface chemistry and ambient variables. This results in a nonequilibrium analog of ionic systems, but with the remarkable novel feature of action-reaction symmetry breaking. We study solutions of such chemically active colloids in dilute conditions when they join up to form molecules via generalized ionic bonds and discuss how we can achieve structures with time-dependent functionality. In particular, we study a molecule that adopts a spontaneous oscillatory pattern of conformations and another that exhibits a run-and-tumble dynamics similar to bacteria. Our study shows that catalytically active colloids could be used for designing self-assembled structures that possess dynamical functionalities that are determined by their prescribed three-dimensional structures, a strategy that follows the design principle of proteins.

Divergent and nonuniform gene expression patterns in mouse brain

PubMed Central

Morris, John A.; Royall, Joshua J.; Bertagnolli, Darren; Boe, Andrew F.; Burnell, Josh J.; Byrnes, Emi J.; Copeland, Cathy; Desta, Tsega; Fischer, Shanna R.; Goldy, Jeff; Glattfelder, Katie J.; Kidney, Jolene M.; Lemon, Tracy; Orta, Geralyn J.; Parry, Sheana E.; Pathak, Sayan D.; Pearson, Owen C.; Reding, Melissa; Shapouri, Sheila; Smith, Kimberly A.; Soden, Chad; Solan, Beth M.; Weller, John; Takahashi, Joseph S.; Overly, Caroline C.; Lein, Ed S.; Hawrylycz, Michael J.; Hohmann, John G.; Jones, Allan R.

2010-01-01

Considerable progress has been made in understanding variations in gene sequence and expression level associated with phenotype, yet how genetic diversity translates into complex phenotypic differences remains poorly understood. Here, we examine the relationship between genetic background and spatial patterns of gene expression across seven strains of mice, providing the most extensive cellular-resolution comparative analysis of gene expression in the mammalian brain to date. Using comprehensive brainwide anatomic coverage (more than 200 brain regions), we applied in situ hybridization to analyze the spatial expression patterns of 49 genes encoding well-known pharmaceutical drug targets. Remarkably, over 50% of the genes examined showed interstrain expression variation. In addition, the variability was nonuniformly distributed across strain and neuroanatomic region, suggesting certain organizing principles. First, the degree of expression variance among strains mirrors genealogic relationships. Second, expression pattern differences were concentrated in higher-order brain regions such as the cortex and hippocampus. Divergence in gene expression patterns across the brain could contribute significantly to variations in behavior and responses to neuroactive drugs in laboratory mouse strains and may help to explain individual differences in human responsiveness to neuroactive drugs. PMID:20956311

Otolithic and extraocular muscle proprioceptive influences on the spatial organization of the vestibulo- and cervico-ocular quick phases.

PubMed

Pettorossi, V E; Manni, E; Errico, P; Ferraresi, A; Bortolami, R

1997-03-01

The cervico-ocular reflex (COR) was studied alone or in combination with the vestibulo-ocular reflex (VOR) in the rabbit. Step stimulations of the body with respect to the fixed head induced small slow compensatory responses followed by large compensatory quick phases (QP). These responses remained aligned with the horizon at different head pitch angles. The QP reorientation in space was due to the gravity influence on the otolithic receptors. The vestibular induced QPs exhibit a similar pattern. Because of this reorientation, the reduction of the amplitude of the vestibular induced QPs, due to the addition of the COR, was maintained even at different static head positions. The electrolytic lesion of the ophthalmic branch of the trigeminal nerve deeply affected the space orientation of the COR. In particular, the cervically induced compensatory QPs of the eye ipsilateral to the lesion showed a remarkable variability of their trajectories and they lost space reorientation. These findings suggest that the coordinate system controlling the QPs is influenced by signals originating from both head position in space and eye position in the orbit.

Phenotypic variability of Rhodnius ecuadoriensis populations at the Ecuadorian central and southern Andean region.

PubMed

Villacís, Anita G; Grijalva, Mario J; Catalá, Silvia S

2010-11-01

Rhodnius ecuadoriensis is an important vector of Chagas disease in Ecuador. Whereas only sylvatic and peridomestic populations are common in Manabi province, this species occupies domestic, peridomestic, and sylvatic habitats in Loja province where high reinfestation of houses was observed. To explore the existence of phenetic changes linked to the domiciliation of the species, this study set out to analyze the wing and antennal phenotypes of R. ecuadoriensis in these two provinces where the vector presents different affinity for domestic habitats. The antennal phenotype and the wing size and shape distinguish the two geographical populations of R. ecuadoriensis. In Manabí, sylvatic and peridomestic specimens were very similar. In Loja, sylvatic and nonsylvatic (domestic and peridomestic) populations showed distinctive characteristics. Remarkable sexual dimorphism of wing and antenna, exclusive of domestic specimens, and high metric disparity in the wing shape of the domestic females point out the existence of a particular situation in this habitat. The results of this phenotypic analysis and previous evidence of behavioral differences support the hypothesis of disruptive selection acting upon R. ecuadoriensis populations.

The Effect of Language Learning Strategies on Proficiency, Attitudes and School Achievement.

PubMed

Habók, Anita; Magyar, Andrea

2017-01-01

This study examines language learning strategy (LLS) use in connexion with foreign language attitude, proficiency and general school achievement among lower secondary students in Years 5 and 8 ( n = 868) in Hungary. An adapted version of the Strategies Inventory for Language Learning questionnaire was used for data collection. The results showed that Hungarian students mainly engage in metacognitive strategies in both years. Differences between more and less proficient language learners' strategy use have also been found. With regard to the effect of LLS on foreign language attitude, the foreign language mark and school achievement, path analysis indicated a good fit in both years. The metacognitive, social and memory strategies primarily influenced foreign language attitudes and marks in Year 5. The metacognitive strategies had a slight impact on school achievement as well as on foreign language marks. We demonstrated the dominant effect of metacognitive strategies and the low effect of memory strategies in Year 8. In addition, metacognitive strategies also influenced foreign language marks. The effect of foreign language marks on school achievement was also remarkable. There was a strong impact on the children's attitudes through these variables.

Homogeneity of lava flows - Chemical data for historic Mauna Loan eruptions

NASA Technical Reports Server (NTRS)

Rhodes, J. M.

1983-01-01

Chemical analyses of basalts collected from the major historic eruptions of Mauna Loa volcano show that many of the flow fields are remarkably homogeneous in composition. Despite their large size (lengths 9-85 km), large areal extents (13-114 sq km), and various durations of eruption (1-450 days), many of the flow fields have compositional variability that is within, or close to, the analytical error for most elements. The flow fields that are not homogeneous vary mainly in olivine content in an otherwise homogeneous melt. Some are composite flow fields made up of several, apparently homogeneous subunits erupted at different elevations along the active volcanic rifts. Not all volcanoes produce lavas that are homogeneous like those of Mauna Loa. If studies such as this are to be used to evaluate compositional diversity in lavas where there is a lack of sampling control, such as on other planets, it is necessary to understand why some flow units and flow fields are compositionally homogeneous and others are not, and to develop criteria for distinguishing between them.

Fermentation of Saccharomyces cerevisiae - Combining kinetic modeling and optimization techniques points out avenues to effective process design.

PubMed

Scheiblauer, Johannes; Scheiner, Stefan; Joksch, Martin; Kavsek, Barbara

2018-09-14

A combined experimental/theoretical approach is presented, for improving the predictability of Saccharomyces cerevisiae fermentations. In particular, a mathematical model was developed explicitly taking into account the main mechanisms of the fermentation process, allowing for continuous computation of key process variables, including the biomass concentration and the respiratory quotient (RQ). For model calibration and experimental validation, batch and fed-batch fermentations were carried out. Comparison of the model-predicted biomass concentrations and RQ developments with the corresponding experimentally recorded values shows a remarkably good agreement for both batch and fed-batch processes, confirming the adequacy of the model. Furthermore, sensitivity studies were performed, in order to identify model parameters whose variations have significant effects on the model predictions: our model responds with significant sensitivity to the variations of only six parameters. These studies provide a valuable basis for model reduction, as also demonstrated in this paper. Finally, optimization-based parametric studies demonstrate how our model can be utilized for improving the efficiency of Saccharomyces cerevisiae fermentations. Copyright © 2018 Elsevier Ltd. All rights reserved.

Comparative recruitment dynamics of Alewife and Bloater in Lakes Michigan and Huron

USGS Publications Warehouse

Collingsworth, Paris D.; Bunnell, David B.; Madenjian, Charles P.; Riley, Stephen C.

2014-01-01

The predictive power of recruitment models often relies on the identification and quantification of external variables, in addition to stock size. In theory, the identification of climatic, biotic, or demographic influences on reproductive success assists fisheries management by identifying factors that have a direct and reproducible influence on the population dynamics of a target species. More often, models are constructed as one-time studies of a single population whose results are not revisited when further data become available. Here, we present results from stock recruitment models for Alewife Alosa pseudoharengus and Bloater Coregonus hoyi in Lakes Michigan and Huron. The factors that explain variation in Bloater recruitment were remarkably consistent across populations and with previous studies that found Bloater recruitment to be linked to population demographic patterns in Lake Michigan. Conversely, our models were poor predictors of Alewife recruitment in Lake Huron but did show some agreement with previously published models from Lake Michigan. Overall, our results suggest that external predictors of fish recruitment are difficult to discern using traditional fisheries models, and reproducing the results from previous studies may be difficult particularly at low population sizes.

Nonviral RNA transfection to transiently modify T cells with chimeric antigen receptors for adoptive therapy.

PubMed

Riet, Tobias; Holzinger, Astrid; Dörrie, Jan; Schaft, Niels; Schuler, Gerold; Abken, Hinrich

2013-01-01

Redirecting T cells with a chimeric antigen receptor (CAR) of predefined specificity showed remarkable efficacy in the adoptive therapy trials of malignant diseases. The CAR consists of a single chain fragment of variable region (scFv) antibody targeting domain covalently linked to the CD3ζ signalling domain of the T cell receptor complex to mediate T cell activation upon antigen engagement. By using an antibody-derived targeting domain a CAR can potentially redirect T cells towards any target expressed on the cell surface as long as a binding domain is available. Antibody-mediated targeting moreover circumvents MHC restriction of the targeted antigen, thereby broadening the potential of applicability of adoptive T cell therapy. While T cells were so far genetically modified by viral transduction, transient modification with a CAR by RNA transfection gained increasing interest during the last years. This chapter focuses on methods to modify human T cells from peripheral blood with a CAR by electroporation of in vitro transcribed RNA and to test modified T cells for function for use in adoptive immunotherapy.

A novel mutation of the beta myosin heavy chain gene responsible for familial hypertrophic cardiomyopathy.

PubMed

Wang, Juan; Xu, Shi-Jie; Zhou, Hua; Wang, Li-Jie; Hu, Bo; Fang, Fang; Zhang, Xu-Min; Luo, Yi-Wei; He, Xiao-Yan; Zhuang, Shao-Wei; Li, Xin-Ming; Liu, Zhong-Ming; Hu, Da-Yi

2009-09-01

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder and shows high variability in genetic heterogeneity and phenotypic characteristics. The genetic etiology responsible for HCM in many individuals remains unclear. This instigation was sought to identify novel genetic determinants for familial hypertrophic cardiomyopathy. Six unrelated Chinese families with HCM were studied. For each of the 13 established HCM-susceptibility genes, 3 to 5 microsatellite markers were selected to perform genotyping and haplotype analysis. The linked genes were sequenced. Haplotype analyses on candidate genetic loci revealed cosegregation of the gene beta-myosin heavy chain (MYH7) with HCM in a single family. A novel double heterozygous missense mutation of Ala26Val plus Arg719Trp in MYH7 was subsequently identified by sequencing in this family and was associated with a severe phenotype of HCM. The novel double mutation of Ala26Val plus Arg719Trp in MYH7 identified in a Chinese family highlights the remarkable genetic heterogeneity of HCM, which provides important information for genetic counseling, accurate diagnosis, prognostic evaluation, and appropriate clinical management. Copyright 2009 Wiley Periodicals, Inc.

Distribution of phyllosilicates on Ceres

NASA Astrophysics Data System (ADS)

Ammannito, Eleonora; De Sanctis, Maria Cristina; Ciarniello, Mauro; Frigeri, Alessandro; Giacomo Carrozzo, Filippo; Combe, Jean Philippe; Ehlmann, Bethany; Marchi, Simone; McSween, Hap Y.; Raponi, Andrea; Castillo-Rogez, Julie C.; Toplis, Michael J.; Tosi, Federico; Longobardo, Andrea; Palomba, Ernesto; Pieters, Carle M.; Raymond, Carol A.; Schenk, Paul; Zambon, Francesca; Russell, Christopher T.

2016-04-01

Studies of the dwarf planet Ceres using ground-based and orbiting telescopes proposed a variety of possible surficial composition including water in clay minerals [1], ammoniated phyllosilicates [2], or a mixture of brucite, Mg2CO3 and iron-rich serpentine [3, 4]. But the lack of spectral data in the 2.5 to 2.9 μm interval has precluded definitive identifications. The Dawn spacecraft has been acquiring spectra of the surface of Ceres since January 2015 [5, 6, 7]. The average thermally corrected reflectance spectrum of Ceres shows that the 2.6-4.2μm region is characterized by a broad asymmetric feature, characteristic of H2O/OH bearing materials, with several distinct narrower absorption bands [8]. This spectrum is compatible with the presence on the surface of a mixture of ammoniated-phyllosilicates, Mg-phyllosilicates, carbonates, and dark materials [8]. A strong 2.7-μm absorption dominates the overall spectral properties, and it has been attributed to OH-stretching vibrations in phyllosilicates [9] while the weaker 3.05 μm absorption has been attributed to the presence of NH4+ in phyllosilicates [10]. The spectral parameters of the absorption features at 2.7 and 3.05 μm have been computed to study their position and intensity. The computed spectral position of both absorption features is remarkably homogeneous. The average values are 2.727±0.005 and 3.061±0.005 μm respectively. Since the position of both features is sensitive to the chemical composition of the phyllosilicates, we conclude that the composition of phyllosilicates does not significantly change across the mapped portion of Ceres' surface. The computed values are indicative of Mg-OH phases, like antigorite (Mg-serpentine) or saponite (Mg-smectite) [9]. The presence of Mg-, rather than Fe-serpentine on Ceres may be interpreted as an indication that alteration had been extensive, while the lack of geochemical variation indicates that this is true throughout the exposed upper layer with no significant compositional gradients. The computed spectral intensity of both absorption features shows some variability. For the 2.7 absorption, the average value is 0.251±0.006, while the range of variability is between 0.20 and 0.29. For the 3.05 absorption, the average value is 0.055±0.012, while the range of variability is between 0.03 and 0.09. Interestingly, the distributions of the intensities of the two bands broadly match. Among several possibilities, the most likely explanation for the variability in intensity is a changing abundance of phyllosilicates within the assemblage forming the surface of Ceres. In conclusion, while the chemical composition of the phyllosilicates is remarkably constant, their abundance is variable. The compositional homogeneity characterized by the pervasive presence of Mg- and NH4-bearing phyllosilicates indicates endogenous formation by a globally widespread and extensive alteration processes while the variations in the amount of phyllosilicate suggest the existence of a vertically stratified upper crust. References: [1] Lebofsky, L. et al. (1981) Icarus, 48, 453-459. [2] King T. et al. (1992) Science, 255, 1551-1553. [3] Rivkin A.S. et al. (2006) Icarus, 185, 563-567. [4] Milliken R.E. and Rivkin A.S. (2009) Nature Geosci., 2, 258-261. [5] Russell C.T. and Raymond C.A. (2011) Space Sci. Rev., 163, 3-23. [6] Russell C.T. et al. (2015) EPSC. [7] De Sanctis M.C. et al. (2011) Space Sci. Rev., 163, 329-369. [8] De Sanctis M.C. et al. (2015) Nature. [9] Bishop J.L. et al. (2008) ClayMiner., 43, 35-54. [10] Bishop J.L. et al. (2002) Planet. Space Sci., 50.

NTT, Spitzer, and Chandra Spectroscopy of SDSSJ095209.56+214313.3: The Most Luminous Coronal-line Supernova Ever Observed, or a Stellar Tidal Disruption Event?

NASA Astrophysics Data System (ADS)

Komossa, S.; Zhou, H.; Rau, A.; Dopita, M.; Gal-Yam, A.; Greiner, J.; Zuther, J.; Salvato, M.; Xu, D.; Lu, H.; Saxton, R.; Ajello, M.

2009-08-01

The galaxy SDSSJ095209.56+214313.3 (SDSSJ0952+2143 hereafter) showed remarkable emission-line and continuum properties and strong emission-line variability first reported in 2008 (Paper I). The spectral properties and low-energy variability are the consequence of a powerful high-energy flare which was itself not observed directly. Here we report follow-up optical, near-infrared (NIR), mid-infrared (MIR), and X-ray observations of SDSSJ0952+2143. We discuss outburst scenarios in terms of stellar tidal disruption by a supermassive black hole, peculiar variability of an active galactic nucleus (AGN), and a supernova (SN) explosion, and possible links between these scenarios and mechanisms. The optical spectrum of SDSSJ0952+2143 exhibits several peculiarities: an exceptionally high ratio of [Fe VII] transitions over [O III], a dramatic decrease by a factor of 10 of the highest-ionization coronal lines, a very unusual and variable Balmer line profile including a triple-peaked narrow component with two unresolved horns, and a large Balmer decrement. The MIR emission measured with the Spitzer IRS in the narrow 10-20 μm band is extraordinarily luminous and amounts to L 10-20 μm = 3.5 × 1043 erg s-1. The IRS spectrum shows a bump around ~11 μm and an increase toward longer wavelengths, reminiscent of silicate emission. The strong MIR excess over the NIR implies the dominance of relatively cold dust. The pre- and post-flare NIR host galaxy colors indicate a nonactive galaxy. The X-ray luminosity of L x,0.1-10 keV = 1041 erg s-1 measured with Chandra is below that typically observed in AGNs. Similarities of SDSSJ0952+2143 with some extreme SNe suggest the explosion of a SN of Type IIn. However, an extreme accretion event in a low-luminosity AGN or inactive galaxy, especially stellar tidal disruption, remain possibilities, which could potentially produce a very similar emission-line response. If indeed a SN, SDSSJ0952+2143 is one of the most distant X-ray- and MIR-detected SNe known so far, the most MIR luminous, and one of the most X-ray luminous. It is also by far the most luminous (>1040 erg s-1) in high-ionization coronal lines, exceeding previous SNe by at least a factor of 100.

Understanding climate impacts on vegetation using a spatiotemporal non-linear Granger causality framework

NASA Astrophysics Data System (ADS)

Papagiannopoulou, Christina; Decubber, Stijn; Miralles, Diego; Demuzere, Matthias; Dorigo, Wouter; Verhoest, Niko; Waegeman, Willem

2017-04-01

Satellite data provide an abundance of information about crucial climatic and environmental variables. These data - consisting of global records, spanning up to 35 years and having the form of multivariate time series with different spatial and temporal resolutions - enable the study of key climate-vegetation interactions. Although methods which are based on correlations and linear models are typically used for this purpose, their assumptions for linearity about the climate-vegetation relationships are too simplistic. Therefore, we adopt a recently proposed non-linear Granger causality analysis [1], in which we incorporate spatial information, concatenating data from neighboring pixels and training a joint model on the combined data. Experimental results based on global data sets show that considering non-linear relationships leads to a higher explained variance of past vegetation dynamics, compared to simple linear models. Our approach consists of several steps. First, we compile an extensive database [1], which includes multiple data sets for land surface temperature, near-surface air temperature, surface radiation, precipitation, snow water equivalents and surface soil moisture. Based on this database, high-level features are constructed and considered as predictors in our machine-learning framework. These high-level features include (de-trended) seasonal anomalies, lagged variables, past cumulative variables, and extreme indices, all calculated based on the raw climatic data. Second, we apply a spatiotemporal non-linear Granger causality framework - in which the linear predictive model is substituted for a non-linear machine learning algorithm - in order to assess which of these predictor variables Granger-cause vegetation dynamics at each 1° pixel. We use the de-trended anomalies of Normalized Difference Vegetation Index (NDVI) to characterize vegetation, being the target variable of our framework. Experimental results indicate that climate strongly (Granger-)causes vegetation dynamics in most regions globally. More specifically, water availability is the most dominant vegetation driver, being the dominant vegetation driver in 54% of the vegetated surface. Furthermore, our results show that precipitation and soil moisture have prolonged impacts on vegetation in semiarid regions, with up to 10% of additional explained variance on the vegetation dynamics occurring three months later. Finally, hydro-climatic extremes seem to have a remarkable impact on vegetation, since they also explain up to 10% of additional variance of vegetation in certain regions despite their infrequent occurrence. References [1] Papagiannopoulou, C., Miralles, D. G., Verhoest, N. E. C., Dorigo, W. A., and Waegeman, W.: A non-linear Granger causality framework to investigate climate-vegetation dynamics, Geosci. Model Dev. Discuss., doi:10.5194/gmd-2016-266, in review, 2016.

Observations of inertial oscillations affected by mesoscale activity in the Northeast Atlantic Ocean

NASA Astrophysics Data System (ADS)

Aguiar-González, B.; Hormazábal, S.; Rodríguez-Santana, A.; Cisneros-Aguirre, J.; Martínez-Marrero, A.

2012-04-01

Observations of surface drifters launched over the continental slope of Portugal (Bay of Setúbal) are analyzed with the Rotary Wavelet Spectrum Method to study the contribution of mesoscale activity to near-inertial variability. Drifter data used here are part of the MREA04 (Maritime Rapid Environmental Assessment 2004) sea trial carried out by the NATO Undersea Research Centre (NURC) off the west coast of Portugal. Altimetry data from AVISO on a 1/3° Mercator grid are used to compute vertical relative vorticity (ζ) maps and track near-inertial variability along the drifter records. Subsequently, the local Coriolis (f) and effective Coriolis (feff = f + 1/2ζ) frequencies are estimated for every drifter position. In this work we take a special interest in the area of Cape St. Vicent where a remarkable blue shift of near-inertial oscillations is observed in association with a cyclonic eddy migrating northward along the Portuguese coast. Results of the Rotary Wavelet Method highlight the consistency of near-inertial variability observed in the drifter records with the subinertial geostrophic activity computed with altimetry data.

Tropical Pacific variability as a key pacemaker of the global warming staircase

NASA Astrophysics Data System (ADS)

Kosaka, Y.; Xie, S. P.

2016-12-01

Global-mean surface temperature (GMST) has increased since the 19th century with notable interdecadal accelerations and slowdowns, forming the global-warming "staircase". The last step of this staircase is the surface warming slowdown since the late 1990s, for which the transition of the Interdecadal Pacific Oscillation (IPO) from a positive to negative state has been suggested as the leading mechanism. To examine the role of IPO in the entire warming staircase, a long pacemaker experiment is performed with a coupled climate model where tropical Pacific sea surface temperatures are forced to follow the observed evolution since the late 19th century. The pacemaker experiment successfully reproduces the staircase-like global warming remarkably well since 1900. Without the tropical Pacific effect, the same model produces a continual warming from the 1900s to the 1960 followed by rapid warming. The successful reproduction identifies the tropical Pacific decadal variability as a key pacemaker of the GMST staircase. We further propose a method to remove internal variability from observed GMST changes for real-time monitoring of anthropogenic warming.

Texture Profile and Color Determination on Local and Imported Meat Available in Semarang City, Indonesia

NASA Astrophysics Data System (ADS)

Arifin, Mukh; Ni'matullah Al-Baarri, Ahmad; Etza Setiani, Bhakti; Fazriyati Siregar, Risa

2018-02-01

This study was done for analysing the texture profile and colour performance in local and imported meat in Semarang, Indonesia. Two types of available meat were compared in the hardness, cohesiveness, springiness, adhesiveness and the colour L*a*b* performance. Five fresh beef cut of round meats from local and imported meat were used in this experiments. Data were analysed statistically using T-test. The results showed that local beef exhibit higher in the springiness than imported beef resulting in the remarkable differences. The colour analysis showed that imported beef provided remarkable higher in L* value than local beef. Resulting significant differences among two types of beef. As conclusion, these value might provide the notable of differences among local and imported meat and may give preferences status to the user for further application in meat processing.

Gaze-controlled, computer-assisted communication in Intensive Care Unit: "speaking through the eyes".

PubMed

Maringelli, F; Brienza, N; Scorrano, F; Grasso, F; Gregoretti, C

2013-02-01

The aim of this study was to test the hypothesis that a gaze-controlled communication system (eye tracker, ET) can improve communication processes between completely dysarthric ICU patients and the hospital staff, in three main domains: 1) basic communication processes (i.e., fundamental needs, desire, and wishes); 2) the ability of the medical staff to understand the clinical condition of the patient; and 3) the level of frustration experienced by patient, nurses and physicians. Fifteen fully conscious medical and surgical patients, 8 physicians, and 15 nurses were included in the study. The experimental procedure was composed by three phases: in phase 1 all groups completed the preintervention questionnaire; in phase 2 the ET was introduced and tested as a communication device; in phase 3 all groups completed the postintervention questionnaire. Patients preintervention questionnaires showed remarkable communication deficits, without any group effect. Answers of physicians and nurses were pretty much similar to the one of patients. Postintervention questionnaires showed in all groups a remarkable and statistically significant improvement in different communication domains, as well as a remarkable decrease of anxiety and disphoric thought. Improvement was also reported by physicians and nurses in their ability to understand patient's clinical conditions. Our results show an improvement in the quality of the examined parameters. Better communication processes seem also to lead to improvements in several psychological parameters, namely anxiety and drop-out depression perceived by both patients and medical staff. Further controlled studies are needed to define the ET role in ICU.

