cAMP-dependent and cholinergic regulation of the electrogenic intestinal/pancreatic Na+/HCO3- cotransporter pNBC1 in human embryonic kidney (HEK293) cells.

PubMed

Bachmann, Oliver; Franke, Kristin; Yu, Haoyang; Riederer, Brigitte; Li, Hong C; Soleimani, Manoocher; Manns, Michael P; Seidler, Ursula

2008-12-22

The renal (kNBC1) and intestinal (pNBC1) electrogenic Na+/HCO3- cotransporter variants differ in their primary structure, transport direction, and response to secretagogues. Previous studies have suggested that regulatory differences between the two subtypes can be partially explained by unique consensus phosphorylation sites included in the pNBC1, but not the kNBC1 sequence. After having shown activation of NBC by carbachol and forskolin in murine colon, we now investigated these pathways in HEK293 cells transiently expressing a GFP-tagged pNBC1 construct. Na+- and HCO3-dependent pHi recovery from an acid load (measured with BCECF) was enhanced by 5-fold in GFP-positive cells compared to the control cells in the presence of CO2/HCO3-. Forskolin (10(-5) M) had no effect in untransfected cells, but inhibited the pHi recovery in cells expressing pNBC1 by 62%. After preincubation with carbachol (10(-4) M), the pHi recovery was enhanced to the same degree both in transfected and untransfected cells, indicating activation of endogenous alkalizing ion transporters. Acid-activated Na+/HCO3- cotransport via pNBC1 expressed in renal cells is thus inhibited by cAMP and not affected by cholinergic stimulation, as opposed to the findings in native intestinal tissue. Regulation of pNBC1 by secretagogues appears to be not solely dependent on its primary structure, but also on properties of the cell type in which it is expressed.

Integrated responses of Na+/HCO3- cotransporters and V-type H+-ATPases in the fish gill and kidney during respiratory acidosis.

PubMed

Perry, S F; Furimsky, M; Bayaa, M; Georgalis, T; Shahsavarani, A; Nickerson, J G; Moon, T W

2003-12-30

Using degenerate primers, followed by 3' and 5' RACE and "long" PCR, a continuous 4050-bp cDNA was obtained and sequenced from rainbow trout (Oncorhynchus mykiss) gill. The cDNA included an open reading frame encoding a deduced protein of 1088 amino acids. A BLAST search of the GenBank protein database demonstrated that the trout gene shared high sequence similarity with several vertebrate Na(+)/HCO(3)(-) cotransporters (NBCs) and in particular, NBC1. Protein alignment revealed that the trout NBC is >80% identical to vertebrate NBC1s and phylogenetic analysis provided additional evidence that the trout NBC is indeed a homolog of NBC1. Using the same degenerate primers, a partial cDNA (404 bp) for NBC was obtained from eel (Anguilla rostrata) kidney. Analysis of the tissue distribution of trout NBC, as determined by Northern blot analysis and real-time PCR, indicated high transcript levels in several absorptive/secretory epithelia including gill, kidney and intestine and significant levels in liver. NBC mRNA was undetectable in eel gill by real-time PCR. In trout, the levels of gill NBC1 mRNA were increased markedly during respiratory acidosis induced by exposure to hypercarbia; this response was accompanied by a transient increase in branchial V-type H(+)-ATPase mRNA levels. Assuming that the branchial NBC1 is localised to basolateral membranes of gill cells and operates in the influx mode (HCO(3)(-) and Na(+) entry into the cell), it would appear that in trout, the expression of branchial NBC1 is transcriptionally regulated to match the requirements of gill pHi regulation rather than to match trans-epithelial HCO(3)(-) efflux requirements for systemic acid-base balance. By analogy with mammalian systems, NBC1 in the kidney probably plays a role in the tubular reabsorption of both Na(+) and HCO(3)(-). During periods of respiratory acidosis, levels of renal NBC1 mRNA increased (after a transient reduction) in both trout and eel, presumably to increase HCO(3)(-) reabsorption. This strategy, when coupled with increased urinary acidification associated with increased vacuolar H(+)-ATPase activity, ensures that HCO(3)(-) levels accumulate in the body fluids to restore pH.

Evidence of reduced bladder capacity during nighttime in children with monosymptomatic nocturnal enuresis.

PubMed

Borg, B; Kamperis, K; Olsen, L H; Rittig, S

2018-04-01

Bladder capacity in children with nocturnal enuresis is assessed by maximal voided volumes (MVV) obtained through daytime frequency volume (FV) charts. Although a degree of association has been demonstrated, daytime MVV does not consistently correspond with the nocturnal bladder capacity (NBC) in monosymptomatic nocturnal enuresis (MNE). It was hypothesized that isolated reduced NBC is a common phenomenon in children with nocturnal enuresis, despite normal daytime bladder function. The aim of this study was to evaluate NBC in children with MNE and normal daytime voided volumes. Specifically, it aimed to determine the prevalence and degree of reduced NBC when using nocturnal urine production (NUP) during wet nights as a surrogate estimate of NBC. Furthermore, it aimed to investigate the relationship between NBC and desmopressin response. Data from 103 children aged 5-15 years consecutively treated for MNE in a tertiary referral centre and with normal MVV on daytime FV charts were collected for this cohort study. Home recordings were completed for 2 weeks at baseline and during desmopressin dose titration. Estimated nocturnal bladder capacity (eNBC) was assessed separately each night as the total NUP causing a wet night. If NUP during a wet night was less than MVV, it was considered to be reduced eNBC during that particular night. Surprisingly, 82% (n = 84) of the children with MNE and normal daytime MVV experienced at least one wet night, with NUP below the daytime MVV indicative of a reduced eNBC. For 84 patients, mean percentage of wet nights with reduced eNBC (NUP below MVV) was 49% (SD ± 31). A total of 11% of children with frequently reduced eNBC (>40% of wet nights with reduced eNBC) responded to desmopressin (Summary Fig.). Of the children with frequently reduced NBC, 91% experienced wet nights, with NUP <65% of expected bladder capacity (EBC). A significant proportion of children with MNE and normal MVV during the daytime frequently experienced wet nights, with a NUP well below their MVV and even <65% of EBC. This indicated that bladder reservoir dysfunction during sleep is relatively common in MNE. This abnormality was not reflected on daytime recordings, and thus nighttime data with NUP must be collected. This phenomenon may explain treatment failure to desmopressin, despite adequate antidiuretic response. Copyright © 2017 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

Comparing metabolic effects of six different commercial trivalent chromium compounds.

PubMed

Preuss, Harry G; Echard, Bobby; Perricone, Nicholas V; Bagchi, Debasis; Yasmin, Taharat; Stohs, Sidney J

2008-11-01

Recent reports provide cogent evidence that the average individual becomes chromium deficient with age. Unfortunately, chromium deficiency is strongly associated with many aspects of the Metabolic Syndrome, including insulin resistance and type 2 diabetes. Since replacement of chromium, per os, often ameliorates many deleterious manifestations associated with insulin resistance and diabetes, it is not surprising that many different, commercial trivalent chromium compounds are available on the market. However, previous reports have shown that the form of trivalent chromium (negative charges) can influence effectiveness markedly. We compared various commercial forms of trivalent chromium commonly used alone or in formulations, to examine whether they are equally effective and non-toxic. In the first study, five different chromium products were examined - citrate, amino acid chelate (AAC), chelavite, polynicotinate (NBC), and nicotinate. In the second study, effects of NBC and picolinate were assessed. Results demonstrated that only chelavite and NBC improved insulin sensitivity, and only NBC decreased systolic blood pressure (SBP) significantly. In the second study, both picolinate and NBC significantly decreased SBP compared to control. NBC and picolinate decreased malonyldialdehyde concentrations (free radical formation) and DNA fragmentation in hepatic and renal tissues. No evidence of adverse effects was noted with any of the compounds tested. In conclusion, while all the trivalent chromium compounds tested seem safe, only three enhanced insulin sensitivity (NBC, chelavite, and picolinate) and only two decreased SBP significantly (NBC and picolinate). Furthermore, both NBC and picolinate were protective in lessening free radical formation and DNA damage in the liver and kidneys.

Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injury.

PubMed

Penumathsa, Suresh Varma; Thirunavukkarasu, Mahesh; Samuel, Samson Mathews; Zhan, Lijun; Maulik, Gautam; Bagchi, Manashi; Bagchi, Debasis; Maulik, Nilanjana

2009-01-01

Diabetes, one of the major risk factors of metabolic syndrome culminates in the development of Ischemic Heart Disease (IHD). Refined diets that lack micronutrients, mainly trivalent chromium (Cr(3+)) have been identified as the contributor in the rising incidence of diabetes. We investigated the effect of niacin-bound chromium (NBC) during ischemia/reperfusion (IR) injury in streptozotocin induced diabetic rats. Rats were randomized into: Control (Con); Diabetic (Dia) and Diabetic rats fed with NBC (Dia+NBC). After 30 days of treatment, the isolated hearts were subjected to 30 min of global ischemia followed by 2 h of reperfusion. NBC treatment demonstrated significant increase in left ventricular functions and significant reduction in infarct size and cardiomyocyte apoptosis in Dia+NBC compared with Dia. Increased Glut-4 translocation to the lipid raft fractions was also observed in Dia+NBC compared to Dia. Reduced Cav-1 and increased Cav-3 expression along with phosphorylation of Akt, eNOS and AMPK might have resulted in increased Glut-4 translocation in Dia+NBC. Our results indicate that the cardioprotective effect of NBC is mediated by increased activation of AMPK, Akt and eNOS resulting in increased translocation of Glut-4 to the caveolar raft fractions thereby alleviating the effects of IR injury in the diabetic myocardium.

Effectiveness of National Board Certified (NBC) Teachers in Terms of Classroom Environment, Attitudes and Achievement among Secondary Science Students

ERIC Educational Resources Information Center

Helding, Karen A.; Fraser, Barry J.

2013-01-01

No previous research has employed learning environments criteria in evaluating the effectiveness of the system of teacher certification sponsored by the National Board for Professional Teaching Standards. Because the litmus test of any professional development effort is the extent of the changes in teaching behaviours in participating teachers'…

Joshua Schaidle | NREL

Science.gov Websites

, NREL, NBC, 2015-present Staff Engineer, NREL, NBC, 2012-present Post-Doctoral Researcher, NREL, NBC Bio-Oil via Ex Situ Catalytic Fast Pyrolysis and Hydrotreating," Fuel (2017) "An Biorefining (2016) "Conceptual Process Design and Techno-Economic Assessment of Ex Situ Catalytic Fast

Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction

PubMed Central

Sasahira, Naoki; Hamada, Tsuyoshi; Togawa, Osamu; Yamamoto, Ryuichi; Iwai, Tomohisa; Tamada, Kiichi; Kawaguchi, Yoshiaki; Shimura, Kenji; Koike, Takero; Yoshida, Yu; Sugimori, Kazuya; Ryozawa, Shomei; Kakimoto, Toshiharu; Nishikawa, Ko; Kitamura, Katsuya; Imamura, Tsunao; Mizuide, Masafumi; Toda, Nobuo; Maetani, Iruru; Sakai, Yuji; Itoi, Takao; Nagahama, Masatsugu; Nakai, Yousuke; Isayama, Hiroyuki

2016-01-01

AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction. METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent (PS) or nasobiliary catheter (NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedure-related adverse events, stent/catheter dysfunction (occlusion or migration of PS/NBC, development of cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution (bilirubin level < 3.0 mg/dL) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis. RESULTS: In total, 419 patients were included in the study (PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients (46%), bile duct cancer in 172 (41%), gallbladder cancer in three (1%), and ampullary cancer in 50 (12%). The median serum total bilirubin was 7.8 mg/dL and 324 patients (77%) had ≥ 3.0 mg/dL. During the median time to surgery of 29 d [interquartile range (IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio (SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method (PS or NBC). CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. PMID:27076764

Why do we power our cars with gas? NBC Chicago

ScienceCinema

None

2018-02-06

Why can we only power our cars with gas? NBC-Chicago tackles this question with a trip to Argonne National Lab, where work on the Omnivorous Engine (runs on any blend of ethanol, butanol, and gasoline) and electric vehicles continues. A segment from NBC-Chicago's "Good Question" series.

Network Evening News Coverage of Environmental Risk.

ERIC Educational Resources Information Center

Greenberg, Michael R.; And Others

Focusing on ABC, NBC, and CBS's evening news broadcasts from January 1984 through February 1986, a study examined network news coverage of environmental risk--defined as manmade chemical, biological, and physical agents that create risk in the indoor, outdoor, and occupational environments. Using the Vanderbilt University "Television News…

Orthopedic board certification and physician performance: an analysis of medical malpractice, hospital disciplinary action, and state medical board disciplinary action rates.

PubMed

Kocher, Mininder S; Dichtel, Laura; Kasser, James R; Gebhardt, Mark C; Katz, Jeffery N

2008-02-01

Specialty board certification status has become the de facto standard of competency by which the profession and the public recognize physician specialists. However, the relationship between orthopedic board certification and physician performance has not been established. Rates of medical malpractice claims, hospital disciplinary actions, and state medical board disciplinary actions were compared between 1309 board-certified (BC) and 154 non-board-certified (NBC) orthopedic surgeons in 3 states. There was no significant difference between BC and NBC surgeons in medical malpractice claim proportions (BC, 19.1% NBC, 16.9% P = .586) or in hospital disciplinary action proportions (BC, 0.9% NBC, 0.8% P = 1.000). There was a significantly higher proportion of state medical board disciplinary action for NBC surgeons (BC, 7.6% NBC, 13.0% P = .028). An association between board certification status and physician performance is necessary to validate its status as the de facto standard of competency. In this study, BC surgeons had lower rates of state medical board disciplinary action.

What is the importance of climate model bias when projecting the impacts of climate change on land surface processes?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, M. L.; Rajagopalan, K.; Chung, S. H.

2014-05-16

Regional climate change impact (CCI) studies have widely involved downscaling and bias-correcting (BC) Global Climate Model (GCM)-projected climate for driving land surface models. However, BC may cause uncertainties in projecting hydrologic and biogeochemical responses to future climate due to the impaired spatiotemporal covariance of climate variables and a breakdown of physical conservation principles. Here we quantify the impact of BC on simulated climate-driven changes in water variables(evapotranspiration, ET; runoff; snow water equivalent, SWE; and water demand for irrigation), crop yield, biogenic volatile organic compounds (BVOC), nitric oxide (NO) emissions, and dissolved inorganic nitrogen (DIN) export over the Pacific Northwest (PNW)more » Region. We also quantify the impacts on net primary production (NPP) over a small watershed in the region (HJ Andrews). Simulation results from the coupled ECHAM5/MPI-OM model with A1B emission scenario were firstly dynamically downscaled to 12 km resolutions with WRF model. Then a quantile mapping based statistical downscaling model was used to downscale them into 1/16th degree resolution daily climate data over historical and future periods. Two series climate data were generated according to the option of bias-correction (i.e. with bias-correction (BC) and without bias-correction, NBC). Impact models were then applied to estimate hydrologic and biogeochemical responses to both BC and NBC meteorological datasets. These im20 pact models include a macro-scale hydrologic model (VIC), a coupled cropping system model (VIC-CropSyst), an ecohydrologic model (RHESSys), a biogenic emissions model (MEGAN), and a nutrient export model (Global-NEWS). Results demonstrate that the BC and NBC climate data provide consistent estimates of the climate-driven changes in water fluxes (ET, runoff, and water demand), VOCs (isoprene and monoterpenes) and NO emissions, mean crop yield, and river DIN export over the PNW domain. However, significant differences rise from projected SWE, crop yield from dry lands, and HJ Andrews’s ET between BC and NBC data. Even though BC post-processing has no significant impacts on most of the studied variables when taking PNW as a whole, their effects have large spatial variations and some local areas are substantially influenced. In addition, there are months during which BC and NBC post-processing produces significant differences in projected changes, such as summer runoff. Factor-controlled simulations indicate that BC post-processing of precipitation and temperature both substantially contribute to these differences at region scales. We conclude that there are trade-offs between using BC climate data for offline CCI studies vs. direct modeled climate data. These trade-offs should be considered when designing integrated modeling frameworks for specific applications; e.g., BC may be more important when considering impacts on reservoir operations in mountainous watersheds than when investigating impacts on biogenic emissions and air quality (where VOCs are a primary indicator).« less

Defense Technology Area Plan.

DTIC Science & Technology

1996-05-01

Nonpolluting fouling-resistant or fouling-release hull coatings, which exploit low- surface-energy and surface-oriented perfluorinated alkyl compounds ... compounds Novel radioprotective drugs Fieldable biodosimetry capability Modeling for casualties in NBC environments Combined injury treatment protocols...Viral Agents, including encephalomyelitis viruses, variola (smallpox), and filoviridae (e.g., Ebola virus). • Neuroactive Compounds , including

Ergonomic intervention for improving work postures during notebook computer operation.

PubMed

Jamjumrus, Nuchrawee; Nanthavanij, Suebsak

2008-06-01

This paper discusses the application of analytical algorithms to determine necessary adjustments for operating notebook computers (NBCs) and workstations so that NBC users can assume correct work postures during NBC operation. Twenty-two NBC users (eleven males and eleven females) were asked to operate their NBCs according to their normal work practice. Photographs of their work postures were taken and analyzed using the Rapid Upper Limb Assessment (RULA) technique. The algorithms were then employed to determine recommended adjustments for their NBCs and workstations. After implementing the necessary adjustments, the NBC users were then re-seated at their workstations, and photographs of their work postures were re-taken, to perform the posture analysis. The results show that the NBC users' work postures are improved when their NBCs and workstations are adjusted according to the recommendations. The effectiveness of ergonomic intervention is verified both visually and objectively.

The ERK pathway regulates Na(+)-HCO(3)(-) cotransport activity in adult rat cardiomyocytes.

PubMed

Baetz, Delphine; Haworth, Robert S; Avkiran, Metin; Feuvray, Danielle

2002-11-01

The sarcolemmal Na(+)-HCO cotransporter (NBC) is stimulated by intracellular acidification and acts as an acid extruder. We examined the role of the ERK pathway of the MAPK cascade as a potential mediator of NBC activation by intracellular acidification in the presence and absence of angiotensin II (ANG II) in adult rat ventricular myocytes. Intracellular pH (pH(i)) was recorded with the use of seminaphthorhodafluor-1. The NH method was used to induce an intracellular acid load. NBC activation was significantly decreased with the ERK inhibitors PD-98059 and U-0126. NBC activity after acidification was increased in the presence of ANG II (pH(i) range of 6.75-7.00). ANG II plus PD-123319 (AT(2) antagonist) still increased NBC activity, whereas ANG II plus losartan (AT(1) antagonist) did not affect it. ERK phosphorylation (measured by immunoblot analysis) during intracellular acidification was increased by ANG II, an effect that was abolished by losartan and U-0126. In conclusion, the MAPK(ERK)-dependent pathway facilitates the rate of pH(i) recovery from acid load through NBC activity and is involved in the AT(1) receptor-mediated stimulation of such activity by ANG II.

Reactive Fabrication and Effect of NbC on Microstructure and Tribological Properties of CrS Co-Based Self-Lubricating Coatings by Laser Cladding.

PubMed

Fang, Liuyang; Yan, Hua; Yao, Yansong; Zhang, Peilei; Gao, Qiushi; Qin, Yang

2017-12-28

The CrS/NbC Co-based self-lubricating composite coatings were successfully fabricated on Cr12MoV steel surface by laser clad Stellite 6, WS₂, and NbC mixed powders. The phase composition, microstructure, and tribological properties of the coatings ware investigated by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectrometer (EDS), as well as dry sliding wear testing. Based on the experimental results, it was found reactions between WS₂ and Co-based alloy powder had occurred, which generated solid-lubricant phase CrS, and NbC play a key role in improving CrS nuclear and refining microstructure of Co-based composite coating during laser cladding processing. The coatings were mainly composed of γ-Co, CrS, NbC, Cr 23 C₆, and CoC x . Due to the distribution of the relatively hard phase of NbC and the solid lubricating phase CrS, the coatings had better wear resistance. Moreover, the suitable balance of CrS and NbC was favorable for further decreasing the friction and improving the stability of the contact surfaces between the WC ball and the coatings. The microhardness, friction coefficient, and wear rate of the coating 4 (Clad powders composed of 60 wt % Stellite 6, 30 wt % NbC and 10 wt % WS₂) were 587.3 HV 0.5 , 0.426, and 5.61 × 10 -5 mm³/N·m, respectively.

Assessment of the effects of heat and NBC (nuclear, biological, and chemical) protective clothing on performance of critical military tasks. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fine, B.J.; Kobrick, J.L.

Chemical protective clothing seriously degrades the performance of soldiers doing physical work in the heat. However, little is known about the combined effects of heat and protective clothing on mental performance. This study examined the effects of heat on the sustained cognitive performance of sedentary soldiers clad in NBC protective clothing. Twenty male soldiers trained for two weeks on tasks resembling those performed by fire direction center, forward observer and communications personnel. Then, they performed the tasks for seven-hour periods on four successive days in hot (91 F, 61% RH) and normal (70 F, 35% RH or 55 F, 35%more » RH) conditions, with and without protective clothing (MOPP IV). Conclusions: The data indicate quite conclusively that after four to five hours of exposure to a moderately hot environment, the cognitive performance of a group of highly trained soldiers, clad in the MOPP IV configuration of NBC protective clothing, began to deteriorate markedly. Two individuals became heat casualties and had to be evacuated from the chamber for medical reasons. A significant number of personnel had the integrity of their protective clothing compromised by sweat after as little as three hours of exposure to heat and virtually no physical activity.« less

Reactive Fabrication and Effect of NbC on Microstructure and Tribological Properties of CrS Co-Based Self-Lubricating Coatings by Laser Cladding

PubMed Central

Fang, Liuyang; Yan, Hua; Yao, Yansong; Zhang, Peilei; Gao, Qiushi; Qin, Yang

2017-01-01

The CrS/NbC Co-based self-lubricating composite coatings were successfully fabricated on Cr12MoV steel surface by laser clad Stellite 6, WS2, and NbC mixed powders. The phase composition, microstructure, and tribological properties of the coatings ware investigated by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectrometer (EDS), as well as dry sliding wear testing. Based on the experimental results, it was found reactions between WS2 and Co-based alloy powder had occurred, which generated solid-lubricant phase CrS, and NbC play a key role in improving CrS nuclear and refining microstructure of Co-based composite coating during laser cladding processing. The coatings were mainly composed of γ-Co, CrS, NbC, Cr23C6, and CoCx. Due to the distribution of the relatively hard phase of NbC and the solid lubricating phase CrS, the coatings had better wear resistance. Moreover, the suitable balance of CrS and NbC was favorable for further decreasing the friction and improving the stability of the contact surfaces between the WC ball and the coatings. The microhardness, friction coefficient, and wear rate of the coating 4 (Clad powders composed of 60 wt % Stellite 6, 30 wt % NbC and 10 wt % WS2) were 587.3 HV0.5, 0.426, and 5.61 × 10−5 mm3/N·m, respectively. PMID:29283411

Effect of clay in controlling the non-fluorescence H-dimeric states of a cationic dye Nile Blue Chloride (NBC) in hybrid Langmuir-Blodgett (LB) film

NASA Astrophysics Data System (ADS)

Debnath, Chandan; Shil, Ashis; Hussain, S. A.; Bhattacharjee, D.

2018-01-01

Present communication reports the effect of amphiphilic matrices and nano-clay platelets on the aggregation properties of a water soluble cationic fluorescent dye Nile Blue Chloride (NBC) in Langmuir-Blodgett (LB) films. In-situ Brewster Angle Microscopic (BAM) studies showed distinct domain structures of complex and hybrid Langmuir monolayer at the air-water interface. UV-vis absorption spectra showed non-fluorescent H-dimeric band in concentrated aqueous solution of NBC and in complex LB film of NBC with stearic acid. By changing various parameters, a great control over H-dimeric states has been achieved in clay incorporated hybrid LB films. These films can act as efficient fluorescence probe.

Measurement of fuel corrosion products using planar laser-induced fluorescence

NASA Astrophysics Data System (ADS)

Wantuck, Paul J.; Sappey, Andrew D.; Butt, Darryl P.

1993-01-01

Characterizing the corrosion behavior of nuclear fuel material in a high-temperature hydrogen environment is critical for ascertaining the operational performance of proposed nuclear thermal propulsion (NTP) concepts. In this paper, we describe an experimental study undertaken to develop and test non-intrusive, laser-based diagnostics for ultimately measuring the distribution of key gas-phase corrosion products expected to evolve during the exposure of NTP fuel to hydrogen. A laser ablation technique is used to produce high temperature, vapor plumes from uranium-free zirconium carbide (ZrC) and niobium carbide (NbC) forms for probing by various optical diagnostics including planar laser-induced fluorescence (PLIF). We discuss the laser ablation technique, results of plume emission measurements, and we describe both the actual and proposed planar LIF schemes for imaging constituents of the ablated ZrC and NbC plumes. Envisioned testing of the laser technique in rf-heated, high temperature gas streams is also discussed.

[Genetic structure of people from the Volga-Ural region and Central Asia from data of Alu-polymorphism].

PubMed

Khusainova, R I; Akhmetova, V L; Kutuev, I A; Salimova, A Z; Korshunova, T Iu; Lebedev, Iu B; Khusnutdinova, E K

2004-04-01

Nine Alu loci (Ya5NBC5, Ya5NBC27, Ya5NBC148, Ya5NBC182, YA5NBC361, ACE, ApoA1, PV92, TPA25) were analyzed in six ethnic populations (Trans-Ural Bashkirs, Tatars-Mishars, Mordovians-Moksha, Mountain Maris, Udmurts, and Komi-Permyaks) of the Volga-Ural region and in three Central Asian populations (Uzbeks, Kazakhs, and Uigurs). All Alu insertions analyzed appeared to be polymorphic in all populations examined. The frequency of insertion varied from 0.110 in Mountain Maris at the Ya5NBC5 locus to 0.914 in Tatars at the ApoA1 locus. The data on the allele frequency distribution at nine loci point to the existence of substantial genetic diversity in the populations examined. The value of the observed heterozygosity averaged over nine Alu insertions varied from 0.326 in Mountain Maris to 0.445 in Kazakhs and Uigurs. The level of the interpopulation genetic differences for the Volga-Ural population (Fst = 0.061) was higher than for the populations of Central Asia (Fst = 0.024), Europe (Fst = 0.02), and Southeastern Asia (Fst = 0.018). The populations examined were highly differentiated both in respect of linguistic characteristics and the geographical position. The data obtained confirmed the effectiveness of the marker system used for the assessment of genetic differentiation and the relationships between the ethnic groups.

Christopher W. Johnson | NREL

Science.gov Websites

the marketplace. Education Ph.D., Molecular Biology, University of Colorado - Anschutz Medical Campus , NREL, NBC, 2015-present Postdoctoral Researcher, NREL, NBC, 2012-2015 Molecular Biologist, Gevo, 2011

NBC detection in air and water

NASA Technical Reports Server (NTRS)

Hartley, Frank T.; Smith, Steven J.; McMurtry, Gary M.

2003-01-01

Participating in a Navy STTR project to develop a system capable of the 'real-time' detection and quanitification of nuclear, biological and chemical (NBC) warfare agents, and of related industrial chemicals including NBC agent synthesis by-products in water and in air immediately above the water's surface. This project uses JPL's Soft Ionization Membrane (SIM) technology which totally ionizes molecules without fragmentation (a process that can markedly improve the sensitivity and specificity of molecule compostition identification), and JPL's Rotating Field Mass Spectrometer (RFMS) technology which has large enough dynamic mass range to enable detection of nuclear materials as well as biological and chemical agents. This Navy project integrates these JPL Environmental Monitoring UnitS (REMUS) an autonomous underwater vehicle (AUV). It is anticipated that the REMUS AUV will be capable of 'real-time' detection and quantification of NBC warefare agents.

[Analysis of Alu-insertion polymorphism in three subethnic groups of Kalmyks].

PubMed

Khusainova, R I; Balinova, N V; Kutuev, I A; Spitsina, N Kh; Akhmetova, V L; Valiev, R R; Spitsyn, V A; Khusnutdinova, E K

2009-03-01

Eight Alu insertions at the NBC27, TPA25, NBC148, NBC123, ACE, APOA1, NBC51, and PV92 locus were examined in three subethnic groups of Kalmyks (Torgouds, Derbets, and Buzava). In general, the pattern of allele frequencies in Kalmyks was consistent with that in Asian populations of the world, and was similar to the Alu insertion frequencies pattern in Turkic populations of the Volga--Ural region and Central Asia. Pairwise comparisons of three subpopulations of Kalmyks with respect to the frequency distributions of eight Alu insertions revealed the differences between the groups examined. The coefficient of gene differentiation, F(st), constituted 1.37%, pointing to the common origin of the groups of interest, as well as to the uniformity of the gene pools of subethnic groups of Kalmyks examined.

Implementing Nepal's national building code—A case study in patience and persistence

USGS Publications Warehouse

Arendt, Lucy; Hortacsu, Ayse; Jaiswal, Kishor; Bevington, John; Shrestha, Surya; Lanning, Forrest; Mentor-William, Garmalia; Naeem, Ghazala; Thibert, Kate

2017-01-01

The April 2015 Gorkha Nepal earthquake revealed the relative effectiveness of the Nepal Standard, or national building code (NBC), and irregular compliance with it in different parts of Nepal. Much of the damage to more than half a million Nepal's residential structures may be attributed to the prevalence of owner-built or owner-supervised construction and the lack of owner and builder responsiveness to seismic risk and training in the appropriate means of complying with the NBC. To explain these circumstances, we review the protracted implementation of the NBC and the role played by one organization, the National Society for Earthquake Technology-Nepal (NSET), in the NBC's implementation. We also share observations on building code compliance made by individuals in Nepal participating in workshops led by the Earthquake Engineering Research Institute's 2014 class of Housner Fellows.

Comparison of projection skills of deterministic ensemble methods using pseudo-simulation data generated from multivariate Gaussian distribution

NASA Astrophysics Data System (ADS)

Oh, Seok-Geun; Suh, Myoung-Seok

2017-07-01

The projection skills of five ensemble methods were analyzed according to simulation skills, training period, and ensemble members, using 198 sets of pseudo-simulation data (PSD) produced by random number generation assuming the simulated temperature of regional climate models. The PSD sets were classified into 18 categories according to the relative magnitude of bias, variance ratio, and correlation coefficient, where each category had 11 sets (including 1 truth set) with 50 samples. The ensemble methods used were as follows: equal weighted averaging without bias correction (EWA_NBC), EWA with bias correction (EWA_WBC), weighted ensemble averaging based on root mean square errors and correlation (WEA_RAC), WEA based on the Taylor score (WEA_Tay), and multivariate linear regression (Mul_Reg). The projection skills of the ensemble methods improved generally as compared with the best member for each category. However, their projection skills are significantly affected by the simulation skills of the ensemble member. The weighted ensemble methods showed better projection skills than non-weighted methods, in particular, for the PSD categories having systematic biases and various correlation coefficients. The EWA_NBC showed considerably lower projection skills than the other methods, in particular, for the PSD categories with systematic biases. Although Mul_Reg showed relatively good skills, it showed strong sensitivity to the PSD categories, training periods, and number of members. On the other hand, the WEA_Tay and WEA_RAC showed relatively superior skills in both the accuracy and reliability for all the sensitivity experiments. This indicates that WEA_Tay and WEA_RAC are applicable even for simulation data with systematic biases, a short training period, and a small number of ensemble members.

Effects of Wearing NBC (Nuclear, Biological and Chemical) Protective Clothing in the Heat on Detection of Visual Signals

DTIC Science & Technology

1985-02-01

agents, as well as nuclear weaponry. In the face of’ such threats, the United States Army has developed equinment and clothing systems designed to...AD_ REPORT NO. T7185 EFFECTS OF WEARING NBC PROTECTIVE CLOTHING IN THE HEAT ON DETECTION OF VISUAL SIGNALS U S ARMY RESEARCH INSTITUTE N OF...CATALOG NUMBER T7/•5 ( 4. TITLE (and Subtitle) 5. TYPE OF REPORT & PERIOD COVERED Effects of Wearing NBC Protective Clothing in the Technical Report Heat

Test Results of Air-Permeable Charcoal Impregnated Suits to Challenge by Chemical and Biological Warfare Agents and Simulants. Executive Summary and Summary Report

DTIC Science & Technology

2003-05-01

authorizing documents. REPORT DOCUMENTATION PAGE F ~ormApprove I OMB No. 0704-0188 Public reporting burden for this collection of Information Is...Health, San Antonio, TX e Dr. Annetta P. Watson, Life Sciences Division, Oak Ridge National Laboratories, Oak Ridge, TN 9 Leo F . Saubier, Battelle Memorial...37 F - Giat NBC SWAT Suit ........................................................... 43 G - Giat

Multi-component Cu-Strengthened Steel Welding Simulations: Atom Probe Tomography and Synchrotron X-ray Diffraction Analyses

NASA Astrophysics Data System (ADS)

Hunter, Allen H.; Farren, Jeffrey D.; DuPont, John N.; Seidman, David N.

2015-07-01

An experimental steel with the composition Fe-1.39Cu-2.70Ni-0.58Al-0.48Mn-0.48Si-0.065Nb-0.05C (wt pct) or alternatively Fe-1.43Cu-2.61Ni-1.21Al-0.48Mn-0.98Si-0.039Nb-0.23C (at. pct) has been developed at Northwestern University, which has both high toughness and high strength after quenching and aging treatments. Simulated heat-affected zone (HAZ) samples are utilized to analyze the microstructures typically obtained after gas metal arc welding (GMAW). Dissolution within the HAZ of cementite (Fe3C) and NbC (F.C.C.) is revealed using synchrotron X-ray diffraction, while dissolution of Cu precipitates is measured employing local electrode atom probe tomography. The results are compared to Thermo-Calc equilibrium calculations. Comparison of measured Cu precipitate radii, number density, and volume fraction with similar measurements from a GMAW sample suggests that the cooling rate in the simulations is faster than in the experimental GMAW sample, resulting in significantly less Cu precipitate nucleation and growth during the cooling part of the weld thermal cycle. The few Cu precipitates detected in the simulated samples are primarily located on grain boundaries resulting from heterogeneous nucleation. The dissolution of NbC precipitates and the resultant austenite coarsening in the highest-temperature sample, coupled with a rapid cooling rate, results in the growth of bainite, and an increase in the strength of the matrix in the absence of significant Cu precipitation.

Synthesis and structure of the first discrete dinuclear cationic aluminum complexes.

PubMed

Wang, Xingbao; Dorcet, Vincent; Luo, Yi; Carpentier, Jean-Francois; Kirillov, Evgueni

2016-08-02

The reactions of the charge neutral dinuclear aluminum tetraalkyl complexes of di-Schiff base ligands, i.e. [AlMe2{ON}-R-{ON}AlMe2] (1a, R = 1,3-propylene; 1b, R = 1,3-cyclohexylene) with B(C6F5)3 and [H(Et2O)2](+)[H2N{B(C6F5)3}2](-) were investigated. When B(C6F5)3 was used as the cationizing agent (1 or 2 equiv. vs. Al), only monocationic dinuclear complexes [2a,b]+[MeB(C6F5)3]- were obtained. In contrast, with [H(Et2O)2](+)[H2N{B(C6F5)3}2](-), both mixed-dicationic [3a,b·(OEt2)2]2+[MeB(C6F5)3]-[H2N{B(C6F5)3}2]- and homo-dicationic [3a,b·(OEt2)2]2+[H2N{B(C6F5)3}2]-2 ion-pairs were prepared. All cationic complexes were characterized by (1)H, (13)C, (19)F and (11)B NMR spectroscopy, and an X-ray diffraction study was performed for [3b·(OEt2)2]2+[H2N{B(C6F5)3}2]-2.

"Dateline NBC"'s Persuasive Attack on Wal-Mart.

ERIC Educational Resources Information Center

Benoit, William L.; Dorries, Bruce

1996-01-01

Develops a typology of persuasive attack strategies. Identifies two key components of persuasive attack: responsibility and offensiveness. Describes several strategies for intensifying each of these elements. Applies this analysis to "Dateline NBC"'s allegations that Wal-Mart's "Buy American" campaign was deceptive. Concludes…

Development of a five-year mortality model in systemic sclerosis patients by different analytical approaches.

PubMed

Beretta, Lorenzo; Santaniello, Alessandro; Cappiello, Francesca; Chawla, Nitesh V; Vonk, Madelon C; Carreira, Patricia E; Allanore, Yannick; Popa-Diaconu, D A; Cossu, Marta; Bertolotti, Francesca; Ferraccioli, Gianfranco; Mazzone, Antonino; Scorza, Raffaella

2010-01-01

Systemic sclerosis (SSc) is a multiorgan disease with high mortality rates. Several clinical features have been associated with poor survival in different populations of SSc patients, but no clear and reproducible prognostic model to assess individual survival prediction in scleroderma patients has ever been developed. We used Cox regression and three data mining-based classifiers (Naïve Bayes Classifier [NBC], Random Forests [RND-F] and logistic regression [Log-Reg]) to develop a robust and reproducible 5-year prognostic model. All the models were built and internally validated by means of 5-fold cross-validation on a population of 558 Italian SSc patients. Their predictive ability and capability of generalisation was then tested on an independent population of 356 patients recruited from 5 external centres and finally compared to the predictions made by two SSc domain experts on the same population. The NBC outperformed the Cox-based classifier and the other data mining algorithms after internal cross-validation (area under receiving operator characteristic curve, AUROC: NBC=0.759; RND-F=0.736; Log-Reg=0.754 and Cox= 0.724). The NBC had also a remarkable and better trade-off between sensitivity and specificity (e.g. Balanced accuracy, BA) than the Cox-based classifier, when tested on an independent population of SSc patients (BA: NBC=0.769, Cox=0.622). The NBC was also superior to domain experts in predicting 5-year survival in this population (AUROC=0.829 vs. AUROC=0.788 and BA=0.769 vs. BA=0.67). We provide a model to make consistent 5-year prognostic predictions in SSc patients. Its internal validity, as well as capability of generalisation and reduced uncertainty compared to human experts support its use at bedside. Available at: http://www.nd.edu/~nchawla/survival.xls.

Experimental study of dual polarized radar return from the sea surface

NASA Astrophysics Data System (ADS)

Ermakov, S. A.; Kapustin, I. A.; Lavrova, O. Yu.; Molkov, A. A.; Sergievskaya, I. A.; Shomina, O. V.

2017-10-01

Dual-polarized microwave radars are of particular interest nowadays as perspective tool of ocean remote sensing. Microwave radar backscattering at moderate and large incidence angles according to conventional models is determined by resonance (Bragg) surface waves typically of cm-scale wavelength range. Some recent experiments have indicated, however, that an additional, non Bragg component (NBC) contributes to the radar return. The latter is considered to occur due to wave breaking. At present our understanding of the nature of different components of radar return is still poor. This paper presents results of field experiment using an X-/C-/S-band Doppler radar operating at HH- and VVpolarizations. The intensity and radar Doppler shifts for Bragg and non Bragg components are retrieved from measurements of VV and HH radar returns. Analysis of a ratio of VV and HH radar backscatter - polarization ratio (PR) has demonstrated a significant role of a non Bragg component. NBC contributes significantly to the total radar backscatter, in particular, at moderate incidence angles (about 50-70 deg.) it is 2-3 times smaller than VV Bragg component and several times larger that HH Bragg component. Both NBC and BC depend on azimuth angle, being minimal for cross wind direction, but NBC is more isotropic than BC. It is obtained that velocities of scatterers retrieved from radar Doppler shifts are different for Bragg waves and for non Bragg component; NBC structures are "faster" than Bragg waves particularly for upwind radar observations. Bragg components propagate approximately with phase velocities of linear gravity-capillary waves (when accounting for wind drift). Velocities of NBC scatterers depend on radar band, being the largest for S-band and the smallest at X-band, this means that different structures on the water surface are responsible for non Bragg scattering in a given radar band.

Electrochemical Synthesis of Core-Shell-Structured NbC-Fe Composite Powder for Enforcement in Low-Carbon Steel.

PubMed

Li, Hongmei; Song, Qiushi; Xu, Qian; Chen, Ying; Xu, Liang; Man, Tiannan

2017-11-01

An NbC-Fe composite powder was synthesized from an Nb₂O₅/Fe/C mixture by electrochemical reduction and subsequent carbonization in molten CaCl₂-NaCl. The composite has a core-shell structure, in which NbC acts as the cores distributing in the Fe matrix. A strong bonding between NbC and Fe is benefit from the core-shell structure. The sintering and electrochemical reduction processes were investigated to probe the mechanism for the reactions. The results show that NbC particles about several nanometers were embraced by the Fe shell to form a composite about 100 nm in size. This featured structure can feasibly improve the wettability and sinterability of NbC as well as the uniform distribution of the carbide in the cast steel. By adding the composite into steel in the casting process, the grain size of the casted steel was markedly deceased from 1 mm to 500 μm on average, favoring the hardening of the casted steel.

The critical role of the Poison Center in the recognition, mitigation and management of biological and chemical terrorism.

PubMed

Krenzelok, E P

2001-01-01

Nuclear, biological and chemical (NBC) terrorism counter measures are a major priority with healthcare providers, municipalities, states and the federal government. Significant resources are being invested to enhance civilian domestic preparedness through training in anticipation of a NBC terroristic incident. The key to a successful response, in addition to education, is integration of efforts as well as thorough communication and understanding the role that each agency would play in an actual or impending NBC incident. In anticipation of a NBC event, a regional counter-terrorism task force was established in southwestern Pennsylvania to identify resources, establish responsibilities and coordinate the response to NBC terrorism. Members of the task force include first responders, hazmat, law enforcement (local, regional, national), government officials, health departments, the statewide emergency management agency and the regional poison information center. The poison center is one of several critical components of a regional counter-terrorism response force. It can conduct active and passive toxicosurveillance and identify sentinel events. To be responsive, the poison center staff must be knowledgeable about biological and chemical agents. The development of basic protocols and a standardized staff education program is essential. The use of the RaPID-T (R-recognition, P-protection, D-detection, T-triage/treatment) course can provide basic staff education for responding to this important but rare consultation to the poison center.

Amazon water lenses and the influence of the North Brazil Current on the continental shelf

NASA Astrophysics Data System (ADS)

Prestes, Yuri O.; Silva, Alex Costa da; Jeandel, Catherine

2018-05-01

The exchange processes on the Amazon continental shelf in northern Brazil are subject to complex interactions that involve forcings derived from distinct sources. The Amazon shelf is a unique and highly dynamic environment in which considerable discharge of freshwater enters the Atlantic Ocean, producing extensive Amazon Water Lenses (AWL). In addition to the presence of the AWL, the shelf is influenced by the semidiurnal oscillations of the tides and the strong North Brazil Current (NBC), a boundary current of the western Atlantic. The present study was based primarily on the influence of the freshwater input and the NBC on the shelf and the Amazon Shelf Break (ASB) off the mouth of the Pará River. For this purpose, hydrographic and hydrodynamic data were obtained by moorings of the AMANDES Project (April-July 2008), located on the Amazon shelf and the ASB. Spectral analysis and the continuous wavelet transform were applied to define tidal (high frequency/short period) and subtidal (low frequency/long period) signals. The results indicated that on both the shelf and the break, the semidiurnal tides are responsible for the residual landward transport and are predominantly across-shelf. Low-frequency motions in the synoptic bands and the AWL are related to spatial changes in the velocity field, mainly on the ASB in the along-shelf direction. The flow of the NBC can be interpreted as an along-shelf low-frequency oscillation capable of altering the spatial configuration of the velocity field, although its influence is perceived only in the absence of the AWL.

Linking Automated Systems in North Bay Libraries.

ERIC Educational Resources Information Center

Bruman, Janet

This report addresses alternative means of interconnecting or providing access to the various automated systems within the 17-member North Bay Cooperative Library System (NBC), with emphasis on providing information on the availability of materials for loan, the principal objective of the NBC Telecommunications Project, Year Two. Advantages and…

Using Social Science to Improve Children's Television: An NBC Case Study.

ERIC Educational Resources Information Center

Stipp, Horst; And Others

1987-01-01

Describes the evolution and activities of the Social Science Advisory Panel at NBC (National Broadcasting Company) that brings knowledge about children and television to the production of Saturday morning children's television programs. Highlights include self-regulatory aspects of the panel, issues confronted such as violence and stereotyping,…

Report on Activities and Programs for Countering Proliferation and NBC Terrorism. Volume 1, Executive Summary, Addendum to 2011 Report

DTIC Science & Technology

2013-06-01

Executive Branch report on research , development, and acquisition (RDA) programs to Combat Weapons of Mass Destruction (WMD). Other interagency committees...characterize, secure, disable , and/or destroy a state or non-state actor’s WMD programs and related capabilities in hostile or uncertain environments. Threat...special operations, and security operations to defend against conventionally and unconventionally delivered WMD. WMD Consequence Management. Actions

NBC Contamination Survivability, Large Item Exteriors

DTIC Science & Technology

1998-04-17

environment. Ability to control temperature , relative humidity (RH), and wind speed is required. The facility must be designed to ensure safe and...2.2 Instrumentation. Measuring Devices Permissible Error of Measurement Air temperature ±0.5°C Relative humidity (RH) ±5 % Wind speed ±0.1 rm/sec Still...process, excluding monitoring, should last no longer than 75 minutes. (3) The item surface temperature is 30’C and exterior wind speed is no greater

Gas Testing at the NBC-Filter of the M-Frigates of the Royal Dutch Navy According to the NATO Standard (Gastesten aan het NBC-Filter voor het M-Fregat van de oninklijke Marine volgens NAVO-eisen)

DTIC Science & Technology

1992-06-01

man de eisen van bet NAVO.-document voldsan word.. Het AstroCarb-filter bleek voor alle geteste gassen gemakkelijk de vereiste doorbroaktijden te halen ...hill ?NO famwtyn J-3r d~mf tI~nq"M#-rI~ m t~w)-im TNO RCl1 U W2 AM " TNO-por PML1 32490333 Pagins 2 Samenvatting De gasbescherniende eigenschappen van ...De schoktest tastte de prestaties van bet filter niet man. Summary The gas protective properties of an AstroCarb 200 NBC filter which is usid in the

Environmental Health Monitor: Advanced Development of Temperature Sensor Suite. Phase 2

DTIC Science & Technology

1994-07-30

34Simulated Approach Marches During Thermal Stress: a P2 NBC2 Study," US Army Research Institute of Environmental Medicine, Natick, MA 01750-5007...parameters. 1.2 Purpose of the Present Work The specific purpose of the present SBIR program is to generate a compact sensor suite capable of measuring...has a number of stressors which are likely to affect his success. The approached the difficulty of dealing with effects of heat, clothing, and

75 FR 26100 - Danger Zone, Pacific Ocean, Naval Base Coronado, Coronado, California

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

..., Pacific Ocean, Naval Base Coronado, Coronado, California AGENCY: U.S. Army Corps of Engineers, DoD. ACTION... Naval Base Coronado (NBC), in Coronado, San Diego County, California. The danger zone will provide..., Naval Base Coronado (NBC), has requested that the Corps establish a danger zone in the waters of the...

Growth mechanism, distribution characteristics and reinforcing behavior of (Ti, Nb)C particle in laser cladded Fe-based composite coating

NASA Astrophysics Data System (ADS)

Li, Qingtang; Lei, Yongping; Fu, Hanguang

2014-10-01

Over the past decade, researchers have demonstrated much interest in laser cladded metal matrix composite coatings for its good wear resistance, corrosion resistance, and high temperature properties. In this paper, in-situ (Ti, Nb)C particle reinforced Fe-based composite coatings were produced by laser cladding. The effects of Ti/Nb(atomic ratio) in the cladding powder on the formation mechanism and distribution characteristics of multiple particle were investigated. The results showed that when Ti/Nb > 1, Ti had a stronger ability to bond with C compared with Nb. (Ti, Nb)C multiple particles with TiC core formed in the molten pool. With the decrease of Ti/Nb, core-shell structure disappeared, the structure of particle got close to that of NbC gradually. It is found that the amount, area ratio and distribution of the reinforced particle in the coating containing Ti and Nb elements were improved, compared with these in the coating containing equal Nb element. When Ti/Nb = 1, the effects above-mentioned is most prominent, and the wear resistance of the coating is promoted obviously.

Boron-Based Inhibitors of the NLRP3 Inflammasome.

PubMed

Baldwin, Alex G; Rivers-Auty, Jack; Daniels, Michael J D; White, Claire S; Schwalbe, Carl H; Schilling, Tom; Hammadi, Halah; Jaiyong, Panichakorn; Spencer, Nicholas G; England, Hazel; Luheshi, Nadia M; Kadirvel, Manikandan; Lawrence, Catherine B; Rothwell, Nancy J; Harte, Michael K; Bryce, Richard A; Allan, Stuart M; Eder, Claudia; Freeman, Sally; Brough, David

2017-11-16

NLRP3 is a receptor important for host responses to infection, yet is also known to contribute to devastating diseases such as Alzheimer's disease, diabetes, atherosclerosis, and others, making inhibitors for NLRP3 sought after. One of the inhibitors currently in use is 2-aminoethoxy diphenylborinate (2APB). Unfortunately, in addition to inhibiting NLRP3, 2APB also displays non-selective effects on cellular Ca 2+ homeostasis. Here, we use 2APB as a chemical scaffold to build a series of inhibitors, the NBC series, which inhibit the NLRP3 inflammasome in vitro and in vivo without affecting Ca 2+ homeostasis. The core chemical insight of this work is that the oxazaborine ring is a critical feature of the NBC series, and the main biological insight the use of NBC inhibitors led to was that NLRP3 inflammasome activation was independent of Ca 2+ . The NBC compounds represent useful tools to dissect NLRP3 function, and may lead to oxazaborine ring-containing therapeutics. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Electrochemical Synthesis of Core–Shell-Structured NbC–Fe Composite Powder for Enforcement in Low-Carbon Steel

PubMed Central

Song, Qiushi; Xu, Qian; Chen, Ying; Xu, Liang; Man, Tiannan

2017-01-01

An NbC–Fe composite powder was synthesized from an Nb2O5/Fe/C mixture by electrochemical reduction and subsequent carbonization in molten CaCl2–NaCl. The composite has a core–shell structure, in which NbC acts as the cores distributing in the Fe matrix. A strong bonding between NbC and Fe is benefit from the core–shell structure. The sintering and electrochemical reduction processes were investigated to probe the mechanism for the reactions. The results show that NbC particles about several nanometers were embraced by the Fe shell to form a composite about 100 nm in size. This featured structure can feasibly improve the wettability and sinterability of NbC as well as the uniform distribution of the carbide in the cast steel. By adding the composite into steel in the casting process, the grain size of the casted steel was markedly deceased from 1 mm to 500 μm on average, favoring the hardening of the casted steel. PMID:29104266

Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone.

PubMed

Draz, Mohamed Shehata; Lakshminaraasimulu, Nivethitha Kota; Krishnakumar, Sanchana; Battalapalli, Dheerendranath; Vasan, Anish; Kanakasabapathy, Manoj Kumar; Sreeram, Aparna; Kallakuri, Shantanu; Thirumalaraju, Prudhvi; Li, Yudong; Hua, Stephane; Yu, Xu G; Kuritzkes, Daniel R; Shafiee, Hadi

2018-05-16

Zika virus (ZIKV) infection is an emerging pandemic threat to humans that can be fatal in newborns. Advances in digital health systems and nanoparticles can facilitate the development of sensitive and portable detection technologies for timely management of emerging viral infections. Here we report a nanomotor-based bead-motion cellphone (NBC) system for the immunological detection of ZIKV. The presence of virus in a testing sample results in the accumulation of platinum (Pt)-nanomotors on the surface of beads, causing their motion in H 2 O 2 solution. Then the virus concentration is detected in correlation with the change in beads motion. The developed NBC system was capable of detecting ZIKV in samples with virus concentrations as low as 1 particle/μL. The NBC system allowed a highly specific detection of ZIKV in the presence of the closely related dengue virus and other neurotropic viruses, such as herpes simplex virus type 1 and human cytomegalovirus. The NBC platform technology has the potential to be used in the development of point-of-care diagnostics for pathogen detection and disease management in developed and developing countries.

Hydrogen sulfide upregulated mRNA expressions of sodium bicarbonate cotransporter1, trefoil factor1 and trefoil factor2 in gastric mucosa in rats.

PubMed

Cheraghi, Parisa; Mard, Seyyed Ali; Nagi, Tahereh

2016-01-01

Hydrogen sulfide (H 2 S) has been shown to protect the gastric mucosa through several protective mechanisms but till now its effect on mRNA expression of sodium bicarbonate cotransporter 1 (NBC1), trefoil factor1 (TFF1) and trefoil factor2 (TFF2) was not investigated. This study was aimed to evaluate the effect of H 2 S on mRNA expression of NBC1, TFF1 and TFF2 in rat gastric mucosa in response to gastric distention. Thirty two rats were randomly assigned into four equal groups. They were control (C), distention (D), propargylglycine (PAG)-, and NaHS-treated groups. To evaluate the effect of exogenous and endogenous H 2 S on gene expression of NBC1, TFF1 and TFF2, two groups of rats were received H 2 S donor, intra-peritoneal NaHS (80 µg Kg -1 ), and PAG (50 mg kg -1 ), accompanied to stimulate the gastric acid secretion, respectively. Under general anesthesia and laparotomy, a catheter was inserted into the stomach through duodenum for instillation of isotonic saline for gastric distention. Ninety min after beginning the experiment, animals were sacrificed and the gastric mucosa was collected to determine total acid content of gastric effluents and to quantify the mRNA expression of studied genes by quantitative real-time polymerase chain reaction (qRT-PCR). Results showed that A) gastric distention increased the level of mRNA expressions of NBC1, TFF1 and TFF2; B) these levels in NaHS-treated rats were significantly higher than those in Distention group; and C) PAG decreased the expression levels of NBC1 and TFF1. The Findings showed H 2 S upregulated gene expression of NBC1, TFF1 and TFF2 in gastric mucosa.

The poison center role in biological and chemical terrorism.

PubMed

Krenzelok, E P; Allswede, M P; Mrvos, R

2000-10-01

Nuclear, biological and chemical (NBC) terrorism countermeasures are a major priority with municipalities, healthcare providers, and the federal government. Significant resources are being invested to enhance civilian domestic preparedness by conducting education at every response level in anticipation of a NBC terroristic incident. The key to a successful response, in addition to education, is integration of efforts as well as thorough communication and understanding the role that each agency would play in an actual or impending NBC incident. In anticipation of a NBC event, a regional counter-terrorism task force was established to identify resources, establish responsibilities and coordinate the response to NBC terrorism. Members of the task force included first responders, hazmat, law enforcement (local, regional, national), government officials, the health department, and the regional poison information center. Response protocols were developed and education was conducted, culminating in all members of the response task force becoming certified NBC instructors. The poison center participated actively in 3 incidents of suspected biologic and chemical terrorism: an alleged anthrax-contaminated letter sent to a women's health clinic; a possible sarin gas release in a high school: and a potential anthrax/ebola contamination incident at an international airport. All incidents were determined hoaxes. The regional response plan establishes the poison information center as a common repository for all cases in a biological or chemical incident. The poison center is one of several critical components of a regional counterterrorism response force. It can conduct active and passive toxicosurveillance and identify sentinel events. To be responsive, the poison center staff must be knowledgeable about biological and chemical agents. The development of basic protocols and a standardized staff education program is essential. The use of the RaPiD-T (R-recognition, P-protection, D-detection, T-triage/treatment) course can provide basic staff education for responding to this important but rare consultation to the poison center.

Proceedings of the USAF/NATO Conference on Maintenance of Air Base Operations in a Chemical Warfare Environment Held in Williamsburg, Virginia on August - September 1987

DTIC Science & Technology

1987-09-01

46* The Nuclear, Biological and Chemical lLerservice Working Party -- The US Services NBC Operational Access to NATO - Major Robert J . Kainz...47 Avionics Decontamination Program - Captain Candice J . Tomlinson ............ 55 U S Army Decontamination Program Overview - Dr. James A. Baker...Respiratory Protection Program - Mr. Robert Tompkins .......... 228 Netherlands Chemical Defense Gear for F-16 Pilots - Dr. J . Medema ......... 233

Effects of Network Commentary on Viewers' Reactions to 1984 Reagan Campaign Film.

ERIC Educational Resources Information Center

Gerhard, Mike; Loving, Jim

A study was conducted to examine the effects of NBC television's critical commentary on a 12-minute 1984 Reagan campaign film on audience perceptions of gratifications received from the film. It was predicted that exposure to the critical NBC commentary would result in lower evaluations of the film's helpfulness (gratifications received), and that…

Morphological Effect of Pd Catalyst on Ethanol Electro-Oxidation Reaction

PubMed Central

Cerritos, Raúl Carrera; Guerra-Balcázar, Minerva; Ramírez, Rosalba Fuentes; Ledesma-García, Janet; Arriaga, Luis Gerardo

2012-01-01

In the present study, three different structures with preferentially exposed crystal faces were supported on commercial carbon black by the polyol method (nanoparticles (NP/C), nanobars (NB/C) and nanorods (NR/C)). The electrocatalysts were characterized by XRD, TEM, TGA and cyclic voltammetry at three different ethanol concentrations. Considerable differences were found in terms of catalytic electroactivity. At all ethanol concentrations, the trend observed for the ethanol oxidation peak potential was preserved as follows: NB/C < NP/C< NR/C < commercial Pd/C. This result indicates that, from a thermodynamics point of view, the NB/C catalyst enclosed by Pd(100) facets presented the highest activity with respect to ethanol electro-oxidation among all of the catalysts studied.

Test Results of Air-Permeable Charcoal Impregnated Suits to Challenge by Chemical and Biological Warfare Agents and Simulants: Summary Report

DTIC Science & Technology

2002-09-01

Area M ) + 0.4(Thigh Area M ) + 0.05(Upper Arm Seam M ) + 0.05(Lower Leg Seam M ) + 0.1(Crotch Area M ). f f f f f 428 53971 61240 454 24385 ...Public Health, San Antonio, TX • Annetta P. Watson, Ph.D., Life Sciences Div., Oak Ridge National Laboratories, Oak Ridge, TN • Leo F . Saubier...TOMPS) ……………………….. 35 F Giat NBC SWAT Suit

13. NBS LOWER ROOM. BEHIND FAR GLASS WALL IS VIDEO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. NBS LOWER ROOM. BEHIND FAR GLASS WALL IS VIDEO TAPE EQUIPMENT AND VOICE INTERCOM EQUIPMENT. THE MONITORS ABOVE GLASS WALL DISPLAY UNDERWATER TEST VIDEO TO CONTROL ROOM. FARTHEST CONSOLE ROW CONTAINS CAMERA SWITCHING, PANNING, TILTING, FOCUSING, AND ZOOMING. MIDDLE CONSOLE ROW CONTAINS TEST CONDUCTOR CONSOLES FOR MONITORING TEST ACTIVITIES AND DATA. THE CLOSEST CONSOLE ROW IS NBC FACILITY CONSOLES FOR TEST DIRECTOR, SAFETY AND QUALITY ASSURANCE REPRESENTATIVES. - Marshall Space Flight Center, Neutral Buoyancy Simulator Facility, Rideout Road, Huntsville, Madison County, AL

Strategic forum. Number 70. Regional deterrence strategies for new proliferation threats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kahan, J.H.

1996-04-01

The deterrence of armed aggression against the United States, its vital national interests, or its allies has moved beyond the requirements of conventional force deterrence. The proliferation of nuclear, biological, and chemical (NBC) weapons requires a new strategy to ensure effective deterrence against their use by regional states that could not win in a conventional conflict with the United States. Because proliferation has expanded to a number of regional actors, a single strategy is unlikely to be sufficient in deterring states with varied motivations, and social, economic, religious, cultural, and political backgrounds. The Unified Commands-principally the Pacific, Central and Europeanmore » Commands- provide a ready-made framework in which general U.S. deterrence strategies can be tailored to each proliferant state While the Unified Commands would shape the individual deterrence strategies, the national command authority (NCA) would retain control of key decisions. Guidelines for NBC regional deterrence should include developing credible counterproliferation postures, profiling potential adversaries, tailoring our military capabilities to specific threats, integrating NBC preparedness into exercises and warplans, and actively pursuing coalitions designed to deter regional proliferators from threatening to use or using NBC weapons.« less

Strike Rescue - Are We on the Right Path?

