Science.gov

Sample records for sigact acm sigarch

  1. Acme jumper pipe

    SciTech Connect

    Medved, P.; Thomas, H.

    1995-09-01

    Acme Steel had operated the larry car with an attached jumper pipe since 1977. Acme had been able to meet the State Implementation Plan. With the advent of the Clean Air Act, Acme did not feel it could meet these new standards without some modifications to the jumper pipe system. Several drop sleeve modifications and numerous boot seal materials and configurations were tested that resulted in limited success in improving the boot seal life. After these modifications, Acme`s testing revealed it could meet the Clean Air Act standards, but it would be cost prohibitive to continue to operate in this manner. Following extensive investigation, Acme decided to install an off-car jumper pipe system which uses a traveling U-tube for connecting to the assist oven through an additional hole in each oven roof. Temperature related failures of drop sleeve seals were eliminated. The off-car jumper pipe is a more efficient gas connection to the assist oven and enables Acme to meet the Clean Air Act charging requirements in a cost effective manner.

  2. ACME-III and ACME-IV Final Campaign Reports

    SciTech Connect

    Biraud, S. C.

    2016-01-01

    The goals of the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s third and fourth Airborne Carbon Measurements (ACME) field campaigns, ACME-III and ACME-IV, are: 1) to measure and model the exchange of CO2, water vapor, and other greenhouse gases by the natural, agricultural, and industrial ecosystems of the Southern Great Plains (SGP) region; 2) to develop quantitative approaches to relate these local fluxes to the concentration of greenhouse gases measured at the Central Facility tower and in the atmospheric column above the ARM SGP Central Facility, 3) to develop and test bottom-up measurement and modeling approaches to estimate regional scale carbon balances, and 4) to develop and test inverse modeling approaches to estimate regional scale carbon balance and anthropogenic sources over continental regions. Regular soundings of the atmosphere from near the surface into the mid-troposphere are essential for this research.

  3. ACME: A Basis for Architecture Exchange

    DTIC Science & Technology

    2003-12-01

    representation of Acme in an internal study, which later matured to be known as ADML (see http://xml.coverpages.org/adml.html). David Wile...interchange medium to enable inter-ADL tool use. The growth of xAcme and ADML indicates significant web usage. • Provide a base level ADL to be

  4. Asbestos-Containing Materials (ACM) and Demolition

    EPA Pesticide Factsheets

    There are specific federal regulatory requirements that require the identification of asbestos-containing materials (ACM) in many of the residential buildings that are being demolished or renovated by a municipality.

  5. Quark ACM with topologically generated gluon mass

    NASA Astrophysics Data System (ADS)

    Choudhury, Ishita Dutta; Lahiri, Amitabha

    2016-03-01

    We investigate the effect of a small, gauge-invariant mass of the gluon on the anomalous chromomagnetic moment (ACM) of quarks by perturbative calculations at one-loop level. The mass of the gluon is taken to have been generated via a topological mass generation mechanism, in which the gluon acquires a mass through its interaction with an antisymmetric tensor field Bμν. For a small gluon mass ( < 10 MeV), we calculate the ACM at momentum transfer q2 = -M Z2. We compare those with the ACM calculated for the gluon mass arising from a Proca mass term. We find that the ACM of up, down, strange and charm quarks vary significantly with the gluon mass, while the ACM of top and bottom quarks show negligible gluon mass dependence. The mechanism of gluon mass generation is most important for the strange quarks ACM, but not so much for the other quarks. We also show the results at q2 = -m t2. We find that the dependence on gluon mass at q2 = -m t2 is much less than at q2 = -M Z2 for all quarks.

  6. Additive Construction with Mobile Emplacement (ACME)

    NASA Technical Reports Server (NTRS)

    Vickers, John

    2015-01-01

    The Additive Construction with Mobile Emplacement (ACME) project is developing technology to build structures on planetary surfaces using in-situ resources. The project focuses on the construction of both 2D (landing pads, roads, and structure foundations) and 3D (habitats, garages, radiation shelters, and other structures) infrastructure needs for planetary surface missions. The ACME project seeks to raise the Technology Readiness Level (TRL) of two components needed for planetary surface habitation and exploration: 3D additive construction (e.g., contour crafting), and excavation and handling technologies (to effectively and continuously produce in-situ feedstock). Additionally, the ACME project supports the research and development of new materials for planetary surface construction, with the goal of reducing the amount of material to be launched from Earth.

  7. ACM TOMS replicated computational results initiative

    DOE PAGES

    Heroux, Michael Allen

    2015-06-03

    In this study, the scientific community relies on the peer review process for assuring the quality of published material, the goal of which is to build a body of work we can trust. Computational journals such as The ACM Transactions on Mathematical Software (TOMS) use this process for rigorously promoting the clarity and completeness of content, and citation of prior work. At the same time, it is unusual to independently confirm computational results.

  8. ACM TOMS replicated computational results initiative

    SciTech Connect

    Heroux, Michael Allen

    2015-06-03

    In this study, the scientific community relies on the peer review process for assuring the quality of published material, the goal of which is to build a body of work we can trust. Computational journals such as The ACM Transactions on Mathematical Software (TOMS) use this process for rigorously promoting the clarity and completeness of content, and citation of prior work. At the same time, it is unusual to independently confirm computational results.

  9. Porcine bladder acellular matrix (ACM): protein expression, mechanical properties.

    PubMed

    Farhat, Walid A; Chen, Jun; Haig, Jennifer; Antoon, Roula; Litman, Jessica; Sherman, Christopher; Derwin, Kathleen; Yeger, Herman

    2008-06-01

    Experimentally, porcine bladder acellular matrix (ACM) that mimics extracellular matrix has excellent potential as a bladder substitute. Herein we investigated the spatial localization and expression of different key cellular and extracellular proteins in the ACM; furthermore, we evaluated the inherent mechanical properties of the resultant ACM prior to implantation. Using a proprietary decellularization method, the DNA contents in both ACM and normal bladder were measured; in addition we used immunohistochemistry and western blots to quantify and localize the different cellular and extracellular components, and finally the mechanical testing was performed using a uniaxial mechanical testing machine. The mean DNA content in the ACM was significantly lower in the ACM compared to the bladder. Furthermore, the immunohistochemical and western blot analyses showed that collagen I and IV were preserved in the ACM, but possibly denatured collagen III in the ACM. Furthermore, elastin, laminin and fibronectin were mildly reduced in the ACM. Although the ACM did not exhibit nucleated cells, residual cellular components (actin, myosin, vimentin and others) were still present. There was, on the other hand, no significant difference in the mean stiffness between the ACM and the bladder. Although our decellularization method is effective in removing nuclear material from the bladder while maintaining its inherent mechanical properties, further work is mandatory to determine whether these residual DNA and cellular remnants would lead to any immune reaction, or if the mechanical properties of the ACM are preserved upon implantation and cellularization.

  10. Porosity of porcine bladder acellular matrix: impact of ACM thickness.

    PubMed

    Farhat, Walid; Chen, Jun; Erdeljan, Petar; Shemtov, Oren; Courtman, David; Khoury, Antoine; Yeger, Herman

    2003-12-01

    The objectives of this study are to examine the porosity of bladder acellular matrix (ACM) using deionized (DI) water as the model fluid and dextran as the indicator macromolecule, and to correlate the porosity to the ACM thickness. Porcine urinary bladders from pigs weighing 20-50 kg were sequentially extracted in detergent containing solutions, and to modify the ACM thickness, stretched bladders were acellularized in the same manner. Luminal and abluminal ACM specimens were subjected to fixed static DI water pressure (10 cm); and water passing through the specimens was collected at specific time interval. While for the macromolecule porosity testing, the diffusion rate and direction of 10,000 MW fluoroescein-labeled dextrans across the ACM specimens mounted in Ussing's chambers were measured. Both experiments were repeated on the thin stretched ACM. In both ACM types, the fluid porosity in both directions did not decrease with increased test duration (3 h); in addition, the abluminal surface was more porous to fluid than the luminal surface. On the other hand, when comparing thin to thick ACM, the porosity in either direction was higher in the thick ACM. Macromolecule porosity, as measured by absorbance, was higher for the abluminal thick ACM than the luminal side, but this characteristic was reversed in the thin ACM. Comparing thin to thick ACM, the luminal side in the thin ACM was more porous to dextran than in the thick ACM, but this characteristic was reversed for the abluminal side. The porcine bladder ACM possesses directional porosity and acellularizing stretched urinary bladders may increase structural density and alter fluid and macromolecule porosity.

  11. How to recycle asbestos containing materials (ACM)

    SciTech Connect

    Jantzen, C.M.

    2000-04-11

    The current disposal of asbestos containing materials (ACM) in the private sector consists of sealing asbestos wetted with water in plastic for safe transportation and burial in regulated land fills. This disposal methodology requires large disposal volumes especially for asbestos covered pipe and asbestos/fiberglass adhering to metal framework, e.g. filters. This wrap and bury technology precludes recycle of the asbestos, the pipe and/or the metal frameworks. Safe disposal of ACM at U.S. Department of Energy (DOE) sites, likewise, requires large disposal volumes in landfills for non-radioactive ACM and large disposal volumes in radioactive burial grounds for radioactive and suspect contaminated ACM. The availability of regulated disposal sites is rapidly diminishing causing recycle to be a more attractive option. Asbestos adhering to metal (e.g., pipes) can be recycled by safely removing the asbestos from the metal in a patented hot caustic bath which prevents airborne contamination /inhalation of asbestos fibers. The dissolution residue (caustic and asbestos) can be wet slurry fed to a melter and vitrified into a glass or glass-ceramic. Palex glasses, which are commercially manufactured, are shown to be preferred over conventional borosilicate glasses. The Palex glasses are alkali magnesium silicate glasses derived by substituting MgO for B{sub 2}O{sub 3} in borosilicate type glasses. Palex glasses are very tolerant of the high MgO and high CaO content of the fillers used in forming asbestos coverings for pipes and found in boiler lashing, e.g., hydromagnesite (3MgCO{sub 3} Mg(OH){sub 2} 3H{sub 2}O) and plaster of paris, gypsum (CaSO{sub 4}). The high temperate of the vitrification process destroys the asbestos fibers and renders the asbestos non-hazardous, e.g., a glass or glass-ceramic. In this manner the glass or glass-ceramic produced can be recycled, e.g., glassphalt or glasscrete, as can the clean metal pipe or metal framework.

  12. AcmD, a Homolog of the Major Autolysin AcmA of Lactococcus lactis, Binds to the Cell Wall and Contributes to Cell Separation and Autolysis

    PubMed Central

    Visweswaran, Ganesh Ram R.; Steen, Anton; Leenhouts, Kees; Szeliga, Monika; Ruban, Beata; Hesseling-Meinders, Anne; Dijkstra, Bauke W.; Kuipers, Oscar P.; Kok, Jan; Buist, Girbe

    2013-01-01

    Lactococcus lactis expresses the homologous glucosaminidases AcmB, AcmC, AcmA and AcmD. The latter two have three C-terminal LysM repeats for peptidoglycan binding. AcmD has much shorter intervening sequences separating the LysM repeats and a lower iso-electric point (4.3) than AcmA (10.3). Under standard laboratory conditions AcmD was mainly secreted into the culture supernatant. An L. lactis acmAacmD double mutant formed longer chains than the acmA single mutant, indicating that AcmD contributes to cell separation. This phenotype could be complemented by plasmid-encoded expression of AcmD in the double mutant. No clear difference in cellular lysis and protein secretion was observed between both mutants. Nevertheless, overexpression of AcmD resulted in increased autolysis when AcmA was present (as in the wild type strain) or when AcmA was added to the culture medium of an AcmA-minus strain. Possibly, AcmD is mainly active within the cell wall, at places where proper conditions are present for its binding and catalytic activity. Various fusion proteins carrying either the three LysM repeats of AcmA or AcmD were used to study and compare their cell wall binding characteristics. Whereas binding of the LysM domain of AcmA took place at pHs ranging from 4 to 8, LysM domain of AcmD seems to bind strongest at pH 4. PMID:23951292

  13. Acme Foundry, Inc. - Clean Water Act Public Notice

    EPA Pesticide Factsheets

    The EPA is providing notice of a proposed Administrative Penalty Assessment against Acme Foundry, Inc., for alleged violations at its facility located at 1502 South Spruce Street, Coffeyville, Kansas 67337

  14. Prevalence and genetic diversity of arginine catabolic mobile element (ACME) in clinical isolates of coagulase-negative staphylococci: identification of ACME type I variants in Staphylococcus epidermidis.

    PubMed

    Onishi, Mayumi; Urushibara, Noriko; Kawaguchiya, Mitsuyo; Ghosh, Souvik; Shinagawa, Masaaki; Watanabe, Naoki; Kobayashi, Nobumichi

    2013-12-01

    Arginine catabolic mobile element (ACME), a genomic island consisting of the arc and/or opp3 gene clusters found in staphylococcal species, is related to increased bacterial adaptability to hosts. Staphylococcus epidermidis is considered a major ACME reservoir; however, prevalence and genetic diversity of ACME in coagulase-negative staphylococci (CNS) have not yet been well characterized for clinical isolates in Japan. A total of 271 clinical isolates of CNS in a Japanese hospital were investigated for the presence and genotype of ACME and SCCmec. The prevalence of ACME-arcA was significantly higher (p<0.001) in S. epidermidis (45.8%) than in other CNS species (3.7%). ACME in S. epidermidis isolates (n=87) were differentiated into type I (n=33), variant forms of type I (ΔI, n=26) newly identified in this study, type II (n=6), and type ΔII (n=19). ACME-type ΔI, which were further classified into three subtypes, lacked some genetic components between the arc and opp3 clusters in archetypal type I, whereas the arc and opp3 clusters were intact. The arc cluster exhibited high sequence identity (95.8-100%) to that of type I ACME; in contrast, the opp3 cluster was highly diverse, and showed relatively lower identities (94.8-98.7%) to the identical regions in type I ACME. Twenty-one isolates of ΔI ACME-carrying S. epidermidis possessed SCCmec IVa and belonged to ST5 (clonal complex 2). Phylogenetic analysis revealed that isolates harboring ACME ΔI in this study clustered with previously reported S. epidermidis strains with other lineges, suggesting that S. epidermidis originally had some genetic variations in the opp3 cluster. In summary, ACME type ΔI, a truncated variant of ACME-I, was first identified in S. epidermidis, and revealed to be prevalent in ST5 MRSE clinical isolates with SCCmec IVa.

  15. Sealing Force Increasing of ACM Gasket through Electron Beam Radiation

    NASA Astrophysics Data System (ADS)

    dos Santos, D. J.; Batalha, G. F.

    2011-01-01

    Rubber is an engineering material largely used as sealing parts, in form of O-rings, solid gaskets and liquid gaskets, materials applied in liquid state with posterior vulcanization and sealing. Stress relaxation is a rubber characteristic which impacts negatively in such industrial applications (rings and solid gaskets). This work has the purpose to investigate the use of electron beam radiation (EB) as a technology able to decrease the stress relaxation in acrylic rubber (ACM), consequently increasing the sealing capability of this material. ACM samples were irradiated with dose of 100 kGy and 250 kGy, its behavior was comparatively investigated using, dynamic mechanical analysis (DMA) and compression stress relaxation (CSR) experiments. The results obtained by DMA shown an increase of Tg and changes in dynamic mechanical behavior.

  16. 76 FR 64943 - Proposed Cercla Administrative Cost Recovery Settlement; ACM Smelter and Refinery Site, Located...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... AGENCY Proposed Cercla Administrative Cost Recovery Settlement; ACM Smelter and Refinery Site, Located in... administrative settlement for recovery of past and projected future response costs concerning the ACM Smelter and...-5027. Comments should reference the ACM Smelter and Refinery NPL Site, the EPA Docket No....

  17. ACME, a GIS tool for Automated Cirque Metric Extraction

    NASA Astrophysics Data System (ADS)

    Spagnolo, Matteo; Pellitero, Ramon; Barr, Iestyn D.; Ely, Jeremy C.; Pellicer, Xavier M.; Rea, Brice R.

    2017-02-01

    Regional scale studies of glacial cirque metrics provide key insights on the (palaeo) environment related to the formation of these erosional landforms. The growing availability of high resolution terrain models means that more glacial cirques can be identified and mapped in the future. However, the extraction of their metrics still largely relies on time consuming manual techniques or the combination of, more or less obsolete, GIS tools. In this paper, a newly coded toolbox is provided for the automated, and comparatively quick, extraction of 16 key glacial cirque metrics; including length, width, circularity, planar and 3D area, elevation, slope, aspect, plan closure and hypsometry. The set of tools, named ACME (Automated Cirque Metric Extraction), is coded in Python, runs in one of the most commonly used GIS packages (ArcGIS) and has a user friendly interface. A polygon layer of mapped cirques is required for all metrics, while a Digital Terrain Model and a point layer of cirque threshold midpoints are needed to run some of the tools. Results from ACME are comparable to those from other techniques and can be obtained rapidly, allowing large cirque datasets to be analysed and potentially important regional trends highlighted.

  18. Acme jumper pipe system for coke-oven charging

    SciTech Connect

    Medved, P.D.; Thomas, H.

    1996-08-01

    Acme Steel has operated larry cars with an attached jumper pipe since 1977 and had been able to meet the State Implementation Plan (SIP). With the advent of the Clean Air Act (CAA), Acme considered that it could not meet these new standards without modifications to the jumper pipe system. Several drop sleeve modifications, boot seal materials and configurations were tested that resulted in limited success in improving the boot seal life. These modifications showed that the Clean Air Act standards could be met, but it would be cost prohibitive to continue to operate in this manner. The company decided to install an off-car jumper pipe system which uses a traveling U-tube for connection to the assist oven through an additional hole in the roof of each oven. Temperature related failures of drop sleeve seals were eliminated. The off-car jumper pipe is a more efficient gas connection to the assist oven and enables the company to meet the Clean Air Act charging requirements in a cost effective manner.

  19. Fuel gas main replacement at Acme Steel's coke plant

    SciTech Connect

    Trevino, O. . Chicago Coke Plant)

    1994-09-01

    ACME Steel's Chicago coke plant consists of two 4-meter, 50-oven Wilputte underjet coke-oven batteries. These batteries were constructed in 1956--1957. The use of blast furnace gas was discontinued in the late 1960's. In 1977--1978, the oven walls in both batteries were reconstructed. Reconstruction of the underfire system was limited to rebuilding the coke-oven gas reversing cocks and meter in orifices. By the early 1980's, the 24-in. diameter underfire fuel gas mains of both batteries developed leaks at the Dresser expansion joints. These leaks were a result of pipe loss due to corrosion. Leaks also developed along the bottoms and sides of both mains. A method is described that permitted pushing temperatures to be maintained during replacement of underfire fuel gas mains. Each of Acme's two, 50-oven, 4-metric Wilputte coke-oven, gas-fired batteries were heated by converting 10-in. diameter decarbonizing air mains into temporary fuel gas mains. Replacement was made one battery at a time, with the temporary 10-in. mains in service for five to eight weeks.

  20. Towards an Autonomic Cluster Management System (ACMS) with Reflex Autonomicity

    NASA Technical Reports Server (NTRS)

    Truszkowski, Walt; Hinchey, Mike; Sterritt, Roy

    2005-01-01

    Cluster computing, whereby a large number of simple processors or nodes are combined together to apparently function as a single powerful computer, has emerged as a research area in its own right. The approach offers a relatively inexpensive means of providing a fault-tolerant environment and achieving significant computational capabilities for high-performance computing applications. However, the task of manually managing and configuring a cluster quickly becomes daunting as the cluster grows in size. Autonomic computing, with its vision to provide self-management, can potentially solve many of the problems inherent in cluster management. We describe the development of a prototype Autonomic Cluster Management System (ACMS) that exploits autonomic properties in automating cluster management and its evolution to include reflex reactions via pulse monitoring.

  1. Air Traffic Complexity Measurement Environment (ACME): Software User's Guide

    NASA Technical Reports Server (NTRS)

    1996-01-01

    A user's guide for the Air Traffic Complexity Measurement Environment (ACME) software is presented. The ACME consists of two major components, a complexity analysis tool and user interface. The Complexity Analysis Tool (CAT) analyzes complexity off-line, producing data files which may be examined interactively via the Complexity Data Analysis Tool (CDAT). The Complexity Analysis Tool is composed of three independently executing processes that communicate via PVM (Parallel Virtual Machine) and Unix sockets. The Runtime Data Management and Control process (RUNDMC) extracts flight plan and track information from a SAR input file, and sends the information to GARP (Generate Aircraft Routes Process) and CAT (Complexity Analysis Task). GARP in turn generates aircraft trajectories, which are utilized by CAT to calculate sector complexity. CAT writes flight plan, track and complexity data to an output file, which can be examined interactively. The Complexity Data Analysis Tool (CDAT) provides an interactive graphic environment for examining the complexity data produced by the Complexity Analysis Tool (CAT). CDAT can also play back track data extracted from System Analysis Recording (SAR) tapes. The CDAT user interface consists of a primary window, a controls window, and miscellaneous pop-ups. Aircraft track and position data is displayed in the main viewing area of the primary window. The controls window contains miscellaneous control and display items. Complexity data is displayed in pop-up windows. CDAT plays back sector complexity and aircraft track and position data as a function of time. Controls are provided to start and stop playback, adjust the playback rate, and reposition the display to a specified time.

  2. Contribution of the collagen adhesin Acm to pathogenesis of Enterococcus faecium in experimental endocarditis.

    PubMed

    Nallapareddy, Sreedhar R; Singh, Kavindra V; Murray, Barbara E

    2008-09-01

    Enterococcus faecium is a multidrug-resistant opportunist causing difficult-to-treat nosocomial infections, including endocarditis, but there are no reports experimentally demonstrating E. faecium virulence determinants. Our previous studies showed that some clinical E. faecium isolates produce a cell wall-anchored collagen adhesin, Acm, and that an isogenic acm deletion mutant of the endocarditis-derived strain TX0082 lost collagen adherence. In this study, we show with a rat endocarditis model that TX0082 Deltaacm::cat is highly attenuated versus wild-type TX0082, both in established (72 h) vegetations (P < 0.0001) and for valve colonization 1 and 3 hours after infection (P Acm the first factor shown to be important for E. faecium pathogenesis. In contrast, no mortality differences were observed in a mouse peritonitis model. While 5 of 17 endocarditis isolates were Acm nonproducers and failed to adhere to collagen in vitro, all had an intact, highly conserved acm locus. Highly reduced acm mRNA levels (>or=50-fold reduction relative to an Acm producer) were found in three of these five nonadherent isolates, including the sequenced strain TX0016, by quantitative reverse transcription-PCR, indicating that acm transcription is downregulated in vitro in these isolates. However, examination of TX0016 cells obtained directly from infected rat vegetations by flow cytometry showed that Acm was present on 40% of cells grown during infection. Finally, we demonstrated a significant reduction in E. faecium collagen adherence by affinity-purified anti-Acm antibodies from E. faecium endocarditis patient sera, suggesting that Acm may be a potential immunotarget for strategies to control this emerging pathogen.

  3. Validation of the Adolescent Concerns Measure (ACM): evidence from exploratory and confirmatory factor analysis.

    PubMed

    Ang, Rebecca P; Chong, Wan Har; Huan, Vivien S; Yeo, Lay See

    2007-01-01

    This article reports the development and initial validation of scores obtained from the Adolescent Concerns Measure (ACM), a scale which assesses concerns of Asian adolescent students. In Study 1, findings from exploratory factor analysis using 619 adolescents suggested a 24-item scale with four correlated factors--Family Concerns (9 items), Peer Concerns (5 items), Personal Concerns (6 items), and School Concerns (4 items). Initial estimates of convergent validity for ACM scores were also reported. The four-factor structure of ACM scores derived from Study 1 was confirmed via confirmatory factor analysis in Study 2 using a two-fold cross-validation procedure with a separate sample of 811 adolescents. Support was found for both the multidimensional and hierarchical models of adolescent concerns using the ACM. Internal consistency and test-retest reliability estimates were adequate for research purposes. ACM scores show promise as a reliable and potentially valid measure of Asian adolescents' concerns.

  4. On the characteristics-based ACM for incompressible flows

    NASA Astrophysics Data System (ADS)

    Su, Xiaohui; Zhao, Yong; Huang, Xiaoyang

    2007-11-01

    In this paper, the revised characteristics-based (CB) method for incompressible flows recently derived by Neofytou [P. Neofytou, Revision of the characteristic-based scheme for incompressible flows, J. Comput. Phys. 222 (2007) 475-484] has been further investigated. We have derived all the formulas for pressure and velocities from this revised CB method, which is based on the artificial compressibility method (ACM) [A.J. Chorin, A numerical solution for solving incompressible viscous flow problems, J. Comput. Phys. 2 (1967) 12]. Then we analyze the formulations of the original CB method [D. Drikakis, P.A. Govatsos, D.E. Papatonis, A characteristic based method for incompressible flows, Int. J. Numer. Meth. Fluids 19 (1994) 667-685; E. Shapiro, D. Drikakis, Non-conservative and conservative formulations of characteristics numerical reconstructions for incompressible flows, Int. J. Numer. Meth. Eng. 66 (2006) 1466-1482; D. Drikakis, P.K. Smolarkiewicz, On spurious vortical structures, J. Comput. Phys. 172 (2001) 309-325; F. Mallinger, D. Drikakis, Instability in three-dimensional, unsteady stenotic flows, Int. J. Heat Fluid Flow 23 (2002) 657-663; E. Shapiro, D. Drikakis, Artificial compressibility, characteristics-based schemes for variable density, incompressible, multi-species flows. Parts I. Derivation of different formulations and constant density limit, J. Comput. Phys. 210 (2005) 584-607; Y. Zhao, B. Zhang, A high-order characteristics upwind FV method for incompressible flow and heat transfer simulation on unstructured grids, Comput. Meth. Appl. Mech. Eng. 190 (5-7) (2000) 733-756] to investigate their consistency with the governing flow equations after convergence has been achieved. Furthermore we have implemented both formulations in an unstructured-grid finite volume solver [Y. Zhao, B. Zhang, A high-order characteristics upwind FV method for incompressible flow and heat transfer simulation on unstructured grids, Comput. Meth. Appl. Mech. Eng. 190 (5

  5. ARM Airborne Carbon Measurements VI (ACME VI) Science Plan

    SciTech Connect

    Biraud, S

    2015-12-01

    From October 1 through September 30, 2016, the Atmospheric Radiation Measurement (ARM) Aerial Facility will deploy the Cessna 206 aircraft over the Southern Great Plains (SGP) site, collecting observations of trace-gas mixing ratios over the ARM’s SGP facility. The aircraft payload includes two Atmospheric Observing Systems, Inc., analyzers for continuous measurements of CO2 and a 12-flask sampler for analysis of carbon cycle gases (CO2, CO, CH4, N2O, 13CO2, 14CO2, carbonyl sulfide, and trace hydrocarbon species, including ethane). The aircraft payload also includes instrumentation for solar/infrared radiation measurements. This research is supported by the U.S. Department of Energy’s ARM Climate Research Facility and Terrestrial Ecosystem Science Program and builds upon previous ARM Airborne Carbon Measurements (ARM-ACME) missions. The goal of these measurements is to improve understanding of 1) the carbon exchange at the SGP site, 2) how CO2 and associated water and energy fluxes influence radiative forcing, convective processes and CO2 concentrations over the SGP site, and 3) how greenhouse gases are transported on continental scales.

  6. Pomegranate MR images analysis using ACM and FCM algorithms

    NASA Astrophysics Data System (ADS)

    Morad, Ghobad; Shamsi, Mousa; Sedaaghi, M. H.; Alsharif, M. R.

    2011-10-01

    Segmentation of an image plays an important role in image processing applications. In this paper segmentation of pomegranate magnetic resonance (MR) images has been explored. Pomegranate has healthy nutritional and medicinal properties for which the maturity indices and quality of internal tissues play an important role in the sorting process in which the admissible determination of features mentioned above cannot be easily achieved by human operator. Seeds and soft tissues are the main internal components of pomegranate. For research purposes, such as non-destructive investigation, in order to determine the ripening index and the percentage of seeds in growth period, segmentation of the internal structures should be performed as exactly as possible. In this paper, we present an automatic algorithm to segment the internal structure of pomegranate. Since its intensity of stem and calyx is close to the internal tissues, the stem and calyx pixels are usually labeled to the internal tissues by segmentation algorithm. To solve this problem, first, the fruit shape is extracted from its background using active contour model (ACM). Then stem and calyx are removed using morphological filters. Finally the image is segmented by fuzzy c-means (FCM). The experimental results represent an accuracy of 95.91% in the presence of stem and calyx, while the accuracy of segmentation increases to 97.53% when stem and calyx are first removed by morphological filters.

  7. In-situ Data Analysis Framework for ACME Land Simulations

    NASA Astrophysics Data System (ADS)

    Wang, D.; Yao, C.; Jia, Y.; Steed, C.; Atchley, S.

    2015-12-01

    The realistic representation of key biogeophysical and biogeochemical functions is the fundamental of process-based ecosystem models. Investigating the behavior of those ecosystem functions within real-time model simulation can be a very challenging due to the complex of both model and software structure of an environmental model, such as the Accelerated Climate Model for Energy (ACME) Land Model (ALM). In this research, author will describe the urgent needs and challenges for in-situ data analysis for ALM simulations, and layouts our methods/strategies to meet these challenges. Specifically, an in-situ data analysis framework is designed to allow users interactively observe the biogeophyical and biogeochemical process during ALM simulation. There are two key components in this framework, automatically instrumented ecosystem simulation, in-situ data communication and large-scale data exploratory toolkit. This effort is developed by leveraging several active projects, including scientific unit testing platform, common communication interface and extreme-scale data exploratory toolkit. Authors believe that, based on advanced computing technologies, such as compiler-based software system analysis, automatic code instrumentation, and in-memory data transport, this software system provides not only much needed capability for real-time observation and in-situ data analytics for environmental model simulation, but also the potentials for in-situ model behavior adjustment via simulation steering.

  8. Comparative study of numerical schemes of TVD3, UNO3-ACM and optimized compact scheme

    NASA Technical Reports Server (NTRS)

    Lee, Duck-Joo; Hwang, Chang-Jeon; Ko, Duck-Kon; Kim, Jae-Wook

    1995-01-01

    Three different schemes are employed to solve the benchmark problem. The first one is a conventional TVD-MUSCL (Monotone Upwind Schemes for Conservation Laws) scheme. The second scheme is a UNO3-ACM (Uniformly Non-Oscillatory Artificial Compression Method) scheme. The third scheme is an optimized compact finite difference scheme modified by us: the 4th order Runge Kutta time stepping, the 4th order pentadiagonal compact spatial discretization with the maximum resolution characteristics. The problems of category 1 are solved by using the second (UNO3-ACM) and third (Optimized Compact) schemes. The problems of category 2 are solved by using the first (TVD3) and second (UNO3-ACM) schemes. The problem of category 5 is solved by using the first (TVD3) scheme. It can be concluded from the present calculations that the Optimized Compact scheme and the UN03-ACM show good resolutions for category 1 and category 2 respectively.

  9. Comparative study of numerical schemes of TVD3, UNO3-ACM and optimized compact scheme

    NASA Technical Reports Server (NTRS)

    Lee, Duck-Joo; Hwang, Chang-Jeon; Ko, Duck-Kon; Kim, Jae-Wook

    1995-01-01

    Three different schemes are employed to solve the benchmark problem. The first one is a conventional TVD-MUSCL (Monotone Upwind Schemes for Conservation Laws) scheme. The second scheme is a UNO3-ACM (Uniformly Non-Oscillatory Artificial Compression Method) scheme. The third scheme is an optimized compact finite difference scheme modified by us: the 4th order Runge Kutta time stepping, the 4th order pentadiagonal compact spatial discretization with the maximum resolution characteristics. The problems of category 1 are solved by using the second (UNO3-ACM) and third (Optimized Compact) schemes. The problems of category 2 are solved by using the first (TVD3) and second (UNO3-ACM) schemes. The problem of category 5 is solved by using the first (TVD3) scheme. It can be concluded from the present calculations that the Optimized Compact scheme and the UN03-ACM show good resolutions for category 1 and category 2 respectively.

  10. Inhibition of Enterococcus faecium adherence to collagen by antibodies against high-affinity binding subdomains of Acm.

    PubMed

    Nallapareddy, Sreedhar R; Sillanpää, Jouko; Ganesh, Vannakambadi K; Höök, Magnus; Murray, Barbara E

    2007-06-01

    Strains of Enterococcus faecium express a cell wall-anchored protein, Acm, which mediates adherence to collagen. Here, we (i) identify the minimal and high-affinity binding subsegments of Acm and (ii) show that anti-Acm immunoglobulin Gs (IgGs) purified against these subsegments reduced E. faecium TX2535 strain collagen adherence up to 73 and 50%, respectively, significantly more than the total IgGs against the full-length Acm A domain (28%) (P < 0.0001). Blocking Acm adherence with functional subsegment-specific antibodies raises the possibility of their use as therapeutic or prophylactic agents.

  11. The acellular matrix (ACM) for bladder tissue engineering: A quantitative magnetic resonance imaging study.

    PubMed

    Cheng, Hai-Ling Margaret; Loai, Yasir; Beaumont, Marine; Farhat, Walid A

    2010-08-01

    Bladder acellular matrices (ACMs) derived from natural tissue are gaining increasing attention for their role in tissue engineering and regeneration. Unlike conventional scaffolds based on biodegradable polymers or gels, ACMs possess native biomechanical and many acquired biologic properties. Efforts to optimize ACM-based scaffolds are ongoing and would be greatly assisted by a noninvasive means to characterize scaffold properties and monitor interaction with cells. MRI is well suited to this role, but research with MRI for scaffold characterization has been limited. This study presents initial results from quantitative MRI measurements for bladder ACM characterization and investigates the effects of incorporating hyaluronic acid, a natural biomaterial useful in tissue-engineering and regeneration. Measured MR relaxation times (T(1), T(2)) and diffusion coefficient were consistent with increased water uptake and glycosaminoglycan content observed on biochemistry in hyaluronic acid ACMs. Multicomponent MRI provided greater specificity, with diffusion data showing an acellular environment and T(2) components distinguishing the separate effects of increased glycosaminoglycans and hydration. These results suggest that quantitative MRI may provide useful information on matrix composition and structure, which is valuable in guiding further development using bladder ACMs for organ regeneration and in strategies involving the use of hyaluronic acid.

  12. CNTF-ACM promotes mitochondrial respiration and oxidative stress in cortical neurons through upregulating L-type calcium channel activity.

    PubMed

    Sun, Meiqun; Liu, Hongli; Xu, Huanbai; Wang, Hongtao; Wang, Xiaojing

    2016-09-01

    A specialized culture medium termed ciliary neurotrophic factor-treated astrocyte-conditioned medium (CNTF-ACM) allows investigators to assess the peripheral effects of CNTF-induced activated astrocytes upon cultured neurons. CNTF-ACM has been shown to upregulate neuronal L-type calcium channel current activity, which has been previously linked to changes in mitochondrial respiration and oxidative stress. Therefore, the aim of this study was to evaluate CNTF-ACM's effects upon mitochondrial respiration and oxidative stress in rat cortical neurons. Cortical neurons, CNTF-ACM, and untreated control astrocyte-conditioned medium (UC-ACM) were prepared from neonatal Sprague-Dawley rat cortical tissue. Neurons were cultured in either CNTF-ACM or UC-ACM for a 48-h period. Changes in the following parameters before and after treatment with the L-type calcium channel blocker isradipine were assessed: (i) intracellular calcium levels, (ii) mitochondrial membrane potential (ΔΨm), (iii) oxygen consumption rate (OCR) and adenosine triphosphate (ATP) formation, (iv) intracellular nitric oxide (NO) levels, (v) mitochondrial reactive oxygen species (ROS) production, and (vi) susceptibility to the mitochondrial complex I toxin rotenone. CNTF-ACM neurons displayed the following significant changes relative to UC-ACM neurons: (i) increased intracellular calcium levels (p < 0.05), (ii) elevation in ΔΨm (p < 0.05), (iii) increased OCR and ATP formation (p < 0.05), (iv) increased intracellular NO levels (p < 0.05), (v) increased mitochondrial ROS production (p < 0.05), and (vi) increased susceptibility to rotenone (p < 0.05). Treatment with isradipine was able to partially rescue these negative effects of CNTF-ACM (p < 0.05). CNTF-ACM promotes mitochondrial respiration and oxidative stress in cortical neurons through elevating L-type calcium channel activity.

  13. An audience-channel-message-evaluation (ACME) framework for health communication campaigns.

    PubMed

    Noar, Seth M

    2012-07-01

    Recent reviews of the literature have indicated that a number of health communication campaigns continue to fail to adhere to principles of effective campaign design. The lack of an integrated, organizing framework for the design, implementation, and evaluation of health communication campaigns may contribute to this state of affairs. The current article introduces an audience-channel-message-evaluation (ACME) framework that organizes the major principles of health campaign design, implementation, and evaluation. ACME also explicates the relationships and linkages between the varying principles. Insights from ACME include the following: The choice of audience segment(s) to focus on in a campaign affects all other campaign design choices, including message strategy and channel/component options. Although channel selection influences options for message design, choice of message design also influences channel options. Evaluation should not be thought of as a separate activity, but rather should be infused and integrated throughout the campaign design and implementation process, including formative, process, and outcome evaluation activities. Overall, health communication campaigns that adhere to this integrated set of principles of effective campaign design will have a greater chance of success than those using principles idiosyncratically. These design, implementation, and evaluation principles are embodied in the ACME framework.

  14. Validation of the Adolescent Concerns Measure (ACM): Evidence from Exploratory and Confirmatory Factor Analysis

    ERIC Educational Resources Information Center

    Ang, Rebecca P.; Chong, Wan Har; Huan, Vivien S.; Yeo, Lay See

    2007-01-01

    This article reports the development and initial validation of scores obtained from the Adolescent Concerns Measure (ACM), a scale which assesses concerns of Asian adolescent students. In Study 1, findings from exploratory factor analysis using 619 adolescents suggested a 24-item scale with four correlated factors--Family Concerns (9 items), Peer…

  15. SUPERFUND TREATABILITY CLEARINGHOUSE: FINAL REPORT, PHASE I - IMMEDIATE ASSESSMENT, ACME SOLVENTS SITE

    EPA Science Inventory

    This is a site assessment and feasibility study of incineration alternatives at the ACME Solvents Site at Rockford, Illinois. The document contains laboratory results that are reported to simulate incineration conditions but no details on test methods were provided. The d...

  16. SUPERFUND TREATABILITY CLEARINGHOUSE: FINAL REPORT, PHASE I - IMMEDIATE ASSESSMENT, ACME SOLVENTS SITE

    EPA Science Inventory

    This is a site assessment and feasibility study of incineration alternatives at the ACME Solvents Site at Rockford, Illinois. The document contains laboratory results that are reported to simulate incineration conditions but no details on test methods were provided. The d...

  17. On-resin conversion of Cys(Acm)-containing peptides to their corresponding Cys(Scm) congeners.

    PubMed

    Mullen, Daniel G; Weigel, Benjamin; Barany, George; Distefano, Mark D

    2010-05-01

    The Acm protecting group for the thiol functionality of cysteine is removed under conditions (Hg(2+)) that are orthogonal to the acidic milieu used for global deprotection in Fmoc-based solid-phase peptide synthesis. This use of a toxic heavy metal for deprotection has limited the usefulness of Acm in peptide synthesis. The Acm group may be converted to the Scm derivative that can then be used as a reactive intermediate for unsymmetrical disulfide formation. It may also be removed by mild reductive conditions to generate unprotected cysteine. Conversion of Cys(Acm)-containing peptides to their corresponding Cys(Scm) derivatives in solution is often problematic because the sulfenyl chloride reagent used for this conversion may react with the sensitive amino acids tyrosine and tryptophan. In this protocol, we report a method for on-resin Acm to Scm conversion that allows the preparation of Cys(Scm)-containing peptides under conditions that do not modify other amino acids.

  18. Categorization of Computing Education Resources into the ACM Computing Classification System

    SciTech Connect

    Chen, Yinlin; Bogen, Paul Logasa; Fox, Dr. Edward A.; Hsieh, Dr. Haowei; Cassel, Dr. Lillian N.

    2012-01-01

    The Ensemble Portal harvests resources from multiple heterogonous federated collections. Managing these dynamically increasing collections requires an automatic mechanism to categorize records in to corresponding topics. We propose an approach to use existing ACM DL metadata to build classifiers for harvested resources in the Ensemble project. We also present our experience on utilizing the Amazon Mechanical Turk platform to build ground truth training data sets from Ensemble collections.

  19. Clouds and Precipitation Simulated by the US DOE Accelerated Climate Modeling for Energy (ACME)

    NASA Astrophysics Data System (ADS)

    Xie, S.; Lin, W.; Yoon, J. H.; Ma, P. L.; Rasch, P. J.; Ghan, S.; Zhang, K.; Zhang, Y.; Zhang, C.; Bogenschutz, P.; Gettelman, A.; Larson, V. E.; Neale, R. B.; Park, S.; Zhang, G. J.

    2015-12-01

    A new US Department of Energy (DOE) climate modeling effort is to develop an Accelerated Climate Model for Energy (ACME) to accelerate the development and application of fully coupled, state-of-the-art Earth system models for scientific and energy application. ACME is a high-resolution climate model with a 0.25 degree in horizontal and more than 60 levels in the vertical. It starts from the Community Earth System Model (CESM) with notable changes to its physical parameterizations and other components. This presentation provides an overview on the ACME model's capability in simulating clouds and precipitation and its sensitivity to convection schemes. Results with using several state-of-the-art cumulus convection schemes, including those unified parameterizations that are being developed in the climate community, will be presented. These convection schemes are evaluated in a multi-scale framework including both short-range hindcasts and free-running climate simulations with both satellite data and ground-based measurements. Running climate model in short-range hindcasts has been proven to be an efficient way to understand model deficiencies. The analysis is focused on those systematic errors in clouds and precipitation simulations that are shared in many climate models. The goal is to understand what model deficiencies might be primarily responsible for these systematic errors.

  20. Effects of activated ACM on expression of signal transducers in cerebral cortical neurons of rats.

    PubMed

    Wang, Xiaojing; Li, Zhengli; Zhu, Changgeng; Li, Zhongyu

    2007-06-01

    To explore the roles of astrocytes in the epileptogenesis, astrocytes and neurons were isolated, purified and cultured in vitro from cerebral cortex of rats. The astrocytes were activated by ciliary neurotrophic factor (CNTF) and astrocytic conditioned medium (ACM) was collected to treat neurons for 4, 8 and 12 h. By using Western blot, the expression of calmodulin dependent protein kinase II (CaMK II), inducible nitric oxide synthase (iNOS) and adenylate cyclase (AC) was detected in neurons. The results showed that the expression of CaMK II, iNOS and AC was increased significantly in the neurons treated with ACM from 4 h to 12 h (P<0.05), and that of iNOS and AC peaked at 8 h and 12 h respectively. It was suggested that there might be some epileptogenic factors in the ACM and such signal pathways as NOS-NO-cGMP, Ca2+/CaM-CaMK II and AC-cAMP-PKA might take part in the signal transduction of epileptogenesis.

  1. Model Diagnostics for the Department of Energy's Accelerated Climate Modeling for Energy (ACME) Project

    NASA Astrophysics Data System (ADS)

    Smith, B.

    2015-12-01

    In 2014, eight Department of Energy (DOE) national laboratories, four academic institutions, one company, and the National Centre for Atmospheric Research combined forces in a project called Accelerated Climate Modeling for Energy (ACME) with the goal to speed Earth system model development for climate and energy. Over the planned 10-year span, the project will conduct simulations and modeling on DOE's most powerful high-performance computing systems at Oak Ridge, Argonne, and Lawrence Berkeley Leadership Compute Facilities. A key component of the ACME project is the development of an interactive test bed for the advanced Earth system model. Its execution infrastructure will accelerate model development and testing cycles. The ACME Workflow Group is leading the efforts to automate labor-intensive tasks, provide intelligent support for complex tasks and reduce duplication of effort through collaboration support. As part of this new workflow environment, we have created a diagnostic, metric, and intercomparison Python framework, called UVCMetrics, to aid in the testing-to-production execution of the ACME model. The framework exploits similarities among different diagnostics to compactly support diagnosis of new models. It presently focuses on atmosphere and land but is designed to support ocean and sea ice model components as well. This framework is built on top of the existing open-source software framework known as the Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT). Because of its flexible framework design, scientists and modelers now can generate thousands of possible diagnostic outputs. These diagnostics can compare model runs, compare model vs. observation, or simply verify a model is physically realistic. Additional diagnostics are easily integrated into the framework, and our users have already added several. Diagnostics can be generated, viewed, and manipulated from the UV-CDAT graphical user interface, Python command line scripts and programs

  2. Kleene Algebra and Bytecode Verification

    DTIC Science & Technology

    2016-04-27

    Languages, ACM SIGPLAN/SIGACT, 1998, pp. 149–160. [2] Coglio, A., Simple verification technique for complex Java bytecode subroutines, Concurrency and...of Programming Languages (POPL’73), ACM , 1973, pp. 194–206. [6] Kot, L. and D. Kozen, Second-order abstract interpretation via Kleene algebra

  3. Algorithm-Independent Framework for Verifying Integer Constraints

    DTIC Science & Technology

    2007-11-02

    TAL [7], Crary and Weirich [5]’s resource bound certifitation, Wang and Appel [16]’s safe garbage collection and an attempt at making the whole PCC...S. Weirich . Resource bound certification. In Proc. 27th Annual ACM SIGPLAN- SIGACT Symp. on Principles of Programming Languages. ACM Press, 2000. 30

  4. Irrigation impacts on the water cycle and regional climate simulated by the ACME Model

    NASA Astrophysics Data System (ADS)

    Leng, G.; Leung, L. R.; Huang, M.

    2016-12-01

    Irrigation constitutes 70% and 90% of total human freshwater withdraws and consumptions, respectively. In this study, we use the newly developed Accelerated Climate Modeling for Energy (ACME) Earth system model to address the overarching science question as to how irrigation water use interact with terrestrial water resources and feedback to the climate. The location, timing, amount, and sources of irrigation water and irrigate methods are all key processes in modeling irrigation water use and represented in the ACME land model (ALM). Specifically, irrigation starts when soil water content induces soil moisture stress for crops in the prescribed irrigated areas. The soil water deficit is withdrawn from surface water and groundwater. The parameters determining the irrigation amount and surface water/groundwater pumping rate were calibrated to match observations. Irrigation techniques such as sprinkler, flood and drip irrigation as well as irrigation water use efficiency (i.e., the losses during water transport and irrigation application) were also incorporated. The modeling framework was validated against global observations. Generally, including irrigation water use improves the correlation of simulated water components with observations. Several numerical experiments were conducted to examine the irrigation effects on global land surface water and energy flux and its feedback to climate by the coupled land-atmosphere components of ACME. Initial results show that irrigation has greatly interrupted the regional water balance, with alteration of seasonal variability of TWS, increase of evapotranspiration and decrease of streamflow. This alteration is particularly large over heavily irrigated basins such as the Columbia, the Mississippi, the Indus and the Ganges. The shift of water vapor balance and changes in regional climate induced by irrigation will also be briefly discussed.

  5. Improving Throughput of the ACME Climate Model by Parallel Splitting Atmospheric Physics and Dynamics

    NASA Astrophysics Data System (ADS)

    Caldwell, P.; Taylor, M.

    2015-12-01

    If fluid dynamics and atmospheric physics parameterizations were computed in parallel, they could be calculated simultaneously on separate cores of a supercomputer. This would greatly increase model throughput for high-resolution simulations. Additionally, because atmospheric physics is embarrassingly parallel, more sophisticated physics parameterizations could be used without slowing simulations down by simply increasing the number of cores used. The downside to this approach is that it increases time-truncation error. In this presentation, we demonstrate that parallel splitting the ACME model and using a smaller timestep for physics results in faster, more accurate solutions.

  6. Information Criterion Comparison of Two Deep Convection Ensembles in the ACME Climate Model

    NASA Astrophysics Data System (ADS)

    Lucas, D. D.; Anderson, G. J.; Bulaevskaya, V.; Chowdhary, K.; Debusschere, B.; Ghan, S. J.

    2016-12-01

    Statistical model selection methods have been developed and applied to compare the performance of two deep convection parameterizations in the U.S. Dept. of Energy's ACME climate model. The comparison is based on information criterion scores that summarize the goodness-of-fit to observations of tropical precipitation and penalize against overfitting. The scores are derived using an ensemble of 400 Latin hypercube simulations of the global ACME model (1 degree, 30 levels) that perturb parameters in the Zhang-Mcfarlane and Chikira deep convection schemes. The ensemble is used to train statistical models, identify influential model parameters, determine maximum likelihood estimates, and compute information criterion scores. The scores can be used to provide guidance on the selection of a deep convection parameterization for a climate model. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344, and is supported by the DOE Office of Science through the Scientific Discovery Through Advanced Computing (SciDAC).

  7. Superfund Record of Decision (EPA Region 5): Acme Solvents, Morristown, Illinois, September 1985. Final report

    SciTech Connect

    Not Available

    1985-09-27

    The Acme Solvents Reclaiming, Inc. facility is located approximately five miles south of Rockford, Illinois. From 1960 until 1973, the facility served as a disposal site for paints, oils and still bottoms from the solvent reclamation plant located in Rockford. In addition, empty drums were stored onsite. Wastes were dumped into depressions created from either previous quarrying activities or by scraping overburden from the near surface bedrock to form berms. In September 1972, the Illinois Pollution Control Board (IPCB) ordered Acme to remove all drums and wastes from the facility and to backfill the lagoons. Follow-up inspections revealed that wastes and crushed drums were being left onsite and merely covered with soil. Sampling of the site revealed high concentrations of chlorinated organics in the drinking water. The major source of hazardous substances at the facility are the waste disposal mounds. These mounds contain volatile and semi-volatile organic compounds and concentrations of PCBs up to several hundred mg/kg. The selected remedial action is included.

  8. TWO NOVEL ACM (ACTIVE CONTOUR MODEL) METHODS FOR INTRAVASCULAR ULTRASOUND IMAGE SEGMENTATION

    SciTech Connect

    Chen, Chi Hau; Potdat, Labhesh; Chittineni, Rakesh

    2010-02-22

    One of the attractive image segmentation methods is the Active Contour Model (ACM) which has been widely used in medical imaging as it always produces sub-regions with continuous boundaries. Intravascular ultrasound (IVUS) is a catheter based medical imaging technique which is used for quantitative assessment of atherosclerotic disease. Two methods of ACM realizations are presented in this paper. The gradient descent flow based on minimizing energy functional can be used for segmentation of IVUS images. However this local operation alone may not be adequate to work with the complex IVUS images. The first method presented consists of basically combining the local geodesic active contours and global region-based active contours. The advantage of combining the local and global operations is to allow curves deforming under the energy to find only significant local minima and delineate object borders despite noise, poor edge information and heterogeneous intensity profiles. Results for this algorithm are compared to standard techniques to demonstrate the method's robustness and accuracy. In the second method, the energy function is appropriately modified and minimized using a Hopfield neural network. Proper modifications in the definition of the bias of the neurons have been introduced to incorporate image characteristics. The method overcomes distortions in the expected image pattern, such as due to the presence of calcium, and employs a specialized structure of the neural network and boundary correction schemes which are based on a priori knowledge about the vessel geometry. The presented method is very fast and has been evaluated using sequences of IVUS frames.

  9. Two Novel ACM (active Contour Model) Methods for Intravascular Ultrasound Image Segmentation

    NASA Astrophysics Data System (ADS)

    Chen, Chi Hau; Potdat, Labhesh; Chittineni, Rakesh

    2010-02-01

    One of the attractive image segmentation methods is the Active Contour Model (ACM) which has been widely used in medical imaging as it always produces sub-regions with continuous boundaries. Intravascular ultrasound (IVUS) is a catheter based medical imaging technique which is used for quantitative assessment of atherosclerotic disease. Two methods of ACM realizations are presented in this paper. The gradient descent flow based on minimizing energy functional can be used for segmentation of IVUS images. However this local operation alone may not be adequate to work with the complex IVUS images. The first method presented consists of basically combining the local geodesic active contours and global region-based active contours. The advantage of combining the local and global operations is to allow curves deforming under the energy to find only significant local minima and delineate object borders despite noise, poor edge information and heterogeneous intensity profiles. Results for this algorithm are compared to standard techniques to demonstrate the method's robustness and accuracy. In the second method, the energy function is appropriately modified and minimized using a Hopfield neural network. Proper modifications in the definition of the bias of the neurons have been introduced to incorporate image characteristics. The method overcomes distortions in the expected image pattern, such as due to the presence of calcium, and employs a specialized structure of the neural network and boundary correction schemes which are based on a priori knowledge about the vessel geometry. The presented method is very fast and has been evaluated using sequences of IVUS frames.

  10. Clinical isolates of Enterococcus faecium exhibit strain-specific collagen binding mediated by Acm, a new member of the MSCRAMM family.

    PubMed

    Nallapareddy, Sreedhar R; Weinstock, George M; Murray, Barbara E

    2003-03-01

    A collagen-binding adhesin of Enterococcus faecium, Acm, was identified. Acm shows 62% similarity to the Staphylococcus aureus collagen adhesin Cna over the entire protein and is more similar to Cna (60% and 75% similarity with Cna A and B domains respectively) than to the Enterococcus faecalis collagen-binding adhesin, Ace, which shares homology with Acm only in the A domain. Despite the detection of acm in 32 out of 32 E. faecium isolates, only 11 of these (all clinical isolates, including four vancomycin-resistant endocarditis isolates and seven other isolates) exhibited binding to collagen type I (CI). Although acm from three CI-binding vancomycin-resistant E. faecium clinical isolates showed 100% identity, analysis of acm genes and their promoter regions from six non-CI-binding strains identified deletions or mutations that introduced stop codons and/or IS elements within the gene or the promoter region in five out of six strains, suggesting that the presence of an intact functional acm gene is necessary for binding of E. faecium strains to CI. Recombinant Acm A domain showed specific and concentration-dependent binding to collagen, and this protein competed with E. faecium binding to immobilized CI. Consistent with the adherence phenotype and sequence data, probing with Acm-specific IgGs purified from anti-recombinant Acm A polyclonal rabbit serum confirmed the surface expression of Acm in three out of three collagen-binding clinical isolates of E. faecium tested, but in none of the strains with a non-functional pseudo acm gene. Introduction of a functional acm gene into two non-CI-binding natural acm mutant strains conferred a CI-binding phenotype, further confirming that native Acm is sufficient for the binding of E. faecium to CI. These results demonstrate that acm, which encodes a potential virulence factor, is functional only in certain infection-derived clinical isolates of E. faecium, and suggest that Acm is the primary adhesin responsible for the

  11. AcmB Is an S-Layer-Associated β-N-Acetylglucosaminidase and Functional Autolysin in Lactobacillus acidophilus NCFM

    PubMed Central

    Johnson, Brant R.

    2016-01-01

    ABSTRACT Autolysins, also known as peptidoglycan hydrolases, are enzymes that hydrolyze specific bonds within bacterial cell wall peptidoglycan during cell division and daughter cell separation. Within the genome of Lactobacillus acidophilus NCFM, there are 11 genes encoding proteins with peptidoglycan hydrolase catalytic domains, 9 of which are predicted to be functional. Notably, 5 of the 9 putative autolysins in L. acidophilus NCFM are S-layer-associated proteins (SLAPs) noncovalently colocalized along with the surface (S)-layer at the cell surface. One of these SLAPs, AcmB, a β-N-acetylglucosaminidase encoded by the gene lba0176 (acmB), was selected for functional analysis. In silico analysis revealed that acmB orthologs are found exclusively in S-layer- forming species of Lactobacillus. Chromosomal deletion of acmB resulted in aberrant cell division, autolysis, and autoaggregation. Complementation of acmB in the ΔacmB mutant restored the wild-type phenotype, confirming the role of this SLAP in cell division. The absence of AcmB within the exoproteome had a pleiotropic effect on the extracellular proteins covalently and noncovalently bound to the peptidoglycan, which likely led to the observed decrease in the binding capacity of the ΔacmB strain for mucin and extracellular matrices fibronectin, laminin, and collagen in vitro. These data suggest a functional association between the S-layer and the multiple autolysins noncovalently colocalized at the cell surface of L. acidophilus NCFM and other S-layer-producing Lactobacillus species. IMPORTANCE Lactobacillus acidophilus is one of the most widely used probiotic microbes incorporated in many dairy foods and dietary supplements. This organism produces a surface (S)-layer, which is a self-assembling crystalline array found as the outermost layer of the cell wall. The S-layer, along with colocalized associated proteins, is an important mediator of probiotic activity through intestinal adhesion and modulation of

  12. Can Pearlite form Outside of the Hultgren Extrapolation of the Ae3 and Acm Phase Boundaries?

    NASA Astrophysics Data System (ADS)

    Aranda, M. M.; Rementeria, R.; Capdevila, C.; Hackenberg, R. E.

    2016-02-01

    It is usually assumed that ferrous pearlite can form only when the average austenite carbon concentration C 0 lies between the extrapolated Ae3 ( γ/ α) and Acm ( γ/ θ) phase boundaries (the "Hultgren extrapolation"). This "mutual supersaturation" criterion for cooperative lamellar nucleation and growth is critically examined from a historical perspective and in light of recent experiments on coarse-grained hypoeutectoid steels which show pearlite formation outside the Hultgren extrapolation. This criterion, at least as interpreted in terms of the average austenite composition, is shown to be unnecessarily restrictive. The carbon fluxes evaluated from Brandt's solution are sufficient to allow pearlite growth both inside and outside the Hultgren Extrapolation. As for the feasibility of the nucleation events leading to pearlite, the only criterion is that there are some local regions of austenite inside the Hultgren Extrapolation, even if the average austenite composition is outside.

  13. Autonomic Cluster Management System (ACMS): A Demonstration of Autonomic Principles at Work

    NASA Technical Reports Server (NTRS)

    Baldassari, James D.; Kopec, Christopher L.; Leshay, Eric S.; Truszkowski, Walt; Finkel, David

    2005-01-01

    Cluster computing, whereby a large number of simple processors or nodes are combined together to apparently function as a single powerful computer, has emerged as a research area in its own right. The approach offers a relatively inexpensive means of achieving significant computational capabilities for high-performance computing applications, while simultaneously affording the ability to. increase that capability simply by adding more (inexpensive) processors. However, the task of manually managing and con.guring a cluster quickly becomes impossible as the cluster grows in size. Autonomic computing is a relatively new approach to managing complex systems that can potentially solve many of the problems inherent in cluster management. We describe the development of a prototype Automatic Cluster Management System (ACMS) that exploits autonomic properties in automating cluster management.

  14. ACME: automated cell morphology extractor for comprehensive reconstruction of cell membranes.

    PubMed

    Mosaliganti, Kishore R; Noche, Ramil R; Xiong, Fengzhu; Swinburne, Ian A; Megason, Sean G

    2012-01-01

    The quantification of cell shape, cell migration, and cell rearrangements is important for addressing classical questions in developmental biology such as patterning and tissue morphogenesis. Time-lapse microscopic imaging of transgenic embryos expressing fluorescent reporters is the method of choice for tracking morphogenetic changes and establishing cell lineages and fate maps in vivo. However, the manual steps involved in curating thousands of putative cell segmentations have been a major bottleneck in the application of these technologies especially for cell membranes. Segmentation of cell membranes while more difficult than nuclear segmentation is necessary for quantifying the relations between changes in cell morphology and morphogenesis. We present a novel and fully automated method to first reconstruct membrane signals and then segment out cells from 3D membrane images even in dense tissues. The approach has three stages: 1) detection of local membrane planes, 2) voting to fill structural gaps, and 3) region segmentation. We demonstrate the superior performance of the algorithms quantitatively on time-lapse confocal and two-photon images of zebrafish neuroectoderm and paraxial mesoderm by comparing its results with those derived from human inspection. We also compared with synthetic microscopic images generated by simulating the process of imaging with fluorescent reporters under varying conditions of noise. Both the over-segmentation and under-segmentation percentages of our method are around 5%. The volume overlap of individual cells, compared to expert manual segmentation, is consistently over 84%. By using our software (ACME) to study somite formation, we were able to segment touching cells with high accuracy and reliably quantify changes in morphogenetic parameters such as cell shape and size, and the arrangement of epithelial and mesenchymal cells. Our software has been developed and tested on Windows, Mac, and Linux platforms and is available

  15. Sparse Polynomial Chaos Surrogate for ACME Land Model via Iterative Bayesian Compressive Sensing

    NASA Astrophysics Data System (ADS)

    Sargsyan, K.; Ricciuto, D. M.; Safta, C.; Debusschere, B.; Najm, H. N.; Thornton, P. E.