Empirical Performance of Cross-Validation With Oracle Methods in a Genomics Context.

PubMed

Martinez, Josue G; Carroll, Raymond J; Müller, Samuel; Sampson, Joshua N; Chatterjee, Nilanjan

2011-11-01

When employing model selection methods with oracle properties such as the smoothly clipped absolute deviation (SCAD) and the Adaptive Lasso, it is typical to estimate the smoothing parameter by m-fold cross-validation, for example, m = 10. In problems where the true regression function is sparse and the signals large, such cross-validation typically works well. However, in regression modeling of genomic studies involving Single Nucleotide Polymorphisms (SNP), the true regression functions, while thought to be sparse, do not have large signals. We demonstrate empirically that in such problems, the number of selected variables using SCAD and the Adaptive Lasso, with 10-fold cross-validation, is a random variable that has considerable and surprising variation. Similar remarks apply to non-oracle methods such as the Lasso. Our study strongly questions the suitability of performing only a single run of m-fold cross-validation with any oracle method, and not just the SCAD and Adaptive Lasso.

Ultrastructural analysis and polymorphisms in Coarazuphium caatinga (Coleoptera: Carabidae: Zuphiini), a new Brazilian troglobitic beetle.

PubMed

Pellegrini, Thais Giovannini; Ferreira, Rodrigo Lopes

2014-02-21

Coarazuphium caatinga sp. n. occurs in limestone caves located in Campo Formoso municipality, in the Brazilian Caatinga (Bahia, Brazil). The new species is close to C. formoso although they are morphologically distinct by the elytra sinuosity, which is more pronounced in C. caatinga; the aedeagus is more tapered at the tip in this last species. Important traits found in C. caatinga are the variable size presented by the eyes, and the remarkable variability of body pigmentation among specimens; both traits do not seem to be correlated. Coarazuphium Gnaspini, P., Vanin, S.A. & Godoy, N.M., 1998, species exhibit advanced troglomorphic characters in comparison to other Brazilian cave beetles, as are increased extra-optic sensory structures, presence of particular sensilla, and sensory and gustatory receptors. These characters are not detected under routine microscopy and thus require ultrastructural methods for their study.

DISTINCT ANTIBODY SPECIES: STRUCTURAL DIFFERENCES CREATING THERAPEUTIC OPPORTUNITIES

PubMed Central

Muyldermans, Serge; Smider, Vaughn V.

2016-01-01

Antibodies have been a remarkably successful class of molecules for binding a large number of antigens in therapeutic, diagnostic, and research applications. Typical antibodies derived from mouse or human sources use the surface formed by complementarity determining regions (CDRs) on the variable regions of the heavy chain/light chain heterodimer, which typically forms a relatively flat binding surface. Alternative species, particularly camelids and bovines, provide a unique paradigm for antigen recognition through novel domains which form the antigen binding paratope. For camelids, heavy chain antibodies bind antigen with only a single heavy chain variable region, in the absence of light chains. In bovines, ultralong CDR-H3 regions form an independently folding minidomain, which protrudes from the surface of the antibody and is diverse in both its sequence and disulfide patterns. The atypical paratopes of camelids and bovines potentially provide the ability to interact with different epitopes, particularly recessed or concave surfaces, compared to traditional antibodies. PMID:26922135

Variable aperture-based ptychographical iterative engine method.

PubMed

Sun, Aihui; Kong, Yan; Meng, Xin; He, Xiaoliang; Du, Ruijun; Jiang, Zhilong; Liu, Fei; Xue, Liang; Wang, Shouyu; Liu, Cheng

2018-02-01

A variable aperture-based ptychographical iterative engine (vaPIE) is demonstrated both numerically and experimentally to reconstruct the sample phase and amplitude rapidly. By adjusting the size of a tiny aperture under the illumination of a parallel light beam to change the illumination on the sample step by step and recording the corresponding diffraction patterns sequentially, both the sample phase and amplitude can be faithfully reconstructed with a modified ptychographical iterative engine (PIE) algorithm. Since many fewer diffraction patterns are required than in common PIE and the shape, the size, and the position of the aperture need not to be known exactly, this proposed vaPIE method remarkably reduces the data acquisition time and makes PIE less dependent on the mechanical accuracy of the translation stage; therefore, the proposed technique can be potentially applied for various scientific researches. (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

Osteogenesis imperfecta in childhood: treatment strategies.

PubMed

Engelbert, R H; Pruijs, H E; Beemer, F A; Helders, P J

1998-12-01

Osteogenesis imperfecta (OI) is a skeletal disorder of remarkable clinical variability characterized by bone fragility, osteopenia, variable degrees of short stature, and progressive skeletal deformities. Additional clinical manifestations such as blue sclerae, dentinogenesis imperfecta, joint laxity, and maturity onset deafness are described in the literature. OI occurs in about 1 in 20,000 births and is caused by quantitative and qualitative defects in the synthesis of collagen I. Depending on the severity of the disease, a large impact on motor development, range of joint motion, muscle strength, and functional ability may occur. Treatment strategies should primarily focus on the improvement of functional ability and the adoption of compensatory strategies, rather than merely improving range of joint motion and muscle strength. Surgical treatment of the extremities may be indicated to stabilize the long bones to optimize functional ability and walking capacity. Surgical treatment of the spine may be indicated in patients with progressive spinal deformity and in those with symptomatic basilar impression.

Cultural variability in Expressed Emotion among families of adolescents with anorexia nervosa.

PubMed

Hoste, Renee Rienecke; Labuschagne, Zandre; Lock, James; Le Grange, Daniel

2012-01-01

To examine the cultural variability in Expressed Emotion (EE) among families of white and ethnic minority adolescents with anorexia nervosa (AN). One-hundred and eighty-nine AN patients and their parents completed the Eating Disorder Examination and the Structured Clinical Family Interview, from which EE ratings were made. No differences were found in the number of white and minority families classified as high EE. White families were higher on warmth (W) and tended to be higher on positive remarks (PR) than minority families. High EE was associated with a longer duration of illness, but was not related to eating disorder pathology. Few differences were found between white and ethnic minority families on the EE dimensions of CC, hostility (H), or EOI. Differences between families on W and PR, however, may have important treatment implications. Copyright © 2010 Wiley Periodicals, Inc.

Analytical study of bound states in graphene nanoribbons and carbon nanotubes: The variable phase method and the relativistic Levinson theorem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miserev, D. S., E-mail: d.miserev@student.unsw.edu.au, E-mail: erazorheader@gmail.com

2016-06-15

The problem of localized states in 1D systems with a relativistic spectrum, namely, graphene stripes and carbon nanotubes, is studied analytically. The bound state as a superposition of two chiral states is completely described by their relative phase, which is the foundation of the variable phase method (VPM) developed herein. Based on our VPM, we formulate and prove the relativistic Levinson theorem. The problem of bound states can be reduced to the analysis of closed trajectories of some vector field. Remarkably, the Levinson theorem appears as the Poincaré index theorem for these closed trajectories. The VPM equation is also reducedmore » to the nonrelativistic and semiclassical limits. The limit of a small momentum p{sub y} of transverse quantization is applicable to an arbitrary integrable potential. In this case, a single confined mode is predicted.« less

Continuous-variable geometric phase and its manipulation for quantum computation in a superconducting circuit.

PubMed

Song, Chao; Zheng, Shi-Biao; Zhang, Pengfei; Xu, Kai; Zhang, Libo; Guo, Qiujiang; Liu, Wuxin; Xu, Da; Deng, Hui; Huang, Keqiang; Zheng, Dongning; Zhu, Xiaobo; Wang, H

2017-10-20

Geometric phase, associated with holonomy transformation in quantum state space, is an important quantum-mechanical effect. Besides fundamental interest, this effect has practical applications, among which geometric quantum computation is a paradigm, where quantum logic operations are realized through geometric phase manipulation that has some intrinsic noise-resilient advantages and may enable simplified implementation of multi-qubit gates compared to the dynamical approach. Here we report observation of a continuous-variable geometric phase and demonstrate a quantum gate protocol based on this phase in a superconducting circuit, where five qubits are controllably coupled to a resonator. Our geometric approach allows for one-step implementation of n-qubit controlled-phase gates, which represents a remarkable advantage compared to gate decomposition methods, where the number of required steps dramatically increases with n. Following this approach, we realize these gates with n up to 4, verifying the high efficiency of this geometric manipulation for quantum computation.

Synthesis of 4-aminophenyl substituted indole derivatives for the instrumental analysis and molecular docking evaluation studies

NASA Astrophysics Data System (ADS)

Singh, Navneet; Kumar, Keshav

2017-07-01

The Indole has been known to maintain celebrity status since so many decades and has been a centre point at the spectrum of pharmacological research. The present work stimulates an idea of generating a pool of library of lead compounds. The data collected can be used for the mapping of biologically active compounds. The reported derivatives of 4-aminophenyl substituted Indole were prepared by the methods of Fischer Indole synthesis and Vilsemeier reaction followed by screening for instrumental analysis and molecular docking studies. The synthesized compounds 4-(1-(2-phenylhydrazono)ethyl)aniline, 1, 4-(1H-indol-2-yl)aniline, 2 and 2-(4-aminophenyl)-1H-indole-3-carbaldehyde, 3 were found to have remarkable yield and instrumental data analysis and also showed remarkable docked characteristic. The molecular docking studies revealed that ligand (amino acids) of comp. 1, 2 and 3 had been docked successfully on the binding site of the 3JUS protein selected from PDB with H bonding. The molecular docking data showed that compound 1, would possess remarkable biological activity and compd. 2 and 3 would possess mild to moderate biological activity. Thus this research work paves the way to synthesize new derivatives and thus to develop new compounds in future with accurate prediction.

Studies on mimicry of naturally occurring annonaceous acetogenins: non-THF analogues leading to remarkable selective cytotoxicity against human tumor cells.

PubMed

Zeng, Bu-Bing; Wu, Yikang; Jiang, Sheng; Yu, Qian; Yao, Zhu-Jun; Liu, Zhong-Hai; Li, Hong-Yan; Li, Yan; Chen, Xiao-Guang; Wu, Yu-Lin

2003-01-03

A class of structurally simplified analogues of the naturally occurring annonaceous acetogenins were developed, amongst which some non-THF analogues showed remarkable cytotoxicities against tumor cell lines, as well as good selectivity between human tumor cells and normal cells. The synthetic routes were significantly shortened because of the removal of the chiral centers bearing the THF rings on the natural templates. This simplification also provides access to the parallel synthesis of these mimics by a combinatorial strategy. The remaining stereogenic centers at the positions alpha to the ethereal links were introduced by the Chiron approach from the easily accessible chiral building blocks 6a and/or 6b, made in turn from L-ascorbic acid or D-mannitol, while the one in the butenolide segment was taken from L-lactate. All four diastereomeric non-THF analogues 2a-2d showed remarkable activity against the HCT-8 cell line, and better differentiation was found when testing against the HT-29 cell line. It was also discovered that both the butenolide and ethylene glycol subunits play essential roles in the cytotoxicities against tumor cell lines, while the 10-substituted hydroxy group and the absolute configuration of methyl group at the butenolide moiety are less important for their activity.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsapatsaris, N., E-mail: nikolaos.tsapatsaris@esss.se, E-mail: ruep.lechner@gmail.com, E-mail: bordallo@nbi.ku.dk; Bordallo, H. N., E-mail: nikolaos.tsapatsaris@esss.se, E-mail: ruep.lechner@gmail.com, E-mail: bordallo@nbi.ku.dk; European Spallation Source ERIC, Tunavägen 24, 22100 Lund

In this work, we present the conceptual design of the backscattering time-of-flight spectrometer MIRACLES approved for construction at the long-pulse European Spallation Source (ESS). MIRACLES’s unparalleled combination of variable resolution, high flux, extended energy, and momentum transfer (0.2–6 Å{sup −1}) ranges will open new avenues for neutron backscattering spectroscopy. Its remarkable flexibility can be attributed to 3 key elements: the long-pulse time structure and low repetition rate of the ESS neutron source, the chopper cascade that tailors the moderator pulse in the primary part of the spectrometer, and the bent Si(111) analyzer crystals arranged in a near-backscattering geometry in themore » secondary part of the spectrometer. Analytical calculations combined with instrument Monte-Carlo simulations show that the instrument will provide a variable elastic energy resolution, δ(ħ ω), between 2 and 32 μeV, when using a wavelength of λ ≈ 6.267 Å (Si(111)-reflection), with an energy transfer range, ħ ω, centered at the elastic line from −600 to +600 μeV. In addition, when selecting λ ≈ 2.08 Å (i.e., the Si(333)-reflection), δ(ħ ω) can be relaxed to 300 μeV and ħ ω from about 10 meV in energy gain to ca −40 meV in energy loss. Finally, the dynamic wavelength range of MIRACLES, approximately 1.8 Å, can be shifted within the interval of 2–20 Å to allow the measurement of low-energy inelastic excitations.« less

Tectonic controls on the morphodynamics of the Brahmaputra River system in the upper Assam valley, India

NASA Astrophysics Data System (ADS)

Lahiri, Siddhartha K.; Sinha, Rajiv

2012-10-01

The Brahmaputra is one of the largest tropical rivers of the world and is located in an area of high structural instability as evidenced from the presence of a large number of earthquakes in the Himalayan catchment through which it flows. Syntectonic evidence of changes in the morphodynamics is difficult to identify for the large rivers. Nevertheless, we note that the Brahmaputra River has become astonishingly large in planform in a historical timescale. Reconstruction of planform changes over a period of 90 years in the upper reaches of the Assam valley shows that the 240-km-long channel belt is widening all along its course in the region. From the average width of 9.74 km in 1915, the channel belt has widened to the average width of 14.03 km in 2005 (44% widening), and in certain reaches the average widening is as high as 250%. However, the bank line shift is not symmetric along both banks. Further, the planform characteristics of the Brahmaputra River reveal significant spatial and temporal variability from upstream to downstream reaches, and we attribute this variability to tectonogeomorphic zonation of the river based on subsurface configuration and channel slope. Further, the tributaries joining the northern and southern banks of the Brahmaputra differ remarkably in terms of river dynamics, and this is attributed to the differences in tectonic regimes of the Himalaya in the north and the Naga Patkai hills in the south.

Variability of basin-scale terrestrial water storage from a novel application of the water budget equation: the Amazon and the Mississippi

NASA Astrophysics Data System (ADS)

Yoon, J.; Zeng, N.; Mariotti, A.; Swenson, S.

2007-12-01

In an approach termed the P-E-R (or simply PER) method, we apply the basin water budget equation to diagnose the long-term variability of the total terrestrial water storage (TWS). The key input variables are observed precipitation (P) and runoff (R), and estimated evaporation (E). Unlike typical offline land-surface model estimate where only atmospheric variables are used as input, the direct use of observed runoff in the PER method imposes an important constraint on the diagnosed TWS. Although there lack basin-scale observations of evaporation, the tendency of E to have significantly less variability than the difference between precipitation and runoff (P-R) minimizes the uncertainties originating from estimated evaporation. Compared to the more traditional method using atmospheric moisture convergence (MC) minus R (MCR method), the use of observed precipitation in PER method is expected to lead to general improvement, especially in regions atmospheric radiosonde data are too sparse to constrain the atmospheric model analyzed MC such as in the remote tropics. TWS was diagnosed using the PER method for the Amazon (1970-2006) and the Mississippi Basin (1928-2006), and compared with MCR method, land-surface model and reanalyses, and NASA's GRACE satellite gravity data. The seasonal cycle of diagnosed TWS over the Amazon is about 300 mm. The interannual TWS variability in these two basins are 100-200 mm, but multi-dacadal changes can be as large as 600-800 mm. Major droughts such as the Dust Bowl period had large impact with water storage depleted by 500 mm over a decade. Within the short period 2003-2006 when GRACE data was available, PER and GRACE show good agreement both for seasonal cycle and interannual variability, providing potential to cross-validate each other. In contrast, land-surface model results are significantly smaller than PER and GRACE, especially towards longer timescales. While we currently lack independent means to verify these long-term changes, simple error analysis using 3 precipitation datasets and 3 evaporation estimates suggest that the multi-decadal amplitude can be uncertain up to a factor of 2, while the agreement is high on interannual timescales. The large TWS variability implies the remarkable capacity of land-surface in storing and taking up water that may be under-represented in models. The results also suggest the existence of water storage memories on multi-year time scales, significantly longer than typically assumed seasonal timescales associated with surface soil moisture.

OV Bootis: Forty Nights Of World-Wide Photometry

NASA Astrophysics Data System (ADS)

Patterson, Joseph; de Miguel, Enrique; Barret, Douglas; Brincat, Stephen; Boardman, James, Jr.; Buczynski, Denis; Campbell, Tut; Cejudo, David; Cook, Lew; Cook, Michael J.; Collins, Donald; Cooney, Walt; Dubois, Franky; Dvorak, Shawn; Halpern, Jules P.; Kroes, Anthony J.; Lemay, Damien; Licchelli, Domenico; Mankel, Dylan; Marshall, Matt; Novak, Rudolf; Oksanen, Arto; Roberts, George; Seargeant, Jim; Sears, Huei; Silcox, Austin; Slauson, Douglas; Stone, Geoff; Thorstensen, J. R.; Ulowetz, Joe; Vanmunster, Tonny; Wallgren, John; Wood, Matt

2017-06-01

Among the 1000 known cataclysmic variables, only one appears to belong to the "Galactic halo" - the Population II stars. We report round-the-world photometry of this star (OV Boo) during March-April 2017, when it staged its first certified dwarf-nova outburst. The star is remarkable for its short binary period (66 minutes), high proper motion, metal-poor composition, substellar secondary, sharp white-dwarf eclipses, and nonradial pulsations. Something for everybody...... and it even had the good manners to erupt in northern springtime, when it transits near local midnight. Move over, SS Cyg and WZ Sge; there's a new celebrity in town!

What's Going on Around BN

NASA Technical Reports Server (NTRS)

Erickson, Edwin; Colgan, S. W. J.; Schultz, A. S. B.; Simpson, J. P.; Burton, M. G.; Kaufman, M. J.; Young, E. T.; Stolovy, S.

2005-01-01

The Becklin-Neugebauer object, discovered in observations made by Eric Becklin as a graduate student, is the brightest mid-infrared source outside the solar system, and a beacon in the nearest region of massive star formation. Using NICMOS on HST, we have obtained near infrared photometric, spectroscopic, and polarimetric images of the region immediately around BN. These images, with resolutions < -0.2", reveal remarkable morphologies, shock details, new young stellar objects, faint stars with variable intensities, and outflow features. We will summarize these results and inferences regarding the shock properties, illuminating sources of the nebulosity, and IRc sources near BN.

In vitro storage of cedar shoot cultures under minimal growth conditions.

PubMed

Renau-Morata, Begoña; Arrillaga, Isabel; Segura, Juan

2006-07-01

We developed procedures for slow-growth storage of Cedrus atlantica and Cedrus libani microcuttings of juvenile and adult origin, noting factors favouring the extension of subculture intervals. Microcuttings could be stored effectively up to 6 months at 4 degrees C and reduced light intensity, provided that they were grown on a diluted modified MS medium. The addition of 6% mannitol to the storage media affected negatively survival and multiplication capacity of the cultures. The slow-growth storage conditions used in our experiments did not induce remarkable effects on both RAPD variability and average DNA methylation in the species.

Use of SAR imagery and other remotely-sensed data in deriving ice information during a severe ice event on the Grand Banks (Newfoundland)

NASA Technical Reports Server (NTRS)

Carsey, F. D.; Argus, S. D.

1988-01-01

Image data from synthetic aperture radar (SAR) are used to observe an ice compaction event off the East Coast of Newfoundland in spring, 1987. The information developed from sequential SAR observations is shown to do a remarkably effective job of describing the ice conditions; the difficult variable is the ice thickness which is found to be surprisingly large (2 to 4 times the thickness predictable from thermodynamic growth alone). It may be possible to model the ice thickness using SAR-derived ice motion.

Changing Returns to Education in Spain During the 1980s.

ERIC Educational Resources Information Center

Vila, Luis-Eduardo; Mora, Jose-Gines

1998-01-01

Presents evidence on returns to education for Spanish employees during the 1980s, a period of remarkable structural transformation. Results show a declining payoff to education between 1981 and 1991 for lower and intermediate educational levels. Higher education does not show a reduction in return. Earnings inequality by gender declined noticeably…

Hydroclimate variability in NE Brazil over the last 2K

NASA Astrophysics Data System (ADS)

Giselle, Utida; Ioanna, Bouloubassi; Francisco, Cruz; Enno, Schefuβ; Abdel, Sifeddine; Vincent, Klein; Johan, Etourneau; Renata, Zocatelli; André, Zular; Hai, Cheng; Laurence, Edwards R.

2016-04-01

Precipitation associated with the South American Summer Monsoon (SASM) and the Intertropical Convergence Zone (ITCZ) supplies more than 70% of tropical South America's annual precipitation and is fundamental in sustaining the water regime for regional socioeconomic activities. Motivated by the fact that the greatest uncertainty in model projections of future precipitation trends lies in the tropics, and particularly in South America, a number of recent proxy and modeling studies have aimed at understanding SASM spatiotemporal variability regarding its dynamics, driving mechanisms and teleconnections. Exact reconstructions of past meridional ITCZ displacements (timing, sign, amplitude), however, are currently lacking, mainly because of the paucity of suited high-resolution archives. This restricts our ability to assess regional rainfall variability at decadal to centennial timescales, especially in the hydroclimatic-sensitive semi-arid Nordeste, needed to understand the interactions between SASM and ITCZ and to evaluate the impact of Pacific-Atlantic climate interactions on the regional rainfall variability at decadal/multi-decadal scale. Here we present two new and complementary high-resolution records of past precipitation over the last 2K from the north area of Nordeste, an area ideally located to track fluctuations in the southernmost edge of ITCZ movement. We present a new δO18 record from a local speleothem and combine it, for the first time, with δD analyses of wax lipids in well-dated sediments from a nearby lake. The two independent records show a remarkable similarity and are characterized by strong decadal to multidecadal variability as well as century-scale changes. The period 250-450 yrs CE appears as the wettest phase over the last 2K, while the Medieval Climate Anomaly (MCA) is characterized by extremely dry conditions. Following the MCA, the Little Ice Age (LIA) is a relatively wetter phase. The data document fluctuations of southern meridional ITCZ movements during the last millennium that compare well with available records of fluctuations in northern ITCZ extension (Cariaco Basin). Comparisons to proxy records from tropical South America regions affected by the SASM and the South America Convergence Zone (SACZ) allow evaluating the SAMS/SACZ-ITCZ linkages. Furthermore, the data are discussed in terms of the role of the Atlantic and Pacific modes of variability in modulating regional hydroclimate.

Interannual Variability in Global Dust Storm Initiation on Mars from a GCM with Orbit-Spin Coupling and Active Dust Lifting

NASA Astrophysics Data System (ADS)

Mischna, M.; Shirley, J. H.; Newman, C. E.

2016-12-01

To first order, the occurrence and interannual variability of global dust storms (GDS) on Mars is attributable to two factors: the annual cycle of solar insolation (which delineates a specific `dust storm season'), and the changing spatial distribution and availability of dust at the surface. Recent work has now found a remarkable correspondence between the occurrence of GDS on Mars and years in which the orbital angular momentum of Mars is increasing during the dust storm season. A previously undefined acceleration term `couples' this orbital motion to the rotational motion of the planet and atmosphere, and small but persistent atmospheric accelerations (so-called `coupling term accelerations,' or CTA) change the atmospheric circulation in such a way as to seemingly be favorable to storm development. This becomes a third factor, then, that may regulate the occurrence and variability of GDS. Our prior work with the MarsWRF general circulation model (GCM) was performed either with no atmospheric dust, or with simplified, prescribed dust distributions, and illustrated the dual roles of both insolation and CTA on GDS variability. Recent advances in the MarsWRF GCM dust prescription can now tackle the remaining unaddressed factor: the role of dust availability in controlling the initiation of GDS. Simulations with both infinite and finite global sources of dust have been performed. For a prescribed dust lifting threshold, surface dust is removed from the surface, preferentially from locations with larger surface stress values, transported in the atmosphere and deposited at a later time. Compared to simulations without CTA, those with CTA show more realism in the variability of timing and magnitude of atmospheric dustiness during the dust storm season. For infinite surface dust, the primary dust lifting (peak wind stress) regions are spatially restricted, and year-to-year changes are largely due to variations in the CTA at these few locations. By contrast, in simulations with finite surface dust, the peak stress regions are rapidly exhausted, leading to a far greater distribution of primary dust lifting regions; hence, variations in the CTA over a wider area contribute to the interannual variability of GDS. Results from our suite of simulations will be shown, vis-à-vis the historical record of GDS on Mars.