DTIC Science & Technology

1990-11-16

Vietnam, a pilot had more to worry about than just enemy SAM’s and flak. More than one POW was bagged by his own weapon system. CDR Jeremiah A. Denton ...Squadron (SOS) based at Eglin AFB in Florida. The MH-60G features an air-to-air refueling probe and auxiliary internal fuel tanks. This allows for 4.5...missions in a contaminated NBC environment. Specifically, let’s consider SC𔄁 missions to rescue "human shields" that Hussein has inserted to protect

JPRS Report, West Europe, Reference Aid, Glossary of Acronyms and Abbreviations of Norway

DTIC Science & Technology

1989-04-04

nuclear-biological- chemical [use NBC] ABC/S Forsvarets ABC-sekretariat Defense NBC Secretariat adj . adjutant adm administrasj on adm...institusj onens regneanlegg kjem kjemi(sk) kj. st. kj^restilling Kjeller Institute Computing Facility chemical driving position kjt kj...National Federation of the Chemical Mineral Industry Air Commander, North Norway LKR lett kontrollrom LKS Luftkommandor S0r-Norge LK-sjef

Modelling of Heat and Moisture Loss Through NBC Ensembles

DTIC Science & Technology

1991-11-01

the heat and moisture transport through various NBC clothing ensembles. The analysis involves simplifying the three dimensional physical problem of... clothing on a person to that of a one dimensional problem of flow through parallel layers of clothing and air. Body temperatures are calculated based on...prescribed work rates, ambient conditions and clothing properties. Sweat response and respiration rates are estimated based on empirical data to

Sarcolemmal localisation of Na+/H+ exchange and Na+–HCO3− co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes

PubMed Central

Garciarena, Carolina D; Ma, Yu-ling; Swietach, Pawel; Huc, Laurence; Vaughan-Jones, Richard D

2013-01-01

Membrane acid extrusion by Na+/H+ exchange (NHE1) and Na+–HCO3− co-transport (NBC) is essential for maintaining a low cytoplasmic [H+] (∼60 nm, equivalent to an intracellular pH (pHi) of 7.2). This protects myocardial function from the high chemical reactivity of H+ ions, universal end-products of metabolism. We show here that, in rat ventricular myocytes, fluorescent antibodies map the NBC isoforms NBCe1 and NBCn1 to lateral sarcolemma, intercalated discs and transverse tubules (t-tubules), while NHE1 is absent from t-tubules. This unexpected difference matches functional measurements of pHi regulation (using AM-loaded SNARF-1, a pH fluorophore). Thus, myocyte detubulation (by transient exposure to 1.5 m formamide) reduces global acid extrusion on NBC by 40%, without affecting NHE1. Similarly, confocal pHi imaging reveals that NBC stimulation induces spatially uniform pHi recovery from acidosis, whereas NHE1 stimulation induces pHi non-uniformity during recovery (of ∼0.1 units, for 2–3 min), particularly at the ends of the cell where intercalated discs are commonly located, and where NHE1 immunostaining is prominent. Mathematical modelling shows that this induction of local pHi microdomains is favoured by low cytoplasmic H+ mobility and long H+ diffusion distances, particularly to surface NHE1 transporters mediating high membrane flux. Our results provide the first evidence for a spatial localisation of [H+]i regulation in ventricular myocytes, suggesting that, by guarding pHi, NHE1 preferentially protects gap junctional communication at intercalated discs, while NBC locally protects t-tubular excitation–contraction coupling. PMID:23420656

Operation "Frontal Lobe" versus the "Living Room Toy": The Battle over Program Control in Early Television.

ERIC Educational Resources Information Center

Boddy, William

The development of the television industry in the United States as it emerged in the 1950s is mirrored by tracing the policies and actions of NBC (the National Broadcasting Company) during this period. As the leading radio network and as a subsidiary of RCA (the Radio Corporation of America), NBC was in a uniquely powerful position to direct the…

The Impact of Accelerated Promotion Rates on Drill Sergeant Performance

DTIC Science & Technology

2011-01-01

land navigation, communication (voice/visual), NBC protection). I have good knowledge of most Warrior tasks; I have sufficient skills to handle...but seldom reach out on my own initiative. I communicate and work well with others regardless of background; I encourage attitudes of tolerance and...most of the Warrior tasks (e.g., land navigation, communication (voice/visual), NBC protection). I have good knowledge of most Warrior tasks; I

Enhanced electron-phonon coupling near the lattice instability of superconducting NbC1-xNx from density-functional calculations

NASA Astrophysics Data System (ADS)

Blackburn, Simon; Côté, Michel; Louie, Steven G.; Cohen, Marvin L.

2011-09-01

Using density-functional theory within the local-density approximation, we study the electron-phonon coupling in NbC1-xNx and NbN crystals in the rocksalt structure. The Fermi surface of these systems exhibits important nesting. The associated Kohn anomaly greatly increases the electron-phonon coupling and induces a structural instability when the electronic density of states reaches a critical value. Our results reproduce the observed rise in Tc from 11.2 to 17.3 K as the nitrogen doping is increased in NbC1-xNx. To further understand the contribution of the structural instability to the rise of the superconducting temperature, we develop a model for the Eliashberg spectral function in which the effect of the unstable phonons is set apart. We show that this model together with the McMillan formula can reproduce the increase of Tc near the structural phase transition.

An Annotated Bibliography of MANPRINT-Related Assessments and Evaluations Conducted by the U.S. Army, 2nd Edition: 1953 to 2009. Volume 1- Index

DTIC Science & Technology

2010-02-01

System (ACABA) MA 1973 Armored Vest M1955 Body Armor- Armored Vest M1955 USMC M1955 Armored Vest and the Proposed Titanium Nylon Improved... Laser - MILES Multiple Integrated Laser Engagement System in an Operational Environment (MILES) MA 1980 SAW M249 Rifle- 5.56mm- Machine Gun- SAW M249...Weapon System MA 1993 MCF MCF Modular Causeway Ferry (MCF) MA 1993 MDS NBC- Decon- MDS Modular Decontamination System (MDS) MA 1993 MELIOS Laser

Factors That Affect Large Subunit Ribosomal DNA Amplicon Sequencing Studies of Fungal Communities: Classification Method, Primer Choice, and Error

PubMed Central

Porter, Teresita M.; Golding, G. Brian

2012-01-01

Nuclear large subunit ribosomal DNA is widely used in fungal phylogenetics and to an increasing extent also amplicon-based environmental sequencing. The relatively short reads produced by next-generation sequencing, however, makes primer choice and sequence error important variables for obtaining accurate taxonomic classifications. In this simulation study we tested the performance of three classification methods: 1) a similarity-based method (BLAST + Metagenomic Analyzer, MEGAN); 2) a composition-based method (Ribosomal Database Project naïve Bayesian classifier, NBC); and, 3) a phylogeny-based method (Statistical Assignment Package, SAP). We also tested the effects of sequence length, primer choice, and sequence error on classification accuracy and perceived community composition. Using a leave-one-out cross validation approach, results for classifications to the genus rank were as follows: BLAST + MEGAN had the lowest error rate and was particularly robust to sequence error; SAP accuracy was highest when long LSU query sequences were classified; and, NBC runs significantly faster than the other tested methods. All methods performed poorly with the shortest 50–100 bp sequences. Increasing simulated sequence error reduced classification accuracy. Community shifts were detected due to sequence error and primer selection even though there was no change in the underlying community composition. Short read datasets from individual primers, as well as pooled datasets, appear to only approximate the true community composition. We hope this work informs investigators of some of the factors that affect the quality and interpretation of their environmental gene surveys. PMID:22558215

Preparation and Analysis of Samples for the Third Round Robin Verification Exercise

DTIC Science & Technology

1992-07-01

Hooge 34 Lid instituuts Advies Raad PML Prof. dr. U.A. Th. Brinkman 35 Directeur van het Medisch Biologisch Laboratorium TNO Proft dr. W.R.F. Notten 36...1991 werd uitgevoerd, heeft het Prins Maurits Laboratorium TNO de monsters aangemaakt die bestonden uit rubber, verf en beton. Deze materialen, die...Maurits Laboratorium TNO Chemische Research Prof. dr. G. Dijksrra 10 HBur. NBC-DMKIJOMATIKIO In. A.A.M. Slagveer 11 Lid van de Contact Cominissie NBC

IJME Fifth National Bioethics Conference: a summary report.

PubMed

Saligram, Prasanna; Kurpad, Sunita Simon; Narayan, Thelma

2015-01-01

The Fifth National Bioethics Conference (NBC) was co-hosted by St John's National Academy of Health Sciences (SJNAHS), Bangalore; Society for Community Health Research Awareness and Action (SOCHARA), Bangalore; and Forum for Medical Ethics Society (FMES), Mumbai, which publishes the Indian Journal of Medical Ethics (IJME). The conference was held at the St John's campus, Bangalore from December 11 to 13, 2014. The theme of the Fifth NBC was "Integrity in medical care, public health, and health research".

Nanobiocatalyst advancements and bioprocessing applications

PubMed Central

Misson, Mailin; Zhang, Hu; Jin, Bo

2015-01-01

The nanobiocatalyst (NBC) is an emerging innovation that synergistically integrates advanced nanotechnology with biotechnology and promises exciting advantages for improving enzyme activity, stability, capability and engineering performances in bioprocessing applications. NBCs are fabricated by immobilizing enzymes with functional nanomaterials as enzyme carriers or containers. In this paper, we review the recent developments of novel nanocarriers/nanocontainers with advanced hierarchical porous structures for retaining enzymes, such as nanofibres (NFs), mesoporous nanocarriers and nanocages. Strategies for immobilizing enzymes onto nanocarriers made from polymers, silicas, carbons and metals by physical adsorption, covalent binding, cross-linking or specific ligand spacers are discussed. The resulting NBCs are critically evaluated in terms of their bioprocessing performances. Excellent performances are demonstrated through enhanced NBC catalytic activity and stability due to conformational changes upon immobilization and localized nanoenvironments, and NBC reutilization by assembling magnetic nanoparticles into NBCs to defray the high operational costs associated with enzyme production and nanocarrier synthesis. We also highlight several challenges associated with the NBC-driven bioprocess applications, including the maturation of large-scale nanocarrier synthesis, design and development of bioreactors to accommodate NBCs, and long-term operations of NBCs. We suggest these challenges are to be addressed through joint collaboration of chemists, engineers and material scientists. Finally, we have demonstrated the great potential of NBCs in manufacturing bioprocesses in the near future through successful laboratory trials of NBCs in carbohydrate hydrolysis, biofuel production and biotransformation. PMID:25392397

Effects of processing and prolonged high temperature exposure on the microstructure of Nb-1Zr-C sheet

NASA Technical Reports Server (NTRS)

Uz, Mehmet; Titran, R. H.

1993-01-01

High temperature stability of the microstructure of Nb-1Zr sheet containing 0.1 and 0.06 wt. percent C was studied as affected by processing and prolonged 1350 K exposure with and without applied stress. Sheets were fabricated by cold rolling bars that were single-, double-, or triple-extruded at 1900 K. Creep samples were double-annealed (1 h at 1755 K + 2 h at 1475 K) prior to testing at 1350 K and 10,000 - 34,500 h. The microstructures of the as-cast, extruded, rolled, DA, and crept samples were characterized using various metallographic and analytical methods. The precipitates were rather coarse Nb2C initially, but transformed to finer (less than or equal to 1 micron) carbides of (Zr, Nb)C with each subsequent high temperature process. The grain size, and the relative amount and morphology of (Zr, Nb)C were found to be affected by the number of extrusions and to some extent by C-content. However, the microstructures of all the crept samples were similar with (Zr, Nb)C distributed throughout the matrix indicating that prolonged exposure to 1350 K gave rise to complete transformation of Nb2C to (Zr, Nb)C regardless of the processing history. These and other observations are presented with the emphasis on the correlation between processing, microstructure, and creep properties.

Ice cooling vest on tolerance for exercise under uncompensable heat stress.

PubMed

Kenny, Glen P; Schissler, Andrew R; Stapleton, Jill; Piamonte, Matthew; Binder, Konrad; Lynn, Aaron; Lan, Christopher Q; Hardcastle, Stephen G

2011-08-01

This study was conducted to evaluate the effectiveness of a commercial, personal ice cooling vest on tolerance for exercise in hot (35°C), wet (65% relative humidity) conditions with a nuclear biological chemical suit (NBC). On three separate occasions, 10 male volunteers walked on a treadmill at 3 miles per hour and 2% incline while (a) seminude (denoted CON), (b) dressed with a nuclear, biological, chemical (NBC) suit with an ice vest (V) worn under the suit (denoted NBCwV); or (c) dressed with an NBC suit but without an ice vest (V) (denoted NBCwoV). Participants exercised for 120 min or until volitional fatigue, or esophageal temperature reached 39.5°C. Esophageal temperature (T(es)), heart rate (HR), thermal sensation, and ratings of perceived exertion were measured. Exercise time was significantly greater in CON compared with both NBCwoV and NBCwV (p < 0.05), whereas T(es), thermal sensation, heart rate, and rate of perceived exertion were lower (p < 0.05). Wearing the ice vest increased exercise time (NBCwoV, 103.6 ± 7.0 min; NBCwV, 115.9 ± 4.1 min) and reduced the level of thermal strain, as evidenced by a lower T(es) at end-exercise (NBCwoV, 39.03 ± 0.13°C; NBCwV, 38.74 ± 0.13°C) and reduced thermal sensation (NBCwoV, 6.4 ± 0.4; NBCwV, 4.8 ± 0.6). This was paralleled by a decrease in rate of perceived exertion (NBCwoV, 14.7 ± 1.6; NBCwV, 12.4 ± 1.6) (p < 0.05) and heat rate (NBCwoV, 169 ± 6; NBCwV, 159 ± 7) (p < 0.05). We show that a commercially available cooling vest can significantly reduce the level of thermal strain during work performed in hot environments.

Investigation on the relationship between NbC and wear-resistance of Fe matrix composite coatings with different C contents

NASA Astrophysics Data System (ADS)

Zhao, Changchun; Zhou, Yefei; Xing, Xiaolei; Liu, Sha; Ren, Xuejun; Yang, Qingxiang

2018-05-01

The wear resistance of Fe-based composite coating is significantly related with the character of carbides and matrix, which could be strongly affected by C content in it. In this work, the Fe-based composite coatings with different C contents were prepared. The microstructure and phase structure of the coatings were analyzed by scanning electron microscope (SEM) equipped with an energy-dispersive spectroscopy (EDS) and X-ray diffractometer (XRD). The hardness and wear resistance of the coatings were determined. Then the hardness and brittleness of carbon poor niobium carbides were calculated by first principles calculation. The results show that, the phase structures of the coatings are mainly composed of NbC, γ phase (retained austenite) and α phase (martensite). With the increase of C content, the retained austenite appears and C content of martensite is increased. The hardness of the coatings are increased from HRC 22 to HRC 59. The distribution and morphology of NbC are changed with the increase of C content. The NbC precipitated in reticular grain boundary can be observed when C content is 0.4 wt.% C (C-1). NbC turn into granular and small rod morphology when C content increases to 0.8 wt.% C (C-2). The cracks and defects cannot been found on the surface of the coating when C content is 1.2 wt.% C(C-3), whose hardness is HRC 58 and wear loss is 0.27 g/N cm2 in 8 h. The flaky M7C3 carbide precipitates on the coating when C content is 1.4 wt.% C(C-4), which weaken the wear resistance of the matrix. Compared with the hardfacing coatings with different C contents, the C-3 coating processes higher hardness and wear resistance.

Examining the Religious Strands of Islamic Terrorists to Enhance U.S. Security

DTIC Science & Technology

2012-03-01

faith with the state; rather, there is a clear separation of church and state. Many times in discussions at social events or even in academic settings...examination of this particular tenet of Islam, one recent such example of sharia law that surfaced on 30 January 2012 was reported by NBC Nightly News ...his conclusion of the report on the murders in Ontario, Canada on NBC Nightly News , Kevin Tibbles stated that there really is no accurate number of

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samsonov, G. V.; Vitryanyuk, V. K.; Voronkin, M. A.

Physicomechanical properties of the hard alloy TiC -Ni--Mo (with content 3. 5, 10, and 25 mol.% relative to TiC) were studied as affected by its carbide phase alloying with niobium carbide. It is shown that an increase in the NbC content favors a rise in the bending strength to 132 kg/mm/sup 2/ and impact strength at practically unchanged hardness (91 HR.4), which is explained by some rise in the grain plasticity of the solid phase presenting the complex carbide TiC -NbC.

Clinical ethics and the role of clinical ethics committees: proposals for a revival. Commentary.

PubMed

Petrini, Carlo; Ricciardi, Walter

2017-01-01

The issue addressed in the paper published by the Italian National Bioethics Committee (NBC) entitled "Clinical ethics committees", is highly significant for many reasons. One of these is the fact that the ethics committees charged with assessing clinical trials have so much responsibility and such a heavy work-load that they have little time available for other tasks such as engaging directly with patients "at the bedside", as a result of which the role of committees responsible for assessing clinical cases is especially important. According to the NBC, the opinions of clinical ethics committees should be formulated jointly and are non-binding. The NBC offers practical proposals not only for the Italian context. While the Italian National Institute of Health (Istituto Superiore di Sanità - ISS) is not involved directly in treating patients, its role in providing guidance is crucial to the national health service and it has always paid special attention to these issues.

Bioethics and the Italian National Bioethics Committee: historical highlights.

PubMed

Conti, A A

2016-01-01

Though the term "bioethics" was coined in 1970-1, it was immediately after World War II that there emerged the idea that the voluntary consent of human beings was absolutely mandatory for medical interventions to be ethically acceptable. The 1964 Declaration of Helsinki asserted that only an explicit consent could morally and ethically justify research on human beings. In the 1978 "Encyclopedia of Bioethics", the US author Warren T. Reich defined bioethics as the systematic study of human behaviour in the fields of health care and life sciences, and carefully differentiated the epistemological profile of bioethics from that of traditional medical ethics deriving from the Hippocratic Oath. An institutional milestone in the Italian evolution of bioethical knowledge and competence was the foundation of the Italian National Bioethics Committee (NBC), established in 1990. The NBC, which answers to the Council of Ministers, provides methodological support to the Italian Government in the field of bioethical issues, elaborating legislative acts and also furnishing information and consultation for other bodies and associations and for the general public. The activity of the NBC is clearly discernible in its free and user-friendly website. Today, the Internet is often the first repository where individuals and patients look for bioethical information. Given that the quality of this information is extremely variable and not infrequently unreliable, initiatives such as that of the above mentioned NBC website are particularly useful and precious both for health care operators and the entire community.

Television commercial violence during nonviolent programming: the 1998 major league baseball playoffs.

PubMed

Anderson, C R

2000-10-01

To identify the frequency of violent commercials during the major league baseball playoffs in 1998 and to compare it with the 1996 playoffs. All 4 World Series games televised on the Fox Television Network (Fox), all 6 National League Championship Series (NLCS) televised by Fox, and 5 of 6 American League Championship Series (ALCS) playoff games televised by the National Broadcasting Company (NBC) were videotaped in October 1998. The results were compared with a similar study that analyzed the 1996 playoffs. Forty-four commercials (11.0 per game) that included violent interactions were noted during the World Series, 53 violent commercials (8.8 per game) during the NLCS, and 40 (8.0 per game) during the ALCS for a total of 137. Of these 137 violent commercials, 78 contained at least 1 violent act, 126 contained at least 1 violent threat, and 12 contained evidence of at least 1 violent consequence. One hundred five of the 137 violent commercials (76.6%) were television promotions and 23 (16.8%) were for big-screen movie promotions. Twenty-three of 35 big-screen movie promotions (65.7%) were violent. Ten of the 137 violent commercials (7.3%) contained obvious blood, of which 9 were televised by NBC. There were, however, an additional 20 commercials televised by Fox that contained visible blood if the videotape was slowed or paused. Sixty-three of the 137 violent commercials (46.0%) used fire and explosions, of which 53 were televised by Fox and 10 by NBC. Guns were involved in 86 of 137 violent commercials (62.8%), with Fox accounting for 64 (6.4 per game) and NBC accounting for 22 (4.4 per game). Knives were used in 1 violent commercial on both Fox and NBC. Comparisons that can be made to 1996 include the following: 1) violent commercials during the World Series (both televised by Fox) increased from 10.1 to 11.0 per game; and 2) violent commercials during the ALCS (both televised by NBC) increased from 6.0 to 8.0 per game. Commercials during the 1998 major league playoffs were similar in violent content, compared with 1996. The violent commercials continue to consist primarily of promotions for television programs and big-screen movies. It continues to be counterintuitive to find such commercials in family-oriented programming and makes it difficult for parents to avoid exposing their children to this form of violence.

Effects of latitudinal changes in the oxygen minimum zone of the northeast Pacific on the distribution of bathyal benthic decapod crustaceans

NASA Astrophysics Data System (ADS)

Papiol, Vanesa; Hendrickx, Michel E.; Serrano, David

2017-03-01

The presence of an Oxygen Minimum Zone (OMZ) is one of the major characteristics of the eastern Pacific. The OMZ changes strongly adjacent to Mexico in its thickness and intensity. The ecological impacts of those changes were studied by examining the community structures of bathyal benthic and bentho-pelagic decapod crustaceans, and their oceanographic contexts, on the Mexican Pacific slope along a wide latitudinal range (16-32°N). Decapod crustaceans were collected with a benthic sledge from 48 stations between 865 and 2165 m in three main areas: offshore of northern Baja California (NBC), off southern Baja California (SBC) and in the southern Mexican Pacific (SMP). Physical-chemical parameters were measured in the water column, and sediment composition was analyzed for each station. The narrowing and weakening of the OMZ north of ca. 26°N was confirmed. Water with dissolved oxygen <0.5 ml l-1 occupied a stratum of 1231 m in the SMP vs. only 664 m off NBC. The strongest changes coincided with a region of surface, subsurface and intermediate water mass transitions, where less saline waters from the north extended to depths of ca. 1000 m. Sand proportions were higher in sediments to the south, whereas silt dominated offshore of NBC. A strong latitudinal shift in decapod community composition and bathymetric distribution occurred from off SBC to off NBC, coinciding with changes in oceanographic conditions. The dominant genera of decapod crustaceans at slope depths were cognate to those dominating slope areas in other tropical and subtropical regions of the world. In the SMP and off SBC, large aggregations of organisms were observed at 900-1300 m, with a sharp decrease in abundance at greater depth. Off NBC, the density of organisms was intermediate at all depths. The combined effects of dissolved oxygen concentration and characteristics of water masses affected the distribution of organisms. The faunal patterns were also related with sediment grain size.

The microsporidium Nosema disstriae (Thomson 1959): Fine structure and phylogenetic position within the N. bombycis clade.

PubMed

Kyei-Poku, George; Sokolova, Yuliya Y

2017-02-01

A microsporidium Nosema disstriae (Thomson) is a parasite of the forest tent caterpillar Malacasoma disstria (Lepidoptera: Lasiocampidae), a notable defoliator of deciduous trees in North America. The goal of this paper was to demonstrate the ultrastructure of N. disstriae and to determine the position of this microsporidium within the N. bombycis clade (NBC) using comparative morphology and multiple molecular phylogenetic markers: RPB1, LSU-, ITS- and SSU-rDNA. As a part of this goal, the revision of the described members of the NBC has been performed. The ultrastructure of proliferating stages and spores of N. disstriae were similar to previously described Nosema spp. parasitizing lepidopteran species. Meronts produced tubular-like structures on their surfaces and exhibited a tight association with host mitochondria. All stages were diplokaryotic and developed without interfacial envelopes. Disporoblastic sporogony produced typical Nosema-type spores with 9-12 polar filament coils. A vesicle with immature spores was once recognized on sections, concordant with the previous record of octosporous sporogony in the N. disstriae life cycle. Rarely, spores with thinner envelopes and large posterior vacuoles were seen in the midgut. Tracheae were most heavily infected. Midgut, surrounding muscles, haemocytes and fat body also contained microsporidia. SSUrRNA-inferred phylogenies were consistent with previously published articles and did not resolve the relation within the NBC clade. The RPB1-inferred trees and concatenated RPB1 and LSU-ITS-SSUrDNA-based trees demonstrated clustering of N. disstriae with N. antheraeae as early divergent species within the NBC. Copyright © 2016 Elsevier Inc. All rights reserved.

Physiological tolerance to uncompensated heat stress in soldiers: effects of various types of body cooling systems.

PubMed

Jovanović, Dalibor; Karkalić, Radovan; Zeba, Snjezana; Pavlović, Miroslav; Radaković, Sonja S

2014-03-01

In military services, emergency situations when soldiers are exposed to a combination of nuclear, biological and chemical (NBC) contamination combined with heat stress, are frequent and complex. In these specific conditions, usage of personal body cooling systems may be effective in reducing heat stress. The present study was conducted in order to evaluate the efficiency of four various types of contemporary personal body cooling systems based on the "Phase Change Material" (PCM), and its effects on soldiers' subjective comfort and physiological performance during exertional heat stress in hot environments. Ten male soldiers were voluntarily subjected to exertional heat stress tests (EHSTs) consisted of walking on a treadmill (5.5 km/h) in hot conditions (40 degreesC) in climatic chamber, wearing NBC isolating impermeable protective suits. One of the tests was performed without any additional cooling solution (NOCOOL), and four tests were performed while using different types of cooling systems: three in a form of vests and one as underwear. Physiological strain was determined by the mean skin temperature (Tsk), tympanic temperature (Tty), and heart rate values (HR), while sweat rates (SwR) indicated changes in hydration status. In all the cases EHST induced physiological response manifested through increasing Tty, HR and SwR. Compared to NOCOOL tests, when using cooling vests, Tty and Tsk were significantly lower (on 35th min, for 0.44 +/- 0.03 and 0.49 +/- 0.05 degrees C, respectively; p < 0.05), as well as the average SwR (0.17 +/- 0.03 L/m2/h). When using underwear, the values of given parameters were not significantly different compared to NOCOOL tests. Using a body cooling system based on PCM in the form of vest under NBC protective clothes during physical activity in hot conditions, reduces sweating and alleviates heat stress manifested by increased core and skin temperatures and heart rate values. These effects directly improve heat tolerance, hydration state, decrease in the risk of heat illness, and extends the duration of soldiers' exposure to extreme conditions.

National environmental observing system to mitigate the effects of nuclear-biological-chemical (NBC) attacks: strategic and tactical

NASA Astrophysics Data System (ADS)

Fleming, Rex J.

2003-09-01

The challenge of obtaining an adequate environmental support system to help mitigate the effects of various terrorist generated plumes is articulated and a fiscally responsible solution is presented. A substantially improved national system of upper air data observing systems serves as a powerful information source prior to a terrorist event. A mobile tactical observing system for measuring the environment and for measuring the composition and intensity of the plume is implemented immediately following an event. Only proven and tested technologies are used. Program costs, benefits for the fight against terrorism, and multiple benefits to other aspects of the economy are summarized.

Genetic Differentiation of North-East Argentina Populations Based on 30 Binary X Chromosome Markers.

PubMed

Di Santo Meztler, Gabriela P; Del Palacio, Santiago; Esteban, María E; Armoa, Isaías; Argüelles, Carina F; Catanesi, Cecilia I

2018-01-01

Alu insertions, INDELs, and SNPs in the X chromosome can be useful not only for revealing relationships among populations but also for identification purposes. We present data of 10 Alu insertions, 5 INDELs, and 15 SNPs of X-chromosome from three Argentinian north-east cities in order to gain insight into the genetic diversity of the X chromosome within this region of the country. Data from 198 unrelated individuals belonging to Posadas, Corrientes, and Eldorado cities were genotyped for Ya5DP62, Yb8DP49, Ya5DP3, Ya5NBC37, Ya5DP77, Ya5NBC491, Ya5DP4, Ya5DP13, Yb8NBC634, and Yb8NBC102 Alu insertions, for MID193, MID1705, MID3754, MID3756 and MID1540 Indels and for rs6639398, rs5986751, rs5964206, rs9781645, rs2209420, rs1299087, rs318173, rs933315, rs1991961, rs4825889, rs1781116, rs1937193, rs1781104, rs149910, and rs652 SNPs. No deviations from Hardy-Weinberg equilibrium were observed for Posadas and Corrientes. However, Eldorado showed significant values, and it was found to have an internal substructuring with two groups of different origin, one showing higher similarity with European countries, and the other with more similarities to Posadas and Corrientes. F st pairwise genetic distances emerged for some markers among the studied populations and also between our data and those from other countries and continents. Of particular interest, Alu insertions demonstrated the most differences, and could be of use in ancestry studies for these populations, while INDELs and SNPs variation were informative for differentiation within the country.

CFTR/ENaC dependent regulation of membrane potential during human sperm capacitation is initiated by bicarbonate uptake through NBC.

PubMed

Puga Molina, Lis C; Pinto, Nicolas A; Torres, Nicolás I; Gonzalez-Cota, Ana L; Luque, Guillermina M; Balestrini, Paula A; Romarowski, Ana; Krapf, Dario; Santi, Celia M; Trevino, Claudia L; Darszon, Alberto; Buffone, Mariano G

2018-05-09

To fertilize an egg, sperm must reside in the female reproductive tract to undergo several maturational changes that are collectively referred to as capacitation. From a molecular point of view, the HCO3--dependent activation of the atypical soluble adenylyl cyclase (ADCY10) is one of the first events that occurs during capacitation and leads to the subsequent cAMP-dependent activation of protein kinase A (PKA). Capacitation is also accompanied by hyperpolarization of the sperm plasma membrane. We previously reported that PKA activation is necessary for CFTR (Cystic Fibrosis Transmembrane Conductance Regulator Channel) activity and for the modulation of membrane potential (Em). However, the main HCO3- transporters involved in the initial transport and the PKA-dependent Em changes are not well known nor characterized. Here, we analyzed how the activity of CFTR regulates Em during capacitation and examined its relationship with an electrogenic Na+/HCO3- cotransporter (NBC) and epithelial Na+ channels (ENaCs). We observed that inhibition of both CFTR and NBC decreased HCO3- influx, resulting in lower PKA activity, and that events downstream the cAMP-activation of PKA are essential for the regulation of Em. Addition of a permeable cAMP analog partially rescued the inhibitory effects caused by these inhibitors. HCO3-  also produced a rapid membrane hyperpolarization mediated by ENaC channels, which contribute to the regulation of Em during capacitation. Altogether, we demonstrate for the first time, that NBC cotransporters and ENaC channels are essential in the CFTR-dependent activation of the cAMP/PKA signaling pathway and Em regulation during human sperm capacitation. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.

[Analysis of ethnogeographic groups of Kazakhs based on nuclear genome DNA polymorphism].

PubMed

Salimova, A Z; Kutuev, I A; Khusainova, R I; Akhmetova, V L; Sviatova, G S; Berezina, G M; Khusnutdinova, E K

2005-07-01

Eight nuclear DNA loci, including six Alu insertions (ACE, APOA1, PV92, TPA25, Ya5NBC27, and Ya5NBC148), 32-bp deletion in the CCR5 gene, and VNTR locus at the eNOS gene, were examined in three ethnogeographic groups of Kazakhs (342 individuals). The individuals examined lived in southeastern, central, and southwestern regions of Kazakhstan, and according to their tribal attribution, belonged to the Senior, Middle, and Junior Zhuzes. The Alu insertions appeared to be polymorphic in all populations examined: the insertion frequency varied from 0.264 in the populations of the Senior and Middle Zhuzes at the Ya5NBC27 and Ya5NBC148 loci, to 0.827 in Kazakhs of the Middle Zhuz at the APOA1 locus. In Kazakh groups examined only two alleles of the eNOS VNTR locus were detected with the number of repeats constituting four (A) and five (B) copies. The highest frequency of A allele was found in Kazakhs from the Junior Zhuz (0.113), while the highest frequency of B allele was detected in population of the Senior Zhuz (0.893). The frequency of the 32-bp deletion in the chemokine receptor CCR5 gene varied from 0.027 in the Junior Zhuz to 0.045 in the Senior Zhuz. Kazakhs showed high genetic diversity (Hex = 0.376). In general, in three ethnogeographic groups of Kazakhs, the coefficient of gene differentiation (G(ST)) over eight diallelic markers of nuclear genome constituted 1.1%. The differences in the Alu insertions made the highest contribution to the among-population diversity (G(ST) = 1.2%).

Contribution of precipitate on migrated grain boundaries to ductility-dip cracking in Alloy 625 weld joints

NASA Astrophysics Data System (ADS)

Lee, Dong Jin; Kim, Youn Soo; Shin, Yong Taek; Jeon, Eon Chan; Lee, Sang Hwa; Lee, Hyo-Jong; Lee, Sung Keun; Lee, Jun Hee; Lee, Hae Woo

2010-10-01

We investigated the crack properties in Alloy 625 weld metals and their characteristics using experimentally designed filler wires fabricated by varying the niobium and manganese contents in the flux with the shield metal arc welding (SMAW) process. The fast diffusivity of niobium on the migrated grain boundary (MGB) under strong restraint tensile stress, which was induced by the hardened matrix in weld metal containing high niobium and manganese, accelerated the growth of niobium carbide (NbC) in multipass deposits. Coalescence of microvoids along with incoherent NbC and further propagation induced ductility-dip cracking (DDC) on MGB.

Co-precipitated and collocated carbides and Cu-rich precipitates in a Fe-Cu steel characterized by atom-probe tomography.

PubMed

Kolli, R Prakash; Seidman, David N

2014-12-01

The composition of co-precipitated and collocated NbC carbide precipitates, Fe3C iron carbide (cementite), and Cu-rich precipitates are studied experimentally by atom-probe tomography (APT). The Cu-rich precipitates located at a grain boundary (GB) are also studied. The APT results for the carbides are supplemented with computational thermodynamics predictions of composition at thermodynamic equilibrium. Two types of NbC carbide precipitates are distinguished based on their stoichiometric ratio and size. The Cu-rich precipitates at the periphery of the iron carbide and at the GB are larger than those distributed in the α-Fe (body-centered cubic) matrix, which is attributed to short-circuit diffusion of Cu along the GB. Manganese segregation is not observed at the heterophase interfaces of the Cu-rich precipitates that are located at the periphery of the iron carbide or at the GB, which is unlike those located at the edge of the NbC carbide precipitates or distributed in the α-Fe matrix. This suggests the presence of two populations of NiAl-type (B2 structure) phases at the heterophase interfaces in multicomponent Fe-Cu steels.

Niobium Carbide-Reinforced Al Matrix Composites Produced by High-Energy Ball Milling

NASA Astrophysics Data System (ADS)

Travessa, Dilermando Nagle; Silva, Marina Judice; Cardoso, Kátia Regina

2017-06-01

Aluminum and its alloys are key materials for the transportation industry as they contribute to the development of lightweight structures. The dispersion of hard ceramic particles in the Al soft matrix can lead to a substantial strengthening effect, resulting in composite materials exhibiting interesting mechanical properties and inspiring their technological use in sectors like the automotive and aerospace industries. Powder metallurgy techniques are attractive to design metal matrix composites, achieving a homogeneous distribution of the reinforcement into the metal matrix. In this work, pure aluminum has been reinforced with particles of niobium carbide (NbC), an extremely hard and stable refractory ceramic. Its use as a reinforcing phase in metal matrix composites has not been deeply explored. Composite powders produced after different milling times, with 10 and 20 vol pct of NbC were produced by high-energy ball milling and characterized by scanning electron microscopy and by X-ray diffraction to establish a relationship between the milling time and size, morphology, and distribution of the particles in the composite powder. Subsequently, an Al/10 pct NbC composite powder was hot extruded into cylindrical bars. The strength of the obtained composite bars is comparable to the commercial high-strength, aeronautical-grade aluminum alloys.

The Nutrient Balance Concept: A New Quality Metric for Composite Meals and Diets

PubMed Central

Fern, Edward B; Watzke, Heribert; Barclay, Denis V.; Roulin, Anne; Drewnowski, Adam

2015-01-01

Background Combinations of foods that provide suitable levels of nutrients and energy are required for optimum health. Currently, however, it is difficult to define numerically what are ‘suitable levels’. Objective To develop new metrics based on energy considerations—the Nutrient Balance Concept (NBC)—for assessing overall nutrition quality when combining foods and meals. Method The NBC was developed using the USDA Food Composition Database (Release 27) and illustrated with their MyPlate 7-day sample menus for a 2000 calorie food pattern. The NBC concept is centered on three specific metrics for a given food, meal or diet—a Qualifying Index (QI), a Disqualifying Index (DI) and a Nutrient Balance (NB). The QI and DI were determined, respectively, from the content of 27 essential nutrients and 6 nutrients associated with negative health outcomes. The third metric, the Nutrient Balance (NB), was derived from the Qualifying Index (QI) and provided key information on the relative content of qualifying nutrients in the food. Because the Qualifying and Disqualifying Indices (QI and DI) were standardized to energy content, both become constants for a given food/meal/diet and a particular consumer age group, making it possible to develop algorithms for predicting nutrition quality when combining different foods. Results Combining different foods into composite meals and daily diets led to improved nutrition quality as seen by QI values closer to unity (indicating nutrient density was better equilibrated with energy density), DI values below 1.0 (denoting an acceptable level of consumption of disqualifying nutrients) and increased NB values (signifying complementarity of foods and better provision of qualifying nutrients). Conclusion The Nutrient Balance Concept (NBC) represents a new approach to nutrient profiling and the first step in the progression from the nutrient evaluation of individual foods to that of multiple foods in the context of meals and total diets. PMID:26176770

Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss.

PubMed

Preuss, H G; Bagchi, D; Bagchi, M; Rao, C V S; Dey, D K; Satyanarayana, S

2004-05-01

The efficacy of optimal doses of highly bioavailable (-)-hydroxycitric acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. HCA-SX has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has demonstrated its ability to maintain healthy insulin levels, while GSE has been shown to regulate weight loss and blood sugar levels. A randomized, double-blind, placebo-controlled human study was conducted in Elluru, India for 8 weeks in 60 moderately obese subjects (ages 21-50, BMI >26 kg/m(2)). Subjects were randomly divided into three groups. Group A was administered HCA-SX 4667 mg, group B was administered a combination of HCA-SX 4667 mg, NBC 4 mg and GSE 400 mg, while group C was given placebo daily in three equally divided doses 30-60 min before meals. All subjects received a 2000 kcal diet/day and participated in supervised walking. At the end of 8 weeks, body weight and BMI decreased by 5-6% in both groups A and B. Food intake, total cholesterol, low-density lipoproteins, triglycerides and serum leptin levels were significantly reduced in both groups, while high-density lipoprotein levels and excretion of urinary fat metabolites increased in both groups. A marginal or non-significant effect was observed in all parameters in group C. The present study shows that optimal doses of HCA-SX and, to a greater degree, the combination of HCA-SX, NBC and GSE can serve as an effective and safe weight-loss formula that can facilitate a reduction in excess body weight and BMI, while promoting healthy blood lipid levels.

Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.

PubMed

Reiners, Jan; van Wijk, Erwin; Märker, Tina; Zimmermann, Ulrike; Jürgens, Karin; te Brinke, Heleen; Overlack, Nora; Roepman, Ronald; Knipper, Marlies; Kremer, Hannie; Wolfrum, Uwe

2005-12-15

Usher syndrome (USH) is the most frequent cause of combined deaf-blindness in man. USH is clinically and genetically heterogeneous with at least 11 chromosomal loci assigned to the three USH types (USH1A-G, USH2A-C, USH3A). Although the different USH types exhibit almost the same phenotype in human, the identified USH genes encode for proteins which belong to very different protein classes and families. We and others recently reported that the scaffold protein harmonin (USH1C-gene product) integrates all identified USH1 molecules in a USH1-protein network. Here, we investigated the relationship between the USH2 molecules and this USH1-protein network. We show a molecular interaction between the scaffold protein harmonin (USH1C) and the USH2A protein, VLGR1 (USH2C) and the candidate for USH2B, NBC3. We pinpoint these interactions to interactions between the PDZ1 domain of harmonin and the PDZ-binding motifs at the C-termini of the USH2 proteins and NBC3. We demonstrate that USH2A, VLGR1 and NBC3 are co-expressed with the USH1-protein harmonin in the synaptic terminals of both retinal photoreceptors and inner ear hair cells. In hair cells, these USH proteins are also localized in the signal uptaking stereocilia. Our data indicate that the USH2 proteins and NBC3 are further partners in the supramolecular USH-protein network in the retina and inner ear which shed new light on the function of USH2 proteins and the entire USH-protein network. These findings provide first evidence for a molecular linkage between the pathophysiology in USH1 and USH2. The organization of USH molecules in a mutual 'interactome' related to the disease can explain the common phenotype in USH.

Research and Project Activities in Astrophysics

NASA Technical Reports Server (NTRS)

Harnden, F. Rick, Jr.; Kaluzienski, Louis J. (Technical Monitor)

2002-01-01

In collaboration with G Micela, S. Sciortino, and others at the Osservatorio Astronomico di Palermo G. S. Valens, we conducted studies of X-ray emission from normal stars, primarily via observations of several open star clusters and star forming regions (viz. the Pleiades, NBC 2516, NBC 2264, and the Orion Nebula Cluster). Our work was based on combined data from several X-ray observatories, Einstein, ROSAT, XMM-Newton and Chandra, as well as ground-based optical and radio data. Preliminary results were presented at several meetings: HEAD/AAS, November, 1997 a 195th AAS Meeting, January 2000 a Three Islands Conference, April 2000 a X-ray Astronomy 2000, September 2000 a 197th AAS Meeting, January 2001 Two Years of Science with Chandra, September 2001

Applying the health belief model to examine news coverage regarding steroids in sports by ABC, CBS, and NBC between March 1990 and May 2008.

PubMed

Quick, Brian L

2010-04-01

The investigation described here examined ABC, CBS, and NBC news coverage of steroids in sports between March 1990 and May 2008. Employing a framing analysis guided by the health belief model (HBM), coverage of the barriers and benefits of using steroids is reported. Overall, the trend by these three news affiliates was to emphasize the illegality of using steroids, whereas considerably less coverage was devoted to the health costs, in terms of both severity and susceptibility, of using steroids. Furthermore, of the health costs reported, the specific consequences of steroid use varied considerably. The results are reported across four timeframes: 1990-2008, 1990-1996, 1997-2002, and 2003-2008.

Functional Role of Tyr12 in the Catalytic Activity of Novel Zeta-like Glutathione S-transferase from Acidovorax sp. KKS102.

PubMed

Shehu, Dayyabu; Alias, Zazali

2018-05-19

Glutathione S-transferases (GSTs) are a family of enzymes that function in the detoxification of variety of electrophilic substrates. In the present work, we report a novel zeta-like GST (designated as KKSG9) from the biphenyl/polychlorobiphenyl degrading organism Acidovorax sp. KKS102. KKSG9 possessed low sequence similarity but similar biochemical properties to zeta class GSTs. Functional analysis showed that the enzyme exhibits wider substrate specificity compared to most zeta class GSTs by reacting with 1-chloro-2,4-dinitrobenzene (CDNB), p-nitrobenzyl chloride (NBC), ethacrynic acid (EA), hydrogen peroxide, and cumene hydroperoxide. The enzyme also displayed dehalogenation function against dichloroacetate, permethrin, and dieldrin. The functional role of Tyr12 was also investigated by site-directed mutagenesis. The mutant (Y12C) displayed low catalytic activity and dehalogenation function against all the substrates when compared with the wild type. Kinetic analysis using NBC and GSH as substrates showed that the mutant (Y12C) displayed a higher affinity for NBC when compared with the wild type, however, no significant change in GSH affinity was observed. These findings suggest that the presence of tyrosine residue in the motif might represent an evolutionary trend toward improving the catalytic activity of the enzyme. The enzyme as well could be useful in the bioremediation of various types of organochlorine pollutants.

Vapor-rich Hydrothermal Fluid Migration Within Pumiceous Sediment in the Iheya North Knoll, Okinawa Trough

NASA Astrophysics Data System (ADS)

Ishibashi, J.; Suzuki, R.; Hamasaki, H.; Yamanaka, T.; Chiba, H.; Tsunogai, U.; Ijiri, A.; Nakagawa, S.; Nunoura, T.; Takai, K.; Kinoshita, M.; Ashi, J.

2007-12-01

The newly developed ROV NSS (Navigable Sampling System) enabled pin-point piston core sampling from the active hydrothermal field. In the Iheya North hydrothermal field in the mid-Okinawa Trough (27°47.5'N, 126°53.8'E, depth = 1000m), animal colonies are observed not only around the central mound structure (named as NBC) which discharges vigrously high temperature (T=311°C) clear fluid, but also as Calyptogena colony at 200m east from the NBC mound and as tube-worm colony at 250m southeast from the NBC mound. During Leg 3 of KY05-14 cruise (R/V Kaiyo of JAMSTEC) in Jan. 2005, fourn piston cores were successfully recovered with length from 65cm to 250cm. Surface sediments from the Calyptogena colony and the tube-worm colony were revealed as mainly composed of pumiceous sediment. Pore fluids from the Calyptogena Field showed unusual chemistry characterized as very low salinity (Cl=420mM), low Mg concentration, significantly lower Na/Cl ratio than seawater and high methane concentration, which suggests contribution of a vapor-rich hydrothermal component migrating within the pumice layer from the activity center. Moreover, decrease of SO4 accompanied by increase of alkalinity is notable even less than one meter depth below the seafloor. In situ sulfate reduction in the surface sediment caused by entrainment of the hydrothermal component would be a source of hydrogen sulfide that supports Calyptogena colony.

Secretagogue stimulation enhances NBCe1 (electrogenic Na(+)/HCO(3)(-) cotransporter) surface expression in murine colonic crypts.

PubMed

Yu, Haoyang; Riederer, Brigitte; Stieger, Nicole; Boron, Walter F; Shull, Gary E; Manns, Michael P; Seidler, Ursula E; Bachmann, Oliver

2009-12-01

A Na(+)/HCO(3)(-) cotransporter (NBC) is located in the basolateral membrane of the gastrointestinal epithelium, where it imports HCO(3)(-) during stimulated anion secretion. Having previously demonstrated secretagogue activation of NBC in murine colonic crypts, we now asked whether vesicle traffic and exocytosis are involved in this process. Electrogenic NBCe1-B was expressed at significantly higher levels than electroneutral NBCn1 in colonic crypts as determined by QRT-PCR. In cell surface biotinylation experiments, a time-dependent increase in biotinylated NBCe1 was observed, which occurred with a peak of +54.8% after 20 min with forskolin (P < 0.05) and more rapidly with a peak of +59.8% after 10 min with carbachol (P < 0.05) and which corresponded well with the time course of secretagogue-stimulated colonic bicarbonate secretion in Ussing chamber experiments. Accordingly, in isolated colonic crypts pretreated with forskolin and carbachol for 10 min, respectively, and subjected to immunohistochemistry, the NBCe1 signal showed a markedly stronger colocalization with the E-cadherin signal, which was used as a membrane marker, compared with the untreated control. Cytochalasin D did not change the observed increase in membrane abundance, whereas colchicine alone enhanced NBCe1 membrane expression without an additional increase after carbachol or forskolin, and LY294002 had a marked inhibitory effect. Taken together, our results demonstrate a secretagogue-induced increase of NBCe1 membrane expression. Vesicle traffic and exocytosis might thus represent a novel mechanism of intestinal NBC activation by secretagogues.

Transport of volatile solutes through AQP1

PubMed Central

Cooper, Gordon J; Zhou, Yuehan; Bouyer, Patrice; Grichtchenko, Irina I; Boron, Walter F

2002-01-01

For almost a century it was generally assumed that the lipid phases of all biological membranes are freely permeable to gases. However, recent observations challenge this dogma. The apical membranes of epithelial cells exposed to hostile environments, such as gastric glands, have no demonstrable permeability to the gases CO2 and NH3. Additionally, the water channel protein aquaporin 1 (AQP1), expressed at high levels in erythrocytes, can increase membrane CO2 permeability when expressed in Xenopus oocytes. Similarly, nodulin-26, which is closely related to AQP1, can act as a conduit for NH3. A key question is whether aquaporins, which are abundant in virtually every tissue that transports O2 and CO2 at high levels, ever play a physiologically significant role in the transport of small volatile molecules. Preliminary data are consistent with the hypothesis that AQP1 enhances the reabsorption of HCO3− by the renal proximal tubule by increasing the CO2 permeability of the apical membrane. Other preliminary data on Xenopus oocytes heterologously expressing the electrogenic Na+-HCO3− cotransporter (NBC), AQP1 and carbonic anhydrases are consistent with the hypothesis that the macroscopic cotransport of Na+ plus two HCO3− occurs as NBC transports Na+ plus CO32- and AQP1 transports CO2 and H2O. Although data – obtained on AQP1 reconstituted into liposomes or on materials from AQP1 knockout mice – appear inconsistent with the model that AQP1 mediates substantial CO2 transport in certain preparations, the existence of unstirred layers or perfusion-limited conditions may have masked the contribution of AQP1 to CO2 permeability. PMID:12096045

News | Frederick National Laboratory for Cancer Research

Cancer.gov

Consortium aims to accelerate drug discovery process(Physics Today) Why big pharma and biotech are betting big on AI(NBC News) Scientists launch SF-based effort to dramatically cut cancer drug discovery time(SF Chronicle

Concussion: Doug Flutie: "Be on the Safe Side."

MedlinePlus

... of this page please turn JavaScript on. Feature: Concussion Doug Flutie: "Be on the Safe Side." Past ... for NBC Sports. Flutie is often asked about concussions and brain trauma associated with sports like football, ...

NREL: News - Director of National Bioenergy Center Named

Science.gov Websites

coordinating NREL's activities with bioenergy research at Oak Ridge National Laboratory (ORNL) and other organizations. Pacheco will represent the NBC, NREL, ORNL, DOE, and the interests of bioenergy programs to

Richard Bolin | NREL

Science.gov Websites

Bolin Photo of Richard Bolin Richard Bolin Manager, Partnership Development Group, National University Professional Experience Manager, Partnership Development Group, National Renewable Energy Group, NBC, 2009-present Acting Director/Commercialization Manager/ Market Analyst, NREL Technology

Comparison of CFD and operational dispersion models in an urban-like environment

NASA Astrophysics Data System (ADS)

Antonioni, G.; Burkhart, S.; Burman, J.; Dejoan, A.; Fusco, A.; Gaasbeek, R.; Gjesdal, T.; Jäppinen, A.; Riikonen, K.; Morra, P.; Parmhed, O.; Santiago, J. L.

2012-02-01

Chemical plants, refineries, transportation of hazardous materials are some of the most attractive facilities for external attacks aimed at the release of toxic substances. Dispersion of these substances into the atmosphere forms a concentration distribution of airborne pollutants with severe consequences for exposed individuals. For emergency preparedness and management, the availability of assessed/validated dispersion models, which can be able to predict concentration distribution and thus dangerous zones for exposed individuals, is of primary importance. Air quality models, integral models and analytical models predict the transport and the turbulent dispersion of gases or aerosols after their release without taking into account in detail the presence of obstacles. Obstacles can modify the velocity field and in turn the concentration field. The Computational Fluid Dynamics (CFD) models on the other hand are able to describe such phenomena, but they need to be correctly set up, tested and validated in order to obtain reliable results. Within the project Europa-ERG1 TA 113.034 "NBC Modelling and Simulation" several different approaches in CFD modelling of turbulent dispersion in closed, semi-confined and urban-like environment were adopted and compared with experimental data and with operational models. In this paper the results of a comparison between models describing the dispersion of a neutral gas in an idealized urban-like environment are presented and discussed. Experimental data available in the literature have been used as a benchmark for assessing statistical performance for each model. Selected experimental trials include some water channel tests, that were performed by Coanda at 1:205 scale, and one full-scale case that was tested in the fall of 2001 at the Dugway Proving Grounds in Utah, using an array of shipping containers. The paper also suggests the adoption of improved statistical parameters in order to better address differences between models, and to have a more straightforward method for comparing models suitable for emergency preparedness aims.

Audience Mail: Letters to an Anchorman

ERIC Educational Resources Information Center

Gans, Herbert J.

1977-01-01

Analyzes letters sent to John Chancellor and NBC Nightly News in October of 1975 in an attempt to identify writer characteristics, letter types, stories and issues to which the writers reacted and the reasons for writing the letters. (MH)

Biotransformation and biodegradation of selected nitroaromatics under anaerobic conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Razo-Flores, E.; Lettinga, G.; Field, J.A.

The fate of four nitroaromatic compounds (5-nitrosalicylate, 5NSA; 4-nitrobenzoate, 4NBc; 2,4-dinitrotoluene, 2,4DNT; nitrobenzene, NB) was studied in 160 mL laboratory-scale upward-flow anaerobic sludge bed reactors supplied with a mixture of volatile fatty acids and/or glucose as electron donors. All the nitroaromatics were transformed stoichiometrically to their corresponding aromatic amines. After prolonged reactor operation, 5NSA and 4NBc were completely mineralized to CH[sub 4] and CO[sub 2], whereas 2,4DNT was partially transformed to a nonidentified and nondegradable metabolite. Batch nitro-reduction experiments indicated that the position of the nitro group in relation to the other substituents in the aromatic ring plays a keymore » role in the rate of the nitro-group reduction. The results obtained indicate that certain nitroaromatic compounds can be completely mineralized and serve as a carbon and energy source for anaerobic bacteria.« less

Effects of Nb Modification and Cooling Rate on the Microstructure in an Ultrahigh Carbon Steel

NASA Astrophysics Data System (ADS)

Hecht, Matthew D.; Webler, Bryan A.; Picard, Yoosuf N.

2018-04-01

In this study, two different melting methods were used to investigate effects of Nb modification on microstructure in ultrahigh carbon steel (UHCS). Nb-free and Nb-modified UHCS samples were produced by melting and resolidifying an industrially produced base UHCS with and without addition of Nb powder. Microstructure was characterized using scanning electron microscopy, X-ray diffraction, and electron dispersive spectroscopy. Equilibrium computations of phase fractions and compositions were utilized to help describe microstructural changes caused by the Nb additions. Nb combined with C to form NbC structures before and during austenite solidification, reducing the effective amount of carbon available for the other phases. Cementite network spacing in the Nb-free samples was controlled by the cooling rate during solidification (faster cooling led to a more refined network). Network spacing in the Nb-modified UHCS could be enlarged by NbC structures that formed cooperatively with austenite.

Ultra high vacuum adhesion testing of NERVA engine materials

NASA Technical Reports Server (NTRS)

1970-01-01

The primary objective of this research program was to determine the effects of surface cleaning and deliberate gaseous contamination on the adhesion behavior of selected candidate materials for use in the NERVA nuclear rocket engine program. Using a torsion balance technique, the relationship between the normal compressive load applied to crossed rod samples and the resultant contact resistance was used to ascertain the extent of adhesion under each set of experimental conditions. In addition to an evaluation of the static adhesion behavior of selected materials combinations, the experimental apparatus was modified to permit a similar investigation relating to the effects of specific tangential displacements of the sample wires, i.e., their sliding friction behavior. During the course of this subcontract, the materials combinations 440 C vs. 440 C. pyrographite vs ZTA graphite, Nbc (graphite) vs. Nbc (graphite), and Electrolize Inconel 718 vs. Au electroplated 302 S/S were evaluated.

Effects of Nb Modification and Cooling Rate on the Microstructure in an Ultrahigh Carbon Steel

NASA Astrophysics Data System (ADS)

Hecht, Matthew D.; Webler, Bryan A.; Picard, Yoosuf N.

2018-06-01

In this study, two different melting methods were used to investigate effects of Nb modification on microstructure in ultrahigh carbon steel (UHCS). Nb-free and Nb-modified UHCS samples were produced by melting and resolidifying an industrially produced base UHCS with and without addition of Nb powder. Microstructure was characterized using scanning electron microscopy, X-ray diffraction, and electron dispersive spectroscopy. Equilibrium computations of phase fractions and compositions were utilized to help describe microstructural changes caused by the Nb additions. Nb combined with C to form NbC structures before and during austenite solidification, reducing the effective amount of carbon available for the other phases. Cementite network spacing in the Nb-free samples was controlled by the cooling rate during solidification (faster cooling led to a more refined network). Network spacing in the Nb-modified UHCS could be enlarged by NbC structures that formed cooperatively with austenite.

Dominance of Epsilonproteobacteria associated with a whale fall at a 4204 m depth - South Atlantic Ocean

NASA Astrophysics Data System (ADS)

Cavalett, Angélica; Silva, Marcus Adonai Castro da; Toyofuku, Takashi; Mendes, Rodrigo; Taketani, Rodrigo Gouvêa; Pedrini, Jéssica; Freitas, Robert Cardoso de; Sumida, Paulo Yukio Gomes; Yamanaka, Toshiro; Nagano, Yuriko; Pellizari, Vivian Helena; Perez, José Angel Alvarez; Kitazato, Hiroshi; Lima, André Oliveira de Souza

2017-12-01

The deep ocean is the largest marine environment on Earth and is home to a large reservoir of biodiversity. Within the deep ocean, large organic falls attract a suite of metazoans and microorganisms, which form an important community that, in part, relies on reduced chemical compounds. Here, we describe a deep-sea (4204 m) microbial community associated with sediments collected underneath a whale fall skeleton in the South Atlantic Ocean. Metagenomic analysis of 1 Gb of Illumina HiSeq. 2000 reads, including taxonomic and functional genes, was performed by using the MG-RAST pipeline, SEED, COG and the KEGG database. The results showed that Proteobacteria (79%) was the main phylum represented. The most dominant bacterial class in this phylum was Epsilonproteobacteria (69%), and Sulfurovum sp. NBC37-1 (97%) was the dominant species. Different species of Epsilonproteobacteria have been described in marine and terrestrial environments as important organisms for nutrient cycling. Functional analysis revealed key genes for nitrogen and sulfur cycles, including protein sequences for Sox system (sulfur oxidation) enzymes. These enzymes were mainly those of the Epsilonproteobacteria, indicating their importance for nitrogen and sulfur cycles and the balance of nutrients in this environment.

Synthesis and gas adsorption study of porous metal-organic framework materials

NASA Astrophysics Data System (ADS)

Mu, Bin

Metal-organic frameworks (MOFs) or porous coordination polymers (PCPs) have become the focus of intense study over the past decade due to their potential for advancing a variety of applications including air purification, gas storage, adsorption separations, catalysis, gas sensing, drug delivery, and so on. These materials have some distinct advantages over traditional porous materials such as the well-defined structures, uniform pore sizes, chemically functionalized sorption sites, and potential for postsynthetic modification, etc. Thus, synthesis and adsorption studies of porous MOFs have increased substantially in recent years. Among various prospective applications, air purification is one of the most immediate concerns, which has urgent requirements to improve current nuclear, biological, and chemical (NBC) filters involving commercial and military purposes. Thus, the major goal of this funded project is to search, synthesize, and test these novel hybrid porous materials for adsorptive removal of toxic industrial chemicals (TICs) and chemical warfare agents (CWAs), and to install the benchmark for new-generation NBC filters. The objective of this study is three-fold: (i) Advance our understanding of coordination chemistry by synthesizing novel MOFs and characterizing these porous coordination polymers; (ii) Evaluate porous MOF materials for gasadsorption applications including CO2 capture, CH4 storage, other light gas adsorption and separations, and examine the chemical and physical properties of these solid adsorbents including thermal stability and heat capacity of MOFs; (iii) Evaluate porous MOF materials for next-generation NBC filter media by adsorption breakthrough measurements of TICs on MOFs, and advance our understanding about structureproperty relationships of these novel adsorbents.

Report on the Evaluation Results of the Course "Mechanic Undercarriage Leopard 2"

DTIC Science & Technology

1998-01-14

is onderdeel van TNO Defensieonderzoek waartoe verder behoren: TNO Fysisch en Elektronisch Laboratorium TNO Prins Maurits Laboratorium ...beroepsonderwijs MFO Militaire Functie Opleiding NBC Nucleair Biologisch Chemisch OCLOG Onderwijs Centrum Logistiek OCTD Onderhouds Centrum Technische

Study on GIS Visualization in Evaluation of the Human Living Environment in Shenyang-Dalian Urban Agglomeration

PubMed Central

Hou, Kang; Zhou, Jieting; Li, Xuxiang; Ge, Shengbin

2016-01-01

Analysis of human living environmental quality of Shenyang-Dalian urban agglomerations has important theoretical and practical significance in rapid development region. A lot of investigations have been carried for Shenyang-Dalian urban agglomerations, including 38 counties. Based on the carrying capacity of resources, natural and socioeconomic environmental factors and regional changes of human living environmental evaluation are analyzed with the application of geographic information systems (GIS) software. By using principal component analysis (PCA) model and natural breaks classification (NBC) method, the evaluation results are divided into five categories. The results show that the human living environmental evaluation (HLEE) indexes of Dalian, Shenyang, and Liaoyang are higher than other counties. Among these counties, the human living environmental evaluation (HLEE) indexes of coastal counties are significantly higher than inland counties. The range of the human living environmental evaluation index in most of the study area is at III, IV, and V levels, accounting for 80.01%. Based on these results, it could illustrate the human living environment is in relatively suitable condition in Shenyang-Dalian urban agglomeration. PMID:27200212

Effect of Cooling Rate on Phase Transformations in a High-Strength Low-Alloy Steel Studied from the Liquid Phase

NASA Astrophysics Data System (ADS)

Dorin, Thomas; Stanford, Nicole; Taylor, Adam; Hodgson, Peter

2015-12-01

The phase transformation and precipitation in a high-strength low-alloy steel have been studied over a large range of cooling rates, and a continuous cooling transformation (CCT) diagram has been produced. These experiments are unique because the measurements were made from samples cooled directly from the melt, rather than in homogenized and re-heated billets. The purpose of this experimental design was to examine conditions pertinent to direct strip casting. At the highest cooling rates which simulate strip casting, the microstructure was fully bainitic with small regions of pearlite. At lower cooling rates, the fraction of polygonal ferrite increased and the pearlite regions became larger. The CCT diagram and the microstructural analysis showed that the precipitation of NbC is suppressed at high cooling rates, and is likely to be incomplete at intermediate cooling rates.