    2015-12-01

    For computationally expensive climate models, Monte-Carlo approaches of exploring the input parameter space are often prohibitive due to slow convergence with respect to ensemble size. To alleviate this, we build inexpensive surrogates using uncertainty quantification (UQ) methods employing Polynomial Chaos (PC) expansions that approximate the input-output relationships using as few model evaluations as possible. However, when many uncertain input parameters are present, such UQ studies suffer from the curse of dimensionality. In particular, for 50-100 input parameters non-adaptive PC representations have infeasible numbers of basis terms. To this end, we develop and employ Weighted Iterative Bayesian Compressive Sensing to learn the most important input parameter relationships for efficient, sparse PC surrogate construction with posterior uncertainty quantified due to insufficient data. Besides drastic dimensionality reduction, the uncertain surrogate can efficiently replace the model in computationally intensive studies such as forward uncertainty propagation and variance-based sensitivity analysis, as well as design optimization and parameter estimation using observational data. We applied the surrogate construction and variance-based uncertainty decomposition to Accelerated Climate Model for Energy (ACME) Land Model for several output QoIs at nearly 100 FLUXNET sites covering multiple plant functional types and climates, varying 65 input parameters over broad ranges of possible values. This work is supported by the U.S. Department of Energy, Office of Science, Biological and Environmental Research, Accelerated Climate Modeling for Energy (ACME) project. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  16. AcmA of Lactococcus lactis is an N-acetylglucosaminidase with an optimal number of LysM domains for proper functioning.

    PubMed

    Steen, Anton; Buist, Girbe; Horsburgh, Gavin J; Venema, Gerard; Kuipers, Oscar P; Foster, Simon J; Kok, Jan

    2005-06-01

    AcmA, the major autolysin of Lactococcus lactis MG1363 is a modular protein consisting of an N-terminal active site domain and a C-terminal peptidoglycan-binding domain. The active site domain is homologous to that of muramidase-2 of Enterococcus hirae, however, RP-HPLC analysis of muropeptides released from Bacillus subtilis peptidoglycan, after digestion with AcmA, shows that AcmA is an N-acetylglucosaminidase. In the C-terminus of AcmA three highly similar repeated regions of 45 amino acid residues are present, which are separated by short nonhomologous sequences. The repeats of AcmA, which belong to the lysine motif (LysM) domain family, were consecutively deleted, removed, or, alternatively, one additional repeat was added, without destroying the cell wall-hydrolyzing activity of the enzyme in vitro, although AcmA activity was reduced in all cases. In vivo, proteins containing no or only one repeat did not give rise to autolysis of lactococcal cells, whereas separation of the producer cells from the chains was incomplete. Exogenously added AcmA deletion derivatives carrying two repeats or four repeats bound to lactococcal cells, whereas the derivative with no or one repeat did not. In conclusion, these results show that AcmA needs three LysM domains for optimal peptidoglycan binding and biological functioning.

  17. Preliminary survey report: control technology for the ceramic industry at Acme Brick Company, Malvern, Arkansas

    SciTech Connect

    Godbey, F.W.

    1983-06-01

    Health-hazard control methods, work processes, and existing control technologies used in the manufacture of brick were surveyed at Acme Brick Company, Malvern, Arkansas in June, 1983. The company employed about 32 workers to produce structural brick from alluvial clay, free clay, shale, and aggregate. A potential hazard existed from silica exposure since the clays contained about 20% quartz. Raw materials were transported in a cab-enclosed front-end loader to feeders that delivered the materials to a crusher. Blended coarsely crushed material was moved by conveyor to a hammer mill for fine crushing. Production-size product was transported by overhead conveyor to storage silos in the production building. The entire material particle-size reduction process was completely automated. The clay-preparation building and raw-material storage area were isolated from the production building, and only two workers performed the crushing and grinding operations. Material transfer points had removable covers, and a water-mist spray was used on one conveyor of each line. The operation was monitored from a totally enclosed air-conditioned control room. Head and eye protection were required. The author does not recommend an in-depth study of control technologies of the company.

  18. Use of composable solvers to represent multiphysics hydrologic and thermal processes in the ACME Land Model

    NASA Astrophysics Data System (ADS)

    Bisht, G.; Riley, W. J.

    2016-12-01

    Land surface models (LSMs), which are key components of Earth System Models (ESMs), simulate mass, energy, and nutrient cycles at the surface of the Earth. LSMs are routinely used to study the impact of human activities via land-cover change and increasing CO2 emissions on global climate. Over recent decades, there has been a tremendous growth in the number and complexity of processes incorporated in current generation LSMs. Traditionally, the various physics formulations in LSMs are solved as loosely coupled system of equations, but the importance of solving fully coupled multiphysics problems (e.g., soil-plant-atmosphere continuum, conservation of mass-energy in soil, etc.) is now well recognized. In this work, we develop a framework for solving tightly coupled multi physics problems (MPP). Our framework is built on top of the Portable, Extensible Toolkit for Scientific Computation's (PETSc's) multi-physics coupling capability (DMComposite). One of the main advantages of the MPP framework is the reuse of existing code when adding support for new physics formulations that are solved as a single fully coupled model. Numerical results from a range of multiphysics land surface process representations integrated in the ACME Land Model (ALM) are presented.

  19. Asteroids, comets, Kuiper Belt objects, meteors: the ACM (AKM) 2002 perspective

    NASA Astrophysics Data System (ADS)

    Binzel, Richard P.

    2002-11-01

    An impressionistic overview is given on the state of science of Asteroider, Kometer, Meteorer (AKM), where the Swedish spelling is adopted in recognition of the origin of the ACM conference series. Asteroider (asteroids) are a field that has come of age to the point of asking sophisticated geological and geophysical questions based on dedicated spacecraft missions. Kometer (comets) are coming of age with a strong international emphasis toward new comet missions and ever increasing sophistication of Earth-based observations. K also stands for Kuiper belt objects, a field that wasn't invented when our conference series began but whose inclusion we embrace and recognize as being integral to our science. (Hence the recommendation that we adopt the moniker AKM to proclaim fully our inclusivity) KBOs are an emerging field, perhaps analogous to a fast growing child. The presently known number of KBOs is comparable to the number of known main-belt asteroids in 1900, suggesting that we are just beginning to learn about this region. Meteorer (meteors) is a rejuvenated field that has enjoyed spectacular recent successes in detailed predictions of the Leonid shower and in just recently recording the fall and recovering the Neuschwanstein meteorite. The future outlook portends the greatest advancement in K (kometer and KBOs) with broad interdisciplinary implications.

  20. Selective desulfurization of cysteine in the presence of Cys(Acm) in polypeptides obtained by native chemical ligation.

    PubMed

    Pentelute, Brad L; Kent, Stephen B H

    2007-02-15

    Increased versatility for the synthesis of proteins and peptides by native chemical ligation requires the ability to ligate at positions other than Cys. Here, we report that Raney nickel can be used under standard conditions for the selective desulfurization of Cys in the presence of Cys(Acm). This simple and practical tactic enables the more common Xaa-Ala junctions to be used as ligation sites for the chemical synthesis of Cys-containing peptides and proteins. [reaction: see text].

  1. Geologic, geotechnical, and geophysical properties of core from the Acme Fire-Pit-1 drill hole, Sheridan County, Wyoming

    USGS Publications Warehouse

    Collins, Donley S.

    1983-01-01

    A preliminary core study from the Acme Fire-Pit-1 drill hole, Sheridan County, Wyoming, revealed that the upper portion of the core had been baked by a fire confined to the underlying Monarch coal bed. The baked (clinkered) sediment above the Monarch coal bed was determined to have higher point-load strength values (greater than 2 MPa) than the sediment under the burned coal

  2. ACME-V mission in the North Slope of Alaska (Airborne Carbon MEasurements)

    NASA Astrophysics Data System (ADS)

    Biraud, S.; Torn, M. S.; Sedlacek, A. J., III; Sweeney, C.; Springston, S. R.

    2016-12-01

    Atmospheric temperatures are warming faster in the Arctic than predicted by climate models. The impact of this warming on permafrost degradation is not well understood, but it is projected to increase carbon decomposition and greenhouse gas production (CO2 and/or CH4) by arctic ecosystems. Airborne observations of atmospheric trace gases, aerosols and cloud properties in North Slopes of Alaska (NSA) are improving our understanding of global climate, with the goal of reducing the uncertainty in global and regional climate simulations and projections. From June 1 through September 15, 2015, the Atmospheric radiation measurement (ARM) airborne facility (AAF) deployed a G1 research aircraft (ARM-ACME-V mission) to fly over the North Slope of Alaska, with occasional vertical profiling to measure trace gas concentrations, between Prudhoe Bay, Oliktok point, Barrow, Atqasuk, Ivotuk, and Toolik Lake. The aircraft payload includes a Picarro and a LGR analyzers for continuous measurements of CO2, CH4, H2O, and CO and N2O mixing ratios, and a 12-flask sampler for analysis of carbon cycle gases (CO2, CO, CH4, N2O, 13CO2, 14CO2, carbonyl sulfide, and trace hydrocarbon species including ethane). The aircraft payload also include measurements of aerosol properties (number size distribution, total number concentration, absorption, and scattering), cloud properties (droplet and ice size information), atmospheric thermodynamic state, and solar/infrared radiation. Preliminary results using CO2, CH4, CO, ethane, and soot spectroscopy observations are used to tease apart biogenic and thermogenic (biomass burning, and oil and gas production) contributions.

  3. Segmentation of solid subregion of high grade gliomas in MRI images based on active contour model (ACM)

    NASA Astrophysics Data System (ADS)

    Seow, P.; Win, M. T.; Wong, J. H. D.; Abdullah, N. A.; Ramli, N.

    2016-03-01

    Gliomas are tumours arising from the interstitial tissue of the brain which are heterogeneous, infiltrative and possess ill-defined borders. Tumour subregions (e.g. solid enhancing part, edema and necrosis) are often used for tumour characterisation. Tumour demarcation into substructures facilitates glioma staging and provides essential information. Manual segmentation had several drawbacks that include laborious, time consuming, subjected to intra and inter-rater variability and hindered by diversity in the appearance of tumour tissues. In this work, active contour model (ACM) was used to segment the solid enhancing subregion of the tumour. 2D brain image acquisition data using 3T MRI fast spoiled gradient echo sequence in post gadolinium of four histologically proven high-grade glioma patients were obtained. Preprocessing of the images which includes subtraction and skull stripping were performed and then followed by ACM segmentation. The results of the automatic segmentation method were compared against the manual delineation of the tumour by a trainee radiologist. Both results were further validated by an experienced neuroradiologist and a brief quantitative evaluations (pixel area and difference ratio) were performed. Preliminary results of the clinical data showed the potential of ACM model in the application of fast and large scale tumour segmentation in medical imaging.

  4. Using Satellite- and Ground-Based Simulators to Evaluate the US DOE Climate Model (ACME) Simulated Clouds

    NASA Astrophysics Data System (ADS)

    Zhang, Y.; Xie, S.; Lin, W.; Klein, S. A.; Branstetter, M. L.; Evans, K. J.; Marchand, R.; Kollias, P.; Clothiaux, E. E.

    2016-12-01

    It has been challenging to compare cloud measurements with climate model output because of limitations or features of the observing process. The simulator mimics the instrument view of a narrow atmospheric column by accounting for observational limitations of the instruments, so will facilitate direct comparison of modeled clouds with cloud observations. In this study, we implement the CFMIP (the Cloud-Feedback Model Intercomparison Project) Observation Simulator Package (COSP) and the Atmospheric Radiation Measurement (ARM) radar simulator in the US DOE Accelerated Climate Modeling for Energy (ACME) model and evaluate its simulated clouds. The poster shows preliminary results on using the COSP simulator package to evaluate clouds simulated by ACME at 1 degree and 0.25 degree resolutions in its AMIP runs, as well as using the ARM radar simulator to evaluate clouds in ACME day 2 hindcasts at the ARM Southern Great Plains site. Technical issues with developing the ARM radar simulator are discussed. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  5. Development and first application of an Aerosol Collection Module (ACM) for quasi online compound specific aerosol measurements

    NASA Astrophysics Data System (ADS)

    Hohaus, Thorsten; Kiendler-Scharr, Astrid; Trimborn, Dagmar; Jayne, John; Wahner, Andreas; Worsnop, Doug

    2010-05-01

    Atmospheric aerosols influence climate and human health on regional and global scales (IPCC, 2007). In many environments organics are a major fraction of the aerosol influencing its properties. Due to the huge variety of organic compounds present in atmospheric aerosol current measurement techniques are far from providing a full speciation of organic aerosol (Hallquist et al., 2009). The development of new techniques for compound specific measurements with high time resolution is a timely issue in organic aerosol research. Here we present first laboratory characterisations of an aerosol collection module (ACM) which was developed to allow for the sampling and transfer of atmospheric PM1 aerosol. The system consists of an aerodynamic lens system focussing particles on a beam. This beam is directed to a 3.4 mm in diameter surface which is cooled to -30 °C with liquid nitrogen. After collection the aerosol sample can be evaporated from the surface by heating it to up to 270 °C. The sample is transferred through a 60cm long line with a carrier gas. In order to test the ACM for linearity and sensitivity we combined it with a GC-MS system. The tests were performed with octadecane aerosol. The octadecane mass as measured with the ACM-GC-MS was compared versus the mass as calculated from SMPS derived total volume. The data correlate well (R2 0.99, slope of linear fit 1.1) indicating 100 % collection efficiency. From 150 °C to 270 °C no effect of desorption temperature on transfer efficiency could be observed. The ACM-GC-MS system was proven to be linear over the mass range 2-100 ng and has a detection limit of ~ 2 ng. First experiments applying the ACM-GC-MS system were conducted at the Jülich Aerosol Chamber. Secondary organic aerosol (SOA) was formed from ozonolysis of 600 ppbv of b-pinene. The major oxidation product nopinone was detected in the aerosol and could be shown to decrease from 2 % of the total aerosol to 0.5 % of the aerosol over the 48 hours of

  6. A Prediction of the Damping Properties of Hindered Phenol AO-60/polyacrylate Rubber (AO-60/ACM) Composites through Molecular Dynamics Simulation

    NASA Astrophysics Data System (ADS)

    Yang, Da-Wei; Zhao, Xiu-Ying; Zhang, Geng; Li, Qiang-Guo; Wu, Si-Zhu

    2016-05-01

    Molecule dynamics (MD) simulation, a molecular-level method, was applied to predict the damping properties of AO-60/polyacrylate rubber (AO-60/ACM) composites before experimental measures were performed. MD simulation results revealed that two types of hydrogen bond, namely, type A (AO-60) -OH•••O=C- (ACM), type B (AO-60) - OH•••O=C- (AO-60) were formed. Then, the AO-60/ACM composites were fabricated and tested to verify the accuracy of the MD simulation through dynamic mechanical thermal analysis (DMTA). DMTA results showed that the introduction of AO-60 could remarkably improve the damping properties of the composites, including the increase of glass transition temperature (Tg) alongside with the loss factor (tan δ), also indicating the AO-60/ACM(98/100) had the best damping performance amongst the composites which verified by the experimental.

  7. A functional collagen adhesin gene, acm, in clinical isolates of Enterococcus faecium correlates with the recent success of this emerging nosocomial pathogen.

    PubMed

    Nallapareddy, Sreedhar R; Singh, Kavindra V; Okhuysen, Pablo C; Murray, Barbara E

    2008-09-01

    Enterococcus faecium recently evolved from a generally avirulent commensal into a multidrug-resistant health care-associated pathogen causing difficult-to-treat infections, but little is known about the factors responsible for this change. We previously showed that some E. faecium strains express a cell wall-anchored collagen adhesin, Acm. Here we analyzed 90 E. faecium isolates (99% acm(+)) and found that the Acm protein was detected predominantly in clinically derived isolates, while the acm gene was present as a transposon-interrupted pseudogene in 12 of 47 isolates of nonclinical origin. A highly significant association between clinical (versus fecal or food) origin and collagen adherence (P Acm detected by whole-cell enzyme-linked immunosorbent assay and flow cytometry. Thirty-seven of 41 sera from patients with E. faecium infections showed reactivity with recombinant Acm, while only 4 of 30 community and hospitalized patient control group sera reacted (P Acm were present in all 14 E. faecium endocarditis patient sera. Although pulsed-field gel electrophoresis indicated that multiple strains expressed collagen adherence, multilocus sequence typing demonstrated that the majority of collagen-adhering isolates, as well as 16 of 17 endocarditis isolates, are part of the hospital-associated E. faecium genogroup referred to as clonal complex 17 (CC17), which has emerged globally. Taken together, our findings support the hypothesis that Acm has contributed to the emergence of E. faecium and CC17 in nosocomial infections.

  8. Advanced Development of Certified OS Kernels

    DTIC Science & Technology

    2015-06-01

    DeMillo, R. J. Lipton, and A. J. Perlis. Social processes and proofs of theorems and programs. In Proceedings of the 4th Annual ACM SIGPLAN-SIGACT...X|Ψ| Definition B.80 (Extensions substitution typing) The typing judgement for extensions substitutions is rede - fined as Ψ ` σΨ : Ψ′. The rules are

  9. acme: The Amendable Coal-Fire Modeling Exercise. A C++ Class Library for the Numerical Simulation of Coal-Fires

    NASA Astrophysics Data System (ADS)

    Wuttke, Manfred W.

    2017-04-01

    At LIAG, we use numerical models to develop and enhance understanding of coupled transport processes and to predict the dynamics of the system under consideration. Topics include geothermal heat utilization, subrosion processes, and spontaneous underground coal fires. Although the details make it inconvenient if not impossible to apply a single code implementation to all systems, their investigations go along similar paths: They all depend on the solution of coupled transport equations. We thus saw a need for a modular code system with open access for the various communities to maximize the shared synergistic effects. To this purpose we develop the oops! ( open object-oriented parallel solutions) - toolkit, a C++ class library for the numerical solution of mathematical models of coupled thermal, hydraulic and chemical processes. This is used to develop problem-specific libraries like acme( amendable coal-fire modeling exercise), a class library for the numerical simulation of coal-fires and applications like kobra (Kohlebrand, german for coal-fire), a numerical simulation code for standard coal-fire models. Basic principle of the oops!-code system is the provision of data types for the description of space and time dependent data fields, description of terms of partial differential equations (pde), their discretisation and solving methods. Coupling of different processes, described by their particular pde is modeled by an automatic timescale-ordered operator-splitting technique. acme is a derived coal-fire specific application library, depending on oops!. If specific functionalities of general interest are implemented and have been tested they will be assimilated into the main oops!-library. Interfaces to external pre- and post-processing tools are easily implemented. Thus a construction kit which can be arbitrarily amended is formed. With the kobra-application constructed with acme we study the processes and propagation of shallow coal seam fires in particular in

  10. Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

    PubMed Central

    He, Jun; Chao, William C.H.; Zhang, Ziguo; Yang, Jing; Cronin, Nora; Barford, David

    2013-01-01

    Summary The anaphase-promoting complex/cyclosome (APC/C) regulates sister chromatid segregation and the exit from mitosis. Selection of most APC/C substrates is controlled by coactivator subunits (either Cdc20 or Cdh1) that interact with substrate destruction motifs—predominantly the destruction (D) box and KEN box degrons. How coactivators recognize D box degrons and how this is inhibited by APC/C regulatory proteins is not defined at the atomic level. Here, from the crystal structure of S. cerevisiae Cdh1 in complex with its specific inhibitor Acm1, which incorporates D and KEN box pseudosubstrate motifs, we describe the molecular basis for D box recognition. Additional interactions between Acm1 and Cdh1 identify a third protein-binding site on Cdh1 that is likely to confer coactivator-specific protein functions including substrate association. We provide a structural rationalization for D box and KEN box recognition by coactivators and demonstrate that many noncanonical APC/C degrons bind APC/C coactivators at the D box coreceptor. PMID:23707760

  11. Superfund Record of Decision (EPA Region 5): Acme Solvent Reclaiming, Winnebago County, IL. (Second remedial action), December 1990

    SciTech Connect

    Not Available

    1990-12-31

    The 20-acre Acme Solvent Reclaiming site is a former industrial disposal site in Winnebago County, Illinois. Land use in the area is mixed agricultural and residential. From 1960 to 1973, Acme Solvent Reclaiming disposed of paints, oils, and still bottoms onsite from its solvent reclamation plant. Wastes were dumped into depressions created from previous quarrying and landscaping operations, and empty drums also were stored onsite. State investigations in 1981 identified elevated levels of chlorinated organic compounds in ground water. A 1985 Record of Decision (ROD) provided for excavation and onsite incineration of 26,000 cubic yards of contaminated soil and sludge, supplying home carbon treatment units to affected residences, and further study of ground water and bedrock. During illegal removal actions taken by PRPs in 1986, 40,000 tons of soil and sludge were removed from the site. The selected remedial action for the site includes excavating and treating 6,000 tons of soil and sludge from two waste areas, using low-temperature thermal stripping; treating residuals using solidification, if necessary, followed by onsite or offsite disposal; treating the remaining contaminated soil and possibly bedrock using soil/bedrock vapor extraction; consolidating the remaining contaminated soil onsite with any treatment residuals, followed by capping; incinerating offsite 8,000 gallons of liquids and sludge from two remaining tanks, and disposing of the tanks offsite; providing an alternate water supply to residents with contaminated wells; pumping and onsite treatment of VOC-contaminated ground water.

  12. ACM-based automatic liver segmentation from 3-D CT images by combining multiple atlases and improved mean-shift techniques.

    PubMed

    Ji, Hongwei; He, Jiangping; Yang, Xin; Deklerck, Rudi; Cornelis, Jan

    2013-05-01

    In this paper, we present an autocontext model(ACM)-based automatic liver segmentation algorithm, which combines ACM, multiatlases, and mean-shift techniques to segment liver from 3-D CT images. Our algorithm is a learning-based method and can be divided into two stages. At the first stage, i.e., the training stage, ACM is performed to learn a sequence of classifiers in each atlas space (based on each atlas and other aligned atlases). With the use of multiple atlases, multiple sequences of ACM-based classifiers are obtained. At the second stage, i.e., the segmentation stage, the test image will be segmented in each atlas space by applying each sequence of ACM-based classifiers. The final segmentation result will be obtained by fusing segmentation results from all atlas spaces via a multiclassifier fusion technique. Specially, in order to speed up segmentation, given a test image, we first use an improved mean-shift algorithm to perform over-segmentation and then implement the region-based image labeling instead of the original inefficient pixel-based image labeling. The proposed method is evaluated on the datasets of MICCAI 2007 liver segmentation challenge. The experimental results show that the average volume overlap error and the average surface distance achieved by our method are 8.3% and 1.5 m, respectively, which are comparable to the results reported in the existing state-of-the-art work on liver segmentation.

  13. Techniques for Secure and Reliable Computational Outsourcing

    DTIC Science & Technology

    2013-04-01

    K. Elmagarmid, “Efficient and Practical Ap- proach for Private Record Linkage,” J. Data and Information Quality 3(3): 5 (2012). 6. Ashish Kundu...clustered sequence datasets,” ACM Journal of Experimental Algorithmics 17(1) (2012). 8. Mehdi Bentounsi, Salima Benbernou, Cheikh S. Deme , Mikhail J...probabilities for uncertain data,” Proc. 28th ACM SIGMOD-SIGACT-SIGART Symposium on Principles of Database Systems (PODS 2009), pp. 279-287. 32. Marina

  14. CLIC-ACM: generic modular rad-hard data acquisition system based on CERN GBT versatile link

    NASA Astrophysics Data System (ADS)

    Bielawski, B.; Locci, F.; Magnoni, S.

    2015-01-01

    CLIC is a world-wide collaboration to study the next ``terascale'' lepton collider, relying upon a very innovative concept of two-beam-acceleration. This accelerator, currently under study, will be composed of the subsequence of 21000 two-beam-modules. Each module requires more than 300 analogue and digital signals which need to be acquired and controlled in a synchronous way. CLIC-ACM (Acquisition and Control Module) is the 'generic' control and acquisition module developed to accommodate the controls of all these signals for various sub-systems and related specification in term of data bandwidth, triggering and timing synchronization. This paper describes the system architecture with respect to its radiation-tolerance, power consumption and scalability.

  15. Annual evaporite deposition at the acme of the Messinian salinity crisis: evidence for solar-lunar climate forcing

    NASA Astrophysics Data System (ADS)

    Manzi, Vinicio; Gennari, Rocco; Lugli, Stefano; Roveri, Marco; Scafetta, Nicola; Schreiber, B. Charlotte

    2013-04-01

    We studied two evaporite successions (one halite and the other gypsum) consisting of annual varves in order to reconstruct the paleoclimatic and paleoenvironmental conditions existing during the acme of the Messinian salinity crisis (MSC; ≈5.5 Ma), when huge volumes of evaporites accumulated on the floor of the Mediterranean basin. The spectral analyses of these varved evaporitic successions reveal significant peaks in periodicity at around 3-5, 9, 11-13, 20-27 and 50-100 yr. The deposition of varved sedimentary deposits is usually controlled by climate conditions. A comparison with modern precipitation data in the western Mediterranean shows that during the acme of the MSC the climate was not in a permanent evaporitic stage, but in a dynamic state where evaporite deposition was controlled by quasi-periodic climate oscillations similar to modern analogs including Quasi-Biennial Oscillation, El Niño Southern Oscillation, and decadal to secular lunar- and solar-induced cycles. Particularly, we found a significant quasi-decadal oscillation with a prominent 9-year peak that is also common in modern temperature records and is present in both the contemporary Atlantic Multidecadal Oscillation (AMO) index and Pacific Decadal Oscillation (PDO) index. These cyclical patterns are common to both ancient and modern climate records because they can be associated with solar and solar-lunar tidal cycles. During the Messinian, the Mediterranean basin as well as the global ocean, were characterized by somewhat different continent distribution, ocean size, geography, hydrological connections, and ice-sheet volume with respect to the modern configuration. The recognition of modern-style climate oscillations during the Messinian, however, suggests that, although local geographic factors acted as pre-conditioning factors turning the Mediterranean Sea into a giant brine pool, external climate forcing, regulated by solar-lunar cycles and largely independent of those local geographic

  16. Characterization of PVL/ACME-positive methicillin-resistant Staphylococcus aureus (genotypes ST8-MRSA-IV and ST5-MRSA-II) isolated from a university hospital in Japan.

    PubMed

    Kawaguchiya, Mitsuyo; Urushibara, Noriko; Yamamoto, Dai; Yamashita, Toshiharu; Shinagawa, Masaaki; Watanabe, Naoki; Kobayashi, Nobumichi

    2013-02-01

    The ST8 methicillin-resistant Staphylococcus aureus (MRSA) with Staphylococcal cassette chromosome mec (SCCmec) type IVa, known as USA300, is a prevalent community-acquired MRSA (CA-MRSA) clone in the United States and has been spreading worldwide. The USA300 characteristically harbors Panton-Valentine Leukocidin (PVL) genes and the arginine catabolic mobile element (ACME, type I). Prevalence and molecular characteristics of PVL(+) and/or ACME(+) S. aureus were investigated in a university hospital located in northern Japan, for 1,366 S. aureus isolates, including 601 MRSA strains derived from clinical specimens collected from 2008 to 2010. The PVL gene was identified in three MRSA strains with SCCmec IV, which belonged to ST8, spa type t008, coagulase type III, and agr type I. Two PVL-positive MRSA strains had also type I ACME, and were isolated from skin abscess of outpatients who have not travelled abroad recently. One of these PVL(+)/ACME(+) strains carried tet(K), msrA, and aph(3')-IIIa, showing resistance to kanamycin, tetracycline, erythromycin, and ciprofloxacin, suggesting acquisition of more resistance than ST8 CA-MRSA reported in Japan previously. In contrast, another PVL(+)/ACME(+) strain and a PVL(+)/ACME(-) strain were susceptible to more antimicrobials and had less virulence factors than PVL(-)/ACME(+) MRSA strains. Besides the two PVL(+) MRSA strains, ACME (type-ΔII) was identified into seven MRSA strains with SCCmec II belonging to ST5, one of the three spa types (t002, t067, and t071), coagulase type II, and agr type II. These PVL(-)/ACME(+) MRSA strains showed multiple drug resistance and harbored various toxin genes as observed for ST5 PVL(-)/ACME(-) MRSA-II. The present study suggested the spread of ST8-MRSA-IV in northern Japan, and a potential significance of ACME-positive ST5-MRSA-II as an emerging MRSA clone in a hospital.

  17. Proceeding of the ACM/IEEE-CS Joint Conference on Digital Libraries (1st, Roanoke, Virginia, June 24-28, 2001).

    ERIC Educational Resources Information Center

    Association for Computing Machinery, New York, NY.

    Papers in this Proceedings of the ACM/IEEE-CS Joint Conference on Digital Libraries (Roanoke, Virginia, June 24-28, 2001) discuss: automatic genre analysis; text categorization; automated name authority control; automatic event generation; linked active content; designing e-books for legal research; metadata harvesting; mapping the…

  18. On the modeling of a single-stage, entrained-flow gasifier using Aspen Custom Modeler (ACM)

    SciTech Connect

    Kasule, J.; Turton, R.; Bhattacharyya, D.; Zitney, S.

    2010-01-01

    Coal-fired gasifiers are the centerpiece of integrated gasification combined cycle (IGCC) power plants. The gasifier produces synthesis gas that is subsequently converted into electricity through combustion in a gas turbine. Several mathematical models have been developed to study the physical and chemical processes taking place inside the gasifier. Such models range from simple one-dimensional (1D) steady-state models to sophisticated dynamic 3D computational fluid dynamics (CFD) models that incorporate turbulence effects in the reactor. The practical operation of the gasifier is dynamic in nature but most 1D and some higher-dimensional models are often steady state. On the other hand, many higher order CFD-based models are dynamic in nature, but are too computationally expensive to be used directly in operability and controllability dynamic studies. They are also difficult to incorporate in the framework of process simulation software such as Aspen Plus Dynamics. Thus lower-dimensional dynamic models are still useful in these types of studies. In the current study, a 1D dynamic model for a single-stage, downward-firing, entrained-flow GE-type gasifier is developed using Aspen Custom Modeler{reg_sign} (ACM), which is a commercial equation-based simulator for creating, editing, and re-using models of process units. The gasifier model is based on mass, momentum, and energy balances for the solid and gas phases. The physical and chemical reactions considered in the model are drying, devolatilization/pyrolysis, gasification, combustion, and the homogeneous gas phase reactions. The dynamic gasifier model is being developed for use in a plant-wide dynamic model of an IGCC power plant. For dynamic simulation, the resulting highly nonlinear system of partial differential algebraic equations (PDAE) is solved in ACM using the well-known Method of Lines (MoL) approach. The MoL discretizes the space domain and leaves the time domain continuous, thereby converting the PDAE to

  19. Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients.

    PubMed

    Schmid, T E; Brinkworth, M H; Hill, F; Sloter, E; Kamischke, A; Marchetti, F; Nieschlag, E; Wyrobek, A J

    2004-06-01

    Modern reproductive technologies are enabling the treatment of infertile men with severe disturbances of spermatogenesis. The possibility of elevated frequencies of genetically and chromosomally defective sperm has become an issue of concern with the increased usage of ICSI, which can enable men with severely impaired sperm production to father children. Several papers have been published reporting aneuploidy in oligozoospermic patients, but relatively little is known about chromosome structural aberrations in the sperm of these patients. We examined sperm from infertile, oligozoospermic individuals for structural and numerical chromosomal abnormalities using a multicolour ACM fluorescence in situ hybridization (FISH) assay that utilizes DNA probes specific for three regions of chromosome 1 to detect human sperm that carry numerical chromosomal abnormalities plus two categories of structural aberrations: duplications and deletions of 1pter and 1cen, and chromosomal breaks within the 1cen-1q12 region. There was a significant increase in the average frequencies of sperm with duplications and deletions in the infertility patients compared with the healthy concurrent controls. There was also a significantly elevated level of breaks within the 1cen-1q12 region. There was no evidence for an increase in chromosome 1 disomy, or in diploidy. Our data reveal that oligozoospermia is associated with chromosomal structural abnormalities, suggesting that oligozoospermic men carry a higher burden of transmissible, chromosome damage. The findings raise the possibility of elevated levels of transmissible chromosomal defects following ICSI treatment.

  20. Human factors in computing systems: focus on patient-centered health communication at the ACM SIGCHI conference.

    PubMed

    Wilcox, Lauren; Patel, Rupa; Chen, Yunan; Shachak, Aviv

    2013-12-01

    Health Information Technologies, such as electronic health records (EHR) and secure messaging, have already transformed interactions among patients and clinicians. In addition, technologies supporting asynchronous communication outside of clinical encounters, such as email, SMS, and patient portals, are being increasingly used for follow-up, education, and data reporting. Meanwhile, patients are increasingly adopting personal tools to track various aspects of health status and therapeutic progress, wishing to review these data with clinicians during consultations. These issues have drawn increasing interest from the human-computer interaction (HCI) community, with special focus on critical challenges in patient-centered interactions and design opportunities that can address these challenges. We saw this community presenting and interacting at the ACM SIGCHI 2013, Conference on Human Factors in Computing Systems, (also known as CHI), held April 27-May 2nd, 2013 at the Palais de Congrès de Paris in France. CHI 2013 featured many formal avenues to pursue patient-centered health communication: a well-attended workshop, tracks of original research, and a lively panel discussion. In this report, we highlight these events and the main themes we identified. We hope that it will help bring the health care communication and the HCI communities closer together.

  1. A multicopper oxidase is essential for manganese oxidation and laccase-like activity in Pedomicrobium sp. ACM 3067.

    PubMed

    Ridge, Justin P; Lin, Marianne; Larsen, Eloise I; Fegan, Mark; McEwan, Alastair G; Sly, Lindsay I

    2007-04-01

    Pedomicrobium sp. ACM 3067 is a budding-hyphal bacterium belonging to the alpha-Proteobacteria which is able to oxidize soluble Mn2+ to insoluble manganese oxide. A cosmid, from a whole-genome library, containing the putative genes responsible for manganese oxidation was identified and a primer-walking approach yielded 4350 bp of novel sequence. Analysis of this sequence showed the presence of a predicted three-gene operon, moxCBA. The moxA gene product showed homology to multicopper oxidases (MCOs) and contained the characteristic four copper-binding motifs (A, B, C and D) common to MCOs. An insertion mutation of moxA showed that this gene was essential for both manganese oxidation and laccase-like activity. The moxB gene product showed homology to a family of outer membrane proteins which are essential for Type I secretion in Gram-negative bacteria. moxBA has not been observed in other manganese-oxidizing bacteria but homologues were identified in the genomes of several bacteria including Sinorhizobium meliloti 1021 and Agrobacterium tumefaciens C58. These results suggest that moxBA and its homologues constitute a family of genes encoding an MCO and a predicted component of the Type I secretion system.

  2. Detection of structural and numerical chomosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients

    SciTech Connect

    Schmid, T E; Brinkworth, M H; Hill, F; Sloter, E; Kamischke, A; Marchetti, F; Nieschlag, E; Wyrobek, A J

    2003-11-10

    Modern reproductive technologies are enabling the treatment of infertile men with severe disturbances of spermatogenesis. The possibility of elevated frequencies of genetically and chromosomally defective sperm has become an issue of concern with the increased usage of intracytoplasmic sperm injection (ICSI), which can enable men with severely impaired sperm production to father children. Several papers have been published about aneuploidy in oligozoospermic patients, but relatively little is known about chromosome structural aberrations in the sperm of these patients. We examined sperm from infertile, oligozoospermic individuals for structural and numerical chromosomal abnormalities using a multicolor ACM FISH assay that utilizes DNA probes specific for three regions of chromosome 1 to detect human sperm that carry numerical chromosomal abnormalities plus two categories of structural aberrations: duplications and deletions of 1pter and 1cen, and chromosomal breaks within the 1cen-1q12 region. There was a significant increase in the average frequencies of sperm with duplications and deletions in the infertility patients compared with the healthy concurrent controls. There was also a significantly elevated level of breaks within the 1cen-1q12 region. There was no evidence for an increase in chromosome-1 disomy, or in diploidy. Our data reveal that oligozoospermia is associated with chromosomal structural abnormalities suggesting that, oligozoospermic men carry a higher burden of transmissible, chromosome damage. The findings raise the possibility of elevated levels of transmissible chromosomal defects following ICSI treatment.

  3. Mechanisms of stochastic focusing and defocusing in biological reaction networks: insight from accurate chemical master equation (ACME) solutions.

    PubMed

    Gursoy, Gamze; Terebus, Anna; Youfang Cao; Jie Liang

    2016-08-01

    Stochasticity plays important roles in regulation of biochemical reaction networks when the copy numbers of molecular species are small. Studies based on Stochastic Simulation Algorithm (SSA) has shown that a basic reaction system can display stochastic focusing (SF) by increasing the sensitivity of the network as a result of the signal noise. Although SSA has been widely used to study stochastic networks, it is ineffective in examining rare events and this becomes a significant issue when the tails of probability distributions are relevant as is the case of SF. Here we use the ACME method to solve the exact solution of the discrete Chemical Master Equations and to study a network where SF was reported. We showed that the level of SF depends on the degree of the fluctuations of signal molecule. We discovered that signaling noise under certain conditions in the same reaction network can lead to a decrease in the system sensitivities, thus the network can experience stochastic defocusing. These results highlight the fundamental role of stochasticity in biological reaction networks and the need for exact computation of probability landscape of the molecules in the system.

  4. Hydrologic effects of phreatophyte control, Acme-Artesia reach of the Pecos River, New Mexico, 1967-82

    USGS Publications Warehouse

    Welder, G.E.

    1988-01-01

    The U.S. Bureau of Reclamation began a phreatophyte clearing and control program in the bottom land of the Acme-Artesia reach of the Pecos River in March 1967. The initial cutting of 19,000 acres of saltcedar trees, the dominant phreatophyte in the area, was completed in May 1969. Saltcedar regrowth continued each year until July 1975, when root plowing eradicated most of the regrowth. The major objective of the clearing and control program was to salvage water that could be put to beneficial use. Measurements of changes in the water table in the bottom land and changes in the base flow of the Pecos River were made in order to determine the hydrologic effects of the program. Some salvage of water was indicated, but it is not readily recognized as an increase in base flow. The quantity of salvage probably is less than the average annual base-flow gain of 19 ,110 acre-ft in the reach during 1967-82. (Author 's abstract)

  5. WTP Calculation Sheet: Determining the LAW Glass Former Constituents and Amounts for G2 and Acm Models. 24590-LAW-M4C-LFP-00002, Rev. B

    SciTech Connect

    Gimpel, Rodney F.; Kruger, Albert A.

    2013-12-16

    The purpose of this calculation is to determine the LAW glass former recipe and additives with their respective amounts. The methodology and equations contained herein are to be used in the G2 and ACM models until better information is supplied by R&T efforts. This revision includes calculations that determines the mass and volume of the bulk chemicals/minerals needed per batch. Plus, it contains calculations (for the G2 model) to help prevent overflow in LAW Feed Preparation Vessel.

  6. High-resolution, Antarctic Ice Sheet simulations forced by submarine melting simulated by the Accelerated Climate Model for Energy (ACME)

    NASA Astrophysics Data System (ADS)

    Price, S. F.; Asay-Davis, X.; Fyke, J. G.; Hoffman, M. J.; Jacobson, D.; Petersen, M. R.; Tezaur, I.; Perego, M.; Salinger, A.; Turner, A. K.; Wolfe, J.

    2016-12-01

    The capability for simulating sub-ice shelf circulation and submarine melting and freezing has recently been added to the U.S. Department of Energy's Accelerated Climate Model for Energy (ACME). With this new capability, we use an eddy permitting ocean model to conduct two sets of simulations in the spirit of Spence et al. (GRL, 41, 2014), who demonstrate increased warm water upwelling along the Antarctic coast in response to poleward shifting and strengthening of Southern Ocean westerly winds. These characteristics, symptomatic of a positive Southern Annual Model (SAM), are projected to continue into the 21st century under anthropogenic climate change (Fyfe et al., J. Clim., 20, 2007). In our first simulation, we force our climate model using repeat cycles of the standard CORE interannual forcing dataset (Large and Yeager; Clim. Dyn., 33, 2009). These melt rates are used to force our high-resolution (30-to-1 km) ice sheet model, MPAS-Land Ice, offline and to derive a quasi-steady state ice sheet model initial condition. In our second simulation, we force our climate model using an altered version of CORE interannual forcing, based on the latter half of the full time series, which we take as a proxy for a future climate state biased towards a positive SAM. Melt rate anomalies from this second simulation are then used to force our ice sheet model offline out to year 2100. We compare ocean model states and sub-ice shelf melt rates with observations and present estimates for Antarctic Ice Sheet mass loss from our simulations.

  7. Significant impacts of irrigation water sources and methods on modeling irrigation effects in the ACME Land Model

    DOE PAGES

    Leng, Guoyong; Leung, Lai-Yung; Huang, Maoyi

    2017-07-01

    An irrigation module that considers both irrigation water sources and irrigation methods has been incorporated into the ACME Land Model (ALM). Global numerical experiments were conducted to evaluate the impacts of irrigation water sources and irrigation methods on the simulated irrigation effects. All simulations shared the same irrigation soil moisture target constrained by a global census dataset of irrigation amounts. Irrigation has large impacts on terrestrial water balances especially in regions with extensive irrigation. Such effects depend on the irrigation water sources: surface-water-fed irrigation leads to decreases in runoff and water table depth, while groundwater-fed irrigation increases water table depth,more » with positive or negative effects on runoff depending on the pumping intensity. Irrigation effects also depend significantly on the irrigation methods. Flood irrigation applies water in large volumes within short durations, resulting in much larger impacts on runoff and water table depth than drip and sprinkler irrigations. Differentiating the irrigation water sources and methods is important not only for representing the distinct pathways of how irrigation influences the terrestrial water balances, but also for estimating irrigation water use efficiency. Specifically, groundwater pumping has lower irrigation water use efficiency due to enhanced recharge rates. Different irrigation methods also affect water use efficiency, with drip irrigation the most efficient followed by sprinkler and flood irrigation. Our results highlight the importance of explicitly accounting for irrigation sources and irrigation methods, which are the least understood and constrained aspects in modeling irrigation water demand, water scarcity and irrigation effects in Earth System Models.« less

  8. A 90-day subchronic feeding study of genetically modified maize expressing Cry1Ac-M protein in Sprague-Dawley rats.

    PubMed

    Liu, Pengfei; He, Xiaoyun; Chen, Delong; Luo, Yunbo; Cao, Sishuo; Song, Huan; Liu, Ting; Huang, Kunlun; Xu, Wentao

    2012-09-01

    The cry1Ac-M gene, coding one of Bacillus thuringiensis (Bt) crystal proteins, was introduced into maize H99 × Hi IIB genome to produce insect-resistant GM maize BT-38. The food safety assessment of the BT-38 maize was conducted in Sprague-Dawley rats by a 90-days feeding study. We incorporated maize grains from BT-38 and H99 × Hi IIB into rodent diets at three concentrations (12.5%, 25%, 50%) and administered to Sprague-Dawley rats (n=10/sex/group) for 90 days. A commercialized rodent diet was fed to an additional group as control group. Body weight, feed consumption and toxicological response variables were measured, and gross as well as microscopic pathology were examined. Moreover, detection of residual Cry1Ac-M protein in the serum of rats fed with GM maize was conducted. No death or adverse effects were observed in the current feeding study. No adverse differences in the values of the response variables were observed between rats that consumed diets containing GM maize BT-38 and non-GM maize H99 × Hi IIB. No detectable Cry1Ac-M protein was found in the serum of rats after feeding diets containing GM maize for 3 months. The results demonstrated that BT-38 maize is as safe as conventional non-GM maize.

  9. Prescriptions for ACME's Future.

    ERIC Educational Resources Information Center

    Felch, William Campbell

    1991-01-01

    Five prescriptions for the future agenda of the Alliance for Continuing Medical Education are (1) a core curriculum; (2) informatics; (3) remedial continuing medical education (CME); (4) focus on the individual learner; and (5) practice-oriented CME. (SK)

  10. Acme Landfill Expansion. Appendices.

    DTIC Science & Technology

    1982-01-01

    connected to that supply shall be clearly labeled in English, "Polluted-Not Safe For Human Use", and Spanish, "Peligro, Contaminacion , No Usar". 7. Public...8217 Grab0, smiz1lc quarterly’ watur le~vel f -Vt Stationls throu(’,iout Lhe year Col or visual chloride 1. ’i tira te D i trolyen u)j/ K j : 1d;d 1 .1j/ J i t

  11. Representing carbon, nitrogen, and phosphorus interaction in the ACME Land Model v1: model development and global benchmarking

    NASA Astrophysics Data System (ADS)

    Zhu, Q.; Riley, W. J.; Tang, J.; Hoffman, F. M.; Mu, M.; Randerson, J. T.

    2016-12-01

    Since nutrient limitations of the terrestrial carbon cycle have been rigorously demonstrated by field experiments (e.g., fertilization experiments), various Earth System Model (ESM) groups have spent substantial effort to incorporate nutrient sub-models in their terrestrial carbon cycle models (e.g., CLM-CNP, JSBACH-CNP, CABLE-CNP). Here we report new developments in the Accelerated Climate Modeling for Energy (ACME) Land Model (ALMv1) regarding carbon-nutrient interactions. The development is based on (1) recent theoretical advances in understanding belowground multiple-consumer, multiple-nutrient competition; (2) a dynamic allocation scheme based on resources availability to balance whole system functioning; and (3) global datasets of plant physiological traits (e.g., TRY database). In addition to describing these developments, we compare them with representations in other ESM land models. We demonstrate that these new ALMv1 developments accurately reproduce present terrestrial carbon dynamics under the constraints of nitrogen and phosphorus availability. We benchmark the new model using the International Land Model Benchmarking package (ILAMB) for major plant and soil carbon pools (total vegetation biomass, soil carbon content) and fluxes (GPP, NEP) and leaf area index (LAI). The results show that biases have been significantly reduced (e.g., GPP bias in boreal needle leaf forests, LAI bias in tropical broad leaf evergreen forests). The ILAMB benchmarks provide a unique opportunity to consistently track ongoing model development and simultaneously demonstrate improvements for multiple variables. We further benchmark the new model transient response to nutrient perturbation, using nitrogen and phosphorus fertilization experiments at over 100 forest sites. We found that the plant productivity response ratio ((NPPfert - NPPcontrol)/ NPPcontrol) could be captured only when the whole system functional balance is taken into account. Compared with other candidate

  12. Experimental determination of the partitioning coefficient and volatility of important BVOC oxidation products using the Aerosol Collection Module (ACM) coupled to a PTR-ToF-MS

    NASA Astrophysics Data System (ADS)

    Gkatzelis, G.; Hohaus, T.; Tillmann, R.; Schmitt, S. H.; Yu, Z.; Schlag, P.; Wegener, R.; Kaminski, M.; Kiendler-Scharr, A.

    2015-12-01

    Atmospheric aerosol can alter the Earth's radiative budget and global climate but can also affect human health. A dominant contributor to the submicrometer particulate matter (PM) is organic aerosol (OA). OA can be either directly emitted through e.g. combustion processes (primary OA) or formed through the oxidation of organic gases (secondary organic aerosol, SOA). A detailed understanding of SOA formation is of importance as it constitutes a major contribution to the total OA. The partitioning between the gas and particle phase as well as the volatility of individual components of SOA is yet poorly understood adding uncertainties and thus complicating climate modelling. In this work, a new experimental methodology was used for compound-specific analysis of organic aerosol. The Aerosol Collection Module (ACM) is a newly developed instrument that deploys an aerodynamic lens to separate the gas and particle phase of an aerosol. The particle phase is directed to a cooled sampling surface. After collection particles are thermally desorbed and transferred to a detector for further analysis. In the present work, the ACM was coupled to a Proton Transfer Reaction-Time of Flight-Mass Spectrometer (PTR-ToF-MS) to detect and quantify organic compounds partitioning between the gas and particle phase. This experimental approach was used in a set of experiments at the atmosphere simulation chamber SAPHIR to investigate SOA formation. Ozone oxidation with subsequent photochemical aging of β-pinene, limonene and real plant emissions from Pinus sylvestris (Scots pine) were studied. Simultaneous measurement of the gas and particle phase using the ACM-PTR-ToF-MS allows to report partitioning coefficients of important BVOC oxidation products. Additionally, volatility trends and changes of the SOA with photochemical aging are investigated and compared for all systems studied.

  13. Design of ET(B) receptor agonists: NMR spectroscopic and conformational studies of ET7-21[Leu7, Aib11, Cys(Acm)15].

    PubMed

    Hewage, Chandralal M; Jiang, Lu; Parkinson, John A; Ramage, Robert; Sadler, Ian H

    2002-03-01

    In a previous report we have shown that the endothelin-B receptor-selective linear endothelin peptide, ET-1[Cys (Acm)1,15, Ala3, Leu7, Aib11], folds into an alpha-helical conformation in a methanol-d3/water co-solvent [Hewage et al. (1998) FEBS Lett., 425, 234-238]. To study the requirements for the structure-activity relationships, truncated analogues of this peptide were subjected to further studies. Here we report the solution conformation of ET7-21[Leu7, Aib11, Cys(Acm)15], in a methanol-d3/water co-solvent at pH 3.6, by NMR spectroscopic and molecular modelling studies. Further truncation of this short peptide results in it displaying poor agonist activity. The modelled structure shows that the peptide folds into an alpha-helical conformation between residues Lys9-His16, whereas the C-terminus prefers no fixed conformation. This truncated linear endothelin analogue is pivotal for designing endothelin-B receptor agonists.

  14. Evidence for heterogeneity of astrocyte de-differentiation in vitro: astrocytes transform into intermediate precursor cells following induction of ACM from scratch-insulted astrocytes.

    PubMed

    Yang, Hao; Qian, Xin-Hong; Cong, Rui; Li, Jing-wen; Yao, Qin; Jiao, Xi-Ying; Ju, Gong; You, Si-Wei

    2010-04-01

    Our previous study definitely demonstrated that the mature astrocytes could undergo a de-differentiation process and further transform into pluripotential neural stem cells (NSCs), which might well arise from the effect of diffusible factors released from scratch-insulted astrocytes. However, these neurospheres passaged from one neurosphere-derived from de-differentiated astrocytes possessed a completely distinct characteristic in the differentiation behavior, namely heterogeneity of differentiation. The heterogeneity in cell differentiation has become a crucial but elusive issue. In this study, we show that purified astrocytes could de-differentiate into intermediate precursor cells (IPCs) with addition of scratch-insulted astrocyte-conditioned medium (ACM) to the culture, which can express NG2 and A2B5, the IPCs markers. Apart from the number of NG2(+) and A2B5(+) cells, the percentage of proliferative cells as labeled with BrdU progressively increased with prolonged culture period ranging from 1 to 10 days. Meanwhile, the protein level of A2B5 in cells also increased significantly. These results revealed that not all astrocytes could de-differentiate fully into NSCs directly when induced by ACM, rather they generated intermediate or more restricted precursor cells that might undergo progressive de-differentiation to generate NSCs.

  15. Enterococcus faecium biofilm formation: identification of major autolysin AtlAEfm, associated Acm surface localization, and AtlAEfm-independent extracellular DNA Release.

    PubMed

    Paganelli, Fernanda L; Willems, Rob J L; Jansen, Pamela; Hendrickx, Antoni; Zhang, Xinglin; Bonten, Marc J M; Leavis, Helen L

    2013-04-16

    Enterococcus faecium is an important multidrug-resistant nosocomial pathogen causing biofilm-mediated infections in patients with medical devices. Insight into E. faecium biofilm pathogenesis is pivotal for the development of new strategies to prevent and treat these infections. In several bacteria, a major autolysin is essential for extracellular DNA (eDNA) release in the biofilm matrix, contributing to biofilm attachment and stability. In this study, we identified and functionally characterized the major autolysin of E. faecium E1162 by a bioinformatic genome screen followed by insertional gene disruption of six putative autolysin genes. Insertional inactivation of locus tag EfmE1162_2692 resulted in resistance to lysis, reduced eDNA release, deficient cell attachment, decreased biofilm, decreased cell wall hydrolysis, and significant chaining compared to that of the wild type. Therefore, locus tag EfmE1162_2692 was considered the major autolysin in E. faecium and renamed atlAEfm. In addition, AtlAEfm was implicated in cell surface exposure of Acm, a virulence factor in E. faecium, and thereby facilitates binding to collagen types I and IV. This is a novel feature of enterococcal autolysins not described previously. Furthermore, we identified (and localized) autolysin-independent DNA release in E. faecium that contributes to cell-cell interactions in the atlAEfm mutant and is important for cell separation. In conclusion, AtlAEfm is the major autolysin in E. faecium and contributes to biofilm stability and Acm localization, making AtlAEfm a promising target for treatment of E. faecium biofilm-mediated infections. IMPORTANCE Nosocomial infections caused by Enterococcus faecium have rapidly increased, and treatment options have become more limited. This is due not only to increasing resistance to antibiotics but also to biofilm-associated infections. DNA is released in biofilm matrix via cell lysis, caused by autolysin, and acts as a matrix stabilizer. In this study

  16. Polynomial End-to-End Communication

    DTIC Science & Technology

    1989-08-01

    the "fail-stop model" in [AM88]. As mentioned in the introduction, our motivation here is to deal with networks frequently changing topology. In such...eventually connected edges among nodes. By Q4, there is no cut between the receiver and sender in G’. It is known, from graph theory , that if is there is no...Computing, Toronto, Ontario, Canada, pages 131-148, ACM SIGACT and SIGOPS, ACM, 1988. 22 [AGH89] Baruch Awerbuch, Oded Goldreich, and Amir Herzberg . A

  17. Construction of improved temperature-sensitive and mobilizable vectors and their use for constructing mutations in the adhesin-encoding acm gene of poorly transformable clinical Enterococcus faecium strains.

    PubMed

    Nallapareddy, Sreedhar R; Singh, Kavindra V; Murray, Barbara E

    2006-01-01

    Inactivation by allelic exchange in clinical isolates of the emerging nosocomial pathogen Enterococcus faecium has been hindered by lack of efficient tools, and, in this study, transformation of clinical isolates was found to be particularly problematic. For this reason, a vector for allelic replacement (pTEX5500ts) was constructed that includes (i) the pWV01-based gram-positive repAts replication region, which is known to confer a high degree of temperature intolerance, (ii) Escherichia coli oriR from pUC18, (iii) two extended multiple-cloning sites located upstream and downstream of one of the marker genes for efficient cloning of flanking regions for double-crossover mutagenesis, (iv) transcriptional terminator sites to terminate undesired readthrough, and (v) a synthetic extended promoter region containing the cat gene for allelic exchange and a high-level gentamicin resistance gene, aph(2'')-Id, to distinguish double-crossover recombination, both of which are functional in gram-positive and gram-negative backgrounds. To demonstrate the functionality of this vector, the vector was used to construct an acm (encoding an adhesin to collagen from E. faecium) deletion mutant of a poorly transformable multidrug-resistant E. faecium endocarditis isolate, TX0082. The acm-deleted strain, TX6051 (TX0082Deltaacm), was shown to lack Acm on its surface, which resulted in the abolishment of the collagen adherence phenotype observed in TX0082. A mobilizable derivative (pTEX5501ts) that contains oriT of Tn916 to facilitate conjugative transfer from the transformable E. faecalis strain JH2Sm::Tn916 to E. faecium was also constructed. Using this vector, the acm gene of a nonelectroporable E. faecium wound isolate was successfully interrupted. Thus, pTEX5500ts and its mobilizable derivative demonstrated their roles as important tools by helping to create the first reported allelic replacement in E. faecium; the constructed this acm deletion mutant will be useful for assessing the

  18. Spin–orbit torque switching in MgO/CoFeB/Ta/CoFeB/MgO heterostructures with a critical current density of 105 A/cm2

    NASA Astrophysics Data System (ADS)

    Shi, Guoyi; Chang, Yuansi; Cai, Jianwang; Zhang, Pengxiang; Pan, Feng; Song, Cheng

    2017-10-01

    Spin–orbit torque-induced magnetization switching in heavy metal/ferromagnetic metal/oxide heterostructures has been extensively studied. However, thus far, the critical current density for magnetization switching in these systems is at least ∼106 A/cm2. Here, we investigate the spin–orbit torque switching in a substrate/MgO/CoFeB/Ta/CoFeB/MgO structure where the upper CoFeB layer exhibits a strong perpendicular magnetic anisotropy in contrast to the relatively weak perpendicular anisotropy in the lower CoFeB layer. By varying the thickness of Ta, we observe that the critical current required for switching differs markedly. Specifically, for the sample with a 3-nm-thick Ta layer, with an external field of 100 Oe applied along the current direction to break the symmetry, the critical current density is ∼2 × 105 A/cm2. This could be ascribed to the minimum coercivity and perpendicular anisotropic field in the sample with a 3-nm-thick Ta layer.

  19. Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that respond differently to [Cys(Acm)(2,7)] calcitonin gene-related peptide and CGRP(8-37).

    PubMed

    Kawase, Tomoyuki; Okuda, Kazuhiro; Burns, Douglas M

    2005-10-01

    Calcitonin gene-related peptide (CGRP) is clearly an anabolic factor in skeletal tissue, but the distribution of CGRP receptor (CGRPR) subtypes in osteoblastic cells is poorly understood. We previously demonstrated that the CGRPR expressed in osteoblastic MG63 cells does not match exactly the known characteristics of the classic subtype 1 receptor (CGRPR1). The aim of the present study was to further characterize the MG63 CGRPR using a selective agonist of the putative CGRPR2, [Cys(Acm)(2,7)]CGRP, and a relatively specific antagonist of CGRPR1, CGRP(8-37). [Cys(Acm)(2,7)]CGRP acted as a significant agonist only upon ERK dephosphorylation, whereas this analog effectively antagonized CGRP-induced cAMP production and phosphorylation of cAMP response element-binding protein (CREB) and p38 MAPK. Although it had no agonistic action when used alone, CGRP(8-37) potently blocked CGRP actions on cAMP, CREB, and p38 MAPK but had less of an effect on ERK. Schild plot analysis of the latter data revealed that the apparent pA2 value for ERK is clearly distinguishable from those of the other three plots as judged using the 95% confidence intervals. Additional assays using 3-isobutyl-1-methylxanthine or the PKA inhibitor N-(2-[p-bromocinnamylamino]ethyl)-5-isoquinolinesulfonamide hydrochloride (H-89) indicated that the cAMP-dependent pathway was predominantly responsible for CREB phosphorylation, partially involved in ERK dephosphorylation, and not involved in p38 MAPK phosphorylation. Considering previous data from Scatchard analysis of [125I]CGRP binding in connection with these results, these findings suggest that MG63 cells possess two functionally distinct CGRPR subtypes that show almost identical affinity for CGRP but different sensitivity to CGRP analogs: one is best characterized as a variation of CGRPR1, and the second may be a novel variant of CGRPR2.

  20. The effect of changing wind forcing on Antarctic ice shelf melting in high-resolution, global sea ice-ocean simulations with the Accelerated Climate Model for Energy (ACME)

    NASA Astrophysics Data System (ADS)

    Asay-Davis, Xylar; Price, Stephen; Petersen, Mark; Wolfe, Jonathan

    2017-04-01

    The capability for simulating sub-ice shelf circulation and submarine melting and freezing has recently been added to the U.S. Department of Energy's Accelerated Climate Model for Energy (ACME). With this new capability, we use an eddy permitting ocean model to conduct two sets of simulations in the spirit of Spence et al. (GRL, 41, 2014), who demonstrate increased warm water upwelling along the Antarctic coast in response to poleward shifting and strengthening of Southern Ocean westerly winds. These characteristics, symptomatic of a positive Southern Annular Mode (SAM), are projected to continue into the 21st century under anthropogenic climate change (Fyfe et al., J. Clim., 20, 2007). In our first simulation, we force the climate model using the standard CORE interannual forcing dataset (Large and Yeager; Clim. Dyn., 33, 2009). In our second simulation, we force our climate model using an altered version of CORE interannual forcing, based on the latter half of the full time series, which we take as a proxy for a future climate state biased towards a positive SAM. We compare ocean model states and sub-ice shelf melt rates with observations, exploring sources of model biases as well as the effects of the two forcing scenarios.