Multi-wavelength Observations of Accreting Compact Objects

NASA Astrophysics Data System (ADS)

Hernandez Santisteban, Juan Venancio

2016-11-01

The study of compact binaries invokes core astrophysical concepts ranging from stellar and sub-stellar atmospheres and interiors, stellar and binary evolution to physics of accretion. All of these systems are hosts to a compact object a white dwarf, neutron star or black hole ???? which produces a wide variety of exotic and energetic phenomena across the full electromagnetic spectrum. In this thesis, I will make use of multi-wavelength observations ranging from far-ultraviolet to nearinfrared in order to investigate two main topics: a) the late evolution of cataclysmic variables, and b) the accreting state of transitional millisecond pulsars. Firstly, I analyse the Very Large Telescope X-Shooter time-resolved spectroscopy of the short orbital period cataclysmic variable, SDSS J1433+1011, in Chapter 2. The wide wavelength coverage allowed me to perform a detailed characterisation of the system, as well as a direct mass measurement of the brown dwarf companion. I show that the donor in SDSS J1433+1011 successfully transitioned from the stellar to sub-stellar regime, as predicted by evolutionary models. Further light-curve modelling allowed me to show that a low albedo as well as a low heat circulation efficiency is present in the atmosphere of the sub-stellar donor. In Chapter 3, I analyse data from large synoptic surveys, such as SDSS and PTF, to search for the predicted population of dead cataclysmic variables. Following the non-detection of dead CVs, I was able to estimate the space density (?0 < 2?10????5 pc????3) of this hidden population via a Monte Carlo simulation of the Galactic CV population. In Chapter 4, I present Hubble Space Telescope ultraviolet observations of the transitional millisecond pulsar PSR J1023+0038, during its latest accretion state. In combination with optical and near-infrared data, I show that a standard accretion disc does not reach the magnetosphere of the neutron star. Instead, the overall spectrum is consistent with a truncated disc at ? 2:3 ? 109 cm away from the compact object. Furthermore, the ultraviolet data shares remarkable similarities with the only accreting white dwarf in a propeller regime, AE Aqr. Finally, I summarise my results in Chapter 5 and provide future lines of research in accreting compact binaries based on this work.

Impacts of the Variability of Ice Types on the Decline of the Arctic Perennial Sea Ice Cover

NASA Technical Reports Server (NTRS)

Comiso, Josefino C.

2005-01-01

The observed rapid decline in the Arctic perennial ice cover is one of the most remarkable signal of change in the Arctic region. Updated data now show an even higher rate of decline of 9.8% per decade than the previous report of 8.9% per decade mainly because of abnormally low values in the last 4 years. To gain insights into this decline, the variability of the second year ice, which is the relatively thin component of the perennial ice cover, and other ice types is studied. The perennial ice cover in the 1990s was observed to be highly variable which might have led to higher production of second year ice and may in part explain the observed ice thinning during the period and triggered further decline. The passive microwave signature of second year ice is also studied and results show that while the signature is different from that of the older multiyear ice, it is surprisingly more similar to that of first year ice. This in part explains why previous estimates of the area of multiyear ice during the winter period are considerably lower than the area of the perennial ice cover during the preceding summer. Four distinct clusters representing radiometrically different types have been identified using multi-channel cluster analysis of passive microwave data. Data from two of these clusters, postulated to come from second year and older multiyear ice regions are also shown to have average thicknesses of 2.4 and 4.1 m, respectively, indicating that the passive microwave data may contain some ice thickness information that can be utilized for mass balance studies. The yearly anomaly maps indicate high gains of first year ice cover in the Arctic during the last decade which means higher production of second year ice and fraction of this type in the declining perennial ice cover. While not the only cause, the rapid decline in the perennial ice cover is in part caused by the increasing fractional component of the thinner second year ice cover that is very vulnerable to total melt due to warming in the Arctic, especially in spring.

Functional proteomic analyses of Bothrops atrox venom reveals phenotypes associated with habitat variation in the Amazon.

PubMed

Sousa, Leijiane F; Portes-Junior, José A; Nicolau, Carolina A; Bernardoni, Juliana L; Nishiyama, Milton Y; Amazonas, Diana R; Freitas-de-Sousa, Luciana A; Mourão, Rosa Hv; Chalkidis, Hipócrates M; Valente, Richard H; Moura-da-Silva, Ana M

2017-04-21

Venom variability is commonly reported for venomous snakes including Bothrops atrox. Here, we compared the composition of venoms from B. atrox snakes collected at Amazonian conserved habitats (terra-firme upland forest and várzea) and human modified areas (pasture and degraded areas). Venom samples were submitted to shotgun proteomic analysis as a whole or compared after fractionation by reversed-phase chromatography. Whole venom proteomes revealed a similar composition among the venoms with predominance of SVMPs, CTLs, and SVSPs and intermediate amounts of PLA 2 s and LAAOs. However, when distribution of particular isoforms was analyzed by either method, the venom from várzea snakes showed a decrease in hemorrhagic SVMPs and an increase in SVSPs, and procoagulant SVMPs and PLA 2 s. These differences were validated by experimental approaches including both enzymatic and in vivo assays, and indicated restrictions in respect to antivenom efficacy to variable components. Thus, proteomic analysis at the isoform level combined to in silico prediction of functional properties may indicate venom biological activity. These results also suggest that the prevalence of functionally distinct isoforms contributes to the variability of the venoms and could reflect the adaptation of B. atrox to distinct prey communities in different Amazon habitats. In this report, we compared isoforms present in venoms from snakes collected at different Amazonian habitats. By means of a species venom gland transcriptome and the in silico functional prediction of each isoform, we were able to predict the principal venom activities in vitro and in animal models. We also showed remarkable differences in the venom pools from snakes collected at the floodplain (várzea habitat) compared to other habitats. Not only was this venom less hemorrhagic and more procoagulant, when compared to the venom pools from the other three habitats studied, but also this enhanced procoagulant activity was not efficiently neutralized by Bothrops antivenom. Thus, using a functional proteomic approach, we highlighted intraspecific differences in B. atrox venom that could impact both in the ecology of snakes but also in the treatment of snake bite patients in the region. Copyright © 2017 Elsevier B.V. All rights reserved.

Molybdenum distributions and variability in drinking water from England and Wales.

PubMed

Smedley, P L; Cooper, D M; Lapworth, D J

2014-10-01

An investigation has been carried out of molybdenum in drinking water from a selection of public supply sources and domestic taps across England and Wales. This was to assess concentrations in relation to the World Health Organization (WHO) health-based value for Mo in drinking water of 70 μg/l and the decision to remove the element from the list of formal guideline values. Samples of treated drinking water from 12 water supply works were monitored up to four times over an 18-month period, and 24 domestic taps were sampled from three of their supply areas. Significant (p < 0.05) differences were apparent in Mo concentration between sources. Highest concentrations were derived from groundwater from a sulphide-mineralised catchment, although concentrations were only 1.5 μg/l. Temporal variability within sites was small, and no seasonal effects (p > 0.05) were detected. Tap water samples collected from three towns (North Wales, the English Midlands, and South East England) supplied uniquely by upland reservoir water, river water, and Chalk groundwater, respectively, also showed a remarkable uniformity in Mo concentrations at each location. Within each, the variability was very small between houses (old and new), between pre-flush and post-flush samples, and between the tap water and respective source water samples. The results indicate that water distribution pipework has a negligible effect on supplied tap water Mo concentrations. The findings contrast with those for Cu, Zn, Ni, Pb, and Cd, which showed significant differences (p < 0.05) in concentrations between pre-flush and post-flush tap water samples. In two pre-flush samples, concentrations of Ni or Pb were above drinking water limits, although in all cases, post-flush waters were compliant. The high concentrations, most likely derived from metal pipework in the domestic distribution system, accumulated during overnight stagnation. The concentrations of Mo observed in British drinking water, in all cases less than 2 μg/l, were more than an order of magnitude below the WHO health-based value and suggest that Mo is unlikely to pose a significant health or water supply problem in England and Wales.

The spatial variable glacier mass loss over the southeast Tibet Plateau and the climate cause analyses

NASA Astrophysics Data System (ADS)

Ke, L.; Ding, X.; Song, C.; Sheng, Y.

2016-12-01

Temperate glaciers can be highly sensitive to global climate change due to relatively humid and warm local climate. Numerous temperate glaciers are distributed in the southeastern Tibet Plateau (SETP) and their changes are still poorly represented. Based on a latest glacier inventory and ICESat altimetry measurements, we examine the spatial heterogeneity of glacier change in the SETP (including the central and eastern Nyainqêntanglha ranges) and further analyze its relation with climate change by using station-based and gridded meteorological data. Our results show that SETP glaciers experienced drastic surface lowering at about -0.84±0.26 m a-1 on average over 2003-2008. Debris-covered ice thinned at an average rate of -1.13±0.32 m a-1, in comparison with -0.92±0.17 m a-1 over the debris-free ice areas. The thinning rate is the strongest in the southeastern sub-region (up to -1.24 m a-1 ) and moderate ( -0.45 m a-1 ) in the central and northwestern parts, which is in general agreement with the pattern of surface mass changes based on the GRACE gravimetry observation. Long-term climate data at weather stations show that, in comparison with the period of 1992-2002, mean temperature increased by 0.46 °C - 0.59 °C in the recent decade (2003-2013); while the change of summer precipitation exhibited remarkably spatial variability, following a southeast-northwest contrasting pattern (decreasing by over 10% in the southeast, to stable level in the central region, and increment up to 10% in the northwest). This spatially variable precipitation change is consistent with results from CN05 grid data and ERA re-analysis data, and agrees well with the spatial pattern of glacier surface elevation changes. The results suggest that overall negative glacier mass balances in SETP are governed by temperature rising, while the different precipitation change could contribute to inconsistent glacier thinning rates. The spatial pattern of precipitation decrease and mass loss might be tele-connected with the dynamics of the Indian summer monsoon.

Trends and variability of atmospheric PM2.5 and PM10-2.5 concentration in the Po Valley, Italy

NASA Astrophysics Data System (ADS)

Bigi, Alessandro; Ghermandi, Grazia

2016-12-01

The Po Valley is one of the largest European regions with a remarkably high concentration level of atmospheric pollutants, both for particulate and gaseous compounds. In the last decade stringent regulations on air quality standards and on anthropogenic emissions have been set by the European Commission, including also for PM2.5 and its main components since 2008. These regulations have led to an overall improvement in air quality across Europe, including the Po Valley and specifically PM10, as shown in a previous study by Bigi and Ghermandi (2014). In order to assess the trend and variability in PM2.5 in the Po Valley and its role in the decrease in PM10, we analysed daily gravimetric equivalent concentration of PM2.5 and of PM10-2.5 at 44 and 15 sites respectively across the Po Valley. The duration of the times series investigated in this work ranges from 7 to 10 years. For both PM sizes, the trend in deseasonalized monthly means, annual quantiles and in monthly frequency distribution was estimated: this showed a significant decreasing trend at several sites for both size fractions and mostly occurring in winter. All series were tested for a significant weekly periodicity (a proxy to estimate the impact of primary anthropogenic emissions), yielding positive results for summer PM2.5 and for summer and winter PM10-2.5. Hierarchical cluster analysis showed moderate variability in PM2.5 across the valley, with two to three main clusters, dividing the area in western, eastern and southern/Apennines foothill sectors. The trend in atmospheric concentration was compared with the time series of local emissions, vehicular fleet details and fuel sales, suggesting that the decrease in PM2.5 and in PM10 originates from a drop both in primary and in precursors of secondary inorganic aerosol emissions, largely ascribed to vehicular traffic. Potentially, the increase in biomass burning emissions in winter and the modest decrease in NH3 weaken an otherwise even larger drop in atmospheric concentrations.

Reliability Coupled Sensitivity Based Design Approach for Gravity Retaining Walls

NASA Astrophysics Data System (ADS)

Guha Ray, A.; Baidya, D. K.

2012-09-01

Sensitivity analysis involving different random variables and different potential failure modes of a gravity retaining wall focuses on the fact that high sensitivity of a particular variable on a particular mode of failure does not necessarily imply a remarkable contribution to the overall failure probability. The present paper aims at identifying a probabilistic risk factor ( R f ) for each random variable based on the combined effects of failure probability ( P f ) of each mode of failure of a gravity retaining wall and sensitivity of each of the random variables on these failure modes. P f is calculated by Monte Carlo simulation and sensitivity analysis of each random variable is carried out by F-test analysis. The structure, redesigned by modifying the original random variables with the risk factors, is safe against all the variations of random variables. It is observed that R f for friction angle of backfill soil ( φ 1 ) increases and cohesion of foundation soil ( c 2 ) decreases with an increase of variation of φ 1 , while R f for unit weights ( γ 1 and γ 2 ) for both soil and friction angle of foundation soil ( φ 2 ) remains almost constant for variation of soil properties. The results compared well with some of the existing deterministic and probabilistic methods and found to be cost-effective. It is seen that if variation of φ 1 remains within 5 %, significant reduction in cross-sectional area can be achieved. But if the variation is more than 7-8 %, the structure needs to be modified. Finally design guidelines for different wall dimensions, based on the present approach, are proposed.

Trends and variability of the atmosphere–ocean turbulent heat flux in the extratropical Southern Hemisphere

PubMed Central

Herman, Agnieszka

2015-01-01

Ocean–atmosphere interactions are complex and extend over a wide range of temporal and spatial scales. Among the key components of these interactions is the ocean–atmosphere (latent and sensible) turbulent heat flux (THF). Here, based on daily optimally-interpolated data from the extratropical Southern Hemisphere (south of 30°S) from a period 1985–2013, we analyze short-term variability and trends in THF and variables influencing it. It is shown that, in spite of climate-change-related positive trends in surface wind speeds over large parts of the Southern Ocean, the range of the THF variability has been decreasing due to decreasing air–water temperature and humidity differences. Occurrence frequency of very large heat flux events decreased accordingly. Remarkably, spectral analysis of the THF data reveals, in certain regions, robust periodicity at frequencies 0.03–0.04 day−1, corresponding exactly to frequencies of the baroclinic annular mode (BAM). Finally, it is shown that the THF is correlated with the position of the major fronts in sections of the Antarctic Circumpolar Current where the fronts are not constrained by the bottom topography and can adjust their position to the atmospheric and oceanic forcing, suggesting differential response of various sections of the Southern Ocean to the changing atmospheric forcing. PMID:26449323

Genomic evolution of the ascomycetous yeasts

USDA-ARS?s Scientific Manuscript database

Yeasts are important for industrial and biotechnological processes and show remarkable metabolic and phylogenetic diversity despite morphological similarities. We have sequenced the genomes of 16 ascomycete yeasts of taxonomic and industrial importance including members of Saccharomycotina and Taphr...

Floor of Baldet Crater

NASA Image and Video Library

2002-06-17

This NASA Mars Odyssey image shows a remarkable array of dunes on the floor of a large impact crater named Baldet. Many of the dunes in this region are isolated features with large, sand-free interdune surfaces between the individual dunes.

Two Faces of Pluto July 1

NASA Image and Video Library

2015-12-31

Pluto shows two remarkably different sides in these color images of the planet and its largest moon, Charon, taken by NASA New Horizons on June 25 and June 27, 2015. http://photojournal.jpl.nasa.gov/catalog/PIA20292

Ripple Trap

NASA Image and Video Library

2006-04-03

This Mars Global Surveyor MGS Mars Orbiter Camera MOC image shows the margin of a lava flow on a cratered plain in the Athabasca Vallis region of Mars. Remarkably, the cratered plain in this scene is essentially free of bright, windblown ripples

How to move with no rigid skeleton? The octopus has the answers.

PubMed

Yekutieli, Yoram; Sumbre, German; Flash, Tamar; Hochner, Binyamin

2002-12-01

The octopus is amazingly flexible and shows exceptional control and coordination in all its movements. It seems remarkable to us skeletal creatures that the octopus achieves all this without a single bone.

Allotropes of Phosphorus with Remarkable Stability and Intrinsic Piezoelectricity

NASA Astrophysics Data System (ADS)

Li, Zhenqing; He, Chaoyu; Ouyang, Tao; Zhang, Chunxiao; Tang, Chao; Römer, Rudolf A.; Zhong, Jianxin

2018-04-01

We construct a class of two-dimensional (2D) phosphorus allotropes by assembling a previously proposed ultrathin metastable phosphorus nanotube into planar structures in different stacking orientations. Based on first-principles methods, the structures, stabilities, and fundamental electronic properties of these allotropes are systematically investigated. Our results show that these 2D van der Waals phosphorene allotropes possess remarkable stabilities due to the strong intertube van der Waals interactions, which cause an energy release of about 30 - 70 meV /atom , depending on their stacking details. Most of them are confirmed to be energetically more favorable than the experimentally viable α -P and β -P . Three of them, showing a relatively higher probability of being synthesized in the future, are further confirmed to be dynamically stable semiconductors with strain-tunable band gaps and intrinsic piezoelectricity, which may have potential applications in nanosized sensors, piezotronics, and energy harvesting in portable electronic nanodevices.

Smoking in movies: impact on adolescent smoking.

PubMed

Sargent, James D

2005-06-01

This article examines the evidence that supports an association between seeing smoking depictions in movies and adolescent smoking. The portrayal of tobacco use is common in movies and often is modeled by stars, who, from a social influences standpoint, should be powerful behavior change agents. The results of studies that assess audience responses to tobacco portrayal in movies are remarkably consistent in showing a moderate to strong association between seeing movie smoking and more positive attitudes toward smoking and adolescent smoking initiation. The two published longitudinal studies show an independent link between exposure to movie smoking at baseline and initiation in the future, with estimates of the effect size being remarkably consistent with their cross-sectional counterparts. Pediatricians should support public health campaigns to pressure the movie industry to voluntarily reduce smoking in movies and encourage parents to adhere to the Motion Picture Ratings System to reduce adolescent exposure to this powerful social influence to smoke.

Semiclassical evaluation of quantum fidelity

NASA Astrophysics Data System (ADS)

Vaníček, Jiří; Heller, Eric J.

2003-11-01

We present a numerically feasible semiclassical (SC) method to evaluate quantum fidelity decay (Loschmidt echo) in a classically chaotic system. It was thought that such evaluation would be intractable, but instead we show that a uniform SC expression not only is tractable but it also gives remarkably accurate numerical results for the standard map in both the Fermi-golden-rule and Lyapunov regimes. Because it allows Monte Carlo evaluation, the uniform expression is accurate at times when there are 1070 semiclassical contributions. Remarkably, it also explicitly contains the “building blocks” of analytical theories of recent literature, and thus permits a direct test of the approximations made by other authors in these regimes, rather than an a posteriori comparison with numerical results. We explain in more detail the extended validity of the classical perturbation approximation and show that within this approximation, the so-called “diagonal approximation” is automatic and does not require ensemble averaging.

Measurement of the cariogenicity of snacks using a radioisotope PAHA disc.

PubMed

Lee, Eun-Jung; Yun, Hye-Kyoung; Hwang, In-Kyeong; Bae, Kwang-Hak; Jin, Bo-Hyoung; Paik, Dai-il

2012-06-01

This study aimed to establish a method for measuring the cariogenic potential of foods with high reproducibility in vitro. Streptococcus mutans (S. mutans) was incubated in test foods with radioisotope polyacrylamide hydroxyapatite (PAHA) for 150 min at 37 °C. Then, the amount of radioisotope (32)P released from PAHA was measured using a liquid scintillation counter and scanning electron microscopy (SEM). The radioisotope PAHA discs that were soaked in 10% sucrose solutions had a high cariogenic potential and showed a remarkably demineralized surface (p < 0.05). The radioisotope PAHA disc that was incubated with snacks that had a high cariogenic potential showed a remarkably demineralized surface via SEM. Candy had a relatively high cariogenic potential, whereas xylitol gum had a relatively low potential. The cariogenicity of snacks can easily be evaluated by measuring the amount of (32)P released from radioisotope PAHA discs. Copyright © 2011 Elsevier Ltd. All rights reserved.

Incidence of diarrhea with antibiotics and the increase of clostridia in rabbits.

PubMed

Hara-Kudo, Y; Morishita, Y; Nagaoka, Y; Kasuga, F; Kumagai, S

1996-12-01

Rabbits were treated with a single intravenous injection of various antibiotics. More than 40 per cent of the animals showed diarrhea after being treated with sulbactam/cefoperazone, cefmetazole, clindamycin, piperacillin or aspoxicillin. Clostridium difficile was isolated from sulbactam/cefoperazone-treated diarrheic rabbits, with their cecal contents showing positive reaction in a latex agglutination test for C. difficile enterotoxin. However, 27 cefmetazole-induced diarrheic cases were not associated with C. difficile. Other enteropathogenic bacteria, such as Campylobacter spp., Bacillus cereus, enteropathogenic Escherichia coli, coagulase positive Staphylococcus aureus, Salmonella spp., Vibrio spp., Clostridium perfringens and Clostridium spiroforme, were not isolated from either of diarrheic rabbit. However, the counts of clostridia remarkably increased in the intestine of cefmetazole-associated diarrheic rabbits. This was ascribed to the overgrowth of Clostridium innocuum and Clostridium sporogenes. There were no remarkable differences in changes in other bacterial population between diarrheic and non-diarrheic rabbits.

Termitarium-Inhabiting Bacillus spp. Enhanced Plant Growth and Bioactive Component in Turmeric (Curcuma longa L.).

PubMed

Chauhan, Ankit Kumar; Maheshwari, Dinesh Kumar; Dheeman, Shrivardhan; Bajpai, Vivek K

2017-02-01

Curcumin (diferuloyl methane) is the main bioactive component of turmeric (Curcuma longa L.) having remarkable multipotent medicinal and therapeutic applications. Two Bacilli isolated from termitarium soil and identified as Bacillus endophyticus TSH42 and Bacillus cereus TSH77 were used for bacterization of rhizome for raising C. longa ver. suguna for growth and enhancement. Both the strains showed remarkable PGP activities and also chemotactic in nature with high chemotactic index. Turmeric plants bacterized with strains B. endophyticus TSH42 and B. cereus TSH77 individually and in combination increased plant growth and turmeric production up to 18% in field trial in comparison to non-bacterized plants. High-performance liquid chromatography analysis was performed to determine the content of curcumin, which showed concentration of curcumin in un-inoculated turmeric as 3.66 g which increased by 13.6% (4.16 g) when combination of TSH42 and TSH77 was used.

Three-dimensional high-resolution diffusion tensor imaging and tractography of the developing rabbit brain.

PubMed

D'Arceuil, Helen; Liu, Christina; Levitt, Pat; Thompson, Barbara; Kosofsky, Barry; de Crespigny, Alex

2008-01-01

Diffusion tensor imaging (DTI) is sensitive to structural ordering in brain tissue particularly in the white matter tracts. Diffusion anisotropy changes with disease and also with neural development. We used high-resolution DTI of fixed rabbit brains to study developmental changes in regional diffusion anisotropy and white matter fiber tract development. Imaging was performed on a 4.7-tesla Bruker Biospec Avance scanner using custom-built solenoid coils and DTI was performed at various postnatal ages. Trace apparent diffusion coefficient, fractional diffusion anisotropy maps and fiber tracts were generated and compared across the ages. The brain was highly anisotropic at birth and white matter anisotropy increased with age. Regional DTI tractography of the internal capsule showed refinement in regional tract architecture with maturation. Interestingly, brains with congenital deficiencies of the callosal commissure showed selectively strikingly different fiber architecture compared to age-matched brains. There was also some evidence of subcortical to cortical fiber connectivity. DTI tractography of the anterior and posterior limbs of the internal capsule showed reproducibly coherent fiber tracts corresponding to known corticospinal and corticobulbar tract anatomy. There was some minor interanimal tract variability, but there was remarkable similarity between the tracts in all animals. Therefore, ex vivo DTI tractography is a potentially powerful tool for neuroscience investigations and may also reveal effects (such as fiber tract pruning during development) which may be important targets for in vivo human studies. Copyright 2007 S. Karger AG, Basel.

On the acoustics of ancient Greek and Roman theaters.

PubMed

Farnetani, Andrea; Prodi, Nicola; Pompoli, Roberto

2008-09-01

The interplay of architecture and acoustics is remarkable in ancient Greek and Roman theaters. Frequently they are nowadays lively performance spaces and the knowledge of the sound field inside them is still an issue of relevant importance. Even if the transition from Greek to Roman theaters can be described with a great architectural detail, a comprehensive and objective approach to the two types of spaces from the acoustical point of view is available at present only as a computer model study [P. Chourmouziadou and J. Kang, "Acoustic evolution of ancient Greek and Roman theaters," Appl. Acoust. 69, re (2007)]. This work addresses the same topic from the experimental point of view, and its aim is to provide a basis to the acoustical evolution from Greek to Roman theater design. First, by means of in situ and scale model measurements, the most important features of the sound field in ancient theaters are clarified and discussed. Then it has been possible to match quantitatively the role of some remarkable architectural design variables with acoustics, and it is seen how this criterion can be used effectively to define different groups of ancient theaters. Finally some more specific wave phenomena are addressed and discussed.