Thermal evolution of the western South Atlantic and the adjacent continent during Termination 1

NASA Astrophysics Data System (ADS)

Chiessi, C. M.; Mulitza, S.; Mollenhauer, G.; Silva, J. B.; Groeneveld, J.; Prange, M.

2014-12-01

During Termination 1, millennial-scale weakening events of the Atlantic meridional overturning circulation (AMOC) supposedly produced major changes in sea surface temperatures (SST) of the western South Atlantic, and in mean air temperatures (MAT) over southeastern South America. It was suggested, for instance, that the Brazil Current (BC) would strengthen (weaken) and the North Brazil Current (NBC) would weaken (strengthen) during slowdown (speed-up) events of the AMOC. This anti-phase pattern was claimed to be a necessary response to the decreased North Atlantic heat piracy during periods of weak AMOC. However, the thermal evolution of the western South Atlantic and the adjacent continent is largely unknown and a compelling record of the BC-NBC anti-phase behavior remains elusive. Here we address this issue, presenting high temporal resolution SST and MAT records from the BC and southeastern South America, respectively. We identify a warming in the western South Atlantic during Heinrich Stadial 1 (HS1), which is followed first by a drop and then by increasing temperatures during the Bølling-Allerød, in-phase with an existing NBC record. Additionally, a similar SST evolution is shown by a southernmost eastern South Atlantic record, suggesting a South Atlantic-wide pattern in SST evolution during most of Termination 1. Over southeastern South America, our MAT record shows a two-step increase during Termination 1, synchronous with atmospheric CO2 rise (i.e., during the second half of HS1 and during the Younger Dryas), and lagging abrupt SST changes by several thousand years. This delay corroborates the notion that the long duration of HS1 was fundamental to drive the Earth out of the last glacial.

Hand immersion in cold water alleviating physiological strain and increasing tolerance to uncompensable heat stress.

PubMed

Khomenok, Gennadi A; Hadid, Amir; Preiss-Bloom, Orahn; Yanovich, Ran; Erlich, Tomer; Ron-Tal, Osnat; Peled, Amir; Epstein, Yoram; Moran, Daniel S

2008-09-01

The current study examines the use of hand immersion in cold water to alleviate physiological strain caused by exercising in a hot climate while wearing NBC protective garments. Seventeen heat acclimated subjects wearing a semi-permeable NBC protective garment and a light bulletproof vest were exposed to a 125 min exercise-heat stress (35 degrees C, 50% RH; 5 km/h, 5% incline). The heat stress exposure routine included 5 min rest in the chamber followed by two 50:10 min work-rest cycles. During the control trial (CO), there was no intervention, whilst in the intervention condition the subjects immersed their hands and forearms in a 10 degrees C water bath (HI). The results demonstrated that hand immersion in cold water significantly reduced physiological strain. In the CO exposure during the first and second resting periods, the average rectal temperature (T (re)) practically did not decrease. With hand immersion, the mean (SD) T (re) decreased by 0.45 (0.05 degrees C) and 0.48 degrees C (0.06 degrees C) during the first and second rest periods respectively (P < 0.005). Significant decreases in skin temperature, sweat rate, heart rate, and heat storage was also noted in the HI vs. the CO trials. Tolerance time in the HI exposure were longer than in the CO exposure (only 12 subjects in the CO trial endured the entire heat exposure session, as opposed to all 17 subjects in the HI group). It is concluded that hand immersion in cold water for 10 min is an effective method for decreasing the physiological strain caused by exercising under heat stress while wearing NBC protective garments. The method is convenient, simple, and allows longer working periods in hot or contaminated areas with shorter resting periods.

Digestion of a single meal affects gene expression of ion and ammonia transporters and glutamine synthetase activity in the gastrointestinal tract of freshwater rainbow trout.

PubMed

Bucking, Carol; Wood, Chris M

2012-04-01

Experiments on freshwater rainbow trout, Oncorhynchus mykiss, demonstrated how digestion affected the transcriptional expression of gastrointestinal transporters following a single satiating meal (~3% body mass ration) after a 1-week fast. Quantitative real-time polymerase chain reaction was employed to measure the relative mRNA expression of three previously cloned and sequenced transporters [H(+)-K(+)-ATPase (HKA), Na(+)/HCO(3)(-) cotransporter (NBC), and the Rhesus glycoprotein (Rhbg1; an ammonia transporter)] over a 24-h time course following feeding. Plasma total ammonia increased about threefold from pre-feeding levels to 288 μmol l(-1), whereas total ammonia levels in chyme supernatant reached a sixfold higher value (1.8 mmol l(-1)) than plasma levels. Feeding did not appear to have a statistically significant effect on the relative mRNA expression of the gastric HKA or Rhbg1. However, the relative mRNA expression of gastric NBC was increased 24 h following the ingestion of a meal. Along the intestinal tract, feeding increased the relative mRNA expression of Rhbg1, but had no effect on the expression of NBC. Expression of the gastric HKA was undetectable in the intestinal tract of freshwater rainbow trout. Digestion increased the activity of glutamine synthetase in the posterior intestine at 12 and 24 h following feeding. This study is among the first to show that there are digestion-associated changes in gene expression and enzyme activity in the gastrointestinal tract of teleost fish illustrating the dynamic plasticity of this organ. These post-prandial changes occur over the relative short-term duration of digesting a single meal.

Leadership in Broadcasting.

ERIC Educational Resources Information Center

Silverman, Fred

The objective for the National Broadcasting Company (NBC) is leadership that grows from excellence. This type of leadership requires that the network serve the diversity of the total population, present programs that develop new approaches to viewers' interests, strive for excellence in craftsmanship, program content, and management, and exercise…

41 CFR 128-1.8005 - Seismic safety standards.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the model building codes that the Interagency Committee on Seismic Safety in Construction (ICSSC...) Uniform Building Code (UBC); (2) The 1992 Supplement to the Building Officials and Code Administrators International (BOCA) National Building Code (NBC); and (3) The 1992 Amendments to the Southern Building Code...

41 CFR 128-1.8005 - Seismic safety standards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the model building codes that the Interagency Committee on Seismic Safety in Construction (ICSSC...) Uniform Building Code (UBC); (2) The 1992 Supplement to the Building Officials and Code Administrators International (BOCA) National Building Code (NBC); and (3) The 1992 Amendments to the Southern Building Code...

41 CFR 128-1.8005 - Seismic safety standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the model building codes that the Interagency Committee on Seismic Safety in Construction (ICSSC...) Uniform Building Code (UBC); (2) The 1992 Supplement to the Building Officials and Code Administrators International (BOCA) National Building Code (NBC); and (3) The 1992 Amendments to the Southern Building Code...

41 CFR 128-1.8005 - Seismic safety standards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the model building codes that the Interagency Committee on Seismic Safety in Construction (ICSSC...) Uniform Building Code (UBC); (2) The 1992 Supplement to the Building Officials and Code Administrators International (BOCA) National Building Code (NBC); and (3) The 1992 Amendments to the Southern Building Code...

Experimental Study of the Microstructure and Micromechanical Properties of Laser Cladded Ni-based Amorphous Composite Coatings

NASA Astrophysics Data System (ADS)

Li, Ruifeng; Zheng, Qichi; Zhu, Yanyan; Li, Zhuguo; Feng, Kai; Liu, Chuan

2018-01-01

(Ni0.6Fe0.4)65B18Si10Nb4C3 amorphous composite coating was successfully fabricated on AISI 1045 steel substrate by using laser cladding process with coaxial powder feeding equipment. The microstructure and phase distribution of the coating were investigated by using x-ray diffraction, scanning electron microscopy and transmission electron microscope. The mechanical properties of the coating were examined by using microhardness testing and nanoindentation. The experimental results indicated that the volume fraction of amorphous phase increased with the decrease in laser cladding heat input, leading to an improvement of mean microhardness and nanohardness. NbC particles in a size ranging between 150 and 1650 nm were found embedding in the amorphous composite coatings in all situations. The presence of the NbC particles can contribute to an improvement of 96.7 HV in hardness on the basis of experimental results, while theoretical prediction suggests an improvement of 92.5 HV by using Orowan-Ashby equation.

Low-cost high-quality Fe-based shape memory alloys suitable for pipe joints

NASA Astrophysics Data System (ADS)

Kajiwara, Setsuo; Baruj, Albert L.; Kikuchi, Takehiko; Shinya, Norio

2003-08-01

By addition of small amount of Nb and C to the conventional Fe-Mn-Si based shape memory alloys, shape memory properties are greatly improved in such an extent that the costly 'training' heat treatment is no more necessary. The key to this remarkable improvement of shape memory effect is to produce small NbC precipitates of about several nm in size in austenite. In order to generate such very small NbC particles, the sample is firstly rolled at 870 K and then aged at 1070 K. An example of Fe-28Mn-6Si-5Cr-0.53Nb-0.06C (mass %) alloy is shown; 95% shape recovery for initial strain of 4% is obtained and the shape recovery stress of about 300 MPa is attained for the sample pre-rolled 14%, which is well above the criterion for industry application of pipe jointing. A pipe jointing with this material is demonstrated.

Corrosion behavior of ferritic stainless steel with 15wt% chromium for the automobile exhaust system

NASA Astrophysics Data System (ADS)

Li, Hua-bing; Jiang, Zhou-hua; Feng, Hao; Zhu, Hong-chun; Sun, Bin-han; Li, Zhen

2013-09-01

The effect of chloride ion concentration, pH value, and grain size on the pitting corrosion resistance of a new ferritic stainless steel with 15wt% Cr was investigated using the anodic polarization method. The semiconducting properties of passive films with different chloride ion concentrations were performed using capacitance measurement and Mott-Schottky analysis methods. The aging precipitation and intergranular corrosion behavior were evaluated at 400-900°C. It is found that the pitting potential decreases when the grain size increases. With the increase in chloride ion concentration, the doping density and the flat-bland potential increase but the thickness of the space charge layer decreases. The pitting corrosion resistance increases rapidly with the decrease in pH value. Precipitants is identified as Nb(C,N) and NbC, rather than Cr-carbide. The intergranular corrosion is attributed to the synergistic effects of Nb(C,N) and NbC precipitates and Cr segregation adjacent to the precipitates.

Estrogen Metabolism and Exposure in a Genotypic-Phenotypic Model for Breast Cancer Risk Prediction

PubMed Central

Crooke, Philip S.; Justenhoven, Christina; Brauch, Hiltrud; Dawling, Sheila; Roodi, Nady; Higginbotham, Kathryn S. P.; Plummer, W. Dale; Schuyler, Peggy A.; Sanders, Melinda E; Page, David L.; Smith, Jeffrey R.; Dupont, William D.; Parl, Fritz F.

2012-01-01

Background Current models of breast cancer risk prediction do not directly reflect mammary estrogen metabolism or genetic variability in exposure to carcinogenic estrogen metabolites. Methods We developed a model that simulates the kinetic effect of genetic variants of the enzymes CYP1A1, CYP1B1, and COMT on the production of the main carcinogenic estrogen metabolite, 4-hydroxyestradiol (4-OHE2), expressed as area under the curve metric (4-OHE2-AUC). The model also incorporates phenotypic factors (age, body mass index, hormone replacement therapy, oral contraceptives, family history), which plausibly influence estrogen metabolism and the production of 4-OHE2. We applied the model to two independent, population-based breast cancer case-control groups, the German GENICA study (967 cases, 971 controls) and the Nashville Breast Cohort (NBC; 465 cases, 885 controls). Results In the GENICA study, premenopausal women at the 90th percentile of 4-OHE2-AUC among control subjects had a risk of breast cancer that was 2.30 times that of women at the 10th control 4-OHE2-AUC percentile (95% CI 1.7 – 3.2, P = 2.9 × 10−7). This relative risk was 1.89 (95% CI 1.5 – 2.4, P = 2.2 × 10−8) in postmenopausal women. In the NBC, this relative risk in postmenopausal women was 1.81 (95% CI 1.3 – 2.6, P = 7.6 × 10−4), which increased to 1.83 (95% CI 1.4 – 2.3, P = 9.5 × 10−7) when a history of proliferative breast disease was included in the model. Conclusions The model combines genotypic and phenotypic factors involved in carcinogenic estrogen metabolite production and cumulative estrogen exposure to predict breast cancer risk. Impact The estrogen carcinogenesis-based model has the potential to provide personalized risk estimates. PMID:21610218

An Atom Probe Tomographic Investigation of High-Strength, High-Toughness Precipitation Strengthened Steels for Naval Applications

NASA Astrophysics Data System (ADS)

Hunter, Allen H.

Novel high-strength high-toughness alloys strengthened by precipitation are investigated for use in naval applications. The mechanical properties of an experimental steel alloy, NUCu-140, are evaluated and are not suitable for the naval requirements due to poor impact toughness at -40°C. An investigation is conducted to determine optimum processing conditions to restore toughness. A detailed aging study is conducted at 450, 500, and 550°C to determine the evolution of the microstructure and mechanical properties. A combination of transmission electron microscopy (TEM), synchrotron X-ray Diffraction (XRD), and Local electrode atom probe (LEAP) tomography are used to measure the evolution of the Cu precipitates, austenite, NbC, and cementite phases during aging. The evolution of the Cu precipitates significantly affects the yield strength of the steel, but low temperature toughness is controlled by the cementite precipitates. Extended aging is effective at improving the impact toughness but the yield strength is also decreased due to coarsening of the Cu precipitates. To provide a foundation for successful welding of NUCu-140 steel, an investigation of the effects of gas metal arc welding (GMAW) are performed. The microstructures in the base metal (BM), heat affected zone (HAZ), and fusion zone (FZ) of a GMAW sample are analyzed to determine the effects of the welding thermal cycle. Weld simulation samples with known thermal histories are prepared and analyzed by XRD and LEAP tomography. A significant loss in microhardness is observed as a result of dissolution of the Cu precipitates after the weld thermal cycle. The cooling time is too rapid to allow significant precipitation of Cu. In addition to the NUCu-140 alloy, a production HSLA-115 steel alloy is investigated using TEM, XRD, and LEAP tomography. The strength of the HSLA-115 is found to be derived primarily from Cu precipitates. The volume fractions of cementite, austenite, and NbC are measured by XRD. Austenite precipitates are observed at martensite lath boundaries using TEM.

On the propagation and decay of North Brazil Current rings

NASA Astrophysics Data System (ADS)

Jochumsen, Kerstin; Rhein, Monika; Hüttl-Kabus, Sabine; BöNing, Claus W.

2010-10-01

Near the western boundary of the tropical North Atlantic, where the North Brazil Current (NBC) retroflects into the North Equatorial Countercurrent, large anticyclonic rings are shed. After separating from the retroflection region, the so-called NBC rings travel northwestward along the Brazilian coast, until they reach the island chain of the Lesser Antilles and disintegrate. These rings contribute substantially to the upper limb return flow of the Atlantic Meridional Overturning Circulation by carrying South Atlantic Water into the northern subtropical gyre. Their relevance for the northward transport of South Atlantic Water depends on the frequency of their generation as well as on their horizontal and vertical structure. The ring shedding and propagation and the complex interaction of the rings with the Lesser Antilles are investigated in the ? Family of Linked Atlantic Model Experiments (FLAME) model. The ring properties simulated in FLAME reach the upper limit of the observed rings in diameter and agree with recent observations on seasonal variability, which indicates a maximum shedding during the first half of the year. When the rings reach the shallow topography of the Lesser Antilles, they are trapped by the island triangle of St. Lucia, Barbados and Tobago and interact with the island chain. The model provides a resolution that is capable of resolving the complex topographic conditions at the islands and illuminates various possible fates for the water contained in the rings. It also reproduces laboratory experiments that indicate that both cyclones and anticyclones are formed after a ring passes through a topographic gap. Trajectories of artificial floats, which were inserted into the modeled velocity field, are used to investigate the pathways of the ring cores and their fate after they encounter the Lesser Antilles. The majority of the floats entered the Caribbean, while the northward Atlantic pathway was found to be of minor importance. No prominent pathway was found east of Barbados, where a ring could avoid the interaction with the islands and migrate toward the northern Lesser Antilles undisturbed.

Taiwan: America’s Next War?

DTIC Science & Technology

1998-04-08

7. 29 Megatrends China, Beijing: Hauling Publishing House, May 1996, as cited in Richard Bernstein and Ross H. Munro, The Coming Conflict with...other economic interests in Asia  To prevent, deter and reduce the threat of nuclear, biological , and chemical (NBC) attacks on the U.S. and its

Mary Ann Franden | NREL

Science.gov Websites

Ann Franden Photo of Mary Ann Franden Mary Franden Researcher IV-Molecular Biology Mary.Ann.Franden @nrel.gov | 303-384-7767 Research Interests Mary Ann Franden is a senior scientist in the Applied Biology University Professional Experience Senior Scientist, NREL, NBC, Applied Biology Group Professional Research

USSR and Eastern Europe Scientifc Abstracts Materials Science and Metallurgy No 43.

DTIC Science & Technology

1977-03-09

Institute [Abstract] A study is made of the influence of stoichiometry on the characteristics of microplastic deformation in powders of zirconium and... microplasticity , stoichiometric carbides can be arranged in the following sequence of increasing brittleness: NbC, ZrC, TiC. References 18: 13 Soviet

Televised Television Literacy.

ERIC Educational Resources Information Center

Dorr, Aimee; And Others

Ninety-four children, aged 5 to 12 years, were subjects of a study of recall of television literacy messages (drop-ins). The 30-second "How To Watch TV" (HTWTV) segments were designed for broadcast on Saturday mornings by the National Broadcasting Company (NBC) to convey to children some information and values about television (e.g., animals do…

Designing a Classification System for Internet Offenders: Doing Cognitive Distortions

ERIC Educational Resources Information Center

Hundersmarck, Steven F.; Durkin, Keith F.; Delong, Ronald L.

2007-01-01

Televised features such as NBC's "To Catch a Predator" have highlighted the growing problem posed by Internet sexual predators. This paper reports on the authors' attempts in designing a classification system for Internet offenders. The classification system was designed based on existing theory, understanding the nature of Internet offenders and…

Liability of College Faculty and Administrators

ERIC Educational Resources Information Center

Wall, Patricia S.; Sarver, Lee

2014-01-01

According to a "Wall Street Journal"/NBC News poll, 59 percent of all adults consider education essential to getting ahead in life. At the same time, an increasing number of adults have begun to blame educators for their failure in life, claiming educational malpractice. Historically, education has been more of an issue at the state and…

Standard First Aid Training Course. Naval Education and Training Command Rate Training Manual.

ERIC Educational Resources Information Center

Naval Education and Training Command, Washington, DC.

This first aid manual is designed to serve as basic first aid instructional materials for all nonmedical naval personnel. Chapters are included on the following topics: basic life support, hemorrhage, shock, wounds, injuries, drug abuse, poisoning, common medical emergencies, NBC (nuclear, biological, chemical) agent casualties, and rescue and…

Rovibronically Selected and Resolved Laser Photoionization and Photoelectron Studies of Transition Metal Carbides, Nitrides, and Oxides.

NASA Astrophysics Data System (ADS)

Luo, Zhihong; Chang, Yih-Chung; Huang, Huang; Ng, Cheuk-Yiu

2014-06-01

Transition metal (M) carbides, nitrides, and oxides (MX, X = C, N, and O) are important molecules in astrophysics, catalysis, and organometallic chemistry. The measurements of the ionization energies (IEs), bond energies, and spectroscopic constants for MX/MX+ in the gas phase by high-resolution photoelectron methods represent challenging but profitable approaches to gain fundamental understandings of the electronic structures and bonding properties of these compounds and their cations. We have developed a two-color laser excitation scheme for high-resolution pulse field ionization photoelectron (PFI-PE) measurements of MX species. By exciting the neutral MX species to a single rovibronic state using a visible laser prior to photoionization by a UV laser, we have obtained fully rotational resolved PFI-PE spectra for TiC+, TiO+, VCH+, VN+, CoC+, ZrO+, and NbC+. The unambiguous rotational assignments of these spectra have provided highly accurate IE values for TiC, TiO, VCH, VN, CoC, ZrO, and NbC, and spectroscopic constants for their cations.

Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)

PubMed Central

De Giusti, V. C.; Caldiz, C. I.; Ennis, I. L.; Pérez, N. G.; Cingolani, H. E.; Aiello, E. A.

2013-01-01

Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signaling molecules that mediate different intracellular pathways has gained increasing interest among physiologists in the last years. In our lab, we have been studying the participation of mitochondrial ROS in the intracellular pathways triggered by the renin-angiotensin II-aldosterone system (RAAS) in the myocardium during the past few years. We have demonstrated that acute activation of cardiac RAAS induces mitochondrial ATP-dependent potassium channel (mitoKATP) opening with the consequent enhanced production of mitochondrial ROS. These oxidant molecules, in turn, activate membrane transporters, as sodium/hydrogen exchanger (NHE-1) and sodium/bicarbonate cotransporter (NBC) via the stimulation of the ROS-sensitive MAPK cascade. The stimulation of such effectors leads to an increase in cardiac contractility. In addition, it is feasible to suggest that a sustained enhanced production of mitochondrial ROS induced by chronic cardiac RAAS, and hence, chronic NHE-1 and NBC stimulation, would also result in the development of cardiac hypertrophy. PMID:23755021

Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS).

PubMed

De Giusti, V C; Caldiz, C I; Ennis, I L; Pérez, N G; Cingolani, H E; Aiello, E A

2013-01-01

Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signaling molecules that mediate different intracellular pathways has gained increasing interest among physiologists in the last years. In our lab, we have been studying the participation of mitochondrial ROS in the intracellular pathways triggered by the renin-angiotensin II-aldosterone system (RAAS) in the myocardium during the past few years. We have demonstrated that acute activation of cardiac RAAS induces mitochondrial ATP-dependent potassium channel (mitoKATP) opening with the consequent enhanced production of mitochondrial ROS. These oxidant molecules, in turn, activate membrane transporters, as sodium/hydrogen exchanger (NHE-1) and sodium/bicarbonate cotransporter (NBC) via the stimulation of the ROS-sensitive MAPK cascade. The stimulation of such effectors leads to an increase in cardiac contractility. In addition, it is feasible to suggest that a sustained enhanced production of mitochondrial ROS induced by chronic cardiac RAAS, and hence, chronic NHE-1 and NBC stimulation, would also result in the development of cardiac hypertrophy.

Discrimination of premalignant lesions and cancer tissues from normal gastric tissues using Raman spectroscopy

NASA Astrophysics Data System (ADS)

Luo, Shuwen; Chen, Changshui; Mao, Hua; Jin, Shaoqin

2013-06-01

The feasibility of early detection of gastric cancer using near-infrared (NIR) Raman spectroscopy (RS) by distinguishing premalignant lesions (adenomatous polyp, n=27) and cancer tissues (adenocarcinoma, n=33) from normal gastric tissues (n=45) is evaluated. Significant differences in Raman spectra are observed among the normal, adenomatous polyp, and adenocarcinoma gastric tissues at 936, 1003, 1032, 1174, 1208, 1323, 1335, 1450, and 1655 cm-1. Diverse statistical methods are employed to develop effective diagnostic algorithms for classifying the Raman spectra of different types of ex vivo gastric tissues, including principal component analysis (PCA), linear discriminant analysis (LDA), and naive Bayesian classifier (NBC) techniques. Compared with PCA-LDA algorithms, PCA-NBC techniques together with leave-one-out, cross-validation method provide better discriminative results of normal, adenomatous polyp, and adenocarcinoma gastric tissues, resulting in superior sensitivities of 96.3%, 96.9%, and 96.9%, and specificities of 93%, 100%, and 95.2%, respectively. Therefore, NIR RS associated with multivariate statistical algorithms has the potential for early diagnosis of gastric premalignant lesions and cancer tissues in molecular level.

[Mechanism of protective effects of tumor necrosis factor receptor associated protein 1 on hypoxic cardiomyocytes of rats].

PubMed

Xiang, F; Zhang, D X; Ma, S Y; Huang, Y S

2016-12-20

Objective: To investigate the mechanism of protective effects of tumor necrosis factor receptor associated protein 1 (TRAP1) on hypoxic cardiomyocytes of rats. Methods: Primary cultured cardiomyocytes were obtained from neonatal Sprague-Dawley rats (aged 1 to 3 days) and then used in the following experiments. (1) Cells were divided into group TRAP1 and control group according to the random number table (the same grouping method below), and then the total protein of cells was extracted. Total protein of cells in group TRAP1 was added with mouse anti-rat TRAP1 monoclonal antibody, while that in control group was added with the same type of IgG from mouse. Co-immunoprecipitation and protein mass spectrography analysis were used to determine the possible proteins interacted with TRAP1. (2) Cells were divided into normoxia blank control group (NBC), normoxia+ TRAP1 interference control group (NTIC), normoxia+ TRAP1 interference group (NTI), normoxia+ TRAP1 over-expression control group (NTOC), and normoxia+ TRAP1 over-expression group (NTO), with 1 well in each group. Cells in group NBC were routinely cultured, while cells in the latter four groups were respectively added with TRAP1 RNA interference empty virus vector, TRAP1 RNA interference adenovirus vector, TRAP1 over-expression empty virus vector, and TRAP1 over-expression adenovirus vector. Another batch of cells were divided into group NBC, hypoxic blank control group (HBC), hypoxic+ TRAP1 interference control group (HTIC), hypoxic+ TRAP1 interference group (HTI), hypoxic+ TRAP1 over-expression control group (HTOC), and hypoxic+ TRAP1 over-expression group (HTO), with 1 well in each group. Cells in hypoxic groups were under hypoxic condition for 6 hours after being treated as those in the corresponding normoxia groups, respectively. The mRNA expression of cytochrome c oxidase subunit Ⅱ (COXⅡ) of cells in each group was detected by real time fluorescent quantitive reverse transcription polymerase chain reaction. Experiments were repeated for three times. (3) Cells were divided into group NBC, group HBC, group HTOC, group HTO, hypoxic+ TRAP1 over-expression+ COXⅡinterference control group (HTOCIC), and hypoxic+ TRAP1 over-expression+ COXⅡinterference group (HTOCI), with 3 wells in each group. Cells in the previous 4 groups were treated as those in experiment (2). Cells in group HTOCIC and HTOCI were respectively transfected with COXⅡ RNA interference empty virus vector and COXⅡ RNA interference adenovirus vector, and then both added with TRAP1 over-expression adenovirus vector. The proliferation activity of cells was determined by cell counting kit 8 and microplate reader, and the ratio of death cells was measured by propidium lodide and Hoechst 33342 staining. Another batch of cells were divided into group NBC, group HBC, group HTIC, group HTI, hypoxic+ TRAP1 interference+ COXⅡover-expression control group (HTICOC), and hypoxic+ TRAP1 interference+ COXⅡ over-expression group (HTICO), with 3 wells in each group. Cells in the previous 4 groups were treated as those in experiment (2). Cells in group HTICOC and HTICO were both transfected with TRAP1 RNA interference adenovirus vector, and then respectively added with COXⅡ over-expression empty virus vector and COXⅡ over-expression adenovirus vector. The proliferation activity of cells and the ratio of death cells were detected as before. Experiments were repeated for three times. Data were processed with one-way analysis of variance and LSD test. Results: (1) The expression of TRAP1 was found in cells of group TRAP1, while that was not found in cells of control group. The possible proteins interacted with TRAP1 were keratin, COXⅡ, and an unknown protein with predicted molecular weight 13×10 3 . (2) Compared with that in group NBC, the mRNA expression of COXⅡof cells had no significant change in group NTIC and group NTOC (with P values above 0.05), but significantly decreased in group NTI ( P <0.01), and significantly increased in group NTO ( P <0.01). Compared with that in group NBC, the mRNA expression of COXⅡof cells in group HBC was significantly decreased ( P <0.01). Compared with that in group HBC, the mRNA expression of COXⅡof cells had no significant change in group HTIC and group HTOC (with P values above 0.05), but significantly decreased in group HTI ( P <0.01), and significantly increased in group HTO ( P <0.01). (3) The proliferation activity of cells in group NBC, group HBC, group HTOC, group HTO, group HTOCIC, and group HTOCI was respectively 0.498±0.022, 0.303±0.018, 0.313±0.032, 0.456±0.031, 0.448±0.034, and 0.335±0.026, and the ratios of death cells in above groups were respectively (4.7±1.5)%, (24.7±3.1)%, (26.0±2.7)%, (13.3±2.5)%, (12.7±2.1)%, and (21.0±1.7)%. Compared with those in group NBC, the proliferation activity of cells in HBC was decreased, while the ratio of death cells was increased (with P values below 0.01). Compared with those in group HBC, the proliferation activity of cells and the ratio of death cells in group HTOC had no significant change (with P values above 0.05), while the proliferation activity of cells was increased and the ratio of death cells was decreased in group HTO (with P values below 0.01). Compared with those in group HTO, the proliferation activity of cells and the ratio of death cells in group HTOCIC had no significant change (with P values above 0.05), while the proliferation activity of cells was decreased and the ratio of death cells was increased in group HTOCI (with P values below 0.01). (4) The proliferation activity of cells in group NBC, group HBC, group HTIC, group HTI, group HTICOC, and group HTICO was respectively 0.444±0.025, 0.275±0.016, 0.283±0.021, 0.150±0.009, 0.135±0.011, and 0.237±0.017, and the ratios of death cells in above groups were respectively (3.7±0.6)%, (21.0±2.7)%, (20.3±3.1)%, (31.7±2.5)%, (33.3±3.2)%, and (19.3±1.5)%. Compared with those in group HBC, the proliferation activity of cells and the ratio of death cells in group HTIC had no significant change (with P values above 0.05). Compared with those in group HBC and group HTIC, the proliferation activity of cells was decreased and the ratio of death cells was significantly increased in group HTI (with P values below 0.01). Compared with those in group HTI, the proliferation activity of cells and the ratio of death cells in group HTICOC had no significant change (with P values above 0.05), while the proliferation activity of cells was increased and the ratio of death cells was significantly decreased in group HTICO (with P values below 0.01). Conclusions: TRAP1 can up-regulate the expression of COXⅡ mRNA, and COXⅡ is one of the downstream effector molecules that TRAP1 mediates its protective effects on hypoxic cardiomyocytes.

Kerr microscopy studies of the effects of bending stress on galfenola)

NASA Astrophysics Data System (ADS)

Raghunath, Ganesh; Marana, Michael; Na, Suok-Min; Flatau, Alison

2014-05-01

This work deals with using a magneto-optic Kerr effect (MOKE) microscope to optically analyze the evolution of magnetic domains in a rolled and Goss textured galfenol (Fe81Ga19 + 1.0% NbC) sample when subjected to a bending stress. The initial magnetization state of the cantilevered sample was fixed along its length by a 0.3 T permanent magnet. The magnetic state was monitored with the MOKE microscope as a tip load was applied to bend the sample. The magnetic state of galfenol depends on its magneto-elastic properties. A finite element model that incorporates an energy based formulation of magnetostriction [W. D. Armstrong, J. Magn. Magn. Mater. 263(1-2), 208-218 (2003)] was used to investigate the stresses in the sample and the corresponding change in the magnetic induction as bending occurred. A qualitative comparison with the domain pictures is presented, and the experimental micromagnetic behavior results are shown to correlate well to the macro scale bending stress and magnetization results obtained in the FEM simulations.

Intracellular Acid-Extruding Regulators and the Effect of Lipopolysaccharide in Cultured Human Renal Artery Smooth Muscle Cells

PubMed Central

Loh, Shih-Hurng; Lee, Chung-Yi; Tsai, Yi-Ting; Shih, Shou-Jou; Chen, Li-Wei; Cheng, Tzu-Hurng; Chang, Chung-Yi; Tsai, Chein-Sung

2014-01-01

Homeostasis of the intracellular pH (pHi) in mammalian cells plays a pivotal role in maintaining cell function. Thus far, the housekeeping Na+-H+ exchanger (NHE) and the Na+-HCO3 − co-transporter (NBC) have been confirmed in many mammalian cells as major acid extruders. However, the role of acid-extruding regulators in human renal artery smooth muscle cells (HRASMCs) remains unclear. It has been demonstrated that lipopolysaccharide (LPS)-induced vascular occlusion is associated with the apoptosis, activating calpain and increased [Ca2+]i that are related to NHE1 activity in endothelia cells. This study determines the acid-extruding mechanisms and the effect of LPS on the resting pHi and active acid extruders in cultured HRASMCs. The mechanism of pHi recovery from intracellular acidosis (induced by NH4Cl-prepulse) is determined using BCECF-fluorescence in cultured HRASMCs. It is seen that (a) the resting pHi is 7.19±0.03 and 7.10±0.02 for HEPES- and CO2/HCO3 −- buffered solution, respectively; (b) apart from the housekeeping NHE1, another Na+-coupled HCO3 − transporter i.e. NBC, functionally co-exists to achieve acid-equivalent extrusion; (c) three different isoforms of NBC: NBCn1 (SLC4A7; electroneutral), NBCe1 (SLC4A4; electrogenic) and NBCe2 (SLC4A5), are detected in protein/mRNA level; and (d) pHi and NHE protein expression/activity are significantly increased by LPS, in both a dose- and time- dependent manner, but NBCs protein expression is not. In conclusion, it is demonstrated, for the first time, that four pHi acid-extruding regulators: NHE1, NBCn1, NBCe1 and NBCe2, co-exist in cultured HRASMCs. LPS also increases cellular growth, pHi and NHE in a dose- and time-dependent manner. PMID:24587308

Functional characterization of intracellular pH regulators responsible for acid extrusion in human radial artery smooth muscle cells.

PubMed

Lee, Chung-Yi; Tsai, Yi-Ting; Chang, Chung-Yi; Chang, Yi-Yu; Cheng, Tzu-Hurng; Tsai, Chien-Sung; Loh, Shih-Hurng

2014-10-31

Intracellular pH (pHi) is a critical factor influencing many important cellular functions. Acid extrusion carriers such as an Na⁺/H⁺ exchanger (NHE) Na⁺/HCO₃⁻ cotransporter (NBC) and monocarboxylate transporters (MCT) can be activated when cells are in an acidic condition (pHi < 7.1). Human radial artery smooth muscle cells (HRASMC) is an important conduit in coronary artery bypass graft surgery. However, such far, the pHi regulators have not been characterized in HRASMCs. We therefore investigated the mechanism of pHi recovery from intracellular acidosis and alkalosis, induced by NH₄Cl-prepulse and Na-acetate-prepulse, respectively, using intracellular 2',7'-bis(2-carboxethyl)-5(6)- carboxy-fluorescein (BCECF)-fluorescence in HRASMCs. Cultured HRASMCs were derived from the segments of human radial artery that were obtained from patients undergoing bypass grafting. The resting pHi is 7.22 ± 0.03 and 7.17 ± 0.02 for HEPES- (nominally HCO₃⁻-free) and CO₂/HCO₃⁻- buffered solution, respectively. In HEPES-buffered solution, a pHi recovery from induced intracellular acidosis could be blocked completely by 30 μM HOE 694 (3-methylsulfonyl-4-piperidinobenzoyl, guanidine hydrochloride) a specific NHE inhibitor, or by removing [Na⁺]₀. In 3% CO₂/HCO₃⁻-buffered solution, HOE 694 slowed the pHi recovery from the induced intracellular acidosis only, while adding together with DIDS (a specific NBC inhibitor) or removal of [Na⁺]₀ entirely inhibited the acid extrusion. Moreover, α-cyano-4-hydroxycinnamate (CHC; a specific blocker of MCT) blocked the lactate-induced pHi changes. In conclusion, we demonstrate, for the first time, that 3 different pHi regulators responsible for acid extruding, i.e. NHE and NBC, and MCT, are functionally co-existed in cultured HRASMCs.

Impact of breastfeeding self-efficacy and sociocultural factors on early breastfeeding in an urban, predominantly Dominican community.

PubMed

Glassman, Melissa E; McKearney, Karen; Saslaw, Minna; Sirota, Dana R

2014-01-01

Latinas have high breastfeeding initiation rates that decrease significantly in the first postpartum months. Little is known about the effects of self-efficacy and sociocultural factors on early breastfeeding among low-income Latinas. This study quantifies early breastfeeding rates and identifies factors associated with breastfeeding at 4-6 weeks postpartum in our community. Mothers were recruited from a newborn clinic (NBC) in the first postpartum week. Questionnaires in the NBC and 4-6 weeks later assessed feeding practices, breastfeeding self-efficacy, and sociocultural factors. Feeding practices in the well baby nursery (WBN) were obtained by chart review. A scale from "1" (exclusive formula feeding) to "5" (exclusive breastfeeding) characterized feeding practices. Paired-sample t tests assessed change in feeding practices, and regression analysis assessed the impact of factors on breastfeeding at 4-6 weeks. We interviewed 209 women: 86.1% Latina, 47.3% foreign-born, and 94.2% Medicaid-recipients. Breastfeeding increased from WBN to NBC (2.6±1.2 to 2.9±1.4; p<0.05) and then decreased by 4-6 weeks (2.9±1.4 to 2.5±1.44; p<0.05), without significant change between WBN and 4-6 weeks. Higher levels of education [β=0.21 (0.08, 0.56)], breastfeeding a previous child for ≥6 months [β=0.35 (0.57, 1.8)], foreign birth [β=0.2 (0.06, 1.07)], and higher breastfeeding self-efficacy scores [β=0.38 (0.02, 0.05)] were associated with more breastfeeding. Higher breastfeeding self-efficacy scores were associated with exclusive breastfeeding [adjusted odds ratio=1.18 (1.05, 1.32)]. Breastfeeding self-efficacy was the sole, modifiable factor associated with exclusive breastfeeding. Efforts to improve breastfeeding self-efficacy may serve to support breastfeeding in this population.

The Use of Nostalgia in Television Advertising: A Content Analysis.

ERIC Educational Resources Information Center

Unger, Lynette S.; And Others

1991-01-01

Analyzes the content of more than 1000 commercials sampled from ABC, CBS, and NBC. Finds that nostalgia was used by means of theme, copy or music about 10 percent of the time and that nostalgic references to family activities or to "olden days" were most likely to be used with food and beverage commercials. (PRA)

Documentation of Production: Allied Medical Publication 8(B), Volume 2, Medical Planning Guide of NBC Battle Casualties (Biological)

DTIC Science & Technology

2006-06-01

causing Venezuelan Equine Encephalitis (VEE). Dose Range Signs/Symptoms of Illness Category Number (organisms) Typical Description Abbreviation 1...98 Table VIII-8. Number of Infected Personnel after a Venezuelean equine encephalitis (VEE) Attack...tactical scenario, agent (anthrax, botulinum neurotoxin, plague, tularemia, Staphylococcal enterotoxin B, Q fever, Venezuelan Equine Encephalitis

Laughing Our Way to a Stronger Democracy: Political Comedy's Potential to Equalize Political Interest in Community College Students

ERIC Educational Resources Information Center

Lawrason, Lisa

2017-01-01

What effect does political comedy have on political interest? Through an experimental design, changes in political interest are measured through a pre and posttest, comparing groups randomly assigned to watch "The Daily Show," "NBC Nightly News," "Entertainment Tonight" and a no-exposure group. Models indicate…

KSC-02pd0204

NASA Image and Video Library

2002-02-24

KENNEDY SPACE CENTER, FLA. -- At opening ceremonies of the celebration of the 40th anniversary of American spaceflight, space pioneer John Glenn Jr. addresses attendees in the Rocket Garden of the KSC Visitor Complex. Behind him on the stage are (left to right) Scott Carpenter, Wally Schirra and Gordon Cooper; at right is WESH-TV (NBC) newsman Dan Billow, who served as emcee

In Search of Happier Times: Horton Foote's "The Trip to Bountiful."

ERIC Educational Resources Information Center

Novak, Glenn D.

1986-01-01

Horton Foote was among the television writers who helped make NBC's "Television Playhouse" the most popular live dramatic program on the air during the "Golden Age" of television drama, the period between 1952 and 1957. Foote felt a strong affinity for the land and people of his youth, and modeled the imaginary towns of…

Educational and Prosocial Programming on Saturday Morning Television.

ERIC Educational Resources Information Center

Calvert, Sandra L.; And Others

This study assessed the educational and informational television programming provided by four major networks, ABC, CBS, NBC, and Fox. Assessed were 29 children's television programs during the 1995-1996 season. Programs were videotaped from 7:00 a.m. to 12:00 p.m., a time frame when children are most likely to be in the viewing audience. A content…

Establishment of a Comprehensive Military Medical System during Wartime in El Salvador: A Retrospective View

DTIC Science & Technology

1988-09-01

U.S. Agency for International Development (ADSS AID/DSPE-C-0053), (April- May 1983). Books Didion , Joan . Salvador. New York: Simon and Schuster, 1983...54 Ibid, p.81. 55Joan Didion , Salvador (New York, Simon and Schuster, 1983), p.82. 56 NBC, "Whatever Happened to El Salvador?" (Circa August 1982

New FDA draft guidance on immunogenicity.

PubMed

Parenky, Ashwin; Myler, Heather; Amaravadi, Lakshmi; Bechtold-Peters, Karoline; Rosenberg, Amy; Kirshner, Susan; Quarmby, Valerie

2014-05-01

A "Late Breaking" session was held on May 20 at the 2013 American Association of Pharmaceutical Scientists-National Biotech Conference (AAPS-NBC) to discuss the US Food and Drug Administration's (FDA) 2013 draft guidance on Immunogenicity Assessment for Therapeutic Protein Products. The session was initiated by a presentation from the FDA which highlighted several key aspects of the 2013 draft guidance pertaining to immunogenicity risk, the potential impact on patient safety and product efficacy, and risk mitigation. This was followed by an open discussion on the draft guidance which enabled delegates from biopharmaceutical companies to engage the FDA on topics that had emerged from their review of the draft guidance. The multidisciplinary audience fostered an environment that was conducive to scientific discussion on a broad range of topics such as clinical impact, immune mitigation strategies, immune prediction and the role of formulation, excipients, aggregates, and degradation products in immunogenicity. This meeting report highlights several key aspects of the 2013 draft guidance together with related dialog from the session.

The Medical NBC Battlebook

DTIC Science & Technology

2000-05-01

of fever and chills within the first day postexposure is associated with a severe and life-threatening radiation dose. Hyperthermia may occur in...required at 3-5 wks for 10-50% of personnel. Anticipated problems should include infection, bleeding, and fever . Wounding or burns will geometrically...weeks, 50-100% of personnel will develop pathogenic and opportunistic infections, bleeding, fever , loss of appetite, GI ulcerations, bloody diarrhea

Iran: The Next Nuclear Threshold State?

DTIC Science & Technology

2014-09-01

than 1,000 nuclear explosives.96 Furthermore, after the Fukushima disaster , Japan shut down its reactors, but continues work on the Rakkasho...Basement,’ and China Isn’t Happy,” NBC News, March 11, 2014, http://www.nbcnews.com/storyline/ fukushima -anniversary/japan-has- nuclear - bomb-basement...line civilian nuclear program that includes enrichment and reprocessing capabilities. Japan possesses few energy resources. Before the Fukushima

Live Interviews Conducted at the 1988 GOP Convention by ABC, CBS, NBC, and CNN.

ERIC Educational Resources Information Center

Womack, David L.

To compare broadcast coverage of the 1984 and 1988 GOP Conventions, a study asked three research questions: (1) Did live interviews represent the same number of sources interviewed during broadcasts of the 1988 GOP convention by the four networks as during the 1984 convention? (2) Did 1988 live interview sources have the same distribution with…

Water resources in the Great Basin

Treesearch

Jeanne C. Chambers

2008-01-01

The Great Basin Watershed covers 362,600 km (140,110 mi2) and extends from the Sierra Nevada Range in California to the Wasatch Range in Utah, and from southeastern Oregon to southern Nevada (NBC Weather Plus Website). The region is among the driest in the nation and depends largely on winter snowfall and spring runoff for its water supply. Precipitation may be as much...

Joint Tactics, Techniques, and Procedures for Foreign Humanitarian Assistance

DTIC Science & Technology

2001-08-15

violence and nuclear, biological, or chemical (NBC) accidents). DOD policy permits military components to participate in FHA operations in response to...Acts of Man Flood, Drought, Fire, Hurricane, Earthquake Volcanic Eruption Civil Violence Nuclear, Biological, or Chemical Accidents FOREIGN DISASTERS I...Supply shortages developed, particularly of items not ordinarily required by a fighting unit — catheters for small children , for example. Finally

KSC-06pd0393

NASA Image and Video Library

2006-03-01

KENNEDY SPACE CENTER, FLA. - This aerial view of the Press Site shows the NASA TV studio (foreground), the NASA News Center behind it, buildings used by local NBC and CBS television stations, and newly erected prefabricated buildings for local newspapers and correspondents for CNN, AP and others. A year-long project removed and replaced hurricane-damaged trailers and grandstands from the site. Photo credit: Cory Huston

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (85th, Miami, Florida, August 5-8, 2002). History Division.

ERIC Educational Resources Information Center

2002

The History Division of the proceedings contains the following 13 papers: "Repositioning Radio: NBC & the 'Kitchen Radio Campaign' of 1953" (Glenda C. Williams); "The 'Poor Man's Guardian': Radicalism as a Precursor to Marxism" (Eugenie P. Almeida); "Magazine Coverage of Katharine Meyer Graham, 1963-1975" (Mary…

Dissemination of Election Returns Information: The News Election Service during Election 1980.

ERIC Educational Resources Information Center

Garrison, Bruce

In 1964, the Associated Press, ABC News, CBS News, NBC News, and United Press International formed a consortium called the News Election Service (NES) that was designed to collect one set of election returns for the entire United States. A study was made of NES operations during the presidential election year of 1980 to determine (1) the nature of…

Documentary effort.

PubMed

2006-01-01

This spring, Virtua Health, the largest health system in Southern New Jersey, launched an innovative campaign aimed at raising overall awareness of its facilities by documenting real-life patients undergoing a variety of experiences (e.g., breast cancer, high-risk pregnancy, spine surgery, and minimally-invasive knee replacement surgery). The effort, called "The Virtua Experience" became a 30-minute hospital documentary that aired on Philadelphia's NBC affiliate this summer.

The Effectiveness of the National Board Certification as It Relates to the Advanced Placement Calculus AB Exam

ERIC Educational Resources Information Center

Antunez, Fernando

2015-01-01

This study compared data related to National Board Certification (NBC) of mathematics teachers in a South Florida school district. Data included 1,162 student scores on the 2014 AP Calculus AB exam, student gender, student grade level, and eligibility for free or reduced price lunch (FRL) status. Teachers completed the Standards' Beliefs…

"The West Wing" as Endorsement of the U.S. Presidency: Expanding the Bounds of Priming in Political Communication.

ERIC Educational Resources Information Center

Holbert, R. Lance; Pillion, Owen; Tschida, David A.; Armfield, Greg G.; Kinder, Kelly; Cherry, Kristin L.; Daulton, Amy R.

2003-01-01

Uses priming as a theoretical basis to investigate potential effects of NBC's television program "The West Wing" on individual-level perceptions of the U.S. presidency among a group of undergraduate students. Finds the program primed more positive images of the U.S. Presidency that subsequently influenced individual-level perceptions. Extends…

1998 Army Modernization Plan

DTIC Science & Technology

1998-01-01

Biological (CB) Protective Duty Uniform (STO) • Biometrics (SRO) • Nanoscience (SRO) • Millimeter Wave Material and Dissemination Technology... Biometrics and Nanoscience SROs will enable the development of advanced NBC detection and characterization systems, including the exploitation of biologically...Requirements Trailers • Procure HEMAT Trailers Figure K-23 K-19 //;<?. U.S. Army 1997Modernization Plan This final fleet assessment, made against the

The Maharaja’s New AVTAAR: Air-Refuelling Strategy for the Indian Air Force

DTIC Science & Technology

2013-06-01

and Lolita C Baldor, "Boeing gets $35 Billion Air Force Tanker Order," Aviation on NBC News.com. Feruary 24, 2011. http://www.nbcnews.com/id/41766812...rakshak.com/NAVY/Ships/Active/156-Nicobar-Class.html (accessed March 23, 2013). Cassata, Donna, and Lolita C Baldor. "Boeing gets $35 Billion Air Force

Entertainment-education in a media-saturated environment: examining the impact of single and multiple exposures to breast cancer storylines on two popular medical dramas.

PubMed

Hether, Heather J; Huang, Grace C; Beck, Vicki; Murphy, Sheila T; Valente, Thomas W

2008-12-01

In the United States, entertainment-education (E-E) initiatives in primetime television that provide public health information are at risk for diminished impact due to the media-saturated environment in which they must compete. One strategy to overcome this limitation is to use multiple primetime TV shows to reinforce similar health messages in multiple storylines. The current study explores such an approach by evaluating the impact of two separate breast cancer genetics storylines featured on two different TV programs as the result of outreach to writers and producers. These storylines aired within approximately 3 weeks of each other on the popular medical dramas, ER (NBC) and Grey's Anatomy (ABC), and included information about the BRCA1 breast cancer gene mutation and the risks it poses to women who test positive for it. The evaluation used data collected from a panel sample of 599 female survey respondents at three points in time. Results show that while the individual storylines had a modest impact on viewers' knowledge, attitudes, and behaviors related to breast cancer, combined exposure seemed to be most effective at changing outcomes. Implications of our findings for future E-E interventions and evaluations are discussed.

Nuclear, Biological, Chemical (NBC) Reconnaissance Vehicles: Current Achievements and Technology Trends at SPA

DTIC Science & Technology

2004-10-25

1 Servicios y Proyectos Avanzados, S.A. (SPA) was founded in June 1991 by a small group of Spanish...permit the measurement of radiation and dangerous substances, the performance of chemical and biochemical analyses and also micro - biological...For detectors, micro -fluidics as well as hyper-spectral technologies and a whole bunch of nanotechnologies show substantial promise; they are

Chemical Vapor Synthesis of Niobium Aluminides

DTIC Science & Technology

1992-01-01

69 4.2.2 Deposition on Singly Supported Niobium Substrates ............ . . . ..... 72 4.3 DEPOSITION OF NbxSiy FROM H2, NbC15 , AND SICl4 ...direct CVD of NbxSiy from the hydrogen reduction of SiCl4 and NbCl5 is described by the overall reaction: xNbCl5 + ySiCl4 + (5x + 4y)/2 H2 - NbxSiy

Making Politics Palatable: Using Television Drama in High School Civics and Government Classes

ERIC Educational Resources Information Center

Journell, Wayne; Buchanan, Lisa Brown

2012-01-01

The authors make a case for using "The West Wing," a political drama that aired on NBC from 1999 to 2006, as an instructional tool in high school civics and government classes. The show offers a realistic portrayal of life in the White House through the eyes of Democratic President Josiah Bartlet and his senior staff that can further students'…

Low Intensity Conflict. Volume 2. Appendices.

DTIC Science & Technology

1983-06-30

parapsychology, which includes extrasensory perception (ESP). U.S. intelligence agencies, according to NBC Inc., have not taken the Soviet effort too seriously...theoreti- cal adjustment. What remains important is the perceptions of those involved concerning the implications of winning or losing. Perceotions are...opponents feel about such matters is of great concern. In 1948, over 100,000 British security forces withdrew from Palestine because of perceptions of

Assessment of Ukranian National Defense Policy

DTIC Science & Technology

2012-03-09

Romanian- Slovakian-Hungarian engineer battalion “Tisa”, as a rapid reaction force with the mission of natural disaster relief in the Carpathian region...threats (Army’s multifunctional NBC protection and engineer units) and experience of their using ( Chernobyl nuclear plant in 1986, humanitarian...man-made disasters was exemplified by the 2011 nuclear catastrophe in Japan. Moreover, based on the results of the Strategic Defense Review in Ukraine

Aspects of Tactical Biological Defense

DTIC Science & Technology

1994-06-03

physical proof of Soviet emplcyment of mycotoxins in those countries had been obtained. 30 Biochemical casualties in Laos, Kampuchea and Afghanistan...detection capability. The current system planned for use is the XM-21 Remote Sensing Chemical Agent Alarm (RSCAAL). It uses infrared sensors to detect...Micrometer(s). min. Minute(s). MS. Mans spectroscopy /mass spectrometer. NBC, Nuclear, biological and chemical. pfu. Plaque forming units--the number of

George Bush May Not Like Black People, but No One Gives a Dam about Indigenous Peoples: Visibility and Indianness after the Hurricanes

ERIC Educational Resources Information Center

King, C. Richard

2008-01-01

Shortly after the devastation of Hurricane Katrina became clear, NBC televised "A Concert for Hurricane Relief," a star-studded event watched by more than fourteen million Americans. Perhaps the most memorable moment of the evening had little to do with charity. Hip-hop artist Kanye West went "off-script" during a live segment…

Strategic Improvements to TSA Spot Program

DTIC Science & Technology

2015-03-01

Willard Shepard , “TSA Agents Rescue Kidnapped Woman,” NBC 6 South Florida. July 31, 2012, http://www.nbcmiami.com/news/local/Kidnapped-Woman-Was...For example, a high percentage of Muslims being selected by the BDOs for additional screening at a Chicago airport does not necessarily indicate...Muslim.109 Further, the traveling population from Chicago airports could have an even higher Muslim population. Local TSA

Combat Service Support Enabler Functional Assessment (CEFA). Volume 2: Individual (65) Mini-CEFA Assessments

DTIC Science & Technology

1997-12-01

SLOT) 356 57. Sensor Artificial Intelligence Communications Interactive Maintenance System (SACIMS) 361 58. Soldier’s Portable On- System Repair...increased mobility ; NBC overpressure, environmental control; and situational awareness.] 19. Related changes in CSS effectiveness. Increase The AMEV...to paragraph 17 above.] 19. Related changes in CSS effectiveness. Increase. Driver Minder alerts the maintainer about equipment and operator faults

Unit Ministry Team Essential Materiel Requirements for the Battlefield

DTIC Science & Technology

1990-03-21

School UMT Unit Ministry Team FLC Family Life Center CPE Clinical Pastoral Education BOS Battlefield Operating System NBC Nuclear, Biological...includes rites, ceremonies, sacraments, ordinances, services, pastoral care, and religious education. 5. On the battlefield, the UMT will not have the...visitations, pastoral counseling, and individual and group wor- ship experiences. During engagement or combat, the UMT’s priori- ty function shifts to

[The influence of oxygen partial pressure change and vascularization of rabbit wound through negative pressure wound therapy].

PubMed

Yang, Fan; Hu, Duan; Bai, Xiang-jun; Zhang, Kun; Li, Ren-jie; Xue, Chen-chen

2012-07-01

To investigate the effect of vacuum sealing drainage (VSD) on variation of oxygen partial pressure (PtO2) and vascularization. The 12 cases of rabbit's wound models were undergoing the VSD (vacuum group, n = 6) or conventional therapy (conventional group, n = 6). Variation of PtO2 was measured by oxygen partial pressure admeasuring apparatus, expression of hypoxia inducible factor 1α (HIF-1α) mRNA was measured by real-time fluorescent quantitative PCR, content of vascular endothelial growth factor (VEGF) was measured by ELISA after tissue homogenate in 7 days. Vascular endothelial cell (VEC) and new blood capillary (NBC) of hematoxylin-eosin slice of tissue were counted by using light microscope. Average value of PtO2 of vacuum group was significant lower than conventional group (t = -99.780 to -5.305, P < 0.01). Expression of HIF-1α (30 minutes, 1, 6, 12 hours were 3.11 ± 0.07, 3.68 ± 0.26, 4.16 ± 0.13 and 3.91 ± 0.26 respectively) and content of VEGF (30 minutes, 1, 6, 12 hours were 103.3 ± 2.4, 134.2 ± 9.0, 167.8 ± 3.8 and 232.1 ± 9.5 respectively) of vacuum group were increased after 30 minutes and significant lower than conventional group (t = 13.038 - 80.208, P < 0.01), and both of them were reduced after 24 hours (P < 0.05). Counting numbers of VEC (2.47 ± 0.45 to 4.70 ± 0.38) and NBC (1.33 ± 0.49 to 4.33 ± 0.68) of vacuum group were increased at the same time-point and significant higher than conventional group (t = -0.670 to 16.500, P < 0.05). PtO2 of wound surface could be reduced significantly by VSD. Expression of HIF-1α and content of VEGF were increased by VSD for enhancing differentiated state of VEC and construction of NBC, which were better for vascularization and wound healing.

Microstructural evolution in the HAZ of Inconel 718 and correlation with the hot ductility test

NASA Technical Reports Server (NTRS)

Thompson, R. G.; Genculu, S.

1983-01-01

The nickel-base alloy 718 was evaluated to study the role of preweld heat treatment in reducing or eliminating heat-affected zone hot cracking. Three heat treatments were studied using the Gleeble hot ductility test. A modified hot ductility test was also used to follow the evolution of microstructure during simulated welding thermal cycles. The microstructural evolution was correlated with the hot ductility data in order to evaluate the mechanism of hot cracking in alloy 718. The correlation of hot ductility with microstructure showed that recrystallization, grain growth, and dissolution of precipitates did not in themselves cause any loss of ductility during cooling. Ductility loss during cooling was not initiated until the constitutional liquation of NbC particles was observed in the microstructure. Laves-type phases were found precipitated in the solidified grain boundaries but were not found to correlate with any ductility loss parameter. Mechanisms are reviewed which help to explain how heat treatment controls the hot crack susceptibility of alloy 718 as measured in the hot ductility test.

Combating WMD Journal. Issue 1

DTIC Science & Technology

2007-01-01

Design /Layout CW5 Stephen A. Gomes Ms. Helen M. Stewart DISTRIBUTION STATEMENtI A Approved for Public Release Distribution Unlimited FRO THE DIECO...forming to assist Echelon Above Corps Army elements NBC Defence Factors in the Design , Testing and Accep- with CWMD planning capability. Their initial...Counterproliferation (CP) and Con- with smaller number of officers (-160 designers of the current Officer Pro- sequence Management (CM) arenas FA52s and 275 EOD

Israel: Strategic Asset or Strategic Liability?

DTIC Science & Technology

2013-04-23

Martin Fletcher, an NBC News correspondent, with a Palestinian man in Ramallah, Israel. During the interview, Mustafa al Khteeb says, “I cannot feed my...Kilometers Petra Qunaltlra Syria Az-Zarqa . • Jordan AI Karak CJ - Arab State/Palestine Jewish State{Israel Corpus Separatum/ Jerusalem BASED...and Walt, The Israel Lobby and U.S. Foreign Policy, 53. 129 Ibid., 53-4. 130 Ibid., 54. 131 Martin Fletcher, “Not Welcome: Disappointment Greets

Evaporation from Sand

DTIC Science & Technology

1992-04-01

Instituuts Advies R2ad PML Prof. dr. U.A.Th. Brinkanl~ 36. Direactur van het Medisch Biologisch Laboratorium TNO Prof.Dr. W.R.F. Notten 37. Directeur...Grootsdialige Rampenbestrijdcing Ministerie van Binnenlandsc Zaken Drs. H. Evers 9. Adviseur van het Prins Maurits Laboratorium TWO Prot. Dr. J.M. van...Rossum, 10. Adyisew, van het Prins Maurits Laboratorium TWO Chernisdie Research Prof.Dr. G. Dijkstra 11. H~ur. NBC DMKIJOMAT/KIO Ir. AAM. Slagveer 12

Transnational Threats: Blending Law Enforcement and Military Strategies

DTIC Science & Technology

2000-11-01

Providing Humanitarian Assistance Following NBC Accidents/Incidents: The Legal Considerations, Colorado Springs, CO: Institute for National Security Studies...draft of a position on cyber crime .36 The draft focused on such issues as extradition, mutual legal assistance, and trans-border computer searches. These...warfare also raises specific legal issues related to computer crime : what is a crime , who commits it, and what does the law say about it? 21. A

NBC Hazard Prediction Model Capability Analysis

DTIC Science & Technology

1999-09-01

tactical units surveyed, only the 82nd Airborne Division indicated any real experience with either model. The tactical units surveyed did use some form...Tracer Experiment (1987) and ETEX =European Tracer Experiment (1994). 22 These data sets include Phase I Dugway data, the Prairie Grass data set...I 8 hr) HPAC Different scales shown swru. Doll ~ (1.ean) Tolll GD 111:3-Stp-88 2J:OOL (I.DOin) ... 1 .... .... ... ..... ,l

Technology Base Seminar Wargame 2 (TBSWG 2). Volume 1. Summary Report

DTIC Science & Technology

1990-11-16

nuclear, biological and chemical (NBC) and ballistic protection without reducing soldier mobility . Training and rehearsal systems will allow the...7 KNOW WHERE THE ENEMY IS ALL THE TIME SENSOR FIDEUTY INFORMATION FUSION 3 RANGE OF COMMO 4 RANGE OF FIRES S PRECISION MUNITIONS 6 RAPID MOBILITY 7...and .nfo Precision Problems and TECNOLOGIES Fusion) Fires Mobility Advanced Materials/ Material Processing 0) Advanced Propulsion Advanced Signal

Stochastic flow shop scheduling of overlapping jobs on tandem machines in application to optimizing the US Army's deliberate nuclear, biological, and chemical decontamination process, (final report). Master's thesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Novikov, V.