  1. The ACM Periodical Bank: A Retrospective View.

    ERIC Educational Resources Information Center

    Clarke, Jack A.

    1980-01-01

    Evaluates a cooperative venture in interlibrary lending of periodicals planned and executed by ten midwestern colleges. The study traces the consortium's history from 1967 to the present, describing successes and problems. (RAA)

  2. Proposed Expansion of Acme Landfill Operations.

    DTIC Science & Technology

    1982-08-01

    plastic beverage bottles, cardboard, wood, yardwastes, textiles , rubber, and leather. In addition to traditional activities, a central processing center...from food and garden wastes), a considerable portion of the leachate strength may be attributable to the textiles , rubber, leather, wood, paper, and...poisoning); mosquitos which may carry viral diseases such as encephalitis, malaria, and yellow fever; rodents which are carriers of enteric and other

  3. The Acme of Skill: Nonkinetic Warfare

    DTIC Science & Technology

    2008-05-01

    frontmatter.indd 6 7/29/08 12:15:43 PM Introduction The term nonkinetic warfare may seem to be an oxy- moron . How can warfare be described as...the hallmark of the previous two genera- tions of warfare. The authors attribute the evolution of warfare largely to the advancement in technology and

  4. Predicting Air Combat Maneuvering (ACM) Performance: Fleet Fighter ACM Readiness Program Grades as Performance Criteria.

    DTIC Science & Technology

    1987-10-01

    predict fleet aviator inflight performance using perceptual psychomotor and information processing tasks. The goal is to develop relevant laboratory...were useful in identifying successful and unsuccessful aviators in combat (Viet Nam). Bale at al. (2) evaluated F-4 ’Replacement Air Group (RAG...predict performance. Our approach used performance-based tests of cognitive* perceptual, and multitask functioning to predict fleet operational aviator

  5. ACM CCS 2013-2015 Student Travel Support

    DTIC Science & Technology

    2016-10-29

    comprising 82 experts from 16 countries as well as 310 external reviewers evaluated these submissions in the customary double- blind manner. At the end of...submissions employing the customary double- blind review procedure. The review process resulted in 114 papers being accepted to the program, representing...customary double- blind review procedure. The review process resulted in 128 papers being accepted to the program (with authors from 19 countries

  6. Automated Construction Management System (ACMS). Volume 2. Program Documentation.

    DTIC Science & Technology

    1984-06-01

    fe -e !t !a’.*I - . I’ q . .% % .. -S C .. .. .. .. .. .. .. . .. . 19 BAC UP CM . . oo o .. .. s.. .. .. . o.. s .. .. . . . . 197 WP . M s . . . . .s...USE RETURN * * *END BACKUP.CMD 26**. *% A C M S Ver. 84.0 ’ * USA-CERL PROGRAM: BILL.CMD " * DESCRIPTION: This program allows the user to set up ...11,0 SAY "Schedules Included: " ?? " <Type CTR-Q to abort>" SELECT SECOND STORE 12 TO row STORE 0 TO col * up to 80 schedules can be displayed on

  7. Surgical management of an ACM aneurysm eight years after coiling.

    PubMed

    Pogády, P; Fellner, F; Trenkler, J; Wurm, G

    2007-04-01

    The authors present a case report on rebleeding of a medial cerebral aneurysm (MCA) eight years after complete endovascular coiling. The primarily successfully coiled MCA aneurysm showed a local regrowth which, however, was not the source of the rebleeding. The angiogram demonstrated no evidence of contrast filling of the coiled segment, but according to intraoperative findings (haematoma location, displacement of coils, evident place of rupture) there is no doubt that the coiled segment of the aneurysm was responsible for the haemorrhage.

  8. Migraine with aura, bipolar depression, ACM aneurysm. A case report.

    PubMed

    de Filippis, Sergio; Salvatori, Emiliano; Bozzao, Alessandro; Fantozzi, Luigi Maria; Martelletti, Paolo

    2005-04-01

    B.D. is a 48-year-old professional woman. She has been suffering for migraine since she was 28, but she did not have serious problems until last year, when headache episodes became more frequent and it was necessary an admission to emergency room. At the beginning, the events were about 6 per month, lasting from 2 to 4 days, beating and of high intensity together with nausea, vomit, photo and phonophobia and visual area. Looking at the anamnesis, we report a psychiatric treatment since about ten years, because of type II bipolar disorder. In spite of the psychopharmacological treatment, as the patient came in our Regional Headache Center, she talked about 7 events with aura (scintillating scotomas, emianopsia) per month, lasting 2-4 days with photo and phonophobia, nausea, crying crisis, anxiety. Although the neurological examination was normal, the sudden aggravation of pain symptomatology and the unresposiveness to usual painkillers, suggested a cerebral CT and CT-angiography. CT and CT-angiography discovered the presence of an aneurysm of the right middle cerebral artery (MCA) of 4 mm diameter, with parietal irregularities. The patient was operated to reduce the hemorrhagic risk, with a positive result. One year after the operation, the patient reports a decrease of headache events with a frequency of 2 per month, lasting only a few hours, which she can now solve with COXIB.

  9. US EPA, Pesticide Product Label, ACME GARDEN WEED ...

    EPA Pesticide Factsheets

    2011-04-21

    ... til jI~ "f (I \\ ~) I ~ , .. i'" I' C"IIII,il'! 1'(~I'(~"t sill I 1'1' () I- Il , h. I II I ,. I 'I \\;

  10. Multilingual Information Discovery and AccesS (MIDAS): A Joint ACM DL'99/ ACM SIGIR'99 Workshop.

    ERIC Educational Resources Information Center

    Oard, Douglas; Peters, Carol; Ruiz, Miguel; Frederking, Robert; Klavans, Judith; Sheridan, Paraic

    1999-01-01

    Discusses a multidisciplinary workshop that addressed issues concerning internationally distributed information networks. Highlights include multilingual information access in media other than character-coded text; cross-language information retrieval and multilingual metadata; and evaluation of multilingual systems. (LRW)

  11. Multilingual Information Discovery and AccesS (MIDAS): A Joint ACM DL'99/ ACM SIGIR'99 Workshop.

    ERIC Educational Resources Information Center

    Oard, Douglas; Peters, Carol; Ruiz, Miguel; Frederking, Robert; Klavans, Judith; Sheridan, Paraic

    1999-01-01

    Discusses a multidisciplinary workshop that addressed issues concerning internationally distributed information networks. Highlights include multilingual information access in media other than character-coded text; cross-language information retrieval and multilingual metadata; and evaluation of multilingual systems. (LRW)

  12. ARM Airborne Carbon Measurements (ARM-ACME) and ARM-ACME 2.5 Final Campaign Reports

    SciTech Connect

    Biraud, S. C.; Tom, M. S.; Sweeney, C.

    2016-01-01

    We report on a 5-year multi-institution and multi-agency airborne study of atmospheric composition and carbon cycling at the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Southern Great Plains (SGP) site, with scientific objectives that are central to the carbon-cycle and radiative-forcing goals of the U.S. Global Change Research Program and the North American Carbon Program (NACP). The goal of these measurements is to improve understanding of 1) the carbon exchange of the Atmospheric Radiation Measurement (ARM) SGP region; 2) how CO2 and associated water and energy fluxes influence radiative-forcing, convective processes, and CO2 concentrations over the ARM SGP region, and 3) how greenhouse gases are transported on continental scales.

  13. A Search Relevance Algorithm for Weather Effects Products

    DTIC Science & Technology

    2009-10-01

    Iraq SPOT Reports MNC-I (OIF 05 - 07)SPOTREPS SIGACTS HUMINT Spot Reports - TW IM2O SPOTREPs ISM ( IIRs ) Tearline Reporting Sanitized portion...Airborne) Commercial imagery National Imagery & FINTEL MIDB Bomb Makers SIPR CENTCOM Iraq BAT CENTCOM Iraq Tactical Reports CENTCOM Iraq SIGACTS

  14. Unforgeable noise-tolerant quantum tokens

    PubMed Central

    Pastawski, Fernando; Yao, Norman Y.; Jiang, Liang; Lukin, Mikhail D.; Cirac, J. Ignacio

    2012-01-01

    The realization of devices that harness the laws of quantum mechanics represents an exciting challenge at the interface of modern technology and fundamental science. An exemplary paragon of the power of such quantum primitives is the concept of “quantum money” [Wiesner S (1983) ACM SIGACT News 15:78–88]. A dishonest holder of a quantum bank note will invariably fail in any counterfeiting attempts; indeed, under assumptions of ideal measurements and decoherence-free memories such security is guaranteed by the no-cloning theorem. In any practical situation, however, noise, decoherence, and operational imperfections abound. Thus, the development of secure “quantum money”-type primitives capable of tolerating realistic infidelities is of both practical and fundamental importance. Here, we propose a novel class of such protocols and demonstrate their tolerance to noise; moreover, we prove their rigorous security by determining tight fidelity thresholds. Our proposed protocols require only the ability to prepare, store, and measure single quantum bit memories, making their experimental realization accessible with current technologies.

  15. An Investigation of the Squadron Air Combat Training System (HAVE ACME)

    DTIC Science & Technology

    1996-06-01

    flight) ALOAD Trajectory/Maneuver Gs (Og for straight and level flight) AOA Angle of attack in degrees PITCH Elevation angle of the aircraft longitudinal axis...in degrees YAW Azimuth angle between the aircraft longitudinal axis and North in degrees ROLL Roll angle of transverse/wing axis about

  16. Proceedings of the ACM-SIGSAM 1989 international symposium on symbolic and algebraic computation

    SciTech Connect

    Not Available

    1989-01-01

    This book contain subjects under the following topics: Gencray: A portable code generator for Cray fortan; massively parallel symbolic computation; reduction of group constructions to point stabilizers; and constrained equational reasoning.

  17. Micro-Stirling Active Cooling Module (MS/ACM) for DoD Electronics Systems

    DTIC Science & Technology

    2012-03-01

    coolers the dominant type of cooler for cooling space-based electronics. In theory, the Stirling refrigeration cycle can achieve the Carnot COP (the...indicates the ideal Stirling refrigeration cycle achieves the Carnot COP, which is the theoretical maximum possible achievable COP. However...overcoming the technical challenges. Finally we describe the wide range of applications for Stirling- cycle coolers, cryocoolers, and generators

  18. Career Patterns, Employment and Earnings of Graduates of 11 ACM Colleges.

    ERIC Educational Resources Information Center

    Wishart, Patricia; Rossmann, Jack

    A study was conducted of 11 private liberal arts colleges, all members of the Associated Colleges of the Midwest, to relate the career experiences of four graduating classes to their college experiences. The study was conducted as part of the National Project 1, Better Information for Student Choice, supported by the Fund for the Improvement of…

  19. 1973 Winter Simulation Conference. Sponsored by ACM/AIIE/SHARE/SCi/TIMS.

    ERIC Educational Resources Information Center

    Hoggatt, Austin Curwood, Ed.

    A record of the current state of the art of simulation and the major part it now plays in policy formation in large organizations is provided by these conference proceedings. The 40 papers presented reveal an emphasis on the applications of simulation. In addition, the abstracts of 28 papers submitted to a more informal "paper fair" are also…

  20. Gradient-based reliability maps for ACM-based segmentation of hippocampus.

    PubMed

    Zarpalas, Dimitrios; Gkontra, Polyxeni; Daras, Petros; Maglaveras, Nicos

    2014-04-01

    Automatic segmentation of deep brain structures, such as the hippocampus (HC), in MR images has attracted considerable scientific attention due to the widespread use of MRI and to the principal role of some structures in various mental disorders. In this literature, there exists a substantial amount of work relying on deformable models incorporating prior knowledge about structures' anatomy and shape information. However, shape priors capture global shape characteristics and thus fail to model boundaries of varying properties; HC boundaries present rich, poor, and missing gradient regions. On top of that, shape prior knowledge is blended with image information in the evolution process, through global weighting of the two terms, again neglecting the spatially varying boundary properties, causing segmentation faults. An innovative method is hereby presented that aims to achieve highly accurate HC segmentation in MR images, based on the modeling of boundary properties at each anatomical location and the inclusion of appropriate image information for each of those, within an active contour model framework. Hence, blending of image information and prior knowledge is based on a local weighting map, which mixes gradient information, regional and whole brain statistical information with a multi-atlas-based spatial distribution map of the structure's labels. Experimental results on three different datasets demonstrate the efficacy and accuracy of the proposed method.

  1. Career Patterns, Employment and Earnings of Graduates of 11 ACM Colleges.

    ERIC Educational Resources Information Center

    Wishart, Patricia; Rossmann, Jack

    A study was conducted of 11 private liberal arts colleges, all members of the Associated Colleges of the Midwest, to relate the career experiences of four graduating classes to their college experiences. The study was conducted as part of the National Project 1, Better Information for Student Choice, supported by the Fund for the Improvement of…

  2. USL NASA/RECON project presentations at the 1985 ACM Computer Science Conference: Abstracts and visuals

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Chum, Frank Y.; Gallagher, Suzy; Granier, Martin; Hall, Philip P.; Moreau, Dennis R.; Triantafyllopoulos, Spiros

    1985-01-01

    This Working Paper Series entry represents the abstracts and visuals associated with presentations delivered by six USL NASA/RECON research team members at the above named conference. The presentations highlight various aspects of NASA contract activities pursued by the participants as they relate to individual research projects. The titles of the six presentations are as follows: (1) The Specification and Design of a Distributed Workstation; (2) An Innovative, Multidisciplinary Educational Program in Interactive Information Storage and Retrieval; (3) Critical Comparative Analysis of the Major Commercial IS and R Systems; (4) Design Criteria for a PC-Based Common User Interface to Remote Information Systems; (5) The Design of an Object-Oriented Graphics Interface; and (6) Knowledge-Based Information Retrieval: Techniques and Applications.

  3. Multi-walled carbon nanotubes/polymer composites in absence and presence of acrylic elastomer (ACM).

    PubMed

    Kumar, S; Rath, T; Mahaling, R N; Mukherjee, M; Khatua, B B; Das, C K

    2009-05-01

    Polyetherimide/Multiwall carbon nanotube (MWNTs) nanocomposites containing as-received and modified (COOH-MWNT) carbon nanotubes were prepared through melt process in extruder and then compression molded. Thermal properties of the composites were characterized by thermo-gravimetric analysis (TGA). Field emission scanning electron microscopy (FESEM) images showed that the MWNTs were well dispersed and formed an intimate contact with the polymer matrix without any agglomeration. However the incorporation of modified carbon nanotubes formed fascinating, highly crosslinked, and compact network structure throughout the polymer matrix. This showed the increased adhesion of PEI with modified MWNTs. Scanning electron microscopy (SEM) also showed high degree of dispersion of modified MWNTs along with broken ends. Dynamic mechanical analysis (DMA) results showed a marginal increase in storage modulus (E') and glass transition temperature (T(g)) with the addition of MWNTs. Increase in tensile strength and impact strength of composites confirmed the use the MWNTs as possible reinforcement agent. Both thermal and electrical conductivity of composites increased, but effect is more pronounced on modification due to formation of network of carbon nanotubes. Addition of acrylic elastomer to developed PEI/MWNTs (modified) nanocomposites resulted in the further increase in thermal and electrical properties due to the formation of additional bond between MWNTs and acrylic elastomers at the interface. All the results presented are well corroborated by SEM and FESEM studies.

  4. Campaign datasets for ARM Airborne Carbon Measurements (ARM-ACME-V)

    SciTech Connect

    Biraud,Sebastien; Mei,Fan; Flynn,Connor; Hubbe,John; Long,Chuck; Matthews,Alyssa; Pekour,Mikhail; Sedlacek,Arthur; Springston,Stephen; Tomlinson,Jason; Chand,Duli

    2016-03-15

    Atmospheric temperatures are warming faster in the Arctic than predicted by climate models. The impact of this warming on permafrost degradation is not well understood, but it is projected to increase carbon decomposition and greenhouse gas production (CO2 and/or CH4) by arctic ecosystems. Airborne observations of atmospheric trace gases, aerosols, and cloud properties at the North Slope of Alaska are improving our understanding of global climate, with the goal of reducing the uncertainty in global and regional climate simulations and projections.

  5. Simulator Sickness Occurrences in the 2E6 Air Combat Maneuvering Simulator (ACMS).

    DTIC Science & Technology

    1981-02-01

    to consider in eval- uating the occurrence of simulator sickness in the SAAC. The Advanced Simulator for Pilot Training ( ASPT ) located at Williams AFB...uses the sane type of visual display as the Luke AFB SAAC. During on-site discussions with ASPT personnel, experiences of trainees in the ASPT were...reported as similar to those expe- * rienced in the SAAC. Although incidence rates for the ASPT were 4, not available, a tape of one subject’s

  6. Assessing the aerosol direct and first indirect effects using ACM/GCM simulation results

    NASA Astrophysics Data System (ADS)

    Huang, H.; Gu, Y.; Xue, Y.; Lu, C. H.

    2016-12-01

    Atmospheric aerosols have been found to play an important role in global climate change but there are still large uncertainty in evaluating its role in the climate system. The aerosols generally affect global and regional climate through the scattering and the absorption of solar radiation (direct effect) and through their influences on cloud particle, number and sizes (first indirect effect). The indirect effect will further affects cloud water content, cloud top albedo and surface precipitations. In this study, we investigate the global climatic effect of aerosols using a coupled NCEP Global Forecast System (GFS) and a land surface model (SSiB2) The OPAC (Optical Properties of Aerosols and Clouds) database is used for aerosol effect. The OPAC data provides the optical properties (i.e., the extinction, scattering and absorption coefficient, single-scattering albedo, asymmetry factor and phase function) of ten types of aerosols under various relative humidity conditions for investigating the global direct and first indirect effects of dust aerosols. For indirect forcings due to liquid water, we follow the approach presented by Jiang et al (2011), in which a parameterization of cloud effective radius was calculated to describe its variance with convective strength and aerosol concentration. Since the oceans also play an important role on aerosol climatic effect, we also design a set of simulations using a coupled atmosphere/ocean model (CFS) to evaluate the sensitivity of aerosol effect with two-way atmosphere-ocean interactions.

  7. The atmospheric hydrologic cycle in the ACME v0.3 model

    NASA Astrophysics Data System (ADS)

    Terai, Christopher R.; Caldwell, Peter M.; Klein, Stephen A.; Tang, Qi; Branstetter, Marcia L.

    2017-07-01

    We examine the global water cycle characteristics in the Accelerated Climate Modeling for Energy v0.3 model (a close relative to version 5.3 of the Community Atmosphere Model) in atmosphere-only simulations spanning the years 1980-2005. We evaluate the simulations using a broad range of observational and reanalysis datasets, examine how the simulations change when the horizontal resolution is increased from 1° to 0.25° , and compare the simulations against models participating in the the Atmosphere Model Intercomparison Project of the 5th Coupled Model Intercomparison Project (CMIP5). Particular effort has been made to evaluate the model using the best available observational estimates and verifying model biases with additional datasets when differences are known to exist among the observations. Regardless of resolution, the model exhibits several biases: global-mean precipitation, evaporation, and precipitable water are too high, light precipitation occurs too frequently, and the atmospheric residence time of water is too short. Many of these biases are shared by the multi-model mean climate of models participating in CMIP5. The reasons behind regional biases in precipitation are discussed by examining how different fields, such as local evaporation and transport of water vapor, contribute to the bias. Although increasing the horizontal resolution does not drastically change the water cycle, it does lead to a few differences: an increase in global mean precipitation rate, an increase in the fraction of total precipitation that falls over land, more frequent heavy precipitation (>30 mm day^{-1} ), and a decrease in precipitable water. One of the most notable changes is the shift of precipitation produced by the convective parameterization to that produced by the large-scale microphysics parameterization. We analyze how changes in moisture and circulation with resolution contribute to this shift in the precipitation partitioning. Because changing horizontal resolution requires some re-tuning, the effect of that tuning was evaluated by performing an additional simulation at 1° but using the tunings from the 0.25° simulation. The evaluation shows that the more frequent heavy precipitation, the decrease in precipitable water, and the shift from convective to large-scale precipitation are predominantly due to resolution changes, while tuning changes have a major influence on the global mean precipitation and the land/ocean partitioning of precipitation.

  8. Device 2E6 (ACMS) Air Combat Maneuvering Simulator Instructor Console Review.

    DTIC Science & Technology

    1983-12-01

    reflects this manning concept. The use of the MOs has resulted in the technician operator providing only "on call " maintenance support except for some relief...disagreement on some usage of color. The specification calls for amber to be used for color coding of instructor input actions while the MIL STD (and Navy...aircrw station design practice) calls for its use in alerting the operator to marginal conditions, the so- called "CAUTION" - 44 - bA NAVTRAEQUIPCEN 82-M

  9. Proposed Expansion of Acme Landfill Operations, Contra Costa, County, California. Volume 1.

    DTIC Science & Technology

    1983-06-01

    for example, plastic beverage bottles, cardboard, wood, yardwastes, textiles , rubber, and leather. In addition to traditional activities, a central...a 6000-foot-long dredged channel. The 200-acre parcel is crossed with a number of drainage ditches, constructed by the Contra Costa Mosquito ...incoming flow at the high tide. It is the only point of discharge for flood water and is maintained by the Contra Costa Mosquito Abatement District

  10. Guidance on Major Modification Provisions of PSD Rules as Applied to Re-Permitting at Acme Steel Co.

    EPA Pesticide Factsheets

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  11. Three-dimensional neural differentiation of embryonic stem cells with ACM induction in microfibrous matrices in bioreactors.

    PubMed

    Liu, Ning; Ouyang, Anli; Li, Yan; Yang, Shang-Tian

    2013-01-01

    The clinical use of pluripotent stem cell (PSC)-derived neural cells requires an efficient differentiation process for mass production in a bioreactor. Toward this goal, neural differentiation of murine embryonic stem cells (ESCs) in three-dimensional (3D) polyethylene terephthalate microfibrous matrices was investigated in this study. To streamline the process and provide a platform for process integration, the neural differentiation of ESCs was induced with astrocyte-conditioned medium without the formation of embryoid bodies, starting from undifferentiated ESC aggregates expanded in a suspension bioreactor. The 3D neural differentiation was able to generate a complex neural network in the matrices. When compared to 2D differentiation, 3D differentiation in microfibrous matrices resulted in a higher percentage of nestin-positive cells (68% vs. 54%) and upregulated gene expressions of nestin, Nurr1, and tyrosine hydroxylase. High purity of neural differentiation in 3D microfibrous matrix was also demonstrated in a spinner bioreactor with 74% nestin + cells. This study demonstrated the feasibility of a scalable process based on 3D differentiation in microfibrous matrices for the production of ESC-derived neural cells.

  12. Detection of mitotic nuclei in breast histopathology images using localized ACM and Random Kitchen Sink based classifier.

    PubMed

    Beevi, K Sabeena; Nair, Madhu S; Bindu, G R

    2016-08-01

    The exact measure of mitotic nuclei is a crucial parameter in breast cancer grading and prognosis. This can be achieved by improving the mitotic detection accuracy by careful design of segmentation and classification techniques. In this paper, segmentation of nuclei from breast histopathology images are carried out by Localized Active Contour Model (LACM) utilizing bio-inspired optimization techniques in the detection stage, in order to handle diffused intensities present along object boundaries. Further, the application of a new optimal machine learning algorithm capable of classifying strong non-linear data such as Random Kitchen Sink (RKS), shows improved classification performance. The proposed method has been tested on Mitosis detection in breast cancer histological images (MITOS) dataset provided for MITOS-ATYPIA CONTEST 2014. The proposed framework achieved 95% recall, 98% precision and 96% F-score.

  13. Ambulatory circadian monitoring (ACM) based on thermometry, motor activity and body position (TAP): a comparison with polysomnography.

    PubMed

    Ortiz-Tudela, Elisabet; Martinez-Nicolas, Antonio; Albares, Javier; Segarra, Francesc; Campos, Manuel; Estivill, Eduard; Rol, Maria Angeles; Madrid, Juan Antonio

    2014-03-14

    An integrated variable based on the combination of wrist Temperature, motor Activity and body Position (TAP) was previously developed at our laboratory to evaluate the functioning of the circadian system and sleep-wake rhythm under ambulatory conditions. However, the reliability of TAP needed to be validated with polysomnography (PSG). 22 subjects suffering from sleep disorders were monitored for one night with a temperature sensor (iButton), an actimeter (HOBO) and exploratory PSG. Mean waveforms, sensitivity (SE), specificity (SP), agreement rates (AR) and comparisons between TAP and sleep stages were studied. The TAP variable was optimized for SE, SP and AR with respect to each individual variable (SE: 92%; SP: 78%; AR: 86%). These results improved upon estimates previously published for actigraphy. Furthermore, TAP values tended to decrease as sleep depth increased, reaching the lowest point at phase 3. Finally, TAP estimates for sleep latency (SL: 37±9 min), total sleep time (TST: 367±13 min), sleep efficiency (SE: 86.8±1.9%) and number of awakenings (NA>5 min: 3.3±.4) were not significantly different from those obtained with PSG (SL: 29±4 min; SE: 89.9±1.8%; NA>5 min: 2.3±.4), despite the heterogeneity of the sleep pathologies monitored. The TAP variable is a novel measurement for evaluating circadian system status and sleep-wake rhythms with a level of reliability better to that of actigraphy. Furthermore, it allows the evaluation of a patient's sleep-wake rhythm in his/her normal home environment, and at a much lower cost than PSG. Future studies in specific pathologies would verify the relevance of TAP in those conditions.

  14. ARM-ACME V: ARM Airborne Carbon Measurements V on the North Slope of Alaska Field Campaign Report

    SciTech Connect

    Biraud, Sebastien C

    2016-05-01

    Atmospheric temperatures are warming faster in the Arctic than predicted by climate models. The impact of this warming on permafrost degradation is not well understood, but it is projected to increase carbon decomposition and greenhouse gas production (CO2 and/or CH4) by arctic ecosystems. Airborne observations of atmospheric trace gases, aerosols and cloud properties in North Slopes of Alaska (NSA) are improving our understanding of global climate, with the goal of reducing the uncertainty in global and regional climate simulations and projections. From June 1 through September 15, 2015, AAF deployed the G1 research aircraft and flew over the North Slope of Alaska (38 flights, 140 science flight hours), with occasional vertical profiling over Prudhoe Bay, Oliktok point, Barrow, Atqasuk, Ivotuk, and Toolik Lake. The aircraft payload included Picarro and Los Gatos Research (LGR) analyzers for continuous measurements of CO2, CH4, H2O, and CO and N2O mixing ratios, and a 12-flask sampler for analysis of carbon cycle gases (CO2, CO, CH4, N2O, 13CO2, and trace hydrocarbon species). The aircraft payload also include measurements of aerosol properties (number size distribution, total number concentration, absorption, and scattering), cloud properties (droplet and ice size information), atmospheric thermodynamic state, and solar/infrared radiation.

  15. ARM-ACME V: ARM Airborne Carbon Measurements V on the North Slope of Alaska Science and Implementation Plan

    SciTech Connect

    Biraud, S

    2015-05-01

    Atmospheric temperatures are warming faster in the Arctic than predicted by climate models. The impact of this warming on permafrost degradation is not well understood, but it is projected to increase carbon decomposition and greenhouse gas production (CO₂ and/or CH₄) by arctic ecosystems. Airborne observations of atmospheric trace gases, aerosols, and cloud properties at the North Slope of Alaska are improving our understanding of global climate, with the goal of reducing the uncertainty in global and regional climate simulations and projections.

  16. Pathfinder Lander Rover Recharge System, and MARCO POLO Controls and ACME Regolith Feed System Controls and Integration

    NASA Technical Reports Server (NTRS)

    Tran, Sarah Diem

    2015-01-01

    This project stems from the Exploration, Research, and Technology Directorate (UB) Projects Division, and one of their main initiatives is the "Journey to Mars". Landing on the surface of Mars which is millions of miles away is an incredibly large challenge. The terrain is covered in boulders, deep canyons, volcanic mountains, and spotted with sand dunes. The robotic lander is a kind of spacecraft with multiple purposes. One purpose is to be the protective shell for the Martian rover and absorb the impact from the landing forces; another purpose is to be a place where the rovers can come back to, actively communicate with, and recharge their batteries from. Rovers have been instrumental to the Journey to Mars initiative. They have been performing key research on the terrain of the red planet, trying to unlock the mysteries of the land for over a decade. The rovers that will need charging will not all have the same kind of internal battery either. RASSOR batteries may differ from the PbAC batteries inside Red Rover's chassis. NASA has invested heavily in the exploration of the surface of Mars. A driving force behind further exploration is the need for a more efficient operation of Martian rovers. One way is to reduce the weight as much as possible to reduce power consumption given the same mission parameters. In order to reduce the mass of the rovers, power generation, communication, and sample analysis systems currently onboard Martian rovers can be moved to a stationary lander deck. Positioning these systems from the rover to the Lander deck allows a taskforce of smaller, lighter rovers to perform the same tasks currently performed by or planned for larger rovers. A major task in transferring these systems to a stationary lander deck is ensuring that power can be transferred to the rovers.

  17. ACM SIGPLAN Workshop on ML and Its Applications Held in San Francisco, California on June 20-21, 1992

    DTIC Science & Technology

    1992-06-01

    University of Copenhagen Aooession For NTIS GIZA&I • DTIC TAB [ D’ic tj •-’ :2-Cr= D 8 Unarnounced C1 Di tiicut Avall an4tor Dist Special Foreword The...Consistency-Preserving Programs in Distributed ML Clifford D . Krumvieda (Cornell University) .................................... 157 Implementing ML on...some implementations of SML [App90], the representation of the datatype defined by datatype d = A I B of t, depends on the representation of t. If the

  18. Guidance on Major Modification Provisions of PSD Rules as Applied to Re-Permitting at Acme Steel Co.

    EPA Pesticide Factsheets

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Policy and Guidance Database available at www2.epa.gov/title-v-operating-permits/title-v-operating-permit-policy-and-guidance-document-index. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  19. Sharing the Burden and Risk: An Operational Assessment of the Reserve Components in Operation Iraqi Freedom

    DTIC Science & Technology

    2016-10-01

    Department of Defense (DOD) tracks the individuals deployed in various databases, while history offices, lessons learned organizations, and numerous...analysis: Significant Activities (SIGACTs) database; Theater History of Operations Reports (THOR)/Mission Report (MISREP) Analysis Tool; mobility...databases; DMDC’s Defense Casualty Analysis System; accidental injury data from the Services; archived histories , testimonies, interviews, after action

  20. Papers Presented at the ACM SIGCSE Technical Symposium on Academic Education in Computer Science [held in Houston, Texas, November 16, 1970].

    ERIC Educational Resources Information Center

    Aiken, Robert M., Ed.

    1970-01-01

    The papers given at this symposium were selected for their description of how specific problems were tackled, and with what success, as opposed to proposals unsupported by experience. The goal was to permit the audience to profit from the trials (and errors) of others. The eighteen papers presented are: "Business and the University Computer…

  1. The Papers of the ACM SIGCSE-SIGCUE Technical Symposium, Computer Science and Education (Anaheim, California, February 12 and 13, 1976).

    ERIC Educational Resources Information Center

    Colman, Ron, Ed.; Lorton, Paul, Jr., Ed.

    1976-01-01

    Over 65 papers presented at a joint symposium sponsored by the Association for Computing Machinery's Special Interest Groups on Computer Uses in Education and on Computer Science Education are gathered here. The papers cover a wide range of topics, including structured programing, computer literacy, computer science education, computerized test…

  2. Papers Presented at the ACM SIGCSE Technical Symposium on Academic Education in Computer Science [held in Houston, Texas, November 16, 1970].

    ERIC Educational Resources Information Center

    Aiken, Robert M., Ed.

    1970-01-01

    The papers given at this symposium were selected for their description of how specific problems were tackled, and with what success, as opposed to proposals unsupported by experience. The goal was to permit the audience to profit from the trials (and errors) of others. The eighteen papers presented are: "Business and the University Computer…

  3. National Program for Inspection of Non-Federal Dams. Acme Pond Dam (CT 00172), Quinebaug River Basin, Killingly, Connecticut. Phase I Inspection Report.

    DTIC Science & Technology

    1981-03-01

    in 1872 when turbines were installed in 0 place of the " wooden breast wheels". During 1945 the 16" discharge pipe and the fire protection system were...L. Ross 1874-1899 A.G.Bishop 1899- ? United Tool Co. 1907-1910 Walter Guile 1910-1918 In 1872 the "old fashioned wooden breast wheels" were replaced

  4. Proceedings of the Annual ACM Symposium (11th) on Principles of Distributed Computing Held in Vancouver, British Columbia, Canada on 10-12 Aug 1992

    DTIC Science & Technology

    1992-08-10

    studied in two This question has been studied for a variety of prob- new timing models , the periodic and the sporadic. Both lems, including Byzantint...does not include the time that the recipient takes 2.1.2 Message Passing Model (MPM) to receive the message. That is, the time elapsed between the...tesponse. including the time ior reviewing instructionrs, searching estling data sources. gathering and maintaining the data needed, and completing and

  5. 78 FR 15014 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... and as trustee of the: ACM, Jr. 2010 3Y GRAT A, the ACM, Jr. 2010 3Y GRAT B, the ACM, Jr. 2010 3Y GRAT C, the ACM, Jr. 2013 2Y GRAT A, the ACM, Jr. 2013 2Y GRAT B, the ACM, Jr. 2013 2Y GRAT C, the ACM... GRAT B; the EMK 2013 2Y GRAT C; the EMK 2013 2Y GRAT D; the EMK 2013 2Y GRAT E; the ACM, Jr. 2010...

  6. 40 CFR Appendix A to Subpart M of... - Interpretive Rule Governing Roof Removal Operations

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-containing material (ACM) is material containing more than one percent asbestos as determined using the... NESHAP classifies ACM as either “friable” or “nonfriable”. Friable ACM is ACM that, when dry, can be crumbled, pulverized or reduced to powder by hand pressure. Nonfriable ACM is ACM that, when dry, cannot...

  7. Integrated Cognitive-neuroscience Architectures for Understanding Sensemaking (ICArUS): Phase 1 Challenge Problem Walkthrough

    DTIC Science & Technology

    2014-11-01

    Unlike Task 3, the subject is given the center (from HUMINT ) for one group, along with four possible locations 1, 2, 3, and 4 of attack by that...The subject is required to aggregate the prior ( HUMINT ) and SOCINT probabilities. The subject allocates resources in percentages (not a forced choice...trials, 4 stages per trial]. Unlike Task 4, the subject is given an attack location (SIGACT) along with group centers ( HUMINT ) for four groups (A, B

  8. 77 FR 60996 - Office of the Assistant Secretary for Health, Statement of Organization, Functions, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... to the Office of the Surgeon General (ACM). The changes are as follows: I. Under Part A, Chapter AC..., Functions, ``I. Office of Surgeon General (ACM), Section ACM.20 Functions, (c) Division of Commissioned... Section AC.20, Functions, ``I. Office of Surgeon General (ACM), Section ACM.20 Functions, (e) Division...

  9. 40 CFR 763.91 - Operations and maintenance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... thermal system insulation ACM, or friable suspected ACBM assumed to be ACM are present shall be cleaned at... damaged ACM with materials such as asbestos-free spackling, plaster, cement, or insulation, or seal...

  10. 40 CFR 61.150 - Standard for waste disposal for manufacturing, fabricating, demolition, renovation, and spraying...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... apply to Category I nonfriable ACM waste and Category II nonfriable ACM waste that did not become...) The requirements of paragraph (b) of this section do not apply to Category I nonfriable ACM that...

  11. U.S. Department of Energy, National Energy Technology Laboratory Solid-State Lighting Core Technologies Light Emitting Diodes on Semipolar Bulk GaN Substrate with IQE > 80% at 150 A/cm2 and 100 0C

    SciTech Connect

    Chakraborty, Arpan; David, Aurelien; Grundmann, Michael; Tyagi, Anurag; Craven, Michael; Hurni, Christophe; Cich, Michael

    2015-03-31

    GaN is a crucial material for light-emitting diodes (LEDs) emitting in the violet-to-green range. Despite its good performance, it still suffers from significant technical limitations. In particular, the efficiency of GaN-based LEDs decreases at high current (“current droop”) and high temperature (“temperature droop”). This is problematic in some lighting applications, where a high-power operation is required. This program studied the use of particular substrates to improve the efficiency of GaN-based LEDs: bulk semipolar (SP) GaN substrates. These substrates possess a very high material quality, and physical properties which are distinctly different from legacy substrates currently used in the LED industry. The program focused on the development of accurate metrology to quantify the performance of GaN-based LEDs, and on improvement to LED quality and design on SP substrates. Through a thorough optimization process, we demonstrated violet LEDs with very high internal quantum efficiency, exceeding 85% at high temperature and high current. We also investigated longer-wavelength blue emitters, but found that the limited strain budget was a key limitation.

  12. Proceedings of the ACM (Association for Computing Machinery, Inc.) SIGSOFT/SIGPLAN, Software Engineering Symposium on Practical Software Development Environments (2nd) Held in Palo Alto, California on 9-11 December 1986.

    DTIC Science & Technology

    new implementation schemes for interactive program design, construction, debugging and testing. Topics of interest included: monolingual and... multilingual environments, production quality environments, database support for environments, knowledge based environments, workstation based environments

  13. 75 FR 18536 - Agency Information Collection Activities: Proposed Collection, Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ... ] Management Audit and Compliance Management (ACM) and Financial Management (FM) processes, and to assure that..., transportation contracts, and service contracts, supporting our ACM responsibilities under Federal and...

  14. 40 CFR 763.90 - Response actions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... significantly damaged thermal system insulation ACM is present in a building, the local education agency shall... technological factors, to repair the damage. (3) Maintain all thermal system insulation ACM and its covering in..., thermal system insulation ACM, or friable miscellaneous ACM that has potential for damage is present in...

  15. 40 CFR 763.90 - Response actions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... significantly damaged thermal system insulation ACM is present in a building, the local education agency shall... technological factors, to repair the damage. (3) Maintain all thermal system insulation ACM and its covering in..., thermal system insulation ACM, or friable miscellaneous ACM that has potential for damage is present in...

  16. 77 FR 30005 - Office of the Assistant Secretary for Health, Statement of Organization, Functions, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ..., it realigns these functions in the Office of the Surgeon General (ACM) and abolishes the Office of....20, Functions, delete Paragraph ``I. Office of Surgeon General (ACM),'' in its entirety and replace with the following: I. Office of the Surgeon General (ACM) Section ACM.00 Mission: The Office of...

  17. 40 CFR 61.141 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... asbestos-containing material (ACM) means asbestos-containing packings, gaskets, resilient floor covering... nonfriable ACM means any material, excluding Category I nonfriable ACM, containing more than 1 percent... asbestos material, (b) Category I nonfriable ACM that has become friable, (c) Category I nonfriable...

  18. 77 FR 15145 - Ares Capital Corporation et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ...: Ares Capital Corporation (the ``Company''), Ares Capital Management LLC (``ACM'') and Ivy Hill Asset...''). The Board has delegated daily management and investment authority to ACM pursuant to an investment advisory and management agreement between ACM and the ] Company. ACM, a Delaware limited liability...

  19. Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase.

    PubMed

    Magi, Shigeyuki; Shitara, Tetsuo; Takemoto, Yasushi; Sawada, Masato; Kitagawa, Mitsuhiro; Tashiro, Etsu; Takahashi, Yoshikazu; Imoto, Masaya

    2013-03-01

    In the course of screening for an inhibitor of farnesyl transferase (FTase), we identified two compounds, N-benzyl-aclacinomycin A (ACM) and N-allyl-ACM, which are new derivatives of ACM. N-benzyl-ACM and N-allyl-ACM inhibited FTase activity with IC50 values of 0.86 and 2.93 μM, respectively. Not only ACM but also C-10 epimers of each ACM derivative failed to inhibit FTase. The inhibition of FTase by N-benzyl-ACM and N-allyl-ACM seems to be specific, because these two compounds did not inhibit geranylgeranyltransferase or geranylgeranyl pyrophosphate (GGPP) synthase up to 100 μM. In cultured A431 cells, N-benzyl-ACM and N-allyl-ACM also blocked both the membrane localization of H-Ras and activation of the H-Ras-dependent PI3K/Akt pathway. In addition, they inhibited epidermal growth factor (EGF)-induced migration of A431 cells. Thus, N-benzyl-ACM and N-allyl-ACM inhibited EGF-induced migration of A431 cells by inhibiting the farnesylation of H-Ras and subsequent H-Ras-dependent activation of the PI3K/Akt pathway.

  20. Environmental Compliance Assessment Management Program (ECAMP) - U.S. Fish and Wildlife Service (FWS)

    DTIC Science & Technology

    1994-06-01

    Propenenitrile ................................ 107-13-1 U009 Aflatoxins ................................... Same...includes friable asbestos material; Cat- egory I nonfriable ACM that has become friable; Category I nonfriable ACM that has been subjected to grinding

  1. 75 FR 9843 - National Priorities List, Proposed Rule No. 52

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ......... St. Clair Shores, MI EPA-HQ-SFUND-2010-00 69. Vienna Wells Vienna, MO EPA-HQ-SFUND-2010-00 70. ACM... Shores Drain......... St. Clair Shores MO Vienna Wells Vienna MT ACM Smelter and Refinery..........

  2. 40 CFR 763.84 - General local education agency responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... locations of ACBM and suspected ACBM assumed to be ACM. (e) Ensure that warning labels are posted in..., identification, and assessment of ACM. (iii) Options for controlling ACBM. (iv) Asbestos management programs....

  3. 40 CFR 763.87 - Analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... not to contain ACM only if the results of all samples required to be collected from the area show asbestos in amounts of 1 percent or less. (2) A homogeneous area shall be determined to contain ACM...

  4. 40 CFR 763.80 - Scope and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... education agencies to identify friable and nonfriable asbestos-containing material (ACM) in public and..., sampling such materials if they are not assumed to be ACM, and having samples analyzed by...

  5. 75 FR 22150 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... for ACM Medical Laboratory, Inc. and Advanced Toxicology Network were combined. The listings should be separated and read as follows: ACM Medical Laboratory, Inc.,160 Elmgrove Park,Rochester, NY...

  6. Elements of an Asbestos Operations and Maintenance (O&M) Program

    EPA Pesticide Factsheets

    Links to descriptions of Elements of an Operations and Maintenance (O&M) Program: Training, Occupant Notification, Monitoring ACM, Job-Site Controls for Work Involving ACM, Safe Work Practices, Recordkeeping, Worker Protection.

  7. NUDTSNA at TREC 2015 Microblog Track: A Live Retrieval System Framework for Social Network based on Semantic Expansion and Quality Model

    DTIC Science & Technology

    2015-11-20

    infor- mation extraction in knowitall:(preliminary results),” in Proceedings of the 13th international conference on World Wide Web. ACM , 2004, pp. 100...knowledge,” in Proceedings of the 2008 ACM SIGMOD international conference on Management of data. ACM , 2008, pp. 1247–1250. [7] W. Wu, H. Li, H. Wang, and...K. Q. Zhu, “Probase: A probabilistic taxonomy for text understanding,” in Proceedings of the 2012 ACM SIGMOD International Conference on Management

  8. WaterlooClarke: TREC 2015 Clinical Decision Support Track

    DTIC Science & Technology

    2015-11-20

    and S. Buettcher. Reciprocal rank fusion outperforms condorcet and individual rank learning methods. In Proceedings of the 32nd international ACM SIGIR...conference on Research and development in information retrieval, pages 758–759. ACM , 2009. Y. Lv and C. Zhai. When documents are very long, bm25 fails...In Proceedings of the 34th international ACM SIGIR conference on Research and development in Information Retrieval, pages 1103–1104. ACM , 2011. M

  9. Ultra-Scalable Algorithms for Large-Scale Uncertainty Quantification in Inverse Wave Propagation

    DTIC Science & Technology

    2016-03-04

    assumed assistant professor positions (at the University of Utah and Florida State University). At the ACM /IEEE SC’15 conference, Dhairya Malhotra...received the ACM George Michael HPC Fellowship Award for his work on the fast multipole method and Amir Gholami received the Gold Prize in the ACM Student...Conference for High Performance Computing, Networking, Storage, and Analysis, ACM /IEEE, 2003. Gordon Bell Prize for Special Achievement. [2] V. Akçelik

  10. Artificial Immune System for Flight Envelope Estimation and Protection

    DTIC Science & Technology

    2014-12-31

    Figure 1.7. AIS-Based ACM Process 31 Figure 1.8. AIS-Based ACM System Design 32 Figure 1.9. On-Line AC Detection... ACM ) based on the AIS paradigm can be considered to include three main components functionally connected in a closed loop as shown in Figure 1.7...off-line ACM system design and implementation  on-line AC detection, identification, evaluation, and accommodation  post-processing of flight data

  11. Intensional Analysis of Quantified Types

    DTIC Science & Technology

    2005-01-01

    Programming Language Design and Implementation. ACM Press, 81–91. MORRISETT, G., WALKER, D., CRARY, K., AND GLEW, N. 1998. From System F to typed assembly...SIGPLAN Conference on Programming Language Design and Implementation. ACM Press, 227–236. PFENNING, F. AND PAULIN-MOHRING, C. 1989. Inductively defined...type-based compiler for Standard ML. In Proceedings of the 1995 ACM SIGPLAN Conference on Programming Language Design and Implementation. ACM Press, 116

  12. Fully Reflexive Intensional Type Analysis

    DTIC Science & Technology

    2005-01-01

    Programming Language Design and Implementa- tion, pages 227–236. ACM Press, June 1993. [17] F. Pfenning and C. Paulin-Mohring. Inductively defined...compiler for Standard ML. In Proc. ACM SIGPLAN ’95 Conf. on Programming Language Design and Implementation, pages 116–129, New York, 1995. ACM Press...Lee. TIL: A type-directed optimizing compiler for ML. In Proc. ACM SIGPLAN ’96 Conf. on Programming Language Design and Imple- mentation, pages 181

  13. Assessment of pesticide residues in army cutworm moths (Euxoa auxiliaris) from the Greater Yellowstone Ecosystem and their potential consequences to foraging grizzly bears (Ursus arctos horribilis).

    PubMed

    Robison, Hillary L; Schwartz, Charles C; Petty, Jim D; Brussard, Peter F

    2006-09-01

    During summer, a grizzly bear (Ursus arctos horribilis) in the Greater Yellowstone Ecosystem (GYE) (USA) can excavate and consume millions of army cutworm moths (Euxoa auxiliaris) (ACMs) that aggregate in high elevation talus. Grizzly bears in the GYE were listed as threatened by the US Fish and Wildlife Service in 1975 and were proposed for delisting in 2005. However, questions remain about key bear foods. For example, ACMs are agricultural pests and concern exists about whether they contain pesticides that could be toxic to bears. Consequently, we investigated whether ACMs contain and transport pesticides to bear foraging sites and, if so, whether these levels could be toxic to bears. In 1999 we collected and analyzed ACMs from six bear foraging sites. ACMs were screened for 32 pesticides with gas chromatography with electron capture detection (GC-ECD). Because gas chromatography with tandem mass spectrometry (GC-MS/MS) can be more sensitive than GC-ECD for certain pesticides, we revisited one site in 2001 and analyzed these ACMs with GC-MS/MS. ACMs contained trace or undetectable levels of pesticides in 1999 and 2001, respectively. Based on chemical levels in ACMs and numbers of ACMs a bear can consume, we calculated the potential of chemicals to reach physiological toxicity. These calculations indicate bears do not consume physiologically toxic levels of pesticides and allay concerns they are at risk from pesticides transported by ACMs. If chemical control of ACMs changes in the future, screening new ACM samples taken from bear foraging sites may be warranted.

  14. 75 FR 26131 - National Oil and Hazardous Substance Pollution Contingency Plan; National Priorities List

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ..., grading the asbestos- containing material (ACM) to the required elevations, installation of a layer of... constructed over the ACM waste and institutional controls, is protective and will remain protective of human health and the environment. Solidification and stabilization of the ACM was incorporated into the...

  15. 48 CFR 301.607-77 - Governance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Governance. The Departmental ACM, in ASFR/OGAPA/DA, serves as the Departmental FAC-P/PM Program Manager and... certification program at the OPDIV level, Executive Officers and their HCAs may either use their existing ACM or designate an additional ACM, whose professional background includes program and project management....

  16. ECNU at TREC 2015: Microblog Track

    DTIC Science & Technology

    2015-11-20

    measuring the divergence from randomness. ACM Transactions on Information Systems (TOIS), 20(4):357–389, 2002. [2] Q. Chen, Q. Hu, Y. Pei, Y. Yang, and L. He...retrieval. In Proceedings of the 21st annual international ACM SIGIR conference on Research and development in information retrieval, pages 275–281. ACM , 1998

  17. 75 FR 27192 - National Oil and Hazardous Substances Pollution Contingency Plan; National Priorities List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ..., asbestos containing material (ACM), and slag waste identified as a characteristic hazardous waste because... concern. Also present at the Site was a UST with unknown contents, ACM, and slag waste identified as a... disposal of ACM and the UST, and the excavation, treatment, and offsite disposal of hazardous wastes....

  18. 40 CFR 763.93 - Management plans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assumed to be ACM. (2) For each inspection conducted before the December 14, 1987: (i) The date of the... material was sampled for ACM, and, if possible, the exact locations where bulk samples were collected, and... friable suspected ACBM assumed to be ACM, and the name and signature, State of accreditation, and...

  19. 40 CFR 763.90 - Response actions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... significantly damaged thermal system insulation ACM is present in a building, the local education agency shall... technological factors, to repair the damage. (3) Maintain all thermal system insulation ACM and its covering in an intact state and undamaged condition. (c)(1) If damaged friable surfacing ACM or damaged...

  20. 78 FR 2919 - Proposed Priority-National Institute on Disability and Rehabilitation Research-Disability and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... guidelines. In Proceedings of ASSETS '09 ACM SIGACCESS Conference on Computers and Accessibility. New York: ACM, 131-138. Cloud4all (n.d.). Cloud platforms lead to open and universal access for people with...: Proceedings of the Seventh Symposium On Usable Privacy and Security. New York: ACM. Erickson, T....

  1. 40 CFR 763.86 - Sampling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... samples from each homogeneous area of friable surfacing material that is not assumed to be ACM, and shall... samples from each homogeneous area of thermal system insulation that is not assumed to be ACM. (2) Collect... assumed to be ACM if the patched section is less than 6 linear or square feet. (3) In a manner...

  2. A NEW COMBINED LOCAL AND NON-LOCAL PBL MODEL FOR METEOROLOGY AND AIR QUALITY MODELING

    EPA Science Inventory

    A new version of the Asymmetric Convective Model (ACM) has been developed to describe sub-grid vertical turbulent transport in both meteorology models and air quality models. The new version (ACM2) combines the non-local convective mixing of the original ACM with local eddy diff...

  3. 75 FR 62008 - Safety Management System for Certificated Airports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... differences between their FAA-approved Airport Certification Manual (ACM), part 139 requirements, and a..., a certificate holder may maintain a separate SMS Manual in addition to the ACM or may maintain SMS documentation directly in the ACM. If a certificate holder develops a separate manual, it would...

  4. 40 CFR 61.145 - Standard for demolition and renovation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... presence of asbestos, including Category I and Category II nonfriable ACM. The requirements of paragraphs... and Category I and Category II nonfriable ACM. (vi) Estimate of the approximate amount of RACM to be... nonfriable ACM in the affected part of the facility that will not be removed before demolition....

  5. 76 FR 5510 - Safety Enhancements Part 139, Certification of Airports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-01

    ... operations below 1,200 feet RVR to implement a SMGCS plan in its airport certification manual (ACM). Fourth... certificate holder's ACM. A person would complete this training prior to accessing the non- movement area, and..., procedures for operating in the non-movement area, and duties required by the ACM or regulations. Although...

  6. 40 CFR 763.94 - Recordkeeping.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... be ACM, the local education agency shall provide: (1) A detailed written description of the measure... is removed, the name and location of storage or disposal site of the ACM. (2) The name and signature... of storage or disposal site of the ACM. (g) For each time that major asbestos activity under §...

  7. 40 CFR 763.99 - Exclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... is assumed to be ACM. The inspector shall sign and date a statement to that effect, with his or her... ACBM assumed to be ACM has become friable since the previous inspection and shall assess the newly friable material and previously identified friable suspected ACBM assumed to be ACM under § 763.88....

  8. 40 CFR 763.85 - Inspection and reinspections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... some or all of the homogeneous areas are ACM, and, for each homogeneous area that is not assumed to be ACM, collect and submit for analysis bulk samples under §§ 763.86 and 763.87. (v) Assess, under § 763... friable suspected ACBM is assumed to be ACM, and homogeneous areas where nonfriable suspected ACBM...

  9. A NEW COMBINED LOCAL AND NON-LOCAL PBL MODEL FOR METEOROLOGY AND AIR QUALITY MODELING

    EPA Science Inventory

    A new version of the Asymmetric Convective Model (ACM) has been developed to describe sub-grid vertical turbulent transport in both meteorology models and air quality models. The new version (ACM2) combines the non-local convective mixing of the original ACM with local eddy diff...

  10. Principled Scavenging

    DTIC Science & Technology

    2000-11-01

    5] K. Crary and S. Weirich . Flexible type analysis. In Proc. 1999 ACM SIGPLAN International Conference on Functional Programming, pages 233–248. ACM...Press, Sept. 1999. [6] K. Crary, S. Weirich , and G. Morrisett. Intensional polymorphism in type-erasure semantics. In Proc. 1998 ACM SIGPLAN

  11. Joint Labeling Of Multiple Regions of Interest (Rois) By Enhanced Auto Context Models.

    PubMed

    Kim, Minjeong; Wu, Guorong; Guo, Yanrong; Shen, Dinggang

    2015-04-01

    Accurate segmentation of a set of regions of interest (ROIs) in the brain images is a key step in many neuroscience studies. Due to the complexity of image patterns, many learning-based segmentation methods have been proposed, including auto context model (ACM) that can capture high-level contextual information for guiding segmentation. However, since current ACM can only handle one ROI at a time, neighboring ROIs have to be labeled separately with different ACMs that are trained independently without communicating each other. To address this, we enhance the current single-ROI learning ACM to multi-ROI learning ACM for joint labeling of multiple neighboring ROIs (called eACM). First, we extend current independently-trained single-ROI ACMs to a set of jointly-trained cross-ROI ACMs, by simultaneous training of ACMs for all spatially-connected ROIs to let them to share their respective intermediate outputs for coordinated labeling of each image point. Then, the context features in each ACM can capture the cross-ROI dependence information from the outputs of other ACMs that are designed for neighboring ROIs. Second, we upgrade the output labeling map of each ACM with the multi-scale representation, thus both local and global context information can be effectively used to increase the robustness in characterizing geometric relationship among neighboring ROIs. Third, we integrate ACM into a multi-atlases segmentation paradigm, for encompassing high variations among subjects. Experiments on LONI LPBA40 dataset show much better performance by our eACM, compared to the conventional ACM.

  12. Self-assembled albumin nanoparticles as a nanocarrier for aclacinomycin A

    NASA Astrophysics Data System (ADS)

    Gong, Guangming; Liu, Wenya; Wang, Shudong

    2016-11-01

    This study aimed to reduce the cytotoxicity and improve the targeting of aclacinomycin (ACM) by covalently coupling it with amino-oxyacetic acid (AOA) to generate an active intermediate, AOA-ACM. AOA-ACM was conjugated with self-assembled human serum albumin (HSA) nanoparticles constructed using tris(2-carboxyethyl)phosphine (TCEP) as disulfide bond breaking molecules in an ‘opening stage-intermediate-closing stage’ route, in which the hydrophobic interaction, interchange of sulfhydryl and hydrogen bond may be the key factors in the assembling process. Conjugation between ACM and albumin nanoparticles was found to occur at an ACM ketone site using 1H-NMR and 13C-NMR matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass analysis indicated that the drug loading efficiency of ACM conjugated with HSA nanoparticles (NPs-ACM) was 7.4% (molar ratio = 6:1). The release of NPs-ACM was pH dependent. In vivo studies indicated that NPs-ACM exhibited fourfold higher tumor targeting capability on S180-tumor-bearing mice compared with the free ACM (p < 0.05). The cytotoxictiy and cardiotoxicity of NPs-ACM was reduced compared with the free ACM. Albumin carrier altered the blood pharmacokinetics and distribution of ACM. Hence, the NPs-ACM prodrug is ideal tumor targeting drug carriers for ACM, and the easy approach developed in this study for active intermediate and prodrug preparation can be applied to other pharmacological substances containing ketone groups. The method of preparing HSA-blank nanoparticles through TCEP reduction could be adopted to improve the water solubility of lipophilic drugs and their tumor-targeting specificity by fabricating HSA-lipophilic drug nanoparticles.

  13. Self-assembled albumin nanoparticles as a nanocarrier for aclacinomycin A.

    PubMed

    Gong, Guangming; Liu, Wenya; Wang, Shudong

    2016-11-18

    This study aimed to reduce the cytotoxicity and improve the targeting of aclacinomycin (ACM) by covalently coupling it with amino-oxyacetic acid (AOA) to generate an active intermediate, AOA-ACM. AOA-ACM was conjugated with self-assembled human serum albumin (HSA) nanoparticles constructed using tris(2-carboxyethyl)phosphine (TCEP) as disulfide bond breaking molecules in an 'opening stage-intermediate-closing stage' route, in which the hydrophobic interaction, interchange of sulfhydryl and hydrogen bond may be the key factors in the assembling process. Conjugation between ACM and albumin nanoparticles was found to occur at an ACM ketone site using (1)H-NMR and (13)C-NMR matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass analysis indicated that the drug loading efficiency of ACM conjugated with HSA nanoparticles (NPs-ACM) was 7.4% (molar ratio = 6:1). The release of NPs-ACM was pH dependent. In vivo studies indicated that NPs-ACM exhibited fourfold higher tumor targeting capability on S180-tumor-bearing mice compared with the free ACM (p < 0.05). The cytotoxictiy and cardiotoxicity of NPs-ACM was reduced compared with the free ACM. Albumin carrier altered the blood pharmacokinetics and distribution of ACM. Hence, the NPs-ACM prodrug is ideal tumor targeting drug carriers for ACM, and the easy approach developed in this study for active intermediate and prodrug preparation can be applied to other pharmacological substances containing ketone groups. The method of preparing HSA-blank nanoparticles through TCEP reduction could be adopted to improve the water solubility of lipophilic drugs and their tumor-targeting specificity by fabricating HSA-lipophilic drug nanoparticles.

  14. Asbestos-containing materials and airborne asbestos levels in industrial buildings in Korea.

    PubMed

    Choi, Sangjun; Suk, Mee-Hee; Paik, Nam Won

    2010-03-01

    Recently in Korea, the treatment of asbestos-containing materials (ACM) in building has emerged as one of the most important environmental health issues. This study was conducted to identify the distribution and characteristics of ACM and airborne asbestos concentrations in industrial buildings in Korea. A total of 1285 presumed asbestos-containing material (PACM) samples were collected from 80 workplaces across the nation, and 40% of the PACMs contained more than 1% of asbestos. Overall, 94% of the surveyed workplaces contained ACM. The distribution of ACM did not show a significant difference by region, employment size, or industry. The total ACM area in the buildings surveyed was 436,710 m2. Ceiling tile ACM accounted for 61% (267,093 m2) of the total ACM area, followed by roof ACM (32%), surfacing ACM (6.1%), and thermal system insulation (TSI). In terms of asbestos type, 98% of total ACM was chrysotile, while crocidolite was not detected. A comparison of building material types showed that the material with the highest priority for regular management is ceiling tile, followed by roof, TSI, and surfacing material. The average airborne concentration of asbestos sampled without disturbing in-place ACM was 0.0028 fibers/cc by PCM, with all measurements below the standard of recommendation for indoor air quality in Korea (0.01 fibers/cc).

  15. Acemetacin cocrystals and salts: structure solution from powder X-ray data and form selection of the piperazine salt.