The enigmatic WR46: A binary or a pulsator in disguise. II. The spectroscopy

NASA Astrophysics Data System (ADS)

Veen, P. M.; van Genderen, A. M.; Crowther, P. A.; van der Hucht, K. A.

2002-04-01

We present spectroscopic monitoring of the Wolf-Rayet (WR) star WR 46 between 1989 and 1998, which has been obtained simultaneously with multicolour photometry (Veen et al. \\cite{Veen02a}, Paper I). The spectroscopic monitoring data show that the radiative fluxes of the optical emission lines (O Vi 3811/34, O Vi 5290, N V 4944, N V 4604/20, He Ii 4686, He Ii 4859, He Ii 5411, He Ii 6560) vary in concert with the photometric single-wave (sw) frequency f_sw (Paper I), and also the difference of that period between 1989 and 1991. The line-flux variability does not provide obvious support for a short second period (Paper I). The radial-velocity variations show a remarkable behaviour: usually, they display a coherent single-wave on the time scale of the double-wave period, while during some nights the radial velocity appears surprisingly to stay constant (see also Marchenko et al. \\cite{Marchenko00}). These so-called stand-stills may be related to the observed time-delay effects. A time-delay effect manifests itself in several phenomena. Firstly, the line flux shows small, but persistent, time-delays for lines originating from lower optical depths, the outer-wind lines (N V 4604/20 and He Ii). Secondly, the radial-velocity variations display much larger time-delays than the line fluxes and their behaviour appears less consistent. Assuming that the double-wave period controls the radial velocity, the stand-still is observed to start when the radial motion is in anti-phase with the presumed orbital motion. Thirdly, the outer-wind lines are observed to enter a stand-still much later than the inner-wind lines. Fourthly, the radial-velocity variations of the peaks of the emission lines precede the radial-velocity variations of the wings of those lines. In addition to line-flux- and radial-velocity variability, the He Ii 4686 emission line shows pronounced line-profile changes on a time scale of hours. Our monitoring is not sufficient to study this in detail. Furthermore, we discern a flaring behaviour, i.e., an emission bump appeared on the blue wing of two He Ii-lines (around -1700 km s-1) lasting less than 5 min. Finally, the line fluxes follow the observed brightenings, also on a time scale of years. We conclude that the short-term cyclic variability confirms the WR nature as established from the WR standard model analysis by Crowther et al. (\\cite{Crowther95}; hereafter referred to as CSH). The various time-delay effects are consistent with the formation of the spectrum in a stratified stellar wind. The outer layers trail the inner ones. The variability is inconsistent with the formation of the spectrum in a stellar disc as proposed by Niemela et al. (\\cite{Niemela95}) and Steiner & Diaz (\\cite{Steiner98}). The long-term cyclic variability of the brightness and line fluxes is related to an increase of the mass-loss-rate, and, possibly, to the period changes. The interpretation of the nature of the variability is deferred to Veen et al. (\\cite{Veen02b}, Paper III). Based on observations collected at the European Southern Observatory (ESO), La Silla, Chile.

Content Analysis of the Concept of Addiction in High School Textbooks of Iran.

PubMed

Mirzamohammadi, Mohammad Hasan; Mousavi, Sayedeh Zainab; Massah, Omid; Farhoudian, Ali

2017-01-01

This research sought to determine how well the causes of addiction, addiction harms, and prevention of addiction have been noticed in high school textbooks. We used descriptive method to select the main related components of the addiction concept and content analysis method for analyzing the content of textbooks. The study population comprised 61 secondary school curriculum textbooks and study sample consisted of 14 secondary school textbooks selected by purposeful sampling method. The tools for collecting data were "content analysis inventory" which its validity was confirmed by educational and social sciences experts and its reliability has been found to be 91%. About 67 components were prepared for content analysis and were divided to 3 categories of causes, harms, and prevention of addiction. The analysis units in this study comprised phrases, topics, examples, course topics, words, poems, images, questions, tables, and exercises. Results of the study showed that the components of the addiction concept have presented with 212 remarks in the textbooks. Also, the degree of attention given to any of the 3 main components of the addiction concept were presented as follows: causes with 52 (24.52%) remarks, harm with 89 (41.98%) remarks, and prevention with 71 (33.49%) remarks. In high school textbooks, little attention has been paid to the concept of addiction and mostly its biological dimension were addressed while social, personal, familial, and religious dimensions of addiction have been neglected.

Extent of, and variables associated with, blood pressure variability among older subjects.

PubMed

Morano, Arianna; Ravera, Agnese; Agosta, Luca; Sappa, Matteo; Falcone, Yolanda; Fonte, Gianfranco; Isaia, Gianluca; Isaia, Giovanni Carlo; Bo, Mario

2018-02-23

Blood pressure variability (BPV) may have prognostic implications for cardiovascular risk and cognitive decline; however, BPV has yet to be studied in old and very old people. Aim of the present study was to evaluate the extent of BPV and to identify variables associated with BPV among older subjects. A retrospective study of patients aged ≥ 65 years who underwent 24-h ambulatory blood pressure monitoring (ABPM) was carried out. Three different BPV indexes were calculated for systolic and diastolic blood pressure (SBP and DBP): standard deviation (SD), coefficient of variation (CV), and average real variability (ARV). Demographic variables and use of antihypertensive medications were considered. The study included 738 patients. Mean age was 74.8 ± 6.8 years. Mean SBP and DBP SD were 20.5 ± 4.4 and 14.6 ± 3.4 mmHg. Mean SBP and DBP CV were 16 ± 3 and 20 ± 5%. Mean SBP and DBP ARV were 15.7 ± 3.9 and 11.8 ± 3.6 mmHg. At multivariate analysis older age, female sex and uncontrolled mean blood pressure were associated with both systolic and diastolic BPV indexes. The use of calcium channel blockers and alpha-adrenergic antagonists was associated with lower systolic and diastolic BPV indexes, respectively. Among elderly subjects undergoing 24-h ABPM, we observed remarkably high indexes of BPV, which were associated with older age, female sex, and uncontrolled blood pressure values.

Competition and compensation

PubMed Central

Manor, Uri; Grati, M'hamed; Yengo, Christopher M.; Kachar, Bechara; Gov, Nir S.

2012-01-01

Stereocilia are actin protrusions with remarkably well-defined lengths and organization. A flurry of recent papers has reported multiple myosin motor proteins involved in regulating stereocilia structures by transporting actin-regulatory cargo to the tips of stereocilia.1-13 In our recent paper, we show that two paralogous class 3 myosins — Myo3a and Myo3b — both transport the actin-regulatory protein Espin 1 (Esp1) to stereocilia and filopodia tips in a remarkably similar, albeit non-identical fashion.1 Here we present experimental and computational data that suggests that subtle differences between these two proteins’ biophysical and biochemical properties can help us understand how these myosin species target and regulate the lengths of actin protrusions. PMID:22954581

OV Bootis: Forty Nights of World-Wide Photometry (Abstract)

NASA Astrophysics Data System (ADS)

Patterson, J.; de Miguel, E.; Barret, D.; Brincat, S.; Boardman, J., Jr.; Buczynski, D.; Campbell, T.; Cejudo, D.; Cook, L.; Cook, M. J.; Collins, D.; Cooney, W.; Dubois, F.; Dvorak, S.; Halpern, J. P.; Kroes, A. J.; Lemay, D.; Licchelli, D.; Mankel, D.; Marshall, M.; Novak, R.; Oksanen, A.; Roberts, G.; Seargeant, J.; Sears, H.; Silcox, A.; Slauson, D.; Stone, G.; Thorstensen, J. R.; Ulowetz, J.; Vanmunster, T.; Wallgren, J.; Wood, M.

2017-12-01

(Abstract only) Among the 1000 known cataclysmic variables, only one appears to belong to the "Galactic halo"-the Population II stars. We report round-the-world photometry of this star (OV Boo) during March-April 2017, when it staged its first certified dwarf-nova outburst. The star is remarkable for its short binary period (66 minutes), high proper motion, metal-poor composition, substellar secondary, sharp white-dwarf eclipses, and nonradial pulsations. Something for everybody - and it even had the good manners to erupt in northern springtime, when it transits near local midnight. Move over, SS Cyg and WZ Sge; there's a new celebrity in town!

Pineal region tumors: computed tomographic-pathologic spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Futrell, N.N.; Osborn, A.G.; Cheson. B.D.

While several computed tomographic (CT) studies of posterior third ventricular neoplasms have included descriptions of pineal tumors, few reports have concentrated on these uncommon lesions. Some authors have asserted that the CT appearance of many pineal tumors is virtually pathognomonic. A series of nine biopsy-proved pineal gland and eight other presumed tumors is presented that illustrates their remarkable heterogeneity in both histopathologic and CT appearance. These tumors included germinomas, teratocarcinomas, hamartomas, and other varieties. They had variable margination, attentuation, calcification, and suprasellar extension. Germinomas have the best response to radiation therapy. Biopsy of pineal region tumors is now feasible andmore » is recommended for treatment planning.« less

An Experimentalist's Overview of Solar Neutrinos

NASA Astrophysics Data System (ADS)

Oser, Scott M.

2012-02-01

Four decades of solar neutrino research have demonstrated that solar models do a remarkable job of predicting the neutrino fluxes from the Sun, to the extent that solar neutrinos can now serve as a calibrated neutrino source for experiments to understand neutrino oscillations and mixing. In this review article I will highlight the most significant experimental results, with emphasis on the latest model-independent measurements from the Sudbury Neutrino Observatory. The solar neutrino fluxes are seen to be generally well-determined experimentally, with no indications of time variability, while future experiments will elucidate the lower energy part of the neutrino spectrum, especially pep and CNO neutrinos.

How does informational heterogeneity affect the quality of forecasts?

NASA Astrophysics Data System (ADS)

Gualdi, S.; De Martino, A.

2010-01-01

We investigate a toy model of inductive interacting agents aiming to forecast a continuous, exogenous random variable E. Private information on E is spread heterogeneously across agents. Herding turns out to be the preferred forecasting mechanism when heterogeneity is maximal. However in such conditions aggregating information efficiently is hard even in the presence of learning, as the herding ratio rises significantly above the efficient market expectation of 1 and remarkably close to the empirically observed values. We also study how different parameters (interaction range, learning rate, cost of information and score memory) may affect this scenario and improve efficiency in the hard phase.

Patent Network Analysis and Quadratic Assignment Procedures to Identify the Convergence of Robot Technologies

PubMed Central

Lee, Woo Jin; Lee, Won Kyung

2016-01-01

Because of the remarkable developments in robotics in recent years, technological convergence has been active in this area. We focused on finding patterns of convergence within robot technology using network analysis of patents in both the USPTO and KIPO. To identify the variables that affect convergence, we used quadratic assignment procedures (QAP). From our analysis, we observed the patent network ecology related to convergence and found technologies that have great potential to converge with other robotics technologies. The results of our study are expected to contribute to setting up convergence based R&D policies for robotics, which can lead new innovation. PMID:27764196

Low resolution ultraviolet and optical spectrophotometry of symbiotic stars

NASA Technical Reports Server (NTRS)

Slovak, M. H.

1982-01-01

Low resolution International Ultraviolet Explorer spectra combined with optical spectrophotometry provide absolute flux distributions for seven symbiotic variables from 1200 to 6450 A. For five stars (EG And, BF Cyg, CI Cyg, AG Peg, and Z And) the data are representative of the quiescent/out-of-eclipse energy distributions; for CH Cyg and AX Per, the observations were obtained following their atest outburst in 1977 and 1978, respectively. The de-reddened distributions reveal a remarkable diversity of both line spectra and continua. While the optical and near infrared regions lambda = 5500 A) are well represented by single component stellar models, multicomponent flux distributions are required to reproduce the ultraviolet continua.

Lack of phonotactic preferences of female frogs and its consequences for signal evolution.

PubMed

Velásquez, Nelson A; Valdés, Jose Luis; Vásquez, Rodrigo A; Penna, Mario

2015-09-01

Sexual selection is one of the main evolutionary forces that drive signal evolution. In previous studies, we have found out that males of Pleurodema thaul, a frog with an extensive latitudinal distribution in Chile, emits advertisement calls that show remarkable variation among populations. In addition, this variation is related to intense inter-male acoustic competition (intra-sexual selection) occurring within each population. However, the extent to which female preferences contribute to the signal divergence observed is unclear. To study the responsiveness of females in each population, we stimulated females with synthetic calls designed with the acoustic structure of their own population and subsequently responsive females were subjected to a two-choice experiment, where they were stimulated with synthetic calls of their own population versus a call of a foreign population. Females do not show phonotactic preferences for calls of their own or foreign populations as measured with both linear and circular variables. The lack of phonotactic preferences suggests an absence of participation of inter-sexual selection processes in the divergence of the acoustic signals of P. thaul, highlighting the importance of intra-sexual selection for the evolution of these signals. These results concur with studies in other vertebrates emphasizing the relevance of interactions among males for the evolution of acoustic communication systems. Copyright © 2015. Published by Elsevier B.V.

Motion patterns in acupuncture needle manipulation.

PubMed

Seo, Yoonjeong; Lee, In-Seon; Jung, Won-Mo; Ryu, Ho-Sun; Lim, Jinwoong; Ryu, Yeon-Hee; Kang, Jung-Won; Chae, Younbyoung

2014-10-01

In clinical practice, acupuncture manipulation is highly individualised for each practitioner. Before we establish a standard for acupuncture manipulation, it is important to understand completely the manifestations of acupuncture manipulation in the actual clinic. To examine motion patterns during acupuncture manipulation, we generated a fitted model of practitioners' motion patterns and evaluated their consistencies in acupuncture manipulation. Using a motion sensor, we obtained real-time motion data from eight experienced practitioners while they conducted acupuncture manipulation using their own techniques. We calculated the average amplitude and duration of a sampled motion unit for each practitioner and, after normalisation, we generated a true regression curve of motion patterns for each practitioner using a generalised additive mixed modelling (GAMM). We observed significant differences in rotation amplitude and duration in motion samples among practitioners. GAMM showed marked variations in average regression curves of motion patterns among practitioners but there was strong consistency in motion parameters for individual practitioners. The fitted regression model showed that the true regression curve accounted for an average of 50.2% of variance in the motion pattern for each practitioner. Our findings suggest that there is great inter-individual variability between practitioners, but remarkable intra-individual consistency within each practitioner. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

The gender earnings gap among pharmacists.

PubMed

Carvajal, Manuel J; Armayor, Graciela M; Deziel, Lisa

2012-01-01

A gender earnings gap exists across professions. Compared with men, women earn consistently lower income levels. The determinants of wages and salaries should be explored to assess whether a gender earnings gap exists in the pharmacy profession. The objectives of this study were to (1) compare the responses of male and female pharmacists' earnings with human-capital stock, workers' preferences, and opinion variables and (2) assess whether the earnings determination models for male and female pharmacists yielded similar results in estimating the wage-and-salary gap through earnings projections, the influence of each explanatory variable, and gender differences in statistical significance. Data were collected through the use of a 37-question survey mailed to registered pharmacists in South Florida, United States. Earnings functions were formulated and tested separately for male and female pharmacists using unlogged and semilog equation forms. Number of hours worked, human-capital stock, job preferences, and opinion variables were hypothesized to explain wage-and-salary differentials. The empirical evidence led to 3 major conclusions: (1) men's and women's earnings sometimes were influenced by different stimuli, and when they responded to the same variables, the effect often was different; (2) although the influence of some explanatory variables on earnings differed in the unlogged and semilog equations, the earnings projections derived from both equation forms for male and female pharmacists were remarkably similar and yielded nearly identical male-female earnings ratios; and (3) controlling for number of hours worked, human-capital stock, job preferences, and opinion variables reduced the initial unadjusted male-female earnings ratios only slightly, which pointed toward the presence of gender bias. After controlling for human-capital stock, job-related characteristics, and opinion variables, male pharmacists continued to earn higher income levels than female pharmacists. Copyright © 2012 Elsevier Inc. All rights reserved.

Remarks on regular black holes

NASA Astrophysics Data System (ADS)

Nicolini, Piero; Smailagic, Anais; Spallucci, Euro

Recently, it has been claimed by Chinaglia and Zerbini that the curvature singularity is present even in the so-called regular black hole solutions of the Einstein equations. In this brief note, we show that this criticism is devoid of any physical content.

A remarkable oxygen-rich asymptotic giant branch variable in the Sagittarius Dwarf Irregular Galaxy

NASA Astrophysics Data System (ADS)

Whitelock, Patricia A.; Menzies, John W.; Feast, Michael W.; Marigo, Paola

2018-01-01

We report and discuss JHKS photometry for Sgr dIG, a very metal-deficient galaxy in the Local Group, obtained over 3.5 years with the Infrared Survey Facility in South Africa. Three large amplitude asymptotic giant branch variables are identified. One is an oxygen-rich star that has a pulsation period of 950 d, which was until recently undergoing hot bottom burning, with Mbol ∼ -6.7. It is surprising to find a variable of this sort in Sgr dIG, given their rarity in other dwarf irregulars. Despite its long period the star is relatively blue and is fainter, at all wavelengths shorter than 4.5 μm, than anticipated from period-luminosity relations that describe hot bottom burning stars. A comparison with models suggests it had a main-sequence mass Mi ∼ 5 M⊙ and that it is now near the end of its asymptotic giant branch evolution. The other two periodic variables are carbon stars with periods of 670 and 503 d (Mbol ∼ -5.7 and -5.3). They are very similar to other such stars found on the asymptotic giant branch of metal-deficient Local Group galaxies and a comparison with models suggests Mi ∼ 3 M⊙. We compare the number of asymptotic giant branch variables in Sgr dIG to those in NGC 6822 and IC 1613, and suggest that the differences may be due to the high specific star formation rate and low metallicity of Sgr dIG.

Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes.

PubMed

Martinelli, Simone; Krumbach, Oliver H F; Pantaleoni, Francesca; Coppola, Simona; Amin, Ehsan; Pannone, Luca; Nouri, Kazem; Farina, Luciapia; Dvorsky, Radovan; Lepri, Francesca; Buchholzer, Marcel; Konopatzki, Raphael; Walsh, Laurence; Payne, Katelyn; Pierpont, Mary Ella; Vergano, Samantha Schrier; Langley, Katherine G; Larsen, Douglas; Farwell, Kelly D; Tang, Sha; Mroske, Cameron; Gallotta, Ivan; Di Schiavi, Elia; Della Monica, Matteo; Lugli, Licia; Rossi, Cesare; Seri, Marco; Cocchi, Guido; Henderson, Lindsay; Baskin, Berivan; Alders, Mariëlle; Mendoza-Londono, Roberto; Dupuis, Lucie; Nickerson, Deborah A; Chong, Jessica X; Meeks, Naomi; Brown, Kathleen; Causey, Tahnee; Cho, Megan T; Demuth, Stephanie; Digilio, Maria Cristina; Gelb, Bruce D; Bamshad, Michael J; Zenker, Martin; Ahmadian, Mohammad Reza; Hennekam, Raoul C; Tartaglia, Marco; Mirzaa, Ghayda M

2018-01-17

Exome sequencing has markedly enhanced the discovery of genes implicated in Mendelian disorders, particularly for individuals in whom a known clinical entity could not be assigned. This has led to the recognition that phenotypic heterogeneity resulting from allelic mutations occurs more commonly than previously appreciated. Here, we report that missense variants in CDC42, a gene encoding a small GTPase functioning as an intracellular signaling node, underlie a clinically heterogeneous group of phenotypes characterized by variable growth dysregulation, facial dysmorphism, and neurodevelopmental, immunological, and hematological anomalies, including a phenotype resembling Noonan syndrome, a developmental disorder caused by dysregulated RAS signaling. In silico, in vitro, and in vivo analyses demonstrate that mutations variably perturb CDC42 function by altering the switch between the active and inactive states of the GTPase and/or affecting CDC42 interaction with effectors, and differentially disturb cellular and developmental processes. These findings reveal the remarkably variable impact that dominantly acting CDC42 mutations have on cell function and development, creating challenges in syndrome definition, and exemplify the importance of functional profiling for syndrome recognition and delineation. Copyright © 2017 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Visual Word Recognition Across the Adult Lifespan

PubMed Central

Cohen-Shikora, Emily R.; Balota, David A.

2016-01-01

The current study examines visual word recognition in a large sample (N = 148) across the adult lifespan and across a large set of stimuli (N = 1187) in three different lexical processing tasks (pronunciation, lexical decision, and animacy judgments). Although the focus of the present study is on the influence of word frequency, a diverse set of other variables are examined as the system ages and acquires more experience with language. Computational models and conceptual theories of visual word recognition and aging make differing predictions for age-related changes in the system. However, these have been difficult to assess because prior studies have produced inconsistent results, possibly due to sample differences, analytic procedures, and/or task-specific processes. The current study confronts these potential differences by using three different tasks, treating age and word variables as continuous, and exploring the influence of individual differences such as vocabulary, vision, and working memory. The primary finding is remarkable stability in the influence of a diverse set of variables on visual word recognition across the adult age spectrum. This pattern is discussed in reference to previous inconsistent findings in the literature and implications for current models of visual word recognition. PMID:27336629

Comparing multiple imputation methods for systematically missing subject-level data.

PubMed

Kline, David; Andridge, Rebecca; Kaizar, Eloise

2017-06-01

When conducting research synthesis, the collection of studies that will be combined often do not measure the same set of variables, which creates missing data. When the studies to combine are longitudinal, missing data can occur on the observation-level (time-varying) or the subject-level (non-time-varying). Traditionally, the focus of missing data methods for longitudinal data has been on missing observation-level variables. In this paper, we focus on missing subject-level variables and compare two multiple imputation approaches: a joint modeling approach and a sequential conditional modeling approach. We find the joint modeling approach to be preferable to the sequential conditional approach, except when the covariance structure of the repeated outcome for each individual has homogenous variance and exchangeable correlation. Specifically, the regression coefficient estimates from an analysis incorporating imputed values based on the sequential conditional method are attenuated and less efficient than those from the joint method. Remarkably, the estimates from the sequential conditional method are often less efficient than a complete case analysis, which, in the context of research synthesis, implies that we lose efficiency by combining studies. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Attribution analysis of runoff decline in a semiarid region of the Loess Plateau, China

NASA Astrophysics Data System (ADS)

Li, Binquan; Liang, Zhongmin; Zhang, Jianyun; Wang, Guoqing; Zhao, Weimin; Zhang, Hongyue; Wang, Jun; Hu, Yiming

2018-01-01

Climate variability and human activities are two main contributing attributions for runoff changes in the Yellow River, China. In the loess hilly-gully regions of the middle Yellow River, water shortage has been a serious problem, and this results in large-scale constructions of soil and water conservation (SWC) measures in the past decades in order to retain water for agricultural irrigation and industrial production. This disturbed the natural runoff characteristics. In this paper, we focused on a typical loess hilly-gully region (Wudinghe and Luhe River basins) and investigated the effects of SWC measures and climate variability on runoff during the period of 1961-2013, while the SWC measures were the main representative of human activities in this region. The nonparametric Mann-Kendall test was used to analyze the changes of annual precipitation, air temperature, potential evapotranspiration (PET), and runoff. The analysis revealed the decrease in precipitation, significant rise in temperature, and remarkable runoff reduction with a rate of more than 0.4 mm per year. It was found that runoff capacity in this region also decreased. Using the change point detection methods, the abrupt change point of annual runoff series was found at 1970, and thus, the study period was divided into the baseline period (1961-1970) and changed period (1971-2013). A conceptual framework based on four statistical runoff methods was used for attribution analysis of runoff decline in the Wudinghe and Luhe River basins (-37.3 and -56.4%, respectively). Results showed that runoff reduction can be explained by 85.2-90.3% (83.3-85.7%) with the SWC measures in the Wudinghe (Luhe) River basin while the remaining proportions were caused by climate variability. The findings suggested that the large-scale SWC measures demonstrated a dominant influence on runoff decline, and the change of precipitation extreme was also a promoting factor of the upward trending of SWC measures' contribution to runoff decline. This study enhances our understanding of runoff changes caused by SWC measures and climate variability in the typical semiarid region of Loess Plateau, China.

The genotypes and methylation of MAO genes as factors behind smoking behavior.