1991-05-01

The U.S. Army's detailed equipment decontamination process is a stochastic flow shop which has N independent non-identical jobs (vehicles) which have overlapping processing times. This flow shop consists of up to six non-identical machines (stations). With the exception of one station, the processing times of the jobs are random variables. Based on an analysis of the processing times, the jobs for the 56 Army heavy division companies were scheduled according to the best shortest expected processing time - longest expected processing time (SEPT-LEPT) sequence. To assist in this scheduling the Gap Comparison Heuristic was developed to select the best SEPT-LEPTmore » schedule. This schedule was then used in balancing the detailed equipment decon line in order to find the best possible site configuration subject to several constraints. The detailed troop decon line, in which all jobs are independent and identically distributed, was then balanced. Lastly, an NBC decon optimization computer program was developed using the scheduling and line balancing results. This program serves as a prototype module for the ANBACIS automated NBC decision support system.... Decontamination, Stochastic flow shop, Scheduling, Stochastic scheduling, Minimization of the makespan, SEPT-LEPT Sequences, Flow shop line balancing, ANBACIS.« less

Energy for the interface system of (Nb, Mo)C/γ-Fe

NASA Astrophysics Data System (ADS)

Zhou, Yanyuan; Wang, Zhenqiang; Zhao, Jiaying; Leng, Zhe; Niu, Zhongyi; Guo, Chunhuan; Zhang, Zhengyan; Yang, Zhigang; Yao, Chunfa; Jiang, Fengchun

2017-08-01

The interfacial energies of MC/γ-Fe and formation energies of MC carbides have been investigated using first-principles calculations based on density functional theory (DFT). Results show that the replacement of Nb by Mo in the NbC lattice is unfavorable with respect to the formation energy. However, it reduces the lattice parameter of MC and decreases the σ_{{chemical}} (interfacial chemical energy) of MC/γ-Fe, thus favoring the formation of complex (Nb, Mo)C carbide. The substitution of Nb by Mo at the interface of MC/γ-Fe system promotes the hybridizations of Mo-1NNFe and C-1NNFe (or 2NNFe) (the first or second nearest neighboring Fe atoms), which leads to a decrease in σ_{{chemical}}. The influence of bond energy is estimated using the discrete lattice plane/nearest neighbor broken bond (DLP/NNBB) model. It is found that the reduced σ_{{chemical}} is attributed to the much smaller value of e_{{{{Fe-C}}}} - e_{{{{Mo-C}}}} (the difference between Fe-C and Mo-C interactions) compared to e_{{{{Fe-C}}}} - e_{{{{Nb-C}}}} (the difference between Fe-C and Nb-C interactions). The results obtained from the analysis of the precipitates in Nb- and Nb-Mo-bearing steels are in a good agreement with the calculations.

Tensile strength and creep behaviour of austenitic stainless steel type 18Cr - 12Ni with niobium additions at 700°C

NASA Astrophysics Data System (ADS)

Sordi, V. L.; Bueno, L. O.

2010-07-01

The effect of niobium additions up to 2.36 wt% on the creep behavior of a series of seven extra low carbon 18Cr-12Ni austenitic stainless steels at 700°C has been investigated. Grain size and hardness measurements, hot tensile tests and constant stress creep tests from 90 to 180 MPa were carried out for each alloy, in the solution treated condition at 1050, 1200 and 1300°C followed by quench in water. The mechanical behavior at high temperature was related to the amount of NbC precipitation occurring during the tests. Solid solution and intermetallic compound effects were also considered. Creep data analysis was done to determine the parameters of the creep power-law equation dot epsilon = A.σn and the Monkman-Grant relation dot epsilon.tmR = K. Niobium-carbide precipitation in these steels reduces the secondary stage dependence of strain rate with applied stress, resulting in n-values which indicate the possibility of operation of various creep mechanisms. The creep strength during the secondary stage is primarily controlled by the amount of NbC available for precipitation. However, the rupture times increase progressively with niobium content, as the amount of undissolved carbide particles in grain boundaries and the Laves phase precipitation increase.

NATO Handbook on the Medical Aspects of NBC Defensive Operations AMedP-6(B)

DTIC Science & Technology

1996-02-01

contaminated aerosols, ingest raw (unpasteurized) infected milk or meat, or have abraded skin or conjunctival surfaces that come in contact with the...Syndrome. (1) Characteristics. Rift Valley Fever ( RVF ) is a viral disease caused by RVF virus. The virus circulates in sub-Saharan Africa as a...characteristic of RVF . (2) Routine Laboratory Findings. In acute uncomplicated disease, there is often a transient leucopenia, but liver and clotting

Rethinking the Unthinkable: Selective Proliferation and US Nuclear Strategy

DTIC Science & Technology

2011-06-01

Equally commendable are the efforts of the SAASS librarian Sandhya "Sandy" Malladi and the SAASS secretaries Sheila McKitt and Kelly Rhodes. These...Nuclear Deterrence and Global Security in Transition, 177. 20 Barry R . Schneider, Future War and Counterproliferation: US Military Responses to Nbc...develop states prepared to conduct themselves as nuclear weapons 42 Barre R . Seguin, "Why Did Poland Choose the F-16?," The Marshall Center

Effects of Heat Acclimation on Heat-Exercise Tolerance in Untrained and Endurance-Trained Men Wearing NBC Protective Clothing

DTIC Science & Technology

1993-08-01

2-1 + 273.15]’.(A.A"•1 ) (Eq. 5) h. = 23.4.v,.ŗ" (Eq. 6) in which a is the Stefan -Boltzmann constant (20.4-10-8 UNCLASSIFIED 8 UNCLASSIFIED kJ-m-’-h...Vallerand AL, Limmer R, Schmegner IF (1989) Computer acquisition and analysis of skin temperature and heat flow data from heat flux transducers. Computer

INTERMEDIATE STAGES OF REACTIONS FORMING CARBIDES OF TITANIUM, ZIRCONIUM, VANADIUM, NIOBIUM, AND TANTALIUM

DTIC Science & Technology

Tensimetric examination was made of the formation of the carbides TiC , ZrC, VC, NbC and TaC in a vacuum. During x-ray and chemical analysis of...for obtaining TiC , and ZrC through the stage of intermediate oxides Ti2O3, Ti3O5, TiO and Zr2O3, ZrO, respectively and also for the reaction of

Integrating SIMNET into Heavy Task Force Tactical Training

DTIC Science & Technology

1994-10-01

the overlays will allow the battlemaster time to input them for display on the Plan View Display ( PVD ) for use in AARs. The time schedule must also...reconnaissance for both friendly and enemy forces to occupy. The stealth station, in conjunction with the Plan View Display ( PVD ), can be used to...was moved to another assembly area for armor crewman and Nuclear, Biological, and Chemical (NBC) skills testing. The battalion observer tested 25% to

Analysis of Ductile-Brittle Transition Temperatures for Controlled-Rolled, Microalloyed, C-Mn Based Steels.

DTIC Science & Technology

1988-05-01

This deformation gives an increase in friction stress without much further reduction in grain size. Solid solution and precipitation strengthening are...finishing temperatures because of the measured effect of Mo on lowering the ferrite transformation temperature (I). The precipitation of NbC in the...unchanged. Very probably, Mo, through its solid solution strengthening of ferrite, particularly at 760°C in the austenite-ferrite region, caused the

Development of an Integrated Toxicity Assessment System for use in Operational Deployment and Materials Development

DTIC Science & Technology

2006-05-01

In addition to NBC concerns, there are issues in many current military settings for exposures to toxic industrial chemicals or materials (TICs or TIMs...Significant health issues caused by use of legacy chemicals have emphasized the need for more effective predication of chemical toxicity . This paper...current military settings for exposures to toxic industrial chemicals or materials (TICs or TIMs). Significant health issues caused by use of legacy

Nuclear and NBC Contamination Survivability of Medical Materiel

DTIC Science & Technology

1990-03-01

protection devices employed at the equipment signal and power interfaces. 4.2.5.7 (4.x.3) Netronlg.ence - The equipment shall be exposed in such a...hardening approaches shall account for the equipment being passive (i.e., de-energized) as well as being powered (i.e., energized), and shall account for...components used. In addition, electronic systems may exhibit different D-6 vulnerabilities depending on whether the power is on or off, and whether

Report on Activities and Programs for Countering Proliferation and NBC Terrorism. Volume 1. Executive Summary

DTIC Science & Technology

2011-05-01

Homeland Security (DHS) and the Department of State (DOS), and by changing the IC’s CPRC representative from the Director of Central Intelli- gence to the...Security Strategy of the United States of America (May 2010), p. 4. 2 Nuclear Posture Review Report (April 6, 2010), p. i 3 National Strategy for...ongoing efforts with GICNT, the Nuclear Forensics International Technical Working Group (ITWG), Forensics En - gagement Working Group (FEWG), NATO

TV report on DTP galvanizes US pediatricians.

PubMed

González, E R

1982-07-02

An NBC television documentary on the risks of the diphtheria-pertussis-tetanus (DPT) vaccine, aired in April 1982, alarmed parents and elicited criticism from physicians that the program was biased. This article discussed the controversial broadcast, the incidence and risks of whooping cough (pertussis), and the contraindications to receiving the pertussis component of the DPT vaccine. Conflicting reports on the numbers of American and British children damaged by the shots, and physicians' attitudes for and against DPT immunization, are examined.

Effectiveness and Acceptability of Nutrient Solutions in Enhancing Fluid Intake in the Heat

DTIC Science & Technology

1988-11-18

water Placebo - colored, flavored, artificially sweetened solution TEST BEVERAGE - NBC Nutrient Solution Water Other fluids 2.5% fructose...Q) •H fa ACCEPTABILITY OF TEST BEVERAGES control (no natural or artificial sweetener added) with subjects exercised at 400 watts in a climatic...ever drunk beverages with "Nutrasweet" Sweetener in them? ) Yes )No (skip to question 27) |Don’t know (skip to question 27) Page 4 196 o 5590

KSC-06pd0394

NASA Image and Video Library

2006-03-01

KENNEDY SPACE CENTER, FLA. - This aerial view shows the Press Site (in the foreground) comprising the NASA TV studio, the NASA News Center behind it, buildings used by local NBC and CBS television stations, and newly erected prefabricated buildings for local newspapers and correspondents for CNN, AP and others. A year-long project removed and replaced hurricane-hazardous trailers and bleachers from the site. In the background, at right, is the newly build Operations Support Building II. Photo credit: Cory Huston

Estimating the Manpower, Personnel, and Training Requirements of the Army’s Corps Support Weapon System Using the HARDMAN Methodology

DTIC Science & Technology

1982-09-01

Description 24 3-4 System Analysis 26 3-5 CSWS Fire Control System 40 3-6 Hybrid Collective Protection Equipment 46 4-1 Macrit Calculation 50 4-2...suppression. The U.S. Army Chemical Laboratory, Aberdeen Proving Grounds, is developing hybrid collective protection equipment (HCPE) to provide NBC...Washington, DC: Department of the Army, 15 January 1981. Hybrid collective protection equipment (HCPE) application guidelines. Clearwater, FL

Navy Verbal Skills Curriculum Guide. Supplement.

DTIC Science & Technology

1982-07-01

you name? 1. CIA - 2. TV - 3. NBC - 4. CB - 5. TB - 6. FBI - 7. USC - S. RN - 9. NFL - 10. PA - 11. NBA - 12. ABC - 13. GOP - 14. US - 15. mph - 16...Deposit 11. National Basketball Association 23. prisoner of war 12. American Broadcasting Corporation Prescription Worksheet 4 See Bluejackets’ Manual...1. What is your favorite sport? include? 2. What is your favorite (foot- 2. What type of skills are you ball, baseball, basketball ) learning? team? 3

Dynamic and scalable audio classification by collective network of binary classifiers framework: an evolutionary approach.

PubMed

Kiranyaz, Serkan; Mäkinen, Toni; Gabbouj, Moncef

2012-10-01

In this paper, we propose a novel framework based on a collective network of evolutionary binary classifiers (CNBC) to address the problems of feature and class scalability. The main goal of the proposed framework is to achieve a high classification performance over dynamic audio and video repositories. The proposed framework adopts a "Divide and Conquer" approach in which an individual network of binary classifiers (NBC) is allocated to discriminate each audio class. An evolutionary search is applied to find the best binary classifier in each NBC with respect to a given criterion. Through the incremental evolution sessions, the CNBC framework can dynamically adapt to each new incoming class or feature set without resorting to a full-scale re-training or re-configuration. Therefore, the CNBC framework is particularly designed for dynamically varying databases where no conventional static classifiers can adapt to such changes. In short, it is entirely a novel topology, an unprecedented approach for dynamic, content/data adaptive and scalable audio classification. A large set of audio features can be effectively used in the framework, where the CNBCs make appropriate selections and combinations so as to achieve the highest discrimination among individual audio classes. Experiments demonstrate a high classification accuracy (above 90%) and efficiency of the proposed framework over large and dynamic audio databases. Copyright © 2012 Elsevier Ltd. All rights reserved.

LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients

PubMed Central

Duzkale, Hatice; Schweighofer, Carmen D.; Coombes, Kevin R.; Barron, Lynn L.; Ferrajoli, Alessandra; O'Brien, Susan; Wierda, William G.; Pfeifer, John; Majewski, Tadeusz; Czerniak, Bogdan A.; Jorgensen, Jeffrey L.; Medeiros, L. Jeffrey; Freireich, Emil J; Keating, Michael J.

2011-01-01

We previously identified LDOC1 as one of the most significantly differentially expressed genes in untreated chronic lymphocytic leukemia (CLL) patients with respect to the somatic mutation status of the immunoglobulin heavy-chain variable region genes. However, little is known about the normal function of LDOC1, its contribution to the pathophysiology of CLL, or its prognostic significance. In this study, we have investigated LDOC1 mRNA expression in a large cohort of untreated CLL patients, as well as in normal peripheral blood B-cell (NBC) subsets and primary B-cell lymphoma samples. We have confirmed that LDOC1 is dramatically down-regulated in mutated CLL cases compared with unmutated cases, and have identified a new splice variant, LDOC1S. We show that LDOC1 is expressed in NBC subsets (naive > memory), suggesting that it may play a role in normal B-cell development. It is also expressed in primary B-cell lymphoma samples, in which its expression is associated with somatic mutation status. In CLL, we show that high levels of LDOC1 correlate with biomarkers of poor prognosis, including cytogenetic markers, unmutated somatic mutation status, and ZAP70 expression. Finally, we demonstrate that LDOC1 mRNA expression is an excellent predictor of overall survival in untreated CLL patients. PMID:21310924

On the Squeezing of the North Brazil Current Rings Through the Lesser Antilles as Observed From Satellite Data

NASA Astrophysics Data System (ADS)

Bulgakov, S. N.; Cruz Gomez, R. C.

2007-05-01

The North Brazil Current Rings (NBCR) penetration into the Caribbean Sea is being investigated employing a merged altimeter-derived sea height anomaly (TOPEX/Poseidon, Jason-1 and ERS-1,2), the ocean surface color data (SeaWiFS) and Global Drifter Program information. Four strategies are being applied to process the data: (1) calculations of Okubo-Weiss parameter for NBCR identification, (2) longitude-time plots (also known as Hovmöller diagrams), (3) two-dimensional Radon transforms and (4) two-dimensional Fourier transforms. A twofold NBCR structure has been detected in the region under investigation. The results have shown that NBC rings mainly propagate into the Caribbean Sea along two principal pathways (near 12ºN and 17ºN) in the ring translation corridor. Thus, rings following the southern pathway in the fall-winter period can enter through very shallow southern straits as non-coherent structures. A different behavior is observed near the northern pathway (near 17ºN), where NBC rings are thought to have a coherent structure during their squeezing into the eastern Caribbean, i.e. conserving the principal characteristics of the incident rings. We attribute this difference in the rings' behavior to the vertical scales of the rings and to the bottom topography features in the vicinity of the Lesser Antilles.

Organic Composite Applications for the M1/M1A1

DTIC Science & Technology

1986-07-01

250 seconds for ten flame applications 3. ignite dry coton placed 12 inches below the specimen 4. have glowing combustion for more than 60 seconds after...have some effects on these materials. Since these effects have not been completely defined due to the "state of the art," all finished products should...rework and post- finishing which results in coat savings. -67- Table 5-7. N.B.C. Compatibility with Composite and Plastic Materials Material Relative

Efficacy of Liquid, Air, and Phase Change Material Torso Cooling During Light Exercise While Wearing NBC Clothing

DTIC Science & Technology

1998-03-01

and Thermal Comfort 6 Blood Sampling 6 Statistical Analyses 6 RESULTS 7 Indices of Hydration Status 7 Liquid-Cooling and PCM Cooling Vests...of Uncooled Sites 12 Vapour Pressure 12 Ratings of Thermal Comfort and Perceived Exertion 18 Indices of Heat Tolerance 18 DISCUSSION 20...ill Figures 8A and B Changes in ratings of thermal comfort of the torso and whole body during light exercise at 40°C and 30% relative humidity while

Effects of A NBC (Nuclear, Biological, and Chemical) Nutrient Solution on Physiological and Psychological Status during Sustained Activity in the Heat

DTIC Science & Technology

1987-07-17

of sugar (3). Kety (14) reported that a significant decrease in the blood glucose level is consistently associated with manifestations of impaired...Brozek J, Keys A. Relationship of speed of motor reaction to blood sugar level during acute starvation in man, abstracted. Fed Proc 1945;4:28. 9. Blom...profound low blood sugar can cause irreversible brain damage (21,30). Since hypoglycemia did not develop, it was not possible to assess the effects of

Al Roker Interview with NASA for GOES-R Mission

NASA Image and Video Library

2016-11-19

During the countdown for the launch of NOAA's Geostationary Operational Environmental Satellite, or GOES-R, Stephanie Martin of NASA Communications, right, interviews Al Roker, weather forecaster on NBC's "Today Show." GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

Al Roker Interview with NASA for GOES-R Mission

NASA Image and Video Library

2016-11-19

During the countdown for the launch of NOAA's Geostationary Operational Environmental Satellite, or GOES-R, Stephanie Martin of NASA Communications, left, interviews Al Roker, weather forecaster on NBC's "Today Show." GOES-R is the first satellite in a series of next-generation GOES satellites for NOAA, the National Oceanographic and Atmospheric Administration. It will launch to a geostationary orbit over the western hemisphere to provide images of storms and help meteorologists predict severe weather conditionals and develop long-range forecasts.

Combined Annual Report to Congress on Standardization of Equipment with NATO Members and Cooperative Research and Development Projects with Allied Countries

DTIC Science & Technology

1990-06-01

Contamination Marking Set This set is designed for marking areas contaminated with nuclear, biological and chemical (NBC) agents. It consists of a metal ...program, formerly the Heavy Forces Modernization (HFM) program. In March 1990, the Army Systems Acquisition Review Council (ASARC) reviewed the ASM...AUTOKO) prior to initial fielding of MSE in Europe this year, interoperability training was conducted at Grafenwoehr , Germany, from 30 January to 1

Marine Corps NBC Warfare: Determining Clinical Supply Requirements for Treatment of Battlefield Casualties from Chemical and Biological Warfare

DTIC Science & Technology

2003-05-01

medical supply blocks. Two available botulism antitoxins—the Centers for Disease Control and Prevention (CDC) trivalent equine antitoxin for serotypes...4th Ed. Fort Detrick, MD. U.S. Army Medical Research Institute of Infectious Diseases ; 2001: 9-12. 3. Sidell, FR, Franz, David R. Overview: Defense...Diagnosis and Treatment of Diseases of Tactical Importance to U.S. Central Command. Aberdeen Proving Ground, MD: U.S. Army Center for Health Promotion and

The Road To The Objective Force. Armaments for the Army Transformation

DTIC Science & Technology

2001-06-18

Vehicle Fire Support Vehicle •TOW 2B Anti-Tank Capability Under Armor •Detection of NBC Hazards Mortar Carrier •Dismounted M121 120mm MRT Initially...engaged from under armor M6 Launchers (x4) Staring Array Thermal Sight Height reduction for air transport Day Camera Target Acq Sight Armament Remote...PM BCT ANTI-TANK GUIDED MISSILE VEHICLE • TOWII • ITAS (Raytheon) - 2 Missiles • IBAS Day Camera • Missile is Remotely Fired Under Armor • M6 Smoke

The Effects of US Army Chemical Protective Clothing on Speech Intelligibility, Visual Field, Body Mobility and Psychomotor Coordination of Men

DTIC Science & Technology

1987-09-01

soldiers wearing NBC clothing in hot/humid and hot/dry climates (Report MRL-R-826).Ascot Vale, Victoria, Australia : Materials Research Laboratories...Development and Engineering Center. 47. White, R.M. and Churchill, E. (1971). The body size of soldier-: U.S. Army anthropometry - 1966 (Tech. Rep. 72... Anthropometry of U.S. Army aviators - 1970 (Tech. Rep. 72-52-CE). Natick, MA: US Army Natick Laboratories. (AD 743 528) 112 ,7 r4 r

Low-temperature electrical resistivity of transition-metal carbides

NASA Astrophysics Data System (ADS)

Allison, C. Y.; Finch, C. B.; Foegelle, M. D.; Modine, F. A.

1988-10-01

The electrical resistivities of single crystals of ZrC 0.93, VC 0.88, NbC 0.95, and TaC 0.99 were measured from liquid helium temperature to 350 K. The Bloch-Gruneisen theory of electrical resistivity gives a good fit to the zirconium carbide and the vanadium carbide measurements. In contrast, the resistivities of the two superconducting crystals, tantalum carbide and niobium carbide, show excellent agreement with the Wilson model. The appropriate model appears to depend upon the superconducting properties of the crystals.

Review of Rover fuel element protective coating development at Los Alamos

NASA Technical Reports Server (NTRS)

Wallace, Terry C.

1991-01-01

The Los Alamos Scientific Laboratory (LASL) entered the nuclear propulsion field in 1955 and began work on all aspects of a nuclear propulsion program with a target exhaust temperature of about 2750 K. A very extensive chemical vapor deposition coating technology for preventing catastrophic corrosion of reactor core components by the high temperature, high pressure hydrogen propellant gas was developed. Over the 17-year term of the program, more than 50,000 fuel elements were coated and evaluated. Advances in performance were achieved only through closely coupled interaction between the developing fuel element fabrication and protective coating technologies. The endurance of fuel elements in high temperature, high pressure hydrogen environment increased from several minutes at 2000 K exit gas temperature to 2 hours at 2440 K exit gas temperature in a reactor test and 10 hours at 2350 K exit gas temperature in a hot gas test. The purpose of this paper is to highlight the rationale for selection of coating materials used (NbC and ZrC), identify critical fuel element-coat interactions that had to be modified to increase system performance, and review the evolution of protective coating technology.

Dietary nitrate reduces the O2 cost of desert marching but elevates the rise in core temperature.

PubMed

Kuennen, Matthew; Jansen, Lisa; Gillum, Trevor; Granados, Jorge; Castillo, Weston; Nabiyar, Ahmad; Christmas, Kevin

2015-12-01

Dietary nitrate (NO3 (-)) supplementation reduces the O2 cost of fixed-workload tasks performed in temperate environments but has not been examined in the heat. If this effect were retained it could reduce heatstroke risk in military personnel that are deployed for desert combat. Nine men completed three 45 min loaded battle marches at a standard cadence (4.83 km h(-1)/1.5 % grade) while wearing full combat gear [BDU, boots, body armor (8 kg), NBC suit] and carrying a loaded rucksack (16 kg). The 1st March (FAM) commenced in a temperate environment. The 2nd and 3rd commenced in simulated dry desert conditions (41 °C/20 % RH) and required subjects to ingest the beetroot juice equivalent of 8.4 mmol NO3 (-) (BRJ) or a NO3 (-) depleted placebo (PLA) for 6 days prior. VO2, VCO2, V E, core (T re), skin (T sk), and mean body (T b) temperatures, HR, and physiological strain index (PSI) were measured continuously. Thermal sensation, generalized discomfort, and perceived exertion (RPE) were measured at 5 min intervals. Heat storage (HS) was calculated. Blood markers of gastrointestinal permeability (TNF, Il-6, HO-1) were measured before and after exercise. VO2 in BRJ was lower than PLA from 1 to 12; 16 to 26; and 29 to 45 min of exercise (p < 0.05). VCO2 in BRJ was lower than PLA from 1 to 12 min (p < 0.05). V E in BRJ was lower than PLA from 1 to 20 min of exercise (p < 0.05). T re and T b in BRJ exceeded PLA from 16 to 45 min (p < 0.05). TNF, Il-6, and HO-1 were reduced in BRJ (p < 0.05) while HR, PSI, Tsk, and HS were not altered (p > 0.05). Thermal sensation, generalized discomfort, and RPE were elevated in BRJ from 40 to 45, 25 to 45, and 10 to 45 min, respectively (p < 0.01). Metabolic efficiency was improved in BRJ. Paradoxically, body temperatures rose more. This was not due to gut permeability. Therefore, we speculate that based on elimination of other possibilities, blood redistribution from skin to skeletal muscle may have contributed to impaired heat exchange.

Small-scale effects of thermal inflation on halo abundance at high-z, galaxy substructure abundance, and 21-cm power spectrum

NASA Astrophysics Data System (ADS)

Hong, Sungwook E.; Zoe, Heeseung; Ahn, Kyungjin

2017-11-01

We study the impact of thermal inflation on the formation of cosmological structures and present astrophysical observables which can be used to constrain and possibly probe the thermal inflation scenario. These are dark matter halo abundance at high redshifts, satellite galaxy abundance in the Milky Way, and fluctuation in the 21-cm radiation background before the epoch of reionization. The thermal inflation scenario leaves a characteristic signature on the matter power spectrum by boosting the amplitude at a specific wave number determined by the number of e-foldings during thermal inflation (N_{bc}), and strongly suppressing the amplitude for modes at smaller scales. For a reasonable range of parameter space, one of the consequences is the suppression of minihalo formation at high redshifts and that of satellite galaxies in the Milky Way. While this effect is substantial, it is degenerate with other cosmological or astrophysical effects. The power spectrum of the 21-cm background probes this impact more directly, and its observation may be the best way to constrain the thermal inflation scenario due to the characteristic signature in the power spectrum. The Square Kilometre Array (SKA) in phase 1 (SKA1) has sensitivity large enough to achieve this goal for models with N_{bc} ≳ 26 if a 10000-hr observation is performed. The final phase SKA, with anticipated sensitivity about an order of magnitude higher, seems more promising and will cover a wider parameter space.

In the 25th year of bioethics publishing: new challenges of the post-truth era.

PubMed

Jesani, Amar

2017-01-01

As IJME enters its 25th year of publication, all of us closely associated with the journal look back on this journey with a degree of satisfaction. Not only has the only bioethics journal published from India survived for 24 years, it has also produced some extraordinary successes. As you read this issue, we will be celebrating the 12th year of the biennial National Bioethics Conferences - the sixth NBC will take place in Pune from January 13 to 15, 2017.

ARC-2006-ACD06-0179-002

NASA Image and Video Library

2006-10-12

Ames holds a Media Day at the Hypervelocity Free Flight facility where Ames is conducting high-speed tests of small models of the agency's new Orion CEV to learn about stability during flight. The hypervelocity test facility uses a gun to shoot Orion models between 0.5 and l.5 inches (1.25 - 3.75 centimeters in diameter. The facility can conduct experiments with speeds up to 19,000 miles per hour (30,400 kilometers per hour) - NBC Channel 11 Technology/Business reporter Scott Budman at the gun range (w/C Acosta in bkgrd)

KSC-06pd0395

NASA Image and Video Library

2006-03-01

KENNEDY SPACE CENTER, FLA. - This aerial view shows the Press Site (in the foreground) comprising the NASA TV studio, the NASA News Center behind it, buildings used by local NBC and CBS television stations, and newly erected prefabricated buildings for local newspapers and correspondents for CNN, AP and others. A year-long project removed and replaced hurricane-damaged trailers and grandstands from the site. In the background, at right, is the newly built Operations Support Building II, which replaced modular housing and trailers in the Launch Complex 39 area. Photo credit: Cory Huston

What is that mysterious booming sound?

USGS Publications Warehouse

Hill, David P.

2011-01-01

The residents of coastal North Carolina are occasionally treated to sequences of booming sounds of unknown origin. The sounds are often energetic enough to rattle windows and doors. A recent sequence occurred in early January 2011 during clear weather with no evidence of local thunder storms. Queries by a local reporter (Colin Hackman of the NBC affiliate WETC in Wilmington, North Carolina, personal communication 2011) seemed to eliminate common anthropogenic sources such as sonic booms or quarry blasts. So the commonly asked question, “What's making these booming sounds?” remained (and remains) unanswered.

Low resistance barrier layer for isolating, adhering, and passivating copper metal in semiconductor fabrication

DOEpatents

Weihs, Timothy P.; Barbee, Jr., Troy W.

2002-01-01

Cubic or metastable cubic refractory metal carbides act as barrier layers to isolate, adhere, and passivate copper in semiconductor fabrication. One or more barrier layers of the metal carbide are deposited in conjunction with copper metallizations to form a multilayer characterized by a cubic crystal structure with a strong (100) texture. Suitable barrier layer materials include refractory transition metal carbides such as vanadium carbide (VC), niobium carbide (NbC), tantalum carbide (TaC), chromium carbide (Cr.sub.3 C.sub.2), tungsten carbide (WC), and molybdenum carbide (MoC).

The German Debate Over Military Peacekeeping Missions: The First Step Toward an Eventual Combat Role

DTIC Science & Technology

1993-12-01

3Clay Clemens , "Opportunity or Obligation? Redefining Germany’s Military Role Outside of NATO," in Armed Forces and Soci&L, vol. 19, No. 2, Winter 1993, p...ranged from 79 fuchs NBC detection vehi-les, an excess of 315,000 rounds of tank and artillery ammunition, 2,000 radio sets, 600 shower-bath vehicles...Tale," p. 96. ’ 59Ibid., p. 92. The three activists were Franz Josef Strauss (CSU) from 1956 to 1962, Helmut Schmidt (SPD) from 1969 to 1972 and Manfred

A mathematical model of the pancreatic duct cell generating high bicarbonate concentrations in pancreatic juice.

PubMed

Whitcomb, David C; Ermentrout, G Bard

2004-08-01

To develop a simple, physiologically based mathematical model of pancreatic duct cell secretion using experimentally derived parameters that generates pancreatic fluid bicarbonate concentrations of >140 mM after CFTR activation. A new mathematical model was developed simulating a duct cell within a proximal pancreatic duct and included a sodium-2-bicarbonate cotransporter (NBC) and sodium-potassium pump (NaK pump) on a chloride-impermeable basolateral membrane, CFTR on the luminal membrane with 0.2 to 1 bicarbonate to chloride permeability ratio. Chloride-bicarbonate antiporters (Cl/HCO3 AP) were added or subtracted from the basolateral (APb) and luminal (APl) membranes. The model was integrated over time using XPPAUT. This model predicts robust, NaK pump-dependent bicarbonate secretion with opening of the CFTR, generates and maintains pancreatic fluid secretion with bicarbonate concentrations >140 mM, and returns to basal levels with CFTR closure. Limiting CFTR permeability to bicarbonate, as seen in some CFTR mutations, markedly inhibited pancreatic bicarbonate and fluid secretion. A simple CFTR-dependent duct cell model can explain active, high-volume, high-concentration bicarbonate secretion in pancreatic juice that reproduces the experimental findings. This model may also provide insight into why CFTR mutations that predominantly affect bicarbonate permeability predispose to pancreatic dysfunction in humans.

An Analysis of MSFC Public Affairs Television and Target Audiences with Suggestions for Future Growth and Directions

NASA Technical Reports Server (NTRS)

Smeyak, Gerald P.

1996-01-01

Because of profound changes in government and the space program, this may be an ideal time to evaluate MSFC's Public Affairs television efforts. The changes are continued downsizing of government programs; reduction in research and development; changes in the space program from periodic manned launches to a full-time presence in space with Space Station; and greater emphasis on science and communicating science information. At the same time that NASA is undergoing change, the media and society are also undergoing substantial upheaval. Twenty-five years ago, the three main over-the-air television networks (ABC, CBS and NBC) had a 93 share of the television audience. We now have four popular over-the-air networks (ABC, CBS, NBC and Fox) who maintain a 52 percent share of the television audience. Technological development, competition, and changing consumer tastes have created specialized media and audiences. This media fragmentation is part of a normal maturation cycle of use or adoption. While phases in the cycle vary in length due to many factors, the cycle has been consistent and reflects patterns of adoption. The cycle is: (1) Elite Media usage, (2) Popular or Mass Media usage, and (3) Specialized Media usage. Another factor that affects the media development and adoption cycle is the creation of new and competing mass and personal mediums. While television remains the dominant and most popular mass medium, it is declining and we see (via cable television) specialized networks catering to small audience segments. Because of changing technology and consumer behavior, we may not see a dominant mass media like television again.

Can proton pump inhibitors reduce rebleeding following Histoacryl sclerotherapy for gastric variceal hemorrhage?

PubMed

Kim, Ka Rham; Jun, Chung Hwan; Cho, Kyu Man; Wi, Jin Woo; Park, Seon Young; Cho, Sung Bum; Lee, Wan Sik; Park, Chang Hwan; Joo, Young Eun; Kim, Hyun Soo; Choi, Sung Kyu; Rew, Jong Sun

2015-09-01

To evaluate the efficacy of proton pump inhibitors (PPIs) in reducing rebleeding and bleeding-related death rates after endoscopic gastric variceal obliteration (GVO) using N-butyl-2-cyanoacrylate (NBC). This study enrolled 341 patients who were consecutively diagnosed with and treated for bleeding gastric varices. The patients were divided into PPI and non-PPI groups, and their endoscopic findings, initial hemostasis outcomes, rebleeding and bleeding-related death rates, and treatment-related complications were analyzed. The rate of initial hemostasis was 97.1%. rebleeding occurred in 2.2% of patients within 2 weeks, 3.9% of patients within 4 weeks, 18.9% of patients within 6 months, and 27.6% of patients within 12 months of the GVO procedure. A previous history of variceal bleeding (relative risk [RR], 1.955; 95% confidence interval [CI], 1.263 to 3.028; p = 0.003) and use of PPIs (RR, 0.554; 95% CI, 0.352 to 0.873; p = 0.011) were associated with rebleeding. Child-Pugh class C (RR, 10.914; 95% CI, 4.032 to 29.541; p < 0.001), failure of initial hemostasis (RR, 13.329; 95% CI, 2.795 to 63.556; p = 0.001), and the presence of red-colored concomitant esophageal varices (RR, 4.096; 95% CI, 1.320 to 12.713; p = 0.015) were associated with bleeding-related death. The prophylactic use of PPIs reduces rebleeding after GVO using NBC in patients with gastric variceal hemorrhage. However, prophylactic use of PPIs does not reduce bleeding-related death.

Effects of niobium additions on the structure, depth, and austenite grain size of the case of carburized 0.07% C steels

NASA Astrophysics Data System (ADS)

Islam, M. A.; Bepari, M. M. A.

1996-10-01

Carbon (0.07%) steel samples containing about 0.04% Nb singly and in combination with nitrogen were carburized in a natural Titas gas atmosphere at a temperature of 1223 K (950 °C) and a pressure of about 0.10 MPa for 1/2 to 4 h, followed by slow cooling in the furnace. Their microstructures were studied by optical microscopy. The austenite grain size of the case and the case depths were determined on baseline samples of low-carbon steels and also on niobium and (Nb + N) microalloyed steel samples. It was found that, when compared to the baseline steel, niobium alone or in combination with nitrogen decreased the thickness of cementite network near the surface of the carburized case of the steels. However, niobium in combination with nitrogen was more effective than niobium in reducing the thickness of cementite network. Niobium with or without nitrogen inhibited the formation of Widmanstätten cementite plates at grain boundaries and within the grains near the surface in the hypereutectoid zone of the case. It was also revealed that, when compared to the baseline steel, niobium decreased the case depth of the carburized steels, but that niobium with nitrogen is more effective than niobium alone in reducing the case depth. Niobium as niobium carbide (NbC) and niobium in the presence of nitrogen as niobium carbonitride, [Nb(C,N)] particles refined the austenite grain size of the carburized case, but Nb(C,N) was more effective than NbC in inhibiting austenite grain growth.

Nutrigenomic Analysis of Diet-Gene Interactions on Functional Supplements for Weight Management

PubMed Central

Lau, Francis C; Bagchi, Manashi; Sen, Chandan; Roy, Sashwati; Bagchi, Debasis

2008-01-01

Recent advances in molecular biology combined with the wealth of information generated by the Human Genome Project have fostered the emergence of nutrigenomics, a new discipline in the field of nutritional research. Nutrigenomics may provide the strategies for the development of safe and effective dietary interventions against the obesity epidemic. According to the World Health Organization, more than 60% of the global disease burden will be attributed to chronic disorders associated with obesity by 2020. Meanwhile in the US, the prevalence of obesity has doubled in adults and tripled in children during the past three decades. In this regard, a number of natural dietary supplements and micronutrients have been studied for their potential in weight management. Among these supplements, (–)-hydroxycitric acid (HCA), a natural extract isolated from the dried fruit rind of Garcinia cambogia, and the micronutrient niacin-bound chromium(III) (NBC) have been shown to be safe and efficacious for weight loss. Utilizing cDNA microarrays, we demonstrated for the first time that HCA-supplementation altered the expression of genes involved in lipolytic and adipogenic pathways in adipocytes from obese women and up-regulated the expression of serotonin receptor gene in the abdominal fat of rats. Similarly, we showed that NBC-supplementation up-regulated the expression of myogenic genes while suppressed the expression of genes that are highly expressed in brown adipose tissue in diabetic obese mice. The potential biological mechanisms underlying the observed beneficial effects of these supplements as elucidated by the state-of-the-art nutrigenomic technologies will be systematically discussed in this review. PMID:19452041

Effect of alloy composition on high-temperature bending fatigue strength of ferritic stainless steels

NASA Astrophysics Data System (ADS)

Ahn, Yong-Sik; Song, Jeon-Young

2011-12-01

Exhaust manifolds are subjected to an environment in which heating and cooling cycles occur due to the running pattern of automotive engines. This temperature profile results in the repeated bending stress of exhaust pipes. Therefore, among high-temperature characteristics, the bending fatigue strength is an important factor that affects the lifespan of exhaust manifolds. Here, we report on the effect of the alloy composition, namely the weight fraction of the elements Cr, Mo, Nb, and Ti, on the high-temperature bending fatigue strength of the ferritic stainless steel used in exhaust manifolds. Little difference in the tensile strength and bending fatigue strength of the different composition steels was observed below 600 °C, with the exception of the low-Cr steel. However, steels with high Cr, Mo, or Nb fractions showed considerably larger bending fatigue strength at temperatures of 800 °C. After heating, the precipitates from the specimens were extracted electrolytically and analyzed using scanning electron microscopy energy dispersive spectrometry and transmission electron microscopy. Alloying with Cr and Mo was found to increase the bending fatigue strength due to the substitutional solid solution effect, while alloying with Nb enhanced the strength by forming fine intermetallic compounds, including NbC and Fe2Nb.

Hydrogen Cracking in Gas Tungsten Arc Welding of an AISI Type 321 Stainless Steel

NASA Astrophysics Data System (ADS)

Rozenak, P.; Unigovski, Ya.; Shneck, R.

The effects of in situ cathodic charging on the tensile properties and susceptibility to cracking of an AISI type 321 stainless steel, welded by the gas tungsten arc welding (GTAW) process, was studied by various treatments. Appearance of delta-ferrite phase in the as-welded steels in our tested conditions was observed with discontinuous grain boundaries (M23C6) and a dense distribution of metal carbides MC ((Ti, Nb)C), which precipitated in the matrix. Shielding gas rates changes the mechanical properties of the welds. Ultimate tensile strength and ductility are increases with the resistance to the environments related the increase of the supplied shielding inert gas rates. Charged specimens, caused mainly in decreases in the ductility of welded specimens. However, more severe decrease in ductility was obtained after post weld heat treatment (PWHT). The fracture of sensitized specimens was predominantly intergranular, whereas the as-welded specimens exhibited massive transgranular regions. Both types of specimen demonstrated narrow brittle zones at the sides of the fracture surface and ductile micro-void coalescences in the middle. Ferrite δ was form after welding with high density of dislocation structures and stacking faults formation and the thin stacking fault plates with e-martensite phase were typically found in the austenitic matrix after the cathodical charging process.

Exploring the meaning of practicing classroom inquiry from the perspectives of National Board Certified Science Teachers

NASA Astrophysics Data System (ADS)

Karaman, Ayhan

Inquiry has been one of the most prominent terms of the contemporary science education reform movement (Buck, Latta, & Leslie-Pelecky, 2007; Colburn, 2006; Settlage, 2007). Practicing classroom inquiry has maintained its central position in science education for several decades because science education reform documents promote classroom inquiry as the potential savior of science education from its current problems. Likewise, having the capabilities of teaching science through inquiry has been considered by National Board for Professional Teaching Standards [NBPTS] as one of the essential elements of being an accomplished science teacher. Successful completion of National Board Certification [NBC] assessment process involves presenting a clear evidence of enacting inquiry with students. Despite the high-profile of the word inquiry in the reform documents, the same is not true in schools (Crawford, 2007). Most of the science teachers do not embrace this type of approach in their everyday teaching practices of science (Johnson, 2006; Luera, Moyer, & Everett, 2005; Smolleck, Zembal-Saul, & Yoder, 2006; Trumbull, Scarano, & Bonney, 2006). And the specific meanings attributed to inquiry by science teachers do not necessarily match with the original intentions of science education reform documents (Matson & Parsons, 2006; Wheeler, 2000; Windschitl, 2003). Unveiling the various meanings held by science teachers is important in developing better strategies for the future success of science education reform efforts (Jones & Eick, 2007; Keys & Bryan, 2001). Due to the potential influences of National Board Certified Science Teachers [NBCSTs] on inexperienced science teachers as their mentors, examining inquiry conceptions of NBCSTs is called for. How do these accomplished practitioners understand and enact inquiry? The purpose of this dissertation research study was twofold. First, it investigated the role of NBC performance assessment process on the professional development of science teachers. Second, it examined the meaning of practicing classroom inquiry for National Board Certified Science Teachers [NBCSTs]. Based on the specific cases of four NBCSTs, this naturalistic inquiry study was conducted to answer to those questions with the involvement of the following qualitative data sources: classroom observations, in-depth teacher interviews, and document analyses of teacher portfolios. The specific cases in this study indicated that undergoing the performance assessment process of NBC played an affirmational role for National Board Certified Science Teachers [NBCSTs] in their professional development. Their successful completion of the portfolio assessment process created a sharpened confidence into their existing notions and ways of teaching science. In the study, not all teachers were equally open to science education reform ideas. This meant that NBC experience strengthened the conventional notions of teaching science held by some teachers rather than generating a higher affiliation with the reform ideas. The teacher cases presented in this study denoted that teachers' conceptions of classroom inquiry were driven both by scientific and constructivist rationales. However, NBCSTs failed to create broader operational definitions of classroom inquiry. They tended to reduce the meaning of classroom inquiry into empirical investigations of students. The conventional representation of the scientific method as a stepwise linear process influenced teachers' understandings and practices of classroom inquiry. NBCSTs used inquiry in their classrooms to introduce their students to the cognitive processes and the actions of practicing scientists but not necessarily to teach scientific principles. Their reluctance to teach scientific principles through inquiry developed in parallel to their tendency of associating classroom inquiry with the highest levels of student autonomy. Participant teachers' particular understandings of scientific literacy produced a tension between embracing inquiry more in their teaching practices of science and educating scientifically literate students. The teachers in the study attributed the hurdles that kept them from using more inquiry with their students to external factors. In the final chapter of the dissertation study, these findings were discussed in connection with the education literature.

Life-Cycle Cost Analysis for Small Unmanned Aircraft Systems Deployed Aboard Coast Guard Cutters

DTIC Science & Technology

2013-12-09

safest way to survey the NBC disaster site. “Swarms could scan high-risk buildings and sites (think Fukushima ^Åèìáëáíáçå=oÉëÉ~êÅÜ=mêçÖê~ã= dê~Çì~íÉ...in 1997 with a degree in mechanical engineering. After graduation, he served onboard USCGC Thetis (WMEC-910) as the student engineer and damage...the surrounding area with his family. After graduation in December 2013, he will report to the In-Service Vessel Sustainment Project as assistant

Programmable Nano-Bio-Chip Sensors: Analytical Meets Clinical

PubMed Central

Jokerst, Jesse V.; Floriano, Pierre N.; Christodoulides, Nicolaos; McDevitt, John T.; Jacobson, James W.; Bhagwandin, Bryon D.

2010-01-01

synopsis There have been many recent advances in the nano-bio-chip (NBC) analysis methodology with implications for a number of high-morbidity diseases including HIV, cancer, and heart disease. In their Feature article, Jesse V. Jokerst of The University of Texas at Austin; Pierre N. Floriano, Nicolaos Christodoulides, and John T. McDevitt of Rice University; and James W. Jacobson and Bryon D. Bhagwandin of LabNow, Inc. discuss the construction, capabilities, and advantages of NBCs. The cover shows arrays of NBCs. Images courtesy of Glennon Simmons/McDevitt Lab and Marcha Miller of The University of Texas at Austin. PMID:20128622

Composition and Temperature Dependence of Shear Viscosity of Hydrocarbon Mixtures

DTIC Science & Technology

1980-07-01

HNN- XTHDCPD Binary System IX. VTF Eq. Parameters for Shear Viscosities Using Constant B Parameter X. Results of Fits to Master Viscosity Eqs. (43...T(K) for 5 C10 Hydrocarbons I Fig. 2a. log n versus 103/T(K) for HNNi I Fig. 2b. log n versus 103/T(K) for XTHDCPD Fig. 3. Isothem of log n versus X...CD for CO-MO Binary System Fig. 4. Isotherm of log n versus XNBC for NBC-DMO Binary System ( ~Fig. 5. Isotherm of log n versus XfINN for HNN- XTHDCPD

The 1986 ARI (Army Research Institute) Survey of U.S. Army Recruits: Media Habits

DTIC Science & Technology

1988-04-01

EDGAR M. JOHNSONCOI Technical Director Cmadn Technical review by Accesion For Curtis L. Gilroy NTAS CRA&:AI Laurel N. Oliver DI A UnC ABm~jc NOTICES...NBC SOURCE T681 X240 SOLID GOLD X241 SOUL TRAIN X242 AMERICAN BANDSTAND X243 DANCE FEVER U" X244 MOVIES ON NETWORK TV X755 MUSIC VIDEOS (NOT...BLACKE’S MAGIC Y080 MOONLIGHTING Y081 MACGIVER Y082 STINGRAY Y083 AIRWOLF Y084 THE A-TEAM Y085 HUNTER Y086 MIAMI VICE Y087 HARDCASTLE AND MCCORMICK Y088

User’s Manual for the AFSATCOM Terminal Upgrades Life Cycle Cost Model. Volume I.

DTIC Science & Technology

1981-10-01

EFAIL (I,NS)*TNB(NS) NS *I[LRU(I) + RTS(NHI(I))]*NRTS(I)*DRCT(LO(NS)) + NRTS(NHI(I))*(l - COND(I))*DAD) where TNB(NS) = total number of bases within the...required anywhere in the ATU logistics system, i.e., if it ever fails, and equals 0 otherwise. Computed by: IUT(I) = U( EFAIL (I,NS)) NS IMC = initial depot...I)*XFPR*BRCT + CIMF(NS)* EFAIL (I,B)*NBC(B)LRU(I)*FINC*FPR(I)*XFPR*CRCT B NHB(B)=NS The terms in the equation for TDFPR(I) above account for increases

THE NEWEST CHAPTER IN COUNTERINSURGENCY OPERATIONS: DEFEATING THE ISLAMIC STATE OF IRAQ AND THE LEVANT EXPLORING HOW TO SUCCEED IN LIGHT OF RECENT COUNTERINSURGENCY OPERATIONS THAT YIELDED LIMITED OR NO SUCCESS

DTIC Science & Technology

2015-10-01

concerns. Third, insurgent support bases and activities in Pakistan needed be eliminated. In every Afghanistan insurgency since 1979 , insurgents have...Vinograd, “ISIS Attacks Soared in Past 3 Months: HIS Jane’s Database”, web 136. Vinograd, “Are the Airstrike Against ISIS Working?”, web...Attacks Soared in Past 3 Months: IHS Jane’s Database.” NBC News, 21 Oct 2015. Web. 24 Oct 2015. Welna, David. “After A Year of Bombing ISIS

Chronicler's Induction Ceremony

NASA Image and Video Library

2017-05-05

A poster in the NASA News Center at Kennedy Space Center in Florida bears the names and photos of the six new honorees added to the facility's "Chroniclers" roll of honor. The Chroniclers program recognizes retirees of the news and communications business who helped spread news of American space exploration from Kennedy Space Center for ten years or more. From top left to bottom right are Phillip Sandlin, Associated Press photographer; Bill Johnson, NASA Public Affairs; Bruce Hall, CBS News and NBC News; Scott Harris, WESH, WKMG and Central Florida News 13; Warren Leary, The New York Times; and Bob Murray, WDBO-TV, RCA and United Space Alliance.

America’s Air Force, The Future Calls: An Evidentiary and Theoretical Analysis Of The Roles And Missions Of A USAF Astronaut Corps

DTIC Science & Technology

2016-06-01

wT0S8qQLCOqh. ; Keith Wagstaff, “ Elon Musk Says SpaceX Will Send People to Mars By 2025,” NBC News, 29 January 2016, Accessed 22 February 2016...http://www.nbcnews.com/tech/tech-news/ elon - musk -says-spacex-will-send-people- mars-2025-n506891. 76. “About Mars One,” Mars-One.com, 2016, Accessed 22...January 2014. Accessed 22 February 2016. https://www.stratcom.mil/factsheets/11/Space_Control_and_Space_Surveillan ce/. Wagstaff, Keith. “ Elon Musk Says

KSC-20170505-PH_CSH01_0003

NASA Image and Video Library

2017-05-05

Brass strips bear the names and photos of the six new honorees added to the "Chroniclers" roll of honor in the NASA News Center at Kennedy Space Center in Florida. The Chroniclers program recognizes retirees of the news and communications business who helped spread news of American space exploration from Kennedy Space Center for ten years or more. The 2017 Chroniclers are Bruce Hall, CBS News and NBC News; Scott Harris, WESH, WKMG and Central Florida News 13; Bill Johnson, NASA Public Affairs; Warren Leary, The New York Times; Bob Murray, WDBO-TV, RCA and United Space Alliance; and Phillip Sandlin, Associated Press photographer.

Sally Ride Women in Science Panel

NASA Image and Video Library

2013-05-17

Panel discussion participants, from left, Linda Billings, research professor, Media and Public Affairs, The George Washington University, Ellen Ochoa, director, NASA Johnson Space Center, Tom Costello, NBC News and moderator for the event, Margaret Weitekamp, space history curator, National Air and Space Museum, Dan Vergano, science writer for USA Today, and Rene McCormick, director of standards and quality, National Math and Science Initiative, are seen during a program titled "Sally Ride: How Her Historic Space Mission Opened Doors for Women in Science" held on Friday, May 17, 2013 at the National Air and Space Museum in Washington. Photo Credit: (NASA/Bill Ingalls)

Wrought stainless steel compositions having engineered microstructures for improved heat resistance

DOEpatents

Maziasz, Philip J [Oak Ridge, TN; Swindeman, Robert W [Oak Ridge, TN; Pint, Bruce A [Knoxville, TN; Santella, Michael L [Knoxville, TN; More, Karren L [Knoxville, TN

2007-08-21

A wrought stainless steel alloy composition includes 12% to 25% Cr, 8% to 25% Ni, 0.05% to 1% Nb, 0.05% to 10% Mn, 0.02% to 0.15% C, 0.02% to 0.5% N, with the balance iron, the composition having the capability of developing an engineered microstructure at a temperature above 550.degree. C. The engineered microstructure includes an austenite matrix having therein a dispersion of intragranular NbC precipitates in a concentration in the range of 10.sup.10 to 10.sup.17 precipitates per cm.sup.3.

Bayesian integration of sensor information and a multivariate dynamic linear model for prediction of dairy cow mastitis.

PubMed

Jensen, Dan B; Hogeveen, Henk; De Vries, Albert

2016-09-01

Rapid detection of dairy cow mastitis is important so corrective action can be taken as soon as possible. Automatically collected sensor data used to monitor the performance and the health state of the cow could be useful for rapid detection of mastitis while reducing the labor needs for monitoring. The state of the art in combining sensor data to predict clinical mastitis still does not perform well enough to be applied in practice. Our objective was to combine a multivariate dynamic linear model (DLM) with a naïve Bayesian classifier (NBC) in a novel method using sensor and nonsensor data to detect clinical cases of mastitis. We also evaluated reductions in the number of sensors for detecting mastitis. With the DLM, we co-modeled 7 sources of sensor data (milk yield, fat, protein, lactose, conductivity, blood, body weight) collected at each milking for individual cows to produce one-step-ahead forecasts for each sensor. The observations were subsequently categorized according to the errors of the forecasted values and the estimated forecast variance. The categorized sensor data were combined with other data pertaining to the cow (week in milk, parity, mastitis history, somatic cell count category, and season) using Bayes' theorem, which produced a combined probability of the cow having clinical mastitis. If this probability was above a set threshold, the cow was classified as mastitis positive. To illustrate the performance of our method, we used sensor data from 1,003,207 milkings from the University of Florida Dairy Unit collected from 2008 to 2014. Of these, 2,907 milkings were associated with recorded cases of clinical mastitis. Using the DLM/NBC method, we reached an area under the receiver operating characteristic curve of 0.89, with a specificity of 0.81 when the sensitivity was set at 0.80. Specificities with omissions of sensor data ranged from 0.58 to 0.81. These results are comparable to other studies, but differences in data quality, definitions of clinical mastitis, and time windows make comparisons across studies difficult. We found the DLM/NBC method to be a flexible method for combining multiple sensor and nonsensor data sources to predict clinical mastitis and accommodate missing observations. Further research is needed before practical implementation is possible. In particular, the performance of our method needs to be improved in the first 2 wk of lactation. The DLM method produces forecasts that are based on continuously estimated multivariate normal distributions, which makes forecasts and forecast errors easy to interpret, and new sensors can easily be added. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Vapour breakthrough behaviour of carbon tetrachloride - A simulant for chemical warfare agent on ASZMT carbon: A comparative study with whetlerite carbon

NASA Astrophysics Data System (ADS)

Srivastava, Avanish Kumar; Shah, Dilip K.; Mahato, T. H.; Roy, A.; Yadav, S. S.; Srivas, S. K.; Singh, Beer

2013-06-01

ASZMT and whetlerite carbon was prepared by impregnation of active carbon with ammonical salts of Cu (II), Ag (I), Zn (II), Mo (VI), TEDA and Cu (II), Ag (I), Cr (VI), NaOH, C5H5N respectively using incipient wetness technique. Thereafter, impregnated carbon systems were characterized using scanning electron microscopy, energy dispersive X-ray, atomic absorption spectroscopy, thermogravimetry and surface characterization techniques. Impregnated carbon systems were evaluated under dynamic conditions against carbon tetrachloride (CCl4) vapour that was used as a simulant for the persistent chemical warfare agents for testing breakthrough times of filter cartridges and canisters of gas masks in the national approval test of respirators. The protective potential of ASZMT carbon was compared with the whetlerite carbon which is presently used in NBC filtration system. The effect of CCl4 concentration, test flow rate, temperature and relative humidity on the breakthrough behaviour of the impregnated carbon systems has also been studied. The study clearly indicated that the whetlerite carbon possessed breakthrough time greater than ASZMT carbon. However, ASZMT carbon provided adequate protection against CCl4 vapours and can be used as an alternative to whetlerite carbon that contain Cr(VI), which is reported to be carcinogenic and having lesser shelf life. The study indicated the breakthrough time of impregnated carbon systems were found to decrease with the increase of the CCl4 concentration and flow rate. The variation in temperature and relative humidity did not significantly affect the breakthrough behaviour of impregnated carbon systems at high vapour concentration of CCl4 whereasbreak through time of impregnated carbon systems reduced by an increase of relative humidity at low CCl4 vapour concentration.

Seasonal Progression of the Deposition of Black Carbon by Snowfall at Ny-Ålesund, Spitsbergen

NASA Astrophysics Data System (ADS)

Sinha, P. R.; Kondo, Y.; Goto-Azuma, K.; Tsukagawa, Y.; Fukuda, K.; Koike, M.; Ohata, S.; Moteki, N.; Mori, T.; Oshima, N.; Førland, E. J.; Irwin, M.; Gallet, J.-C.; Pedersen, C. A.

2018-01-01

Deposition of black carbon (BC) aerosol in the Arctic lowers snow albedo, thus contributing to warming in the region. However, the processes and impacts associated with BC deposition are poorly understood because of the scarcity and uncertainties of measurements of BC in snow with adequate spatiotemporal resolution. We sampled snowpack at two sites (11 m and 300 m above sea level) at Ny-Ålesund, Spitsbergen, in April 2013. We also collected falling snow near the surface with a windsock from September 2012 to April 2013. The size distribution of BC in snowpack and falling snow was measured using a single-particle soot photometer combined with a characterized nebulizer. The BC size distributions did not show significant variations with depth in the snowpack, suggesting stable size distributions in falling snow. The BC number and mass concentrations (CNBC and CMBC) at the two sites agreed to within 19% and 10%, respectively, despite the sites' different snow water equivalent (SWE) loadings. This indicates the small influence of the amount of SWE (or precipitation) on these quantities. Average CNBC and CMBC in snowpack and falling snow at nearly the same locations agreed to within 5% and 16%, after small corrections for artifacts associated with the sampling of the falling snow. This comparison shows that the dry deposition was a small contributor to the total BC deposition. CMBC were highest (2.4 ± 3.0 μg L-1) in December-February and lowest (1.2 ± 1.2 μg L-1) in September-November.

Thermal evolution of the western South Atlantic and the adjacent continent during Termination 1

NASA Astrophysics Data System (ADS)

Chiessi, C. M.; Mulitza, S.; Mollenhauer, G.; Silva, J. B.; Groeneveld, J.; Prange, M.

2015-06-01

During Termination 1, millennial-scale weakening events of the Atlantic meridional overturning circulation (AMOC) supposedly produced major changes in sea surface temperatures (SSTs) of the western South Atlantic, and in mean air temperatures (MATs) over southeastern South America. It has been suggested, for instance, that the Brazil Current (BC) would strengthen (weaken) and the North Brazil Current (NBC) would weaken (strengthen) during slowdown (speed-up) events of the AMOC. This anti-phase pattern was claimed to be a necessary response to the decreased North Atlantic heat piracy during periods of weak AMOC. However, the thermal evolution of the western South Atlantic and the adjacent continent is so far largely unknown. Here we address this issue, presenting high-temporal-resolution SST and MAT records from the BC and southeastern South America, respectively. We identify a warming in the western South Atlantic during Heinrich Stadial 1 (HS1), which is followed first by a drop and then by increasing temperatures during the Bølling-Allerød, in phase with an existing SST record from the NBC. Additionally, a similar SST evolution is shown by a southernmost eastern South Atlantic record, suggesting a South Atlantic-wide pattern in SST evolution during most of Termination 1. Over southeastern South America, our MAT record shows a two-step increase during Termination 1, synchronous with atmospheric CO2 rise (i.e., during the second half of HS1 and during the Younger Dryas), and lagging abrupt SST changes by several thousand years. This delay corroborates the notion that the long duration of HS1 was fundamental in driving the Earth out of the last glacial.

Adsorption and diffusion of Au atoms on the (001) surface of Ti, Zr, Hf, V, Nb, Ta, and Mo carbides.

PubMed

Florez, Elizabeth; Viñes, Francesc; Rodriguez, Jose A; Illas, Francesc

2009-06-28

The adsorption of atomic Au on the (001) surface of TiC, ZrC, HfC, VC, NbC, TaC, and delta-MoC and the mechanism of diffusion of this adatom through the surface have been studied in terms of a periodic density functional theory based approach. In all the cases, the Au adsorption energies are in the range of 1.90-2.35 eV. The moderately large adsorption energies allow the Au diffusion before desorption could take place. For TiC(001), ZrC(001), and HfC(001), atomic Au is adsorbed directly on top of C atoms and diffusion takes place along the diagonal of the squares formed by M-C-M-C atoms with the transition state located above the hollow sites. For the rest of transition metal carbides the situation is less simple with the appearance of more than one stable adsorption site, as for NbC and TaC, of a small energy barrier for diffusion around the most stable adsorption site and of a more complex diffusion pathway. The small energy barrier for diffusion around the most stable site will result in a highly mobile Au species which could be observed in scanning tunnel microscope experiments. After depositing Au on metal-carbide surfaces, there is a noticeable charge transfer from the substrate to the adsorbed Au atom. The electronic perturbations on Au increase when going from TiC to ZrC or TaC. Our results indicate that metal carbides should be better supports for the chemical activation of Au than metal oxides.

Indoor Air Nuclear, Biological, and Chemical Health Modeling and Assessment System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stenner, Robert D.; Hadley, Donald L.; Armstrong, Peter R.