    PubMed

    Sanphui, Palash; Bolla, Geetha; Nangia, Ashwini; Chernyshev, Vladimir

    2014-03-01

    Acemetacin (ACM) is a non-steroidal anti-inflammatory drug (NSAID), which causes reduced gastric damage compared with indomethacin. However, acemetacin has a tendency to form a less soluble hydrate in the aqueous medium. We noted difficulties in the preparation of cocrystals and salts of acemetacin by mechanochemical methods, because this drug tends to form a hydrate during any kind of solution-based processing. With the objective to discover a solid form of acemetacin that is stable in the aqueous medium, binary adducts were prepared by the melt method to avoid hydration. The coformers/salt formers reported are pyridine carboxamides [nicotinamide (NAM), isonicotinamide (INA), and picolinamide (PAM)], caprolactam (CPR), p-aminobenzoic acid (PABA), and piperazine (PPZ). The structures of an ACM-INA cocrystal and a binary adduct ACM-PABA were solved using single-crystal X-ray diffraction. Other ACM cocrystals, ACM-PAM and ACM-CPR, and the piperazine salt ACM-PPZ were solved from high-resolution powder X-ray diffraction data. The ACM-INA cocrystal is sustained by the acid⋯pyridine heterosynthon and N-H⋯O catemer hydrogen bonds involving the amide group. The acid⋯amide heterosynthon is present in the ACM-PAM cocrystal, while ACM-CPR contains carboxamide dimers of caprolactam along with acid-carbonyl (ACM) hydrogen bonds. The cocrystals ACM-INA, ACM-PAM and ACM-CPR are three-dimensional isostructural. The carboxyl⋯carboxyl synthon in ACM-PABA posed difficulty in assigning the position of the H atom, which may indicate proton disorder. In terms of stability, the salts were found to be relatively stable in pH 7 buffer medium over 24 h, but the cocrystals dissociated to give ACM hydrate during the same time period. The ACM-PPZ salt and ACM-nicotinamide cocrystal dissolve five times faster than the stable hydrate form, whereas the ACM-PABA adduct has 2.5 times faster dissolution rate. The pharmaceutically acceptable piperazine salt of acemetacin exhibits superior

  16. Antrodia cinnamomea profoundly exalted the reversion of activated hepatic stellate cells by the alteration of cellular proteins.

    PubMed

    Chen, Yi-Ren; Chang, Kai-Ting; Tsai, May-Jywan; Lee, Chia-Hung; Huang, Kao-Jean; Cheng, Henrich; Ho, Yen-Peng; Chen, Jian-Chyi; Yang, Hsueh-Hui; Weng, Ching-Feng

    2014-07-01

    The direct modulation of Antrodia cinnamomea (AC) on the prominent role of liver fibrosis-hepatic stellate cells (HSCs) in situ remains unclear. Firstly, the administration of A. cinnamomea mycelial extract (ACME) could improve liver morphology and histological changes including collagen formation and GPT activity in the liver of thioacetamide (TAA)-injured rats. The morphology and fatty acid restore of TAA-induced HSCs (THSCs) returned to the non-chemical induced HSCs (NHSCs) type as measured by immunofluorescence and Oil Red O staining. PPARγ was upregulated associated with the lowering of α-SMA protein in NHSC-ACME. ACME inhibited the MMP-2 activity in NHSCs by gelatin Zymography. After LC-MS/MS, the cytoskeleton (tubulin, lamin A) and heat shock protein 8 in NHSC-ACME, and guanylate kinase, brain-specific kinase, SG-II and p55 proteins were downregulated in THSC-ACME. Whereas MHC class II, SMC6 protein, and phospholipase D were upregulated in NHSC-ACME. Furthermore, PKG-1 was downregulated in NHSC-ACME and upregulated in THSC-ACME. SG-II and p55 proteins were downregulated in NHSC-ACME and THSC-ACME by Western blotting. Taken together, the beneficial effect of A. cinnamomea on the induction of HSC cellular proteins is potentially applied as an alternative and complementary medicine for the prevention and amelioration of a liver injury.

  17. Anatomical connectivity mapping: a new tool to assess brain disconnection in Alzheimer's disease.

    PubMed

    Bozzali, Marco; Parker, Geoffrey J M; Serra, Laura; Embleton, Karl; Gili, Tommaso; Perri, Roberta; Caltagirone, Carlo; Cercignani, Mara

    2011-02-01

    Previous studies suggest that the clinical manifestations of Alzheimer's disease (AD) are not only associated with regional gray matter damage but also with abnormal functional integration of different brain regions by disconnection mechanisms. A measure of anatomical connectivity (anatomical connectivity mapping or ACM) can be obtained by initiating diffusion tractography streamlines from all parenchymal voxels and then counting the number of streamlines passing through each voxel of the brain. In order to assess the potential of this parameter for the study of disconnection in AD, we computed it in a group of patients with AD (N=9), in 16 patients with amnestic mild cognitive impairment (a-MCI, which is considered the prodromal stage of AD) and in 12 healthy volunteers. All subjects had an MRI scan at 3T, and diffusion MRI data were analyzed to obtain fractional anisotropy (FA) and ACM. Two types of ACM maps, absolute count (ac-ACM) and normalized by brain size count (nc-ACM), were obtained. No between group differences in FA surviving correction for multiple comparison were found, while areas of both decreased (in the supramarginal gyrus) and increased (in the putamen) ACM were found in patients with AD. Similar results were obtained with ac-ACM and nc-ACM. ACM of the supramarginal gyrus was strongly associated with measures of short-term memory in healthy subjects. This study shows that ACM provides information that is complementary to that offered by FA and appears to be more sensitive than FA to brain changes in patients with AD. The increased ACM in the putamen was unexpected. Given the nature of ACM, an increase of this parameter may reflect a change in any of the areas connected to it. One intriguing possibility is that this increase of ACM in AD patients might reflect processes of brain plasticity driven by cholinesterase inhibitors.

  18. Cardiac mesenchymal stromal cells are a source of adipocytes in arrhythmogenic cardiomyopathy

    PubMed Central

    Sommariva, E.; Brambilla, S.; Carbucicchio, C.; Gambini, E.; Meraviglia, V.; Dello Russo, A.; Farina, F.M.; Casella, M.; Catto, V.; Pontone, G.; Chiesa, M.; Stadiotti, I.; Cogliati, E.; Paolin, A.; Ouali Alami, N.; Preziuso, C.; d'Amati, G.; Colombo, G.I.; Rossini, A.; Capogrossi, M.C.; Tondo, C.; Pompilio, G.

    2016-01-01

    Aim Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder mainly due to mutations in desmosomal genes, characterized by progressive fibro-adipose replacement of the myocardium, arrhythmias, and sudden death. It is still unclear which cell type is responsible for fibro-adipose substitution and which molecular mechanisms lead to this structural change. Cardiac mesenchymal stromal cells (C-MSC) are the most abundant cells in the heart, with propensity to differentiate into several cell types, including adipocytes, and their role in ACM is unknown. The aim of the present study was to investigate whether C-MSC contributed to excess adipocytes in patients with ACM. Methods and results We found that, in ACM patients' explanted heart sections, cells actively differentiating into adipocytes are of mesenchymal origin. Therefore, we isolated C-MSC from endomyocardial biopsies of ACM and from not affected by arrhythmogenic cardiomyopathy (NON-ACM) (control) patients. We found that both ACM and control C-MSC express desmosomal genes, with ACM C-MSC showing lower expression of plakophilin (PKP2) protein vs. controls. Arrhythmogenic cardiomyopathy C-MSC cultured in adipogenic medium accumulated more lipid droplets than controls. Accordingly, the expression of adipogenic genes was higher in ACM vs. NON-ACM C-MSC, while expression of cell cycle and anti-adipogenic genes was lower. Both lipid accumulation and transcription reprogramming were dependent on PKP2 deficiency. Conclusions Cardiac mesenchymal stromal cells contribute to the adipogenic substitution observed in ACM patients' hearts. Moreover, C-MSC from ACM patients recapitulate the features of ACM adipogenesis, representing a novel, scalable, patient-specific in vitro tool for future mechanistic studies. PMID:26590176

  19. Novel active contour model based on multi-variate local Gaussian distribution for local segmentation of MR brain images

    NASA Astrophysics Data System (ADS)

    Zheng, Qiang; Li, Honglun; Fan, Baode; Wu, Shuanhu; Xu, Jindong

    2017-09-01

    Active contour model (ACM) has been one of the most widely utilized methods in magnetic resonance (MR) brain image segmentation because of its ability of capturing topology changes. However, most of the existing ACMs only consider single-slice information in MR brain image data, i.e., the information used in ACMs based segmentation method is extracted only from one slice of MR brain image, which cannot take full advantage of the adjacent slice images' information, and cannot satisfy the local segmentation of MR brain images. In this paper, a novel ACM is proposed to solve the problem discussed above, which is based on multi-variate local Gaussian distribution and combines the adjacent slice images' information in MR brain image data to satisfy segmentation. The segmentation is finally achieved through maximizing the likelihood estimation. Experiments demonstrate the advantages of the proposed ACM over the single-slice ACM in local segmentation of MR brain image series.

  20. The potential value of three-dimensional accelerometry for detection of motor seizures in severe epilepsy.

    PubMed

    Nijsen, Tamara M E; Arends, Johan B A M; Griep, Paul A M; Cluitmans, Pierre J M

    2005-08-01

    Seizure detection results based on the visual analysis of three-dimensional (3D) accelerometry (ACM) and video/EEG recordings are reported for 18 patients with severe epilepsy. They were monitored for 36 hours during which 897 seizures were detected. This was seven times higher than the number of seizures reported by nurses during the registration period. The results in this article demonstrate that 3D ACM is a valuable sensing method for seizure detection in this population. Four hundred twenty-eight (48%) seizures were detected by ACM. With 3D ACM alone it was possible to detect all the seizures in 10 of the 18 patients. Three-dimensional ACM also was complementary to EEG in our population. ACM patterns during seizures were stereotypical in 95% of the motor seizures. These characteristic patterns are a starting point for automated seizure detection.

  1. Physical and electrochemical properties of supercapacitor composite electrodes prepared from biomass carbon and carbon from green petroleum coke

    NASA Astrophysics Data System (ADS)

    Awitdrus, Deraman, M.; Talib, I. A.; Farma, R.; Omar, R.; Ishak, M. M.; Taer, E.; Dolah, B. N. M.; Basri, N. H.; Nor, N. S. M.

    2015-04-01

    The green monoliths (GMs) were prepared from the mixtures of pre-carbonized fibers of oil palm empty fruit bunches (or self-adhesive carbon grains (SACG)) and green petroleum coke (GPC) with the mixing ratio of 0, 10, 30, 50 and 70 % GPC, respectively. The GMs were carbonized in N2 environment at 800°C to produce carbon monoliths (CM00, CM10, CM30, CM50 and CM70). The CMs were CO2 activated at 800°C for 1 hour to produced activated carbon monolith electrodes (ACM00, ACM10, ACM30, ACM50 and ACM70). For each percentage of GPC, three duplicate symmetrical supercapacitor cells were fabricated using these activated carbon monolith electrodes respectively, and the capacitive performance amongst the cells was compared and analyzed in order to observe the relationship between the capacitive performance and the physical properties (microstructure and porosity) of the ACMs electrodes containing varying percentage of GPC.

  2. Immunological cross-reactivities of various anthracycline antibiotics against aclacinomycin A antisera.

    PubMed

    Matsuzawa, Y; Kiyosaki, T; Yoshimoto, A; Ishikura, T; Takeuchi, T; Umezawa, H

    1982-11-01

    Aclacinomycin A (ACM) antisera were obtained from the rabbits immunized with 4"'-deoxo-4"'-(R)-amino-ACM- or N,N-didemethyl-ACM-bovine serum albumin conjugate, and their immunoreactivities were tested with ACM-related anthracyclines. It was found that the binding ability with the ACM antisera was markedly decreased by the following structural changes in ACM: N,N-didemethylation of the rhodosamine moiety; 6-O- or 4-O-methylation; removal of the methoxycarbonyl group at C-10; hydroxylation at C-1, C-2 or C-11. It was less affected by some alterations in a side chain at C-9 or by deglycosidation of the terminal mono or disaccharide. The binding of the aglycone (aklavinone) was very weak.

  3. Kevlar: Transitioning Helix for Research to Practice

    DTIC Science & Technology

    2016-03-01

    Giles, and Rajeev Barua. A compiler-level intermediate representation based binary analysis and rewriting system. In Proceedings of the 8th ACM ...European Conference on Computer Systems, EuroSys ’13, pages 295–308, New York, NY, USA, 2013. ACM . 3. Derek Bruening, Timothy Garnett, and Saman...K. Rosen, Mark N. Wegman, and F. Kenneth Zadeck. Efficiently computing static single assignment form and the control dependence graph. ACM

  4. Growth and acid production of Lactobacillus delbrueckii ssp. bulgaricus ATCC 11842 in the fermentation of algal carcass.

    PubMed

    Li, C; Zhang, G F; Mao, X; Wang, J Y; Duan, C Y; Wang, Z J; Liu, L B

    2016-06-01

    Algal carcass is a low-value byproduct of algae after its conversion to biodiesel. Dried algal carcass is rich in protein, carbohydrate, and multiple amino acids, and it is typically well suited for growth and acid production of lactic acid bacteria. In this study, Lactobacillus delbrueckii ssp. bulgaricus ATCC 11842 was used to ferment different algal carcass media (ACM), including 2% ACM, 2% ACM with 1.9% glucose (ACM-G), and 2% ACM with 1.9% glucose and 2g/L amino acid mixture (ACM-GA). Concentrations of organic acids (lactic acid and acetic acid), acetyl-CoA, and ATP were analyzed by HPLC, and activities of lactate dehydrogenase (LDH), acetokinase (ACK), pyruvate kinase (PK), and phosphofructokinase (PFK) were determined by using a chemical approach. The growth of L. bulgaricus cells in ACM-GA was close to that in the control medium (de Man, Rogosa, and Sharpe). Lactic acid and acetic acid contents were greatly reduced when L. bulgaricus cells were grown in ACM compared with the control medium. Acetyl-CoA content varied with organic acid content and was increased in cells grown in different ACM compared with the control medium. The ATP content of L. bulgaricus cells in ACM was reduced compared with that of cells grown in the control medium. Activities of PFK and ACK of L. bulgaricus cells grown in ACM were higher and those of PK and LDH were lower compared with the control. Thus, ACM rich in nutrients may serve as an excellent substrate for growth by lactic acid bacteria, and addition of appropriate amounts of glucose and amino acids can improve growth and acid production.

  5. BJUT at TREC 2015 Microblog Track: Real Time Filtering Using Knowledge Base

    DTIC Science & Technology

    2015-11-20

    information retrieval, volume 463. ACM press New York, 1999. Yajuan Duan, Long Jiang, Tao Qin, Ming Zhou, and Heung- Yeung Shum. An empirical study on...Linguistics, 2010. Thorsten Joachims. Optimizing search engines using clickthrough data. In Proceedings of the eighth ACM SIGKDD international...conference on Knowledge discovery and data mining, pages 133–142. ACM , 2002. ChengXiang Zhai and John Lafferty. Two-stage language models for information

  6. PREDICT: Privacy and Security Enhancing Dynamic Information Monitoring

    DTIC Science & Technology

    2015-08-03

    Advances in Geographic Information Systems ( ACM SIGSPATIAL), 2015. [4] Xiaofeng Xu, Li Xiong, Vaidy Sunderam, Jinfei Liu, Jun Lo. VPIndexer: Velocity...based Partitioning for Indexing Moving Objects (Demo), Submitted, 23rd Intl. Conf. on Advances in Geographic Information Systems ( ACM SIGSPATIAL...under Temporal Correlations. To appear, 22nd ACM Conference on Computer and Communications Security (CCS), 2015 [8] Jinfei Liu, Li Xiong, Jian Pei

  7. Utility of adaptive control processing for the interpretation of digital mammograms.

    PubMed

    Jinnouchi, Mikako; Yabuuchi, Hidetake; Kubo, Makoto; Tokunaga, Eriko; Yamamoto, Hidetaka; Honda, Hiroshi

    2016-11-01

    Background Adaptive control processing for mammography (ACM) is a novel program that automatically sets up appropriate image-processing parameters for individual mammograms (MMGs) by analyzing the focal and whole breast histogram. Purpose To investigate whether ACM improves the image contrast of digital MMGs and whether it improves radiologists' diagnostic performance in reading of MMGs. Material and Methods One hundred normal cases for image quality assessment and another 100 cases (50 normal and 50 cancers) for observer performance assessment were enrolled. All mammograms were examined with and without ACM. Five radiologists assessed the intra- and extra-mammary contrast of 100 normal MMGs, and the mean scores of the intra- and extra-mammary contrast were compared between MMGs with and without ACM in both the dense and non-dense group. They classified 100 MMGs into BI-RADS categories 1-5, and were asked to rate the images on a scale of 0 to 100 for the likelihood of the presence of category 3-5 lesions in each breast. Detectability of breast cancer, reading time, and frequency of window adjustment were compared between MMGs with and without ACM. Results ACM improved the intra-mammary contrast in both the dense and non-dense group but degraded extra-mammary contrast in the dense group. There was no significant difference in detectability of breast cancer between MMGs with and without ACM. Frequency of window adjustment without ACM was significantly higher than that with ACM. Reading time without ACM was significantly longer than that with ACM. Conclusion ACM improves the image contrast of MMGs and shortens reading time.

  8. Interactive Computational Algorithms for Acoustic Simulation in Complex Environments

    DTIC Science & Technology

    2015-07-19

    an equivalent source formulation, ACM Transactions on Graphics, (04 2013): 0. doi: 10.1145/2451236.2451245 Ravish Mehra, Nikunj Raghuvanshi, Lauri...TVCG.2013.27 Zhimin Ren, Hengchin Yeh, Ming C. Lin. Example-guided physically based modal sound synthesis, ACM Transactions on Graphics, (01 2013): 0...transfer operators, ACM Transactions on Graphics, (01 2012): 0. doi: 10.1145/2077341.2077348 Min Tang, Dinesh Manocha, Sung-Eui Yoon, Peng Du, Jae-Pil

  9. LAMDA at TREC CDS track 2015: Clinical Decision Support Track

    DTIC Science & Technology

    2015-11-20

    international ACM SIGIR conference on Research and development in information retrieval, 1998, pp. 2-1 [6] A. R. Aronson and F.-M. Lang, "An overview of...retrieval based on measuring the divergence from randomness," ACM Transactions on Information Systems (TOIS), vol. 20, pp. 357-389, 2002. [10] J. I...34 [11] J. A. Aslam and M. Montague, "Models for metasearch," in Proceedings of the 24th annual international ACM SIGIR conference on Research and

  10. Implicit-shifted Symmetric QR Singular Value Decomposition of 3x3 Matrices

    DTIC Science & Technology

    2016-04-01

    vega. BOUAZIZ, S., MARTIN, S., LIU, T., KAVAN, L., AND PAULY, M. 2014. Projective dynamics: Fusing constraint projections for fast simulation. ACM ...SCHROEDER, C., AND TERAN, J. M. 2013. A level set method for ductile fracture. In Proc ACM SIGGRAPH/Eurograp Symp Comp Anim, 193–201. IRVING, G., TERAN...J., AND FEDKIW, R. 2004. Invertible finite elements for robust simulation of large deformation. In Proc ACM SIGGRAPH/Eurograph Symp Comp Anim, 131

  11. How Effective is Routing for Wireless Networking

    DTIC Science & Technology

    2016-03-05

    world examples of multi-hop wireless networks . Today, almost all of our wireless devices communicate directly with a base station (such as WiFi or...level measurements from an 802.11 b mesh network ,” in ACM SIGCOMM Computer Communication Review, vol. 34, no. 4. ACM, 2004, pp. 121–132. [34] D. LaI...multi-hop wireless networks ,” ACM SIGCOMM Computer Communication Review, vol. 34, no. 1, pp. 69–74, 2004.

  12. Assessment of pesticide residues in army cutworm moths (Euxoa auxiliaris) from the Greater Yellowstone Ecosystem and their potential consequences to foraging grizzly bears (Ursus arctos horribilis)

    USGS Publications Warehouse

    Robison, H.L.; Schwartz, C.C.; Petty, J.D.; Brussard, P.F.

    2006-01-01

    During summer, a grizzly bear (Ursus arctos horribilis) in the Greater Yellowstone Ecosystem (GYE) (USA) can excavate and consume millions of army cutworm moths (Euxoa auxiliaris) (ACMs) that aggregate in high elevation talus. Grizzly bears in the GYE were listed as threatened by the US Fish and Wildlife Service in 1975 and were proposed for delisting in 2005. However, questions remain about key bear foods. For example, ACMs are agricultural pests and concern exists about whether they contain pesticides that could be toxic to bears. Consequently, we investigated whether ACMs contain and transport pesticides to bear foraging sites and, if so, whether these levels could be toxic to bears. In 1999 we collected and analyzed ACMs from six bear foraging sites. ACMs were screened for 32 pesticides with gas chromatography with electron capture detection (GC-ECD). Because gas chromatography with tandem mass spectrometry (GC-MS/MS) can be more sensitive than GC-ECD for certain pesticides, we revisited one site in 2001 and analyzed these ACMs with GC-MS/MS. ACMs contained trace or undetectable levels of pesticides in 1999 and 2001, respectively. Based on chemical levels in ACMs and numbers of ACMs a bear can consume, we calculated the potential of chemicals to reach physiological toxicity. These calculations indicate bears do not consume physiologically toxic levels of pesticides and allay concerns they are at risk from pesticides transported by ACMs. If chemical control of ACMs changes in the future, screening new ACM samples taken from bear foraging sites may be warranted. ?? 2006 Elsevier Ltd. All rights reserved.

  13. Evolution of an Operating System for Large-Scale Shared-Memory Multiprocessors

    DTIC Science & Technology

    1989-03-01

    ACM Operat- ing Systems Review 19:5. [7] Crowl, L. A., "Shared Memory Multiprocessors and Sequential Programming Languages: A Case Study," Proceedings...Principles, 14-16 December 1981, pp. 64-75. In ACM Operating Systems Review 15:5. [20] Redell, D., "Experience with Topaz TeleDebugging," Proceedings, ACM...34The Interface Between Distributed Operating System and High-Level Programming Language," Proceedings of the 1986 International Conference on Parallel

  14. Fully Reflexive Intensional Type Analysis in Type Erasure Semantics

    DTIC Science & Technology

    2005-01-01

    and tags, and defining an interpre- tation function to map between the two, is related to the ideas proposed by Crary and Weirich for the language LX...Science, 1995. 11 [2] K. Crary and S. Weirich . Flexible type analysis. In Proc. 1999 ACM SIGPLAN International Conference on Functional Programming, pages...233–248. ACM Press, Sept. 1999. [3] K. Crary, S. Weirich , and G. Morrisett. Intensional polymorphism in type-erasure semantics. In Proc. 1998 ACM

  15. Compiling with Types

    DTIC Science & Technology

    1995-12-01

    Space-ecient conservative garbage collection. In ACM SIGPLAN Con- ference on Programming Language Design and Implementation, pages 197{206, Albu...language. In ACM SIGPLAN Conference on Programming Language Design and Implementation, pages 273{282, San Francisco, June 1992. [36] A. Diwan, D...42] C. Flanagan, A. Sabry, B. F. Duba, and M. Felleisen . The essence of compiling with continuations. In ACM SIGPLAN Conference on Programming

  16. Evaluation of rotor-bearing system dynamic response to unbalance. [air conditioning equipment

    NASA Technical Reports Server (NTRS)

    Thaller, R. E.; Ozimek, D. W.

    1979-01-01

    The vibration environment within air conditioner rotating machinery referred to as an air cycle machine (ACM) was investigated to effectively increase ACM reliability. To assist in the selection of design changes which would result in improved ACM performance, various design modifications were incorporated into a baseline ACM configuration. For each design change, testing was conducted with the best balance achieveable (baseline) and with various degrees of unbalance. Relationships between unbalance (within the context of design changes) and the parameters associated with design goals were established. The results of rotor dynamics tests used to establish these relationships are presented.

  17. Influence of miscibility phenomenon on crystalline polymorph transition in poly(vinylidene fluoride)/acrylic rubber/clay nanocomposite hybrid.

    PubMed

    Abolhasani, Mohammad Mahdi; Naebe, Minoo; Jalali-Arani, Azam; Guo, Qipeng

    2014-01-01

    In this paper, intercalation of nanoclay in the miscible polymer blend of poly(vinylidene fluoride) (PVDF) and acrylic rubber(ACM) was studied. X-ray diffraction was used to investigate the formation of nanoscale polymer blend/clay hybrid. Infrared spectroscopy and X-ray analysis revealed the coexistence of β and γ crystalline forms in PVDF/Clay nanocomposite while α crystalline form was found to be dominant in PVDF/ACM/Clay miscible hybrids. Flory-Huggins interaction parameter (B) was used to further explain the miscibility phenomenon observed. The B parameter was determined by combining the melting point depression and the binary interaction model. The estimated B values for the ternary PVDF/ACM/Clay and PVDF/ACM pairs were all negative, showing both proper intercalation of the polymer melt into the nanoclay galleries and the good miscibility of PVDF and ACM blend. The B value for the PVDF/ACM blend was almost the same as that measured for the PVDF/ACM/Clay hybrid, suggesting that PVDF chains in nanocomposite hybrids interact with ACM chains and that nanoclay in hybrid systems is wrapped by ACM molecules.

  18. Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy.

    PubMed

    Chelko, Stephen P; Asimaki, Angeliki; Andersen, Peter; Bedja, Djahida; Amat-Alarcon, Nuria; DeMazumder, Deeptankar; Jasti, Ravirasmi; MacRae, Calum A; Leber, Remo; Kleber, Andre G; Saffitz, Jeffrey E; Judge, Daniel P

    2016-04-21

    Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 prevents myocyte injury and cardiac dysfunction in vivo in two murine models of ACM at baseline and in response to exercise. SB2-treated mice with desmosome mutations showed improvements in ventricular ectopy and myocardial fibrosis/inflammation as compared with vehicle-treated (Veh-treated) mice. GSK3β inhibition improved left ventricle function and survival in sedentary and exercised Dsg2(mut/mut) mice compared with Veh-treated Dsg2(mut/mut) mice and normalized intercalated disc (ID) protein distribution in both mutant mice. GSK3β showed diffuse cytoplasmic localization in control myocytes but ID redistribution in ACM mice. Identical GSK3β redistribution is present in ACM patient myocardium but not in normal hearts or other cardiomyopathies. SB2 reduced total GSK3β protein levels but not phosphorylated Ser 9-GSK3β in ACM mice. Constitutively active GSK3β worsens ACM in mutant mice, while GSK3β shRNA silencing in ACM cardiomyocytes prevents abnormal ID protein distribution. These results highlight a central role for GSKβ in the complex phenotype of ACM and provide further evidence that pharmacologic GSKβ inhibition improves cardiomyopathies due to desmosome mutations.

  19. Cancer recurrence and mortality after pediatric heart transplantation for anthracycline cardiomyopathy: A report from the Pediatric Heart Transplant Study (PHTS) group.

    PubMed

    Bock, Matthew J; Pahl, Elfriede; Rusconi, Paolo G; Boyle, Gerard J; Parent, John J; Twist, Clare J; Kirklin, James K; Pruitt, Elizabeth; Bernstein, Daniel

    2017-04-04

    We aimed to determine whether malignancy after pediatric HTx for ACM affects overall post-HTx survival. Patients <18y listed for HTx for ACM in the PHTS database between 1993 and 2014 were compared to those with DCM. A 2:1 matched DCM cohort was also compared. Wait-list and post-HTx survival, along with freedom from common HTx complications, were compared. Eighty subjects were listed due to ACM, whereas 1985 were listed for DCM. Although wait-list survival was higher in the ACM group, post-HTx survival was lower for the ACM cohort. Neither difference persisted in the matched cohort analysis. Primary cause of death in the ACM group was infection, which was higher than the DCM group. Malignancy rates were not different. All ACM malignancies were due to PTLD without primary cancer recurrence or SMN. Long-term graft survival after pediatric HTx for ACM is no different than for matched DCM peers, nor is there an increased risk of any malignancy. However, risk of infection and death from infection after HTx are higher in the ACM group. Further studies are needed to assess the effects of prior chemotherapy on susceptibility to infection in this group.

  20. An Assessment of the Appropriateness to the Royal Australian Air Force of a Masters Level Professional Program in Information Systems

    DTIC Science & Technology

    1993-12-01

    Machinery in the development of model curricula for graduate programs in information systems, the identification and validation of the 1982 ACM model...1972 ACM’s C3EM model curricula for graduate programs in IS is called the C3EM Curriculum Model or C3EM Model. In 1979, the C3EM was replaced by the...The present ACM model curriculum covers both undergraduate and graduate programs in IS. Currency of the ACM Model Curriculum. The C2IS has not made any

  1. Evaluation of rotor-bearing system dynamic response to unbalance. [air conditioning equipment

    NASA Technical Reports Server (NTRS)

    Thaller, R. E.; Ozimek, D. W.

    1979-01-01

    The vibration environment within air conditioner rotating machinery referred to as an air cycle machine (ACM) was investigated to effectively increase ACM reliability. To assist in the selection of design changes which would result in improved ACM performance, various design modifications were incorporated into a baseline ACM configuration. For each design change, testing was conducted with the best balance achieveable (baseline) and with various degrees of unbalance. Relationships between unbalance (within the context of design changes) and the parameters associated with design goals were established. The results of rotor dynamics tests used to establish these relationships are presented.

  2. Influence of Miscibility Phenomenon on Crystalline Polymorph Transition in Poly(Vinylidene Fluoride)/Acrylic Rubber/Clay Nanocomposite Hybrid

    PubMed Central

    Abolhasani, Mohammad Mahdi; Naebe, Minoo; Jalali-Arani, Azam; Guo, Qipeng

    2014-01-01

    In this paper, intercalation of nanoclay in the miscible polymer blend of poly(vinylidene fluoride) (PVDF) and acrylic rubber(ACM) was studied. X-ray diffraction was used to investigate the formation of nanoscale polymer blend/clay hybrid. Infrared spectroscopy and X-ray analysis revealed the coexistence of β and γ crystalline forms in PVDF/Clay nanocomposite while α crystalline form was found to be dominant in PVDF/ACM/Clay miscible hybrids. Flory-Huggins interaction parameter (B) was used to further explain the miscibility phenomenon observed. The B parameter was determined by combining the melting point depression and the binary interaction model. The estimated B values for the ternary PVDF/ACM/Clay and PVDF/ACM pairs were all negative, showing both proper intercalation of the polymer melt into the nanoclay galleries and the good miscibility of PVDF and ACM blend. The B value for the PVDF/ACM blend was almost the same as that measured for the PVDF/ACM/Clay hybrid, suggesting that PVDF chains in nanocomposite hybrids interact with ACM chains and that nanoclay in hybrid systems is wrapped by ACM molecules. PMID:24551141

  3. Asbestos release from whole-building demolition of buildings with asbestos-containing material.

    PubMed

    Perkins, Robert A; Hargesheimer, John; Fourie, Walter

    2007-12-01

    The whole-building demolition method, which entails one-or two-story buildings pushed down by heavy equipment, loaded into trucks, and hauled away, is generally the most cost-effective means to remove small buildings. For taller buildings, a crane and wrecking ball may be used initially to reduce the height of the building. Demolitions might release asbestos fibers from friable asbestos-containing material (ACM). Fibers also might be released from nominally nonfriable ACM (Categories I and II nonfriable ACM) if it becomes friable after rough handling throughout the whole-building demolition process. This paper reports on asbestos air monitoring from two demolition projects involving ACM. In one building, Category II nonfriable ACM was present because it could not be removed safely prior to demolition. Both projects had large quantities of gypsum wallboard with ACM joint compound and ACM flooring. One building had large quantities of ACM spray-on ceiling material. During the demolitions personal air monitoring of the workers and area air monitoring downwind and around the sites were conducted. The monitoring found the concentrations of fibers detected by phase contrast microscopy were generally well below the permissible exposure limits (PEL) of workers. Electron microcopy analysis of samples at or near the PEL indicated most of the fibers were not asbestos, and the actual asbestos exposure was often below the detection limit of the procedure. The buildings were kept wet with fire hoses during the demolition and that required large quantities of water, 20,000-60,000 gal/day (75-225 m(3)/day). Earlier studies found little asbestos release from buildings containing only nonfriable ACM demolished by this method. This project found a negligible release of asbestos fibers, despite the presence of nonfriable materials that might become friable, such as ACM joint compound and spray-on ACM ceiling coating.

  4. Automated cardiac output measurements by ultrasound are inaccurate at high cardiac outputs.

    PubMed

    Basdogan, F; Visser, W; Struijk, P C; Jansen, J R; Vletter, W B; Wladimiroff, J W; Lotgering, F K

    2000-06-01

    The sonographic technique of automated cardiac output measurement (ACM) is a promising new method to measure cardiac output and could be of use in a high-risk obstetric unit in the treatment of pre-eclamptic patients. The aim was to determine the accuracy of the ACM method. Comparative study of the sonographic technique of ACM versus cardiac output measured by thermodilution (TD). The study included 39 intensive care patients, 21 men, 13 non-pregnant women and five severely pre-eclamptic pregnant patients, with a wide range of cardiac outputs, in whom TD catheters had been inserted for clinical reasons. Two separate experienced observers, blinded to the results obtained with the other method, performed four successive measurements in each patient with either the ACM or TD technique. The averaged cardiac output value per patient and method was used for comparison. Cardiac output was successfully measured with ACM and TD in 85 and 100% of patients, respectively. Mean cardiac output measured by ACM (6.77 +/- 1.90 L/min) was significantly lower than that measured by TD (9.12 +/- 3.06 L/min). Although cardiac output values obtained with ACM were significantly correlated with those measured by TD, the ACM values were consistently lower than TD values in the higher cardiac output range; the relationship was represented by ACM = 0.35 TD + 3.55 L/min (r = 0.57, P < 0.001). The (ACM - TD) difference increased significantly with cardiac output, through a difference in stroke volume, not in heart rate. The ACM is not an accurate tool to measure cardiac output in patients with a high cardiac output, including treated pre-eclamptic women.

  5. Study of the protective effects of Katha (Heartwood Extract of Acacia catechu) in liver damage induced by iron overload.

    PubMed

    Hazra, Bibhabasu; Sarkar, Rhitajit; Ghate, Nikhil Baban; Chaudhuri, Dipankar; Mandal, Nripendranath

    2013-01-01

    This study evaluated the ameliorating effect of 70% methanol extract of Acacia catechu heartwood, or Katha (ACME) on liver injury induced by iron overload. Iron overload in mice was caused by intraperitoneal administration of 100 mg/kg iron-dextran. ACME was administered orally for 21 days, starting from the day after the first iron-dextran injection. The biochemical markers of hepatic damage and liver iron, protein carbonyl, and hydroxyproline contents were measured in response to the oral administration of ACME. Apart from those, the release of iron from ferritin by ACME was further assessed to determine the efficiency of ACME as an iron-chelating drug. Treatment with different doses of ACME (50, 100, and 200 mg/kg body weight) showed dose-dependent reductions in liver iron, lipid peroxidation, protein oxidation, liver fibrosis, serum enzymes, and ferritin. The antioxidant enzymes levels were enhanced and the reductive release of ferritin iron increased significantly with gradually increasing concentrations of ACME. These results indicate that ACME has a potent hepatoprotective action against hepatic damage induced by iron overload in mice, probably by ameliorating the antioxidant defense activities and reductively releasing ferritin iron.

  6. Assessment of Competencies for Computer Information Systems Curricula.

    ERIC Educational Resources Information Center

    Womble, Myra N.

    1993-01-01

    In a survey of 80 managerial and 130 entry-level computer professionals, most entry workers believed they possessed competencies identified in Association for Computing Machinery (ACM) curricula; most managers did not agree. Most managers rated 28% of ACM competencies moderately to not important; 63% were so rated by entry workers. (SK)

  7. Source localization of intermittent rhythmic delta activity in a patient with acute confusional migraine: cross-spectral analysis using standardized low-resolution brain electromagnetic tomography (sLORETA).

    PubMed

    Kim, Dae-Eun; Shin, Jung-Hyun; Kim, Young-Hoon; Eom, Tae-Hoon; Kim, Sung-Hun; Kim, Jung-Min

    2016-01-01

    Acute confusional migraine (ACM) shows typical electroencephalography (EEG) patterns of diffuse delta slowing and frontal intermittent rhythmic delta activity (FIRDA). The pathophysiology of ACM is still unclear but these patterns suggest neuronal dysfunction in specific brain areas. We performed source localization analysis of IRDA (in the frequency band of 1-3.5 Hz) to better understand the ACM mechanism. Typical IRDA EEG patterns were recorded in a patient with ACM during the acute stage. A second EEG was obtained after recovery from ACM. To identify source localization of IRDA, statistical non-parametric mapping using standardized low-resolution brain electromagnetic tomography was performed for the delta frequency band comparisons between ACM attack and non-attack periods. A difference in the current density maximum was found in the dorsal anterior cingulated cortex (ACC). The significant differences were widely distributed over the frontal, parietal, temporal and limbic lobe, paracentral lobule and insula and were predominant in the left hemisphere. Dorsal ACC dysfunction was demonstrated for the first time in a patient with ACM in this source localization analysis of IRDA. The ACC plays an important role in the frontal attentional control system and acute confusion. This dysfunction of the dorsal ACC might represent an important ACM pathophysiology.

  8. Asteroids, comets, meteors, and their interrelations. Part II: Editorial review

    NASA Astrophysics Data System (ADS)

    Muinonen, Karri; Granvik, Mikael; Penttilä, Antti; Gritsevich, Maria

    2016-04-01

    The Asteroids, Comets, Meteors 2014 (ACM 2014) conference was organized in Helsinki in June 30-July 4, 2014, with the first collection of the peer-reviewed papers published in December 2015 in the Special Issue of Planetary and Space Science (Muinonen et al., 2015). The present issue contains the second collection of papers from ACM 2014.

  9. Combining Opinion Profile Modeling with Complex Context Filtering for Contextual Suggestion

    DTIC Science & Technology

    2015-11-20

    1. H. Fang and C. Zhai. An exploration of axiomatic approaches to information retrieval. In Proceedings of the 28th annual international ACM SIGIR...conference on Research and development in information retrieval, SIGIR ’05, pages 480–487, New York, NY, USA, 2005. ACM . 2. P. Yang and H. Fang. An

  10. Guidance Manual: Asbestos Operations & Maintenance Work Practices. Second Edition.

    ERIC Educational Resources Information Center

    National Inst. of Building Sciences, Washington, DC.

    This technical manual provides detailed guidance to building owners, asbestos program managers, and operations and maintenance (O&M) workers for managing asbestos-containing materials (ACM) in buildings. The manual addresses four different types of ACM found in buildings and three different levels of precaution which may be warranted by…

  11. Human acellular cartilage matrix powders as a biological scaffold for cartilage tissue engineering with synovium-derived mesenchymal stem cells.

    PubMed

    Chang, Chih-Hung; Chen, Chia-Chun; Liao, Cheng-Hao; Lin, Feng-Huei; Hsu, Yuan-Ming; Fang, Hsu-Wei

    2014-07-01

    In our previous study, we found that cartilage fragments from osteoarthritic knee promoted chondrogenesis of mesenchymal stem cells. In this study, we further transformed the cartilage tissues into acellular cartilage matrix (ACM) and explored the feasibility of using ACM as a biological scaffold. Nonworn parts of cartilage tissues were obtained during total knee arthroplasty (TKA) surgery and were successfully fabricated into ACM powders. The ACM powders and human synovium-derived mesenchymal stem cells (SMSCs) were mixed into collagen gel for in vitro culture. Histological results showed a synergistic effect of ACM powders and chondrogenic growth factors in the formation of engineered cartilage. The findings of real-time polymerase chain reaction (PCR) suggested that ACM powders had the potential of promoting type II collagen gene expression in the growth factors-absent environment. Moreover, with growth factors induction, the ACM powders could reduce the hypertrophy in chondrogenesis of SMSCs. In summary, ACM powders could serve as a functional scaffold that benefited the chondrogenesis of SMSCs for cartilage tissue engineering.

  12. Adaptive Patterns of Stress Responsivity: A Preliminary Investigation

    ERIC Educational Resources Information Center

    Del Giudice, Marco; Hinnant, J. Benjamin; Ellis, Bruce J.; El-Sheikh, Mona

    2012-01-01

    The adaptive calibration model (ACM) is an evolutionary-developmental theory of individual differences in stress responsivity. In this article, we tested some key predictions of the ACM in a middle childhood sample (N = 256). Measures of autonomic nervous system activity across the sympathetic and parasympathetic branches validated the 4-pattern…

  13. An advanced condition monitoring system for turbopumps

    NASA Technical Reports Server (NTRS)

    Cross, George S.; Barkhoudarian, Sarkis

    1991-01-01

    Advanced condition monitoring (ACM) technologies developed for in situ turbomachinery applications are reviewed. The ACM concepts are based on direct in situ hardware monitoring and between-flight inspections, using novel real-time, automated, noncontacting, and nonintrusive sensor and associated electronic technologies.

  14. OJPOT: Online Judge & Practice Oriented Teaching Idea in Programming Courses

    ERIC Educational Resources Information Center

    Wang, Gui Ping; Chen, Shu Yu; Yang, Xin; Feng, Rui

    2016-01-01

    Practical abilities are important for students from majors including Computer Science and Engineering, and Electrical Engineering. Along with the popularity of ACM International Collegiate Programming Contest (ACM/ICPC) and other programming contests, online judge (OJ) websites achieve rapid development, thus providing a new kind of programming…

  15. 78 FR 1735 - Airworthiness Directives; Honeywell International Inc. Air Data Pressure Transducers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... fails. Honeywell Service Bulletin ACM/ADC/ADAHRS-34-A01, dated November 6, 2012, specifies to refer to... Bulletin ACM/ADC/ADAHRS-34-A01, dated November 6, 2012, specifies to remove the affected equipment if the... corrective action if the functional test of the ADM accuracy fails. Honeywell Service Bulletin...

  16. Interaction and Critical Inquiry in Asynchronous Computer-Mediated Conferencing: A Research Agenda

    ERIC Educational Resources Information Center

    Hopkins, Joseph; Gibson, Will; Ros i. Sole, Cristina; Savvides, Nicola; Starkey, Hugh

    2008-01-01

    This paper reviews research on learner and tutor interaction in asynchronous computer-mediated (ACM) conferences used in distance learning. The authors note claims made for the potential of ACM conferences to promote higher-order critical inquiry and the social construction of knowledge, and argue that there is a general lack of evidence regarding…

  17. In Situ Optimal Reshading of Arrays with Failed Elements

    DTIC Science & Technology

    2016-06-13

    1982). 2. I. Barrodale and C. Philips, 11 Solution of Overdetermined Systems of linear Equations in the Chebyshev Norm, .. Algorithm 495, ACM Trans...Equations in the l~ Norm With Constraints on the Unknowns, .. Algorithm 635, ACM Trans. on Math. Software, Vol. 11, No. 3, 242-249, (1985). 5. J. T. Lewis

  18. Pi: A Parallel Architecture Interface for Multi-Model Execution

    DTIC Science & Technology

    1990-07-01

    Directory Schemes for Cache Coherence. In The 15th Annual Interna- tional Symposium on Computer Architecture. IEEE Computer Society and ACM, June 1988. [3...Annual International Symposium on Computer Architecture. IEEE Computer Society and ACM, June 1986. [5] Arvind and Rishiyur S. Nikhil. A Dataflow...Overview, 1987. [9] Roberto Bisiani and Alessandro Forin. Multilanguage Parallel Programming of Heterogeneous Machines. IEEE Transactions on Computers

  19. Analyzing Evolving Social Network 2 (EVOLVE2)

    DTIC Science & Technology

    2015-04-01

    ASSIGNED DISTRIBUTION STATEMENT. FOR THE DIRECTOR: / S / / S / TODD WASKIEWICZ MICHAEL J. WESSING Work Unit Manager Deputy Chief...networks: Centrality, communities, and cheeger inequality. In Proceedings of the 20th ACM SIGKDD Conference on Knowledge Discovery and Data Mining (KDD...between dynamics and net- works: Centrality, communities, and cheeger inequality. In Proceedings of the 20th ACM SIGKDD Conference on Knowledge Discovery

  20. OJPOT: Online Judge & Practice Oriented Teaching Idea in Programming Courses

    ERIC Educational Resources Information Center

    Wang, Gui Ping; Chen, Shu Yu; Yang, Xin; Feng, Rui

    2016-01-01

    Practical abilities are important for students from majors including Computer Science and Engineering, and Electrical Engineering. Along with the popularity of ACM International Collegiate Programming Contest (ACM/ICPC) and other programming contests, online judge (OJ) websites achieve rapid development, thus providing a new kind of programming…

  1. Stronger Consistency and Semantics for Low-Latency Geo-Replicated Storage

    DTIC Science & Technology

    2013-06-01

    correctness condition for concurrent objects. ACM TOPLAS, 12(3), 1990. [42] D. Karger, E. Lehman, F. Leighton, M. Levine, D. Lewin , and R. Panigrahy...Satyanarayanan. Disconnected operation in the Coda file system. ACM TOCS, 10(3), February 1992. [44] Tim Kraska, Gene Pang, Michael J. Franklin, and

  2. Adaptive Patterns of Stress Responsivity: A Preliminary Investigation

    ERIC Educational Resources Information Center

    Del Giudice, Marco; Hinnant, J. Benjamin; Ellis, Bruce J.; El-Sheikh, Mona

    2012-01-01

    The adaptive calibration model (ACM) is an evolutionary-developmental theory of individual differences in stress responsivity. In this article, we tested some key predictions of the ACM in a middle childhood sample (N = 256). Measures of autonomic nervous system activity across the sympathetic and parasympathetic branches validated the 4-pattern…

  3. Novel Acetone Metabolism in a Propane-Utilizing Bacterium, Gordonia sp. Strain TY-5▿

    PubMed Central

    Kotani, Tetsuya; Yurimoto, Hiroya; Kato, Nobuo; Sakai, Yasuyoshi

    2007-01-01

    In the propane-utilizing bacterium Gordonia sp. strain TY-5, propane was shown to be oxidized to 2-propanol and then further oxidized to acetone. In this study, the subsequent metabolism of acetone was studied. Acetone-induced proteins were found in extracts of cells induced by acetone, and a gene cluster designated acmAB was cloned on the basis of the N-terminal amino acid sequences of acetone-induced proteins. The acmA and acmB genes encode a Baeyer-Villiger monooxygenase (BVMO) and esterase, respectively. The BVMO encoded by acmA was purified from acetone-induced cells of Gordonia sp. strain TY-5 and characterized. The BVMO exhibited NADPH-dependent oxidation activity for linear ketones (C3 to C10) and cyclic ketones (C4 to C8). Escherichia coli expressing the acmA gene oxidized acetone to methyl acetate, and E. coli expressing the acmB gene hydrolyzed methyl acetate. Northern blot analyses revealed that polycistronic transcription of the acmAB gene cluster was induced by propane, 2-propanol, and acetone. These results indicate that the acmAB gene products play an important role in the metabolism of acetone derived from propane oxidation and clarify the propane metabolism pathway of strain TY-5 (propane → 2-propanol → acetone → methyl acetate → acetic acid + methanol). This paper provides the first evidence for BVMO-dependent acetone metabolism. PMID:17071761

  4. Fluid Analysis of Network Content Dissemination and Cloud Systems

    DTIC Science & Technology

    2017-03-06

    Ferragut, I. Rodríguez F. Paganini, “Optimizing TTL Caches under Heavy-Tailed Demands”, ACM SIGMETRICS, Antibes Juan-les-Pins, France , Jun 2016. [3] A...Co-PI at ACM SIGMETRICS Conference, Juan-Les-Pins, France , Jun 2016. d) Presentation of poster [3] by Co-PI at Stochastic Networks Conference, San

  5. Result Diversity and Entity Ranking Experiments: Anchors, Links, Text and Wikipedia

    DTIC Science & Technology

    2009-11-01

    D. J. Harper, D. H. Kraft, and J. Zobel, editors, SI- GIR , pages 250–257. ACM, 2001. ISBN 1-58113-331- 6. [3] A. P. De Vries, A.-M. Vercoustre, J. A...Westerveld, and D. Hiemstra. The im- portance of prior probabilities for entry page search. In Proceedings of the 25th Annual International ACM SI- GIR

  6. Comparing the Performance of Collection Selection Algorithms

    DTIC Science & Technology

    2003-10-01

    International Con- ference on Management of Data (SIGMOD’97). ACM, New York, 207–218. ACM Transactions on Information Systems, Vol. 21, No. 4, October 2003...september98/powell/09powell.html. SILVERSTEIN, C., HENZINGER, M., MARAIS, H., AND MORICZ , M. 1999. Analysis of a very large Web Search Engine Query

  7. 48 CFR 801.690-5 - Requirements for contracting authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... Appeals of decisions may be made to the VA ACM and the decisions of the ACM shall be final. (e) Skills... fiscal years to stay abreast of current acquisition knowledge and skills as mandated by OFPP. The HCA... of study at an accredited college or university: accounting, business, finance, law, contracts...

  8. Technical Manual for Batteries, Navy Lithium Safety Program Responsibilities and Procedures

    DTIC Science & Technology

    2004-08-19

    chloride battery manufactured by Acme Battery Manufacturers, Inc. The battery is a single cell, hermetically sealed lithium / thionyl chloride ...reserve lithium / thionyl chloride battery manufactured by Acme Battery Manufacturers, Inc. The battery is a single cell, hermetically sealed... lithium / thionyl chloride system with a mechanical activation mechanism. The system is currently in development by the Army and is proposed for use by

  9. Concave Surround Optics for Rapid Multi-View Imaging

    DTIC Science & Technology

    2006-11-01

    M. Bolas University of Southern California School of Cinematic Arts Los Angeles, CA 90089 I. McDowall Fakespace Labs Mountain View, CA 94043...Chen, B, Vaish, V., Horowitz, I., McDowall, I., Bolas , M., 2004: “Synthetic Aperture Confocal Imaging”, ACM Transactions. on Graphics (Proc. ACM

  10. High Average Current Electron Guns for High-Power FELs

    DTIC Science & Technology

    2009-12-09

    20 A/cm2, while more advanced cathodes (with controlled porosity) can generate up to ~ 100 A/cm2. Single crystal cathodes such as lanthanum ...polycrystalline form of carbon that will operate at high temperatures and has improved strength and uniformity compared to grids made of tungsten or

  11. Machine-Checked Metatheory for Security-Oriented Languages

    DTIC Science & Technology

    2006-08-23

    for Alice represents an integer readable only by principal Alice . In this system, any user can build secret computa- tions for any other. To...first ACM SIGPLAN symposium on Haskell, pages 13-24, New York, NY, USA, 2008. ACM. [46] Andrei Sabelfeld and Andrew C. Myers. Language-based

  12. Design of an Information Technology Undergraduate Program to Produce IT Versatilists

    ERIC Educational Resources Information Center

    Koohang, Alex; Riley, Liz; Smith, Terry; Floyd, Kevin

    2010-01-01

    This paper attempts to present a model for designing an IT undergraduate program that is based on the recommendations of the Association for Computer Machinery/Institute of Electrical and Electronics Engineers--Information Technology (ACM/IEEE--IT) Curriculum Model. The main intent is to use the ACM/IEEE--IT Curriculum Model's recommendations as a…

  13. Integrating Information Assurance and Security into IT Education: A Look at the Model Curriculum and Emerging Practice

    ERIC Educational Resources Information Center

    Dark, Melissa Jane; Ekstrom, Joseph J.; Lunt, Barry M.

    2006-01-01

    In December 2001 a meeting of interested parties from fifteen four-year IT programs from the US along with representatives from IEEE, ACM, and ABET (CITC-1) began work on the formalization of Information Technology as an accredited academic discipline. The effort has evolved into SIGITE, the ACM SIG for Information Technology Education. During…

  14. Do adaptive comanagement processes lead to adaptive comanagement outcomes? A multicase study of long-term outcomes associated with the national riparian service team's place-based riparian assistance

    Treesearch

    Jill A. Smedstad; Hannah. Gosnell

    2013-01-01

    Adaptive comanagement (ACM) is a novel approach to environmental governance that combines the dynamic learning features of adaptive management with the linking and network features of collaborative management. There is growing interest in the potential for ACM to resolve conflicts around natural resource management and contribute to greater social and ecological...

  15. Kernel Loadable Wrappers for Information Assurance

    DTIC Science & Technology

    2002-09-01

    Bressoud and Schneider [2] for building a replication hypervisor that intercepts, buffers, and distributes signals from outside the system. • Special... Bressoud and Fred Schneider. Hypervisor-based Fault-Tolerance. Proceedings of the 15th ACM Symposium on Operating System Principles. December 1995. ACM

  16. Collaboration Technology in Military Operations: Lessons Learned from the Corporate Domain

    DTIC Science & Technology

    2006-02-01

    and, thus, providing updates are often neglected, especially when people are busy (Begole, 2005; Nagel & Abowd , 2002; Scupelli, Kiesler, Fussell...Objects. In Proceedings of CHI 2004. ACM Conference on Human Factors in Computing Systems, Vienna, Austria, ACM Press, pp. 375-382. Nagel, K.S. & Abowd , G.D

  17. Sound and Complete Elimination of Singleton Kinds

    DTIC Science & Technology

    2000-01-01

    Karl Crary and Stephanie Weirich . Flexible type analysis. In 1999 ACM International Conference on Functional Programming, pages 233-248, Paris...September 1999. [3] Karl Crary, Stephanie Weirich , and Greg Morrisett. Intensional polymorphism in type-erasure seman- tics. In 1998 ACM International

  18. Design of an Information Technology Undergraduate Program to Produce IT Versatilists

    ERIC Educational Resources Information Center

    Koohang, Alex; Riley, Liz; Smith, Terry; Floyd, Kevin

    2010-01-01

    This paper attempts to present a model for designing an IT undergraduate program that is based on the recommendations of the Association for Computer Machinery/Institute of Electrical and Electronics Engineers--Information Technology (ACM/IEEE--IT) Curriculum Model. The main intent is to use the ACM/IEEE--IT Curriculum Model's recommendations as a…

  19. Integrating Information Assurance and Security into IT Education: A Look at the Model Curriculum and Emerging Practice

    ERIC Educational Resources Information Center

    Dark, Melissa Jane; Ekstrom, Joseph J.; Lunt, Barry M.

    2006-01-01

    In December 2001 a meeting of interested parties from fifteen four-year IT programs from the US along with representatives from IEEE, ACM, and ABET (CITC-1) began work on the formalization of Information Technology as an accredited academic discipline. The effort has evolved into SIGITE, the ACM SIG for Information Technology Education. During…

  20. Designing Graphic Presentations from First Principles

    DTIC Science & Technology

    1998-01-01

    Interpretability issues are discussed in chapter 5. 109 Los Angeles San Jose San Francisco Lucky’s Safeway Los Angeles San Jose San Francisco Fry’s Acme Lucky’s... Safeway Los Angeles San Jose San Francisco Fry’s Acme Supermarket Chains Population Composite Presentation Figure 4.20: Inexact composition

  1. Effect of electrolyte concentration on performance of supercapacitor carbon electrode from fibers of oil palm empty fruit bunches

    NASA Astrophysics Data System (ADS)

    Farma, R.; Deraman, M.; Talib, I. A.; Awitdrus, Omar, R.; Ishak, M. M.; Taer, E.; Basri, N. H.; Dolah, B. N. M.

    2015-04-01

    Fibers of oil palm empty fruit bunches were used to produce self-adhesive carbon grains (SACG). The SACG green monoliths were carbonized in N2 environment at 800°C to produce carbon monoliths (CM) and the CM was CO2 activated at 800°C for 4 hour to produce activated carbon monolith electrodes (ACM). The physical properties of the CMs and ACMs were investigated using X-ray diffraction, field emission scanning electron microscopy and nitrogen adsorption-desorption. ACMs were used as electrode to fabricate symmetry supercapacitor cells and the cells which used H2SO4 electrolyte at 0.5, 1.0 and 1.5 M were investigated using electrochemical impedance spectroscopy, cyclic voltammetry and galvanostatic charge-discharge standard techniques. In this paper we report the physical properties of the ACM electrodes and the effect of electrolyte concentration on the electrochemical properties the ACM electrodes.

  2. Y1Ba2Cu3O7-δ thin films grown by magnetron sputtering

    NASA Astrophysics Data System (ADS)

    Takano, Satoshi; Hayashi, Noriki; Okuda, Shigeru; Hitosuyanagi, Hajime

    1989-12-01

    Y1Ba2Cu3O7-δ thin films were grown on (100)MgO and polycrystalline YSZ substrates by RF magnetron sputtering. We measured the magnetic field dependence of Jc of these films. The films grown on MgO with Jc of 4.0x106, 2.9 x106 and 1.5x104 A/cm2 at OT showed 7.1x105 A/cm2 at 8T, 1x104 A/cm2 at 20T and 1.1x103 A/cm2 at 5 T, respectively . We could attain a c-axis oriented film with a Jc of 1.2x104 A/cm2 on YSZ polycrystalline substrate, however, it showed greater degradation than the films grown on MgO in Jc with magnetic field.

  3. Y 1Ba 2Cu 3O 7-δ thin films grown by magnetron sputtering

    NASA Astrophysics Data System (ADS)

    Takano, Satoshi; Hayashi, Noriki; Okuda, Shigeru; Hitosuyanagi, Hajime

    1989-12-01

    Y 1Ba 2Cu 3O 7-δ thin films were grown on (100)MgO and polycrystalline YSZ substrates by RF magnetron sputtering. We measured the magnetic field dependence of Jc of these films. The films grown on MgO with Jc of 4.0x10 6, 2.9 x10 6 and 1.5x10 4 A/cm 2 at OT showed 7.1x10 5 A/cm 2 at 8T, 1x10 4 A/cm 2 at 20T and 1.1x10 3 A/cm 2 at 5 T, respectively . We could attain a c-axis oriented film with a Jc of 1.2x10 4 A/cm 2 on YSZ polycrystalline substrate, however, it showed greater degradation than the films grown on MgO in Jc with magnetic field.

  4. Radioimmunoassay for aclacinomycin A.

    PubMed

    Matsuzawa, Y; Kiyosaki, T; Oki, T; Takeuchi, T; Umezawa, H

    1982-04-01

    An antibody against aclacinomycin A (ACM) was produced in a rabbit by immunization with ACM-bovine serum albumin conjugate. The radioimmunoassay (RIA) was based on the competition of unlabeled anthracycline with 3H-labeled ACM for binding sites on a specific antibody. Antibody-bound and free antigen were separated by selective adsorption on dextran-coated charcoal. The antibody reacted equally with ACM and its metabolites, MA144 M1, MA144 S1 and aklavin, and could precisely distinguish aklavinone-related aglycones, adriamycin and daunomycin. RIA was sensitive in the range of 1 approximately 10 pmol per assay. The quantities of ACM and its metabolites in human plasma were practically determined without any pretreatment of physiological samples.

  5. Biophenols and antioxidant properties of Australian canola meal.

    PubMed

    Obied, Hassan K; Song, Yi; Foley, Sonia; Loughlin, Michael; Rehman, Ata-ur; Mailer, Rodney; Masud, Tariq; Agboola, Samson

    2013-09-25

    During the extraction of canola oil, large quantities of meal are produced. Extracting biophenols from Australian canola meal (ACM) adds value to an otherwise low-value agro-industrial byproduct. This study examined the biophenol content and the antioxidant activity of ACM, the impact of extraction conditions, and varietal differences. Sinapine was the principal biophenol in ACM. In crude and hydrolyzed extracts, 31 compounds were identified: 2 dihexosides, 2 organic acids, 4 glucosinolates, 17 sinapic acid derivatives, 2 cyclic spermidine alkaloids, caffeic acid and its dihexoside, kaempferol, and its C-glucoside. ACM showed significant free radical scavenging activity in DPPH(•) and ABTS(•+) assays. Sinapine was the chief contributor to ACM antioxidant activity, whereas kaempferol sinapoyl triglucoside isomer was the most potent antioxidant. Biophenol content ranged between 12.8 and 15.4 mg GAE/g DW. Differences among studied cultivars were generally quantitative. The Tarcoola cultivar showed the highest biophenol content and antioxidant activity.

  6. Modulation of visceral fat adipokine secretion by dietary fatty acids and ensuing changes in skeletal muscle inflammation.