PubMed

Tiili, Emmi M; Mitiushkina, Natalia V; Sukhovskaya, Olga A; Imyanitov, Evgeny N; Hirvonen, Ari P

2017-11-01

Smoking dependence is the main cause for tobacco-related illnesses. The addiction-causing substance in tobacco, nicotine, acts through the dopamine pathway in the brain, causing several pleasurable experiences through cigarette smoking. Thus, both genetic and epigenetic factors related to dopamine metabolism may play an important role in influencing an individual's smoking behavior. We studied the 1460 C/T variation and the variable number tandem repeat polymorphism in the MAOA gene and A/G variation in intron 13 in the MAOB gene together with four DNA methylation sites in both of these genes in relation to several smoking-related phenotypes in a study population of 1230 Whites of Russian origin. The genotypes studied were found to be associated with smoking status in women; the MAOB G variant allele was more prevalent in female smokers than nonsmokers [odds ratio (OR): 2.16, 95% confidence interval (CI): 1.08-4.33], whereas a reverse relation was observed for the MAOA 1460 T-variant allele (OR: 0.44, 95% CI: 0.21-0.91) and variable number tandem repeat low-activity alleles (OR: 0.49, 95% CI: 0.24-0.98). Moreover, the mean methylation values of the CpG sites studied in the MAOA gene were related to smoking behavior in women. Similarly, several methylation patterns in the MAOB gene were associated with a smoking history, with each CpG site showing a remarkable sex dependence. Smoking behavior seems to be related to the genetic and epigenetic profile of MAO genes, with considerable individual and sex-related differences.

Global volcanic aerosol properties derived from emissions, 1990-2014, using CESM1(WACCM): VOLCANIC AEROSOLS DERIVED FROM EMISSIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mills, Michael J.; Schmidt, Anja; Easter, Richard

Accurate representation of global stratospheric aerosol properties from volcanic and non-volcanic sulfur emissions is key to understanding the cooling effects and ozone-loss enhancements of recent volcanic activity. Attribution of climate and ozone variability to volcanic activity is of particular interest in relation to the post-2000 slowing in the apparent rate of global average temperature increases, and variable recovery of the Antarctic ozone hole. We have developed a climatology of global aerosol properties from 1990 to 2014 calculated based on volcanic and non-volcanic emissions of sulfur sources. We have complied a database of volcanic SO2 emissions and plume altitudes for eruptionsmore » between 1990 and 2014, and a new prognostic capability for simulating stratospheric sulfate aerosols in version 5 of the Whole Atmosphere Community Climate Model, a component of the Community Earth System Model. Our climatology shows remarkable agreement with ground-based lidar observations of stratospheric aerosol optical depth (SAOD), and with in situ measurements of aerosol surface area density (SAD). These properties are key parameters in calculating the radiative and chemical effects of stratospheric aerosols. Our SAOD climatology represents a significant improvement over satellite-based analyses, which ignore aerosol extinction below 15 km, a region that can contain the vast majority of stratospheric aerosol extinction at mid- and high-latitudes. Our SAD climatology significantly improves on that provided for the Chemistry-Climate Model Initiative, which misses 60% of the SAD measured in situ. Our climatology of aerosol properties is publicly available on the Earth System Grid.« less

A Clue to the Extent of Convective Mixing Inside Massive Stars: The Surface Hydrogen Abundances of Luminous Blue Variables and Hydrogen-Poor Wolf-Rayet Stars

NASA Technical Reports Server (NTRS)

Stothers, Richard B.; Chin, Chao-wen

1999-01-01

Interior layers of stars that have been exposed by surface mass loss reveal aspects of their chemical and convective histories that are otherwise inaccessible to observation. It must be significant that the surface hydrogen abundances of luminous blue variables (LBVs) show a remarkable uniformity, specifically X(sub surf) = 0.3 - 0.4, while those of hydrogen-poor Wolf-Rayet (WN) stars fall, almost without exception, below these values, ranging down to X(sub surf) = 0. According to our stellar model calculations, most LBVs are post-red-supergiant objects in a late blue phase of dynamical instability, and most hydrogen-poor WN stars are their immediate descendants. If this is so, stellar models constructed with the Schwarzschild (temperature-gradient) criterion for convection account well for the observed hydrogen abundances, whereas models built with the Ledoux (density-gradient) criterion fail. At the brightest luminosities, the observed hydrogen abundances of LBVs are too large to be explained by any of our highly evolved stellar models, but these LBVs may occupy transient blue loops that exist during an earlier phase of dynamical instability when the star first becomes a yellow supergiant. Independent evidence concerning the criterion for convection, which is based mostly on traditional color distributions of less massive supergiants on the Hertzsprung-Russell diagram, tends to favor the Ledoux criterion. It is quite possible that the true criterion for convection changes over from something like the Ledoux criterion to something like the Schwarzschild criterion as the stellar mass increases.

Rapid sewage pollution assessment by means of the coverage of epilithic taxa in a coastal area in the SW Atlantic.

PubMed

Becherucci, M E; Jaubet, M L; Saracho Bottero, M A; Llanos, E N; Elías, R; Garaffo, G V

2018-07-01

The sewage pollution impact over coastal environment represents one of the main reasons explaining the deterioration of marine coastal ecosystems around the globe. This paper aims to detect promptly a putative sewage pollution impact in a Southwestern Atlantic coastal area of Argentina as well as to identify a straightforward way for monitoring, based on the relative abundance coverage of the intertidal epilithic taxa. Four sampling sites were distributed at increased distances from the sewage outfall where the cover of individual epilithic species was visually estimated. The surrounded outfall area (i.e. outfall site) resulted polluted with high percentages of organic matter in sediment and Enterococcus concentration in seawater. The structure of the community showed a remarkable difference between the polluted site (outfall site) and the unpolluted sites. The polychaete Boccardia proboscidea dominated the outfall site with variable abundances of the green algae Ulva sp. during the period of study, decreasing the diversity of the community, while the mussel Brachidontes rodriguezii and variable abundances of several algae species dominated the unpolluted sites. The monitoring of the benthic community represents an effective, non-destructive, relative inexpensive and rapid method to assess the health of the coastal environment in the study area. The large abundance of B. proboscidea along with the absence of B. rodriguezii individuals at <300m to the sewage outfall discharge allowed the success of this classical monitoring method in a temperate marine-coastal ecosystem with certain gradient of pollution. Copyright © 2018 Elsevier B.V. All rights reserved.

Irrigation as an important anthropogenic forcing on the mean and intra-seasonal variability of Indian summer monsoon

NASA Astrophysics Data System (ADS)

Agrawal, Shubhi; Chakraborty, Arindam; Karmakar, Nirupam; Moulds, Simon; Mijic, Ana; Buytaert, Wouter

2017-04-01

Decreasing trend in rainfall in the last few decades over Indo-Gangetic Plains of northern India as seen from ground-based observations, parallels stressed ground water resources, with irrigation utilising up to 90%. The decrease in mean rainfall is co-incidental with an increasing trend in irrigation. In this work, we have analysed the effect of the extensive irrigation over Gangetic Plains (GP) on monsoon climate. In the first step, the effect of irrigation on soil moisture was accessed using a high-resolution land surface model (JULES). The model was run over Gangetic basin in two scenarios: with and without irrigation. It was seen that the mean soil moisture over GP in the irrigated scenario is higher as compared to non-irrigated scenario. These soil moisture fields were then used as forcing to a state-of-the-art general circulation model with realistic land-atmosphere coupling. A decrease in June-September precipitation over GP, significant at 95% level, is noted in the model simulation with irrigation as compared to simulation without irrigation. In specific, these changes show a remarkable similarity to the long-term trend in observed rainfall spatial pattern. Moreover, weakening of the variability of intra-seasonal oscillations in the high (10-20 days) and low (30-60 days) frequency bands is noted with irrigation. Our results suggest that with shrinking ground water resources in the GP region and a decline in the summer precipitation, the water crisis could exacerbate, with irrigation contributing in a positive feedback mechanism on these tendencies.

Comparison of llama VH sequences from conventional and heavy chain antibodies.

PubMed

Vu, K B; Ghahroudi, M A; Wyns, L; Muyldermans, S

1997-01-01

Forty different PCR clones encoding a llama variable heavy chain domain were analysed. The majority of these clones are derived from heavy-chain antibody cDNA in which the entire CH1 exon is absent. It appears from the amino acid within the VHH framework 1 and 3 that all the llama clones belong to the VH III family. However, the individual llama VHH sequences differ more substantially from each other than expected for members of the same family. Several remarkable amino acid substitutions in the framework 2 hinder the proper association of the VL. However, they lay the foundation for the secretion from the endoplasmic reticulum and good solubility behaviour of llama H2 antibodies. The repertoire of the llama VHHs may be extensive due to the presence of a long CDR3-loop, often constrained by a disulfide bridge and the occurrence of H1 and H2 loop conformations not yet encountered in mice or human VHs. The variability plot of the amino acids in the VHH shows that the first hypervariable region coincides with the structural H1 loop in contrast to the situation found in mice and man where the CDR1 and H1 are slightly offset. We propose that the amino acids of the llama H1 loop participate actively in the antigen binding. All these observations are characteristic for the llama VHHs of the homodimeric heavy-chain H2 antibodies, but are not maintained in the llama clones from conventional heterotetrameric H2L2 immunoglobulins.

Conceptual design of the time-of-flight backscattering spectrometer MIRACLES, at the European Spallation Source

NASA Astrophysics Data System (ADS)

Tsapatsaris, N.; Lechner, R. E.; Markó, M.; Bordallo, H. N.

2016-08-01

In this work, we present the conceptual design of the backscattering time-of-flight spectrometer MIRACLES approved for construction at the long-pulse European Spallation Source (ESS). MIRACLES's unparalleled combination of variable resolution, high flux, extended energy, and momentum transfer (0.2-6 Å-1) ranges will open new avenues for neutron backscattering spectroscopy. Its remarkable flexibility can be attributed to 3 key elements: the long-pulse time structure and low repetition rate of the ESS neutron source, the chopper cascade that tailors the moderator pulse in the primary part of the spectrometer, and the bent Si(111) analyzer crystals arranged in a near-backscattering geometry in the secondary part of the spectrometer. Analytical calculations combined with instrument Monte-Carlo simulations show that the instrument will provide a variable elastic energy resolution, δ(ħ ω), between 2 and 32 μeV, when using a wavelength of λ ≈ 6.267 Å (Si(111)-reflection), with an energy transfer range, ħ ω, centered at the elastic line from -600 to +600 μeV. In addition, when selecting λ ≈ 2.08 Å (i.e., the Si(333)-reflection), δ(ħ ω) can be relaxed to 300 μeV and ħ ω from about 10 meV in energy gain to ca -40 meV in energy loss. Finally, the dynamic wavelength range of MIRACLES, approximately 1.8 Å, can be shifted within the interval of 2-20 Å to allow the measurement of low-energy inelastic excitations.

Conceptual design of the time-of-flight backscattering spectrometer, MIRACLES, at the European Spallation Source.

PubMed

Tsapatsaris, N; Lechner, R E; Markó, M; Bordallo, H N

2016-08-01

In this work, we present the conceptual design of the backscattering time-of-flight spectrometer MIRACLES approved for construction at the long-pulse European Spallation Source (ESS). MIRACLES's unparalleled combination of variable resolution, high flux, extended energy, and momentum transfer (0.2-6 Å(-1)) ranges will open new avenues for neutron backscattering spectroscopy. Its remarkable flexibility can be attributed to 3 key elements: the long-pulse time structure and low repetition rate of the ESS neutron source, the chopper cascade that tailors the moderator pulse in the primary part of the spectrometer, and the bent Si(111) analyzer crystals arranged in a near-backscattering geometry in the secondary part of the spectrometer. Analytical calculations combined with instrument Monte-Carlo simulations show that the instrument will provide a variable elastic energy resolution, δ(ħ ω), between 2 and 32 μeV, when using a wavelength of λ ≈ 6.267 Å (Si(111)-reflection), with an energy transfer range, ħ ω, centered at the elastic line from -600 to +600 μeV. In addition, when selecting λ ≈ 2.08 Å (i.e., the Si(333)-reflection), δ(ħ ω) can be relaxed to 300 μeV and ħ ω from about 10 meV in energy gain to ca -40 meV in energy loss. Finally, the dynamic wavelength range of MIRACLES, approximately 1.8 Å, can be shifted within the interval of 2-20 Å to allow the measurement of low-energy inelastic excitations.

Assimilation of Surface Temperature in Land Surface Models

NASA Technical Reports Server (NTRS)

Lakshmi, Venkataraman

1998-01-01

Hydrological models have been calibrated and validated using catchment streamflows. However, using a point measurement does not guarantee correct spatial distribution of model computed heat fluxes, soil moisture and surface temperatures. With the advent of satellites in the late 70s, surface temperature is being measured two to four times a day from various satellite sensors and different platforms. The purpose of this paper is to demonstrate use of satellite surface temperature in (a) validation of model computed surface temperatures and (b) assimilation of satellite surface temperatures into a hydrological model in order to improve the prediction accuracy of soil moistures and heat fluxes. The assimilation is carried out by comparing the satellite and the model produced surface temperatures and setting the "true"temperature midway between the two values. Based on this "true" surface temperature, the physical relationships of water and energy balance are used to reset the other variables. This is a case of nudging the water and energy balance variables so that they are consistent with each other and the true" surface temperature. The potential of this assimilation scheme is demonstrated in the form of various experiments that highlight the various aspects. This study is carried over the Red-Arkansas basin in the southern United States (a 5 deg X 10 deg area) over a time period of a year (August 1987 - July 1988). The land surface hydrological model is run on an hourly time step. The results show that satellite surface temperature assimilation improves the accuracy of the computed surface soil moisture remarkably.

Toronto area ozone: Long-term measurements and modeled sources of poor air quality events

NASA Astrophysics Data System (ADS)

Whaley, C. H.; Strong, K.; Jones, D. B. A.; Walker, T. W.; Jiang, Z.; Henze, D. K.; Cooke, M. A.; McLinden, C. A.; Mittermeier, R. L.; Pommier, M.; Fogal, P. F.

2015-11-01

The University of Toronto Atmospheric Observatory and Environment Canada's Centre for Atmospheric Research Experiments each has over a decade of ground-based Fourier transform infrared (FTIR) spectroscopy measurements in southern Ontario. We present the Toronto area FTIR time series from 2002 to 2013 of two tropospheric trace gases—ozone and carbon monoxide—along with surface in situ measurements taken by government monitoring programs. We interpret their variability with the GEOS-Chem chemical transport model and determine the atmospheric conditions that cause pollution events in the time series. Our analysis includes a regionally tagged O3 model of the 2004-2007 time period, which quantifies the geographical contributions to Toronto area O3. The important emission types for 15 pollution events are then determined with a high-resolution adjoint model. Toronto O3, during pollution events, is most sensitive to southern Ontario and U.S. fossil fuel NOx emissions and natural isoprene emissions. The sources of Toronto pollution events are found to be highly variable, and this is demonstrated in four case studies representing local, short-, middle-, and long-range transport scenarios. This suggests that continental-scale emission reductions could improve air quality in the Toronto region. We also find that abnormally high temperatures and high-pressure systems are common to all pollution events studied, suggesting that climate change may impact Toronto O3. Finally, we quantitatively compare the sensitivity of the surface and column measurements to anthropogenic NOx emissions and show that they are remarkably similar. This work thus demonstrates the usefulness of FTIR measurements in an urban area to assess air quality.

Rabeto plus: a valuable drug for managing functional dyspepsia.

PubMed

Ghosh, Asim; Halder, Susanta; Mandal, Sanjoy; Mandal, Arpan; Basu, Mitali; Dabholkar, Pareen

2008-11-01

The aim of the study was to evaluate and document the efficacy and tolerability of rabeto plus (FDC of rabeprazole and itopride) in management of functional dyspepsia. It was an open, prospective, non-comparative, multidose study. The patients with functional dyspepsia (NERD or non-erosive reflux disease) attending OPD of a leading, tertiary care, teaching hospital in West Bengal (BS Medical College, Bankura) were inducted in the study. A total of 46 adult patients of either sex with functional dyspepsia and a clinical diagnosis of NERD were given 1 capsule of rabeto plus before breakfast, for up to 4 weeks. Primary efficacy variables were relief from symptoms of heartburn, nausea, vomiting, waterbrash and fullness. Secondary efficacy variables were global assessment of efficacy and toleration by patients and treating physicians. The tolerability was assessed on the basis of record of spontaneously reported adverse events with their nature, intensity and outcome. Out of 55 patients enrolled in the study, 46 completed the study as planned, while 9 patients were lost to follow-up (dropped). Most patients reported near total symptom relief by the end of study. Total symptom score showed remarkable and significant improvement from baseline to end of the study. Importantly, none of the patients reported any side-effect. All participants tolerated the drug well. Moreover, response to study drug was rated as excellent or good by over 93% patients and their treating physicians. This means that 9 out 10 patients receiving rabeto plus reported desired symptom relief from dyspepsia. Thus it was concluded that rabeto plus is a valuable drug for treatment of functional dyspepsia or NERD.

Trends, interannual variability, and seasonal cycle of atmospheric methane over the western Pacific observed using voluntary observing ships

NASA Astrophysics Data System (ADS)

Terao, Y.; Kim, H.; Mukai, H.; Nojiri, Y.; Machida, T.; Tohjima, Y.; Saeki, T.; Maksyutov, S.

2012-12-01

We present an analysis of trends, interannual variability (IAV), and seasonal cycle of atmospheric methane (CH4) over the western Pacific between 55N and 35S from 1994 to 2011. Observations were made by the National Institute for Environmental Studies (NIES), Center for Global Environmental Research (CGER), using voluntary observation ships sailing between Japan and Australia/New Zealand and between Japan and North America, sampling background maritime air quasi-monthly with high resolution in latitude. We found remarkable phenomena in IAV of CH4 in the northern tropics over the western Pacific: 1) the high growth rate of 20 ppb/yr in mid-1997 ahead of the global increase in 1998, 2) the suppression of CH4 growth in 2007, 3) significantly smaller amplitude of seasonal cycle in 1999-2000 and in 2008. Results from the simulation and meteorological analysis indicated that the IAV in atmospheric circulation associated with the El Nino and La Nina significantly contributed to these events. Our observations were made at sites located relatively close to the large CH4 sources of East and Southeast Asia, which resulted in the high sensitivity of measured CH4 mixing ratios in the northern tropics to changes in atmospheric transport and emissions from East and Southeast Asia. We will show the results from inverse analysis using our ship measurements as well as other global dataset. The CH4 data set we presented here would be valuable in accurately and quantitatively estimating the global CH4 budget.

Heterogeneous phenotypes of insulin resistance and its implications for defining metabolic syndrome in Asian Indian adolescents.

PubMed

Vikram, Naval K; Misra, Anoop; Pandey, Ravindra M; Luthra, Kalpana; Wasir, Jasjeet S; Dhingra, Vibha

2006-05-01

To assess the phenotypic correlations of insulin resistance with obesity and its relationship with the metabolic syndrome in Asian Indian adolescents. We analyzed clinical, anthropometric (body mass index [BMI], waist circumference [WC]) and laboratory (fasting blood glucose [FBG], lipids and fasting serum insulin) data from 793 subjects (401 males and 392 females) aged 14-19 years randomly selected from Epidemiological Study of Adolescents and Young (ESAY) adults (n=1447). The percentile cut-offs for 14-19 years age from ESAY cohort were used for defining abnormal values of variables. We devised three sets of definitions of metabolic syndrome by including BMI and fasting insulin levels with other defining variables. Nearly 28.9% of adolescents had fasting hyperinsulinemia despite normal values of BMI, WC, FBG, lipids, and blood pressure. Remarkably, NCEP criteria with appropriate percentile cut-off points for Asian Indian adolescents identified metabolic syndrome in only six (0.8%) subjects. Inclusion of both BMI and WC in the definition resulted in increase in the prevalence of metabolic syndrome to 4.3%. With inclusion of hyperinsulinemia, the prevalence of metabolic syndrome increased to 4.2% (from 0.8%) in the modified NCEP definition, 5.2% (from 0.9%) when BMI was substituted for WC, and 10.2 (from 4.3%) when both BMI and WC were included. Our data show marked heterogeneity of phenotypes of insulin resistance and poor value of NCEP definition to identify metabolic syndrome. We propose that BMI and fasting insulin should be evaluated in candidate definitions of metabolic syndrome in Asian Indian adolescents.

The Science of Optics; The History of Art

DOE Office of Scientific and Technical Information (OSTI.GOV)

Falco, Charles

2006-06-28

Recently, renowned artist David Hockney observed that certain drawings and paintings from as early as the Renaissance seemed almost 'photographic' in detail. Following an extensive visual investigation of western art of the past 1000 years, he made the revolutionary claim that artists even of the prominence of van Eyck and Bellini must have used optical aids. However, many art historians insisted there was no supporting evidence for such a remarkable assertion. In this talk I show a wealth of optical evidence for his claim that Hockney and I subsequently discovered during an unusual, and remarkably-productive, collaboration between an artist andmore » a scientist. I also discuss the unique properties of the 'mirror lens,' and some of the implications this work has for the history of science as well as the history of art (and the modern fields of machine vision and computerized image analysis). These discoveries convincingly demonstrate optical instruments were in use - by artists, not scientists - nearly 200 years earlier than previously even thought possible, and account for the remarkable transformation in the reality of portraits that occurred early in the 15th century.« less

The Science of Optics; The History of Art

ScienceCinema

Falco, Charles

2018-05-21

Recently, renowned artist David Hockney observed that certain drawings and paintings from as early as the Renaissance seemed almost 'photographic' in detail. Following an extensive visual investigation of western art of the past 1000 years, he made the revolutionary claim that artists even of the prominence of van Eyck and Bellini must have used optical aids. However, many art historians insisted there was no supporting evidence for such a remarkable assertion. In this talk I show a wealth of optical evidence for his claim that Hockney and I subsequently discovered during an unusual, and remarkably-productive, collaboration between an artist and a scientist. I also discuss the unique properties of the 'mirror lens,' and some of the implications this work has for the history of science as well as the history of art (and the modern fields of machine vision and computerized image analysis). These discoveries convincingly demonstrate optical instruments were in use - by artists, not scientists - nearly 200 years earlier than previously even thought possible, and account for the remarkable transformation in the reality of portraits that occurred early in the 15th century.

Transparent actuators and robots based on single-layer superaligned carbon nanotube sheet and polymer composites

NASA Astrophysics Data System (ADS)

Chen, Luzhuo; Weng, Mingcen; Zhang, Wei; Zhou, Zhiwei; Zhou, Yi; Xia, Dan; Li, Jiaxin; Huang, Zhigao; Liu, Changhong; Fan, Shoushan

2016-03-01

Transparent actuators have been attracting emerging interest recently, as they demonstrate potential applications in the fields of invisible robots, tactical displays, variable-focus lenses, and flexible cellular phones. However, previous technologies did not simultaneously realize macroscopic transparent actuators with advantages of large-shape deformation, low-voltage-driven actuation and fast fabrication. Here, we develop a fast approach to fabricate a high-performance transparent actuator based on single-layer superaligned carbon nanotube sheet and polymer composites. Various advantages of single-layer nanotube sheets including high transparency, considerable conductivity, and ultra-thin dimensions together with selected polymer materials completely realize all the above required advantages. Also, this is the first time that a single-layer nanotube sheet has been used to fabricate actuators with high transparency, avoiding the structural damage to the single-layer nanotube sheet. The transparent actuator shows a transmittance of 72% at the wavelength of 550 nm and bends remarkably with a curvature of 0.41 cm-1 under a DC voltage for 5 s, demonstrating a significant advance in technological performances compared to previous conventional actuators. To illustrate their great potential usage, a transparent wiper and a humanoid robot ``hand'' were elaborately designed and fabricated, which initiate a new direction in the development of high-performance invisible robotics and other intelligent applications with transparency.Transparent actuators have been attracting emerging interest recently, as they demonstrate potential applications in the fields of invisible robots, tactical displays, variable-focus lenses, and flexible cellular phones. However, previous technologies did not simultaneously realize macroscopic transparent actuators with advantages of large-shape deformation, low-voltage-driven actuation and fast fabrication. Here, we develop a fast approach to fabricate a high-performance transparent actuator based on single-layer superaligned carbon nanotube sheet and polymer composites. Various advantages of single-layer nanotube sheets including high transparency, considerable conductivity, and ultra-thin dimensions together with selected polymer materials completely realize all the above required advantages. Also, this is the first time that a single-layer nanotube sheet has been used to fabricate actuators with high transparency, avoiding the structural damage to the single-layer nanotube sheet. The transparent actuator shows a transmittance of 72% at the wavelength of 550 nm and bends remarkably with a curvature of 0.41 cm-1 under a DC voltage for 5 s, demonstrating a significant advance in technological performances compared to previous conventional actuators. To illustrate their great potential usage, a transparent wiper and a humanoid robot ``hand'' were elaborately designed and fabricated, which initiate a new direction in the development of high-performance invisible robotics and other intelligent applications with transparency. Electronic supplementary information (ESI) available: Video records of the actuation process of the transparent wiper and the grabbing-releasing process of the transparent robot ``hand'', transmittance spectra of the PET and BOPP films, the SEM image showing the thickness of the SACNT sheet, calculation of the curvature, calculation of energy efficiency, experimental results of the control experiment, modeling of the SACNT/PET and PET/BOPP composites and experimental results of the repeatability test. See DOI: 10.1039/c5nr07237a

The Effect of Language Learning Strategies on Proficiency, Attitudes and School Achievement

PubMed Central

Habók, Anita; Magyar, Andrea

2018-01-01

This study examines language learning strategy (LLS) use in connexion with foreign language attitude, proficiency and general school achievement among lower secondary students in Years 5 and 8 (n = 868) in Hungary. An adapted version of the Strategies Inventory for Language Learning questionnaire was used for data collection. The results showed that Hungarian students mainly engage in metacognitive strategies in both years. Differences between more and less proficient language learners’ strategy use have also been found. With regard to the effect of LLS on foreign language attitude, the foreign language mark and school achievement, path analysis indicated a good fit in both years. The metacognitive, social and memory strategies primarily influenced foreign language attitudes and marks in Year 5. The metacognitive strategies had a slight impact on school achievement as well as on foreign language marks. We demonstrated the dominant effect of metacognitive strategies and the low effect of memory strategies in Year 8. In addition, metacognitive strategies also influenced foreign language marks. The effect of foreign language marks on school achievement was also remarkable. There was a strong impact on the children’s attitudes through these variables. PMID:29379461

Exact solution of a modified El Farol's bar problem: Efficiency and the role of market impact

NASA Astrophysics Data System (ADS)

Marsili, Matteo; Challet, Damien; Zecchina, Riccardo

2000-06-01

We discuss a model of heterogeneous, inductive rational agents inspired by the El Farol Bar problem and the Minority Game. As in markets, agents interact through a collective aggregate variable - which plays a role similar to price - whose value is fixed by all of them. Agents follow a simple reinforcement-learning dynamics where the reinforcement, for each of their available strategies, is related to the payoff delivered by that strategy. We derive the exact solution of the model in the “thermodynamic” limit of infinitely many agents using tools of statistical physics of disordered systems. Our results show that the impact of agents on the market price plays a key role: even though price has a weak dependence on the behavior of each individual agent, the collective behavior crucially depends on whether agents account for such dependence or not. Remarkably, if the adaptive behavior of agents accounts even “infinitesimally” for this dependence they can, in a whole range of parameters, reduce global fluctuations by a finite amount. Both global efficiency and individual utility improve with respect to a “price taker” behavior if agents account for their market impact.