2001-03-01

Indoor air quality effects on human health are of increasing concern to public health agencies and building owners. The prevention and treatment of 'sick building' syndrome and the spread of air-borne diseases in hospitals, for example, are well known priorities. However, increasing attention is being directed to the vulnerability of our public buildings/places, public security and national defense facilities to terrorist attack or the accidental release of air-borne biological pathogens, harmful chemicals, or radioactive contaminants. The Indoor Air Nuclear, Biological, and Chemical Health Modeling and Assessment System (IA-NBC-HMAS) was developed to serve as a health impact analysis tool for usemore » in addressing these concerns. The overall goal was to develop a user-friendly fully functional prototype Health Modeling and Assessment system, which will operate under the PNNL FRAMES system for ease of use and to maximize its integration with other modeling and assessment capabilities accessible within the FRAMES system (e.g., ambient air fate and transport models, water borne fate and transport models, Physiologically Based Pharmacokinetic models, etc.). The prototype IA-NBC-HMAS is designed to serve as a functional Health Modeling and Assessment system that can be easily tailored to meet specific building analysis needs of a customer. The prototype system was developed and tested using an actual building (i.e., the Churchville Building located at the Aberdeen Proving Ground) and release scenario (i.e., the release and measurement of tracer materials within the building) to ensure realism and practicality in the design and development of the prototype system. A user-friendly "demo" accompanies this report to allow the reader the opportunity for a "hands on" review of the prototype system's capability.« less

Role of an extracellular loop in determining the stoichiometry of Na+–HCO3− cotransporters

PubMed Central

Chen, Li-Ming; Liu, Ying; Boron, Walter F

2011-01-01

The Na+–HCO3− cotransporters (NBCs) of the solute carrier 4 family (SLC4) are critical for regulating pH in cells as well as in fluids such as blood and cerebrospinal fluid. Moreover, mutations and gene disruptions in NBC are linked to a wide range of pathologies. NBCe1 (SLC4A4) is electrogenic because it has an apparent Na+:HCO3− stoichiometry of 1:2 or 1:3, whereas NBCn1 (SLC4A7) is electroneutral because it has an apparent stoichiometry of 1:1. Because stoichiometry influences the effect of transport on membrane potential and vice versa, a central question is what structural features underlie electrogenicity versus electroneutrality. A previous study on rat NBCe1/n1 chimeras demonstrated that the structural elements determining the electrogenicity of NBCe1-A are located within the transmembrane domain, excluding the large third extracellular loop. In the present study we generated a series of chimeras of human NBCe1-A and human NBCn1-A. We found that replacing merely the predicted fourth extracellular loop (EL4) – containing 32 amino acid residues that include 7 prolines – of human NBCe1-A with EL4 of NBCn1-A creates an electroneutral NBC. The opposite switch converts an electroneutral construct to one with electrogenic properties. The introduction of an N-glycosylation site into EL4 confirms that at least a part of it is exposed to the extracellular fluid. We hypothesize that putative EL4 either contributes to the substrate-binding vestibule or indirectly influences substrate binding by interacting with one or more transmembrane segments, thereby controlling the nature of transport. PMID:21224233

Alumina-Forming Austenitic Stainless Steels Strengthened by Laves Phase and MC Carbide Precipitates

NASA Astrophysics Data System (ADS)

Yamamoto, Y.; Brady, M. P.; Lu, Z. P.; Liu, C. T.; Takeyama, M.; Maziasz, P. J.; Pint, B. A.

2007-11-01

Creep strengthening of Al-modified austenitic stainless steels by MC carbides or Fe2Nb Laves phase was explored. Fe-20Cr-15Ni-(0-8)Al and Fe-15Cr-20Ni-5Al base alloys (at. pct) with small additions of Nb, Mo, W, Ti, V, C, and B were cast, thermally-processed, and aged. On exposure from 650 °C to 800 °C in air and in air with 10 pct water vapor, the alloys exhibited continuous protective Al2O3 scale formation at an Al level of only 5 at. pct (2.4 wt pct). Matrices of the Fe-20Cr-15Ni-5Al base alloys consisted of γ (fcc) + α (bcc) dual phase due to the strong α-Fe stabilizing effect of the Al addition and exhibited poor creep resistance. However, adjustment of composition to the Fe-15Cr-20Ni-5Al base resulted in alloys that were single-phase γ-Fe and still capable of alumina scale formation. Alloys that relied solely on Fe2Nb Laves phase precipitates for strengthening exhibited relatively low creep resistance, while alloys that also contained MC carbide precipitates exhibited creep resistance comparable to that of commercially available heat-resistant austenitic stainless steels. Phase equilibria studies indicated that NbC precipitates in combination with Fe2Nb were of limited benefit to creep resistance due to the solution limit of NbC within the γ-Fe matrix of the alloys studied. However, when combined with other MC-type strengtheners, such as V4C3 or TiC, higher levels of creep resistance were obtained.

Taxonomic and thematic organisation of proper name conceptual knowledge.

PubMed

Crutch, Sebastian J; Warrington, Elizabeth K

2011-01-01

We report the investigation of the organisation of proper names in two aphasic patients (NBC and FBI). The performance of both patients on spoken word to written word matching tasks was inconsistent, affected by presentation rate and semantic relatedness of the competing responses, all hallmarks of a refractory semantic access dysphasia. In a series of experiments we explored the semantic relatedness effects within their proper name vocabulary, including brand names and person names. First we demonstrated the interaction between very fine grain organisation and personal experience, with one patient with a special interest in the cinema demonstrating higher error rates when identifying the names of actors working in a similar film genre (e.g., action movies: Arnold Schwarzenegger, Bruce Willis, Sylvester Stallone, Mel Gibson) than those working in different genres (e.g., Arnold Schwarzenegger, Gregory Peck, Robin Williams, Gene Kelly). Second we compared directly two potential principles of semantic organisation - taxonomic and thematic. Furthermore we considered these principles of organisation in the context of the individuals' personal knowledge base. We selected topics matching the interests and experience of each patient, namely cinema and literature (NBC) and naval history (FBI). The stimulus items were arranged in taxonomic arrays (e.g., Jane Austen, Emily Bronte, Agatha Christie), thematic arrays (e.g., Jane Austen, Pride and Prejudice, Mr Darcy), and unrelated arrays (e.g., Jane Austen, Wuthering Heights, Hercule Poirot). We documented that different patterns of taxonomic and thematic organisation were constrained by whether the individual has limited knowledge, moderate knowledge or detailed knowledge of a particular vocabulary. It is suggested that moderate proper name knowledge is primarily organised by taxonomy whereas extensive experience results in a more detailed knowledge base in which theme is a powerful organising principle.

Taxonomic and Thematic Organisation of Proper Name Conceptual Knowledge

PubMed Central

Crutch, Sebastian J.; Warrington, Elizabeth K.

2011-01-01

We report the investigation of the organisation of proper names in two aphasic patients (NBC and FBI). The performance of both patients on spoken word to written word matching tasks was inconsistent, affected by presentation rate and semantic relatedness of the competing responses, all hallmarks of a refractory semantic access dysphasia. In a series of experiments we explored the semantic relatedness effects within their proper name vocabulary, including brand names and person names. First we demonstrated the interaction between very fine grain organisation and personal experience, with one patient with a special interest in the cinema demonstrating higher error rates when identifying the names of actors working in a similar film genre (e.g. action movies: Arnold Schwarzenegger, Bruce Willis, Sylvester Stallone, Mel Gibson) than those working in different genres (e.g. Arnold Schwarzenegger, Gregory Peck, Robin Williams, Gene Kelly). Second we compared directly two potential principles of semantic organisation – taxonomic and thematic. Furthermore we considered these principles of organisation in the context of the individuals' personal knowledge base. We selected topics matching the interests and experience of each patient, namely cinema and literature (NBC) and naval history (FBI). The stimulus items were arranged in taxonomic arrays (e.g. Jane Austen, Emily Bronte, Agatha Christie), thematic arrays (e.g. Jane Austen, Pride and Prejudice, Mr Darcy), and unrelated arrays (e.g. Jane Austen, Wuthering Heights, Hercule Poirot). We documented that different patterns of taxonomic and thematic organisation were constrained by whether the individual has limited knowledge, moderate knowledge or detailed knowledge of a particular vocabulary. It is suggested that moderate proper name knowledge is primarily organised by taxonomy whereas extensive experience results in a more detailed knowledge base in which theme is a powerful organising principle. PMID:22063815

Effect of Nb Addition to Ti-Bearing Super Martensitic Stainless Steel on Control of Austenite Grain Size and Strengthening

NASA Astrophysics Data System (ADS)

Ma, Xiaoping; Langelier, Brian; Gault, Baptiste; Subramanian, Sundaresa

2017-05-01

The role of Nb in normalized and tempered Ti-bearing 13Cr5Ni2Mo super martensitic stainless steel is investigated through in-depth characterization of the bimodal chemistry and size of Nb-rich precipitates/atomic clusters and Nb in solid solution. Transmission electron microscopy and atom probe tomography are used to analyze the samples and clarify precipitates/atom cluster interactions with dislocations and austenite grain boundaries. The effect of 0.1 wt pct Nb addition on the promotion of (Ti, Nb)N-Nb(C,N) composite precipitates, as well as the retention of Nb in solution after cooling to room temperature, are analyzed quantitatively. (Ti, Nb)N-Nb(C,N) composite precipitates with average diameters of approximately 24 ± 8 nm resulting from epitaxial growth of Nb(C,N) on pre-existing (Ti,Nb)N particles, with inter-particle spacing on the order of 205 ± 68 nm, are found to be associated with mean austenite grain size of 28 ± 10 µm in the sample normalized at 1323 K (1050 °C). The calculated Zener limiting austenite grain size of 38 ± 13 µm is in agreement with the experimentally observed austenite grain size distribution. 0.08 wt pct Nb is retained in the as-normalized condition, which is able to promote Nb(C, N) atomic clusters at dislocations during tempering at 873 K (600 °C) for 2 hours, and increases the yield strength by 160 MPa, which is predicted to be close to maximum increase in strengthening effect. Retention of solute Nb before tempering also leads to it preferentially combing with C and N to form Nb(C, N) atom clusters, which suppresses the occurrence of Cr- and Mo-rich carbides during tempering.

Modeling the Blast Load Simulator Airblast Environment using First Principles Codes. Report 1, Blast Load Simulator Environment

DTIC Science & Technology

2016-11-01

ER D C/ G SL T R- 16 -3 1 Modeling the Blast Load Simulator Airblast Environment Using First Principles Codes Report 1, Blast Load...Simulator Airblast Environment using First Principles Codes Report 1, Blast Load Simulator Environment Gregory C. Bessette, James L. O’Daniel...evaluate several first principles codes (FPCs) for modeling airblast environments typical of those encountered in the BLS. The FPCs considered were

Presence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in waste waters, Kinshasa, the Democratic Republic of the Congo.

PubMed

De Boeck, H; Lunguya, O; Muyembe, J-J; Glupczynski, Y; Jacobs, J

2012-11-01

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are a major public health concern. We previously demonstrated the presence of ESBL-producing Enterobacteriaceae in sachet-packaged water bags sold in Kinshasa, the Democratic Republic of the Congo. In complement to the previous study, we aimed to assess the presence of ESBL-producing Enterobacteriaceae in waste waters in Kinshasa.Enterobacteriaceae isolates recovered from environmental water samples were screened and phenotypically confirmed as ESBL-producers by disk diffusion according to Clinical and Laboratory Standards Institute (CLSI) guidelines (CLSI M100-S21). Final identification to the species level and further antimicrobial susceptibility testing were carried out with MicroScan® NBC42 panels and the identification of bla (ESBL) coding genes was performed by a commercial multiplex ligation polymerase chain reaction (PCR) microarray (Check-Points CT 101, Wageningen, the Netherlands). Overall, 194 non-duplicate Enterobacteriaceae were recovered from several sewer and river sites in nine out of 24 municipalities of Kinshasa. Fourteen isolates (7.4 %) were confirmed as ESBL-producers, the main species being Enterobacter cloacae (46.6 %) and Klebsiella pneumoniae (40.0 %). Associated resistance to both aminoglycoside and fluoroquinolone antibiotics was observed in ten isolates; the remaining isolates showed co-resistance to either fluoroquinolone (n = 3) or to aminoglycoside (n = 1) alone. All but one isolate carried bla (CTX-M) genes belonging to the CTX-M-1 group. ESBL-producing Enterobacteriaceae are increasingly being reported from various sources in the community. The present results suggest that ESBL-producing Enterobacteriaceae are widespread in the environment in the community of Kinshasa. Cities in Central Africa should be added to the map of potentially ESBL-contaminated environments and highlight the need to reinforce safe water supply and public sanitation.

Multigeneration Cross Contamination of Mail with Bacillus Species Spores by Tumbling ▿

PubMed Central

Edmonds, Jason; Clark, Paul; Williams, Leslie; Lindquist, H. D. Alan; Martinez, Kenneth; Gardner, Warren; Shadomy, Sean; Hornsby-Myers, Jennifer

2010-01-01

In 2001, envelopes loaded with Bacillus anthracis spores were mailed to Senators Daschle and Leahy as well as to the New York Post and NBC News buildings. Additional letters may have been mailed to other news agencies because there was confirmed anthrax infection of employees at these locations. These events heightened the awareness of the lack of understanding of the mechanism(s) by which objects contaminated with a biological agent might spread disease. This understanding is crucial for the estimation of the potential for exposure to ensure the appropriate response in the event of future attacks. In this study, equipment to simulate interactions between envelopes and procedures to analyze the spread of spores from a “payload” envelope (i.e., loaded internally with a powdered spore preparation) onto neighboring envelopes were developed. Another process to determine whether an aerosol could be generated by opening contaminated envelopes was developed. Subsequent generations of contaminated envelopes originating from a single payload envelope showed a consistent two-log decrease in the number of spores transferred from one generation to the next. Opening a tertiary contaminated envelope resulted in an aerosol containing 103 B. anthracis spores. We developed a procedure for sampling contaminated letters by a nondestructive method aimed at providing information useful for consequence management while preserving the integrity of objects contaminated during the incident and preserving evidence for law enforcement agencies. PMID:20511424

Oxidation resistant high creep strength austenitic stainless steel

DOEpatents

Brady, Michael P.; Pint, Bruce A.; Liu, Chain-Tsuan; Maziasz, Philip J.; Yamamoto, Yukinori; Lu, Zhao P.

2010-06-29

An austenitic stainless steel displaying high temperature oxidation and creep resistance has a composition that includes in weight percent 15 to 21 Ni, 10 to 15 Cr, 2 to 3.5 Al, 0.1 to 1 Nb, and 0.05 to 0.15 C, and that is free of or has very low levels of N, Ti and V. The alloy forms an external continuous alumina protective scale to provide a high oxidation resistance at temperatures of 700 to 800.degree. C. and forms NbC nanocarbides and a stable essentially single phase fcc austenitic matrix microstructure to give high strength and high creep resistance at these temperatures.

Correlation Study Of Diffenrential Skin Temperatures (DST) For Ovulation Detection Using Infra-Red Thermography

NASA Astrophysics Data System (ADS)

Rao, K. H. S.; Shah, A. v.; Ruedi, B.

1982-11-01

The importance of ovulation time detection in the Practice of Natural Birth Control (NBC) as a contraceptive tool, and for natural/artificial insemination among women having the problem of in-fertility, is well known. The simple Basal Body Temperature (BBT) method of ovulation detection is so far unreliable. A newly proposed Differential Skin Temperature (DST) method may help minimize disturbing physiological effects and improve reliability. This paper explains preliminary results of a detailed correlative study on the DST method, using Infra-Red Thermography (IRT) imaging, and computer analysis techniques. Results obtained with five healthy, normally menstruating women volunteers will be given.

Chronicler's Induction Ceremony

NASA Image and Video Library

2017-05-05

Posters in the NASA News Center at Kennedy Space Center in Florida bear the names and photos of five of the six new honorees added to the facility's "Chroniclers" roll of honor. From left to right are posters featuring Scott Harris, WESH, WKMG and Central Florida News 13; Bill Johnson, NASA Public Affairs; Warren Leary, The New York Times; Bob Murray, WDBO-TV, RCA and United Space Alliance; and Phillip Sandlin, Associated Press photographer. Not pictured is the poster for Bruce Hall, CBS News and NBC News. The Chroniclers program recognizes retirees of the news and communications business who helped spread news of American space exploration from Kennedy Space Center for ten years or more.

The simulated clinical environment: Cognitive and emotional impact among undergraduates.

PubMed

Tremblay, Marie-Laurence; Lafleur, Alexandre; Leppink, Jimmie; Dolmans, Diana H J M

2017-02-01

Simulated clinical immersion (SCI) is used in undergraduate healthcare programs to expose the learner to real-life situations in authentic simulated clinical environments. For novices, the environment in which the simulation occurs can be distracting and stressful, hence potentially compromising learning. This study aims to determine whether SCI (with environment) imposes greater extraneous cognitive load and stress on undergraduate pharmacy students than simulated patients (SP) (without environment). It also aims to explore how features of the simulated environment influence students' perception of learning. In this mixed-methods study, 143 undergraduate pharmacy students experienced both SCI and SP in a crossover design. After the simulations, participants rated their cognitive load and emotions. Thirty-five students met in focus groups to explore their perception of learning in simulation. Intrinsic and extraneous cognitive load and stress scores in SCI were significantly but modestly higher compared to SP. Qualitative findings reveal that the physical environment in SCI generated more stress and affected students? focus. In SP, students concentrated on clinical reasoning. SCI stimulated a focus on data collection but impeded in-depth problem solving processes. The physical environment in simulation influences what and how students learn. SCI was reported as more cognitively demanding than SP. Our findings emphasize the need for the development of adapted instructional design guidelines in simulation for novices.

An investigation of reheat cracking in the weld heat affected zone of type 347 stainless steel

NASA Astrophysics Data System (ADS)

Phung-On, Isaratat

2007-12-01

Reheat cracking has been a persistent problem for welding of many alloys such as the stabilized stainless steels: Types 321 and 347 as well as Cr-Mo-V steels. Similar problem occurs in Ni-base superalloys termed "strain-age cracking". Cracking occurs during the post weld heat treatment. The HAZ is the most susceptible area due to metallurgical reactions in solid state during both heating and cooling thermal cycle. Many investigations have been conducted to understand the RHC mechanism. There is still no comprehensive mechanism to explain its underlying mechanism. In this study, there were two proposed cracking mechanisms. The first is the formation of a PFZ resulting in local weakening and strain localization. The second is the creep-like grain boundary sliding that causes microvoid formation at the grain boundaries and the triple point junctions. Cracking occurs due to the coalescence of the microvoids that form. In this study, stabilized grade stainless steel, Type 347, was selected for investigation of reheat cracking mechanism due to the simplicity of its microstructure and understanding of its metallurgical behavior. The Gleeble(TM) 3800 system was employed due to its capability for precise control of both thermal and mechanical simulation. Cylindrical samples were subjected to thermal cycles for the HAZ simulation followed by PWHT as the reheat cracking test. "Susceptibility C-curves" were plotted as a function of PWHT temperatures and time to failure at applied stress levels of 70% and 80% yield strength. These C-curves show the possible relationship of the reheat cracking susceptibility and carbide precipitation behavior. To identify the mechanism, the sample shape was modified containing two flat surfaces at the center section. These flat surfaces were electro-polished and subjected to the HAZ simulation followed by the placement of the micro-indentation arrays. Then, the reheat cracking test was performed. The cracking mechanism was identified by tracing the shifting of the micro-indentations compared to their original locations. At the 80% stress level, the cracking mechanism was identified as the PFZ weakening, while at the 70% stress as the creep-like grain boundary sliding. A design of experiment (DOE) using a D-optimal design was successfully employed in this study to investigate the effects of microstructures on the reheat cracking susceptibility. The microstructures were modified by heat treatment prior to the reheat cracking test. The grain size and cooling rate were found to have moderate effects on cracking susceptibility. The amount (volume fraction) of MC carbide (NbC) had a significant effect on time to failure. The more NbC formed prior to test, the longer time to failure, and the more resistance to reheat cracking. On the other hand, the amount of GB carbide (M23C6) had an insignificant effect. The statistical interaction between MC carbide with other testing parameters also had strong effect. The PWHT temperature also had significant effect as can be predicted from the susceptibility C-curves. The heat treatment schedules, during cooling and during heating schedules, were also investigated. During cooling schedule was the same schedule done earlier in this study. On the other hand, during heating schedule allowed the sample cool to room temperature prior microstructure modification followed by the reheat cracking test. During heating schedule showed an improvement in resistance to reheat cracking. Microstructure of the crack samples showed the intergranular cracking path and wedge shapes along cracking boundaries. There was also the evidence of grain boundary sliding as a result of the creep-like grain boundary sliding cracking mechanism. SEM showed the intergranular cracking and grain separation with precipitates decorated on the fracture surfaces. The precipitates were identified as Nb-rich, MC carbide (NbC). The fracture surfaces showed micro-ductility and microvoid coalescence. The size of microvoid corresponds to the size of precipitate that forms. In addition, there was intragranular cracking in some location indicating that another failure mechanism may also be possible. It was believed that failure may occur along a precipitate free zone. However, the distinct PFZ could not be detected. A SS-DTA technique was also implemented in order to determine precipitation temperatures of the material. The results showed the possible precipitation temperatures in the range of 850°C to 650°C. However, the results were not confidently reliable due to the small amount of carbide formed that affects the sensitivity of the SS-DTA. A simple grain boundary sliding model was generated proposing that the sliding is operated by the shear stress resulting from the formation of precipitate in the grain interior. Then, the sliding results in the microvoid formation and coalescence followed by cracking. In addition, a simple finite element model was generated to provide the illustration of the shear stress built up by the formation of precipitate. The model showed that shear stress can cause the grain boundary movement/sliding. Based on the results from this study, the recommendation for the selection of post weld heat treatment schedule as well as welding procedures can be determined for the prevention of the reheat cracking. A residual stress should be kept below the critical value during welding and post weld heat treating. The testing procedures used in this study can be applied as the guidelines to conduct the reheat cracking susceptibility test for material selection.

Integrated Clinical Training for Space Flight Using a High-Fidelity Patient Simulator in a Simulated Microgravity Environment

NASA Technical Reports Server (NTRS)

Hurst, Victor; Doerr, Harold K.; Polk, J. D.; Schmid, Josef; Parazynksi, Scott; Kelly, Scott

2007-01-01

This viewgraph presentation reviews the use of telemedicine in a simulated microgravity environment using a patient simulator. For decades, telemedicine techniques have been used in terrestrial environments by many cohorts with varied clinical experience. The success of these techniques has been recently expanded to include microgravity environments aboard the International Space Station (ISS). In order to investigate how an astronaut crew medical officer will execute medical tasks in a microgravity environment, while being remotely guided by a flight surgeon, the Medical Operation Support Team (MOST) used the simulated microgravity environment provided aboard DC-9 aircraft teams of crew medical officers, and remote flight surgeons performed several tasks on a patient simulator.

An intelligent processing environment for real-time simulation

NASA Technical Reports Server (NTRS)

Carroll, Chester C.; Wells, Buren Earl, Jr.

1988-01-01

The development of a highly efficient and thus truly intelligent processing environment for real-time general purpose simulation of continuous systems is described. Such an environment can be created by mapping the simulation process directly onto the University of Alamba's OPERA architecture. To facilitate this effort, the field of continuous simulation is explored, highlighting areas in which efficiency can be improved. Areas in which parallel processing can be applied are also identified, and several general OPERA type hardware configurations that support improved simulation are investigated. Three direct execution parallel processing environments are introduced, each of which greatly improves efficiency by exploiting distinct areas of the simulation process. These suggested environments are candidate architectures around which a highly intelligent real-time simulation configuration can be developed.

From the Underground to the High Ground: The Insurgent Use of Airpower

DTIC Science & Technology

2011-02-16

government. Contents Disclaimer……………………………………………………………………………….....i Contents…………………………………………………………………………………...ii Biography ...19 Biography Lt. Col. John G. Bunnell is a student at Air War College. Prior to Air University, Lt. Col. Bunnell served as an F...The Jerusalem Post, 19 April 2005. 45 Lisa Myers, “Hezbollah drone threatens Israel,” NBC Nightly News, 4 December 2005. 46 Roee Nahmias

Methods for making a porous nuclear fuel element

DOEpatents

Youchison, Dennis L; Williams, Brian E; Benander, Robert E

2014-12-30

Porous nuclear fuel elements for use in advanced high temperature gas-cooled nuclear reactors (HTGR's), and to processes for fabricating them. Advanced uranium bi-carbide, uranium tri-carbide and uranium carbonitride nuclear fuels can be used. These fuels have high melting temperatures, high thermal conductivity, and high resistance to erosion by hot hydrogen gas. Tri-carbide fuels, such as (U,Zr,Nb)C, can be fabricated using chemical vapor infiltration (CVI) to simultaneously deposit each of the three separate carbides, e.g., UC, ZrC, and NbC in a single CVI step. By using CVI, the nuclear fuel may be deposited inside of a highly porous skeletal structure made of, for example, reticulated vitreous carbon foam.

Cold resistant nickel-alloy steel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Legostaev, Yu.L.; Karchevskaya, N.I.; Karchevnikov, V.P.

1988-05-01

Low-alloy cold-resistant steel 10GNB was developed for the construction of ships and floating drill rigs. The optimal heat-treatment regime for the steel was refinement. Reducing the carbon content improved its weldability and toughness properties. Optical metallography and electron microscopy established that the optimal structure was a tempered martensitic-bainitic mixture with uniformly distributed particles of disperse special niobium carbides NbC. The substructure and the processes of carbide and carbonitride phase segregation were studied by transmission and extraction electron microscopy. In mechanical tests the steel exhibited high resistance to brittle failure. In terms of corrosion resistance the steel corresponds to the requirementsmore » set forth for shipbuilding steels.« less

Cleveland Clinic television series enhances branding in active market.

PubMed

Rees, T

2001-01-01

"Medical Miracles" premiered April 26. It is an information-packed series of programs showcasing The Cleveland Clinic's advanced medical practices. The Cleveland Clinic teamed with local NBC-affiliate, WKYC to develop half-hour shows on topics including neuro-sciences, orthopedics, eye, heart, pediatrics and cancer. As of this writing, three of the half-hour shows already have aired. They will resume in September, October and November, following a summer break. The collaboration is a healthy prospect all the way around. For Cleveland Clinic, it provides highly credible visibility in a competitive marketplace. And, according to WKYC president and general manager, Brooke Spectorsky, " Medical news and information is a high priority among our viewers."

Microstructures evolution and physical properties of laser induced NbC modified nanocrystalline composites

NASA Astrophysics Data System (ADS)

Li, Jianing; Liu, Kegao; Yuan, Xingdong; Shan, Feihu; Zhang, Bolun; Wang, Zhe; Xu, Wenzhuo; Zhang, Zheng; An, Xiangchen

2017-10-01

The nanoscale quasicrystals (NQs), amorphous and ultrafine nanocrystals (UNs) modified hard composites are produced by laser cladding (LC) of the Ni60A-TiC-NbC-Sb mixed powders on the additive manufacturing (AM) TA1 titanium alloy. The LC technique is favorable to formations of icosahedral quasicrystals (I-phase) with five-fold symmetry due to its rapid cooling and solidification characteristics. The formation mechanism of this I-phase is explained here. Under the actions of NQs, amorphous and UNs, such LC composites exhibited an extremely high micro-hardness. UNs may also intertwin with amorphous, forming yarn-shape materials. This research provides essential theoretical basis to improve the quality of laser-treated composites.

Chronicler's Induction Ceremony

NASA Image and Video Library

2017-05-05

Friends, family members and colleagues of former NASA Public Affairs team members and space journalists gather in the NASA News Center at Kennedy Space Center in Florida for a ceremony in which six new honorees were added to the "Chroniclers" roll of honor. The Chroniclers program recognizes retirees of the news and communications business who helped spread news of American space exploration from Kennedy Space Center for ten years or more. The 2017 Chroniclers are Bruce Hall, CBS News and NBC News; Scott Harris, WESH, WKMG and Central Florida News 13; Bill Johnson, NASA Public Affairs; Warren Leary, The New York Times; Bob Murray, WDBO-TV, RCA and United Space Alliance; and Phillip Sandlin, Associated Press photographer.

Cybersickness and Anxiety During Simulated Motion: Implications for VRET.

PubMed

Bruck, Susan; Watters, Paul

2009-01-01

Some clinicians have suggested using virtual reality environments to deliver psychological interventions to treat anxiety disorders. However, given a significant body of work on cybersickness symptoms which may arise in virtual environments - especially those involving simulated motion - we tested (a) whether being exposed to a virtual reality environment alone causes anxiety to increase, and (b) whether exposure to simulated motion in a virtual reality environment increases anxiety. Using a repeated measures design, we used Kim's Anxiety Scale questionnaire to compare baseline anxiety, anxiety after virtual environment exposure, and anxiety after simulated motion. While there was no significant effect on anxiety for being in a virtual environment with no simulated motion, the introduction of simulated motion caused anxiety to significantly increase, but not to a severe or extreme level. The implications of this work for virtual reality exposure therapy (VRET) are discussed.

A Comparison of Students' Conceptual Understanding of Electric Circuits in Simulation Only and Simulation-Laboratory Contexts

ERIC Educational Resources Information Center

Jaakkola, Tomi; Nurmi, Sami; Veermans, Koen

2011-01-01

The aim of this experimental study was to compare learning outcomes of students using a simulation alone (simulation environment) with outcomes of those using a simulation in parallel with real circuits (combination environment) in the domain of electricity, and to explore how learning outcomes in these environments are mediated by implicit (only…

Full immersion simulation: validation of a distributed simulation environment for technical and non-technical skills training in Urology.

PubMed

Brewin, James; Tang, Jessica; Dasgupta, Prokar; Khan, Muhammad S; Ahmed, Kamran; Bello, Fernando; Kneebone, Roger; Jaye, Peter

2015-07-01

To evaluate the face, content and construct validity of the distributed simulation (DS) environment for technical and non-technical skills training in endourology. To evaluate the educational impact of DS for urology training. DS offers a portable, low-cost simulated operating room environment that can be set up in any open space. A prospective mixed methods design using established validation methodology was conducted in this simulated environment with 10 experienced and 10 trainee urologists. All participants performed a simulated prostate resection in the DS environment. Outcome measures included surveys to evaluate the DS, as well as comparative analyses of experienced and trainee urologist's performance using real-time and 'blinded' video analysis and validated performance metrics. Non-parametric statistical methods were used to compare differences between groups. The DS environment demonstrated face, content and construct validity for both non-technical and technical skills. Kirkpatrick level 1 evidence for the educational impact of the DS environment was shown. Further studies are needed to evaluate the effect of simulated operating room training on real operating room performance. This study has shown the validity of the DS environment for non-technical, as well as technical skills training. DS-based simulation appears to be a valuable addition to traditional classroom-based simulation training. © 2014 The Authors BJU International © 2014 BJU International Published by John Wiley & Sons Ltd.

Comparative molecular analyses of select pH- and osmoregulatory genes in three freshwater crayfish Cherax quadricarinatus, C. destructor and C. cainii.

PubMed

Ali, Muhammad Y; Pavasovic, Ana; Dammannagoda, Lalith K; Mather, Peter B; Prentis, Peter J

2017-01-01

Systemic acid-base balance and osmotic/ionic regulation in decapod crustaceans are in part maintained by a set of transport-related enzymes such as carbonic anhydrase (CA), Na + /K + -ATPase (NKA), H + -ATPase (HAT), Na + /K + /2Cl - cotransporter (NKCC), Na + /Cl - /HCO[Formula: see text] cotransporter (NBC), Na + /H + exchanger (NHE), Arginine kinase (AK), Sarcoplasmic Ca +2 -ATPase (SERCA) and Calreticulin (CRT). We carried out a comparative molecular analysis of these genes in three commercially important yet eco-physiologically distinct freshwater crayfish , Cherax quadricarinatus, C. destructor and C. cainii , with the aim to identify mutations in these genes and determine if observed patterns of mutations were consistent with the action of natural selection. We also conducted a tissue-specific expression analysis of these genes across seven different organs, including gills, hepatopancreas, heart, kidney, liver, nerve and testes using NGS transcriptome data. The molecular analysis of the candidate genes revealed a high level of sequence conservation across the three Cherax sp. Hyphy analysis revealed that all candidate genes showed patterns of molecular variation consistent with neutral evolution. The tissue-specific expression analysis showed that 46% of candidate genes were expressed in all tissue types examined, while approximately 10% of candidate genes were only expressed in a single tissue type. The largest number of genes was observed in nerve (84%) and gills (78%) and the lowest in testes (66%). The tissue-specific expression analysis also revealed that most of the master genes regulating pH and osmoregulation (CA, NKA, HAT, NKCC, NBC, NHE) were expressed in all tissue types indicating an important physiological role for these genes outside of osmoregulation in other tissue types. The high level of sequence conservation observed in the candidate genes may be explained by the important role of these genes as well as potentially having a number of other basic physiological functions in different tissue types.

Comparison of load distribution for implant overdenture attachments.

PubMed

Porter, Joseph A; Petropoulos, Vicki C; Brunski, John B

2002-01-01

The aim of this study was to compare the force and moment distributions that develop on different implant overdenture attachments when vertical compressive forces are applied to an implant-retained overdenture. The following attachments were examined: Nobel Biocare bar and clip (NBC), Nobel Biocare standard ball (NSB), Nobel Biocare 2.25-mm-diameter ball (NB2), Zest Anchor Advanced Generation (ZAAG), Sterngold ERA white (SEW), Sterngold ERA orange (SEO), Compliant Keeper System with titanium shims (CK-Ti), Compliant Keeper System with black nitrile 2SR90 sleeve rings (CK-70), and Compliant Keeper System with clear silicone 2SR90 sleeve rings (CK-90). The attachments were tested using custom strain-gauged abutments and 2 Brånemark System implants placed in a test model. Each attachment type had one part embedded in a denture-like housing and the other part (the abutment) screwed into the implants. Compressive static loads of 100 N were applied (1) bilaterally, over the distal midline (DM); (2) unilaterally, over the right implant (RI); (3) unilaterally, over the left implant (LI); and (4) between implants in the mid-anterior region (MA). Both the force and bending moment on each implant were recorded for each loading location and attachment type. Results were analyzed using 2-way analysis of variance and the Duncan multiple-range test. Both loading location and attachment type were statistically significant factors (P < .05). In general, the force and moment on an implant were greater when the load was applied directly over the implant or at MA. While not significant at every loading location, the largest implant forces tended to occur with ZAAG attachments; the smallest were found with the SEW, the SEO, the NSB, the CK-70, and the CK-90. Typically, higher moments existed for NBC and ZAAG, while lower moments existed for SEW, SEO, NSB, CK-90, and CK-70. For different loading locations, significant differences were found among the different overdenture attachment systems.

A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31

PubMed Central

Lipovich, Leonard; Lynch, Eric D; Lee, Ming K; King, Mary-Claire

2001-01-01

Background: Sodium bicarbonate cotransporter (NBC) genes encode proteins that execute coupled Na+ and HCO3- transport across epithelial cell membranes. We report the discovery, characterization, and genomic context of a novel human NBC-like gene, SLC4A9, on chromosome 5q31. Results: SLC4A9 was initially discovered by genomic sequence annotation and further characterized by sequencing of long-insert cDNA library clones. The predicted protein of 990 amino acids has 12 transmembrane domains and high sequence similarity to other NBCs. The 23-exon gene has 14 known mRNA isoforms. In three regions, mRNA sequence variation is generated by the inclusion or exclusion of portions of an exon. Noncoding SLC4A9 cDNAs were recovered multiple times from different libraries. The 3' untranslated region is fragmented into six alternatively spliced exons and contains expressed Alu, LINE and MER repeats. SLC4A9 has two alternative stop codons and six polyadenylation sites. Its expression is largely restricted to the kidney. In silico approaches were used to characterize two additional novel SLC4A genes and to place SLC4A9 within the context of multiple paralogous gene clusters containing members of the epidermal growth factor (EGF), ankyrin (ANK) and fibroblast growth factor (FGF) families. Seven human EGF-SLC4A-ANK-FGF clusters were found. Conclusion: The novel sodium bicarbonate cotransporter-like gene SLC4A9 demonstrates abundant alternative mRNA processing. It belongs to a growing class of functionally diverse genes characterized by inefficient highly variable splicing. The evolutionary history of the EGF-SLC4A-ANK-FGF gene clusters involves multiple rounds of duplication, apparently followed by large insertions and deletions at paralogous loci and genome-wide gene shuffling. PMID:11305939

Selective recharge and isotopic composition of shallow groundwater within temperate, epigenic carbonate aquifers

NASA Astrophysics Data System (ADS)

Florea, Lee J.

2013-05-01

This paper considers the variation of δ18O and δ2H (VSMOW) in precipitation and shallow groundwater from carbonate aquifers that lend insight into the source and timing of recharge within temperate, epigenic karst. The shallow groundwater collected during 2010 and 2011 at Stream Cave (SC) and Natural Bridge Caverns (NBC) represent one input to and the primary output from the Redmond Creek karst aquifer in the Cumberland Plateau of southeast Kentucky, respectively. These data are compared with the isotopic composition of concurrent samples of precipitation from the same watershed that covers some 1900 ha. Values of δ18O and δ2H at SC and NBC are statistically similar and cluster at the midpoint of the local meteoric water line. These values remain surprisingly constant despite seasonal changes in temperature regimens and discharge. Samples in 2012 from regional springs that include Redmond Creek are more depleted in the heavier isotope and similarly stable despite coming from aquifers of a range of sizes and physical characteristics. Applying a Priestly-Taylor model for daily values of potential evapotranspiration, only 43% of the 1.10 m of precipitation in the 2010-2011 dataset remains as potential recharge, primarily during cooler months with lower solar insolation. Weighting δ18O and δ2H values of precipitation by potential recharge creates a better match with the isotopic composition of shallow groundwater than by weighting by precipitation amount. The isotopic composition and deuterium excess of precipitation samples are directly and inversely proportional to temperature, respectively. Deuterium excess in this study and displays intra- and inter-annual variation that ranges from a minimum of +11.1‰ to a maximum of +29.5‰ that demonstrate the higher-than-average deuterium excess in greater Appalachia and the shifting latitude of moisture sources, including a significant winter component of re-evaporated, continental moisture.

Microstructural characterisation of friction stir welding joints of mild steel to Ni-based alloy 625

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodriguez, J.; University of Campinas; Ramirez, A.J., E-mail: ramirezlondono.1@osu.edu

2015-12-15

In this study, 6-mm-thick mild steel and Ni-based alloy 625 plates were friction stir welded using a tool rotational speed of 300 rpm and a travel speed of 100 mm·min{sup −1}. A microstructural characterisation of the dissimilar butt joint was performed using optical microscopy, scanning and transmission electron microscopy, and energy dispersive X-ray spectroscopy (XEDS). Six different weld zones were found. In the steel, the heat-affected zone (HAZ) was divided into three zones and was composed of ferrite, pearlite colonies with different morphologies, degenerated regions of pearlite and allotriomorphic and Widmanstätten ferrite. The stir zone (SZ) of the steel showedmore » a coarse microstructure consisting of allotriomorphic and Widmanstätten ferrite, degenerate pearlite and MA constituents. In the Ni-based alloy 625, the thermo-mechanically affected zone (TMAZ) showed deformed grains and redistribution of precipitates. In the SZ, the high deformation and temperature produced a recrystallised microstructure, as well as fracture and redistribution of MC precipitates. The M{sub 23}C{sub 6} precipitates, present in the base material, were also redistributed in the stir zone of the Ni-based alloy. TMAZ in the steel and HAZ in the Ni-based alloy could not be identified. The main restorative mechanisms were discontinuous dynamic recrystallisation in the steel, and discontinuous and continuous dynamic recrystallisation in the Ni-based alloy. The interface region between the steel and the Ni-based alloy showed a fcc microstructure with NbC carbides and an average length of 2.0 μm. - Highlights: • Comprehensive microstructural characterisation of dissimilar joints of mild steel to Ni-based alloy • Friction stir welding of joints of mild steel to Ni-based alloy 625 produces sound welds. • The interface region showed deformed and recrystallised fcc grains with NbC carbides and a length of 2.0 μm.« less

Violence in television commercials during nonviolent programming. The 1996 Major League Baseball playoffs.

PubMed

Anderson, C

1997-10-01

To identify the frequency of violent television commercials aired during major league baseball playoffs, traditionally thought to be a family-oriented viewing time. All 6 World Series games televised on the Fox Television Network (Fox), all 5 American League Championship Series playoff games televised by the National Broadcasting Company (NBC), and 4 first-round playoff games televised by ESPN Sports Television Network (ESPN) were videotaped in October 1996. During the 15 televised games reviewed, 104 (6.8%) of the 1528 commercials contained violent content. Sixty-one commercials (10 per game) that included violent interactions were noted during the World Series, 30 (6 per game) during the American League Championship Series, and 13 (3 per game) during the 4 first-round playoff games for a total of 104. In these 104 violent commercials, 69 contained at least 1 violent act, 90 contained at least 1 violent threat, and 27 contained evidence of at least 1 violent consequence. Seventy (67.3%) of the violent commercials were promotions for television programs, 7 (6.7%) were cable television program advertisements, and 20 (19.2%) were big-screen movie promotions. Twenty (71.4%) of 28 big-screen movie promotions were violent. Twenty-two (21.2%) of the 104 violent commercials and 7 "nonviolent" commercials contained blood or other graphic content, all of which were televised during the Fox presentation of the World Series. Fox also accounted for all 24 violent commercials that used a knife. Guns were involved in 25 violent commercials on NBC (5.0 per game), in 20 on Fox (3.33 per game), and in 7 on ESPN (1.75 per game). Overt violent content in commercials during the 1996 major league playoffs was common and consisted mainly of promotions for television programs and big-screen movies. It is counterintuitive to find such commercials in nonviolent programming and makes it difficult for parents to avoid exposing their children to this form of violence.

Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.

PubMed

Sugiura, Shozo H; Roy, Prabir K; Ferraris, Ronaldo P

2006-10-01

Oxynticopeptic cells of fish stomach are thought to secrete less acid than the specialized parietal cells of mammalian stomach. Gastric acidity, however, has not been directly compared between fish and mammals. We therefore fed rainbow trout and rats the same meal, and found that the lowest postprandial pH of trout stomach was 2.7, which was only transiently sustained for 1 h, whereas that of rat stomach was 1.3, which was sustained for 3 h. Postprandial pH of the small intestine was slightly higher in trout (approximately 8.0) than in rats (approximately 7.6), but pH of the large intestine was similar (approximately 8.0). Addition of acids to fish feeds, in an attempt to aid the weak acidity of fish stomach, has been known to improve phosphorus digestibility, but its physiological effect on fish stomach is not known. Exogenous acids did improve phosphorus digestibility but also decreased steady-state mRNA expression of trout H(+)/K(+)-ATPase (ATP4A, the proton pump) as well as Na(+)/bicarbonate cotransporter (NBC), and had no effect on gastrin-like mRNA and somastostatin (SST) mRNA abundance. Gastrin-like mRNA and SST-2 mRNA were equally distributed between corpus and antrum. ATP4A mRNA and NBC mRNA were in the corpus, whereas SST-1 mRNA was in the antrum. Trout gastrin-like EST had modest homology to halibut and pufferfish gastrin, whereas trout ATP4A mRNA had > or = 95% amino acid homology with mammalian, Xenopus and flounder ATP4A. Although ATP4A seems highly conserved among vertebrates, gastric acidity is much less in trout than in rats, explaining the low digestibility of bone phosphorus, abundant in fish diets. Dietary acidification does not reduce acidity enough to markedly improve phosphorus digestibility, perhaps because exogenous acids may inhibit endogenous acid production.

Structural modulation and luminescent properties of four CdII coordination architectures based on 3-(pyridin-4-yl)-5-(pyrazin-2-yl)-1H-1,2,4-triazole and flexible/rigid dicarboxylate ligands

NASA Astrophysics Data System (ADS)

Xia, Liang; Dong, Wen-Wen; Ye, Xiao; Zhao, Jun; Li, Dong-Sheng

2016-10-01

To systematically investigate the influence of the flexible or rigid auxiliary ligands on the structures and properties of transition metal compounds, we synthesized four new d10 coordination polymers (CPs) from 3-(pyridin-4-yl)-5-(pyrazin-2-yl)-1H-1,2,4-triazole (4-Hpzpt) and flexible/rigid dicarboxylate ligands, [Cd(4-pzpt)2]n (1), [Cd3(4-pzpt)2(suc)2]n (2), [Cd2(4-Hpzpt)(nbc)2(H2O)]n (3) and {[Cd2(4-pzpt)2(tfbdc)(H2O)4]·H2O}n (4) (H2suc=1,2-ethanedicarboxylic acid, H2nbc=hthalene-1,4-dicarboxylic acid, H2tfbdc =2,3,5,6-tetrafluoroterephthalic acid). Single crystal X-ray analysis indicates that compound 1 shows a 44-sql layer, which is extended to a 3D network via nonclassical C-H…N hydrogen bonds. Compound 2 possesses a 6-connected pcu-4120.63 net composed of trinuclear CdII-clusters. Compound 3 represents a rare 3D (3,4,4,5)-connected topology with a Schläfli symbol of (4·6·7)(4·53·72)(53·6·7·9)(42·55·6·72). Compound 4 exhibits a 2D+2D→2D parallel interpenetrated 63-hcb network. The adjacent 2D networks are interdigitated with each other to form the resulting 3D supramolecular architecture through classical O-H…N and O-H…O hydrogen bonds. Structural diversities indicate that the nature of flexible/rigid-dicarboxlates plays crucial roles in modulating structures of these compounds. Moreover, the luminescent properties of them have been briefly investigated.

A comparison of the accuracy of intraoral scanners using an intraoral environment simulator.

PubMed

Park, Hye-Nan; Lim, Young-Jun; Yi, Won-Jin; Han, Jung-Suk; Lee, Seung-Pyo

2018-02-01

The aim of this study was to design an intraoral environment simulator and to assess the accuracy of two intraoral scanners using the simulator. A box-shaped intraoral environment simulator was designed to simulate two specific intraoral environments. The cast was scanned 10 times by Identica Blue (MEDIT, Seoul, South Korea), TRIOS (3Shape, Copenhagen, Denmark), and CS3500 (Carestream Dental, Georgia, USA) scanners in the two simulated groups. The distances between the left and right canines (D3), first molars (D6), second molars (D7), and the left canine and left second molar (D37) were measured. The distance data were analyzed by the Kruskal-Wallis test. The differences in intraoral environments were not statistically significant ( P >.05). Between intraoral scanners, statistically significant differences ( P <.05) were revealed by the Kruskal-Wallis test with regard to D3 and D6. No difference due to the intraoral environment was revealed. The simulator will contribute to the higher accuracy of intraoral scanners in the future.

The Simultaneous Production Model; A Model for the Construction, Testing, Implementation and Revision of Educational Computer Simulation Environments.

ERIC Educational Resources Information Center

Zillesen, Pieter G. van Schaick

This paper introduces a hardware and software independent model for producing educational computer simulation environments. The model, which is based on the results of 32 studies of educational computer simulations program production, implies that educational computer simulation environments are specified, constructed, tested, implemented, and…

Simulating high frequency water quality monitoring data using a catchment runoff attenuation flux tool (CRAFT).

PubMed

Adams, Russell; Quinn, Paul F; Perks, Matthew; Barber, Nicholas J; Jonczyk, Jennine; Owen, Gareth J

2016-12-01

High resolution water quality data has recently become widely available from numerous catchment based monitoring schemes. However, the models that can reproduce time series of concentrations or fluxes have not kept pace with the advances in monitoring data. Model performance at predicting phosphorus (P) and sediment concentrations has frequently been poor with models not fit for purpose except for predicting annual losses. Here, the data from the Eden Demonstration Test Catchments (DTC) project have been used to calibrate the Catchment Runoff Attenuation Flux Tool (CRAFT), a new, parsimonious model developed with the aim of modelling both the generation and attenuation of nutrients and sediments in small to medium sized catchments. The CRAFT has the ability to run on an hourly timestep and can calculate the mass of sediments and nutrients transported by three flow pathways representing rapid surface runoff, fast subsurface drainage and slow groundwater flow (baseflow). The attenuation feature of the model is introduced here; this enables surface runoff and contaminants transported via this pathway to be delayed in reaching the catchment outlet. It was used to investigate some hypotheses of nutrient and sediment transport in the Newby Beck Catchment (NBC) Model performance was assessed using a suite of metrics including visual best fit and the Nash-Sutcliffe efficiency. It was found that this approach for water quality models may be the best assessment method as opposed to using a single metric. Furthermore, it was found that, when the aim of the simulations was to reproduce the time series of total P (TP) or total reactive P (TRP) to get the best visual fit, that attenuation was required. The model will be used in the future to explore the impacts on water quality of different mitigation options in the catchment; these will include attenuation of surface runoff. Copyright © 2016 Elsevier B.V. All rights reserved.

Comparative Study of the Effectiveness of Three Learning Environments: Hyper-Realistic Virtual Simulations, Traditional Schematic Simulations and Traditional Laboratory

ERIC Educational Resources Information Center

Martinez, Guadalupe; Naranjo, Francisco L.; Perez, Angel L.; Suero, Maria Isabel; Pardo, Pedro J.

2011-01-01

This study compared the educational effects of computer simulations developed in a hyper-realistic virtual environment with the educational effects of either traditional schematic simulations or a traditional optics laboratory. The virtual environment was constructed on the basis of Java applets complemented with a photorealistic visual output.…

The Development and Evaluation of a Computer-Simulated Science Inquiry Environment Using Gamified Elements

ERIC Educational Resources Information Center

Tsai, Fu-Hsing

2018-01-01

This study developed a computer-simulated science inquiry environment, called the Science Detective Squad, to engage students in investigating an electricity problem that may happen in daily life. The environment combined the simulation of scientific instruments and a virtual environment, including gamified elements, such as points and a story for…

Simulation fails to replicate stress in trainees performing a technical procedure in the clinical environment.

PubMed

Baker, B G; Bhalla, A; Doleman, B; Yarnold, E; Simons, S; Lund, J N; Williams, J P

2017-01-01

Simulation-based training (SBT) has become an increasingly important method by which doctors learn. Stress has an impact upon learning, performance, technical, and non-technical skills. However, there are currently no studies that compare stress in the clinical and simulated environment. We aimed to compare objective (heart rate variability, HRV) and subjective (state trait anxiety inventory, STAI) measures of stress theatre with a simulated environment. HRV recordings were obtained from eight anesthetic trainees performing an uncomplicated rapid sequence induction at pre-determined procedural steps using a wireless Polar RS800CX monitor © in an emergency theatre setting. This was repeated in the simulated environment. Participants completed an STAI before and after the procedure. Eight trainees completed the study. The theatre environment caused an increase in objective stress vs baseline (p = .004). There was no significant difference between average objective stress levels across all time points (p = .20) between environments. However, there was a significant interaction between the variables of objective stress and environment (p = .045). There was no significant difference in subjective stress (p = .27) between environments. Simulation was unable to accurately replicate the stress of the technical procedure. This is the first study that compares the stress during SBT with the theatre environment and has implications for the assessment of simulated environments for use in examinations, rating of technical and non-technical skills, and stress management training.

Development of an Interactive Augmented Environment and Its Application to Autonomous Learning for Quadruped Robots

NASA Astrophysics Data System (ADS)

Kobayashi, Hayato; Osaki, Tsugutoyo; Okuyama, Tetsuro; Gramm, Joshua; Ishino, Akira; Shinohara, Ayumi

This paper describes an interactive experimental environment for autonomous soccer robots, which is a soccer field augmented by utilizing camera input and projector output. This environment, in a sense, plays an intermediate role between simulated environments and real environments. We can simulate some parts of real environments, e.g., real objects such as robots or a ball, and reflect simulated data into the real environments, e.g., to visualize the positions on the field, so as to create a situation that allows easy debugging of robot programs. The significant point compared with analogous work is that virtual objects are touchable in this system owing to projectors. We also show the portable version of our system that does not require ceiling cameras. As an application in the augmented environment, we address the learning of goalie strategies on real quadruped robots in penalty kicks. We make our robots utilize virtual balls in order to perform only quadruped locomotion in real environments, which is quite difficult to simulate accurately. Our robots autonomously learn and acquire more beneficial strategies without human intervention in our augmented environment than those in a fully simulated environment.

Tank Gunnery Analysis for Developing a Tank Crew Training Data Base

DTIC Science & Technology

1978-08-01

Tarots 4 1099.33 50.10 001 N(A) - Error 27 51-837 AB - Comeanys X Table 2 58.323 2.36 N.S. AC - CGmanvs X Targets 8 32.114 1.46 N.S. C - Table X Taretq 4...92.146 4.43 • .01 NB(A - Err r 27 24.699 NC(A) - Error 106 21.947 ABC - Companys X Table V Tarot ........ 20.971 .4gI .. L NBC(A) - Error 10 _ 20.789...Meters) Tarot Mode Opening Tirm Plits N iaraets 770-81Q S B 7.3 86 119 D (1024) m B (17.8) (75) 32 11 A (1230) S P (16.6) (68) 31 E y 1610 m p 12.1 37

Mechanisms of bicarbonate secretion: lessons from the airways.

PubMed

Bridges, Robert J

2012-08-01

Early studies showed that airway cells secrete HCO(3)(-) in response to cAMP-mediated agonists and HCO(3)(-) secretion was impaired in cystic fibrosis (CF). Studies with Calu-3 cells, an airway serous model with high expression of CFTR, also show the secretion of HCO(3)(-) when cells are stimulated with cAMP-mediated agonists. Activation of basolateral membrane hIK-1 K(+) channels inhibits HCO(3)(-) secretion and stimulates Cl(-) secretion. CFTR mediates the exit of both HCO(3)(-) and Cl(-) across the apical membrane. Entry of HCO(3)(-) on a basolateral membrane NBC or Cl(-) on the NKCC determines which anion is secreted. Switching between these two secreted anions is determined by the activity of hIK-1 K(+) channels.

Methods for manufacturing porous nuclear fuel elements for high-temperature gas-cooled nuclear reactors

DOEpatents

Youchison, Dennis L [Albuquerque, NM; Williams, Brian E [Pocoima, CA; Benander, Robert E [Pacoima, CA

2010-02-23

Methods for manufacturing porous nuclear fuel elements for use in advanced high temperature gas-cooled nuclear reactors (HTGR's). Advanced uranium bi-carbide, uranium tri-carbide and uranium carbonitride nuclear fuels can be used. These fuels have high melting temperatures, high thermal conductivity, and high resistance to erosion by hot hydrogen gas. Tri-carbide fuels, such as (U,Zr,Nb)C, can be fabricated using chemical vapor infiltration (CVI) to simultaneously deposit each of the three separate carbides, e.g., UC, ZrC, and NbC in a single CVI step. By using CVI, a thin coating of nuclear fuel may be deposited inside of a highly porous skeletal structure made, for example, of reticulated vitreous carbon foam.

Porous nuclear fuel element for high-temperature gas-cooled nuclear reactors

DOEpatents

Youchison, Dennis L [Albuquerque, NM; Williams, Brian E [Pacoima, CA; Benander, Robert E [Pacoima, CA

2011-03-01

Porous nuclear fuel elements for use in advanced high temperature gas-cooled nuclear reactors (HTGR's), and to processes for fabricating them. Advanced uranium bi-carbide, uranium tri-carbide and uranium carbonitride nuclear fuels can be used. These fuels have high melting temperatures, high thermal conductivity, and high resistance to erosion by hot hydrogen gas. Tri-carbide fuels, such as (U,Zr,Nb)C, can be fabricated using chemical vapor infiltration (CVI) to simultaneously deposit each of the three separate carbides, e.g., UC, ZrC, and NbC in a single CVI step. By using CVI, the nuclear fuel may be deposited inside of a highly porous skeletal structure made of, for example, reticulated vitreous carbon foam.

Porous nuclear fuel element with internal skeleton for high-temperature gas-cooled nuclear reactors

DOEpatents

Youchison, Dennis L.; Williams, Brian E.; Benander, Robert E.

2013-09-03

Porous nuclear fuel elements for use in advanced high temperature gas-cooled nuclear reactors (HTGR's), and to processes for fabricating them. Advanced uranium bi-carbide, uranium tri-carbide and uranium carbonitride nuclear fuels can be used. These fuels have high melting temperatures, high thermal conductivity, and high resistance to erosion by hot hydrogen gas. Tri-carbide fuels, such as (U,Zr,Nb)C, can be fabricated using chemical vapor infiltration (CVI) to simultaneously deposit each of the three separate carbides, e.g., UC, ZrC, and NbC in a single CVI step. By using CVI, the nuclear fuel may be deposited inside of a highly porous skeletal structure made of, for example, reticulated vitreous carbon foam.

Antimicrobial effects of various nutrient electrolyte beverages. Final report, 1981-1982

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rowley, D.B.; Johnson, D.; Shattuck, G.E.

The purpose of this study was to determine if Staphylococcus aureus, Saccharomyces cerevisiae, or the mold Aspergillus flavus could survive and muliply in Quenchade, Gatorade, and other electrolyte beverages to the point of creating a stability problem or a health hazard to NBC encapsulated personnel. During periods longer than 6 h, such individuals may need liquid energy and electrolyte supplements (Na+ and Cl-) capable of being consumed through the drinking tube of their protective mask. Although S. aureus was inactivated due to the low pH (ca. f3.0) of the electrolyte beverages, antimicrobial agents sodium benzoate or potassium sorbate had tomore » be added to prevent the multiplication of yeast and mold.« less

STS-99 Flight Day Highlights and Crew Activities Report

NASA Technical Reports Server (NTRS)

2000-01-01

Live footage shows the Blue Team (second of the dual shift crew), Dominic L. Pudwill Gorie, Janice E. Voss and Mamoru Mohri, beginning the first mapping swath covering a 140-mile-wide path. While Mohri conducts mapping operations, Voss and Gorie are seen participating in a news conference with correspondents from NBC and CNN. The Red Team (first of the dual shift crew), Kevin R. Kregel, Janet L. Kavandi and Gerhard P.J. Thiele, relieves the Blue Team and are seen continuing the mapping operations for this around the clock Shuttle Radar Topography Mission (SRTM). Commander Kregel is shown performing boom (mass) durability tests, calibrating the EarthCam Payload, and speaking with the Launch Control Center (LCC) about trouble shooting a bracket for better camera angle.

Chronicler's Induction Ceremony

NASA Image and Video Library

2017-05-05

Bill Johnson, left, retired NASA chief of Media Services at Kennedy Space Center in Florida, is congratulated by NASA Public Information Specialist George Diller during a ceremony for six new honorees added to the "Chroniclers" roll of honor in the NASA News Center. Johnson, whose career at Kennedy spanned more than 45 years, was one of the six added to the Chroniclers list. Also added were Bruce Hall, CBS News and NBC News; Scott Harris, WESH, WKMG and Central Florida News 13; Warren Leary, The New York Times; Bob Murray, WDBO-TV, RCA and United Space Alliance; and Phillip Sandlin, Associated Press photographer. The Chroniclers program recognizes retirees of the news and communications business who helped spread news of American space exploration from Kennedy Space Center for ten years or more.

Comparing Local TV News with National TV News in Cancer Coverage: An Exploratory Content Analysis

PubMed Central

Lee, Chul-joo; Long, Marilee; Slater, Michael D.; Song, Wen

2014-01-01

We compared local TV news with national TV news in terms of cancer coverage using a nationally representative sample of local nightly TV and national network TV (i.e., ABC, CBS, NBC, and CNN) cancer news stories that aired during 2002 and 2003. Compared to national TV news, local TV cancer stories were (a) much shorter in length, (b) less likely to report on cancer prevention (i.e., preventive behaviors and screening tests), and (c) less likely to reference national organizations (i.e., NCI, ACS, NIH, CDC, FDA) that have made clear recommendations about ways to prevent cancer. The implications of these findings for health communication research and cancer education were discussed. PMID:24750022

Integrated Battlefield Effects Research for the National Training Center. Appendix B. Requirements Design Specification for the Addition of Nuclear and Chemical Capabilities to the National Training Center (NTC) Core Instrumentation Subsystem (CIS)

DTIC Science & Technology

1984-12-31

NiGjA0’NG S04EDULE suniitd N /A since Unclassified A OER04ORMING ORG.AP4IMIOIJ REPORT NUMBER(S) S. MONITORING ORGAzuZ.lION AEPORT NI.JMSEMR(S) R:LJF-84...foot-poad-toro~ Joule (J) 1.355 I1I galo0 (U.S. Liquid) setar ( I( 3.735 412 xI -), inch eater (a) 2.540000 N I - jrk joule M) [.am 000 x 4. joule...Division (How to Fight), FM 11-50, 8. Military Symbols, FM 21-30. 9. NBC (Nuclear, Biological and Chemical) Defense, FM 21-40. N " 10. Combat Communications

A comparison of the accuracy of intraoral scanners using an intraoral environment simulator

PubMed Central

Park, Hye-Nan; Lim, Young-Jun; Yi, Won-Jin

2018-01-01

PURPOSE The aim of this study was to design an intraoral environment simulator and to assess the accuracy of two intraoral scanners using the simulator. MATERIALS AND METHODS A box-shaped intraoral environment simulator was designed to simulate two specific intraoral environments. The cast was scanned 10 times by Identica Blue (MEDIT, Seoul, South Korea), TRIOS (3Shape, Copenhagen, Denmark), and CS3500 (Carestream Dental, Georgia, USA) scanners in the two simulated groups. The distances between the left and right canines (D3), first molars (D6), second molars (D7), and the left canine and left second molar (D37) were measured. The distance data were analyzed by the Kruskal-Wallis test. RESULTS The differences in intraoral environments were not statistically significant (P>.05). Between intraoral scanners, statistically significant differences (P<.05) were revealed by the Kruskal-Wallis test with regard to D3 and D6. CONCLUSION No difference due to the intraoral environment was revealed. The simulator will contribute to the higher accuracy of intraoral scanners in the future. PMID:29503715

A methodology towards virtualisation-based high performance simulation platform supporting multidisciplinary design of complex products

NASA Astrophysics Data System (ADS)

Ren, Lei; Zhang, Lin; Tao, Fei; (Luke) Zhang, Xiaolong; Luo, Yongliang; Zhang, Yabin

2012-08-01

Multidisciplinary design of complex products leads to an increasing demand for high performance simulation (HPS) platforms. One great challenge is how to achieve high efficient utilisation of large-scale simulation resources in distributed and heterogeneous environments. This article reports a virtualisation-based methodology to realise a HPS platform. This research is driven by the issues concerning large-scale simulation resources deployment and complex simulation environment construction, efficient and transparent utilisation of fine-grained simulation resources and high reliable simulation with fault tolerance. A framework of virtualisation-based simulation platform (VSIM) is first proposed. Then the article investigates and discusses key approaches in VSIM, including simulation resources modelling, a method to automatically deploying simulation resources for dynamic construction of system environment, and a live migration mechanism in case of faults in run-time simulation. Furthermore, the proposed methodology is applied to a multidisciplinary design system for aircraft virtual prototyping and some experiments are conducted. The experimental results show that the proposed methodology can (1) significantly improve the utilisation of fine-grained simulation resources, (2) result in a great reduction in deployment time and an increased flexibility for simulation environment construction and (3)achieve fault tolerant simulation.