    PubMed

    Tishinsky, Justine M; De Boer, Anna A; Dyck, David J; Robinson, Lindsay E

    2014-01-01

    Given the link between obesity and insulin resistance, the role of adipose-derived factors in communicating with skeletal muscle to affect its function is important. We sought to determine if high fat diets modulate visceral adipose tissue (VAT) adipokines with subsequent effects on skeletal muscle inflammation and insulin sensitivity. Rats were fed (i) low fat (LF), (ii) high saturated fatty acid (SFA), or (iii) high SFA with n-3 polyunsaturated fatty acid (SFA/n-3 PUFA) diets for 4 weeks. VAT-derived adipokines were measured in adipose conditioned medium (ACM) after 72 h. Next, skeletal muscles from LF-fed rats were incubated for 8 h in (i) control buffer (CON), (ii) CON with 2 mmol·L(-1) palmitate (PALM, positive control), (iii) ACM from LF, (iv) ACM from SFA, or (v) ACM from SFA/n-3 PUFA. ACM from rats fed SFA and SFA/n-3 PUFA had increased (P ≤ 0.05) interleukin-6 (IL-6) (+31%) and monocyte chemoattractant protein-1 (MCP-1) (+30%). Adiponectin was decreased (-29%, P ≤ 0.05) in ACM from SFA, and this was prevented in SFA/n-3 PUFA ACM. Toll-like receptor 4 (TLR4) gene expression was increased (P ≤ 0.05) in PALM soleus muscle (+356%) and all ACM groups (+175%-191%). MCP-1 gene expression was elevated (P ≤ 0.05) in PALM soleus muscle (+163%) and soleus muscle incubated in ACM from animals fed SFA (+159%) and SFA/n-3 PUFA (+151%). Glucose transport was impaired (P ≤ 0.05) in PALM muscles but preserved in ACM groups. Acute exposure of muscle to fatty acid modulated adipokines affects skeletal muscle inflammatory gene expression but not insulin sensitivity.

  7. RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer.

    PubMed

    Feng, Chan; Li, Xiaoyan; Dong, Chunyan; Zhang, Xuemei; Zhang, Xie; Gao, Yong

    2015-01-01

    In this study, long-circulating Arg-Gly-Asp (RGD)-modified aclacinomycin A (ACM) liposomes were prepared by thin film hydration method. Their morphology, particle size, encapsulation efficiency, and in vitro release were investigated. The RGD-ACM liposomes was about 160 nm in size and had the visual appearance of a yellowish suspension. The zeta potential was -22.2 mV and the encapsulation efficiency was more than 93%. The drug-release behavior of the RGD-ACM liposomes showed a biphasic pattern, with an initial burst release and followed by sustained release at a constant rate. After being dissolved in phosphate-buffered saline (pH 7.4) and kept at 4°C for one month, the liposomes did not aggregate and still had the appearance of a milky white colloidal solution. In a pharmacokinetic study, rats treated with RGD-ACM liposomes showed slightly higher plasma concentrations than those treated with ACM liposomes. Maximum plasma concentrations of RGD-ACM liposomes and ACM liposomes were 4,532 and 3,425 ng/mL, respectively. RGD-ACM liposomes had a higher AUC0-∞ (1.54-fold), mean residence time (2.09-fold), and elimination half-life (1.2-fold) when compared with ACM liposomes. In an in vivo study in mice, both types of liposomes inhibited growth of human lung adenocarcinoma (A549) cells and markedly decreased tumor size when compared with the control group. There were no obvious pathological tissue changes in any of the treatment groups. Our results indicate that RGD-modified ACM liposomes have a better antitumor effect in vivo than their unmodified counterparts.

  8. Evaluating adaptive co-management as conservation conflict resolution: Learning from seals and salmon.

    PubMed

    Butler, J R A; Young, J C; McMyn, I A G; Leyshon, B; Graham, I M; Walker, I; Baxter, J M; Dodd, J; Warburton, C

    2015-09-01

    By linking iterative learning and knowledge generation with power-sharing, adaptive co-management (ACM) provides a potential solution to resolving complex social-ecological problems. In this paper we evaluate ACM as a mechanism for resolving conservation conflict using a case study in Scotland, where seal and salmon fishery stakeholders have opposing and entrenched objectives. ACM emerged in 2002, successfully resolving this long-standing conflict. Applying evaluation approaches from the literature, in 2011 we interviewed stakeholders to characterise the evolution of ACM, and factors associated with its success over 10 years. In common with other ACM cases, triggers for the process were shifts in slow variables controlling the system (seal and salmon abundance, public perceptions of seal shooting), and exogenous shocks (changes in legal mandates, a seal disease outbreak). Also typical of ACM, three phases of evolution were evident: emerging local leadership preparing the system for change, a policy window of opportunity, and stakeholder partnerships building the resilience of the system. Parameters maintaining ACM were legal mechanisms and structures, legal power held by government, and the willingness of all stakeholders to reach a compromise and experiment with an alternative governance approach. Results highlighted the critical role of government power and support in resolving conservation conflict, which may constrain the extent of local stakeholder-driven ACM. The evaluation also demonstrated how, following perceived success, the trajectory of ACM has shifted to a 'stakeholder apathy' phase, with declining leadership, knowledge exchange, stakeholder engagement, and system resilience. We discuss remedial actions required to revive the process, and the importance of long term government resourcing and alternative financing schemes for successful conflict resolution. Based on the results we present a generic indicator framework and participatory method for the

  9. Precursor salt assisted syntheses of high-index faceted concave hexagon and nanorod-like polyoxometalates

    NASA Astrophysics Data System (ADS)

    Pal, Jaya; Ganguly, Mainak; Mondal, Chanchal; Negishi, Yuichi; Pal, Tarasankar

    2014-12-01

    This paper describes an effective method for a precursor salt assisted fabrication and reshaping of two different polyoxometalates [(NH4)2Cu(MoO4)2 (ACM) and Cu3(MoO4)2(OH)2 (CMOH)] into five distinctive shapes through straightforward and indirect routes. Explicit regulation of the structural arrangements of ACM and CMOH has been studied in detail with altered precursor salt concentration employing our laboratory developed modified hydrothermal (MHT) method. Morphologically different ACM 3D architectures are evolved with higher molybdate concentration, whereas 1D growth of CMOH is observed with increased copper concentration. Interesting morphological transformation of the products has been accomplished employing one precursor salt at a time without using any other foreign reagent. It has been proven that large ACMs become labile in the presence of incoming Cu(ii) and NH4+ ions of the precursor salts. A new strategy for the conversion of faceted ACMs (hexagonal plate, circular plate and hollow flower) to exclusive CMOH nanorods through a Cu(ii) assisted reaction has been adopted. According to thermodynamic consideration, the synthesis of rare concave nanostructures with high index facet is still challenging due to their higher reactivity. In this study, concave hexagonal ACM with high index facet {hkl} has been successfully prepared for the first time from hexagonal ACM through simple etching with ammonium heptamolybdate (AHM), which is another precursor salt. Hexagonal ACM corrugates to a concave hexagon because of the higher reactivity of the {001} crystal plane than that of the {010} plane. It has been shown that high index facet exposed concave hexagonal ACM serves as a better catalyst for the photodegradation of dye than the other microstructures enclosed by low index facets.This paper describes an effective method for a precursor salt assisted fabrication and reshaping of two different polyoxometalates [(NH4)2Cu(MoO4)2 (ACM) and Cu3(MoO4)2(OH)2 (CMOH)] into

  10. Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells.

    PubMed

    Shumakovich, Marina A; Mencio, Caitlin P; Siglin, Jonathan S; Moriarty, Rebecca A; Geller, Herbert M; Stroka, Kimberly M

    2017-08-09

    Tumor cell metastasis to the brain involves cell migration through biochemically and physically complex microenvironments at the blood-brain barrier (BBB). The current understanding of tumor cell migration across the BBB is limited. We hypothesize that an interplay between biochemical cues and physical cues at the BBB affects the mechanisms of brain metastasis. We found that astrocyte conditioned medium (ACM) applied directly to tumor cells increased tumor cell velocity, induced elongation, and promoted actin stress fiber organization. Notably, treatment of the extracellular matrix with ACM led to even more significant increases in tumor cell velocity in comparison with ACM treatment of cells directly. Furthermore, inhibiting matrix metalloproteinases in ACM reversed ACM's effect on tumor cells. The effects of ACM on tumor cell morphology and migration also depended on astrocytes' activation state. Finally, using a microfluidic device, we found that the effects of ACM were abrogated in confinement. Overall, our work demonstrates that astrocyte-secreted factors alter migration and morphology of metastatic breast tumor cells, and this effect depends on the cells' mechanical microenvironment.-Shumakovich, M. A., Mencio, C. P., Siglin, J. S., Moriarty, R. A., Geller, H. M., Stroka, K. M. Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells. © FASEB.

  11. Nitrogen-doped porous carbon monoliths from polyacrylonitrile (PAN) and carbon nanotubes as electrodes for supercapacitors

    PubMed Central

    Wang, Yanqing; Fugetsu, Bunshi; Wang, Zhipeng; Gong, Wei; Sakata, Ichiro; Morimoto, Shingo; Hashimoto, Yoshio; Endo, Morinobu; Dresselhaus, Mildred; Terrones, Mauricio

    2017-01-01

    Nitrogen-doped porous activated carbon monoliths (NDP-ACMs) have long been the most desirable materials for supercapacitors. Unique to the conventional template based Lewis acid/base activation methods, herein, we report on a simple yet practicable novel approach to production of the three-dimensional NDP-ACMs (3D-NDP-ACMs). Polyacrylonitrile (PAN) contained carbon nanotubes (CNTs), being pre-dispersed into a tubular level of dispersions, were used as the starting material and the 3D-NDP-ACMs were obtained via a template-free process. First, a continuous mesoporous PAN/CNT based 3D monolith was established by using a template-free temperature-induced phase separation (TTPS). Second, a nitrogen-doped 3D-ACM with a surface area of 613.8 m2/g and a pore volume 0.366 cm3/g was obtained. A typical supercapacitor with our 3D-NDP-ACMs as the functioning electrodes gave a specific capacitance stabilized at 216 F/g even after 3000 cycles, demonstrating the advantageous performance of the PAN/CNT based 3D-NDP-ACMs. PMID:28074847

  12. Nitrogen-doped porous carbon monoliths from polyacrylonitrile (PAN) and carbon nanotubes as electrodes for supercapacitors

    NASA Astrophysics Data System (ADS)

    Wang, Yanqing; Fugetsu, Bunshi; Wang, Zhipeng; Gong, Wei; Sakata, Ichiro; Morimoto, Shingo; Hashimoto, Yoshio; Endo, Morinobu; Dresselhaus, Mildred; Terrones, Mauricio

    2017-01-01

    Nitrogen-doped porous activated carbon monoliths (NDP-ACMs) have long been the most desirable materials for supercapacitors. Unique to the conventional template based Lewis acid/base activation methods, herein, we report on a simple yet practicable novel approach to production of the three-dimensional NDP-ACMs (3D-NDP-ACMs). Polyacrylonitrile (PAN) contained carbon nanotubes (CNTs), being pre-dispersed into a tubular level of dispersions, were used as the starting material and the 3D-NDP-ACMs were obtained via a template-free process. First, a continuous mesoporous PAN/CNT based 3D monolith was established by using a template-free temperature-induced phase separation (TTPS). Second, a nitrogen-doped 3D-ACM with a surface area of 613.8 m2/g and a pore volume 0.366 cm3/g was obtained. A typical supercapacitor with our 3D-NDP-ACMs as the functioning electrodes gave a specific capacitance stabilized at 216 F/g even after 3000 cycles, demonstrating the advantageous performance of the PAN/CNT based 3D-NDP-ACMs.

  13. Orion Launch Abort Vehicle Attitude Control Motor Testing

    NASA Technical Reports Server (NTRS)

    Murphy, Kelly J.; Brauckmann, Gregory J.; Paschal, Keith B.; Chan, David T.; Walker, Eric L.; Foley, Robert; Mayfield, David; Cross, Jared

    2011-01-01

    Current Orion Launch Abort Vehicle (LAV) configurations use an eight-jet, solid-fueled Attitude Control Motor (ACM) to provide required vehicle control for all proposed abort trajectories. Due to the forward position of the ACM on the LAV, it is necessary to assess the effects of jet-interactions (JI) between the various ACM nozzle plumes and the external flow along the outside surfaces of the vehicle. These JI-induced changes in flight control characteristics must be accounted for in developing ACM operations and LAV flight characteristics. A test program to generate jet interaction aerodynamic increment data for multiple LAV configurations was conducted in the NASA Ames and NASA Langley Unitary Plan Wind Tunnels from August 2007 through December 2009. Using cold air as the simulant gas, powered subscale models were used to generate interaction data at subsonic, transonic, and supersonic test conditions. This paper presents an overview of the complete ACM JI experimental test program for Orion LAV configurations, highlighting ACM system modeling, nozzle scaling assumptions, experimental test techniques, and data reduction methodologies. Lessons learned are discussed, and sample jet interaction data are shown. These data, in conjunction with computational predictions, were used to create the ACM JI increments for all relevant flight databases.

  14. Arrhythmogenic cardiomyopathy: a disease of intercalated discs.

    PubMed

    Calore, Martina; Lorenzon, Alessandra; De Bortoli, Marzia; Poloni, Giulia; Rampazzo, Alessandra

    2015-06-01

    Arrhythmogenic cardiomyopathy (ACM) is an acquired progressive disease having an age-related penetrance and showing clinical manifestations usually during adolescence and young adulthood. It is characterized clinically by a high incidence of severe ventricular tachyarrhythmias and sudden cardiac death and pathologically by degeneration of ventricular cardiomyocytes with replacement by fibro-fatty tissue. Whereas, in the past, the disease was considered to involve only the right ventricle, more recent clinical studies have established that the left ventricle is frequently involved. ACM is an inherited disease in up to 50% of cases, with predominantly an autosomal dominant pattern of transmission, although recessive inheritance has also been described. Since most of the pathogenic mutations have been identified in genes encoding desmosomal proteins, ACM is currently defined as a disease of desmosomes. However, on the basis of the most recent description of the intercalated disc organization and of the identification of a novel ACM gene encoding for an area composita protein, ACM can be considered as a disease of the intercalated disc, rather than only as a desmosomal disease. Despite increasing knowledge of the genetic basis of ACM, we are just beginning to understand early molecular events leading to cardiomyocyte degeneration, fibrosis and fibro-fatty substitution. This review summarizes recent advances in our comprehension of the link between the molecular genetics and pathogenesis of ACM and of the novel role of cardiac intercalated discs.

  15. Effect of carbonization temperature on the physical and electrochemical properties of supercapacitor electrode from fibers of oil palm empty fruit bunches

    NASA Astrophysics Data System (ADS)

    Ishak, M. M.; Deraman, M.; Talib, I. A.; Basri, N. H.; Awitdrus, Farma, R.; Taer, E.; Omar, R.; Nor, N. S. M.; Dolah, B. N. M.

    2015-04-01

    Self-adhesive carbon grains (SACG) was prepared from fibers of oil palm empty fruit bunches. The SACG green monoliths were carbonized in N2 environment at 400, 500, 600 and 700°C to produce carbon monoliths labeled as CM1, CM2, CM3 and CM4 respectively. The CMs were activated in CO2 surrounding at 800°C for 1 hour to produce activated carbon monolith electrodes (ACM1, ACM2, ACM3 and ACM4). The physical properties of the CMs and ACMs were investigated using X-ray diffraction, field emission scanning electron microscopy (FESEM) and N2 adsorption-desorption isotherm techniques. ACMs were used as electrode to fabricate symmetry supercapacitor cells and the cells' performances were investigated using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and galvanostatic charge-discharge (GCD) standard techniques. In this paper we report the physical and electrochemical properties of the ACM electrodes by analyzing the influence of the carbonization temperature on these properties.

  16. Effect of carbonization temperature on the physical and electrochemical properties of supercapacitor electrode from fibers of oil palm empty fruit bunches

    SciTech Connect

    Ishak, M. M.; Deraman, M. Talib, I. A.; Basri, N. H.; Omar, R.; Nor, N. S. M.; Dolah, B. N. M.; Awitdrus,; Farma, R.; Taer, E.

    2015-04-16

    Self-adhesive carbon grains (SACG) was prepared from fibers of oil palm empty fruit bunches. The SACG green monoliths were carbonized in N{sub 2} environment at 400, 500, 600 and 700°C to produce carbon monoliths labeled as CM1, CM2, CM3 and CM4 respectively. The CMs were activated in CO{sub 2} surrounding at 800°C for 1 hour to produce activated carbon monolith electrodes (ACM1, ACM2, ACM3 and ACM4). The physical properties of the CMs and ACMs were investigated using X-ray diffraction, field emission scanning electron microscopy (FESEM) and N{sub 2} adsorption-desorption isotherm techniques. ACMs were used as electrode to fabricate symmetry supercapacitor cells and the cells’ performances were investigated using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and galvanostatic charge-discharge (GCD) standard techniques. In this paper we report the physical and electrochemical properties of the ACM electrodes by analyzing the influence of the carbonization temperature on these properties.

  17. The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion.

    PubMed

    Papke, Roger L; Zheng, Guangrong; Horenstein, Nicole A; Dwoskin, Linda P; Crooks, Peter A

    2005-09-01

    The alpha7 nAChR subtype is of particular interest as a potential therapeutic target since it has been implicated as a mediator of both cognitive and neuroprotective activity. The rigid nicotine analog ACME and the N-cyanoborane conjugate ACME-B are selective partial agonists of rat alpha7 receptors expressed in Xenopus oocytes, with no significant activation of either alpha3beta4 or alpha4beta2 receptors. ACME-B is both more potent and efficacious than ACME. The efficacies of ACME-B and ACME are approximately 26% and 10% of the efficacy of ACh, respectively. Similar N-conjugation of S(-)nicotine with cyanoborane decreased efficacy for alpha3beta4 and alpha4beta2 receptors, as well as for alpha7 nAChR. Structural comparison of ACME with the benzylidene anabaseines, another class of previously identified alpha7-selective agonists, suggests that they share a similar structural motif that may be applicable to other alpha7-selective agonists.

  18. Astrocyte-conditioned medium protecting hippocampal neurons in primary cultures against corticosterone-induced damages via PI3-K/Akt signal pathway.

    PubMed

    Zhu, Ze-Hua; Yang, Ru; Fu, Xin; Wang, Yan-Qing; Wu, Gen-Cheng

    2006-10-09

    Prolonged or excessive exposure to corticosterone leads to neuronal damages in the brain regions, including hippocampus. We reported that astrocyte-conditioned medium (ACM) protected the neurons of the primary hippocampal cultures against the corticosterone-induced damages. Corticosterone added to the cultures resulted in a significant number of TUNEL-positive cells. However, corticosterone-induced TUNEL labeling was suppressed as for ACM-cultured neurons. To delineate the molecular basis underlying the neuroprotection of ACM, we assessed the activation of ERK1/2 and (PI3-K)/Akt signal pathways in response to corticosterone-induced neuronal damages. Western blot test revealed that corticosterone increased the phosphorylation of ERK1/2 and PI3-K/Akt in hippocampal neurons grown in Neurobasal medium supplemented with B27 and 500 microm L-glutamine (NBM+). Interestingly, the increase of phospho-ERK1/2 and Akt levels was much pronounced and the time course of phosphorylation was altered in ACM, suggesting that both signaling pathways might participate in ACM protection. Furthermore, the selective inhibitor of Akt, rather than ERK1/2, blocked the neuroprotective activity against corticosterone in ACM-cultured neurons. In summary, our data showed that ACM had a potent neuroprotective effect in cultured neurons. PI3-K/Akt signal pathway, but not ERK1/2, was involved in the protective activity against the corticosterone-induced damages.

  19. Clinical evaluation of an air-capsule technique for the direct measurement of intra-abdominal pressure after elective abdominal surgery

    PubMed Central

    Otto, Jens; Kaemmer, Daniel; Biermann, Andreas; Jansen, Marc; Dembinski, Rolf; Schumpelick, Volker; Schachtrupp, Alexander

    2008-01-01

    Background The gold standard for assessment of intraabdominal pressure (IAP) is via intravesicular pressure measurement (IVP). This accepted technique has some inherent problems, e.g. indirectness. Aim of this clinical study was to assess direct IAP measurement using an air-capsule method (ACM) regarding complications risks and agreement with IVP in patients undergoing abdominal surgery. Methods A prospective cohort study was performed in 30 patients undergoing elective colonic, hepatic, pancreatic and esophageal resection. For ACM a Probe 3 (Spiegelberg®, Germany) was placed on the greater omentum. It was passed through the abdominal wall paralleling routine drainages. To compare ACM with IVP t-testing was performed and mean difference as well as limits of agreement were calculated. Results ACM did not lead to complications particularly with regard to organ lesion or surgical site infection. Mean insertion time of ACM was 4.4 days (min-max: 1–5 days). 168 pairwise measurements were made. Mean ACM value was 7.9 ± 2.7 mmHg while mean IVP was 8.4 ± 3.0 mmHg (n.s). Mean difference was 0.4 mmHg ± 2.2 mmHg. Limits of agreement were -4.1 mmHg to 5.1 mmHg. Conclusion Using ACM, direct IAP measurement is feasible and uncomplicated. Associated with relatively low pressure ranges (<17 mmHg), results are comparable to bladder pressure measurement. PMID:18925973

  20. Role of the aclacinomycin A--doxorubicin association in reversal of doxorubicin resistance in K562 tumour cells.

    PubMed Central

    Millot, J. M.; Rasoanaivo, T. D.; Morjani, H.; Manfait, M.

    1989-01-01

    Acquired resistance to anthracyclines is characterised by a lower sensitivity to these agents, associated with impaired accumulation of drug. We have examined the ability of aclacinomycin A (ACM) associated with doxorubicin (DOX), to increase intranuclear DOX concentrations and, consequently, to enhance cytotoxic effects against drug resistant cells in vitro. A recently developed microspectrofluorometric technique is used to measure intranuclear DOX concentrations in sensitive and DOX-resistant K562 cells treated with DOX and ACM. Fluorescence emission spectra are collected from a microvolume of single living cell nuclei. From both DOX and ACM model fluorescence spectra (free, DNA-bound and metabolites), the intranuclear spectral profile is analysed according to the amount of each component. This quantitative analysis determines intranuclear DOX concentrations with an error of 10%. Non-cytotoxic doses of ACM, in combination with DOX, increase cytotoxic activity of DOX against K562 resistant cells. When DOX-resistant cells are exposed simultaneously to ACM and DOX, significant increases in intranuclear DOX concentrations are found compared with the case of exposure to DOX alone. The measure of the intranuclear retention of DOX shows that ACM partly blocks the DOX efflux in resistant cell nuclei, resulting in enhanced accumulation of DOX. These data lead us to conclude that ACM-DOX association partly reverses the DOX resistance at clinically achievable concentrations. PMID:2803945

  1. Nitrogen-doped porous carbon monoliths from polyacrylonitrile (PAN) and carbon nanotubes as electrodes for supercapacitors.

    PubMed

    Wang, Yanqing; Fugetsu, Bunshi; Wang, Zhipeng; Gong, Wei; Sakata, Ichiro; Morimoto, Shingo; Hashimoto, Yoshio; Endo, Morinobu; Dresselhaus, Mildred; Terrones, Mauricio

    2017-01-11

    Nitrogen-doped porous activated carbon monoliths (NDP-ACMs) have long been the most desirable materials for supercapacitors. Unique to the conventional template based Lewis acid/base activation methods, herein, we report on a simple yet practicable novel approach to production of the three-dimensional NDP-ACMs (3D-NDP-ACMs). Polyacrylonitrile (PAN) contained carbon nanotubes (CNTs), being pre-dispersed into a tubular level of dispersions, were used as the starting material and the 3D-NDP-ACMs were obtained via a template-free process. First, a continuous mesoporous PAN/CNT based 3D monolith was established by using a template-free temperature-induced phase separation (TTPS). Second, a nitrogen-doped 3D-ACM with a surface area of 613.8 m(2)/g and a pore volume 0.366 cm(3)/g was obtained. A typical supercapacitor with our 3D-NDP-ACMs as the functioning electrodes gave a specific capacitance stabilized at 216 F/g even after 3000 cycles, demonstrating the advantageous performance of the PAN/CNT based 3D-NDP-ACMs.

  2. Acemetacin cocrystal structures by powder X-ray diffraction

    PubMed Central

    Bolla, Geetha

    2017-01-01

    Cocrystals of acemetacin drug (ACM) with nicotinamide (NAM), p-aminobenzoic acid (PABA), valerolactam (VLM) and 2-pyridone (2HP) were prepared by melt crystallization and their X-ray crystal structures determined by high-resolution powder X-ray diffraction. The powerful technique of structure determination from powder data (SDPD) provided details of molecular packing and hydrogen bonding in pharmaceutical cocrystals of acemetacin. ACM–NAM occurs in anhydrate and hydrate forms, whereas the other structures crystallized in a single crystalline form. The carboxylic acid group of ACM forms theacid–amide dimer three-point synthon R 3 2(9)R 2 2(8)R 3 2(9) with three different syn amides (VLM, 2HP and caprolactam). The conformations of the ACM molecule observed in the crystal structures differ mainly in the mutual orientation of chlorobenzene fragment and the neighboring methyl group, being anti (type I) or syn (type II). ACM hydrate, ACM—NAM, ACM–NAM-hydrate and the piperazine salt of ACM exhibit the type I conformation, whereas ACM polymorphs and other cocrystals adopt the ACM type II conformation. Hydrogen-bond interactions in all the crystal structures were quantified by calculating their molecular electrostatic potential (MEP) surfaces. Hirshfeld surface analysis of the cocrystal surfaces shows that about 50% of the contribution is due to a combination of strong and weak O⋯H, N⋯H, Cl⋯H and C⋯H interactions. The physicochemical properties of these cocrystals are under study. PMID:28512568

  3. Precursor salt assisted syntheses of high-index faceted concave hexagon and nanorod-like polyoxometalates.

    PubMed

    Pal, Jaya; Ganguly, Mainak; Mondal, Chanchal; Negishi, Yuichi; Pal, Tarasankar

    2015-01-14

    This paper describes an effective method for a precursor salt assisted fabrication and reshaping of two different polyoxometalates [(NH4)2Cu(MoO4)2 (ACM) and Cu3(MoO4)2(OH)2 (CMOH)] into five distinctive shapes through straightforward and indirect routes. Explicit regulation of the structural arrangements of ACM and CMOH has been studied in detail with altered precursor salt concentration employing our laboratory developed modified hydrothermal (MHT) method. Morphologically different ACM 3D architectures are evolved with higher molybdate concentration, whereas 1D growth of CMOH is observed with increased copper concentration. Interesting morphological transformation of the products has been accomplished employing one precursor salt at a time without using any other foreign reagent. It has been proven that large ACMs become labile in the presence of incoming Cu(II) and NH4(+) ions of the precursor salts. A new strategy for the conversion of faceted ACMs (hexagonal plate, circular plate and hollow flower) to exclusive CMOH nanorods through a Cu(II) assisted reaction has been adopted. According to thermodynamic consideration, the synthesis of rare concave nanostructures with high index facet is still challenging due to their higher reactivity. In this study, concave hexagonal ACM with high index facet {hkl} has been successfully prepared for the first time from hexagonal ACM through simple etching with ammonium heptamolybdate (AHM), which is another precursor salt. Hexagonal ACM corrugates to a concave hexagon because of the higher reactivity of the {001} crystal plane than that of the {010} plane. It has been shown that high index facet exposed concave hexagonal ACM serves as a better catalyst for the photodegradation of dye than the other microstructures enclosed by low index facets.

  4. Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes.

    PubMed

    Yamada, Shinnosuke; Nagai, Taku; Nakai, Tsuyoshi; Ibi, Daisuke; Nakajima, Akira; Yamada, Kiyofumi

    2014-05-01

    Increasing epidemiological evidence indicates that prenatal infection and childhood central nervous system infection with various viral pathogens enhance the risk for several neuropsychiatric disorders. Polyriboinosinic-polyribocytidilic acid (polyI:C) is known to induce strong innate immune responses that mimic immune activation by viral infections. Our previous findings suggested that activation of the innate immune system in astrocytes results in impairments of neurite outgrowth and spine formation, which lead to behavioral abnormalities in adulthood. To identify candidates of astrocyte-derived humoral factors that affect neuronal development, we analyzed astrocyte-conditioned medium (ACM) from murine astrocyte cultures treated with polyI:C (polyI:C-ACM) by two-dimensional fluorescence difference gel electrophoresis (2D-DIGE). Through a quantitative proteomic screen, we found that 13 protein spots were differentially expressed compared with ACM from vehicle-treated astrocytes (control-ACM), and characterized one of the candidates, matrix metalloproteinase-3 (Mmp3). PolyI:C treatment significantly increased the expression levels of Mmp3 mRNA and protein in astrocytes, but not microglia. PolyI:C-ACM was associated with significantly higher Mmp3 protein level and enzyme activity than control-ACM. The addition of recombinant Mmp3 into control-ACM impaired dendritic elongation of primary cultured hippocampal neurons, while the deleterious effect of polyI:C-ACM on neurite elongation was attenuated by knockdown of Mmp3 in astrocytes. These results suggest that Mmp3 is a possible mediator of polyI:C-ACM-induced neurodevelopmental impairment.

  5. Cross-linked xenogenic collagen implantation in the sheep model for vaginal surgery.

    PubMed

    Endo, Masayuki; Urbankova, Iva; Vlacil, Jaromir; Sengupta, Siddarth; Deprest, Thomas; Klosterhalfen, Bernd; Feola, Andrew; Deprest, Jan

    The properties of meshes used in reconstructive surgery affect the host response and biomechanical characteristics of the grafted tissue. Whereas durable synthetics induce a chronic inflammation, biological grafts are usually considered as more biocompatible. The location of implantation is another determinant of the host response: the vagina is a different environment with specific function and anatomy. Herein, we evaluated a cross-linked acellular collagen matrix (ACM), pretreated by the anti-calcification procedure ADAPT® in a sheep model for vaginal surgery. Ten sheep were implanted with a cross-linked ACM, and six controls were implanted with a polypropylene (PP; 56 g/m(2)) control. One implant was inserted in the lower rectovaginal septum, and one was used for abdominal wall defect reconstruction. Grafts were removed after 180 days; all graft-related complications were recorded, and explants underwent bi-axial tensiometry and contractility testing. Half of ACM-implanted animals had palpable induration in the vaginal implantation area, two of these also on the abdominal implant. One animal had a vaginal exposure. Vaginal ACMs were 63 % less stiff compared to abdominal ACM explants (p = 0.01) but comparable to vaginal PP explants. Seven anterior vaginal ACM explants showed areas of graft degradation on histology. There was no overall difference in vaginal contractility. Considering histologic degradation in the anterior vaginal implant as representative for the host, posterior ACM explants of animals with degradation had a 60 % reduced contractility as compared to PP (p = 0.048). Three abdominal implants showed histologic degradation; those were more compliant than non-degraded implants. Vaginal implantation with ACM was associated with graft-related complications (GRCs) and biomechanical properties comparable to PP. Partially degraded ACM had a decreased vaginal contractility.

  6. Glutamate promotes neural stem cell proliferation by increasing the expression of vascular endothelial growth factor of astrocytes in vitro.

    PubMed

    Liu, C X; Xu, X; Chen, X L; Yang, P B; Zhang, J S; Liu, Y

    2015-09-20

    The high levels of glutamate might involve in neurogenesis after brain injuries. However, the mechanisms are not fully understood. In this study, we investigated the effect of glutamate on the proliferation of rat embryonic neural stem/progenitor cells (NSCs) through regulating the vascular endothelial growth factor (VEGF) expression of astrocytes (ASTs) in vitro, and the cyclin D1 expression of NSCs. The results showed that glutamate promoted the expression and secretion of VEGF of rat astrocytes by activating group I mGluRs. Astrocyte conditioned medium-containing Glu [ACM (30%)] promoted the proliferation of embryonic NSCs compared with normal astrocyte conditioned medium+Glu [N-ACM (30%)+Glu (30 μM)] by increasing cell activity, diameter of neurospheres, bromodeoxyuridine (BrdU) incorporation and cell division; while ACM+VEGF neutralizing antibody [ACM (30%)+VEGF NAb (15 μg/ml)] significantly inhibited the proliferation of embryonic NSCs compared with ACM (30%). ACM (30%) increased the expressions of cyclin D1 and decreased cell death compared with N-ACM (30%)+Glu (30 μM). ACM (30%)+VEGF NAb (15 μg/ml) decreased the expressions of cyclin D1 and increased cell death compared with ACM (30%). These results demonstrated that glutamate could also indirectly promote the proliferation of rat embryonic NSCs through inducing the VEGF expression of ASTs in vitro, and VEGF may increase the expression of cyclin D1. These finding suggest that glutamate may be a major molecule for regulating embryonic NSC proliferation and facilitate neural repair in the process of NSC transplants after brain injuries.

  7. Early Fungicidal Activity as a Candidate Surrogate Endpoint for All-Cause Mortality in Cryptococcal Meningitis: A Systematic Review of the Evidence

    PubMed Central

    Montezuma-Rusca, Jairo M.; Powers, John H.; Follmann, Dean; Wang, Jing; Sullivan, Brigit; Williamson, Peter R.

    2016-01-01

    Background Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality. In clinical trials evaluating treatments for CM, biomarkers of early fungicidal activity (EFA) in cerebrospinal fluid (CSF) have been proposed as candidate surrogate endpoints for all- cause mortality (ACM). However, there has been no systematic evaluation of the group-level or trial-level evidence for EFA as a candidate surrogate endpoint for ACM. Methods We conducted a systematic review of randomized trials in treatment of CM to evaluate available evidence for EFA measured as culture negativity at 2 weeks/10 weeks and slope of EFA as candidate surrogate endpoints for ACM. We performed sensitivity analysis on superiority trials and high quality trials as determined by Cochrane measures of trial bias. Results Twenty-seven trials including 2854 patients met inclusion criteria. Mean ACM was 15.8% at 2 weeks and 27.0% at 10 weeks with no overall significant difference between test and control groups. There was a statistically significant group-level correlation between average EFA and ACM at 10 weeks but not at 2 weeks. There was also no statistically significant group-level correlation between CFU culture negativity at 2weeks/10weeks or average EFA slope at 10 weeks. A statistically significant trial-level correlation was identified between EFA slope and ACM at 2 weeks, but is likely misleading, as there was no treatment effect on ACM. Conclusions Mortality remains high in short time periods in CM clinical trials. Using published data and Institute of Medicine criteria, evidence for use of EFA as a surrogate endpoint for ACM is insufficient and could provide misleading results from clinical trials. ACM should be used as a primary endpoint evaluating treatments for cryptococcal meningitis. PMID:27490100

  8. CNTF-Treated Astrocyte Conditioned Medium Enhances Large-Conductance Calcium-Activated Potassium Channel Activity in Rat Cortical Neurons.

    PubMed

    Sun, Meiqun; Liu, Hongli; Xu, Huanbai; Wang, Hongtao; Wang, Xiaojing

    2016-08-01

    Seizure activity is linked to astrocyte activation as well as dysfunctional cortical neuron excitability produced from changes in calcium-activated potassium (KCa) channel function. Ciliary neurotrophic factor-treated astrocyte conditioned medium (CNTF-ACM) can be used to investigate the peripheral effects of activated astrocytes upon cortical neurons. However, CNTF-ACM's effect upon KCa channel activity in cultured cortical neurons has not yet been investigated. Whole-cell patch clamp recordings were performed in rat cortical neurons to evaluate CNTF-ACM's effects upon charybdotoxin-sensitive large-conductance KCa (BK) channel currents and apamin-sensitive small-conductance KCa (SK) channel current. Biotinylation and RT-PCR were applied to assess CNTF-ACM's effects upon the protein and mRNA expression, respectively, of the SK channel subunits SK2 and SK3 and the BK channel subunits BKα1 and BKβ3. An anti-fibroblast growth factor-2 (FGF-2) monoclonal neutralizing antibody was used to assess the effects of the FGF-2 component of CNTF-ACM. CNTF-ACM significantly increased KCa channel current density, which was predominantly attributable to gains in BK channel activity (p < 0.05). CNTF-ACM produced a significant increase in BKα1 and BKβ3 expression (p < 0.05) but had no significant effect upon SK2 or SK3 expression (p > 0.05). Blocking FGF-2 produced significant reductions in KCa channel current density (p > 0.05) as well as BKα1 and BKβ3 expression in CNTF-ACM-treated neurons (p > 0.05). CNTF-ACM significantly enhances BK channel activity in rat cortical neurons and that FGF-2 is partially responsible for these effects. CNTF-induced astrocyte activation results in secretion of neuroactive factors which may affect neuronal excitability and resultant seizure activity in mammalian cortical neurons.

  9. Multilinear Computing and Multilinear Algebraic Geometry

    DTIC Science & Technology

    2016-08-10

    landmark paper titled “Most tensor problems are NP-hard” (see [14] in Section 3) in the Journal of the ACM , the premier journal in Computer Science...Multi-Valued Data, Springer-Verlag, Berlin Heidel- berg, 2014. [14] C. J. Hillar and L.-H. Lim, “Most tensor problems are NP-hard,” J. ACM , 60 (2013...Data, Springer-Verlag, Berlin Heidelberg, 2014. C.J. Hillar and L.-H. Lim, "Most tensor problems are NP-hard," Journal of the ACM , 60 (2013), no. 6, Art

  10. Aclacinomycin A sensitizes K562 chronic myeloid leukemia cells to imatinib through p38MAPK-mediated erythroid differentiation.

    PubMed

    Lee, Yueh-Lun; Chen, Chih-Wei; Liu, Fu-Hwa; Huang, Yu-Wen; Huang, Huei-Mei

    2013-01-01

    Expression of oncogenic Bcr-Abl inhibits cell differentiation of hematopoietic stem/progenitor cells in chronic myeloid leukemia (CML). Differentiation therapy is considered to be a new strategy for treating this type of leukemia. Aclacinomycin A (ACM) is an antitumor antibiotic. Previous studies have shown that ACM induced erythroid differentiation of CML cells. In this study, we investigate the effect of ACM on the sensitivity of human CML cell line K562 to Bcr-Abl specific inhibitor imatinib (STI571, Gleevec). We first determined the optimal concentration of ACM for erythroid differentiation but not growth inhibition and apoptosis in K562 cells. Then, pretreatment with this optimal concentration of ACM followed by a minimally toxic concentration of imatinib strongly induced growth inhibition and apoptosis compared to that with simultaneous co-treatment, indicating that ACM-induced erythroid differentiation sensitizes K562 cells to imatinib. Sequential treatment with ACM and imatinib induced Bcr-Abl down-regulation, cytochrome c release into the cytosol, and caspase-3 activation, as well as decreased Mcl-1 and Bcl-xL expressions, but did not affect Fas ligand/Fas death receptor and procaspase-8 expressions. ACM/imatinib sequential treatment-induced apoptosis was suppressed by a caspase-9 inhibitor and a caspase-3 inhibitor, indicating that the caspase cascade is involved in this apoptosis. Furthermore, we demonstrated that ACM induced erythroid differentiation through the p38 mitogen-activated protein kinase (MAPK) pathway. The inhibition of erythroid differentiation by p38MAPK inhibitor SB202190, p38MAPK dominant negative mutant or p38MAPK shRNA knockdown, reduced the ACM/imatinib sequential treatment-mediated growth inhibition and apoptosis. These results suggest that differentiated K562 cells induced by ACM-mediated p38MAPK pathway become more sensitive to imatinib and result in down-regulations of Bcr-Abl and anti-apoptotic proteins, growth inhibition and

  11. Real Time Filtering of Tweets Using Wikipedia Concepts and Google Tri-gram Semantic Relatedness

    DTIC Science & Technology

    2015-11-20

    retrieval. ACM , 2013, pp. 17–20. [2] A. Islam, E. Milios, and V. Kešelj, “Text similarity using google tri-grams,” in Proceedings of the 25th Canadian...Resnick, and Q. Mei, “Req-rec: High recall retrieval with query pooling and interactive classification,” in Proceedings of the 37th international ACM ...SIGIR conference on Research & development in information retrieval. ACM , 2014, pp. 163–172. [5] C. Zhai and J. Lafferty, “A study of smoothing

  12. Microstructure and Mechanical Properties of Porous Mullite

    NASA Astrophysics Data System (ADS)

    Hsiung, Chwan-Hai Harold

    Mullite (3 Al2O3 : 2 SiO2) is a technologically important ceramic due to its thermal stability, corrosion resistance, and mechanical robustness. One variant, porous acicular mullite (ACM), has a unique needle-like microstructure and is the material platform for The Dow Chemical Company's diesel particulate filter AERIFY(TM). The investigation described herein focuses on the microstructure-mechanical property relationships in acicular mullites as well as those with traditional porous microstructures with the goal of illuminating the critical factors in determining their modulus, strength, and toughness. Mullites with traditional pore morphologies were made to serve as references via slipcasting of a kaolinite-alumina-starch slurry. The starch was burned out to leave behind a pore network, and the calcined body was then reaction-sintered at 1600C to form mullite. The samples had porosities of approximately 60%. Pore size and shape were altered by using different starch templates, and pore size was found to influence the stiffness and toughness. The ACM microstructure was varied along three parameters: total porosity, pore size, and needle size. Total porosity was found to dominate the mechanical behavior of ACM, while increases in needle and pore size increased the toughness at lower porosities. ACM was found to have much improved (˜130%) mechanical properties relative to its non-acicular counterpart at the same porosity. A second set of investigations studied the role of the intergranular glassy phase which wets the needle intersections of ACM. Removal of the glassy phase via an HF etch reduced the mechanical properties by ˜30%, highlighting the intergranular phase's importance to the enhanced mechanical properties of ACM. The composition of the glassy phase was altered by doping the ACM precursor with magnesium and neodymium. Magnesium doping resulted in ACM with greatly reduced fracture strength and toughness. Studies showed that the mechanical properties of the

  13. Adaptive Patterns of Stress Responsivity: A Preliminary Investigation

    PubMed Central

    Del Giudice, Marco; Hinnant, J. Benjamin; Ellis, Bruce J.; El-Sheikh, Mona

    2014-01-01

    The adaptive calibration model (ACM) is an evolutionary–developmental theory of individual differences in stress responsivity. In this article, we tested some key predictions of the ACM in a middle childhood sample (N = 256). Measures of autonomic nervous system activity across the sympathetic and parasympathetic branches validated the 4-pattern taxonomy of the ACM via finite mixture modeling. Moreover, the 4 patterns of responsivity showed the predicted associations with family stress levels but no association with measures of ecological stress. Our hypotheses concerning sex differences in responsivity were only partly confirmed. This preliminary study provides initial support for the key predictions of the ACM and highlights some of the methodological challenges that will need to be considered in future research on this topic. PMID:22148947

  14. 40 CFR 763.83 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... means an airtight, impermeable, permanent barrier around ACBM to prevent the release of asbestos fibers..., the Trust Territory of the Pacific Islands, and the Virgin Islands. Surfacing ACM means...

  15. 40 CFR 763.83 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... means an airtight, impermeable, permanent barrier around ACBM to prevent the release of asbestos fibers..., the Trust Territory of the Pacific Islands, and the Virgin Islands. Surfacing ACM means...

  16. 40 CFR 763.83 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... means an airtight, impermeable, permanent barrier around ACBM to prevent the release of asbestos fibers..., the Trust Territory of the Pacific Islands, and the Virgin Islands. Surfacing ACM means...

  17. 40 CFR 763.83 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... means an airtight, impermeable, permanent barrier around ACBM to prevent the release of asbestos fibers..., the Trust Territory of the Pacific Islands, and the Virgin Islands. Surfacing ACM means...

  18. 40 CFR 763.83 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... means an airtight, impermeable, permanent barrier around ACBM to prevent the release of asbestos fibers..., the Trust Territory of the Pacific Islands, and the Virgin Islands. Surfacing ACM means...

  19. 78 FR 51816 - Notice of Actions on Special Permit Applications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... Mast (ACM) configured with a non-DOT specification pressure vessel containing anhydrous ammonia. (modes... ion battery which is permanently installed in a cell phone case as ``Lithium batteries contained...

  20. "The Need to Know": 1994 Senior Researcher Award Acceptance Address.

    ERIC Educational Resources Information Center

    Carlsen, James C.

    1994-01-01

    Discusses issues related to music education research. Presents three criteria to guide selection of research topics. Concludes that the challenge for music researchers is to avoid research that merely supports a "favored" methodology. (ACM)

  1. Preservice Teachers in Secondary Social Studies: Examining Conceptions and Practices.

    ERIC Educational Resources Information Center

    Wilson, Elizabeth K.; And Others

    1994-01-01

    Reports on a study of 11 preservice teachers' beliefs and practices about secondary social studies education. Finds that the preservice teachers held positive conceptions about social studies, stressing active learning techniques and knowledge construction. (ACM)

  2. Research Publications.

    ERIC Educational Resources Information Center

    Yarbrough, Cornelia, Comp.

    1994-01-01

    Asserts that research can provide a cutting edge for the profession and essential information for teachers as they plan new instructional strategies, evaluation techniques, and advocacy efforts. Presents an annotated bibliography of 17 items related to music education research. (ACM)

  3. Perspectives: Technology as Content in Social Studies Curricula for Young Learners.

    ERIC Educational Resources Information Center

    Gooler, Dennis D., Ed.

    1995-01-01

    Maintains that elementary social studies teachers who wish to engage students in the social studies must see educational technology as both instructional tools and as content. Concludes that technological literacy will become as important as science or civic literacy. (ACM)

  4. In vitro and in vivo evaluation of chitosan microspheres with different deacetylation degree as potential embolic agent.

    PubMed

    Zhou, Xuan; Kong, Ming; Cheng, Xiao Jie; Feng, Chao; Li, Jing; Li, Jing Jing; Chen, Xi Guang

    2014-11-26

    To evaluate the potential of N-acetylated chitosan microspheres used as a chemoembolic agent in vivo and in vitro. Calibrated spherical chitosan microspheres (CMs) were prepared via Water-in-Oil emulsification method and CMs were acetylated (ACMs). The swelling rate of CMs was greatly affected by pH than that of ACMs and both of them affected by temperature. Microspheres with excellent thermal stability demonstrated controllable degradation in lysozyme solution. Doxorubicin was released from microspheres in vitro and exhibited excellent control release profile. ACMs caused hemolysis less than CMs (<5% of the time). Co-culture with mouse embryo fibroblasts revealed that microspheres have non-cytotoxic nature. Microspheres planted in a rat gluteal muscle demonstrated that it were biodegradable and biocompatible. ACMs were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular occlusion after 15 days. Acetylated chitosan microspheres could be used as potential biocompatible and biodegradable embolic agents.

  5. Environmental Assessment: Construct New Mini-Storage Facility Okeechobee Road Eglin Air Force Base Florida

    DTIC Science & Technology

    2006-09-01

    or flood plains. No lead-based paints (LBP), asbestos containing materials (ACM), underground storage tanks , or Environmental Restoration Program remediation sites or areas of concern exist at the site.

  6. Construct a Test and Integration Laboratory Eglin Air Force Base Florida

    DTIC Science & Technology

    2004-02-01

    storage tanks , or Environmental Restoration Program remediation sites or areas of concem exist at the site....species, and contains no surface water, wetlands, or flood plains. No lead-based paints (LBP), asbestos containing materials (ACM), underground

  7. Tradeoffs Between Synchronization, Communication, and Work in Parallel Linear Algebra Computations

    DTIC Science & Technology

    2014-01-25

    2001. [24] A. Tiskin. Communication-efficient parallel generic pairwise elimination. Future Generation Computer Systems , 23(2):179 – 188, 2007. [25] S. Warshall. A theorem on boolean matrices. J. ACM, 9:11–12, January 1962. 17

  8. Superfund record of decision (EPA Region 9): Yuma Marine Corps Air Station, Operable Unit 2, Yuma, AZ, December 2, 1997

    SciTech Connect

    1998-10-01

    This Record of Decision (ROD) for Operable Unit (OU2) documents the remedial action plan for OU2 at Marine Corps Air Station (MCAS), Yuma, Arizona. On the basis of the data collected at the OU2 sites, no further action is necessary for 12 of the 18 CAOCs included in OU2, because these sites do not pose a threat to human health or the environment. However, remedial action is required to protect human health and comply with regulatory requirements at three of the CAOCs in OU2 because of the presence of ACM. Under this alternative, ACM fragment visible on soil surfaces would be collected manually. Collection would include removing approximately the upper inch of soil beneath the ACM to reduce the potential for asbestos fibers remaining behind in the soil. The ACM and soils would be stockpiled, manifested, loaded, transported, and disposed of at a permitted facility.

  9. 40 CFR 763.80 - Scope and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., sampling such materials if they are not assumed to be ACM, and having samples analyzed by appropriate... required to use persons who have been accredited to conduct inspections, reinspections, develop management...

  10. [Evaluation of plans for reclamation from products containing asbestos to ensure safety to the workers and the general population].

    PubMed

    Di Lorenzo, L; Corfiati, M; Giangaspero, G; Spaccavento, D S; Ria, W; Soleo, L

    2007-01-01

    Fifty-two working plans for abatement of asbestos-containing materials (ACM) were examined being presented over 12 months at a Public Occupational Health Service in Apulia (Italy) by authorized companies. Most of the interventions took place in urban areas and civil buildings and lasted few days with employment of a limited number of workers. They mainly consisted in removal practices. The weight of ACM abated varied from 30 to over 14,000 kg. Air monitoring of asbestos fibres was included not in all plans. When airborne fibres were detectable, the threshold of environmental pollution (20ff/L) was sometimes reached or exceeded. This finding appeared to be relevant for asbestos exposure of workers and general population. A higher fibre dispersion occurred during abatement of amounts of ACM more than 1,000 kg. The Occupational Health Service should be legally and operatively able to make regular workplace inspections, especially when large quantities of ACM have to be abated.

  11. 76 FR 41822 - In the Matter of Certain Toner Cartridges and Components Thereof; Notice of Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ..., California; Alpha Image Tech of South El Monte, California; ACM Technologies, Inc. of Corona, California... include a full statement of the reasons why the Commission should grant such treatment. See 19 C.F.R....

  12. Lower Mississippi River Environmental Program. Report 9. An Ecological Investigation of Revetted and Natural Bank Habitats in the Lower Mississippi River

    DTIC Science & Technology

    1988-03-01

    Table B2 (Concluded) Fort Adams Revetment Shipek ACM Taxon Grab Hess Slabs Annelida Naididae Stylurus sp. 24 Tubificidae Tubificidae (nc)** 49...Polycentropiidae Neureclipsis sp. 1 Turbellaria Tricladida Dugesia tigrina 316 Nematoda 24 Annelida Oligochaeta Tubificidae Branchiura sowerbyi 607

  13. Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima.

    PubMed

    Huang, Shyh-Shyun; Chiu, Chuan-Sung; Lin, Tsung-Hui; Lee, Min-Min; Lee, Chao-Ying; Chang, Shu-Jen; Hou, Wen-Chi; Huang, Guan-Jhong; Deng, Jeng-Shyan

    2013-05-20

    Centipeda minima (L.) is traditionally used in Chinese folk medicine for the treatments of rhinitis, sinusitis, relieving pain, reducing swelling, and treating cancer for a long history in Taiwan. However, there is no scientific evidence which supports the use in the literature. The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of the aqueous extract of Centipeda minima (ACM). The following activities were investigated: antioxidant activities [2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), DPPH (1,1-diphenyl-2-picrylhydrazyl)], and anti-inflammatory [lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 macrophages and paw-edema induced by λ-carrageenan (Carr)]. We also investigated the anti-inflammatory mechanism of ACM via studies of the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and the levels of malondialdehyde (MDA) in the edema paw. Serum NO, tumor necrosis factor α (TNF-α), and interleukin-1β (IL-1β) were also measured in vivo. In HPLC analysis, the fingerprint chromatogram of ACM was established. ACM showed the highest TEAC and DPPH radical scavenging activities, respectively. ACM also had highest contents of polyphenol and flavonoid contents. We evaluated that ACM and the reference compound of protocatechualdehyde and caffeic acid decreased the LPS-induced NO production in RAW264.7 cells. Administration of ACM showed a concentration dependent inhibition on paw edema development after Carr treatment in mice. The anti-inflammatory effects of ACM could be via NO, TNF-α, and IL-1β suppressions and associated with the increase in the activities of antioxidant enzymes. Western blotting revealed that ACM decreased Carr-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions. Anti-inflammatory mechanisms of ACM might be correlated to the decrease in the level of Malondialdehyde (MDA), iNOS, and COX-2 via

  14. Algorithm Design for Computational Fluid Dynamics, Scientific Visualization, and Image Processing

    DTIC Science & Technology

    2007-01-29

    ACM TOG 22, 871-878 (2003). "• [1TF] Irving, G., Teran , J. and Fedkiw, R., "Invertible Finite Elements for Robust Simulation of Large Deformation" ACM...34• [MBTF] Molino, N., Bridson, R., Teran , J. and Fedkiw, R., "A Crystalline, Red Green Strategy for Meshing Highly Deformable Objects with Tetrahedra...34, 12th Int. Meshing Roundtable, 103-114, 2003. "* [BTMF] Bridson, R., Teran , J., Molino, N. and Fedkiw, R., "Adaptive Physics Based Tetrahedral Mesh

  15. Higher current density operation with EB reticle writer EBM-5000

    NASA Astrophysics Data System (ADS)

    Saito, Masato; Ugajin, Kunihiro; Higaki, Tomotaka; Nishino, Hideaki; Watanabe, Hidehiro

    2006-05-01

    The performance of electron beam reticle writer EBM-5000(NFT) was examined with higher current density. The current density was raised up to 70A/cm2 against to its standard current density 50A/cm2, and sufficiently good results were obtained with that operating condition. We concluded that the performance with that operating condition was good enough to produce photomasks for 65nm node devices.

  16. Ada (Trade Name) Bibliography. Volume 1.

    DTIC Science & Technology

    1983-05-01

    A SOFTWARE TRANSITION TOOL FILIPSKI, GARY L.; MOORE, DONALD R.; NEWTON, JOHN E. DOCUMENT NUMBER: 3312 TYPE: JOURNAL ARTICLE ACM SIGPLAN NOTICES VOL 15...AGENCYARLINGTON,VA TRANSFORMATION OF ADA PROGRAMS INTO SILICON ORGANICK, DR. ELLIOTT I. ; LINDSTROM, GARY ; SMITH, D.K. ; SUBRAHMANYAM, T. CARTER; CARTER, T. M... GARY DOCUMENT NUMBER: 4104 TYPE: JOURNAL ARTICLE ACM ADA LETTERS VOL 2 ISSUE 1 PP. 33-49 This article discusses the design and development of the

  17. Software Assurance Curriculum Project Volume 4: Community College Education

    DTIC Science & Technology

    2011-09-01

    Interim Revision of CS 2001.” Computing Curriculum Series. [ACM 2008] Allen, Julia H.; Barnum , Sean; Ellison, Robert J.; McGraw, Gary; & Mead, Nancy R...Allen, Julia H.; Barnum , Sean; Ellison, Robert J.; McGraw, Gary; & Mead, Nancy R. Software Security Engineering: A Guide for Project Managers [Allen...Computing Curriculum Series. [ACM 2008] Allen, Julia H.; Barnum , Sean; Ellison, Robert J.; McGraw, Gary; & Mead, Nancy R. Software Security

  18. Air cycle machine for an aircraft environmental control system

    NASA Technical Reports Server (NTRS)

    Decrisantis, Angelo A. (Inventor); O'Coin, James R. (Inventor); Taddey, Edmund P. (Inventor)

    2010-01-01

    An ECS system includes an ACM mounted adjacent an air-liquid heat exchanger through a diffuser that contains a diffuser plate. The diffuser plate receives airflow from the ACM which strikes the diffuser plate and flows radially outward and around the diffuser plate and into the air-liquid heat exchanger to provide minimal pressure loss and proper flow distribution into the air-liquid heat exchanger with significantly less packaging space.

  19. Conditioned medium from human amniotic epithelial cells may induce the differentiation of human umbilical cord blood mesenchymal stem cells into dopaminergic neuron-like cells.

    PubMed

    Yang, Shu; Sun, Hai-Mei; Yan, Ji-Hong; Xue, Hong; Wu, Bo; Dong, Fang; Li, Wen-Shuai; Ji, Feng-Qing; Zhou, De-Shan

    2013-07-01

    Dopaminergic (DA) neuron therapy has been established as a new clinical tool for treating Parkinson's disease (PD). Prior to cell transplantation, there are two primary issues that must be resolved: one is the appropriate seed cell origin, and the other is the efficient inducing technique. In the present study, human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) were used as the available seed cells, and conditioned medium from human amniotic epithelial cells (ACM) was used as the inducing reagent. Results showed that the proportion of DA neuron-like cells from hUCB-MSCs was significantly increased after cultured in ACM, suggested by the upregulation of DAT, TH, Nurr1, and Pitx3. To identify the process by which ACM induces DA neuron differentiation, we pretreated hUCB-MSCs with k252a, the Trk receptor inhibitor of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), and found that the proportion of DA neuron-like cells was significantly decreased compared with ACM-treated hUCB-MSCs, suggesting that NGF and BDNF in ACM were involved in the differentiation process. However, we could not rule out the involvement of other unidentified factors in the ACM, because ACM + k252a treatment does not fully block DA neuron-like cell differentiation compared with control. The transplantation of ACM-induced hUCB-MSCs could ameliorate behavioral deficits in PD rats, which may be associated with the survival of engrafted DA neuron-like cells. In conclusion, we propose that hUCB-MSCs are a good source of DA neuron-like cells and that ACM is a potential inducer to obtain DA neuron-like cells from hUCB-MSCs in vitro for an ethical and legal cell therapy for PD.