Density-functional theory based on the electron distribution on the energy coordinate

NASA Astrophysics Data System (ADS)

Takahashi, Hideaki

2018-03-01

We developed an electronic density functional theory utilizing a novel electron distribution n(ɛ) as a basic variable to compute ground state energy of a system. n(ɛ) is obtained by projecting the electron density n({\\boldsymbol{r}}) defined on the space coordinate {\\boldsymbol{r}} onto the energy coordinate ɛ specified with the external potential {\\upsilon }ext}({\\boldsymbol{r}}) of interest. It was demonstrated that the Kohn-Sham equation can also be formulated with the exchange-correlation functional E xc[n(ɛ)] that employs the density n(ɛ) as an argument. It turned out an exchange functional proposed in our preliminary development suffices to describe properly the potential energies of several types of chemical bonds with comparable accuracies to the corresponding functional based on local density approximation. As a remarkable feature of the distribution n(ɛ) it inherently involves the spatially non-local information of the exchange hole at the bond dissociation limit in contrast to conventional approximate functionals. By taking advantage of this property we also developed a prototype of the static correlation functional E sc including no empirical parameters, which showed marked improvements in describing the dissociations of covalent bonds in {{{H}}}2,{{{C}}}2{{{H}}}4 and {CH}}4 molecules.

Plasticity Regulators Modulate Specific Root Traits in Discrete Nitrogen Environments

PubMed Central

Gifford, Miriam L.; Banta, Joshua A.; Katari, Manpreet S.; Hulsmans, Jo; Chen, Lisa; Ristova, Daniela; Tranchina, Daniel; Purugganan, Michael D.; Coruzzi, Gloria M.; Birnbaum, Kenneth D.

2013-01-01

Plant development is remarkably plastic but how precisely can the plant customize its form to specific environments? When the plant adjusts its development to different environments, related traits can change in a coordinated fashion, such that two traits co-vary across many genotypes. Alternatively, traits can vary independently, such that a change in one trait has little predictive value for the change in a second trait. To characterize such “tunability” in developmental plasticity, we carried out a detailed phenotypic characterization of complex root traits among 96 accessions of the model Arabidopsis thaliana in two nitrogen environments. The results revealed a surprising level of independence in the control of traits to environment – a highly tunable form of plasticity. We mapped genetic architecture of plasticity using genome-wide association studies and further used gene expression analysis to narrow down gene candidates in mapped regions. Mutants in genes implicated by association and expression analysis showed precise defects in the predicted traits in the predicted environment, corroborating the independent control of plasticity traits. The overall results suggest that there is a pool of genetic variability in plants that controls traits in specific environments, with opportunity to tune crop plants to a given environment. PMID:24039603

Carbon material@Chitosan composite as catalyst on the synthesis of FAME from used-cooking oil with electrocatalytic process

NASA Astrophysics Data System (ADS)

Syah Putra, Rudy; Antono, Yudi; Pratama, Kharis

2017-07-01

The conversion of fatty acid methyl ester (FAME) from soybean oil with a carbon@chitosan composite as alkaline catalyst using electrolysis process had been investigated. The carbon was added onto chitosan through sol-gel method. Carbon material@chitosan, featured with high electrical conductivity and large surface area and Scanning electron microscopy equipped with an energy dispersive spectroscope (EDS) detector was performed to characterize the microstructures as-prepared alcolgels composite. The evaluation of the synthesis process was followed by GC-MS, determining the fatty acid methyl ester (FAME) ratio at different operation variables (e.g oil:MeOH molar ratio at 1:6, THF:MeOH ratio at 1:1 v/v, 10 V and 60 mins). The results showed that the incorporation of carbon resulted in an observable change in the porous structure and an obvious increase in the conductivity strength. When compared with graphite@chitosan composite as catalyst, the carbon@chitosan composite exhibits remarkably FAME yields of 100% in 20 wt.% catalyst loading. The application of those processes was also evaluated when using used-cooking oil as a feedstock of biodiesel production.

Corruption and use of antibiotics in regions of Europe.

PubMed

Rönnerstrand, Björn; Lapuente, Victor

2017-03-01

The aim of this article is to investigate the association between corruption and antibiotic use at sub-national level. We explore the correlation between, on the one hand, two measures of corruption (prevalence of corruption in the health sector and prevalence of bribes in the society) at regional level from the European Quality of Government Index; and, on the other, the consumption of antibiotics in those European regions from a 2009 Special Euro Barometer. In a multivariate regression model, we control for potential confounders: purchasing power of standardized regional gross domestic product, inhabitants per medical doctor and age-standardized all-cause mortality rates. We find that there is a strong positive association between both measures of corruption (i.e. in the health sector, and in the society at large) and antibiotics use; and that this association is robust to the introduction of the control variables. These results support previous findings in the literature linking corruption to higher antibiotic use at cross-national level. We show that corruption does seem to account for some of the remarkable between-region variation in antibiotic consumption in Europe. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions

PubMed Central

Kasischke, Karl A; Lambert, Elton M; Panepento, Ben; Sun, Anita; Gelbard, Harris A; Burgess, Robert W; Foster, Thomas H; Nedergaard, Maiken

2011-01-01

Oxygen transport imposes a possible constraint on the brain's ability to sustain variable metabolic demands, but oxygen diffusion in the cerebral cortex has not yet been observed directly. We show that concurrent two-photon fluorescence imaging of endogenous nicotinamide adenine dinucleotide (NADH) and the cortical microcirculation exposes well-defined boundaries of tissue oxygen diffusion in the mouse cortex. The NADH fluorescence increases rapidly over a narrow, very low pO2 range with a p50 of 3.4±0.6 mm Hg, thereby establishing a nearly binary reporter of significant, metabolically limiting hypoxia. The transient cortical tissue boundaries of NADH fluorescence exhibit remarkably delineated geometrical patterns, which define the limits of tissue oxygen diffusion from the cortical microcirculation and bear a striking resemblance to the ideal Krogh tissue cylinder. The visualization of microvessels and their regional contribution to oxygen delivery establishes penetrating arterioles as major oxygen sources in addition to the capillary network and confirms the existence of cortical oxygen fields with steep microregional oxygen gradients. Thus, two-photon NADH imaging can be applied to expose vascular supply regions and to localize functionally relevant microregional cortical hypoxia with micrometer spatial resolution. PMID:20859293

Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions.

PubMed

Kasischke, Karl A; Lambert, Elton M; Panepento, Ben; Sun, Anita; Gelbard, Harris A; Burgess, Robert W; Foster, Thomas H; Nedergaard, Maiken

2011-01-01

Oxygen transport imposes a possible constraint on the brain's ability to sustain variable metabolic demands, but oxygen diffusion in the cerebral cortex has not yet been observed directly. We show that concurrent two-photon fluorescence imaging of endogenous nicotinamide adenine dinucleotide (NADH) and the cortical microcirculation exposes well-defined boundaries of tissue oxygen diffusion in the mouse cortex. The NADH fluorescence increases rapidly over a narrow, very low pO(2) range with a p(50) of 3.4 ± 0.6 mm Hg, thereby establishing a nearly binary reporter of significant, metabolically limiting hypoxia. The transient cortical tissue boundaries of NADH fluorescence exhibit remarkably delineated geometrical patterns, which define the limits of tissue oxygen diffusion from the cortical microcirculation and bear a striking resemblance to the ideal Krogh tissue cylinder. The visualization of microvessels and their regional contribution to oxygen delivery establishes penetrating arterioles as major oxygen sources in addition to the capillary network and confirms the existence of cortical oxygen fields with steep microregional oxygen gradients. Thus, two-photon NADH imaging can be applied to expose vascular supply regions and to localize functionally relevant microregional cortical hypoxia with micrometer spatial resolution.

MELAS syndrome and cardiomyopathy: linking mitochondrial function to heart failure pathogenesis.

PubMed

Hsu, Ying-Han R; Yogasundaram, Haran; Parajuli, Nirmal; Valtuille, Lucas; Sergi, Consolato; Oudit, Gavin Y

2016-01-01

Heart failure remains an important clinical burden, and mitochondrial dysfunction plays a key role in its pathogenesis. The heart has a high metabolic demand, and mitochondrial function is a key determinant of myocardial performance. In mitochondrial disorders, hypertrophic remodeling is the early pattern of cardiomyopathy with progression to dilated cardiomyopathy, conduction defects and ventricular pre-excitation occurring in a significant proportion of patients. Cardiac dysfunction occurs in approximately a third of patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, a stereotypical example of a mitochondrial disorder leading to a cardiomyopathy. We performed unique comparative ultrastructural and gene expression in a MELAS heart compared with non-failing controls. Our results showed a remarkable increase in mitochondrial inclusions and increased abnormal mitochondria in MELAS cardiomyopathy coupled with variable sarcomere thickening, heterogeneous distribution of affected cardiomyocytes and a greater elevation in the expression of disease markers. Investigation and management of patients with mitochondrial cardiomyopathy should follow the well-described contemporary heart failure clinical practice guidelines and include an important role of medical and device therapies. Directed metabolic therapy is lacking, but current research strategies are dedicated toward improving mitochondrial function in patients with mitochondrial disorders.

Equilibrium and nonequilibrium properties of Boolean decision problems on scale-free graphs with competing interactions with external biases

NASA Astrophysics Data System (ADS)

Zhu, Zheng; Andresen, Juan Carlos; Janzen, Katharina; Katzgraber, Helmut G.

2013-03-01

We study the equilibrium and nonequilibrium properties of Boolean decision problems with competing interactions on scale-free graphs in a magnetic field. Previous studies at zero field have shown a remarkable equilibrium stability of Boolean variables (Ising spins) with competing interactions (spin glasses) on scale-free networks. When the exponent that describes the power-law decay of the connectivity of the network is strictly larger than 3, the system undergoes a spin-glass transition. However, when the exponent is equal to or less than 3, the glass phase is stable for all temperatures. First we perform finite-temperature Monte Carlo simulations in a field to test the robustness of the spin-glass phase and show, in agreement with analytical calculations, that the system exhibits a de Almeida-Thouless line. Furthermore, we study avalanches in the system at zero temperature to see if the system displays self-organized criticality. This would suggest that damage (avalanches) can spread across the whole system with nonzero probability, i.e., that Boolean decision problems on scale-free networks with competing interactions are fragile when not in thermal equilibrium.

Functional relevance of interindividual differences in temporal lobe callosal pathways: a DTI tractography study.

PubMed

Westerhausen, René; Grüner, Renate; Specht, Karsten; Hugdahl, Kenneth

2009-06-01

The midsagittal corpus callosum is topographically organized, that is, with regard to their cortical origin several subtracts can be distinguished within the corpus callosum that belong to specific functional brain networks. Recent diffusion tensor tractography studies have also revealed remarkable interindividual differences in the size and exact localization of these tracts. To examine the functional relevance of interindividual variability in callosal tracts, 17 right-handed male participants underwent structural and diffusion tensor magnetic resonance imaging. Probabilistic tractography was carried out to identify the callosal subregions that interconnect left and right temporal lobe auditory processing areas, and the midsagittal size of this tract was seen as indicator of the (anatomical) strength of this connection. Auditory information transfer was assessed applying an auditory speech perception task with dichotic presentations of consonant-vowel syllables (e.g., /ba-ga/). The frequency of correct left ear reports in this task served as a functional measure of interhemispheric transfer. Statistical analysis showed that a stronger anatomical connection between the superior temporal lobe areas supports a better information transfer. This specific structure-function association in the auditory modality supports the general notion that interindividual differences in callosal topography possess functional relevance.

Delivery of GM-CSF to Protect against Influenza Pneumonia

PubMed Central

Subramaniam, Renuka; Hillberry, Zachary; Chen, Han; Feng, Yan; Fletcher, Kalyn; Neuenschwander, Pierre; Shams, Homayoun

2015-01-01

Background Since adaptive immunity is thought to be central to immunity against influenza A virus (IAV) pneumonias, preventive strategies have focused primarily on vaccines. However, vaccine efficacy has been variable, in part because of antigenic shift and drift in circulating influenza viruses. Recent studies have highlighted the importance of innate immunity in protecting against influenza. Methods Granulocyte-macrophage colony stimulating factor (GM-CSF) contributes to maturation of mononuclear phagocytes, enhancing their capacity for phagocytosis and cytokine production. Results Overexpression of granulocyte macrophage-colony stimulating factor (GM-CSF) in the lung of transgenic mice provides remarkable protection against IAV, which depends on alveolar macrophages (AM). In this study, we report that pulmonary delivery of GM-CSF to wild type young and aged mice abrogated mortality from IAV. Conclusion We also demonstrate that protection is species specific and human GM-CSF do not protect the mice nor stimulates mouse immunity. We also show that IAV-induced lung injury is the culprit for side-effects of GM-CSF in treating mice after IAV infection, and introduce a novel strategy to deliver the GM-CSF to and retain it in the alveolar space even after IAV infection. PMID:25923215

Cubic liquid crystalline nanoparticles: optimization and evaluation for ocular delivery of tropicamide.

PubMed

Verma, Purnima; Ahuja, Munish

2016-10-01

The purpose of this study was to investigate the potential of cubic liquid crystalline nanoparticles for ocular delivery of tropicamide. Ultrasound-assisted fragmentation of cubic liquid crystalline bulk phases resulted in cubic liquid crystalline nanoparticles employing Pluronic F127 as dispersant. The effects of process variables such as sonication time, sonication amplitude, sonication depth, and pre-mixing time on particle size and polydispersity index was investigated using central composite design. The morphology of tropicamide-loaded nanoparticles was found to be nearly cubical in shape by transmission electron microscopy observation. Further, small angle X-ray scattering experiment confirmed the presence of D and P phase cubic structures in coexistence. The optimized tropicamide-loaded cubic nanoparticles showed in vitro corneal permeation of tropicamide across isolated porcine cornea comparable to its commercial preparation, Tropicacyl®. Ocular tolerance was evaluated by Hen's egg-chorioallantoic membrane test and histological studies. The results of in vivo mydriatic response study demonstrated a remarkably higher area under mydriatic response curve (AUC 0→1440 min ) values of cubic nanoparticles over Tropicacyl® indicating better therapeutic value of cubic nanoparticles. Furthermore, tropicamide-loaded cubic nanoparticles exhibited prolonged mydriatic effect on rabbits as compared to commercial conventional aqueous ophthalmic solution.

Measurements of atmospheric mercury with high time resolution: recent applications in environmental research and monitoring.

PubMed

Ebinghaus, R; Kock, H H; Schmolke, S R

2001-11-01

In the past five years automated high time-resolution measurements of mercury species in ambient air have promoted remarkable progress in the understanding of the spatial distribution, short-term variability, and fate of this priority pollutant in the lower troposphere. Examples show the wide range of possible applications of these techniques in environmental research and monitoring. Presented applications of measurement methods for total gaseous mercury (TGM) include long-term monitoring of atmospheric mercury at a coastal station, simultaneous measurements during a south-to-north transect measurement campaign covering a distance of approximately 800 km, the operation on board of a research aircraft, and the quantification of mercury emissions from naturally enriched surface soils. First results obtained with a new method for the determination of reactive gaseous mercury (RGM) are presented. Typical background concentrations of TGM are between 1.5 and 2 ng m(-3) in the lower troposphere. Concentrations of RGM have been determined at a rural site in Germany between 2 and 35 pg m(-3). Flux measurements over naturally enriched surface soils in the Western U.S.A. have revealed emission fluxes of up to 200 ng Hg m(-1) h(-1) under dry conditions.

Effects of Increasing Doses of UV-B on Main Phenolic Acids Content, Antioxidant Activity and Estimated Biomass in Lavandin (Lavandula x intermedia).

PubMed

Usano-Alemany, Jaime; Panjai, Lachinee

2015-07-01

Lavandin is a well-known aromatic plant cultivated mainly for its valuable essential oil. Nonetheless, little attention has been paid so far to the quantification of other natural products such as polyphenols. Accordingly, we examined the effect of increasing doses of UV-B radiation on the main phenolic content, antioxidant activity and estimated biomass of one year old lavandin pots compared with pots grown outdoors. Significantly higher total phenolic content and concentration of main polyphenols have been found in outdoor plants. Rosmarinic acid has been described as the major phenolic compound in methanolic extracts (max. 25.9 ± 9.7 mg/g(-1) DW). Furthermore, we found that increasing doses of UV-B promote the plant growth of this species as well as the accumulation of phenolic compounds although with less antioxidant capacity in scavenging DPPH radicals. On the other hand, our results showed a remarkable variability among individual plants regarding the content of major phenolic acids. The application of UV-B doses during plant growth could be a method to promote biomass in this species along with the promotion of higher content of valuable secondary metabolites.

Is healthcare a 'Necessity' or 'Luxury'? an empirical evidence from public and private sector analyses of South-East Asian countries?

PubMed

Khan, Jahangir Am; Mahumud, Rashidul Alam

2015-01-01

South-East Asian Regional (SEAR) countries range from low- to middle-income countries and have considerable differences in mix of public and private sector expenditure on health. This study intends to estimate the income-elasticities of healthcare expenditure in public and private sectors separately for investigating whether healthcare is a 'necessity' or 'luxury' for citizens of these countries. Panel data from 9 SEAR countries over 16 years (1995-2010) were employed. Fixed- and random-effect models were fitted to estimate income-elasticity of public, private and total healthcare expenditure. Results showed that one percent point increase in GDP per capita increased private expenditure on healthcare by 1.128%, while public expenditure increased by only 0.412%. Inclusion of three-year lagged variables of GDP per capita in the models did not have remarkable influence on the findings. The citizens of SEAR countries consider healthcare as a necessity while provided through public sector and a luxury when delivered by private sector. By increasing the public provisions of healthcare, more redistribution of healthcare resources can be ensured, which can accelerate the journey of SEAR countries towards universal health coverage.

The relationship of neurogenesis and growth of brain regions to song learning

PubMed Central

Kirn, John R.

2009-01-01

Song learning, maintenance and production require coordinated activity across multiple auditory, sensory-motor, and neuromuscular structures. Telencephalic components of the sensory-motor circuitry are unique to avian species that engage in song learning. The song system shows protracted development that begins prior to hatching but continues well into adulthood. The staggered developmental timetable for construction of the song system provides clues of subsystems involved in specific stages of song learning and maintenance. Progressive events, including neurogenesis and song system growth, as well as regressive events such as apoptosis and synapse elimination, occur during periods of song learning and the transitions between stereotyped and variable song during both development and adulthood. There is clear evidence that gonadal steroids influence the development of song attributes and shape the underlying neural circuitry. Some aspects of song system development are influenced by sensory, motor and social experience, while other aspects of neural development appear to be experience-independent. Although there are species differences in the extent to which song learning continues into adulthood, growing evidence suggests that despite differences in learning trajectories, adult refinement of song motor control and song maintenance can require remarkable behavioral and neural flexibility reminiscent of sensory-motor learning. PMID:19853905

Optical transitions in GaNAs quantum wells with variable nitrogen content embedded in AlGaAs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elborg, M., E-mail: ELBORG.Martin@nims.go.jp; Noda, T.; Mano, T.

2016-06-15

We investigate the optical transitions of GaN{sub x}As{sub 1−x} quantum wells (QWs) embedded in wider band gap AlGaAs. A combination of absorption and emission spectroscopic techniques is employed to systematically investigate the properties of GaNAs QWs with N concentrations ranging from 0 – 3%. From measurement of the photocurrent spectra, we find that besides QW ground state and first excited transition, distinct increases in photocurrent generation are observed. Their origin can be explained by N-induced modifications in the density of states at higher energies above the QW ground state. Photoluminescence experiments reveal that peak position dependence with temperature changes withmore » N concentration. The characteristic S-shaped dependence for low N concentrations of 0.5% changes with increasing N concentration where the low temperature red-shift of the S-shape gradually disappears. This change indicates a gradual transition from impurity picture, where localized N induced energy states are present, to alloying picture, where an impurity-band is formed. In the highest-N sample, photoluminescence emission shows remarkable temperature stability. This phenomenon is explained by the interplay of N-induced energy states and QW confined states.« less

Hypothalamic-pituitary-adrenal axis reactivity to psychological stress and memory in middle-aged women: high responders exhibit enhanced declarative memory performance.

PubMed

Domes, G; Heinrichs, M; Reichwald, U; Hautzinger, M

2002-10-01

According to recent studies, elevated cortisol levels are associated with impaired declarative memory performance. This specific effect of cortisol has been shown in several studies using pharmacological doses of cortisol. The present study was designed to determine the effects of endogenously stimulated cortisol secretion on memory performance in healthy middle-aged women. For psychological stress challenging, we employed the Trier Social Stress Test (TSST). Subjects were assigned to either the TSST or a non-stressful control condition. Declarative and non-declarative memory performance was measured by a combined priming-free-recall-task. No significant group differences were found for memory performance. Post hoc analyses of variance indicated that regardless of experimental condition the subjects with remarkably high cortisol increase in response to the experimental procedure (high responders) showed increased memory performance in the declarative task compared to subjects with low cortisol response (low responders). The results suggest that stress-induced cortisol failed to impair memory performance. The results are discussed with respect to gender-specific effects and modulatory effects of the sympathetic nervous system and psychological variables. Copyright 2002 Elsevier Science Ltd.

Dynamic and thermodynamic impacts of the winter Arctic Oscillation on summer sea ice extent.

NASA Astrophysics Data System (ADS)

Park, H. S.; Stewart, A.

2017-12-01

Arctic summer sea ice extent exhibits substantial interannual variability, as is highlighted by the remarkable recovery in sea ice extent in 2013 following the record minimum in the summer of 2012. Here, we explore the mechanism via which Arctic Oscillation (AO)-induced ice thickness changes impact summer sea ice, using observations and reanalysis data. A positive AO weakens the basin-scale anticyclonic sea ice drift and decreases the winter ice thickness by 15cm and 10cm in the Eurasian and the Pacific sectors of the Arctic respectively. Three reanalysis datasets show that the (upward) surface heat fluxes are reduced over wide areas of the Arctic, suppressing the ice growth during the positive AO winters. The winter dynamic and thermodynamic thinning preconditions the ice for enhanced radiative forcing via the ice-albedo feedback in late spring-summer, leading to an additional 8-10 cm of thinning over the Pacific sector of the Arctic. Because of these winter AO-induced dynamic and thermodynamics effects, the winter AO explains about 22% (r = -0.48) of the interannual variance of September sea ice extent from year 1980 to 2015.

Dorzolamide Loaded Niosomal Vesicles: Comparison of Passive and Remote Loading Methods.