A Collaborative Extensible User Environment for Simulation and Knowledge Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freedman, Vicky L.; Lansing, Carina S.; Porter, Ellen A.

2015-06-01

In scientific simulation, scientists use measured data to create numerical models, execute simulations and analyze results from advanced simulators executing on high performance computing platforms. This process usually requires a team of scientists collaborating on data collection, model creation and analysis, and on authorship of publications and data. This paper shows that scientific teams can benefit from a user environment called Akuna that permits subsurface scientists in disparate locations to collaborate on numerical modeling and analysis projects. The Akuna user environment is built on the Velo framework that provides both a rich client environment for conducting and analyzing simulations andmore » a Web environment for data sharing and annotation. Akuna is an extensible toolset that integrates with Velo, and is designed to support any type of simulator. This is achieved through data-driven user interface generation, use of a customizable knowledge management platform, and an extensible framework for simulation execution, monitoring and analysis. This paper describes how the customized Velo content management system and the Akuna toolset are used to integrate and enhance an effective collaborative research and application environment. The extensible architecture of Akuna is also described and demonstrates its usage for creation and execution of a 3D subsurface simulation.« less

PELS (Planetary Environmental Liquid Simulator): a new type of simulation facility to study extraterrestrial aqueous environments.

PubMed

Martin, Derek; Cockell, Charles S

2015-02-01

Investigations of other planetary bodies, including Mars and icy moons such as Enceladus and Europa, show that they may have hosted aqueous environments in the past and may do so even today. Therefore, a major challenge in astrobiology is to build facilities that will allow us to study the geochemistry and habitability of these extraterrestrial environments. Here, we describe a simulation facility (PELS: Planetary Environmental Liquid Simulator) with the capability for liquid input and output that allows for the study of such environments. The facility, containing six separate sample vessels, allows for statistical replication of samples. Control of pressure, gas composition, UV irradiation conditions, and temperature allows for the precise replication of aqueous conditions, including subzero brines under martian atmospheric conditions. A sample acquisition system allows for the collection of both liquid and solid samples from within the chamber without breaking the atmospheric conditions, enabling detailed studies of the geochemical evolution and habitability of past and present extraterrestrial environments. The facility we describe represents a new frontier in planetary simulation-continuous flow-through simulation of extraterrestrial aqueous environments.

Methodology for testing infrared focal plane arrays in simulated nuclear radiation environments

NASA Astrophysics Data System (ADS)

Divita, E. L.; Mills, R. E.; Koch, T. L.; Gordon, M. J.; Wilcox, R. A.; Williams, R. E.

1992-07-01

This paper summarizes test methodology for focal plane array (FPA) testing that can be used for benign (clear) and radiation environments, and describes the use of custom dewars and integrated test equipment in an example environment. The test methodology, consistent with American Society for Testing Materials (ASTM) standards, is presented for the total accumulated gamma dose, transient dose rate, gamma flux, and neutron fluence environments. The merits and limitations of using Cobalt 60 for gamma environment simulations and of using various fast-neutron reactors and neutron sources for neutron simulations are presented. Test result examples are presented to demonstrate test data acquisition and FPA parameter performance under different measurement conditions and environmental simulations.

Theory of quantized systems: formal basis for DEVS/HLA distributed simulation environment

NASA Astrophysics Data System (ADS)

Zeigler, Bernard P.; Lee, J. S.

1998-08-01

In the context of a DARPA ASTT project, we are developing an HLA-compliant distributed simulation environment based on the DEVS formalism. This environment will provide a user- friendly, high-level tool-set for developing interoperable discrete and continuous simulation models. One application is the study of contract-based predictive filtering. This paper presents a new approach to predictive filtering based on a process called 'quantization' to reduce state update transmission. Quantization, which generates state updates only at quantum level crossings, abstracts a sender model into a DEVS representation. This affords an alternative, efficient approach to embedding continuous models within distributed discrete event simulations. Applications of quantization to message traffic reduction are discussed. The theory has been validated by DEVSJAVA simulations of test cases. It will be subject to further test in actual distributed simulations using the DEVS/HLA modeling and simulation environment.

Investigation of Propagation in Foliage Using Simulation Techniques

DTIC Science & Technology

2011-12-01

simulation models provide a rough approximation to radiowave propagation in an actual rainforest environment. Based on the simulated results, the...simulation models provide a rough approximation to radiowave propagation in an actual rainforest environment. Based on the simulated results, the path... Rainforest ...............................2 2. Electrical Properties of a Forest .........................................................3 B. OBJECTIVES OF

Three-dimensional simulation and auto-stereoscopic 3D display of the battlefield environment based on the particle system algorithm

NASA Astrophysics Data System (ADS)

Ning, Jiwei; Sang, Xinzhu; Xing, Shujun; Cui, Huilong; Yan, Binbin; Yu, Chongxiu; Dou, Wenhua; Xiao, Liquan

2016-10-01

The army's combat training is very important now, and the simulation of the real battlefield environment is of great significance. Two-dimensional information has been unable to meet the demand at present. With the development of virtual reality technology, three-dimensional (3D) simulation of the battlefield environment is possible. In the simulation of 3D battlefield environment, in addition to the terrain, combat personnel and the combat tool ,the simulation of explosions, fire, smoke and other effects is also very important, since these effects can enhance senses of realism and immersion of the 3D scene. However, these special effects are irregular objects, which make it difficult to simulate with the general geometry. Therefore, the simulation of irregular objects is always a hot and difficult research topic in computer graphics. Here, the particle system algorithm is used for simulating irregular objects. We design the simulation of the explosion, fire, smoke based on the particle system and applied it to the battlefield 3D scene. Besides, the battlefield 3D scene simulation with the glasses-free 3D display is carried out with an algorithm based on GPU 4K super-multiview 3D video real-time transformation method. At the same time, with the human-computer interaction function, we ultimately realized glasses-free 3D display of the simulated more realistic and immersed 3D battlefield environment.

The Lewis Research Center geomagnetic substorm simulation facility

NASA Technical Reports Server (NTRS)

Berkopec, F. D.; Stevens, N. J.; Sturman, J. C.

1977-01-01

A simulation facility was established to determine the response of typical spacecraft materials to the geomagnetic substorm environment and to evaluate instrumentation that will be used to monitor spacecraft system response to this environment. Space environment conditions simulated include the thermal-vacuum conditions of space, solar simulation, geomagnetic substorm electron fluxes and energies, and the low energy plasma environment. Measurements for spacecraft material tests include sample currents, sample surface potentials, and the cumulative number of discharges. Discharge transients are measured by means of current probes and oscilloscopes and are verified by a photomultiplier. Details of this facility and typical operating procedures are presented.

Evaluation of the effects of solar radiation on glass. [space environment simulation

NASA Technical Reports Server (NTRS)

Firestone, R. F.; Harada, Y.

1979-01-01

The degradation of glass used on space structures due to electromagnetic and particulate radiation in a space environment was evaluated. The space environment was defined and a simulated space exposure apparatus was constructed. Four optical materials were exposed to simulated solar and particulate radiation in a space environment. Sapphire and fused silica experienced little change in transmittance, while optical crown glass and ultra low expansion glass darkened appreciably. Specimen selection and preparation, exposure conditions, and the effect of simulated exposure are discussed. A selective bibliography of the effect of radiation on glass is included.

Virtual operating room for team training in surgery.

PubMed

Abelson, Jonathan S; Silverman, Elliott; Banfelder, Jason; Naides, Alexandra; Costa, Ricardo; Dakin, Gregory

2015-09-01

We proposed to develop a novel virtual reality (VR) team training system. The objective of this study was to determine the feasibility of creating a VR operating room to simulate a surgical crisis scenario and evaluate the simulator for construct and face validity. We modified ICE STORM (Integrated Clinical Environment; Systems, Training, Operations, Research, Methods), a VR-based system capable of modeling a variety of health care personnel and environments. ICE STORM was used to simulate a standardized surgical crisis scenario, whereby participants needed to correct 4 elements responsible for loss of laparoscopic visualization. The construct and face validity of the environment were measured. Thirty-three participants completed the VR simulation. Attendings completed the simulation in less time than trainees (271 vs 201 seconds, P = .032). Participants felt the training environment was realistic and had a favorable impression of the simulation. All participants felt the workload of the simulation was low. Creation of a VR-based operating room for team training in surgery is feasible and can afford a realistic team training environment. Copyright © 2015 Elsevier Inc. All rights reserved.

An object oriented Python interface for atomistic simulations

NASA Astrophysics Data System (ADS)

Hynninen, T.; Himanen, L.; Parkkinen, V.; Musso, T.; Corander, J.; Foster, A. S.

2016-01-01

Programmable simulation environments allow one to monitor and control calculations efficiently and automatically before, during, and after runtime. Environments directly accessible in a programming environment can be interfaced with powerful external analysis tools and extensions to enhance the functionality of the core program, and by incorporating a flexible object based structure, the environments make building and analysing computational setups intuitive. In this work, we present a classical atomistic force field with an interface written in Python language. The program is an extension for an existing object based atomistic simulation environment.

Psychological and physiological human responses to simulated and real environments: A comparison between Photographs, 360° Panoramas, and Virtual Reality.

PubMed

Higuera-Trujillo, Juan Luis; López-Tarruella Maldonado, Juan; Llinares Millán, Carmen

2017-11-01

Psychological research into human factors frequently uses simulations to study the relationship between human behaviour and the environment. Their validity depends on their similarity with the physical environments. This paper aims to validate three environmental-simulation display formats: photographs, 360° panoramas, and virtual reality. To do this we compared the psychological and physiological responses evoked by simulated environments set-ups to those from a physical environment setup; we also assessed the users' sense of presence. Analysis show that 360° panoramas offer the closest to reality results according to the participants' psychological responses, and virtual reality according to the physiological responses. Correlations between the feeling of presence and physiological and other psychological responses were also observed. These results may be of interest to researchers using environmental-simulation technologies currently available in order to replicate the experience of physical environments. Copyright © 2017 Elsevier Ltd. All rights reserved.

Using IMPRINT to Guide Experimental Design with Simulated Task Environments

DTIC Science & Technology

2015-06-18

USING IMPRINT TO GUIDE EXPERIMENTAL DESIGN OF SIMULATED TASK ENVIRONMENTS THESIS Gregory...ENG-MS-15-J-052 USING IMPRINT TO GUIDE EXPERIMENTAL DESIGN WITH SIMULATED TASK ENVIRONMENTS THESIS Presented to the Faculty Department...Civilian, USAF June 2015 DISTRIBUTION STATEMENT A. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENG-MS-15-J-052 USING IMPRINT

NASA research on refractory compounds.

NASA Technical Reports Server (NTRS)

Gangler, J. J.

1971-01-01

The behavior and properties of the refractory carbides, nitrides, and borides are being investigated by NASA as part of its research aimed at developing superior heat resistant materials for aerospace applications. Studies of the zirconium-carbon-oxygen system show that zirconium oxycarbides of different compositions and lattice parameters can be formed between 1500 C and 1900 C and are stable below 1500 C. More applied studies show that hot working generally improves the microstructure and therefore the strength of TiC and NbC. Sintering studies on UN indicate that very high densities can be achieved. Hot pressing of cermets of HfN and HfC produces good mechanical properties for high temperature bearing applications. Attempts to improve the impact resistance of boride composites by the addition of a nickel or carbon yarn were not overly successful.

"A tempest in a cocktail glass": mothers, alcohol, and television, 1977-1996.

PubMed

Golden, J

2000-06-01

This article examines the portrayal of pregnancy and alcohol in thirty-six national network evening news broadcasts (ABC, CBS, NBC). Early coverage focused on white, middle-class women, as scientific authorities and government officials warned against drinking during pregnancy. After 1987, however, women who drank during pregnancy were depicted as members of minority groups and as a danger to society. The thematic transition began before warning labels appeared on alcoholic beverages and gained strength from official government efforts to prevent fetal alcohol syndrome. The greatest impetus for the revised discourse, however, was the eruption of a "moral panic" over crack cocaine use. By linking fetal harm to substance abuse, the panic suggested it was in the public's interest to control the behavior of pregnant women.

Structural, elastic and electronic properties of transition metal carbides ZnC, NbC and their ternary alloys ZnxNb1-xC

NASA Astrophysics Data System (ADS)

Zidi, Y.; Méçabih, S.; Abbar, B.; Amari, S.

2018-02-01

We have investigated the structural, electronic and elastic properties of transition-metal carbides ZnxNb1-xC alloys in the range of 0 ≤ x ≤ 1 using the density functional theory (DFT). The full potential linearized augmented plane wave (FP-LAPW) method within a framework of the generalized gradient approximation (GGA) and GGA + U (where U is the Hubbard correlation terms) approach is used to perform the calculations presented here. The lattice parameters, the bulk modulus, its pressure derivative and the elastic constants were determined. We have obtained Young's modulus, shear modulus, Poisson's ratio, anisotropy factor by the aid of the calculated elastic constants. We discuss the total and partial densities of states and charge densities.

Health issue advertising.

PubMed

Coleman, L J; Haran, E M

1990-01-01

"Americans say that the battle against drugs is the chief issue facing the nation" (McQueen and Shribman, 1989). The Wall Street Journal/NBC poll conducted by Peter Hart and Robert Teeter shows a public willingness to experiment with a wide variety of anti-drug efforts. "No single issue has so riveted the nation's attention since the 1982 recession," Messers. Hart and Teeter say in their analysis of the poll. They add that respondents seem willing to try almost anything to solve the drug problem (ibid). How can and does marketing affect this process? This paper will examine some of the methods and effectiveness of advertising in regard to this very timely health issue and societal challenge. For the purposes of this paper, drug discussions refer to alcohol as well. Social marketing in general will be addressed.

REVIEWS OF TOPICAL PROBLEMS: Order-disorder transformations and phase equilibria in strongly nonstoichiometric compounds

NASA Astrophysics Data System (ADS)

Gusev, Aleksandr I.

2000-01-01

Data on order-disorder phase transformations in strongly nonstoichiometric carbides and nitrides MXy (X=C, N) of Group IV and V transition metals at temperatures below 1300-1400 K are reviewed. The order-parameter functional method as applied to atomic and vacancy ordering in strongly nonstoichiometric MXy compounds and to phase equilibrium calculations for M-X systems is discussed. Phase diagram calculations for the Ti-C, Zr-C, Hf-C, V-C, Nb-C, Ta-C, Ti-N, and Ti-B-C systems (with the inclusion of the ordering of nonstoichiometric carbides and nitrides) and those for pseudobinary carbide M(1)C-M(2)C systems are presented. Heat capacity, electrical resistivity and magnetic susceptibility changes at reversible order-disorder phase transformations in nonstoichiometric carbides are considered.

A Simulated Learning Environment for Teaching Medicine Dispensing Skills

PubMed Central

Styles, Kim; Sewell, Keith; Trinder, Peta; Marriott, Jennifer; Maher, Sheryl; Naidu, Som

2016-01-01

Objective. To develop an authentic simulation of the professional practice dispensary context for students to develop their dispensing skills in a risk-free environment. Design. A development team used an Agile software development method to create MyDispense, a web-based simulation. Modeled on virtual learning environments elements, the software employed widely available standards-based technologies to create a virtual community pharmacy environment. Assessment. First-year pharmacy students who used the software in their tutorials, were, at the end of the second semester, surveyed on their prior dispensing experience and their perceptions of MyDispense as a tool to learn dispensing skills. Conclusion. The dispensary simulation is an effective tool for helping students develop dispensing competency and knowledge in a safe environment. PMID:26941437

An examination of speech reception thresholds measured in a simulated reverberant cafeteria environment.

PubMed

Best, Virginia; Keidser, Gitte; Buchholz, Jörg M; Freeston, Katrina

2015-01-01

There is increasing demand in the hearing research community for the creation of laboratory environments that better simulate challenging real-world listening environments. The hope is that the use of such environments for testing will lead to more meaningful assessments of listening ability, and better predictions about the performance of hearing devices. Here we present one approach for simulating a complex acoustic environment in the laboratory, and investigate the effect of transplanting a speech test into such an environment. Speech reception thresholds were measured in a simulated reverberant cafeteria, and in a more typical anechoic laboratory environment containing background speech babble. The participants were 46 listeners varying in age and hearing levels, including 25 hearing-aid wearers who were tested with and without their hearing aids. Reliable SRTs were obtained in the complex environment, but led to different estimates of performance and hearing-aid benefit from those measured in the standard environment. The findings provide a starting point for future efforts to increase the real-world relevance of laboratory-based speech tests.

An examination of speech reception thresholds measured in a simulated reverberant cafeteria environment

PubMed Central

Best, Virginia; Keidser, Gitte; Buchholz, J(x004E7)rg M.; Freeston, Katrina

2016-01-01

Objective There is increasing demand in the hearing research community for the creation of laboratory environments that better simulate challenging real-world listening environments. The hope is that the use of such environments for testing will lead to more meaningful assessments of listening ability, and better predictions about the performance of hearing devices. Here we present one approach for simulating a complex acoustic environment in the laboratory, and investigate the effect of transplanting a speech test into such an environment. Design Speech reception thresholds were measured in a simulated reverberant cafeteria, and in a more typical anechoic laboratory environment containing background speech babble. Study Sample The participants were 46 listeners varying in age and hearing levels, including 25 hearing-aid wearers who were tested with and without their hearing aids. Results Reliable SRTs were obtained in the complex environment, but led to different estimates of performance and hearing aid benefit from those measured in the standard environment. Conclusions The findings provide a starting point for future efforts to increase the real-world relevance of laboratory-based speech tests. PMID:25853616

Using Social Simulations to Assess and Train Potential Leaders to Make Effective Decisions in Turbulent Environments

ERIC Educational Resources Information Center

Hunsaker, L. Phillip

2007-01-01

Purpose: The purpose of this paper is to describe two social simulations created to assess leadership potential and train leaders to make effective decisions in turbulent environments. One is set in the novel environment of a lunar moon colony and the other is a military combat command. The research generated from these simulations for assessing…

Multidisciplinary research leading to utilization of extraterrestrial resources

NASA Technical Reports Server (NTRS)

1972-01-01

Progress of the research accomplished during fiscal year 1972 is reported. The summaries presented include: (1) background analysis and coordination, (2) surface properties of rock in simulated lunar environment, (3) rock failure processes, strength and elastic properties in simulated lunar environment, (4) thermal fragmentation, and thermophysical and optical properties in simulated lunar environment, and (5) use of explosives on the moon.

Design Patterns for Learning and Assessment: Facilitating the Introduction of a Complex Simulation-Based Learning Environment into a Community of Instructors

ERIC Educational Resources Information Center

Frezzo, Dennis C.; Behrens, John T.; Mislevy, Robert J.

2010-01-01

Simulation environments make it possible for science and engineering students to learn to interact with complex systems. Putting these capabilities to effective use for learning, and assessing learning, requires more than a simulation environment alone. It requires a conceptual framework for the knowledge, skills, and ways of thinking that are…

Real-Time and High-Fidelity Simulation Environment for Autonomous Ground Vehicle Dynamics

NASA Technical Reports Server (NTRS)

Cameron, Jonathan; Myint, Steven; Kuo, Calvin; Jain, Abhi; Grip, Havard; Jayakumar, Paramsothy; Overholt, Jim

2013-01-01

This paper reports on a collaborative project between U.S. Army TARDEC and Jet Propulsion Laboratory (JPL) to develop a unmanned ground vehicle (UGV) simulation model using the ROAMS vehicle modeling framework. Besides modeling the physical suspension of the vehicle, the sensing and navigation of the HMMWV vehicle are simulated. Using models of urban and off-road environments, the HMMWV simulation was tested in several ways, including navigation in an urban environment with obstacle avoidance and the performance of a lane change maneuver.

Virtual environments simulation in research reactor

NASA Astrophysics Data System (ADS)

Muhamad, Shalina Bt. Sheik; Bahrin, Muhammad Hannan Bin

2017-01-01

Virtual reality based simulations are interactive and engaging. It has the useful potential in improving safety training. Virtual reality technology can be used to train workers who are unfamiliar with the physical layout of an area. In this study, a simulation program based on the virtual environment at research reactor was developed. The platform used for virtual simulation is 3DVia software for which it's rendering capabilities, physics for movement and collision and interactive navigation features have been taken advantage of. A real research reactor was virtually modelled and simulated with the model of avatars adopted to simulate walking. Collision detection algorithms were developed for various parts of the 3D building and avatars to restrain the avatars to certain regions of the virtual environment. A user can control the avatar to move around inside the virtual environment. Thus, this work can assist in the training of personnel, as in evaluating the radiological safety of the research reactor facility.

A new airborne laser rangefinder dynamic target simulator for non-stationary environment

NASA Astrophysics Data System (ADS)

Ma, Pengge; Pang, Dongdong; Yi, Yang

2017-11-01

For the non-stationary environment simulation in laser range finder product testing, a new dynamic target simulation system is studied. First of all, the three-pulsed laser ranging principle, laser target signal composition and mathematical representation are introduced. Then, the actual nonstationary working environment of laser range finder is analyzed, and points out that the real sunshine background light clutter and target shielding effect in laser echo become the main influencing factors. After that, the dynamic laser target signal simulation method is given. Eventlly, the implementation of automatic test system based on arbitrary waveform generator is described. Practical application shows that the new echo signal automatic test system can simulate the real laser ranging environment of laser range finder, and is suitable for performance test of products.

LEGEND, a LEO-to-GEO Environment Debris Model

NASA Technical Reports Server (NTRS)

Liou, Jer Chyi; Hall, Doyle T.

2013-01-01

LEGEND (LEO-to-GEO Environment Debris model) is a three-dimensional orbital debris evolutionary model that is capable of simulating the historical and future debris populations in the near-Earth environment. The historical component in LEGEND adopts a deterministic approach to mimic the known historical populations. Launched rocket bodies, spacecraft, and mission-related debris (rings, bolts, etc.) are added to the simulated environment. Known historical breakup events are reproduced, and fragments down to 1 mm in size are created. The LEGEND future projection component adopts a Monte Carlo approach and uses an innovative pair-wise collision probability evaluation algorithm to simulate the future breakups and the growth of the debris populations. This algorithm is based on a new "random sampling in time" approach that preserves characteristics of the traditional approach and captures the rapidly changing nature of the orbital debris environment. LEGEND is a Fortran 90-based numerical simulation program. It operates in a UNIX/Linux environment.

Analysis of the effects of simulated synergistic LEO environment on solar panels

NASA Astrophysics Data System (ADS)

Allegri, G.; Corradi, S.; Marchetti, M.; Scaglione, S.

2007-02-01

The effects due to the LEO environment exposure of a solar array primary structure are here presented and discussed in detail. The synergistic damaging components featuring LEO environment are high vacuum, thermal cycling, neutral gas, ultraviolet (UV) radiation and cold plasma. The synergistic effects due to these environmental elements are simulated by "on ground" tests, performed in the Space Environment Simulator (SAS) at the University of Rome "La Sapienza"; numerical simulations are performed by the Space Environment Information System (SPENVIS), developed by the European Space Agency (ESA). A "safe life" design for a solar array primary structure is developed, taking into consideration the combined damaging action of the LEO environment components; therefore results from both numerical and experimental simulations are coupled within the framework of a standard finite element method (FEM) based design. The expected durability of the solar array primary structure, made of laminated sandwich composite, is evaluated assuming that the loads exerted on the structure itself are essentially dependent on thermo-elastic stresses. The optical degradation of surface materials and the stiffness and strength degradation of structural elements are taken into account to assess the global structural durability of the solar array under characteristic operative conditions in LEO environment.

[Cordyceps sinensis enhances lymphocyte proliferation and CD markers expression in simulated microgravity environment].

PubMed

Hao, Tong; Li, Jun-Jie; Du, Zhi-Yan; Duan, Cui-Mi; Wang, Yan-Meng; Wang, Chang-Yong; Song, Jing-Ping; Wang, Lin-Jie; Li, Ying-Hui; Wang, Yan

2012-10-01

This study was aimed to explore the effect of cordyceps sinensis enhancing lymphocyte proliferation and surface CD marker expression in simulated microgravity environment. The splenic lymphocytes were separated from mice and cultured in the rotary cell culture system simulated microgravity environment. The cells were treated with different concentration of cordyceps sinensis solution (0, 6.25, 12.5, 25 and 50 µg/ml) for 24, 48 and 72 h respectively, then the cells were harvested, and analyzed for cell proliferation and the expression of cell surface markers (CD4 and CD8). The results showed that under simulated microgravity environment, the lymphocyte proliferation was inhibited. When the concentration of cordyceps sinensis was 25 or 50 µg/ml, the lymphocyte proliferation, CD4 and CD8 expressions all increased, but 50 µg/ml cordyceps sinensis could inhibit the proliferation ability with the time prolonging. It is concluded that the suitable concentration of cordyceps sinensis displayed the ability to enhance the lymphocyte proliferation and CD marker expression in simulated microgravity environment. These results may be valuable for screening drugs which can be potentially against immunosuppression under simulated microgravity.

Compensatory role of the NBCn1 sodium/bicarbonate cotransporter on Ca2+-induced mitochondrial swelling in hypertrophic hearts.

PubMed

Vargas, Lorena A; Velasquez, Fernanda Carrizo; Alvarez, Bernardo V

2017-03-01

NBC Na + /HCO 3 - cotransporter (NBCn1) and NHE1 Na + /H + exchanger have been associated with cardiac disorders and recently located in coronary endothelial cells (CEC) and cardiomyocytes mitochondria, respectively. Mitochondrial NHE1 blockade delays permeability transition pore (MPTP) opening and reduces superoxide levels, two critical events exacerbated in cells of diseased hearts. Conversely, activation of NBCn1 prevented apoptosis in CEC subjected to ischemic stress. We characterized the role of the NHE1 and NBCn1 transporters in heart mitochondria from hypertrophic (SHR) and control (Wistar) rats. Expression of NHE1 was analyzed in left ventricular mitochondrial lysates (LVML), by immunoblots. NHE1 expression increased by ~40% in SHR compared to control (P < 0.05, n = 4). To examine NHE1-mediated Na + /H + exchange activity in cardiac hypertrophy, mitochondria were loaded with BCECF-AM dye and the maximal rate of pHm change measured after the addition of 50 mM NaCl. SHR mitochondria had greater changes in pHm compared to Wistar, 0.10 ± 0.01 vs. 0.06 ± 0.01, respectively (P < 0.05, n = 5). In addition, mitochondrial suspensions from SHR and control myocardium were exposed to 200 μM CaCl 2 to induce MPTP opening (light-scattering decrease, LSD) and swelling. Surprisingly, SHR rats showed smaller LSD and a reduction in mitochondrial swelling, 67 ± 10% (n = 15), compared to control, 100 ± 8% (n = 13). NBC inhibition with S0859 (1 μM) significantly increased swelling in both control 139 ± 10% (n = 8) and SHR 115 ± 10% (n = 4). Finally, NBCn1 Na + /HCO 3 - cotransporter increased by twofold its expression in SHR LVML, compared to normal (P < 0.05, n = 5). We conclude that increased NBCn1 activity may play a compensatory role in hypertrophic hearts, protecting mitochondria from Ca 2+ -induced MPTP opening and swelling.

Functional and molecular characterization of transmembrane intracellular pH regulators in human dental pulp stem cells.

PubMed

Chen, Gunng-Shinng; Lee, Shiao-Pieng; Huang, Shu-Fu; Chao, Shih-Chi; Chang, Chung-Yi; Wu, Gwo-Jang; Li, Chung-Hsing; Loh, Shih-Hurng

2018-06-01

Homeostasis of intracellular pH (pH i ) plays vital roles in many cell functions, such as proliferation, apoptosis, differentiation and metastasis. Thus far, Na + -H + exchanger (NHE), Na + -HCO 3 - co-transporter (NBC), Cl - /HCO 3 - exchanger (AE) and Cl - /OH - exchanger (CHE) have been identified to co-regulate pH i homeostasis. However, functional and biological pH i -regulators in human dental pulp stem cells (hDPSCs) have yet to be identified. Microspectrofluorimetry technique with pH-sensitive fluorescent dye, BCECF, was used to detect pH i changes. NH 4 Cl and Na + -acetate pre-pulse were used to induce intracellular acidosis and alkalosis, respectively. Isoforms of pH i -regulators were detected by Western blot technique. The resting pH i was no significant difference between that in HEPES-buffered (nominal HCO 3 - -free) solution or CO 2 /HCO 3 -buffered system (7.42 and 7.46, respectively). The pH i recovery following the induced-intracellular acidosis was blocked completely by removing [Na + ] o , while only slowed (-63%) by adding HOE694 (a NHE1 specific inhibitor) in HEPES-buffered solution. The pH i recovery was inhibited entirely by removing [Na + ] o , while adding HOE 694 pulse DIDS (an anion-transporter inhibitor) only slowed (-55%) the acid extrusion. Both in HEPES-buffered and CO 2 /HCO 3 -buffered system solution, the pH i recovery after induced-intracellular alkalosis was entirely blocked by removing [Cl - ] o . Western blot analysis showed the isoforms of pH i regulators, including NHE1/2, NBCe1/n1, AE1/2/3/4 and CHE in the hDPSCs. We demonstrate for the first time that resting pH i is significantly higher than 7.2 and meditates functionally by two Na + -dependent acid extruders (NHE and NBC), two Cl - -dependent acid loaders (CHE and AE) and one Na + -independent acid extruder(s) in hDPSCs. These findings provide novel insight for basic and clinical treatment of dentistry. Copyright © 2018 Elsevier Ltd. All rights reserved.

Comparative molecular analyses of select pH- and osmoregulatory genes in three freshwater crayfish Cherax quadricarinatus, C. destructor and C. cainii

PubMed Central

Pavasovic, Ana; Dammannagoda, Lalith K.; Mather, Peter B.; Prentis, Peter J.

2017-01-01

Systemic acid-base balance and osmotic/ionic regulation in decapod crustaceans are in part maintained by a set of transport-related enzymes such as carbonic anhydrase (CA), Na+/K+-ATPase (NKA), H+-ATPase (HAT), Na+/K+/2Cl− cotransporter (NKCC), Na+/Cl−/HCO\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}${}_{3}^{-}$\\end{document}3− cotransporter (NBC), Na+/H+ exchanger (NHE), Arginine kinase (AK), Sarcoplasmic Ca+2-ATPase (SERCA) and Calreticulin (CRT). We carried out a comparative molecular analysis of these genes in three commercially important yet eco-physiologically distinct freshwater crayfish, Cherax quadricarinatus, C. destructor and C. cainii, with the aim to identify mutations in these genes and determine if observed patterns of mutations were consistent with the action of natural selection. We also conducted a tissue-specific expression analysis of these genes across seven different organs, including gills, hepatopancreas, heart, kidney, liver, nerve and testes using NGS transcriptome data. The molecular analysis of the candidate genes revealed a high level of sequence conservation across the three Cherax sp. Hyphy analysis revealed that all candidate genes showed patterns of molecular variation consistent with neutral evolution. The tissue-specific expression analysis showed that 46% of candidate genes were expressed in all tissue types examined, while approximately 10% of candidate genes were only expressed in a single tissue type. The largest number of genes was observed in nerve (84%) and gills (78%) and the lowest in testes (66%). The tissue-specific expression analysis also revealed that most of the master genes regulating pH and osmoregulation (CA, NKA, HAT, NKCC, NBC, NHE) were expressed in all tissue types indicating an important physiological role for these genes outside of osmoregulation in other tissue types. The high level of sequence conservation observed in the candidate genes may be explained by the important role of these genes as well as potentially having a number of other basic physiological functions in different tissue types. PMID:28852583

Nuclear design analysis of square-lattice honeycomb space nuclear rocket engine

NASA Astrophysics Data System (ADS)

Widargo, Reza; Anghaie, Samim

1999-01-01

The square-lattice honeycomb reactor is designed based on a cylindrical core that is determined to have critical diameter and length of 0.50 m and 0.50 c, respectively. A 0.10-cm thick radial graphite reflector, in addition to a 0.20-m thick axial graphite reflector are used to reduce neutron leakage from the reactor. The core is fueled with solid solution of 93% enriched (U, Zr, Nb)C, which is one of several ternary uranium carbides that are considered for this concept. The fuel is to be fabricated as 2 mm grooved (U, Zr, Nb)C wafers. The fuel wafers are used to form square-lattice honeycomb fuel assemblies, 0.10 m in length with 30% cross-sectional flow area. Five fuel assemblies are stacked up axially to form the reactor core. Based on the 30% void fraction, the width of the square flow channel is about 1.3 mm. The hydrogen propellant is passed through these flow channels and removes the heat from the reactor core. To perform nuclear design analysis, a series of neutron transport and diffusion codes are used. The preliminary results are obtained using a simple four-group cross-section model. To optimize the nuclear design, the fuel densities are varied for each assembly. Tantalum, hafnium and tungsten are considered and used as a replacement for niobium in fuel material to provide water submersion sub-criticality for the reactor. Axial and radial neutron flux and power density distributions are calculated for the core. Results of the neutronic analysis indicate that the core has a relatively fast spectrum. From the results of the thermal hydraulic analyses, eight axial temperature zones are chosen for the calculation of group average cross-sections. An iterative process is conducted to couple the neutronic calculations with the thermal hydraulics calculations. Results of the nuclear design analysis indicate that a compact core can be designed based on ternary uranium carbide square-lattice honeycomb fuel. This design provides a relatively high thrust to weight ratio.

Simultaneous Quantification of Forskolin and Iso-Forskolin in Coleus forskohlii (Wild.) Briq. and Identification of Elite Chemotype, Collected from Eastern Ghats (India).

PubMed

Shukla, Pushpendra Kumar; Misra, Ankita; Kumar, Manish; Jaichand; Singh, Kuldeep; Akhtar, Juber; Srivastava, Sharad; Agrawal, Pawan K; Singh Rawat, Ajay K

2018-01-01

Coleus forskohlii is a well-known industrially important medicinal plant, for its high forskolin content. A simple, selective, and sensitive high-performance thin layer chromatography (HPTLC) method was developed and validated for simultaneous quantification of forskolin and iso-forskolin in C. forskohlii germplasm collected from the Eastern Ghats, India. Chromatographic separation of the targeted marker(s) was obtained on precoated silica plates using toluene: ethyl acetate: methanol (90:30:0.5, v/v/v) as the mobile phase. Densitometric quantification of forskolin and iso-forskolin was carried out at 545 nm. Forskolin and iso-forskolin were identified by comparing the ultraviolet spectra of standard and sample track at R f of 0.64 ± 0.02 and 0.36 ± 0.01, after derivatization with anisaldehyde sulfuric acid reagent. The linearity of both the analytes was obtained in the range of 300-1200 ng/spot with the regression coefficient ( R 2 ) of 0.991 and 0.986. Recovery of analyte (s) at three levels, namely, 100, 150, and 200 ng/spot was found to be 100.46% ± 0.29%, 99.64% ± 0.33%, 100.02% ± 0.76% and 99.76% ± 0.62%, 99.56% ± 0.35%, 100.02% ± 0.22%, respectively, for forskolin and iso-forskolin. The content of forskolin and iso-forskolin varies from 0.046% to 0.187% and 0.002% to 0.077%, respectively (dry weight basis), the maximum content of both the markers was found in NBC-31, from Thakurwada, Maharashtra. The developed HPTLC method was linear, accurate, and reliable as per the International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use guidelines. The study aids in the identification of elite chemotype for commercial prospection of industrially viable medicinal crop. 12 Samples are collected from different locations of the eastern ghat regionsQuantification of two major marker forskolin and iso forskolinThe maximum content of both the markers was found in NBC -31, from Thakurwada, MaharashtraIdentification of elite chemotype of collected samples may be useful for commercial prospection in industries.

Reliable Multi-Label Learning via Conformal Predictor and Random Forest for Syndrome Differentiation of Chronic Fatigue in Traditional Chinese Medicine

PubMed Central

Wang, Huazhen; Liu, Xin; Lv, Bing; Yang, Fan; Hong, Yanzhu

2014-01-01

Objective Chronic Fatigue (CF) still remains unclear about its etiology, pathophysiology, nomenclature and diagnostic criteria in the medical community. Traditional Chinese medicine (TCM) adopts a unique diagnostic method, namely ‘bian zheng lun zhi’ or syndrome differentiation, to diagnose the CF with a set of syndrome factors, which can be regarded as the Multi-Label Learning (MLL) problem in the machine learning literature. To obtain an effective and reliable diagnostic tool, we use Conformal Predictor (CP), Random Forest (RF) and Problem Transformation method (PT) for the syndrome differentiation of CF. Methods and Materials In this work, using PT method, CP-RF is extended to handle MLL problem. CP-RF applies RF to measure the confidence level (p-value) of each label being the true label, and then selects multiple labels whose p-values are larger than the pre-defined significance level as the region prediction. In this paper, we compare the proposed CP-RF with typical CP-NBC(Naïve Bayes Classifier), CP-KNN(K-Nearest Neighbors) and ML-KNN on CF dataset, which consists of 736 cases. Specifically, 95 symptoms are used to identify CF, and four syndrome factors are employed in the syndrome differentiation, including ‘spleen deficiency’, ‘heart deficiency’, ‘liver stagnation’ and ‘qi deficiency’. The Results CP-RF demonstrates an outstanding performance beyond CP-NBC, CP-KNN and ML-KNN under the general metrics of subset accuracy, hamming loss, one-error, coverage, ranking loss and average precision. Furthermore, the performance of CP-RF remains steady at the large scale of confidence levels from 80% to 100%, which indicates its robustness to the threshold determination. In addition, the confidence evaluation provided by CP is valid and well-calibrated. Conclusion CP-RF not only offers outstanding performance but also provides valid confidence evaluation for the CF syndrome differentiation. It would be well applicable to TCM practitioners and facilitate the utilities of objective, effective and reliable computer-based diagnosis tool. PMID:24918430

3D multiplayer virtual pets game using Google Card Board

NASA Astrophysics Data System (ADS)

Herumurti, Darlis; Riskahadi, Dimas; Kuswardayan, Imam

2017-08-01

Virtual Reality (VR) is a technology which allows user to interact with the virtual environment. This virtual environment is generated and simulated by computer. This technology can make user feel the sensation when they are in the virtual environment. The VR technology provides real virtual environment view for user and it is not viewed from screen. But it needs another additional device to show the view of virtual environment. This device is known as Head Mounted Device (HMD). Oculust Rift and Microsoft Hololens are the most famous HMD devices used in VR. And in 2014, Google Card Board was introduced at Google I/O developers conference. Google Card Board is VR platform which allows user to enjoy the VR with simple and cheap way. In this research, we explore Google Card Board to develop simulation game of raising pet. The Google Card Board is used to create view for the VR environment. The view and control in VR environment is built using Unity game engine. And the simulation process is designed using Finite State Machine (FSM). This FSM can help to design the process clearly. So the simulation process can describe the simulation of raising pet well. Raising pet is fun activity. But sometimes, there are many conditions which cause raising pet become difficult to do, i.e. environment condition, disease, high cost, etc. this research aims to explore and implement Google Card Board in simulation of raising pet.

The impact of reduced gastric acid secretion on dissolution of salts of weak bases in the fasted upper gastrointestinal lumen: Data in biorelevant media and in human aspirates.

PubMed

Litou, Chara; Vertzoni, Maria; Xu, Wei; Kesisoglou, Filippos; Reppas, Christos

2017-06-01

To propose media for simulating the intragastric environment under reduced gastric acid secretion in the fasted state at three levels of simulation of the gastric environment and evaluate their usefulness in evaluating the intragastric dissolution of salts of weak bases. To evaluate the importance of bicarbonate buffer in biorelevant in vitro dissolution testing when using Level II biorelevant media simulating the environment in the fasted upper small intestine, regardless of gastric acid secretions. Media for simulating the hypochlorhydric and achlorhydric conditions in stomach were proposed using phosphates, maleates and bicarbonates buffers. The impact of bicarbonates in Level II biorelevant media simulating the environment in upper small intestine was evaluated so that pH and bulk buffer capacity were maintained. Dissolution data were collected using two model compounds, pioglitazone hydrochloride and semifumarate cocrystal of Compound B, and the mini-paddle dissolution apparatus in biorelevant media and in human aspirates. Simulated gastric fluids proposed in this study were in line with pH, buffer capacity, pepsin content, total bile salt/lecithin content and osmolality of the fasted stomach under partial and under complete inhibition of gastric acid secretion. Fluids simulating the conditions under partial inhibition of acid secretion were useful in simulating concentrations of both model compounds in gastric aspirates. Bicarbonates in Level III biorelevant gastric media and in Level II biorelevant media simulating the composition in the upper intestinal lumen did not improve simulation of concentrations in human aspirates. Level III biorelevant media for simulating the intragastric environment under hypochlorhydric conditions were proposed and their usefulness in the evaluation of concentrations of two model salts of weak bases in gastric aspirates was shown. Level II biorelevant media for simulating the environment in upper intestinal lumen led to underestimation of concentrations in aspirates, even when bicarbonate buffer was used. Copyright © 2017 Elsevier B.V. All rights reserved.

Spatial interpretation of NASA's Marshall Space Flight Center Payload Operations Control Center using virtual reality technology

NASA Technical Reports Server (NTRS)

Lindsey, Patricia F.

1993-01-01

In its search for higher level computer interfaces and more realistic electronic simulations for measurement and spatial analysis in human factors design, NASA at MSFC is evaluating the functionality of virtual reality (VR) technology. Virtual reality simulation generates a three dimensional environment in which the participant appears to be enveloped. It is a type of interactive simulation in which humans are not only involved, but included. Virtual reality technology is still in the experimental phase, but it appears to be the next logical step after computer aided three-dimensional animation in transferring the viewer from a passive to an active role in experiencing and evaluating an environment. There is great potential for using this new technology when designing environments for more successful interaction, both with the environment and with another participant in a remote location. At the University of North Carolina, a VR simulation of a the planned Sitterson Hall, revealed a flaw in the building's design that had not been observed during examination of the more traditional building plan simulation methods on paper and on computer aided design (CAD) work station. The virtual environment enables multiple participants in remote locations to come together and interact with one another and with the environment. Each participant is capable of seeing herself and the other participants and of interacting with them within the simulated environment.

Generation of large scale urban environments to support advanced sensor and seeker simulation

NASA Astrophysics Data System (ADS)

Giuliani, Joseph; Hershey, Daniel; McKeown, David, Jr.; Willis, Carla; Van, Tan

2009-05-01

One of the key aspects for the design of a next generation weapon system is the need to operate in cluttered and complex urban environments. Simulation systems rely on accurate representation of these environments and require automated software tools to construct the underlying 3D geometry and associated spectral and material properties that are then formatted for various objective seeker simulation systems. Under an Air Force Small Business Innovative Research (SBIR) contract, we have developed an automated process to generate 3D urban environments with user defined properties. These environments can be composed from a wide variety of source materials, including vector source data, pre-existing 3D models, and digital elevation models, and rapidly organized into a geo-specific visual simulation database. This intermediate representation can be easily inspected in the visible spectrum for content and organization and interactively queried for accuracy. Once the database contains the required contents, it can then be exported into specific synthetic scene generation runtime formats, preserving the relationship between geometry and material properties. To date an exporter for the Irma simulation system developed and maintained by AFRL/Eglin has been created and a second exporter to Real Time Composite Hardbody and Missile Plume (CHAMP) simulation system for real-time use is currently being developed. This process supports significantly more complex target environments than previous approaches to database generation. In this paper we describe the capabilities for content creation for advanced seeker processing algorithms simulation and sensor stimulation, including the overall database compilation process and sample databases produced and exported for the Irma runtime system. We also discuss the addition of object dynamics and viewer dynamics within the visual simulation into the Irma runtime environment.

Population Simulation, AKA: Grahz, Rahbitz and Fawkzes

NASA Technical Reports Server (NTRS)

Bangert, Tyler R.

2008-01-01

In an effort to give students a more visceral experience of science and instill a deeper working knowledge of concepts, activities that utilize hands-on, laboratory and simulated experiences are recommended because these activities have a greater impact on student learning, especially for Native American students. Because it is not usually feasible to take large and/or multiple classes of high school science students into the field to count numbers of organisms of a particular species, especially over a long period of time and covering a large area of an environment, the population simulation presented in this paper was created to aid students in understanding population dynamics by working with a simulated environment, which can be done in the classroom. Students create an environment and populate the environment with imaginary species. Then, using a sequence of "rules" that allow organisms to eat, reproduce, move and age, students see how the population of a species changes over time. In particular, students practice collecting data, summarizing information, plotting graphs, and interpreting graphs for such information as carrying capacity, predator prey relationships, and how specific species factors impact population and the environment. Students draw conclusions from their results and suggest further research, which may involve changes in simulation parameters, prediction of outcomes, and testing predictions. The population Simulation has demonstrated success in the above student activities using a "board game" version of the population simulation. A computer version of the population simulation needs more testing, but preliminary runs are promising. A second - and more complicated - computer simulation will simulate the same things and will add simulated population genetics.

Aviation Safety Program Atmospheric Environment Safety Technologies (AEST) Project

NASA Technical Reports Server (NTRS)

Colantonio, Ron

2011-01-01

Engine Icing: Characterization and Simulation Capability: Develop knowledge bases, analysis methods, and simulation tools needed to address the problem of engine icing; in particular, ice-crystal icing Airframe Icing Simulation and Engineering Tool Capability: Develop and demonstrate 3-D capability to simulate and model airframe ice accretion and related aerodynamic performance degradation for current and future aircraft configurations in an expanded icing environment that includes freezing drizzle/rain Atmospheric Hazard Sensing and Mitigation Technology Capability: Improve and expand remote sensing and mitigation of hazardous atmospheric environments and phenomena

Simulating Nonmodel-Fitting Responses in a CAT Environment. ACT Research Report Series 98-10.

ERIC Educational Resources Information Center

Yi, Qing; Nering, Michael L.

This study developed a model to simulate nonmodel-fitting responses in a computerized adaptive testing (CAT) environment, and to examine the effectiveness of the model. The underlying idea was to simulate examinees' test behaviors realistically. This study simulated a situation in which examinees are exposed to or are coached on test items before…

78 FR 6269 - Amendment to the International Traffic in Arms Regulations: Revision of U.S. Munitions List...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... remain subject to USML control are modeling or simulation tools that model or simulate the environments... USML revision process, the public is asked to provide specific examples of nuclear-related items whose...) Modeling or simulation tools that model or simulate the environments generated by nuclear detonations or...

An Investigation of the Potential of Interactive Simulations for Developing System Thinking Skills in Elementary School: A Case Study with Fifth-Graders and Sixth-Graders

ERIC Educational Resources Information Center

Evagorou, Maria; Korfiatis, Kostas; Nicolaou, Christiana; Constantinou, Costas

2009-01-01

The purpose of this study was to investigate the impact of a simulation-based learning environment on elementary school students' (11-12 years old) development of system thinking skills. The learning environment included interactive simulations using the Stagecast Creator software to simulate the ecosystem of a marsh. Simulations are an important…

Entity Modeling and Immersive Decision Environments

DTIC Science & Technology

2011-09-01

Simulation Technologies (REST) Lerman, D. J. (2010). Correct Weather Modeling of non-Standard Days (10F- SIW -004). In Proceedings of 2010 Fall Simulation...Interoperability Workshop (Fall SIW ) SISO. Orlando, FL: SISO. Most flight simulators compute and fly in a weather environment that matches a

Construction of dynamic stochastic simulation models using knowledge-based techniques

NASA Technical Reports Server (NTRS)

Williams, M. Douglas; Shiva, Sajjan G.

1990-01-01

Over the past three decades, computer-based simulation models have proven themselves to be cost-effective alternatives to the more structured deterministic methods of systems analysis. During this time, many techniques, tools and languages for constructing computer-based simulation models have been developed. More recently, advances in knowledge-based system technology have led many researchers to note the similarities between knowledge-based programming and simulation technologies and to investigate the potential application of knowledge-based programming techniques to simulation modeling. The integration of conventional simulation techniques with knowledge-based programming techniques is discussed to provide a development environment for constructing knowledge-based simulation models. A comparison of the techniques used in the construction of dynamic stochastic simulation models and those used in the construction of knowledge-based systems provides the requirements for the environment. This leads to the design and implementation of a knowledge-based simulation development environment. These techniques were used in the construction of several knowledge-based simulation models including the Advanced Launch System Model (ALSYM).

Evaluation and development the routing protocol of a fully functional simulation environment for VANETs

NASA Astrophysics Data System (ADS)

Ali, Azhar Tareq; Warip, Mohd Nazri Mohd; Yaakob, Naimah; Abduljabbar, Waleed Khalid; Atta, Abdu Mohammed Ali

2017-11-01

Vehicular Ad-hoc Networks (VANETs) is an area of wireless technologies that is attracting a great deal of interest. There are still several areas of VANETS, such as security and routing protocols, medium access control, that lack large amounts of research. There is also a lack of freely available simulators that can quickly and accurately simulate VANETs. The main goal of this paper is to develop a freely available VANETS simulator and to evaluate popular mobile ad-hoc network routing protocols in several VANETS scenarios. The VANETS simulator consisted of a network simulator, traffic (mobility simulator) and used a client-server application to keep the two simulators in sync. The VANETS simulator also models buildings to create a more realistic wireless network environment. Ad-Hoc Distance Vector routing (AODV), Dynamic Source Routing (DSR) and Dynamic MANET On-demand (DYMO) were initially simulated in a city, country, and highway environment to provide an overall evaluation.

VERSE - Virtual Equivalent Real-time Simulation

NASA Technical Reports Server (NTRS)

Zheng, Yang; Martin, Bryan J.; Villaume, Nathaniel

2005-01-01

Distributed real-time simulations provide important timing validation and hardware in the- loop results for the spacecraft flight software development cycle. Occasionally, the need for higher fidelity modeling and more comprehensive debugging capabilities - combined with a limited amount of computational resources - calls for a non real-time simulation environment that mimics the real-time environment. By creating a non real-time environment that accommodates simulations and flight software designed for a multi-CPU real-time system, we can save development time, cut mission costs, and reduce the likelihood of errors. This paper presents such a solution: Virtual Equivalent Real-time Simulation Environment (VERSE). VERSE turns the real-time operating system RTAI (Real-time Application Interface) into an event driven simulator that runs in virtual real time. Designed to keep the original RTAI architecture as intact as possible, and therefore inheriting RTAI's many capabilities, VERSE was implemented with remarkably little change to the RTAI source code. This small footprint together with use of the same API allows users to easily run the same application in both real-time and virtual time environments. VERSE has been used to build a workstation testbed for NASA's Space Interferometry Mission (SIM PlanetQuest) instrument flight software. With its flexible simulation controls and inexpensive setup and replication costs, VERSE will become an invaluable tool in future mission development.

Virtual Collaborative Simulation Environment for Integrated Product and Process Development

NASA Technical Reports Server (NTRS)

Gulli, Michael A.

1997-01-01

Deneb Robotics is a leader in the development of commercially available, leading edge three- dimensional simulation software tools for virtual prototyping,, simulation-based design, manufacturing process simulation, and factory floor simulation and training applications. Deneb has developed and commercially released a preliminary Virtual Collaborative Engineering (VCE) capability for Integrated Product and Process Development (IPPD). This capability allows distributed, real-time visualization and evaluation of design concepts, manufacturing processes, and total factory and enterprises in one seamless simulation environment.

The Energy-Environment Simulator as a Classroom Aid.

ERIC Educational Resources Information Center

Sell, Nancy J.; Van Koevering, Thomas E.

1981-01-01

Describes the use, availability, and flexibility of the Energy-Environment Simulator, a specially designed analog computer which simulates the real-world energy situation and which is programed with estimated United States and world supplies of energy sources and estimated United States energy demands. (MP)

STS-96 FD Highlights and Crew Activities Report: Flight Day 05

NASA Technical Reports Server (NTRS)

1999-01-01

On this fifth day of the STS-96 Discovery mission, the flight crew, Commander Kent V. Rominger, Pilot Rick D. Husband, and Mission Specialists Ellen Ochoa, Tamara E. Jernigan, Daniel T. Barry, Julie Payette, and Valery Ivanovich Tokarev are seen performing logistics transfer activities within the Discovery/International Space Station orbiting complex. The crew transfers supplies, equipment, and water. Payette and Tokarev perform maintenance activities on the storage batteries in the Zarya module. Barry and Tokarev install acoustic insulation around some of the fans inside Zarya. Jernigan and Husband install shelving in 2 soft stowage racks. Husband and Barry troubleshoot and perform maintenance activities on the Early Communications System. At the end of the workday, Rominger, Jernigan, and Barry discussed the progress of the mission with NBC's "Today," CBS "This Morning," and CNN.

NASA research on refractory compounds.

NASA Technical Reports Server (NTRS)

Gangler, J. J.

1971-01-01

The behavior and properties of the refractory carbides, nitrides, and borides are being investigated by NASA as part of its research aimed at developing superior heat resistant materials for aerospace applications. Fundamental studies on the electronic and defect structures of the carbides indicate that there is promise for improving the strength and ductility of these materials. Studies of the zirconium-carbon-oxygen system show that zirconium oxycarbides of different compositions and lattice parameters can be formed between 1500 and 1900 C and are stable below 1500 C. More applied studies show that hot working generally improves the microstructure and therefore the strength of TiC and NbC. Sintering studies on UN indicate that very high densities can be achieved. Hot pressing of cermets of HfN and HfC produces good mechanical properties for high temperature bearing applications.

Technical evaluation of the susceptibility of safety-related systems to flooding caused by the failure of non-Category I systems for Turkey Point Nuclear Power Plant, Units 3 and 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, E.K.

1979-08-01

Three separate reviews of the Turkey Point Units 3 and 4 were conducted by the FPLCO between 1972 and 1975. Initially, at the request of NBC in 1972, the FPLCO reviewed several water systems as sources of flooding. Subsequently, as a result of an abnormal occurrence, the drainage system was reviewed. Finally, the facilities were again reviewed at NRC's request and both the potential sources of flooding and safety-related equipment which could be damaged by flooding were identified. The sources of flooding and the appropriate safety equipment are discussed. An evaluation is presented of measures that were taken by FPLCOmore » to minimize the danger of flooding and to protect safety-related equipment.« less

The effect of fidelity: how expert behavior changes in a virtual reality environment.

PubMed

Ioannou, Ioanna; Avery, Alex; Zhou, Yun; Szudek, Jacek; Kennedy, Gregor; O'Leary, Stephen

2014-09-01

We compare the behavior of expert surgeons operating on the "gold standard" of simulation-the cadaveric temporal bone-against a high-fidelity virtual reality (VR) simulation. We aim to determine whether expert behavior changes within the virtual environment and to understand how the fidelity of simulation affects users' behavior. Five expert otologists performed cortical mastoidectomy and cochleostomy on a human cadaveric temporal bone and a VR temporal bone simulator. Hand movement and video recordings were used to derive a range of measures, to facilitate an analysis of surgical technique, and to compare expert behavior between the cadaveric and simulator environments. Drilling time was similar across the two environments. Some measures such as total time and burr change count differed predictably due to the ease of switching burrs within the simulator. Surgical strokes were generally longer in distance and duration in VR, but these measures changed proportionally to cadaveric measures across the stages of the procedure. Stroke shape metrics differed, which was attributed to the modeling of burr behavior within the simulator. This will be corrected in future versions. Slight differences in drill interaction between a virtual environment and the real world can have measurable effects on surgical technique, particularly in terms of stroke length, duration, and curvature. It is important to understand these effects when designing and implementing surgical training programs based on VR simulation--and when improving the fidelity of VR simulators to facilitate use of a similar technique in both real and simulated situations. © 2014 The American Laryngological, Rhinological and Otological Society, Inc.

Systematic analysis of signaling pathways using an integrative environment.

PubMed

Visvanathan, Mahesh; Breit, Marc; Pfeifer, Bernhard; Baumgartner, Christian; Modre-Osprian, Robert; Tilg, Bernhard

2007-01-01

Understanding the biological processes of signaling pathways as a whole system requires an integrative software environment that has comprehensive capabilities. The environment should include tools for pathway design, visualization, simulation and a knowledge base concerning signaling pathways as one. In this paper we introduce a new integrative environment for the systematic analysis of signaling pathways. This system includes environments for pathway design, visualization, simulation and a knowledge base that combines biological and modeling information concerning signaling pathways that provides the basic understanding of the biological system, its structure and functioning. The system is designed with a client-server architecture. It contains a pathway designing environment and a simulation environment as upper layers with a relational knowledge base as the underlying layer. The TNFa-mediated NF-kB signal trans-duction pathway model was designed and tested using our integrative framework. It was also useful to define the structure of the knowledge base. Sensitivity analysis of this specific pathway was performed providing simulation data. Then the model was extended showing promising initial results. The proposed system offers a holistic view of pathways containing biological and modeling data. It will help us to perform biological interpretation of the simulation results and thus contribute to a better understanding of the biological system for drug identification.

Linear Optics Simulation of Quantum Non-Markovian Dynamics

PubMed Central

Chiuri, Andrea; Greganti, Chiara; Mazzola, Laura; Paternostro, Mauro; Mataloni, Paolo

2012-01-01

The simulation of open quantum dynamics has recently allowed the direct investigation of the features of system-environment interaction and of their consequences on the evolution of a quantum system. Such interaction threatens the quantum properties of the system, spoiling them and causing the phenomenon of decoherence. Sometimes however a coherent exchange of information takes place between system and environment, memory effects arise and the dynamics of the system becomes non-Markovian. Here we report the experimental realisation of a non-Markovian process where system and environment are coupled through a simulated transverse Ising model. By engineering the evolution in a photonic quantum simulator, we demonstrate the role played by system-environment correlations in the emergence of memory effects. PMID:23236588

Physics-based approach to haptic display

NASA Technical Reports Server (NTRS)

Brown, J. Michael; Colgate, J. Edward

1994-01-01

This paper addresses the implementation of complex multiple degree of freedom virtual environments for haptic display. We suggest that a physics based approach to rigid body simulation is appropriate for hand tool simulation, but that currently available simulation techniques are not sufficient to guarantee successful implementation. We discuss the desirable features of a virtual environment simulation, specifically highlighting the importance of stability guarantees.

Microbiological assay of the Marshall Space Flight Center neutral buoyancy simulator

NASA Technical Reports Server (NTRS)

Beyerle, F. J.

1973-01-01

A neutral buoyancy simulator tank system is described in terms of microbiological and medical safety for astronauts. The system was designed to simulate a gravity-free state for evaluation of orbital operations in a microorganism-free environment. Methods for the identification and elimination of specific microorganisms are dealt with as measures for a pure system of space environment simulation.

Representing and Enacting Movement: The Body as an Instructional Resource in a Simulator-Based Environment

ERIC Educational Resources Information Center

Sellberg, Charlott

2017-01-01

Simulators are used to practice in a safe setting before training in a safety-critical environment. Since the nature of situations encountered in high-risk domains is complex and dynamic, it is considered important for the simulation to resemble conditions of real world tasks. For this reason, simulation-based training is often discussed in terms…

Simulation in the clinical setting: towards a standard lexicon.

PubMed

Posner, Glenn D; Clark, Marcia L; Grant, Vincent J

2017-01-01

Simulation-based educational activities are happening in the clinical environment but are not all uniform in terms of their objectives, delivery, or outputs. While these activities all provide an opportunity for individual and team training, nuances in the location, timing, notification, and participants impact the potential outcomes of these sessions and objectives achieved. In light of this, there are actually many different types of simulation-based activity that occur in the clinical environment, which has previously all been grouped together as "in situ" simulation. However, what truly defines in situ simulation is how the clinical environment responds in its' natural state, including the personnel, equipment, and systems responsible for care in that environment. Beyond individual and team skill sets, there are threats to patient safety or quality patient care that result from challenges with equipment, processes, or system breakdowns. These have been labeled "latent safety threats." We submit that the opportunity for discovery of latent safety threats is what defines in situ simulation and truly differentiates it from what would be more rightfully called "on-site" simulation. The distinction between the two is highlighted in this article, as well as some of the various sub-types of in situ simulation.