  20. Separation of Benign and Malicious Network Events for Accurate Malware Family Classification

    DTIC Science & Technology

    2015-09-28

    Sundaravel, “Fast malware classification by automated behavioral graph matching,” in ACM CSIIR Workshop , 2010. [3] K. Rieck, P. Trinius, C. Willems, and T...A close look on n-grams in intrusion detection: anomaly detection vs. classification ,” in ACM workshop on Artificial intelligence and security...ABSTRACT 16. SECURITY CLASSIFICATION OF: Labeling malware samples with their appropriate malware family helps understand and track malware evolution and

  1. A Principled Approach to Managing Routing in Large ISP Networks

    DTIC Science & Technology

    2009-06-01

    interface to a migration-aware data-plane hypervisor. Our prototype presents a rudimentary data-plane hypervi- sor implementation which only supports...INFOCOM, March 2005. [20] C.-K. Chau. Policy-based routing with non-strict preferences. In Proc. ACM SIGCOMM, 2006. [21] E. Chen, R. Fernando , J...Hoffman, J. Snell, and T. Anderson. The end-to-end effects of Internet path selection. In Proc. ACM SIGCOMM, 1999. [88] J. Scudder, R. Fernando , and S

  2. Laser Cladding of Ni, Nb, and Mg Alloys for Improved Environmental Resistance at High Temperature

    DTIC Science & Technology

    1989-01-01

    formation in the case of alloy AZ91 B. The anodic current density is 1.32 A/cm2 which is muchI larger than that of the laser claddings. As the potential is...Loq I A/cm2 Fig. 19 Potentiodynamic anodic polarization test of Mg alloy, AZ91 B. 37 region and the substrate. This could be attributed to the epitaxial

  3. BJUT at TREC 2015 Contextual Suggestion Track

    DTIC Science & Technology

    2015-11-20

    of Technology, Beijing 100124, China 2. Beijing Key Laboratory of Trusted Computing, Beijing 100124, China 3. National Engineering Laboratory for...CTISCP, Beijing 100124, China ⇤yangzhen@bjut.edu.cn Abstract In this paper we described our efforts for TREC contextual suggestion task. Our goal of this...Exploiting homophily effect for trust prediction. In Proceedings of the sixth ACM international conference on Web search and data mining , pages 53–62. ACM

  4. Networking Foundations for Collaborative Computing at Internet Scope

    DTIC Science & Technology

    2006-01-01

    IEEE Journal on Selected Areas in Communica- tions, 15(3):567–575, April 1997. [15] C . Greenhalgh and S . Benford. MASSIVE: A collaborative virtual...undoing actions in collaborative systems. ACM Trans. Computer- Human Interaction, 1(4):295–330, Dec. 1994. [24] S . Rajan, P. V. Rangan , and H. M. Vin...1992. [35] H. M. Vin, P. V. Rangan , and S . Ramanathan. Hierarchical conferencing architectures for inter-group multimedia col- laboration. In ACM

  5. Hardware Support for Malware Defense and End-to-End Trust

    DTIC Science & Technology

    2017-02-01

    10 Figure 4 Design flow of ACM Bluespec FPGA model ................................................................ 11 Figure 5 ACM concept...may be insufficient for continuation of trust at an arbitrary point in the future. If the design of the system permits undetectable attacks against...formed IoT division, and with selected partners.  Standards: “Trust Dust”, the early prototype of the value of embedded TPM for cyber- physical systems

  6. Modeling and Performance Evaluation of Backoff Misbehaving Nodes in CSMA/CA Networks

    DTIC Science & Technology

    2012-08-01

    range of backoff misbehaviors on network performance in CSMA/CA-based wireless networks. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17...Layer Misbeha- vior in Wireless Networks,” ACM Trans. Information and Systems Security , vol. 11, no. 4, pp. 19:1-19:28, July 2008. [10] S. Choi, K...Park, and C. kwon Kim, “On the Performance Characteristics of WLANs : Revisited,” Proc. ACM SIGMETRICS Int’l Conf. Measurement and Modeling of Computer

  7. Effective Task Assignment and Motion Planning for Complex UAV Operations

    DTIC Science & Technology

    2011-09-01

    the eighth annual ACM symposium on Theory of computing , STOC ’76, ACM, New York, NY, USA, 1976, pp. 10–22. [15] Papadimitriou , C. H., “The Euclidean...AFRL-AFOSR-UK-TR-2011-0038 Effective Task Assignment and Motion Planning for Complex UAV Operations Tal Y. Shima...Planning for Complex UAV Operations 5a. CONTRACT NUMBER FA8655-09-1-3066 5b. GRANT NUMBER Grant 09-3066 5c. PROGRAM ELEMENT NUMBER 6

  8. Destruction and Vitrification of Asbestos Using Plasma Arc Technology (Construction Productivity Advancement Research (CPAR) Program)

    DTIC Science & Technology

    1993-09-01

    economic viability of ACM vitrification processes based on conventional technologies. Existing ACM vitrification processes generally require one or more of...asbestos using plasma arc technology, the economic viability of the process must be proven if the process is to be commercialized. Three areas must...disposal costs for the purpose of evaluating the economic viability of this plasma arc destruction and vitrification process. b. Projected Cost of

  9. Stochastic Quantitative Reasoning for Autonomous Mission Planning

    DTIC Science & Technology

    2014-04-09

    Specifications.!In!3rd+ACM+ SIGSPATIAL+International+Workshop+on+ Querying +and+Mining+Uncertain+ Spatio@Temporal+ Data +(QUeST)+2012,!Redondo!Beach,!California...ACM+ SIGSPATIAL+International+Workshop+on+ Querying +and+Mining+Uncertain+ Spatio@Temporal+ Data +(QUeST)+2012,!Redondo!Beach,!California,!USA,! November...to develop self-healing spatio-temporal data stream systems, we have developed a highly declarative program- ming language called PILOTS that enables

  10. Constraint-Based Integration of Geospatial and Online Sources

    DTIC Science & Technology

    2007-09-10

    sources to accurately geocode addresses. In Proceedings of the 12th ACM International Symposium on Advances in Geographic Information Systems (ACM- GIS 󈧈...34* Rahul Bakshi Integration and reasoning about online sources to accurately geocode addresses. Master’s thesis, University of Southern California...2004. Rahul Bakshi. Integration and reasoning about online sources to accurately geocode addresses. Master’s thesis, University of Southern

  11. Energy-Efficient, Utility Accrual Scheduling under Resource Constraints for Mobile Embedded Systems

    DTIC Science & Technology

    2004-01-01

    scaling (DVS) is a common mecha- nism studied in the past to save CPU energy [5, 12, 14, 15, 25, 30, 31, 37]. DVS addresses the trade-off between...hence enables a lower voltage and yields a quadratic energy reduction, at the expense of roughly lin- 2004 ACM International Conference on Embedded...Consumption 2004 ACM International Conference on Embedded Software Most of the past work on energy-efficient real-time schedul- ing using DVS only considers the

  12. Mineralogical conversion of asbestos containing materials

    SciTech Connect

    Pulsford, S.K.; Foltz, A.D.; Ek, R.B.

    1996-12-31

    The principal objective of the Technical Task Plan (TTP) is to demonstrate a thermal-chemical mineralogical asbestos conversion unit at the Hanford Site, which converts non-radiological asbestos containing materials (ACMs) into an asbestos-free material. The permanent thermal-chemical mineralogical conversion of ACMs to a non-toxic, non-hazardous, potentially marketable end product should not only significantly reduce the waste stream volumes but terminate the {open_quotes}cradle to grave{close_quotes} ownership liabilities.

  13. Balancing Kinetic Effects of Airpower with Counterinsurgency Objectives in Afghanistan

    DTIC Science & Technology

    2009-01-29

    challenges for other elements of joint fire support, kinetic effects from the air component is particularly important to support operations. Anti ...important to support operations. Anti -Coalition Militants (ACM) are unable to negate the effects of kinetic airpower via direct means and have turned to...High Value Individual (HVI). Intelligence reports indicated that 20-30 Anti -Coalition Militant (ACM) fighters were holding a Shura2 in the village of

  14. An Intelligent Mathematical Modelling System - Mathmodel

    DTIC Science & Technology

    1989-03-31

    systems in cost and rsuisite expertise. 20. DISTRIBUTION /AVAILABILITY OF ABSTRACT 21. ABSTRA T SECU"Y ASSIFICATION MUNCLASSIFIED/UNLIMITED 0 SAME AS RPT...34 Allyn and Bacon, Inc., 1986. 39. M. Shaw and W.A. Wulf, " Abstraction And Verification in ALPHARD: Defining and Specifying Iteration and Generators...44. R.C. Waters, " Expressional Loops," Proc. 10th ACM Symposium Principles of Programming Languages, pp. 1-10, ACM, 1983. 45. R.C. Waters, "A Melhod

  15. ML Partial Evaluation Using Set-Based Analysis

    DTIC Science & Technology

    1994-02-01

    Copenhagen, May 15-18, 1990. 7 [51 Charles Consel . Binding time analysis for higher order untyped functional languages. In Mitchell Wand, editor...Proceedings of the 1990 ACM Confer- ence on Lisp and Functional Programming, pages 264-272, Nice, Friace, June 1990. ACM Press. [61 Charles Consel . A tour of...Schism: A partial evaluation system for higher- order applicative languages. In Schmidt [ 171, pages 145-154. [71 Charles Consel and Olivier Danvy

  16. Detecting and Jamming Dynamic Communication Networks in Anti-Access Environments

    DTIC Science & Technology

    2011-03-01

    2006. ACM. [30] Chen Wang and Li Xiao. Sensor localization in concave environments. ACM Trans. Sen. Netw., 4(1): 1-31. 2008. [31] Kui Wu, Yong Gao...Chong Liu, Jianping Pan, and Dandan Huang . Robust range-free localization in wireless sensor net- works. Mob. Netw. Appl., 12(5):392-405. 2007. [33...sensor network survey. Comput. Netw., 52(12):2292-2330,2008. [37] Yong Yuan, Zongkai Yang, Min Chen, and Jianhua He. A survey on information

  17. Modular Machine Code Verification

    DTIC Science & Technology

    2007-05-01

    assembly level program verification is to design a type system for assembly language. Partly inspired by the Typed Intermediate Language (TIL) [57... designed to support direct verification of assembly programs with non-trivial 126 properties not expressible in traditional types. Besides the examples...provably sound tal for back-end opti- mization. In Proc. 2003 ACM Conference on Programming Language Design and Imple- mentation, pages 208–219. ACM

  18. A Type System For Certified Runtime Type Analysis

    DTIC Science & Technology

    2002-12-01

    some features designed for program extraction [Pau89] which are not required in our case (where proofs are only used as specifications for the...flint.cs.yale.edu. [MSS01] Stefan Monnier, Bratin Saha, and Zhong Shao. Principled scavenging. In Proc. 2001 ACM SIGPLAN Programming Language Design and...and Mark P. Jones. Implementing type classes. In Programming Language Design and Implementation, New York, 1993. ACM Press. [PL89] Frank Pfenning and

  19. Design and Implementation of Code Optimizations for a Type-Directed Compiler for Standard ML.

    DTIC Science & Technology

    1996-12-01

    how programs are written, the reliability of programs , and the scale of programs that can be written. A poorly- designed programming language, such as...never quite work right. A well- designed programming language, such as SML, on the other hand makes it a joy to program . For too long, most of the world...Orlando, FL, January 1991. ACM. [2] Proceedings of the ACM SIGPLAN 󈨡 Conference on Programming Language Design and Implementation, Albuquerque, New

  20. Typing First-Class Continuations in ML

    DTIC Science & Technology

    1990-10-01

    Evans. PAL - a language designed for teaching programming linguistics. In Proc. ACM 23rd National Conference, pages 395-403, Princeton, 1968. ACM...in Scheme is considered. A number of alternative type systems are discussed, and several programming examples are given. The semantics of type...continuations.functional programming 1 Introduction First-class continuations are a simple and natural way to provide access to the flow of evaluation

  1. TIL: A Type-Directed Optimizing Compiler for ML.

    DTIC Science & Technology

    1996-02-29

    Conference on Program - ming Language Design and Implementation, Philadelphia, Pennsylvania, May 21-24, 1996. It is also published as Fox Memorandum...Conference on Programming Language Design and Implementation, pages 85-94, Atlanta, Georgia, June 1988. ACM. [14] A. Demers, M. Weiser, B. Hayes, H...on Programming Language Design and Implementation, pages 273-282, San Francisco, CA, June 1992. ACM. [16] Amer Diwan, David Tarditi, and Eliot Moss

  2. A Type-Preserving Compiler Infrastructure

    DTIC Science & Technology

    2002-12-01

    I do not make any particular claims about the merits of object-oriented program - ming, analysis, or design . It is clear, however, that objects...Mobile-Code Representation Based on Static Single Assignment Form.” Proc. Conf. on Programming Language Design and Im- plementation. ACM. Appel, Andrew...Functional Programming . ACM, Paris, 126–137. 123 124 Bibliography Booch, Grady. 1994. Object-Oriented Analysis and Design , with Applications. 2nd edi- tion

  3. Composite Social Network for Predicting Mobile Apps Installation

    DTIC Science & Technology

    2011-06-02

    Gatica-Perez 2010] Farrahi, K., and Gatica- Perez, D. 2010. Probabilistic Mining of Socio-Geographic Routines From Mobile Phone Data . Selected Topics in...discovery and data mining , 1019–1028. ACM. [Granovetter and Soong 1983] Granovetter, M., and Soong, R. 1983. Threshold models of diffusion and...discovery and data mining , 137–146. ACM. [Leskovec, Adamic, and Huberman 2007] Leskovec, J.; Adamic, L.; and Huberman, B. 2007. The dynamics of viral

  4. Theoretical and experimental analysis of amplitude control ablation and bipolar ablation in creating linear lesion and discrete lesions for treating atrial fibrillation.

    PubMed

    Yan, Shengjie; Wu, Xiaomei; Wang, Weiqi

    2017-09-01

    Radiofrequency (RF) energy is often used to create a linear lesion or discrete lesions for blocking the accessory conduction pathways for treating atrial fibrillation. By using finite element analysis, we study the ablation effect of amplitude control ablation mode (AcM) and bipolar ablation mode (BiM) in creating a linear lesion and discrete lesions in a 5-mm-thick atrial wall; particularly, the characteristic of lesion shape has been investigated in amplitude control ablation. Computer models of multipolar catheter were developed to study the lesion dimensions in atrial walls created through AcM, BiM and special electrodes activated ablation methods in AcM and BiM. To validate the theoretical results in this study, an in vitro experiment with porcine cardiac tissue was performed. At 40 V/20 V root mean squared (RMS) of the RF voltage for AcM, the continuous and transmural lesion was created by AcM-15s, AcM-5s and AcM-ad-20V ablation in 5-mm-thick atrial wall. At 20 V RMS for BiM, the continuous but not transmural lesion was created. AcM ablation yielded asymmetrical and discrete lesions shape, whereas the lesion shape turned to more symmetrical and continuous as the electrodes alternative activated period decreased from 15 s to 5 s. Two discrete lesions were created when using AcM, AcM-ad-40V, BiM-ad-20V and BiM-ad-40V. The experimental and computational thermal lesion shapes created in cardiac tissue were in agreement. Amplitude control ablation technology and bipolar ablation technology are feasible methods to create continuous lesion or discrete for pulmonary veins isolation.

  5. Protocol Programmability

    DTIC Science & Technology

    2013-12-01

    Michael Maass, Ligia Nistor, Larry Maccherone, Cyrus Omar, Ivan Ruchkin, Jason Tsay, and YoungSeok Yoon. Thank you to former students and post-docs... Baumgartner , and Michal Young. Compiler and tool support for debugging object protocols. In Proceedings of the 8th ACM SIGSOFT International Symposium...ACM. 2.1 Michael Hoppe and Stefan Hanenberg. Do developers benefit from generic types?: An empirical comparison of generic and raw types in java. In

  6. ICTNET at Microblog Track in TREC 2014

    DTIC Science & Technology

    2014-11-01

    International Conference on Knowledge Discovery and Data Mining , 2006. [5] Jinhua Gao, Guoxin Cui, Shenghua Liu, Yue Liu and Xueqi Cheng. ICTNET at...comparative text mining [C]//Proceedings of the tenth ACM SIGKDD international conference on Knowledge discovery and data mining . ACM, 2004: 743-748...1)Institute of Computing Technology, Chinese Academy of Sciences, Beijing, 100190 2)Key Laboratory of Web Data Science and Technology,CAS,100190 3

  7. Adaptive Statistical Language Modeling; A Maximum Entropy Approach

    DTIC Science & Technology

    1994-04-19

    ACCUSE] ACCUSE, ACCUSED, ACCUSES, ACCUSING [ACCUSTOM] : ACCUSTOMED [ ACCUTANE ] ACCUTANE [ACE] :ACE [ACHIEVE] : ACHIEVE, ACHIEVED, ACHIEVES, ACHIEVING...Appendix C. Best Triggers by the MI-3g Measure ACCUSING 4= FILED COURT ACCUTANE 4- ACCUTANE ACNE DEFECTS HOFFMANN ROCHE BIRTH DRUG’S DRUG PREG- NANT...TOP GOING INDUSTRY PRESIDENT WANT OFTEN LOT OWN TOO WHERE ACME = ACME STEEL ACNE = ACNE RETIN DRUG ACCUTANE HOFFMANN ROCHE PRESCRIPTION DRUG’S SKIN

  8. Ciliary neurotrophic factor-treated astrocyte-conditioned medium increases the intracellular free calcium concentration in rat cortical neurons

    PubMed Central

    SUN, MEIQUN; LIU, HONGLI; MIN, SHENGPING; WANG, HONGTAO; WANG, XIAOJING

    2016-01-01

    Ciliary neurotrophic factor (CNTF) is involved in the activation of astrocytes. A previous study showed that CNTF-treated astrocyte-conditioned medium (CNTF-ACM) contributed to the increase of the calcium current and the elevation of corresponding ion channels in cortical neurons. On this basis, it is reasonable to assume that CNTF-ACM may increase the intracellular free calcium concentration ([Ca2+]i) in neurons. In the present study, the effects of CNTF-ACM on [Ca2+]i in rat cortical neurons were determined, and on this basis, the aim was to investigate the potential active ingredients in ACM that are responsible for this biological process. As expected, the data indicated that CNTF-ACM resulted in a clear elevation of [Ca2+]i in neurons. Additionally, the fibroblast growth factor-2 (FGF-2) contained in the CNTF-ACM was found to participate in the upregulation of [Ca2+]i. Taken together, CNTF induces the production of active factors (at least including FGF-2) released from astrocytes, which finally potentiate the increase of [Ca2+]i in cortical neurons. PMID:27073624

  9. Requirement of Autolytic Activity for Bacteriocin-Induced Lysis

    PubMed Central

    Martínez-Cuesta, M. Carmen; Kok, Jan; Herranz, Elisabet; Peláez, Carmen; Requena, Teresa; Buist, Girbe

    2000-01-01

    The bacteriocin produced by Lactococcus lactis IFPL105 is bactericidal against several Lactococcus and Lactobacillus strains. Addition of the bacteriocin to exponential-growth-phase cells resulted in all cases in bacteriolysis. The bacteriolytic response of the strains was not related to differences in sensitivity to the bacteriocin and was strongly reduced in the presence of autolysin inhibitors (Co2+ and sodium dodecyl sulfate). When L. lactis MG1363 and its derivative deficient in the production of the major autolysin AcmA (MG1363acmAΔ1) were incubated with the bacteriocin, the latter did not lyse and no intracellular proteins were released into the medium. Incubation of cell wall fragments of L. lactis MG1363, or of L. lactis MG1363acmAΔ1 to which extracellular AcmA was added, in the presence or absence of the bacteriocin had no effect on the speed of cell wall degradation. This result indicates that the bacteriocin does not degrade cell walls, nor does it directly activate the autolysin AcmA. The autolysin was also responsible for the observed lysis of L. lactis MG1363 cells during incubation with nisin or the mixture of lactococcins A, B, and M. The results presented here show that lysis of L. lactis after addition of the bacteriocins is caused by the resulting cell damage, which promotes uncontrolled degradation of the cell walls by AcmA. PMID:10919766

  10. An international observational study suggests that artificial intelligence for clinical decision support optimizes anemia management in hemodialysis patients.

    PubMed

    Barbieri, Carlo; Molina, Manuel; Ponce, Pedro; Tothova, Monika; Cattinelli, Isabella; Ion Titapiccolo, Jasmine; Mari, Flavio; Amato, Claudia; Leipold, Frank; Wehmeyer, Wolfgang; Stuard, Stefano; Stopper, Andrea; Canaud, Bernard

    2016-08-01

    Managing anemia in hemodialysis patients can be challenging because of competing therapeutic targets and individual variability. Because therapy recommendations provided by a decision support system can benefit both patients and doctors, we evaluated the impact of an artificial intelligence decision support system, the Anemia Control Model (ACM), on anemia outcomes. Based on patient profiles, the ACM was built to recommend suitable erythropoietic-stimulating agent doses. Our retrospective study consisted of a 12-month control phase (standard anemia care), followed by a 12-month observation phase (ACM-guided care) encompassing 752 patients undergoing hemodialysis therapy in 3 NephroCare clinics located in separate countries. The percentage of hemoglobin values on target, the median darbepoetin dose, and individual hemoglobin fluctuation (estimated from the intrapatient hemoglobin standard deviation) were deemed primary outcomes. In the observation phase, median darbepoetin consumption significantly decreased from 0.63 to 0.46 μg/kg/month, whereas on-target hemoglobin values significantly increased from 70.6% to 76.6%, reaching 83.2% when the ACM suggestions were implemented. Moreover, ACM introduction led to a significant decrease in hemoglobin fluctuation (intrapatient standard deviation decreased from 0.95 g/dl to 0.83 g/dl). Thus, ACM support helped improve anemia outcomes of hemodialysis patients, minimizing erythropoietic-stimulating agent use with the potential to reduce the cost of treatment. Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  11. Heartwood extract of Acacia catechu induces apoptosis in human breast carcinoma by altering bax/bcl-2 ratio

    PubMed Central

    Ghate, Nikhil Baban; Hazra, Bibhabasu; Sarkar, Rhitajit; Mandal, Nripendranath

    2014-01-01

    Background: The heartwood extract of A. catechu, called pale catechu or “Katha” in Hindi has been widely used in traditional Indian medicinal system. Although various pharmacological properties of this plant had been reported previously, only a few were concerned with the anticancer activity of this plant. Objective: The objective was to assess the in vitro anticancer and apoptosis inducing effect of 70% methanolic extract of “Katha” (ACME) on human breast adenocarcinoma cell line (MCF-7). Materials and Methods: MCF-7 cell line was treated with increasing concentrations of ACME and cell viability was calculated. Flow cytometric methods were used to confirm the apoptosis promoting role of ACME. Morphological changes were then analysed using confocal microscopy. Western blotting was then performed to investigate the expression of apoptogenic proteins and to analyse the activation of caspases. Results: ACME showed significant cytotoxicity to MCF-7 cells with an IC50 value of 288.85 ± 25.79 μg/ml. Flow cytometric analysis and morphological studies confirmed that ACME is able to induce apoptosis in MCF-7 cells. Furthermore, immunoblot results suggested the pathway of apoptosis induction by increasing Bax/Bcl-2 ratio which results in the activation of caspase-cascade and ultimately leads to the cleavage of Poly adeno ribose polymerase (PARP). Conclusion: These results provide the evidence that ACME is able to inhibit the proliferation of MCF-7 cells by inducing apoptosis through intrinsic pathway. PMID:24695415

  12. Amphiphilic carbonaceous material-intervened solvothermal synthesis of LiFePO4

    NASA Astrophysics Data System (ADS)

    Chen, Ming-ming; Ma, Qian-qian; Wang, Cheng-yang; Sun, Xin; Wang, Li-qun; Zhang, Cui

    2014-10-01

    LiFePO4 samples with preferred facets on the ac plane were prepared by the solvothermal method with or without well-dispersed amphiphilic carbonaceous material (ACM). The effects of ACM on the particle morphology, crystal orientation and electrochemical reactivity of the prepared LiFePO4 nanoparticles were investigated in detail. ACM serves a dual purpose. One purpose is facilitating the plate-like morphologies of LiFePO4 nanoparticles parallel to the bPnma axis by decreasing the surface energy of (010) facets of newly created LiFePO4 nuclei. The other purpose is suppressing crystal growth along the [010] direction by adhering onto the (010) surface of LiFePO4 nanoplates. Furthermore, ACM coating was performed and optimized using a carbon coating precursor. The electrochemical properties of the prepared LiFePO4 particles were characterized by cyclic voltammetry (CV) and galvanostatic charge-discharge cycling tests. After the optimized coating of ACM, the ACM-intervened LiFePO4 composite was observed to deliver discharge capacities of 151.3 mAh g-1 at 1C and 132.2 mAh g-1 at 10C. Even after 1000 cycles at a high rate of 10C, the LiFePO4 cathode could maintain 80% of its initial capacity.

  13. Chronic infusion of SOD1(G93A) astrocyte-secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats.

    PubMed

    Ramírez-Jarquín, Uri N; Rojas, Fabiola; van Zundert, Brigitte; Tapia, Ricardo

    2017-01-27

    Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and studies in vitro show that motoneuron degeneration is triggered by non-cell-autonomous mechanisms. However, whether soluble toxic factor(s) released by mutant superoxide dismutase 1 (SOD1) expressing astrocytes induces death of motoneurons and leads to motor dysfunction in vivo is not known. To directly test this, healthy adult rats were treated with conditioned media derived from primary mouse astrocytes (ACM) that express human (h) SOD1(G93A) (ACM-hG93A) via chronic osmotic pump infusion in the lumbar spinal cord. Controls included ACM derived from transgenic mice expressing hSOD1(WT) (ACM-hWT) or non-transgenic mouse SOD1(WT) (ACM-WT) astrocytes. Rats chronically infused with ACM-hG93A started to develop motor dysfunction at 8 days, as measured by rotarod performance. Additionally, immunohistochemical analyses at day 16 revealed reactive astrogliosis and significant loss of motoneurons in the ventral horn of the infused region. Controls did not show significant motor behavior alterations or neuronal damage. Thus, we demonstrate that factors released in vitro from astrocytes derived from ALS mice cause spinal motoneuron death and consequent neuromuscular dysfunction in vivo.

  14. Curative effect of Amorphophallus campanulatus (Roxb.) Blume. tuber on N-nitrosodiethylamine- induced hepatocellular carcinoma in rats.

    PubMed

    Ansil, Puthuparampil Nazarudeen; Nitha, Anand; Prabha, Santhibhavan Prabhakaran; Latha, Mukalel Sankunni

    2014-01-01

    In this study, we investigated the curative effect of Amorphophallus campanulatus tuber methanolic extract (ACME) on N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma (HCC) in experimental rats. All of the rats except those in the normal control group received 0.02% NDEA orally (2 mL, 5 days/week) for the first 20 weeks of the experiment. In different treatment groups, after 20 weeks of NDEA challenge, rats were supplemented with ACME (125 and 250 mg/kg body weight, orally) for the following 28 days. In addition, a standard drug control group was supplemented with silymarin (100 mg/kg bw, orally), a known tumorsuppressive agent against HCC. Administration of ACME significantly inhibited the NDEA-induced increase of hepatic nodule incidence, nodule multiplicity, and serum biochemical indices, and improved the hepatocellular architecture in a dose-dependent manner. The biochemical analysis of hepatic tissues further demonstrated that ACME counteracts NDEA-induced oxidative stress through the restoration of antioxidant enzymes. NDEAadministered rats also showed amplified expression of proliferating cell nuclear antigen in the liver, and decreased expression of this proliferative marker was clearly observed upon the supplementation of ACME. Notably, 250 mg/kg bw ACME supplementation showed better results than the other treatment regimens; this result might be associated with the enhancement of antioxidant activity and inhibition of hepatic cell proliferation.

  15. The ARVD/C genetic variants database: 2014 update.

    PubMed

    Lazzarini, Elisabetta; Jongbloed, Jan D H; Pilichou, Kalliopi; Thiene, Gaetano; Basso, Cristina; Bikker, Hennie; Charbon, Bart; Swertz, Morris; van Tintelen, J Peter; van der Zwaag, Paul A

    2015-04-01

    Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease characterized by myocardial atrophy, fibro-fatty replacement, and a high risk of ventricular arrhythmias that lead to sudden death. In 2009, genetic data from 57 publications were collected in the arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) Genetic Variants Database (freeware available at http://www.arvcdatabase.info), which comprised 481 variants in eight ACM-associated genes. In recent years, deep genetic sequencing has increased our knowledge of the genetics of ACM, revealing a large spectrum of nucleotide variations for which pathogenicity needs to be assessed. As of April 20, 2014, we have updated the ARVD/C database into the ARVD/C database to contain more than 1,400 variants in 12 ACM-related genes (PKP2, DSP, DSC2, DSG2, JUP, TGFB3, TMEM43, LMNA, DES, TTN, PLN, CTNNA3) as reported in more than 160 references. Of these, only 411 nucleotide variants have been reported as pathogenic, whereas the significance of the other approximately 1,000 variants is still unknown. This comprehensive collection of ACM genetic data represents a valuable source of information on the spectrum of ACM-associated genes and aims to facilitate the interpretation of genetic data and genetic counseling.

  16. Effect of Artocarpus communis Extract on UVB Irradiation-Induced Oxidative Stress and Inflammation in Hairless Mice

    PubMed Central

    Lee, Chiang-Wen; Ko, Horng-Huey; Chai, Chee-Yin; Chen, Wan-Tzu; Lin, Chun-Ching; Yen, Feng-Lin

    2013-01-01

    Administration of antioxidants and anti-inflammatory agents is an effective strategy for preventing ultraviolet (UV) irradiation-induced skin damage. Artocarpus communis possesses several pharmacological activities, such as antioxidant, anticancer and anti-inflammation. However, the photoprotective activity of methanol extract of A. communis heartwood (ACM) in ultraviolet irradiation-induced skin damage has not yet been investigated. The present study was performed using ultraviolet absorption, histopathological observation, antioxidant and anti-inflammation assays to elucidate the mechanism of the photoprotective activity of ACM. Our results indicated that ACM displayed a UVA and UVB absorption effect and then effectively decreased scaly skin, epidermis thickness and sunburn cells during ultraviolet irradiation in hairless mice. ACM not only decreased ultraviolet irradiation-mediated oxidative stress, including lowering the overproduction of reactive oxygen species and lipid peroxidation (p < 0.05), but also reduced the levels of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin 1β. Additionally, ACM can decrease the synthesis of cytosolic phospholipase A2, cyclooxygenase, inducible nitric oxide synthase and vascular cell adhesion molecular-1 via inhibiting TNF-α-independent pathways (p < 0.05) in UVB-mediated inflammation and formation of sunburn cells. Consequently, we concluded that ACM extract has a photoprotective effect against UVB-induced oxidative stress and inflammation due to its sunscreen property, and its topical formulations may be developed as therapeutic and/or cosmetic products in further studies. PMID:23403620

  17. Preparation of binderless activated carbon monolith from pre-carbonization rubber wood sawdust by controlling of carbonization and activation condition

    NASA Astrophysics Data System (ADS)

    Taer, E.; Deraman, M.; Taslim, R.; Iwantono

    2013-09-01

    Binderless activated carbon monolith (ACM) was prepared from pre-carbonized rubber wood sawdust (RWSD). The effect of the carbonization temperature (400, 500, 600, 700, 800 dan 900 °C) on porosity characteristic of the ACM have been studied. The optimum carbonization temperature for obtaining ACM with high surface area of 600 °C with CO2 activation at 800 °C for one hour. At this condition, the surface area as high as 733 m2 g-1 could be successfully obtained. By improved the activation temperature at 900 °C for 2.5 h, it was found that the surface area of 860 m2 g-1. For this condition, the ACM exhibit the specific capacitance of 90 F g-1. In addition the termogravimertic (TG)-differential termografimertic (DTG) and field emission scanning electron microscope (FESEM) measurement were also performed on the ACMs and the result has been studied. Finally, it was conclude that the high surface area of ACM from RWSD could be produced by proper selections of carbonization and activation condition.

  18. In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera.

    PubMed

    Djeraba, A; Quere, P

    2000-05-01

    Acemannan (ACM 1), a beta-(1,4) -acetylated mannan isolated from Aloe vera, can be used as an effective adjuvant in vaccination against some avian viral diseases. Our results demonstrate a quick and lasting in vivo priming effect of ACM 1 on macrophage response after intramuscular inoculation in chickens (500 microg per 2-month-old bird). In response to IFN-gamma in vitro, monocytes from ACM 1-treated chickens exhibited a strong enhancement of NO production from 3 to 9 days p.i., but a weaker effect on MHC II cell surface antigen expression on day 3 p.i. A stimulating effect of ACM 1 treatment was also observed on spontaneous and inducible NO production for splenocytes only on day 3 p.i. By that time, splenocytes exhibited a strong higher capacity to proliferate in response to the T cell-mitogen PHA. At the same time, the in vivo capacity to produce NO, measured by the (NO(-)(2)+NO(-)(3)) serum level after intravenous LPS injection, increased greatly from 3 to 9 days p.i. In conclusion, ACM 1 was able efficiently and durably to increase the activation capacity of macrophages from the systemic immune compartment (in particular from the blood and spleen after an intramuscular injection) in chickens, especially for NO production. These findings provide a better understanding of the adjuvant activity of ACM 1 for viral and tumoral diseases.

  19. Self-Contained Induction of Neurons from Human Embryonic Stem Cells

    PubMed Central

    Okuno, Tsuyoshi; Nakayama, Takashi; Konishi, Nae; Michibata, Hideo; Wakimoto, Koji; Suzuki, Yutaka; Nito, Shinji; Inaba, Toshio; Nakano, Imaharu; Muramatsu, Shin-ichi; Takano, Makoto; Kondo, Yasushi; Inoue, Nobuo

    2009-01-01

    Background Neurons and glial cells can be efficiently induced from mouse embryonic stem (ES) cells in a conditioned medium collected from rat primary-cultured astrocytes (P-ACM). However, the use of rodent primary cells for clinical applications may be hampered by limited supply and risk of contamination with xeno-proteins. Methodology/Principal Findings We have developed an alternative method for unimpeded production of human neurons under xeno-free conditions. Initially, neural stem cells in sphere-like clusters were induced from human ES (hES) cells after being cultured in P-ACM under free-floating conditions. The resultant neural stem cells could circumferentially proliferate under subsequent adhesive culture, and selectively differentiate into neurons or astrocytes by changing the medium to P-ACM or G5, respectively. These hES cell-derived neurons and astrocytes could procure functions similar to those of primary cells. Interestingly, a conditioned medium obtained from the hES cell-derived astrocytes (ES-ACM) could successfully be used to substitute P-ACM for induction of neurons. Neurons made by this method could survive in mice brain after xeno-transplantation. Conclusion/Significance By inducing astrocytes from hES cells in a chemically defined medium, we could produce human neurons without the use of P-ACM. This self-serving method provides an unlimited source of human neural cells and may facilitate clinical applications of hES cells for neurological diseases. PMID:19621077

  20. Self-contained induction of neurons from human embryonic stem cells.

    PubMed

    Okuno, Tsuyoshi; Nakayama, Takashi; Konishi, Nae; Michibata, Hideo; Wakimoto, Koji; Suzuki, Yutaka; Nito, Shinji; Inaba, Toshio; Nakano, Imaharu; Muramatsu, Shin-Ichi; Takano, Makoto; Kondo, Yasushi; Inoue, Nobuo

    2009-07-21

    Neurons and glial cells can be efficiently induced from mouse embryonic stem (ES) cells in a conditioned medium collected from rat primary-cultured astrocytes (P-ACM). However, the use of rodent primary cells for clinical applications may be hampered by limited supply and risk of contamination with xeno-proteins. We have developed an alternative method for unimpeded production of human neurons under xeno-free conditions. Initially, neural stem cells in sphere-like clusters were induced from human ES (hES) cells after being cultured in P-ACM under free-floating conditions. The resultant neural stem cells could circumferentially proliferate under subsequent adhesive culture, and selectively differentiate into neurons or astrocytes by changing the medium to P-ACM or G5, respectively. These hES cell-derived neurons and astrocytes could procure functions similar to those of primary cells. Interestingly, a conditioned medium obtained from the hES cell-derived astrocytes (ES-ACM) could successfully be used to substitute P-ACM for induction of neurons. Neurons made by this method could survive in mice brain after xeno-transplantation. By inducing astrocytes from hES cells in a chemically defined medium, we could produce human neurons without the use of P-ACM. This self-serving method provides an unlimited source of human neural cells and may facilitate clinical applications of hES cells for neurological diseases.

  1. Knowledge and use of asthma control measurement tools in the management of asthma: a survey of doctors working in family and internal medicine practice in Nigeria.

    PubMed

    Desalu, Olufemi Olumuyiwa; Onyedum, Cajetan C; Adeoti, Adekunle O; Ozoh, Obianuju B; Fadare, Joseph O

    2016-06-01

    To investigate the knowledge and use of asthma control measurement (ACM) tools in the management of asthma among doctors working in family and internal medicine practice in Nigeria. A questionnaire based on the global initiative on asthma (GINA) guideline was self-administered by 194 doctors. It contains 12 test items on knowledge of ACM tools and its application. The knowledge score was obtained by adding the correct answers and classified as good if the score ≥ 9, satisfactory if score was 6-8 and poor if < 6. The overall doctors knowledge score of ACM tools was 4.49±2.14 (maximum of 12). Pulmonologists recorded the highest knowledge score of 10.75±1.85. The majority (69.6%) had poor knowledge score of ACM tools. Fifty (25.8%) assessed their patients' level of asthma control and 34(17.5%) at every visit. Thirty-nine (20.1%) used ACM tools in their consultation, 29 (15.0%) of them used GINA defined control while 10 (5.2 %) used asthma control test (ACT). The use of the tools was associated with pulmonologists, having attended CME within six months and graduated within five years prior to the survey. The results highlight the poor knowledge and use of ACM tools and the need to address the knowledge gap.

  2. Effects of discontinuation of long-term anticholinergic treatment in elderly schizophrenia patients.

    PubMed

    Drimer, T; Shahal, B; Barak, Y

    2004-01-01

    Anticholinergic medication (ACM) is frequently used in psychiatry to treat the side-effects of D2 blocking agents. However, ACM is not without adverse effects and, in the elderly, cognitive and memory impairments have been emphasized. The aim of this study was to evaluate the effects of discontinuation of ACM on cognitive functions in a group of elderly chronic schizophrenia patients. Twenty-seven elderly patients (age 60 years or older), who were diagnosed as suffering from schizophrenia (DSM-IV) and receiving ACM in addition to antipsychotic treatment, were enrolled. Before and after ACM was discontinued, the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) subscale was administered. Twenty-one patients completed the study. All were receiving Akineton (biperiden), 2-6 mg daily before the study. Significant improvement in the ADAS-Cog total score was demonstrated (P < 0.03), as well as in the ideational praxia and orientation subscales. Improvement was correlated with the previous dose of biperidin. No adverse events or emergent extrapyramidal symptoms were noted. Discontinuation of ACM may be warranted in chronic schizophrenia patients since it may improve cognitive functioning with no adverse effects.

  3. Antibody Colocalization Microarray: A Scalable Technology for Multiplex Protein Analysis in Complex Samples*

    PubMed Central

    Pla-Roca, M.; Leulmi, R. F.; Tourekhanova, S.; Bergeron, S.; Laforte, V.; Moreau, E.; Gosline, S. J. C.; Bertos, N.; Hallett, M.; Park, M.; Juncker, D.

    2012-01-01

    DNA microarrays were rapidly scaled up from 256 to 6.5 million targets, and although antibody microarrays were proposed earlier, sensitive multiplex sandwich assays have only been scaled up to a few tens of targets. Cross-reactivity, arising because detection antibodies are mixed, is a known weakness of multiplex sandwich assays that is mitigated by lengthy optimization. Here, we introduce (1) vulnerability as a metric for assays. The vulnerability of multiplex sandwich assays to cross-reactivity increases quadratically with the number of targets, and together with experimental results, substantiates that scaling up of multiplex sandwich assays is unfeasible. We propose (2) a novel concept for multiplexing without mixing named antibody colocalization microarray (ACM). In ACMs, both capture and detection antibodies are physically colocalized by spotting to the same two-dimensional coordinate. Following spotting of the capture antibodies, the chip is removed from the arrayer, incubated with the sample, placed back onto the arrayer and then spotted with the detection antibodies. ACMs with up to 50 targets were produced, along with a binding curve for each protein. The ACM was validated by comparing it to ELISA and to a small-scale, conventional multiplex sandwich assay (MSA). Using ACMs, proteins in the serum of breast cancer patients and healthy controls were quantified, and six candidate biomarkers identified. Our results indicate that ACMs are sensitive, robust, and scalable. PMID:22171321

  4. Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity.

    PubMed

    Lyksborg, Mark; Siebner, Hartwig R; Sørensen, Per S; Blinkenberg, Morten; Parker, Geoff J M; Dogonowski, Anne-Marie; Garde, Ellen; Larsen, Rasmus; Dyrby, Tim B

    2014-01-01

    Multiple sclerosis (MS) damages central white matter pathways which has considerable impact on disease-related disability. To identify disease-related alterations in anatomical connectivity, 34 patients (19 with relapsing remitting MS (RR-MS), 15 with secondary progressive MS (SP-MS) and 20 healthy subjects underwent diffusion magnetic resonance imaging (dMRI) of the brain. Based on the dMRI, anatomical connectivity mapping (ACM) yielded a voxel-based metric reflecting the connectivity shared between each individual voxel and all other brain voxels. To avoid biases caused by inter-individual brain-shape differences, they were estimated in a spatially normalized space. Voxel-based statistical analyses using ACM were compared with analyses based on the localized microstructural indices of fractional anisotropy (FA). In both RR-MS and SP-MS patients, considerable portions of the motor-related white matter revealed decreases in ACM and FA when compared with healthy subjects. Patients with SP-MS exhibited reduced ACM values relative to RR-MS in the motor-related tracts, whereas there were no consistent decreases in FA between SP-MS and RR-MS patients. Regional ACM statistics exhibited moderate correlation with clinical disability as reflected by the expanded disability status scale (EDSS). The correlation between these statistics and EDSS was either similar to or stronger than the correlation between FA statistics and the EDSS. Together, the results reveal an improved relationship between ACM, the clinical phenotype, and impairment. This highlights the potential of the ACM connectivity indices to be used as a marker which can identify disease related-alterations due to MS which may not be seen using localized microstructural indices.

  5. Cost-benefit analysis of avian influenza control in Nepal.

    PubMed

    Karki, S; Lupiani, B; Budke, C M; Karki, N P S; Rushton, J; Ivanek, R

    2015-12-01

    Numerous outbreaks of highly pathogenic avian influenza A strain H5N1 have occurred in Nepal since 2009 despite implementation of a national programme to control the disease through surveillance and culling of infected poultry flocks. The objective of the study was to use cost-benefit analysis to compare the current control programme (CCP) with the possible alternatives of: i) no intervention (i.e., absence of control measures [ACM]) and ii) vaccinating 60% of the national poultry flock twice a year. In terms of the benefit-cost ratio, findings indicate a return of US $1.94 for every dollar spent in the CCP compared with ACM. The net present value of the CCP versus ACM, i.e., the amount of money saved by implementing the CCP rather than ACM, is US $861,507 (the benefits of CCP [prevented losses which would have occurred under ACM] minus the cost of CCP). The vaccination programme yields a return of US $2.32 for every dollar spent when compared with the CCR The net present value of vaccination versus the CCP is approximately US $12 million. Sensitivity analysis indicated thatthe findings were robust to different rates of discounting, whereas results were sensitive to the assumed market loss and the number of birds affected in the outbreaks under the ACM and vaccination options. Overall, the findings of the study indicate that the CCP is economically superior to ACM, but that vaccination could give greater economic returns and may be a better control strategy. Future research should be directed towards evaluating the financial feasibility and social acceptability of the CCP and of vaccination, with an emphasis on evaluating market reaction to the presence of H5N1 infection in the country.

  6. Crystallization of bifonazole and acetaminophen within the matrix of semicrystalline, PEO-PPO-PEO triblock copolymers.

    PubMed

    Chen, Zhen; Liu, Zhengsheng; Qian, Feng

    2015-02-02

    The morphology and microstructure of crystalline drug/polymer solid dispersions could influence their physical stability and dissolution performance. In this study, the drug crystallization mechanism within PEG, PPG, and poloxamer matrix was investigated, and the resultant microstructure of various solid dispersions of acetaminophen (ACM) and bifonazole (BFZ) in the aforementioned polymers was characterized by differential scanning calorimetry (DSC), polarized optical microscopy (POM), and wide/small-angle X-ray diffraction (WAXD/SAXS). With a stronger molecular interaction with the PEG segments, ACM decreased the crystallization onset temperature and crystallinity of PEG and poloxamers much more than BFZ. The stronger molecular interaction and better miscibility between ACM and PEG also induced a more defective lamellar structure in the ACM solid dispersions compared with that in the BFZ systems, as revealed by DSC and SAXS investigation. Observed under polarized optical microscopy, PEG, PPG, and poloxamer could all significantly improve the crystallization rate of ACM and BFZ, because of the largely reduced Tg of the solid dispersions by these low Tg polymers. Moreover, when the drug loading was below 60%, crystallization of BFZ in PEG or poloxamer occurred preferably along the radial direction of PEG spherulite, rather than the perpendicular direction, which was attributed to the geometric restriction of well-ordered polymer lamellar structure in the BFZ solid dispersions. Similar phenomena were not observed in the ACM solid dispersions regardless of the drug loading, presumably because ACM could diffuse freely across the perpendicular direction of the PEG spherulite, through the well-connected interlamellar or interfibrillar spaces produced by the defective PEG lamellar structure. The different drug-polymer interaction also caused a difference in the microstructure of polymer crystal, as well as a difference in drug distribution within the polymer matrix, which

  7. Secondary Progressive and Relapsing Remitting Multiple Sclerosis Leads to Motor-Related Decreased Anatomical Connectivity

    PubMed Central

    Lyksborg, Mark; Siebner, Hartwig R.; Sørensen, Per S.; Blinkenberg, Morten; Parker, Geoff J. M.; Dogonowski, Anne-Marie; Garde, Ellen; Larsen, Rasmus; Dyrby, Tim B.

    2014-01-01

    Multiple sclerosis (MS) damages central white matter pathways which has considerable impact on disease-related disability. To identify disease-related alterations in anatomical connectivity, 34 patients (19 with relapsing remitting MS (RR-MS), 15 with secondary progressive MS (SP-MS) and 20 healthy subjects underwent diffusion magnetic resonance imaging (dMRI) of the brain. Based on the dMRI, anatomical connectivity mapping (ACM) yielded a voxel-based metric reflecting the connectivity shared between each individual voxel and all other brain voxels. To avoid biases caused by inter-individual brain-shape differences, they were estimated in a spatially normalized space. Voxel-based statistical analyses using ACM were compared with analyses based on the localized microstructural indices of fractional anisotropy (FA). In both RR-MS and SP-MS patients, considerable portions of the motor-related white matter revealed decreases in ACM and FA when compared with healthy subjects. Patients with SP-MS exhibited reduced ACM values relative to RR-MS in the motor-related tracts, whereas there were no consistent decreases in FA between SP-MS and RR-MS patients. Regional ACM statistics exhibited moderate correlation with clinical disability as reflected by the expanded disability status scale (EDSS). The correlation between these statistics and EDSS was either similar to or stronger than the correlation between FA statistics and the EDSS. Together, the results reveal an improved relationship between ACM, the clinical phenotype, and impairment. This highlights the potential of the ACM connectivity indices to be used as a marker which can identify disease related-alterations due to MS which may not be seen using localized microstructural indices. PMID:24748023

  8. Chemopreventive effect of Amorphophallus campanulatus (Roxb.) blume tuber against aberrant crypt foci and cell proliferation in 1, 2-dimethylhydrazine induced colon carcinogenesis.

    PubMed

    Ansil, Puthuparampil Nazarudeen; Prabha, Santhibhavan Prabhakaran; Nitha, Anand; Latha, Mukalel Sankunni

    2013-01-01

    Colorectal cancer is one of the leading causes of cancer death, both in men and women. This study investigated the effects of Amorphophallus campanulatus tuber methanolic extract (ACME) on aberrant crypt foci (ACF) formation, colonic cell proliferation, lipid peroxidative damage and the antioxidant status in a long term preclinical model of 1, 2-dimethylhydrazine (DMH) induced colon carcinogenesis in rats. Male Wistar rats were divided into six groups, viz., group I rats served as controls; group II rats treated as drug controls receiving 250 mg/ kg body weight of ACME orally; group III rats received DMH (20 mg/kg body weight) subcutaneously once a week for the first 15 weeks; groups IV, V and VI rats received ACME along with DMH during the initiation, post- initiation stages and the entire period of the study, respectively. All the rats were sacrificed at the end of 30 weeks and the intestinal and colonic tissues from different groups were subjected to biochemical and histological studies. Administration of DMH resulted in significant (p ≤ 0.05) intestinal and colonic lipid peroxidation (MDA) and reduction of antioxidants such as catalase, glutathione peroxidase, glutathione reductase, glutathione-S- transferase and reduced glutathione. Whereas the supplementation of ACME significantly (p ≤ 0.05) improved the intestinal and colonic MDA and reduced glutathione levels and the activities of antioxidant enzymes in DMH intoxicated rats. ACME administration also significantly suppressed the formation and multiplicity of ACF. In addition, the DMH administered rats showed amplified expression of PCNA in the colon and decreased expression of this proliferative marker was clearly noted with initiation, post-initiation and entire period of ACME treatment regimens. These results indicate that ACME could exert a significant chemopreventive effect on colon carcinogenesis induced by DMH.

  9. Sensitivity of WRF model estimates to various PBL parameterizations in different climatic zones over India

    NASA Astrophysics Data System (ADS)

    Gunwani, Preeti; Mohan, Manju

    2017-09-01

    In the present work sensitivity of Weather Research Forecasting (WRF) Model has been carried out using five planetary boundary layer (PBL) schemes - Yonsei University Scheme (YSU), Mellor-Yamada-Janjić scheme (MYJ), Aymmetric Convective Model version 2 (ACM2), Quasi Normal Scale Elimination scheme (QNSE), Mellor-Yamada-Nakanishi-Niino scheme (MYNN) in different climatic zones over India namely Tropical, Temperate and Arid for surface meteorological parameters, upper air variables and planetary boundary layer height during summer and winter season. The model outputs have been compared with observations through standard statistical measures. The aim is to study the relative performance of these schemes, selecting the best option climatic zone-wise and thereby minimizing uncertainty in model predictions. WRF model performance evaluation shows better agreement for temperature and relative humidity compared to wind speed. Overall for India, ACM2, QNSE show good performance for temperature and relative humidity whereas ACM2, MYNN show better performance for wind speed though these may vary for different climatic zones. Geopotential height and wind over 850 hPa is well simulated by ACM2 and MYNN over India. For PBL height ACM2, MYNN and MYJ works best for Chennai, New Delhi and Kolkata respectively during summer period. However, for winter period MYJ works best for Chennai while, QNSE works best for New Delhi and Kolkata. Considering all meteorological parameters together, it is seen that for arid zone ACM2, QNSE and MYJ schemes work reasonably well. For temperate zone, ACM2, QNSE and MYNN schemes show better results. For tropical zone all PBL schemes work closely. Hence, depending on the application, parameter and climate zone, this study provides suitable recommendations for choosing PBL schemes appropriately for each zone and parameter separately for the Indian region.

  10. Validation of chronic kidney disease risk categorization system in Chinese patients with kidney disease: A cohort study.

    PubMed

    Liu, Qingyan; Lv, Jicheng; Li, Haixia; Jiao, Lili; Yang, Hongyun; Song, Yinan; Xu, Guobin

    2015-12-01

    To validate the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines risk stratification system based on the combination of estimated glomerular filtration rate (eGFR) and proteinuria. This was a cohort study. A total of 1219 study population were recruited. Estimated GFR and proteinuria measured by using 24 h urine protein excretion rate (PER) were predictors. Adverse outcomes included all-cause mortality (ACM) and end-stage renal disease (ESRD). Follow-up was done by regular visit, telephone interview and electronic medical records. Over a median follow-up of 4.6 years, 153 (12.6%) and 43 (3.5%) patients experienced ESRD and ACM, respectively. On multivariable analysis, the adjusted hazard ratio for ESRD and ACM (compared with patients with eGFR > 60 mL/min per 1.7  m²) was of 29.8 and 3.6 for those with eGFR of 15-29 mL/min per 1.73 m², respectively. The adjusted hazard ratio for ESRD and ACM (compared with patients with PER < 150 mg/24h) was of 15.9 and 3.9 for those with PER > 500 mg/24h. Higher KDIGO guidelines risk categories (indicating lower eGFR or higher proteinuria) were associated with a graded increase in the risk for the ESRD (P < 0.001) and ACM (P < 0.001). Reclassification of KDIGO guidelines risk categories yielded net reclassification improvements for those with ESRD or ACM event (NRIevents ) of 33.3% or 30.2%. Lower eGFR and higher proteinuria are risk factors for ESRD and ACM in Chinese patients. The KDIGO guidelines risk categorization system assigned patients who went on to have the event to more appropriate CKD risk categories. © 2015 Asian Pacific Society of Nephrology.

  11. Acute confusional migraine: is it a distinct form of migraine?

    PubMed

    Pacheva, I; Ivanov, I

    2013-03-01

    The International Classification of Headache Disorders (ICHD-II) - 2004 recognises many migraine variants (different from migraine without aura and migraine with typical aura), but acute confusional migraine (ACM) remains unclassified and most clinicians are not well acquainted with it. The aim of this study was to illustrate ACM in the neuropaediatric practice, to discuss its place in the ICHD-II and to propose diagnostic criteria. A total of 2509 files of newly diagnosed patients, aged 0-18 years, treated as in- and outpatients in the Neuropaediatric Ward at the Plovdiv Medical University Hospital between 2002 and 2006 were screened retrospectively. Their diagnosis was based on detailed medical history, physical and neurological examination, additional functional, imaging and laboratory investigations. Migraine and migraine variants were diagnosed according to ICHD-II, but specific forms (e.g. ACM and Alice in wonderland syndrome) were also included. One hundred and eleven patients met the diagnostic criteria for migraine. Migraine variants comprised 24.3% of all migraine cases. In particular, ACM represented 11.1% of migraine variants or 2.7% of migraine and 0.12% of all paediatric neurological diseases. Here, we report three cases of ACM with analysis of the typical clinical and EEG features, review the literature and propose diagnostic criteria. ACM may present as either the only manifestation of a migraine attack or in the context of other migraine forms. ACM should have its own distinct place in the ICHD-II, may be as a subtype of migraine with complex aura. © 2013 Blackwell Publishing Ltd.

  12. Mapping tissue inhomogeneity in acute myocarditis: a novel analytical approach to quantitative myocardial edema imaging by T2-mapping.

    PubMed

    Baeßler, Bettina; Schaarschmidt, Frank; Dick, Anastasia; Stehning, Christian; Schnackenburg, Bernhard; Michels, Guido; Maintz, David; Bunck, Alexander C

    2015-12-23

    The purpose of the present study was to investigate the diagnostic value of T2-mapping in acute myocarditis (ACM) and to define cut-off values for edema detection. Cardiovascular magnetic resonance (CMR) data of 31 patients with ACM were retrospectively analyzed. 30 healthy volunteers (HV) served as a control. Additionally to the routine CMR protocol, T2-mapping data were acquired at 1.5 T using a breathhold Gradient-Spin-Echo T2-mapping sequence in six short axis slices. T2-maps were segmented according to the 16-segments AHA-model and segmental T2 values as well as the segmental pixel-standard deviation (SD) were analyzed. Mean differences of global myocardial T2 or pixel-SD between HV and ACM patients were only small, lying in the normal range of HV. In contrast, variation of segmental T2 values and pixel-SD was much larger in ACM patients compared to HV. In random forests and multiple logistic regression analyses, the combination of the highest segmental T2 value within each patient (maxT2) and the mean absolute deviation (MAD) of log-transformed pixel-SD (madSD) over all 16 segments within each patient proved to be the best discriminators between HV and ACM patients with an AUC of 0.85 in ROC-analysis. In classification trees, a combined cut-off of 0.22 for madSD and of 68 ms for maxT2 resulted in 83% specificity and 81% sensitivity for detection of ACM. The proposed cut-off values for maxT2 and madSD in the setting of ACM allow edema detection with high sensitivity and specificity and therefore have the potential to overcome the hurdles of T2-mapping for its integration into clinical routine.

  13. Eddies as trigger for diatom productivity in the open-ocean Northeast Atlantic

    NASA Astrophysics Data System (ADS)

    Romero, Oscar E.; Fischer, Gerhard; Karstensen, Johannes; Cermeño, Pedro

    2016-09-01

    Anticyclonic mesoscale eddies (ACME) have been proposed as a mechanism by which new nutrients are episodically delivered into the euphotic zone, thereby enhancing new production as well as shifting phytoplankton community structure. In this paper, we report on a 34-month sediment trap experiment at the Cape Verde Ocean Observatory (CVOO; ca. 18°N, 24°E; December 2009-October 2012), occasionally influenced by ACME passages. The typically oligotrophic, weakly seasonal particle flux pattern at the CVOO is strongly modified by the appearance of a highly productive and low oxygen ACME. Out of four recorded diatom flux maxima at CVOO, three were associated with the passage of ACMEs. The recorded diatom maxima events support the view that local ACME dynamics promotes upward nutrient supply into the euphotic zone leading to a rapid response of diatoms. This response is clearly reflected by the flux seasonality: between 40% and 60% of the total annual diatom flux at the CVOO site was intercepted in a relatively short time interval (<60 days). A highly diverse diatom community characterized the diatom fluxes throughout. Along with the ACME passages, small species of the genus Nitzschia, and Thalassionema nitzschioides var. parva dominated and delivered a major portion of the opal and organic carbon into deeper waters at site CVOO. Several pelagic, warm-water background species became dominant during intervals with low nutrient availability in the euphotic zone. Results of our interannual time-series suggest that ACMEs impact on total diatom production and the species-specific composition of the assemblage north of the Cave Verde Islands, and can strengthen the biological pump in open-ocean, oligotrophic subtropical regions of the world ocean. Our observations are useful for testing biogeochemical ocean models and will also help in improving the knowledge of processes and mechanisms behind interannual time-series of bulk components and microorganisms in pelagic and

  14. Six Sigma pricing.

    PubMed

    Sodhi, ManMohan S; Sodhi, Navdeep S

    2005-05-01

    Many companies are now good at managing costs and wringing out manufacturing efficiencies. The TQM movement and the disciplines of Six Sigma have seen to that. But the discipline so often brought to the cost side of the business equation is found far less commonly on the revenue side. The authors describe how a global manufacturer of industrial equipment, which they call Acme Incorporated, recently applied Six Sigma to one major revenue related activity--the price-setting process. It seemed to Acme's executives that pricing closely resembled many manufacturing processes. So, with the help of a Six Sigma black belt from manufacturing, a manager from Acme's pricing division recruited a team to carry out the five Six Sigma steps: Define what constitutes a defect. At Acme, a defect was an item sold at an unauthorized price. Gather data and prepare it for analysis. That involved mapping out the existing pricing-agreement process. Analyze the data. The team identified the ways in which people failed to carry out or assert effective control at each stage. Recommend modifications to the existing process. The team sought to decrease the number of unapproved prices without creating an onerous approval apparatus. Create controls. This step enabled Acme to sustain and extend the improvements in its pricing procedures. As a result of the changes, Acme earned dollar 6 million in additional revenue on one product line alone in the six months following implementation--money that went straight to the bottom line. At the same time, the company removed much of the organizational friction that had long bedeviled its pricing process. Other companies can benefit from Acme's experience as they look for ways to exercise price control without alienating customers.

  15. Validation of an Ambulatory Capacity Measure in Parkinson Disease: A Construct Derived from the Unified Parkinson’s Disease Rating Scale

    PubMed Central

    Parashos, Sotirios A.; Elm, Jordan; Boyd, James T.; Chou, Kelvin L.; Dai, Lin; Mari, Zoltan; Morgan, John C.; Sudarsky, Lewis; Wielinski, Catherine L.

    2015-01-01

    Background A construct calculated as the sum of items 13, 14, 15, 29, 30 of the Unified Parkinson’s Disease Rating Scale (UPDRS) has been used as an “Ambulatory Capacity Measure” (ACM in Parkinson disease (PD). Its construct validity has never been examined. A similar construct, consisting of the mean value of the same UPDRS items has been used under the acronym PIGD as a measure of postural instability and gait disorder in PD. Objective To examine the construct validity of the ACM and PIGD in PD. Methods We analyzed data in an existing database of 340 PD patients, Hoehn and Yahr stages (HYS) 1–5 who participated in a study of falls. Number of falls (NOF) was recorded over 4 weeks, and UPDRS (mental, ADL, and motor subscales), HYS, Activities Based Confidence Scale (ABC), Freezing of Gait Questionnaire (FOG), Five Times Sit-to-Stand (FTSS), Timed Up-and Go (TUG), Gait Velocity (GV), and Berg Balance Scale (BBS) evaluations were performed. Internal consistency was assessed by Cronbach’s alpha. Construct validity was assessed through correlations of the ACM and PIGD to these measures and to their summed-ranks. A coefficient of determination was calculated through linear regression. Results Mean age was 71.4, mean age at diagnosis 61.4 years; 46% were women; mean UPDRS subscale scores were: mental 3.7; ADL 15.7; motor: 27.1; mean ACM was 6.51, and mean PIGD 1.30. Cronbach’s alpha was 0.78 for both ACM and PIGD. Spearman correlation coefficients between the ACM/PIGD and ABC, FOG, TUG, GV and BBS were 0.69, 0.72, 0.67, 0.58, and 0.70 respectively. Correlation between the ACM/PIGD and summed-ranks of HYS, NOF, ABC, FOG, FTSS, TUG, GV and BBS was high (Spearman r=0.823, p <0.0001); 68% of the variability in the summed-ranks was explained by ACM/PIGD. Conclusion The ACM and the PIGD are valid global measures and accurately reflect the combined effects of the various components of ambulatory capacity in PD patients with HY stages 1–4. PMID:25311202

  16. Validation of an ambulatory capacity measure in Parkinson disease: a construct derived from the Unified Parkinson's Disease Rating Scale.

    PubMed

    Parashos, Sotirios A; Elm, Jordan; Boyd, James T; Chou, Kelvin L; Dai, Lin; Mari, Zoltan; Morgan, John C; Sudarsky, Lewis; Wielinski, Catherine L

    2015-01-01

    A construct calculated as the sum of items 13-15, 29, 30 of the Unified Parkinson's Disease Rating Scale (UPDRS) has been used as an "Ambulatory Capacity Measure" (ACM) in Parkinson disease (PD). Its construct validity has never been examined. A similar construct, consisting of the mean value of the same UPDRS items has been used under the acronym PIGD as a measure of postural instability and gait disorder in PD. To examine the construct validity of the ACM and PIGD in PD. We analyzed data in an existing database of 340 PD patients, Hoehn and Yahr stages (HYS) 1-5 who participated in a study of falls. Number of falls (NOF) was recorded over 4 weeks, and UPDRS (mental, ADL, and motor subscales), HYS, Activities Based Confidence Scale (ABC), Freezing of Gait Questionnaire (FOG), Five Times Sit-to-Stand (FTSS), Timed Up-and Go (TUG), Gait Velocity (GV), and Berg Balance Scale (BBS) evaluations were performed. Internal consistency was assessed by Cronbach's alpha. Construct validity was assessed through correlations of the ACM and PIGD to these measures and to their summed-ranks. A coefficient of determination was calculated through linear regression. Mean age was 71.4, mean age at diagnosis 61.4 years; 46% were women; mean UPDRS subscale scores were: Mental 3.7; ADL 15.7; motor: 27.1; mean ACM was 6.51, and mean PIGD 1.30. Cronbach's alpha was 0.78 for both ACM and PIGD. Spearman correlation coefficients between the ACM/PIGD and ABC, FOG, TUG, GV and BBS were 0.69, 0.72, 0.67, 0.58, and 0.70 respectively. Correlation between the ACM/PIGD and summed-ranks of HYS, NOF, ABC, FOG, FTSS, TUG, GV and BBS was high (Spearman r = 0.823, p < 0.0001); 68% of the variability in the summed-ranks was explained by ACM/PIGD. The ACM and the PIGD are valid global measures and accurately reflect the combined effects of the various components of ambulatory capacity in PD patients with HY stages 1-4.