PubMed

Hashemi Dehaghi, Mohadeseh; Haeri, Azadeh; Keshvari, Hamid; Abbasian, Zahra; Dadashzadeh, Simin

2017-01-01

Glaucoma is a common progressive eye disorder and the treatment strategies will benefit from nanoparticulate delivery systems with high drug loading and sustained delivery of intraocular pressure lowering agents. Niosomes have been reported as a novel approach to improve drug low corneal penetration and bioavailability characteristics. Along with this, poor entrapment efficiency of hydrophilic drug in niosomal formulation remains as a major formulation challenge. Taking this perspective into consideration, dorzolamide niosomes were prepared employing two different loading methodologies (passive and remote loading methods) and the effects of various formulation variables (lipid to drug ratio, cholesterol percentage, drug concentration, freeze/thaw cycles, TPGS content, and external and internal buffer molarity and pH) on encapsulation efficiency were assessed. Encapsulation of dorzolamide within niosomes increased remarkably by the incorporation of higher cholesterol percentage as well as increasing the total lipid concentration. Remote loading method showed higher efficacy for drug entrapment compared to passive loading technique. Incorporation of TPGS in bilayer led to decrease in EE; however, retarded drug release rate. Scanning electron microscopy (SEM) studies confirmed homogeneous particle distribution, and spherical shape with smooth surface. In conclusion, the highest encapsulation can be obtained using phosphate gradient method and 50% cholesterol in Span 60 niosomal formulation.

Active Inference and Learning in the Cerebellum.

PubMed

Friston, Karl; Herreros, Ivan

2016-09-01

This letter offers a computational account of Pavlovian conditioning in the cerebellum based on active inference and predictive coding. Using eyeblink conditioning as a canonical paradigm, we formulate a minimal generative model that can account for spontaneous blinking, startle responses, and (delay or trace) conditioning. We then establish the face validity of the model using simulated responses to unconditioned and conditioned stimuli to reproduce the sorts of behavior that are observed empirically. The scheme's anatomical validity is then addressed by associating variables in the predictive coding scheme with nuclei and neuronal populations to match the (extrinsic and intrinsic) connectivity of the cerebellar (eyeblink conditioning) system. Finally, we try to establish predictive validity by reproducing selective failures of delay conditioning, trace conditioning, and extinction using (simulated and reversible) focal lesions. Although rather metaphorical, the ensuing scheme can account for a remarkable range of anatomical and neurophysiological aspects of cerebellar circuitry-and the specificity of lesion-deficit mappings that have been established experimentally. From a computational perspective, this work shows how conditioning or learning can be formulated in terms of minimizing variational free energy (or maximizing Bayesian model evidence) using exactly the same principles that underlie predictive coding in perception.

Transient Impact of Rituximab in H1N1 Vaccination-associated Narcolepsy With Severe Psychiatric Symptoms.

PubMed

Sarkanen, Tomi; Alén, Reija; Partinen, Markku

2016-09-01

Narcolepsy type 1 is an organic sleep disorder caused by the destruction of hypocretin producing neurons in hypothalamus. In addition to daytime sleepiness, the spectrum and severity of symptoms are very variable. Psychiatric comorbidity and phenomena resembling psychotic symptoms are also common. Current treatment options for narcolepsy are symptomatic but there are few case reports of positive effect of immunotherapy. We report a very severely affected young boy treated with rituximab (RXB). A 12-year-old boy developed narcolepsy after Pandemrix H1N1 vaccination in 2010. He started to express severe psychiatric symptoms shortly after the onset. Cataplexy and sleepiness were devastatingly disabling. Conventional treatments did not have any effect on symptoms so we decided to try RXB, chimeric human monoclonal antibody against CD20 expressed in B lymphocytes. After the first treatment his condition ameliorated dramatically. Unfortunately, the effect lasted only for 2 months. Following attempts did not show any effect. Effect of RXB on narcolepsy has not been reported before. Remarkable but short-lasting effect of RXB in narcolepsy is intriguing as it could imply that there is still ongoing B cell-mediated autoimmune response possible contributing to symptoms in narcolepsy.

Multi-Proxy Evidence for Decoupled Monsoon Intensity and Southeast Asian Precipitation on Orbital and Millennial Timescales

NASA Astrophysics Data System (ADS)

Johnson, K. R.; Griffiths, M. L.; Borsato, A.; Frisia, S.; Bhattacharya, T.; Tierney, J. E.; LeGrande, A. N.; Henderson, G. M.

2017-12-01

Despite significant advances in our understanding of Asian monsoon variability on orbital to millennial timescales, we still know very little about the range and mechanisms of variability in the Southeast Asian monsoon region. To address this need, we have developed a decadally-resolved and replicated speleothem δ18O and δ13C record from Tham Doun Mai Cave in Northern Laos. The record spans the period from 37.7 kyr BP to the present and the age model is constrained by 35 U-Th dates. The orbital and millennial scale δ18O variability is remarkably similar to other Asian speleothem records, with the lowest values observed during the early Holocene summer insolation maxima and clear δ18O increases observed during Heinrich Stadials (HS) 1-3, the Younger Dryas, and the 8.2 kyr event. The strong similarity with Chinese speleothem δ18O records suggests that variations in upstream rainout over the Indian Ocean, Bay of Bengal, and Indian Monsoon region are the dominant control on orbital and millennial scale precipitation δ18O variability across Southeast and East Asia. In contrast to δ18O, TM speleothem δ13C is reflective of local hydroclimate. The δ13C record shows large positive excursions during HS 1-3, suggesting dry conditions during these events. Positive δ13C values during the early Holocene indicate dry conditions in SE Asia were synchronous with increased upstream rainout. This interpretation is further supported by crystal fabric and greyscale analyses, which reflect internal porosity changes likely related to infiltration variability. Compact columnar, translucent calcite is associated with decreased infiltration, and typifies HS events and the early Holocene. The positive δ13C excursions during these periods may then be enhanced by the prolonged degassing associated with slower drip rates. Time-slice simulations conducted with the isotope-enabled GISS Model E further support a dry early Holocene in this region. Model analyses suggest dry conditions in SE Asia during insolation maxima may arise from decreased low-level moisture convergence over the Indo-China Peninsula as precipitation over India and East Asia increases, effectively drawing away moisture from our study site. Nevertheless, the impacts of upstream rainout lead to regionally coherent δ18O decreases across the broad Asian monsoon region.

Highly efficient conductivity modulation of cinnamate-based light-responsive ionic liquids in aqueous solutions.

PubMed

Yang, Jie; Wang, Huiyong; Wang, Jianji; Zhang, Yue; Guo, Zhongjia

2014-12-11

A new class of cinnamate-based light-responsive ionic liquids was synthesized and characterized, and these ionic liquids with longer alkyl chains showed a remarkable increase in ionic conductivity under UV light irradiation in aqueous solutions.

Personality and Treatment Effectiveness in Anorexia Nervosa.

ERIC Educational Resources Information Center

Skoog, Dagna K.; And Others

1984-01-01

Compared pre- and posttreatment Minnesota Multiphasic Personality Inventory profiles of female inpatients (N=12) with anorexia nervosa. Results showed change after treatment, and found that pretreatment profiles obtained at a different hospital were remarkably similar, which suggests a common constellation of personality characteristics in…

Characterization of Aral Sea Particulate Matter in Kyrgyzstan

EPA Science Inventory

1. Elemental analyses of resuspendable soils from the Aral Sea region and Kyrgyz soils show that the composition of the soils are remarkably uniform thereby supporting chemical source apportionment models that treat this region as a homogeneous source with respect to elemental co...

Ultrasensitive detection of nucleic acids by template enhanced hybridization followed by rolling circle amplification and catalytic hairpin assembly.

PubMed

Song, Weiling; Zhang, Qiao; Sun, Wenbo

2015-02-11

An ultrasensitive protocol for fluorescent detection of DNA is designed by combining the template enhanced hybridization process (TEHP) with Rolling Circle Amplification (RCA) and Catalytic Hairpin Assembly (CHA), showing a remarkable amplification efficiency.

[Dust storms trend in the Capital Circle of China over the past 50 years and its correlation with temperature, precipitation and wind].

PubMed

Chen, Yu-fu; Tang, Hai-ping

2005-01-01

The trends of number of dust storm days of the selected 11 meteorological stations from their established year to 2000 as well as their correlations with temperature, precipitation and wind are revealed. The number of dust storm days of the Capital Circle of China is distinctly variable in space and time. The numbers of dust storm days of the western area are far more than those of the eastern area. The interannual variability of number of dust storm days is remarkable. The number of dust storm days of the following 7 stations, Erlianhaote, Abaga, Xilinhaote, Fengning, Zhangjiakou, Huailai and Beijing, declined along the past decades, but those of the other four stations had no significant upward or downward trends. There is a marked seasonality of the number of dust storm days, and the maximum was in April. The correlation between number of dust storm days and number of days of mean wind velocity > 5 m/s, which is critical wind velocity to entrain sand into the air, was strongest among the three climatic factor. There were significant positive correlations between the number of dust storm days and number of days of mean wind velocity > 5 m/s in 6 stations. The second strongest climatic factor correlated with the number of dust storm days is temperature. There are significant negative correlations between the number of dust storm days and mean annual temperature, mean winter temperature, mean spring temperature in 3 or 4 stations. The correlation between the number of dust storm days and precipitation is weakest. Only one station, Zhurihe, showes significant negative correlation between the number of dust storm days and spring rainfall. There are 4 stations whose number of dust storm days don't significantly correlate with the climate. In the end, the spatial-temporal variability of dust storms and its relation with climate in the Capital Circle of China were discussed thoroughly.

Evolution of African swine fever virus genes related to evasion of host immune response.

PubMed

Frączyk, Magdalena; Woźniakowski, Grzegorz; Kowalczyk, Andrzej; Bocian, Łukasz; Kozak, Edyta; Niemczuk, Krzysztof; Pejsak, Zygmunt

2016-09-25

African swine fever (ASF) is a notifiable and one of the most complex and devastating infectious disease of pigs, wild boars and other representatives of Suidae family. African swine fever virus (ASFV) developed various molecular mechanisms to evade host immune response including alteration of interferon production by multigene family protein (MGF505-2R), inhibition of NF-κB and nuclear activating factor in T-cells by the A238L protein, or modulation of host defense by CD2v lectin-like protein encoded by EP402R and EP153R genes. The current situation concerning ASF in Poland seems to be stable in comparison to other eastern European countries but up-to-date in total 106 ASF cases in wild boar and 5 outbreaks in pigs were identified. The presented study aimed to reveal and summarize the genetic variability of genes related to inhibition or modulation of infected host response among 67 field ASF isolates collected from wild boar and pigs. The nucleotide sequences derived from the analysed A238L and EP153R regions showed 100% identity. However, minor but remarkable genetic diversity was found within EP402R and MGF505-2R genes suggesting slow molecular evolution of circulating ASFV isolates and the important role of this gene in modulation of interferon I production and hemadsorption phenomenon. The obtained nucleotide sequences of Polish ASFV isolates were closely related to Georgia 2007/1 and Odintsovo 02/14 isolates suggesting their common Caucasian origin. In the case of EP402R and partially in MGF505-2R gene the identified genetic variability was related to spatio-temporal occurrence of particular cases and outbreaks what may facilitate evolution tracing of ASFV isolates. This is the first report indicating identification of genetic variability within the genes related to evasion of host immune system which may be used to trace the direction of ASFV isolates molecular evolution. Copyright © 2016 Elsevier B.V. All rights reserved.

Effects of neurosurgical treatment and severity of head injury on cognitive functioning, general health and incidence of mental disorders in patients with traumatic brain injury.

PubMed

Rezaei, Sajjad; Asgari, Karim; Yousefzadeh, Shahrokh; Moosavi, Heshmat-Allah; Kazemnejad, Ehsan

2012-01-01

Neurosurgical treatment and the severity of head injury (HI) can have remarkable effect on patients' neuropsychiatric outcomes. This research aimed to study the effect of these factors on cognitive functioning, general health and incidence of mental disorders in patients with a traumatic brain injury (TBI). In this descriptive, longitudinal study, 206 TBI patients entered the study by consecutive sampling; they were then compared according to neurosurgery status and severity of their HI. Both groups underwent neurosurgical and psychological examinations. The mini mental state examination (MMSE) and general health questionnaire-28 items (GHQ-28) were administered to the study participants. At follow-up, four months later, the groups underwent a structured clinical interview by a psychiatrist based on the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) diagnostic criteria regarding the presence of mental disorders. Analysis of covariance (ANCOVA) and multivariate analysis of covariance (MANCOVA) were performed and adjusted for the effect of confounding variables (age, gender, Glasgow outcome scale (GOS) , and level of education). The severity of HI had the most significant effect for the following variables; cognitive functioning and physical symptoms (P < 0.05). The effect of the neurosurgical treatment factor was not significant; however, the interaction effect of the two variables on social dysfunction, and total score of the GHQ-28 questionnaire appeared to be significant (P < 0.05). Fisher's exact test indicated that after a four month follow-up period, no significant differences were seen between the two groups (with or without neurosurgery) in the incidence of mental disorders, while χ(2) Test showed that having a more severe HI is significantly correlated with the incidence of mental disorders (P < 0.01). The implications of this study should be discussed with an emphasis on negative, effective factors on the cognitive - behavioral and neuropsychiatric outcomes of a TBI.

Adaptive developmental delay in Chagas disease vectors: an evolutionary ecology approach.

PubMed

Menu, Frédéric; Ginoux, Marine; Rajon, Etienne; Lazzari, Claudio R; Rabinovich, Jorge E

2010-05-25

The developmental time of vector insects is important in population dynamics, evolutionary biology, epidemiology and in their responses to global climatic change. In the triatomines (Triatominae, Reduviidae), vectors of Chagas disease, evolutionary ecology concepts, which may allow for a better understanding of their biology, have not been applied. Despite delay in the molting in some individuals observed in triatomines, no effort was made to explain this variability. We applied four methods: (1) an e-mail survey sent to 30 researchers with experience in triatomines, (2) a statistical description of the developmental time of eleven triatomine species, (3) a relationship between development time pattern and climatic inter-annual variability, (4) a mathematical optimization model of evolution of developmental delay (diapause). 85.6% of responses informed on prolonged developmental times in 5(th) instar nymphs, with 20 species identified with remarkable developmental delays. The developmental time analysis showed some degree of bi-modal pattern of the development time of the 5(th) instars in nine out of eleven species but no trend between development time pattern and climatic inter-annual variability was observed. Our optimization model predicts that the developmental delays could be due to an adaptive risk-spreading diapause strategy, only if survival throughout the diapause period and the probability of random occurrence of "bad" environmental conditions are sufficiently high. Developmental delay may not be a simple non-adaptive phenotypic plasticity in development time, and could be a form of adaptive diapause associated to a physiological mechanism related to the postponement of the initiation of reproduction, as an adaptation to environmental stochasticity through a spreading of risk (bet-hedging) strategy. We identify a series of parameters that can be measured in the field and laboratory to test this hypothesis. The importance of these findings is discussed in terms of global climatic change and epidemiological consequences.

Speleothem records of western Mediterranean. Hydrological variability along the Last Interglacial Period and marine linkages

NASA Astrophysics Data System (ADS)

Torner, Judit; Cacho, Isabel; Moreno, Ana; Stoll, Heather; Belmonte, Anchel; Sierro, Francisco J.; Frigola, Jaime; Martrat, Belen; Fornós, Joan; Arnau Fernández, Pedro; Hellstrom, John; Cheng, Hai; Edwards, R. Lawrence

2016-04-01

This study aims to identify and characterize regional hydrological variability in the western Mediterranean region in base to different geochemical parameters (δ18O, δ13C, and Mg/Ca ratios). Speleothems have been recovered from several caves located in southern central Pyrenees one and the others form the Balearic Islands. Their chronologies have been constructed in base on U/Th absolute dating and indicate that the speleothem sequences cover the end of the last interglacial and the glacial inception. One of the most remarkable features of the records is the intense and abrupt shift toward more arid conditions that marks the end of the last interglacial (MIS 5e). Furthermore, our speleothem records also show relatively humid but highly variable hydrological conditions during the interstadial periods from MIS 5c to 5a. These speleothem records have been compared with new generated western Mediterranean marine records from the Balearic Sea (MD99-2343) and Alboran Sea (OPD-977). Marine records include (1) proxies of sea surface temperature and changes in evaporation-precipitation rates based on pair analysis of δ18O and the Mg/Ca ratios in planktonic foraminifera Globigerina bulloides; (2) proxies of deep-water currents associated with the Western Mediterranean Deep Water (WMDW) based on grain size analyses. The results reveal that arid conditions on land were coeval with cold sea surface sub-stages (MIS 5b and 5d), and also with increases in the intensity of the WMDW-related currents. By contrast, humid and hydrological unstable atmosphere conditions were synchronous with sea surface warm sub-stages, and lower WMDW-related currents intensities (MIS 5a, c and e). Consequently, our results highly evidence a strong atmospheric-oceanic coupling, involving parallel changes in both surface but also deep western Mediterranean Sea conditions during the last interglacial period and the glacial inception.

Intra-Species Genetic Diversity and Clonal Structure of Cryptosporidium parvum in Sheep Farms in a Confined Geographical Area in Northeastern Spain.

PubMed

Ramo, Ana; Monteagudo, Luis V; Del Cacho, Emilio; Sánchez-Acedo, Caridad; Quílez, Joaquín

2016-01-01

A multilocus fragment typing approach including eleven variable-number tandem-repeat (VNTR) loci and the GP60 gene was used to investigate the intra-farm and intra-host genetic diversity of Cryptosporidium parvum in sheep farms in a confined area in northeastern Spain. Genomic DNA samples of 113 C. parvum isolates from diarrheic pre-weaned lambs collected in 49 meat-type sheep farms were analyzed. Loci exhibited various degrees of polymorphism, the finding of 7-9 alleles in the four most variable and discriminatory markers (ML2, Cgd6_5400, Cgd6_3940, and GP60) being remarkable. The combination of alleles at the twelve loci identified a total of 74 multilocus subtypes (MLTs) and provided a Hunter-Gaston discriminatory index of 0.988 (95% CI, 0.979-0.996). The finding that most MLTs (n = 64) were unique to individual farms evidenced that cryptosporidial infection is mainly transmitted within sheep flocks, with herd-to-herd transmission playing a secondary role. Limited intra- host variability was found, since only five isolates were genotypically mixed. In contrast, a significant intra-farm genetic diversity was seen, with the presence of multiple MLTs on more than a half of the farms (28/46), suggesting frequent mutations or genetic exchange through recombination. Comparison with a previous study in calves in northern Spain using the same 12-loci typing approach showed differences in the identity of major alleles at most loci, with a single MLT being shared between lambs and calves. Analysis of evolutionary descent by the algorithm eBURST indicated a high degree of genetic divergence, with over 41% MLTs appearing as singletons along with a high number of clonal complexes, most of them linking only two MLTs. Bayesian Structure analysis and F statistics also revealed the genetic remoteness of most C. parvum isolates and no ancestral population size was chosen. Linkage analysis evidenced a prevalent pattern of clonality within the parasite population.

Baseline study of the spatio-temporal patterns of reef fish assemblages prior to a major mining project in New Caledonia (South Pacific).

PubMed

Chabanet, Pascale; Guillemot, Nicolas; Kulbicki, Michel; Vigliola, Laurent; Sarramegna, Sébastien

2010-01-01

From 2008 onwards, the coral reefs of Koné (New Caledonia) will be subjected to a major anthropogenic perturbation linked to development of a nickel mine. Dredging and sediment runoff may directly damage the reef environment whereas job creation should generate a large demographic increase and thus a rise in fishing activities. This study analyzed reef fish assemblages between 2002 and 2007 with a focus on spatio-temporal variability. Our results indicate strong spatial structure of fish assemblages through time. Total species richness, density and biomass were highly variable between years but temporal variations were consistent among biotopes. A remarkable spatio-temporal stability was observed for trophic (mean 4.6% piscivores, 53.1% carnivores, 30.8% herbivores and 11.4% planktivores) and home range structures of species abundance contributions. These results are discussed and compared with others sites of the South Pacific. For monitoring perspectives, some indicators related to expected disturbances are proposed. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Effect of a Dispersant Agent in Fine Coal Recovery from Washery Tailings by Oil Agglomeration (Preliminary Study)

NASA Astrophysics Data System (ADS)

Yasar, Özüm; Uslu, Tuncay

2017-12-01

Among the fine coal cleaning methods, the oil agglomeration process has important advantages such as high process recovery, more clean product, simple dewatering stage. Several coal agglomeration studies have been undertaken recently and effects of different variables on the process performance have been investigated. However, unlike flotation studies, most of the previous agglomeration studies have not used dispersing agents to minimize slime coating effects of clays. In this study, agglomeration process was applied for recovery of fine coals from coal washery tailings containing remarkable amount of fine coal. Negative effect of fine clays during recovery was tried to be eliminated by using dispersing agent instead of de-sliming. Although ash reductions over 90 % were achieved, performance remained below expectations in terms of combustible matter recovery. However, this study is a preliminary one. It is considered that more satisfied results will be obtained in the next studies by changing the variables such as solid ratio, oil dosage, dispersant type and dosage.

Determination of the proton-to-helium ratio in cosmic rays at ultra-high energies from the tail of the Xmax distribution

NASA Astrophysics Data System (ADS)

Yushkov, A.; Risse, M.; Werner, M.; Krieg, J.

2016-12-01

We present a method to determine the proton-to-helium ratio in cosmic rays at ultra-high energies. It makes use of the exponential slope, Λ, of the tail of the Xmax distribution measured by an air shower experiment. The method is quite robust with respect to uncertainties from modeling hadronic interactions and to systematic errors on Xmax and energy, and to the possible presence of primary nuclei heavier than helium. Obtaining the proton-to-helium ratio with air shower experiments would be a remarkable achievement. To quantify the applicability of a particular mass-sensitive variable for mass composition analysis despite hadronic uncertainties we introduce as a metric the 'analysis indicator' and find an improved performance of the Λ method compared to other variables currently used in the literature. The fraction of events in the tail of the Xmax distribution can provide additional information on the presence of nuclei heavier than helium in the primary beam.

Empirical Performance of Cross-Validation With Oracle Methods in a Genomics Context

PubMed Central

Martinez, Josue G.; Carroll, Raymond J.; Müller, Samuel; Sampson, Joshua N.; Chatterjee, Nilanjan

2012-01-01

When employing model selection methods with oracle properties such as the smoothly clipped absolute deviation (SCAD) and the Adaptive Lasso, it is typical to estimate the smoothing parameter by m-fold cross-validation, for example, m = 10. In problems where the true regression function is sparse and the signals large, such cross-validation typically works well. However, in regression modeling of genomic studies involving Single Nucleotide Polymorphisms (SNP), the true regression functions, while thought to be sparse, do not have large signals. We demonstrate empirically that in such problems, the number of selected variables using SCAD and the Adaptive Lasso, with 10-fold cross-validation, is a random variable that has considerable and surprising variation. Similar remarks apply to non-oracle methods such as the Lasso. Our study strongly questions the suitability of performing only a single run of m-fold cross-validation with any oracle method, and not just the SCAD and Adaptive Lasso. PMID:22347720

From mild ataxia to huntington disease phenocopy: the multiple faces of spinocerebellar ataxia 17.

PubMed

Koutsis, Georgios; Panas, Marios; Paraskevas, George P; Bougea, Anastasia M; Kladi, Athina; Karadima, Georgia; Kapaki, Elisabeth

2014-01-01

Introduction. Spinocerebellar ataxia 17 (SCA 17) is a rare autosomal dominant cerebellar ataxia (ADCA) caused by a CAG/CAA expansion in the TBP gene, reported from a limited number of countries. It is a very heterogeneous ADCA characterized by ataxia, cognitive decline, psychiatric symptoms, and involuntary movements, with some patients presenting with Huntington disease (HD) phenocopies. The SCA 17 expansion is stable during parent-child transmission and intrafamilial phenotypic homogeneity has been reported. However, significant phenotypic variability within families has also been observed. Report of the Family. We presently report a Greek family with a pathological expansion of 54 repeats at the SCA 17 locus that displayed remarkable phenotypic variability. Among 3 affected members, one presented with HD phenocopy; one with progressive ataxia, dementia, chorea, dystonia, and seizures, and one with mild slowly progressive ataxia with minor cognitive and affective symptoms. Conclusions. This is the first family with SCA 17 identified in Greece and highlights the multiple faces of this rare disorder, even within the same family.

From Mild Ataxia to Huntington Disease Phenocopy: The Multiple Faces of Spinocerebellar Ataxia 17

PubMed Central

Panas, Marios; Paraskevas, George P.; Bougea, Anastasia M.; Karadima, Georgia; Kapaki, Elisabeth

2014-01-01

Introduction. Spinocerebellar ataxia 17 (SCA 17) is a rare autosomal dominant cerebellar ataxia (ADCA) caused by a CAG/CAA expansion in the TBP gene, reported from a limited number of countries. It is a very heterogeneous ADCA characterized by ataxia, cognitive decline, psychiatric symptoms, and involuntary movements, with some patients presenting with Huntington disease (HD) phenocopies. The SCA 17 expansion is stable during parent-child transmission and intrafamilial phenotypic homogeneity has been reported. However, significant phenotypic variability within families has also been observed. Report of the Family. We presently report a Greek family with a pathological expansion of 54 repeats at the SCA 17 locus that displayed remarkable phenotypic variability. Among 3 affected members, one presented with HD phenocopy; one with progressive ataxia, dementia, chorea, dystonia, and seizures, and one with mild slowly progressive ataxia with minor cognitive and affective symptoms. Conclusions. This is the first family with SCA 17 identified in Greece and highlights the multiple faces of this rare disorder, even within the same family. PMID:25349749

The effect of artificial selection on phenotypic plasticity in maize.