Physical environment virtualization for human activities recognition

NASA Astrophysics Data System (ADS)

Poshtkar, Azin; Elangovan, Vinayak; Shirkhodaie, Amir; Chan, Alex; Hu, Shuowen

2015-05-01

Human activity recognition research relies heavily on extensive datasets to verify and validate performance of activity recognition algorithms. However, obtaining real datasets are expensive and highly time consuming. A physics-based virtual simulation can accelerate the development of context based human activity recognition algorithms and techniques by generating relevant training and testing videos simulating diverse operational scenarios. In this paper, we discuss in detail the requisite capabilities of a virtual environment to aid as a test bed for evaluating and enhancing activity recognition algorithms. To demonstrate the numerous advantages of virtual environment development, a newly developed virtual environment simulation modeling (VESM) environment is presented here to generate calibrated multisource imagery datasets suitable for development and testing of recognition algorithms for context-based human activities. The VESM environment serves as a versatile test bed to generate a vast amount of realistic data for training and testing of sensor processing algorithms. To demonstrate the effectiveness of VESM environment, we present various simulated scenarios and processed results to infer proper semantic annotations from the high fidelity imagery data for human-vehicle activity recognition under different operational contexts.

Transfer of Complex Skill Learning from Virtual to Real Rowing

PubMed Central

Rauter, Georg; Sigrist, Roland; Koch, Claudio; Crivelli, Francesco; van Raai, Mark; Riener, Robert; Wolf, Peter

2013-01-01

Simulators are commonly used to train complex tasks. In particular, simulators are applied to train dangerous tasks, to save costs, and to investigate the impact of different factors on task performance. However, in most cases, the transfer of simulator training to the real task has not been investigated. Without a proof for successful skill transfer, simulators might not be helpful at all or even counter-productive for learning the real task. In this paper, the skill transfer of complex technical aspects trained on a scull rowing simulator to sculling on water was investigated. We assume if a simulator provides high fidelity rendering of the interactions with the environment even without augmented feedback, training on such a realistic simulator would allow similar skill gains as training in the real environment. These learned skills were expected to transfer to the real environment. Two groups of four recreational rowers participated. One group trained on water, the other group trained on a simulator. Within two weeks, both groups performed four training sessions with the same licensed rowing trainer. The development in performance was assessed by quantitative biomechanical performance measures and by a qualitative video evaluation of an independent, blinded trainer. In general, both groups could improve their performance on water. The used biomechanical measures seem to allow only a limited insight into the rowers' development, while the independent trainer could also rate the rowers' overall impression. The simulator quality and naturalism was confirmed by the participants in a questionnaire. In conclusion, realistic simulator training fostered skill gains to a similar extent as training in the real environment and enabled skill transfer to the real environment. In combination with augmented feedback, simulator training can be further exploited to foster motor learning even to a higher extent, which is subject to future work. PMID:24376518

A proposal for an open source graphical environment for simulating x-ray optics

NASA Astrophysics Data System (ADS)

Sanchez del Rio, Manuel; Rebuffi, Luca; Demsar, Janez; Canestrari, Niccolo; Chubar, Oleg

2014-09-01

A new graphic environment to drive X-ray optics simulation packages such as SHADOW and SRW is proposed. The aim is to simulate a virtual experiment, including the description of the electron beam and simulate the emitted radiation, the optics, the scattering by the sample and radiation detection. Python is chosen as common interaction language. The ingredients of the new application, a glossary of variables for optical component, the selection of visualization tools, and the integration of all these components in a high level workflow environment built on Orange are presented.

Physical Models and Virtual Reality Simulators in Otolaryngology.

PubMed

Javia, Luv; Sardesai, Maya G

2017-10-01

The increasing role of simulation in the medical education of future otolaryngologists has followed suit with other surgical disciplines. Simulators make it possible for the resident to explore and learn in a safe and less stressful environment. The various subspecialties in otolaryngology use physical simulators and virtual-reality simulators. Although physical simulators allow the operator to make direct contact with its components, virtual-reality simulators allow the operator to interact with an environment that is computer generated. This article gives an overview of the various types of physical simulators and virtual-reality simulators used in otolaryngology that have been reported in the literature. Copyright © 2017 Elsevier Inc. All rights reserved.

The evolution of the simulation environment in the ALMA Observatory

NASA Astrophysics Data System (ADS)

Shen, Tzu-Chiang; Soto, Ruben; Saez, Norman; Velez, Gaston; Staig, Tomas; Sepulveda, Jorge; Saez, Alejandro; Ovando, Nicolas; Ibsen, Jorge

2016-07-01

The Atacama Large Millimeter /submillimeter Array (ALMA) has entered into operation phase since 2013. This transition changed the priorities within the observatory, in which, most of the available time will be dedicated to science observations at the expense of technical time. Therefore, it was planned to design and implement a new simulation environment, which must be comparable - or at least- be representative of the production environment. Concepts of model in the loop and hardware in the loop were explored. In this paper we review experiences gained and lessons learnt during the design and implementation of the new simulation environment.

A novel approach to simulate gene-environment interactions in complex diseases.

PubMed

Amato, Roberto; Pinelli, Michele; D'Andrea, Daniel; Miele, Gennaro; Nicodemi, Mario; Raiconi, Giancarlo; Cocozza, Sergio

2010-01-05

Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc.). Despite a large amount of information that has been collected about both genetic and environmental risk factors, there are few examples of studies on their interactions in epidemiological literature. One reason can be the incomplete knowledge of the power of statistical methods designed to search for risk factors and their interactions in these data sets. An improvement in this direction would lead to a better understanding and description of gene-environment interactions. To this aim, a possible strategy is to challenge the different statistical methods against data sets where the underlying phenomenon is completely known and fully controllable, for example simulated ones. We present a mathematical approach that models gene-environment interactions. By this method it is possible to generate simulated populations having gene-environment interactions of any form, involving any number of genetic and environmental factors and also allowing non-linear interactions as epistasis. In particular, we implemented a simple version of this model in a Gene-Environment iNteraction Simulator (GENS), a tool designed to simulate case-control data sets where a one gene-one environment interaction influences the disease risk. The main aim has been to allow the input of population characteristics by using standard epidemiological measures and to implement constraints to make the simulator behaviour biologically meaningful. By the multi-logistic model implemented in GENS it is possible to simulate case-control samples of complex disease where gene-environment interactions influence the disease risk. The user has full control of the main characteristics of the simulated population and a Monte Carlo process allows random variability. A knowledge-based approach reduces the complexity of the mathematical model by using reasonable biological constraints and makes the simulation more understandable in biological terms. Simulated data sets can be used for the assessment of novel statistical methods or for the evaluation of the statistical power when designing a study.

Temperature Modulates the Effects of Ocean Acidification on Intestinal Ion Transport in Atlantic Cod, Gadus morhua

PubMed Central

Hu, Marian Y.; Michael, Katharina; Kreiss, Cornelia M.; Stumpp, Meike; Dupont, Sam; Tseng, Yung-Che; Lucassen, Magnus

2016-01-01

CO2-driven seawater acidification has been demonstrated to enhance intestinal bicarbonate secretion rates in teleosts, leading to an increased release of CaCO3 under simulated ocean acidification scenarios. In this study, we investigated if increasing CO2 levels stimulate the intestinal acid–base regulatory machinery of Atlantic cod (Gadus morhua) and whether temperatures at the upper limit of thermal tolerance stimulate or counteract ion regulatory capacities. Juvenile G. morhua were acclimated for 4 weeks to three CO2 levels (550, 1200, and 2200 μatm) covering present and near-future natural variability, at optimum (10°C) and summer maximum temperature (18°C), respectively. Immunohistochemical analyses revealed the subcellular localization of ion transporters, including Na+/K+-ATPase (NKA), Na+/H+-exchanger 3 (NHE3), Na+/HCO3− cotransporter (NBC1), pendrin-like Cl−/HCO3− exchanger (SLC26a6), V-type H+-ATPase subunit a (VHA), and Cl− channel 3 (CLC3) in epithelial cells of the anterior intestine. At 10°C, proteins and mRNA were generally up-regulated for most transporters in the intestinal epithelium after acclimation to higher CO2 levels. This supports recent findings demonstrating increased intestinal HCO3− secretion rates in response to CO2 induced seawater acidification. At 18°C, mRNA expression and protein concentrations of most ion transporters remained unchanged or were even decreased, suggesting thermal compensation. This response may be energetically favorable to retain blood HCO3− levels to stabilize pHe, but may negatively affect intestinal salt and water resorption of marine teleosts in future oceans. PMID:27313538

Temperature Modulates the Effects of Ocean Acidification on Intestinal Ion Transport in Atlantic Cod, Gadus morhua.

PubMed

Hu, Marian Y; Michael, Katharina; Kreiss, Cornelia M; Stumpp, Meike; Dupont, Sam; Tseng, Yung-Che; Lucassen, Magnus

2016-01-01

CO2-driven seawater acidification has been demonstrated to enhance intestinal bicarbonate secretion rates in teleosts, leading to an increased release of CaCO3 under simulated ocean acidification scenarios. In this study, we investigated if increasing CO2 levels stimulate the intestinal acid-base regulatory machinery of Atlantic cod (Gadus morhua) and whether temperatures at the upper limit of thermal tolerance stimulate or counteract ion regulatory capacities. Juvenile G. morhua were acclimated for 4 weeks to three CO2 levels (550, 1200, and 2200 μatm) covering present and near-future natural variability, at optimum (10°C) and summer maximum temperature (18°C), respectively. Immunohistochemical analyses revealed the subcellular localization of ion transporters, including Na(+)/K(+)-ATPase (NKA), Na(+)/H(+)-exchanger 3 (NHE3), Na(+)/[Formula: see text] cotransporter (NBC1), pendrin-like Cl(-)/[Formula: see text] exchanger (SLC26a6), V-type H(+)-ATPase subunit a (VHA), and Cl(-) channel 3 (CLC3) in epithelial cells of the anterior intestine. At 10°C, proteins and mRNA were generally up-regulated for most transporters in the intestinal epithelium after acclimation to higher CO2 levels. This supports recent findings demonstrating increased intestinal [Formula: see text] secretion rates in response to CO2 induced seawater acidification. At 18°C, mRNA expression and protein concentrations of most ion transporters remained unchanged or were even decreased, suggesting thermal compensation. This response may be energetically favorable to retain blood [Formula: see text] levels to stabilize pHe, but may negatively affect intestinal salt and water resorption of marine teleosts in future oceans.

The Energy-Environment Simulator as a Classroom Aid.

ERIC Educational Resources Information Center

Sell, Nancy J.; Van Koevering, Thomas E.

1981-01-01

Energy-Environment Simulators, provided by the U.S. Department of Energy, can be used to help individuals experience the effects of unbridled energy consumption for the next century on a national or worldwide scale. The simulator described is a specially designed analog computer which models the real-world energy situation. (MP)

Simulation as a Method of Teaching Communication for Multinational Corporations.

ERIC Educational Resources Information Center

Stull, James B.; Baird, John W.

Interpersonal simulations may be used as a module in cultural awareness programs to provide realistic environments in which students, supervisors, and managers may practice communication skills that are effective in multicultural environments. To conduct and implement a cross-cultural simulation, facilitators should proceed through four stages:…

Designing, Implementing and Evaluating Preclinical Simulation Lab for Maternity Nursing Course

ERIC Educational Resources Information Center

ALFozan, Haya; El Sayed, Yousria; Habib, Farida

2015-01-01

Background: The opportunity for students to deliver care safely in today's, complex health care environment is limited. Simulation allows students to practice skills in a safe environment. Purpose: to assess the students' perception, satisfaction, and learning outcomes after a simulation based maternity course. Method: a quasi experimental design…

A Distributed Simulation Facility to Support Human Factors Research in Advanced Air Transportation Technology

NASA Technical Reports Server (NTRS)

Amonlirdviman, Keith; Farley, Todd C.; Hansman, R. John, Jr.; Ladik, John F.; Sherer, Dana Z.

1998-01-01

A distributed real-time simulation of the civil air traffic environment developed to support human factors research in advanced air transportation technology is presented. The distributed environment is based on a custom simulation architecture designed for simplicity and flexibility in human experiments. Standard Internet protocols are used to create the distributed environment, linking all advanced cockpit simulator, all Air Traffic Control simulator, and a pseudo-aircraft control and simulation management station. The pseudo-aircraft control station also functions as a scenario design tool for coordinating human factors experiments. This station incorporates a pseudo-pilot interface designed to reduce workload for human operators piloting multiple aircraft simultaneously in real time. The application of this distributed simulation facility to support a study of the effect of shared information (via air-ground datalink) on pilot/controller shared situation awareness and re-route negotiation is also presented.

An Integrated Modeling and Simulation Methodology for Intelligent Systems Design and Testing

DTIC Science & Technology

2002-08-01

simulation and actual execution. KEYWORDS: Model Continuity, Modeling, Simulation, Experimental Frame, Real Time Systems , Intelligent Systems...the methodology for a stand-alone real time system. Then it will scale up to distributed real time systems . For both systems, step-wise simulation...MODEL CONTINUITY Intelligent real time systems monitor, respond to, or control, an external environment. This environment is connected to the digital

Exploration of Force Transition in Stability Operations Using Multi-Agent Simulation

DTIC Science & Technology

2006-09-01

risk, mission failure risk, and time in the context of the operational threat environment. The Pythagoras Multi-Agent Simulation and Data Farming...NUMBER OF PAGES 173 14. SUBJECT TERMS Stability Operations, Peace Operations, Data Farming, Pythagoras , Agent- Based Model, Multi-Agent Simulation...the operational threat environment. The Pythagoras Multi-Agent Simulation and Data Farming techniques are used to investigate force-level

Simulation of Range Safety for the NASA Space Shuttle

NASA Technical Reports Server (NTRS)

Rabelo, Luis; Sepulveda, Jose; Compton, Jeppie; Turner, Robert

2005-01-01

This paper describes a simulation environment that seamlessly combines a number of safety and environmental models for the launch phase of a NASA Space Shuttle mission. The components of this simulation environment represent the different systems that must interact in order to determine the Expectation of casualties (E(sub c)) resulting from the toxic effects of the gas dispersion that occurs after a disaster affecting a Space Shuttle within 120 seconds of lift-off. The utilization of the Space Shuttle reliability models, trajectory models, weather dissemination systems, population models, amount and type of toxicants, gas dispersion models, human response functions to toxicants, and a geographical information system are all integrated to create this environment. This simulation environment can help safety managers estimate the population at risk in order to plan evacuation, make sheltering decisions, determine the resources required to provide aid and comfort, and mitigate damages in case of a disaster. This simulation environment may also be modified and used for the landing phase of a space vehicle but will not be discussed in this paper.

Visual Computing Environment

NASA Technical Reports Server (NTRS)

Lawrence, Charles; Putt, Charles W.

1997-01-01

The Visual Computing Environment (VCE) is a NASA Lewis Research Center project to develop a framework for intercomponent and multidisciplinary computational simulations. Many current engineering analysis codes simulate various aspects of aircraft engine operation. For example, existing computational fluid dynamics (CFD) codes can model the airflow through individual engine components such as the inlet, compressor, combustor, turbine, or nozzle. Currently, these codes are run in isolation, making intercomponent and complete system simulations very difficult to perform. In addition, management and utilization of these engineering codes for coupled component simulations is a complex, laborious task, requiring substantial experience and effort. To facilitate multicomponent aircraft engine analysis, the CFD Research Corporation (CFDRC) is developing the VCE system. This system, which is part of NASA's Numerical Propulsion Simulation System (NPSS) program, can couple various engineering disciplines, such as CFD, structural analysis, and thermal analysis. The objectives of VCE are to (1) develop a visual computing environment for controlling the execution of individual simulation codes that are running in parallel and are distributed on heterogeneous host machines in a networked environment, (2) develop numerical coupling algorithms for interchanging boundary conditions between codes with arbitrary grid matching and different levels of dimensionality, (3) provide a graphical interface for simulation setup and control, and (4) provide tools for online visualization and plotting. VCE was designed to provide a distributed, object-oriented environment. Mechanisms are provided for creating and manipulating objects, such as grids, boundary conditions, and solution data. This environment includes parallel virtual machine (PVM) for distributed processing. Users can interactively select and couple any set of codes that have been modified to run in a parallel distributed fashion on a cluster of heterogeneous workstations. A scripting facility allows users to dictate the sequence of events that make up the particular simulation.

Extensible Adaptable Simulation Systems: Supporting Multiple Fidelity Simulations in a Common Environment

NASA Technical Reports Server (NTRS)

McLaughlin, Brian J.; Barrett, Larry K.

2012-01-01

Common practice in the development of simulation systems is meeting all user requirements within a single instantiation. The Joint Polar Satellite System (JPSS) presents a unique challenge to establish a simulation environment that meets the needs of a diverse user community while also spanning a multi-mission environment over decades of operation. In response, the JPSS Flight Vehicle Test Suite (FVTS) is architected with an extensible infrastructure that supports the operation of multiple observatory simulations for a single mission and multiple mission within a common system perimeter. For the JPSS-1 satellite, multiple fidelity flight observatory simulations are necessary to support the distinct user communities consisting of the Common Ground System development team, the Common Ground System Integration & Test team, and the Mission Rehearsal Team/Mission Operations Team. These key requirements present several challenges to FVTS development. First, the FVTS must ensure all critical user requirements are satisfied by at least one fidelity instance of the observatory simulation. Second, the FVTS must allow for tailoring of the system instances to function in diverse operational environments from the High-security operations environment at NOAA Satellite Operations Facility (NSOF) to the ground system factory floor. Finally, the FVTS must provide the ability to execute sustaining engineering activities on a subset of the system without impacting system availability to parallel users. The FVTS approach of allowing for multiple fidelity copies of observatory simulations represents a unique concept in simulator capability development and corresponds to the JPSS Ground System goals of establishing a capability that is flexible, extensible, and adaptable.

Gaining insight into the physics of dynamic atomic force microscopy in complex environments using the VEDA simulator

NASA Astrophysics Data System (ADS)

Kiracofe, Daniel; Melcher, John; Raman, Arvind

2012-01-01

Dynamic atomic force microscopy (dAFM) continues to grow in popularity among scientists in many different fields, and research on new methods and operating modes continues to expand the resolution, capabilities, and types of samples that can be studied. But many promising increases in capability are accompanied by increases in complexity. Indeed, interpreting modern dAFM data can be challenging, especially on complicated material systems, or in liquid environments where the behavior is often contrary to what is known in air or vacuum environments. Mathematical simulations have proven to be an effective tool in providing physical insight into these non-intuitive systems. In this article we describe recent developments in the VEDA (virtual environment for dynamic AFM) simulator, which is a suite of freely available, open-source simulation tools that are delivered through the cloud computing cyber-infrastructure of nanoHUB (www.nanohub.org). Here we describe three major developments. First, simulations in liquid environments are improved by enhancements in the modeling of cantilever dynamics, excitation methods, and solvation shell forces. Second, VEDA is now able to simulate many new advanced modes of operation (bimodal, phase-modulation, frequency-modulation, etc.). Finally, nineteen different tip-sample models are available to simulate the surface physics of a wide variety different material systems including capillary, specific adhesion, van der Waals, electrostatic, viscoelasticity, and hydration forces. These features are demonstrated through example simulations and validated against experimental data, in order to provide insight into practical problems in dynamic AFM.

Gaining insight into the physics of dynamic atomic force microscopy in complex environments using the VEDA simulator.

PubMed

Kiracofe, Daniel; Melcher, John; Raman, Arvind

2012-01-01

Dynamic atomic force microscopy (dAFM) continues to grow in popularity among scientists in many different fields, and research on new methods and operating modes continues to expand the resolution, capabilities, and types of samples that can be studied. But many promising increases in capability are accompanied by increases in complexity. Indeed, interpreting modern dAFM data can be challenging, especially on complicated material systems, or in liquid environments where the behavior is often contrary to what is known in air or vacuum environments. Mathematical simulations have proven to be an effective tool in providing physical insight into these non-intuitive systems. In this article we describe recent developments in the VEDA (virtual environment for dynamic AFM) simulator, which is a suite of freely available, open-source simulation tools that are delivered through the cloud computing cyber-infrastructure of nanoHUB (www.nanohub.org). Here we describe three major developments. First, simulations in liquid environments are improved by enhancements in the modeling of cantilever dynamics, excitation methods, and solvation shell forces. Second, VEDA is now able to simulate many new advanced modes of operation (bimodal, phase-modulation, frequency-modulation, etc.). Finally, nineteen different tip-sample models are available to simulate the surface physics of a wide variety different material systems including capillary, specific adhesion, van der Waals, electrostatic, viscoelasticity, and hydration forces. These features are demonstrated through example simulations and validated against experimental data, in order to provide insight into practical problems in dynamic AFM.

Cognitive simulators for medical education and training.

PubMed

Kahol, Kanav; Vankipuram, Mithra; Smith, Marshall L

2009-08-01

Simulators for honing procedural skills (such as surgical skills and central venous catheter placement) have proven to be valuable tools for medical educators and students. While such simulations represent an effective paradigm in surgical education, there is an opportunity to add a layer of cognitive exercises to these basic simulations that can facilitate robust skill learning in residents. This paper describes a controlled methodology, inspired by neuropsychological assessment tasks and embodied cognition, to develop cognitive simulators for laparoscopic surgery. These simulators provide psychomotor skill training and offer the additional challenge of accomplishing cognitive tasks in realistic environments. A generic framework for design, development and evaluation of such simulators is described. The presented framework is generalizable and can be applied to different task domains. It is independent of the types of sensors, simulation environment and feedback mechanisms that the simulators use. A proof of concept of the framework is provided through developing a simulator that includes cognitive variations to a basic psychomotor task. The results of two pilot studies are presented that show the validity of the methodology in providing an effective evaluation and learning environments for surgeons.

Simulation environment and graphical visualization environment: a COPD use-case

PubMed Central

2014-01-01

Background Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which in turn simplify the communication among models. Nevertheless, not all of these tools are able to run models written in different programming languages. In addition, interoperability between such models remains an unresolved issue. Results In this paper we present a simulation environment that allows, first, the execution of models developed in different programming languages and second the communication of parameters to interconnect these models. This simulation environment, developed within the Synergy-COPD project, aims at helping and supporting bio-researchers and medical students understand the internal mechanisms of the human body through the use of physiological models. This tool is composed of a graphical visualization environment, which is a web interface through which the user can interact with the models, and a simulation workflow management system composed of a control module and a data warehouse manager. The control module monitors the correct functioning of the whole system. The data warehouse manager is responsible for managing the stored information and supporting its flow among the different modules. This simulation environment has been validated with the integration of three models: two deterministic, i.e. based on linear and differential equations, and one probabilistic, i.e., based on probability theory. These models have been selected based on the disease under study in this project, i.e., chronic obstructive pulmonary disease. Conclusion It has been proved that the simulation environment presented here allows the user to research and study the internal mechanisms of the human physiology by the use of models via a graphical visualization environment. A new tool for bio-researchers is ready for deployment in various use cases scenarios. PMID:25471327

Simulation at the point of care: reduced-cost, in situ training via a mobile cart.

PubMed

Weinstock, Peter H; Kappus, Liana J; Garden, Alexander; Burns, Jeffrey P

2009-03-01

The rapid growth of simulation in health care has challenged traditional paradigms of hospital-based education and training. Simulation addresses patient safety through deliberative practice of high-risk low-frequency events within a safe, structured environment. Despite its inherent appeal, widespread adoption of simulation is prohibited by high cost, limited space, interruptions to clinical duties, and the inability to replicate important nuances of clinical environments. We therefore sought to develop a reduced-cost low-space mobile cart to provide realistic simulation experiences to a range of providers within the clinical environment and to serve as a model for transportable, cost-effective, widespread simulation-based training of bona-fide workplace teams. Descriptive study. A tertiary care pediatric teaching hospital. A self-contained mobile simulation cart was constructed at a cost of $8054 (mannequin not included). The cart is compatible with any mannequin and contains all equipment needed to produce a high quality simulation experience equivalent to that of our on-site center--including didactics and debriefing with videotaped recordings complete with vital sign overlay. Over a 3-year period the cart delivered 57 courses to 425 participants from five pediatric departments. All individuals were trained among their native teams and within their own clinical environment. By bringing all pedagogical elements to the actual clinical environment, a mobile cart can provide simulation to hospital teams that might not otherwise benefit from the educational tool. By reducing the setup cost and the need for dedicated space, the mobile approach provides a mechanism to increase the number of institutions capable of harnessing the power of simulation-based education internationally.

Spacecraft VHF Radio Propagation Analysis in Ocean Environments Including Atmospheric Effects

NASA Technical Reports Server (NTRS)

Hwu, Shian; Moreno, Gerardo; Desilva, Kanishka; Jih, CIndy

2010-01-01

The Communication Systems Simulation Laboratory (CSSL) at the National Aeronautics and Space Administration (NASA)/Johnson Space Center (JSC) is tasked to perform spacecraft and ground network communication system simulations. The CSSL has developed simulation tools that model spacecraft communication systems and the space/ground environment in which they operate. This paper is to analyze a spacecraft's very high frequency (VHF) radio signal propagation and the impact to performance when landing in an ocean. Very little research work has been done for VHF radio systems in a maritime environment. Rigorous Radio Frequency (RF) modeling/simulation techniques were employed for various environmental effects. The simulation results illustrate the significance of the environmental effects on the VHF radio system performance.

Multifluid MHD Simulations of the Plasma Environment of Comet Churyumov-Gerasimenko at Different Heliocentric Distances

NASA Astrophysics Data System (ADS)

Huang, Z.; Jia, X.; Rubin, M.; Fougere, N.; Gombosi, T. I.; Tenishev, V.; Combi, M. R.; Bieler, A. M.; Toth, G.; Hansen, K. C.; Shou, Y.

2014-12-01

We study the plasma environment of the comet Churyumov-Gerasimenko, which is the target of the Rosetta mission, by performing large scale numerical simulations. Our model is based on BATS-R-US within the Space Weather Modeling Framework that solves the governing multifluid MHD equations, which describe the behavior of the cometary heavy ions, the solar wind protons, and electrons. The model includes various mass loading processes, including ionization, charge exchange, dissociative ion-electron recombination, as well as collisional interactions between different fluids. The neutral background used in our MHD simulations is provided by a kinetic Direct Simulation Monte Carlo (DSMC) model. We will simulate how the cometary plasma environment changes at different heliocentric distances.

Computer and laboratory simulation of interactions between spacecraft surfaces and charged-particle environments

NASA Technical Reports Server (NTRS)

Stevens, N. J.

1979-01-01

Cases where the charged-particle environment acts on the spacecraft (e.g., spacecraft charging phenomena) and cases where a system on the spacecraft causes the interaction (e.g., high voltage space power systems) are considered. Both categories were studied in ground simulation facilities to understand the processes involved and to measure the pertinent parameters. Computer simulations are based on the NASA Charging Analyzer Program (NASCAP) code. Analytical models are developed in this code and verified against the experimental data. Extrapolation from the small test samples to space conditions are made with this code. Typical results from laboratory and computer simulations are presented for both types of interactions. Extrapolations from these simulations to performance in space environments are discussed.

Interactive Web-based Floodplain Simulation System for Realistic Experiments of Flooding and Flood Damage

NASA Astrophysics Data System (ADS)

Demir, I.

2013-12-01

Recent developments in web technologies make it easy to manage and visualize large data sets with general public. Novel visualization techniques and dynamic user interfaces allow users to create realistic environments, and interact with data to gain insight from simulations and environmental observations. The floodplain simulation system is a web-based 3D interactive flood simulation environment to create real world flooding scenarios. The simulation systems provides a visually striking platform with realistic terrain information, and water simulation. Students can create and modify predefined scenarios, control environmental parameters, and evaluate flood mitigation techniques. The web-based simulation system provides an environment to children and adults learn about the flooding, flood damage, and effects of development and human activity in the floodplain. The system provides various scenarios customized to fit the age and education level of the users. This presentation provides an overview of the web-based flood simulation system, and demonstrates the capabilities of the system for various flooding and land use scenarios.

Automatic programming of simulation models

NASA Technical Reports Server (NTRS)

Schroer, Bernard J.; Tseng, Fan T.; Zhang, Shou X.; Dwan, Wen S.

1988-01-01

The objective of automatic programming is to improve the overall environment for describing the program. This improved environment is realized by a reduction in the amount of detail that the programmer needs to know and is exposed to. Furthermore, this improved environment is achieved by a specification language that is more natural to the user's problem domain and to the user's way of thinking and looking at the problem. The goal of this research is to apply the concepts of automatic programming (AP) to modeling discrete event simulation system. Specific emphasis is on the design and development of simulation tools to assist the modeler define or construct a model of the system and to then automatically write the corresponding simulation code in the target simulation language, GPSS/PC. A related goal is to evaluate the feasibility of various languages for constructing automatic programming simulation tools.

Gamma ray observatory dynamics simulator in Ada (GRODY)

NASA Technical Reports Server (NTRS)

1990-01-01

This experiment involved the parallel development of dynamics simulators for the Gamma Ray Observatory in both FORTRAN and Ada for the purpose of evaluating the applicability of Ada to the NASA/Goddard Space Flight Center's flight dynamics environment. The experiment successfully demonstrated that Ada is a viable, valuable technology for use in this environment. In addition to building a simulator, the Ada team evaluated training approaches, developed an Ada methodology appropriate to the flight dynamics environment, and established a baseline for evaluating future Ada projects.

The Trick Simulation Toolkit: A NASA/Open source Framework for Running Time Based Physics Models

NASA Technical Reports Server (NTRS)

Penn, John M.; Lin, Alexander S.

2016-01-01

This paper describes the design and use at of the Trick Simulation Toolkit, a simulation development environment for creating high fidelity training and engineering simulations at the NASA Johnson Space Center and many other NASA facilities. It describes Trick's design goals and how the development environment attempts to achieve those goals. It describes how Trick is used in some of the many training and engineering simulations at NASA. Finally it describes the Trick NASA/Open source project on Github.

Interactive Learning Environment: Web-based Virtual Hydrological Simulation System using Augmented and Immersive Reality

NASA Astrophysics Data System (ADS)

Demir, I.

2014-12-01

Recent developments in internet technologies make it possible to manage and visualize large data on the web. Novel visualization techniques and interactive user interfaces allow users to create realistic environments, and interact with data to gain insight from simulations and environmental observations. The hydrological simulation system is a web-based 3D interactive learning environment for teaching hydrological processes and concepts. The simulation systems provides a visually striking platform with realistic terrain information, and water simulation. Students can create or load predefined scenarios, control environmental parameters, and evaluate environmental mitigation alternatives. The web-based simulation system provides an environment for students to learn about the hydrological processes (e.g. flooding and flood damage), and effects of development and human activity in the floodplain. The system utilizes latest web technologies and graphics processing unit (GPU) for water simulation and object collisions on the terrain. Users can access the system in three visualization modes including virtual reality, augmented reality, and immersive reality using heads-up display. The system provides various scenarios customized to fit the age and education level of various users. This presentation provides an overview of the web-based flood simulation system, and demonstrates the capabilities of the system for various visualization and interaction modes.

Teaching Harmonic Motion in Trigonometry: Inductive Inquiry Supported by Physics Simulations

ERIC Educational Resources Information Center

Sokolowski, Andrzej; Rackley, Robin

2011-01-01

In this article, the authors present a lesson whose goal is to utilise a scientific environment to immerse a trigonometry student in the process of mathematical modelling. The scientific environment utilised during this activity is a physics simulation called "Wave on a String" created by the PhET Interactive Simulations Project at…

Students' Expectations of the Learning Process in Virtual Reality and Simulation-Based Learning Environments

ERIC Educational Resources Information Center

Keskitalo, Tuulikki

2012-01-01

Expectations for simulations in healthcare education are high; however, little is known about healthcare students' expectations of the learning process in virtual reality (VR) and simulation-based learning environments (SBLEs). This research aims to describe first-year healthcare students' (N=97) expectations regarding teaching, studying, and…

The Virtual Environment for Rapid Prototyping of the Intelligent Environment

PubMed Central

Bouzouane, Abdenour; Gaboury, Sébastien

2017-01-01

Advances in domains such as sensor networks and electronic and ambient intelligence have allowed us to create intelligent environments (IEs). However, research in IE is being held back by the fact that researchers face major difficulties, such as a lack of resources for their experiments. Indeed, they cannot easily build IEs to evaluate their approaches. This is mainly because of economic and logistical issues. In this paper, we propose a simulator to build virtual IEs. Simulators are a good alternative to physical IEs because they are inexpensive, and experiments can be conducted easily. Our simulator is open source and it provides users with a set of virtual sensors that simulates the behavior of real sensors. This simulator gives the user the capacity to build their own environment, providing a model to edit inhabitants’ behavior and an interactive mode. In this mode, the user can directly act upon IE objects. This simulator gathers data generated by the interactions in order to produce datasets. These datasets can be used by scientists to evaluate several approaches in IEs. PMID:29112175

Translating the simulation of procedural drilling techniques for interactive neurosurgical training.

PubMed

Stredney, Don; Rezai, Ali R; Prevedello, Daniel M; Elder, J Bradley; Kerwin, Thomas; Hittle, Bradley; Wiet, Gregory J

2013-10-01

Through previous efforts we have developed a fully virtual environment to provide procedural training of otologic surgical technique. The virtual environment is based on high-resolution volumetric data of the regional anatomy. These volumetric data help drive an interactive multisensory, ie, visual (stereo), aural (stereo), and tactile, simulation environment. Subsequently, we have extended our efforts to support the training of neurosurgical procedural technique as part of the Congress of Neurological Surgeons simulation initiative. To deliberately study the integration of simulation technologies into the neurosurgical curriculum and to determine their efficacy in teaching minimally invasive cranial and skull base approaches. We discuss issues of biofidelity and our methods to provide objective, quantitative and automated assessment for the residents. We conclude with a discussion of our experiences by reporting preliminary formative pilot studies and proposed approaches to take the simulation to the next level through additional validation studies. We have presented our efforts to translate an otologic simulation environment for use in the neurosurgical curriculum. We have demonstrated the initial proof of principles and define the steps to integrate and validate the system as an adjuvant to the neurosurgical curriculum.

GADEN: A 3D Gas Dispersion Simulator for Mobile Robot Olfaction in Realistic Environments.

PubMed

Monroy, Javier; Hernandez-Bennets, Victor; Fan, Han; Lilienthal, Achim; Gonzalez-Jimenez, Javier

2017-06-23

This work presents a simulation framework developed under the widely used Robot Operating System (ROS) to enable the validation of robotics systems and gas sensing algorithms under realistic environments. The framework is rooted in the principles of computational fluid dynamics and filament dispersion theory, modeling wind flow and gas dispersion in 3D real-world scenarios (i.e., accounting for walls, furniture, etc.). Moreover, it integrates the simulation of different environmental sensors, such as metal oxide gas sensors, photo ionization detectors, or anemometers. We illustrate the potential and applicability of the proposed tool by presenting a simulation case in a complex and realistic office-like environment where gas leaks of different chemicals occur simultaneously. Furthermore, we accomplish quantitative and qualitative validation by comparing our simulated results against real-world data recorded inside a wind tunnel where methane was released under different wind flow profiles. Based on these results, we conclude that our simulation framework can provide a good approximation to real world measurements when advective airflows are present in the environment.

GADEN: A 3D Gas Dispersion Simulator for Mobile Robot Olfaction in Realistic Environments

PubMed Central

Hernandez-Bennetts, Victor; Fan, Han; Lilienthal, Achim; Gonzalez-Jimenez, Javier

2017-01-01

This work presents a simulation framework developed under the widely used Robot Operating System (ROS) to enable the validation of robotics systems and gas sensing algorithms under realistic environments. The framework is rooted in the principles of computational fluid dynamics and filament dispersion theory, modeling wind flow and gas dispersion in 3D real-world scenarios (i.e., accounting for walls, furniture, etc.). Moreover, it integrates the simulation of different environmental sensors, such as metal oxide gas sensors, photo ionization detectors, or anemometers. We illustrate the potential and applicability of the proposed tool by presenting a simulation case in a complex and realistic office-like environment where gas leaks of different chemicals occur simultaneously. Furthermore, we accomplish quantitative and qualitative validation by comparing our simulated results against real-world data recorded inside a wind tunnel where methane was released under different wind flow profiles. Based on these results, we conclude that our simulation framework can provide a good approximation to real world measurements when advective airflows are present in the environment. PMID:28644375

The Virtual Environment for Rapid Prototyping of the Intelligent Environment.

PubMed

Francillette, Yannick; Boucher, Eric; Bouzouane, Abdenour; Gaboury, Sébastien

2017-11-07

Advances in domains such as sensor networks and electronic and ambient intelligence have allowed us to create intelligent environments (IEs). However, research in IE is being held back by the fact that researchers face major difficulties, such as a lack of resources for their experiments. Indeed, they cannot easily build IEs to evaluate their approaches. This is mainly because of economic and logistical issues. In this paper, we propose a simulator to build virtual IEs. Simulators are a good alternative to physical IEs because they are inexpensive, and experiments can be conducted easily. Our simulator is open source and it provides users with a set of virtual sensors that simulates the behavior of real sensors. This simulator gives the user the capacity to build their own environment, providing a model to edit inhabitants' behavior and an interactive mode. In this mode, the user can directly act upon IE objects. This simulator gathers data generated by the interactions in order to produce datasets. These datasets can be used by scientists to evaluate several approaches in IEs.

SPEEDES - A multiple-synchronization environment for parallel discrete-event simulation

NASA Technical Reports Server (NTRS)

Steinman, Jeff S.

1992-01-01

Synchronous Parallel Environment for Emulation and Discrete-Event Simulation (SPEEDES) is a unified parallel simulation environment. It supports multiple-synchronization protocols without requiring users to recompile their code. When a SPEEDES simulation runs on one node, all the extra parallel overhead is removed automatically at run time. When the same executable runs in parallel, the user preselects the synchronization algorithm from a list of options. SPEEDES currently runs on UNIX networks and on the California Institute of Technology/Jet Propulsion Laboratory Mark III Hypercube. SPEEDES also supports interactive simulations. Featured in the SPEEDES environment is a new parallel synchronization approach called Breathing Time Buckets. This algorithm uses some of the conservative techniques found in Time Bucket synchronization, along with the optimism that characterizes the Time Warp approach. A mathematical model derived from first principles predicts the performance of Breathing Time Buckets. Along with the Breathing Time Buckets algorithm, this paper discusses the rules for processing events in SPEEDES, describes the implementation of various other synchronization protocols supported by SPEEDES, describes some new ones for the future, discusses interactive simulations, and then gives some performance results.

[Research progress and development trend of quantitative assessment techniques for urban thermal environment.

PubMed

Sun, Tie Gang; Xiao, Rong Bo; Cai, Yun Nan; Wang, Yao Wu; Wu, Chang Guang

2016-08-01

Quantitative assessment of urban thermal environment has become a focus for urban climate and environmental science since the concept of urban heat island has been proposed. With the continual development of space information and computer simulation technology, substantial progresses have been made on quantitative assessment techniques and methods of urban thermal environment. The quantitative assessment techniques have been developed to dynamics simulation and forecast of thermal environment at various scales based on statistical analysis of thermal environment on urban-scale using the historical data of weather stations. This study reviewed the development progress of ground meteorological observation, thermal infrared remote sensing and numerical simulation. Moreover, the potential advantages and disadvantages, applicability and the development trends of these techniques were also summarized, aiming to add fundamental knowledge of understanding the urban thermal environment assessment and optimization.

Design of a simulation environment for laboratory management by robot organizations

NASA Technical Reports Server (NTRS)

Zeigler, Bernard P.; Cellier, Francois E.; Rozenblit, Jerzy W.

1988-01-01

This paper describes the basic concepts needed for a simulation environment capable of supporting the design of robot organizations for managing chemical, or similar, laboratories on the planned U.S. Space Station. The environment should facilitate a thorough study of the problems to be encountered in assigning the responsibility of managing a non-life-critical, but mission valuable, process to an organized group of robots. In the first phase of the work, we seek to employ the simulation environment to develop robot cognitive systems and strategies for effective multi-robot management of chemical experiments. Later phases will explore human-robot interaction and development of robot autonomy.

Simulating The Dynamical Evolution Of Galaxies In Group And Cluster Environments

NASA Astrophysics Data System (ADS)

Vijayaraghavan, Rukmani

2015-07-01

Galaxy clusters are harsh environments for their constituent galaxies. A variety of physical processes effective in these dense environments transform gas-rich, spiral, star-forming galaxies to elliptical or spheroidal galaxies with very little gas and therefore minimal star formation. The consequences of these processes are well understood observationally. Galaxies in progressively denser environments have systematically declining star formation rates and gas content. However, a theoretical understanding of of where, when, and how these processes act, and the interplay between the various galaxy transformation mechanisms in clusters remains elusive. In this dissertation, I use numerical simulations of cluster mergers as well as galaxies evolving in quiescent environments to develop a theoretical framework to understand some of the physics of galaxy transformation in cluster environments. Galaxies can be transformed in smaller groups before they are accreted by their eventual massive cluster environments, an effect termed `pre-processing'. Galaxy cluster mergers themselves can accelerate many galaxy transformation mechanisms, including tidal and ram pressure stripping of galaxies and galaxy-galaxy collisions and mergers that result in reassemblies of galaxies' stars and gas. Observationally, cluster mergers have distinct velocity and phase-space signatures depending on the observer's line of sight with respect to the merger direction. Using dark matter only as well as hydrodynamic simulations of cluster mergers with random ensembles of particles tagged with galaxy models, I quantify the effects of cluster mergers on galaxy evolution before, during, and after the mergers. Based on my theoretical predictions of the dynamical signatures of these mergers in combination with galaxy transformation signatures, one can observationally identify remnants of mergers and quantify the effect of the environment on galaxies in dense group and cluster environments. The presence of long-lived, hot X-ray emitting coronae observed in a large fraction of group and cluster galaxies is not well-understood. These coronae are not fully stripped by ram pressure and tidal forces that are efficient in these environments. Theoretically, this is a fascinating and challenging problem that involves understanding and simulating the multitude of physical processes in these dense environments that can remove or replenish galaxies' hot coronae. To solve this problem, I have developed and implemented a robust simulation technique where I simulate the evolution of a realistic cluster environment with a population of galaxies and their gas. With this technique, it is possible to isolate and quantify the importance of the various cluster physical processes for coronal survival. To date, I have performed hydrodynamic simulations of galaxies being ram pressure stripped in quiescent group and cluster environments. Using these simulations, I have characterized the physics of ram pressure stripping and investigated the survival of these coronae in the presence of tidal and ram pressure stripping. I have also generated synthetic X-ray observations of these simulated systems to compare with observed coronae. I have also performed magnetohydrodynamic simulations of galaxies evolving in a magnetized intracluster medium plasma to isolate the effect of magnetic fields on coronal evolution, as well the effect of orbiting galaxies in amplifying magnetic fields. This work is an important step towards understanding the effect of cluster environments on galactic gas, and consequently, their long term evolution and impact on star formation rates.

Efficient radiologic reading environment by using an open-source macro program as connection software.

PubMed

Lee, Young Han

2012-01-01

The objectives are (1) to introduce an easy open-source macro program as connection software and (2) to illustrate the practical usages in radiologic reading environment by simulating the radiologic reading process. The simulation is a set of radiologic reading process to do a practical task in the radiologic reading room. The principal processes are: (1) to view radiologic images on the Picture Archiving and Communicating System (PACS), (2) to connect the HIS/EMR (Hospital Information System/Electronic Medical Record) system, (3) to make an automatic radiologic reporting system, and (4) to record and recall information of interesting cases. This simulation environment was designed by using open-source macro program as connection software. The simulation performed well on the Window-based PACS workstation. Radiologists practiced the steps of the simulation comfortably by utilizing the macro-powered radiologic environment. This macro program could automate several manual cumbersome steps in the radiologic reading process. This program successfully acts as connection software for the PACS software, EMR/HIS, spreadsheet, and other various input devices in the radiologic reading environment. A user-friendly efficient radiologic reading environment could be established by utilizing open-source macro program as connection software. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Feasibility analysis on integration of luminous environment measuring and design based on exposure curve calibration

NASA Astrophysics Data System (ADS)

Zou, Yuan; Shen, Tianxing

2013-03-01

Besides illumination calculating during architecture and luminous environment design, to provide more varieties of photometric data, the paper presents combining relation between luminous environment design and SM light environment measuring system, which contains a set of experiment devices including light information collecting and processing modules, and can offer us various types of photometric data. During the research process, we introduced a simulation method for calibration, which mainly includes rebuilding experiment scenes in 3ds Max Design, calibrating this computer aid design software in simulated environment under conditions of various typical light sources, and fitting the exposure curves of rendered images. As analytical research went on, the operation sequence and points for attention during the simulated calibration were concluded, connections between Mental Ray renderer and SM light environment measuring system were established as well. From the paper, valuable reference conception for coordination between luminous environment design and SM light environment measuring system was pointed out.

Apparatus and method for modifying the operation of a robotic vehicle in a real environment, to emulate the operation of the robotic vehicle operating in a mixed reality environment

DOEpatents

Garretson, Justin R [Albuquerque, NM; Parker, Eric P [Albuquerque, NM; Gladwell, T Scott [Albuquerque, NM; Rigdon, J Brian [Edgewood, NM; Oppel, III, Fred J.

2012-05-29

Apparatus and methods for modifying the operation of a robotic vehicle in a real environment to emulate the operation of the robotic vehicle in a mixed reality environment include a vehicle sensing system having a communications module attached to the robotic vehicle for communicating operating parameters related to the robotic vehicle in a real environment to a simulation controller for simulating the operation of the robotic vehicle in a mixed (live, virtual and constructive) environment wherein the affects of virtual and constructive entities on the operation of the robotic vehicle (and vice versa) are simulated. These effects are communicated to the vehicle sensing system which generates a modified control command for the robotic vehicle including the effects of virtual and constructive entities, causing the robot in the real environment to behave as if virtual and constructive entities existed in the real environment.

Optimal Living Environments for the Elderly: A Design Simulation Approach.

ERIC Educational Resources Information Center

Hoffman, Stephanie B.; And Others

PLANNED AGE (Planned Alternatives for Gerontological Environments) is a consumer/advocate-oriented design simulation package that provides: (a) a medium for user-planner interaction in the design of living and service environments for the aged; (b) an educational, planning, design, and evaluation tool that can be used by the elderly, their…

The Use of Visual-Based Simulated Environments in Teacher Preparation

ERIC Educational Resources Information Center

Judge, Sharon; Bobzien, Jonna; Maydosz, Ann; Gear, Sabra; Katsioloudis, Petros

2013-01-01

While virtual technology for training in the simulation field has a long history in medicine, aviation, and the military, the application of similar emerging and innovative technologies in teacher preparation and education has been limited. TLE TeachLive™ (Teaching Learning Environment, Teaching in a Virtual Environment) [TLE] is an inventive…

Gilded and gelded. Hard-won lessons from the PR wars.

PubMed

Martin, Dick

2003-10-01

A golden statue of a winged youth once perched on the roof of AT&T's old headquarters. But when AT&T lowered the 24-foot-high statue for regilding so that it could be placed in the company's new headquarters, the chairman was shocked to discover that the figure was anatomically correct. So he decreed that it also be gelded. The altered "Golden Boy" thus became a metaphor for AT&T's recent embattled history, and it serves as a cautionary symbol for all companies operating in today's brutal business environment, where perception can be as important as reality. While image consultants and executives work to gild a company's image, special interest groups and the media can geld a company with countless little cuts. The author, a former executive vice president of public relations for AT&T, provides an insider's view of some of the company's most painful public-relations scrapes. They include the collapse of two apparent CEO succession plans, AT&T's inability to meet heightened expectations after Mike Armstrong was appointed CEO, and the racially charged furor over a cartoon in an employee publication. The author offers four lessons: Don't become hypnotized by your own buzz; understand the way the business media think; address the needs of all your stakeholders; and be sensitive to the possible emotional resonance of what appear to be straightforward facts. To illustrate the final point, the author mentions AT&T's elimination of 40,000 jobs in 1996. Wall Street was impressed, but NBC's Tom Brokaw said the workforce reduction might signal "another long, anxious year for the American middle class." No rational argument from AT&T could overcome the layoffs' symbolic impact. Wounded but wiser after numerous public-relations battles, the company eventually learned to stop aggregating job-reduction information for the media.

Simulating environmental and psychological acoustic factors of the operating room.

PubMed

Bennett, Christopher L; Dudaryk, Roman; Ayers, Andrew L; McNeer, Richard R

2015-12-01

In this study, an operating room simulation environment was adapted to include quadraphonic speakers, which were used to recreate a composed clinical soundscape. To assess validity of the composed soundscape, several acoustic parameters of this simulated environment were acquired in the presence of alarms only, background noise only, or both. These parameters were also measured for comparison from size-matched operating rooms at Jackson Memorial Hospital. The parameters examined included sound level, reverberation time, and predictive metrics of speech intelligibility in quiet and noise. It was found that the sound levels and acoustic parameters were comparable between the simulated environment and the actual operating rooms. The impact of the background noise on the perception of medical alarms was then examined, and was found to have little impact on the audibility of the alarms. This study is a first in kind report of a comparison between the environmental and psychological acoustical parameters of a hospital simulation environment and actual operating rooms.

Uniaxial low cycle fatigue behavior for pre-corroded 16MND5 bainitic steel in simulated pressurized water reactor environment

NASA Astrophysics Data System (ADS)

Chen, Xu; Ren, Bin; Yu, Dunji; Xu, Bin; Zhang, Zhe; Chen, Gang

2018-06-01

The effects of uniaxial tension properties and low cycle fatigue behavior of 16MND5 bainitic steel cylinder pre-corroded in simulated pressurized water reactor (PWR) were investigated by fatigue at room temperature in air and immersion test system, scanning electron microscopy (SEM), energy disperse spectroscopy (EDS). The experimental results indicated that the corrosion fatigue lives of 16MND5 specimen were significantly affected by the strain amplitude and simulated PWR environments. The compositions of corrosion products were complexly formed in simulated PWR environments. The porous corrosion surface of pre-corroded materials tended to generate pits as a result of promoting contact area to the fresh metal, which promoted crack initiation. For original materials, the fatigue cracks initiated at inclusions imbedded in the micro-cracks. Moreover, the simulated PWR environments degraded the mechanical properties and low cycle fatigue behavior of 16MND5 specimens remarkably. Pre-corrosion of 16MND5 specimen mainly affected the plastic term of the Coffin-Manson equation.

The effects of simulated space environmental parameters on six commercially available composite materials

NASA Technical Reports Server (NTRS)

Funk, Joan G.; Sykes, George F., Jr.

1989-01-01

The effects of simulated space environmental parameters on microdamage induced by the environment in a series of commercially available graphite-fiber-reinforced composite materials were determined. Composites with both thermoset and thermoplastic resin systems were studied. Low-Earth-Orbit (LEO) exposures were simulated by thermal cycling; geosynchronous-orbit (GEO) exposures were simulated by electron irradiation plus thermal cycling. The thermal cycling temperature range was -250 F to either 200 F or 150 F. The upper limits of the thermal cycles were different to ensure that an individual composite material was not cycled above its glass transition temperature. Material response was characterized through assessment of the induced microcracking and its influence on mechanical property changes at both room temperature and -250 F. Microdamage was induced in both thermoset and thermoplastic advanced composite materials exposed to the simulated LEO environment. However, a 350 F cure single-phase toughened epoxy composite was not damaged during exposure to the LEO environment. The simuated GEO environment produced microdamage in all materials tested.

Physics-based statistical model and simulation method of RF propagation in urban environments

DOEpatents

Pao, Hsueh-Yuan; Dvorak, Steven L.

2010-09-14

A physics-based statistical model and simulation/modeling method and system of electromagnetic wave propagation (wireless communication) in urban environments. In particular, the model is a computationally efficient close-formed parametric model of RF propagation in an urban environment which is extracted from a physics-based statistical wireless channel simulation method and system. The simulation divides the complex urban environment into a network of interconnected urban canyon waveguides which can be analyzed individually; calculates spectral coefficients of modal fields in the waveguides excited by the propagation using a database of statistical impedance boundary conditions which incorporates the complexity of building walls in the propagation model; determines statistical parameters of the calculated modal fields; and determines a parametric propagation model based on the statistical parameters of the calculated modal fields from which predictions of communications capability may be made.

Development of Virtual Airspace Simulation Technology - Real-Time (VAST-RT) Capability 2 and Experimental Plans

NASA Technical Reports Server (NTRS)

Lehmer, R.; Ingram, C.; Jovic, S.; Alderete, J.; Brown, D.; Carpenter, D.; LaForce, S.; Panda, R.; Walker, J.; Chaplin, P.;

Simulation experience enhances physical therapist student confidence in managing a patient in the critical care environment.

PubMed

Ohtake, Patricia J; Lazarus, Marcilene; Schillo, Rebecca; Rosen, Michael

2013-02-01

Rehabilitation of patients in critical care environments improves functional outcomes. This finding has led to increased implementation of intensive care unit (ICU) rehabilitation programs, including early mobility, and an associated increased demand for physical therapists practicing in ICUs. Unfortunately, many physical therapists report being inadequately prepared to work in this high-risk environment. Simulation provides focused, deliberate practice in safe, controlled learning environments and may be a method to initiate academic preparation of physical therapists for ICU practice. The purpose of this study was to examine the effect of participation in simulation-based management of a patient with critical illness in an ICU setting on levels of confidence and satisfaction in physical therapist students. A one-group, pretest-posttest, quasi-experimental design was used. Physical therapist students (N=43) participated in a critical care simulation experience requiring technical (assessing bed mobility and pulmonary status), behavioral (patient and interprofessional communication), and cognitive (recognizing a patient status change and initiating appropriate responses) skill performance. Student confidence and satisfaction were surveyed before and after the simulation experience. Students' confidence in their technical, behavioral, and cognitive skill performance increased from "somewhat confident" to "confident" following the critical care simulation experience. Student satisfaction was highly positive, with strong agreement the simulation experience was valuable, reinforced course content, and was a useful educational tool. Limitations of the study were the small sample from one university and a control group was not included. Incorporating a simulated, interprofessional critical care experience into a required clinical course improved physical therapist student confidence in technical, behavioral, and cognitive performance measures and was associated with high student satisfaction. Using simulation, students were introduced to the critical care environment, which may increase interest in working in this practice area.

A Java-Enabled Interactive Graphical Gas Turbine Propulsion System Simulator

NASA Technical Reports Server (NTRS)

Reed, John A.; Afjeh, Abdollah A.

1997-01-01

This paper describes a gas turbine simulation system which utilizes the newly developed Java language environment software system. The system provides an interactive graphical environment which allows the quick and efficient construction and analysis of arbitrary gas turbine propulsion systems. The simulation system couples a graphical user interface, developed using the Java Abstract Window Toolkit, and a transient, space- averaged, aero-thermodynamic gas turbine analysis method, both entirely coded in the Java language. The combined package provides analytical, graphical and data management tools which allow the user to construct and control engine simulations by manipulating graphical objects on the computer display screen. Distributed simulations, including parallel processing and distributed database access across the Internet and World-Wide Web (WWW), are made possible through services provided by the Java environment.

Coupling indoor airflow, HVAC, control and building envelope heat transfer in the Modelica Buildings library

DOE PAGES

Zuo, Wangda; Wetter, Michael; Tian, Wei; ...

2015-07-13

Here, this paper describes a coupled dynamic simulation of an indoor environment with heating, ventilation, and air conditioning (HVAC) systems, controls and building envelope heat transfer. The coupled simulation can be used for the design and control of ventilation systems with stratified air distributions. Those systems are commonly used to reduce building energy consumption while improving the indoor environment quality. The indoor environment was simulated using the fast fluid dynamics (FFD) simulation programme. The building fabric heat transfer, HVAC and control system were modelled using the Modelica Buildings library. After presenting the concept, the mathematical algorithm and the implementation ofmore » the coupled simulation were introduced. The coupled FFD–Modelica simulation was then evaluated using three examples of room ventilation with complex flow distributions with and without feedback control. Lastly, further research and development needs were also discussed.« less

Coupling indoor airflow, HVAC, control and building envelope heat transfer in the Modelica Buildings library

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zuo, Wangda; Wetter, Michael; Tian, Wei

Here, this paper describes a coupled dynamic simulation of an indoor environment with heating, ventilation, and air conditioning (HVAC) systems, controls and building envelope heat transfer. The coupled simulation can be used for the design and control of ventilation systems with stratified air distributions. Those systems are commonly used to reduce building energy consumption while improving the indoor environment quality. The indoor environment was simulated using the fast fluid dynamics (FFD) simulation programme. The building fabric heat transfer, HVAC and control system were modelled using the Modelica Buildings library. After presenting the concept, the mathematical algorithm and the implementation ofmore » the coupled simulation were introduced. The coupled FFD–Modelica simulation was then evaluated using three examples of room ventilation with complex flow distributions with and without feedback control. Lastly, further research and development needs were also discussed.« less

Rover Attitude and Pointing System Simulation Testbed

NASA Technical Reports Server (NTRS)

Vanelli, Charles A.; Grinblat, Jonathan F.; Sirlin, Samuel W.; Pfister, Sam

2009-01-01

The MER (Mars Exploration Rover) Attitude and Pointing System Simulation Testbed Environment (RAPSSTER) provides a simulation platform used for the development and test of GNC (guidance, navigation, and control) flight algorithm designs for the Mars rovers, which was specifically tailored to the MERs, but has since been used in the development of rover algorithms for the Mars Science Laboratory (MSL) as well. The software provides an integrated simulation and software testbed environment for the development of Mars rover attitude and pointing flight software. It provides an environment that is able to run the MER GNC flight software directly (as opposed to running an algorithmic model of the MER GNC flight code). This improves simulation fidelity and confidence in the results. Further more, the simulation environment allows the user to single step through its execution, pausing, and restarting at will. The system also provides for the introduction of simulated faults specific to Mars rover environments that cannot be replicated in other testbed platforms, to stress test the GNC flight algorithms under examination. The software provides facilities to do these stress tests in ways that cannot be done in the real-time flight system testbeds, such as time-jumping (both forwards and backwards), and introduction of simulated actuator faults that would be difficult, expensive, and/or destructive to implement in the real-time testbeds. Actual flight-quality codes can be incorporated back into the development-test suite of GNC developers, closing the loop between the GNC developers and the flight software developers. The software provides fully automated scripting, allowing multiple tests to be run with varying parameters, without human supervision.

Assessment of Capabilities for First-Principles Simulation of Spacecraft Electric Propulsion Systems and Plasma Spacecraft Environment

DTIC Science & Technology

2016-04-29

Simulation of Spacecraft Electric Propulsion Systems and Plasma Spacecraft Environment 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...Assessment of Capabilities for First‐ Principles Simulation of Spacecraft Electric  Propulsion   Systems and Plasma Spacecraft Environment” Team leader(s

Computer Support of Operator Training: Constructing and Testing a Prototype of a CAL (Computer Aided Learning) Supported Simulation Environment.

ERIC Educational Resources Information Center

Zillesen, P. G. van Schaick; And Others

Instructional feedback given to the learners during computer simulation sessions may be greatly improved by integrating educational computer simulation programs with hypermedia-based computer-assisted learning (CAL) materials. A prototype of a learning environment of this type called BRINE PURIFICATION was developed for use in corporate training…

Enhancing Computer Science Education with a Wireless Intelligent Simulation Environment

ERIC Educational Resources Information Center

Cook, Diane J.; Huber, Manfred; Yerraballi, Ramesh; Holder, Lawrence B.

2004-01-01

The goal of this project is to develop a unique simulation environment that can be used to increase students' interest and expertise in Computer Science curriculum. Hands-on experience with physical or simulated equipment is an essential ingredient for learning, but many approaches to training develop a separate piece of equipment or software for…

Using Blackboard Wiki Pages as a Shared Space for Simulating the Professional Translation Work Environment

ERIC Educational Resources Information Center

Vine, Juliet

2015-01-01

The Work-Integrated Simulation for Translators module is part of a three year undergraduate degree in translation. The semester long module aims to simulate several aspects of the translation process using the Blackboard virtual learning environment's Wikis as the interface for completing translation tasks. For each translation task, one of the…

Structure and properties of Hardox 450 steel with arc welded coatings

NASA Astrophysics Data System (ADS)

Ivanov, Yu. F.; Konovalov, S. V.; Kormyshev, V. E.; Gromov, V. E.; Teresov, A. D.; Semina, O. A.

2017-12-01

The paper reports on a study of the surface structure, phase composition, and microhardness of Hardox 450 steel with coatings deposited by arc welding of powder wires differing in chemical composition. The study shows that to a depth of 6-8 mm, the microhardness of the thus formed coatings is more than two times the microhardness of the base metal and that their higher mechanical properties are provided by martensite structure containing Nb2C and NbC carbides and Fe2B borides as eutectic lamellae with a transverse size of 30-70 nm; their volume reveals a net-like dislocation substructure with a scalar dislocation density of 1011 cm-2. The highest surface hardness is found for the steel coated with boron-containing wire material. Some ideas are suggested on possible mechanisms and temperature for the formation of Nb and B carbides during the process.