  17. Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy.

    PubMed

    Turkowski, Kari L; Tester, David J; Bos, J Martijn; Haugaa, Kristina H; Ackerman, Michael J

    2017-03-01

    Arrhythmogenic cardiomyopathy (ACM) is a heritable disease characterized by fibrofatty replacement of cardiomyocytes, has a prevalence of approximately 1 in 5000 individuals, and accounts for approximately 20% of sudden cardiac death in the young (≤35 years). ACM is most often inherited as an autosomal dominant trait with incomplete penetrance and variable expression. While mutations in several genes that encode key desmosomal proteins underlie about half of all ACM, the remainder is elusive genetically. Here, whole exome sequencing (WES) was performed with genomic triangulation in an effort to identify a novel explanation for a phenotype-positive, genotype-negative multi-generational pedigree with a presumed autosomal dominant, maternal inheritance of ACM. WES and genomic triangulation was performed on a symptomatic 14-year-old female proband, her affected mother and affected sister, and her unaffected father to elucidate a novel ACM-susceptibility gene for this pedigree. Following variant filtering using Ingenuity® Variant Analysis, gene priority ranking was performed on the candidate genes using ToppGene and Endeavour. The phylogenetic and physiochemical properties of candidate mutations were assessed further by 6 in silico prediction tools. Species alignment and amino acid conservation analysis was performed using the Uniprot Consortium. Tissue expression data was abstracted from Expression Atlas. Following WES and genomic triangulation, CDH2 emerged as a novel, autosomal dominant, ACM-susceptibility gene. The CDH2-encoded N-cadherin is a cell-cell adhesion protein predominately expressed in the heart. Cardiac dysfunction has been demonstrated in prior CDH2 knockout and over-expression animal studies. Further in silico mutation prediction, species conservation, and protein expression analysis supported the ultra-rare (minor allele frequency <0.005%) p.Asp407Asn-CDH2 variant as a likely pathogenic variant. Herein, it is demonstrated that genetic mutations in

  18. Cell surface display system for Lactococcus lactis: a novel development for oral vaccine.

    PubMed

    Raha, A R; Varma, N R S; Yusoff, K; Ross, E; Foo, H L

    2005-07-01

    The food-grade Lactococcus lactis is a potential vector to be used as a live vehicle for the delivery of heterologous proteins for vaccine and pharmaceutical purposes. We constructed a plasmid vector pSVac that harbors a 255-bp single-repeat sequence of the cell wall-binding protein region of the AcmA protein. The recombinant plasmid was transformed into Escherichia coli and expression of the gene fragment was driven by the T7 promoter of the plasmid. SDS-PAGE showed the presence of the putative AcmA' fragment and this was confirmed by Western blot analysis. The protein was isolated and purified using a His-tag affinity column. When mixed with a culture of L. lactis MG1363, ELISA and immunofluorescence assays showed that the cell wall-binding fragment was anchored onto the outer surface of the bacteria. This indicated that the AcmA' repeat unit retained the active site for binding onto the cell wall surface of the L. lactis cells. Stability assays showed that the fusion proteins (AcmA/A1, AcmA/A3) were stably docked onto the surface for at least 5 days. The AcmA' fragment was also shown to be able to strongly bind onto the cell surface of naturally occurring lactococcal strains and Lactobacillus and, with less strength, the cell surface of Bacillus sphericus. The new system designed for cell surface display of recombinant proteins on L. lactis was evaluated for the expression and display of A1 and A3 regions of the VP1 protein of enterovirus 71 (EV71). The A1 and A3 regions of the VP1 protein of EV71 were cloned upstream to the cell wall-binding domains of AcmA protein and successfully expressed as AcmA/A1 and AcmA/A3. Whole-cell ELISA showed the successful display of VP1 protein epitopes of EV71 on the surface of L. lactis. The success of the anchoring system developed in this study for docking the A1 and A3 epitopes of VP1 onto the surface of L. lactis cells opens up the possibilities of peptide and protein display for not only Lactococcus but also for other gram

  19. Self-Organized Amorphous TiO2 Nanotube Arrays on Porous Ti Foam for Rechargeable Lithium and Sodium Ion Batteries

    SciTech Connect

    Bi, Zhonghe; Paranthaman, Mariappan Parans; Menchhofer, Paul A; Dehoff, Ryan R; Bridges, Craig A; Chi, Miaofang; Guo, Bingkun; Sun, Xiao-Guang; Dai, Sheng

    2013-01-01

    Self-organized amorphous TiO2 nanotube arrays (NTAs) were successfully fabricated on both Ti foil and porous Ti foam through electrochemical anodization techniques. The starting Ti foams were fabricated using ARCAM s Electron Beam Melting (EBM) technology. The TiO2 NTAs on Ti foam were used as anodes in lithium ion batteries; they exhibited high capacities of 103 Ahcm-2 at 10 Acm-2 and 83 Ahcm-2 at 500 Acm-2, which are two to three times higher than those achieved on the standard Ti foil, which is around 40 Ahcm-2 at 10 Acm-2 and 24 Ahcm-2 at 500 Acm-2, respectively. This improvement is mainly attributed to higher surface area of the Ti foam and higher porosity of the nanotube arrays layer grown on the Ti foam. In addition, a Na-ion half-cell composed of these NTAs anodes and Na metal showed a self-improving specific capacity upon cycling at 10 Acm-2. These results indicate that TiO2 NTAs grown on Ti porous foam are promising electrodes for Li-ion or Na-ion rechargeable batteries.

  20. Visceral fat adipocytes from obese and colorectal cancer subjects exhibit distinct secretory and ω6 polyunsaturated fatty acid profiles and deliver immunosuppressive signals to innate immunity cells

    PubMed Central

    Conti, Lucia; Scazzocchio, Beatrice; Varì, Rosaria; Donninelli, Gloria; Varano, Barbara; Giammarioli, Stefania; De Meo, Simone; Silecchia, Gianfranco; Pennestrì, Francesco; Persiani, Roberto; Masella, Roberta; Gessani, Sandra

    2016-01-01

    Obesity is a low-grade chronic inflammatory state representing an important risk factor for colorectal cancer (CRC). Adipocytes strongly contribute to inflammation by producing inflammatory mediators. In this study we investigated the role of human visceral fat adipocytes in regulating the functions of innate immunity cells. Adipocyte-conditioned media (ACM) from obese (n = 14) and CRC (lean, n = 14; obese, n = 13) subjects released higher levels of pro-inflammatory/immunoregulatory factors as compared to ACM from healthy lean subjects (n = 13). Dendritic cells (DC), differentiated in the presence of ACM from obese and CRC subjects, expressed elevated levels of the inhibitory molecules PD-L1 and PD-L2, and showed a reduced IL-12/IL-10 ratio in response to both TLR ligand- and γδ T lymphocyte-induced maturation. Furthermore, CRC patient-derived ACM inhibited DC-mediated γδ T cell activation. The immunosuppressive signals delivered by ACM from obese and CRC individuals were associated with a pro-inflammatory secretory and ω6 polyunsaturated fatty acid profile of adipocytes. Interestingly, STAT3 activation in adipocytes correlated with dihomo-γlinolenic acid content and was further induced by arachidonic acid, which conversely down-modulated PPARγ. These results provide novel evidence for a cross-talk between human adipocytes and innate immunity cells whose alteration in obesity and CRC may lead to immune dysfunctions, thus setting the basis for cancer development. PMID:27494857

  1. Activated carbon electrode from banana-peel waste for supercapacitor applications

    NASA Astrophysics Data System (ADS)

    Taer, E.; Taslim, R.; Aini, Z.; Hartati, S. D.; Mustika, W. S.

    2017-01-01

    Seven types of activated carbon electrode (ACM) have been produced from the banana peel waste for supercapacitor application. The difference type of the electrode was synthesized by the various conditions of carbonization and activation. The production of the ACM was begun by the milling process and molded by a solution casting technique. The next step was followed by drying, carbonization and activation process. Physical properties of the ACM were studied by the N2 gas absorption-desorption method to characterize the specific surface area of the sample. On the other side, the electrochemical properties such as specific capacitance (Csp), specific energy (E) and specific power (P) were resulted by calculating the current (I) and voltage (V) data from the cyclic voltammetry testing. Based on the data obtained the surface area of the ACM has a significant relationship with the electrochemical properties. The specific surface area (SBET), Csp, E and P were found the maximum value as high as 581m2 / g, 68 F/g, 0.75 Wh/kg and 31 W/kg, respectively. Further more, this paper were also analyzed the relationship between electrochemical properties of supercapacitor with the degree of crystallization of the ACM.

  2. Liver segmentation with new supervised method to create initial curve for active contour.

    PubMed

    Zareei, Abouzar; Karimi, Abbas

    2016-08-01

    The liver performs a critical task in the human body; therefore, detecting liver diseases and preparing a robust plan for treating them are both crucial. Liver diseases kill nearly 25,000 Americans every year. A variety of image segmentation methods are available to determine the liver's position and to detect possible liver tumors. Among these is the Active Contour Model (ACM), a framework which has proven very sensitive to initial contour delineation and control parameters. In the proposed method based on image energy, we attempted to obtain an initial segmentation close to the liver's boundary, and then implemented an ACM to improve the initial segmentation. The ACM used in this work incorporates gradient vector flow (GVF) and balloon energy in order to overcome ACM limitations, such as local minima entrapment and initial contour dependency. Additionally, in order to adjust active contour control parameters, we applied a genetic algorithm to produce a proper parameter set close to the optimal solution. The pre-processing method has a better ability to segment the liver tissue during a short time with respect to other mentioned methods in this paper. The proposed method was performed using Sliver CT image datasets. The results show high accuracy, precision, sensitivity, specificity and low overlap error, MSD and runtime with few ACM iterations.

  3. High-performance implementations and large-scale validation of the link-wise artificial compressibility method

    NASA Astrophysics Data System (ADS)

    Obrecht, Christian; Asinari, Pietro; Kuznik, Frédéric; Roux, Jean-Jacques

    2014-10-01

    The link-wise artificial compressibility method (LW-ACM) is a recent formulation of the artificial compressibility method for solving the incompressible Navier-Stokes equations. Two implementations of the LW-ACM in three dimensions on CUDA enabled GPUs are described. The first one is a modified version of a state-of-the-art CUDA implementation of the lattice Boltzmann method (LBM), showing that an existing GPU LBM solver might easily be adapted to LW-ACM. The second one follows a novel approach, which leads to a performance increase of up to 1.8× compared to the LBM implementation considered here, while reducing the memory requirements by a factor of 5.25. Large-scale simulations of the lid-driven cubic cavity at Reynolds number Re=2000 were performed for both LW-ACM and LBM. Comparison of the simulation results against spectral elements reference data shows that LW-ACM performs almost as well as multiple-relaxation-time LBM in terms of accuracy.

  4. Morphological changes during enhanced carbonation of asbestos containing material and its comparison to magnesium silicate minerals.

    PubMed

    Gadikota, Greeshma; Natali, Claudio; Boschi, Chiara; Park, Ah-Hyung Alissa

    2014-01-15

    The disintegration of asbestos containing materials (ACM) over time can result in the mobilization of toxic chrysotile ((Mg, Fe)3Si2O5(OH)4)) fibers. Therefore, carbonation of these materials can be used to alter the fibrous morphology of asbestos and help mitigate anthropogenic CO2 emissions, depending on the amount of available alkaline metal in the materials. A series of high pressure carbonation experiments were performed in a batch reactor at PCO2 of 139atm using solvents containing different ligands (i.e., oxalate and acetate). The results of ACM carbonation were compared to those of magnesium silicate minerals which have been proposed to permanently store CO2 via mineral carbonation. The study revealed that oxalate even at a low concentration of 0.1M was effective in enhancing the extent of ACM carbonation and higher reaction temperatures also resulted in increased ACM carbonation. Formation of phases such as dolomite ((Ca, Mg)(CO3)2), whewellite (CaC2O4·H2O) and glushinskite (MgC2O4·2H2O) and a reduction in the chrysotile content was noted. Significant changes in the particle size and surface morphologies of ACM and magnesium silicate minerals toward non-fibrous structures were observed after their carbonation.

  5. Link-wise artificial compressibility method

    NASA Astrophysics Data System (ADS)

    Asinari, Pietro; Ohwada, Taku; Chiavazzo, Eliodoro; Di Rienzo, Antonio F.

    2012-06-01

    The artificial compressibility method (ACM) for the incompressible Navier-Stokes equations is (link-wise) reformulated (referred to as LW-ACM) by a finite set of discrete directions (links) on a regular Cartesian mesh, in analogy with the lattice Boltzmann method (LBM). The main advantage is the possibility of exploiting well established technologies originally developed for LBM and classical computational fluid dynamics, with special emphasis on finite differences (at least in the present paper), at the cost of minor changes. For instance, wall boundaries not aligned with the background Cartesian mesh can be taken into account by tracing the intersections of each link with the wall (analogously to LBM technology). LW-ACM requires no high-order moments beyond hydrodynamics (often referred to as ghost moments) and no kinetic expansion. Like finite difference schemes, only standard Taylor expansion is needed for analyzing consistency. Preliminary efforts towards optimal implementations have shown that LW-ACM is capable of similar computational speed as optimized (BGK-) LBM. In addition, the memory demand is significantly smaller than (BGK-) LBM. Importantly, with an efficient implementation, this algorithm may be among the few which are compute-bound and not memory-bound. Two- and three-dimensional benchmarks are investigated, and an extensive comparative study between the present approach and state of the art methods from the literature is carried out. Numerical evidences suggest that LW-ACM represents an excellent alternative in terms of simplicity, stability and accuracy.

  6. Estimating the Additional Greenhouse Gas Emissions in Korea: Focused on Demolition of Asbestos Containing Materials in Building

    PubMed Central

    Kim, Young-Chan; Hong, Won-Hwa; Zhang, Yuan-Long; Son, Byeung-Hun; Seo, Youn-Kyu; Choi, Jun-Ho

    2016-01-01

    When asbestos containing materials (ACM) must be removed from the building before demolition, additional greenhouse gas (GHG) emissions are generated. However, precedent studies have not considered the removal of ACM from the building. The present study aimed to develop a model for estimating GHG emissions created by the ACM removal processes, specifically the removal of asbestos cement slates (ACS). The second objective was to use the new model to predict the total GHG emission produced by ACM removal in the entire country of Korea. First, an input-equipment inventory was established for each step of the ACS removal process. Second, an energy consumption database for each equipment type was established. Third, the total GHG emission contributed by each step of the process was calculated. The GHG emissions generated from the 1,142,688 ACS-containing buildings in Korea was estimated to total 23,778 tonCO2eq to 132,141 tonCO2eq. This study was meaningful in that the emissions generated by ACS removal have not been studied before. Furthermore, the study deals with additional problems that can be triggered by the presence of asbestos in building materials. The method provided in this study is expected to contribute greatly to the calculation of GHG emissions caused by ACM worldwide. PMID:27626433

  7. Chiropractic Care for Headaches and Dizziness of a 34-Year-Old Woman Previously Diagnosed With Arnold-Chiari Malformation Type 1

    PubMed Central

    Sergent, Adam W.; Cofano, Gregory P.

    2014-01-01

    Objective The purpose of this case study is to describe the chiropractic care of a patient with headaches and dizziness. Clinical Features A 34-year-old woman with a history of headaches, dizziness, photophobia, and temporary loss of vision aggravated by postural positions while bending forward sought conservative care for her symptoms. She reported a prior diagnosis of Arnold-Chiari malformation (ACM) type 1 by magnetic resonance imaging in 2005 that revealed descending cerebellar tonsils measured at 5 mm with an impression of ACM type 1. A new magnetic resonance image taken in 2013 indicated the cerebellar tonsils measured at 3 mm and did not project through the plane of the foramen magnum. The diagnosis of ACM type 1 was no longer applicable; however, the signs and symptoms of ACM type 1 persisted. Intervention and Outcome She was treated using cervical chiropractic manipulation using diversified technique. The dizziness and headache were resolved after 3 visits. At her 3-month follow-up, she continued to be symptom-free. Conclusion A patient with headaches and dizziness and a previous diagnosis of ACM type 1 responded positively to chiropractic care. PMID:25225468

  8. Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture.

    PubMed

    Rasgele, Pinar Göç

    2014-03-01

    Pesticides are one of the most potent environmental contaminants, which accumulate in biotic and abiotic components of ecosystems. Acetamiprid (Acm), a neonicotinoid insecticide, and Propineb (Pro), a dithiocarbamate fungicide, are widely used to control sucking insects and fungal infections on crops, respectively. The present study was undertaken to investigate the genotoxic effects of these compounds, individually and in mixtures, in mouse germ cells by using the sperm morphology assay. Mice were injected intraperitoneally with 0.625, 1.25, and 2.50 μg mL⁻¹ of Acm, 12.5, 25, and 50 μg mL⁻¹ of Pro, and their mixture at the same concentrations over 24 and 48 h. Acm did not significantly increase the percentage of abnormal sperm at any concentration. The frequency of abnormal sperm significantly increased after 24 and 48 h of exposure to 50 μg mL⁻¹ of Pro. The mixtures of 2.50 μg mL⁻¹ of Acm and 50 μg mL⁻¹ of Pro induced sperm abnormalities antagonistically both after 24 and 48 h of exposure. Results suggest that Acm was non-genotoxic for mouse germ cells, while Pro may have been a germ cell mutagen due to the observed increase in the frequency of sperm abnormalities. However, to gain better insight into the mutagenicity and DNA damaging potential of both of these pesticides, further studies at molecular level should be done.

  9. Posterior fossa decompression combined with resection of the cerebellomedullary fissure membrane and expansile duraplasty: a radical and rational surgical treatment for Arnold-Chiari type I malformation.

    PubMed

    Liang, Chen Jian; Dong, Qiu Jian; Xing, You Heng; Shan, Ma; Wen, Lian Xiao; Qiang, Zhong Yuan; Ping, Zhang Qing; Tao, Peng Zhi; Ping, Huang Xiao

    2014-12-01

    This study aims to introduce a new surgical procedure for the treatment of Arnold-Chiari type I malformation (ACM-1) and to compare its effectiveness with the techniques described in previous studies. We performed the following procedures: foramen magnum decompression combined with the removal of both the atlanto-occipital membrane, extended resection of the cerebellomedullary fissure arachnoid membrane, and artificial duraplasty to enlarge the membranic posterior fossa without resecting the cerebellar tonsils and syringosubarachnoid shunting. There were 21 ACM-1 patients: 12 cases had osteo-compression on the cerebellar hemisphere, 18 cases had thickened adhered fabric ring that stretched from arachnoid membrane to cerebellar hemisphere, and 15 cases with syringomyelia. The patients were followed up for 6 months to 3 years after the surgery. All patients showed a remarkable recovery of syringomyelia. There were no morbidity or death related to the surgery. Most of ACM-1 patients, the osteo- and membrane compression on cerebellar hemisphere and tonsil were observed during the operation. Therefore, decompression of foramen magnum and posterior craniocervical combined with the removal of cerebellomedullary fissure arachnoid membrane and placement of an artificial dural graft should be considered as a comprehensive option of minimally invasive surgery and rational and radical treatment of ACM-1. Our experience showed that, by using our procedure, shunting becomes no longer necessary in the treatment of ACM-1-associated syringomyelia.

  10. Periodontal Responses to Augmented Corticotomy with Collagen Membrane Application during Orthodontic Buccal Tipping in Dogs

    PubMed Central

    Herr, Yeek; Kwon, Young-Hyuk; Kim, Seong-Hun; Kim, Eun-Cheol

    2014-01-01

    This prospective randomized split-mouth study was performed to examine the effects of absorbable collagen membrane (ACM) application in augmented corticotomy using deproteinized bovine bone mineral (DBBM), during orthodontic buccal tipping movement in the dog. After buccal circumscribing corticotomy and DBBM grafting into the decorticated area, flaps were repositioned and sutured on control sides. ACM was overlaid and secured with membrane tacks, on test sides only, and the flaps were repositioned and sutured. Closed coil springs were used to apply 200 g orthodontic force in the buccolingual direction on the second and third premolars, immediately after primary flap closure. The buccal tipping angles were 31.19 ± 14.60° and 28.12 ± 11.48° on the control and test sides, respectively. A mean of 79.5 ± 16.0% of the buccal bone wall was replaced by new bone on the control side, and on the test side 78.9 ± 19.5% was replaced. ACM application promoted an even bone surface. In conclusion, ACM application in augmented corticotomy using DBBM might stimulate periodontal tissue reestablishment, which is useful for rapid orthodontic treatment or guided bone regeneration. In particular, ACM could control the formation of mesenchymal matrix, facilitating an even bone surface. PMID:25276824

  11. Effect of electrolyte concentration on performance of supercapacitor carbon electrode from fibers of oil palm empty fruit bunches

    SciTech Connect

    Farma, R.; Awitdrus,; Taer, E.; Deraman, M. Talib, I. A.; Omar, R.; Ishak, M. M.; Basri, N. H.; Dolah, B. N. M.

    2015-04-16

    Fibers of oil palm empty fruit bunches were used to produce self-adhesive carbon grains (SACG). The SACG green monoliths were carbonized in N{sub 2} environment at 800°C to produce carbon monoliths (CM) and the CM was CO{sub 2} activated at 800°C for 4 hour to produce activated carbon monolith electrodes (ACM). The physical properties of the CMs and ACMs were investigated using X-ray diffraction, field emission scanning electron microscopy and nitrogen adsorption-desorption. ACMs were used as electrode to fabricate symmetry supercapacitor cells and the cells which used H{sub 2}SO{sub 4} electrolyte at 0.5, 1.0 and 1.5 M were investigated using electrochemical impedance spectroscopy, cyclic voltammetry and galvanostatic charge-discharge standard techniques. In this paper we report the physical properties of the ACM electrodes and the effect of electrolyte concentration on the electrochemical properties the ACM electrodes.

  12. Joule-Heating-Induced Damage in Cu-Al Wedge Bonds Under Current Stressing

    NASA Astrophysics Data System (ADS)

    Yang, Tsung-Han; Lin, Yu-Min; Ouyang, Fan-Yi

    2014-01-01

    Copper wires are increasingly used to replace gold wires in wire-bonding technology owing to their better electrical properties and lower cost. However, not many studies have been conducted on electromigration-induced failure of Cu wedge bonds on Al metallization. In this study, we investigated the failure mechanism of Cu-Al wedge bonds under high current stressing from 4 × 104 A/cm2 to 1 × 105 A/cm2 at ambient temperature of 175°C. The resistance evolution of samples during current stressing and the microstructure of the joint interface between the Cu wire and Al-Si bond pad were examined. The results showed that abnormal crack formation accompanying significant intermetallic compound growth was observed at the second joint of the samples, regardless of the direction of electric current for both current densities of 4 × 104 A/cm2 and 8 × 104 A/cm2. We propose that this abnormal crack formation at the second joint is mainly due to the higher temperature induced by the greater Joule heating at the second joint for the same current stressing, because of its smaller bonded area compared with the first joint. The corresponding fluxes induced by the electric current and chemical potential difference between Cu and Al were calculated and compared to explain the failure mechanism. For current density of 1 × 105 A/cm2, the Cu wire melted within 0.5 h owing to serious Joule heating.

  13. Plasma synthesized doped B powders for MgB 2 superconductors

    NASA Astrophysics Data System (ADS)

    Marzik, J. V.; Suplinskas, R. J.; Wilke, R. H. T.; Canfield, P. C.; Finnemore, D. K.; Rindfleisch, M.; Margolies, J.; Hannahs, S. T.

    2005-07-01

    Gas phase plasma synthesis methods have been used to prepare nano-scale particles of C doped boron powder that are well suited for powder-in-tube (PIT) fabrication of superconducting wire. Mixtures of H2, BCl3, and CH4 gas are injected into an induction plasma where doped boron powder is formed and collected on a stainless steel screen. The particles typically are ∼20 nm in size and collect into lacy agglomerates in the 1-50 μm size range. Pressed pellets of these powders heated in a Mg atmosphere are transformed to the MgB2 phase at temperatures ranging from 600 °C to 1200 °C. Critical current densities, Jc, at 5 K run from about 106 A/cm2 at self-field to 4 × 104 A/cm2 at 7 T. At 20 K, Jc ranges from 5 × 105 A/cm2 at self-field to about 104 A/cm2 at 3 T. Samples of pure B powder and B with 7.4%C powder were prepared as PIT wires having a combination Fe inner jacket and a cupro-nickel outer jacket. These PIT Jc values are lower than, but comparable to the pressed pellet values. The PIT samples can be reacted in times on the order of 10 min and still exhibit greater than 105 A/cm2 at 5 K and 2 T.

  14. Estimation of the economic and health impact of complications of type 2 diabetes mellitus in the autonomous community of Madrid (Spain).

    PubMed

    Arrieta, Francisco; Rubio-Terrés, Carlos; Rubio-Rodríguez, Darío; Magaña, Ana; Piñera, Marbella; Iglesias, Pedro; Nogales, Pedro; Calañas, Alfonso; Novella, Blanca; Botella-Carretero, José Ignacio; Debán, Carlos; Zamarrón, Isabel; Mora, Gustavo; Balsa, José Antonio; Vázquez, Clotilde

    2014-04-01

    To estimate the economic and health impact of chronic complications (macrovascular and microvascular) of type 2 diabetes mellitus (T2DM) in the autonomous community of Madrid (Spain) (ACM). The number of expected complications was obtained from a descriptive, cross-sectional study on a cohort of 3,268 patients with T2DM from the ACM. Cost of complications (€, 2012) was assessed both at hospitals and in primary care. The number of medical visits in primary care and drug treatment for complications were collected by a panel of 21 physicians experienced in treatment of T2DM. Population and epidemiological data and healthcare costs were obtained from Spanish sources. Univariate sensitivity analyses were performed. It is estimated that there are 390,944 patients with T2DM in the ACM, and that they experience 172,406 and 212,283 macrovascular and microvascular complications respectively during their lifetimes. Mean cost of T2DM complications per patient is estimated at € 4,121.54 (66% due to macrovascular complications). The economic impact of T2DM complications in the ACM would be € 1,611 million (1,065 and 545 millions from macrovascular and microvascular complications respectively). The economic impact would range from € 1,249 and 2.509 million euro depending on T2DM prevalence. Complications of T2DM have a great health and economic impact in ACM. Copyright © 2013 SEEN. Published by Elsevier Espana. All rights reserved.

  15. Estimating the Additional Greenhouse Gas Emissions in Korea: Focused on Demolition of Asbestos Containing Materials in Building.

    PubMed

    Kim, Young-Chan; Hong, Won-Hwa; Zhang, Yuan-Long; Son, Byeung-Hun; Seo, Youn-Kyu; Choi, Jun-Ho

    2016-09-12

    When asbestos containing materials (ACM) must be removed from the building before demolition, additional greenhouse gas (GHG) emissions are generated. However, precedent studies have not considered the removal of ACM from the building. The present study aimed to develop a model for estimating GHG emissions created by the ACM removal processes, specifically the removal of asbestos cement slates (ACS). The second objective was to use the new model to predict the total GHG emission produced by ACM removal in the entire country of Korea. First, an input-equipment inventory was established for each step of the ACS removal process. Second, an energy consumption database for each equipment type was established. Third, the total GHG emission contributed by each step of the process was calculated. The GHG emissions generated from the 1,142,688 ACS-containing buildings in Korea was estimated to total 23,778 tonCO₂eq to 132,141 tonCO₂eq. This study was meaningful in that the emissions generated by ACS removal have not been studied before. Furthermore, the study deals with additional problems that can be triggered by the presence of asbestos in building materials. The method provided in this study is expected to contribute greatly to the calculation of GHG emissions caused by ACM worldwide.

  16. On the Relationship between Variational Level Set-Based and SOM-Based Active Contours

    PubMed Central

    Abdelsamea, Mohammed M.; Gnecco, Giorgio; Gaber, Mohamed Medhat; Elyan, Eyad

    2015-01-01

    Most Active Contour Models (ACMs) deal with the image segmentation problem as a functional optimization problem, as they work on dividing an image into several regions by optimizing a suitable functional. Among ACMs, variational level set methods have been used to build an active contour with the aim of modeling arbitrarily complex shapes. Moreover, they can handle also topological changes of the contours. Self-Organizing Maps (SOMs) have attracted the attention of many computer vision scientists, particularly in modeling an active contour based on the idea of utilizing the prototypes (weights) of a SOM to control the evolution of the contour. SOM-based models have been proposed in general with the aim of exploiting the specific ability of SOMs to learn the edge-map information via their topology preservation property and overcoming some drawbacks of other ACMs, such as trapping into local minima of the image energy functional to be minimized in such models. In this survey, we illustrate the main concepts of variational level set-based ACMs, SOM-based ACMs, and their relationship and review in a comprehensive fashion the development of their state-of-the-art models from a machine learning perspective, with a focus on their strengths and weaknesses. PMID:25960736

  17. Anisotropy of complex magnetic susceptibility as an indicator of strain and petrofabric in rocks bearing sulphides

    NASA Astrophysics Data System (ADS)

    Borradaile, G. J.; Puumala, M.; Stupavsky, M.

    1992-02-01

    A new method, anisotropy of complex magnetic susceptibility (ACMS), for determining the petrofabric of specimens with conductive minerals is developed. The method uses the same induction coil equipment and techniques that can be used for the measurement of the anisotropy of magnetic susceptibility (AMS). However, a higher (100 kHz) operating frequency emphasizes the electrical conductivity response and thus yields a measure of the anisotropy of electrical conductivity of the specimen. The method was tested on variably deformed plasticine samples containing aluminium fabric markers and on synthetic aggregates of pyrrhotite and talc-pyrrhotite mixtures deformed triaxially at a confining pressure of 200 MPa (2 kbar) by up to 35% homogeneous shortening. ACMS successfully defines the petrofabric and permits prediction of the principal directions of finite strain. The intensity of AMS and, to a lesser extent, of ACMS correlate with the strain ratio in these simple, coaxial, flattening plane strain experimental deformations on selected materials.

  18. Climate Modeling: Ocean Cavities below Ice Shelves

    SciTech Connect

    Petersen, Mark Roger

    2016-09-12

    The Accelerated Climate Model for Energy (ACME), a new initiative by the U.S. Department of Energy, includes unstructured-mesh ocean, land-ice, and sea-ice components using the Model for Prediction Across Scales (MPAS) framework. The ability to run coupled high-resolution global simulations efficiently on large, high-performance computers is a priority for ACME. Sub-ice shelf ocean cavities are a significant new capability in ACME, and will be used to better understand how changing ocean temperature and currents influence glacial melting and retreat. These simulations take advantage of the horizontal variable-resolution mesh and adaptive vertical coordinate in MPAS-Ocean, in order to place high resolution below ice shelves and near grounding lines.

  19. Modeling aerosol emissions from the combustion of composite materials

    NASA Technical Reports Server (NTRS)

    Roop, J. A.; Caldwell, D. J.; Kuhlmann, K. J.

    1994-01-01

    The use of advanced composite materials (ACM) in the B-2 bomber, composite armored vehicle, and F-22 advanced tactical fighter has rekindled interest concerning the health risk of burned or burning ACM. The objective of this work was to determine smoke production from burning ACM and its toxicity. A commercial version of the UPITT II combustion toxicity method developed at the University of Pittsburgh, and subsequently refined through a US Army-funded basic research project, was used to established controlled combustion conditions which were selected to evaluate real-world exposure scenarios. Production and yield of toxic species varied with the combustion conditions. Previous work with this method showed that the combustion conditions directly influenced the toxicity of the decomposition products from a variety of materials.

  20. Hybrid thermal link-wise artificial compressibility method

    NASA Astrophysics Data System (ADS)

    Obrecht, Christian; Kuznik, Frédéric

    2015-10-01

    Thermal flow prediction is a subject of interest from a scientific and engineering points of view. Our motivation is to develop an accurate, easy to implement and highly scalable method for convective flows simulation. To this end, we present an extension to the link-wise artificial compressibility method (LW-ACM) for thermal simulation of weakly compressible flows. The novel hybrid formulation uses second-order finite difference operators of the energy equation based on the same stencils as the LW-ACM. For validation purposes, the differentially heated cubic cavity was simulated. The simulations remained stable for Rayleigh numbers up to Ra =108. The Nusselt numbers at isothermal walls and dynamics quantities are in good agreement with reference values from the literature. Our results show that the hybrid thermal LW-ACM is an effective and easy-to-use solution to solve convective flows.

  1. Time Accurate CFD Simulations of the Orion Launch Abort Vehicle in the Transonic Regime

    NASA Technical Reports Server (NTRS)

    Ruf, Joseph; Rojahn, Josh

    2011-01-01

    Significant asymmetries in the fluid dynamics were calculated for some cases in the CFD simulations of the Orion Launch Abort Vehicle through its abort trajectories. The CFD simulations were performed steady state with symmetric boundary conditions and geometries. The trajectory points at issue were in the transonic regime, at 0 and 5 angles of attack with the Abort Motors with and without the Attitude Control Motors (ACM) firing. In some of the cases the asymmetric fluid dynamics resulted in aerodynamic side forces that were large enough that would overcome the control authority of the ACMs. MSFC s Fluid Dynamics Group supported the investigation into the cause of the flow asymmetries with time accurate CFD simulations, utilizing a hybrid RANS-LES turbulence model. The results show that the flow over the vehicle and the subsequent interaction with the AB and ACM motor plumes were unsteady. The resulting instantaneous aerodynamic forces were oscillatory with fairly large magnitudes. Time averaged aerodynamic forces were essentially symmetric.

  2. Toward domain-specific design environments: Some representation ideas from the telecommunications domain

    NASA Technical Reports Server (NTRS)

    Greenspan, Sol; Feblowitz, Mark

    1992-01-01

    ACME is an experimental environment for investigating new approaches to modeling and analysis of system requirements and designs. ACME is built on and extends object-oriented conceptual modeling techniques and knowledge representation and reasoning (KRR) tools. The most immediate intended use for ACME is to help represent, understand, and communicate system designs during the early stages of system planning and requirements engineering. While our research is ostensibly aimed at software systems in general, we are particularly motivated to make an impact in the telecommunications domain, especially in the area referred to as Intelligent Networks (IN's). IN systems contain the software to provide services to users of a telecommunications network (e.g., call processing services, information services, etc.) as well as the software that provides the internal infrastructure for providing the services (e.g., resource management, billing, etc.). The software includes not only systems developed by the network proprietors but also by a growing group of independent service software providers.

  3. 444 nm InGaN light emitting diodes on low-defect-density (11\\bar{2}2) GaN templates on patterned sapphire

    NASA Astrophysics Data System (ADS)

    Khoury, Michel; Li, Hongjian; Kuritzky, Leah Y.; Mughal, Asad J.; DeMierry, Philippe; Nakamura, Shuji; Speck, James S.; DenBaars, Steven P.

    2017-10-01

    Efficient InGaN-based 444 nm blue light-emitting diodes (LEDs) were fabricated on low-defect-density (11\\bar{2}2) semipolar GaN templates grown on patterned r-sapphire. At 20 A/cm2, the packaged (11\\bar{2}2) LEDs exhibited a light output power of 2.9 mW (17.8 mW at 100 A/cm2) and a record peak external quantum efficiency of 6.4% showing a negligible efficiency droop and blue shift with drive currents up to 100 A/cm2. In addition, we demonstrated light extraction simulations for the (11\\bar{2}2) template, which showed that the structured pattern is not only beneficial for limiting the defect propagation but also increases the light extraction by 29% compared with GaN layers grown on planar substrates.

  4. Antenna Calibration and Measurement Equipment

    NASA Technical Reports Server (NTRS)

    Rochblatt, David J.; Cortes, Manuel Vazquez

    2012-01-01

    A document describes the Antenna Calibration & Measurement Equipment (ACME) system that will provide the Deep Space Network (DSN) with instrumentation enabling a trained RF engineer at each complex to perform antenna calibration measurements and to generate antenna calibration data. This data includes continuous-scan auto-bore-based data acquisition with all-sky data gathering in support of 4th order pointing model generation requirements. Other data includes antenna subreflector focus, system noise temperature and tipping curves, antenna efficiency, reports system linearity, and instrument calibration. The ACME system design is based on the on-the-fly (OTF) mapping technique and architecture. ACME has contributed to the improved RF performance of the DSN by approximately a factor of two. It improved the pointing performances of the DSN antennas and productivity of its personnel and calibration engineers.

  5. Evaluation of asbestos-abatement techniques. Phase 1. Removal. Final report

    SciTech Connect

    Chesson, J.; Margeson, D.P.; Ogden, J.; Reichenbach, N.G.; Bauer, K.

    1985-10-01

    Airborne asbestos levels were measured by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and phase constrast microscopy (PCM) before, during, and after removal of sprayed-on acoustical plaster from the ceilings of four suburban schools. Air samples were collected at three types of sites: indoor sites with asbestos-containing material (ACM), indoor sites without ACM (indoor control), and sites outside the building (outdoor control). Bulk samples of the ACM were collected prior to the removal and analyzed by polarized light microscopy (PLM). A vigorous quality-assurance program was applied to all aspects of the study. Airborne asbestos levels were low before and after removal. Elevated, but still relatively low levels were measured outside the work area during removal. This emphasizes the need for careful containment of the work area.

  6. Ancient Chinese medical ethics and the four principles of biomedical ethics.

    PubMed Central

    Tsai, D F

    1999-01-01

    The four principles approach to biomedical ethics (4PBE) has, since the 1970s, been increasingly developed as a universal bioethics method. Despite its wide acceptance and popularity, the 4PBE has received many challenges to its cross-cultural plausibility. This paper first specifies the principles and characteristics of ancient Chinese medical ethics (ACME), then makes a comparison between ACME and the 4PBE with a view to testing out the 4PBE's cross-cultural plausibility when applied to one particular but very extensive and prominent cultural context. The result shows that the concepts of respect for autonomy, non-maleficence, beneficence and justice are clearly identifiable in ACME. Yet, being influenced by certain socio-cultural factors, those applying the 4PBE in Chinese society may tend to adopt a "beneficence-oriented", rather than an "autonomy-oriented" approach, which, in general, is dissimilar to the practice of contemporary Western bioethics, where "autonomy often triumphs". PMID:10461594

  7. Progress in BSCCO-2223 tape technology

    NASA Astrophysics Data System (ADS)

    Malozemoff, A. P.; Li, Q.; Fleshler, S.

    1997-08-01

    ASC multifilamentary composite tape based on BSCCO-2223 high temperature superconductor (HTS) and a scalable rolling process has reached a record superconductor critical current density J c (77 K, 0 T) of up to 58,000 A/cm 2, and engineering (full cross-section including metal sheath) J e (77 K, 0 T) up to 15,000 A/cm 2. Pilot manufacturing of long lengths (100-400 m) has permitted a variety of increasingly significant prototypes, including a 200 hp ac synchronous motor, a 3300 A (77 K) 50 m machine-stranded cable conductor, a 5 kJ SMES system, and an operational ion-beam switching magnet installed in a tandem accelerator for carbon mass spectrometry dating. Recent ASC progress in manufacturing with Je over 8000 A/cm 2 creates new opportunities for yet more advanced prototypes and commercial development.

  8. Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera.

    PubMed

    Karaca, K; Sharma, J M; Nordgren, R

    1995-03-01

    Cultures of normal chicken spleen cells and HD11 line cells produce nitric oxide (NO) in response to Acemannan, a complex carbohydrate derived from the Aloe vera plant. Neither cell type produced detectable amounts of NO in response to similar concentrations of yeast mannan, another complex carbohydrate. Nitric oxide production was dose dependent and inhibitable by the nitric oxide synthase inhibitor NG-methyl-L-arginine. In addition, the production of NO was inhibited by preincubation of ACM with concanavalin A in a dose-dependent manner. These results suggest that ACM-induced NO synthesis may be mediated through macrophage mannose receptors, and macrophage activation may be accountable for some of the immunomodulatory effects of ACM in chickens.

  9. An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity Against Diverse Fungal Pathogens

    PubMed Central

    Robbins, Nicole; Spitzer, Michaela; Yu, Tennison; Cerone, Robert P.; Averette, Anna K.; Bahn, Yong-Sun; Heitman, Joseph; Sheppard, Donald C.; Tyers, Mike; Wright, Gerard D.

    2015-01-01

    SUMMARY There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl and cyprodinil with ~3600 compounds in diverse fungal species, we generated a deep reservoir of chemical-chemical interactions termed the Antifungal Combinations Matrix (ACM). Follow-up susceptibility testing against a fluconazole resistant isolate of C. albicans unveiled ACM combinations capable of potentiating fluconazole in this clinical strain. We used chemical genetics to elucidate the mode-of-action of the antimycobacterial drug clofazimine, a compound with unreported antifungal activity that synergized with several antifungals. Clofazimine induces a cell membrane stress for which the Pkc1 signaling pathway is required for tolerance. Further tests against additional fungal pathogens, including Aspergillus fumigatus, highlighted that clofazimine exhibits efficacy as a combination agent against multiple fungi. Thus, the ACM is a rich reservoir of chemical combinations with therapeutic potential against diverse fungal pathogens. PMID:26549450

  10. Preparation and critical current densities of highly textured 2212 BiSrCaCu oxide layers on silver

    NASA Astrophysics Data System (ADS)

    Kress, B.; Neumüller, H. W.; Assmann, H.; Wohlfart, M.; Kase, J.; Kumakura, H.; Togano, K.

    1991-12-01

    Doctor blade processed green tapes and screen printable pastes on silver foil, both prepared with Bi 2Sr 2Ca 1Cu 2O x powder, were subjected to melt-texturing using melting and crystallization temperatures derived from DTA measurements. Highly textured layers were formed by slow cooling from the melting temperature to the crystallization temperature and quenching after a holding period. Quenching increased Tc to 90 K. The critical current density was measured as a function of temperature and magnetic field. At 4.2 K and 77 K and 0 Tesla, critical current densities as high as 1.3 × 10 5 A/cm 2 and 1.04 × 10 4 A/cm 2 were observed, respectively. At 4.2 K and 10 Tesla a critical current density of up to 5 × 10 4 A/cm 2 was obtained, even with B ⊥ tape

  11. Characterization of Protein Flexibility Using Small-Angle X-Ray Scattering and Amplified Collective Motion Simulations

    PubMed Central

    Wen, Bin; Peng, Junhui; Zuo, Xiaobing; Gong, Qingguo; Zhang, Zhiyong

    2014-01-01

    Large-scale flexibility within a multidomain protein often plays an important role in its biological function. Despite its inherent low resolution, small-angle x-ray scattering (SAXS) is well suited to investigate protein flexibility and determine, with the help of computational modeling, what kinds of protein conformations would coexist in solution. In this article, we develop a tool that combines SAXS data with a previously developed sampling technique called amplified collective motions (ACM) to elucidate structures of highly dynamic multidomain proteins in solution. We demonstrate the use of this tool in two proteins, bacteriophage T4 lysozyme and tandem WW domains of the formin-binding protein 21. The ACM simulations can sample the conformational space of proteins much more extensively than standard molecular dynamics (MD) simulations. Therefore, conformations generated by ACM are significantly better at reproducing the SAXS data than are those from MD simulations. PMID:25140431

  12. Manganese transport by rat brain endothelial (RBE4) cell-based transwell model in the presence of astrocyte conditioned media.

    PubMed

    Fitsanakis, Vanessa A; Piccola, Greg; Aschner, Judy L; Aschner, Michael

    2005-07-15

    Manganese (Mn), an essential nutrient, is neurotoxic at high levels and has been associated with the development of a parkinsonian syndrome termed manganism. Currently, the mechanisms responsible for transporting Mn across the blood-brain barrier (BBB) are unknown. By using rat brain endothelial 4 (RBE4) cell monolayers cultured in astrocyte-conditioned media (ACM), we examine the effects of temperature, energy, proton (pH), iron (Fe), and sodium (Na(+)) dependence on Mn transport. Our results suggest that Mn transport is temperature, energy, and pH dependent, but not Fe or Na(+) dependent. These data suggest that Mn transport across the BBB is an active process, but they also demonstrate that the presence of ACM in endothelial cell cultures decreases the permeability of these cells to Mn, reinforcing the use of ACM or astrocyte cocultures in studies examining metal transport across the BBB.

  13. Continuous-wave InAs/GaAs quantum-dot laser diodes monolithically grown on Si substrate with low threshold current densities.

    PubMed

    Lee, Andrew; Jiang, Qi; Tang, Mingchu; Seeds, Alwyn; Liu, Huiyun

    2012-09-24

    We report the first room-temperature continuous-wave operation of III-V quantum-dot laser diodes monolithically grown on a Si substrate. Long-wavelength InAs/GaAs quantum-dot structures were fabricated on Ge-on-Si substrates. Room-temperature lasing at a wavelength of 1.28 μm has been achieved with threshold current densities of 163 A/cm(2) and 64.3 A/cm(2) under continuous-wave and pulsed conditions for ridge-waveguide lasers with as cleaved facets, respectively. The value of 64.3 A/cm(2) represents the lowest room-temperature threshold current density for any kind of laser on Si to date.

  14. Cassini atmospheric chemistry mapper. Volume 1. Investigation and technical plan

    NASA Technical Reports Server (NTRS)

    Smith, William Hayden; Baines, Kevin Hays; Drossart, Pierre; Fegley, Bruce; Orton, Glenn; Noll, Keith; Reitsema, Harold; Bjoraker, Gordon L.

    1990-01-01

    The Cassini Atmospheric Chemistry Mapper (ACM) enables a broad range of atmospheric science investigations for Saturn and Titan by providing high spectral and spatial resolution mapping and occultation capabilities at 3 and 5 microns. ACM can directly address the major atmospheric science objectives for Saturn and for Titan, as defined by the Announcement of Opportunity, with pivotal diagnostic measurements not accessible to any other proposed Cassini instrument. ACM determines mixing ratios for atmospheric molecules from spectral line profiles for an important and extensive volume of the atmosphere of Saturn (and Jupiter). Spatial and vertical profiles of disequilibrium species abundances define Saturn's deep atmosphere, its chemistry, and its vertical transport phenomena. ACM spectral maps provide a unique means to interpret atmospheric conditions in the deep (approximately 1000 bar) atmosphere of Saturn. Deep chemistry and vertical transport is inferred from the vertical and horizontal distribution of a series of disequilibrium species. Solar occultations provide a method to bridge the altitude range in Saturn's (and Titan's) atmosphere that is not accessible to radio science, thermal infrared, and UV spectroscopy with temperature measurements to plus or minus 2K from the analysis of molecular line ratios and to attain an high sensitivity for low-abundance chemical species in the very large column densities that may be achieved during occultations for Saturn. For Titan, ACM solar occultations yield very well resolved (1/6 scale height) vertical mixing ratios column abundances for atmospheric molecular constituents. Occultations also provide for detecting abundant species very high in the upper atmosphere, while at greater depths, detecting the isotopes of C and O, constraining the production mechanisms, and/or sources for the above species. ACM measures the vertical and horizontal distribution of aerosols via their opacity at 3 microns and, particularly, at 5

  15. Cardiovascular Comorbidity and Mortality in Men With Prostate Cancer Treated With Brachytherapy-Based Radiation With or Without Hormonal Therapy

    SciTech Connect

    Nanda, Akash; Chen, Ming-Hui; Moran, Brian J.; Braccioforte, Michelle H.; D'Amico, Anthony V.

    2013-04-01

    Purpose: To assess the impact of coronary artery disease (CAD) risk factors and sequelae on the risk of all-cause mortality (ACM) in men treated for prostate cancer (PC). Methods and Materials: The study cohort comprised 5077 men with PC consecutively treated with curative intent between 1997 and 2006 at the Chicago Prostate Cancer Center. Cox and Fine and Gray's competing risks regression multivariable analyses were performed, assessing whether cardiovascular comorbidity impacted the risk of ACM and PC-specific mortality, respectively, adjusting for CAD risk factors (diabetes mellitus, hypercholesterolemia, or hypertension) and sequelae (congestive heart failure or myocardial infarction), age, year and type of treatment, and known PC prognostic factors. Results: When compared with men with no comorbidity there was a significantly increased risk of ACM in men with congestive heart failure or myocardial infarction (adjusted hazard ratio [AHR] 1.96, P<.001) and in men with diabetes mellitus (AHR 1.60, P=.03) and hypertension (AHR 1.25, P=.04). In contrast, men with hypercholesterolemia had a similar risk of ACM (AHR 0.68, P=.17) when compared with men with no comorbidity. Other factors associated with a significantly increased risk of ACM included age (AHR 1.09, P<.001), prostate-specific antigen level (AHR 1.25, P=.008), and Gleason score 8-10 disease (AHR 1.71, P=.003). Cardiovascular comorbidity did not impact the risk of PC-specific mortality. Conclusions: In addition to age and unfavorable PC prognostic factors, select CAD risk factors and sequelae are associated with an increased risk of ACM in men treated for PC. These comorbidity prognostic factors predict time courses of mortality from competing causes, which may be factored into the decision-making process when considering management options for PC in a given individual.

  16. Management of parturients in active labor with Arnold Chiari malformation, tonsillar herniation, and syringomyelia

    PubMed Central

    Ghaly, Ramsis F.; Tverdohleb, Tatiana; Candido, Kenneth D.; Knezevic, Nebojsa Nick

    2017-01-01

    Background: Arnold-Chiari malformation Type 1 (ACM-1) in parturients is a topic of ongoing discussion between obstetricians and anesthesiologists. The primary unanswered question remains; How should the anesthesia provider proceed with labor analgesia and anesthesia for cesarean section when confronted with an advanced, asymptomatic, or minimally symptomatic case of ACM-1 during labor? Case Description: A 24-year-old, ASA II, G1P0 full-term parturient presented to Labor and Delivery for vaginal delivery. A diagnosis of ACM-1 was made 12 years ago when a brain magnetic resonance imaging (MRI) was performed for right-sided numbness following a rear-end motor vehicle collision. The patient had been asymptomatic since then and had been seen by an outside neurologist frequently for the past 10 years. During the anesthesia evaluation, it was noted that she had an exaggerated patellar reflex, and a questionable left-sided Babinski; subsequently, an MRI study was requested. Review of a brain MRI demonstrated an advanced form of ACM with a 1.7 cm transtonsillar herniation and a large syrinx extending from C1 down to C5. Following a discussion with the patient, family, and primary OB team, a plan for elective cesarean section was made per neurosurgical recommendations. This was conducted uneventfully under general anesthesia. The patient had no complaints in the post-anesthesia care unit. Conclusion: Unfamiliarity of health care providers with regards to ACM-1 parturients can be countered by increasing awareness of this condition throughout medical specialties involved in their care. The Ghaly Obstetric Guide to Arnold-Chiari malformation Type 1, along with proper training of anesthesia care providers regarding the specificities of ACM-1 parturients aids in better management and understanding of this complex condition. PMID:28217389

  17. Protective effect of Amorphophallus campanulatus (Roxb.) Blume. tuber against thioacetamide induced oxidative stress in rats.

    PubMed

    Ansil, Puthuparampil Nazarudeen; Nitha, Anand; Prabha, Santhibhavan Prabhakaran; Wills, Pallara Janardhanan; Jazaira, Vahab; Latha, Mukalel Sankunni

    2011-11-01

    To identify the phytochemical constituents of Amorphophallus campanulatus (A. campanulatus) tuber and to evaluate its antioxidant potential through in vitro and in vivo models. Phytochemical screening and in vitro antioxidant activities of A. campanulatus tuber n-hexane extract (ACHE) and methanolic extract (ACME) were evaluated using DPPH, hydroxyl radical, reducing power and total antioxidant capacity assays. The total phenolic and flavonoid contents were also investigated. The protective potential of two different doses of ACME (125 and 250 mg/kg) was also evaluated against thioacetamide (TAA) induced oxidative stress in rats. Silymarin used as a standard drug control. Hepatotoxicity was assessed by quantifying the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The antioxidant potential of ACME were also evaluated by the estimation of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (Thiobarbituric acid reactive substances) in hepatic and renal tissues. Histopathologic changes of liver were also evaluated. In vitro studies revealed that ACME has higher antioxidant and radical scavenging activity than ACHE, which may be attributed to its higher phenolic and flavonoid content. ACME significantly prevented the elevation of serum AST, ALT, ALP, LDH, and tissue malondialdehyde levels(P < 0.05). Hepatic and renal GSH, GST, GR, GPx, and catalase levels were remarkably increased by the treatment with the extract. Quantification of histopathological changes also supported the dose dependent protective effects of ACME. The results do suggest that A. campanulatus tuber could be considered as a potential source of natural antioxidant. Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  18. Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

    PubMed Central

    Rojas, Fabiola; Cortes, Nicole; Abarzua, Sebastian; Dyrda, Agnieszka; van Zundert, Brigitte

    2013-01-01

    Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction and degeneration of motor neurons. Multiple disease-causing mutations, including in the genes for SOD1 and TDP-43, have been identified in ALS. Astrocytes expressing mutant SOD1 are strongly implicated in the pathogenesis of ALS: we have shown that media conditioned by astrocytes carrying mutant SOD1G93A contains toxic factor(s) that kill motoneurons by activating voltage-sensitive sodium (Nav) channels. In contrast, a recent study suggests that astrocytes expressing mutated TDP43 contribute to ALS pathology, but do so via cell-autonomous processes and lack non-cell-autonomous toxicity. Here we investigate whether astrocytes that express diverse ALS-causing mutations release toxic factor(s) that induce motoneuron death, and if so, whether they do so via a common pathogenic pathway. We exposed primary cultures of wild-type spinal cord cells to conditioned medium derived from astrocytes (ACM) that express SOD1 (ACM-SOD1G93A and ACM-SOD1G86R) or TDP43 (ACM-TDP43A315T) mutants; we show that such exposure rapidly (within 30–60 min) increases dichlorofluorescein (DCF) fluorescence (indicative of nitroxidative stress) and leads to extensive motoneuron-specific death within a few days. Co-application of the diverse ACMs with anti-oxidants Trolox or esculetin (but not with resveratrol) strongly improves motoneuron survival. We also find that co-incubation of the cultures in the ACMs with Nav channel blockers (including mexiletine, spermidine, or riluzole) prevents both intracellular nitroxidative stress and motoneuron death. Together, our data document that two completely unrelated ALS models lead to the death of motoneuron via non-cell-autonomous processes, and show that astrocytes expressing mutations in SOD1 and TDP43 trigger such cell death through a common pathogenic pathway that involves nitroxidative stress, induced at least in part by Nav channel activity. PMID:24570655

  19. Electrochemical impedance spectroscopy study of carbon electrodes prepared from date pits and fibers of oil palm empty fruit bunches

    NASA Astrophysics Data System (ADS)

    Hamdan, E.; Deraman, M.; Suleman, M.; Nor, N. S. M.; Basri, N. H.; Hanappi, M. F. Y. M.; Sazali, N. E. S.; Tajuddin, N. S. M.; Omar, R.; Othman, M. A. R.; Shamsudin, S. A.

    2016-11-01

    In this study, we produced pre-carbonized date pits (PDP) and self-adhesive carbon grains (SACGs) from oil palm empty fruit bunches (EFB) by a low temperature (200°C for DP and 280°C for SACGs, respectively) carbonization method followed by KOH treatment to obtain KOH treated PDP (T-PDP) and KOH treated SACGs (T-SACGs). Four sets of green monolith (GMs) denoted as GM-A, GM-B, GM-C and GM-D were prepared respectively from SACGs (100 wt. %), mixture of PDP and SACGs (50:50 wt. %), T-SACGs (100 wt. %), and mixture of T-SACGs and T-PDP (50:50 wt. %), respectively. From these GMs the respective activated carbon monolith (ACMs) electrodes namely ACM-A, ACM-B, ACM-C and ACM-D were prepared via carbonization (N2 carbonization) and activation (CO2 environment). These ACMs electrodes were used to fabricate the corresponding EDLC cells: Cell-A, Cell-B, Cell-C and Cell-D, respectively. The electrochemical impedance spectroscopy tests conducted on the cells found that the Cell-D showed the maximum value of specific capacitance, Csp (˜ 135 F g-1) whereas the Cell-A showed the minimum values of ESR and characteristic response time, respectively, ˜ 2.14 Ω and ˜ 46 s. Therefore, it can be concluded that the KOH treatment can improve the capacitance but caused the increase in the ESR and response time.

  20. Structural health monitoring of wind turbine blades : SE 265 Final Project.

    SciTech Connect

    Barkley, W. C.; Jacobs, Laura D.; Rutherford, A. C.; Puckett, Anthony

    2006-03-23

    ACME Wind Turbine Corporation has contacted our dynamic analysis firm regarding structural health monitoring of their wind turbine blades. ACME has had several failures in previous years. Examples are shown in Figure 1. These failures have resulted in economic loss for the company due to down time of the turbines (lost revenue) and repair costs. Blade failures can occur in several modes, which may depend on the type of construction and load history. Cracking and delamination are some typical modes of blade failure. ACME warranties its turbines and wishes to decrease the number of blade failures they have to repair and replace. The company wishes to implement a real time structural health monitoring system in order to better understand when blade replacement is necessary. Because of warranty costs incurred to date, ACME is interested in either changing the warranty period for the blades in question or predicting imminent failure before it occurs. ACME's current practice is to increase the number of physical inspections when blades are approaching the end of their fatigue lives. Implementation of an in situ monitoring system would eliminate or greatly reduce the need for such physical inspections. Another benefit of such a monitoring system is that the life of any given component could be extended since real conditions would be monitored. The SHM system designed for ACME must be able to operate while the wind turbine is in service. This means that wireless communication options will likely be implemented. Because blade failures occur due to cyclic stresses in the blade material, the sensing system will focus on monitoring strain at various points.

  1. Interleukin-4, interleukin-10, and interleukin-1-receptor antagonist but not transforming growth factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells.

    PubMed

    Wirjatijasa, Florentina; Dehghani, Faramarz; Blaheta, Roman A; Korf, Horst-Werner; Hailer, Nils P

    2002-06-01

    The activity of microglial cells is strictly controlled in order to maintain central nervous system (CNS) immune privilege. We hypothesized that several immunomodulatory factors present in the CNS parenchyma, i.e., the Th2-derived cytokines interleukin (IL)-4 and IL-10, interleukin-1-receptor-antagonist (IL-1-ra), or transforming growth factor (TGF)-beta can modulate microglial morphology and functions. Microglial cells were incubated with IL-4, IL-10, IL-1-ra, TGF-beta, or with astrocyte conditioned media (ACM) and were analyzed for morphological changes, expression of intercellular adhesion molecule (ICAM)-1, and secretion of IL-1beta or tumor necrosis factor (TNF)-alpha. Whereas untreated controls showed an amoeboid morphology both Th2-derived cytokines, IL-1-ra, and ACM induced a morphological transformation to the ramified phenotype. In contrast, TGF-beta-treated microglial cells showed an amoeboid morphology. Even combined with the neutralizing antibodies against IL-4, IL-10, or TGF-beta ACM induced microglial ramification. Furthermore, ACM did not contain relevant amounts of IL-4 and IL-10, as measured by enzyme-linked immunosorbent assay (ELISA). Flow cytometry showed that lipopolysaccharide (LPS)-induced ICAM-1-expression on microglial cells was strongly suppressed by ACM, significantly modulated by IL-4, IL-10, or IL-1-ra, but not influenced by TGF-beta. The LPS-induced secretion of IL-1beta and TNF-alpha was only reduced after application of ACM, whereas IL-4 or IL-10 did not inhibit IL-1beta- or TNF-alpha secretion. TGF-beta enhanced IL-1beta- but not TNF-alpha secretion. In summary, we demonstrate that IL-4, IL-10, and IL-1-ra induce microglial ramification and reduce ICAM-1-expression, whereas the secretion of proinflammatory cytokines is not prevented. TGF-beta has no modulating effects. Importantly, unidentified astrocytic factors that are not identical with IL-4, IL-10, or TGF-beta possess strong immunomodulatory properties.