PubMed

Gage, Joseph L; Jarquin, Diego; Romay, Cinta; Lorenz, Aaron; Buckler, Edward S; Kaeppler, Shawn; Alkhalifah, Naser; Bohn, Martin; Campbell, Darwin A; Edwards, Jode; Ertl, David; Flint-Garcia, Sherry; Gardiner, Jack; Good, Byron; Hirsch, Candice N; Holland, Jim; Hooker, David C; Knoll, Joseph; Kolkman, Judith; Kruger, Greg; Lauter, Nick; Lawrence-Dill, Carolyn J; Lee, Elizabeth; Lynch, Jonathan; Murray, Seth C; Nelson, Rebecca; Petzoldt, Jane; Rocheford, Torbert; Schnable, James; Schnable, Patrick S; Scully, Brian; Smith, Margaret; Springer, Nathan M; Srinivasan, Srikant; Walton, Renee; Weldekidan, Teclemariam; Wisser, Randall J; Xu, Wenwei; Yu, Jianming; de Leon, Natalia

2017-11-07

Remarkable productivity has been achieved in crop species through artificial selection and adaptation to modern agronomic practices. Whether intensive selection has changed the ability of improved cultivars to maintain high productivity across variable environments is unknown. Understanding the genetic control of phenotypic plasticity and genotype by environment (G × E) interaction will enhance crop performance predictions across diverse environments. Here we use data generated from the Genomes to Fields (G2F) Maize G × E project to assess the effect of selection on G × E variation and characterize polymorphisms associated with plasticity. Genomic regions putatively selected during modern temperate maize breeding explain less variability for yield G × E than unselected regions, indicating that improvement by breeding may have reduced G × E of modern temperate cultivars. Trends in genomic position of variants associated with stability reveal fewer genic associations and enrichment of variants 0-5000 base pairs upstream of genes, hypothetically due to control of plasticity by short-range regulatory elements.

Surveillance data for waterborne illness detection: an assessment following a massive waterborne outbreak of Cryptosporidium infection.

PubMed Central

Proctor, M. E.; Blair, K. A.; Davis, J. P.

1998-01-01

Following the 1993 Milwaukee cryptosporidiosis outbreak, we examined data from eight sources available during the time of the outbreak. Although there was a remarkable temporal correspondence of surveillance peaks, the most timely data involved use of systems in which personnel with existing close ties to public health programmes perceived the importance of providing information despite workload constraints associated with an outbreak. During the investigation, surveillance systems which could be easily linked with laboratory data, were flexible in adding new variables, and which demonstrated low baseline variability were most useful. Geographically fixed nursing home residents served as an ideal population with nonconfounded exposures. Use of surrogate measurements of morbidity can trigger worthwhile public health responses in advance of laboratory-confirmed diagnosis and help reduce total morbidity associated with an outbreak. This report describes the relative strengths and weaknesses of these surveillance methods for community-wide waterborne illness detection and their application in outbreak decision making. PMID:9528817

Effects of Weight Reduction After Sleeve Gastrectomy on Metabolic Variables in Saudi Obese Subjects in Aseer Province of Kingdom of Saudi Arabia.

PubMed

Bawahab, Mohammed A; Assiri, Abdullah S; Maksoud, Walid Abdel; Patel, Ayyub; Kadoumi, Osama; Zaman, Gaffar Sarwar; Alessih, Riyad Mohammed Khalil; Haider, Syed Saleem

2017-08-01

The objectives of this study were to investigate the occurrence of oxidative stress, status of protective antioxidants enzymes, inflammatory biomarkers, and some metabolic health variables in the blood and to compare the results between those of the normal controls and obese patients submitted to sleeve gastrectomy-induced weight loss over a 1-year follow-up period. A prospective study was conducted in Aseer Central Hospital and Abha Private Hospital in the Kingdom of Saudi Arabia from January 2012 to January 2013 on 50 normal (BMI = 22-25 kg/m 2 ) control subjects and 50 obese (BMI = 45-50 kg/m 2 ) patients. A subset of 20 men and 80 women patients, aged 20-45 years, was included. The systemic blood cell counts were determined by Beckman Coulter UniCel analyzer. The occurrence of oxidative stress, the status of antioxidant enzyme system in the blood, levels of serum hepatic enzymes, cardiovascular risk factors, and serum sodium, potassium, copper, and zinc levels were determined by spectrophotometric procedures. The concentration of TSH and T 4 were analyzed by Siemens Immunoassay System. Group 1 (Obese: preoperative) This group compared with the normal controls exhibited significant (p < 0.05) increase in inflammatory biomarkers, a significant (p < 0.05) rise in hepatic enzymes, a significant (p < 0.05) decrease in serum total bilirubin. Concentration of serum total cholesterol (TC), triacylglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose(FBG) were significantly (p < 0.05) increased, but HDL cholesterol (HDL-C) was significantly depleted (p < 0.05). Serum urea and creatinine contents were significantly (p < 0.05) decreased. Serum copper and zinc levels were significantly (p < 0.05) increased. Group 2: Sleeve Gastrectomy Surgery (Obese: postoperative) This group compared with the obese group, preoperatively, demonstrated a profound reduction in body weight (-32%) as well as in BMI (-29%). Serum malondialdehyde, a stress index, was significantly (p < 0.001) inhibited and conversely, activities of antioxidant enzymes: superoxide dismutase(Cu-Zn SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glucose-6-phosphate dehydrogenase (G6PDH), and vitamin C, were remarkably (p < 0.001) increased. Furthermore, remarkable improvements in deranged metabolic variables approaching normality were discernible. Inflammatory biomarkers in the blood and hepatic enzymes in serum were significantly (p < 0.001) decreased. Levels of TC, TG, LDL-C, FBG, and HDL-C in serum exhibited significant (p < 0.05) reductions, a reversal toward normality. Serum albumin and total bilirubin concentrations were significantly increased (p < 0.001). Serum sodium, potassium, copper, zinc, and TSH levels were significantly (p < 0.001) decreased. Obesity is a chronic disease of multifactorial origin and resulted in perturbations of whole body metabolism in this study. It is thus likely that this imbalance was associated with an inhibition in protective antioxidants and occurrence of oxidative stress. The staging concept of sleeve gastrectomy is a safe and effective approach with remarkable efficacy in sustaining weight loss and bringing back normal metabolism of variables in tissues over a 1-year follow-up period.

Coevolutionary modeling of protein sequences: Predicting structure, function, and mutational landscapes

NASA Astrophysics Data System (ADS)

Weigt, Martin

Over the last years, biological research has been revolutionized by experimental high-throughput techniques, in particular by next-generation sequencing technology. Unprecedented amounts of data are accumulating, and there is a growing request for computational methods unveiling the information hidden in raw data, thereby increasing our understanding of complex biological systems. Statistical-physics models based on the maximum-entropy principle have, in the last few years, played an important role in this context. To give a specific example, proteins and many non-coding RNA show a remarkable degree of structural and functional conservation in the course of evolution, despite a large variability in amino acid sequences. We have developed a statistical-mechanics inspired inference approach - called Direct-Coupling Analysis - to link this sequence variability (easy to observe in sequence alignments, which are available in public sequence databases) to bio-molecular structure and function. In my presentation I will show, how this methodology can be used (i) to infer contacts between residues and thus to guide tertiary and quaternary protein structure prediction and RNA structure prediction, (ii) to discriminate interacting from non-interacting protein families, and thus to infer conserved protein-protein interaction networks, and (iii) to reconstruct mutational landscapes and thus to predict the phenotypic effect of mutations. References [1] M. Figliuzzi, H. Jacquier, A. Schug, O. Tenaillon and M. Weigt ''Coevolutionary landscape inference and the context-dependence of mutations in beta-lactamase TEM-1'', Mol. Biol. Evol. (2015), doi: 10.1093/molbev/msv211 [2] E. De Leonardis, B. Lutz, S. Ratz, S. Cocco, R. Monasson, A. Schug, M. Weigt ''Direct-Coupling Analysis of nucleotide coevolution facilitates RNA secondary and tertiary structure prediction'', Nucleic Acids Research (2015), doi: 10.1093/nar/gkv932 [3] F. Morcos, A. Pagnani, B. Lunt, A. Bertolino, D. Marks, C. Sander, R. Zecchina, J.N. Onuchic, T. Hwa, M. Weigt, ''Direct-coupling analysis of residue co-evolution captures native contacts across many protein families'', Proc. Natl. Acad. Sci. 108, E1293-E1301 (2011).

How broad and deep is the region of chemical alteration of oceanic plates at trenches?

NASA Astrophysics Data System (ADS)

Ranero, C. R.; Grevemeyer, I.; Barckhausen, U.

2017-12-01

Different lines of evidence indicate that oceanic plates are affected by pervasive bending-related deformation approaching ocean trenches. Results from active-seismic work support that deformation provides paths for exchange between hydrosphere and lithosphere, possibly causing chemical alteration of the incoming lithosphere. Much work focused on the potential transformation of peridotite to serpentine in the uppermost mantle of incoming plates, but there is no consensus on the region where it may occur or the intensity of alteration, let alone on limiting factors for the process. Teleseismic (large-great) earthquakes with normal-fault mechanism in the outer rise region have been often called to speculate on the depth of penetration of plate hydration. However, large-great outer-rise earthquakes may be related to stress changes due to slab pull after decoupling along the inter-plate boundary, and not necessarily controlled by bending stresses only. If so, the majority of the time the depth of water percolation may be related to local bending stresses expressed by micro-earthquakes rather than large events. Seismic images and multibeam bathymetry from lithosphere of similar thermal thickness from different trenches display a remarkable variability of the intensity of bending-related deformation along the subduction zones where plate age does not change significantly indicating that the intensity of deformation (not the depth) and perhaps hydration is very variable in space and not controlled by plate age. Seismic images showing hundreds of kilometers perpendicular to the trench into the incoming plate show that the bending-related deformation reaches mantle under the outer rise, well before the lithosphere plunges into the trench and develops the marked bend-faulting fabric observable in bathymetric maps. Thus, alteration occurs in a hundreds-of-km wide area, with deformation intensity related to local characteristics, and deformation depth to plate age.

X-ray spectral analysis of the steady states of GRS 1915+105

NASA Astrophysics Data System (ADS)

Peris, Charith; Remillard, Ronald A.; Steiner, James F.; Vrtilek, Saeqa Dil; Varniere, Peggy; Rodriguez, Jerome; Pooley, Guy G.

2016-04-01

Of the black hole binaries (BHBs) discovered thus far, GRS 1915+105 stands out as an exceptional source primarily due to its wild X-ray variability, the diversity of which has not been replicated in any other stellar-mass black hole. Although extreme variability is commonplace in its light-curve, about half of the observations of GRS1915+105 show fairly steady X-ray intensity. We report on the X-ray spectral behavior within these steady observations. Our work is based on a vast RXTE/PCA data set obtained on GRS 1915+105 during the course of its entire mission and 10 years of radio data from the Ryle Telescope, which overlap the X-ray data. We find that the steady observations within the X-ray data set naturally separate into two regions in a color-color diagram, which we refer to as steady-soft and steady-hard. GRS 1915+105 displays significant curvature in the Comptonization component within the PCA band pass suggesting significantly heating from a hot disk present in all states. A new Comptonization model 'simplcut' was developed in order to model this curvature to best effect. A majority of the steady-soft observations display a roughly constant inner disk radius, remarkably reminiscent of canonical soft state black hole binaries. In contrast, the steady-hard observations display a growing disk truncation that is correlated to the mass accretion rate through the disk, which suggests a magnetically truncated disk. A comparison of X-ray model parameters to the canonical state definitions show that almost all steady-soft observations match the criteria of either thermal or steep power law state, while the thermal state observations dominate the constant radius branch. A large portion 80 % of the steady-hard observations matches the hard state criteria when the disk fraction constraint is neglected. These results combine to suggest that within the complexity of this source is a simpler underlying basis of states, which map to those observed in canonical BHBs.

Extreme Variables in Star Forming Regions

NASA Astrophysics Data System (ADS)

Contreras Peña, Carlos Eduardo

2015-01-01

The notion that low- to intermediate-mass young stellar objects (YSOs) gain mass at a constant rate during the early stages of their evolution appears to be challenged by observations of YSOs suffering sudden increases of the rate at which they gain mass from their circumstellar discs. Also, this idea that stars spend most of their lifetime with a low accretion rate and gain most of their final mass during short-lived episodes of high accretion bursts, helps to solve some long-standing problems in stellar evolution. The original classification of eruptive variables divides them in two separate subclasses known as FU Orionis stars (FUors) and EX Lupi stars (EXors). In this classical view FUors are at an early evolutionary stage and are still gaining mass from their parent envelopes, whilst EXors are thought to be older objects only surrounded by an accretion disc. The problem with this classical view is that it excludes younger protostars which have higher accretion rates but are too deeply embedded in circumstellar matter to be observed at optical wavelengths. Optically invisible protostars have been observed to display large variability in the near-infrared. These and some recent discoveries of new eruptive variables, show characteristics that can be attributed to both of the optically-defined subclasses of eruptive variables. The new objects have been proposed to be part of a new class of eruptive variables. However, a more accepted scenario is that in fact the original classes only represent two extremes of the same phenomena. In this sense eruptive variability could be explained as arising from one physical mechanism, i.e. unsteady accretion, where a variation in the parameters of such mechanism can cause the different characteristics observed in the members of this class. With the aim of studying the incidence of episodic accretion among young stellar objects, and to characterize the nature of these eruptive variables we searched for high amplitude variability in two multi-epoch infrared surveys: the UKIDSS Galactic Plane Survey (GPS) and the Vista Variables in the Via Lactea (VVV). In order to further investigate the nature of the selected variable stars, we use photometric information arising from public surveys at near- to far-infrared wavelengths. In addition we have performed spectroscopic and photometric follow-up for a large subset of the samples arising from GPS and VVV. We analyse the widely separated two-epoch K-band photometry in the 5th, 7th and 8th data releases of the UKIDSS Galactic Plane Survey. We find 71 stars with ΔK > 1 mag, including 2 previously known OH/IR stars and a Nova. Even though the mid-plane is mostly excluded from the dataset, we find the majority (66%) of our sample to be within known star forming regions (SFRs), with two large concentrations in the Serpens OB2 association (11 stars) and the Cygnus-X complex (27 stars). The analysis of the multi-epoch K-band photometry of 2010-2012 data from VVV covering the Galactic disc at |b| < 1° yields 816 high amplitude variables, which include known variables of different classes such as high mass X-ray binaries, Novae and eclipsing binaries among others. Remarkably, 65% of the sample are found concentrated towards areas of star formation, similar to the results from GPS. In both surveys, sources in SFRs show spectral energy distributions (SEDs) that support classification as YSOs. This indicates that YSOs dominate the Galactic population of high amplitude infrared variable stars at low luminosities and therefore likely dominate the total high amplitude population. Spectroscopic follow-up allows us to confirm the pre-main sequence nature of several GPS and VVV Objects. Most objects in both samples show spectroscopic signatures that can be attributed to YSOs undergoing high states of accretion, such as veiling of photospheric features and CO emission, or show FUor-like spectra. We also find a large fraction of objects with 2.12 μm H2 emission that can be explained as arising from shock-excited emission caused by molecular outflows. Whether these molecular outflows are related to outbursts events cannot be confirmed from our data. Adding the GPS and VVV spectroscopic results, we find that between 6 and 14 objects are new additions to the FUor class from their close resemblance to the near-infrared spectra of FUors, and at least 23 more objects are new additions to the eruptive variable class. For most of these we are unable to classify them into any of the original definitions for this variable class. In any case, we are adding up to 37 new stars to the eruptive variable class which would double the current number of known objects. We note that most objects are found to be deeply embedded optically invisible stars, thus increasing the number of objects belonging to this subclass by a much larger factor. In general, objects in our samples which are found to be likely eruptive variable stars show a mixture of characteristics that can be attributed to both of the optically-defined classes. This agrees well with the recent discoveries in the literature. Finally, we are able to derive a first rough estimate on the incidence of episodic accretion among class I YSOs in the star-forming complex G305. We find that ~9% of such objects are in a state of high accretion. This number is in agreement with previous theoretical and observational estimates among class I YSOs.

Modelling Escherichia coli concentrations in the tidal Scheldt river and estuary.

PubMed

de Brauwere, Anouk; de Brye, Benjamin; Servais, Pierre; Passerat, Julien; Deleersnijder, Eric

2011-04-01

Recent observations in the tidal Scheldt River and Estuary revealed a poor microbiological water quality and substantial variability of this quality which can hardly be assigned to a single factor. To assess the importance of tides, river discharge, point sources, upstream concentrations, mortality and settling a new model (SLIM-EC) was built. This model was first validated by comparison with the available field measurements of Escherichia coli (E. coli, a common fecal bacterial indicator) concentrations. The model simulations agreed well with the observations, and in particular were able to reproduce the observed long-term median concentrations and variability. Next, the model was used to perform sensitivity runs in which one process/forcing was removed at a time. These simulations revealed that the tide, upstream concentrations and the mortality process are the primary factors controlling the long-term median E. coli concentrations and the observed variability. The tide is crucial to explain the increased concentrations upstream of important inputs, as well as a generally increased variability. Remarkably, the wastewater treatment plants discharging in the study domain do not seem to have a significant impact. This is due to a dilution effect, and to the fact that the concentrations coming from upstream (where large cities are located) are high. Overall, the settling process as it is presently described in the model does not significantly affect the simulated E. coli concentrations. Copyright © 2011 Elsevier Ltd. All rights reserved.

Can basin land use effects on physical characteristics of streams be determined at broad geographic scales?

USGS Publications Warehouse

Goldstein, R.M.; Carlisle, D.M.; Meador, M.R.; Short, T.M.

2007-01-01

The environmental setting (e.g., climate, topography, geology) and land use affect stream physical characteristics singly and cumulatively. At broad geographic scales, we determined the importance of environmental setting and land use in explaining variation in stream physical characteristics. We hypothesized that as the spatial scale decreased from national to regional, land use would explain more of the variation in stream physical characteristics because environmental settings become more homogeneous. At a national scale, stepwise linear regression indicated that environmental setting was more important in explaining variability in stream physical characteristics. Although statistically discernible, the amount of variation explained by land use was not remarkable due to low partial correlations. At level II ecoregion spatial scales (southeastern USA plains, central USA plains, and a combination of the western Cordillera and the western interior basins and ranges), environmental setting variables were again more important predictors of stream physical characteristics, however, as the spatial scale decreased from national to regional, the portion of variability in stream physical characteristics explained by basin land use increased. Development of stream habitat indicators of land use will depend upon an understanding of relations between stream physical characteristics and environmental factors at multiple spatial scales. Smaller spatial scales will be necessary to reduce the confounding effects of variable environmental settings before the effects of land use can be reliably assessed. ?? Springer Science+Business Media B.V. 2006.

Vocal exploration is locally regulated during song learning

PubMed Central

Ravbar, Primoz; Parra, Lucas C.; Lipkind, Dina; Tchernichovski, Ofer

2012-01-01

Exploratory variability is essential for sensory-motor learning, but it is not known how and at what time scales it is regulated. We manipulated song learning in zebra finches to experimentally control the requirements for vocal exploration in different parts of their song. We first trained birds to perform a one-syllable song, and once they mastered it we added a new syllable to the song model. Remarkably, when practicing the modified song, birds rapidly alternated between high and low acoustic variability to confine vocal exploration to the newly added syllable. Further, even within syllables, acoustic variability changed independently across song elements that were only milliseconds apart. Analysis of the entire vocal output during learning revealed that the variability of each song element decreased as it approached the target, correlating with momentary local distance from the target and less so with the overall distance. We conclude that vocal error is computed locally in sub-syllabic time scales and that song elements can be learned and crystalized independently. Songbirds have dedicated brain circuitry for vocal babbling in the anterior forebrain pathway (AFP), which generates exploratory song patterns that drive premotor neurons at the song nucleus RA (robust nucleus of the arcopallium). We hypothesize that either AFP adjusts the gain of vocal exploration in fine time scales, or that the sensitivity of RA premotor neurons to AFP/HVC inputs varies across song elements. PMID:22399765

Intraspecific venom variation in the medically significant Southern Pacific Rattlesnake (Crotalus oreganus helleri): biodiscovery, clinical and evolutionary implications.

PubMed

Sunagar, Kartik; Undheim, Eivind A B; Scheib, Holger; Gren, Eric C K; Cochran, Chip; Person, Carl E; Koludarov, Ivan; Kelln, Wayne; Hayes, William K; King, Glenn F; Antunes, Agosthino; Fry, Bryan Grieg

2014-03-17

Due to the extreme variation of venom, which consequently results in drastically variable degrees of neutralization by CroFab antivenom, the management and treatment of envenoming by Crotalus oreganus helleri (the Southern Pacific Rattlesnake), one of the most medically significant snake species in all of North America, has been a clinician's nightmare. This snake has also been the subject of sensational news stories regarding supposed rapid (within the last few decades) evolution of its venom. This research demonstrates for the first time that variable evolutionary selection pressures sculpt the intraspecific molecular diversity of venom components in C. o. helleri. We show that myotoxic β-defensin peptides (aka: crotamines/small basic myotoxic peptides) are secreted in large amounts by all populations. However, the mature toxin-encoding nucleotide regions evolve under the constraints of negative selection, likely as a result of their non-specific mode of action which doesn't enforce them to follow the regime of the classic predator-prey chemical arms race. The hemorrhagic and tissue destroying snake venom metalloproteinases (SVMPs) were secreted in larger amounts by the Catalina Island and Phelan rattlesnake populations, in moderate amounts in the Loma Linda population and in only trace levels by the Idyllwild population. Only the Idyllwild population in the San Jacinto Mountains contained potent presynaptic neurotoxic phospholipase A2 complex characteristic of Mohave Rattlesnake (Crotalus scutulatus) and Neotropical Rattlesnake (Crotalus durissus terrificus). The derived heterodimeric lectin toxins characteristic of viper venoms, which exhibit a diversity of biological activities, including anticoagulation, agonism/antagonism of platelet activation, or procoagulation, appear to have evolved under extremely variable selection pressures. While most lectin α- and β-chains evolved rapidly under the influence of positive Darwinian selection, the β-chain lectin of the Catalina Island population appears to have evolved under the constraint of negative selection. Both lectin chains were conspicuously absent in both the proteomics and transcriptomics of the Idyllwild population. Thus, we not only highlight the tremendous biochemical diversity in C. o. helleri's venom-arsenal, but we also show that they experience remarkably variable strengths of evolutionary selection pressures, within each toxin class among populations and among toxin classes within each population. The mapping of geographical venom variation not only provides additional information regarding venom evolution, but also has direct medical implications by allowing prediction of the clinical effects of rattlesnake bites from different regions. Such information, however, also points to these highly variable venoms as being a rich source of novel toxins which may ultimately prove to be useful in drug design and development. These results have direct implications for the treatment of envenomed patients. The variable venom profile of Crotalus oreganus helleri underscores the biodiscovery potential of novel snake venoms. Copyright © 2014 Elsevier B.V. All rights reserved.

Spontaneous Number Representation in Mosquitofish

ERIC Educational Resources Information Center

Dadda, Marco; Piffer, Laura; Agrillo, Christian; Bisazza, Angelo

2009-01-01

While there is convincing evidence that preverbal human infants and non-human primates can spontaneously represent number, considerable debate surrounds the possibility that such capacity is also present in other animals. Fish show a remarkable ability to discriminate between different numbers of social companions. Previous work has demonstrated…

Mesoscopic Perovskite Light-Emitting Diodes.

PubMed

Palma, Alessandro Lorenzo; Cinà, Lucio; Busby, Yan; Marsella, Andrea; Agresti, Antonio; Pescetelli, Sara; Pireaux, Jean-Jacques; Di Carlo, Aldo

2016-10-03

Solution-processed hybrid bromide perovskite light-emitting-diodes (PLEDs) represent an attractive alternative technology that would allow overcoming the well-known severe efficiency drop in the green spectrum related to conventional LEDs technologies. In this work, we report on the development and characterization of PLEDs fabricated using, for the first time, a mesostructured layout. Stability of PLEDs is a critical issue; remarkably, mesostructured PLEDs devices tested in ambient conditions and without encapsulation showed a lifetime well-above what previously reported with a planar heterojunction layout. Moreover, mesostructured PLEDs measured under full operative conditions showed a remarkably narrow emission spectrum, even lower than what is typically obtained by nitride- or phosphide-based green LEDs. A dynamic analysis has shown fast rise and fall times, demonstrating the suitability of PLEDs for display applications. Combined electrical and advanced structural analyses (Raman, XPS depth profiling, and ToF-SIMS 3D analysis) have been performed to elucidate the degradation mechanism, the results of which are mainly related to the degradation of the hole-transporting material (HTM) and to the perovskite-HTM interface.