Chronicler's Induction Ceremony

NASA Image and Video Library

2017-05-05

Current and retired NASA Public Affairs team members and space journalists gather in the NASA News Center at Kennedy Space Center in Florida for a ceremony in which six new honorees were added to the "Chroniclers" roll of honor. From left to right are Jay Barbree, NBC News; Al Feinberg, NASA Public Affairs; Marcia Dunn, Associated Press; Hugh Harris, NASA Public Affairs; Warren Leary, The New York Times; Phillip Sandlin, Associated Press photographer; Bob Murray, WDBO-TV, RCA and United Space Alliance; Bill Harwood, CBS News, there on behalf of the late Bruce Hall, CBS News; Bill Johnson, NASA Public Affairs; Emery McGough, son of the late Scott Harris, WESH, WKMG and Central Florida News 13; and Center Director Bob Cabana. Hall, Harris, Johnson, Leary, Murray and Sandlin are the 2017 Chroniclers. The program recognizes retirees of the news and communications business who helped spread news of American space exploration from Kennedy Space Center for ten years or more.

Effect of prior deformation on microstructural development and Laves phase precipitation in high-chromium stainless steel.

PubMed

Hsiao, Z-W; Chen, D; Kuo, J-C; Lin, D-Y

2017-04-01

This study investigated the influence of deformation on precipitation behaviour and microstructure change during annealing. Here, the prior deformation of high-chromium stainless steel was tensile deformation of 3%, 6% and 10%, and the specimens were then annealed at 700˚C for 10 h. The specimens were subsequently analyzed using backscattered electron image and electron backscattering diffraction measurements with SEM. Compared with the deformation microstructure, the grains revealed no preferred orientation. The precipitates of TiN and NbC were formed homogenously in the grain interior and at grain boundaries after annealing. Fine Laves phase precipitates were observed in grains and along subgrain boundaries as the deformation increased. Furthermore, the volume fraction of Laves phase increased, but the average particle diameter of precipitate was reduced as the deformation increased. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

Neural stem cells induce the formation of their physical niche during organogenesis

PubMed Central

Riebesehl, Bea F; Ambrosio, Elizabeth M; Stolper, Julian S; Lischik, Colin Q; Dross, Nicolas

2017-01-01

Most organs rely on stem cells to maintain homeostasis during post-embryonic life. Typically, stem cells of independent lineages work coordinately within mature organs to ensure proper ratios of cell types. Little is known, however, on how these different stem cells locate to forming organs during development. Here we show that neuromasts of the posterior lateral line in medaka are composed of two independent life-long lineages with different embryonic origins. Clonal analysis and 4D imaging revealed a hierarchical organisation with instructing and responding roles: an inner, neural lineage induces the formation of an outer, border cell lineage (nBC) from the skin epithelium. Our results demonstrate that the neural lineage is necessary and sufficient to generate nBCs highlighting self-organisation principles at the level of the entire embryo. We hypothesise that induction of surrounding tissues plays a major role during the establishment of vertebrate stem cell niches. PMID:28950935

An Individual Finger Gesture Recognition System Based on Motion-Intent Analysis Using Mechanomyogram Signal

PubMed Central

Ding, Huijun; He, Qing; Zhou, Yongjin; Dan, Guo; Cui, Song

2017-01-01

Motion-intent-based finger gesture recognition systems are crucial for many applications such as prosthesis control, sign language recognition, wearable rehabilitation system, and human–computer interaction. In this article, a motion-intent-based finger gesture recognition system is designed to correctly identify the tapping of every finger for the first time. Two auto-event annotation algorithms are firstly applied and evaluated for detecting the finger tapping frame. Based on the truncated signals, the Wavelet packet transform (WPT) coefficients are calculated and compressed as the features, followed by a feature selection method that is able to improve the performance by optimizing the feature set. Finally, three popular classifiers including naive Bayes (NBC), K-nearest neighbor (KNN), and support vector machine (SVM) are applied and evaluated. The recognition accuracy can be achieved up to 94%. The design and the architecture of the system are presented with full system characterization results. PMID:29167655

KSC-2011-3325

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- NBC reporter Jay Barbree introduces Alice Wackermann, Julie Jenkins and Laura Churchley, daughters of astronaut Alan Shepard, to the audience at a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

KSC-2011-3318

NASA Image and Video Library

2011-05-05

CAPE CANAVERAL, Fla. -- From left, NBC reporter Jay Barbree and Alice Wackermann, Julie Jenkins (at microphone) and Laura Churchley, daughters of astronaut Alan Shepard, participate in a celebration at Complex 5/6 on Cape Canaveral Air Force Station in Florida. The celebration was held at the launch site of the first U.S. manned spaceflight May 5, 1961, to mark the 50th anniversary of the flight. Fifty years ago, astronaut Alan Shepard lifted off inside the Mercury capsule, "Freedom 7," atop an 82-foot-tall Mercury-Redstone rocket at 9:34 a.m. EST, sending him on a remarkably successful, 15-minute suborbital flight. The event was attended by more than 200 workers from the original Mercury program and included a re-creation of Shepard's flight and recovery, as well as a tribute to his contributions as a moonwalker on the Apollo 14 lunar mission. For more information, visit www.nasa.gov/topics/history/milestones/index.html. Photo credit: NASA/Kim Shiflett

Response of terrestrial microorganisms to a simulated Martian environment.

PubMed Central

Foster, T L; Winans, L; Casey, R C; Kirschner, L E

1978-01-01

Soil samples from Cape Canaveral were subjected to a simulated Martian environment and assayed periodically over 45 days to determine the effect of various environmental parameters on bacterial populations. The simulated environment was based on the most recent available data, prior to the Viking spacecraft, describing Martian conditions and consisted of a pressure of 7 millibars, an atmosphere of 99.9% CO2 and 0.1% O2, a freeze-thaw cycle of -65 degrees C for 16 h and 24 degrees C for 8 h, and variable moisture and nutrients. Reduced pressure had a significant effect, reducing growth under these conditions. Slight variations in gaseous composition of the simulated atmosphere had negligible effect on growth. The freeze-thaw cycle did not inhibit growth but did result in a slower rate of decline after growth had occurred. Dry samples exhibited no change during the 45-day experiment, indicating that the simulated Martian environment was not toxic to bacterial populations. Psychotrophic organisms responded more favorably to this environment than mesophiles, although both types exhibited increases of approximately 3 logs in 7 to 14 days when moisture and nutrients were available. PMID:646358

Development of a virtual flight simulator.

PubMed

Kuntz Rangel, Rodrigo; Guimarães, Lamartine N F; de Assis Correa, Francisco

2002-10-01

We present the development of a flight simulator that allows the user to interact in a created environment by means of virtual reality devices. This environment simulates the sight of a pilot in an airplane cockpit. The environment is projected in a helmet visor and allows the pilot to see inside as well as outside the cockpit. The movement of the airplane is independent of the movement of the pilot's head, which means that the airplane might travel in one direction while the pilot is looking at a 30 degrees angle with respect to the traveled direction. In this environment, the pilot will be able to take off, fly, and land the airplane. So far, the objects in the environment are geometrical figures. This is an ongoing project, and only partial results are available now.

The Safety Analysis of Shipborne Ammunition in Fire Environment

NASA Astrophysics Data System (ADS)

Ren, Junpeng; Wang, Xudong; Yue, Pengfei

2017-12-01

The safety of Ammunition has always been the focus of national military science and technology issues. And fire is one of the major safety threats to the ship’s ammunition storage environment, In this paper, Mk-82 shipborne aviation bomb has been taken as the study object, simulated the whole process of fire by using the FDS (Fire Detection System) software. According to the simulation results of FDS, ANSYS software was used to simulate the temperature field of Mk-82 carrier-based aviation bomb under fire environment, and the safety of aviation bomb in fire environment was analyzed. The result shows that the aviation bombs under the fire environment can occur the combustion or explosion after 70s constant cook-off, and it was a huge threat to the ship security.

Validated robotic laparoscopic surgical training in a virtual-reality environment.

PubMed

Katsavelis, Dimitrios; Siu, Ka-Chun; Brown-Clerk, Bernadette; Lee, Irene H; Lee, Yong Kwon; Oleynikov, Dmitry; Stergiou, Nick

2009-01-01

A robotic virtual-reality (VR) simulator has been developed to improve robot-assisted training for laparoscopic surgery and to enhance surgical performance in laparoscopic skills. The simulated VR training environment provides an effective approach to evaluate and improve surgical performance. This study presents our findings of the VR training environment for robotic laparoscopy. Eight volunteers performed two inanimate tasks in both the VR and the actual training environment. The tasks were bimanual carrying (BC) and needle passing (NP). For the BC task, the volunteers simultaneously transferred two plastic pieces in opposite directions five times consecutively. The same volunteers passed a surgical needle through six pairs of holes in the NP task. Both tasks require significant bimanual coordination that mimics actual laparoscopic skills. Data analysis included time to task completion, speed and distance traveled of the instrument tip, as well as range of motion of the subject's wrist and elbow of the right arm. Electromyography of the right wrist flexor and extensor were also analyzed. Paired t-tests and Pearson's r were used to explore the differences and correlations between the two environments. There were no significant differences between the actual and the simulated VR environment with respect to the BC task, while there were significant differences in almost all dependent parameters for the NP task. Moderate to high correlations for most dependent parameters were revealed for both tasks. Our data shows that the VR environment adequately simulated the BC task. The significant differences found for the NP task may be attributed to an oversimplification in the VR environment. However, they do point to the need for improvements in the complexity of our VR simulation. Further research work is needed to develop effective and reliable VR environments for robotic laparoscopic training.

Self-adaptive Fault-Tolerance of HLA-Based Simulations in the Grid Environment

NASA Astrophysics Data System (ADS)

Huang, Jijie; Chai, Xudong; Zhang, Lin; Li, Bo Hu

The objects of a HLA-based simulation can access model services to update their attributes. However, the grid server may be overloaded and refuse the model service to handle objects accesses. Because these objects have been accessed this model service during last simulation loop and their medium state are stored in this server, this may terminate the simulation. A fault-tolerance mechanism must be introduced into simulations. But the traditional fault-tolerance methods cannot meet the above needs because the transmission latency between a federate and the RTI in grid environment varies from several hundred milliseconds to several seconds. By adding model service URLs to the OMT and expanding the HLA services and model services with some interfaces, this paper proposes a self-adaptive fault-tolerance mechanism of simulations according to the characteristics of federates accessing model services. Benchmark experiments indicate that the expanded HLA/RTI can make simulations self-adaptively run in the grid environment.

Simulation and animation of sensor-driven robots.

PubMed

Chen, C; Trivedi, M M; Bidlack, C R

1994-10-01

Most simulation and animation systems utilized in robotics are concerned with simulation of the robot and its environment without simulation of sensors. These systems have difficulty in handling robots that utilize sensory feedback in their operation. In this paper, a new design of an environment for simulation, animation, and visualization of sensor-driven robots is presented. As sensor technology advances, increasing numbers of robots are equipped with various types of sophisticated sensors. The main goal of creating the visualization environment is to aid the automatic robot programming and off-line programming capabilities of sensor-driven robots. The software system will help the users visualize the motion and reaction of the sensor-driven robot under their control program. Therefore, the efficiency of the software development is increased, the reliability of the software and the operation safety of the robot are ensured, and the cost of new software development is reduced. Conventional computer-graphics-based robot simulation and animation software packages lack of capabilities for robot sensing simulation. This paper describes a system designed to overcome this deficiency.

The Influences of the 2D Image-Based Augmented Reality and Virtual Reality on Student Learning

ERIC Educational Resources Information Center

Liou, Hsin-Hun; Yang, Stephen J. H.; Chen, Sherry Y.; Tarng, Wernhuar

2017-01-01

Virtual reality (VR) learning environments can provide students with concepts of the simulated phenomena, but users are not allowed to interact with real elements. Conversely, augmented reality (AR) learning environments blend real-world environments so AR could enhance the effects of computer simulation and promote students' realistic experience.…

A Model Supported Interactive Virtual Environment for Natural Resource Sharing in Environmental Education

ERIC Educational Resources Information Center

Barbalios, N.; Ioannidou, I.; Tzionas, P.; Paraskeuopoulos, S.

2013-01-01

This paper introduces a realistic 3D model supported virtual environment for environmental education, that highlights the importance of water resource sharing by focusing on the tragedy of the commons dilemma. The proposed virtual environment entails simulations that are controlled by a multi-agent simulation model of a real ecosystem consisting…

Flexible Simulation E-Learning Environment for Studying Digital Circuits and Possibilities for It Deployment as Semantic Web Service

ERIC Educational Resources Information Center

Radoyska, P.; Ivanova, T.; Spasova, N.

2011-01-01

In this article we present a partially realized project for building a distributed learning environment for studying digital circuits Test and Diagnostics at TU-Sofia. We describe the main requirements for this environment, substantiate the developer platform choice, and present our simulation and circuit parameter calculation tools.…

pV3-Gold Visualization Environment for Computer Simulations

NASA Technical Reports Server (NTRS)

Babrauckas, Theresa L.

1997-01-01

A new visualization environment, pV3-Gold, can be used during and after a computer simulation to extract and visualize the physical features in the results. This environment, which is an extension of the pV3 visualization environment developed at the Massachusetts Institute of Technology with guidance and support by researchers at the NASA Lewis Research Center, features many tools that allow users to display data in various ways.

Simulation of the dynamic environment for missile component testing: Demonstration

NASA Technical Reports Server (NTRS)

Chang, Kurng Y.

1989-01-01

The problems in defining a realistic test requirement for missile and space vehicle components can be classified into two categories: (1) definition of the test environment representing the expected service condition, and (2) simulation of the desired environment in the test laboratory. Recently, a new three-dimensional (3-D) test facility was completed at the U.S. Army Harry Diamond Laboratory (HDL) to simulate triaxial vibration input to a test specimen. The vibration test system is designed to support multi-axial vibration tests over the frequency range of 5 to 2000 Hertz. The availability of this 3-D test system motivates the development of new methodologies addressing environmental definition and simulation.

Simulation environment and graphical visualization environment: a COPD use-case.

PubMed

Huertas-Migueláñez, Mercedes; Mora, Daniel; Cano, Isaac; Maier, Dieter; Gomez-Cabrero, David; Lluch-Ariet, Magí; Miralles, Felip

2014-11-28

Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which in turn simplify the communication among models. Nevertheless, not all of these tools are able to run models written in different programming languages. In addition, interoperability between such models remains an unresolved issue. In this paper we present a simulation environment that allows, first, the execution of models developed in different programming languages and second the communication of parameters to interconnect these models. This simulation environment, developed within the Synergy-COPD project, aims at helping and supporting bio-researchers and medical students understand the internal mechanisms of the human body through the use of physiological models. This tool is composed of a graphical visualization environment, which is a web interface through which the user can interact with the models, and a simulation workflow management system composed of a control module and a data warehouse manager. The control module monitors the correct functioning of the whole system. The data warehouse manager is responsible for managing the stored information and supporting its flow among the different modules. It has been proved that the simulation environment presented here allows the user to research and study the internal mechanisms of the human physiology by the use of models via a graphical visualization environment. A new tool for bio-researchers is ready for deployment in various use cases scenarios.

VHDL simulation with access to transistor models

NASA Technical Reports Server (NTRS)

Gibson, J.

1991-01-01

Hardware description languages such as VHDL have evolved to aid in the design of systems with large numbers of elements and a wide range of electronic and logical abstractions. For high performance circuits, behavioral models may not be able to efficiently include enough detail to give designers confidence in a simulation's accuracy. One option is to provide a link between the VHDL environment and a transistor level simulation environment. The coupling of the Vantage Analysis Systems VHDL simulator and the NOVA simulator provides the combination of VHDL modeling and transistor modeling.

Environments for online maritime simulators with cloud computing capabilities

NASA Astrophysics Data System (ADS)

Raicu, Gabriel; Raicu, Alexandra

2016-12-01

This paper presents the cloud computing environments, network principles and methods for graphical development in realistic naval simulation, naval robotics and virtual interactions. The aim of this approach is to achieve a good simulation quality in large networked environments using open source solutions designed for educational purposes. Realistic rendering of maritime environments requires near real-time frameworks with enhanced computing capabilities during distance interactions. E-Navigation concepts coupled with the last achievements in virtual and augmented reality will enhance the overall experience leading to new developments and innovations. We have to deal with a multiprocessing situation using advanced technologies and distributed applications using remote ship scenario and automation of ship operations.

Software Maintenance of the Subway Environment Simulation Computer Program

DOT National Transportation Integrated Search

1980-12-01

This document summarizes the software maintenance activities performed to support the Subway Environment Simulation (SES) Computer Program. The SES computer program is a design-oriented analytic tool developed during a recent five-year research proje...

Effect of motion frequency spectrum on subjective comfort response. [modeling passenger reactions to commercial aircraft flights

NASA Technical Reports Server (NTRS)

Jacobson, I. D.; Schoultz, M. B.; Blake, J. C.

1973-01-01

In order to model passenger reaction to present and future aircraft environments, it is necessary to obtain data in several ways. First, of course, is the gathering of environmental and passenger reaction data on commercial aircraft flights. In addition, detailed analyses of particular aspects of human reaction to the environment are best studied in a controllable experimental situation. Thus the use of simulators, both flight and ground based, is suggested. It is shown that there is a reasonably high probability that the low frequency end of the spectrum will not be necessary for simulation purposes. That is, the fidelity of any simulation which omits the very low frequency content will not yield results which differ significantly from the real environment. In addition, there does not appear to be significant differences between the responses obtained in the airborne simulator environment versus those obtained on commercial flights.

Simulation of Smart Home Activity Datasets

PubMed Central

Synnott, Jonathan; Nugent, Chris; Jeffers, Paul

2015-01-01

A globally ageing population is resulting in an increased prevalence of chronic conditions which affect older adults. Such conditions require long-term care and management to maximize quality of life, placing an increasing strain on healthcare resources. Intelligent environments such as smart homes facilitate long-term monitoring of activities in the home through the use of sensor technology. Access to sensor datasets is necessary for the development of novel activity monitoring and recognition approaches. Access to such datasets is limited due to issues such as sensor cost, availability and deployment time. The use of simulated environments and sensors may address these issues and facilitate the generation of comprehensive datasets. This paper provides a review of existing approaches for the generation of simulated smart home activity datasets, including model-based approaches and interactive approaches which implement virtual sensors, environments and avatars. The paper also provides recommendation for future work in intelligent environment simulation. PMID:26087371

Variation of linear and circular polarization persistence for changing field of view and collection area in a forward scattering environment

NASA Astrophysics Data System (ADS)

van der Laan, John D.; Wright, Jeremy B.; Scrymgeour, David A.; Kemme, Shanalyn A.; Dereniak, Eustace L.

2016-05-01

We present experimental and simulation results for a laboratory-based forward-scattering environment, where 1 μm diameter polystyrene spheres are suspended in water to model the optical scattering properties of fog. Circular polarization maintains its degree of polarization better than linear polarization as the optical thickness of the scattering environment increases. Both simulation and experiment quantify circular polarization's superior persistence, compared to that of linear polarization, and show that it is much less affected by variations in the field of view and collection area of the optical system. Our experimental environment's lateral extent was physically finite, causing a significant difference between measured and simulated degree of polarization values for incident linearly polarized light, but not for circularly polarized light. Through simulation we demonstrate that circular polarization is less susceptible to the finite environmental extent as well as the collection optic's limiting configuration.

Simulation of Smart Home Activity Datasets.

PubMed

Synnott, Jonathan; Nugent, Chris; Jeffers, Paul

2015-06-16

A globally ageing population is resulting in an increased prevalence of chronic conditions which affect older adults. Such conditions require long-term care and management to maximize quality of life, placing an increasing strain on healthcare resources. Intelligent environments such as smart homes facilitate long-term monitoring of activities in the home through the use of sensor technology. Access to sensor datasets is necessary for the development of novel activity monitoring and recognition approaches. Access to such datasets is limited due to issues such as sensor cost, availability and deployment time. The use of simulated environments and sensors may address these issues and facilitate the generation of comprehensive datasets. This paper provides a review of existing approaches for the generation of simulated smart home activity datasets, including model-based approaches and interactive approaches which implement virtual sensors, environments and avatars. The paper also provides recommendation for future work in intelligent environment simulation.

MACHETE: Environment for Space Networking Evaluation

NASA Technical Reports Server (NTRS)

Jennings, Esther H.; Segui, John S.; Woo, Simon

2010-01-01

Space Exploration missions requires the design and implementation of space networking that differs from terrestrial networks. In a space networking architecture, interplanetary communication protocols need to be designed, validated and evaluated carefully to support different mission requirements. As actual systems are expensive to build, it is essential to have a low cost method to validate and verify mission/system designs and operations. This can be accomplished through simulation. Simulation can aid design decisions where alternative solutions are being considered, support trade-studies and enable fast study of what-if scenarios. It can be used to identify risks, verify system performance against requirements, and as an initial test environment as one moves towards emulation and actual hardware implementation of the systems. We describe the development of Multi-mission Advanced Communications Hybrid Environment for Test and Evaluation (MACHETE) and its use cases in supporting architecture trade studies, protocol performance and its role in hybrid simulation/emulation. The MACHETE environment contains various tools and interfaces such that users may select the set of tools tailored for the specific simulation end goal. The use cases illustrate tool combinations for simulating space networking in different mission scenarios. This simulation environment is useful in supporting space networking design for planned and future missions as well as evaluating performance of existing networks where non-determinism exist in data traffic and/or link conditions.

Learner-Centered Instruction (LCI): Volume IV, The Simulated Maintenance Task Environment (SMTE): A Job Specific Simulator.

ERIC Educational Resources Information Center

Rifkin, Kenneth I.; And Others

The purpose of the simulated maintenance task environment is to provide a means for training and job performance testing of the flight line weapon control systems mechanic/technician for the F-111A aircraft. It provides practice in flight line equipment checkout, troubleshooting, and removal and replacement of line replaceable units in the…

Experiences with a Simulated Learning Environment--The SimuScape©: Virtual Environments in Medical Education

ERIC Educational Resources Information Center

Thies, Anna-Lena; Weissenstein, Anne; Haulsen, Ivo; Marschall, Bernhard; Friederichs, Hendrik

2014-01-01

Simulation as a tool for medical education has gained considerable importance in the past years. Various studies have shown that the mastering of basic skills happens best if taught in a realistic and workplace-based context. It is necessary that simulation itself takes place in the realistic background of a genuine clinical or in an accordingly…

The Effects of an Energy-Environment Simulator Upon Selected Energy-Related Attitudes of Science Students and In-Service Teachers.

ERIC Educational Resources Information Center

Dunlop, David L.

This document is the outcome of a study designed to investigate the energy-related attitudes of several different groups of science students and science teachers both before and after working with an energy-environment simulator for approximately an hour. During the interaction with the simulator, the participants decided upon the variables they…

Fire training in a virtual-reality environment

NASA Astrophysics Data System (ADS)

Freund, Eckhard; Rossmann, Jurgen; Bucken, Arno

2005-03-01

Although fire is very common in our daily environment - as a source of energy at home or as a tool in industry - most people cannot estimate the danger of a conflagration. Therefore it is important to train people in combating fire. Beneath training with propane simulators or real fires and real extinguishers, fire training can be performed in virtual reality, which means a pollution-free and fast way of training. In this paper we describe how to enhance a virtual-reality environment with a real-time fire simulation and visualisation in order to establish a realistic emergency-training system. The presented approach supports extinguishing of the virtual fire including recordable performance data as needed in teletraining environments. We will show how to get realistic impressions of fire using advanced particle-simulation and how to use the advantages of particles to trigger states in a modified cellular automata used for the simulation of fire-behaviour. Using particle systems that interact with cellular automata it is possible to simulate a developing, spreading fire and its reaction on different extinguishing agents like water, CO2 or oxygen. The methods proposed in this paper have been implemented and successfully tested on Cosimir, a commercial robot-and VR-simulation-system.

Design Patterns for Learning and Assessment: Facilitating the Introduction of a Complex Simulation-Based Learning Environment into a Community of Instructors

NASA Astrophysics Data System (ADS)

Frezzo, Dennis C.; Behrens, John T.; Mislevy, Robert J.

2010-04-01

Simulation environments make it possible for science and engineering students to learn to interact with complex systems. Putting these capabilities to effective use for learning, and assessing learning, requires more than a simulation environment alone. It requires a conceptual framework for the knowledge, skills, and ways of thinking that are meant to be developed, in order to design activities that target these capabilities. The challenges of using simulation environments effectively are especially daunting in dispersed social systems. This article describes how these challenges were addressed in the context of the Cisco Networking Academies with a simulation tool for computer networks called Packet Tracer. The focus is on a conceptual support framework for instructors in over 9,000 institutions around the world for using Packet Tracer in instruction and assessment, by learning to create problem-solving scenarios that are at once tuned to the local needs of their students and consistent with the epistemic frame of "thinking like a network engineer." We describe a layered framework of tools and interfaces above the network simulator that supports the use of Packet Tracer in the distributed community of instructors and students.

Simulation on the internal structure of three-dimensional proximal tibia under different mechanical environments.

PubMed

Fang, Juan; Gong, He; Kong, Lingyan; Zhu, Dong

2013-12-20

Bone can adjust its morphological structure to adapt to the changes of mechanical environment, i.e. the bone structure change is related to mechanical loading. This implies that osteoarthritis may be closely associated with knee joint deformity. The purposes of this paper were to simulate the internal bone mineral density (BMD) change in three-dimensional (3D) proximal tibia under different mechanical environments, as well as to explore the relationship between mechanical environment and bone morphological abnormity. The right proximal tibia was scanned with CT to reconstruct a 3D proximal tibia model in MIMICS, then it was imported to finite element software ANSYS to establish 3D finite element model. The internal structure of 3D proximal tibia of young normal people was simulated using quantitative bone remodeling theory in combination with finite element method, then based on the changing pattern of joint contact force on the tibial plateau in valgus knees, the mechanical loading was changed, and the simulated normal tibia structure was used as initial structure to simulate the internal structure of 3D proximal tibia for old people with 6° valgus deformity. Four regions of interest (ROIs) were selected in the proximal tibia to quantitatively analyze BMD and compare with the clinical measurements. The simulation results showed that the BMD distribution in 3D proximal tibia was consistent with clinical measurements in normal knees and that in valgus knees was consistent with the measurement of patients with osteoarthritis in clinics. It is shown that the change of mechanical environment is the main cause for the change of subchondral bone structure, and being under abnormal mechanical environment for a long time may lead to osteoarthritis. Besides, the simulation method adopted in this paper can more accurately simulate the internal structure of 3D proximal tibia under different mechanical environments. It helps to better understand the mechanism of osteoarthritis and provides theoretical basis and computational method for the prevention and treatment of osteoarthritis. It can also serve as basis for further study on periprosthetic BMD changes after total knee arthroplasty, and provide a theoretical basis for optimization design of prosthesis.

ISO WD 1856. Guideline for radiation exposure of nonmetallic materials. Present status

NASA Astrophysics Data System (ADS)

Briskman, B. A.

In the framework of the International Organization for Standardization (ISO) activity we started development of international standard series for space environment simulation at on-ground tests of materials. The proposal was submitted to ISO Technical Committee 20 (Aircraft and Space Vehicles), Subcommittee 14 (Space Systems and Operations) and was approved as Working Draft 15856 at the Los-Angeles meeting (1997). A draft of the first international standard "Space Environment Simulation for Radiation Tests of Materials" (1st version) was presented at the 7th International Symposium on Materials in Space Environment (Briskman et al, 1997). The 2nd version of the standard was limited to nonmetallic materials and presented at the 20th Space Simulation Conference (Briskman and Borson, 1998). It covers the testing of nonmetallic materials embracing also polymer composite materials including metal components (metal matrix composites) to simulated space radiation. The standard does not cover semiconductor materials. The types of simulated radiation include charged particles (electrons and protons), solar ultraviolet radiation, and soft X-radiation of solar flares. Synergistic interactions of the radiation environment are covered only for these natural and some induced environmental effects. This standard outlines the recommended methodology and practices for the simulation of space radiation on materials. Simulation methods are used to reproduce the effects of the space radiation environment on materials that are located on surfaces of space vehicles and behind shielding. It was discovered that the problem of radiation environment simulation is very complex and the approaches of different specialists and countries to the problem are sometimes quite opposite. To the present moment we developed seven versions of the standard. The last version is a compromise between these approaches. It was approved at the last ISO TC20/SC14/WG4 meeting in Houston, October 2002. At a splinter meeting of Int. Conference on Materials in a Space Environment, Noordwijk, Netherlands, ESA, June 2003, the experts from ESA, USA, France, Russia and Japan discussed the last version of the draft and approved it with a number of notes. A revised version of the standard will be presented this May at ISO TC20/SC14 meeting in Russia.

Simulation on the internal structure of three-dimensional proximal tibia under different mechanical environments

PubMed Central

2013-01-01

Background Bone can adjust its morphological structure to adapt to the changes of mechanical environment, i.e. the bone structure change is related to mechanical loading. This implies that osteoarthritis may be closely associated with knee joint deformity. The purposes of this paper were to simulate the internal bone mineral density (BMD) change in three-dimensional (3D) proximal tibia under different mechanical environments, as well as to explore the relationship between mechanical environment and bone morphological abnormity. Methods The right proximal tibia was scanned with CT to reconstruct a 3D proximal tibia model in MIMICS, then it was imported to finite element software ANSYS to establish 3D finite element model. The internal structure of 3D proximal tibia of young normal people was simulated using quantitative bone remodeling theory in combination with finite element method, then based on the changing pattern of joint contact force on the tibial plateau in valgus knees, the mechanical loading was changed, and the simulated normal tibia structure was used as initial structure to simulate the internal structure of 3D proximal tibia for old people with 6° valgus deformity. Four regions of interest (ROIs) were selected in the proximal tibia to quantitatively analyze BMD and compare with the clinical measurements. Results The simulation results showed that the BMD distribution in 3D proximal tibia was consistent with clinical measurements in normal knees and that in valgus knees was consistent with the measurement of patients with osteoarthritis in clinics. Conclusions It is shown that the change of mechanical environment is the main cause for the change of subchondral bone structure, and being under abnormal mechanical environment for a long time may lead to osteoarthritis. Besides, the simulation method adopted in this paper can more accurately simulate the internal structure of 3D proximal tibia under different mechanical environments. It helps to better understand the mechanism of osteoarthritis and provides theoretical basis and computational method for the prevention and treatment of osteoarthritis. It can also serve as basis for further study on periprosthetic BMD changes after total knee arthroplasty, and provide a theoretical basis for optimization design of prosthesis. PMID:24359345

Impact of indoor environment on path loss in body area networks.

PubMed

Hausman, Sławomir; Januszkiewicz, Łukasz

2014-10-20

In this paper the influence of an example indoor environment on narrowband radio channel path loss for body area networks operating around 2.4 GHz is investigated using computer simulations and on-site measurements. In contrast to other similar studies, the simulation model included both a numerical human body phantom and its environment-room walls, floor and ceiling. As an example, radio signal attenuation between two different configurations of transceivers with dipole antennas placed in a direct vicinity of a human body (on-body scenario) is analyzed by computer simulations for several types of reflecting environments. In the analyzed case the propagation environments comprised a human body and office room walls. As a reference environment for comparison, free space with only a conducting ground plane, modelling a steel mesh reinforced concrete floor, was chosen. The transmitting and receiving antennas were placed in two on-body configurations chest-back and chest-arm. Path loss vs. frequency simulation results obtained using Finite Difference Time Domain (FDTD) method and a multi-tissue anthropomorphic phantom were compared to results of measurements taken with a vector network analyzer with a human subject located in an average-size empty cuboidal office room. A comparison of path loss values in different environments variants gives some qualitative and quantitative insight into the adequacy of simplified indoor environment model for the indoor body area network channel representation.

Development of a Turbofan Engine Simulation in a Graphical Simulation Environment

NASA Technical Reports Server (NTRS)

Parker, Khary I.; Guo, Ten-Heui

2003-01-01

This paper presents the development of a generic component level model of a turbofan engine simulation with a digital controller, in an advanced graphical simulation environment. The goal of this effort is to develop and demonstrate a flexible simulation platform for future research in propulsion system control and diagnostic technology. A previously validated FORTRAN-based model of a modern, high-performance, military-type turbofan engine is being used to validate the platform development. The implementation process required the development of various innovative procedures, which are discussed in the paper. Open-loop and closed-loop comparisons are made between the two simulations. Future enhancements that are to be made to the modular engine simulation are summarized.

Use of Heuristics to Facilitate Scientific Discovery Learning in a Simulation Learning Environment in a Physics Domain

ERIC Educational Resources Information Center

Veermans, Koen; van Joolingen, Wouter; de Jong, Ton

2006-01-01

This article describes a study into the role of heuristic support in facilitating discovery learning through simulation-based learning. The study compares the use of two such learning environments in the physics domain of collisions. In one learning environment (implicit heuristics) heuristics are only used to provide the learner with guidance…

The Potential of Simulated Environments in Teacher Education: Current and Future Possibilities

ERIC Educational Resources Information Center

Dieker, Lisa A.; Rodriguez, Jacqueline A.; Lignugaris/Kraft, Benjamin; Hynes, Michael C.; Hughes, Charles E.

2014-01-01

The future of virtual environments is evident in many fields but is just emerging in the field of teacher education. In this article, the authors provide a summary of the evolution of simulation in the field of teacher education and three factors that need to be considered as these environments further develop. The authors provide a specific…

AN-CASE NET-CENTRIC modeling and simulation

NASA Astrophysics Data System (ADS)

Baskinger, Patricia J.; Chruscicki, Mary Carol; Turck, Kurt

2009-05-01

The objective of mission training exercises is to immerse the trainees into an environment that enables them to train like they would fight. The integration of modeling and simulation environments that can seamlessly leverage Live systems, and Virtual or Constructive models (LVC) as they are available offers a flexible and cost effective solution to extending the "war-gaming" environment to a realistic mission experience while evolving the development of the net-centric enterprise. From concept to full production, the impact of new capabilities on the infrastructure and concept of operations, can be assessed in the context of the enterprise, while also exposing them to the warfighter. Training is extended to tomorrow's tools, processes, and Tactics, Techniques and Procedures (TTPs). This paper addresses the challenges of a net-centric modeling and simulation environment that is capable of representing a net-centric enterprise. An overview of the Air Force Research Laboratory's (AFRL) Airborne Networking Component Architecture Simulation Environment (AN-CASE) is provide as well as a discussion on how it is being used to assess technologies for the purpose of experimenting with new infrastructure mechanisms that enhance the scalability and reliability of the distributed mission operations environment.

Using the PhysX engine for physics-based virtual surgery with force feedback.

PubMed

Maciel, Anderson; Halic, Tansel; Lu, Zhonghua; Nedel, Luciana P; De, Suvranu

2009-09-01

The development of modern surgical simulators is highly challenging, as they must support complex simulation environments. The demand for higher realism in such simulators has driven researchers to adopt physics-based models, which are computationally very demanding. This poses a major problem, since real-time interactions must permit graphical updates of 30 Hz and a much higher rate of 1 kHz for force feedback (haptics). Recently several physics engines have been developed which offer multi-physics simulation capabilities, including rigid and deformable bodies, cloth and fluids. While such physics engines provide unique opportunities for the development of surgical simulators, their higher latencies, compared to what is necessary for real-time graphics and haptics, offer significant barriers to their use in interactive simulation environments. In this work, we propose solutions to this problem and demonstrate how a multimodal surgical simulation environment may be developed based on NVIDIA's PhysX physics library. Hence, models that are undergoing relatively low-frequency updates in PhysX can exist in an environment that demands much higher frequency updates for haptics. We use a collision handling layer to interface between the physical response provided by PhysX and the haptic rendering device to provide both real-time tissue response and force feedback. Our simulator integrates a bimanual haptic interface for force feedback and per-pixel shaders for graphics realism in real time. To demonstrate the effectiveness of our approach, we present the simulation of the laparoscopic adjustable gastric banding (LAGB) procedure as a case study. To develop complex and realistic surgical trainers with realistic organ geometries and tissue properties demands stable physics-based deformation methods, which are not always compatible with the interaction level required for such trainers. We have shown that combining different modelling strategies for behaviour, collision and graphics is possible and desirable. Such multimodal environments enable suitable rates to simulate the major steps of the LAGB procedure.

Simulation tools for robotics research and assessment

NASA Astrophysics Data System (ADS)

Fields, MaryAnne; Brewer, Ralph; Edge, Harris L.; Pusey, Jason L.; Weller, Ed; Patel, Dilip G.; DiBerardino, Charles A.

2016-05-01

The Robotics Collaborative Technology Alliance (RCTA) program focuses on four overlapping technology areas: Perception, Intelligence, Human-Robot Interaction (HRI), and Dexterous Manipulation and Unique Mobility (DMUM). In addition, the RCTA program has a requirement to assess progress of this research in standalone as well as integrated form. Since the research is evolving and the robotic platforms with unique mobility and dexterous manipulation are in the early development stage and very expensive, an alternate approach is needed for efficient assessment. Simulation of robotic systems, platforms, sensors, and algorithms, is an attractive alternative to expensive field-based testing. Simulation can provide insight during development and debugging unavailable by many other means. This paper explores the maturity of robotic simulation systems for applications to real-world problems in robotic systems research. Open source (such as Gazebo and Moby), commercial (Simulink, Actin, LMS), government (ANVEL/VANE), and the RCTA-developed RIVET simulation environments are examined with respect to their application in the robotic research domains of Perception, Intelligence, HRI, and DMUM. Tradeoffs for applications to representative problems from each domain are presented, along with known deficiencies and disadvantages. In particular, no single robotic simulation environment adequately covers the needs of the robotic researcher in all of the domains. Simulation for DMUM poses unique constraints on the development of physics-based computational models of the robot, the environment and objects within the environment, and the interactions between them. Most current robot simulations focus on quasi-static systems, but dynamic robotic motion places an increased emphasis on the accuracy of the computational models. In order to understand the interaction of dynamic multi-body systems, such as limbed robots, with the environment, it may be necessary to build component-level computational models to provide the necessary simulation fidelity for accuracy. However, the Perception domain remains the most problematic for adequate simulation performance due to the often cartoon nature of computer rendering and the inability to model realistic electromagnetic radiation effects, such as multiple reflections, in real-time.

Multiple-Sensor Discrimination of Closely-Spaced Objects on a Ballistic Trajectory

DTIC Science & Technology

2015-05-18

Nominal System Architecture ..................................................................................... 8 2 Simulation Environment... architecture ........................................................................................... 8 Figure 2. Simulation environment developed...uncertainty band for one or multiple sensors within the observation architecture . Resolving targets from one sensor image to another can prove difficult

Quantum critical probing and simulation of colored quantum noise

NASA Astrophysics Data System (ADS)

Mascarenhas, Eduardo; de Vega, Inés

2017-12-01

We propose a protocol to simulate the evolution of a non-Markovian open quantum system by considering a collisional process with a many-body system, which plays the role of an environment. As a result of our protocol, the environment spatial correlations are mapped into the time correlations of a noise that drives the dynamics of the open system. Considering the weak coupling limit, the open system can also be considered as a probe of the environment properties. In this regard, when preparing the environment in its ground state, a measurement of the dynamics of the open system allows to determine the length of the environment spatial correlations and therefore its critical properties. To illustrate our proposal we simulate the full system dynamics with matrix-product-states and compare this to the reduced dynamics obtained with an approximated variational master equation.

Atomic oxygen effects on spacecraft materials: The state of the art of our knowledge

NASA Technical Reports Server (NTRS)

Koontz, Steven L.

1989-01-01

In the flight materials exposure data base extensive quantitative data is available from limited exposures in a narrow range of orbital environments. More data is needed in a wider range of environments as well as longer exposure times. Synergistic effects with other environmental factors; polar orbit and higher altitude environments; and real time materials degradation data is needed to understand degradation kinetics and mechanism. Almost no laboratory data exists from high fidelity simulations of the LEO environment. Simulation and test system are under development, and the data base is scanty. Theoretical understanding of hyperthermal atom surface reactions in the LEO environment is not good enough to support development of reliable accelerated test methods. The laser sustained discharge, atom beam sources are the most promising high fidelity simulation-test systems at this time.

Simulation of the Effect of Realistic Space Vehicle Environments on Binary Metal Alloys

NASA Technical Reports Server (NTRS)

Westra, Douglas G.; Poirier, D. R.; Heinrich, J. C.; Sung, P. K.; Felicelli, S. D.; Phelps, Lisa (Technical Monitor)

2001-01-01

Simulations that assess the effect of space vehicle acceleration environments on the solidification of Pb-Sb alloys are reported. Space microgravity missions are designed to provide a near zero-g acceleration environment for various types of scientific experiments. Realistically. these space missions cannot provide a perfect environment. Vibrations caused by crew activity, on-board experiments, support systems stems (pumps, fans, etc.), periodic orbital maneuvers, and water dumps can all cause perturbations to the microgravity environment. In addition, the drag on the space vehicle is a source of acceleration. Therefore, it is necessary to predict the impact of these vibration-perturbations and the steady-state drag acceleration on the experiments. These predictions can be used to design mission timelines. so that the experiment is run during times that the impact of the acceleration environment is acceptable for the experiment of interest. The simulations reported herein were conducted using a finite element model that includes mass, species, momentum, and energy conservation. This model predicts the existence of "channels" within the processing mushy zone and subsequently "freckles" within the fully processed solid, which are the effects of thermosolutal convection. It is necessary to mitigate thermosolutal convection during space experiments of metal alloys, in order to study and characterize diffusion-controlled transport phenomena (microsegregation) that are normally coupled with macrosegregation. The model allows simulation of steady-state and transient acceleration values ranging from no acceleration (0 g). to microgravity conditions (10(exp -6) to 10(exp -3) g), to terrestrial gravity conditions (1 g). The transient acceleration environments simulated were from the STS-89 SpaceHAB mission and from the STS-94 SpaceLAB mission. with on-orbit accelerometer data during different mission periods used as inputs for the simulation model. Periods of crew exercise, quiet (no crew activity), and nominal conditions from STS-89 were used as simulation inputs as were periods of nominal. overboard water-dump, and free-drift (no orbit maneuvering operations) from STS-94. Steady-state acceleration environments of 0.0 and 10(exp -6) to 10(exp -1) g were also simulated, to serve as a comparison to the transient data and to assess an acceptable magnitude for the steady-state vehicle drag

On the spatial distribution and evolution of ultrafine aerosols in urban air

NASA Astrophysics Data System (ADS)

Dall'Osto, M.; Querol, X.; Alastuey, A.; O'Dowd, C.; Harrison, R. M.; Wenger, J.; Gómez-Moreno, F. J.

2012-07-01

Sources and evolution of ultrafine particles (<0.1 μ m diameter) were investigated both horizontally and vertically in the large urban agglomerate of Barcelona, Spain. Within the SAPUSS project (Solving Aerosol Problems by Using Synergistic Strategies), a large number of instruments was deployed simultaneously at different monitoring sites (road, two urban background, regional background, urban tower 150 μa.s.l., urban background tower site 80 m a.s.l.) during a 4 week period in September-October 2010. Particle number concentrations (N>5nm) are highly correlated with black carbon (BC) at all sites only under strong vehicular traffic influences. By contrast, under clean atmospheric conditions (low condensation sinks, CS) such correlation diverges towards much higher N/BC ratios at all sites, indicating additional sources of particles including secondary production of freshly nucleated particles. This is also evident in the urban background annual mean diurnal trend of N/BC, showing a midday peak in all seasons. Size-resolved aerosol distributions (N10-500) as well as particle number concentrations (N>5nm) allow us to identify two types of nucleation and growth events: a regional type event originating in the whole study region and impacting almost simultaneously the urban city of Barcelona and the surrounding background area; and an urban type which originates only within the city centre but whose growth continues while transported away from the city to the regional background. Furthermore, during these clean air days, higher N are found at tower level than at ground level only in the city centre whereas such a difference is not so pronounced at the remote urban background tower. In other words, this study suggests that the column of air above the city ground level possesses the best compromise between low CS and high vapour source, hence enhancing the concentrations of freshly nucleated particles. By contrast, within stagnant polluted atmospheric conditions, higher N and BC concentrations are always measured at ground level relative to tower level at all sites. Our study suggests that the city centre is a source of both non-volatile traffic primary (29-39%) and secondary freshly nucleated particles (up to 61-71%) at all sites. We suggest that organic compounds evaporating from freshly emitted traffic particles are a possible candidate for new particle formation within the city and urban plume.

Simultaneous Quantification of Forskolin and Iso-Forskolin in Coleus forskohlii (Wild.) Briq. and Identification of Elite Chemotype, Collected from Eastern Ghats (India)

PubMed Central

Shukla, Pushpendra Kumar; Misra, Ankita; Kumar, Manish; Jaichand; Singh, Kuldeep; Akhtar, Juber; Srivastava, Sharad; Agrawal, Pawan K; Singh Rawat, Ajay K

2017-01-01

Background: Coleus forskohlii is a well-known industrially important medicinal plant, for its high forskolin content. Objective: A simple, selective, and sensitive high-performance thin layer chromatography (HPTLC) method was developed and validated for simultaneous quantification of forskolin and iso-forskolin in C. forskohlii germplasm collected from the Eastern Ghats, India. Materials and Methods: Chromatographic separation of the targeted marker(s) was obtained on precoated silica plates using toluene: ethyl acetate: methanol (90:30:0.5, v/v/v) as the mobile phase. Results: Densitometric quantification of forskolin and iso-forskolin was carried out at 545 nm. Forskolin and iso-forskolin were identified by comparing the ultraviolet spectra of standard and sample track at Rf of 0.64 ± 0.02 and 0.36 ± 0.01, after derivatization with anisaldehyde sulfuric acid reagent. The linearity of both the analytes was obtained in the range of 300–1200 ng/spot with the regression coefficient (R2) of 0.991 and 0.986. Recovery of analyte (s) at three levels, namely, 100, 150, and 200 ng/spot was found to be 100.46% ± 0.29%, 99.64% ± 0.33%, 100.02% ± 0.76% and 99.76% ± 0.62%, 99.56% ± 0.35%, 100.02% ± 0.22%, respectively, for forskolin and iso-forskolin. The content of forskolin and iso-forskolin varies from 0.046% to 0.187% and 0.002% to 0.077%, respectively (dry weight basis), the maximum content of both the markers was found in NBC-31, from Thakurwada, Maharashtra. Conclusion: The developed HPTLC method was linear, accurate, and reliable as per the International Council for Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use guidelines. The study aids in the identification of elite chemotype for commercial prospection of industrially viable medicinal crop. SUMMARY 12 Samples are collected from different locations of the eastern ghat regionsQuantification of two major marker forskolin and iso forskolinThe maximum content of both the markers was found in NBC -31, from Thakurwada, MaharashtraIdentification of elite chemotype of collected samples may be useful for commercial prospection in industries. PMID:29491648

Modeling and Performance Simulation of the Mass Storage Network Environment

NASA Technical Reports Server (NTRS)

Kim, Chan M.; Sang, Janche

2000-01-01

This paper describes the application of modeling and simulation in evaluating and predicting the performance of the mass storage network environment. Network traffic is generated to mimic the realistic pattern of file transfer, electronic mail, and web browsing. The behavior and performance of the mass storage network and a typical client-server Local Area Network (LAN) are investigated by modeling and simulation. Performance characteristics in throughput and delay demonstrate the important role of modeling and simulation in network engineering and capacity planning.

IMPETUS - Interactive MultiPhysics Environment for Unified Simulations.

PubMed

Ha, Vi Q; Lykotrafitis, George

2016-12-08

We introduce IMPETUS - Interactive MultiPhysics Environment for Unified Simulations, an object oriented, easy-to-use, high performance, C++ program for three-dimensional simulations of complex physical systems that can benefit a large variety of research areas, especially in cell mechanics. The program implements cross-communication between locally interacting particles and continuum models residing in the same physical space while a network facilitates long-range particle interactions. Message Passing Interface is used for inter-processor communication for all simulations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Simulating Open Quantum Systems with Hamiltonian Ensembles and the Nonclassicality of the Dynamics

NASA Astrophysics Data System (ADS)

Chen, Hong-Bin; Gneiting, Clemens; Lo, Ping-Yuan; Chen, Yueh-Nan; Nori, Franco

2018-01-01

The incoherent dynamical properties of open quantum systems are generically attributed to an ongoing correlation between the system and its environment. Here, we propose a novel way to assess the nature of these system-environment correlations by examining the system dynamics alone. Our approach is based on the possibility or impossibility to simulate open-system dynamics with Hamiltonian ensembles. As we show, such (im)possibility to simulate is closely linked to the system-environment correlations. We thus define the nonclassicality of open-system dynamics in terms of the nonexistence of a Hamiltonian-ensemble simulation. This classifies any nonunital open-system dynamics as nonclassical. We give examples for open-system dynamics that are unital and classical, as well as unital and nonclassical.

Virtual agents in a simulated virtual training environment

NASA Technical Reports Server (NTRS)

Achorn, Brett; Badler, Norman L.

1993-01-01

A drawback to live-action training simulations is the need to gather a large group of participants in order to train a few individuals. One solution to this difficulty is the use of computer-controlled agents in a virtual training environment. This allows a human participant to be replaced by a virtual, or simulated, agent when only limited responses are needed. Each agent possesses a specified set of behaviors and is capable of limited autonomous action in response to its environment or the direction of a human trainee. The paper describes these agents in the context of a simulated hostage rescue training session, involving two human rescuers assisted by three virtual (computer-controlled) agents and opposed by three other virtual agents.

Thermal-environment testing of a 30-cm engineering model thruster

NASA Technical Reports Server (NTRS)

Mirtich, M. J.

1976-01-01

An experimental test program was carried out to document all 30-cm electron bombardment Hg ion bombardment thruster functions and characteristics over the thermal environment of several proposed missions. An engineering model thruster was placed in a thermal test facility equipped with -196 C walls and solar simulation. The thruster was cold soaked and exposed to simulated eclipses lasting in duration from 17 to 72 minutes. The thruster was operated at quarter, to full beam power in various thermal configurations which simulated multiple thruster operation, and was also exposed to 1 and 2 suns solar simulation. Thruster control characteristics and constraints; performance, including thrust magnitude and direction; and structural integrity were evaluated over the range of thermal environments tested.

Hyperthermal Environments Simulator for Nuclear Rocket Engine Development

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Foote, John P.; Clifton, W. B.; Hickman, Robert R.; Wang, Ten-See; Dobson, Christopher C.

2011-01-01

An arc-heater driven hyperthermal convective environments simulator was recently developed and commissioned for long duration hot hydrogen exposure of nuclear thermal rocket materials. This newly established non-nuclear testing capability uses a high-power, multi-gas, wall-stabilized constricted arc-heater to produce hightemperature pressurized hydrogen flows representative of nuclear reactor core environments, excepting radiation effects, and is intended to serve as a low-cost facility for supporting non-nuclear developmental testing of hightemperature fissile fuels and structural materials. The resulting reactor environments simulator represents a valuable addition to the available inventory of non-nuclear test facilities and is uniquely capable of investigating and characterizing candidate fuel/structural materials, improving associated processing/fabrication techniques, and simulating reactor thermal hydraulics. This paper summarizes facility design and engineering development efforts and reports baseline operational characteristics as determined from a series of performance mapping and long duration capability demonstration tests. Potential follow-on developmental strategies are also suggested in view of the technical and policy challenges ahead. Keywords: Nuclear Rocket Engine, Reactor Environments, Non-Nuclear Testing, Fissile Fuel Development.

Virtual reality sickness questionnaire (VRSQ): Motion sickness measurement index in a virtual reality environment.

PubMed

Kim, Hyun K; Park, Jaehyun; Choi, Yeongcheol; Choe, Mungyeong

2018-05-01

This study aims to develop a motion sickness measurement index in a virtual reality (VR) environment. The VR market is in an early stage of market formation and technological development, and thus, research on the side effects of VR devices such as simulator motion sickness is lacking. In this study, we used the simulator sickness questionnaire (SSQ), which has been traditionally used for simulator motion sickness measurement. To measure the motion sickness in a VR environment, 24 users performed target selection tasks using a VR device. The SSQ was administered immediately after each task, and the order of work was determined using the Latin square design. The existing SSQ was revised to develop a VR sickness questionnaire, which is used as the measurement index in a VR environment. In addition, the target selection method and button size were found to be significant factors that affect motion sickness in a VR environment. The results of this study are expected to be used for measuring and designing simulator sickness using VR devices in future studies. Copyright © 2018 Elsevier Ltd. All rights reserved.

Comparison of High-Performance Fiber Materials Properties in Simulated and Actual Space Environments

NASA Technical Reports Server (NTRS)

Finckernor, M. M.

2017-01-01

A variety of high-performance fibers, including Kevlar, Nomex, Vectran, and Spectra, have been tested for durability in the space environment, mostly the low Earth orbital environment. These materials have been tested in yarn, tether/cable, and fabric forms. Some material samples were tested in a simulated space environment, such as the Atomic Oxygen Beam Facility and solar simulators in the laboratory. Other samples were flown on the International Space Station as part of the Materials on International Space Station Experiment. Mass loss due to atomic oxygen erosion and optical property changes due to ultraviolet radiation degradation are given. Tensile test results are also presented, including where moisture loss in a vacuum had an impact on tensile strength.

Galaxy properties and the cosmic web in simulations

NASA Astrophysics Data System (ADS)

Metuki, Ofer; Libeskind, Noam I.; Hoffman, Yehuda; Crain, Robert A.; Theuns, Tom

2015-01-01

We seek to understand the relationship between galaxy properties and their local environment, which calls for a proper formulation of the notion of environment. We analyse the Galaxies-Intergalactic Medium Interaction Calculation suite of cosmological hydrodynamical simulations within the framework of the cosmic web as formulated by Hoffman et al., focusing on properties of simulated dark matter haloes and luminous galaxies with respect to voids, sheets, filaments, and knots - the four elements of the cosmic web. We find that the mass functions of haloes depend on environment, which drives other environmental dependence of galaxy formation. The web shapes the halo mass function, and through the strong dependence of the galaxy properties on the mass of their host haloes, it also shapes the galaxy-(web) environment dependence.

Virtual acoustic environments for comprehensive evaluation of model-based hearing devices.

PubMed

Grimm, Giso; Luberadzka, Joanna; Hohmann, Volker

2018-06-01

Create virtual acoustic environments (VAEs) with interactive dynamic rendering for applications in audiology. A toolbox for creation and rendering of dynamic virtual acoustic environments (TASCAR) that allows direct user interaction was developed for application in hearing aid research and audiology. The software architecture and the simulation methods used to produce VAEs are outlined. Example environments are described and analysed. With the proposed software, a tool for simulation of VAEs is available. A set of VAEs rendered with the proposed software was described.

MADNESS: A Multiresolution, Adaptive Numerical Environment for Scientific Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrison, Robert J.; Beylkin, Gregory; Bischoff, Florian A.

2016-01-01

MADNESS (multiresolution adaptive numerical environment for scientific simulation) is a high-level software environment for solving integral and differential equations in many dimensions that uses adaptive and fast harmonic analysis methods with guaranteed precision based on multiresolution analysis and separated representations. Underpinning the numerical capabilities is a powerful petascale parallel programming environment that aims to increase both programmer productivity and code scalability. This paper describes the features and capabilities of MADNESS and briefly discusses some current applications in chemistry and several areas of physics.

MHD Simulation of the Interplanetary Environment in the Ecliptic Plane during the 3-9 February 1986 Solar and Geomagnetic Activity.

DTIC Science & Technology

1986-09-01

AD-R173 822 MWD SIMULATION OF THE INTERPLANETARY ENVIRONMENT IN THE 1/1 ECLIPTIC PLRNE DU (U) AIR FORCE GEOPHYSICS LAS HANSCOM AFB MA M DRYER ET AL...RESOLUTION TEST CHART M4rtqOAI RIM) Of STANDARMS 96I-A AFGL-TR-86-0189 M Simulation of the Interplanetary Environment in the Ecliptic Plane During the 3-9...CLASSIFICATION OF THIS PAGE Cant of Block 11: in the Ecliptic Plane During the 3-9 February 1986 Solar and Geomagnetic Activity Cant of Block 19 (ABSTRACT

Robot, computer problem solving system

NASA Technical Reports Server (NTRS)

Becker, J. D.

1972-01-01

The development of a computer problem solving system is reported that considers physical problems faced by an artificial robot moving around in a complex environment. Fundamental interaction constraints with a real environment are simulated for the robot by visual scan and creation of an internal environmental model. The programming system used in constructing the problem solving system for the simulated robot and its simulated world environment is outlined together with the task that the system is capable of performing. A very general framework for understanding the relationship between an observed behavior and an adequate description of that behavior is included.

Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging.

PubMed

Liu, Peng-Cheng; Liu, Kuan; Liu, Jun-Feng; Xia, Kuo; Chen, Li-Yang; Wu, Xing

2016-09-27

The effect of overexpressing the Indian hedgehog (IHH) gene on the chondrogenic differentiation of rabbit bone marrow-derived mesenchymal stem cells (BMSCs) was investigated in a simulated microgravity environment. An adenovirus plasmid encoding the rabbit IHH gene was constructed in vitro and transfected into rabbit BMSCs. Two large groups were used: conventional cell culture and induction model group and simulated microgravity environment group. Each large group was further divided into blank control group, GFP transfection group, and IHH transfection group. During differentiation induction, the expression levels of cartilage-related and cartilage hypertrophy-related genes and proteins in each group were determined. In the conventional model, the IHH transfection group expressed high levels of cartilage-related factors (Coll2 and ANCN) at the early stage of differentiation induction and expressed high levels of cartilage hypertrophy-related factors (Coll10, annexin 5, and ALP) at the late stage. Under the simulated microgravity environment, the IHH transfection group expressed high levels of cartilage-related factors and low levels of cartilage hypertrophy-related factors at all stages of differentiation induction. Under the simulated microgravity environment, transfection of the IHH gene into BMSCs effectively promoted the generation of cartilage and inhibited cartilage aging and osteogenesis. Therefore, this technique is suitable for cartilage tissue engineering.

The Effects of Exercising in Different Natural Environments on Psycho-Physiological Outcomes in Post-Menopausal Women: A Simulation Study.

PubMed

White, Mathew P; Pahl, Sabine; Ashbullby, Katherine J; Burton, Francesca; Depledge, Michael H

2015-09-23

The current study examined potential psycho-physiological benefits from exercising in simulated natural environments among a sample of post-menopausal women using a laboratory based protocol. Participants cycled on a stationary exercise bike for 15 min while facing either a blank wall (Control) or while watching one of three videos: Urban (Grey), Countryside (Green), Coast (Blue). Blood pressure, heart rate and affective responses were measured pre-post. Heart rate, affect, perceived exertion and time perception were also measured at 5, 10 and 15 min during exercise. Experience evaluation was measured at the end. Replicating most earlier findings, affective, but not physiological, outcomes were more positive for exercise in the simulated Green and, for the first time, Blue environment, compared to Control. Moreover, only the simulated Blue environment was associated with shorter perceived exercise duration than Control and participants were most willing to repeat exercise in the Blue setting. The current research extended earlier work by exploring the effects of "blue exercise" and by using a demographic with relatively low average levels of physical activity. That this sample of postmenopausal women were most willing to repeat a bout of exercise in a simulated Blue environment may be important for physical activity promotion in this cohort.

WriteSim TCExam - An open source text simulation environment for training novice researchers in scientific writing

PubMed Central

2010-01-01

Background The ability to write clearly and effectively is of central importance to the scientific enterprise. Encouraged by the success of simulation environments in other biomedical sciences, we developed WriteSim TCExam, an open-source, Web-based, textual simulation environment for teaching effective writing techniques to novice researchers. We shortlisted and modified an existing open source application - TCExam to serve as a textual simulation environment. After testing usability internally in our team, we conducted formal field usability studies with novice researchers. These were followed by formal surveys with researchers fitting the role of administrators and users (novice researchers) Results The development process was guided by feedback from usability tests within our research team. Online surveys and formal studies, involving members of the Research on Research group and selected novice researchers, show that the application is user-friendly. Additionally it has been used to train 25 novice researchers in scientific writing to date and has generated encouraging results. Conclusion WriteSim TCExam is the first Web-based, open-source textual simulation environment designed to complement traditional scientific writing instruction. While initial reviews by students and educators have been positive, a formal study is needed to measure its benefits in comparison to standard instructional methods. PMID:20509946

Fatigue properties on the failure mode of a dental implant in a simulated body environment

NASA Astrophysics Data System (ADS)

Kim, Min Gun

2011-10-01

This study undertook a fatigue test in a simulated body environment that has reflected the conditions (such as the body fluid conditions, the micro-current of cell membranes, and the chewing force) within a living body. First, the study sought to evaluate the fatigue limit under normal conditions and in a simulated body environment, looking into the governing factors of implant fatigue strength through an observation of the fracture mode. In addition, the crack initiation behavior of a tungsten-carbide-coated abutment screw was examined. The fatigue limit of an implant within the simulated body environment decreased by 19 % compared to the limit noted under normal conditions. Several corrosion pits were observed on the abutment screw after the fatigue test in the simulated body environment. For the model used in this study, the implant fracture was mostly governed by the fatigue failure of the abutment screw; accordingly, the influence by the fixture on the fatigue strength of the implant was noted to be low. For the abutment screw coated with tungsten carbide, several times the normal amount of stress was found to be concentrated on the contact part due to the elastic interaction between the coating material and the base material.