  2. Application of Antidromic Conduction Monitoring in Ganglion Radiofrequency Thermocoagulation for Locating Trigeminal Branches in Trigeminal Neuralgia.

    PubMed

    Li, Xiuhua; Yue, Jianning; Yang, Liqiang; Yang, Huijie; Zheng, Shuyue; He, Liangliang; Ni, Jiaxiang

    2016-03-01

    The aim of this study was to investigate whether antidromic conduction monitoring (ACM) can be utilized to map the trigeminal system under sedation as a potential substitute for subjective paresthesia description (SPD) during percutaneous ganglion radiofrequency thermocoagulation (PGRT). Eighty-two patients with 152 pain divisions of trigeminal neuralgia (TN) were treated by computed tomography (CT)-guided PGRT. After the puncture needle entered the foramen ovale (FO), sensory and motor stimulation were applied to locate the pain division. And the corresponding voltage values were recorded by patients' SPD. In the following, the proper location was certified by ACM. The corresponding earliest waves and voltage values in the identified trigeminal branch were also recorded to outline a comparison between two methods. The correlation of ACM and patients' SPD with voltage at ≤ 0.5 V was statistically significant (P < 0.05, r = 0.159; Spearman's rank correlation analysis). Although ACM and SPD showed weak correlation, as their interclass correlation coefficient was significant (F = 1.868, P < 0.01) with coefficient of internal consistency. Moreover, the two methods had consistency. Kruskal-Wallis test showed that ophthalmic (V1), maxillary (V2), and mandibular (V3) divisions had significant differences for test sensitivity (H = 15.945, P < 0.01). For comparison of sensitivities with ACM, V3 was most sensitive followed by V2 and then V1. ACM could potentially substitute for SPD of the paresthesias intra-operatively, enabling greater specificity and eliminating the need to interrupt the administration of anesthetic. These improvements would increase patient satisfaction and practitioner efficiency and accuracy. © 2015 World Institute of Pain.

  3. [Removal of fluorescent whitening agent by hydrogen peroxide oxidation catalyzed by activated carbon].

    PubMed

    Liu, Hai-Long; Zhang, Zhong-Min; Zhao, Xia; Jiao, Ru-Yuan

    2014-06-01

    Degradation of fluorescent whitening agent VBL in the processes of activated carbon (AC) and activated carbon modified (ACM) adsorptions, hydrogen peroxide (H2O2) oxidation, and hydrogen peroxide oxidation catalyzed by activated carbon were studied. Mechanism of the above catalytic oxidation was also investigated by adding tert-Butyl alcohol (TBA), the free radical scavenger, and detecting the released gases. The results showed that: the activated carbon modified by Fe (NO3)3 (ACM)exhibited better adsorption removal than AC. Catalytic oxidation showed efficient removal of VBL, and the catalytic removal of AC (up to 95%) was significantly higher than that of ACM (58% only). Catalytic oxidation was inhibited by TBA, which indicates that the above reaction involved *OH radicals and atom oxygen generated by hydrogen peroxide with the presence of AC. The results of H2O2 decomposition and released gases detection involved in the process showed that activated carbon enhanced the decomposition of H2O2 which released oxygen and heat. More O2 was produced and higher temperature of the reactor was achieved, which indicated that H2O2 decomposition catalyzed by ACM was significantly faster than that of AC. Combining the results of VBL removal, it could be concluded that the rate of active intermediates (*OH radicals and atom oxygen) production by ACM catalytic reaction was faster than that of AC. These intermediates consumed themselves and produced O2 instead of degrading VBL. It seemed that the improper mutual matching of the forming rate of activating intermediates and the supply rate of reactants was an important reason for the lower efficiency of ACM catalytic reaction comparing with AC.

  4. MO-F-CAMPUS-I-04: Magnetic Resonance Imaging of An in Vitro 3D Tumor Model

    SciTech Connect

    Veiga, C; Long, T; Siow, B; Loizidou, M; Royle, G; Ricketts, K

    2015-06-15

    Purpose: To investigate the use of an in vitro 3D tumor model (tumoroid) as a bio-phantom for repetitive and sequential magnetic resonance imaging (MRI) studies. Methods: The tissue engineered tumoroid comprised an artificial cancer mass (ACM) containing 30 million HT29 cancer cells seeded in a collagen type I matrix, whose density was increased by plastic compression (dry/wet weight=40%). The ACM was embedded in an uncompressed collagen gel that mimicked the tumor stroma, and the tumoroid was incubated for 24h before imaging. Images were acquired using the 1T ICON™ (Bruker Corporation, Billerica, MA) MRI scanner. T1 maps were calculated using an IR-RARE sequence (TE=12ms, TR=10000ms, 7 inversion times), while for T2 maps a MSME technique (TR=6000ms, 16 echoes) was used. T1 and T2 fittings were performed using a pixel-wise approach to produce relaxometric parametric maps. Results: The images acquired and corresponding T1 and T2 maps indicate contrast between the ACM and the stroma. T1 was 2500 and 2800ms, while T2 was 520 and 760ms, for the ACM and stroma respectively. The ACM construct was not homogenous and internal features were visible, which can be explained by local gradients of cell and/or collagen density. The viability of the cells was confirmed via confocal microscopy for several days after the imaging session, demonstrating the suitability of the tumoroid for sequential imaging studies. Conclusions: We have engineered a tumor model compatible with repetitive and sequential MRI. We found T1 and T2 contrast between the ACM and stroma using a pre-clinical MRI scanner. The model, which enables controllable cell and matrix densities, has potential for a wide range of applications in radiotherapy, such as to study tumor progression and to validate imaging biomarkers. Further work is necessary to understand the mechanisms behind the contrast achieved, and to correlate findings with biology and histology data.

  5. A Computing Cluster for Numerical Simulation

    DTIC Science & Technology

    2006-10-23

    34Contact and Friction for Cloth Animation", SIGGRAPH 2002, ACM TOG 21, 594-603 (2002). "* [BHTF] Bao, Z., Hong, J.-M., Teran , J. and Fedkiw, R...Simulation of Large Bodies of Water by Coupling Two and Three Dimensional Techniques", SIGGRAPH 2006, ACM TOG 25, 805-811 (2006). "* [ITF] Irving, G., Teran ...O’Brien (2006) "* [TSBNLF] Teran , J., Sifakis, E., Blemker, S., Ng Thow Hing, V., Lau, C. and Fedkiw, R., "Creating and Simulating Skeletal Muscle from the

  6. Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling

    PubMed Central

    Rojas, Fabiola; Gonzalez, David; Cortes, Nicole; Ampuero, Estibaliz; Hernández, Diego E.; Fritz, Elsa; Abarzua, Sebastián; Martinez, Alexis; Elorza, Alvaro A.; Alvarez, Alejandra; Court, Felipe; van Zundert, Brigitte

    2015-01-01

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which pathogenesis and death of motor neurons are triggered by non-cell-autonomous mechanisms. We showed earlier that exposing primary rat spinal cord cultures to conditioned media derived from primary mouse astrocyte conditioned media (ACM) that express human SOD1G93A (ACM-hSOD1G93A) quickly enhances Nav channel-mediated excitability and calcium influx, generates intracellular reactive oxygen species (ROS), and leads to death of motoneurons within days. Here we examined the role of mitochondrial structure and physiology and of the activation of c-Abl, a tyrosine kinase that induces apoptosis. We show that ACM-hSOD1G93A, but not ACM-hSOD1WT, increases c-Abl activity in motoneurons, interneurons and glial cells, starting at 60 min; the c-Abl inhibitor STI571 (imatinib) prevents this ACM-hSOD1G93A-mediated motoneuron death. Interestingly, similar results were obtained with ACM derived from astrocytes expressing SOD1G86R or TDP43A315T. We further find that co-application of ACM-SOD1G93A with blockers of Nav channels (spermidine, mexiletine, or riluzole) or anti-oxidants (Trolox, esculetin, or tiron) effectively prevent c-Abl activation and motoneuron death. In addition, ACM-SOD1G93A induces alterations in the morphology of neuronal mitochondria that are related with their membrane depolarization. Finally, we find that blocking the opening of the mitochondrial permeability transition pore with cyclosporine A, or inhibiting mitochondrial calcium uptake with Ru360, reduces ROS production and c-Abl activation. Together, our data point to a sequence of events in which a toxic factor(s) released by ALS-expressing astrocytes rapidly induces hyper-excitability, which in turn increases calcium influx and affects mitochondrial structure and physiology. ROS production, mediated at least in part through mitochondrial alterations, trigger c-Abl signaling and lead to motoneuron death. PMID:26106294

  7. Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling.

    PubMed

    Rojas, Fabiola; Gonzalez, David; Cortes, Nicole; Ampuero, Estibaliz; Hernández, Diego E; Fritz, Elsa; Abarzua, Sebastián; Martinez, Alexis; Elorza, Alvaro A; Alvarez, Alejandra; Court, Felipe; van Zundert, Brigitte

    2015-01-01

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which pathogenesis and death of motor neurons are triggered by non-cell-autonomous mechanisms. We showed earlier that exposing primary rat spinal cord cultures to conditioned media derived from primary mouse astrocyte conditioned media (ACM) that express human SOD1(G93A) (ACM-hSOD1(G93A)) quickly enhances Nav channel-mediated excitability and calcium influx, generates intracellular reactive oxygen species (ROS), and leads to death of motoneurons within days. Here we examined the role of mitochondrial structure and physiology and of the activation of c-Abl, a tyrosine kinase that induces apoptosis. We show that ACM-hSOD1(G93A), but not ACM-hSOD1(WT), increases c-Abl activity in motoneurons, interneurons and glial cells, starting at 60 min; the c-Abl inhibitor STI571 (imatinib) prevents this ACM-hSOD1(G93A)-mediated motoneuron death. Interestingly, similar results were obtained with ACM derived from astrocytes expressing SOD1(G86R) or TDP43(A315T). We further find that co-application of ACM-SOD1(G93A) with blockers of Nav channels (spermidine, mexiletine, or riluzole) or anti-oxidants (Trolox, esculetin, or tiron) effectively prevent c-Abl activation and motoneuron death. In addition, ACM-SOD1(G93A) induces alterations in the morphology of neuronal mitochondria that are related with their membrane depolarization. Finally, we find that blocking the opening of the mitochondrial permeability transition pore with cyclosporine A, or inhibiting mitochondrial calcium uptake with Ru360, reduces ROS production and c-Abl activation. Together, our data point to a sequence of events in which a toxic factor(s) released by ALS-expressing astrocytes rapidly induces hyper-excitability, which in turn increases calcium influx and affects mitochondrial structure and physiology. ROS production, mediated at least in part through mitochondrial alterations, trigger c-Abl signaling and lead to motoneuron death.

  8. Quantification of mitral regurgitation by automated cardiac output measurement: experimental and clinical validation

    NASA Technical Reports Server (NTRS)

    Sun, J. P.; Yang, X. S.; Qin, J. X.; Greenberg, N. L.; Zhou, J.; Vazquez, C. J.; Griffin, B. P.; Stewart, W. J.; Thomas, J. D.

    1998-01-01

    OBJECTIVES: To develop and validate an automated noninvasive method to quantify mitral regurgitation. BACKGROUND: Automated cardiac output measurement (ACM), which integrates digital color Doppler velocities in space and in time, has been validated for the left ventricular (LV) outflow tract but has not been tested for the LV inflow tract or to assess mitral regurgitation (MR). METHODS: First, to validate ACM against a gold standard (ultrasonic flow meter), 8 dogs were studied at 40 different stages of cardiac output (CO). Second, to compare ACM to the LV outflow (ACMa) and inflow (ACMm) tracts, 50 normal volunteers without MR or aortic regurgitation (44+/-5 years, 31 male) were studied. Third, to compare ACM with the standard pulsed Doppler-two-dimensional echocardiographic (PD-2D) method for quantification of MR, 51 patients (61+/-14 years, 30 male) with MR were studied. RESULTS: In the canine studies, CO by ACM (1.32+/-0.3 liter/min, y) and flow meter (1.35+/-0.3 liter/min, x) showed good correlation (r=0.95, y=0.89x+0.11) and agreement (deltaCO(y-x)=0.03+/-0.08 [mean+/-SD] liter/min). In the normal subjects, CO measured by ACMm agreed with CO by ACMa (r=0.90, p < 0.0001, deltaCO=-0.09+/-0.42 liter/min), PD (r=0.87, p < 0.0001, deltaCO=0.12+/-0.49 liter/min) and 2D (r=0.84, p < 0.0001, deltaCO=-0.16+/-0.48 liter/min). In the patients, mitral regurgitant volume (MRV) by ACMm-ACMa agreed with PD-2D (r= 0.88, y=0.88x+6.6, p < 0.0001, deltaMRV=2.68+/-9.7 ml). CONCLUSIONS: We determined that ACM is a feasible new method for quantifying LV outflow and inflow volume to measure MRV and that ACM automatically performs calculations that are equivalent to more time-consuming Doppler and 2D measurements. Additionally, ACM should improve MR quantification in routine clinical practice.

  9. Study of a very low cost air combat maneuvering trainer aircraft

    NASA Technical Reports Server (NTRS)

    Hill, G. C.; Bowles, J. V.

    1976-01-01

    A very low cost aircraft for performing Air Combat Maneuvering (ACM) training was studied using the BD-5J sport plane as a point of departure. The installation of a larger engine and increased fuel capacity were required to meet the performance and mission objectives. Reduced wing area increased the simulation of the ACM engagement, and a comparison with current tactical aircraft is presented. Other factors affecting the training transfer are considered analytically, but a flight evaluation is recommended to determine the concept utility.

  10. An extended doubly-adaptive quadrature method based on the combination of the Ninomiya and the FLR schemes

    NASA Astrophysics Data System (ADS)

    Hasegawa, Takemitsu; Hibino, Susumu; Hosoda, Yohsuke; Ninomiya, Ichizo

    2007-08-01

    An improvement is made to an automatic quadrature due to Ninomiya (J. Inf. Process. 3:162?170, 1980) of adaptive type based on the Newton?Cotes rule by incorporating a doubly-adaptive algorithm due to Favati, Lotti and Romani (ACM Trans. Math. Softw. 17:207?217, 1991; ACM Trans. Math. Softw. 17:218?232, 1991). We compare the present method in performance with some others by using various test problems including Kahaner?s ones (Computation of numerical quadrature formulas. In: Rice, J.R. (ed.) Mathematical Software, 229?259. Academic, Orlando, FL, 1971).

  11. Assumptions, Trust, and Names in Computer Security Protocols

    DTIC Science & Technology

    2011-06-01

    some of these issues in Section 2.3.) Quine expands his approach in [28]. In [29], Kaplan compares the approaches of Frege and Quine and then attempts...according to Kaplan), the second occurrence of ‘Ortcutt’ does not mean anything, at least as far as logic is concerned. But for Frege , the second occurrence...6th ACM Conference on Computer and Communications Security (CCS ’99). ACM, 1999, pp. 52–62. [25] G. Frege , “Über sinn und bedeutung,” Zeitschrift für

  12. Databases in Healthcare.

    DTIC Science & Technology

    1980-03-01

    34; Proc. ACM Pacific 75 Conference, Boole and Babbage , Palo Alto, CA., 1975. Giebin75 Giebink, G.A., et al: "Current Status of Ambulatory Health Care...13, pp. 36-49, 1978. Stimso78 Stimson, D.H. and G. Charles : "A Computer-Based Information System in an Ambulatory Care System and Case Study" Proc...Base Management Systems" Proc. ACM Pacific 75 Conference, Boole and Babbage , Palo Alto, CA, 1975. Szolov78 Szolovits, P. and S.G. Pauker: "Categorical

  13. Experimental investigation of electron guns for THz microwave vacuum amplifiers

    NASA Astrophysics Data System (ADS)

    Burtsev, A. A.; Grigor'ev, Yu. A.; Navrotsky, I. A.; Rogovin, V. I.; Sakhadzhi, G. V.; Shumikhin, K. V.

    2016-05-01

    Single-sheet and multiple beam electron emitters based on thermionic minicathodes for terahertz traveling-wave tubes have been studied. Data are presented for impregnated blade thermionic cathode with dimensions 0.1 × 0.7 mm and a maximum current density of 114 A/cm2 in a pulsed mode. A variant of the five-beam electron gun with 0.25-mm-diameter cylindrical minicathodes in cells of a control grid is proposed that provides a current density of 85.5 A/cm2 at a grid potential of 900-1000 V.

  14. Efficacy of Floor Control Protocols in Distributed Multimedia Collaboration

    DTIC Science & Technology

    1999-01-01

    collaborative design: Agents and emergence. Comm. of the ACM, 37(7):41{47, July 1994. [13] C . A. Ellis, S . J. Gibbs, and G. L. Rein. Groupware - some issues and...experiences. Comm. of the ACM, 34(1):38{58, Jan. 1991. [14] S . Floyd, V. Jacobson, S . McCanne, C .-G. Liu, and L. Zhang. A reliable multicast frame...Networking, San Jose, CA, Feb. 1995. [26] S . Paul, K. K. Sabnani, J. C .-H. Lin, and S . Bhattacharyya. Reliable multicast transport protocol (RMTP). IEEE

  15. Quantification of mitral regurgitation by automated cardiac output measurement: experimental and clinical validation

    NASA Technical Reports Server (NTRS)

    Sun, J. P.; Yang, X. S.; Qin, J. X.; Greenberg, N. L.; Zhou, J.; Vazquez, C. J.; Griffin, B. P.; Stewart, W. J.; Thomas, J. D.

    1998-01-01

    OBJECTIVES: To develop and validate an automated noninvasive method to quantify mitral regurgitation. BACKGROUND: Automated cardiac output measurement (ACM), which integrates digital color Doppler velocities in space and in time, has been validated for the left ventricular (LV) outflow tract but has not been tested for the LV inflow tract or to assess mitral regurgitation (MR). METHODS: First, to validate ACM against a gold standard (ultrasonic flow meter), 8 dogs were studied at 40 different stages of cardiac output (CO). Second, to compare ACM to the LV outflow (ACMa) and inflow (ACMm) tracts, 50 normal volunteers without MR or aortic regurgitation (44+/-5 years, 31 male) were studied. Third, to compare ACM with the standard pulsed Doppler-two-dimensional echocardiographic (PD-2D) method for quantification of MR, 51 patients (61+/-14 years, 30 male) with MR were studied. RESULTS: In the canine studies, CO by ACM (1.32+/-0.3 liter/min, y) and flow meter (1.35+/-0.3 liter/min, x) showed good correlation (r=0.95, y=0.89x+0.11) and agreement (deltaCO(y-x)=0.03+/-0.08 [mean+/-SD] liter/min). In the normal subjects, CO measured by ACMm agreed with CO by ACMa (r=0.90, p < 0.0001, deltaCO=-0.09+/-0.42 liter/min), PD (r=0.87, p < 0.0001, deltaCO=0.12+/-0.49 liter/min) and 2D (r=0.84, p < 0.0001, deltaCO=-0.16+/-0.48 liter/min). In the patients, mitral regurgitant volume (MRV) by ACMm-ACMa agreed with PD-2D (r= 0.88, y=0.88x+6.6, p < 0.0001, deltaMRV=2.68+/-9.7 ml). CONCLUSIONS: We determined that ACM is a feasible new method for quantifying LV outflow and inflow volume to measure MRV and that ACM automatically performs calculations that are equivalent to more time-consuming Doppler and 2D measurements. Additionally, ACM should improve MR quantification in routine clinical practice.

  16. Development of Axial Continuous Metal Expeller for melt conditioning of alloys

    NASA Astrophysics Data System (ADS)

    Cassinath, Z.; Prasada Rao, A. K.

    2016-02-01

    ACME (Axial, centrifugal metal expeller) is a novel processing technology developed independently for conditioning liquid metal prior to solidification processing. The ACME process is based on an axial compressor and uses a rotor stator mechanism to impose a high shear rate and a high intensity of turbulence to the liquid metal, so that the conditioned liquid metal has uniform temperature and uniform chemical composition as it is expelled. The microstructural refinement is achieved through the process of dendrite fragmentation while taking advantage of the thixotropic property of semisolid metal slurry so that it can be conveyed for further downstream operations. This paper introduces the concept and its advantages over current technologies.

  17. Asbestos/NESHAP adequately wet guidance

    SciTech Connect

    Shafer, R.; Throwe, S.; Salgado, O.; Garlow, C.; Hoerath, E.

    1990-12-01

    The Asbestos NESHAP requires facility owners and/or operators involved in demolition and renovation activities to control emissions of particulate asbestos to the outside air because no safe concentration of airborne asbestos has ever been established. The primary method used to control asbestos emissions is to adequately wet the Asbestos Containing Material (ACM) with a wetting agent prior to, during and after demolition/renovation activities. The purpose of the document is to provide guidance to asbestos inspectors and the regulated community on how to determine if friable ACM is adequately wet as required by the Asbestos NESHAP.

  18. Biostratigraphy and assemblage evolution in Planktic Foraminifera across the Cretaceous-Paleogene transition in low latitude, northern and southern Tethys realm: El Kef GSSP, Elles (Tunisia) and Agost, Caravaca (Betic Cordillera, Spain)

    NASA Astrophysics Data System (ADS)

    Gallala, N.; Zaghbib-Turki, D.; Turki, M. M.; Arenillas, I.; Arz, J. A.; Molina, E.

    2009-04-01

    The detailed planktic foraminiferal biostratigraphic and quantitative study from the Cretaceous-Paleogene (K-Pg) transition interval of the most expanded and continuous sections located in Spanish (Agost, Caravaca) and Tunisian sections (El Kef and Ellès), allows us to establish the zonation and subzonation of this interval and to distinguish four Acme-stages across the K/Pg transition interval of these low latitude sections. The uppermost Maastrichtian in Tunisian and Spanish sections, is characterized by standard planktic foraminiferal zones: Abathomphalus mayaroensis subdivided into Plummerita hantkeninoides Subzones. This index species is absent at middle and high-latitude twice in Atlantic and Antarctic oceans. Consequently, this species is considered to be restricted to the tropical and subtropical deep seawater. The lower Danian is characterized by Guembelitria cretacea, Parvularugoglobigerina eugubina, and Parasubbotina pseudobulloides biozones. The Guembelitria cretacea Zone was subdivided into the Hedbergella holmdelensis and Parvularugoglobigerina longiapertura Subzones; the Parvularugoglobigerina eugubina Zone into the Parvularugoglobigerina sabina and Eoglobigerina simplicissima Subzones; and the Parasubbotina pseudobulloides Zone into the Eoglobigerina trivialis and Subbotina triloculinoides Subzones. These zones and subzones are less expanded at the Caravaca and Agost sections than in Tunisian sections: El Kef (Global Stratotype Section and Point for the K/Pg) and Ellès, but it is sufficiently expanded to analyze correctly the planktic foraminiferal assemblage evolution across the K-Pg transition. Across this transition, at the Tethys area, we have identified four Acme-stages: Acme-stage 0: is typical of the upper Maastrichtian interval is dominated by cosmopolitan species dwelling surface and intermediate seawater. Acme-stage 1: is typical of the G. cretacea Zone and is dominated by Guembelitria species belonging to "Cretaceous survivors" species

  19. Development of a Visual System Interface to Support a Domain-Oriented Application Composition System

    DTIC Science & Technology

    1993-03-23

    Spencer. "Coming to Terms with Software Reuse: A Model-based Approach," ACM SIGSOFT Software Engineering Notes, 16:45-51 (April 1991). 36. Prieto ...Dfaz, Ruben. "Domain Analysis: An Introduction," ACM SIGSOFT Software Engi- neering Notes, 15:47-54 (April 1990). 37. Prieto -Daz, RubGn. "Domain Analysis...and Cybernetics, 18:61-79 (January/February 1988). 48. Teague, Alan H. and Henson Graves. lhe Graphi,-4l System Description Language and De- velopment

  20. Thick YBa2Cu3O7-x BaSnO3 Films with Enhanced Critical Current Density at High Magnetic Fields

    DTIC Science & Technology

    2008-10-01

    thick YBCO +BSO film had a Jc ~3×105 A/cm2 at 5 T as compared to a typical Jc of 2.4×103 A/cm2 at 5 T for a 300- nm -thick YBCO film. The thick YBCO +BSO...for a 300 nm thick YBCO film. The thick YBCO +BSO films maintained high Tc 88 K and had a high density 2.51011 /cm2 of continuous BSO nanocolumns...nanocolumns to maintain a high Jc in high magnetic fields without a reduction in Tc. Recently 300 nm thick YBCO +BSO nanocomposite films were processed using

  1. GtfA and GtfB Are Both Required for Protein O-Glycosylation in Lactobacillus plantarum

    PubMed Central

    Lee, I-Chiao; van Swam, Iris I.; Tomita, Satoru; Morsomme, Pierre; Rolain, Thomas; Hols, Pascal; Bron, Peter A.

    2014-01-01

    Acm2, the major autolysin of Lactobacillus plantarum WCFS1, was recently found to be O-glycosylated with N-acetylhexosamine, likely N-acetylglucosamine (GlcNAc). In this study, we set out to identify the glycosylation machinery by employing a comparative genomics approach to identify Gtf1 homologues, which are involved in fimbria-associated protein 1 (Fap1) glycosylation in Streptococcus parasanguinis. This in silico approach resulted in the identification of 6 candidate L. plantarum WCFS1 genes with significant homology to Gtf1, namely, tagE1 to tagE6. These candidate genes were targeted by systematic gene deletion, followed by assessment of the consequences on glycosylation of Acm2. We observed a changed mobility of Acm2 on SDS-PAGE in the tagE5E6 deletion strain, while deletion of other tagE genes resulted in Acm2 mobility comparable to that of the wild type. Subsequent mass spectrometry analysis of excised and in-gel-digested Acm2 confirmed the loss of glycosylation on Acm2 in the tagE5E6 deletion mutant, whereas a lectin blot using GlcNAc-specific succinylated wheat germ agglutinin (sWGA) revealed that besides Acm2, tagE5E6 deletion also abolished all but one other sWGA-reactive, protease-sensitive signal. Only complementation of both tagE5 and tagE6 restored those sWGA lectin signals, establishing that TagE5 and TagE6 are both required for the glycosylation of Acm2 as well as the vast majority of other sWGA-reactive proteins. Finally, sWGA lectin blotting experiments using a panel of 8 other L. plantarum strains revealed that protein glycosylation is a common feature in L. plantarum strains. With the establishment of these enzymes as protein glycosyltransferases, we propose to rename TagE5 and TagE6 as GtfA and GtfB, respectively. PMID:24532775

  2. Programming Contest Strategy

    ERIC Educational Resources Information Center

    Trotman, Andrew; Handley, Chris

    2008-01-01

    Each year the ACM hosts a truly international programming contest--the International Collegiate Programming Contest (ICPC). Dating back to a contest held by Texas A&M University in 1970, this annual event, along with the associated regional contests, has grown to 5606 teams from 1733 universities in 84 countries (in the year 2006). Despite the…

  3. Poll-before-Data Multiple Access

    DTIC Science & Technology

    1999-01-01

    MACA [6], MACAW [1], IEEE 802.11 [5], and FAMA [2], [4] are just a few examples. All of these MAC protocols, and most protocols based on collision...Shenker and L. Zhang, “ MACAW : A Media Access Protocol for Wireless LAN’s” Proc. ACM SIGCOMM 94, London, UK, Aug. 31 - Sep. 2, 1994. [2] C. L. Fullmer and

  4. Hop-Reservation Multiple Access (HRMA) for Ad-Hoc Networks

    DTIC Science & Technology

    1999-01-01

    5] and MACAW [6]. III. CORRECTNESS OF HRMA The following theorem proves that HRMA eliminates hidden- terminal interference problems. To prove this...Bharghavan, A. Demers, S. Shenker, and L. Zhang, “ MACAW : A Me- dia Access Protocol for Wireless LAN’s,” in Proc. ACM SIGCOMM ’94, pp. 212–25, London

  5. Enhanced performance and capacitance behavior of anode by rolling Fe3O4 into activated carbon in microbial fuel cells.

    PubMed

    Peng, Xinhong; Yu, Hongbing; Wang, Xin; Zhou, Qixing; Zhang, Shijia; Geng, Lijuan; Sun, Jingwen; Cai, Zhang

    2012-10-01

    Fe(3)O(4) was added into the anode to improve the performance of microbial fuel cells (MFCs). Stainless steel mesh (SSM), activated carbon (AC) with SSM (AcM) and Fe(3)O(4) added AcM (AcFeM) anodes had been made and investigated by electrochemical measurements. The maximum power density of AcFeM anode (809 ± 5 mW/m(2)) is 22% higher than that of AcM (664 ± 17 mW/m(2)), and 56 times higher than that of SSM anode (14 ± 0.3 mW/m(2)). Tafel tests indicate that the anode modified by Fe(3)O(4) is kinetically more advantageous. It is demonstrated for the first time that the capacitance of anode increased after the addition of Fe(3)O(4). With 10 min of interruption, AcFeM exhibites a 41% higher cumulative charge of 3566 ± 32 C/m(2) and a 32% higher net capacitance charge of 389 ± 18 C/m(2) than those of the AcM control (2529 ± 22 and 294 ± 30 C/m(2)), indicating that the improvement of anode performance can be also attributed to the enhancement of capacitance. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. 75 FR 52551 - Notice of Receipt of Complaint; Solicitation of Comments Relating to the Public Interest

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ... Guangdong, China; Seine Image International Co. Ltd. of New Territories, Hong Kong; Ninestar Technology Company, Ltd. of Piscataway, NJ; Ziprint Image Corporation of Walnut, CA; Nano Pacific Corporation of... Tech of South El Monte, CA; ACM Technologies, Inc. of Corona, CA; Virtual Imaging Products Inc....

  7. Enabling a Collaborative Problem-Solving Framework Through User Intent Modeling of the Analytic Process

    DTIC Science & Technology

    2009-08-01

    Nguyen, Eugene Santos Jr., Russell Jacob, and Nathan Smith. In Proceedings of 2008 IEEE/WIC/ACM International Conference on Web Intelligence. Sydney...of Social Cognition. • McDoland, D. W., and Ackerman , M. S. 2000. Expertise Recommender: A plexible recom- mendation system and architecture. In

  8. Multi-modal Social Networks: A MRF Learning Approach

    DTIC Science & Technology

    2016-06-20

    number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. University of Texas at Austin 101 East 27th Street Suite 5.300 Austin, TX 78712 -1532...14, Toronto, ON, Canada. : , . Topic modeling from network spread, The 2014 ACM international conference. 16-JUN-14, Austin, Texas , USA

  9. Spectral Analysis of Acceleration Data for Detection of Generalized Tonic-Clonic Seizures

    PubMed Central

    Joo, Hyo Sung; Han, Su-Hyun; Lee, Jongshill; Jang, Dong Pyo; Kang, Joong Koo; Woo, Jihwan

    2017-01-01

    Generalized tonic-clonic seizures (GTCSs) can be underestimated and can also increase mortality rates. The monitoring devices used to detect GTCS events in daily life are very helpful for early intervention and precise estimation of seizure events. Several studies have introduced methods for GTCS detection using an accelerometer (ACM), electromyography, or electroencephalography. However, these studies need to be improved with respect to accuracy and user convenience. This study proposes the use of an ACM banded to the wrist and spectral analysis of ACM data to detect GTCS in daily life. The spectral weight function dependent on GTCS was used to compute a GTCS-correlated score that can effectively discriminate between GTCS and normal movement. Compared to the performance of the previous temporal method, which used a standard deviation method, the spectral analysis method resulted in better sensitivity and fewer false positive alerts. Finally, the spectral analysis method can be implemented in a GTCS monitoring device using an ACM and can provide early alerts to caregivers to prevent risks associated with GTCS. PMID:28264522

  10. Integrating Programming Language and Operating System Information Security Mechanisms

    DTIC Science & Technology

    2016-08-31

    architecture to reason about information security. ACM...least 6 by PI Chong) on Shill and related research, including at Cornell University, NII Shonan ( Japan ), and Brown University. o Postdoctoral Fellow...of application architecture to enforce high-level application-specific information security guarantees (Chong and van der Meyden, 2015), the use

  11. 76 FR 13193 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ...: The invention offered for further commercial development relates to the coupling of virtual reality... virtual reality environments is sought for a CRADA collaboration. Inventors: Hyung S. Park (NIH/CC) and... control interface for treadmill locomotion in virtual environments. ACM Trans Appl Percept. 2007 Jan;4(1...

  12. On the Knowledge Underlying Multimedia Presentations

    DTIC Science & Technology

    1992-06-01

    1983. Semiology of Graphics, (trans. by J. Berg). Madison: University of * Wisconsin Press. 23 0 [Burger & Marshall 91] Burger, J. and Marshall, R...Architecture for Knowledge-Based Graphical Interfaces. ACM/SIGCHI Workshop on Architectures for Intelligent Interfaces: Elements and Proto- types, Monterey

  13. A Learning Research Informed Design and Evaluation of a Web-Enhanced Object Oriented Programming Seminar

    ERIC Educational Resources Information Center

    Georgantaki, Stavroula C.; Retalis, Symeon D.

    2007-01-01

    "Object-Oriented Programming" subject is included in the ACM Curriculum Guidelines for Undergraduate and Graduate Degree Programs in Computer Science as well as in Curriculum for K-12 Computer Science. In a few research studies learning problems and difficulties have been recorded, and therefore, specific pedagogical guidelines and…

  14. Administration of the Glial Condition Medium in the Nucleus Accumbens Prolong Maintenance and Intensify Reinstatement of Morphine-Seeking Behavior.

    PubMed

    Arezoomandan, Reza; Khodagholi, Fariba; Haghparast, Abbas

    2016-04-01

    Accumulating evidence suggested that glial cells are involved in synaptic plasticity and behavioral changes induced by drugs abuse. The role of these cells in maintenance and reinstatement of morphine (MRP) conditioned place preference (CPP) remains poorly characterized. The aim of present study was to investigate the direct role of glial cells in nucleus accumbens (NAc) in the maintenance and reinstatement of MRP-seeking behavior. CPP induced with injection of MRP (5 mg/kg, s.c. for 3 days), lasted for 7 days after cessation of MRP treatment and priming dose of MRP (1 mg/kg, s.c.) reinstated the extinguished MRP-induced CPP. The astrocyte-conditioned medium (ACM) and neuroglia conditioned medium (NCM) exposed to MRP (10 and 100 µM) have been microinjected into the NAc. Intra-NAc administration of ACM during extinction period failed to change the maintenance of MRP-CPP, but MRP 100-treated ACM could slightly increase the magnitude of reinstatement. In contrast to ACM, intra-NAc administration of MRP 100-treated NCM caused slower extinction by 3 days and significantly increased the magnitude of reinstatement. Our findings suggest the involvement of glial cells activation in the maintenance and reinstatement of MRP-seeking behaviors, and provides new evidence that these cells might be a potential target for the treatment of MRP addiction.

  15. Texture improvement of sputtered YBa 2Cu 3O 7- x films on MgO (100) with a SrTiO 3 buffer layer

    NASA Astrophysics Data System (ADS)

    Lucía, M. L.; Santamaría, J.; Iborra, E.; Hernández-Rojas, J. L.; Sánchez-Quesada, F.

    1993-12-01

    SrTiO 3 buffer layers have been grown on MgO (100) substrates to provide a better match to RF sputtered YBa 2Cu 3O 7- x films. This heterostructure allows a highly textured growth to be achieved over thickness as high as 1 μm. The granularity of films grown without buffer layer on MgO (100) and YSZ (100) has been shown to be thickness dependent affecting the critical current density: Jc at 77 K is typically 3 × 10 5 A/cm 2 in 1000 Å thin films while it reduces to 10 3 A/cm 2 in μm films. A of how the improvement of lattice matching makes the critical current density increase from 10 3 A/cm 2 for 1 μm films grown on YSZ to 4 × 10 5 A/cm 2 for films grown with a SrTiO 3 buffer layer.

  16. Positive role of peptidoglycan breaks in lactococcal biofilm formation.

    PubMed

    Mercier, Carine; Durrieu, Christele; Briandet, Romain; Domakova, Elena; Tremblay, Josselyne; Buist, Girbe; Kulakauskas, Saulius

    2002-10-01

    Bacterial attachment to solid matrices depends on adhesive molecules present on the cell surface. Here we establish a positive correlation between peptidoglycan (PG) breaks, rather than particular molecules, and biofilm-forming capacity in the Gram-positive bacterium Lactococcus lactis. The L. lactis acmA strain, which is defective in PG hydrolase, adhered less efficiently than the wild-type (wt) strain to different solid surfaces and was unable to form biofilms. These phenotypes were abolished by addition of lysozyme, a PG hydrolytic enzyme. Thus, the presence of PG breaks introduced by PG hydrolase, and not the AcmA protein itself, appears to be responsible for biofilm formation. Two different genetic screens confirmed the importance of PG breaks in L. lactis biofilm formation. Using the chain-forming ability of the acmA strain as a phenotypic indicator of PG integrity, we selected for insertional mutants generating short chains. Five independent mutants were all mapped to ponA, which encodes the PG synthesis enzyme PBP1A. Double acmA ponA mutants displayed increased adhesion and biofilm-forming capacity. Direct selection for strains with increased biofilm-forming capacity resulted in the isolation of another five mutations in ponA. Based on these results, we conclude that PG breaks are important for both adhesion and biofilm formation in L. lactis.

  17. Interactive effects of trait and state affect on top-down control of attention.

    PubMed

    Hur, Juyoen; Miller, Gregory A; McDavitt, Jenika R B; Spielberg, Jeffrey M; Crocker, Laura D; Infantolino, Zachary P; Towers, David N; Warren, Stacie L; Heller, Wendy

    2015-08-01

    Few studies have investigated how attentional control is affected by transient affective states while taking individual differences in affective traits into consideration. In this study, participants completed a color-word Stroop task immediately after undergoing a positive, neutral or negative affective context manipulation (ACM). Behavioral performance was unaffected by any ACM considered in isolation. For individuals high in trait negative affect (NA), performance was impaired by the negative but not the positive or neutral ACM. Neuroimaging results indicate that activity in primarily top-down control regions of the brain (inferior frontal gyrus and dorsal anterior cingulate cortex) was suppressed in the presence of emotional arousal (both negative and positive ACMs). This effect appears to have been exacerbated or offset by co-occurring activity in other top-down control regions (parietal) and emotion processing regions (orbitofrontal cortex, amygdala and nucleus accumbens) as a function of the valence of state affect (positive or negative) and trait affect (trait NA or trait PA). Neuroimaging results are consistent with behavioral findings. In combination, they indicate both additive and interactive influences of trait and state affect on top-down control of attention. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  18. Radioprotective Effect of Achillea millefolium L Against Genotoxicity Induced by Ionizing Radiation in Human Normal Lymphocytes

    PubMed Central

    Shahani, Somayeh; Rostamnezhad, Mostafa; Ghaffari-rad, Vahid; Ghasemi, Arash; Allahverdi Pourfallah, Tayyeb

    2015-01-01

    The radioprotective effect of Achillea millefolium L (ACM) extract was investigated against genotoxicity induced by ionizing radiation (IR) in human lymphocytes. Peripheral blood samples were collected from human volunteers and incubated with the methanolic extract of ACM at different concentrations (10, 50, 100, and 200 μg/mL) for 2 hours. At each dose point, the whole blood was exposed in vitro to 2.5 Gy of X-ray and then the lymphocytes were cultured with mitogenic stimulation to determine the micronuclei in cytokinesis-blocked binucleated cell. Antioxidant capacity of the extract was determined using free radical-scavenging method. The treatment of lymphocytes with the extract showed a significant decrease in the incidence of micronuclei binucleated cells, as compared with similarly irradiated lymphocytes without any extract treatment. The maximum protection and decrease in frequency of micronuclei were observed at 200 μg/mL of ACM extract which completely protected genotoxicity induced by IR in human lymphocytes. Achillea millefolium extract exhibited concentration-dependent radical-scavenging activity on 1,1-diphenyl-2-picryl hydrazyl free radicals. These data suggest that the methanolic extract of ACM may play an important role in the protection of normal tissues against genetic damage induced by IR. PMID:26675116

  19. Analysis of Navy Joint Contingency Contracting

    DTIC Science & Technology

    2011-12-01

    Scheduled Airlines Ticket Office SC Supply Corps SCM Supply Chain Management SEABEE Construction Battalion SES Senior Executive Service SOCOM U.S...are not disadvantaged by joint service. 15 Ronald H. Cole, ―Grenada, Panama, and Haiti: Joint...Management ( SCM ), or Operations Research – Analysis and Assessment (OR). Of the four degrees, FM and ACM are considered part of the professional

  20. Rewiring global regulator cAMP receptor protein (CRP) to improve E. coli tolerance towards low pH.

    PubMed

    Basak, Souvik; Geng, Hefang; Jiang, Rongrong

    2014-03-10

    Bioprocesses such as production of organic acids or acid hydrolysis of bioresources during biofuel production often suffer limitations due to microbial sensitivity under acidic conditions. Approaches for improving the acid tolerance of these microbes have mainly focused on using metabolic engineering tools. Here, we tried to improve strain acidic tolerance from its transcription level, i.e. we adopted error-prone PCR method to engineer global regulator cAMP receptor protein (CRP) of Escherichia coli to improve its performance at low pH. The best mutant AcM1 was identified from random mutagenesis libraries based on its growth performance. AcM1 almost doubled (0.113h(-1)) the growth rate of the control (0.062h(-1)) at pH 4.24. It also demonstrated better thermotolerance than the control at 48°C, whose growth was completely inhibited at this temperature. Quantitative real time reverse transcription PCR results revealed a stress response overlap among low pH stress-, oxidative stress- and osmotic stress-related genes. The chief enzyme responsible for cell acid tolerance, glutamate decarboxylase, demonstrated over twofold activity in AcM1 compared to the control. Differential binding properties of AcM1 mutant CRP with Class-I, II, and III CRP-dependent promoters suggested that modifications to native CRP may lead to transcription profile changes. Hence, we believe that transcriptional engineering of global regulator CRP can provide a new strain engineering alternative for E. coli.

  1. Environmental Compliance Assessment and Management Program (ECAMP)

    DTIC Science & Technology

    1994-06-01

    2-Propenenitrile ................................................. 107-13-1 U009 Aflatoxins ...under direction of USDA inspector to an approved facility for incineration, sterilization, or grinding into an approved sewage system - garbage is...subjected to grinding , casting, cutting. or abrading; and Category II nonfriable ACM that has a high probability of becoming crumbled, crushed, or

  2. 32 CFR 861.4 - DOD air transportation quality and safety requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... large jet aircraft. Example 2: Acme Air has been a DOD-approved cargo carrier for several years... FORCE AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM... business for the DOD, even when the aircraft involved is used exclusively for DOD missions. The...

  3. 32 CFR 861.4 - DOD air transportation quality and safety requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... large jet aircraft. Example 2: Acme Air has been a DOD-approved cargo carrier for several years... FORCE AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM... business for the DOD, even when the aircraft involved is used exclusively for DOD missions. The...

  4. 32 CFR 861.4 - DOD air transportation quality and safety requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... large jet aircraft. Example 2: Acme Air has been a DOD-approved cargo carrier for several years... FORCE AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM... business for the DOD, even when the aircraft involved is used exclusively for DOD missions. The...

  5. 32 CFR 861.4 - DOD air transportation quality and safety requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... large jet aircraft. Example 2: Acme Air has been a DOD-approved cargo carrier for several years... FORCE AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM... business for the DOD, even when the aircraft involved is used exclusively for DOD missions. The...

  6. 32 CFR 861.4 - DOD air transportation quality and safety requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... large jet aircraft. Example 2: Acme Air has been a DOD-approved cargo carrier for several years... FORCE AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM... business for the DOD, even when the aircraft involved is used exclusively for DOD missions. The...

  7. Precipitation collector bias and its effects on temporal trends and spatial variability in National Atmospheric Deposition Program/National Trends Network data

    USGS Publications Warehouse

    Wetherbee, Gregory A.

    2017-01-01

    Precipitation samples have been collected by the National Atmospheric Deposition Program's (NADP) National Trends Network (NTN) using the Aerochem Metrics Model 301 (ACM) collector since 1978. Approximately one-third of the NTN ACM collectors have been replaced with N-CON Systems, Inc. Model ADS 00-120 (NCON) collectors. Concurrent data were collected over 6 years at 12 NTN sites using colocated ACM and NCON collectors in various precipitation regimes. Linear regression models of the colocated data were used to adjust for relative bias between the collectors. Replacement of ACM collectors with NCON collectors resulted in shifts in 10-year seasonal precipitation-weighted mean concentration (PWMC) trend slopes for: cations (−0.001 to −0.007 mgL−1yr−1), anions (−0.009 to −0.028 mgL−1yr−1), and hydrogen ion (+0.689 meqL-1yr−1). Larger shifts in NO3− and SO4−2 seasonal PWMC trend slopes were observed in the Midwest and Northeast US, where concentrations are generally higher than in other regions. Geospatial analysis of interpolated concentration rasters indicated regions of accentuated variability introduced by incorporation of NCON collectors into the NTN.

  8. Learning and Repair Techniques for Self-Healing Systems

    DTIC Science & Technology

    2006-05-01

    2] S. Ceri , P. Fraternali, S. Paraboschi, and L. Tanca. Automatic generation of production rules for integrity maintenance. ACM Transactions on...Database Systems, 19(3), September 1994. [3] S. Ceri and J. Widom. Deriving production rules for constraint maintenance. In Very Large Data Bases

  9. The Prospects for Increasing the Reuse of Digital Training Content

    DTIC Science & Technology

    2009-01-01

    Advanced Research Project Agency’s Megaprogram- ming effort (in the early 1990s) was a resounding failure (Wiederhold, Wegner, and Ceri , 1992; Boehm and...Wegner, and S. Ceri (1992). “Towards Megaprogramming.” Communications of the ACM, 33(11), November 1992, 89–99. Yourdon, E., and L. Constantine

  10. 76 FR 50148 - Notice of Intent to Negotiate Proposed Rule on Energy Efficiency Standards for Distribution...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... Council Robin Roy AK Steel Corporation Jerry Schoen California Energy Commission (as resource party) Acme... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY 10 CFR Part 431 RIN 1904-AC62 Notice of Intent to Negotiate Proposed Rule on Energy Efficiency Standards for...

  11. Multigrid Equation Solvers for Large Scale Nonlinear Finite Element Simulations

    DTIC Science & Technology

    1999-01-01

    algorithm in three dimensions. In Proc. Second Ann. ACM Symp. Comp. Geom., 1986. [39] J. Fish, V. Belsky , and S. Gomma. Unstructured multigrid method...for shells. International Journal for Numerical Methods in Engineering, 39:1181{1197, 1996. [40] J. Fish, M. Pandheeradi, and V. Belsky . An ecient

  12. Exploring Group Communication and Productivity Improvement: Using an Experiential Process.

    ERIC Educational Resources Information Center

    Mandeville, Mary Y.; Mandeville, David E.

    Engineering students at Oklahoma State University used an experiential process (the ACME Basket Exercise) to develop an understanding of how quality and productivity can be improved. The exercise simulates a traditional production organization in the classroom and mirrors the efforts, the successes, and the frustrations of individuals and work…

  13. Lean and Efficient Software: Whole Program Optimization of Executables

    DTIC Science & Technology

    2016-12-31

    Payer, M., Wagner , D., and Gross, T. R., Control-flow bending: On the effectiveness of control-flow integrity. In 24th USENIX Security Symposium...USENIX Security 15). pp. 161-176. 9. Karl Chen and David Wagner , Large-scale analysis of format string vulnerabilities in Debian Linux. In ACM

  14. Detection Of Malware Collusion With Static Dependence Analysis On Inter APP Communication

    DTIC Science & Technology

    2016-12-08

    Adrienne Porter Felt, Kate Greenwood, and David Wagner . “Analyzing inter-application communication in Android.”, 9th international conference on...Conference on Computer and Communications Security, pp. 735-746. ACM, 2016. [17]. Kantola, David, Erika Chin, Warren He, and David Wagner . “Reducing

  15. Interactive Synthesis of Code Level Security Rules

    DTIC Science & Technology

    2017-04-01

    testing and analysis, pages 163–173. ACM, 2007. [18] H. Chen and D. Wagner . MOPS: an infrastructure for examining security properties of soft- ware. In...Talwar, J. S. Foster, and D. Wagner . Detecting format string vulnerabilities with type qualifiers. In USENIX Security Symposium, pages 201–220, 2001

  16. Measuring Computer Usage by Air Force Contracting Personnel as it Relates to Computer Training

    DTIC Science & Technology

    1996-09-01

    Computers in Human Behavior 12.1...34 Computers in Human Behavior 3 (1987): 49-59. Howard, G. S. and R. D. Smith. "Computer Anxiety in Management: Myth or Reality." Communications of the ACM 29...34 Computers in Human Behavior 9 (1993): 27-50. 34 Szajna, Bernadette. "An Investigation of the Predictive Validity of Computer Anxiety and

  17. The Investigation of Pointing Behaviors in Web Browsing

    DTIC Science & Technology

    2016-09-26

    Optimization of Socially Sourced Images using Psychovisual Enhancements, 7th ACM Multimedia Systems Conference (MMSys 2016). 12-MAY-16, Klagenfurt...understand the variance. Technology Transfer From our study, we have learned that the way one can apply Fitts’ law to web browsing is different from

  18. Coupling of Waves, Turbulence and Thermodynamics Across the Marginal Ice Zone

    DTIC Science & Technology

    2015-09-30

    acoustic travel-time current meter ACM 3D current meter, with 0.5mm s-1 rms noise level), an inductive conductivity cell (± 0.002 mS cm-1), a platinum...conditions. Local morphology of the ice base surrounding the entrainment mast were made with a high resolution acoustic fan beam scanned profiler and

  19. Are Academic Programs Adequate for the Software Profession?

    ERIC Educational Resources Information Center

    Koster, Alexis

    2010-01-01

    According to the Bureau of Labor Statistics, close to 1.8 million people, or 77% of all computer professionals, were working in the design, development, deployment, maintenance, and management of software in 2006. The ACM [Association for Computing Machinery] model curriculum for the BS in computer science proposes that about 42% of the core body…

  20. Grounding the Scholarship of Teaching and Learning in Practice

    ERIC Educational Resources Information Center

    Tenenberg, Josh; McCartney, Robert

    2008-01-01

    We invite submissions to ACM/JERIC from teaching practitioners who are our readers. Grounding these submissions in the lived practice of teaching; using data that is already collected to assess student learning; and reporting the data collection, analysis, and context of use accurately and honestly are key aspects for taking a scholarly approach…

  1. Beyond the Model: Building an Effective and Dynamic IT Curriculum

    ERIC Educational Resources Information Center

    Brewer, Jeffrey; Harriger, Alka; Mendonca, John

    2006-01-01

    A model curriculum, such as that developed by the ACM/SIGITE Curriculum Committee (2005), has two important functions. First, it provides a base structure for newly developing programs that can use it as a platform for articulating a curriculum. Second, it offers an existing curriculum framework that can be used for validation by existing…

  2. Programming Contest Strategy

    ERIC Educational Resources Information Center

    Trotman, Andrew; Handley, Chris

    2008-01-01

    Each year the ACM hosts a truly international programming contest--the International Collegiate Programming Contest (ICPC). Dating back to a contest held by Texas A&M University in 1970, this annual event, along with the associated regional contests, has grown to 5606 teams from 1733 universities in 84 countries (in the year 2006). Despite the…

  3. Organizing International Programs: The Experience of Two Consortia.

    ERIC Educational Resources Information Center

    Neff, Charles B.; Fuller, Jon W.

    1983-01-01

    Two academic consortia have achieved success in sponsoring international programs, which any one of their member institutions would be unlikely to undertake alone. The Associated Colleges of the Midwest (ACM) and the Great Lakes Colleges Association (GLCA) programs are described. (MLW)

  4. A REPORT ON THE SECOND YEAR, 1964-65, OF THE URBAN SEMESTER, A PROGRAM IN TEACHER EDUCATION OF THE ASSOCIATED COLLEGES OF THE MIDWEST.

    ERIC Educational Resources Information Center

    Associated Colleges of the Midwest, Chicago, IL.

    TO PREPARE STUDENTS FOR TEACHING IN URBAN SCHOOLS, 27 SELECTED SENIOR STUDENTS FROM ASSOCIATED COLLEGES OF THE MIDWEST (ACM) SPENT 16 WEEKS (BEGINNING IN SEPTEMBER 1964) OBSERVING, TEACHING, AND STUDYING IN CHICAGO. THE FIRST 8 WEEKS WERE SPENT IN AN AVERAGE SOCIOECONOMIC-LEVEL SCHOOL AND THE FINAL 8 WEEKS IN A DISADVANTAGED SCHOOL. THE STUDENTS…

  5. An Automated Pronunciation - Hearing Instruction Aid: Refinements and Applications

    ERIC Educational Resources Information Center

    Smith, Donald L.

    1975-01-01

    Describes an automated device for teaching and testing the pronunciation of a language to a non-native speaker without the assistance of a trained teacher. This device was developed at the Research Institute of Logopedics and Phoniatrics at the University of Tokyo. Available from SIGLASH, c/o ACM, P.O. Box 12105, Church St. Station, New York, NY…

  6. Multi-Sensory Informatics Education

    ERIC Educational Resources Information Center

    Katai, Zoltan; Toth, Laszlo; Adorjani, Alpar Karoly

    2014-01-01

    A recent report by the joint Informatics Europe & ACM Europe Working Group on Informatics Education emphasizes that: (1) computational thinking is an important ability that all people should possess; (2) informatics-based concepts, abilities and skills are teachable, and must be included in the primary and particularly in the secondary school…

  7. Colonization of Clonostachys rosea on soybean root inoculated with Fusarium graminearum

    USDA-ARS?s Scientific Manuscript database

    Soybean root rot, caused by Fusarium graminearum, is a devastating disease. Clonostachys rosea has been reported to have protection against plant pathogens in different crops. The objectives of this study were to determine if a strain of C. rosea (ACM941) can colonize soybean root that were inocula...

  8. Self-Perceived and Observable Self-Direction in an Online Asynchronous Programming Course Using Peer Learning Forums

    ERIC Educational Resources Information Center

    Gaspar, Alessio; Langevin, Sarah; Boyer, Naomi; Armitage, William

    2009-01-01

    This study broadens the objectives of previous work (Boyer, N., Langevin, S., Gaspar, A. (2008). "Self direction and constructivism in programming education." "Proceedings of the ACM Special Interest Group in IT Education Conference," 16-18 October 2008, Cincinnati, OH) in which we used a survey-based instrument, the Personal…

  9. The Fate of the Communist Ideal of Education.

    ERIC Educational Resources Information Center

    Gessen, S. I.

    1995-01-01

    Maintains that during the first 15 years of Soviet rule, the Communist Party's school policy went through at least 5 transformations. Describes these changes in light of Stalin's New Economic Policy. Speculates that the Russian school system will return to its slow progress toward "Americanization." (ACM)

  10. Extracurricular Activities and High School Dropouts.

    ERIC Educational Resources Information Center

    McNeal, Ralph B., Jr.

    1995-01-01

    Reports on a study of 14,249 students to determine whether participation in specific extracurricular activities (athletics and fine arts) significantly reduces a student's likelihood of dropping out. Finds that, when all activities are examined, only athletic participation remains significantly related to dropping out. (ACM)

  11. The role of symmetry in nuclear physics

    NASA Astrophysics Data System (ADS)

    Iachello, Francesco

    2015-02-01

    The role of discrete symmetries in nuclear physics is briefly reviewed within the context of the algebraic cluster model (ACM). The symmetries D3 (triangle) for 3α and Td (tetrahedron) for 4α are discussed and evidence shown for their occurrence in 12C (D3) and 16O (Td).

  12. Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death

    PubMed Central

    Omatsu-Kanbe, Mariko; Nozuchi, Nozomi; Nishino, Yuka; Mukaisho, Ken-ichi; Sugihara, Hiroyuki; Matsuura, Hiroshi

    2017-01-01

    Atypically-shaped cardiomyocytes (ACMs) are beating heart cells identified in the cultures of cardiomyocyte-removed fractions obtained from adult mouse hearts. Since ACMs spontaneously develop into beating cells in the absence of hormones or chemicals, these cells are likely to be a type of cardiac progenitors rather than stem cells. “Native ACMs” are found as small interstitial cells among ventricular myocytes that co-express cellular prion protein (PrP) and cardiac troponin T (cTnT) in mouse and human heart tissues. However, the endogenous behavior of human ACMs is unclear. In the present study, we demonstrate that PrP+ cTnT+ cells are present in the human heart tissue with myocardial infarction (MI). These cells were mainly found in the border of necrotic cardiomyocytes caused by infarcts and also in the hibernating myocardium subjected to the chronic ischemia. The ratio of PrP+ cTnT+ cells to the total cells observed in the normal heart tissue section of mouse and human was estimated to range from 0.3–0.8%. Notably, living human PrP+ cTnT+ cells were identified in the cultures obtained at pathological autopsy despite exposure to lethal ischemic conditions for hours after death. These findings suggest that ACMs could survive in the ischemic human heart and develop into a sub-population of cardiac myocytes. PMID:28120944

  13. Reshaping Religious and Theological Education in the 90's: Toward a Critical Pluralism.

    ERIC Educational Resources Information Center

    Johnson, Susanne

    1993-01-01

    Contends that many people feel that academic excellence in higher education is being threatened by multicultural education. Provides a summary of the issues and argues that religious educators should be guided by the concept of "hospitality" regarding minority and other underrepresented groups in education. (ACM)

  14. Hard Biscuits: Motivation to Learn in Secondary School Social Studies.

    ERIC Educational Resources Information Center

    Allen, Rodney F.

    1995-01-01

    Maintains that much of the high school curriculum, particularly in social studies, contains innumerable facts that have no use except to pass school tests. Reviews research on effective instruction as applied to social studies. Includes 17 characteristics of highly engaging social studies teaching and learning. (ACM)

  15. Six-Hat Social Studies. Classroom Teacher's Idea Notebook.

    ERIC Educational Resources Information Center

    Pahl, Ron H.

    1995-01-01

    Contends that research confirms that too many names, dates, and facts can make social studies boring and irrelevant. Proposes a four-step approach to help students examine issues rather than merely learn facts. Describes a lesson on ethnic discrimination and presents a composite teacher-student dialog. (ACM)

  16. Teaching Perspectives among Introductory Computer Programming Faculty in Higher Education

    ERIC Educational Resources Information Center

    Mainier, Michael J.

    2011-01-01

    This study identified the teaching beliefs, intentions, and actions of 80 introductory computer programming (CS1) faculty members from institutions of higher education in the United States using the Teacher Perspectives Inventory. Instruction method used inside the classroom, categorized by ACM CS1 curriculum guidelines, was also captured along…

  17. A Learning Research Informed Design and Evaluation of a Web-Enhanced Object Oriented Programming Seminar

    ERIC Educational Resources Information Center

    Georgantaki, Stavroula C.; Retalis, Symeon D.

    2007-01-01

    "Object-Oriented Programming" subject is included in the ACM Curriculum Guidelines for Undergraduate and Graduate Degree Programs in Computer Science as well as in Curriculum for K-12 Computer Science. In a few research studies learning problems and difficulties have been recorded, and therefore, specific pedagogical guidelines and…

  18. Made in Hawai'i: Critical Studies and the Academy for Creative Media

    ERIC Educational Resources Information Center

    Ng, Konrad

    2009-01-01

    In this article, the author offers a brief history of the Academy for Creative Media (ACM)--the University of Hawai'i's primary academic program for the production and study of film, animation, and computer game design--and its mission to fulfill the Hawai'i state government's agenda to diversify the economy with creative media and high…

  19. Speech and Theatre Programs in Two Midwest Consortia.

    ERIC Educational Resources Information Center

    Buzza, Bonnie Wilson

    The official college catalogues of the 25 institutions comprising the Associated Colleges of the Midwest (ACM) and the Great Lakes Colleges Association (GLCA) consortia were studied to provide descriptive information on the special needs and interests of smaller speech and theatre programs. Information on speech departments indicated three general…

  20. Evaluating the Equal-Interval Hypothesis with Test Score Scales

    ERIC Educational Resources Information Center

    Domingue, Benjamin Webre

    2012-01-01

    In psychometrics, it is difficult to verify that measurement instruments can be used to produce numeric values with the desirable property that differences between units are equal-interval because the attributes being measured are latent. The theory of additive conjoint measurement (e.g., Krantz, Luce, Suppes, & Tversky, 1971, ACM) guarantees…